hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06367322 id: EMP-PARA-20170-01 briefTitle: Statins and Post-ERCP Acute Pancreatitis (Stark Project) acronym: Stark overallStatus: COMPLETED date: 2017-01-10 date: 2018-07-31 date: 2018-09-30 date: 2024-04-16 date: 2024-04-16 name: Hospital General Universitario de Alicante class: OTHER name: European Pancreatic Club (EPC), Pancreas 2000 Educational Program briefSummary: Post-endoscopic retrograde cholangiopancrepatography (ERCP) acute pancreatitis (PEAP) is a frequent complication of this endoscopic procedure. Chronic statin intake has been linked to lower incidence and severity of acute pancreatitis (AP). Periprocedural rectal administration of non-steroidal anti-inflammatory drugs is protective against PEP, but the role of chronic acetylsalicylic acid (ASA) treatment is unclear. The aim of the study is to investigate whether statins and chronic ASA intake are associated with lower risk of PEAP. conditions: Post-ERCP Acute Pancreatitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1016 type: ACTUAL name: Statin measure: To assess the incidence and relative risk of PEAP according to statin use. measure: To assess the effect of chronic use of other drugs on the incidence and relative risk of PEAP. measure: To assess the effect of other factors (demographic and endoscopic) on the incidence and relative risk of PEAP and severity of PEAP (severity according to the Revised Atlanta Classification). sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Alicante city: Alicante zip: 03010 country: Spain lat: 38.34517 lon: -0.48149 facility: Hospital General Universitario de Alicante city: Alicante zip: 03010 country: Spain lat: 38.34517 lon: -0.48149 hasResults: False
nctId: NCT06367309 id: 2023 - 02357 briefTitle: ExtrAperitoneaL Plasty vs Intraperitoneal oNlay mEsh in Ventral Hernia Repair acronym: ALPINE overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2025-12-31 date: 2030-12-31 date: 2024-04-16 date: 2024-04-16 name: University Hospital, Basel, Switzerland class: OTHER name: St. Clara Hospital, Basel, Switzerland name: Innklinikum Altötting, Germany briefSummary: This study investigates on the effect of two different operative techniques to treat abdominal wall hernias.
Either be operated using the eTEP or the IPOM technique. Be followed up either in person or via email / phone call at day 1, day 7, day 14, 6 weeks, 6 months, 1, 3 and 5 years after the surgery to asses the above-stated main and some more outcomes. conditions: Ventral Hernia conditions: Abdominal Wall Defect studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: The trial participants and the assessors (trained investigators not involved in the operative procedures) of the primary outcome are blinded regarding the performed procedure during the first seven days after the procedure to reduce bias. The blinding is guaranteed by not sharing the detailed operation report with anyone involved in the aftercare of the patient or in the assessment of study outcomes. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 138 type: ESTIMATED name: Extended totally extraperitoneal repair name: Intraperitoneal onlay mesh measure: primary outcome: pain numeric rating scale (NRS) measure: pain outcome using the Patient-Reported Outcome Measurement Information System (PROMIS) Pain Intensity Short Form 3a measure: pain mid-term measure: recurrence and reoperation measure: LOS measure: Functional recovery measure: Adverse events measure: Quality of life (SF 12) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: St. Clara Hospital city: Basel state: Basel-Stadt zip: 4058 country: Switzerland name: Fiorenzo Angehrn, MD role: CONTACT email: fiorenzo.angehrn@clarunis.ch lat: 47.55839 lon: 7.57327 hasResults: False
nctId: NCT06367296 id: RETOPO2024 briefTitle: Resistance Exercise Training in the Older Population With Obesity acronym: RETOPO overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-01-28 date: 2025-06-01 date: 2024-04-16 date: 2024-04-16 name: Universidad de La Frontera class: OTHER briefSummary: Background:
Aging leads to an alteration in the immune response, characterized by a chronic inflammatory state, and a progressive decrease in muscle quantity and quality, a situation that increases in women and in the presence of obesity. With respect to muscle quality, intramuscular infiltration of adipose tissue has been considered a relevant parameter, involved in the relationship between aging-obesity-inflammation. As a therapeutic strategy, physical training with resistance exercises (or also known as strength training) has been shown to be effective in increasing skeletal muscle mass in this age group. However, its role on muscle quality in normal-weight versus obese older women has not been fully addressed.
