hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06336525 id: 2023P001895 id: R01HL164462 type: NIH link: https://reporter.nih.gov/quickSearch/R01HL164462 briefTitle: Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities. overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-01-31 date: 2027-01-31 date: 2024-03-28 date: 2024-04-22 name: Brigham and Women's Hospital class: OTHER name: University of Alabama at Birmingham name: Emory University name: University of Pennsylvania name: University of Massachusetts, Worcester name: The University of Texas Health Science Center at San Antonio name: Beth Israel Deaconess Medical Center name: National Heart, Lung, and Blood Institute (NHLBI) briefSummary: Rural communities in the southern U.S. suffer a disproportionate burden of morbidity and mortality from cardiometabolic disease, with traditional risk factors explaining only a modest proportion of the excess burden of disease. There is considerable evidence that multiple dimensions of sleep health, including sleep duration, efficiency, timing, and regularity, as well as the disorders sleep apnea and insomnia, affect cardiometabolic disease risk. However, there is currently a lack of systematically developed sleep data in rural populations. The RURAL Sleep Study is an ancillary study to a recently initiated longitudinal epidemiology study in rural Appalachia and Mississippi Delta (the RURAL Study). The RURAL Sleep Study will add measures of sleep health to the complex individual, social and environmental factors and health outcome measures being evaluated by the RURAL Study, by incorporating minimally burdensome measures of multiple dimensions of sleep health. The results are expected to inform health care providers, public health officials, and the general public of the prevalence, risk factors, and consequences of impaired sleep health in these rural communities, providing a critical basis for prevention, recognition, and management of sleep disorders and improvement of sleep and cardiometabolic health. conditions: Sleep Apnea conditions: Insomnia conditions: Sleep Deprivation conditions: Sleep Disorders, Circadian Rhythm conditions: Sleepiness, Excessive Daytime conditions: Fatigue studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 3680 type: ESTIMATED measure: Oxygen desaturation index measure: Insomnia Severity Index measure: Sleep Duration measure: Sleep Duration Regularity measure: Sleep Timing measure: Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep-related Impairment Short Form 8a measure: Restless Legs Syndrome (RLS) measure: Chronotype measure: Sleep Timing Regularity measure: Global Sleep Quality measure: Oxygen desaturation index, 3% sex: ALL minimumAge: 25 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Brigham and Women's Hospital city: Boston state: Massachusetts zip: 02115 country: United States lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06336512 id: RC.28.1.2024 briefTitle: Trimester Sequential Estimation of Serum Zonulin as a Predictor of Gestational Diabetes Mellitus overallStatus: COMPLETED date: 2023-01-15 date: 2023-07-01 date: 2023-10-01 date: 2024-03-28 date: 2024-03-28 name: Benha University class: OTHER briefSummary: Gestational diabetes mellitus (GDM) is the development of glucose intolerance (GI) during pregnancy in a previously normoglycemic (NG) woman and associated with insulin resistance (IR). GDM is the most prevalent metabolic disorder during pregnancy and became a major public health problem for being usually diagnosed and detected after 24 gestational weeks (GW), while its complications can occur much earlier and this may explain its burden on maternal and fetal welfare. Human zonulin is a surrogate marker of intestinal permeability and can be utilized as biomarker for intestinal barrier function. Zonulin-mediated increase in intestinal permeability plays a role in the pathogenesis of insulin resistance, obesity, DM and metabolic syndrome. The increasing global prevalence of GDM with its associated risk of poor pregnancy and long-term risks for the mother and the offspring may lead to the production of new generation of diabetics. conditions: Gestational Diabetes studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Newly Pregnant Women with singleton fetus primaryPurpose: DIAGNOSTIC masking: NONE count: 70 type: ACTUAL name: ELISA measure: Estimation of Gestational DM sex: FEMALE minimumAge: 22 Years maximumAge: 50 Years stdAges: ADULT facility: Benha university city: Banhā state: El- Qalyobia zip: 13511 country: Egypt lat: 30.45906 lon: 31.17858 hasResults: False
