hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06273774 id: 8189-020 id: MK-8189-020 type: OTHER domain: Merck briefTitle: A Study of MK-8189 in Participants With Bipolar I Disorder (MK-8189-020) overallStatus: RECRUITING date: 2024-04-08 date: 2024-09-10 date: 2024-09-10 date: 2024-02-23 date: 2024-04-23 name: Merck Sharp & Dohme LLC class: INDUSTRY briefSummary: The goal of this study is to evaluate the safety and tolerability of MK-8189 in participants with stable bipolar I disorder. There will be no hypothesis testing in this study. conditions: Bipolar I Disorder studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 32 type: ESTIMATED name: MK-8189 name: Placebo measure: Number of Participants Who Experience One or More Adverse Events (AEs) measure: Number of Participants Who Discontinue Study Treatment Due to an AE sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Hassman Research Institute Marlton Site ( Site 0006) status: RECRUITING city: Marlton state: New Jersey zip: 08053 country: United States name: Study Coordinator role: CONTACT phone: 267-981-8911 lat: 39.89122 lon: -74.92183 hasResults: False
nctId: NCT06273761 id: UW 23-550 briefTitle: Evaluation of Medication Management Service overallStatus: RECRUITING date: 2024-02-06 date: 2026-08-01 date: 2027-05-01 date: 2024-02-23 date: 2024-02-23 name: The University of Hong Kong class: OTHER name: Hong Kong Jockey Club Charities Trust name: Hong Kong Sheng Kung Hui Welfare Council name: Hong Kong Young Women's Christian Association name: Haven of Hope Hospital name: Pok Oi Hospital name: St. James Settlement name: Aberdeen Kai-fong Welfare Association name: Health In Action name: Lok Sin Tong Benevolent Society, Kowloon briefSummary: Medication management services (MMS) is a pharmacist-led service of optimizing the medication use and health outcomes, by promoting medication safety and enhancing the ability in self-management of health and diseases of patients and their caregivers. Yet, only limited evidence on the implementation of MMS service in Hong Kong is available. The goal of this clinical trial is to evaluate the cost effectiveness and effects of implementing MMS in community pharmacies owned by 8 non-government organizations (NGOs) in Hong Kong on humanistic and clinical outcomes in patients with hypertension and/or type II diabetes mellitus. The clinical trial aims to look into the following aspects:
nctId: NCT06273735 id: 2019-PS-33b id: PV7350 type: OTHER domain: Martini-Klinik briefTitle: Prospective Trial: Myocardial Injury After Noncardiac Surgery (MINS) Following Radical Prostatectomy overallStatus: RECRUITING date: 2023-08-14 date: 2024-03 date: 2026-10 date: 2024-02-22 date: 2024-02-22 name: Martini-Klinik am UKE GmbH class: OTHER name: Universitätsklinikum Hamburg-Eppendorf briefSummary: The aim of this study is to prospectively analyse the rate of MINS in the standardised radical prostatectomy patient clientele at the Martini-Clinic and to identify risk factors. Pre- and postoperative troponin levels are determined (1st and 2nd postoperative day). The patient's height, weight, age and cardiovascular risk factors (including determination of the Revised Cardiac Risk Index) are recorded in the medical history as well as previous medical and interventional cardiological therapy. Furthermore, the prostate carcinoma-associated tumour and surgical parameters are determined. Clinically significant cardiovascular events during the inpatient stay are also described. Finally, a description of the rate of events, a check for correlation with the Revised Cardiac Risk Index and an identification of risk factors are carried out. conditions: Myocardial Injury studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: Pre- and postoperative determination of troponin as part of the study and 24-month FU survey measure: rate of MINS in standardised open and robot-assisted radical prostatectomy sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Martini-Klinik am UKE GmbH status: RECRUITING city: Hamburg zip: 20246 country: Germany name: Markus Graefen, Professor role: CONTACT phone: +4904741051300 email: graefen@uke.de name: Anke Renter role: CONTACT phone: +49407410533115 email: renter@uke.de lat: 53.57532 lon: 10.01534 hasResults: False
nctId: NCT06273722 id: 2024-0059 briefTitle: D-OCT for Detection and Subtyping of BCC: a Diagnostic Cohort Study overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-07-01 date: 2024-12-31 date: 2024-02-22 date: 2024-02-22 name: Maastricht University Medical Center class: OTHER briefSummary: The current gold standard for diagnosing basal cell carcinoma (BCC) is the histopathological examination of biopsy specimen. However, non-invasive imaging modalities such as optical coherence tomography (OCT) may replace biopsy if BCC presence and its subtype can be established with high confidence. Subtype differentiation is crucial; while superficial BCCs (sBCC) can be treated topically, nodular (nBCC) and infiltrative BCCs (iBCC) require excision. Dynamic OCT (D-OCT) is a functionality integrated within the OCT device, enabling the visualization of vascular structures through speckle variance.
