hackint0sh/New-Dataset huggingface dataset:
Similar to differences in cardiovascular disease (CVD) rates across racial and ethnic groups of older people, there are differences in engagement in physical activity (PA), a significant contributor to CVD. Black adults are less likely to engage in physical activity PA than their non-Hispanic White peers, with 26.7% of Black Minnesotans reporting that they did not engage any leisure-time PA in the past month, compared to 19.6% of non-Hispanic White Minnesotans. Notably, recent research has demonstrated that high amounts SB (i.e., sitting or lying with low levels of energy expenditure) also have significant detrimental effects on health, beyond those of physical inactivity. Experimental data from lab-based studies demonstrate that breaking up prolonged SB can rapidly improve markers of cardiometabolic risk (e.g., glucose and endothelial function) but the majority of these studies have focused on young, healthy, White adults. Given the significant inequities and health disparities faced by Black individuals and the lack of adequate representation of Black older adults in studies examining SB in individuals with T2D, understanding psychosocial and societal contributors to and consequences of SB experienced by this population is an essential first step toward developing relevant interventions targeting SB, and ultimately, CV health.
Similar to differences in CVD rates across racial and ethnic groups of older people, there are differences in engagement in physical activity (PA), a significant contributor to CVD. Black adults are less likely to engage in PA than their non-Hispanic White peers, with 26.7% of Black Minnesotans reporting that they did not engage any leisure-time PA in the past month, compared to 19.6% of non-Hispanic White Minnesotans. Notably, recent research has demonstrated that high amounts SB (i.e., sitting or lying with low levels of energy expenditure) also have significant detrimental effects on health, beyond those of physical inactivity. Experimental data from lab-based studies demonstrate that breaking up prolonged SB can rapidly improve markers of cardiometabolic risk (e.g., glucose and endothelial function) but the majority of these studies have focused on young, healthy, White adults. Given the significant inequities and health disparities faced by Black individuals and the lack of adequate representation of Black older adults in studies examining SB in individuals with T2D, understanding psychosocial and societal contributors to and consequences of SB experienced by this population is an essential first step toward developing relevant interventions targeting SB, and ultimately, CV health.
The goal is to develop a deeper understanding of individuals' experiences of sedentary behavior (SB) and collaborate to design strategies to reduce SB. Using the Center for Chronic Disease Reduction and Equity Promotion Across Minnesota (C2DREAM) conceptual model, social-ecological framework, and COM-B model, the study will seek to understand the relationship between SB and individual, relationship, community, and societal factors. The study will also examine the context of SB and strategies that participants have used and could or would consider using to break up the time they spend sitting. conditions: Cardiovascular Diseases conditions: Type 2 Diabetes studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Explanatory sequential mixed methods study of N=30 Black adults aged 55 and older with T2D. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 30 type: ESTIMATED name: strategies to break up SB measure: sedentary time sex: ALL minimumAge: 55 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Minnesota city: Minneapolis state: Minnesota zip: 55414 country: United States name: Mary O Whipple, PhD, RN, PHN role: CONTACT phone: 612-625-4470 email: whipp042@umn.edu lat: 44.97997 lon: -93.26384 hasResults: False
nctId: NCT06283836 id: Dexrem ATI 4-6 briefTitle: Dexmedetomidine vs. Remifentanil Conscious Sedation for Stapedotomy/Stapedectomy overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-03-15 date: 2024-02-28 date: 2024-02-28 name: Iuliu Hatieganu University of Medicine and Pharmacy class: OTHER briefSummary: Dexmedetomidine continuous intravenous infusion vs. remifentanil target-controlled infusion conscious sedation for stapedotomy/stapedectomy- a prospective, single-center, double-masked randomized trial
