hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06330467 id: 2023-A02442-43 id: RIPH 2023-02 type: REGISTRY domain: sponsor's internal reference briefTitle: Prevalence of Dissociative Identity Disorder in At-risk Outpatient Groups Reporting Childhood Trauma. acronym: IDENTITY overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-03-31 date: 2026-06-30 date: 2024-03-26 date: 2024-03-28 name: Centre Psychothérapique de Nancy class: OTHER briefSummary: The investigators will study the prevalence of dissociative identity disorder (DID) in three populations at risk in cases of childhood psychotrauma : patients with a diagnosis of borderline personality, patients with a diagnosis of functional dissociative crises (FDC) and patients with early psychosis.
Data collection will be done via a psychometric administration of 7 self-completion questionnaires as well as the completion of the SCID-D semi-structured interview. conditions: Dissociative Disorder studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 3 groups : borderline, early psychosis and FDC. primaryPurpose: DIAGNOSTIC masking: NONE count: 350 type: ESTIMATED name: psychometric assessment name: semi-structured clinical interview measure: SCID-D : Semi-structured Clinical Interview for diagnosing DSM-5 and ICD-11 Dissociative Disorders / DSM = Diagnostic and Statistical Manual of Mental Disorders / ICD = International Classification of Diseases measure: SCID-D : Semi-structured Clinical Interview for diagnosing DSM-5 and ICD-11 Dissociative Disorders measure: CTQ-28 : Childhood Trauma Questionnaire measure: life events inventory DSM-5 measure: PCL-5 : Posttraumatic stress disorder CheckList-5 measure: ITQ : International Trauma Questionnaire measure: SDQ-20 : Somatoform Dissociative questionnaire measure: DIS-Q : Dissociation Questionnaire measure: DES : Dissociative Experience Scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre Psychothérapique de Nancy - CLIP city: Nancy country: France name: Vincent LAPRÉVOTE role: CONTACT email: vincent.laprevote@cpn-laxou.com name: Vincent LAPRÉVOTE role: PRINCIPAL_INVESTIGATOR name: Lori PETROCELLI role: SUB_INVESTIGATOR lat: 48.68439 lon: 6.18496 facility: Centre Psychothérapique de Nancy - CMP Jacquard et Des Près city: Nancy country: France name: Coraline HINGRAY role: CONTACT email: coraline.hingray@cpn-laxou.com name: Coraline HINGRAY role: PRINCIPAL_INVESTIGATOR name: Lori PETROCELLI role: SUB_INVESTIGATOR lat: 48.68439 lon: 6.18496 facility: CHRU Nancy - Neurology department city: Nancy country: France name: Coraline HINGRAY role: CONTACT email: coraline.hingray@cpn-laxou.com name: Coraline HINGRAY role: PRINCIPAL_INVESTIGATOR name: Alexis TARRADA role: SUB_INVESTIGATOR name: Séverine CONRADI role: SUB_INVESTIGATOR name: Lori PETROCELLI role: SUB_INVESTIGATOR lat: 48.68439 lon: 6.18496 hasResults: False
nctId: NCT06330441 id: MOU-2021-01 briefTitle: Pancreatic Cancer Screening in a Population at High Risk acronym: ScrePan overallStatus: RECRUITING date: 2022-01-07 date: 2025-01-06 date: 2028-01-06 date: 2024-03-26 date: 2024-04-01 name: Masaryk Memorial Cancer Institute class: OTHER name: Masaryk University briefSummary: Pancreatic cancer is one of the diseases with the worst prognosis, which is mainly due to the initial asymptomatic prognosis. Unfortunately, the incidence of this disease in the Czech Republic is still increasing. In a certain proportion of patients, it is possible to predict the disease, e.g. due to family burdens. Regular follow-up of such individuals is the subject of the SCREPAN study: "Pancreatic Cancer Screening in High-Risk Persons". conditions: Pancreatic Ductal Adenocarcinoma conditions: Hereditary Diseases conditions: Pancreatitis, Chronic studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: SINGLE whoMasked: PARTICIPANT count: 700 type: ESTIMATED name: endoscopic ultrasonography name: magnetic resonance name: laboratory examination measure: Number of participants with newly diagnosed pancreatic ductal adenocarcinoma measure: Methods yield comparison measure: Screening methods cost-effectiveness measure: KRAS mutation status