hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06311630 id: 65/23/IEC/JMMC&RI briefTitle: Comparative Study of Analgesic Effect of Ultrasound Guided PENG Block vs FEMORAL BLOCK in Hip Fracture overallStatus: RECRUITING date: 2023-05-20 date: 2025-01-20 date: 2025-03-20 date: 2024-03-15 date: 2024-03-15 name: Jubilee Mission Medical College and Research Institute class: OTHER briefSummary: To study the analgesic effect of ultrasound guided PENG Block vs Femoral nerve block in patients with Hip fracture presenting to Emergency department conditions: Hip Fracture studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 70 type: ESTIMATED measure: Comparative Study of Analgesic Effect of Ultrasound Guided PENG Block With FEMORAL NERVE BLOCK in Patients With Hip Fracture as assessed by NRS pain scoring scale by patient measure: Time taken for each technique measure: Time taken for adequate analgesia measure: Incidence of complications measure: To note if rescue analgesic is required sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Jubilee mission medical College and research centre status: RECRUITING city: Thrissur state: Kerala zip: 680005 country: India name: Jogi Varghese, MBBS role: CONTACT phone: 9947004222 email: jogi1907@gmail.com lat: 10.51667 lon: 76.21667 hasResults: False
nctId: NCT06311617 id: 231592 briefTitle: Retinal Vascular Changes During Pregnancy overallStatus: RECRUITING date: 2024-02-01 date: 2027-01 date: 2027-01 date: 2024-03-15 date: 2024-03-15 name: Vanderbilt University Medical Center class: OTHER briefSummary: The goal of this study is to better understand how the back part of the eye-called the retina and the choroid-changes during pregnancy. Specialized photos of the eye will be taken at three different timepoints: early in pregnancy (first or second trimester), late in pregnancy (third trimester), and after delivery. This imaging is non-invasive and does not require contact with the surface of the eye. The photos taken will allow assessment of specific parameters, like blood flow and the health of specialized cells that support vision. Understanding how the eyes change during pregnancy may help guide how retina specialists understanding of retinal disease during pregnancy and better inform pregnancy outcomes. conditions: Pregnancy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 90 type: ESTIMATED name: Fundus photography and optical coherence tomography measure: Imaging Biomarkers: Choroid measure: Imaging Biomarkers: Vessel density measure: Imaging Biomarkers: Foveal avascular zone (FAZ) measure: Fetal Health: delivery measure: Fetal Health sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Vanderbilt University Medical Center status: RECRUITING city: Nashville state: Tennessee zip: 37232 country: United States name: Avni Finn, MD, MBA role: CONTACT phone: 615-936-1639 lat: 36.16589 lon: -86.78444 hasResults: False
nctId: NCT06311604 id: 38RC22.0272 briefTitle: Evaluation of the Safety of Inhaled Sedation With Isoflurane in Head Trauma Patients acronym: IsoSAFE overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-12-01 date: 2024-03-15 date: 2024-03-15 name: University Hospital, Grenoble class: OTHER briefSummary: Intensive care management of patient with severe traumatic brain injury (TBI) includes deep and prolonged sedation with intravenous hypnotics (propofol, midazolam, ketamine) in combination with opioids to prevent and/or treat episodes of intracranial hypertension. However, some patients may develop tachyphylaxis with a gradual increase of administered intravenous hypnotics and opioids to maintain the same level of sedation. This situation leads to a failure in controlling intracranial pressure (ICP) and/or to the risk of adverse effects due to high-dose sedatives: haemodynamic instability, prolonged mechanical ventilation, neuromyopathy, delirium, withdrawal syndrome.
Halogenated agents (Isoflurane, Sevoflurane) are a class of hypnotics routinely used in the operating room. However, doses used in surgical patients (\> 1 Minimal Alveolar Concentration, MAC) are not suitable in neuro-intensive care unit (ICU) patients at risk of intracranial hypertension because of the cerebral vasodilator effects of halogenated agents at this dosage, hence the risk of high ICP and compromised cerebral perfusion pressure.