Descriptive studies have unveiled vascular shapes and patterns associated with BCC and its respective subtypes. These findings suggest that D-OCT could contribute to the accuracy of BCC detection and subtyping. Yet comparative clinical studies between OCT and D-OCT are lacking. In the proposed diagnostic cohort study, we aim to assess whether D-OCT assessment is superior to OCT in terms of accuracy for BCC detection and subtyping. conditions: Basal Cell Carcinoma conditions: Optical Coherence Tomography studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 424 type: ESTIMATED name: Vivosight Multi-beam Swept-Source Frequency Domain OCT scanner measure: Diagnostic accuracy for BCC detection on D-OCT assessment measure: Diagnostic accuracy for BCC subtyping on D-OCT assessment measure: Diagnostic value of vascular structures and patterns sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06273709 id: 2023-3698 briefTitle: Remote Assessment of OCT Scans for BCC Detection overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-07-01 date: 2024-12-31 date: 2024-02-22 date: 2024-02-22 name: Maastricht University Medical Center class: OTHER briefSummary: Basal cell carcinoma (BCC) is the most common form of cancer and entails approximately 80% of all cutaneous malignancies. This locally destructive neoplasm is commonly diagnosed by punch biopsy which is considered painful, causes procedural scarring and carries a small risk of infection and re-bleeding associated with invasive procedures. Moreover, awaiting the results of the subsequent histopathological examination causes treatment delay and can be stressful for the patient. The drawbacks of biopsy could be overcome by optical coherence tomography (OCT), a non-invasive diagnostic modality that may replace biopsy in up to 66% of patients. However, OCT assessors are scarce which hinders the implementation of OCT. This problem may be addressed by teledermatology in which remote OCT assessment by an assessor facilitates simultaneous assessment for multiple clinics. Remote OCT assessment withholds the OCT assessor from visually inspecting the lesion. But the effect of visual inspection on the diagnostic accuracy remains unknown and the question arises whether visual inspection is necessary for accurate OCT assessment. In this diagnostic case-control study we will determine whether distant OCT assessment without visual information on the lesion is non-inferior to distant OCT assessment with clinical and dermoscopic photographs (CDP-OCT). conditions: Basal Cell Carcinoma studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 120 type: ESTIMATED name: Vivosight Multi-beam Swept-Source Frequency Domain OCT scanner measure: Diagnostic accuracy of high-confidence BCC diagnosis with and without clinical/dermoscopic photographs sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06273696 id: 2019-519 id: NU2GGH001927 type: OTHER_GRANT domain: Centers for Disease Control and Prevention briefTitle: Evaluation of the Acceptability and Safety of the ShangRing Device for Male Circumcision in Shinyanga, Tanzania overallStatus: COMPLETED date: 2019-05-01 date: 2019-06-11 date: 2019-07-30 date: 2024-02-22 date: 2024-02-22 name: IntraHealth International class: OTHER name: Ministry of Health, Tanzania name: President Office Regional Administration and Local Government, Tanzania name: Centers for Disease Control and Prevention name: Jhpiego name: World Health Organization briefSummary: The goal of this observational study was to evaluate the safety and acceptability of the ShangRing device for male circumcision among men in Shinyanga, Tanzania. The main question aims to answer both provider acceptability (practicality of device use and placement and removal times) and client acceptability (comfort during placement and removal, experience while wearing the ring, and penile appearance after healing). Participants voluntarily underwent male circumcision using the ShangRing device and before being discharged, were interviewed about their experience. Participants were also interviewed at device removal day (day 7), during a follow-up phone call (day 10), a sample were selected to participate in in-depth interviews (day28), and finally all men were asked to return for a follow-up visit (day 49). conditions: Penile Infection conditions: Penile Haematoma conditions: Penile Bleeding conditions: Deformity studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 