hackint0sh/New-Dataset huggingface dataset:
This study is anticipated to take only around 2.5 hour per patient to complete. Patients meeting the inclusion and exclusion criteria of this study are placed on IHNRM and monitored until steady state of SpO2 of 95% or higher on 7-10 LPM has been maintained for at least 2 hours, when they can be discharged from the post-anesthesia care unit (PACU) to the regular care ward.
The study is the parallel design study. 60 patients will be randomly selected to use the IHNRM, and 30 subjects will be placed on HFNC. Blood oxygen concentration (SpO2), respiratory rate, end tidal CO2 concentration (EtCO2), and vital sign will be recorded in the study. The endpoint of the study is to compare the effect after using between "IHNRM" and HFNC. conditions: Respiratory Disease conditions: Respiratory Distress Syndrome conditions: Respiratory Failure studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 90 type: ESTIMATED name: High Flow Nasal Cannula name: "Intrinseque Health" Non-Rebreathing Mask ("IHNRM") measure: Time to reach SpO2 Criteria in Run-in measure: The percentage of subjects to reach SpO2 Criteria in maintenance sex: ALL minimumAge: 3 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Internal Medicine, China Medical Univdersity Hospital status: RECRUITING city: Taichung country: Taiwan name: Chih-Chihng Yen, MD, PhD role: CONTACT phone: 886-4-22052121 phoneExt: 3483 email: d5210@mail.cmuh.org.tw name: Chih-Ching Yen, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 24.1469 lon: 120.6839 hasResults: False
nctId: NCT06310616 id: 219888 briefTitle: A Study to Investigate the Potential Drug-Drug Interaction Between VH4524184 and Oral Contraceptive (Loestrin) in Healthy Adult Female Participants overallStatus: RECRUITING date: 2024-03-06 date: 2024-05-28 date: 2024-05-28 date: 2024-03-15 date: 2024-03-15 name: ViiV Healthcare class: INDUSTRY briefSummary: This study aims to assess any impact of VH4524184 on the pharmacokinetic (PK) profile of an ethinyl estradiol (EE) and norethindrone acetate (NEA) containing oral contraceptive (OC) administered to healthy adult female participants. conditions: HIV Infections studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 25 type: ESTIMATED name: VH4524184 name: Loestrin measure: Area under the concentration-time curve (AUC) from time zero (pre-dose) to the end of the dosing interval at steady state (AUC0-Tau, ss) of EE and NEA without coadministration with VH4524184 measure: AUC0-Tau, ss of EE and NEA with coadministration with VH4524184 measure: Maximum plasma concentration (Cmax) for EE and NEA without coadministration with VH4524184 measure: Cmax for EE and NEA with coadministration with VH4524184 measure: Number of participants with adverse events (AEs) and severity of AEs measure: Number of participants with AEs leading to discontinuation of study intervention measure: Change from baseline of liver panel laboratory parameters: Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ASP) (International units per liter) measure: Change from baseline of liver panel laboratory parameters: Total bilirubin, Direct bilirubin (Micromoles per liter [umol/L]) measure: Change from baseline of liver panel laboratory parameters: International normalized ratio (INR) (Ratio) measure: Number of participants with maximum toxicity grade increase from baseline of liver panel laboratory parameters: ALT, AST, alkaline phosphatase, total bilirubin, Direct bilirubin, and INR measure: Maximum plasma concentration at steady state (Cmax,ss) for VH4524184 measure: Time to maximum concentration at steady state (Tmax, ss) during dosing interval for VH4524184 measure: Area under the concentration-time curve from time zero(pre-dose) to the end of the dosing interval at steady state (AUC0-Tau, ss) for VH4524184 measure: Trough concentration prior to the next dose (Ctrough) for VH4524184 sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: GSK Investigational Site status: RECRUITING city: San Antonio state: Texas zip: 78209 country: United States name: US GSK Clinical Trials Call Center role: CONTACT phone: 877-379-3718 email: GSKClinicalSupportHD@gsk.com name: EU GSK Clinical Trials Call Centre role: CONTACT phone: +44 (0) 20 8990 4466 email: GSKClinicalSupportHD@gsk.com name: Chinonye Chika Ogbonnaya-Odor role: PRINCIPAL_INVESTIGATOR lat: 29.42412 lon: -98.49363 hasResults: False
