hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06380634 id: NYalcinbas briefTitle: The Effectiveness of Motivational Interviewing in Reducing the Use of Household Chemicals and Personal Care Products During Pregnancy overallStatus: COMPLETED date: 2023-01-23 date: 2023-12-31 date: 2024-02-20 date: 2024-04-24 date: 2024-04-24 name: Istanbul University - Cerrahpasa (IUC) class: OTHER briefSummary: Objective: The aim of the study is to examine the effect of motivational interviewing on reducing the use of household chemicals and personal care products during pregnancy. conditions: Motivational Interview conditions: Cosmetic Product Causing Toxic Effect studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: The research was conducted in a prospective pre-test, post-test based randomized controlled experimental research design. primaryPurpose: SCREENING masking: NONE maskingDescription: The groups were randomized into 2 groups using a web-based randomization program (http://www.randomizer.org). The researcher included pregnant women who met the inclusion criteria in the outpatient clinics on certain days of the week, in accordance with the randomization process. count: 130 type: ACTUAL name: Experimental group- Motivational Interview measure: Evaluation Form for Use of Domestic Chemicals and Personal Care Products measure: Self Efficacy Competence Scale measure: Endocrine Disruptors Attitude Scale sex: FEMALE minimumAge: 20 Years maximumAge: 43 Years stdAges: ADULT facility: Istanbul University Cerrahpasa city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2024-02-05 uploadDate: 2024-04-17T16:09 filename: Prot_000.pdf size: 142041 typeAbbrev: SAP hasProtocol: False hasSap: True hasIcf: False label: Statistical Analysis Plan date: 2024-02-05 uploadDate: 2024-04-17T16:13 filename: SAP_001.pdf size: 234444 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-12-30 uploadDate: 2024-04-17T16:05 filename: ICF_002.pdf size: 75804 hasResults: False
nctId: NCT06380621 id: IRC/1386/018 briefTitle: Bilateral vs Unilateral Totally Extraperitoneal Repair Among Patients With Unilateral Inguinal Hernia overallStatus: COMPLETED date: 2018-03-15 date: 2019-02-15 date: 2019-03-15 date: 2024-04-24 date: 2024-04-24 name: B.P. Koirala Institute of Health Sciences class: OTHER briefSummary: The goal of this clinical trial is to investigate the feasibility of bilateral laparoscopic exploration for all unilateral cases followed by laparoscopic bilateral TEP repair in all cases with a contralateral occult hernia and to compare complications, recurrence rates, postoperative pain, and operative duration with prospectively performed unilateral repairs in young to middle-aged patients presenting with unilateral hernias in the surgery outpatient department.
* Incidence of occult contralateral hernia Patients attending the OPD for unilateral inguinal hernia were counseled about the trial and fully encouraged to understand the difference between two procedures for unilateral hernia: bilateral exploration and bilateral TEP repair, upon which if a contralateral occult inguinal hernia was observed, documented, and controls were taken from the patients who denied bilateral exploration and underwent unilateral TEP repair. The allotment of patients was done in two groups of 30 patients each.
Researchers will compare Group A( bilateral TEP) with Group B (unilateral TEP) to see if complications, recurrence rates, postoperative pain, and operative duration occur in each group conditions: Inguinal Hernia studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ACTUAL name: Totally Extra Peritoneal repair (TEP) repair measure: To compare pain in between patients of bilateral totally extra peritoneal repair and unilateral totally extra peritoneal repair. measure: To measure incidence of intra- and post-operative complication between patients of unilateral and bilateral TEP repair sex: ALL minimumAge: 16 Years maximumAge: 55 Years stdAges: CHILD stdAges: ADULT facility: Bikash Kumar Sah city: Dharān Bāzār state: Koshi zip: 56700 country: Nepal lat: 26.81248 lon: 87.28355 typeAbbrev: Prot_ICF hasProtocol: True hasSap: False hasIcf: True label: Study Protocol and Informed Consent Form date: 2018-03-15 uploadDate: 2024-04-21T09:41 filename: Prot_ICF_000.pdf size: 450800 hasResults: False
nctId: NCT06380608 id: 0047-23-ASF briefTitle: Levels of Fear, Anxiety and Wound Healing Among Aental Surgery Patients Under Local Versus General Anesthesia overallStatus: RECRUITING date: 2023-09-01 date: 2024-09-30 date: 2024-12-31 date: 2024-04-24 date: 2024-04-24 name: Zoya Haitov Ben Zikri class: OTHER_GOV briefSummary: Tooth extraction is one of the most common procedures in dentistry. Surgical extraction of damaged wisdom teeth involves bone resection and injury to the soft tissue. Dental care often evokes high levels of anxiety.In addition, stress causes poor regulation of endocrine, autocrine and paracrine systems during the three stages of wound healing of the soft oral tissues. Therefore, special considerations are necessary when performing dental surgery on highly stressed patients. One of the options used in the last decade is to perform this procedure under general anesthesia.
