hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06344858 id: 124/2021 briefTitle: Characterization of the Temporal Profile of the Anti-nociceptive Effect of Ketamine Bolus Measured With ANI acronym: Keta-ANI overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2024-08-31 date: 2024-12-31 date: 2024-04-03 date: 2024-04-03 name: Pontificia Universidad Catolica de Chile class: OTHER briefSummary: Ketamine, an intravenous anesthetic, and analgesic agent has experienced a resurgence in its clinical application, particularly in subanesthetic doses. The aim of this observational study is to characterize the changes in the Nociception Analgesia Index (ANI) associated with the administration of an intravenous ketamine bolus using a Pharmacokinetic-Pharmacodynamic (PKPD) modeling approach. The pharmacokinetic parameters of the Domino model will be used to predict ketamine plasma concentrations after the bolus dose. An Emax model and a link model assuming a first order rate constant (ke0) will be used to fit the data. Modeling analysis will use the program NONMEM. It is expected to recruit a total of 20 patients between 40 and 80 years, ASA I, II or III, programmed for elective surgery with general anesthesia. ANI values will be recorded every 6 seconds for 5 minutes from the bolus dose. conditions: Analgesia conditions: Ketamine conditions: Pharmacokinetic studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED name: Ketamine measure: To measure ANI values after ketamine bolus dose administration. measure: To determine the time maximum predicted concentrations in each patient measure: To determine the time to maximum effect of a bolus dose of ketamine measure: To predict ketamine plasma concentrations values after ketamine bolus measure: To calculate the difference between the time of maximum ANI effect measure: Patient weight sex: ALL minimumAge: 40 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pontificia Universidad Catolica de Chile city: Santiago state: Metropolitana zip: 450881 country: Chile lat: -33.45694 lon: -70.64827 hasResults: False
nctId: NCT06344845 id: PUMCH-NM-PBB3 briefTitle: Clinical Study of [18F] PM-PBB3 PET Imaging of Tau Protein in Neurodegenerative Diseases overallStatus: RECRUITING date: 2022-11-01 date: 2024-11 date: 2025-11 date: 2024-04-03 date: 2024-04-03 name: Peking Union Medical College Hospital class: OTHER briefSummary: In terms of the diagnostic technology of brain neurodegenerative diseases, the injection of positron tracers into the human body, so that it can combine with the corresponding protein, and show its distribution through PET imaging is a mature technology in the industry. At present, several research groups around the world are working on the development and clinical efficacy evaluation of their respective tau imaging agent compounds.This clinical research project intends to display the abnormal changes of tau protein in living brain through \[18F\]PM-PBB3 PET imaging, which is a second-generation tracer further optimized on the basis of \[11C\]PBB3, and has the advantages of closer binding to tau protein entanglement and less non-specific binding than similar imaging agents. Better image quality and a wider range of clinical applications. conditions: Neurodegenerative Diseases studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 80 type: ESTIMATED name: 18F-PBB3 PET/CT scan measure: Diagnostic Performance measure: Clinical Stage sex: ALL minimumAge: 49 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking Union Medical College Hospital status: RECRUITING city: Beijing state: Beijing zip: 100730 country: China name: Chenhao Jia, M.D. role: CONTACT phone: 18548703382 email: jiachenhao24@163.com name: Ruixue Cui, M.D. role: PRINCIPAL_INVESTIGATOR lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06344832 id: K5098 briefTitle: SSTR PET/CT for Preoperative N Stage Evaluation in GEP-NETs overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2028-03-01 date: 2030-03-01 date: 2024-04-03 date: 2024-04-03 name: Peking Union Medical College Hospital class: OTHER briefSummary: The research aims to prospectively include patients with GEP-NENs, undergo preoperative imaging assessment (including PET/CT and contrast-enhanced CT), and accurately delineate lymph node regions. Through postoperative pathological reports, the diagnostic performance of lymph node metastasis (LNM) in GEP-NENs is evaluated. Factors influencing the diagnostic