evaluation sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Masaryk Memorial Cancer Institute status: RECRUITING city: Brno zip: 65653 country: Czechia name: Martina Lojova, Ph.D. role: CONTACT phone: +420543136232 email: martina.lojova@mou.cz name: Dita Kozakova, Ing. role: CONTACT phone: +420543136236 email: dita.kozakova@mou.cz name: Petr Karasek, MD role: PRINCIPAL_INVESTIGATOR name: Jana Halamkova, MD role: SUB_INVESTIGATOR name: Helena Coupkova, MD role: SUB_INVESTIGATOR name: Anna Ondrackova, MD role: SUB_INVESTIGATOR name: Marketa Palacova, MD role: SUB_INVESTIGATOR name: Radim Nemecek, MD role: SUB_INVESTIGATOR name: Lumir Kunovsky, MD role: SUB_INVESTIGATOR name: Jan Trna, MD role: SUB_INVESTIGATOR name: Lenka Foretova, MD role: SUB_INVESTIGATOR name: Zdenka Cermakova, MD role: SUB_INVESTIGATOR name: Jan Kristek, MD role: SUB_INVESTIGATOR name: Roman Hrstka, Ph.D. role: SUB_INVESTIGATOR lat: 49.19522 lon: 16.60796 hasResults: False
nctId: NCT06330428 id: MU-Ebe-ZDKY-02 briefTitle: Investigation of the Effect of Sexuality-Based Family Planning Education Given to Women Via Podcast on Contraceptive Method Selection and Sexual Life Quality overallStatus: RECRUITING date: 2024-02-09 date: 2024-06-10 date: 2024-08-10 date: 2024-03-26 date: 2024-03-26 name: Marmara University class: OTHER briefSummary: In this study, it was aimed to examine the effect of Sexuality-Based Family Planning Education given to women of childbearing age via Podcast on contraceptive method selection and sexual life quality.
H4: Sexuality-based family planning education via podcast has a positive effect on women's attitudes towards family planning. conditions: Contraception studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: One control group, one experimental group primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: The experimental group will receive sexuality-based family planning education via podcast and outcome assessment will be performed by an investigator who was blinded to group assignment. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 176 type: ESTIMATED name: Sexuality-Based Family Planning Education via Podcast measure: Contraceptive Knowledge Assessment Scale-Turkish Form measure: Sexual Quality of Life Scale-Female measure: Family Planning Attitudes Scale sex: FEMALE minimumAge: 15 Years maximumAge: 49 Years stdAges: CHILD stdAges: ADULT facility: Marmara University status: RECRUITING city: Istanbul country: Turkey name: Meltem Demirgöz Bal role: CONTACT phone: +905056482983 email: meltemdemirgoz@gmail.com lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06330415 id: 25603 briefTitle: Effect and Process Evaluation of the SME Tool overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-08-01 date: 2024-03-26 date: 2024-03-26 name: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) class: OTHER name: ZonMw: The Netherlands Organisation for Health Research and Development briefSummary: A web-based tool has been developed to help small and medium-sized businesses support employees returning to work after sick-leave. A six-month trial is conducted, randomly assigning employer-employee dyads to either use the tool or receive standard care. The primary aim is to evaluate its impact on employee satisfaction with return-to-work support. conditions: Sick-listed Employees studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 404 type: ESTIMATED name: The SME tool measure: Satisfaction with the RTW support of employer assessed by the employee measure: Social support measure: Total number of sick-leave days measure: Work performance measure: Quality of working Life measure: Self-efficacy measure: Satisfaction with the resumption of work of the respective employee measure: Recruitment measure: Use of the SME tool measure: Perceived usefulness of the SME tool measure: Components of the logic model of change measure: Experiences sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06330402 id: N-20220063 briefTitle: Exploration of Gait Biomechanics and Pain overallStatus: RECRUITING date: 2023-09-26 date: 2026-12-31 date: 2026-12-31 date: 2024-03-26 date: 2024-03-26 name: Kristian Kjær Petersen class: OTHER briefSummary: This interventional study aims to test gait biomechanics in healthy individuals with and without experimental knee pain. The main questions it aims to answer are:
