nctId: NCT06267521 id: 2023-1473 id: Protocol Version 2/8/2024 type: OTHER domain: UW Madison id: L&S/PSYCHOLOGY/PSYCHOLOGY type: OTHER domain: UW Madison id: A487400 type: OTHER domain: UW Madison id: AWD00000302 type: OTHER_GRANT domain: US Department of Defense DARPA briefTitle: The STRENGTHEN Study overallStatus: RECRUITING date: 2024-03-06 date: 2025-02 date: 2025-02 date: 2024-02-20 date: 2024-03-27 name: University of Wisconsin, Madison class: OTHER name: United States Department of Defense briefSummary: This study uses two different types of interventions including electrical brain stimulation delivered during sleep, and brief, daily meditation training. The investigators are trying to figure out whether these techniques, either alone or in combination with each other, can positively impact the brain networks that support our ability to think flexibly and to regulate our emotions. 48 participants will be enrolled and can expect to be on study for up to 9 months. conditions: Cognitive Flexibility conditions: Emotional Regulation studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: SINGLE maskingDescription: Participants will not know whether they are in a group receiving active stimulation (groups 2, 3, and 4) or sham stimulation (group 1). However, participants will know whether they are performing meditation (groups 1, 3, and 4) or listening to only the didactic meditation material (group 2), and participants will be aware of how many nights they are undergoing stimulation (1 night per week for group 3, 2 nights per week for groups 1, 2, and 4). Thus, participants will be only partially blind to condition. Investigators will not be blind to condition. whoMasked: PARTICIPANT count: 48 type: ESTIMATED name: Healthy Minds Program name: Sham Meditation Didactic Material name: Sham Stimulation in Lab name: Stimulation in Lab name: MRI Scanner measure: Change in Patient Health Questionnaire-9 (PHQ-9) Score measure: Change in General Anxiety Disorder (GAD-7) Score measure: Change in Single-item Suicide Question measure: Change in Healthy Minds Index (HM Index) measure: Change in the Perceived Stress Scale (PSS) Score measure: Change in Emotional Styles Questionnaire (ESQ) Score measure: Change in Cognitive Flexibility Inventory (CFI) Score: Alternatives Subscale measure: Change in Cognitive Flexibility Inventory (CFI) Score: Control Subscale measure: Change in Difficulties in Emotion Regulation Scale-18 (DERS-18) Score measure: Change in PROMIS Sleep Disturbance Score measure: Change in PTSD Checklist for DSM-5 (PCL-5) measure: Change in World Health Organization-5 (WHO-5) measure: Change in Restorative Sleep Questionnaire (RSQ) Score measure: Change in Sleep Depth Question (SDQ) Score measure: Change in Pittsburgh Sleep Quality Index (PSQI) Score measure: Change in Suicide Risk Survey measure: Change in Brief Suicide Cognitions Scale (B-SCS) Score measure: Change in Passive and Active Suicidal Ideation Scale (PASIS) Score measure: Change in NIH Toolbox Loneliness Score measure: Change in Five Facet Mindfulness Questionnaire (FFMQ) Score measure: Change in Drexel Defusion Scale (DDS) Score measure: Change in PROMIS Meaning and Purpose Score measure: Change in Digital Working Alliance Inventory (D-WAI) Score measure: Change in Perseverative Thinking Questionnaire (PTQ) Score measure: Change in Experiences Questionnaire's Decentering subscale (EQ-D) Score measure: Change in Experience Sampling / Ecological Momentary Assessment measure: Change in Death Implicit Association Test Score measure: Change in Reversal Learning Task Score measure: Change in Multi-Source Interference Task Score measure: Change in Emotional Stroop Score: Reaction Time measure: Change in Emotional Stroop Score: Percent Correct measure: Change in Meteor Mission Score: Mean Reaction Time measure: Change in Meteor Mission Score: Coefficient of Variation measure: Change in Meteor Mission Score: Percent Correct measure: Change in Emotional Persistence Task Score measure: Change in Change Your Mind Task Score: Mean Change measure: Change in Change Your Mind Task Score: Accuracy measure: Change in Change Your Mind Task Score: Response Time measure: Change in Spectral Power Density During Stimulation-Free Sleep measure: Resting-state fMRI Connectivity Z-Scores sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Center for Healthy Minds status: RECRUITING city: Madison state: Wisconsin zip: 53703 country: United States lat: 43.07305 lon: -89.40123 hasResults: False