The use of halogenated agents has been recently possible in the ICU through dedicated medical devices (Sedaconda ACD, Mirus). Recommended dosage are lower in the ICU, i.e. 0.3-0.7 MAC, because of their association with intravenous hypnotics and the absence of surgical stimuli. Several clinical studies in general ICUs showed improved sedation quality, reduced duration of mechanical ventilation, faster arousal and shorter extubation time, and lower costs in halogenated group compared with control group receiving midazolam or propofol. At low doses, the effects on ICP and intracerebral haemodynamics of halogenated agents are minor according to the available literature. In addition, beneficial effects were found on cerebral ischaemic volume in animal models treated with halogenated agents. However, there is a need to explore the benefit-risk ratio of the use of halogenated agents in the severe TBI population.
The investigator hypothesise that 0.7 MAC Isoflurane can be administered in this population without deleterious effect on ICP. conditions: Traumatic Brain Injury studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Prospective, open-label, single-centre, interventional dose escalation study primaryPurpose: OTHER masking: NONE count: 30 type: ESTIMATED name: Isoflurane measure: To assess the safety of sedation with 0.7 MAC of inhaled isoflurane in cranial trauma patients in terms of intracranial pressure. measure: To assess the effect on cerebral blood flow of inhaled isoflurane sedation in patients with cranial trauma. measure: To assess the effect on cerebral blood flow of inhaled isoflurane sedation in patients with cranial trauma. measure: To assess the effect on cerebral blood flow of inhaled isoflurane sedation in patients with cranial trauma. measure: To assess the effect on cerebral blood flow of inhaled isoflurane sedation in patients with cranial trauma. measure: To assess the extra-neurological effects of inhaled isoflurane sedation in head trauma patients measure: To assess the extra-neurological effects of inhaled isoflurane sedation in head trauma patients measure: To assess the extra-neurological effects of inhaled isoflurane sedation in head trauma patients measure: To assess the savings in intravenous hypnotics associated with isoflurane inhalation sedation in head trauma patients measure: To assess the feasibility of inhaled sedation with isoflurane in patients with head trauma measure: To assess the neurological outcome at D28 after inhaled sedation in head trauma patients sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Grenoble city: Grenoble state: Choisir Une Région zip: 38043 country: France name: barthélémy H Grenoble, MD role: CONTACT phone: +33476766879 email: bbertrand4@chu-grenoble.fr name: Anais ADOLLE role: CONTACT phone: +33476766879 email: aadolle@chu-grenoble.fr lat: 45.16667 lon: 5.71667 hasResults: False
nctId: NCT06311591 id: STUDY00000716 Part B id: 1P50MH129701 type: NIH link: https://reporter.nih.gov/quickSearch/1P50MH129701 briefTitle: Efficacy, Effectiveness, and Implementation of Jaspr Health in Emergency Department- Part B acronym: Jaspr-PartB overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-04-01 date: 2027-04-01 date: 2024-03-15 date: 2024-03-28 name: University of Massachusetts, Worcester class: OTHER name: Ohio State University name: University of Colorado, Denver name: Evidence-Based Practice Institute, Seattle, WA name: National Institute of Mental Health (NIMH) name: Worcester Polytechnic Institute briefSummary: This Study will evaluate the implementation of a multi-component suicide prevention technology (Jaspr Health) that facilitates delivery of suicided-related evidence-based practices (EBPs) while replacing wasted waiting time with productive time in the Emergency Departments (EDs). The EBPs satisfy several key performance elements for systems adopting Zero Suicide.
