nctId: NCT06279468 id: I-23PJ2232 briefTitle: Clinical Effectiveness of Intervertebral Disc Release in Treating Lenke 5 Adolescent Idiopathic Scoliosis overallStatus: RECRUITING date: 2024-01-01 date: 2026-06-01 date: 2026-06-01 date: 2024-02-28 date: 2024-02-28 name: Peking Union Medical College Hospital class: OTHER briefSummary: Adolescent idiopathic scoliosis (AIS) poses challenges in achieving optimal three-dimensional correction. While posterior fusion with pedicle screws has shown success, osteotomy techniques, such as Ponte osteotomy, have further improved outcomes. However, residual vertebral rotation remains a concern, impacting long-term complications. Intervertebral disc release (IDR) presents a potential solution to enhance derotation and reduce fusion levels, particularly in Lenke Type 5 AIS. This prospective randomized controlled trial aims to evaluate the clinical effectiveness of IDR in treating Lenke 5 AIS, comparing it to Ponte osteotomy. The study focuses on axial vertebral rotation correction, coronal curve improvement, blood loss, hospital stay, and adverse events. Participants aged 10-18 with Lenke 5 AIS will undergo either IDR or Ponte osteotomy, randomly assigned. Outcome measures include axial rotation correction rate, radiographic parameters, and clinical assessments. A total of 132 participants will be recruited. The IDR technique, through posterior disc removal, presents a promising approach to optimize derotation in Lenke 5 AIS. While offering potential advantages, challenges like limited working space and bleeding risks require careful consideration. The study's findings aim to provide robust clinical evidence, enhancing treatment strategies for Lenke 5 AIS and offering innovative approaches for AIS as a whole. conditions: Adolescent Idiopathic Scoliosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 132 type: ESTIMATED name: intervertebral disc release name: Ponte osteotomy measure: The correction rate of axial rotation of the apex vertebrae measure: Lumbar curve measure: UIV tilt measure: C7-CSVL measure: Lumbar lordosis measure: SVA measure: Radiographic parameters measured by CT scan: LIV and LIV+1 translation measure: LIV tilt measure: The lowest instrumented vertebra disc angle measure: Age measure: Gender measure: Risser grade of the patients at the time of surgery measure: number of fused spinal levels measure: length of operation measure: Scoliosis Research Society-22,SRS-22 score measure: the MOS item short from health survey, SF-36 score measure: EuroQol Five Dimensions Questionnaire, EQ-5D score measure: Perioperative total blood loss measure: Visible blood loss measure: Perioperative transfusion amounts measure: Perioperative transfusion rates measure: Rate of postoperative infection measure: The incidence of nerve damage measure: The incidence of loss of correction sex: ALL minimumAge: 10 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Peking Union Medical College Hospital status: RECRUITING city: Beijing state: Beijing zip: 100035 country: China name: Qianyu Zhuang, Professor role: CONTACT phone: +86 15200838996 email: baizhuosong@126.com lat: 39.9075 lon: 116.39723 hasResults: False