nctId: NCT06283966 id: D5989C00001 briefTitle: A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease acronym: THARROS overallStatus: RECRUITING date: 2024-02-21 date: 2028-03-06 date: 2028-03-06 date: 2024-02-28 date: 2024-03-12 name: AstraZeneca class: INDUSTRY briefSummary: This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated cardiopulmonary risk. conditions: COPD (Chronic Obstructive Pulmonary Disease) studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a Phase III randomized, double-blind, parallel group, multi-center event-driven study comparing BGF MDI 320/14.4/9.6 μg BID with GFF MDI 14.4/9.6 μg BID in participants with COPD who are at risk of a cardiopulmonary event. primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 5000 type: ESTIMATED name: BGF MDI 320/14.4/9.6 μg name: GFF MDI 14.4/9.6 μg measure: Time to first severe cardiac or COPD event measure: Time to first severe COPD exacerbation event measure: Time to first severe cardiac event measure: Time to cardiopulmonary death measure: Moderate/severe COPD exacerbation rate measure: Time to Myocardial Infarction (MI) hospitalization or cardiac death measure: Time to Heart Failure (HF) acute healthcare visit/hospitalization or cardiac death measure: Serious Adverse Events (SAEs) and Adverse Events leading to discontinuation (DAEs), Adverse Events of Special Interest (AESIs) of pneumonia leading to hospitalization or death sex: ALL minimumAge: 40 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Research Site status: NOT_YET_RECRUITING city: Athens state: Alabama zip: 35611 country: United States lat: 34.80243 lon: -86.97219 facility: Research Site status: NOT_YET_RECRUITING city: Cullman state: Alabama zip: 35058 country: United States lat: 34.17482 lon: -86.84361 facility: Research Site status: RECRUITING city: Fairhope state: Alabama zip: 36532 country: United States lat: 30.52297 lon: -87.90333 facility: Research Site status: NOT_YET_RECRUITING city: Huntsville state: Alabama zip: 35801 country: United States lat: 34.7304 lon: -86.58594 facility: Research Site status: NOT_YET_RECRUITING city: Mobile state: Alabama zip: 36608 country: United States lat: 30.69436 lon: -88.04305 facility: Research Site status: NOT_YET_RECRUITING city: Sheffield state: Alabama zip: 35660 country: United States lat: 34.76509 lon: -87.69864 facility: Research Site status: NOT_YET_RECRUITING city: Gilbert state: Arizona zip: 85296 country: United States lat: 33.35283 lon: -111.78903 facility: Research Site status: NOT_YET_RECRUITING city: Glendale state: Arizona zip: 85308 country: United States lat: 33.53865 lon: -112.18599 facility: Research Site status: RECRUITING city: Mesa state: Arizona zip: 85206 country: United States lat: 33.42227 lon: -111.82264 facility: Research Site status: NOT_YET_RECRUITING city: Mesa state: Arizona zip: 85213 country: United States lat: 33.42227 lon: -111.82264 facility: Research Site status: NOT_YET_RECRUITING city: Phoenix state: Arizona zip: 85006 country: United States lat: 33.44838 lon: -112.07404 facility: Research Site status: NOT_YET_RECRUITING city: Tempe state: Arizona zip: 85281 country: United States lat: 33.41477 lon: -111.90931 facility: Research Site status: NOT_YET_RECRUITING city: Tempe state: Arizona zip: 85283 country: United States lat: 33.41477 lon: -111.90931 facility: Research Site status: NOT_YET_RECRUITING city: Tucson state: Arizona zip: 85710 country: United States lat: 32.22174 lon: -110.92648 facility: Research Site status: NOT_YET_RECRUITING city: Apple Valley state: California zip: 92307 country: United States lat: 34.50083 lon: -117.18588 facility: Research Site status: NOT_YET_RECRUITING city: Banning state: California zip: 92220 country: United States lat: 33.92557 lon: -116.87641 facility: