hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06331468 id: MCC-23-GYN-10 briefTitle: Hypofractionated Radiochemotherapy overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-08-01 date: 2028-08-01 date: 2024-03-26 date: 2024-03-26 name: Denise Fabian class: OTHER briefSummary: The goal of this clinical trial is to investigate the use of hypofractionated radiation (delivery of fewer but larger doses of radiation) with concurrent chemotherapy for women with metastatic of bulky uterine cervix cancer. The main questions it aims to answer are:
Following the 3-months post-treatment completion, study participants will be followed for disease progression and survival status until Year 2 post-treatment initiation. NOTE: Cervical cancer patients are routinely followed (clinical surveillance) every 3-months during the first two years post-treatment. conditions: Uterine Cervix Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Cisplatin name: intensity modulated radiation therapy (IMRT) name: high-dose-rate (HDR) brachytherapy measure: MRI assessed rate of complete response measure: MRI assessed rate of complete response measure: progression-free survival (PFS) measure: overall survival (OS) measure: Treatment Completion measure: Treatment Tolerability measure: Change in levels of uterine cervix cancer circulating tumor cells sex: FEMALE minimumAge: 18 Years maximumAge: 120 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Markey Cancer Center city: Lexington state: Kentucky zip: 40506 country: United States lat: 37.98869 lon: -84.47772 hasResults: False
nctId: NCT06331455 id: 23-5501 briefTitle: Treatment of Pulmonary SUlcus, Pancoast and Chest Wall Non-small Cell Lung Cancer Employing Radiation, Immuno-oncology and Resection acronym: SUPER overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-12 date: 2026-04 date: 2024-03-26 date: 2024-03-26 name: Marc de Perrot class: OTHER name: Ozmosis Research Inc. briefSummary: The SUPER trial is a prospective Phase II trial. It is designed for patients with stage 2 or 3 non-small cell lung cancer (NSCLC) prior to surgery.
Patients who are enrolled in this trial will receive combination of Non-ablative oligofractionated radiation (NORT) and two cycles of Durvalumab, an immunotherapy drug before their surgery. conditions: Lung Cancer Patients conditions: Non-small Cell Lung Cancer (NSCLC) studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This is a multi-centre, phase 2 trial in patients with T2b-3N0-1M0 NSCLC evaluating the biologic efficacy of NORT-Durvalumab administered prior to surgery. primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: Durvalumab name: Non-ablative oligofractionated radiation (NORT) measure: To Measure CD8 TILs density & Major Pathological Response (MPR) measure: To explore the efficacy and safety of NORT-durvalumab sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06331442 id: 006503905 briefTitle: The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-11 date: 2024-11 date: 2024-03-26 date: 2024-03-26 name: University of Zagreb class: OTHER briefSummary: This randomized controlled trial will be conducted on 40 orthodontic patients at the Department of Orthodontics, University Hospital Centre Zagreb, Croatia. Respondents will be randomly allocated into 4 groups (n=10). The first group will receive photodynamic therapy, the second tricalcium phosphate varnish with 5% NaF (sodium fluoride), the third 1% chlorhexidine varnish, while the fourth group will be the negative control. Before and after the mentioned interventions, the participants will have the amount of plaque measured using the plaque index and the bacteriological composition of the plaque assessed using the mass spectrometry and PCR. The gingival condition will be assessed using the gingival index. Also, the occurrence of white spot lesions will be evaluated on intraoral photographs. conditions: Plaque, Dental conditions: Dental Plaque Induced Gingivitis conditions: White Spot Lesion studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Photodynamic therapy name: Tricalcium phosphate (TCP) varnish with 5% NaF name: Chlorhexidine varnish measure: Assessment of dental plaque accumulation using plaque index measure: Assessment of the bacteriological composition of supragingival plaque using mass spectrometry measure: Assessment of the bacteriological composition of subgingival plaque using polymerase chain reaction measure: Assessment of gingival condition using gingival index measure: Diagnosis of white spot lesions on intraoral photographs sex: ALL minimumAge: 12 Years maximumAge: 17 Years stdAges: CHILD hasResults: False
nctId: NCT06331429 id: EmoTiCare briefTitle: Emoticare: Serious Game for the Adaptation to the Disease of Adolescents With Type 1 Diabetes Mellitus. overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2024-09 date: 2025-02 date: 2024-03-26 date: 2024-03-28 name: University of Valencia class: OTHER name: Universitat Politècnica de València briefSummary: The intervention program targets adolescents with chronic Type 1 Diabetes Mellitus. Given the critical developmental stage and life transitions, necessitating robust personal resources, psychological support becomes imperative. To foster socioemotional skills and overall well-being, particularly crucial for averting future emotional issues and promoting a healthier, more fulfilling life, this support is especially vital for those dealing with chronic illnesses. Such conditions pose a risk for psychological problems, potentially complicating treatment and prognosis. Presently, digital and technological platforms are integrating psychological interventions for patients with chronic diseases, showcasing an innovative approach to address psychological challenges.
