hackint0sh/New-Dataset huggingface dataset:
2. To design, implement and evaluate a nutrition program targeting the hospitalized diabetic population. The investigators will prospectively randomize the target population into either a nutrition program (Intervention), or state-of-art standard of care (SOC) in a 4:1 ratio. Participants in the intervention group will be provided the following two resources in addition to SOC: 1) Enhanced access to nutritious food (twice daily meal delivery up to 90 days post-discharge) 2) Education at discharge and continuing outreach to enhance knowledge for better diet and food options.
3. To enhance community engagement and develop a systematic implementation plan for long-term roll-out of the nutrition program. conditions: Diabetes Mellitus, Type 2 conditions: Food Insecurity conditions: Diabetes Mellitus, Type 1 studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants will be prospectively randomized into either a nutrition program (intervention), or receiving state-of-the-art standard of care (SOC) in a 4:1 ratio. Patients in the intervention group will be provided the following two resources in addition to SOC:
2. Education at discharge and continuing outreach to enhance knowledge for better diet and food options primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 160 type: ESTIMATED name: Nutrition program measure: Food insecurity at 30-days post initial discharge measure: Food insecurity at 60- and 90- days post post initial discharge measure: Measures of diabetes stress measure: Measures of hypoglycemia measure: Measures of medication adherence measure: Hospitalization sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06329362 id: 2-7-23 briefTitle: Minimally Invasive Ridge Splitting Versus the Conventional Open Flap Technique overallStatus: RECRUITING date: 2023-07-31 date: 2025-07 date: 2025-07 date: 2024-03-25 date: 2024-03-26 name: The Royal College of Surgeons of Edinburgh class: OTHER briefSummary: The goal of this clinical trial is to compare implant stability, and crestal bone loss, when using minimal invasive ridge splitting versus convenient open flap technique. The main question is Does Minimal Invasive Implant ridge splitting ("transmucosal" without flap) influence the implant stability and crystal bone loss, when compared with the conventional open flap techniques? Researchers will compare Group A: Minimal Invasive Implant ridge splitting and Group B: Triangular flap technique is used to see if there is significant difference between the two groups when measuring implant stability, and crestal bone density. conditions: Alveolar Bone Loss studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 16 type: ESTIMATED name: Minimally invasive implantation name: Open flap procedure for ridge expansion. measure: Implant stability. measure: CBCT assessment measure: Postoperative Pain measure: Operation Time sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Dentistry Cairo University status: RECRUITING city: Cairo zip: 35855 country: Egypt name: Bassem Emad, MDs role: CONTACT phone: +201001113474 email: bassem_26@hotmail.com name: Emad Deif, Prof role: CONTACT phone: +201222331938 email: daif_emad@yahoo.com lat: 30.06263 lon: 31.24967 facility: Future Dental Academy GmbH status: RECRUITING city: Flonheim state: Rheinland - Pfalz zip: D-55237 country: Germany name: Armin Nadjet, A.Prof role: CONTACT phone: +4915115253692 email: nedjat@t-online.de name: Rainer Zoppke role: CONTACT phone: +491778339601 email: Rainer.Zoppke@champions-implants.com lat: 49.785 lon: 8.04 hasResults: False
nctId: NCT06329349 id: EK VP57/0/2023 briefTitle: Metabolic Flexibility to Predict Lifestyle Interventions Outcomes acronym: MEPHISTO overallStatus: RECRUITING date: 2024-01-02 date: 2025-12-12 date: 2026-04-01 date: 2024-03-25 date: 2024-03-25 name: Charles University, Czech Republic class: OTHER name: Ministry of Health, Czech Republic name: EXCELES LX22NPO5104, CarDia briefSummary: Weight loss is a cornerstone of diabetes (T2D) management, yet in clinical practice, its delivery is limited by its perceived burdensome nature and variability in response. Personalization of the interventions to increase their success rate is an unmet clinical need. The proposed project MEPHISTO (Whole body and gut microbiome metabolic flexibility to predict lifestyle intervention outcomes) would aim to identify predictive features related to successful weight loss upon sequential exercise and diet intervention in people living with obesity. To this end, the study aims to conduct a clinical trial where the investigators would implement state-of-the-art physiological phenotyping of metabolic flexibility at the whole-body level and at the level of the gut in persons with obesity before and after exercise and diet + exercise intervention to identify predictive signatures of successful weight loss conditions: Obesity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 