accuracy of SSTR-PET/CT and contrast-enhanced CT are also investigated. conditions: Gastro-entero-pancreatic Neuroendocrine Tumor studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 40 type: ESTIMATED measure: lymph node metastasis status sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06344819 id: 24-062 briefTitle: An Acupuncture Study for People At High Risk for Sepsis overallStatus: RECRUITING date: 2024-03-20 date: 2028-03-20 date: 2028-03-20 date: 2024-04-03 date: 2024-04-03 name: Memorial Sloan Kettering Cancer Center class: OTHER briefSummary: Researchers think acupuncture may improve outcomes for participants with sepsis, based on laboratory studies and previous studies in people with sepsis. The purpose of this study to see whether real acupuncture can improve outcomes for participants with sepsis when compared to sham acupuncture. Sham acupuncture is performed the same way as real acupuncture but will use different needles and target different sites or places on the body than real acupuncture. conditions: Sepsis studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 78 type: ESTIMATED name: Acupuncture name: Sham Acupuncture measure: Number of participants recruited compared to the number of participants who complete study treatment. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Memorial Sloan Kettering Cancer Center status: RECRUITING city: New York state: New York zip: 10065 country: United States name: Gary Deng, MD, PhD role: CONTACT phone: 646-608-8556 lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06344806 id: oyunlastirmabeslenme briefTitle: The Effect of Gamification on Breastfeeding Self-Efficacy and Infant Nutrition Attitudes of Pregnant Women acronym: gamification overallStatus: COMPLETED date: 2023-02-01 date: 2023-03-30 date: 2023-05-30 date: 2024-04-03 date: 2024-04-03 name: Lokman Hekim Üniversitesi class: OTHER_GOV briefSummary: Objective: This study was conducted to determine the effect of breastfeeding education given through gamification on breastfeeding self-efficacy and infant feeding attitudes of pregnant women.
Method: This study is a randomized controlled pretest-posttest parallel group experimental study, and 28 women included in the experimental group and 28 women in the control group. In the study, "Sociodemographic Information Form", "Breastfeeding Self-Efficacy Scale Short Form-Antenatal Form (BSES-SF), ", "Infant Nutrition Attitude Scale (IOWA)" Form was used. The data analyzed in SPSS program.
Conclusion and Suggestions: In this planned study, it was aimed to teach women about breastfeeding in a digital environment in a fun way. In this study, it is found that breastfeeding education given through gamification have a positive effect on breastfeeding self-efficacy and infant feeding attitudes of pregnant women. conditions: Breastfeeding studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 60 type: ACTUAL name: Gamified Breastfeeding Education measure: breastfeeding self-efficacy measure: infant feeding attitudes sex: FEMALE minimumAge: 18 Years maximumAge: 49 Years stdAges: ADULT facility: Lokman Hekim University city: Ankara country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06344793 id: YOUNGBC-30 briefTitle: Initial CDK 4/6 Inhibitor Plus Endocrine Therapy Versus Initial Chemotherapy in HR Positive, HER2 Negative Unresectable or Metastatic Breast Cancer overallStatus: RECRUITING date: 2023-05-20 date: 2024-10-01 date: 2024-11-01 date: 2024-04-03 date: 2024-04-03 name: Fudan University class: OTHER briefSummary: A multi-center, real world study to evaluate the clinical outcomes between initial CDK 4/6 Inhibitor plus endocrine therapy and initial chemotherapy in HR positive, HER2 negative unresectable or metastatic breast cancer. conditions: Breast Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 200 type: ESTIMATED measure: PFS measure: OS sex: FEMALE minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fudan University Shanghai Cancer Center status: RECRUITING city: Shanghai state: Shanghai zip: 200032 country: China name: Biyun Wang role: CONTACT phone: 18017312387 email: pro_wangbiyun@163.com lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06344780 id: YOUNGBC-28 briefTitle: Abemaciclib, Palbociclib or Dalpiciclib Combined With Endocrine Therapy as First-line Treatment in HR Positive, HER2 Negative Unresectable or Metastatic Breast Cancer overallStatus: RECRUITING date: 2023-05-20 date: 