hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06353945 id: HB062-24 briefTitle: Perceived Effectiveness of the Vaginal Moisturizer Investigational Product Under Normal Conditions of Use. overallStatus: NOT_YET_RECRUITING date: 2024-04-29 date: 2024-05-07 date: 2024-05-15 date: 2024-04-09 date: 2024-04-09 name: Herbarium Laboratorio Botanico Ltda class: INDUSTRY briefSummary: The present research project aims to evaluate the perceived effectiveness of the product under investigation under normal conditions of use for 28 days, to defend the claims "High hydration power, relief of discomfort and improvement of vaginal tone." conditions: Vaginal Atrophy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 45 type: ESTIMATED name: vaginal moisturizer measure: evaluate the perceived effectiveness of the investigational product sex: FEMALE minimumAge: 25 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06353932 id: KA-23026 briefTitle: The Effect of Monitoring Endotracheal Tube Cuff Pressure and Keeping it in a Certain Range overallStatus: COMPLETED date: 2024-01-25 date: 2024-02-25 date: 2024-02-25 date: 2024-04-09 date: 2024-04-09 name: Hacettepe University class: OTHER briefSummary: The main purpose of our prospective, randomized, controlled, double-blind study is to investigate the effect of keeping endotracheal tube cuff pressures within a certain range on the incidence of postoperative sore throat, hoarseness and cough.The secondary aims of our study are to evaluate the effect of intubation duration, smoking, presence of chest disease, presence of blood on the intubation tube after extubation, presence of NG\\OG, and type of surgery on the incidence of sore throat, hoarseness, and cough.The patients were randomly divided into two: a study group with continuous cuff pressure monitoring and a control group without continuous cuff pressure monitoring.The endotracheal cuff pressure of the patients in both groups was measured by a blinded researcher using a cuff manometer after intubation, before extubation, and in long cases, at the 3rd hour after intubation.Patients were evaluated for sore throat, cough, and hoarseness at the 2nd and 24th hours by another researcher blinded to the study groups. conditions: Endotracheal Tube conditions: Cuff Pressure conditions: Sore Throat studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 263 type: ACTUAL name: keeping the endotracheal tube cuff pressure within a certain range measure: Sore throat measure: cough measure: hoarseness sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hacettepe University Hospital city: Ankara zip: 06100 country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06353919 id: NUNM briefTitle: Remote Yoga Nidra for Deprescribing BZRAs overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-05-31 date: 2025-05-31 date: 2024-04-09 date: 2024-04-09 name: National University of Natural Medicine class: OTHER name: US Department of Veterans Affairs briefSummary: The overall goal of this application is to assess feasibility and impact of a remotely delivered guided meditation practice called Yoga Nidra, for reducing or stopping use of Benzodiazepine Receptor Agonists (BZRAs) for insomnia and anxiety in a population of older adults recruited from within the Birmingham VA medical system. conditions: Anxiety conditions: Insomnia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 40 type: ESTIMATED name: Yoga Nidra name: Sleep Hygiene, Anxiety, and Benzodiazepine Receptor Agonist Education measure: Demand measure: Recruitment Success measure: Implementation practicality measure: Acceptability measure: Retention measure: Adherence to Protocol measure: Use of Benzodiazepine Receptor Agonist medications measure: Cessation of Benzodiazepine Receptor Agonist medication measure: Baseline Urine Benzodiazepine Receptor Agonist Concentration measure: Close-out Urine Benzodiazepine Receptor Agonist Concentration measure: Insomnia Severity Index measure: Insomnia Severity Index measure: Insomnia Severity Index measure: Insomnia Severity Index measure: Patient reported outcomes measurement information system 29 measure: Patient reported outcomes measurement information system 29 measure: Generalized Anxiety Disorder 7 Questionnaire measure: Generalized Anxiety Disorder 7 Questionnaire sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT hasResults: False
nctId: NCT06353906 id: N22APC briefTitle: Carboplatin/Paclitaxel + Pembrolizumab for Locoregionally Advanced Penile Cancer acronym: PRIAM overallStatus: NOT_YET_RECRUITING date: 2024-06-14 date: 2026-10-14 date: 2028-01-14 date: 2024-04-09 date: 2024-04-09 name: The Netherlands Cancer Institute class: OTHER name: Merck Sharp & Dohme LLC briefSummary: This is a single-armed, single-centre, non-blinded phase II trial to assess efficacy of induction chemo-immunotherapy for resectable node-positive squamous cell carcinoma of the penis conditions: Urologic Neoplasms conditions: Urogenital Neoplasms conditions: Male Urogenital Diseases conditions: Penile Cancer conditions: Penile Squamous Cell Carcinoma conditions: Locally Advanced Penile Carcinoma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 27 type: ESTIMATED name: Carboplatin/Paclitaxel name: Pembrolizumab name: Partial or total penectomy with inguinal and/or pelvic lymph node dissection measure: Pathological complete response (pCR) measure: Drug toxicity measure: Progression-free survival (PFS) measure: Overall survival (OS) measure: Assessment of