Participants will receive two knee injections: a) Hypertonic saline (painful condition) and b) Isotonic saline (control condition). conditions: Pain conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 34 type: ESTIMATED name: Hypertonic saline injection name: Isotonic saline injection measure: Infrared marker XYZ coordinates measure: Pain sensitivity. measure: The Pittsburgh Sleep Quality Index score measure: The Pain catastrophizing Scale score measure: The Hospital Anxiety and Depression Scale measure: Knee symptoms measure: Ground reaction forces measure: Ground reaction moments measure: Ground contact XZ location measure: Muscle activation measure: Pain intensity (NRS 0-10) measure: Pain distribution sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Aalborg University status: RECRUITING city: Aalborg state: Nordjylland zip: 9000 country: Denmark name: Kristian K Petersen, Dr. Med role: CONTACT phone: (+45) 31697510 email: kkp@hst.aau.dk name: Emma Hertel, M. Sc. role: CONTACT phone: (+45) 60887473 email: eh@hst.aau.dk lat: 57.048 lon: 9.9187 hasResults: False
nctId: NCT06330389 id: MRC-01-20-1074 briefTitle: Burn Injuries During COVID-19 Pandemic and Its Influence on Length of Stay overallStatus: COMPLETED date: 2020-04-01 date: 2021-03-01 date: 2021-06-25 date: 2024-03-26 date: 2024-03-26 name: Hamad Medical Corporation class: INDUSTRY briefSummary: Burn injuries were thought to be difficult to treat during the new corona virus epidemic. Our goal is to determine the risk factors that influence length of hospital stay (LOS) of burn injured patients during COVID -19 pandemic. conditions: SARS-CoV-2 Infection studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 70 type: ACTUAL name: Burn Injuries Graft Surgery measure: Our goal is to determine the risk factors that influence length of hospital stay (LOS) of burn injured patients during COVID -19 pandemic. measure: Clinical diffreneces between burn injuries with positive vs negative COVID-19 status sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: HAMAD Medical Corporation- Al Wakra Hospital city: Doha zip: 82228 country: Qatar lat: 25.28545 lon: 51.53096 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2020-05-30 uploadDate: 2021-09-07T14:07 filename: Prot_SAP_000.pdf size: 273860 hasResults: False
nctId: NCT06330376 id: PT-2022-30735 briefTitle: Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) overallStatus: RECRUITING date: 2024-03-01 date: 2024-06-01 date: 2024-09-01 date: 2024-03-26 date: 2024-04-05 name: University of Minnesota class: OTHER briefSummary: Diaphragm is the principal muscle of inspiration. Diaphragmatic dysfunction is seen in many conditions including following intubation, lung disease, prolonged ventilation, neuromuscular disease, phrenic nerve injury. The possible mechanisms of diaphragmatic dysfunction in patients with COVID19 are critical illness myopathy, ventilator-induced diaphragm dysfunction, iatrogenic phrenic nerve injury particularly secondary to line placement, post-infectious inflammatory neuropathy of the phrenic nerve, or possibly direct neuromuscular involvement of the SARS- CoV-2 virus given expression of the angiotensin- converting enzyme 2 (ACE2) receptor in the peripheral nervous system and skeletal muscle. The use of diaphragmatic ultrasound has been widely used to assess diaphragmatic function is well known in patients following prolonged mechanical ventilation. Prolonged mechanical ventilation leads to contractile dysfunction of respiratory muscles, in particular the diaphragm, causing a so-called ventilator-induced diaphragm dysfunction. The latter is defined as a loss of diaphragm force-generating capacity specifically related to the use of mechanical ventilation. However, the use of diaphragmatic Ultrasound to assess its function in Long COVID patients has not been noted and is a gap in the work up of these patients.
