hackint0sh/New-Dataset huggingface dataset:
This is a randomized, controlled trial comparing DTx lifestyle intervention in participants with non-cirrhotic MASH to standard clinical care. The study includes a screening period (up to 2 wks.) followed by randomization, 48-wk treatment period and 12-wk follow-up period (total duration up to 62 wks.). conditions: NASH conditions: NASH - Nonalcoholic Steatohepatitis conditions: Liver Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 50/50 randomization primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Noom Weight Application measure: Clinically significant liver fat loss measure: Sustained clinically significant body weight loss measure: Sustained clinically significant body weight loss measure: Liver fat and liver stiffness using imaging analysis measure: Liver fat and liver stiffness using imaging analysis measure: Liver fat and liver stiffness using imaging analysis measure: Liver fat and liver stiffness using imaging analysis measure: Liver fat and liver stiffness using imaging analysis measure: Liver fat and liver stiffness using imaging analysis measure: Clinically meaningful improvement in liver fat and stiffness measure: Clinically meaningful improvement in liver fat and stiffness measure: Clinically meaningful improvement in liver fat and stiffness measure: Clinically meaningful improvement in liver fat and stiffness measure: Clinically meaningful improvement in liver fat and stiffness measure: Clinically meaningful improvement in liver fat and stiffness measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of hepatic injury measure: Circulating biomarkers of liver fibrosis and fibrogenesis measure: Circulating biomarkers of liver fibrosis and fibrogenesis measure: Circulating biomarkers of liver fibrosis and fibrogenesis measure: Circulating biomarkers of liver fibrosis and fibrogenesis measure: Circulating biomarkers of liver fibrosis and fibrogenesis measure: Circulating biomarkers of liver fibrosis and fibrogenesis sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06352164 id: ZYS2024-03 briefTitle: Efficacy Classification Prediction of the Effects of Acupuncture on Abdominal Pain in Patients With Crohn's Disease overallStatus: COMPLETED date: 2015-03-01 date: 2023-12-31 date: 2024-03-31 date: 2024-04-08 date: 2024-04-09 name: Shanghai Institute of Acupuncture, Moxibustion and Meridian class: OTHER briefSummary: Machine learning algorithms are applied to discover gut flora markers that predict the clinical efficacy of acupuncture, so as to screen the appropriate population for acupuncture and optimise the allocation of healthcare resources. conditions: Crohn Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 55 type: ACTUAL name: Acupuncture treatment measure: Characterisation of gut microflora strains predictive of acupuncture efficacy sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai Institute of Acupuncture, Moxibustion and Meridian city: Shanghai zip: 200000 country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06352151 id: 2022-041 briefTitle: Effects of Orofacial Therapy and Therapeutic Yoga in Children With Down Syndrome overallStatus: RECRUITING date: 2023-10-01 date: 2024-09-28 date: 2024-12-30 date: 2024-04-08 date: 2024-04-09 name: Hasan Kalyoncu University class: OTHER briefSummary: The study aims to compare the effects of orofacial therapy and therapeutic yoga on swallowing, sleep habits, and quality of life in children with Down syndrome. conditions: Down Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 30 type: ESTIMATED name: Routine Physiotherapy Group name: Orofacial Treatment Group name: Therapeutic Yoga Group measure: The Pediatric Functional Independence Measure measure: Pediatric Eating Assessment Tool-10 measure: Children's Sleep Habits Questionnaire measure: The Health-Related Quality of Life Scale-KIDSCREEN-27 sex: ALL minimumAge: 5 Years maximumAge: 12 Years stdAges: CHILD facility: Hasan Kalyoncu University status: RECRUITING city: Gaziantep zip: 27410 country: Turkey name: Aysenur Tuncer, PhD role: CONTACT phone: +903422118080 name: Yasemin Kotevoglu, MSc role: CONTACT lat: 37.05944 lon: 37.3825 hasResults: False
