hackint0sh/New-Dataset huggingface dataset:
Intervention: Participants at intervention clinics (n=4) will be offered free POC-cHbA1c testing on-site, immediately informed of test results and DM risk, and scheduled for confirmatory oral glucose tolerance test (OGTT) if screened positive (i.e. HbA1c≥5.6%). Participants at control clinics will be offered free vHbA1c testing scheduled on a separate day, informed of test results and DM risk via phone, and scheduled for confirmatory OGTT if screened positive.
Expected results: A greater proportion of T2DM patients will be detected by POC-cHbA1c than vHbA1c due to a higher screening test uptake rate among the studied population. conditions: Diabetes Mellitus conditions: Pre-diabetes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: NONE count: 776 type: ESTIMATED name: POC-cHbA1c testing measure: Proportional difference in detection of T2DM measure: Uptake rate measure: Proportion of high-risk HbA1c concentration measure: Difference in uptake rate of OGTT measure: Number-needed-to-screen to detect one more T2DM case measure: Proportion of patients who refuse to join the study sex: ALL minimumAge: 45 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Aberdeen Jockey Club General Out-Patient Clinic status: RECRUITING city: Hong Kong country: Hong Kong name: Linda Chan role: CONTACT phone: 25185657 email: lmjchan@hku.hk lat: 22.27832 lon: 114.17469 facility: Kwun Tong Community Health Centre status: RECRUITING city: Hong Kong country: Hong Kong name: Linda Chan role: CONTACT phone: 25185657 email: lmjchan@hku.hk lat: 22.27832 lon: 114.17469 facility: Lek Yuen General Out-Patient Clinic status: RECRUITING city: Hong Kong country: Hong Kong name: Linda Chan role: CONTACT phone: 25185657 email: lmjchan@hku.hk lat: 22.27832 lon: 114.17469 facility: Li Po Chun General Out-Patient Clinic status: RECRUITING city: Hong Kong country: Hong Kong name: Linda Chan role: CONTACT phone: 25185657 email: lmjchan@hku.hk lat: 22.27832 lon: 114.17469 facility: Ma On Shan Family Medicine Centre status: RECRUITING city: Hong Kong country: Hong Kong name: Linda Chan role: CONTACT phone: 25185657 email: lmjchan@hku.hk lat: 22.27832 lon: 114.17469 facility: Sai Ying Pun Jockey Club General Out-patient Clinic status: RECRUITING city: Hong Kong country: Hong Kong name: Linda Chan role: CONTACT phone: 25185657 email: lmjchan@hku.hk lat: 22.27832 lon: 114.17469 facility: Tseung Kwan O (Po Ning Road) General Out-patient Clinic status: RECRUITING city: Hong Kong country: Hong Kong name: Linda Chan role: CONTACT phone: 25185657 email: lmjchan@hku.hk lat: 22.27832 lon: 114.17469 facility: Yau Ma Tei Jockey Club Specialist Clinic status: RECRUITING city: Hong Kong country: Hong Kong name: Linda Chan role: CONTACT phone: 25185657 email: lmjchan@hku.hk lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06382350 id: KHL-002-2024 briefTitle: Glycemic Excursions in Patients With Type 1 Diabetes Mellitus Using Closed-loop Systems acronym: SAFEDRIVE overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-09 date: 2026-05 date: 2024-04-24 date: 2024-04-24 name: University Hospital, Motol class: OTHER briefSummary: The study aims to compare glycemic excursions during several life situations (such as periods of driving, periods of night sleep, periods of occupation, periods of physical activity, and periods of stress) in patients with type 1 diabetes treated with closed-loop system and multiple daily insulin dose therapy conditions: Type 1 Diabetes Mellitus conditions: Type 1 Diabetes Mellitus With Hypoglycemia conditions: Drive studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 120 type: ESTIMATED name: MiniMed 780 G measure: The frequency of hypoglycemia (<3.9 mmol/l) during the driving periods measure: Period of time spent in a range between 3.9 and 4.5 mmol/l (a risky period) during driving. measure: Specific CGM analysis in relation to recorded the daily activities sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06382337 id: A03010240S briefTitle: Immediate Dental Implants in The Upper Anterior Region overallStatus: NOT_YET_RECRUITING date: 2024-04-21 date: 2025-03 date: 2025-04 date: 2024-04-24 date: 2024-04-24 name: Mansoura University class: OTHER briefSummary: The aim of the study will be to evaluate maxillary anterior teeth replacement with immediate dental implant utilizing vestibular socket therapy versus ice cream cone technique both clinically and radiographically. conditions: Teeth Loss conditions: Alveolar Bone Resorption studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 16 type: ESTIMATED name: Group A : ice cream cone technique name: Group B : the vestibular socket therapy measure: Bone changes measure: soft tissue changes sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Faculty of Dentistry Mansoura University city: Mansoura zip: 7650001 country: Egypt role: CONTACT phone: 050 2248512 email: dentfac@mans.edu.eg name: Mohamed Fa Shoeib, demonstrator role: PRINCIPAL_INVESTIGATOR lat: 31.03637 lon: 31.38069 hasResults: False