A Complementary Randomized Controlled Trial and Real-World Study for Efficacy, Effectiveness, and Implementation Study Design (CREID) will be used conditions: Suicidal Ideation conditions: Suicide Attempt conditions: Self Harm studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 27908 type: ESTIMATED name: Jaspr App measure: Suicide composite, binary measure: Evidence-Based Practice (EBP) delivery measure: Patient reach measure: Fidelity measure: Exposure, Time measure: Costs measure: Clinician acceptability measure: Patient acceptability measure: Feasibility of Jaspr in ED measure: Usability (clinician) measure: System workflow impact, door to behavioral health evaluation measure: System workflow impact, total length of stay measure: System workflow impact, 28 day revisit measure: System workflow impact, clinician perception sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UCHealth University of Colorado Hospital city: Aurora state: Colorado zip: 80045 country: United States name: Marian Betz, MD role: CONTACT email: marian.betz@cuanschutz.edu lat: 39.72943 lon: -104.83192 facility: UCHealth Memorial Hospital Central city: Colorado Springs state: Colorado zip: 80909 country: United States name: Marian Betz, MD role: CONTACT email: marian.betz@cuanschutz.edu lat: 38.83388 lon: -104.82136 facility: Ohio State East Hospital city: Columbus state: Ohio zip: 43210 country: United States name: Michael S Lyons, MD role: CONTACT email: michael.lyons@osumc.edu lat: 39.96118 lon: -82.99879 facility: The Ohio State University Wexner Medical Center city: Columbus state: Ohio zip: 43210 country: United States name: Michael S Lyons, MD role: CONTACT email: michael.lyons@osumc.edu lat: 39.96118 lon: -82.99879 hasResults: False
nctId: NCT06311578 id: 87704916LUC1001 id: 2023-506495-27-00 type: REGISTRY domain: EUCT number briefTitle: A Study of JNJ-87704916, as Monotherapy and in Combination for Advanced Solid Tumors overallStatus: RECRUITING date: 2024-04-10 date: 2028-11-08 date: 2033-11-30 date: 2024-03-15 date: 2024-04-25 name: Johnson & Johnson Enterprise Innovation Inc. class: INDUSTRY briefSummary: The purpose of this study is to determine the safety, feasibility, recommended dose(s) and regimen(s) of JNJ-87704916 as monotherapy and in combination with cetrelimab. conditions: Advanced Solid Tumors studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 66 type: ESTIMATED name: JNJ-87704916 name: Cetrelimab measure: Part 1: Number of Participants with Dose-Limiting Toxicity (DLT) measure: Number of Participants with Adverse Events (AEs) by Severity measure: Parts 1 and 2: Percentage of Participants With Objective Response (OR) measure: Parts 1 and 2: Percentage of Participants With Disease Control (DC) measure: Parts 1 and 2: Duration of Response (DOR) measure: Part 2: Progression Free Survival (PFS) measure: Part 2: Overall Survival (OS) measure: Parts 1 and 2: Number of JNJ-87704916 Genome Copies per Milliliter measure: Parts 1 and 2: Payload Concentrations of JNJ-87704916 measure: Parts 1 and 2: Number of Participants with JNJ-87704916 Antibodies sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: MD Anderson Cancer Center status: RECRUITING city: Houston state: Texas zip: 77030 country: United States lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06311565 id: SBU-ISTANBUL-0001 briefTitle: Effects of Education After Colorectal Cancer Screening overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2024-10-30 date: 2024-12-30 date: 2024-03-15 date: 2024-03-15 name: Istanbul Saglik Bilimleri University class: OTHER briefSummary: The aim of this study is to examine the effect of the education given to individuals undergoing colorectal cancer screening on their attitudes, beliefs and healthy lifestyle behaviors.