nctId: NCT06352138 id: ENCASE briefTitle: Comparative Study of Two Recombinant Human Erythropoietin Products on Chronic Kidney Disease Patients acronym: ENCASE overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2027-03 date: 2027-03 date: 2024-04-08 date: 2024-04-08 name: Megalabs class: INDUSTRY name: Azidus Laboratories briefSummary: Phase III, multicentre, double-blind, randomised, parallel, equivalence clinical trial to determine the efficacy, safety and immunogenicity of Megalabs® recombinant human alfa epoetin for subcutaneous use, compared to Eprex® (Janssen-Cilag Farmacêutica Ltda.), in the treatment of anaemia in participants with chronic renal disease, dependent on haemodialysis conditions: Anemia of Chronic Kidney Disease studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: multicentre, double-blind, randomised, parallel, equivalence trial primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 280 type: ESTIMATED name: Experimental: Epoetin alfa Megalabs® Erythropoietin injectable in intravenous administration. name: Active comparator: European Union licenced epoetin alfa measure: Mean Absolute Change in Hemoglobin Levels measure: Change in Mean Hb Level measure: immunogenicity sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Megalabs city: Colonia Nicolich state: Canelones zip: 15000 country: Uruguay name: Victoria Rodriguez, MD role: CONTACT phone: 26836300 phoneExt: 3110 email: vrodriguez@megalabs.global lat: -34.81516 lon: -56.02435 hasResults: False
nctId: NCT06352125 id: TP-CLN-100503 briefTitle: An Observational Trial to Assess the Performance of the TEG® 6s Diagnostic System With the Citrated K, KH, RTH, FFH Cartridge overallStatus: COMPLETED date: 2021-12-09 date: 2023-01-31 date: 2023-01-31 date: 2024-04-08 date: 2024-04-08 name: Haemonetics Corporation class: INDUSTRY name: ClinStatDevice name: Boston Healthcare Technologies Consultants, LLC briefSummary: This clinical trial is designed to assess the agreement of the TEG® 6s system using the Citrated K, KH, RTH, FFH, cartridge (hereafter referred to as the Heparin Neutralization (HN) Cartridge) with its comparators. conditions: Surgery studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 338 type: ACTUAL name: TEG 6s Citrated K, KH, RTH, FFH Cartridge name: Clauss Fibrinogen measure: Primary Method Comparison measure: Primary Method Comparison measure: Primary Method Comparison measure: Primary Method Comparison measure: Primary Method Comparison measure: Primary Method Comparison measure: Primary Method Comparison sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of California - San Francisco city: San Francisco state: California zip: 94143 country: United States lat: 37.77493 lon: -122.41942 facility: University of Colorado city: Aurora state: Colorado zip: 80045 country: United States lat: 39.72943 lon: -104.83192 facility: Ochsner Clinic city: New Orleans state: Louisiana zip: 70121 country: United States lat: 29.95465 lon: -90.07507 facility: Lifebridge Health (Sinai Hospital) city: Baltimore state: Maryland zip: 21215 country: United States lat: 39.29038 lon: -76.61219 facility: Massachusetts General Hospital city: Boston state: Massachusetts zip: 02114 country: United States lat: 42.35843 lon: -71.05977 facility: University of Pittsburgh Medical Center city: Pittsburgh state: Pennsylvania zip: 15213 country: United States lat: 40.44062 lon: -79.99589 facility: University of Texas Health Science Center - San Antonio city: San Antonio state: Texas zip: 78229 country: United States lat: 29.42412 lon: -98.49363 hasResults: False