The platform integrates new technologies for assessment and intervention. Ecological Momentary Assessment enables real-time evaluation, with data transferred to the technological platform. Artificial intelligence personalizes interventions based on participants' socio-demographic characteristics and assessment results. Ecological Momentary Intervention is employed for in-context treatments in participants' daily lives and natural environments. A serious game method, proven effective in various interventions, is used to engage adolescents and young people intrinsically. The game encompasses six main areas aligning with theoretical models, facilitating the development of socio-emotional competencies, and promoting physical and psychological health. It addresses different aspects of psychological and subjective well-being, reinforcing resources needed to navigate vital changes in these developmental stages, especially when living with a chronic illness. conditions: Type 1 Diabetes conditions: Adolescent Development studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 200 type: ESTIMATED name: EmoTiCare measure: Change Quality of Life (Baseline-Pre-Post) measure: Change Emotional and Behavioral Problems (Baseline-Pre-Post) measure: Change Emotional Competences (Baseline-Pre-Post) measure: Change Self-concept (Baseline-Pre-Post) measure: Change Coping (Baseline-Pre-Post) measure: Change Social Skills (Baseline-Pre-Post) measure: Change Threat of disease(Baseline-Pre-Post) measure: Change Psychoeducation Diabetes measure: Change Resilience (Baseline-Pre-Post) measure: Glycaemic control (Baseline-Pre-Post) sex: ALL minimumAge: 12 Years maximumAge: 16 Years stdAges: CHILD facility: Universitat de València city: Valencia country: Spain name: Marián Pérez-Marín, PhD role: CONTACT phone: 963983392 email: marian.perez@uv.es name: Selene Valero Moreno, PhD role: SUB_INVESTIGATOR name: Inmaculada Montoya-Castilla, PhD role: SUB_INVESTIGATOR name: Javier Martín Ávila, MsC role: SUB_INVESTIGATOR name: Esther Rodríguez-Jiménez, MsC role: SUB_INVESTIGATOR lat: 39.46975 lon: -0.37739 hasResults: False
nctId: NCT06331416 id: 208_2022H briefTitle: One-device Multiparametric Home Telemonitoring of Patients With Chronic Obstructive Pulmonary Disease Exacerbation overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-09-30 date: 2024-03-26 date: 2024-03-26 name: University of Trieste class: OTHER briefSummary: Chronic obstructive pulmonary disease (COPD) exacerbations are risk factors for disease progression and short-term re- hospitalizations. We propose a randomized controlled trial to evaluate the efficacy of a one-device multiparameter telemonitoring in reducing functional decline, symptoms, and risk of re-hospitalization of patients discharged after hospitalization for exacerbated COPD. conditions: COPD conditions: COPD Exacerbation Acute studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Open-label randomized controlled trial, allocation ratio 1:1 primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 60 type: ESTIMATED name: Telemonitoring measure: Re-hospitalization at 90 days measure: Re-hospitalization at 30 days measure: Functional decline measure: Unplanned medical evaluations measure: Need for mechanical ventilation at 30 days measure: Need for mechanical ventilation at 90 days measure: Satisfaction score sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06331403 id: 24-009 briefTitle: Open Pilot Trial of a Mind-Body Sexual Well-Being Intervention for Female GI Cancer Survivors overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-03-26 date: 2024-03-26 name: Massachusetts General Hospital class: OTHER name: Harvard Medical School (HMS and HSDM) briefSummary: The primary goal of this protocol is to conduct an open pilot to collect initial quantitative and qualitative feedback on the intervention that the investigators are developing. To do so, the investigators will deliver a newly-developed intervention to up to 2 consecutive groups of female colorectal and anal cancer survivors (n = up to 10 per group, total N = up to 20). Participants will provide feedback regarding intervention acceptability, feasibility, and perceived benefit.