2:1 randomized cross-over primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Exercise name: Combined Exercise + Diet measure: Change in metabolic flexibility (MetFlex (ΔRQ 200-0)) measure: Change in insulin sensitivity measure: Glucose tolerance relate to primary outcomes changes measure: HbA1c relate to primary outcomes changes measure: Insulin sensitivity relate to primary outcomes changes measure: Microbiome composition relate to weight loss: exploratory outcome measure: Metabolomic signatures relate to weight loss: exploratory outcome sex: FEMALE minimumAge: 25 Years maximumAge: 45 Years stdAges: ADULT facility: University Hospital Kralovske Vinohrady status: RECRUITING city: Prague zip: 10034 country: Czechia name: Jan Gojda, PhD role: CONTACT phone: +420267163031 email: jan.gojda@lf3.cuni.cz name: Katerina Koudelkova, MD role: CONTACT phone: +420267163031 email: katerina.koudelkova@fnkv.cz lat: 50.08804 lon: 14.42076 facility: Third Medical Faculty,Charles University status: RECRUITING city: Prague zip: 10084 country: Czechia name: Michaela Šiklová, PhD role: CONTACT phone: +420267102222 email: michaela.siklova@lf3.cuni.cz name: PhD role: CONTACT phone: +420267163031 email: jan.gojda@lf3.cuni.cz lat: 50.08804 lon: 14.42076 facility: Faculty of Sports Science status: RECRUITING city: Prague zip: 16000 country: Czechia name: Michal Šteffl, PhD role: CONTACT phone: +420220172072 email: michal.steffl@ftvs.cuni.cz name: Tomáš Větrovský, PhD role: CONTACT phone: +420220172072 email: tomas.vetrovsky@ftvs.cuni.cz lat: 50.08804 lon: 14.42076 hasResults: False
nctId: NCT06329336 id: STUDY00019653 id: UL1TR002319 type: NIH link: https://reporter.nih.gov/quickSearch/UL1TR002319 briefTitle: Parenting Support for Justice Involved Families overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-03-30 date: 2025-04 date: 2024-03-25 date: 2024-04-24 name: University of Washington class: OTHER name: National Center for Advancing Translational Sciences (NCATS) briefSummary: Together with the Community Care Team of King County Community Partnership for Transition Solutions (KCCPTS), the investigators propose to collaborate in adapting parenting intervention(s) to support the well-being and effective parenting of parents re-entering the community, as well as that of their children's primary caregiver. The aim is promoting the well-being of the parents/caregivers and their children, fostering positive child development, and ultimately, preventing the intergenerational transmission of adversity. The KCCPTS Community Care Team includes re-entry navigators who have lived experience of adversity and incarceration, bringing their unique insights regarding the re-entry experience, from both personal and professional experiences. This study will evaluate a task-sharing approach to offering formerly incarcerated parents and their families a parenting support intervention. That is, re-entry navigators will be trained to deliver evidence-based parenting interventions. This increases the feasibility and accessibility of the program, particularly because facilitators have shared experiences and trusted connections with their clients. This project proposes four main activities: 1) conduct focus groups with parents re-entering the community to better understand their parenting needs, 2) work with KCCPTS re-entry navigators to incorporate information from their experience and the focus group to adapt a parenting intervention, 3) train re-entry navigators to deliver the program, and 4) conduct a preliminary evaluation of the impact of the program on parents' well-being and parenting when the program is delivered by KCCPTS re-entry navigators. If this preliminary evaluation shows promise in supporting parent well-being and parenting effectiveness, the investigators will seek funding to conduct a larger, more rigorous evaluation. conditions: Parenting conditions: Well-Being, Psychological conditions: Mental Health Wellness 1 studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 40 type: ESTIMATED name: Social Emotional Competence for Children and Parents measure: Parenting Behavior Inventory - Very short Form measure: PHQ-9 Depressive Symptoms measure: GAD-7 Anxiety Symptoms measure: Brief Resilience Scale measure: Self-Compassion Scale - Short Form measure: Strengths and Difficulties Questionnaire sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06329323 id: 23CX8477 briefTitle: SerUm and Plasma MicroRNAs in Malignant Ovarian gERm Cell Tumours acronym: SUMMER overallStatus: NOT_YET_RECRUITING date: 2024-04-14 date: 2027-04 date: 2028-04 date: 2024-03-25 date: 2024-03-26 name: Imperial College London class: OTHER briefSummary: The goal of this observational case-control study is to learn about the circulating and tissue microRNA expression, imaging and radiomic profiles of malignant ovarian germ cell tumours (MOGCT) compared to patients with a benign OGCT and no ovarian pathology.
