hackint0sh/New-Dataset huggingface dataset:
Participants will be involved in 6 sessions. Session 1 will include the assessment, questionnaires, and training. Session 2 will include just the training. Session 3 will include the assessment and training. Sessions 4-5 will include just the training. Session 6 will include the assessment, questionnaires, and training. conditions: Old Age; Debility conditions: Peripheral Neuropathy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SEQUENTIAL interventionModelDescription: The study will include two groups (older adults and people with peripheral neuropathy) which will be assessed pre- and post-intervention primaryPurpose: OTHER masking: NONE count: 30 type: ESTIMATED name: Protective Arm Balance Response Training measure: Grasp Accuracy measure: In-task falls incidence measure: Electromyography (EMG) of the shoulder muscles measure: Physiological responses (heart rate variability) measure: Physiological responses (electrodermal activity) measure: Activity specific balance confidence scale measure: Stait Trait Anxiety Inventory measure: Subjective Units of Distress Scale measure: Mini Mental State Examination (MMSE) measure: Beck Anxiety Inventory measure: Somatosensation sex: ALL minimumAge: 45 Years maximumAge: 88 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Allied Health Research Building status: RECRUITING city: Baltimore state: Maryland zip: 21201 country: United States name: Kelly P Westlake, PhD role: CONTACT phone: 410-706-5919 email: kwestlake@som.umaryland.edu lat: 39.29038 lon: -76.61219 hasResults: False
nctId: NCT06388421 id: GMS-PH-401 briefTitle: DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD) overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2030-08-01 date: 2030-11-30 date: 2024-04-29 date: 2024-04-29 name: United Therapeutics class: INDUSTRY briefSummary: This is a prospective, non-interventional, multicenter, registry of patients with pulmonary associated with interstitial lung disease (PH-ILD). conditions: Pulmonary Hypertension Due to Lung Diseases and Hypoxia conditions: Pulmonary Hypertension conditions: Interstitial Lung Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: Prospective study assessments measure: Baseline characteristics as described by demographics, medical history, ILD history, PH history, family history (comorbidities), and diagnostic right heart catheterization values measure: Changes in clinical features relating to patients' interstitial lung disease and pulmonary hypertension sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06388408 id: SufMAST briefTitle: Effects of Sufentanil Target Controlled Infusion on Patient State Index Values and Electroencephalographic Spectrum During Total Intravenous Anesthesia With Propofol overallStatus: NOT_YET_RECRUITING date: 2024-05-05 date: 2024-09-15 date: 2024-09-30 date: 2024-04-29 date: 2024-04-29 name: University of Padova class: OTHER briefSummary: Sufentanil Target Controlled infusion (TCI, Gepts model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol TCI (Eleveld model) has not been investigate yet.
Authors aim to investigate its effect on Patient State index (PSi), the power spectrum EEG, the Analgesia Nociception Index (ANI) nad pupillometry values during maintenance durin TIVA-TCI with Propofol and Sufentanil. conditions: Anesthesia Brain Monitor conditions: Sufentanil conditions: Target Controlled Infusion studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 40 type: ESTIMATED measure: Effects of Sufentanil on Patient State index (PSi) during stable Propofol general anesthesia measure: Effects of Sufentanil on Electroencephalogram (EEG) power spectrum during stable Propofol general anesthesia measure: Effects of Sufentanil on Analgesia Nociception Index (ANI) during stable Propofol general anesthesia measure: Analgesia Nociception Index (ANI) values and postoperative pain measure: Patient State Index (PSi) values and postoperative delirium measure: Analgesia Nociception Index (ANi) values and postoperative delirium sex: FEMALE minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Treviso Regional Hospital city: Treviso state: TV zip: 31100 country: Italy lat: 45.66673 lon: 12.2416 hasResults: False