nctId: NCT06382324 id: 202301280B0 briefTitle: The Psychological Impact of Mindfulness Intervention to Anterior Cruciate Ligament Reconstruction overallStatus: RECRUITING date: 2024-04 date: 2025-06 date: 2025-12 date: 2024-04-24 date: 2024-04-24 name: Chang Gung Memorial Hospital class: OTHER briefSummary: Anterior cruciate ligament (ACL) reconstruction surgery is a common procedure performed by orthopedic surgeons. Postoperatively, patients often experience pain, muscle tension, and concerns about their ability to return to sports. These factors influence the recovery and return to sports capabilities of ACL patients. According to research, only 64% of patients are able to recover to their pre-injury level after surgery, and the success rate for returning to competitive sports is only 56%. Psychological factors during the recovery process may explain this disparity. ACL injury is associated with anxiety, pain reaction, and emotional disorders, with fear of re-injury being the most common obstacle to returning to sports, accounting for 19%. A study by Lentz et al. (2015) also found no significant differences in pain assessments between individuals who were afraid of re-injury and those who were able to return to sports at six months and one year after surgery. This suggests that fear of pain may limit activity and increase the risk of unsuccessful return to sports.
Mindfulness intervention is a psychological approach that involves non-judgmental awareness and focus on moment to moment. Mindfulness practice is known to reduce stress in athletes, promote recovery, enhance athletic performance, and improve sleep quality. Good sleep quality contributes to emotional stability and physical recovery. Even short daytime naps can be beneficial for athletes. A review of 37 studies of moderate quality found that daytime napping can improve physical and cognitive performance, psychological state, and nighttime sleep.
* Control group: listening to light music for 40 minutes. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The outcome assessor of polysomnography did not know the data belongs which group whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: mindfulness practice of body scan name: listening to light music measure: Electroencephalogram (EEG) measure: Electrooculography (EOG) measure: Electromyography (EMG) measure: ECG (Electrocardiography) measure: Nasal/Oral airflow measure: Thermistor measure: Chest and abdominal belt measure: Oximetry measure: Snoring measure: Karolinska Sleepiness Scale (KSS) measure: Five Facet Mindfulness Questionnaire (FFMQ) measure: State-Trait Anxiety Inventory (STAIS) measure: Anterior Cruciate Ligament Return to Sport After Injury Scale (ACL-RSI) (Short Version) sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: ChangGungMH status: RECRUITING city: Keelung zip: 204004 country: Taiwan name: Jian-Hong Chen role: CONTACT phone: 096-130-7506 email: psydr.jc@gmail.com name: Chang Gung Memorial Hospital role: PRINCIPAL_INVESTIGATOR lat: 25.12825 lon: 121.7419 hasResults: False
nctId: NCT06382298 id: PROJECT00009332 briefTitle: Cottonseed Oil Versus Matched PUFA Effects overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2026-12 date: 2028-05 date: 2024-04-24 date: 2024-04-26 name: University of Georgia class: OTHER name: United States Department of Agriculture (USDA) briefSummary: Cardiovascular disease risk factors, including higher BMIs and poor cholesterol profiles, are on the rise and contribute to the United States' growing disease burden. Cottonseed oil (CSO) is found readily in the food supply, and the investigator's previous studies have demonstrated that incorporating CSO into the diet is sufficient to improve fasting cholesterol profile and improve postprandial lipid and/or glycemic responses in both healthy, and at-risk populations. This study aims to compare CSO to a fatty acid composition-matched diet, on changes in fasting and postprandial lipid metabolism and markers of chronic disease risk.
