hackint0sh/New-Dataset huggingface dataset:
Participants will be operated and have to attend follow-up visits with MRI after 6 months up to 5 years after surgery. conditions: Meniscus Lesion studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE maskingDescription: no masking, patient decides which group count: 40 type: ESTIMATED name: Spongioflex® name: non-operated measure: To evaluate efficacy of the procedure measure: Improvement of International Knee Documentation Committee (IKDC) score (between 0 and 100, the higher the better) measure: Improvement of Knee Injury and Osteoarthritis Outcome Score (KOOS) score (between 0 and 100, the higher the better) measure: Improvement of Visual Analogue Scale (VAS) Pain Score (between 0 and 10, the lower the better) measure: Safety of the patient (adverse events (AE) and serious adverse events (SAE)) measure: Efficacy of the procedure, progression to osteoarthrosis measure: Menuiscus size measure: extrusion of meniscus measure: Size of meniscal extrusion measure: Patient satisfaction sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Privatpraxis für Knie und Schulterchirurgie status: RECRUITING city: Dortmund zip: 44137 country: Germany name: Sven Behrendt, MD role: CONTACT phone: +49231 8626064 email: praxis@dr-sven-behrendt.de name: Sven Behrendt, MD role: PRINCIPAL_INVESTIGATOR lat: 51.51494 lon: 7.466 hasResults: False
nctId: NCT06376409 id: NW-HGN-02 briefTitle: Prospective Study of Nutraceutical Supplements to Support Hair Growth in Females overallStatus: NOT_YET_RECRUITING date: 2024-05-06 date: 2025-04-01 date: 2025-06-01 date: 2024-04-19 date: 2024-04-23 name: Nutraceutical Wellness Inc. class: INDUSTRY briefSummary: A single site open label interventional study evaluating currently marketed hair supplements targeting the underlying root causes of thinning hair. conditions: Hair Thinning studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single Group Assignment 6-month, single-center, prospective interventional study primaryPurpose: TREATMENT masking: NONE count: 180 type: ESTIMATED name: Nutrafol Women's Hair Growth Supplement name: Nutrafol Women's Balance Hair Growth Supplement name: Nutrafol Women's Vegan Hair Growth Supplement name: Nutrafol Women's Postpartum Hair Growth Supplement measure: The percent change in hair growth rate at Day 180 relative to baseline (Day 0) measure: The percent change in hair growth rate at Day 90 relative to baseline (Day 0) measure: The change in total hair count, terminal hairs, vellus hairs, anagen, and telogen hairs compared to baseline at 90 days measure: The change in total hair count, terminal hairs, vellus hairs, anagen, and telogen hairs compared to baseline at 180 days measure: The change in terminal to vellus ratio measure: The change in terminal to vellus ratio measure: The change in anagen to telogen ratio measure: The change in anagen to telogen ratio measure: The change in average number of hairs per follicular unit measure: The change in average number of hairs per follicular unit measure: The change in total hair width per cm2 measure: The change in total hair width per cm2 measure: The change in mean inter-follicular distance measure: The change in mean inter-follicular distance measure: Subjective assessments of change measured with Consumer Perception Questionnaire at 90 days measure: Subjective assessments of change measured with Consumer Perception Questionnaire at 180 days sex: FEMALE minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Integrative Skin Science and Research city: Sacramento state: California zip: 95815 country: United States name: Nasima Afzal role: CONTACT phone: 916-750-2463 lat: 38.58157 lon: -121.4944 hasResults: False