nctId: NCT06310603 id: IRB-23-42 briefTitle: Determinants and Outcomes of High vs. Low Ultra-processed Feeding overallStatus: RECRUITING date: 2023-08-09 date: 2024-05-15 date: 2025-08-09 date: 2024-03-15 date: 2024-03-15 name: Oklahoma State University class: OTHER briefSummary: The goal of this clinical trial is to learn about, test, and compare health outcomes of high vs. low-processed feeding. The main question\[s\] it aims to answer are:
If there is a comparison group: Researchers will compare the low-processed group to the typical diet group to see if there are improvements in metabolic health. conditions: Healthy Nutrition studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: Low-Processed Food Diet measure: Body Weight measure: Body Composition measure: Fat Mass Percentage measure: Fat-Free Mass Percentage measure: Triglyceride Levels measure: Glucose Levels measure: Cholesterol Levels measure: HDL measure: LDL measure: Alanine transaminase (ALT) measure: Aspartate transaminase (AST) measure: Energy Intake measure: Energy Expenditure measure: Gut Microbiome Collection sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Laboratory for Applied Nutrition and Exercise Science (LANES) status: RECRUITING city: Stillwater state: Oklahoma zip: 74075 country: United States name: Sam Emerson, PhD role: CONTACT email: sam.emerson@okstate.edu name: Tyler Godsey, B.S. role: CONTACT phone: 405-744-7708 email: tylgods@okstate.edu name: Sam Emerson, PhD role: PRINCIPAL_INVESTIGATOR lat: 36.11561 lon: -97.05837 hasResults: False
nctId: NCT06310577 id: EH23-343 briefTitle: Evaluation of Leak-Free Bronchoscope Adapter to Limit Ventilated Air Volume Loss During Bronchoscopy overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-11 date: 2026-11 date: 2024-03-15 date: 2024-03-15 name: NorthShore University HealthSystem class: OTHER briefSummary: The purpose of this research is to evaluate the ability of a new bronchoscope adapter called "leak-free adapter" to limit the amount of air leaking out to the operating room (OR) from the ventilator in intubated patients who undergo bronchoscopy. conditions: Pulmonary Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Self-controlled primaryPurpose: TREATMENT masking: NONE count: 44 type: ESTIMATED name: Leak-free bronchoscope adapter measure: Number of participants able to undergo bronchoscopic evaluation using the "leak-free adapter" measure: Heart rate (bpm) measure: Blood pressure (mmHg) measure: Oxygenation as measured by SpO2 measure: Assessment of adverse events measure: Evaluation of bronchoscope adapter tidal volume loss efficacy measure: Evaluation of bronchoscope adapter aerosolization efficacy measure: Peak airway pressure (cmH2O) measure: Dynamic compliance (mL/CmH2O) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06310564 id: 2023-18 briefTitle: Low and Intermediate Risk oliGometastatic coloREctal cancEr patieNts Treated With Stereotactic ABlative Radiotherapy acronym: GREENLaIT-SABR overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2031-04 date: 2031-04 date: 2024-03-15 date: 2024-03-15 name: IRCCS Sacro Cuore Don Calabria di Negrar class: OTHER briefSummary: This is an experimental study without drug or device, randomized, open-label, non-profit, sponsored by the IRCCS Sacro Cuore Don Calabria Hospital in Negrar, which will take place at the Department of Advanced Oncological Radiotherapy and 18 other Italian centers.