The aim of the study is to assess the level of anxiety/fear and monitor the wound healing process among patients who are about to undergo surgery to remove wisdom teeth or no more than 3 jaw implants under local anesthesia in the dental clinic compared to patients who are about to undergo the same surgery under general anesthesia. conditions: Wisdom Teeth Extraction or Jaw Implant studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 46 type: ESTIMATED name: Local anesthesia name: General anesthesia measure: Fear and anxiety measure: Wound heeling sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shamir (Asaf Harofe) Medical center status: RECRUITING city: Be'er Ya'aqov zip: 60930 country: Israel name: sara Bar Yehuda, MD role: CONTACT phone: 972528981004 email: sarabar1@shamir.gov.il lat: 31.93864 lon: 34.83749 hasResults: False
nctId: NCT06380595 id: 23 -1533 briefTitle: Complex EVAR in Inflammatory and Infective Abdominal and Thoracoabdominal Aortic Aneurysms acronym: CEVARII overallStatus: ENROLLING_BY_INVITATION date: 2024-02-21 date: 2025-03 date: 2026-03 date: 2024-04-24 date: 2024-04-24 name: CEVARII class: OTHER name: University of Iowa name: University of Colorado, Denver name: University of Trieste name: University of Copenhagen name: University of Colorado, Colorado Springs briefSummary: Complex endovascular aortic repair in inflammatory and infective perivisceral abdominal aortic aneurysms and thoracoabdominal aortic aneurysms (CEVARII) study is a collaborative international effort among vascular surgeons to establish a database on the global experience in the management of INAAs and IAAs. Ethical approval for the study was obtained from the Colorado Multiple Institutional Review Board (COMIRB) under protocol number 23-1533. conditions: Inflammatory Abdominal Aortic Aneurysm conditions: Aneurysm, Infected conditions: Aneurysm, Mycotic conditions: Abdominal Aortic Aneurysm conditions: Thoracoabdominal Aortic Aneurysm studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 220 type: ESTIMATED name: Complex endovascular aortic repair (cEVAR) measure: Primary Graft Patency measure: Bowel Ischemia measure: Presence of aortic aneurysm endoleak after surgery measure: Aneurysm-related mortality (ARM) measure: Conversion to Open Surgical Repair (OSR) measure: Aortic rupture measure: Post-operative infection-related complication (IRC) measure: The duration of preoperative, perioperative, and postoperative duration of anti-microbial or immunosuppressive pharmacologic therapies. measure: Assessment of Adverse Events (AEs) described in the protocol. measure: All Cause Mortality measure: Continued Aortic sac growth. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Colorado Healthcare city: Aurora state: Colorado zip: 80045 country: United States lat: 39.72943 lon: -104.83192 hasResults: False
nctId: NCT06380582 id: NL85595.068.23 briefTitle: Indoor Air Quality, Temperature and Cognitive Performance acronym: AEOLUS overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2024-12-21 date: 2024-12-21 date: 2024-04-24 date: 2024-04-24 name: Maastricht University Medical Center class: OTHER briefSummary: Study design: A cross-over single-blinded treatment design will be used. Participants will undergo 4 different conditions: (1) low air flow and 23°C, (2) low air flow and 35°C, (3) high air flow and 23°C, and (4) high air flow and 35°C. Participants will be blinded to the air quality level; however, it is not possible to blind them to the temperature condition, as they will be able to perceive it as different.
