hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06338657 id: 7H-23-5 id: NCI-2024-01367 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: 7H-23-5 type: OTHER domain: USC / Norris Comprehensive Cancer Center id: P30CA014089 type: NIH link: https://reporter.nih.gov/quickSearch/P30CA014089 briefTitle: FID-007 Followed by Standard of Care Surgery in Head and Neck Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-04 date: 2026-04-04 date: 2027-04-04 date: 2024-03-29 date: 2024-03-29 name: University of Southern California class: OTHER name: National Cancer Institute (NCI) briefSummary: This phase I trial studies on how the PEOX-based polymer encapsulated paclitaxel FID-007 (FID-007) affects the immune cells around the tumor patients with head and neck squamous cell carcinoma. The active drug in FID-007 is paclitaxel, an established chemotherapy drug that has been shown to kill cancer cells. FID-007 is a packaged form of paclitaxel using a polyethylozaxoline (PEOX) polymer which may allow the drug to reach deeper into tumors and less into normal cells by being smaller. This study is being done to help identify future treatment options and better understand how to improve outcomes of patients with head and neck cancers after surgery. conditions: Head and Neck Squamous Cell Carcinoma studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: Biospecimen Collection name: Computed Tomography name: Magnetic Resonance Imaging name: PEOX-based Polymer Encapsulated Paclitaxel FID-007 name: Tumor Resection measure: Evaluate the phenotypical and functional changes of different T cell subsets within the tumor microenvironment after treatment with FID-007 measure: Incidence of adverse events (AEs) measure: Major pathologic response rate measure: Complete pathologic response rate measure: Rate of locoregional recurrence measure: Rate of distant metastasis sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Los Angeles General Medical Center city: Los Angeles state: California zip: 90033 country: United States name: Sandy Tran, MS role: CONTACT phone: 323-865-0451 email: Sandy.tran@med.usc.edu name: Jacob S. Thomas, MD role: PRINCIPAL_INVESTIGATOR lat: 34.05223 lon: -118.24368 facility: USC / Norris Comprehensive Cancer Center city: Los Angeles state: California zip: 90033 country: United States name: Sandy Tran, MS role: CONTACT phone: 323-865-0451 email: Sandy.tran@med.usc.edu name: Jacob S. Thomas, MD role: PRINCIPAL_INVESTIGATOR lat: 34.05223 lon: -118.24368 hasResults: False
nctId: NCT06338644 id: HelwanUY briefTitle: Palbociclib in Metastatic Breast Cancer: Gene Polymorphism-based Study in Egyptian Patients. acronym: Palbociclib overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-09-01 date: 2026-09-01 date: 2024-03-29 date: 2024-03-29 name: Helwan University class: OTHER briefSummary: Cyclin-dependent kinase (CDK) 4/6 inhibitors are a class of agents recently introduced in the clinic for the treatment of advanced hormone receptor-positive (HR+) and HER2-negative (HER2-) BC. Palbociclib, ribociclib and abemaciclib have all been approved by the US Food and Drug Administration (FDA) and the European Medicines Agency among other regulatory bodies conditions: Hormone-receptor-positive Breast Cancer conditions: Human Epidermal Growth Factor 2 Negative Carcinoma of Breast conditions: Metastatic Breast Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Palbociclib measure: 1-year Progression free survival (PFS) measure: Neutropenia sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06338631 id: 43C301 briefTitle: Early Detection of Renal Abnormalities in Metabolically Healthy and Unhealthy Weight Excess" acronym: OB-KID overallStatus: RECRUITING date: 2023-08-01 date: 2025-12-31 date: 2025-12-31 date: 2024-03-29 date: 2024-03-29 name: Istituto Auxologico Italiano class: OTHER briefSummary: Overweight and obesity are increasingly prevalent worldwide. Weight excess increases the risk of in developing the metabolic syndrome, which is composed by a set of cardiometabolic risk factors such as abdominal adiposity, dyslipidemia, high blood pressure and elevated fasting glucose levels. Obesity and the metabolic syndrome are known to be risk factors for the development of chronic kidney disease. It is not clear however, whether they can be considered independent risk factors for impaired renal function and renal damage. Whereas obesity may represent an independent risk factor for renal damage, it is not clear yet if the contemporaneous presence of obesity and metabolic alterations is associated with an additional increase in the risk.