Patient Diagnosis Form, Colorectal Cancer Screening Attitude Belief Scale, Healthy Lifestyle Behavior Scale II will be used to collect data. Data will be collected at the first encounter, 1 month later, 3 months later, pre-test and post-test. In the research, individuals will be divided into two groups: intervention (n = 35) and control (n = 35). Training will be provided to the intervention group. conditions: Healthy Lifestyle conditions: Education studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized controlled ( experimental and control group) primaryPurpose: PREVENTION masking: SINGLE whoMasked: PARTICIPANT count: 70 type: ESTIMATED name: Education measure: Colorectal cancer screening attitude belief scale measure: Healthy lifestyle behaviors scale II sex: ALL minimumAge: 50 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hilal KARTAL city: Istanbul state: Beylikdüzü country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06311552 id: 0856 briefTitle: Optimising CMR Scan Acquisitions for Novel Equipment/Sequences in Clinical Cardiovascular Populations. acronym: OPTMISE-HFpEF overallStatus: COMPLETED date: 2022-01-31 date: 2023-11-30 date: 2023-11-30 date: 2024-03-15 date: 2024-03-15 name: University of Leicester class: OTHER briefSummary: The purpose of this study is to develop robust protocols for the optimisation of novel hardware, software and exercise equipment in the magnetic resonance imaging (MRI) environment in various cohorts with cardiovascular disease (CVD) with the first study focusing on those with established heart failure with preserved ejection fraction (HFpEF) or those at risk of or with pre-HFpEF. conditions: Heart Failure With Preserved Ejection Fraction studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 30 type: ACTUAL name: Participants will undergo a comprehensive CMR scan on either a 1.5- or 3-Tesla scanner measure: To develop CMR scanning protocols which acquire the highest quality images during incremental exercise using a stepper ergometer (Ergospect Cardio-stepper). measure: To determine the reproducibility of the exercise CMR protocols in a test-retest reproducibility sub-study measure: To determine the optimal scan acquisition protocol for Magnetic Resonance Spectroscopy (MRS) both H+ and 31P using the phosphorous coil in each patient group. measure: To determine the reproducibility of the MRS protocols in a test-retest reproducibility sub-study sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Glenfield Hospital city: Leicester country: United Kingdom lat: 52.6386 lon: -1.13169 hasResults: False
nctId: NCT06311539 id: IstanbulBUFC4 briefTitle: The Effect of Circadian Rhythm on Physical Performance in Healthy Male Individuals overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-08-01 date: 2024-10-01 date: 2024-03-15 date: 2024-03-15 name: Istanbul Bilgi University class: OTHER briefSummary: Little is known about optimizing the timing of exercise periods to maximize the health benefits of exercise. Furthermore, exercise is a potent modulator of skeletal muscle metabolism and it is clear that skeletal muscle has a robust circadian profile. Circadian rhythms can be observed in behavior, physiology, and metabolism. Various studies show that exercise changes the rhythm of the clock machines in skeletal muscle. Studies examining the relationship between exercise, especially strength training, and circadian rhythm are quite limited in the literature. Although some studies have shown that force peaks in the afternoon/evening hours, regardless of muscle group and contraction speed, there are no studies on how much this time interval varies from person to person and chronotype.
The aim of this study is to investigate to what extent strength training given at appropriate times for morning, evening and intermediate chronotypes creates changes in performance in healthy adult male individuals. conditions: Chronotype conditions: Exercise studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized Controlled Study primaryPurpose: SCREENING masking: SINGLE maskingDescription: The evaluator who will perform isokinetic assessments and vertical jump measurements will be blinded to the participants' chronotype. whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Theraband Strengthening Exercise Program measure: Isokinetic strength test measure: Vertical jump test sex: MALE minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT hasResults: False
nctId: NCT06311526 id: 24C303 briefTitle: Mechanism of Action of Focal Extracorporeal Shock Waves as a Treatment of Upper Limb Stroke Spasticity: a Pilot Study acronym: SASHA overallStatus: RECRUITING date: 2023-05-30 date: 2025-04-30 date: 2025-04-30 date: 2024-03-15 date: 2024-03-15 name: Istituto Auxologico Italiano class: OTHER briefSummary: Spasticity, common after a stroke, aggravates the patient's motor impairment causing pain and limitation in daily activities such as eating, dressing and walking.
Clinical improvement is also expected to be associated with an improvement in the following neurophysiological parameters: a reduction of the H/Mmax ratio (an index of hyperexcitability of the monosynaptic stretch reflex circuit), a decrease in amplitude of the F waves (a neurophysiological signal reflecting the excitability of single/restricted motoneurones) and an increase of the homosynaptic depression (also known as post-activation depression, reflecting the excitability of the transmission between the Ia fibres and motoneurones).
