hackint0sh/New-Dataset huggingface dataset:
2. Long-term Post-bleaching shade stability. For Patients treated with 40% hydrogen-peroxide bleaching agent. primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: This clinical trail was a double blinded trail in which the participant and outcome assessor were blinded to allocation, thus the participant was unaware of which experimental material had been assigned to him/her. Also outcome assessors were blinded to the treatment that each participant had received whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 60 type: ACTUAL name: Poly amido amine dendrimer (PAMAM) name: Manufacturer's desensitizing agent, Ultra EZ name: MI paste plus, desensitizing agent name: Hydroxyapatite and F (ReminPro), desensitizing agent measure: Post-bleaching dental hypersensitivity measure: Shade stability sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Faculty of Dentistry - Ain Shams University city: Cairo state: El Weili zip: 4393005 country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06358898 id: 20221207 briefTitle: Digital Mood-enhanced CBT-I to Improve Depressive Symptoms in Adolescents overallStatus: NOT_YET_RECRUITING date: 2024-04-18 date: 2026-05-31 date: 2026-12-31 date: 2024-04-11 date: 2024-04-12 name: Chinese University of Hong Kong class: OTHER briefSummary: Emerging encouraging evidence showed that sleep focused treatment can simultaneously improve sleep and depression in adult with comorbid conditions. Although these favorable changes in depressed adults is encouraging, little is known in the potential efficacy of CBT-I in altering depression trajectory in adolescent population. This current study aims to compare the effect of digitally delivered, mood enhanced cognitive behavioral therapy for insomnia (M-dCBT-I) and standard digital cognitive behavioral therapy for insomnia (dCBT-I) in improving depressive symptoms in adolescents, and to examine the potential sustained treatment effect in mood outcomes following M-dCBT-I or dCBT-I treatment. conditions: Insomnia conditions: Depression conditions: Adolescent studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 343 type: ESTIMATED name: Standard dCBT-I name: Modified Mood enhanced CBT-I (M-dCBT-I) measure: Depressive symptoms measure: Assessor-rated depressive symptomatology measure: Overall severity of depression symptoms measure: Severity of insomnia symptoms measure: Sleep-wake pattern measure: Sleep-related beliefs and cognitions measure: Daytime sleepiness measure: Anxiety and depression symptoms measure: Quality of life by KIDSCREEN-27 measure: Major life events and self-perceived stress measure: Chronotype measure: Pubertal status sex: ALL minimumAge: 12 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Department of Psychiatry, the Chinese University of Hong Kong city: Sha Tin state: New Territories country: Hong Kong lat: 22.38333 lon: 114.18333 hasResults: False
nctId: NCT06358872 id: 23-39839 briefTitle: Azithromycin for Child Survival in Niger II acronym: AVENIR II overallStatus: NOT_YET_RECRUITING date: 2024-04-29 date: 2028-04-29 date: 2028-04-29 date: 2024-04-11 date: 2024-04-12 name: University of California, San Francisco class: OTHER name: Centre de recherche et interventions en santé publique (CRISP) name: Ministère de la Santé Publique du Niger name: Le Programme National de Santé Oculaire name: Centre de Recherche Médicale et Sanitaire name: Bill and Melinda Gates Foundation briefSummary: Several randomized controlled trials have demonstrated that azithromycin mass drug administration (MDA) reduces child mortality, but increases antimicrobial resistance (AMR). The World Health Organization (WHO) guidelines for this intervention specify that implementation must be accompanied by continued monitoring of mortality and AMR. Niger is expanding the azithromycin MDA program nationwide. To establish monitoring of mortality and AMR as part of this program as well as to leverage the infrastructure to evaluate other child health interventions, AVENIR II is designed as an adaptive platform trial with monitoring and re-randomization every 2 years. conditions: Mortality conditions: Antimicrobial Resistance studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The intervention will involve biannual oral azithromycin MDA to children 1-59 months old distributed by community health workers. The Centre de Santé Integré (CSI) will be randomized to receive azithromycin MDA or delayed treatment in a stepped wedge design for the first 2 years. The delayed intervention arm will receive usual care for the first 2 years, then will receive the intervention for the next 2 years. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Participants, community health workers delivering the intervention, and team members supervising the program will not be masked. One biostatistician and one data analyst will remain unmasked to prepare the randomization sequence. Masked personnel include outcome assessors as well as the biostatistician and data analyst conducting the data analyses. whoMasked: OUTCOMES_ASSESSOR count: 3300000 type: ESTIMATED name: Azithromycin for Oral Suspension measure: All-cause mortality measure: All-cause mortality measure: Prevalence of resistance to macrolides - nasopharyngeal swabs measure: Prevalence of resistance to macrolides - nasopharyngeal swabs measure: Load of genetic determinants of resistance to macrolides - rectal swabs measure: Load of genetic determinants of resistance to macrolides - rectal swabs measure: Number of clinic visits - infectious measure: Number of clinic visits - infectious measure: Prevalence of Genetic Determinants of resistance - Nasopharyngeal swabs measure: Prevalence of Genetic Determinants of resistance - Nasopharyngeal swabs measure: Program Cost Per Dose Delivered sex: ALL minimumAge: 1 Month maximumAge: 59 Months stdAges: CHILD facility: Program National de Santé Oculaire city: Niamey country: Niger lat: 13.51366 lon: 2.1098 hasResults: False
nctId: NCT06358846 id: 00004 briefTitle: Effectiveness of Educational Intervention on Footcare Among Individuals Having Type 2 Diabetes at Slums of Karachi, Pakistan. overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2024-07-15 date: 2024-07-31 date: 2024-04-11 date: 2024-04-12 name: SINA Health Education and Welfare Trust class: OTHER name: Aga Khan University briefSummary: There are multiple studies conducted in Pakistan that supports the topic of foot care knowledge among individual with type 2 diabetes but all are descriptive cross-sectional studies and investigators cannot develop cause effect relationship out of it. Secondly, there is a lack of documented research on the foot care knowledge shown by people with T2D residing in the slums of Karachi. In order to assess the knowledge intervention among the individual having T2D through qualified diabetes educators and pictorial educational pamphlet along with the standard care of treatment. Consequently, it may aid in the development of effective methods aimed at mitigating foot-related complications among this specific population. Individuals diagnosed with diabetes are required to engage in proactive and structured self-care activities by providing the foot care knowledge in order to effectively manage their condition and mitigate the risk of potential complications. The incorporation of health-deviation knowledge and activities into routine is crucial. conditions: Diabetic Foot conditions: Educational Intervention conditions: Foot Care conditions: Foot Ulcer, Diabetic conditions: Foot Cellulitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Control arm =75 Interventional arm = 75 primaryPurpose: PREVENTION masking: NONE count: 150 type: ESTIMATED name: Self-care behavior to promote foot care through educational guidance among individual with diabetes measure: Improved Foot Care Knowledge measure: Behavior Change measure: Reduction in Foot Complications measure: Empowerment and Self-efficacy sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06358833 id: 24-82-03 briefTitle: Comparison of Endodontic Postoperative Pain Using Different Irrigation Systems overallStatus: RECRUITING date: 2024-04-15 date: 2024-12-31 date: 2024-12-31 date: 2024-04-11 date: 2024-04-18 name: Qassim University class: OTHER briefSummary: Summary:
After a root canal procedure, it is common to experience postoperative pain. Cleaning the root canal thoroughly is crucial for pain relief, but removing all debris with standard methods is difficult. Irrigation, using either traditional endodontic needles or newer methods like endodontic activation, helps clean the canal. This study aims to compare pain levels after using conventional needles versus an Endo1 Ultrasonic Endo Activate Device for irrigation. Patients will undergo standard root canal preparation and then be randomly assigned to one of two groups for final irrigation: the Endo1 device (EA) and the conventional endodontic needles (EN). The study will provide insights into which method is more effective in reducing postoperative pain. conditions: Postoperative Pain conditions: Irreversible Pulpitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Patients will be masked from the procedure whoMasked: PARTICIPANT count: 34 type: ESTIMATED name: endodontic needle (EN) name: Endodontic activation (EA) measure: Postoperative pain measure: Postoperative pain measure: Postoperative pain measure: Postoperative pain measure: Irrigation time measure: Adverse event measure: Rescue medication sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Muhammad Zubair Ahmad status: RECRUITING city: Ar Rass state: Qassim zip: 58883 country: Saudi Arabia name: Muhammad Zubair Ahmad, BDS, FCPS role: CONTACT phone: 0163011111 phoneExt: 10685 email: m.muhammad@qu.edu.sa lat: 25.86944 lon: 43.4973 hasResults: False