Researchers will compare the circulating miRNA profile of patients with a benign ovarian germ cell tumour and no ovarian pathology to see where the differences lie. If a patient with a BOGCT requires surgery, a pathology sample will be taken from the main tumour specimen. Radiomic analysis will take place on existing ultrasound images of their benign mass. conditions: Germ Cell Ovarian Cancer conditions: Germ Cell Tumor conditions: Germ Cell Cancer conditions: Germ Cell Neoplasia conditions: Ovary Cancer conditions: Ovary Neoplasm conditions: Ovarian Cancer conditions: Ovarian Neoplasms studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 24 type: ESTIMATED name: Blood test name: Pathology specimen miRNA expression measure: Difference in microRNA expression (plasma) between benign and malignant masses measure: Difference in microRNA expression (serum) between benign and malignant masses measure: microRNA expression (plasma) measure: microRNA expression (serum) measure: Quantitative measure of circulating miRNA before treatment measure: Quantitative measure of circulating miRNA before treatment measure: Quantitative measure of circulating miRNA after treatment measure: Quantitative measure of circulating miRNA after treatment measure: Performance of segmentation model on ultrasound images measure: Performance of segmentation model on MRI images measure: Performance of classification model on ultrasound images measure: Performance of classification model on MRI images sex: FEMALE minimumAge: 16 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06329310 id: XEL-CR-14 briefTitle: Xeltis Hemodialysis Access Conduit: aXess-E Study overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2025-06 date: 2026-12 date: 2024-03-25 date: 2024-03-25 name: Xeltis class: INDUSTRY briefSummary: A prospective, single arm, non-randomized feasibility study to confirm the safety and performance of the Xeltis Hemodialysis Access conduit, aXess-E, in subjects older than 18 years with end-stage renal disease, who plan to undergo hemodialysis for at least the first 6 months after study access creation. conditions: End Stage Renal Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: aXess-E conduit measure: Primary Patency rate measure: Freedom from device-related SAE measure: Implantation success rate measure: Primary patency rate measure: Primary assisted patency rate measure: Secondary patency rate measure: Functional patency rate measure: Time (expressed in months) to first intervention and to access abandonment measure: Rate of access-related interventions required to achieve/maintain patency measure: Freedom from device-related SAE measure: Rate of access site infections measure: Proportion of hemodialysis sessions completed via central venous catheter (CVC) during the first 12 months of access creation and access cannulation, irrespective of access abandonment measure: Time to first cannulation measure: Following first cannulation, number of days with CVC in situ (catheter contact time) irrespective of access abandonment sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06329297 id: NUR23-1005 INPTCGM1 briefTitle: Continuous Glucose Monitoring in Inpatients overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-08 date: 2025-04 date: 2024-03-25 date: 2024-03-25 name: Parkview Health class: OTHER briefSummary: The purpose of this study is to contribute to current research regarding the feasibility and accuracy of CGM in the hospital setting for both the medical and cardiovascular intensive care (ICU) patient populations. conditions: Hyperglycemia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 80 type: ESTIMATED name: CGM monitor measure: CGM vs point of care test (POCT) glucose measure: Slow downward trend arrow on CGM device sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06329284 id: RC 31.1.2024 briefTitle: Midkine Role With Deregulated Oxidative and Immune Milieu in Induction of Preeclampsia overallStatus: COMPLETED date: 2023-01-01 date: 2023-09-15 date: 2023-12-15 date: 2024-03-25 date: 2024-03-26 name: Benha University class: OTHER briefSummary: Preeclampsia (PE) is a hypertensive pregnancy-related disorder that endangers maternal and fetal outcomes and accounts for 9-10% of maternal mortalities with its early-onset phenotype is the most dangerous, but its etiology is still not fully elucidated.