nctId: NCT06376396 id: 101103306 briefTitle: Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchymal Neurocysticercosis acronym: NeuroSolve overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2026-12 date: 2024-04-19 date: 2024-04-23 name: R-Evolution Worldwide S.r.l. Impresa Sociale class: OTHER name: Muhimbili University of Health and Allied Sciences name: National Institute for Medical Research, Tanzania name: Sokoine University of Agriculture name: University of Zambia name: University Ghent briefSummary: The goal of this clinical trial is to compare the combination albendazole and praziquantel versus albendazole alone in patients affected by neurocysticercosis. conditions: Neurocysticercosis studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 300 type: ESTIMATED name: albendazole and praziquantel name: Albendazole measure: Cyst resolution or reduction in both study arms measure: Seizures frequency measure: Quality of Life questionnaire measure: Headache measure: Serological test results correlation with neuroimaging results sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06376383 id: TETT-RHG id: 110500 type: OTHER domain: The Central Denmark Region Committees on Health Research Ethics briefTitle: Tonsillectomy vs. Tonsillotomy in Adults With Obstructive Sleep Apnea overallStatus: NOT_YET_RECRUITING date: 2025-01 date: 2026-12 date: 2027-09 date: 2024-04-19 date: 2024-04-19 name: University of Aarhus class: OTHER briefSummary: The primary purpose of this randomized controlled trial s to investigate whether surgical reduction of palatine tonsils (tonsillotomy) is a superior treatment compared to complete surgical removal of palatine tonsils (tonsillectomy) in adults patients with obstructive sleep apnea and concomitant enlarged tonsils in regards of perioperative and postoperative morbidity. conditions: Obstructive Sleep Apnea conditions: Tonsillar Hypertrophy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 464 type: ESTIMATED name: Tonsillectomy name: Tonsillotomy measure: Postoperative hemorrhage measure: Postoperative pain measure: Recovery time - Sick leave measure: Morbidity measure: AHI measure: DISE - VOTE sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06376370 id: 16.04.24/2 briefTitle: The Effect of a Computer-Assisted Rehabilitation Program on Epilepsy Patient overallStatus: ENROLLING_BY_INVITATION date: 2024-04-26 date: 2024-06-10 date: 2024-07-28 date: 2024-04-19 date: 2024-04-19 name: Selcuk University class: OTHER briefSummary: The aim of this study is to examine the effects of the RehaCom Computer-Assisted Rehabilitation Program Applied to Epilepsy Patients on Self-Management, Cognitive Function and Quality of Life. conditions: Epilepsy conditions: Computer-assisted Cognitive Rehabilitation conditions: Quality of Life studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: INVESTIGATOR count: 50 type: ESTIMATED name: Application of computer-assisted cognitive rehabilitation program measure: Mini Mental State Test measure: Epilepsy Quality of Life Scale measure: MOXO Test measure: Epilepsy Self-Management Scale sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: ülkü Saygili Düzova city: Selçuklu state: Konya country: Turkey lat: 37.8842 lon: 32.49222 hasResults: False
nctId: NCT06376357 id: 16.04.24/1 briefTitle: The Effect of Foot Massage With Roles on Cancer Patients overallStatus: ENROLLING_BY_INVITATION date: 2024-04-27 date: 2024-06-15 date: 2024-07-30 date: 2024-04-19 date: 2024-04-19 name: Selcuk University class: OTHER briefSummary: It was aimed to examine the roles in the management of treatment-related peripheral neuropathy in cancer patients receiving taxane-based chemotherapy and the effect of foot massage on neuropathy and quality of life. conditions: Breast Neoplasms conditions: Over Cancer conditions: Foot Massage studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: INVESTIGATOR count: 54 type: ESTIMATED name: Foot Massage with roller measure: EORTC QLQ C-30 Quality of Life Scale measure: CIPN20 Neuropathy Scale measure: One Leg Standing Test measure: Brief Pain Inventory BPI measure: Pain Threshold Assessment Test measure: Two Point Discrimination sex: FEMALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ülkü Saygili Düzova city: Selçuklu state: Konya country: Turkey lat: 37.8842 lon: 32.49222 hasResults: False