2024-10-01 date: 2024-11-01 date: 2024-04-03 date: 2024-04-03 name: Fudan University class: OTHER briefSummary: A multi-center, real world study to evaluate the clinical outcomes and safety of Abemaciclib, Palbociclib or Dalpiciclib combined with endocrine therapy as first-line treatment in HR Positive, HER2 Negative unresectable or metastatic Breast Cancer. conditions: Breast Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 150 type: ESTIMATED measure: PFS measure: OS sex: FEMALE minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fudan University Shanghai Cancer Center status: RECRUITING city: Shanghai state: Shanghai zip: 200032 country: China name: Biyun Wang role: CONTACT phone: 18017312387 email: pro_wangbiyun@163.com lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06344767 id: YOUNGBC-27 briefTitle: Positive ER Expression Assessed by 18F-FES PET/CT in the MBC With ER-negative Primary Tumor overallStatus: ACTIVE_NOT_RECRUITING date: 2023-09-01 date: 2024-05-05 date: 2024-05-05 date: 2024-04-03 date: 2024-04-03 name: Fudan University class: OTHER briefSummary: To investigate the treatment pattern and efficacy of patients with negative primary ER lesion but positive ER expression in MBC using a novel convenient way of 18F-fluoroestradiol positron emission tomography/computed tomography (18F-FES PET/CT). conditions: Breast Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 19 type: ACTUAL measure: Progression free survival (PFS) measure: Adverse events sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: China,Shanghai city: Shanghai state: Shanghai zip: 200032 country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06344754 id: gamifiedfamilyplanning briefTitle: Gamification in Family Planning Education: Impact on University Students overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-15 date: 2024-02-15 date: 2024-04-15 date: 2024-04-03 date: 2024-04-03 name: Lokman Hekim Üniversitesi class: OTHER_GOV briefSummary: More than 3 billion of the worlds population are young people under the age of 25. According to WHO data, one million girls under the age of 15 give birth each year, mostly in low- and middle-income countries, and 3 million adolescent girls between the ages of 15 and 19 are exposed to unsafe abortions. Failure to meet the family planning needs of young people in a timely, adequate and appropriate manner can have significant public health impacts. According to World Health Statistics, the global birth rate for girls between 15 and 19 years of age is 49 out of 1000, and early pregnancy and childbirth can lead to serious health and social problems. In addition, this age group does not have sufficient information about pregnancy and its complications, and their access to and utilization of health services is low. Inadequacies in the education of adolescents on sexual issues and sociocultural differences further increase the sexual and reproductive health risks of young people in the university period. Information and services that will enable individuals to understand their sexuality and help them protect themselves from sexual risks should be provided specifically for that age. Therefore, it is important for young people to know family planning methods. In this study, it was aimed to examine the effect of family planning education to be given with gamification method, which is different from the classical method in the literature, on the knowledge and attitudes of university students. conditions: Gamification conditions: Reproductive Health conditions: Family Planning conditions: Students studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: pre-test and post-test interventional study primaryPurpose: SUPPORTIVE_CARE masking: NONE maskingDescription: the person doing the statistical analysis will be blinded count: 40 type: ESTIMATED name: Gamified education measure: Knowledge and attitude towards family planning sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Lokman Hekim University city: Ankara zip: 06300 country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06344741 id: sdilek6 briefTitle: Consequences of Admission to the Delivery Room in the Early and Late Phases overallStatus: RECRUITING date: 2023-11-13 date: 2024-04-30 date: 2024-05-31 date: 2024-04-03 date: 2024-04-03 name: Kocaeli University class: OTHER briefSummary: This study will be conducted to compare maternal and neonatal outcomes of pregnant women who applied to the