nctId: NCT06367283 id: 2023-509181-38-00 briefTitle: Metformin Treatment of Patients With Hand Osteoarthritis acronym: METRO overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2026-04 date: 2024-04-16 date: 2024-04-16 name: Marius Henriksen class: OTHER briefSummary: To compare metformin (2 g daily), or maximum tolerated dose, for 16 weeks with placebo as a treatment of hand osteoarthritis symptoms. conditions: Hand Osteoarthritis studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 150 type: ESTIMATED name: Metformin name: Placebo measure: Finger pain measure: Function measure: Thumb base pain measure: Hand pain measure: Physician tender joint count measure: Patient global assessment measure: Quality of life assessed by the European Quality of life - 5 dimensions (EQ-5D) scale measure: Hand strength measure: Number of treatment responders measure: Stiffness of both hands measure: Composite of pain, function and stiffness measure: Physical function measure: Physician global assessment measure: Swollen joint count measure: Fatigue measure: Sleep quality measure: Absence or presence of inflammation of target hand measure: Change in use of analgesics measure: Inflammatory biomarker measure: Metabolic outcomes measure: Metabolic outcomes measure: Vitamin K measure: Proteomics sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Parker Institute, Bispebjerg and Frederiksberg hospital city: Copenhagen state: Frederiksberg zip: 2000 country: Denmark name: Kasper Staberg Madsen, MD role: CONTACT phone: +4538164162 email: kasperstabergmadsen@regionh.dk lat: 55.67594 lon: 12.56553 hasResults: False
nctId: NCT06367270 id: UW 23-361 briefTitle: The Application of Pressured Intraperitoneal Aerosol Chemotherapy (PIPAC) for Peritoneal Surface Malignancies acronym: PIPAC overallStatus: RECRUITING date: 2023-09-01 date: 2026-08-31 date: 2027-08-31 date: 2024-04-16 date: 2024-04-16 name: The University of Hong Kong class: OTHER briefSummary: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel minimally invasive drug delivery system for patients with peritoneal metastases (PM). It has been considered as a safe and feasible palliative treatment alternative proven by previous phase I studies. Currently available evidence on feasibility, efficacy and tolerability in Asian populations is limited. In this open-label, single-arm, monocentric clinical trial, investigators aim to evaluate the therapeutic efficacy and complications of PIPAC with oxaliplatin as an alternative on patients of unresectable colorectal cancer with PM and doxorubicin and cisplatin on patients of unresectable gastric and pancreatic cancers with PM. Alternative regimen can be considered multidisciplinary tumour board meeting. Patients will be recruited according to the inclusion criteria and treated for 3 cycles of PIPAC and concurrent systemic chemotherapy. The goal was to repeat PIPAC every 6-8 weeks for at least three procedures, and the delay of the systemic chemotherapy is 2 weeks before and after each PIPAC procedure. If PM was considered to become resectable during PIPAC, patients were discussed at the multidisciplinary tumour board for curative intent cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). The primary outcome is the clinical benefit rate (CBR), measured by an independent radiologist according to Response Evaluation Criteria In Solid Tumors (RECIST) and Peritoneal Cancer Index (PCI) assessed by laparoscopy and histopathological tumour response evaluated by pathologists blinded to clinical outcomes. Key secondary outcomes include the major and minor treatment-related adverse events according to the Common Terminology Criteria for Adverse Events (CTACE) up to 4 weeks after the treatment, Cytological tumour response of peritoneal lavage or ascites, treatment-related characteristics, hospital stay, progression-free survival, overall survival and readmission rate. The proposed study duration is 3 