Participants will be randomly assigned to receive either dexmedetomidine or remifentanil, and the patient, the surgeon, and the investigator will not be aware of the treatment administered. conditions: Otosclerosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Dexmedetomidine name: Remifentanil measure: Patient satisfaction measure: Surgeon satisfaction measure: mean arterial pressure measure: Heart Rate measure: the need for adjuncts during intervention sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cluj County Clinical Emergency Hospital city: Cluj Napoca state: Cluj zip: 400006 country: Romania name: Caius Mihai Breazu, MD, PhD role: CONTACT phone: +40743010012 email: csbreazu@yahoo.com name: ioan florin marchis, MD, PhD role: CONTACT phone: +40757065205 email: mosku17@yahoo.com lat: 46.76667 lon: 23.6 hasResults: False
nctId: NCT06283823 id: 41821 briefTitle: Morphological Changes of Removable Orthodontic Retainers During the Use overallStatus: RECRUITING date: 2021-12-21 date: 2024-04-01 date: 2024-12-21 date: 2024-02-28 date: 2024-03-01 name: University of L'Aquila class: OTHER briefSummary: The retention is one of the stages of orthodontic treatment that aims to keep the teeth in the correct positions after orthodontic treatment. Without a retention phase, there is a tendency for the teeth to return to their initial position (relapse). To prevent relapse, at the end of orthodontic therapy the use of retaining devices to keep the teeth in their ideal position is required. The aim of the study is to analyse whether intraoral aging of removable retention devices can lead to morphological or dimensional changes, and whether or not these changes are related to orthodontic relapse, expressed as a change in the Peer Assessment Rating (PAR) index. The PAR index is an index that allows us to evaluate the relapse after orthodontic treatment. In this study the PAR index will be measured at the start of the retention period (T0), at the three-months follow-up (T1) and at the six months follow-up (T2). In particular, two types of thermoformed retainers with different cutouts will be evaluated to determine whether the presence of higher margins in a type of retainers allows to maintain greater stability over time and, therefore, to confer a mechanical and clinical advantage. conditions: Orthodontic Retainer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 36 type: ESTIMATED name: Thermoformed orthodontic retainer measure: Peer Assessment Rating (PAR) index measure: Volumetric superimposition of digital models measure: Thickness sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: University of L'Aquila status: RECRUITING city: L'Aquila zip: 67100 country: Italy name: Michele Tepedino, DDS role: CONTACT phone: +39 340 276 1456 email: michele.tepedino@univaq.it lat: 42.35055 lon: 13.39954 hasResults: False
nctId: NCT06283810 id: 2023/168 briefTitle: The Effects of Interpersonal Relationship Psychotherapy and Laughter Therapy overallStatus: RECRUITING date: 2024-02-01 date: 2024-06-30 date: 2024-09-30 date: 2024-02-28 date: 2024-03-06 name: Istanbul University - Cerrahpasa (IUC) class: OTHER briefSummary: Midwives, who have an important place in the health system, are expected to be equipped to meet the health care needs of women (Fışkın \& Doğan, 2020). Therefore, midwifery students, who are known to play a role in promoting women's health, should have good interpersonal relationships, good problem-solving skills, and high self-reflection and insight, which are assumed to be effective in both, in order to fulfill these responsibilities.
Translated with DeepL.com (free version) conditions: Midwifery Students studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE whoMasked: PARTICIPANT count: 40 type: ESTIMATED name: psychotherapy of interpersonal relationships name: laughter therapy name: Plasebo measure: self-reflection skills measure: problem solving skills measure: interpersonal relationship skills sex: FEMALE minimumAge: 18 Years maximumAge: 25 Years stdAges: ADULT facility: Istanbul University-Cerrahpasa status: RECRUITING city: Istanbul zip: 34320 country: Turkey name: Betül Uncu role: CONTACT phone: +095078421227 email: betul.uncu@iuc.edu.tr name: Nurten Kaya role: SUB_INVESTIGATOR name: Betül Uncu role: PRINCIPAL_INVESTIGATOR lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06283797 id: RECHMPL22_0346 id: 2023-A01661-44 type: OTHER domain: ANSM briefTitle: Efficacy of Automated Insulin Therapy Early Initiated After Diagnosis on Blood Glucose Control in Children and Adolescents With Type 1 Diabetes acronym: APATDIAGNOSIS overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-05 date: 2027-05 date: 2024-02-28 date: 2024-02-28 name: University Hospital, Montpellier class: OTHER name: Hopital Universitaire Robert-Debre name: University Hospital, Tours name: University Hospital, Angers name: University of Virginia briefSummary: The main objective is to assess whether hybrid closed-loop (HCL) insulin delivery initiated early after diagnosis of Type 1 diabetes (T1D) allows a better efficacy on glucose control than conventional standard insulin therapy with multiple daily insulin injections (MDI) or insulin pumps after one year of use.