Intervention (if applicable): Each participant undergoes 4 conditions in randomized order. Two conditions consist of poor air quality defined as 3,000 ppm carbon dioxide and 23°C or 35°C temperature, respectively. conditions: Indoor Air Quality, Temperature and Cognitive Performance studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 22 type: ESTIMATED name: Temperature and Airflow combination measure: Cognition measure: Cognition measure: Heart Rate (bpm) measure: Metabolic Rate (ml/kg/min) measure: Blood Pressure (mmHg) measure: Blood samples measure: Saliva samples measure: Breathing rate measure: Temperature (C) measure: Humidity % measure: Carbon dioxide (CO2) concentration (ppm) sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT hasResults: False
nctId: NCT06380569 id: E-1139-21 Community Setting briefTitle: A Strength-Based Intervention to Improve Job Interview Skills in Young Adults in a Community Setting overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-06-01 date: 2025-12-01 date: 2024-04-24 date: 2024-04-24 name: Kessler Foundation class: OTHER briefSummary: We are looking to evaluate how effective a strength-based intervention may be in improving job interview skills in young adults. We are examining the effects of this intervention in young adults who may have difficulty with job interviews, and who may want to improve these skills. conditions: Autism Spectrum Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescription: Kessler Foundation Strength Identification and Expression (KF-STRIDE®) primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: KF-STRIDE® measure: Mock Job Interview measure: Employment Status measure: Time-to-reach Employment measure: Strength Knowledge and Strengths Use Scale (SKUS) measure: Youth Interview- Self Efficacy and Anxiety measure: Job Search Behavior Scale measure: Work Readiness Scale measure: Global Assessment of Character Strengths (GACS) measure: Rosenberg Self-Esteem Scale (RSES) sex: ALL minimumAge: 14 Years maximumAge: 26 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06380556 id: 25.05.2022/68 briefTitle: The Effect of Mechanical Vibration and ShotBlocker on Pain Levels During Heel Lance in Healthy Term Neonates overallStatus: COMPLETED date: 2022-11-10 date: 2023-01-30 date: 2023-07-13 date: 2024-04-24 date: 2024-04-24 name: Istanbul Medeniyet University class: OTHER briefSummary: This study was conducted to determine the effect of mechanical vibration and ShotBlocker methods on pain level, crying time and procedure time during heel prick blood collection in healthy term infants. conditions: Procedural Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: In the study, participants were assigned to groups by block randomization. Type of delivery (vaginal and cesarean section), gender (male and female) and birth weight (2500-3000 g, 3001-3500 g, 3501 and above) variables were used for block randomization. Blocks were repeated three times in each group and 36 participants were assigned to each. A randomization list with 2 X 2 X 3 X 3 blocks was developed using an online randomization tool. In the study, the group to which the first participant was assigned was determined by a sealed envelope method. primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: Using the block randomization technique, participants were divided into three groups. A web-based randomization list generation tool was used to assign participants to groups. Control and intervention groups were coded as A, B and C using the sealed envelope method. Randomization information was withheld from the researcher involved in data collection until data was collected. The researcher determines which group each baby is in. The researcher found out during the painful procedure. (investigator blinding).
To avoid statistical bias, study groups were coded as A, B and C; statistical blinding was performed (statistician blinding). whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 108 type: ACTUAL name: ShotBlocker name: Mechanical vibration measure: Procedural pain score- Neonatal Infant Pain Scale (NIPS) measure: Crying time measure: Procedure time sex: ALL minimumAge: 38 Weeks maximumAge: 42 Weeks stdAges: CHILD facility: Istanbul Medeniyet University city: Istanbul state: Kadıköy zip: 34720 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06380543 id: BILINCE briefTitle: ERCP Biliary Cannulation Success Using ESGE Algorithm acronym: BILINCE overallStatus: RECRUITING date: 2019-12-12 date: 2024-10-31 date: 2024-12-31 date: 2024-04-24 date: 2024-04-24 name: IRCCS San Raffaele class: OTHER name: Societa Italiana di Endoscopia Digestiva briefSummary: Papillary cannulation attempts have been shown to be an independent predictor of post-ERCP pancreatitis (PEP) when they are repeated more than 5 times or for 5 minutes or when the pancreatic duct is opacified or cannulated by using guidewire more than 1 time. In order to reduce complications, the 2016 ESGE guideline recommends a precise sequence of alternative cannulation techniques to the primary guidewire approach before exceeding the stated limits. However, there are no published data about the routinary application of this biliary cannulation algorithm.