Researchers will compare CSO vs. PUFA and control groups (receiving a mixture of oils) to see if CSO is unique in imparting health benefits when compared with similar matched oil diets. conditions: Dyslipidemia conditions: Overweight and Obesity conditions: Nutrition, Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Three groups of 28-day parallel feeding trials with two groups receiving 20% of energy needs from CSO, or matched PUFA diet, and one group serving as control receiving 20% of energy needs as a mixture of oils that match the fatty acid profile of the average American intake. primaryPurpose: PREVENTION masking: DOUBLE maskingDescription: Participants are blinded to oil intervention group. Investigator blinded to participant's oil intervention group. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 90 type: ESTIMATED name: COTTONSEED OIL name: MATCHED PUFA DIET name: CONTROL measure: Change in fasting serum lipoprotein and cholesterol concentrations measure: Change in fasting serum lipoprotein particle numbers measure: Change in fasting and postprandial plasma triglyceride concentrations measure: Change in fasting and postprandial plasma non-esterified fatty acid (NEFA) concentrations measure: Change in fasting and postprandial plasma glucose concentrations measure: Change in fasting and postprandial plasma insulin concentrations measure: Change in fasting and postprandial plasma appetite control hormones concentrations measure: Change in fasting and postprandial subjective feelings related to appetite measure: Change in fasting and postprandial plasma Malondialdehyde (MDA) measure: Change in fasting and postprandial plasma total antioxidant capacity measure: Change in fasting inflammatory cytokine concentrations measure: Change in fasting plasma markers of coagulation potential measure: Change in fasting and postprandial plasma angiopoietin-like (ANGPTL) proteins measure: Change in fasting insulin resistance metrics measure: Desaturation index measure: Change in fasting serum hepatic enzymes measure: Change in fasting serum hepatic proteins measure: Change in fasting serum bilirubin measure: Change in additional fasting plasma inflammatory cytokine concentrations measure: Change in additional fasting plasma markers of coagulation potential measure: Change in acute dietary intake measure: Change in blood pressure measure: Change in body weight measure: Change in body composition measure: Change in diet composition measure: Change in fasting tocopherol concentrations measure: Change in anthropometric circumferences measure: Change in resting metabolic rate measure: Change in Perceived Stress measure: Change in anxiety measure: Change in self reported physical activity levels measure: Change in Body Mass Index (BMI) sex: ALL minimumAge: 25 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Georgia city: Athens state: Georgia zip: 30602 country: United States lat: 33.96095 lon: -83.37794 hasResults: False
nctId: NCT06382285 id: 0206-22-ASF briefTitle: The Effect of a Prolonged Peripheral Nerve Block on the Level of Pain After a Knee Replacement overallStatus: NOT_YET_RECRUITING date: 2024-10-30 date: 2025-10-30 date: 2026-01-31 date: 2024-04-24 date: 2024-04-24 name: Assaf-Harofeh Medical Center class: OTHER_GOV briefSummary: The aim of this study is to examine the effect of a prolonged peripheral nerve block (utilizing continuous adductor canal block) on the level of pain after a knee replacement surgery conditions: Knee Replacement Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study will include 50 patients who underwent a knee replacement surgery, who will be randomized to 2 groups. 