hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06371807 id: EU CTR n.º 2023-507008-30-00 briefTitle: Trial for Treatment of High Risk BC With Two Sequences of Neoadjuvant Chemotherapy With Pembrolizumab acronym: KEYPARTNER overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2025-07 date: 2026-12 date: 2024-04-17 date: 2024-04-17 name: Fundacao Champalimaud class: OTHER briefSummary: Phase II, randomized, Active-controlled open label trial for treatment of high risk, HR-/HER2- (triple negative) breast cancer, with two sequences of neoadjuvant chemotherapy on a background of pembrolizumab conditions: Early Breast Cancer conditions: Triple Negative Breast Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Pembrolizumab injection measure: Detect immunologic activation signal and the immunologically defined most suitable patient population for the synergistic interaction between pembrolizumab and chemotherapy backbone measure: Rate of pCR measure: Primary translational endpoint measure: Changes in the immunogenic phenotype measure: Incidence of treatment relatred Adverse events sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fundaçao Champalimaud, Avenida Brasilia, city: Lisbon zip: 1400-038 country: Portugal name: Ines Sousa, MSc role: CONTACT phone: +351 210480048 email: ines.sousa@fundacaochampalimaud.pt name: Fatima Cardoso, MD role: CONTACT phone: +351 210480048 email: fatimacardoso@fundacaochampalimaud.pt lat: 38.71667 lon: -9.13333 facility: Centro Hospitalar Universitário Lisboa Norte E.P.E city: Lisbon zip: 1649-028 country: Portugal lat: 38.71667 lon: -9.13333 facility: Instituto Português de Oncologia Francisco Gentil, E.P.E city: Oporto zip: 4200-072 country: Portugal name: Joana Maia role: CONTACT phone: 22 508 40 00 phoneExt: 2040 email: joana.h.maia@ipoporto.min-saude.pt name: Miguel Abreu, MD role: CONTACT phone: 22 508 40 00 phoneExt: 2040 email: antonio.m.abreu@ipoporto.min-saude.pt lat: 41.14961 lon: -8.61099 hasResults: False
nctId: NCT06371781 id: Cumhuriyetobgyn id: 1919B012108892 type: OTHER_GRANT domain: TUBITAK briefTitle: Examination of the Relationship Between Weight Gain During Pregnancy and Sfrp-5, Netrin-4 and Resistin Concentrations overallStatus: COMPLETED date: 2022-07-01 date: 2022-07-01 date: 2023-07-01 date: 2024-04-17 date: 2024-04-22 name: Cumhuriyet University class: OTHER name: Scientific and Technological Research Council of Turkey (TUBITAK) briefSummary: Researchers thought that the molecules Sfrp-5, Resistin and Netrin-4, which will be examine, they may have a significant effect on weight gain during pregnancy. Based on these foundations, researchers expect changes in the levels of these molecules in women who gain excessive weight during pregnancy. In this study, researchers aimed to examine the moderator relationship between the molecules will be examine and weight gain in women who gained weight above the normal limits determined during pregnancy. For this reason, 44 participant who gained excessive weight during pregnancy and 46 pregnant participant who gained normal weight were included in the study. The levels of Netrin-4, Sfrp-5 and Resistin molecules in the blood serum of the individuals in the study group were measured with a Commercial Elisa kit. conditions: Excessive Weight Gain During Pregnancy studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Pregnant women who were given birth at Cumhuriyet University Faculty of Medicine Hospital Gynecology and Obstetrics Clinic between July 1, 2021 and July 1, 2022 and whose pregnancy follow-ups were performed in our hospital will be included in our prospectively designed study. Researchers will divide the study into two main groups. The first group will consist of pregnant women with above-normal