Research Site status: NOT_YET_RECRUITING city: Canoga Park state: California zip: 91303 country: United States lat: 34.20112 lon: -118.59814 facility: Research Site status: NOT_YET_RECRUITING city: Garden Grove state: California zip: 92844 country: United States lat: 33.77391 lon: -117.94145 facility: Research Site status: NOT_YET_RECRUITING city: Gardena state: California zip: 90247 country: United States lat: 33.88835 lon: -118.30896 facility: Research Site status: NOT_YET_RECRUITING city: Inglewood state: California zip: 90301 country: United States lat: 33.96168 lon: -118.35313 facility: Research Site status: NOT_YET_RECRUITING city: La Mesa state: California zip: 91942 country: United States lat: 32.76783 lon: -117.02308 facility: Research Site status: NOT_YET_RECRUITING city: La Palma state: California zip: 90623 country: United States lat: 33.8464 lon: -118.04673 facility: Research Site status: NOT_YET_RECRUITING city: Lomita state: California zip: 90717 country: United States lat: 33.79224 lon: -118.31507 facility: Research Site status: NOT_YET_RECRUITING city: Los Alamitos state: California zip: 90720 country: United States lat: 33.80307 lon: -118.07256 facility: Research Site status: NOT_YET_RECRUITING city: Newport Beach state: California zip: 92660 country: United States lat: 33.61891 lon: -117.92895 facility: Research Site status: RECRUITING city: Newport Beach state: California zip: 92663 country: United States lat: 33.61891 lon: -117.92895 facility: Research Site status: NOT_YET_RECRUITING city: North Hollywood state: California zip: 91602 country: United States lat: 34.17223 lon: -118.37897 facility: Research Site status: NOT_YET_RECRUITING city: Panorama City state: California zip: 91402 country: United States lat: 34.22473 lon: -118.44981 facility: Research Site status: NOT_YET_RECRUITING city: Pomona state: California zip: 91768 country: United States lat: 34.05529 lon: -117.75228 facility: Research Site status: NOT_YET_RECRUITING city: Sacramento state: California zip: 95823 country: United States lat: 38.58157 lon: -121.4944 facility: Research Site status: NOT_YET_RECRUITING city: Sacramento state: California zip: 95831 country: United States lat: 38.58157 lon: -121.4944 facility: Research Site status: NOT_YET_RECRUITING city: Salinas state: California zip: 93901 country: United States lat: 36.67774 lon: -121.6555 facility: Research Site status: NOT_YET_RECRUITING city: San Diego state: California zip: 92111 country: United States lat: 32.71533 lon: -117.15726 facility: Research Site status: NOT_YET_RECRUITING city: San Dimas state: California zip: 91773 country: United States lat: 34.10668 lon: -117.80673 facility: Research Site status: NOT_YET_RECRUITING city: Santa Ana state: California zip: 92704 country: United States lat: 33.74557 lon: -117.86783 facility: Research Site status: NOT_YET_RECRUITING city: Tarzana state: California zip: 91356 country: United States lat: 34.17334 lon: -118.55397 facility: Research Site status: NOT_YET_RECRUITING city: Thousand Oaks state: California zip: 91360 country: United States lat: 34.17056 lon: -118.83759 facility: Research Site status: NOT_YET_RECRUITING city: Vista state: California zip: 92081 country: United States lat: 33.20004 lon: -117.24254 facility: Research Site status: NOT_YET_RECRUITING city: Westminster state: California zip: 92683 country: United States lat: 33.75918 lon: -118.00673 facility: Research Site status: NOT_YET_RECRUITING city: Aurora state: Colorado zip: 80012 country: United States lat: 39.72943 lon: -104.83192 facility: Research Site status: NOT_YET_RECRUITING city: Denver state: Colorado zip: 80224 country: United States lat: 39.73915 lon: -104.9847 facility: Research Site status: NOT_YET_RECRUITING city: Denver state: Colorado