nctId: NCT06358820 id: PHGaozhou briefTitle: Exploring the Effectiveness and Safety of Amino Acid Peritoneal Dialysis Solution overallStatus: RECRUITING date: 2023-12-03 date: 2025-01 date: 2025-07 date: 2024-04-11 date: 2024-04-11 name: The People's Hospital of Gaozhou class: OTHER briefSummary: This study adopts a multicenter, open, prospective, and self controlled study design, in which each participant serves as their own control before and after receiving amino acid peritoneal dialysis solution treatment to compare changes in their nutritional status. Each subject received treatment with 1 bag of amino acid peritoneal dialysis per day and 2-4 bags of glucose peritoneal dialysis solution per day for 6 months (the amount of glucose peritoneal dialysis solution used was determined based on the treatment plan selected by the patient during the screening period when they entered the study).Before treatment and during the 3rd and 6th months of treatment, subjects were evaluated for various efficacy and safety indicators, and any adverse or serious adverse events were recorded. conditions: Exploring the Effectiveness and Safety of Amino Acid Peritoneal Dialysis Solution in Improving Nutritional Status of Maintenance Peritoneal Dialysis Patients studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 140 type: ESTIMATED name: Amino acid peritoneal dialysis solution measure: blood albumin measure: prealbumin sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Gaozhou People's Hospital status: RECRUITING city: Gaozhou state: Guangdong zip: 525200 country: China name: Deng shanshan role: CONTACT phone: 8613927596600 email: 276531255@qq.com lat: 21.93924 lon: 110.84607 hasResults: False
nctId: NCT06358807 id: M2023438 briefTitle: Microfracture With Platelet Rich Plasma Gel Injection for Ostechondral Lesion of the Talus overallStatus: RECRUITING date: 2024-01-01 date: 2025-01-01 date: 2026-12-31 date: 2024-04-11 date: 2024-04-11 name: Peking University Third Hospital class: OTHER briefSummary: The goal of this clinical trial is to learn if combined local injection of platelet rich plasma (PRP) gel adds clinical efficacy to isolated arthroscopic microfracture in treatment of osteochondral lesion of the talus (OLT). The interface integration of the injured area will also be assessed via radiographic follow-up. The main questions it aims to answer are:
* Take MRI preoperatively and 6, 12 and 24 months after surgery conditions: Osteochondral Lesion of Talus conditions: Microfractures conditions: Platelet Rich Plasma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 70 type: ESTIMATED name: Arthroscopic microfracture with intraoperative local PRP gel injection name: Isolated microfracture measure: American Orthopedic Foot and Ankle Society Score (AOFAS) measure: Foot and Ankle Outcome Score (FAOS) measure: Ankle Activity Score (AAS) measure: Visual Analogue Scale (VAS) measure: Patient Satisfaction measure: Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) measure: Return-to-Sport Rate measure: Complications sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Peking University Third Hospital status: RECRUITING city: Beijing country: China name: Guo Qinwei role: CONTACT lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06358794 id: IRB00006761-M2022692 briefTitle: Machine Learning Based-Personalized Prediction of Sperm Retrieval Success Rate overallStatus: COMPLETED date: 2022-06-01 date: 2022-12-31 date: 2023-05-31 date: 2024-04-11 date: 2024-04-11 name: Peking University Third Hospital class: OTHER briefSummary: Non-obstructive azoospermia (NOA) stands as the most severe form of male infertility. However, due to the diverse nature of testis focal spermatogenesis in NOA patients, accurately assessing the sperm retrieval rate (SRR) becomes challenging. The current study aims to develop and validate a noninvasive evaluation system based on machine learning, which can effectively