years from the start date and the estimated sample size is 51 according to centre capacity. conditions: Peritoneal Metastases studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Pressured Intraperitoneal Aerosol Chemotherapy measure: Clinical benefit rate (CBR) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Queen Mary Hospital status: RECRUITING city: Hong Kong country: Hong Kong name: Ian WONG, Dr. role: CONTACT phone: +852 2255 4774 email: iyhwong@hku.hk name: Ian WONG, Dr. role: PRINCIPAL_INVESTIGATOR lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06367257 id: Emento App briefTitle: App-based Recording and Optimization of the Nutritional Status in Patients With Head and Neck Tumors During and After Radio(Chemo)Therapy overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-04-30 date: 2026-06-30 date: 2024-04-16 date: 2024-04-16 name: University of Erlangen-Nürnberg Medical School class: OTHER briefSummary: Patients with head and neck cancer requiring definitive or adjuvant radio(chemo)therapy can take part in the study. The aim is to record the nutritional status and diet of the patients during the trial and regularly at a period of 8 weeks after irradiation and to reduce the rate of weight loss and malnutrition. conditions: Squamous Cell Carcinoma of Head and Neck studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: PARTICIPANT count: 148 type: ESTIMATED name: App Usage name: Standard of Care measure: Change in rates of weight loss with additional app-based Patient Care measure: Frequency of deteriorations in health status subjectively reported by patients and recorded via the app. measure: Frequency of additional app-triggered contacts of the clinic with the patients measure: Frequency of critical health conditions (physician-verified) detected earlier by the app. measure: Change in quality of life measured per questionnaires measure: Change of incidence of malnutrition and sarcopenia before, during and after radio(chemo)therapy. measure: Change of course of malnutrition and sarcopenia before, during and after radio(chemo)therapy. measure: Rate of therapy interruptions/discontinuations measure: Overall survival measure: Disease-free/progression-free survival measure: Change of Loco-regional tumor control sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Universitätsklinikum Erlangen, Strahlenklinik city: Erlangen state: Bavaria zip: 91054 country: Germany name: Marlen Haderlein, PD role: CONTACT phone: +49913185 phoneExt: 33968 email: marlen.haderlein@uk-erlangen.de name: Studiensekretariat role: CONTACT phone: +49913185 phoneExt: 33968 email: studiensekretariat.ST@uk-erlangen.de name: Allison Lamrani role: PRINCIPAL_INVESTIGATOR name: Charlotte Schmitter, Dr. role: PRINCIPAL_INVESTIGATOR lat: 49.59099 lon: 11.00783 hasResults: False
nctId: NCT06367231 id: Pro00134554 briefTitle: SCGs as a Proxy for Determining the Cognitive Status of Older Adults overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-07-01 date: 2024-04-16 date: 2024-04-16 name: University of Alberta class: OTHER briefSummary: Detecting memory problems early is crucial for treating conditions like Mild Cognitive Impairment (MCI), which often leads to dementia. Currently, doctors use tests in clinics to check for these issues. However, there's a growing need for better methods to monitor our cognitive skills over time. Computer games emerge as a cost-effective solution for assessing the brain functions of older adults.
In our study, we are investigating the potential of computer games to reflect the cognitive skills of older adults. We developed the VibrantMinds platform, featuring five games: Whack-a-Mole, Bejeweled, Mahjong Solitaire, Word Search, and Memory Game. We have evaluated these games for ease of use, enjoyment, and their impact on brain functions. Now, our goal is to determine whether these games can offer valuable insights into the cognitive skills of older adults.