The secondary aim is to study the association between diet quality, consumption of ultra-processed foods and indicators of reduced renal function and renal damage. conditions: Obesity studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: Diet measure: Glomerular filtration rate measure: Microalbuminuria measure: Glycemia measure: Body mass index sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Istituto Auxologico Italiano, Città Studi ICANS status: RECRUITING city: Milano zip: 20100 country: Italy name: Alberto Battezzati, Prof role: CONTACT phone: +390261911 email: a.battezzati@auxologico.it lat: 45.46427 lon: 9.18951 facility: Programma Infradipartimentale di Dietoterapia nel Trapianto e nell' Insufficienza Renale Cronica, DAI di Medicina Interna ad Indirizzo Specialistico, del Policlinico Federico II di Napoli status: RECRUITING city: Naples country: Italy name: Bruna Guida, Prof. role: CONTACT lat: 40.85216 lon: 14.26811 hasResults: False
nctId: NCT06338618 id: 1532-N-23 briefTitle: Manual Therapy in Metabolic Liver Disease acronym: OSTEO-EHMet overallStatus: RECRUITING date: 2024-04-03 date: 2024-06 date: 2024-08 date: 2024-03-29 date: 2024-04-05 name: University of Seville class: OTHER briefSummary: Hepatic steatosis is a disease that is becoming more common in our society; approximately 40% of the population suffers from non-alcoholic fatty liver. The beneficial effect of manual therapy for the treatment of viscera dysfunctions such as the stomach or colon is known. The objective of this study is to demonstrate the anti-inflammatory effects of visceral manual therapy in patients with metabolic liver disease associated with non-alcoholic fatty liver. conditions: NAFLD, Non-alcoholic Fatty Liver Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 42 type: ESTIMATED name: liver treatment protocol measure: Hepatic steatosis index measure: FIB-4 index measure: NAFLD-fibrosis index measure: HOMA index measure: TyG index measure: Change from baseline in algometry measure: Visual analogue Scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Universitary Hospital Juan Ramón Jiménez status: RECRUITING city: Huelva zip: 21005 country: Spain name: Javer Carrasco Sánchez, Dr role: CONTACT phone: 682289772 email: fjcarrascos@icloud.com lat: 37.26638 lon: -6.94004 hasResults: False
nctId: NCT06338605 id: MEC-2023-0715 briefTitle: Evaluating the Incidence of Pseudo-Acute Kidney Injuries in Patients With Metastatic Breast Cancer on CDK4/6 Inhibitors Trough Cystatin C Analysis acronym: CYSTATINcDK4/6 overallStatus: ACTIVE_NOT_RECRUITING date: 2023-12-12 date: 2024-04-01 date: 2024-06-01 date: 2024-03-29 date: 2024-03-29 name: Erasmus Medical Center class: OTHER briefSummary: CDK4/6 inhibitors have led to an improvement of both progression free survival (PFS) and overall survival (OS) in patients with advanced estrogen positive (ER+)/HER2- breast cancer when applied in the first or second line of treatment. Despite the advantages of CDK4/6 inhibitors, these medications can lead to adverse effects. One of the adverse events observed across all types of CDK4/6 inhibitors is an elevation in creatinine levels. An elevation in plasma creatinine during treatment with abemaciclib is not always indicative of a reduction in renal function; it can also be attributed to the inhibition of active tubular secretion of creatinine. This phenomenon is known as pseudo acute kidney injury (pseudo-AKI).
The incidence of pseudo-AKI in patients using CDK4/6 inhibitors is currently unknown. A method to distinguish pseudo-AKI from AKI is measuring the level of an alternative filtration marker in blood, for example cystatin C. Cystatin C is also filtered at the glomerulus but not secreted intro the renal tubulus or reabsorbed into the bloodstream. Also, there is no affection by muscle mass or diet. In this study the investigators will explore the incidence of both AKI and pseudo-AKI in patients who are treated with CDK4/6 inhibitor treatment by assessing both creatinine and cystatin C in plasma. conditions: Advanced Breast Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 40 type: ESTIMATED name: no intervention, observational study of AKI under CDK4/6 inhibitor treatment measure: Pseudo-AKI in patients on CDK4/6 inhibitors measure: Pseudo-AKI in patients on CDK4/6 inhibitors per drug measure: AKI in patients measure: Influencing factors cystatin C levels sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Erasmus Medical Center city: Rotterdam country: Netherlands lat: 51.9225 lon: 4.47917 hasResults: False
nctId: NCT06338592 id: UUtah_00153806 briefTitle: The MyLungHealth Study Protocol: Engaging Patients to Enable Interoperable Lung Cancer Decision Support at Scale acronym: MyLungHealth overallStatus: RECRUITING date: 2024-03-28 date: 2025-03-27 date: 2025-12-31 date: 2024-03-29 date: 2024-04-04 name: University of Utah class: OTHER briefSummary: Early lung cancer screening (LCS) through low-dose computed tomography (LDCT) is crucial but underused due to various barriers, including incomplete or inaccurate patient smoking data in the electronic health record and limited time for shared decision-making. The objective of this trial is to investigate a patient-centered intervention, MyLungHealth, delivered through the patient portal. The intervention is designed to improve LCS rates through increased