It is hoped that the addition of this type of radiotherapy will increase the potential clinical benefit of the treatment in the context of colorectal cancer. conditions: Colorectal Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 204 type: ESTIMATED name: SABR measure: Progression-free survival (PFS). measure: Time to the polymetastatic conversion (tPMC) measure: Local control (LC): the time between randomization to the date of radiological development of local progression after SABR. measure: Overall survival (OS) measure: Time to start of the next systemic treatment line (NEST) measure: Number of adverse events as assessed by CTCAE v4.0 measure: Number of acute side-effects measure: Number of Late side-effects measure: questionnaire QLQ-C30 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Sacro Cuore Don Calabria di Negrar city: Negrar state: Verona zip: 37024 country: Italy name: Luca Nicosia, Doctor role: CONTACT phone: +39(0)456014800 email: luca.nicosia@sacrocuore.it lat: 45.52918 lon: 10.93899 hasResults: False
nctId: NCT06310538 id: 2024BZYLL0110 briefTitle: Clinical Study on the Treatment of Breast Hyperplasia With Kou Sha Therapy Based on Real World overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-05 date: 2024-05 date: 2024-03-15 date: 2024-03-15 name: Hongguo Rong class: OTHER briefSummary: In this study, epidemiological prospective real-world cohort study design was adopted. The Third Affiliated Hospital of Beijing University of Chinese Medicine and the First Hospital of Handan City, Hebei Province were selected. From the same time appointed before the study, all breast hyperplasia participants who met the admission criteria choosing Kou Sha therapy or routine treatment of western medicine were selected in the sample hospitals.The first 30 participants were included in the planned Kou Sha therapy group while the first 30 participants were included in the control group.Taking the change of the total score of breast pain (McGill Pain Questionnaire Short Form score+breast pain score) as the main curative effect index, and taking McGill pain questionnaire score, breast color ultrasound score, palpation lump score, quality of life, anxiety and depression symptoms, sleep and so on as the secondary curative effect indexes to observe the clinical effect of the method of Kou Sha therapy on breast hyperplasia. The research period is from March 2024 to May 2024. conditions: Breast Hyperplasia studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: kou sha name: Hongjin Xiaojie Capsules measure: Breast pain score measure: Short Form McGill Pain Inquiry Scale (SF-MPQ) measure: Breast color ultrasound score measure: Palpation lump score measure: Depression symptoms measure: Anxiety symptoms measure: The quality of life rating scale (QOL) sex: FEMALE minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT hasResults: False
nctId: NCT06310525 id: DROWN_DDF2 briefTitle: Using Machine Learning to Optimise the Danish Drowning Formula acronym: DROWN_DDF2 overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-01 date: 2024-12-31 date: 2024-12-31 date: 2024-03-15 date: 2024-03-25 name: Prehospital Center, Region Zealand class: OTHER briefSummary: The Danish Drowning Formula (DDF) was designed to search the unstructured text fields in the Danish nationwide Prehospital Electronic Medical Record on unrestricted terms with comprehensive search criteria to identify all potential water-related incidents and achieve a high sensitivity. This was important as drowning is a rare occurrence, but it resulted in a low Positive Predictive Value for detecting drowning incidents specifically. This study aims to augment the positive predictive value of the DDF and reduce the temporal demands associated with manual validation. conditions: Drowning conditions: Drowning and Submersion While in Bath-Tub conditions: Drowning and Submersion While in Natural Water conditions: Drowning and Submersion While in Swimming-Pool conditions: Drowning and Submersion Due to Fall Off Ship conditions: Drowning and Nonfatal Submersion conditions: Drowning, Near conditions: Drowning; Asphyxia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 1500 type: ESTIMATED name: Drowning incident measure: Sensitivity of the machine learning algorithm as a drowning identification tool measure: Specificity of the machine learning algorithm as a drowning identification tool measure: PPV of the machine learning algorithm measure: NPV of the machine learning algorithm sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Prehospital Center city: Næstved state: Region Zealand zip: 4700 country: Denmark lat: 55.22992 lon: 11.76092 hasResults: False