zip: 80228 country: United States lat: 39.73915 lon: -104.9847 facility: Research Site status: NOT_YET_RECRUITING city: Washington state: District of Columbia zip: 20016 country: United States lat: 38.89511 lon: -77.03637 facility: Research Site status: NOT_YET_RECRUITING city: Boynton Beach state: Florida zip: 33435 country: United States lat: 26.52535 lon: -80.06643 facility: Research Site status: NOT_YET_RECRUITING city: Bradenton state: Florida zip: 34208 country: United States lat: 27.49893 lon: -82.57482 facility: Research Site status: NOT_YET_RECRUITING city: Cape Coral state: Florida zip: 33990 country: United States lat: 26.56285 lon: -81.94953 facility: Research Site status: NOT_YET_RECRUITING city: Clearwater state: Florida zip: 33756 country: United States lat: 27.96585 lon: -82.8001 facility: Research Site status: NOT_YET_RECRUITING city: Clearwater state: Florida zip: 33765 country: United States lat: 27.96585 lon: -82.8001 facility: Research Site status: NOT_YET_RECRUITING city: Crystal River state: Florida zip: 34429 country: United States lat: 28.90248 lon: -82.5926 facility: Research Site status: NOT_YET_RECRUITING city: Cutler Bay state: Florida zip: 33189 country: United States lat: 25.5783 lon: -80.3377 facility: Research Site status: NOT_YET_RECRUITING city: Edgewater state: Florida zip: 32132 country: United States lat: 28.98888 lon: -80.90228 facility: Research Site status: NOT_YET_RECRUITING city: Fort Lauderdale state: Florida zip: 33308 country: United States lat: 26.12231 lon: -80.14338 facility: Research Site status: NOT_YET_RECRUITING city: Fort Myers state: Florida zip: 33912 country: United States lat: 26.62168 lon: -81.84059 facility: Research Site status: NOT_YET_RECRUITING city: Hialeah state: Florida zip: 33013 country: United States lat: 25.8576 lon: -80.27811 facility: Research Site status: NOT_YET_RECRUITING city: Hollywood state: Florida zip: 33024 country: United States lat: 26.0112 lon: -80.14949 facility: Research Site status: NOT_YET_RECRUITING city: Kissimmee state: Florida zip: 34741 country: United States lat: 28.30468 lon: -81.41667 facility: Research Site status: NOT_YET_RECRUITING city: Kissimmee state: Florida zip: 34746 country: United States lat: 28.30468 lon: -81.41667 facility: Research Site status: NOT_YET_RECRUITING city: Lake City state: Florida zip: 32055 country: United States lat: 30.18968 lon: -82.63929 facility: Research Site status: NOT_YET_RECRUITING city: Lake Worth state: Florida zip: 33467 country: United States lat: 26.61708 lon: -80.07231 facility: Research Site status: NOT_YET_RECRUITING city: Lakeland state: Florida zip: 33813 country: United States lat: 28.03947 lon: -81.9498 facility: Research Site status: NOT_YET_RECRUITING city: Loxahatchee Groves state: Florida zip: 33470 country: United States lat: 26.68368 lon: -80.27977 facility: Research Site status: NOT_YET_RECRUITING city: Miami Lakes state: Florida zip: 33014 country: United States lat: 25.90871 lon: -80.30866 facility: Research Site status: NOT_YET_RECRUITING city: Miami state: Florida zip: 33155 country: United States lat: 25.77427 lon: -80.19366 facility: Research Site status: RECRUITING city: Miami state: Florida zip: 33175 country: United States lat: 25.77427 lon: -80.19366 facility: Research Site status: NOT_YET_RECRUITING city: Miami state: Florida zip: 33256 country: United States lat: 25.77427 lon: -80.19366 facility: Research Site status: NOT_YET_RECRUITING city: Naples state: Florida zip: 34102 country: United States lat: 26.14234 lon: -81.79596 facility: Research Site status: NOT_YET_RECRUITING city: Ocala state: Florida zip: 34470 country: United States lat: 29.1872 lon: -82.14009 facility: Research Site status: NOT_YET_RECRUITING city: Orlando state: Florida zip: 32807 country: United States lat: 28.53834 lon: -81.37924 facility: Research Site status: NOT_YET_RECRUITING city: Orlando state: Florida zip: 32819 country: United States lat: 28.53834 lon: -81.37924 facility: Research Site status: NOT_YET_RECRUITING city: Orlando state: Florida zip: 32825 country: United States lat: 28.53834 lon: -81.37924 facility: Research Site status: NOT_YET_RECRUITING city: Ormond Beach state: Florida zip: 32174 country: United States lat: 29.28581 lon: -81.05589 facility: Research Site status: NOT_YET_RECRUITING city: Pembroke Pines state: Florida zip: 33024 country: United States lat: 26.00315 lon: -80.22394 facility: Research Site status: NOT_YET_RECRUITING city: Plantation state: Florida zip: 33324 country: United States lat: 26.13421 lon: -80.23184 facility: Research Site status: NOT_YET_RECRUITING city: Saint Petersburg state: Florida zip: 33713 country: United States lat: 27.77086 lon: -82.67927 facility: Research Site status: NOT_YET_RECRUITING city: Sun City Center state: Florida zip: 33573 country: United States lat: 27.71809 lon: -82.35176 facility: Research Site status: NOT_YET_RECRUITING city: Tamarac state: Florida zip: 33321 country: United States lat: 26.21286 lon: -80.24977 facility: Research Site status: NOT_YET_RECRUITING city: Tampa state: Florida zip: 33606 country: United States lat: 27.94752 lon: -82.45843 facility: Research Site status: NOT_YET_RECRUITING city: Tampa state: Florida zip: 33607 country: United States lat: 27.94752 lon: -82.45843 facility: Research Site status: NOT_YET_RECRUITING city: Tampa state: Florida zip: 33625 country: United States lat: 27.94752 lon: -82.45843 facility: Research Site status: NOT_YET_RECRUITING city: Atlanta state: Georgia zip: 30349 country: United States lat: 33.749 lon: -84.38798 facility: Research Site status: NOT_YET_RECRUITING city: Buford state: Georgia zip: 30519 country: United States lat: 34.12066 lon: -84.00435 facility: Research Site status: NOT_YET_RECRUITING city: Peachtree Corners state: Georgia zip: 30092 country: United States lat: 33.9701 lon: -84.22159 facility: Research Site status: NOT_YET_RECRUITING city: Savannah state: Georgia zip: 31406 country: United States lat: 32.08354 lon: -81.09983 facility: Research Site status: NOT_YET_RECRUITING city: Boise state: Idaho zip: 83706 country: United States lat: 43.6135 lon: -116.20345 facility: Research Site status: NOT_YET_RECRUITING city: Chicago state: Illinois zip: 60607 country: United States lat: 41.85003 lon: -87.65005 facility: Research Site status: NOT_YET_RECRUITING city: Winfield state: Illinois zip: 60190 country: United States lat: 41.8617 lon: -88.1609 facility: Research Site status: NOT_YET_RECRUITING city: Valparaiso state: Indiana zip: 46383 country: United States lat: 41.47309 lon: -87.06114 facility: Research Site status: NOT_YET_RECRUITING city: Newton state: Kansas zip: 67114 country: United States lat: 38.04668 lon: -97.34504 facility: Research Site status: NOT_YET_RECRUITING city: Wichita state: Kansas zip: 67218 country: United States lat: 37.69224 lon: -97.33754 facility: Research Site status: NOT_YET_RECRUITING city: Lexington state: Kentucky zip: 40503 country: United States lat: 37.98869 lon: -84.47772 facility: Research Site status: NOT_YET_RECRUITING city: Paducah state: Kentucky zip: 42001 country: United States lat: 37.08339 lon: -88.60005 facility: Research Site status: NOT_YET_RECRUITING city: Lafayette state: Louisiana zip: 70508 country: United States lat: 30.22409 lon: -92.01984 facility: Research Site status: NOT_YET_RECRUITING city: Monroe state: Louisiana zip: 71201 country: United States lat: 32.50931 lon: -92.1193 facility: Research Site status: RECRUITING city: Shreveport state: Louisiana zip: 71105 country: United States lat: 32.52515 lon: -93.75018 facility: Research Site status: NOT_YET_RECRUITING city: Zachary state: Louisiana zip: 70791 country: United States lat: 30.64852 lon: -91.1565 facility: Research Site status: NOT_YET_RECRUITING city: Oxon Hill state: Maryland zip: 20745 country: United States lat: 38.80345 lon: -76.9897 facility: Research Site status: NOT_YET_RECRUITING city: Potomac state: Maryland zip: 20854 country: United States lat: 39.01817 lon: -77.20859 facility: Research Site status: NOT_YET_RECRUITING city: Boston state: Massachusetts zip: 02115 country: United States lat: 42.35843 lon: -71.05977 facility: Research Site status: NOT_YET_RECRUITING city: Flint state: Michigan zip: 48504 country: United States lat: 43.01253 lon: -83.68746 facility: Research Site status: NOT_YET_RECRUITING city: Lathrup Village state: Michigan zip: 48076 country: United States lat: 42.49642 lon: -83.22271 facility: Research Site status: NOT_YET_RECRUITING city: Southfield state: Michigan zip: 48034 country: United States lat: 42.47337 lon: -83.22187 facility: Research Site status: RECRUITING city: Gulfport state: Mississippi zip: 39503 country: United States lat: 30.36742 lon: -89.09282 facility: Research Site status: NOT_YET_RECRUITING city: Olive Branch state: Mississippi zip: 38654 country: United States lat: 34.96176 lon: -89.82953 facility: Research Site status: NOT_YET_RECRUITING city: Kansas City state: Missouri zip: 64116 country: United States lat: 39.09973 lon: -94.57857 facility: Research Site status: NOT_YET_RECRUITING city: Liberty state: Missouri zip: 64068 country: United States lat: 39.24611 lon: -94.41912 facility: Research Site status: NOT_YET_RECRUITING city: Saint Louis state: Missouri zip: 63136 country: United States lat: 38.62727 lon: -90.19789 facility: Research Site status: RECRUITING city: Missoula state: Montana zip: 59808 country: United States lat: 46.87215 lon: -113.994 facility: Research Site status: NOT_YET_RECRUITING city: Fremont state: Nebraska zip: 68025 country: United States lat: 41.43333 lon: -96.49808 facility: Research Site status: NOT_YET_RECRUITING city: Grand Island state: Nebraska zip: 68803 country: United States lat: 40.92501 lon: -98.34201 facility: Research Site status: NOT_YET_RECRUITING city: Omaha state: Nebraska zip: 68134 country: United States lat: 41.25626 lon: -95.94043 facility: Research Site status: NOT_YET_RECRUITING city: Las Vegas state: Nevada zip: 89101 country: United States lat: 36.17497 lon: -115.13722 facility: Research Site status: NOT_YET_RECRUITING city: Las Vegas state: Nevada zip: 89102 country: United States lat: 36.17497 lon: -115.13722 facility: Research Site status: NOT_YET_RECRUITING city: Las Vegas state: Nevada zip: 89119 country: United States lat: 36.17497 lon: -115.13722 facility: Research Site status: NOT_YET_RECRUITING city: Lawrence Township state: New Jersey zip: 08648 country: United States lat: 40.29588 lon: -74.72009 facility: Research Site status: NOT_YET_RECRUITING city: Mullica Hill state: New Jersey zip: 08062 country: United States lat: 39.73928 lon: -75.22407 facility: Research Site status: NOT_YET_RECRUITING city: Toms River state: New Jersey zip: 08755 country: United States lat: 39.95373 lon: -74.19792 facility: Research Site status: WITHDRAWN city: Union City state: New Jersey zip: 07087 country: United States lat: 40.77955 lon: -74.02375 facility: Research Site status: WITHDRAWN city: Albuquerque state: New Mexico zip: 87109 country: United States lat: 35.08449 lon: -106.65114 facility: Research Site status: NOT_YET_RECRUITING city: Albany state: New York zip: 12205 country: United States lat: 42.65258 lon: -73.75623 facility: Research Site status: NOT_YET_RECRUITING city: Bronxville state: New York zip: 10708 country: United States lat: 40.93815 lon: -73.83208 facility: Research Site status: RECRUITING city: Bronx state: New York zip: 10455 country: United States lat: 40.84985 lon: -73.86641 facility: Research Site status: NOT_YET_RECRUITING city: Massapequa state: New York zip: 11758 country: United States lat: 40.68066 lon: -73.47429 facility: Research Site status: NOT_YET_RECRUITING city: New Windsor state: New York zip: 12553 country: United States lat: 41.47676 lon: -74.02375 facility: Research Site status: NOT_YET_RECRUITING city: New York state: New York zip: 10036 country: United States lat: 40.71427 lon: -74.00597 facility: Research Site status: NOT_YET_RECRUITING city: Vestal state: New York zip: 13850 country: United States lat: 42.08507 lon: -76.05381 facility: Research Site status: NOT_YET_RECRUITING city: Fayetteville state: North Carolina zip: 28303 country: United States lat: 35.05266 lon: -78.87836 facility: Research Site status: NOT_YET_RECRUITING city: Greensboro state: North Carolina zip: 27405 country: United States lat: 36.07264 lon: -79.79198 facility: Research Site status: NOT_YET_RECRUITING city: Greenville state: North Carolina zip: 27834 country: United States lat: 35.61266 lon: -77.36635 facility: Research Site status: NOT_YET_RECRUITING city: Huntersville state: North Carolina zip: 28078 country: United States lat: 35.41069 lon: -80.84285 facility: Research Site status: NOT_YET_RECRUITING city: Morehead City state: North Carolina zip: 28557 country: United States lat: 34.72294 lon: -76.72604 facility: Research Site status: NOT_YET_RECRUITING city: Raleigh state: North Carolina zip: 27612 country: United States lat: 35.7721 lon: -78.63861 facility: Research Site status: NOT_YET_RECRUITING city: Salisbury state: North Carolina zip: 28144 country: United States lat: 35.67097 lon: -80.47423 facility: Research Site status: NOT_YET_RECRUITING city: Statesville state: North Carolina zip: 28625 country: United States lat: 35.78264 lon: -80.8873 facility: Research Site status: NOT_YET_RECRUITING city: Statesville state: North Carolina zip: 28677 country: United States lat: 35.78264 lon: -80.8873 facility: Research Site status: NOT_YET_RECRUITING city: Wilmington state: North Carolina zip: 28401 country: United States lat: 34.22573 lon: -77.94471 facility: Research Site status: NOT_YET_RECRUITING city: Beavercreek state: Ohio zip: 45431 country: United States lat: 39.70923 lon: -84.06327 facility: Research Site status: NOT_YET_RECRUITING city: Blue Ash state: Ohio zip: 45242 country: United States lat: 39.232 lon: -84.37827 facility: Research Site status: NOT_YET_RECRUITING city: Cleveland state: Ohio zip: 44130 country: United States lat: 41.4995 lon: -81.69541 facility: Research Site status: RECRUITING city: Columbus state: Ohio zip: 43215 country: United States lat: 39.96118 lon: -82.99879 facility: Research Site status: NOT_YET_RECRUITING city: Columbus state: Ohio zip: 43235 country: United States lat: 39.96118 lon: -82.99879 facility: Research Site status: NOT_YET_RECRUITING city: Marion state: Ohio zip: 43302 country: United States lat: 40.58867 lon: -83.12852 facility: Research Site status: NOT_YET_RECRUITING city: Toledo state: Ohio zip: 43617 country: United States lat: 41.66394 lon: -83.55521 facility: Research Site status: NOT_YET_RECRUITING city: Norman state: Oklahoma zip: 73071 country: United States lat: 35.22257 lon: -97.43948 facility: Research Site status: NOT_YET_RECRUITING city: Oklahoma City state: Oklahoma zip: 73134 country: United States lat: 35.46756 lon: -97.51643 facility: Research Site status: NOT_YET_RECRUITING city: Tulsa state: Oklahoma zip: 74133 country: United States lat: 36.15398 lon: -95.99277 facility: Research Site status: NOT_YET_RECRUITING city: Grants Pass state: Oregon zip: 97527 country: United States lat: 