nctId: NCT06270615 id: CRCBDD1712 briefTitle: Prospective Validation of the SHOCKMATRIX Hemorrhage Predictive Model acronym: SHOCKMATRIX overallStatus: RECRUITING date: 2022-07-01 date: 2024-06 date: 2024-06 date: 2024-02-21 date: 2024-02-21 name: Assistance Publique - Hôpitaux de Paris class: OTHER name: Traumabase Group name: Capgemini Invent name: Ecole polytechnique name: EHESS (Ecole des hautes études en sciences sociales) name: CNRS (Centre national de la recherche scientifique) briefSummary: Management of post-traumatic severe hemorrhage remains a challenge to any trauma care system. Studying integrated and innovative tools designed to predict the risk of early severe hemorrhage (ESH) and resource needs could offer a promising option to improve clinical decisions and then shorten the time of intervention in the context of pre-hospital severe trauma. As evidence seems to be lacking to address this issue, this ambispective validation study proposes to assess on an independent cohort the predictive performance of a newly developed machine learning-based model, as well as the feasibility of its clinical deployment under real-time healthcare conditions. conditions: Wounds and Injuries conditions: Traumatic Shock conditions: Hemorrhagic Shock studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 1500 type: ESTIMATED name: Ambispective validation of machine learning-based predictive model measure: Fβ-score, with β = 4 measure: Common binary classification metrics sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beaujon Hospital AP-HP, Anesthesia-Intensive Care Department status: RECRUITING city: Clichy zip: 92110 country: France name: Mathilde Holleville, MD role: CONTACT email: mathilde.holleville@aphpr.fr lat: 48.90018 lon: 2.30952 facility: Grenoble Alpes University Hospital status: RECRUITING city: La Tronche zip: 38700 country: France name: Tobias Gauss, MD role: CONTACT phone: +33476769288 email: tgauss@chu-grenoble.fr name: Samia Salah role: CONTACT phone: +33476769288 email: SSalah1@chu-grenoble.fr lat: 45.20429 lon: 5.73645 facility: Bicêtre Hospital AP-HP, Anesthesia-Intensive Care Department status: RECRUITING city: Le Kremlin-Bicêtre zip: 94270 country: France name: Marie Werner, MD role: CONTACT email: marie.werner@aphp.fr lat: 48.81471 lon: 2.36073 facility: Lille University Hospital, Anaesthesia and Intensive Care Unit status: RECRUITING city: Lille zip: 59037 country: France name: Benjamin Bijok, MD role: CONTACT email: Benjamin.BIJOK@CHRU-LILLE.FR lat: 50.63297 lon: 3.05858 facility: Pitié-Salpêtrière Hospital AP-HP, Anesthesia-Intensive Care Department status: RECRUITING city: Paris zip: 75013 country: France name: Arthur James, MD role: CONTACT email: arthur.james@aphp.fr lat: 48.85341 lon: 2.3488 facility: Georges-Pompidou European Hospital AP-HP, Anesthesia-Intensive Care Department status: RECRUITING city: Paris zip: 75015 country: France name: Nathalie Delhaye, MD role: CONTACT email: nathalie.delhaye@aphp.fr lat: 48.85341 lon: 2.3488 facility: University Hospitals Strasbourg, Anaesthesia, Intensive Care and Peri-Operative Medicine Department status: RECRUITING city: Strasbourg zip: 67200 country: France name: Alain Meyer, MD role: CONTACT email: alain.meyer@chru-strasbourg.fr lat: 48.58392 lon: 7.74553 facility: University Hospital of Toulouse, Polyvalent Intensive Care status: RECRUITING city: Toulouse zip: 31059 country: France name: Véronique Ramonda, MD role: CONTACT email: ramonda.v@chu-toulouse.fr lat: 43.60426 lon: 1.44367 hasResults: False