nctId: NCT06310512 id: ANZHEN HOSPITOL-LY-04 briefTitle: Efficacy of Pharmacist Interventions Through the "Medication Therapy Management Pathway in Hypertensive Patients" acronym: PharmMTMH overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-31 date: 2026-06-30 date: 2024-03-15 date: 2024-03-15 name: Beijing Anzhen Hospital class: OTHER briefSummary: The goal of this Randomized Controlled Trial is to carry out in adult patients with primary hypertension whose blood pressure control is not up to standard. The main question it aims to answer are:
Researchers will compare the non intervention group to see if patients' blood pressure will also be reduced without intervention. conditions: Hypertension conditions: Medication Therapy Management studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 420 type: ESTIMATED name: Structured drug therapy management measure: systolic blood pressure measure: diastolic blood pressure measure: Change from baseline in mean sitting systolic blood pressure at 3 months measure: Change from baseline in number of medication-related problems (MRP) at 6 months measure: Average number of medication-related problems (MRP) resolved after 6 months measure: The compliance rate of blood pressure after 6 months measure: Effective rate of blood pressure lowering after 6 months measure: Time to BP Attainment in Intervention and Non-Intervention Groups measure: Changes from baseline in adherence scores at 6 months,the General Medication Compliance Scale (GMAS) was used. measure: Economic indicators，mainly including the cost of implementing intervention measures and the impact of intervention measures on patient diagnosis and treatment costs sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beijing Anzhen Hospital city: Beijing state: Beijing zip: 100029 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06310499 id: DROWN_COD briefTitle: Primary or Secondary Drowning acronym: DROWN_COD overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2025-12-31 date: 2025-12-31 date: 2024-03-15 date: 2024-03-15 name: Prehospital Center, Region Zealand class: OTHER briefSummary: According to WHO's rules, any death certificate must state the underlying cause of death and contributory causes of death may also be stated.
Differentiating between primary and secondary drowning is difficult, as information preceding the drowning incident is rarely available. Yet, knowing the most frequent causes of secondary drowning may provide useful information to healthcare professionals working in prehospital Emergency Medical Services, as this may affect prehospital treatment. conditions: Drowning conditions: Drowning; Anoxia conditions: Drowning, Near conditions: Drowning in Swimming Pool conditions: Drowning; Asphyxia conditions: Drowning/Diving/SCUBA Accident conditions: Drowning or Immersion of Unknown Intent conditions: Drowning and Submersion, Undetermined Intent conditions: Drowning and Submersion While in Bath-Tub conditions: Drowning and Submersion While in Natural Water conditions: Drowning and Submersion Due to Sailboat Sinking conditions: Drowning and Submersion Due to Fall Off Ship conditions: Drowning and Submersion While in Swimming-Pool studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 700 type: ESTIMATED name: Drowning measure: Autopsy rate measure: Primary fatal drowning rate measure: Secondary fatal drowning rate sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Prehospital Center city: Næstved state: Region Zealand zip: 4700 country: Denmark lat: 55.22992 lon: 11.76092 hasResults: False
nctId: NCT06310486 id: DROWN_CALL briefTitle: The Emergency Call on Drowning acronym: DROWN_CALL overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-31 date: 2025-12-31 date: 2024-03-15 date: 2024-03-15 name: Prehospital Center, Region Zealand class: OTHER briefSummary: This study aims to 1) describe patient-, setting-, and dispatcher-related characteristics in drowning-related emergency calls to the Emergency Medical Dispatch Centre (1-1-2 emergency phone) and 2) factors associated with 30-day survival. The investigators will separately analyse drowning-related out-of-hospital cardiac arrest (OHCA) and drowning-related non-OHCA. If feasible, the investigators will qualitatively analyse the calls to identify and describe potential barriers for an optimal handling strategy. conditions: Drowning conditions: Drowning; Anoxia conditions: Drowning, Near conditions: Drowning; Asphyxia conditions: Drowning and Nonfatal Submersion conditions: Drowning or Immersion of Unknown Intent conditions: Drowning and Submersion, Undetermined Intent conditions: Drowning and Submersion While in Bath-Tub conditions: Drowning and Submersion While in Natural Water conditions: Drowning and Submersion Due to Sailboat Sinking conditions: Drowning and Submersion Due to Fall Off Ship conditions: Drowning and Submersion While in Swimming-Pool studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 1500 type: ESTIMATED name: Drowning-related OHCA name: Drowning-related non-OHCA measure: Patient-related characteristics influencing the 30-day survival measure: Setting-related characteristics influencing the 30-day survival measure: Caller-related characteristics influencing the 30-day survival measure: Dispatcher-related characteristics influencing the 30-day survival sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Prehospital Center city: Næstved state: Region Zealand zip: 4700 country: Denmark lat: 55.22992 lon: 11.76092 hasResults: False
