114 men and women with a BMI of 23-40 kg/m2, aged 45-75 years will be included in the study. Participants will follow both an 8-week completely controlled diet in which all meats are of plant-based origin (PBMAs) and an 8-week diet in which all meats are of animal origin in randomized order with a 10-week wash-out period. Before the intervention starts, the participants will be characterized to describe them on anthropometrics, glucose tolerance and insulin sensitivity, genetics, sleep patterns, and stress levels. Before the start and at the end of each 8-week dietary intervention period, several measurements, including systolic blood pressure monitoring and secondary outcome measures will be done. Additionally, systolic and diastolic blood pressure will be monitored throughout the dietary interventions and a small quantity of parameters related to the secondary objectives will be measured. conditions: Blood Pressure conditions: Cardiometabolic Health studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Participants will follow both an 8-week completely controlled dietary intervention followed by a 10-week washout period followed by another 8-week completely controlled dietary intervention. primaryPurpose: PREVENTION masking: SINGLE maskingDescription: Treatment order (PBMA intervention - Meat intervention versus Meat intervention - PBMA intervention) is masked for the researchers. The order is not masked for participants. whoMasked: INVESTIGATOR count: 114 type: ESTIMATED name: Standardized diet with commercially available animal meats (comparator products) name: Standardized diet with commercially available PBMAs (intervention products) measure: Systolic blood pressure measure: Diastolic blood pressure measure: Home systolic blood pressure measure: Home diastolic blood pressure measure: Home heart rate measure: Fasting blood HbA1c levels measure: Fasting blood glucose levels measure: Fasting blood insulin levels measure: Fasting blood lipid spectrum measure: Fasting blood metabolite profile measure: Fasting blood proteomic profile measure: Fasting blood cell transcriptomic profile measure: Fasting blood nutritional status measure: Blood immune markers measure: Blood immune cell populations measure: Metabolites in 24-hour urine measure: Interstitial glucose profile measure: Physical activity measure: Fecal microbiome composition measure: Fasting and postprandial circulating metabolites with a high fat mixed meal (HFMM) challenge measure: Oral microbiome composition measure: Microbiome metabolites measure: Microbiome functionality measure: Self-reported gastro-intestinal symptoms measure: Self-reported constipation measure: Self-reported stool consistency and frequency measure: Gastro-intestinal transit time measure: Self reported product-specific attitude towards meat and PBMAs measure: Self reported meal-specific satiety with meat and PBMAs measure: Self-reported general attitude toward meat and PBMAs measure: Body composition measure: Genetic variation measure: Oral glucose tolerance test (OGTT) measure: Habitual dietary intake measure: Perceived stress measure: Chronotype assessment measure: Sleeping habits measure: Self reported habitual meat and PBMA consumption measure: 24-hour dietary recall measure: Home environment microbiome composition sex: ALL minimumAge: 45 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Wageningen University, Division of Human Nutrition status: RECRUITING city: Wageningen state: Gelderland zip: 6708 WE country: Netherlands lat: 51.97 lon: 5.66667 hasResults: False