correlation between clinical endpoints and tumor characteristics measure: Tumor tissue HPV status in relation to treatment response measure: Tumor tissue PD-L1 expression in relation to treatment response measure: Evaluation of changes in patient reported outcome regarding Quality of Life (QoL) sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06353893 id: Integrity-001 briefTitle: MRI Evaluation of Integrity Bio-Inductive Implant for Rotator Cuff Tears overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-12-01 date: 2026-05-01 date: 2024-04-09 date: 2024-04-09 name: Foundation for Orthopaedic Research and Education class: OTHER name: Anika Therapeutics, Inc. briefSummary: The goal of this observational study is to evaluate the effectiveness and safety of the Integrity bio-inductive implant in treating partial and full thickness rotator cuff tears. The main questions it aims to answer are:
Postoperative MRIs will be obtained from 10 consecutive patients who have undergone rotator cuff repair using the Integrity implant at 3 and 6 months after surgery. Participants include those with partial and full thickness tears treated with different surgical techniques involving the implant. They may receive either isolated onlay use of the graft for partial tears or augmentation of a standard single or double row repair with the graft applied to the superior surface of the repair. conditions: Rotator Cuff Tears studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 10 type: ESTIMATED name: Anika Integrity Implant System measure: MRI Assessment of Adverse Events and Structural Integrity measure: Effectiveness Evaluation with PROMIS outcome tool measure: Effectiveness Evaluation with PROMIS tool measure: Effectiveness Evaluation with SANE score measure: Effectiveness Evaluation with SANE score measure: Effectiveness Evaluation with ASES rating scale measure: Effectiveness Evaluation with ASES rating scale sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Foundation for Orthopaedic Research and Education city: Tampa state: Florida zip: 33607 country: United States lat: 27.94752 lon: -82.45843 hasResults: False
nctId: NCT06353880 id: 24K08-001 briefTitle: Obesity With Sperm Quality in Men With Fertility Need overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-06 date: 2025-12 date: 2024-04-09 date: 2024-04-09 name: Yu xiaowei class: OTHER briefSummary: This study aims to investigate the impact of different types of obesity on sperm quality. Participants will be divided into three groups: a normal BMI group, an obese group without pudendal fat wrapping the testicles, and an obese group with pudendal fat wrapping the testicles. Sperm quality parameters will be compared among these groups to assess potential differences associated with different types of obesity. conditions: Sperm Quality conditions: Obesity conditions: Sex Hormones conditions: Visceral Fat studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 2000 type: ESTIMATED name: Participants will be categorized into three groups based on BMI and the presence of pudendal fat deposition. measure: Investigation of Testicular Fat-Wrapped Testes Incidence and Associated Risk Factors measure: Comparison of Sperm Quality Across BMI Categories and Testicular Fat-Wrapped Subgroups measure: Comparison of Sex Hormone Levels Across BMI Categories and Testicular Fat-Wrapped Subgroups sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06353867 id: 56365223-050.01.04-2023.13754 briefTitle: The Effect of Group Exercise in Children With Special Needs overallStatus: COMPLETED date: 2022-12-27 date: 2023-04-15 date: 2023-04-25 date: 2024-04-09 date: 2024-04-09 name: Istanbul Gedik University class: OTHER briefSummary: Thirty children with special needs were included in the study. Participants engaged in group exercises twice a week for four weeks, including warm-up and cool-down periods, with the goal of improving balance. The participants' balance was assessed using the Bruininks-Oseretsky Motor Proficiency Test Short Form (Balance Parameters), Pediatric Balance Scale; functional mobility was evaluated using the Timed Up and Go Test, and attention level was assessed using the Stroop Test before and after the intervention. conditions: Developmental Disability conditions: Child Autism studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 30 type: ACTUAL name: Group Exercise measure: Bruininks-Oseretsky Motor Competence Test Short Form Balance Subtest (Balance Subtest of BOT 2-KF) measure: Paediatric Balance Scale measure: Functional Reach Test measure: Timed Up and Go Test measure: Stroop Test sex: ALL minimumAge: 6 Years maximumAge: 15 Years stdAges: CHILD facility: Marmara University city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06353854 id: FFCD 2112-CORESIM briefTitle: Prospective Cohort Study of Immunotherapy Resistance in Metastatic Colorectal Cancer Patients With MSI acronym: CORESIM overallStatus: RECRUITING date: 2024-02-12 date: 2029-02-12 date: 2030-02-12 date: 2024-04-09 date: 2024-04-09 name: Federation Francophone de Cancerologie Digestive class: OTHER briefSummary: Over the last ten years, the discovery of the mechanisms by which tumours escape the control of the immune system, and in particular the T lymphocyte response, has led to the emergence of new therapeutic strategies against cancer, such as the use of "immune checkpoint inhibitors" (ICI). The immune system plays a crucial role in controlling tumour proliferation, and involves several players.