identification of eligible patients and informed decision making. conditions: Lung Cancer conditions: Lung Neoplasms/Diagnosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a patient randomized trial that includes two sub-studies, with 2 arms each. primaryPurpose: SCREENING masking: NONE count: 42415 type: ESTIMATED name: MyLungHealth name: DecisionPrecision+ measure: Study 1 primary outcome: Percentage of participants identified as eligible for LCS. measure: Study 2 primary outcome: Percentage of participants for whom LDCT was ordered. measure: Study 1 secondary outcome: Percentage of participants for whom LDCT was ordered. measure: Study 1 secondary outcome: Percentage of participants for whom LDCT was completed. measure: Study 2 secondary outcome: Percentage of participants for whom LDCT was completed. measure: Study 2 secondary outcome: Percentage of participants for whom LCS care gap was closed. sex: ALL minimumAge: 50 Years maximumAge: 79 Years stdAges: ADULT stdAges: OLDER_ADULT facility: NYU Langone Health status: RECRUITING city: New York state: New York zip: 10016 country: United States name: Devin Mann, MD role: CONTACT email: devin.mann@nyulangone.org name: Devin Mann, MD role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 facility: University of Utah Health status: RECRUITING city: Salt Lake City state: Utah zip: 84112 country: United States name: Kensaku Kawamoto, MD, PhD, MHS role: CONTACT email: kensaku.kawamoto@utah.edu name: Kensaku Kawamoto, MD, PhD, MHS role: PRINCIPAL_INVESTIGATOR lat: 40.76078 lon: -111.89105 hasResults: False
nctId: NCT06338579 id: 2023PPRC04 id: 2023-A01763-42 type: OTHER domain: IDRCB briefTitle: Overview of Self-medication Among French Navy Personnel acronym: AutoMMaN overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-03 date: 2026-04 date: 2024-03-29 date: 2024-03-29 name: Direction Centrale du Service de Santé des Armées class: OTHER briefSummary: The goal of this cross-sectional descriptive observational study is to assess the extent of self-medication among the crews of surface ships at the Toulon naval base. This study could include healthy volunteers, or participants with well-controlled chronic pathologies enabling them to be fit for embarkation, who are currently being deployed for at least 4 weeks on a surface ship at the naval base.
Participants will tick and complete a questionnaire (between 15 and 30 minutes) after 4 consecutive weeks on the ship. conditions: Self Medication studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 800 type: ESTIMATED name: Questionnaire measure: percentage of patients who have self-medication sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06338566 id: 2021PPRC10 id: 2023-A01975-40 type: OTHER domain: IDRCB briefTitle: Prospective Follow-up of the Results of Nail Arthrodesis of the Ankle acronym: PROCLOU overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-03 date: 2026-04 date: 2024-03-29 date: 2024-03-29 name: Direction Centrale du Service de Santé des Armées class: OTHER briefSummary: The goal of this prospective, single-center observational study is to describe the functional outcome of the surgical procedure in patient who undergone transplanted centromedullary nailing in the septic setting.
Patients will be asked to complete a questionnaire during follow-up consultations. conditions: Ankle Fractures studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED name: Follow-up measure: bony outcome of transcalcaneal nailing measure: functional result of the procedure sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06338540 id: A26020822 briefTitle: Relation of Caries Color to Caries Severity and Its Microbial Load overallStatus: ACTIVE_NOT_RECRUITING date: 2022-09-01 date: 2024-01-01 date: 2024-07-01 date: 2024-03-29 date: 2024-03-29 name: Mansoura University class: OTHER briefSummary: This study is to find the relation of caries color to caries severity and its microbial load in primary molars. conditions: Relation of Caries Color studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Group 1: Yellow caries color Group 2: dark brown caries color Group 3: light brown caries color Group 4: black caries color primaryPurpose: OTHER masking: NONE count: 80 type: ESTIMATED name: Black color of caries name: dark brown color of caries name: light brown color of caries name: yellow color of caries measure: Caries color related to history of pain measure: Caries color related to ICDAS measure: Caries color related to pulp exposed measure: Caries color related to microbial load sex: ALL minimumAge: 4 Years maximumAge: 7 Years stdAges: CHILD facility: Mansoura university city: Mansoura state: Dakahlia zip: 35511 country: Egypt lat: 31.03637 lon: 31.38069 hasResults: False
nctId: NCT06338527 id: 2024YX321 briefTitle: Effects of Aromatherapy on Patients Undergoing Chemotherapy for Breast Cancer overallStatus: NOT_YET_RECRUITING date: 2024-03-26 date: 2024-06-01 date: 2024-06-15 date: 2024-03-29 date: 2024-03-29 name: Weifang Medical University class: OTHER briefSummary: The objective of this study was to investigate the effects of aromatherapy on sleep quality and anxiety in patients undergoing chemotherapy for breast cancer. conditions: Sleep Quality conditions: Anxiety studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: Aromatherapy name: No intervention measure: Sleep quality measure: Anxiety sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Weifang People's Hospital city: Weifang state: Shangdong zip: 261000 country: China name: Shirong Fang, M.D. role: CONTACT email: fsr0536@163.com lat: 36.71 lon: 119.10194 hasResults: False