42.43933 lon: -123.33067 facility: Research Site status: NOT_YET_RECRUITING city: Medford state: Oregon zip: 97504 country: United States lat: 42.32652 lon: -122.87559 facility: Research Site status: NOT_YET_RECRUITING city: Roseburg state: Oregon zip: 97471 country: United States lat: 43.2165 lon: -123.34174 facility: Research Site status: NOT_YET_RECRUITING city: Camp Hill state: Pennsylvania zip: 17011 country: United States lat: 40.23981 lon: -76.91997 facility: Research Site status: NOT_YET_RECRUITING city: DuBois state: Pennsylvania zip: 15801 country: United States lat: 41.11923 lon: -78.76003 facility: Research Site status: NOT_YET_RECRUITING city: Philadelphia state: Pennsylvania zip: 19140 country: United States lat: 39.95233 lon: -75.16379 facility: Research Site status: RECRUITING city: Anderson state: South Carolina zip: 29621 country: United States lat: 34.50344 lon: -82.65013 facility: Research Site status: NOT_YET_RECRUITING city: Charleston state: South Carolina zip: 29414 country: United States lat: 32.77657 lon: -79.93092 facility: Research Site status: NOT_YET_RECRUITING city: Columbia state: South Carolina zip: 29201 country: United States lat: 34.00071 lon: -81.03481 facility: Research Site status: RECRUITING city: Gaffney state: South Carolina zip: 29340 country: United States lat: 35.07179 lon: -81.64982 facility: Research Site status: NOT_YET_RECRUITING city: Spartanburg state: South Carolina zip: 29303 country: United States lat: 34.94957 lon: -81.93205 facility: Research Site status: RECRUITING city: Union state: South Carolina zip: 29379 country: United States lat: 34.71541 lon: -81.62371 facility: Research Site status: NOT_YET_RECRUITING city: North Sioux City state: South Dakota zip: 57049 country: United States lat: 42.52722 lon: -96.48309 facility: Research Site status: NOT_YET_RECRUITING city: Rapid City state: South Dakota zip: 57701 country: United States lat: 44.08054 lon: -103.23101 facility: Research Site status: NOT_YET_RECRUITING city: Chattanooga state: Tennessee zip: 37421 country: United States lat: 35.04563 lon: -85.30968 facility: Research Site status: NOT_YET_RECRUITING city: Elizabethton state: Tennessee zip: 37643 country: United States lat: 36.34872 lon: -82.21069 facility: Research Site status: NOT_YET_RECRUITING city: Franklin state: Tennessee zip: 37067 country: United States lat: 35.92506 lon: -86.86889 facility: Research Site status: NOT_YET_RECRUITING city: Morristown state: Tennessee zip: 37813 country: United States lat: 36.21398 lon: -83.29489 facility: Research Site status: RECRUITING city: Tullahoma state: Tennessee zip: 37388 country: United States lat: 35.36202 lon: -86.20943 facility: Research Site status: NOT_YET_RECRUITING city: Abilene state: Texas zip: 79606 country: United States lat: 32.44874 lon: -99.73314 facility: Research Site status: NOT_YET_RECRUITING city: Amarillo state: Texas zip: 79106 country: United States lat: 35.222 lon: -101.8313 facility: Research Site status: NOT_YET_RECRUITING city: Austin state: Texas zip: 78704 country: United States lat: 30.26715 lon: -97.74306 facility: Research Site status: NOT_YET_RECRUITING city: Brownsville state: Texas zip: 78520 country: United States lat: 25.90175 lon: -97.49748 facility: Research Site status: NOT_YET_RECRUITING city: Dallas state: Texas zip: 75225 country: United States lat: 32.78306 lon: -96.80667 facility: Research Site status: NOT_YET_RECRUITING city: Dallas state: Texas zip: 75235 country: United States lat: 32.78306 lon: -96.80667 facility: Research Site status: NOT_YET_RECRUITING city: Denison state: Texas zip: 75020 country: United States lat: 33.75566 lon: -96.53666 facility: Research Site status: NOT_YET_RECRUITING city: El Paso 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