575 type: ACTUAL name: ShangRing measure: Number of Adverse Events measure: Number of Clients with Adverse Events measure: Descriptions of Adverse Events measure: Provider Training measure: Client Follow-up Visit Rate measure: Client Preference for ShangRing Over Surgical Circumcision measure: Client Recommendation Rate measure: Cosmetic Result Acceptability measure: Client Experience While Performing Routine Activities measure: Client Discomfort measure: Provider Ease of Application measure: Provider Preference measure: Provider Recommendation measure: Description of Procedures measure: Healing rate sex: MALE minimumAge: 13 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Kahama District Hospital city: Shinyanga country: Tanzania lat: -3.66393 lon: 33.42118 facility: Ushetu Health Centre city: Shinyanga country: Tanzania lat: -3.66393 lon: 33.42118 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2018-10-22 uploadDate: 2024-02-14T09:36 filename: Prot_000.pdf size: 2701616 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2018-07-01 uploadDate: 2023-01-18T15:12 filename: ICF_001.pdf size: 173615 hasResults: False
nctId: NCT06273683 id: INOVA-2023-145 briefTitle: Comparison of Two Salpingectomy Techniques for Sterilization at the Time of Cesarean Delivery overallStatus: RECRUITING date: 2024-03-11 date: 2024-12 date: 2024-12 date: 2024-02-22 date: 2024-03-20 name: Inova Health Care Services class: OTHER briefSummary: One in three women of reproductive age utilize tubal sterilization for contraception, and sterilization is often requested at time of cesarean delivery. Complete salpingectomy for the purpose of permanent sterilization at the time of cesarean birth is increasingly being performed worldwide.
A preferred complete salpingectomy technique for the purpose of sterilization at the time of cesarean delivery has not emerged in current practice. The objective is to compare short-term clinical outcomes and cost of salpingectomy using a hand-held bipolar energy instrument with those of traditional suture ligation. This retrospective cohort study will be conducted from 2017-2023 at a single tertiary care hospital. The investigators hypothesize that bipolar energy instrument use will not significantly improve clinical outcomes. conditions: Permanent Sterilization conditions: Pregnancy Related studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 900 type: ESTIMATED name: Hand-held bipolar energy instrument name: Traditional suture ligation measure: Change in Hemoglobin levels on postoperative day one measure: Completion rate of sterilization measure: Total procedure estimated blood loss measure: Adjacent organ damage measure: Need for blood transfusion measure: Total operative time measure: ICU admission measure: Length of hospital stay measure: Hospital readmission postoperatively measure: Reoperation rates measure: Pain score measure: Surgical site infection measure: Cost sex: FEMALE minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Inova Fairfax Medical campus status: RECRUITING city: Falls Church state: Virginia zip: 22042 country: United States name: Jean W Thermolice, MD role: CONTACT phone: 703-531-3000 email: jean.thermolice@inova.org name: Bianca Nguyen, MD role: CONTACT email: bianca.nguyen@inova.org name: Sofia Girald-Berlingeri, MD role: SUB_INVESTIGATOR name: Bianca Nguyen, MD role: SUB_INVESTIGATOR name: Catherine Kim, MD role: SUB_INVESTIGATOR name: Miranda Newell, MS role: SUB_INVESTIGATOR name: Renee Brenner, BS role: SUB_INVESTIGATOR lat: 38.88233 lon: -77.17109 hasResults: False
nctId: NCT06273670 id: 04-2023-200279 briefTitle: Postpartum Initiation of Long-acting Reversible Contraceptives: Knowledge Attitude and Practice Study (KAP) acronym: KAP overallStatus: RECRUITING date: 2023-06-15 date: 2024-12 date: 2025-10 date: 2024-02-22 date: 2024-02-22 name: Assiut University class: OTHER briefSummary: Comparing Knowledge, attitude and Practice of clients and service providers about the regular (6 weeks) versus earlier initiation of LARC, through a structured questionnaire prepared in English and translated to local language i.e. Arabic. conditions: Contraception studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 600 type: ESTIMATED name: screening and data collection measure: Clients' knowledge measure: Clients' attitude measure: Clients' practice measure: Providers' knowledge measure: Providers' attitude measure: Providers' practice sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Assiut University status: RECRUITING city: Assiut zip: 71515 country: Egypt name: mahmoud abdelaleem, Doctorate role: CONTACT phone: +201018880201 email: mahmaleem2000@yahoo.co.uk lat: 27.18096 lon: 31.18368 hasResults: False