weight gain during pregnancy, and the other group will consist of pregnant women with normal weight gain during pregnancy. It is estimated that 46 control and 44 pregnant women with overweight will be reached during this period. In the study, first a form containing demographic data such as age, education, height and weight will be filled out. primaryPurpose: SCREENING masking: SINGLE whoMasked: PARTICIPANT count: 90 type: ACTUAL name: Serum Netrin-4, Resistin and Sfrp-5 level measurement measure: Obtaining blood serum for measurement of serum Sfrp-5, Netrin-4 and Resistin measure: Calculating BMI (kg/m^2) from height (m) and weight (kg) measurement values for diagnosis. sex: FEMALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Sivas Cumhuriyet University city: Sivas state: Centre zip: 58140 country: Turkey lat: 39.74833 lon: 37.01611 hasResults: False
nctId: NCT06371768 id: Pro00115400 briefTitle: Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors acronym: AYA STEPS overallStatus: NOT_YET_RECRUITING date: 2025-04-01 date: 2029-06-30 date: 2029-06-30 date: 2024-04-17 date: 2024-04-17 name: Duke University class: OTHER briefSummary: The purpose of this study is to determine the effectiveness of a digital health program called AYA STEPS, which is designed to help adolescent and young adult (AYA) cancer survivors manage symptoms and engage in recommended follow-up care. conditions: Cancer conditions: Breast Cancer conditions: Colorectal Cancer conditions: Sarcoma conditions: Lymphoma conditions: Testicular Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 260 type: ESTIMATED name: AYA Educational Information name: AYA STEPS measure: Pain severity and interference as measured by Brief Pain Inventory measure: Fatigue as measured by PROMIS Fatigue Scale measure: Emotional distress as measured by PROMIS Depression Short Form measure: Symptom interference as measured by MD Anderson Symptom Inventory (MDASI) Symptom Interference measure: Emotional distress as measured by PROMIS Anxiety Short Form measure: Health care engagement as measured by Patient Participation Questionnaire measure: Patient self-assessment of communication competency with health care providers as measured by Medical Communication Competence Scale (MCCS) patient subscale measure: Patient self-efficacy for chronic disease coping as measured by Self-Efficacy for Managing Chronic Illness Scale measure: Patient activation as measured by Patient Activation Measure (PAM) measure: Health care utilization: Chart Review measure: Area Deprivation Index (ADI) measure: Health-care utilization: Self-report measure: Health literacy as measured by Medical Term Recognition Test (METER) measure: Participant experiences of discrimination as measured by Everyday Discrimination Scale-Short Form measure: Participant evaluation of study mobile application as measured by User Version of the Mobile Application Rating Scale (uMARs) measure: Satisfaction with Treatment and Interventionist as measured by the Satisfaction with Therapy and Therapist Scale-Revised (STTS-R) measure: Web-based Portal Use as measured by total time using portal in minutes sex: ALL minimumAge: 18 Years maximumAge: 39 Years stdAges: ADULT hasResults: False
nctId: NCT06371755 id: ULTRADXA briefTitle: Bone Evaluation by Ultrasound Radiofrequency Echographic Multi Spectrometry (REMS) vs Dual X-ray Absorptiometry (DXA) overallStatus: RECRUITING date: 2019-11-19 date: 2024-12-31 date: 2024-12-31 date: 2024-04-17 date: 2024-04-17 name: Paola Pisani class: INDUSTRY name: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio briefSummary: Bone Density Evaluation by means of the Ultrasound Technology Named Radiofrequency Echographic Multi Spectrometry (REMS) in Comparison With DXA Technique.