We are collecting demographic data, game-playing data, and cognitive test results. Our analysis will determine the correlation between game data, cognitive test outcomes, and demographic information. Additionally, we will assess both the perceived and observed engagement of older adults as they play the games. conditions: Mild Cognitive Impairment conditions: Dementia conditions: Alzheimer Disease conditions: Healthy Aging conditions: Cognitive Decline studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 58 type: ESTIMATED name: VibrantMinds measure: Cognition - Global measure: Cognition - Global measure: Cognition - Executive Function measure: Game Performance measure: Game Engagement sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT hasResults: False
nctId: NCT06367218 id: S058 briefTitle: Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-07-01 date: 2026-08-01 date: 2024-04-16 date: 2024-04-16 name: Tongji Hospital class: OTHER briefSummary: Non-tracheal intubated combined anesthesia with preserved spontaneous breathing significantly enhances the quality and speed of recovery post-VATS for patients undergoing lung nodule surgery. The "opioid-sparing strategy," which substitutes ketamine for opioids during surgery, not only provides effective analgesia but also protects perioperative lung function and reasonably prevents the occurrence of opioid-related adverse reactions; it also reduces medical costs and shortens the average hospital stay. However, the degree of benefit to patients lacks high-level clinical evidence. This study aims to comprehensively assess the effect of opioid-free combined anesthesia with preserved spontaneous breathing for VATS lung nodule surgery on postoperative rapid recovery from multiple aspects including postoperative lung function and pulmonary complications, pain, gastrointestinal function, nausea/vomiting, cognitive function, and depression/anxiety, intending to expand the dataset and application prospects in this field, and increase feasibility experience. conditions: Video-assisted Thoracoscopic Lung Surgery；Anesthesia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 480 type: ESTIMATED name: opioid based strategy name: opioid-free strategy name: Laryngeal mask airway; Preserved spontaneous breathing name: Double lumen tracheal tube; Mechanical ventilation measure: Lung function 30 days after surgery measure: Intraoperative respiratory parameters measure: Intraoperative respiratory parameters measure: Intraoperative respiratory parameters measure: Intraoperative respiratory parameters measure: Intraoperative respiratory parameters measure: Perioperative stage indicators measure: Perioperative stage indicators measure: Postoperative pain measure: Postoperative Lung function measure: Postoperative Lung function measure: Postoperative pulmonary complications measure: Postoperative gastrointestinal function measure: Postoperative depression/anxiety measure: Postoperative cognitive function measure: Time of first exercise after surgery measure: The 6-minute walking experiment measure: Length of stay measure: Quality of life measurement measure: Intraoperative circulation parameters measure: Intraoperative circulation parameters measure: Intraoperative circulation parameters measure: Intraoperative circulation parameters measure: Intraoperative circulation parameters measure: Intraoperative circulation parameters sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06367205 id: LY2023-135-A briefTitle: Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations overallStatus: RECRUITING date: 2024-03-01 date: 2026-04-30 date: 2026-06-30 date: 2024-04-16 date: 2024-04-16 name: RenJi Hospital class: OTHER briefSummary: Delayed graft function (DGF), delineated by the necessity for dialytic intervention within the initial week post-transplantation, afflicts approximately 20%-50% of recipients. The primary objective of this study is to investigate the potential efficacy of norepinephrine infusion in conjunction with goal-directed fluid therapy (GDFT) in mitigating the occurrence of DGF among individuals undergoing kidney transplantations. The findings of this investigation have the potential to advance the field of perioperative care in kidney transplantations by providing insights into optimized management strategies. conditions: Delayed Graft Function conditions: End Stage Renal Disease conditions: Kidney Transplantation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 380 type: ESTIMATED name: Goal-Directed Fluid Therapy (GDFT) name: Regular Fluid Therapy measure: The incidence of delayed graft function (DGF) measure: The area under the curve of serum creatinine levels from postoperative day 1 to 7 measure: Duration of DGF measure: Number of dialysis sessions during postoperative hospitalization measure: Total urine output on the second postoperative day measure: Duration of intensive care unit (ICU) stay