Schematically, after recognition of the MHC-peptide complex by the TCR, the T lymphocyte response is modulated by several activating or inhibiting co-stimulatory signals (or "checkpoints"). The balance of these different signals determines whether the T lymphocyte (LT) is activated, resulting in the destruction of the target cell, or whether the T lymphocyte is inhibited (anergy), inducing immune tolerance. By hijacking this system through the expression of inhibitory checkpoints on its surface, the tumour cell is able to evade the effector immune response (1). Monoclonal antibodies (mAbs) directed against inhibitory co-stimulatory molecules such as Programmed-cell death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) or their ligand Programmed-cell death ligand 1 (PD-L1) have been developed to restore effective anti-tumour immunity. These ICIs have led to a major improvement in the prognosis of certain cancers, notably melanoma and non-small cell lung cancer.
nctId: NCT06353841 id: 2023/435 briefTitle: Effect of Therapeutic Touch on Functional Constipation in Infants and Young Children overallStatus: RECRUITING date: 2023-05-03 date: 2024-05-01 date: 2024-12-31 date: 2024-04-09 date: 2024-04-09 name: Burdur Mehmet Akif Ersoy University class: OTHER briefSummary: The aim of the study is to determine the effect of therapeutic touch on functional constipation in infants and young children. conditions: Functional Constipation conditions: Therapeutic Touch conditions: Infants conditions: Children conditions: Constipation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: The data analyst will be blinded to the procedure and results of randomization, group allocation, and intervention. whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Therapeutic Touch measure: Primary Results Follow-up Form measure: Primary Results Follow-up Form measure: Primary Results Follow-up Form measure: Primary Results Follow-up Form measure: Primary Results Follow-up Form measure: Primary Results Follow-up Form measure: Bristol Stool Scale sex: ALL minimumAge: 6 Months maximumAge: 24 Months stdAges: CHILD facility: Burdur Bucak State Hospital status: RECRUITING city: Burdur state: Bucak zip: 15030 country: Turkey name: Selda Ateş Beşirik, PhD. role: CONTACT phone: +905076228189 email: seldaates07@gmail.com name: Selda Ateş Beşirik, PhD. role: PRINCIPAL_INVESTIGATOR name: Emine Geçkil, Prof. role: SUB_INVESTIGATOR lat: 37.72028 lon: 30.29083 hasResults: False
nctId: NCT06353828 id: ICBD-UC-01 briefTitle: Phase 2a Study to Evaluate IcBD-01 Enema in Active Ulcerative Colitis Patients overallStatus: ACTIVE_NOT_RECRUITING date: 2023-03-01 date: 2024-04-01 date: 2025-04-01 date: 2024-04-09 date: 2024-04-09 name: CannaMore Biotechs class: INDUSTRY briefSummary: Ulcerative proctitis can lead to considerable morbidity, and the available treatment options are limited. Cannabidiol (CBD), a non-psychotropic ingredient of Cannabis sativa, possesses potent immunomodulatory and anti-inflammatory properties as described in both acute and chronic animal models of inflammation, including IBD models.
