4. Urine and serum samples were collected before and after treatment; conditions: Diabete Mellitus conditions: Aging conditions: Metabolic Disorders conditions: Traditional Chinese Medicine conditions: Randomized Controlled Trial studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 240 type: ESTIMATED name: Buyuan Zhixiao Formula name: Placebo measure: HbA1c measure: Fasting blood glucose measure: 2-hour postprandial blood glucose measure: blood pressure measure: weight measure: waist circumference measure: BMI measure: Total Cholesterol measure: Triglycerides measure: High density lipoprotein cholesterol measure: Low density lipoprotein cholesterol measure: Ankle-Brachial Index（ABI） measure: Fasting insulin measure: C-peptide measure: insulin resistance index measure: islet β-cell function index measure: lipid Lipid accumulation product measure: visceral adiposity index measure: Measurement Results of Tumor Necrosis Factor-alpha Levels at Different Time Points measure: Concentration Variation of Interleukin-10 measure: Change in Homocysteine Levels measure: Average Concentration of Interleukin-6 measure: Change in Endothelin-1 Levels measure: Average Concentration of Nitric Oxide measure: Concentration Variation of Von Willebrand Factor measure: Measurement Results of Vascular Endothelial Growth Factor Levels at Different Time Points measure: Change in Matrix Metalloproteinase-9 Levels" or "Participants' Matrix Metalloproteinase-9 Concentration measure: Average Concentration of Soluble Intercellular Adhesion Molecule-1 measure: Change in Serum Tau Protein Levels measure: Average Concentration of Aβ40 measure: Average Concentration of Aβ42 measure: Change in Neurofilament Light Chain Protein Levels measure: Carotid Ultrasound; Carotid Intima-Media Thickness. measure: Activities of Daily Living Scale score; Fried Frailty Phenotype Scale; Mini Nutritional Rating Scale; MoCA scale score; Traditional Chinese Medicine Kidney Deficiency and Blood Stasis Syndrome Scale score. measure: Montreal Cognitive Assessment Score measure: Fried Frailty Phenotype Scale measure: Activities of Daily Living Scale score measure: Mini Nutritional Rating Scale measure: Serum and urine metabolomics sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: China Academy of Chinese Medical Sciences Guang'anmen Hospital city: Beijin state: Beijing zip: 100053 country: China name: Qing Ni, postgraduate role: CONTACT phone: 010-88001245 email: 1831479145@qq.com name: zhige Wen, postgraduate role: CONTACT phone: 15890643963 email: 1831479145@qq.com facility: Cangzhou integrative medicine hospital city: Hebei country: China name: zhongyong zhang, postgraduate role: CONTACT phone: 18031783396 email: zzyhappy666@126.com facility: Hohhot Mongolian Traditional Chinese Medicine Hospital city: Neimeng country: China facility: Binzhou Traditional Chinese Medicine Hospital city: Shandong country: China name: lijuan Du, postgraduate role: CONTACT phone: 18800102622 email: 137425497@qq.com facility: Yantai Baishi Traditional Chinese Medicine Hospital city: Shandong country: China facility: The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine city: Tianjin country: China name: bin Wang, postgraduate role: CONTACT phone: 13051395068 lat: 39.14222 lon: 117.17667 hasResults: False