Midkine (MDK) is a multifunctional protein that plays a unique role in the development of hypertension (HTN), via its proatherogenic effect and induction of overexpression of angiotensin converting enzyme. Oxidative stress (OS) upregulates the expression of MDK and MDK induces propagation of neoangiogenesis and acts as chemotactic for neutrophils. conditions: Pre-Eclampsia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Newly pregnant normotensive (NT) women with singleton fetus primaryPurpose: DIAGNOSTIC masking: NONE count: 80 type: ACTUAL name: ELISA measure: Severity of Pre-Eclampsia (PE) sex: FEMALE minimumAge: 21 Years maximumAge: 50 Years stdAges: ADULT facility: Banha University city: Banhā state: El- Qalyobia zip: 13511 country: Egypt lat: 30.45906 lon: 31.17858 hasResults: False
nctId: NCT06329271 id: 113022-E briefTitle: After Hip Fracture Nailing, Compare Early Weight Bearing as Tolerated (WBAT) Group With Weight Bearing Restriction(WBR) overallStatus: RECRUITING date: 2024-03-08 date: 2025-04-29 date: 2025-04-29 date: 2024-03-25 date: 2024-03-25 name: Far Eastern Memorial Hospital class: OTHER briefSummary: Purpose: Proximal femur fracture is a major traumatic injury in elderly populations; however, practical postoperative weight-bearing protocols are lacking. Therefore, the purpose of the present study was to investigate whether early weight-bearing status after proximal femur nail fixation is associated with any loss of reduction and evaluate the clinical outcomes of this intervention.
For this prospective single-center clinical trial study, we recruited 60 geriatric proximal femur fracture cases, classified by AO/OTA 2018, receiving intramedullary nail fixation. The participants were assigned to the Early-weight-bearing group (n= 30) or the Weight-bearing restriction group (n = 30). Clinical outcomes included the Harris functional hip score and VAS pain score. Additionally, demographic data, radiological parameters, time to weight-bearing, mortality rate, medical and surgical complications, and final ambulation status were recorded. conditions: Bony Weight Bearing Disorder studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Early-Weight bearing measure: Harris Hip Functional score measure: Harris Hip Functional score measure: Harris Hip Functional score measure: Harris Hip Functional score measure: Harris Hip Functional score measure: Visual analog pain score measure: Visual analog pain score measure: Visual analog pain score measure: Visual analog pain score measure: Visual analog pain score measure: Complication sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Far-Eastern Memorial Hospital status: RECRUITING city: New Taipei City zip: 220 country: Taiwan name: Yen Cheng Chen role: CONTACT phone: 886919207805 email: sstteevveepp@gmail.com lat: 25.01111 lon: 121.44583 hasResults: False
nctId: NCT06329258 id: PTC09 briefTitle: Combination of Sotyktu and Enstilar for Plaque Psoriasis overallStatus: COMPLETED date: 2022-12-06 date: 2023-11-13 date: 2023-11-13 date: 2024-03-25 date: 2024-03-25 name: Psoriasis Treatment Center of Central New Jersey class: OTHER briefSummary: combination deucravacitinib and enstilar foam conditions: Psoriasis studyType: INTERVENTIONAL phases: PHASE4 allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescription: open label primaryPurpose: TREATMENT masking: NONE count: 30 type: ACTUAL name: Enstilar name: Deucravacitinib measure: Psoriasis Area and Severity Index 75 at week 12 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Schweiger Derm Group city: East Windsor state: New Jersey zip: 08520 country: United States lat: 40.268 lon: -74.54043 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2021-08-30 uploadDate: 2024-03-14T10:41 filename: Prot_SAP_000.pdf size: 834542 hasResults: False