nctId: NCT06336499 id: TREC2023-KY107 briefTitle: Risk Stratification of Orbital Tumors Based on MRl and Artificial Intelligence overallStatus: COMPLETED date: 2012-01-01 date: 2022-10-31 date: 2023-12-31 date: 2024-03-28 date: 2024-03-29 name: Beijing Tongren Hospital class: OTHER briefSummary: Orbital tumors can be categorized into benign and malignant tumors, and there are significant variations in their biological behavior, treatment, and prognosis. This study aims to enhance the accurate diagnosis and risk stratification of orbital tumors using artificial intelligence (AI) technology and multiparameter magnetic resonance imaging (MRI) data. It further explores the intrinsic relationship between MRI and the differential diagnosis of benign and malignant orbital tumors, as well as the pathological subtypes of malignant tumors and Ki-67 expression levels. This research aims to aid in guiding personalized diagnosis and treatment decision-making for patients with orbital tumors while promoting the practical application and incorporation of AI technology. conditions: Orbital Neoplasms studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 600 type: ACTUAL name: Multi-parametric MRI and image analysis by deep learning or machine learning algorithms measure: The area under the curve of Receiver Operating Characteristic of the diagnostic models for the differential diagnosis of malignant and benign orbital tumors, high and low grades of histological types, and levels of Ki-67 expression in malignant ones. measure: The area under the Precision-Recall curve of the diagnostic models for the differential diagnosis of malignant and benign orbital tumors, high and low grades of histological types, and high and low levels of Ki-67 expression in malignant orbital tumors. measure: Sensitivity of the diagnostic models for the differential diagnosis of malignant and benign orbital tumors, high and low grades of histological types, and high and low levels of Ki-67 expression in malignant orbital tumors. measure: Specificity of the diagnostic models for the differential diagnosis of malignant and benign orbital tumors, high and low grades of histological types, and high and low levels of Ki-67 expression in malignant orbital tumors. measure: Accuracy of the diagnostic models for the differential diagnosis of malignant and benign orbital tumors, high and low grades of histological types, and high and low levels of Ki-67 expression in malignant orbital tumors. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06336486 id: BalikesirU-FTR-BG-01 briefTitle: the Effectiveness of Intermittent Pneumatic Compression on Neuropathic Pain in Patients With Diabetic Polyneuropathy overallStatus: COMPLETED date: 2018-12-04 date: 2020-02-01 date: 2020-02-01 date: 2024-03-28 date: 2024-04-01 name: Busra Gunes class: OTHER briefSummary: In this study,the effectiveness of intermittent pneumatic compression therapy on neuropathic pain and quality of life in patients with neuropathic pain due to type 2 diabetes was investigated conditions: Diabetic Neuropathic Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: two groups with a conventional therapy control group primaryPurpose: TREATMENT masking: NONE count: 50 type: ACTUAL name: intermittent pneumatic compression +pregabalin group name: pregabalin group measure: The Leeds assessment of neuropathic symptoms and signs(LANSS) measure: Pain quality rating scale(PQAS) measure: Visual Analog Scale(VAS) measure: 36-Item Short Form Health Survey(SF-36) sex: ALL minimumAge: 40 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Balıkesir University city: Balıkesir state: Merkez zip: 10050 country: Turkey lat: 39.64917 lon: 27.88611 hasResults: False
nctId: NCT06336473 id: 2023-A02097-38 briefTitle: Evaluation of the Effects of Cross Linking on the Biomechanical Characteristics of Skin Samples From Patients With Classic or Hypermobile Ehlers-Danlos Syndrome acronym: SEDSKIN overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-07-31 date: 2024-03-28 date: 2024-03-28 name: GCS Ramsay Santé pour l'Enseignement et la Recherche class: OTHER briefSummary: The main aim of this study is to evaluate the effect of cross linking on the elasticity of skin samples from patients with non-vascular Ehlers-Danlos Syndrome (hEDS or cEDS). conditions: Ehlers-Danlos Syndrome studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single-center study performed on biopsied skin samples primaryPurpose: BASIC_SCIENCE masking: NONE count: 28 type: ESTIMATED name: skin biopsy