nctId: NCT06376344 id: 16.04.24 briefTitle: The Effect of Tennis Ball on Balance and Quality of Life in Cancer Patients With Neuropathy. overallStatus: ENROLLING_BY_INVITATION date: 2024-04-28 date: 2024-06-10 date: 2024-07-10 date: 2024-04-19 date: 2024-04-19 name: Selcuk University class: OTHER briefSummary: This research; It was aimed to evaluate the effect of myofascial release using a tennis ball on balance and quality of life in cancer patients who developed peripheral neuropathy. conditions: Cancer conditions: Neuropathy conditions: Therapy-Associated Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: INVESTIGATOR count: 50 type: ESTIMATED name: myofascial release with tennis ball measure: EORTC QLQ C-30- CIPN20 Scale measure: One Leg Standing Test measure: Lateral Reach Test measure: Pain Assessment measure: Pressure Pain Threshold Assessment measure: Two Point Discrimination sex: ALL minimumAge: 25 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ülkü Saygili Düzova city: Selçuklu state: Konya country: Turkey lat: 37.8842 lon: 32.49222 hasResults: False
nctId: NCT06376331 id: ADHD20240403 briefTitle: Washed Microbiota Transplantation for Attention-deficit/Hyperactivity Disorder overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2027-06-01 date: 2027-07-01 date: 2024-04-19 date: 2024-04-24 name: The Second Hospital of Nanjing Medical University class: OTHER name: SIR RUN RUN hospital of Nanjing Medical University briefSummary: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention and hyperactivity-impulsivity. ADHD is often accompanied by oppositional defiant disorder and sleep disturbance, and can increase the risk of other psychiatric disorders, functional impairment in academic and occupational performance. Recently, gut microbiota has been implicated in the ADHD via gut-brain axis. In this study, investigators aimed to evaluate the efficacy of WMT for core ADHD symptoms and its comorbidities using specialized questionnaires for ADHD and investigate the underlying mechanism. conditions: Attention-deficit/Hyperactivity Disorder studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: washed microbiota transplantation measure: change of Swanson, Nolan and Pelham-IV (SNAP-IV). measure: change of Chinese version of the Conners abbreviated symptom questionnaire (C-ASQ). measure: change of the Sleep Disturbance Scale for Children (SDSC). measure: change of the Gastrointestinal Symptom Rating Scale (GSRS) . measure: the difference of the gut microbe composition between children with ADHD and healthy children by sequencing faecal metagenome. measure: the difference of the serum neurotransmitters between children with ADHD and healthy children measure: intestinal barrier sex: ALL minimumAge: 6 Years maximumAge: 17 Years stdAges: CHILD facility: Department of Microbiota Medicine & Medical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University city: Nanjing state: Jiangsu country: China name: Faming Zhang, PhD role: CONTACT phone: 086-025-58509883 email: fzhang@njmu.edu.cn lat: 32.06167 lon: 118.77778 facility: SIR RUN RUN hospital of Nanjing Medical University city: Nanjing state: Jiangsu country: China lat: 32.06167 lon: 118.77778 hasResults: False
nctId: NCT06376318 id: 19-138 briefTitle: Shock and Acute Conditions OutcOmes Platform acronym: ShockCO-OP overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-01 date: 2025-07-01 date: 2026-01-01 date: 2024-04-19 date: 2024-04-19 name: Saint-Louis Hospital, Paris, France class: OTHER name: University of Helsinki name: University of Ottawa name: University of Leipzig name: University of Nancy name: McGill University name: Mayo Clinic name: University of Paris 5 - Rene Descartes name: University of Toronto briefSummary: In-hospital mortality of patients admitted in the intensive care unit (ICU) for circulatory shock remains high (between 20 and 40%).
