Patients will be followed during 6 months. conditions: Total Hip Arthroplasty studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Multicenter, double-blind, randomized controlled trial in 3 parallel groups (placebo group, nefopam bolus group and nefopam Continuous Intra-Venous Infusion CIVI group). primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: Patient, investigator and outcome assessor will be blind., A nurse anesthetist who will not be involved in the follow up of the patient will receive the kit and prepare the syringes. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 546 type: ESTIMATED name: Nefopam name: Nefopam name: NaCl 0.9% measure: Cumulative morphine consumption from the end of surgery (Day 0 - Hour 0) to the first 24 hours after surgery, expressed in mg of intravenous morphine (including titration in the Post-Anesthesia care Unit PACU). measure: Maximum self-assessed pain using the Numeric Rating Scale ranging from 0 (no pain) to 10 (maximum pain) at rest in the PACU, at rest and on walking between PACU discharge and Hour 24, at Hour 24, and at hospital discharge. measure: Time to return to walking. measure: Time to leave room. measure: Time to climb stairs. measure: Length of stay. measure: Time to abandon canes/crutches. measure: Opioid analgesic consumption between days 1 and 5 or at hospital discharge measure: Chronic pain at 6 months (at rest and walking) using a standardized phone questionnaire. measure: Neuropathic pain score (DN2)The DN2 is a simplified version of the DN4, with 7 items: burning, painful cold, electric shocks, tingling, pins and needles, numbness, itching (scored 0=absent, 1=present). measure: Incidence of all serious AEs during patient follow-up and non-serious AEs. measure: Incidence of patients with morphine side effects measure: Financial impact of spreading the recommended strategy following the results of the clinical study, estimated per year and over a 5-year period, from the point of view of the French Health Insurance and from the hospital perspective. sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Anaesthesia - Intensive care city: Angers zip: 49933 country: France name: Emmanuel RINEAU, MD role: CONTACT phone: 02 41 35 39 51 phoneExt: +33 email: Emmanuel.Rineau@chu-angers.fr name: Emmanuel RINEAU, MD role: PRINCIPAL_INVESTIGATOR lat: 47.46667 lon: -0.55 facility: Anaesthesia - Intensive care city: Blois zip: 41016 country: France name: Raphaël DARMON, MD role: CONTACT phone: 02 54 55 66 33 phoneExt: +33 email: darmonr@ch-blois.fr name: Raphaël DARMON, MD role: PRINCIPAL_INVESTIGATOR lat: 47.58333 lon: 1.33333 facility: Anaesthesia - Intensive care city: Chartres zip: 28018 country: France name: Elias CHADDOUK, MD role: CONTACT phone: 02 37 30 30 30 phoneExt: +33 email: echaddouk@ch-chartres.fr name: Elias CHADDOUK, MD role: PRINCIPAL_INVESTIGATOR lat: 48.44685 lon: 1.48925 facility: Anaesthesia - Intensive care city: Nantes zip: 44000 country: France name: Raphaël CINOTTI, MD role: CONTACT phone: 02 53 48 22 30 phoneExt: +33 email: Raphael.CINOTTI@chu-nantes.fr name: Raphaël CINOTTI, MD role: PRINCIPAL_INVESTIGATOR lat: 47.21725 lon: -1.55336 facility: Anaesthesia - Intensive care city: Orléans zip: 45067 country: France name: Léa PARCOT, MD role: CONTACT phone: 02 38 22 97 17 phoneExt: +33 email: lea.pascot@chr-orleans.fr name: Léa PARCOT, MD role: PRINCIPAL_INVESTIGATOR lat: 47.90289 lon: 1.90389 facility: Anaesthesia - Intensive care city: Poitiers zip: 86021 country: France name: Denis FRASCA, MD role: CONTACT phone: 05 49 44 38 95 phoneExt: +33 email: denis.frasca@univ-poitiers.fr name: Denis FRASCA, MD role: PRINCIPAL_INVESTIGATOR lat: 46.58333 lon: 0.33333 facility: Anesthesia - intensive care city: Tours zip: 37044 country: France name: Francis REMERAND, MD role: CONTACT phone: 02 47 47 84 80 phoneExt: +33 email: F.REMERAND@chu-tours.fr name: Francis REMERAND, MD role: PRINCIPAL_INVESTIGATOR lat: 47.38333 lon: 0.68333 hasResults: False