nctId: NCT06273644 id: HNF1719-24 briefTitle: Clinical Research on Acute Intermittent Porphyria and the Use of Carbohydrate-Rich Diet as a Treatment overallStatus: RECRUITING date: 2024-01-27 date: 2027-10-31 date: 2037-12-31 date: 2024-02-22 date: 2024-02-22 name: Nordlandssykehuset HF class: OTHER name: University of Oslo name: Nord University name: UiT The Arctic University of Norway name: Norwegian University of Science and Technology name: The University of Texas Medical Branch, Galveston briefSummary: The main aim of this clinical trial is to learn about the effect of carbohydrate-rich diet as a treatment for AIP (acute intermittent porphyria).
nctId: NCT06273631 id: 2022-SR-481 briefTitle: Effect of Changes in Carbohydrate Intake on Glucose Control in Patients With Type 1 Diabetes overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2025-12-31 date: 2024-02-22 date: 2024-02-22 name: Yang Tao class: OTHER briefSummary: The blood glucose fluctuates greatly in T1DM patients, especially in the middle and late stages of the disease, and carbohydrate (CHO) is the main determinant of postprandial glucose response (PGR). Based on the previous investigation to understand how nutritional habits affect blood glucose control, we will conduct dietary intervention studies in T1DM patients to explore whether the adjustment of dietary pattern is beneficial to blood glucose control, and further explore the relevant mechanism through the detection of related metabolic indicators. conditions: Type 1 Diabetes conditions: Diet Intervention conditions: Glucose Control studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 78 type: ESTIMATED name: multiple-diverse carbohydrate diet name: middle carbohydrate diet measure: Change of time in range (TIR) measure: Change of coefficient of variation of blood glucose（CV） measure: Change of mean amplitude of glycemic excursions（MAGE） measure: Change in large amplitude of glycemic excursions (LAGE) from baseline measure: Change in GA（glycosylated albumin）from baseline measure: Change in HbA1c from baseline measure: Change in 1,5-anhydroglucitol (1,5-AG) from baseline measure: Change in time above range(TAR) from baseline measure: Change in time below range(TBR) from baseline measure: Change in total insulin dose from baseline measure: Change in blood lipids from baseline measure: Change in body weight from baseline measure: Change in Incidence of hypoglycemic events from baseline measure: Change in gut microbiota from baseline measure: Change in metabolomics from baseline measure: Change in autoimmunity from baseline sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06273618 id: iLO-ML-23396 briefTitle: iLookOut Micro-learning to Improve Knowledge Retention overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2027-02 date: 2027-02 date: 2024-02-22 date: 2024-03-25 name: Milton S. Hershey Medical Center class: OTHER briefSummary: This project investigates whether a multi-faceted strategy involving iLookOut's evidence-based Core Training plus an innovative follow-up Micro-Learning can promote knowledge retention and change behavior among early childhood professionals (ECPs) with regard to child abuse and its reporting. Additionally, this study will evaluate if non-ECPs experience similar improvements and retention of knowledge and changes in behavior as do ECPs. conditions: Knowledge conditions: Attitudes conditions: Practice studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Early Childhood Professionals (ECPs) will be randomized to 1 of 4 groups, which will differ in terms of when they receive access to Micro-Learning. Non-ECPs will constitute a separate group, which will receive access to Micro-Learning immediately upon completing the Core Training. primaryPurpose: OTHER masking: NONE count: 12000 type: ESTIMATED name: Micro-Learning measure: Change in knowledge about child maltreatment and its reporting as assessed by validated iLookOut knowledge test measure: Change in behavior regarding child maltreatment and its reporting as measured by self-report questionnaire measure: Comparison of early childhood professionals vs. non-early childhood professionals sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Penn State College of Medicine city: Hershey state: Pennsylvania zip: 17033 country: United States lat: 40.28592 lon: -76.65025 hasResults: False