nctId: NCT06388395 id: REC-23-05-12-02-F briefTitle: Clinical Performance of All-on-4 PEEK and Conventional Prostheses overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2027-06-30 date: 2027-08-30 date: 2024-04-29 date: 2024-04-29 name: University of Sharjah class: OTHER briefSummary: The all-on-4 treatment approach for completely edentulous mandible is a proven concept. However, there are still issues regarding the use of metal substructure to support the prostheses such as allergy, metallic taste, and aesthetic. Therefore, other materials such as polyetheretherketone (PEEK) are being tested for its suitability and is showing good potential. However, available evidence is limited regarding its clinical performance. Thus, the aim of this study is to compare clinical performance of all-on-4 treatment concept utilizing PEEK versus conventional metal framework as substructure in fully edentulous mandible. Thirty suitable patients will receive either PEEK or conventional all-on-4 prostheses for fully edentulous mandible. The prostheses will be retained by four implants utilizing the all-on-4 principle. Clinical performance will be assessed during the follow up period of up 3 years concerning screw loosening, material chipping or fracture, wear or staining, prosthesis survival and success, implant survival and success. conditions: Failure, Prosthesis conditions: Dental Prosthesis, Implant-Supported conditions: Survival, Prosthesis conditions: Complete Edentulism conditions: Complication;Prostheses studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two groups will be provided with two types of implant-supported prostheses primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Block randomization will be used to randomly assign participants. The sequences will be concealed in opaque, consecutively numbered envelopes for each block. One envelope will be obtained for each participant, corresponding to the assignment of the protocol (conventional versus PEEK). The outcome assessor will be independent and not involved in any treatment procedure whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Accuracy of full-arch surgical guides name: Survival and complications of the prostheses name: Survival and complications of the implants name: Conventional (metal-resin) implant-supported prosthesis name: PEEK implant-supported prosthesis measure: Accuracy of full-arch surgical guides measure: Survival rate of implants measure: Success rates of the Prostheses measure: Pain level measure: Marginal bone loss measure: Plaque index measure: Pocket depth measure: Bleeding index sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Sharjah city: Sharjah zip: 7724 country: United Arab Emirates lat: 25.33737 lon: 55.41206 hasResults: False
nctId: NCT06388382 id: UKKx2024 briefTitle: Investigation of the Audible ICD Alert Tone overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2025-05-15 date: 2025-05-30 date: 2024-04-29 date: 2024-04-29 name: Universitätsklinikum Köln class: OTHER briefSummary: Ability of ICD patients to hear the audible ICD alert is being assessed. conditions: Implantable Defibrillator User studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 150 type: ESTIMATED name: Alert tone demonstration measure: Alert tone audible sex: ALL minimumAge: 15 Years maximumAge: 100 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Cologne city: Cologne zip: 50937 country: Germany lat: 50.93333 lon: 6.95 hasResults: False
nctId: NCT06388369 id: CA184-608 briefTitle: Neoadjuvant Lu-PSMA Radioligand Therapy and Ipilimumab in Men With Very High-risk Prostate Cancer acronym: NEPI overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-03 date: 2028-09 date: 2024-04-29 date: 2024-04-29 name: University Hospital, Essen class: OTHER name: Advanced Accelerator Applications name: Bristol-Myers Squibb briefSummary: A randomized, open-label Phase I/II study of neoadjuvant treatment with \[177Lu\]Lu-PSMA-617 radioligandtherapy (LuPSMA) with or without Ipilimumab in participants with very high-risk prostate cancer who are candidates for Radical Prostatectomy. conditions: Very High Risk Prostate Carcinoma studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The first patients are enrolled - without randomization - into the Safety Cohort to assess whether the treatment regime under investigation, i.e. Ipilimumab (3mg/kg) + \[177Lu\]Lu-PSMA-617 RLT (7,4 GBq), is appropriately tolerated as per dose escalation algorithm.