The purpose of this study is to address Diaphragmatic Dysfunctional (DD) breathing seen in patients with Post-Acute Sequelae of COVID-19 (PASC), which results in shortness of breath/chest tightness and subsequent fatigue. Targeting shortness of breath and subsequent fatigue as a central symptom of PASC will alleviate long term sequelae for the patients with PASC. DD will be addressed by a unique intervention of physical therapy. The goal of this prospective randomized clinical study will be to evaluate the comparative treatment effect of DB on markers, specifically fatigue, dyspnea, 6 min walk test, depression/anxiety, and quality of life (QoL). conditions: Post-Acute Sequelae of COVID-19 studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: prospective randomized clinical study with 2 arms primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: Usual care of traditional treatment name: Specific DB program/Diaphragmatic manipulation program measure: 6-minute walk test (6MWT) measure: PHQ9: Patient health questionnaire 9 measure: GAD7: Generalized anxiety disorder 7-item measure: PROMIS score: Patient-Reported Outcomes Measurement Information System measure: QoL scale: Quality of life scale measure: FACIT fatigue scale 's Fatigue score measure: Modified Borg dyspnea scale measure: RR; respiratory rate with 6 min walk test measure: PR: pulse rate with 6 min walk test sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Minnesota status: RECRUITING city: Minneapolis state: Minnesota zip: 55414 country: United States name: Farah Ikramuddin role: CONTACT email: ikram002@umn.edu lat: 44.97997 lon: -93.26384 hasResults: False
nctId: NCT06330363 id: METC 23-049 briefTitle: The Impact of Low Level Laser Treatment on Skeletal Muscle and Skin Tissue acronym: LASER overallStatus: RECRUITING date: 2024-04-01 date: 2024-08-31 date: 2024-12-31 date: 2024-03-26 date: 2024-04-17 name: Maastricht University Medical Center class: OTHER briefSummary: Rationale: Low level laser therapy, or photobiomodulation, is getting more attention as a non-invasive treatment strategy for numerous conditions. Phototherapy has been applied for more than 40 years for the treatment of musculoskeletal and neurological conditions. Low level laser therapy generally applies red or near-infrared lasers with a wavelength between 600 and 1000 nm and low power wattage from 5 to 500 mW and a power density between 1 and 5 W/cm2. The laser light is absorbed by the skin without thermal damage and penetrates deeply into tissues where it is supposed to induce its physiological effects at the cellular level. Laser therapy has been hypothesized to stimulate mitochondrial respiration, increase tissue oxygenation, and support tissue regeneration. Despite supportive research data on in vitro cell and in vivo animal data, there are surprisingly few data on the proposed impact of low level laser treatment (LLLT) on tissue metabolism in vivo in humans.
Main study parameters/endpoints: The primary outcome will be mitochondrial respiration of the LLLT treated and non-treated leg based on muscle samples. Secondary study parameters are muscle and skin gene expression, protein signalling and enzyme activity. conditions: Muscles Metabolism conditions: Skin Metabolism studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Within-subject study primaryPurpose: BASIC_SCIENCE masking: DOUBLE maskingDescription: One let will receive the laser therapy, the other one will get a sham laser. The person analyzing the samples will be blinded to legs. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 16 type: ESTIMATED name: Laser therapy name: Sham measure: Muscle mitochondrial respiration measure: Gene expression (mRNA) via real-time PCR measure: Protein expression via western blotting measure: Skin mitochondrial respiration sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Maastricht University Medical Centre status: RECRUITING city: Maastricht country: Netherlands name: Luc JC van Loon, PhD role: CONTACT phone: +31-43-3881397 email: l.vanloon@maastrichtuniversity.nl lat: 50.84833 lon: 5.68889 hasResults: False
nctId: NCT06330350 id: METC 2023-0193 briefTitle: Qualitative Study in Patients With Genodermatoses and Healthcare Professionals on Reproductive Counselling overallStatus: RECRUITING date: 2024-01-01 date: 2025-08-31 date: 2025-12-31 date: 2024-03-26 date: 2024-03-26 name: Maastricht University Medical Center class: OTHER briefSummary: The goal of this observational study is to understand the perspectives and needs of patients with genodermatoses and their partners who wish to have children, regarding their decision-making process and their consideration of reproductive options. Additionally, the investigators aim to investigate the level of knowledge and perspectives of healthcare professionals (such as clinical geneticists, dermatologists and other clinicians involved), and want to explore to what extent patients and their partners are well informed about these reproductive options. To achieve this, the investigators will conduct individual semi-structured qualitative interviews with participants affected by genodermatoses (and their partners) and with healthcare