This will enable an improvement in risk prediction and a better patient selection in future clinical trials to assess a personalized therapy (i.e., prospective enrollment based on a biological/molecular signature). conditions: Circulatory Shock conditions: Sepsis conditions: Cardiogenic Shock conditions: Major Trauma conditions: Surgical Shock studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 1000 type: ESTIMATED name: Inotrope name: Mechanical circulatory support name: anti-bodies measure: Mortality rate measure: Mortality rate measure: Renal replacement therapy use rate measure: Mechanical circulatory support use rate measure: Vasopressors and inotropes-free days sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: St Michael's Hospital city: Toronto state: Ontario zip: M5B 1W8 country: Canada lat: 43.70011 lon: -79.4163 hasResults: False
nctId: NCT06376292 id: Y⒛24-0106 briefTitle: A Prospective Study of Whole-Brain RT Combined With Thiotepa Sheath Injection Combined With Systemic Therapy for the Primary Disease in the Treatment of Meningeal Metastases in Solid Tumors overallStatus: RECRUITING date: 2024-02-01 date: 2026-02-01 date: 2026-02-01 date: 2024-04-19 date: 2024-04-19 name: Second Affiliated Hospital, School of Medicine, Zhejiang University class: OTHER briefSummary: The goal of this prospective, single-arm exploratory clinical study is to explore the safty and efficacy of whole-brain radiotherapy combined with Thiotepa sheath injection combined With Systemic Therapy for the Primary Disease in the Treatment of Meningeal Metastases in Solid Tumors
Researchers will evaluate whether this combination treatment is safe and whether it is more effective than previous studies. conditions: Solid Tumor Leptomeningeal Metastasis studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Participants will receive a comprehensive treatment plan consisting mainly of whole brain 30Gy/10F radiotherapy combined with intrathecal injection of Thiotepa twice a week for a total of 4 weeks. primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Intrathecal Injection of Thiotepa+Radiation+Systemic Treatment of Primary Diseases measure: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability] measure: OS measure: 3-month PFS measure: 6-month PFS measure: 1-year PFS sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Second Affiliated Hospital of Zhejiang University status: RECRUITING city: Hangzhou state: Zhejiang zip: 310000 country: China name: Ting Zhang, Prof. role: CONTACT phone: +8615157125533 email: zezht@zju.edu.cn lat: 30.29365 lon: 120.16142 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2024-03-12 uploadDate: 2024-03-13T09:04 filename: Prot_000.pdf size: 320618 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-03-12 uploadDate: 2024-03-13T09:05 filename: ICF_001.pdf size: 156721 hasResults: False
nctId: NCT06376279 id: 2008/351-31 briefTitle: Genetic Diagnosis in Inborn Errors of Metabolism overallStatus: ENROLLING_BY_INVITATION date: 2008-04-29 date: 2030-12-31 date: 2030-12-31 date: 2024-04-19 date: 2024-04-19 name: Region Stockholm class: OTHER_GOV name: Karolinska Institutet briefSummary: Inborn Errors of metabolism comprise a large number of rare conditions with a collective incidence of around 1/2000 newborns. Many disorders are treatable provided that a correct diagnosis can be established in time, and for many diseases novel therapies are being developed. Without treatment, many of the conditions result in early death or severe irreversible handicaps.
The Centre for Inherited Metabolic Diseases, CMMS at Karolinska university hospital, is an integrated expert center where clinical specialists work closely together with experts in laboratory medicine, combining clinical genetics, clinical chemistry, pediatrics, neurology, and endocrinology. The center serves the whole Swedish population with diagnostics and expert advice on IEM and has a broad arsenal of biochemical investigations designed to detect defects in intermediary metabolism. conditions: Metabolic Disease conditions: Mitochondrial Diseases conditions: Epilepsy in Children conditions: Epilepsy conditions: LHON conditions: Motor Neuron Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 1000 type: ESTIMATED name: IEM-EP measure: Genetic variant identification using NGS for diagnosis sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06376266 id: 202305083RSC briefTitle: Assessment of the Intervention Effectiveness of Branched-chain Amino Acids(BCAA) Combined With Medium-chain Fatty Acid(MCFA) Products in Sarcopenia Among Middle-aged and Elderly Individuals overallStatus: RECRUITING date: 2023-10-01 date: 2023-12-29 date: 2024-09-30 date: 2024-04-19 date: 2024-04-19 name: National Taiwan University Hospital class: OTHER briefSummary: Taiwan entered an aging society in 2018 and is expected to transition into a super-aged society by 2025. With the increasing elderly population, age-related diseases pose urgent challenges to modern society. According to the Ministry of Health and Welfare's National Health Statistics in 2018, the prevalence of sarcopenia in Taiwan among individuals aged 65 and older is 23.6% for males and 18.6% for females. Sarcopenia, characterized by the loss of skeletal muscle mass due to aging, coupled with decreased muscle strength and/or reduced physical performance, poses a significant risk for disability, decreased quality of life, and increased mortality.