* Arm B: \[177Lu\]Lu-PSMA-617 RLT primaryPurpose: TREATMENT masking: NONE count: 58 type: ESTIMATED name: [177Lu]Lu-PSMA-617 name: Ipilimumab measure: Feasibility to perform prostatectomy on time measure: Clinical activity: Proportion of participants in the full analysis set who achieve a pCR measure: Safety Profile of neoadjuvant treatment before radical prostatectomy measure: Safety Profile of neoadjuvant treatment before radical prostatectomy sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Essen, Clinic of Urology city: Essen zip: 45147 country: Germany name: PD Dr. med. Ulrich Krafft role: CONTACT email: ulrich.krafft@uk-essen.de lat: 51.45657 lon: 7.01228 hasResults: False
nctId: NCT06388356 id: 042024 briefTitle: Patient's Informational Privacy in Prehospital Emergency Care - Educational Intervention Study for the Paramedics overallStatus: ENROLLING_BY_INVITATION date: 2024-03-25 date: 2024-05-19 date: 2024-06-16 date: 2024-04-29 date: 2024-04-29 name: Eini Koskimies class: OTHER briefSummary: The main goal of this educational intervention study about patient's informational privacy (IP) is to evaluate the effect of the educational intervention into the paramedics' knowledge and attitude regarding patient's IP. The study also investigates the usability and the feasibility of the educational intervention.
2. What is the usability and feasibility of the intervention being evaluated according to the respondents? conditions: Knowledge conditions: Attitude of Health Personnel studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two groups, intervention and control group. Only intervention group is receiveing the intervention. primaryPurpose: BASIC_SCIENCE masking: NONE count: 50 type: ESTIMATED name: Educational intervention - Yksityisyyttä ensihoitoon / Informational privacy for preospital emergency care measure: Paramedics' knowledge about patient's informational privacy measure: paramedics' attitude towards patient's informational privacy. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Turku city: Turku zip: 20520 country: Finland lat: 60.45148 lon: 22.26869 hasResults: False
nctId: NCT06388343 id: S68485 briefTitle: Causes of Listening Difficulties in Children acronym: CLINIC overallStatus: NOT_YET_RECRUITING date: 2025-01 date: 2027-12 date: 2027-12 date: 2024-04-29 date: 2024-04-29 name: Universitaire Ziekenhuizen KU Leuven class: OTHER name: Universitair Ziekenhuis Brussel briefSummary: Many children experience listening and processing difficulties (LiD), especially in background noise, despite normal hearing sensitivity. The prevalence of these problems is estimated at 0.5-1% in the general population. Listening difficulties are associated with developmental disorders (DD) such as specific language disorders, autism spectrum disorder (ASD), ADHD and learning disabilities. Many children with developmental problems are easily distracted by sounds, have difficulty concentrating for long periods, processing language, remembering and summarizing oral information, and can experience academic difficulties (reading, writing). Early identification, differential diagnosis and intervention are important to help children overcome these difficulties and reach their full potential. Some concerns about these listening and processing problems, such as the lack of a gold standard to diagnose LiD and age-appropriate reference data, led to the initiation of this study.
CLINIC aims to develop a new approach to diagnose the causes of listening difficulties in children. This is accomplished through (1) a validated parent questionnaire and (2) a multidisciplinary behavioral assessment tool. Data from these combined measures will lead to evidence-based profiles of children with LiD, which in turn will help streamline their referral pathways and care pathways. conditions: Listening Difficulties studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: SINGLE whoMasked: PARTICIPANT count: 280 type: ESTIMATED name: Evaluation of Children's Listening and Processing Skills name: Multidisciplinary behavioral assessment measure: ECLiPS questionnaire measure: Behavioral measures sex: ALL minimumAge: 6 Years maximumAge: 14 Years stdAges: CHILD hasResults: False
nctId: NCT06388330 id: s61692 briefTitle: The Effect of a Low FODMAP Diet in Functional Dyspepsia Patients With Meal Related Symptoms acronym: FFD overallStatus: COMPLETED date: 2019-04-26 date: 2022-03-08 date: 2022-03-08 date: 2024-04-29 date: 2024-04-29 name: Universitaire Ziekenhuizen KU Leuven class: OTHER briefSummary: In this study, the investigators will evaluate the FODMAP diet as an alternative treatment for functional dyspepsia and explore its effect on different aspects of the pathophysiology of FD. conditions: Functional Dyspepsia conditions: FODMAP Diet studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE maskingDescription: open label strict diet phase blinded participant during reintroduction count: 32 type: ACTUAL name: low FODMAP diet measure: Improvement on gastrointestinal symptoms measure: Reintroduction period measure: Evaluation of the low FODMAP diet on IBS related symptoms measure: Evaluation of the low FODMAP diet on symptom response and quality of life measure: Evaluation of the low FODMAP diet on depression, somatization measure: Evaluation of the low FODMAP diet on duodenal barrier function measure: Evaluation of the low FODMAP diet on gastric emptying measure: Evaluation of the low FODMAP diet on gastric accommodation sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: KU Leuven city: Leuven state: Vlaams-Brabant zip: 3000 country: Belgium lat: 50.87959 lon: 4.70093 hasResults: False