nctId: NCT06352112 id: 02.04.2024 - POP briefTitle: Effects of the Hypopressive Exercises in Women With Pelvic Organ Prolapse overallStatus: COMPLETED date: 2023-03-15 date: 2024-01-15 date: 2024-02-15 date: 2024-04-08 date: 2024-04-10 name: Hacettepe University class: OTHER name: Istanbul Training and Research Hospital briefSummary: The aim of this study was compare home-based pelvic floor muscle training (PFMT) alone and home-based PFMT combined with hypopressive exercise (HE) in terms of pelvic floor muscle (PFM) activation and severity of pelvic floor dysfunction (PFD) in women with pelvic organ prolapse (POP) for eight weeks. For this purpose, the participants were randomly divided into two groups: \[PFMT alone (n:15) and PFMT combined with HE(n:17)\]. DuoBravo EMG device for evaluation of PFM activation and "Pelvic Floor Distress Inventory-20" was used to evaluate the severity of PFD. All evaluations were performed twice in total, at baseline and at week 8. conditions: Pelvic Floor Disorders conditions: Prolapse; Female studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 32 type: ACTUAL name: Pelvic Floor Muscle Training name: Hypopressive Exercises measure: Pelvic Floor Muscle Activation measure: Severity of pelvic floor dysfunction sex: FEMALE minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT facility: Istanbul Research and Training Hospital city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06352099 id: 6315 briefTitle: Dietary Supplementation and Cognitive Functions in the Elderly acronym: ESPINS overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-11 date: 2025-04 date: 2024-04-08 date: 2024-04-08 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: In recent years, globally, there has been a growth in both the size and the proportion of older adults in the world population. The World Health Organization (WHO) has estimated that by 2030, 1 in 6 people will be 60 years of age or older, and that by 2050, the population of older adults will reach 2.1 billion. The population of older adults (over 80 years) will triple to 426 million by 2050. In particular, Italy represents the second country with the oldest population in the world.
Age-related evolution is a gradual and continuous process involving a series of physical and cognitive changes, which, however, has no real 'onset' age. In fact, rather than chronological age, the concept of 'elderly' is based on the individual's degree of self-sufficiency and independence. From a biological point of view, ageing is the set of changes at the molecular and cellular level that occur over time and lead to multi-system functional impairment. It is a process directly related to frailty, falls, and disability.
An important factor in counteracting frailty is nutritional intake. Humans ingest approximately 500 g of chemical compounds daily through their diet, most of which are components of plants or vegetables in general. In addition to the well-known macronutrients (proteins, fats, and carbohydrates) and micronutrients (minerals and vitamins), the plant world provides other elements, such as phenols, terpenes, terpenoids, alkaloids, purines, pyrimidines, nucleic acids, and steroids, that exert powerful biological activities. These components are generically called phytochemicals. Epidemiological studies have established that diets rich in plant-based foods help prevent many diseases, such as cardiovascular, metabolic, neurovegetative, and inflammatory diseases.
Among the phytochemical compounds, flavonoids represent a category of polyfunctional substances with high bioactivity, comprising more than 5000 compounds. They possess biochemical properties of functional interest in the nutritional and therapeutic fields; for example, rutin, diosmin, and hesperidin are present in some pharmaceutical specialties; flavonoids from ginkgo biloba, hawthorn, and red vine are the main components of many phytotherapeutic extracts. Flavonoids have been shown to play an important role in cardioprotection. Furthermore, in neuroprotection, anthocyanin-rich fruits play a protective role against age-related decline in cognitive functions.