The investigators hypothesised that the ESGE algorithm predicts an increased cannulation success. Nevertheless, it's unclear if this benefit is also associated with a decreased risk of complications, mainly post-procedural pancreatitis. conditions: Biliary Tract Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 800 type: ESTIMATED measure: Success of ERCP biliary cannulation rate measure: ERCP complication rates sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS OSpedale San Raffaele status: RECRUITING city: Milano zip: 20132 country: Italy name: Alberto Mariani, MD role: CONTACT lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06380530 id: SIMULA briefTitle: Advanced Surgical Simulation Processes in the Correction of Skeletal Defects and Deformities acronym: SIMULA overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2028-05 date: 2029-05 date: 2024-04-24 date: 2024-04-24 name: Istituto Ortopedico Rizzoli class: OTHER name: Ospedale Pediatrico Bambino Gesù name: Istituto Giannina Gaslini name: Galeazzi Orthopedic Institute name: Istituto Nazionale Tumori Regina Elena name: Policlinico San Matteo name: Istituto Clinico Humanitas briefSummary: Virtual Surgical Planning (VSP), Computer-Aided Surgical Simulation (CASS) for bone corrections, and the customization of implants and devices through 3D printing, known as Patient-Specific Instruments (PSI) and Graft-Specific Instruments (GSI), are assuming increasingly central roles in orthopedic clinical and surgical practice.
The aim of this study is to enhance the current process of simulating, planning, and designing surgical support tools within 3D Printing Point-of-Care (3D POC) facilities. To achieve this, it is imperative to expand case volumes and systematically organize, categorize, and standardize simulation and planning procedures. conditions: Musculoskeletal Deformity conditions: Musculoskeletal Abnormalities conditions: Musculoskeletal Disorder studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Deformity correction measure: Achieved skeletal corrections measure: Achieved skeletal corrections measure: Operating room times measure: Fluoroscopy times measure: Blood loss measure: Intra- and peri-operative complications measure: Suitability of PSIs measure: Suitability of GSIs measure: Suitability of bone graft measure: Clinical-functional outcome measure: Clinical-functional outcome measure: Cost analysis sex: ALL minimumAge: 2 Years maximumAge: 40 Years stdAges: CHILD stdAges: ADULT facility: IRCCS Istituto Ortopedico Rizzoli city: Bologna state: BO zip: 40136 country: Italy name: Grazia Chiara Menozzi role: CONTACT phone: 0516266 phoneExt: 484 email: graziachiara.menozzi@ior.it lat: 44.49381 lon: 11.33875 facility: Istituto Clinico Humanitas city: Rozzano state: MI country: Italy lat: 45.38193 lon: 9.1559 facility: Istituto Giannina Gaslini city: Genova country: Italy name: Giorgio Marrè Brunenghi, MD role: CONTACT email: giorgiomarre@gaslini.org lat: 44.40478 lon: 8.94438 facility: Galeazzi Orthopedic Institute city: Milano country: Italy name: Fabio Verdoni, MD role: CONTACT email: fabio.verdoni@grupposandonato.it lat: 45.46427 lon: 9.18951 facility: Policlinico San Matteo city: Pavia country: Italy name: Gianluigi Pasta, MD role: CONTACT lat: 45.19205 lon: 9.15917 facility: Istituto Nazionale Tumori Regina Elena city: Roma country: Italy name: Roberto Biagini, MD role: CONTACT email: roberto.biagini@ifo.it lat: 41.89193 lon: 12.51133 facility: Ospedale Pediatrico Bambino Gesù city: Roma country: Italy name: Pier Francesco Costici, MD role: CONTACT email: pierfrancesco.costici@opbg.net lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06380517 id: ATS23 id: 2UG1EY011751 type: NIH link: https://reporter.nih.gov/quickSearch/2UG1EY011751 briefTitle: Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age acronym: ATS23 overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-12-01 date: 2027-05-01 date: 2024-04-24 date: 2024-04-24 name: Jaeb Center for Health Research class: OTHER name: National Eye Institute (NEI) name: Pediatric Eye Disease Investigator Group briefSummary: In children 4 to 7 years of age, to determine if treatment with 1 hour per day 6 days per week of watching dichoptic movies/shows wearing the Luminopia headset is non-inferior to treatment with 2 hours of patching per day 7 days per week with respect to change in amblyopic