professionals. conditions: Quality of Life conditions: Ichthyosis conditions: Palmoplantar Keratoses conditions: Epidermolysis Bullosa conditions: Ectodermal Dysplasia conditions: Basal Cell Nevus Syndrome conditions: Birt-Hogg-Dube Syndrome conditions: Tuberous Sclerosis conditions: Cutis Laxa conditions: Albinism studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 25 type: ESTIMATED name: Qualitative interview measure: Assessment of perspectives of affected patients + partners and of healthcare professionals concerning reproductive decision-making sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Maastricht University Medical Center status: RECRUITING city: Maastricht state: Limburg zip: 6202 AZ country: Netherlands name: Fauve C van Veen role: CONTACT phone: +31433877293 email: genodermatose@mumc.nl lat: 50.84833 lon: 5.68889 hasResults: False
nctId: NCT06330337 id: ZSLL-KY-2024-010-01 briefTitle: Effect of Electroacupuncture Combined With Paclitaxel Clinical Efficacy of Patients With Recurrence of High-grade Glioma overallStatus: RECRUITING date: 2024-04-01 date: 2026-12-31 date: 2027-12-31 date: 2024-03-26 date: 2024-03-26 name: The Third Affiliated hospital of Zhejiang Chinese Medical University class: OTHER name: Zhejiang University briefSummary: Gliomas are the most common type of primary brain tumors, with surgery followed by radiotherapy and chemotherapy as the main treatment modalities. However, they are highly prone to recurrence, presenting significant treatment challenges, especially for high-grade gliomas, which have a 5-year survival rate of only 5.5%. Paclitaxel, a common chemotherapeutic agent, exhibits antitumor effects in vitro that are 1400 times stronger than those of temozolomide (the first-line chemotherapy drug for gliomas). However, due to its large molecular weight (approximately 893 Da), it cannot cross the blood-brain barrier, precluding its use as a first-line treatment for gliomas. Preliminary research by our team has demonstrated that Specific Mode Electroacupuncture Stimulation (SMES) can open the blood-brain barrier, enhancing the concentration of albumin-bound paclitaxel (ABX) in tumor tissues, peritumoral tissues, and surrounding invasive tissues, thereby exerting antitumor effects. Consequently, this study aims to observe the safety and efficacy of SMES combined with ABX in treating patients with recurrent high-grade gliomas postoperatively, to explore its mechanisms of action, extend survival, improve quality of life, and forge new theories and methods for the integrative treatment of brain tumors combining traditional Chinese and Western medicine. conditions: Glioma studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 58 type: ESTIMATED name: Temozolomide（TMZ） injection or oral administration name: Albumin-Bound Paclitaxel(ABX) intravenous drip name: Specific mode electroacupuncture stimulation(SMES) intervention measure: Overall survival（OS） measure: Progression-Free Survival (PFS) measure: Head MRI (plain and enhanced) measure: he Karnofsky Performance Score (KPS) measure: The Eastern Cooperative Oncology Group (ECOG) measure: The Quality of Life (QOL) measure: The Neurological Assessment for Neuro-Oncology (NANO) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Third Affiliated Hospital of Zhejiang Chinese Medical University status: RECRUITING city: Zhejiang country: China name: Xianming Lin, PHD role: CONTACT phone: +86-13858028101 email: linxianming1966@163.com name: Zhaoxing Jia, PHD role: CONTACT phone: +86-18356130598 email: zhenxinzhenyi183@163.com hasResults: False
nctId: NCT06330324 id: METC 2023-0182 briefTitle: Reproductive Options in Inherited Skin Diseases acronym: REPRO-ISD overallStatus: ENROLLING_BY_INVITATION date: 2024-01-01 date: 2026-09-01 date: 2026-09-01 date: 2024-03-26 date: 2024-03-26 name: Maastricht University Medical Center class: OTHER briefSummary: The goal of this observational study is to learn about the indications for prenatal diagnostics and preimplantation genetic testing for patients/couples affected by an inherited skin disease, and evaluate the clinical outcomes of these reproductive options. By providing a complete overview, the investigators aim to improve reproductive counselling for these patients/couples with a desire to have children.
To achieve this, the investigators aim to retrospectively collect data from a cohort of patiens/couples affected by an inherited skin disease on a national level (in the Netherlands) and also an international level from various countries in Europe. conditions: Ichthyosis conditions: Palmoplantar Keratoses conditions: Epidermolysis Bullosa conditions: Ectodermal Dysplasia conditions: Basal Cell Nevus Syndrome conditions: Birt-Hogg-Dube Syndrome conditions: Tuberous Sclerosis conditions: Xeroderma Pigmentosum conditions: Cutis Laxa conditions: Albinism studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 650 type: ESTIMATED measure: Assessment of clinical outcomes of reproductive options sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Maastricht University Medical Center city: Maastricht state: Limburg zip: 6202AZ country: Netherlands lat: 50.84833 lon: 5.68889 hasResults: False