As a secondary aim, the investigators will explore the preliminary effects of the intervention on psychosocial measures of satisfaction with sexuality and impact of functional limitations, coping abilities, acceptance of body image changes, loneliness, and anticipated stigma. As noted above, the investigators will not set specific criteria to establish preliminary efficacy, nor will they consider statistical significance as an indicator of the study's efficacy for these outcomes. Instead, the investigators will consider pre-post intervention effect sizes to consider the need for refinement of study procedures/measurement in a future larger trial.
In future, larger-scale, work, the investigators intend to conduct a larger randomized pilot trial to assess intervention acceptability, feasibility, as well as preliminary efficacy on essential outcomes related to sexual well-being. conditions: Colorectal Cancer conditions: Anal Cancer conditions: Sexual Dysfunction studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 20 type: ESTIMATED name: Mind-Body Group Intervention measure: Feasibility of Intervention measure: Acceptability of Intervention sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06331390 id: 2181-198-03-04-24-0008 briefTitle: Assessment of Niacinamide Cosmetic Product Efficacy in Model of Irritant Contact Dermatitis overallStatus: RECRUITING date: 2024-04 date: 2024-06 date: 2024-07 date: 2024-03-26 date: 2024-03-26 name: University of Split, School of Medicine class: OTHER briefSummary: Testing the effectiveness and safety of cosmetics with niacinamide in irritant contact dermatitis: A Randomised, Controlled Trial will be conducted at USSM. Healthy volunteers will be included (at least 25) and test sites are forearms. Sodium lauryl sulphate will be used to induce contact dermatitis and participants will be measured for 7 days conditions: Contact Dermatitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 25 type: ESTIMATED name: niacinamide cosmetic product name: placebo measure: tewameter sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: University of Split School of Medicine status: RECRUITING city: Split country: Croatia name: Josipa Bukic role: CONTACT phone: 00385917933752 email: jbukic@mefst.hr lat: 43.50891 lon: 16.43915 hasResults: False
nctId: NCT06331377 id: 17-004541 id: NCI-2024-01765 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: 17-004541 type: OTHER domain: Mayo Clinic Institutional Review Board briefTitle: Clinical and Molecular Characteristics of Histiocytic Disorders overallStatus: RECRUITING date: 2017-07-27 date: 2027-07-31 date: 2027-07-31 date: 2024-03-26 date: 2024-03-26 name: Mayo Clinic class: OTHER briefSummary: This study is being done to collect medical and personal histories as well as a samples of blood, other body fluid and/or tumor/disease tissue for current and future research studies on histiocytic disorders. conditions: Histiocytic Disorder studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: OTHER count: 500 type: ESTIMATED name: Non-Interventional Study measure: Identify molecular markers measure: Change in PD-L1 and T-cell Bim expression sex: ALL minimumAge: 1 Year stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Mayo Clinic in Rochester status: RECRUITING city: Rochester state: Minnesota zip: 55905 country: United States name: Clinical Trials Referral Office role: CONTACT phone: 855-776-0015 email: mayocliniccancerstudies@mayo.edu name: Ronald S. Go, M.D. role: PRINCIPAL_INVESTIGATOR lat: 44.02163 lon: -92.4699 hasResults: False
nctId: NCT06331364 id: Pro00114347 id: R01AI168420 type: NIH link: https://reporter.nih.gov/quickSearch/R01AI168420 briefTitle: TREATment of Lower Respiratory Tract Infection in Sri Lanka (TREAT-SL) acronym: TREAT-SL overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2026-04 date: 2024-03-26 date: 2024-03-26 name: Duke University class: OTHER name: National Institute of Allergy and Infectious Diseases (NIAID) briefSummary: This is a stepped-wedge, cluster-randomized, two-arm, open-label, clinical trial of an electronic clinical decision support tool (eCDST) for the diagnosis and treatment of lower respiratory tract infection (LRTI) among patients at three sites in Southern Province, Sri Lanka.