The secondary objectives are to assess whether HCL initiated early after diagnosis of T1D allows: (1) Higher time spent with glucose level in the near-normal range, (2) Lower time spent in hypoglycemia and hyperglycemia, (3) Lower glucose variability, (4) Lower perceived burden of diabetes management, (5) Better preserved endogenous insulin secretion, all the above after one year of use, (6) Lower occurrence of interventions for hypoglycemia, versus conventional standard insulin therapy with MDI or insulin pump.
nctId: NCT06283784 id: YOVIS Capsules briefTitle: Study To Evaluate The Efficacy of a Proprietary Mix of Live Probiotics In The Prophylaxis Of Diarrhea In Adult Patients overallStatus: COMPLETED date: 2021-09-05 date: 2021-11-02 date: 2022-05-18 date: 2024-02-28 date: 2024-03-18 name: Biofarma class: INDUSTRY name: Hippocrates Research briefSummary: This is a double blind, randomized, placebo-controlled study. One-hundred subjects are randomized to receive either YOVIS or placebo over a period of 10 days.
The purpose is to determinate the efficacy of the treatment in subjects treated with antibiotic therapy, by measuring occurrence of Antibiotic Associated Diarrhoea (AAD) from baseline to the end of the observation period (28±2 days) conditions: Diarrhea studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a double blind, randomized, placebo-controlled study. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: YOVIS, the Investigational Food Supplement (IFS), is an oral formulation (capsules) containing definite mix of live probiotics. Placebo is an oral formulation of inert capsules. Placebo and YOVIS are identical in shape, size, colour and taste. Product test and placebo capsules will be indistinguishable.
Investigational food supplement products will be packed in an individual way for each subject included in the investigation. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 100 type: ACTUAL name: Yovis Capsules name: Placebo measure: Efficacy of YOVIS in preventing the incidence of AADD in subjects under antibiotic therapy measure: Severity and duration of AAD measure: Severity and duration of AAD measure: Evaluation of duration and severity of gastrointestinal symptoms measure: Evaluation of duration and severity of gastrointestinal symptoms measure: Evaluation of duration and severity of gastrointestinal symptoms measure: Impact of bowel habits on QoL measure: Effects of YOVIS, versus placebo, at each visit on the overall health status measure: Assessment of acceptability, safety and satisfaction grade of YOVIS versus placebo measure: Global Patient's self-reported acceptance at the end of study measure: Global acceptability (investigator) at the end of study sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: General Practitioner Ambulatory city: Sanremo state: Italy/Imperia zip: 18038 country: Italy lat: 43.81725 lon: 7.7772 hasResults: False
nctId: NCT06283745 id: 73225 briefTitle: Randomized Clinical Trial of Intranasal Injection of Platelet-Rich Plasma for Treatment of Parosmia overallStatus: NOT_YET_RECRUITING date: 2024-03-23 date: 2027-03-22 date: 2027-03-22 date: 2024-02-28 date: 2024-02-28 name: Stanford University class: OTHER briefSummary: This randomized clinical trial will evaluate the benefit of platelet-rich plasma (PRP) in the treatment of qualitative olfactory dysfunction (parosmia). PRP can be isolated from a patient's own blood and has been found in previous studies to have anti-inflammatory and pro-regenerative properties. It has been used across multiple specialties, such as Orthopedics, Facial Plastics, Dermatology, Neurology in injected form to treat a wide variety of tissues to encourage the body's inherent regenerative capacity. The investigators have completed a randomized controlled trial here, ending in 2022, evaluating it's use in post-SARS-CoV-2 olfactory loss which demonstrated safety and efficacy. Therefore, the