nctId: NCT06388317 id: 123632 briefTitle: Machine-based Algorithm for Increased Physical Activity and Sustained User Engagement overallStatus: ACTIVE_NOT_RECRUITING date: 2023-01-01 date: 2025-01-01 date: 2025-02-01 date: 2024-04-29 date: 2024-04-29 name: Western University, Canada class: OTHER briefSummary: This 12-week study compares the effectiveness of personalized daily step goals generated by a machine learning algorithm in the Sprout app versus fixed daily step goals of 10,000 steps among adults. Participants will be recruited through the Sprout app, and after a 1-week run-in period, they will be assigned to either the intervention or control group. The intervention group will receive adaptive goals based on their historical step data, while the control group will have a fixed goal. Both groups will receive financial incentives. This study aims to inform future interventions measuring changes in daily steps and app engagement levels (i.e., time spent on app, number of app opens) by studying how using financial incentives and an adaptive goal-setting design can improve physical activity levels of app users, informed by a machine learning algorithm. conditions: Health Behavior studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Retrospective, quasi-experimental study. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Participants are unaware of the other intervention arm (i.e., adaptive step goals versus static step goals). whoMasked: PARTICIPANT count: 500 type: ESTIMATED name: Adaptive Step Goal (Intervention) name: Static Step Goal (Control) measure: Step count measure: Number of app opens, total time spent on app, number of pages opened sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Western University city: London state: Ontario country: Canada lat: 42.98339 lon: -81.23304 hasResults: False
nctId: NCT06388304 id: 23-0556 briefTitle: THRIVE Study: Positive Affect Training for Endocrine Therapy Medication Adherence acronym: THRIVE overallStatus: RECRUITING date: 2024-03-12 date: 2024-10-12 date: 2024-12-12 date: 2024-04-29 date: 2024-04-29 name: Joanna Arch class: OTHER briefSummary: The purpose of this study is to pilot and refine an online behavioral intervention based on Positive Affect Training (PAT) that aims to increase positive emotional attitudes and decrease negative emotional attitudes toward endocrine therapy (ET, i.e., anti-hormonal medication) and to increase positive affect and decrease negative affect more generally, among post-treatment breast cancer survivors who are prescribed ET to prevent recurrence of breast cancer. conditions: Breast Cancer conditions: DCIS studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 40 type: ESTIMATED name: THRIVE Online PAT Program measure: Acceptability of THRIVE intervention (AIM) measure: Feasibility of THRIVE intervention measure: Client Satisfaction Survey sex: FEMALE minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Colorado Boulder status: RECRUITING city: Boulder state: Colorado zip: 80309 country: United States name: Sienna Russel role: CONTACT phone: 720-897-1850 email: archlab@colorado.edu name: Madeline Nealis, MPH role: CONTACT phone: 720-897-1850 email: archlab@colorado.edu name: Joanna Arch, PhD role: PRINCIPAL_INVESTIGATOR lat: 40.01499 lon: -105.27055 hasResults: False
nctId: NCT06388291 id: CTU/2018/321 briefTitle: Deep Brain Stimulation in Tourette Syndrome acronym: Op-TICS overallStatus: RECRUITING date: 2022-08-02 date: 2025-01 date: 2025-06-30 date: 2024-04-29 date: 2024-04-29 name: University College, London class: OTHER name: National Institute for Health Research, United Kingdom name: University College London Hospitals name: Northern Care Alliance NHS Foundation Trust name: St George's University Hospitals NHS Foundation Trust name: Royal Devon and Exeter NHS Foundation Trust name: University of Bristol name: University of Dundee name: London School of Hygiene and Tropical Medicine name: King's College London name: University Hospital, Rouen name: Imperial College London briefSummary: Op-TICS is a clinical investigation of the use of Deep Brain Stimulation (DBS), with a CE marked implantable device, to reduce severe motor and vocal tics in patients who suffer from Tourette Syndrome (TS).