Clinical Center involved in the study:IRCCS Orthopedic institute Galeazzi - Sant'Ambrogio The clinical study will evaluate the intra- and inter-operator repeatability of the REMS,(Radiofrequency Echographic Multi Spectrometry) ultrasound diagnostic technology implemented in the EchoStation device (Echolight Spa, Lecce) and the diagnostic accuracy in comparison with DXA (used as standard reference). conditions: Osteoporosis Diagnosis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 296 type: ESTIMATED name: Ultrasound examination with REMS technology measure: 1. REMS Technology intra - and inter-operator repeatability Evaluation. measure: 1. Evaluation of the accuracy of the REMS Technology in comparison with the conventional DXA technique. sex: FEMALE minimumAge: 30 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio status: RECRUITING city: Milano state: MI zip: 20157 country: Italy name: Carmelo Messina, Professor role: CONTACT phone: 0039 02 8350 1406 email: carmelomessina.md@gmail.com lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06371742 id: 539HydrationNutr briefTitle: Study of the Fluid Intake Effect During Labour overallStatus: COMPLETED date: 2017-02-01 date: 2017-07-14 date: 2017-09-14 date: 2024-04-17 date: 2024-04-17 name: Egas Moniz - Cooperativa de Ensino Superior, CRL class: OTHER briefSummary: Ingestion during labor is an issue that has attracted the attention of the scientific community in recent decades, with different practices occurring in different countries. However, the scientific evidence of the risk / benefit of fluid intake in labor is still not fully understood. The aim of this study was to contribute with data that allow the evaluation of an eventual relationship between the amount of fluid ingested during labor and the type of delivery, the duration of labor, the occurrence of nausea and vomiting and the value of the Index of Apgar at the 1st and 5th minutes of the newborn's life. An observational study, with a convenience sample of 144 parturient from two hospitals of Portugal were employed. The analysis was based on recording the before mentioned variables and potentially confounding variables. In order to control for potential sources of bias in the study and to guarantee the homogeneity of the sample in the specific statistical treatment of each dependent variable, an observation grid was drawn up for all the participants in the study. Twenty eight of the parturient, the parturient's ambulation, labour analgesia, food intake during labour, the use of oxytocin during labour, the occurrence of postpartum complications, the birth weight of the newborn and the occurrence of birth complications. conditions: Labor Complication studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 144 type: ACTUAL name: Liquid ingestion during labour measure: Type of labour measure: Duration of labour measure: Occurrence of nausea and vomiting measure: Apgar index of the newborn (From 0 to 10) sex: FEMALE minimumAge: 18 Years maximumAge: 39 Years stdAges: ADULT facility: Egas Moniz School of Health and Science city: Almada state: Monte De Caparica zip: 2829-699 country: Portugal lat: 38.67902 lon: -9.1569 hasResults: False
nctId: NCT06371729 id: DEEP-VT briefTitle: Substrate-based DEEP Mapping Versus Activation Mapping. A Prospective Randomized Multicenter Study. overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2027-07 date: 2027-07 date: 2024-04-17 date: 2024-04-18 name: IRCCS Ospedale San Raffaele class: OTHER briefSummary: Substrate-based DEEP mapping and activation mapping are the two main techniques used for ventricular tachycardia (VT) ablation. There is no sufficiently reliable data in the medical scientific literature comparing the extent of applicability, the results of the procedure strategy, and the long-term outcomes between the two mapping strategies. This randomized clinical trial aims to test whether activation mapping is superior to DEEP mapping to reduce ventricular tachycardia recurrence.
The primary outcome of the study is to compare the efficacy as a recurrence-free survival rate of ventricular tachycardia, at 6 and 12 months, of substrate-based DEEP mapping versus activation mapping in guiding catheter ablation to prevent VT recurrence. conditions: Ventricular Tachycardia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 222 type: ESTIMATED name: DEEP mapping name: Activation Mapping measure: Compare the efficacy of substrate-based DEEP mapping versus Activation mapping in guiding catheter ablation to prevent VT recurrences sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06371716 id: EUS-RFA ex-vivo 2016 briefTitle: Ex-vivo Ultrasound Guided Radiofrequency Ablation on Pancreatic Solid Lesions overallStatus: TERMINATED date: 2019-09-12 date: 2020-06-12 date: 2020-06-12 date: 2024-04-17 date: 2024-04-17 name: IRCCS San Raffaele class: OTHER briefSummary: The study investigates the feasibility and the efficacy to treat pancreatic solid lesions as pancreatic adenocarcinomas (PDAC) and neuroendocrine tumors (NET) with ex-vivo radiofrequency ablation (RFA) under ultrasound (US) control.