investigators aim to assess the ability of PRP to improve olfactory function in patients with parosmia. conditions: Paraosmia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: PRP injections will be given to one arm while sham saline injections will be given to the other arm. primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 40 type: ESTIMATED name: Platelet-rich Plasma (PRP) name: Saline measure: Change in Sniffin Sticks Parosmia Test (SSParoT) measure: Change in questionnaire of olfactory disorders (QOD) scale score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Stanford Sinus Center / Stanford University School of Medicine city: Palo Alto state: California zip: 94304 country: United States name: Homer Abaya, BS role: CONTACT phone: 650-725-6500 email: habaya@stanford.edu name: Maxime Fieux, MD, PhD role: CONTACT phone: +33621611643 email: fieuxma@stanford.edu name: Zara Patel, MD role: PRINCIPAL_INVESTIGATOR lat: 37.44188 lon: -122.14302 hasResults: False
nctId: NCT06283732 id: 20392 briefTitle: A Clinical Study to Assess the Effect of a Supplement on Digestive Health, Overall Well-being, and Participant Experience. overallStatus: COMPLETED date: 2023-11-15 date: 2024-02-15 date: 2024-02-15 date: 2024-02-28 date: 2024-03-05 name: Amway Corp class: INDUSTRY name: Citruslabs briefSummary: The study aims to evaluate the effectiveness of a dietary supplement (greens powder), on improving digestive health, quality of life, energy levels, and satiety over a 14-day period. Participants, aged 18-65 and experiencing mild digestive issues, will consume the greens powder daily and report outcomes through diaries and questionnaires. conditions: Digestive System Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 70 type: ACTUAL name: Greens powder measure: Digestive Health Improvement measure: Quality of Life and Well-being Enhancement sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Citruslabs city: Santa Monica state: California zip: 90404 country: United States lat: 34.01945 lon: -118.49119 hasResults: False
nctId: NCT06283719 id: ZG006-002 briefTitle: Dose Escalation Study of ZG006 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma, Followed by Dose Expansion Study in Participants With Advanced Small Cell Lung Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2026-04 date: 2024-02-28 date: 2024-02-28 name: Suzhou Zelgen Biopharmaceuticals Co.,Ltd class: INDUSTRY briefSummary: This is a multicenter, open-label phase I/II study, divided into 2 parts:
Part 2 is a phase II dose-expansion study of ZG006, aiming to investigate the efficacy and safety of ZG006 in patients with advanced small cell lung cancer. conditions: Small Cell Lung Cancer conditions: Neuroendocrine Cancer studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 105 type: ESTIMATED name: ZG006 measure: Objective response rate (ORR) measure: Number of participants with adverse events (AEs) measure: Number of participants with serious adverse events (SAEs) measure: Duration of response (DOR) measure: Disease control rate (DCR) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai Chest Hospital city: Shanghai state: Shanghai country: China name: Shun Lu role: CONTACT name: Shun Lu, MD role: PRINCIPAL_INVESTIGATOR lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06283706 id: 1000081113 briefTitle: The Tryptophan Requirement in Healthy Adults overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-07-01 date: 2025-12-01 date: 2024-02-28 date: 2024-03-01 name: The Hospital for Sick Children class: OTHER name: Canadian Institutes of Health Research (CIHR) briefSummary: The aging population is growing rapidly. For the first time ever, Canadian seniors outnumbered young adults in 2016. Aging is associated with many physical and metabolic deteriorations including the loss of muscle mass and strength, insulin resistance, increased inflammation and oxidative stress.