The study will enroll 765 patients ≥ 14 years of age. Medical wards will be randomized in clusters to the intervention at intervals of 3-6 months until all clusters cross over. Participants will be followed for 30 days from enrollment to record clinical outcomes and any antimicrobials prescribed. conditions: Lower Resp Tract Infection studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: stepped-wedge, cluster randomized, two-arm, open label
This design combines elements of a cluster randomized trial (intervention is applied in clusters) and a before-after design (each cluster switches to intervention). All 9 pairs of wards (clusters) will start with an initial period of usual care. At intervals of 3-6 months (steps), a set of 3 pairs of wards (clusters) will switch in a randomized order to use the intervention, until all pairs of wards have crossed over. primaryPurpose: TREATMENT masking: NONE count: 765 type: ESTIMATED name: electronic clinical decision support tool (eCDST) diagnostic plan measure: Total duration of antibacterial prescription for the index visit measure: Composite of adverse outcomes that could be attributed to withholding antibacterials measure: Proportion of participants using non-invasive ventilation measure: Proportion of participants using mechanical ventilation measure: Proportion of participants readmitted to the hospital measure: Proportion of deaths measure: Proportion of participants seeking subsequent outpatient care for the LRTI illness and receiving an antibacterial prescription measure: Proportion of participants admitted to the intensive care unit (ICU) during index hospitalization measure: Duration of admission to the intensive care unit (ICU) during index hospitalization measure: Number of participants requiring use of supplemental oxygen by nasal cannula or face mask during index hospitalization measure: Duration of supplemental oxygen by nasal cannula or face mask during index hospitalization measure: Duration of non-invasive ventilation during index hospitalization measure: Duration of mechanical ventilation during index hospitalization measure: Duration of index hospitalization measure: Proportion prescribed antibacterials- cumulative measure: Proportion prescribed antibacterials- at time of assessment measure: Total antibacterial exposure per patient during hospitalization measure: Proportion prescribed oseltamivir- cumulative measure: Proportion prescribed oseltamivir- at time of assessment measure: Total oseltamivir exposure per patient during hospitalization measure: Proportion prescribed SARS-CoV-2 antivirals during hospitalization- cumulative measure: Proportion prescribed SARS-CoV-2 antivirals during hospitalization- at time of assessment measure: Physician adherence, as measured by proportion in whom the first recommended diagnostic test (if recommended) was performed measure: Physician adherence, as measured by the proportion in whom the second recommended diagnostic test (if recommended) was performed measure: Physician adherence, as measured by proportion in whom the antibacterial treatment recommendation was followed measure: Physician adherence, as measured by the proportion in whom the oseltamivir treatment recommendation was followed measure: Physician adherence, as measured by the proportion in whom all treatment recommendations were followed sex: ALL minimumAge: 14 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06331351 id: A11203001 briefTitle: Effect of Jing Si Herbal Tea Liquid Packets on Chronic Pharyngolaryngitis overallStatus: RECRUITING date: 2024-02-22 date: 2025-10-31 date: 2025-12-31 date: 2024-03-26 date: 2024-03-26 name: Dalin Tzu Chi General Hospital class: OTHER briefSummary: Chronic pharyngolaryngitis is common and often make people suffer in many aspects. The etiology is numerous, for example, airway hypersensitivity, gastroesophageal acid regurgitation, sicca syndrome, anxiety, etc.