delivery room in the early (latent) and late (active) phase. The population of the research will consist of participants who applied to Darıca Farabi Training and Research Hospital for birth. To determine the sample size of the study, first, those who meet the inclusion criteria and are admitted to the delivery room in the latent phase and those who are accepted in the active phase will be numbered and recruited sequentially. When the number of participants in the 100 latent and 100 active acceptance groups is reached, the effect size will be calculated using the STAI score averages and the G\*Power program, and the exact sample number will be determined, taking into account possible data losses. If necessary, data collection will continue until the target number is reached. Randomization will not be applied in the study. Data will be collected with the maternal and neonatal information form, State and Trait Anxiety Scale (STAI), Fear of Birth Scale, Neonatal Pain and Stress Assessment Scale (ALPS-Neo) and Visual analog scale for birth satisfaction. Data will be collected by the assistant researcher. Statistical analysis will be performed using IBM SPSS Statistic. Descriptive statistical methods will be used to evaluate socio-demographic data, and parametric/nonparametric tests will be used for comparative analyses. conditions: Fear of Childbirth conditions: Neonatal conditions: Pain conditions: Maternal Distress (During Labor) conditions: Satisfaction studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 200 type: ESTIMATED name: Accepted in latent phase name: Accepted in active phase measure: Neonatal pain and stress measure: Birth satisfaction measure: Maternal Anxiety measure: Fear of Birth sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Kocaeli University status: RECRUITING city: Kocaeli zip: 41380 country: Turkey name: Sena Dilek Aksoy, Ph.D. role: CONTACT phone: +902623034739 email: sena.dilek@kocaeli.edu.tr name: Cemile Gokce role: SUB_INVESTIGATOR lat: 39.62497 lon: 27.51145 hasResults: False
nctId: NCT06344728 id: INS1007-110 briefTitle: A Study to Assess the Relative Bioavailability of Brensocatib Pediatric Oral Solution to Oral Tablets in Healthy Participants acronym: INS1007 overallStatus: RECRUITING date: 2024-04-30 date: 2024-05-21 date: 2024-05-21 date: 2024-04-03 date: 2024-04-09 name: Insmed Incorporated class: INDUSTRY briefSummary: The primary purpose of this study is to determine the relative bioavailability of brensocatib between the pediatric oral solution and oral tablets in healthy participants. conditions: Healthy Participants studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 24 type: ESTIMATED name: Brensocatib Oral Solution name: Brensocatib Oral Tablet measure: Relative Bioavailability Between Brensocatib Pediatric Oral Solution and Oral Tablets for Area Under the Concentration-time Curve from Time 0 Extrapolated to Infinity (AUC∞) of Brensocatib in Plasma measure: Number of Participants who Experienced at Least one Adverse Event (AE) measure: Concentration of Brensocatib in Plasma sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: USA001 status: RECRUITING city: Dallas state: Texas zip: 75230 country: United States lat: 32.78306 lon: -96.80667 hasResults: False
nctId: NCT06344715 id: SL-T10-001_P1 briefTitle: Phase 1 Study Evaluating Safety and Tolerability of SL-T10, GX-I7, and Pembrolizumab Triple Combination in mCRPC. overallStatus: RECRUITING date: 2022-10-17 date: 2024-10-31 date: 2024-10-31 date: 2024-04-03 date: 2024-04-03 name: SL VAXiGEN class: INDUSTRY briefSummary: The purpose of this study is to evaluate the efficacy and safety of SL-T10 and GX-I7 or SL-T10, GX-I7 and pembrolizumab in patients with metastatic castration-resistant prostate cancer (mCRPC). conditions: Metastatic Castration-resistant Prostate Cancer (mCRPC) studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 78 type: ESTIMATED name: SL-T10 name: GX-I7 name: Pembrolizumab measure: Number of participants with treatment-emergent adverse events (TEAEs) measure: Number of participants with Serious adverse events (SAEs) as assessed by CTCAE v5.0 measure: PSA response rate measure: PSA progression free survival measure: Radiographic progression free survival measure: Change of induced T-cell responses for SL-T10 vaccine sex: MALE minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Seoul National University Hospital status: RECRUITING city: Seoul country: Korea, Republic of lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06344702 id: 2024PHB065-001 briefTitle: The Effect of CPAP on Maternal and Infant Outcomes in Pregnant Women With OSAS overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-31 date: 2026-05-01 date: 2024-04-03 date: 2024-04-23 name: Peking University People's Hospital class: OTHER briefSummary: The goal of this clinical trial is to learn about the impact of CPAP on the maternal and infant outcomes of women with obstructive sleep apnea syndrome. The main questions aim to answer are:
The CPAP treatment group received standardized CPAP treatment and routine prenatal care, while the non CPAP treatment group and non OSAS group only received routine prenatal care. conditions: Maternal Hypertension studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 108 type: ESTIMATED name: CPAP measure: Explore the effects of CPAP on placental weight and birth weight/placental weight ratio in OSAS pregnant women. sex: FEMALE minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT hasResults: False
nctId: NCT06344689 id: SH9H-2023-T477 briefTitle: Surgical Correction of Cicatricial Ectropion overallStatus: COMPLETED date: 2023-12-12 date: 2024-02-28 date: 2024-03-27 date: 2024-04-03 date: 2024-04-03 name: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University class: OTHER briefSummary: The main purpose of this study is to verify and compare the treatment effects of scarred ectropion surgery, perform statistical descriptions, compare patients undergoing tarsal strip and skin flap procedures with those undergoing simple skin flap treatment, and compare their pre- and post-operative Ectropion Grading Scale (EGS) and subjective and objective symptom changes.
Secondary Objective: To observe the incidence and resolution of complications after lower eyelid ectropion surgery. Compare postoperative effects among patients of different ages undergoing the same surgery. conditions: Patients With Cicatricial Ectropion conditions: Over 18-year-old conditions: With Complete Clinical Record studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 26 type: ACTUAL name: Surgical treatment measure: Ectropion Grading Scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai ninth people's hospital city: Shanghai zip: 200011 country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06344676 id: FSIE2024Robot id: 6773 type: OTHER domain: CERec UAB briefTitle: Study of the Impact of a Social Robot on Unwanted Loneliness in Elderly People Living in Nursing Homes acronym: WITHPEPPER overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-07-30 date: 2024-09-30 date: 2024-04-03 date: 2024-04-03 name: Sara Domenech class: OTHER briefSummary: The goal of this clinical trial is to assess the usefulness of social robots reducing unwanted loneliness in persons over 65 living in nursing homes. The main questions it aims to answer are:
The persons in living units allocated to the control group will receive the same attentions and care which were receiving before the enrollment in the study, whereas the persons allocated to the intervention group will add a social robot to their usual therapies and activities. Namely participants will do three weekly individual cognitive stimulation sessions of 10 minutes each one, two weekly group mobility sessions of 30 minutes, one monthly conversational group about customs and traditions of 60 minutes, one 10 minutes videoconference per month with their relatives. Furthermore, participants will be able to interact freely with the robot to obtain information about the center (for instance, what is for dinner) and its activities.
The intervention will last 8 weeks. To assess the effectivity, the investigators will assess both groups, before the intervention, at the end of the intervention and 4 weeks after finishing the intervention. conditions: Elderly People conditions: Nursing Home Residents conditions: Loneliness conditions: Quality of Life conditions: Wellbeing conditions: Social Interaction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 162 type: ESTIMATED name: Cognitive name: Mobility name: Social name: Relational name: Usual Care measure: Loneliness measure: Well-being measure: Quality of life, irrespective of the disease measure: Satisfaction with life measure: Depressive symptoms measure: Social Support measure: Communication sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT hasResults: False