measure: Young's modulus quantification measure: Collagen fibril diameter measurement measure: Collagen fibril D-period length measurement sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clinique Maussins-Nollet city: Paris zip: 75019 country: France lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06336460 id: 2023-537 briefTitle: PENG vs. FIC Blocks in Hip Fractures in the ED overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-04-01 date: 2024-03-28 date: 2024-03-28 name: Orange Park Medical Center class: OTHER briefSummary: This study is a prospective, randomized clinical trial assessing the efficacy of physician-performed ultrasound-guided pericapsular nerve group (PENG) block vs fascia iliaca compartment (FIC) block for pain control in acute hip fracture. conditions: Hip Fractures conditions: Nerve Block conditions: Analgesia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: The research associate/outcome assessor will not have access to group assignment and will therefore be blinded to the type of block. Although the patient, their caregiver(s), and the clinician caring for the patient will not be directly informed of the group assignment, a note will be logged in the clinical record by the physician placing the block indicating the details of the block after this procedure has been completed. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Pericapsular Nerve Group (PENG) Block name: Fascia Iliaca Compartment (FIC) Block for Patients with Isolated Hip Fractures measure: Numeric pain score at 30 minutes measure: Numeric pain score at 60 minutes measure: Cumulative Morphine Milligram Equivalents in 24 hours after enrollment sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06336447 id: STU00220295 briefTitle: VR and Cooled Genicular Nerve Radio Frequency Ablation for Chronic Knee Pain overallStatus: RECRUITING date: 2024-01-12 date: 2026-12-31 date: 2027-02-28 date: 2024-03-28 date: 2024-03-28 name: Northwestern University class: OTHER briefSummary: This study will examine the impact of virtual reality used in conjunction with sedation compared to sedation alone in patients undergoing watervcooled genicular nerve ablations for chronic knee pain.
The goals of the study is to determine the relative efficacy of virtual reality as a distraction modality when used as an adjuvant to procedural sedation compared to sedation alone for procedure related pain. To assess procedural satisfaction, and 1-month pain and functional outcomes.To explore whether virtual reality and lower procedure-related pain scores affect 1-month outcomes. And finally to determine whether demographic and clinical characteristics are associated with outcome measures. conditions: Pain, Chronic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized controlled trail. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Outcome assessor will be blinded to study randomization whoMasked: OUTCOMES_ASSESSOR count: 62 type: ESTIMATED name: Experimental: Group #1: Virtual Reality Headset name: Group 2 No Virtual Reality Headset measure: Procedural related pain measure: Procedure related satisfaction measure: Post procedure anxiety measure: Mean reduction in pain 1 month after procedure measure: Midazolam administered measure: Fentanyl administered sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Northwestern Medicine Pain Center status: RECRUITING city: Chicago state: Illinois zip: 60611 country: United States name: Paul Fitzgerald role: CONTACT phone: 312-695-1064 email: p-fitzgerald2@northwestern.edu name: Jason Ross, MD role: PRINCIPAL_INVESTIGATOR lat: 41.85003 lon: -87.65005 hasResults: False
nctId: NCT06336421 id: Şuletuvanç briefTitle: The Effect of Virtual Reality Application on Perceived Anxiety and Vital Signs in Primiparous overallStatus: COMPLETED date: 2022-11-01 date: 2023-06-15 date: 2024-03-22 date: 2024-03-28 date: 2024-03-28 name: Ataturk University class: OTHER briefSummary: Purpose: To determine the effect of virtual reality application on anxiety and vital signs perceived by primiparous women during cesarean section.The research was conducted in a randomized controlled experimental design.The population of the research consisted of primiparous pregnant women with a caesarean section indication in the Ataturk University Health Research and Application Center Gynecology Clinic Operating Room. conditions: Cesarean Section Complications studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: statistics expert whoMasked: OUTCOMES_ASSESSOR count: 90 type: ACTUAL name: Virtual Reality measure: Personal Information Form measure: State Anxiety Scale measure: Pregnant follow-up form sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Ayse Aydin city: Yakutiye state: Erzurum zip: 25000 country: Turkey lat: 39.89821 lon: 41.26916 hasResults: False
