nctId: NCT06290271 id: CISTAR briefTitle: Arterial Wall Shear Stress After Intracranial Artery Recanalization overallStatus: RECRUITING date: 2023-08-01 date: 2024-06 date: 2024-12 date: 2024-03-04 date: 2024-03-04 name: Chonbuk National University Hospital class: OTHER name: Seoul National University Hospital name: Chungnam National University Hospital name: Asan Medical Center name: Chonnam National University Hospital name: Korea University Ansan Hospital name: SMG-SNU Boramae Medical Center briefSummary: There has been consistent research on the cerebral blood flow features in ischemic stroke patients with acute occlusion of major intracranial arteries. However, studies analyzing the overall features of the major intracranial artery blood flow in the periods of pre and post-recanalization are still lacking. Time-of-flight magnetic resonance angiography (TOF-MRA) is extensively utilized to evaluate the intracranial arteries. The arterial signal intensity from MRA-TOF varies across subjects and arterial subtypes, leading to the development of the Signal Intensity Gradient (SIG) concept. SIG has demonstrated a strong correlation with Computational Fluid Dynamics (CFD), a known method for reflecting wall shear stress. SIG could be associated with the pathophysiology of wall shear stress. We aim to investigate the blood flow patterns and characteristics in the periods of pre and post-recanalization using SIG. conditions: Intracranial Artery Occlusion studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: OTHER count: 160 type: ESTIMATED name: Intracranial artery flow pattern measure: Neurological Severity at discharge sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Korea University Ansan Hospital status: NOT_YET_RECRUITING city: Ansan state: Gyeonggi-do zip: 15355 country: Korea, Republic of name: Sang-Heon Lee, Prof. role: CONTACT email: huny0029@naver.com lat: 37.32361 lon: 126.82194 facility: Jeonbuk National University Hospital status: NOT_YET_RECRUITING city: Jeonju state: Jeollabuk Do zip: 54907 country: Korea, Republic of name: Hyo Sung Kwak, Prof. role: CONTACT email: kwakhs8140@gmail.com lat: 35.82194 lon: 127.14889 facility: Chungnam National University Hospital status: RECRUITING city: Daejeon zip: 35015 country: Korea, Republic of name: Hee Jung Song, Prof. role: CONTACT email: nrsono@naver.com lat: 36.32139 lon: 127.41972 facility: Chonnam National University Hospital status: RECRUITING city: Gwangju zip: 61469 country: Korea, Republic of name: Man-Seok Park, Prof. role: CONTACT email: mspark@chonnam.ac.kr lat: 35.15472 lon: 126.91556 facility: Seoul National University Hospital status: NOT_YET_RECRUITING city: Seoul zip: 03080 country: Korea, Republic of name: Keun-Hwa Jung, Prof. role: CONTACT email: jungkh@gmail.com lat: 37.566 lon: 126.9784 facility: Asan Medical Center status: RECRUITING city: Seoul zip: 05505 country: Korea, Republic of name: Beom-Jun Kim, Prof. role: CONTACT email: medicj80@hanmail.net lat: 37.566 lon: 126.9784 facility: SMG-SNU Boramae Medical Center status: NOT_YET_RECRUITING city: Seoul zip: 07061 country: Korea, Republic of name: Yong-Seok Lee, Prof. role: CONTACT email: mercades@snu.ac.kr lat: 37.566 lon: 126.9784 facility: Ulsan University Hospital status: RECRUITING city: Ulsan zip: 44033 country: Korea, Republic of name: Chan-Hyuk Lee, Prof. role: CONTACT email: bluewave0210@gmail.com lat: 35.53722 lon: 129.31667 hasResults: False