6 hours after surgery the two groups will be connected to a prolonged block pump. One group will receive the peripheral block ropivacaine 0.2% according to the protocol of 8-10 cc per hour up to 24 hours after surgery. The second group will receive saline according to the same protocol primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 50 type: ESTIMATED name: Continues peripheral block measure: Pain level measure: Analgesic use measure: Physiotherapy sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06382259 id: H24-Acute-Movement-Breaks briefTitle: The Acute Effect of Movement Breaks on Glycemic Responses in Individuals With Type 2 Diabetes overallStatus: NOT_YET_RECRUITING date: 2024-04-19 date: 2025-07-15 date: 2025-07-15 date: 2024-04-24 date: 2024-04-24 name: University of British Columbia class: OTHER name: McMaster University briefSummary: To conduct a randomized crossover trial to determine the acute impact of low-intensity movement breaks on glycemic control in physically inactive individuals living with type 2 diabetes using continuous glucose monitoring. conditions: Type 2 Diabetes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: Movement breaks measure: Mean 24-h glucose concentration determined using continuous glucose monitoring assessed using continuous glucose monitoring measure: Time in range determined using continuous glucose monitoring measure: Time above range determined using continuous glucose monitoring measure: Time below range determined using continuous glucose monitoring measure: Glycemic variability determined using continuous glucose monitoring measure: Two-hour glucose area under the curve following standardized breakfast, lunch and dinner meals sex: ALL minimumAge: 30 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06382246 id: H24-Acute-ExSnacks briefTitle: The Acute Effect of "Exercise Snacks" on Glycemic Responses in Individuals With Type 2 Diabetes overallStatus: NOT_YET_RECRUITING date: 2024-04-19 date: 2025-07-15 date: 2025-07-15 date: 2024-04-24 date: 2024-04-24 name: University of British Columbia class: OTHER name: McMaster University briefSummary: To conduct a randomized crossover trial to determine the acute impact of exercise snacks on glycemic control in physically inactive individuals living with type 2 diabetes using continuous glucose monitoring. conditions: Type 2 Diabetes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Randomized controlled crossover design primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: Exercise snacks measure: Mean 24-h glucose concentration determined using continuous glucose monitoring assessed using continuous glucose monitoring measure: Time in range determined using continuous glucose monitoring measure: Time above range determined using continuous glucose monitoring measure: Time below range determined using continuous glucose monitoring measure: Glycemic variability determined using continuous glucose monitoring measure: Two-hour glucose area under the curve following standardized breakfast, lunch and dinner meals sex: ALL minimumAge: 30 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06382233 id: PRO-FUTURE project briefTitle: The PRO-FUTURE Project acronym: PRO-FUTURE overallStatus: RECRUITING date: 2024-01-30 date: 2026-01-30 date: 2028-01-30 date: 2024-04-24 date: 2024-04-24 name: University of Campania "Luigi Vanvitelli" class: OTHER name: University of Milan name: A.O.R.N. Santobono-Pausilipon name: University of Modena and Reggio Emilia name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico briefSummary: The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are:
* Do babies with unilateral UPJO have a whole blood gene expression profiling (WBGEP) allowing an accurate unilateral UPJO diagnosis? conditions: Ureteropelvic Junction Obstruction conditions: Chronic Kidney Diseases studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 85 type: ESTIMATED name: Identification of Diagnostic Biomarkers measure: Urine Biomarkers measure: Blood Biomarkers sex: ALL minimumAge: 1 Day maximumAge: 5 Years stdAges: CHILD facility: Univeristà degli Studi della Campania Luigi Vanvitelli status: RECRUITING city: Naples state: Campania zip: 80138 country: Italy name: Pierluigi Marzuillo role: CONTACT name: Pierluigi Marzuillo