nctId: NCT06336408 id: B2023-370R briefTitle: The SLEEP-CARE Study overallStatus: RECRUITING date: 2024-02-01 date: 2025-12-31 date: 2025-12-31 date: 2024-03-28 date: 2024-03-28 name: Shanghai Zhongshan Hospital class: OTHER briefSummary: Sleep disorder is common in ICU patients, such as reduced sleep time, fragmentation, and abnormal sleep rhythm. In 2023, American Thoracic Society released a research statement on sleep and circadian disruption(SCD) in ICU, which considered SCD is an important potential target for improving critical illness outcomes. Although polysomnography(PSG) is the gold standard of sleep measurement, subjective sleep evaluation tools are still used in most clinical studies related to sleep in ICU. This makes the sleep quality of ICU patients overestimated and difficult to reflect their true sleep conditions. And the answers to how and which outcomes different levels of sleep deprivation affect patient outcomes are still unclear and need to be further explored. conditions: Sleep Disturbance studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 80 type: ESTIMATED measure: Compound outcome index measure: LOS sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Zhongshan Hospital, Fudan University status: RECRUITING city: Shanghai country: China name: Jingjing Li, Master role: CONTACT phone: 13512106878 email: li.jingjing@zs-hospital.sh.cn lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06336395 id: 2019/00888 briefTitle: Ma-Spore ALL 2020 Study overallStatus: RECRUITING date: 2020-03-04 date: 2030-03 date: 2030-03 date: 2024-03-28 date: 2024-03-28 name: National University Hospital, Singapore class: OTHER briefSummary: The primary objective of this trial is to improve the overall survival rate of children and young adult with B-lineage acute lymphoblastic leukemia (B-ALL) in Singapore and Malaysia in the context of a multicenter cooperative trial using a risk-stratified therapy. conditions: B Lymphoblastic Leukemia studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 500 type: ESTIMATED name: Prednisolone name: Dexamethasone name: Vincristine name: Methotrexate name: L-Asparaginase name: Pegylated asparaginase name: Erwinase name: Dasatinib name: Imatinib name: Cyclophosphamide name: Cytarabine name: Mercaptopurine name: Thioguanine name: Rituximab name: Doxorubicin name: Fludarabine measure: Overall survival (OS) measure: Event free survival (EFS) measure: Cumulative incidence (CI) of relapse for all treated cohorts measure: Cumulative incidence (CI) of therapy-related mortality (TRM) for all treated subjects sex: ALL maximumAge: 40 Years stdAges: CHILD stdAges: ADULT facility: Subang Jaya Medical Centre status: RECRUITING city: Kuala Lumpur zip: 47500 country: Malaysia name: Hai Peng Lin role: CONTACT phone: +603 56391621 email: flslhp@gmail.com name: Lee Lee Chan, MBBS role: SUB_INVESTIGATOR lat: 3.1412 lon: 101.68653 facility: University Malaya Medical Centre status: RECRUITING city: Kuala Lumpur zip: 59100 country: Malaysia name: Hany Arrifin, MBBS role: CONTACT phone: +603 79492065 email: hany@ummc.edu.my lat: 3.1412 lon: 101.68653 facility: KK Women's and Children's Hospital status: RECRUITING city: Singapore zip: 229899 country: Singapore name: Ah Moy Tan, MBBS role: CONTACT phone: +65 63941039 email: tan.ah.moy01@singhealth.com.sg lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06336382 id: 23-0874 id: 1R21MH135148 type: NIH link: https://reporter.nih.gov/quickSearch/1R21MH135148 briefTitle: Tau Biomarkers in Late-onset Psychosis (LOP) overallStatus: RECRUITING date: 2024-02-16 date: 2026-12-31 date: 2027-06-30 date: 2024-03-28 date: 2024-03-28 name: Jeremy Koppel class: OTHER name: National Institute of Mental Health (NIMH) briefSummary: Hallucinations or delusions that occur for the first time in older people with no acute medical problems or mood symptoms may be related to impending dementia. This study aims to confirm this hypothesis using novel blood biomarkers and Positron Emission Tomography (PET) imaging tracers, as well as non-invasive testing. conditions: Late Onset Schizophrenia conditions: Delusional Disorder (Late Onset) studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 16 type: ESTIMATED name: Tau PET imaging scan measure: Quantification of neurofibrillary tangle pathology in subjects via PET [18F]PI-2620 radiotracer uptake. measure: Measurement of peripheral soluble tau pathology with tau plasma immunoassays. measure: Evaluation of sensorimotor gating integrity and it's association to tau PET ligand uptake. sex: ALL minimumAge: 65 Years maximumAge: 85 Years stdAges: OLDER_ADULT facility: The Feinstein Institutes for Medical Research status: RECRUITING city: Manhasset state: New York zip: 11030 country: United States name: Erica Christen, MS role: CONTACT phone: 516-562-3492 email: EChriste@northwell.edu name: Michelle Gong, AS role: CONTACT phone: 516-562-3492 email: MGong@northwell.edu lat: 40.79788 lon: -73.69957 hasResults: False