A questionnaire for health and habits was performed at the start of the study, and a questionnaire for Reflux Symptom Index (RSI) was performed at the start and the end of the study. Finally, Student's t-test was used to test the difference between the Jing Si herbal tea group and the control group. And, multivariate linear regression was used to test the violation of clinical factors on the treatment outcome of Jing Si herbal tea liquid packets on chronic pharyngolaryngitis. conditions: Chronic Pharyngitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 120 type: ESTIMATED name: control group name: Jing Si herbal tea liquid packets measure: Health questionnaire measure: Reflux Symptom Index (RSI) sex: ALL minimumAge: 20 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation status: RECRUITING city: Chiayi City zip: 66247 country: Taiwan name: Juen-Haur Hwang, MD, PhD role: CONTACT phone: +886-5-2648000 phoneExt: 5239 email: g120796@tzuchi.com.tw lat: 23.47917 lon: 120.44889 hasResults: False
nctId: NCT06331338 id: 202310085RIND briefTitle: Effects of Using Decision Cycle for Person-Centered Glycemic Management in Type 2 Diabetes overallStatus: RECRUITING date: 2024-02-14 date: 2024-10-31 date: 2025-12-31 date: 2024-03-26 date: 2024-04-01 name: National Taiwan University Hospital class: OTHER briefSummary: Decision cycle for person-centered glycemic management is a new diabetes decision making .It is defined as a purposefully designed holistic care intervention .The goal is to improve the self-care behavior of patients with type 2 diabetes, thereby improving glycated hemoglobin levels and delaying the occurrence of complications. conditions: Type 2 Diabetes studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE whoMasked: PARTICIPANT count: 130 type: ESTIMATED name: Decision Cycle for Person-Centered Glycemic Management name: Traditional diabetes self-management education measure: glycemic control (HbA1c) measure: Diabetes Self-Care Behavior Scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Taiwan University Hospital status: RECRUITING city: Hsinchu zip: 302 country: Taiwan name: Chia-Hui Tsai role: CONTACT phone: 886926124093 email: mtsai0322@gmail.com lat: 24.80361 lon: 120.96861 hasResults: False
nctId: NCT06331325 id: 724 briefTitle: Comparison of Frenotomy and Frenectomy Techniques for Management of High Frenum Attachment in Adults overallStatus: RECRUITING date: 2024-03-20 date: 2024-09-30 date: 2024-09-30 date: 2024-03-26 date: 2024-03-26 name: October University for Modern Sciences and Arts class: OTHER briefSummary: The goal of this randomized clinical trial is to compare frenotomy to frenectomy surgical techniques in the management of high frenum attachment in adults. The main questions it aims to answer are:
* Does Frenotomy procedure result in fewer postoperative complications? Participants will be divided into two groups. The intervention group will involve frenotomy procedure for participants and will be compared to the traditional frenectomy procedure in the comparator group. The level of the frenum will be measured at baseline and after 6 months. Pain scores will be recorded by the participants during the first week. conditions: High Frenum Attachment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized clinical trial. Allocation Ratio: 1:1 primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Participants and outcome assessors will be unaware of the recruitment group. The allocation sequence will be contained within sequentially numbered, opaque, sealed packets that the patients will pull. According to the randomization table, the written number on the paper will allocate the patient to the intervention or control group. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 46 type: ESTIMATED name: Frenotomy name: Frenectomy measure: Rebound / Relapse. measure: Postoperative pain sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: MSA University status: RECRUITING city: Giza zip: 12566 country: Egypt name: Nada Zazou role: CONTACT phone: +201224016945 email: drzazou@hotmail.com lat: 30.00808 lon: 31.21093 hasResults: False