nctId: NCT06282718 id: POS-ARI-PC CORE and AUDIT id: 965313 type: OTHER_GRANT domain: European Union id: 10204126 type: REGISTRY domain: ISRCTN id: 55487 type: OTHER domain: NIHR CPMS id: 324504 type: OTHER domain: IRAS briefTitle: A Long-term Observational Study Evaluating the Presentation and Management of Acute Respiratory Tract Infections in Primary Care Across Europe acronym: POS-ARI-PC overallStatus: NOT_YET_RECRUITING date: 2024-02 date: 2026-03 date: 2026-03 date: 2024-02-28 date: 2024-02-28 name: European Clinical Research Alliance for Infectious Diseases (ECRAID) class: OTHER name: UMC Utrecht name: University of Oxford name: Universiteit Antwerpen briefSummary: Acute respiratory infection (ARI) is the commonest reason for consulting in community care. Furthermore, new and re-emerging pathogens are often first noticed in primary care (PC). The POS-ARI-PC study is a long-term study, with the aim of describing the nature of ARI in adults and children presenting to PC across Europe. The POS-ARI-PC study will provide critically important data on the presentation and management of ARI, and build a research-ready infrastructure for studies related to the treatment, diagnosis, and prevention of ARI in primary care settings. Additional observational studies will be embedded and use the infrastructure developed in POS-ARI-PC. conditions: Acute Respiratory Tract Infection studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2000 type: ESTIMATED measure: Age Bands measure: The proportion with a preliminary diagnosis of various sub-categories of ARI (e.g. LRTI, URTI) measure: Overall illness severity rating measure: Swab samples taken and retrospective viral/microbiological infection analysis performed (multiplex PCR) to identify potential causative pathogens. measure: Proportion undergoing POC (with results) and lab-based investigations measure: Details of prescriptions given on presentation of ARI measure: Details of tests ordered on presentation of ARI measure: Return to usual daily activities measure: Feeling recovered from RTI measure: Use of prescription medication measure: Use of over the counter medications measure: Complications reported associated to ARI presentation measure: Variation in practice and advice from national guidelines, to be fed back to national teams measure: Recommendations on how to improve study processes, recruitment and study communication based on shared understanding and insights from researchers, clinicians, and patients. measure: An understanding of the meaning of study results for European primary care, from the perspectives of clinicians and patients, and recommendations regarding the implementation of findings. measure: An understanding of changing health-seeking behaviour, management and expectations to inform clinical studies and trials measure: Approval for a study-specific appendix (SSA) or an intervention-specific appendix (ISA) of an embedded (non) randomised study for ARI in primary care associated with this POS, measured using the number of embedded studies to this POS-ARI-PC platform over sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False