Based on positive safety and initial efficacy profiles of CBD found in IBD animal and clinical studies, the main aim of this study is to evaluate the safety, tolerability and efficacy of a novel enema formulation of CBD for the treatment of active ulcerative proctitis. conditions: Ulcerative Colitis studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 45 type: ESTIMATED name: CBD, synthetic form name: Placebo measure: Change from baseline in Full Mayo Score measure: Change in Partial Mayo Score measure: Change in patient reported outcome (PRO-UC) measure: Change in endoscopic Mayo subscore in distal 15 cm of anus measure: Change in the length of the inflamed colon sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Meir Medical Center city: Kfar Saba country: Israel lat: 32.175 lon: 34.90694 hasResults: False
nctId: NCT06353815 id: anaesthetic efficacy briefTitle: Clinical Evaluation of Anaesthetic Efficacy of 4% Articaine Buccal Infiltration Versus Inferior Alveolar Nerve Block overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2025-02 date: 2025-06 date: 2024-04-09 date: 2024-04-09 name: Cairo University class: OTHER briefSummary: Clinical evaluation of anaesthetic efficacy of 4% articaine buccal infiltration versus inferior alveolar nerve block during restorative dental treatment in mandibular first permanent molars conditions: Restorative Dental Treatment by Buccal Infiltration Anaesthesia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 44 type: ESTIMATED name: 4% articaine infiltration measure: Success of local anesthesia measure: Child behavior during treatment sex: ALL minimumAge: 6 Years maximumAge: 9 Years stdAges: CHILD hasResults: False
nctId: NCT06353802 id: P.T.REC/012/004963 briefTitle: Relationship Between Chronic Non-Specific Neck Pain And Lumbar Reposition Sense overallStatus: ACTIVE_NOT_RECRUITING date: 2023-09-01 date: 2024-04 date: 2024-05 date: 2024-04-09 date: 2024-04-09 name: Cairo University class: OTHER briefSummary: to investigate the correlation between chronic non-specific neck pain and lumbar reposition sense. conditions: Chronic Non-specific Neck Pain studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 67 type: ACTUAL name: Chronic non-specific neck pain and lumbar reposition sense measure: Correlation Between Chronic Non-Specific Neck Pain And Lumbar Reposition Sense Using iPhone inclinometer app sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Physical Therapy College Cairo University city: Giza zip: 12613 country: Egypt lat: 30.00808 lon: 31.21093 hasResults: False
nctId: NCT06353789 id: RoADPain Clinical Study briefTitle: Adolescent Dysmenorrhoea as a Risk Factor for Chronic Pain: Clinical Cohort Study acronym: RoADPain overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05-01 date: 2027-05-01 date: 2024-04-09 date: 2024-04-09 name: University of Oxford class: OTHER name: University of Exeter name: University of York name: Endometriosis UK briefSummary: This study aims to understand whether changes in a variety of body systems which are seen in adult women with period pain are also seen in adolescents in the first few years of having periods. This information will help us to understand 1) how quickly any changes occur, informing clinical practice, and 2) how period pain might lead to other types of chronic pain, potentially allowing development of preventative strategies. conditions: Dysmenorrhea studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 132 type: ESTIMATED measure: Quantitative Sensory Testing (QST) measure: Heart rate (HR) measure: Change in heart rate measure: Bladder sensitivity to filling measure: Volume voided at maximum tolerance measure: Pain Catastrophising: Pain Catastrophising Scale (PCS) (Sullivan) measure: Area under the curve (AUC) of single day salivary cortisol profile measure: Change of pressure pain threshold (PPT) measure: fMRI scan sex: FEMALE minimumAge: 11 Years maximumAge: 20 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06353776 id: 02052023 briefTitle: MicroPulse Transscleral Laser Therapy and Its Short-term Impact on Ocular Surface overallStatus: COMPLETED date: 2023-05-03 date: 2023-10-31 date: 2023-10-31 date: 2024-04-09 date: 2024-04-09 name: University Tunis El Manar class: OTHER briefSummary: MicroPulse transscleral laser therapy (TLT) is proven to be effective in reducing intraocular pressure with minimal complications in either primary or secondary glaucoma. However, its impact on the human ocular surface remains unexplored. This study aims to bridge this gap by examining the clinical and histopathological effects of MicroPulse TLT on the ocular surface. conditions: Conjunctiva conditions: Cornea studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 15 type: ACTUAL name: conjunctival biopsy after micropulse transscleral laser therapy measure: conjunctival inflammation or fibrosis measure: intraocular pression measure: ocular surface disease index score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mohamed Taher Maamouri Hospital city: Nabeul zip: 8000 country: Tunisia lat: 36.45606 lon: 10.73763 hasResults: False
nctId: NCT06353763 id: CV briefTitle: Design, Implementation, and Evaluation of Virtual Reality in the Nursing Curriculum overallStatus: COMPLETED date: 2022-02-24 date: 2022-05-30 date: 2022-06-30 date: 2024-04-09 date: 2024-04-09 name: Clinica Universidad de Navarra, Universidad de Navarra class: OTHER briefSummary: The aim of the study is to determine the effectiveness of an immersive virtual reality learning programme for nursing students, based on virtual glasses, in acquiring the competence (knowledge, skills and attitudes) to care for patients with pressure ulcers, and to compare it with the traditional teaching method.
The design was an exploratory randomised controlled trial. The variables used to measure effectiveness were competence and its attributes: knowledge assessment by a multiple-choice test (Pressure Ulcer Knowledge Assessment Tool, Pukat 2.0 instrument), skill performance by direct observation of procedural skills (simulated cases with standardised patients) and satisfaction and usability assessment (Usefulness, Satisfaction and Ease of Use Questionnaire). conditions: Pressure Ulcer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE maskingDescription: Participants were blinded in their group assignment. whoMasked: PARTICIPANT count: 127 type: ACTUAL name: Immersive virtual reality learning program measure: Knowledge measure: Skill performance measure: Usefulness, Satisfaction, and Ease of Use sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Navarra city: Pamplona state: Navarra country: Spain lat: 42.81687 lon: -1.64323 hasResults: False