Existing research indicates that appropriate nutrition and exercise can slow the onset of sarcopenia and even increase muscle mass to reverse its effects. This study is an interventional clinical trial recruiting middle-aged and elderly patients with sarcopenia or pre-sarcopenia. The intervention involves a combination of branched-chain amino acids and medium-chain triglyceride products, and the study aims to assess the effectiveness of this intervention for sarcopenia in middle-aged and elderly individuals. conditions: Sarcopenia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 80 type: ESTIMATED name: nutritional supplements measure: the scale of sarcopenia measure: the scale of sarcopenia measure: the scale of sarcopenia sex: ALL minimumAge: 50 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Geriatrics and Gerontology, National Taiwan University Hospital status: RECRUITING city: Taipei zip: 100 country: Taiwan name: Ding-cheng Chan, DR role: CONTACT phone: +886-2-23123456 phoneExt: 67095 email: dingchengchan@ntu.edu.tw lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06376253 id: CGIZ943A12101 id: 2023-507674-41-00 type: OTHER domain: CTIS briefTitle: A Phase I Study of [177Lu]Lu-EVS459 in Patients With Ovarian and Lung Cancers overallStatus: NOT_YET_RECRUITING date: 2024-09-06 date: 2030-08-30 date: 2030-08-30 date: 2024-04-19 date: 2024-04-19 name: Novartis Pharmaceuticals class: INDUSTRY briefSummary: The purpose of this study is to evaluate the safety, tolerability, dosimetry and preliminary efficacy of \[177Lu\]Lu-EVS459 and the safety and imaging properties of \[68Ga\]Ga-EVS459 in patients aged ≥ 18 years with advanced high-grade serous ovarian cancer (OC) or locally advanced unresectable or metastatic non-squamous non-small cell lung carcinoma (non-sq. NSCLC). conditions: Ovarian Cancer conditions: Lung Cancer studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 96 type: ESTIMATED name: [68Ga]Ga-EVS459 name: [177Lu]Lu-EVS459 measure: Number of participants with dose limiting toxicities of [177Lu]Lu-EVS459 measure: Incidence and severity of adverse events and serious adverse events of [177Lu]Lu- EVS459 measure: Dose modifications for [177Lu]Lu- EVS459 measure: Dose intensity for [177Lu]Lu- EVS459 measure: Overall response rate (ORR) measure: Duration of Response (DOR) measure: Disease control rate (DCR) measure: Progression free survival (PFS) measure: Area Under the Curve (AUC) of [177Lu]Lu-EVS459 measure: Total body clearance of [177Lu[Lu-EVS459 measure: Observed maximum plasma concentration (Cmax) of [177Lu]Lu-EVS459 measure: Volume of distribution during the terminal phase following intravenous elimination (Vz) of [177Lu]Lu-EVS459 measure: Terminal elimination half-life (T1/2) of [177Lu]Lu-EVS459 measure: Urinary excretion of radioactivity expressed as a percentage of injected activity (%IA) measure: Renal clearance of [177Lu]Lu- EVS459 measure: Absorbed dose of [177Lu]Lu- EVS459 measure: Time-activity curves (TACs) related to [177Lu]Lu-EVS459 uptake in organs and tumor lesions measure: Incidence and severity of adverse events and serious adverse events of [68Ga]Ga-EVS459 measure: Visual and quantitative assessment of [68Ga]Ga-EVS459 uptake in normal tissues and tumor lesions over time sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False