nctId: NCT06338514 id: KutahyaHSU-DRYNEEDLE-dorsalgia briefTitle: The Effectiveness of Dry Needling Treatment in Patients Diagnosed With Dorsal Myofascial Pain Syndrome. overallStatus: NOT_YET_RECRUITING date: 2024-03-25 date: 2024-06-25 date: 2024-06-25 date: 2024-03-29 date: 2024-03-29 name: Kutahya Health Sciences University class: OTHER briefSummary: Back pain is commonly seen in the working-age population, with the peak occurrence around the age of 40. Its frequency does not increase with age and is not associated with age-related degenerative changes in the spine. Especially when the underlying cause is conditions such as myofascial pain syndrome (MPS), where regional muscle sensitivity in the rhomboid and trapezius areas is prominent, dry needling treatment has become increasingly popular and the subject of numerous studies in recent years. In the diagnosis of MPS, two valuable findings include the detection of a taut band upon palpation and the presence of trigger points in muscle fibers with mild finger pressure. The study we are planning involves a double-blind efficacy trial where real and sham dry needling procedures will be performed under ultrasound guidance, ensuring that both the patient and the evaluator are blinded. This study design has the potential to make a significant contribution to the literature in this field. conditions: Myofascial Trigger Point Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A two-group, sham-controlled, double-blind, prospective, randomized controlled trial primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: In the dry needling application, patients will be blinded to the groups they are randomized into. The evaluator will also be unaware of which group the patients belong to. The practitioner will perform the procedures in both groups using ultrasound guidance, targeting the standard trigger points in the painful dorsal trapezius and rhomboid muscles in the study group, and targeting subcutaneous fatty tissue in the same regions in the sham group. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Real dry needling name: Sham dry needling measure: Visual Analog Scale measure: Patient-Specific Functional Scale measure: Pressure Pain Threshold Measurement measure: What does Oswestry stand for? The Oswestry Disability Index (ODI) measure: The 12-item Short-Form Health Survey version 2 (SF-12v2) sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06338501 id: 77325224.4.0000.5235 briefTitle: Assessment of Heart Rate Variability, Performance and Dehydration in Muay Thai Athletes overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2025-06-30 date: 2025-06-30 date: 2024-03-29 date: 2024-03-29 name: Centro Universitário Augusto Motta class: OTHER briefSummary: Known as "Thai boxing," Muay Thai utilizes a combination of upper limb strikes (such as punches and elbow strikes) as well as lower limb strikes (such as kicks and knee strikes), and is thus referred to as the "art of eight limbs." It is practiced worldwide and is a prominent discipline in many mixed martial arts (MMA) training camps. In this sport, training load control involves monitoring and adjusting the quantity and intensity of training according to each athlete's capacity. In the context of combat sports, such as Muay Thai, heart rate variability (HRV) and assessment of body composition by bioelectrical impedance analysis can be used as tools to evaluate training responses. Additionally, HRV can also serve as a tool for assessing recovery after training or competition. If HRV does not return to baseline after training or competition, it may be a sign that the athlete is not fully recovered and may need more time to recuperate before returning to training or competition. Due to the absence of studies in the literature that have assessed a possible association between HRV and dehydration and rehydration processes in amateur Muay Thai athletes, it becomes essential to evaluate this correlation. Given the growing interest in practicing Muay Thai in gyms, assessing the sympathetic-vagal balance, body composition, and performance of these athletes becomes of utmost importance. Therefore, the aim of this study is to investigate the relationship between dehydration indicators, HRV parameters, and performance in the frequency speed kick test (FSKT). Participants will be assessed before and after an eight-week training program, conducted three times a week. Assessments will include resting HRV measurement and FSKT; in addition, bioimpedance will be used to estimate the body composition of participants pre- and post-training. It is expected that the results will reveal changes in HRV, performance, and body composition of the athletes after training. conditions: Nervous System Diseases conditions: Dehydration studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 36 type: ESTIMATED name: Specifical Functional Training Exercises measure: HRV during specifical physical test measure: Correlation with BIA analysis, HRV and Specific Physical Test sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False