Maximum tolerated dose (MTD) Response rates Participants will be treated with the investigational medicinal product and will be followed for 36 months. conditions: Refractory B-Cell Lymphoma conditions: B-cell Lymphoma Recurrent studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Phase I/II, pilot, open, national, prospective, multicentre, non-randomised primaryPurpose: TREATMENT masking: NONE count: 27 type: ESTIMATED name: CAR-T cells therapy measure: Maximum tolerated dose (MTD) measure: Efficiency measure: Procedure-related mortality (PRM) measure: Toxicity assessment measure: Response (overall and complete) measure: Duration of response measure: Progression-free survival (PFS) measure: Overall survival (OS) measure: Perceived general well-being measure: Molecular and cell biology exploratory objectives: Response dynamics measure: Molecular and cell biology exploratory objectives: Response dynamics measure: Molecular and cell biology exploratory objectives: Response dynamics measure: Molecular and cell biology exploratory objectives: In vivo survival of TranspoCART19 cells in peripheral blood measure: Molecular and cell biology exploratory objectives: Analysis of molecular markers which are possibly related to the tumor response to TranspoCART19 cells measure: Molecular and cell biology exploratory objectives: Evaluation of serum biomarkers of toxicity induced by TranspoCART19 cells (cytokine release syndrome and neurotoxicity) measure: Molecular and cell biology exploratory objectives: Epigenetic studies on mononuclear bone marrow cells. sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Institut Català d'Oncologia Hospital status: NOT_YET_RECRUITING city: Hospitalet de Llobregat state: Barcelona country: Spain name: Esperanza López-Franco, PhD role: CONTACT phone: 923291200 phoneExt: 55779 email: uicec.coordinacion@ibsal.es name: Alberto Musetti role: CONTACT lat: 41.35967 lon: 2.10028 facility: Virgen de la Arrixaca University Hospital status: NOT_YET_RECRUITING city: El Palmar state: Mur country: Spain name: Esperanza López-Franco, PhD role: CONTACT phone: 923291200 phoneExt: 55779 email: uicec.coordinacion@ibsal.es name: Joaquín Gómez-Espuch role: CONTACT lat: 37.93939 lon: -1.16095 facility: Clínica Universidad de Navarra status: RECRUITING city: Pamplona state: Navarra zip: 31008 country: Spain name: Esperanza López-Franco, PhD role: CONTACT phone: 923291200 phoneExt: 55779 email: uicec.coordinacion@ibsal.es name: Carlos Grande role: CONTACT lat: 42.81687 lon: -1.64323 facility: University Hospital of Navarra status: NOT_YET_RECRUITING city: Pamplona state: Navarra country: Spain name: Esperanza López-Franco role: CONTACT phone: 923291200 phoneExt: 55779 email: uicec.coordinacion@ibsal.es name: María Carmen Mateos-Rodríguez role: CONTACT lat: 42.81687 lon: -1.64323 facility: Hospital Clínic status: NOT_YET_RECRUITING city: Barcelona country: Spain name: Esperanza López-Franco, PhD role: CONTACT phone: 923291200 phoneExt: 55779 email: uicec.coordinacion@ibsal.es name: Valentín Ortiz-Maldonado role: CONTACT lat: 41.38879 lon: 2.15899 facility: Fundación Jiménez Díaz Hospital status: NOT_YET_RECRUITING city: Madrid country: Spain name: Esperanza López-Franco role: CONTACT phone: 923291200 phoneExt: 55779 email: uicec.coordinacion@ibsal.es name: Javier Cornago-Navascués role: CONTACT lat: 40.4165 lon: -3.70256 facility: Salamanca University Health Care Complex status: RECRUITING city: Salamanca zip: 37007 country: Spain name: Esperanza López-Franco, PhD role: CONTACT phone: 923291200 phoneExt: 55779 email: uicec.coordinacion@ibsal.es name: Lucía López-Corral, PhD role: CONTACT lat: 40.96882 lon: -5.66388 facility: Virgen del Rocio Hospital status: NOT_YET_RECRUITING city: Sevilla country: Spain name: Esperanza López-Franco, PhD role: CONTACT phone: 923291200 phoneExt: 55779 email: uicec.coordinacion@ibsal.es name: José Antonio Pérez-Simón role: CONTACT lat: 37.38283 lon: -5.97317 hasResults: False