nctId: NCT06336369 id: 1713/2023 briefTitle: Brown Adipose Tissue Activity in Gilbert's Syndrome overallStatus: RECRUITING date: 2024-03-06 date: 2027-01-15 date: 2027-01-15 date: 2024-03-28 date: 2024-03-28 name: Medical University of Vienna class: OTHER name: University of Vienna name: Griffith University briefSummary: The goal of this case-control study is to investigate energy metabolism and brown adipose tissue (BAT) activity in individuals with Gilbert's syndrome (GS) and controls. The main focus of the study is to analyze:
Researchers will compare individuals with GS and control subjects in terms of metabolic health, body composition and BAT activity. conditions: Gilbert Syndrome studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 80 type: ESTIMATED name: analyzing brown adipose tissue, body composition and metabolic health measure: cold-induced brown adipose tissue (BAT) activation sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Medical University of Vienna status: RECRUITING city: Vienna zip: 1090 country: Austria name: Florian Kiefer, MD, PhD role: CONTACT phone: +43140400 phoneExt: 43120 email: florian.kiefer@meduniwien.ac.at lat: 48.20849 lon: 16.37208 hasResults: False
nctId: NCT06336356 id: D6970C00011 briefTitle: A Study to Evaluate Cortisol Reserve in Response to Adrenocorticotropic Hormone (ACTH) Stimulation Test Following Baxdrostat Treatment Compared to Placebo in Participants With Uncontrolled Hypertension overallStatus: NOT_YET_RECRUITING date: 2024-05-13 date: 2024-11-05 date: 2024-11-05 date: 2024-03-28 date: 2024-03-28 name: AstraZeneca class: INDUSTRY briefSummary: The main purpose of this study is to assess the serum free cortisol response after ACTH stimulation test at baseline and at Week 8 in participants with uncontrolled hypertension. conditions: Uncontrolled Hypertension studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 45 type: ESTIMATED name: Baxdrostat name: Placebo measure: Individual Cortisol Level measure: Number of Participants with Abnormal Stimulated Cortisol sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06336343 id: STUDY-23-01698 briefTitle: Bimekizumab in Plaque Psoriasis overallStatus: RECRUITING date: 2024-03 date: 2025-10-31 date: 2025-10-31 date: 2024-03-28 date: 2024-03-28 name: Icahn School of Medicine at Mount Sinai class: OTHER name: UCB Pharma name: Psoriasis Treatment Center of Central New Jersey briefSummary: The purpose of this research study is to evaluate the effectiveness and safety of bimekizumab in individuals with moderate-to-severe psoriasis who have failed similar therapies. Bimekizumab improves psoriasis by suppressing a type of substance found in bodies called interleukins (specifically, interleukins 17a and 17F), which are known to increase inflammation. This study will look at the effectiveness of bimekizumab in psoriasis patients that have failed previous therapies that target interleukin IL-17A or 23. conditions: Plaque Psoriasis studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Bimekizumab measure: Body Surface Area (BSA) of < 1 measure: Psoriasis and Severity Index Score (PASI) of < 1 measure: Physician Global Assessment (PGA) of < 1 measure: Psoriasis and Severity Index Score (PASI) of < 2 measure: Physician Global Assessment (PGA) of < 2 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Windsor Dermatology - Psoriasis Treatment Center of Central New Jersey status: RECRUITING city: East Windsor state: New Jersey zip: 08520 country: United States name: Elise Nelson role: CONTACT phone: 609-443-4500 name: Jerry Bagel role: PRINCIPAL_INVESTIGATOR lat: 40.268 lon: -74.54043 facility: Icahn School of Medicine at Mount Sinai status: RECRUITING city: New York state: New York zip: 10029 country: United States name: Giselle Singer role: CONTACT phone: 212-241-3288 name: Mark Lebwohl role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 hasResults: False