nctId: NCT06310473 id: NFEC-2023-582 briefTitle: Neoadjuvant Cadonilimab Plus Chemotherapy for Locally Advanced Esophagogastric Junction and Gastric Cancer Trial overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-03 date: 2028-03 date: 2024-03-15 date: 2024-03-15 name: Nanfang Hospital, Southern Medical University class: OTHER briefSummary: For locally advanced esophagogastric junction and gastric cancer, neoadjuvant chemotherapy can downstage T and N stage,treated distant micrometastases early , and finally improve the long-term survival. Combination of perioperative PD-1 antibody and chemotherapy for locally advanced esophagogastric junction and gastric cancer could be a novel therapy to increase response rate and reduce recurrence rate.Cadonilimab, a tetravalent bispecific antibody targeting PD-1 and CTLA-4, is designed to retain the efficacy benefit of combination of PD-1 and CTLA-4 and improve on the safety profile of the combination therapy. The aim of this study is to evaluate the efficacy and safety of cadonilimab Plus Chemotherapy for Locally Advanced Esophagogastric Junction and Gastric Cancer. conditions: Gastric Cancer conditions: Esophagogastric Junction Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Cadonilimab name: Oxaliplatin name: Capecitabine measure: Pathologic complete remission rate (pCR) measure: Major pathologic response，MPR measure: R0 resection rate measure: Objective Response Rate (ORR) measure: Disease Control Rate (DCR) measure: 3-year disease-free survival rate of 3year (DFS) measure: Overall Survival (OS) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Nanfang Hospital, Southern Medical University city: Guangzhou state: Guangdong zip: 510-515 country: China name: Guoxin Li, M.D., Ph.D. role: CONTACT phone: +86-138-0277-1450 email: gzliguoxin@163.com name: Guoxin Li, M.D., Ph.D. role: PRINCIPAL_INVESTIGATOR name: Liying Zhao, M.D., Ph.D. role: SUB_INVESTIGATOR lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06310460 id: PCP briefTitle: Evaluation of "PreCut-Papillectomy" in Difficult Biliary Cannulation overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2025-02-28 date: 2024-03-15 date: 2024-03-15 name: Kliniken Ludwigsburg-Bietigheim gGmbH class: OTHER briefSummary: To evaluate the effectiveness and sefety of papillectomy to enable bile duct access during endoscopic retrograde cholangiography in patients with difficult biliary cannulation. conditions: Cholangiopancreatography, Endoscopic Retrograde studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED name: Papillectomy measure: Rate of treatment success measure: Adverse event rate sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06310447 id: IstanbulBUFC2 briefTitle: Determination of Ecological Awareness and Attitudes Levels of Undergraduate Physiotherapy Students in Istanbul overallStatus: COMPLETED date: 2024-03-18 date: 2024-04-01 date: 2024-04-03 date: 2024-03-15 date: 2024-04-04 name: Istanbul Bilgi University class: OTHER briefSummary: The natural environment, which is the living environment of all living things; Technological advances and industrialization activities are being affected more and more negatively every day. Increasing energy demand and resource consumption due to population growth lead to negative consequences on ecological balance, such as environmental pollution, climate change and loss of natural environments. Health services have also increased resource use with the advancement of technology and caused negative effects on the environment. Health services have been slow to understand their impact on the environment. The aim of the study is to determine the environmental awareness and environmental attitude levels of physiotherapy and rehabilitation department students, to popularize the field of "Environmental Physiotherapy" and to enable the training of physiotherapist candidates with high environmental awareness. conditions: Ecological and Environmental Concepts studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 151 type: ACTUAL measure: Ecological Footprint Awareness Scale measure: Environmental Awareness Scale measure: Environmental Attitude Scale measure: Participant Information Form sex: ALL minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Istanbul Bilgi University city: Istanbul zip: 34440 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False