nctId: NCT06330662 id: 05-PA-30-19-6/2023. briefTitle: Effectiveness of Hyaluronic Acid on Multiple Adjacent Gingival Recessions Using a Coronally Advanced Flap overallStatus: ENROLLING_BY_INVITATION date: 2023-09-01 date: 2024-09-01 date: 2025-06-01 date: 2024-03-26 date: 2024-03-26 name: Andelina Sekelja class: OTHER briefSummary: The goal of this clinical randomized trial is to examine the effectiveness of hyaluronic acid in treatment of multiple adjacent gingival recessions in 2 groups. Control group will be presented by using a coronally advanced flap only (CAF) and experimental group will be presented with addition of hyaluronic acid to a coronally advanced flap (CAF+HA). The main question it aims to answer is: is there any difference in the reduction of multiple gingival recessions between the control (CAF) and the test group (CAF + HA)? The research would be conducted on subjects referred for specialist treatment at the Department of Periodontology (Faculty of dental medicine, University of Zagreb). A record would be kept of all patients who underwent a detailed clinical examination, those who did not meet the criteria for inclusion in the study and those who refused to participate in it. Participants who meet the inclusion criteria will undergo a detailed clinical examination and if they agree to participate in the research, they will sign the informed form. During the pre-treatment, patients will receive instructions and a demonstration on proper maintenance of oral hygiene as well as a teeth cleaning. In addition to the informed form, they will fill out the OHIP-14 questionnaire, and the researcher will measure the periodontal indices at the very beginning before the operation, as well as the Schiff index. Patients will be photographed at the baseline as well as at follow-up examinations. The total number of subjects would be 42, or 21 patients in the 2 observed groups. The control group refers to surgical intervention using a coronally advanced flap to cover multiple gingival recessions without the addition of hyaluronic acid (CAF) and the experimental group indicates the surgical intervention using a coronally advanced flap to cover multiple adjacent gingival recessions with the addition of hyaluronic acid intraoperatively (CAF + HA). conditions: Gingival Recession studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The control group refers to surgical intervention using a coronally advanced flap to cover multiple gingival recessions without the addition of hyaluronic acid (CAF) and the experimental group indicates the surgical intervention using a coronally advanced flap to cover multiple adjacent gingival recessions with the addition of hyaluronic acid intraoperatively (CAF + HA). primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: Randomization would first be generated using a computer-selected program, and then the protocol itself would be placed in opaque sealed envelopes and handed to the operator immediately before the procedure with a decision as to whether or not hyaluronic acid (HA) would be applied. In treated areas where HA will not be applied, the operative site will be treated only with saline. The patient as well as the researcher and the outcomes assesssor will not be informed which patient belongs to which group. Randomization and allocation of envelopes as well as allocation of patients to groups will be determined by a fourth party. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 42 type: ESTIMATED name: Testing the effectiveness of hyaluronic acid in experimental group using a coronally advanced flap compared to a control group using a coronally advanced flap only measure: The effect of hyaluronic acid on recession reduction measure: To examine the effect of tissue thickness on recession coverage (KTt) measure: To examine keratinized gingiva width (KTw) measure: To examine changes in periodontal clinical parameters: PPD measure: To examine changes in periodontal clinical parameters: CAL measure: To examine changes in periodontal clinical parameters: REC measure: To examine changes in periodontal clinical parameters: FMPS (full mouth plaque score) measure: To examine changes in periodontal clinical parameters: FMBS (full mouth bleeding score) measure: Assess the healing quality of the operated area by using a RES scale measure: Schiff test tooth examination measure: To examine the impact of oral health on quality of life measure: To evaluate the level of pain postoperatively during the healing of the surgical wound sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Zagreb - School of dental medicine city: Zagreb state: Hrvatska zip: 10 000 country: Croatia lat: 45.81444 lon: 15.97798 hasResults: False