The muscles of our bodies are composed of proteins and proteins are made of small building blocks called amino acids. Our bodies have the ability to make some amino acids which are called the non-essential amino acids. However, there are certain amino acids that our body's need to make protein but can only be supplied from the foods that we consume. These are called essential amino acids. Tryptophan is one of the essential amino acids that the body needs. Tryptophan is required for protein synthesis and acts as a precursor for serotonin and nicotinic acid. Therefore, there may be a need for more threonine in the diet of older adults. However, the current requirement for threonine is based on studies conducted exclusively in young adults. Thus, the purpose of this study is to find out how much tryptophan older adults need. conditions: Healthy Aging studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 40 type: ESTIMATED name: Tryptophan measure: Determination of tryptophan requirement in adults >60 years of age. sex: ALL minimumAge: 60 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06283693 id: RojdaBAYARYILDIRIM briefTitle: The Effect of Mindfulness-based Stress Reduction Programme Given to Infertile Women overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2025-05-10 date: 2025-06-10 date: 2024-02-28 date: 2024-02-28 name: Saglik Bilimleri Universitesi class: OTHER briefSummary: Purpose of the Study This study aims to determine the effect of mindfulness-based stress reduction program given to infertile women on perceived stress, anxiety, depression and salivary cortisol.
Materials and Method It will be conducted in a randomized controlled experimental design. This randomized controlled trial will follow the Consolidated Standards of Reporting Trials (CONSORT) 2010 guidelines. conditions: Dependent Variables of the Study: Anxiety, Depression, Stress and Salivary Cortisol Levels conditions: Independent Variables of the Study: Women's Socio-demographic Characteristics, Mindfulness-based Stress Reduction Program studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized controlled classical experimental study primaryPurpose: OTHER masking: SINGLE maskingDescription: Computer-assisted randomization will be used in the study, and participants will be randomized to an intervention or control list control group in a 1:1 ratio by entering the number of samples to be reached through the program whose URL address is https://www.randomizer.org. Women who apply to the infertility outpatient clinic by the researcher and volunteer for the study who meet the sample selection criteria will be given numbers according to the order of outpatient clinic registration. A randomization sequence will be created according to these numbers and women will be assigned to the intervention and control groups by computer-assisted randomization. Since the study is a thesis, blinding will not be possible due to its nature. whoMasked: PARTICIPANT count: 86 type: ESTIMATED name: mindfulness-based stress reduction measure: Informed Voluntary Consent Form (Annex 1) measure: Identifying Characteristics Information Form (Annex 2) measure: Perceived Stress Scale (Appendix 3): measure: Depression-Anxiety-Stress Scale (Appendix 4) measure: Collection and study of salivary cortisol samples measure: Perceived Stress Scale (Appendix 3): measure: Depression-Anxiety-Stress Scale (Appendix 4) measure: Collection and study of salivary cortisol samples measure: Perceived Stress Scale (Appendix 3): measure: Depression-Anxiety-Stress Scale (Appendix 4) measure: Collection and study of salivary cortisol samples sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Saglık Bilimleri Universitesi city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06283680 id: 2024 briefTitle: The Effect of Nutrition and BMI on on Lung Capacity, Functional Capacity and Mortality in End-Stage Lung Patients overallStatus: ACTIVE_NOT_RECRUITING date: 2023-02-28 date: 2024-04-28 date: 2024-05-31 date: 2024-02-28 date: 2024-04-08 name: Aylin Seylam Küşümler class: OTHER name: Koşuyolu Yüksek İhtisas Training and Research Hospital briefSummary: The aim of this study was to investigate the effect of nutritional risk index, BMI and body fat, muscle ratio on functional capacity, lung capacity, exercise capacity index, all-cause mortality, post-transplant intensive care unit stay and survival time in end-stage lung patients on the lung transplant list. conditions: Lung Transplant studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 213 type: ESTIMATED name: Lung transplantation measure: BMI measure: Nutrition risk index sex: ALL minimumAge: 19 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: OkanU city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False