The aim of the study is to evaluate the contribution of dietary supplementation with Altemor® on cognitive function, balance, fatigue, and some domains of quality of life in elderly subjects. conditions: Cognitive Impairment conditions: Old Age; Debility studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 36 type: ESTIMATED name: Dietary supplement with micronised diosmin, hesperidin and herbal extracts measure: Trial Making Test (TMT) measure: Short Physical Performance Battery (SPPB) measure: HandGrip Strenght Test (HGST) measure: Silver Index (SI) measure: Mental Deterioration battery (MDB) measure: Hospital Anxiety and Depression Scale (HADS) measure: EuroQol- 5 Dimension (EQ-5D) measure: Modified Fatigue Impact Scale (MFIS) sex: ALL minimumAge: 50 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione Policlinico Universitario A. Gemelli IRCCS city: Roma state: RM zip: 00168 country: Italy name: Silvia Giovannini, MD, PhD role: CONTACT phone: +390630154382 email: silvia.giovannini@policlinicogemelli.it name: Letizia Castelli, PhD role: CONTACT phone: +390630154382 email: letizia.castelli@policlinicogemelli.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06352086 id: STUDY00009227 briefTitle: Understanding Visual Processing After Occipital Stroke overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2028-09 date: 2029-09 date: 2024-04-08 date: 2024-04-08 name: University of Rochester class: OTHER briefSummary: The purpose of this study is to investigate how visual orientation discrimination and metacognition (i.e., perceptual confidence) are affected by occipital stroke that causes hemianopia and quadrantanopia in adults. This research will provide insight as to how the residual visual system, which not directly damaged by the occipital stroke, processes orientation (assayed in terms of orientation discrimination) and metacognition (by measuring perceptual confidence for orientation discrimination). These measures will be used to refine computational models that attempt to explain how the brain copes with loss of primary visual cortex (V1) as a result of stroke. This knowledge is essential to devise more effective visual rehabilitation therapies for patients suffering from occipital strokes. conditions: Vision Loss Partial conditions: Vision; Loss, Both Eyes conditions: Hemianopia, Homonymous conditions: Hemianopia conditions: Quadrantanopia conditions: Stroke, Ischemic conditions: Stroke - Occipital Infarction conditions: Cortical Blindness conditions: Occipital Lobe Infarct conditions: Peripheral Visual Field Defect of Both Eyes studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 20 type: ESTIMATED measure: Orientation discrimination threshold measure: Perceptual Confidence in Orientation Discrimination sex: ALL minimumAge: 21 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06352073 id: 23-2625 id: R668-EE-2380 type: OTHER domain: Regeneron briefTitle: Dupilumab for Eosinophilic Esophagitis With Severe Strictures acronym: DESTRICT overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-11 date: 2026-04 date: 2024-04-08 date: 2024-04-08 name: University of North Carolina, Chapel Hill class: OTHER name: Regeneron Pharmaceuticals name: Sanofi briefSummary: The purpose of this research study is to determine how well an FDA-approved drug, dupilumab, works to treat patients with severe strictures and active Eosinophilic Esophagitis (EoE). This is an open-label study, meaning everyone in the study will receive dupilumab.
Participants will have a screening visit where they will complete surveys and undergo an endoscopy (EGD). Blood and biopsies (small tissue samples) will also be collected. If eligible and enrolled into the study, participants will receive weekly subcutaneous (under the skin) injections of dupilumab for 52 weeks (one year). The first dose of dupilumab will be administered at the week 1 visit by a clinician and participants will receive training on how to self-administer the remaining doses.
At 64 weeks (12 weeks after the last dose of dupilumab), participants assigned male at birth (AMAB) will be contacted about their / their partner's pregnancy status and participants assigned female at birth (AFAB) may be asked to come for an in-person visit to complete a urine pregnancy test. conditions: Eosinophilic Esophagitis conditions: EoE studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Dupilumab measure: Histologic Response to Dupilumab measure: Change in Minimum Esophageal Caliber measure: Decrease in Number of Dilations measure: Change in Endoscopic Severity measure: Change in Histologic Severity sex: ALL minimumAge: 16 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: University of North Carolina at Chapel Hill city: Chapel Hill state: North Carolina zip: 27599 country: United States name: Julia Phillips role: CONTACT phone: 919-843-4453 email: julia_phillips@med.unc.edu name: Hiwot Ekuban role: CONTACT email: hiwot_ekuban@med.unc.edu lat: 35.9132 lon: -79.05584 hasResults: False