estimate the SRR for NOA patients. In single-center investigation, NOA patients who underwent microdissection testicular sperm extraction (micro-TESE) were enrolled: (1) 2,438 patients from January 2016 to December 2022, and (2) 174 patients from January 2023 to May 2023 (as an additional validation cohort). The clinical features of participants were used to train, test and validate the machine learning models. Various evaluation metrics including area under the ROC (AUC), accuracy, etc. were used to evaluate the predictive performance of 8 machine learning models. conditions: Infertility, Male conditions: Azoospermia, Nonobstructive studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 2612 type: ACTUAL name: Machine learning-based predictive model measure: SRR of micro-TESE sex: MALE minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Peking University Third Hospital city: Beijing state: Beijing zip: 100191 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06358781 id: xuyajun197673-002 briefTitle: A Dose-response Study to Validate the Biomarkers for Whole Grain Dietary Intake overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2024-05-30 date: 2024-06-30 date: 2024-04-11 date: 2024-04-11 name: Peking University class: OTHER briefSummary: Dose-response validation of whole grain dietary intake biomarkers remains limited, and it is debatable whether these markers could be utilized as classifiers for different levels of whole grain consumption. Because there are significant disparities in genetic background and dietary patterns between Chinese and Western cultures, it is unclear if whole grain dietary intake biomarkers can characterize whole grain consumption in Chinese populations. To address these issues, the current study was designed to evaluate the sensitivity and specificity of potential whole grain markers in a randomized controlled trial, as well as to validate the markers' dose-response relationship, so that they can be used in nutritional epidemiological studies and dietary intake assessments of whole grains. conditions: Chronic Disease Prevention studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: NONE count: 48 type: ESTIMATED name: Whole grain wheat flour measure: whole grain plasma and urine biomarkers discovery and identification measure: Validate the performance of the potential WG biomarkers. measure: Dose-response of WG wheat biomarkers. sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Department of Nutrition and Food Hygiene, School of Public Health, Peking University city: Beijing country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06358768 id: ObGynEASC005 briefTitle: Post-Partum Haemorrhage (PPH) Improvement of Skills With Actor Simulations acronym: PPH overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-07-31 date: 2024-09-30 date: 2024-04-11 date: 2024-04-16 name: G. d'Annunzio University class: OTHER name: A.O. Ospedale Papa Giovanni XXIII briefSummary: Pre test and post test questionnaire for evaluation of skills and teamwork capacities in PPH management conditions: PPH - Postpartum Hemorrhage studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: teamwork job improvement overall name: teamwork job improvement in actor scenario vs mannequin scenario measure: teamwork measure: skills measure: scenario quality sex: ALL minimumAge: 19 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Claudio Celentano city: Pescara state: PE zip: 65100 country: Italy name: Claudio Celentano, MD role: CONTACT phone: +393285577305 email: celentanoclaudio70@gmail.com lat: 42.4584 lon: 14.20283 facility: Ospedale Giovanni XXIII city: Bergamo country: Italy name: Luisa Patanè, MD role: CONTACT phone: 349 3503920‬ phoneExt: +39 email: luisapatane@me.com lat: 45.69601 lon: 9.66721 hasResults: False
nctId: NCT06358755 id: 10211476 id: P0041308 type: OTHER domain: The Hong Kong Polytechnic University briefTitle: Combination Effect of Optical Defocus and Low Dose Atropine in Myopia Control overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-04-30 date: 2026-10-31 date: 2024-04-11 date: 2024-04-11 name: The Hong Kong Polytechnic University class: OTHER name: The University of Hong Kong briefSummary: The purpose of the study is to investigate the combination effect of optical defocus and low dose atropine on myopia control in schoolchildren. conditions: Myopia studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Eligible participants will be randomly allocated into 2 groups. One group will receive low dose atropine (0.01%) plus DIMS spectacles (ATD Group); another one will