role: PRINCIPAL_INVESTIGATOR name: Paolo Montaldo role: PRINCIPAL_INVESTIGATOR name: Carmine Noviello role: PRINCIPAL_INVESTIGATOR name: Alfonso Papparella role: SUB_INVESTIGATOR name: Stefano Guarino role: SUB_INVESTIGATOR name: Anna Di Sessa role: SUB_INVESTIGATOR name: Grazia Cirillo role: SUB_INVESTIGATOR name: Giusy Capasso role: SUB_INVESTIGATOR lat: 40.85216 lon: 14.26811 facility: Department of Clinical Sciences and Community Health, University of Milano status: ACTIVE_NOT_RECRUITING city: Milan country: Italy lat: 45.46427 lon: 9.18951 facility: Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico status: RECRUITING city: Milan country: Italy name: Giovanni Montini role: CONTACT name: Giovanni Montini role: PRINCIPAL_INVESTIGATOR name: Alfredo Berrettini role: PRINCIPAL_INVESTIGATOR name: Michele Gnech role: SUB_INVESTIGATOR lat: 45.46427 lon: 9.18951 facility: Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia status: RECRUITING city: Modena country: Italy name: Giovanni Grandi role: CONTACT name: Giovanni Grandi role: PRINCIPAL_INVESTIGATOR name: Stefano Puliatti role: SUB_INVESTIGATOR lat: 44.64783 lon: 10.92539 facility: AORN Santobono-Pausilipon status: RECRUITING city: Naples country: Italy name: Giovanni Di Iorio role: CONTACT name: Giovanni Di Iorio role: PRINCIPAL_INVESTIGATOR name: Agnese Roberti role: SUB_INVESTIGATOR lat: 40.85216 lon: 14.26811 hasResults: False
nctId: NCT06382220 id: R550 briefTitle: Low Dose Bupivacaine Versus Prilocaine Regarding Hemodynamic Stability and Safety in Geriatrics overallStatus: RECRUITING date: 2024-04-23 date: 2024-07-25 date: 2024-08-15 date: 2024-04-24 date: 2024-04-25 name: Fayoum University Hospital class: OTHER briefSummary: Orthopedic interventions under spinal anesthesia is considered a common practice in elderly patients undergo surgery, and may be associated with lower risks of death, delirium,and major medical complications .
Spinal anesthesia can cause disastrous hemodynamical changes in the form of hypotension and bradycardia in elderly patients due to limited physiological reserve and presence of systemic illness . The degree of hypotension is proportional to the extent of sympathetic blockade. thus unilateral Spinal anesthesia described by Tanasichuk et AL. was used aiming to minimize these hymodynamical changes compared to bilateral block by restricting the extent of sympathetic blockade.
Bupivacaine has been used in spinal anaesthesia in orthodecic surgeries . It provides a short motor block onset time with a long motor block duration . If bupivacaine is used, the main disadvantage is the significant inter-individual variability with clinically significant differences in onset time, dermatomal spread and motor block duration . Prilocaine is a local anaesthetic agent that belongs to the same family as bupivacaine. In the last decade and with the development of day surgery, prilocaine 2% has become more commonly used for orthopaedic surgical procedures . Prilocaine induces a shorter motor block with less urinary retention, which better facilitates enhanced recovery after surgery . Usually, doses administered in spinal anaesthesia vary from 20 to 80 mg . Given the intermediate motor block duration,
To compare between Unilateral low dose spinal anesthesia using bupivacaine versus prilocaine regarding hemodynamical stability and safety in below knee orthopedic surgeries in elderly people. conditions: Recruitment studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Bupivacain measure: The rate of occurrence of hypotension sex: ALL minimumAge: 60 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fayoum University hospital status: RECRUITING city: Fayoum state: Faiyum Governorate zip: 63514 country: Egypt name: Mohamed A Hamed, MD role: CONTACT phone: 01118560065 phoneExt: 02 email: mah07@fayoum.edu.eg name: Mahdy A Abdelhady, MD role: CONTACT phone: 0120363256 phoneExt: 02 email: maa45@fayoum.edu.eg lat: 29.30995 lon: 30.8418 hasResults: False