measure: Length of hospitalization measure: Incidence of readmission within 30 days post-discharge measure: The incidence of acute rejection during hospitalization measure: The survival rates of transplanted kidneys at the one-year postoperative mark measure: The survival rates of transplanted patients at the one-year postoperative mark measure: The occurrence of adverse events (AEs) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: the First Affiliated Hospital of Zhengzhou University status: NOT_YET_RECRUITING city: Zhengzhou state: Henan zip: 450052 country: China name: Jianjun Yang, Dr. role: CONTACT lat: 34.75778 lon: 113.64861 facility: General Hospital of Northern Theatre Command status: NOT_YET_RECRUITING city: Shenyang state: Liaoning zip: 110016 country: China name: Yugang Diao, Dr. role: CONTACT lat: 41.79222 lon: 123.43278 facility: Renji Hospital status: RECRUITING city: Shanghai state: Shanghai zip: 200127 country: China name: Muyan Shi, B.S. role: CONTACT phone: +862168383702 email: jsqdsmy@163.com lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06367192 id: SKITS2 id: K23HL166697 type: NIH link: https://reporter.nih.gov/quickSearch/K23HL166697 briefTitle: School Readiness Intervention for Preschool Children With Sickle Cell Disease overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-10 date: 2028-10 date: 2024-04-16 date: 2024-04-16 name: St. Jude Children's Research Hospital class: OTHER name: National Heart, Lung, and Blood Institute (NHLBI) briefSummary: The study participant is being asked to take part in this clinical trial, a type of research study, because the participant is a young child with sickle cell disease or the caregiver of a child with sickle cell disease. This study is being done to test a school readiness program for children with sickle cell disease (ages 4-6 years old).
Examine implementation factors (i.e., barriers and facilitators) during post-intervention. conditions: Sickle Cell Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 36 type: ESTIMATED name: The adapted Kids in Transition to School Intervention name: Standard school resources measure: Feasibility of Intervention Measure measure: Acceptability of Intervention Measure measure: Bracken School Readiness Assessment - 3rd Edition measure: Woodcock Johnson Tests of Achievement - Fourth Edition measure: NIH Toolbox Flanker Test measure: Head-Toes-Knees-Shoulders Revised measure: Behavior Rating Inventory of Executive Functioning Preschool or Child measure: The Parenting Scale sex: ALL minimumAge: 4 Years maximumAge: 6 Years stdAges: CHILD facility: St. Jude Children's Research Hospital city: Memphis state: Tennessee zip: 38105 country: United States name: ANDREW HEITZER, PhD role: CONTACT name: ANDREW HEITZER, PhD role: PRINCIPAL_INVESTIGATOR lat: 35.14953 lon: -90.04898 hasResults: False
nctId: NCT06367179 id: 202401039RINC briefTitle: Virtual Reality and AI Wound-detecting System overallStatus: RECRUITING date: 2024-03-22 date: 2025-02-04 date: 2025-02-04 date: 2024-04-16 date: 2024-04-16 name: National Taiwan University Hospital class: OTHER briefSummary: This study is an experimental study. The main caregivers of pressure injury patients in the plastics surgery ward and general medicine ward of the hospital in Taipei City who are over 20 years old, have good communication skills in Chinese and Taiwanese or who can read Chinese are the research objects. During the study process, pre-tests will be given to the accepted subjects, which are the correctness evaluation scale of caregiver's pressure injury wound dressing change and caregiver self-efficacy scale, and then the accepted subjects will be divided into experimental group and control group. The experimental group will receive interventions of virtual reality and artificial intelligence wound detecting system, while the control group maintained the traditional pressure injury health education with oral introduction and health education leaflet. After the intervention measures are given, a post-test (same as the pre-test content) will be conducted within two days. Finally, analyze the effectiveness of the intervention of virtual reality pressure injury education video and artificial intelligence wound detecting system on caregivers of pressure injury improve wound care correctness and increase self-efficacy. conditions: Pressure Injury studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 92 type: ESTIMATED name: Virtual reality and AI use name: Health education leaflet measure: Accurate dressing change rate of pressure injury measure: Pressure injury dressing change of self-efficacy sex: ALL minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Taiwan University Hospital status: RECRUITING city: Taipei zip: 100225 country: Taiwan name: Cian Huei Wang role: CONTACT phone: (02)23123456 phoneExt: 263502 email: chw0710@ntuh.gov.tw lat: 25.04776 lon: 121.53185 hasResults: False