nctId: NCT06273605 id: 102828 briefTitle: The Egg Up Trial - Testing a New Treatment Pathway for Infants With Newly Diagnosed Egg Allergy overallStatus: RECRUITING date: 2024-04-09 date: 2025-08-30 date: 2025-08-30 date: 2024-02-22 date: 2024-04-17 name: Murdoch Childrens Research Institute class: OTHER briefSummary: The goal of this study is to test the safety and feasibility of a change in management approach for infants with newly diagnosed egg allergy. Infants with newly diagnosed egg allergy will have egg introduced via a gradual and graded home based approach known as an "egg ladder" supervised by a dietitian. The main questions this study aims to answer are how safe and feasible are home-based dietitian-led "egg ladders" as a treatment pathway to achieve tolerance of egg for newly diagnosed infants with egg allergy. conditions: Food Allergy conditions: Food Allergy in Infants studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Egg Ladder measure: Number and severity of adverse events related to baked egg ingestion (step 1) while following the home-based egg ladder protocol as collected via parent questionnaire and medical history. measure: Number and severity of adverse events related to ingestion of well cooked egg as an ingredient (step 2) while following the home-based egg ladder protocol as collected via parent questionnaire and medical history. measure: Number and severity of adverse events related ingestion of well cooked whole egg (step 3) while following the home-based egg ladder protocol as collected via parent questionnaire and medical history. measure: Number and severity of adverse events related to ingestion of lightly cooked whole egg (step 4) while following the home-based egg ladder protocol as collected via parent questionnaire and medical history. measure: Number and severity of adverse events related to raw egg ingestion (step 5) while following the home-based egg ladder protocol as collected via parent questionnaire and medical history. measure: Feasibility of the home-based, egg ladder protocol to achieve egg allergy resolution 12 months from egg allergy diagnosis measure: Change from baseline (diagnosis) in parent reported Quality of Life scores using the Food Allergy Quality of Life Questionnaire (FAQLQ-PF) to study completion (12 months from diagnosis) measure: Change from baseline (diagnosis) in parental anxiety scores measured using the Impairment Measure for Parental Food Allergy - Associated Anxiety and Coping Tool (IMPAACT) to study completion (12 months from diagnosis) measure: Heath care costs sex: ALL minimumAge: 4 Months maximumAge: 12 Months stdAges: CHILD facility: Murdoch Children's Research Institute (MCRI) status: RECRUITING city: Melbourne state: Victoria zip: 3052 country: Australia name: Vicki McWilliam, PhD role: CONTACT phone: 0418588953 email: vicki.mcwilliam@rch.org.au name: Kirsten Perrett, MD, PhD role: CONTACT email: kirsten.perrett@rch.org.au lat: -37.814 lon: 144.96332 hasResults: False
nctId: NCT06273592 id: 2023-15558 briefTitle: The Impact of a Plant-based Meat Meal Versus an Animal Meat Meal on Erectile Function in Healthy Men. acronym: Erection 2 overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2026-04 date: 2024-02-22 date: 2024-02-22 name: Montefiore Medical Center class: OTHER name: Beyond Meat briefSummary: The goal of this study is to determine whether erectile function is differentially impacted by a single plant-based meat meal versus a single animal meat meal in healthy men with normal erectile function. conditions: Erectile Dysfunction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Randomized crossover design primaryPurpose: PREVENTION masking: SINGLE maskingDescription: Outcomes assessor will be blinded to randomization group and order of testing. whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: Animal-based meal name: Plant-based meat meal measure: Percent of time with ≥70% erection during overnight sleep after 1 meal measure: Erection events per hour during overnight sleep after 1 meal measure: Tumescence events per hour during overnight sleep after 1 meal. measure: Heart rate measure: Blood pressure sex: MALE minimumAge: 18 Years maximumAge: 32 Years stdAges: ADULT hasResults: False