The primary outcome measure is the tic severity score measured by the Yale Global Tic Severity Scale -Total Tic Score after two weeks OFF-stimulation versus two weeks ON-stimulation in the double-blind randomised crossover phase conditions: Tourette Syndrome conditions: Deep Brain Stimulation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: All participants will have electrodes implanted in the globus pallidus interna and connected to a subcutaneous pulse generator.
Following these 6 months, participants will be randomised into two groups by the order of treatment condition (ON/OFF-stimulation vs OFF/ON-stimulation): one group will be kept with the stimulation on ("ON-stimulation") and the other switched off ("OFF-stimulation") for up to two weeks. Tic severity will be assessed and all participants will enter a 2-day interval, in the ON state, before switching to the other treatment condition for another two weeks. primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: Double Blind whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: Deep Brain Stimulation measure: Tic severity score measured by the YGTSS-TTS (total tic) after two weeks OFF-stimulation versus two weeks ON-stimulation in the double-blind randomised crossover phase measure: MRVRS at the end of the OFF-stimulation state versus the end of the ON-stimulation state in the blinded, randomised crossover phase. measure: Change in the MRVRS between baseline 0 and the end of the open-phase (Baseline 1) measure: Change in the YGTSS (global) between baseline 0 and the end of the open-phase (Baseline 1) measure: Change in the GTS-QOL questionnaire measures at baseline 0 and the end of the open-phase (Baseline 1) measure: Change in the YBOCS between baseline 0 and the end of the open-phase (Baseline 1) measure: Change in the BDI scale between baseline 0 and the end of the open-phase (Baseline 1) measure: Change in the BAI scale between baseline 0 and the end of the open-phase (Baseline 1) measure: Change in the BAARS-IV between baseline 0 and the end of the open-phase (Baseline 1) measure: Safety of DBS as indicated by the number of participants with any adverse events and number with any serious adverse events measure: A mechanistic part of the study will look at possible explanations of differing responses in both the open and randomised phase. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Hospital of Neurology & Neurosurgery status: RECRUITING city: London country: United Kingdom name: Patricia Limousin role: CONTACT lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06388265 id: 18/2018, Acta 26-6-2018 briefTitle: Emotional and Oral Characteristics of Patients That Attend a Dental Consultation for the Extraction of Third Molars overallStatus: COMPLETED date: 2022-01-09 date: 2023-07-31 date: 2023-07-31 date: 2024-04-29 date: 2024-04-29 name: University of Barcelona class: OTHER briefSummary: Analyze the level of anxiety, hemodynamic parameters, oral status, and satisfaction among patients undergoing third molar extraction, we will assess those who attend the Master of Oral Medicine, Surgery, and Implantology program at the University of Barcelona. conditions: Anxiety and Fear studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 75 type: ACTUAL name: Trifold information measure: Changes in STAI-S measure: Changes in MDAS measure: Changes in blood pressure measure: Changes in Heart rate measure: Changes in Oxygen saturation measure: Patient Satisfaction of procedure sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Odontològic Universitat de Barcelona city: L'Hospitalet De Llobregat state: Barcelona zip: 08907 country: Spain lat: 41.35967 lon: 2.10028 hasResults: False