eye distance VA from randomization to 26 weeks. conditions: Amblyopia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 238 type: ESTIMATED name: Luminopia name: Eye Patch measure: Change in amblyopic eye logMAR distance VA between randomization and 26 weeks sex: ALL minimumAge: 4 Years maximumAge: 7 Years stdAges: CHILD typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2024-04-01 uploadDate: 2024-04-18T09:58 filename: Prot_000.pdf size: 715474 typeAbbrev: SAP hasProtocol: False hasSap: True hasIcf: False label: Statistical Analysis Plan date: 2024-04-17 uploadDate: 2024-04-18T15:02 filename: SAP_001.pdf size: 4154847 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-04-17 uploadDate: 2024-04-18T09:59 filename: ICF_002.pdf size: 248300 hasResults: False
nctId: NCT06380491 id: REF.2338 id: UNAM-PAPIIT 32-IN216919 type: OTHER domain: Universidad Nacional Autonoma de Mexico (UNAM) briefTitle: Melatonin's Effect on Nighttime Blood Pressure and Sleep in OSA Patients (MEBP-OSA) acronym: MEBP-OSA overallStatus: RECRUITING date: 2023-06-22 date: 2024-11-22 date: 2025-01-22 date: 2024-04-24 date: 2024-04-25 name: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran class: OTHER name: Universidad Nacional Autonoma de Mexico name: Emory University briefSummary: The goal of this clinical trial is to learn if melatonin works to treat comorbid insomnia in adults with OSA and nocturnal non-dipping blood pressure pattern.
Does melatonin maintain sleep during night and recover the dipping blood pressure pattern? conditions: Obstructive Sleep Apnea of Adult studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients with a non-dipper pattern in blood pressure will randomly enter one of two options: 1) usual medical treatment; 2) treatment with melatonin plus usual care. primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: Melatonin 3 MG Oral Tablet measure: Melatonin at a dose of 3 mg before sleep time, after a period of 30 days changes the time awake after sleep onset (WASO), and recovers the dipper pattern of blood pressure sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: National Institute of Medical Sciences and Nutrition Salvador Zubirán (INCMNSZ) status: RECRUITING city: Mexico City country: Mexico lat: 19.42847 lon: -99.12766 hasResults: False
nctId: NCT06380478 id: CPRO-000012 briefTitle: Safety and Efficacy of the Bi-Aspheric Monofocal IOL overallStatus: RECRUITING date: 2024-03-05 date: 2024-12-05 date: 2024-12-25 date: 2024-04-24 date: 2024-04-24 name: ICARES Medicus, Inc. class: INDUSTRY name: AST Products, Inc. briefSummary: This is an observational, single-center, non-control, open-label post-marketing study. Patients implanted with an aspicio™ Monofocal Intraocular Lens will be scheduled for a follow-up visit at least 3 months after the surgery to undergo a routine basic ophthalmological examination. conditions: Cataract studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 30 type: ESTIMATED name: aspicio Monofocal IOL measure: CDVA measure: Defocus curve measure: UDVA measure: UIVA measure: CIVA measure: IOL glistening measure: PCO measure: Satisfaction questionnaire measure: AE sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chang Gung University Hospital status: RECRUITING city: Taoyuan state: Guishan District zip: 333 country: Taiwan name: Lisa Chen role: CONTACT email: lisa.phchen@gmail.com name: Yih-Shiou Hwang, MD role: PRINCIPAL_INVESTIGATOR lat: 24.95233 lon: 121.20193 hasResults: False
nctId: NCT06380465 id: 23-11-1838 briefTitle: The Effect of Anthocyanin Intake From Purple Sweet Potato in Cerebral Small Vessel Disease overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2025-04-30 date: 2025-04-30 date: 2024-04-24 date: 2024-04-24 name: Indonesia University class: OTHER name: Fakultas Kedokteran Universitas Indonesia name: Universitas Padjadjaran name: Institut Pertanian Bogor name: School of Science and technology, Kwansei Gakuin University briefSummary: Cerebral small vessel disease (CSVD) is a major cause of disability, cognitive impairment, and functional loss in the elderly. CSVD occurs due to damage to arterioles, capillaries, and venules in the brain parenchyma, and can cause clinical and neuroimaging symptoms. CSVD also accounts for up to 25% of all ischemic stroke cases, and making it the second leading cause of death in the world after ischemic heart disease.