nctId: NCT06352060 id: KCHRRF_MONITOR AF_030 briefTitle: Dynamic Data-Driven Management of Atrial Fibrillation Using Implantable Cardiac Monitors: The MONITOR-AF Study overallStatus: RECRUITING date: 2024-04 date: 2024-06 date: 2024-09 date: 2024-04-08 date: 2024-04-08 name: Kansas City Heart Rhythm Research Foundation class: OTHER briefSummary: Observational, multi-center, retrospective study to evaluate the use of ICM (implantable cardiac monitor) versus traditional, non-ICM (non-implantable cardiac monitor) methods such as ECGs (electrocardiogram), Holter, and mobile cardiac outpatient telemetry (MCOT) units. conditions: Atrial Fibrillation studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 2500 type: ESTIMATED name: No intervention or administration will be performed due to the observational nature of the study measure: No.of patients with arrhythmia recurrence measure: No.of patients with redo ablation sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Menorah Medical Center status: RECRUITING city: Overland Park state: Kansas zip: 66209 country: United States name: Donita Atkins role: CONTACT lat: 38.98223 lon: -94.67079 facility: Kansas City Heart Rhythm Institute - Roe Clinic status: RECRUITING city: Overland Park state: Kansas zip: 66211 country: United States name: Donita Atkins role: CONTACT phone: 816-651-1969 email: Datkins@kchrf.com name: Naga Venkata K. Pothineni, MD role: PRINCIPAL_INVESTIGATOR lat: 38.98223 lon: -94.67079 facility: Overland Park Regional Medical Center status: RECRUITING city: Overland Park state: Kansas zip: 66215 country: United States name: Donita Atkins role: CONTACT phone: 816-651-1969 email: datkins@kchrf.com name: Naga Venkata K. Pothineni role: PRINCIPAL_INVESTIGATOR lat: 38.98223 lon: -94.67079 facility: Centerpoint Medical Center Clinic status: RECRUITING city: Independence state: Missouri zip: 64057 country: United States name: Donita Atkins role: CONTACT lat: 39.09112 lon: -94.41551 facility: Centerpoint Medical Center status: RECRUITING city: Independence state: Missouri zip: 64057 country: United States name: Donita Atkins role: CONTACT lat: 39.09112 lon: -94.41551 facility: Research Medical Center Clinic status: RECRUITING city: Kansas City state: Missouri zip: 64032 country: United States name: Donita Atkins role: CONTACT phone: 816-651-1969 email: Datkins@kchrf.com name: Naga Venkata K. Pothineni, MD role: PRINCIPAL_INVESTIGATOR lat: 39.09973 lon: -94.57857 facility: Research Medical Center status: RECRUITING city: Kansas City state: Missouri zip: 64032 country: United States name: Donita Atkins role: CONTACT phone: 816-651-1969 email: Datkins@kchrf.com name: Naga Venkata K. Pothineni, MD role: PRINCIPAL_INVESTIGATOR lat: 39.09973 lon: -94.57857 hasResults: False
nctId: NCT06352047 id: Karadeniz Tech. University briefTitle: The Effects of Positioning After Extubation of Preterm Infants on the Respiratory Functions overallStatus: COMPLETED date: 2018-11-01 date: 2019-06-01 date: 2019-06-01 date: 2024-04-08 date: 2024-04-08 name: Karadeniz Technical University class: OTHER briefSummary: The aim of this study was to examine the effect of positioning on respiratory functions of preterm infants after extubation.
Hypothesis 0d (H0d): There is no difference between respiratory distress in preterm infants in supine and prone positions after extubation. conditions: Premature Infants studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Simple randomization method was used in the sample of the study. In previous studies, there were no published data on the effect of supine and prone positioning after extubation on the pulmonary functions of premature infants. Therefore, the sample size was calculated using the G-power 3.1.3 program according to the SpO2 level and standard deviation values of 4 infants who were mechanically ventilated in the neonatal intensive care unit. The study was conducted with a total of 42 premature babies, two groups of 21 premature babies, each of whom had the characteristics of the research groups. Premature infants were divided into two groups, the supine position and the prone group, by randomization using a computer-based random number generator (www.randomizer.org). primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 42 type: ACTUAL name: The effect of positioning on respiratory functions of preterm infants after extubation. measure: Newborn Evaluation Form sex: ALL minimumAge: 37 Weeks maximumAge: 37 Weeks stdAges: CHILD facility: İlknur Kahriman city: Trabzon zip: 61080 country: Turkey lat: 41.005 lon: 39.72694 facility: Karadeniz Technical University Health Application and Research Center Farabi Hospital city: Trabzon zip: 61080 country: Turkey lat: 41.005 lon: 39.72694 hasResults: False