nctId: NCT06329245 id: brainpro2022 briefTitle: Development of Prosocial Behaviors and Related Brain Network in Infants of High and Low Risk of ASD overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2029-01-01 date: 2029-07-01 date: 2024-03-25 date: 2024-03-25 name: Children's Hospital of Fudan University class: OTHER name: ShanghaiTech University briefSummary: The goal of this observational study is to compare the developmental trajectories of prosocial behaviors and functional network connections in infants and toddlers at high and low risk of autism spectrum disorder (ASD). The main questions it aims to answer are what the differences in prosocial behaviors and related brain network connections between infants/toddlers at high and low risk of ASD are. Participants will receive developmental and social communicational assessments (Griffiths Mental Developmental Scales, Peabody Developmental Motor Scales, The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist), resting-state EEG and MRI in a natural sleeping state. conditions: Autism or Autistic Traits conditions: Healthy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Do not take any interventions measure: clinical diagnosis measure: neurodevelopmental outcome measure: Prosocial behaviors measure: nuclear magnetic resonance imaging(MRI) measure: Event related potentials (ERPs) sex: ALL minimumAge: 0 Months maximumAge: 18 Months stdAges: CHILD hasResults: False
nctId: NCT06329219 id: wIRA briefTitle: Water-filtered Infrared-A Radiation in Patients With Hand Osteoarthritis overallStatus: RECRUITING date: 2024-03-26 date: 2025-02-28 date: 2025-12 date: 2024-03-25 date: 2024-03-28 name: Charite University, Berlin, Germany class: OTHER briefSummary: The aim of this clinical trial is to evaluate the effects of water-filtered Infrared-A radiation on patients suffering from hand osteoarthritis. The main questions it aims to answer are:
* Are patients satisfied with the treatment results when compared to those who were on a wait-list? conditions: Hand Osteoarthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 70 type: ESTIMATED name: water-filtered Infrared-A radiation measure: Pain in the finger joints on visual analogue scale measure: Hand Dynamometer measure: Disabilities of Arm, Shoulder and Hand (DASH) questionnaire measure: Pain Self-Efficacy Questionnaire measure: Hospital Anxiety and Depression Scale (HADS) measure: Short Form (SF)-36 Health Survey (SF-36) measure: Functional Index for Hand OsteoArthritis (FIHOA) measure: Tolerability of the intervention measure: Pain medication (number per day) sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Charité - Universitätsmedizin Berlin at the Department of Internal and Integrative Medicine, Immanuel Krankenhaus Berlin status: RECRUITING city: Berlin-Wannsee state: Berlin zip: 14109 country: Germany name: Miriam Rösner role: CONTACT phone: +49 30 80505 682 email: naturheilkunde.studien@immanuel.de lat: 52.41915 lon: 13.15531 hasResults: False
nctId: NCT06329206 id: GH2616-101 briefTitle: A Phase Ia/Ib Study of GH2616 Tablet in Subjects With Advanced Solid Tumors overallStatus: RECRUITING date: 2024-03-13 date: 2026-04-25 date: 2026-09-01 date: 2024-03-25 date: 2024-04-03 name: Suzhou Genhouse Bio Co., Ltd. class: OTHER name: Zhejiang Cancer Hospital name: Henan Cancer Hospital name: Hubei Cancer Hospital name: The First Affiliated Hospital of Zhengzhou University briefSummary: This is a Phase Ia/Ib, dose escalation and dose expansion study to evaluate the safety, tolerability, PK, pharmacodynamics (PD) and preliminary efficacy of GH2616 Tablet in subjects with advanced solid tumors. It includes two parts: the dose escalation study (Phase Ia) and the dose expansion study (Phase Ib). conditions: Advanced Solid Tumors studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 156 type: ESTIMATED name: GH2616 Tablets measure: Safety assessment measure: Objective response rate (ORR) measure: Progression-free survival (PFS) measure: Duration of response (DOR) measure: Plasma concentration (Cmax) measure: Area under the plasma concentration-time curve (AUC) measure: Time to achieve Cmax (Tmax) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Zhejiang Cancer Hospital status: RECRUITING city: Zhejiang country: China name: ZHENGBO SONG, DOCTORATE role: CONTACT phone: +8613857153345 email: zjccgcp_phase1@126.com hasResults: False