The study intent is to define the optimal radiofrequency ablation POWER of the system in terms of maximum sizes (diameters) of histological coagulative necrosis obtained at pathological samples. Results will be useful to define the optimal settings to ablate pancreatic solid lesions (PDAC and neuroendocrine tumours). conditions: Pancreatic Cancer conditions: Endoscopic Ultrasound conditions: Radiofrequency Ablation studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 15 resected PDAC without neoadjuvant treatment 15 resected PDAC with neoadjuvant treatment 15 resected neuroendocrine tumors
Each group (15 patients each) Subgroup A: 10 W (5 patients) Subgroup B: 30 W (5 patients) Subgroup C: 50 W (5 patients) primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: pathologists (two different pathologist blinded about the power of RFA applied and respect to the other pathologist) will evaluate the effect of ablation (coagulative necrosis at microscopic evaluation) whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 45 type: ACTUAL name: ex-vivo RFA under US control at 10 Watts (W) of power in 3 differents arms of lesions name: ex-vivo RFA under US control at 30 Watts (W) of power in 3 differents arms of lesions name: ex-vivo RFA under US control at 50 Watts (W) of power in 3 differents arms of lesions measure: diameter (millimeters) of coagulative necrosis obtained by RadioFrequency Ablation sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS San Raffaele Hospital city: Milan country: Italy lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06371703 id: PETCT_INTEGO briefTitle: Enhancing Radiation Safety for Nuclear Medicine Radiographers: the Impact of Introducing the Automat-ed Radiopharmaceutical Preparation and Administration System overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2024-10 date: 2024-10 date: 2024-04-17 date: 2024-04-19 name: IRCCS San Raffaele class: OTHER briefSummary: This project aims to evaluate the impact of the introduction of an automated system for radiopharmaceutical preparation and administration on the radiation safety of the radiographers working in nuclear medicine. This study will help to fill the existing gap in the scientific literature and provide useful guidance for the selection of the safest and most effective automated infusion system. conditions: Radiation Exposure studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 100 type: ESTIMATED name: automated system in reducing radiation exposure measure: Change in absorbed dose by radiographers during PET/CT procedures, measured in millisieverts (mSv). sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Irccs San Raffaele city: Milano country: Italy lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06371690 id: 17-11/37 briefTitle: The Effects of Using the Web-Based Double Eye Control Program on Medication Error overallStatus: COMPLETED date: 2017-11-01 date: 2018-06-30 date: 2018-09-30 date: 2024-04-17 date: 2024-04-17 name: Izmir Katip Celebi University class: OTHER name: Ege University briefSummary: Methods: The study was carried out as a quasi-experimental study in the Pediatric Surgery Clinics of a university hospital using the "Pre-Test-Post-Test Model in a Single Group". The sample of the study consisted of all high-risk drugs administered by 24 nurses working in these clinics, taking part in medication and agreeing to take part in the study. Data were collected by the researcher using the Medication Observation Form. The Form was created based on the literature, and by making use of the "10 Correct Rules in Medication" and the Medication Skills Steps in the Double Eye Control Program. In the first step, medication error rates were determined through observation method. In the second step; the Web-Based Double-Eye Control Program, which is a standard drug dose calculation and medication program created by the researchers, was started to be implemented. Medication error rates were determined again through post-intervention observation method. Informed voluntary consent, ethics committee and hospital permissions were obtained for the implementation of the study. conditions: Main Heading (Descriptor) Terms studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 1070 type: ACTUAL name: Web-Based Double-Eye Control Program measure: Error rates sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Izmir Katip Celebi University city: İzmir state: Çi̇ğli̇ zip: 35620 country: Turkey lat: 38.41273 lon: 27.13838 hasResults: False