receive low dose atropine (0.01%) plus single vision spectacles (AT Group). primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Investigators, including ophthalmologists and optometrists, who are responsible for collection of data related to myopia progression and analysis of data will be blinded to study intervention. whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 112 type: ESTIMATED name: Defocus Incorporated Multiple Segments lenses name: single vision spectacle lenses name: Low dose atropine measure: Changes in cycloplegic refraction measure: Changes in axial length sex: ALL minimumAge: 7 Years maximumAge: 12 Years stdAges: CHILD facility: Centre for Myopia Research, The Hong Kong Polytechnic University and Department of Ophthalmology, The University of Hong Kong city: Hong Kong zip: No postcode country: Hong Kong name: Rachel Ka Man Chun, PhD role: CONTACT phone: +852-27664224 email: rachel.chun@polyu.edu.hk name: Dennis Yan-yin Tse, PhD role: CONTACT phone: +852-27666096 email: dennis.tse@polyu.edu.hk name: Christopher Kai-shun Leung, MD and Prof role: PRINCIPAL_INVESTIGATOR lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06358742 id: ORL-GUM-2787 briefTitle: Evaluation of the Effect of Zinc Citrate Trihydrate Toothpaste on the Oral Plaque Microbiome overallStatus: COMPLETED date: 2017-01-10 date: 2017-05-19 date: 2017-05-19 date: 2024-04-11 date: 2024-04-11 name: Unilever R&D class: INDUSTRY name: Intertek briefSummary: This study is of a double-blind, randomised, parallel group study. Subjects will be enrolled onto the study according to the inclusion/exclusion criteria. After recruitment, subjects will be given a fluoride toothpaste without gum care agents to use for the 4-week run-in period prior to the commencement of the test phase of the study. Following the run-in period, baseline supragingival plaque samples will be collected 12 hours after last brushing, from the upper and lower jaws separately. Subjects will then then randomly allocated to one of two products (zinc citrate trihydrate \[ZCT\] toothpaste or control toothpaste) according to the randomization. Subjects will be instructed to use the toothpaste at home, brushing twice a day for 12-weeks. Supragingival plaque samples will be collected again from the upper and lower jaws after 2, 6 and 12 weeks. Plaque samples will then undergo metataxonomic and metatranscriptomic analyses. conditions: Dental Plaque studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: TRIPLE maskingDescription: Toothpaste packaged in white tubes with a study label which only differentiates products with a alphanumeric code. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 142 type: ACTUAL name: ZCT toothpaste name: Control toothpaste measure: Plaque microbiome sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06358729 id: HUM00239775 briefTitle: Pre-Pregnancy Weight Loss and Baby Behavior Study overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2027-04 date: 2024-04-11 date: 2024-04-11 name: University of Michigan class: OTHER briefSummary: This study will help researchers learn more about how babies respond to bottle nipples with larger or smaller holes. Researchers guess that infants of mothers with obesity who did not lose weight prior to pregnancy will have the greatest Suck Effect on the challenging compared with the typical nipple. conditions: Obesity; Familial conditions: Pregnancy Related conditions: Infant Behavior studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: SINGLE maskingDescription: Order of nipple size use is counter-balanced, caregivers are blind to nipple size and amount of milk in the bottle (i.e., the bottle is covered) to minimize their influence over the infant's consumption. Research assistants will not be blind to nipple size as they will need to set the bottles ups for the mothers. whoMasked: PARTICIPANT count: 30 type: ESTIMATED name: Typical Nipple name: Challenging Nipple measure: Suck effect measure: Sucking pressure measure: Sucking frequency measure: Milk/Formula intake measure: Milk/Formula consumption rate measure: Number of Feedings Over 24 Hours measure: Total Hours of Sleep per 24 Hours within 24 hours of intervention measure: Total Night Wake-ups within 24 hours of intervention sex: ALL minimumAge: 3 Months stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: The University of Michigan city: Ann Arbor state: Michigan zip: 48109 country: United States name: Amanda Crandall, PhD role: CONTACT name: Amanda Crandall, PhD role: PRINCIPAL_INVESTIGATOR lat: 42.27756 lon: -83.74088 hasResults: False