On the contrary, if the shock waves work on spasticity by indirectly acting on the nervous system's excitability, then a neurophysiology study could be used to preliminary identify the muscle groups with the most significant neurophysiological alterations, which could be the muscles benefitting the most from this treatment. conditions: Stroke conditions: Hemiparesis conditions: Hemiplegia conditions: Spasticity as Sequela of Stroke conditions: Upper Limb Hypertonia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 12 type: ESTIMATED name: Extracorporeal Shockwave Therapy measure: M wave and H reflex recruitment curve measure: H reflex post-activation depression measure: F waves measure: T reflex measure: Upper limb dexterity measures measure: Ultrasound arm and forearm assessment sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Istituto Auxologico Italiano status: RECRUITING city: Milano state: MI zip: 20122 country: Italy name: Antonio Caronni, MD, PhD role: CONTACT phone: 02 619111 email: a.caronni@auxologico.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06311513 id: 2023-1017 id: 1177535 type: OTHER_GRANT domain: Arthritis Foundation briefTitle: Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-12 date: 2028-12 date: 2024-03-15 date: 2024-03-15 name: Hospital for Special Surgery, New York class: OTHER name: Emory University name: Arthritis Foundation briefSummary: The goal of this pilot randomized clinical trial is to look into the efficacy of concentrated bone marrow aspirate (cBMA) in improving post traumatic osteoarthritis (PTOA) symptoms in patients undergoing revision anterior cruciate ligament reconstruction surgery. The main questions it aims to answer are whether clinical outcomes, such as pain, are improved in patients who get cBMA with surgery, if there is a change in circulating markers of inflammation and what part of the cellular and molecular composition of cBMA may explain its effects. conditions: Anterior Cruciate Ligament Injuries conditions: Post-Traumatic Osteoarthritis of Knee conditions: Bone Marrow Aspirate Concentrate conditions: ACL Injury studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a single-blinded randomized controlled trial. Participants will be allocated to either:
2. Control arm (Revision ACLR + Sham Incision) primaryPurpose: PREVENTION masking: SINGLE whoMasked: PARTICIPANT count: 40 type: ESTIMATED name: Concentrated Bone Marrow Aspirate Injection name: Sham Incision name: Revision Anterior Cruciate Ligament Reconstruction measure: Change from baseline in patient reported knee pain measure: Expression of local inflammatory biomarkers measure: Concentration of circulating inflammatory biomarkers measure: Change from baseline in cartilage morphology measure: Change from baseline in articular cartilage relative proteoglycan content and collagen fibril organization sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Emory Orthopaedics & Spine Center city: Atlanta state: Georgia zip: 30097 country: United States lat: 33.749 lon: -84.38798 facility: Hospital for Special Surgery city: New York state: New York zip: 10021 country: United States name: Daniel de la Huerta, MD role: CONTACT phone: 212-606-1000 phoneExt: 2603159 email: delahuertamezad@hss.edu name: Miguel Otero, Ph.D. role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06311500 id: STUDY00151143 briefTitle: Sleep Health Enhancement in Midlife Adults overallStatus: RECRUITING date: 2024-02-13 date: 2025-06-30 date: 2025-06-30 date: 2024-03-15 date: 2024-03-15 name: University of Kansas Medical Center class: OTHER briefSummary: Despite the strong links between sleep and AD, a sleep health enhancement has yet to be targeted in mid-life adults (45-64 years old) to delay or prevent AD. An intervention aimed at enhancing sleep health is a critical opportunity for primary prevention to potentially delay the onset of AD. The objective of the proposed study is to develop and assess the feasibility, acceptability, and treatment effect of a comprehensive sleep health intervention (SHI) on improving sleep health in mid-life adults conditions: Sleep Health conditions: Midlife Adults studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: Sleep health enhancement intervention measure: 6-item Acceptability Scale measure: Qualitative interview measure: Ru-SATED Composite score measure: Sleep Self-Efficacy Scale measure: Pittsburgh Sleep Quality Index measure: Epworth Sleepiness Scale measure: Dysfunctional Beliefs About Sleep (DBAS-10) consists of 10 statements reflecting beliefs and attitudes about sleep. Each statement is rated from 1 = strongly disagree to 10 = strongly agree measure: Positive Affect and Negative Affect Schedule measure: Continuous Performance Test measure: Stroop Test measure: Cognitive Failures Questionnaire measure: Actigraphy sex: ALL minimumAge: 45 Years maximumAge: 64 Years stdAges: ADULT facility: University of Kansas Medical Center status: RECRUITING city: Kansas City state: Kansas zip: 66160 country: United States lat: 39.11417 lon: -94.62746 hasResults: False