nctId: NCT06371677 id: KB/2024 briefTitle: Polish Nationwide Register of Hospitalized Patients in Cardiac Intensive Care Units acronym: POL-CICU overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2024-12-31 date: 2025-03-31 date: 2024-04-17 date: 2024-04-17 name: Medical University of Warsaw class: OTHER briefSummary: Cardiac Intensive Care Units (CICUs) provide care for a diverse patient population. Understanding the clinical characteristics, analysis of treatment modalities, and prognosis of patients hospitalized in the CICU are important to improve cardiovascular care. The purpose of this registry is to determine the demographics, clinical, treatment, and prognosis of patients hospitalized in the Polish CICUs. Data from this multicenter, prospective observational study will provide more robust data to facilitate quantitative characterization of cardiac care in contemporary Polish CICUs and enable the development of infrastructure for clinical trials in CICUs. conditions: Shock conditions: Death conditions: Cardiac Intensive Care Unit conditions: Treatment Complication conditions: Stroke conditions: Multiple Organ Failure conditions: Infections studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2000 type: ESTIMATED measure: All-cause death measure: Shock (cardiogenic/hypovolemic/anaphylactic/septic/neurogenic/obstructive) measure: Treatment-related complications (tamponade, dissection, stroke, embolism, etc.) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06371664 id: 2023/02 briefTitle: Gingival Irritation Due to Bleaching Tray Design in an At-home Bleaching Treatment overallStatus: COMPLETED date: 2023-03-01 date: 2023-04-05 date: 2023-04-05 date: 2024-04-17 date: 2024-04-17 name: University of Santiago de Compostela class: OTHER briefSummary: The primary aim of this study is to assess whether the design of the bleaching tray used in at-home bleaching treatment is directly correlated with the risk of gingival irritation. Additionally, it aims to investigate whether the design influences the likelihood of dental sensitivity and its impact on the degree of tooth whitening. conditions: Gingival Inflammation studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized, triple-blind clinical trial primaryPurpose: PREVENTION masking: TRIPLE whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 72 type: ACTUAL name: Conventional Tray (1 mm) name: Extended Tray (3 mm) measure: Subjective questionnaire of gingival irritation measure: Objective clinical examination of gingival irritation measure: Questionnaire of dental sensitivity measure: Shade evaluation with a dental spectrophotometer sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: School of Medicine and Dentistry city: Santiago De Compostela state: A Coruña zip: 15705 country: Spain lat: 42.88052 lon: -8.54569 hasResults: False
nctId: NCT06371651 id: 23-1462-3 briefTitle: Creatine and GAA for Brain Oxygenation acronym: CREGAA-OXY overallStatus: COMPLETED date: 2024-03-01 date: 2024-04-10 date: 2024-04-12 date: 2024-04-17 date: 2024-04-17 name: University of Novi Sad, Faculty of Sport and Physical Education class: OTHER briefSummary: The main aim of this randomized controlled trial is to evaluate cerebral blood oxygenation after 7-day administration of a creatine-guanidinoacetic acid (GAA) mixture in healthy adults before, during, and after a series of cognitive tests. conditions: Oxygen Deficiency studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 19 type: ACTUAL name: Supplement name: Placebo measure: Brain oxygen saturation measure: Hemoglobin index sex: ALL minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Applied Bioenergetics Lab at Faculty of Sport and PE city: Novi Sad state: Vojvodina zip: 21000 country: Serbia lat: 45.25167 lon: 19.83694 hasResults: False
nctId: NCT06371638 id: 2024-01 briefTitle: Dexmedetomidine and Postoperative Cognitive Dysfunction (POCD) acronym: CODE-POCD overallStatus: COMPLETED date: 2024-01-07 date: 2024-03-01 date: 2024-03-07 date: 2024-04-17 date: 2024-04-19 name: Udayana University class: OTHER briefSummary: Postoperative cognitive dysfunction (POCD) affects all age groups and can lead to increased morbidity and more extended hospital stays. Dexmedetomidine reduces POCD by inhibiting the increase in proinflammatory cytokines IL-6 and TNF-α, and its anti-inflammatory activity contributes to its protective effect. Previous studies found that dexmedetomidine reduced POCD incidence in non-cardiac and cardiac surgery. Therefore, the goal of this study was to specifically investigate if using TCI dexmedetomidine to maintain anaesthesia in laparotomy surgeries reduces the incidence of POCD compared to inhalation anaesthesia by sevoflurane. conditions: Postoperative Cognitive Dysfunction conditions: Postoperative Pain studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE whoMasked: PARTICIPANT count: 112 type: ACTUAL name: Dexmedetomidine name: Sevoflurane measure: Postoperative cognitive dysfunction (POCD) measure: Postoperative cognitive dysfunction (POCD) measure: Intraoperative hemodynamics: mean arterial pressure (MAP) measure: Intraoperative hemodynamics: heart rate (HR) measure: Postoperative pain measure: Postoperative pain measure: Postoperative pain sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Prof. Ngoerah General Hospital city: Denpasar state: Bali zip: 80114 country: Indonesia lat: -8.65 lon: 115.21667 hasResults: False