nctId: NCT06322290 id: SEMBAI briefTitle: Epidemiological Study on Invasive Bacterial Diseases overallStatus: RECRUITING date: 2021-12-09 date: 2031-12-30 date: 2032-03-30 date: 2024-03-21 date: 2024-03-21 name: Meyer Children's Hospital IRCCS class: OTHER briefSummary: Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus), and Haemophilus influenzae (hemophilus) are among the main bacteria responsible for invasive bacterial diseases (MBIs) that result in severe clinical pictures also characterized by a high frequency of serious complications. Surveillance of infections caused by these pathogens and their distribution by serotypes/serogroups is essential to guide public health interventions, assess epidemiologic trends, monitor any secondary cases, estimate the proportion of preventable cases, identify any vaccine failures, and evaluate the impact of vaccine strategies.The present study aims to study the epidemiology of invasive bacterial diseases, characterize the circulating strains also in order to plan treatment and prevention strategies. conditions: Invasive Bacterial Diseases (IBD) studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 5000 type: ESTIMATED name: assessment of pathogens in blood specimens measure: Incidence rate of Infective Bacterial Diseases from Streptococcus pneumoniae (pneumococcus) during the study period in pediatric age. measure: Incidence rate of of Infective Bacterial Diseases cases from Neisseria meningitidis during the study period in pediatric age. measure: Incidence rate of Infective Bacterial Diseases cases from Haemophilus influenzae during the study period in pediatric age. measure: Frequency of circulating serogroups/serotypes in Italy for S.pneumoniae, N.meningitidis, H.influenzae. measure: Proportion of these invasive infections (S.pneumoniae, N.meningitidis, H.influenzae) that are preventable by vaccine in Italy measure: Vaccine failure rate for S.pneumoniae, N.meningitidis, and H.influenzae. sex: ALL minimumAge: 1 Day maximumAge: 70 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Ospedale di Adria status: NOT_YET_RECRUITING city: Adria country: Italy lat: 45.05445 lon: 12.05599 facility: Ospedali riuniti di Ancona status: NOT_YET_RECRUITING city: Ancona country: Italy lat: 43.5942 lon: 13.50337 facility: Ospedale di Andria status: NOT_YET_RECRUITING city: Andria country: Italy lat: 41.23117 lon: 16.29797 facility: Ospedale Giovanni XXIII status: NOT_YET_RECRUITING city: Bari country: Italy lat: 41.11148 lon: 16.8554 facility: Policlinico S.Orsola-Malpighi IRCCS status: NOT_YET_RECRUITING city: Bologna country: Italy lat: 44.49381 lon: 11.33875 facility: Fondazione poliambulanza Brescia status: NOT_YET_RECRUITING city: Brescia country: Italy lat: 45.53558 lon: 10.21472 facility: Ospedale Giovanni XXIII status: NOT_YET_RECRUITING city: Brescia country: Italy lat: 45.53558 lon: 10.21472 facility: Ospedale di Campobasso status: NOT_YET_RECRUITING city: Campobasso country: Italy lat: 41.55947 lon: 14.66737 facility: Ospedale Camposampiero status: NOT_YET_RECRUITING city: Camposampiero country: Italy lat: 45.56368 lon: 11.93534 facility: Ospedale di Esine asst Valcamonica status: NOT_YET_RECRUITING city: Esine country: Italy lat: 45.92515 lon: 10.25102 facility: Ospedale di Feltre (AULSS 1 Dolomiti) status: NOT_YET_RECRUITING city: Feltre country: Italy lat: 46.02085 lon: 11.90031 facility: Immunology Laboratory Meyer Children's Hospital IRCCS status: RECRUITING city: Florence country: Italy name: Chiara Azzari, MD role: CONTACT phone: 00390555662542 lat: 43.77925 lon: 11.24626 facility: Ospedale Morgagni status: NOT_YET_RECRUITING city: Forlì country: Italy lat: 44.22177 lon: 12.04144 facility: AO Salvini di Garbagnate status: NOT_YET_RECRUITING city: Garbagnate country: Italy lat: 45.77027 lon: 9.29848 facility: Azienda sanitaria universitaria Giuliano Isontina (ASU GI) status: NOT_YET_RECRUITING city: Gorizia country: Italy lat: 45.94088 lon: 13.62167 facility: Ospedale di Macerata status: NOT_YET_RECRUITING city: Macerata country: Italy lat: 43.29789 lon: 13.45293 facility: Ospedale di Magenta status: NOT_YET_RECRUITING city: Magenta country: Italy lat: 45.46456 lon: 8.88453 facility: Azienda Ospedaliera Policlinico Universitario "G. Martino" status: NOT_YET_RECRUITING city: Messina country: Italy lat: 38.19394 lon: 15.55256 facility: IRCCS San Raffaele status: NOT_YET_RECRUITING city: Milano country: Italy lat: 45.46427 lon: 9.18951 facility: AORN Santobono status: NOT_YET_RECRUITING city: Napoli country: Italy lat: 40.85216 lon: 14.26811 facility: AOU Federico II di Napoli status: NOT_YET_RECRUITING city: Napoli country: Italy lat: 40.85216 lon: 14.26811 facility: Ospedale di Novara status: NOT_YET_RECRUITING city: Novara country: Italy lat: 45.44694 lon: 8.62118 facility: Fondazione I.R.C.C.S. Policlinico San Matteo status: NOT_YET_RECRUITING city: Pavia country: Italy lat: 45.19205 lon: 9.15917 facility: Ospedale spirito santo di Pescara status: NOT_YET_RECRUITING city: Pescara country: Italy lat: 42.4584 lon: 14.20283 facility: Azienda sanitaria Friuli occidentale status: NOT_YET_RECRUITING city: Pordenone country: Italy lat: 45.95689 lon: 12.66051 facility: Ospedale degli infermi status: NOT_YET_RECRUITING city: Rimini country: Italy lat: 44.05755 lon: 12.56528 facility: Ospedale Pediatrico Bambin Gesù IRCCS status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Ospedale Sandro Pertini status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Ospedale San Leonardo di Salerno status: NOT_YET_RECRUITING city: Salerno country: Italy lat: 40.67545 lon: 14.79328 facility: Ospedale di Saronno status: NOT_YET_RECRUITING city: Saronno country: Italy lat: 45.62513 lon: 9.03517 facility: AOU Sassari status: NOT_YET_RECRUITING city: Sassari country: Italy lat: 40.72586 lon: 8.55552 facility: Ospedale di Scorrano status: NOT_YET_RECRUITING city: Scorrano country: Italy lat: 40.09018 lon: 18.29993 facility: ASP Trapani status: NOT_YET_RECRUITING city: Trapani country: Italy lat: 38.0176 lon: 12.53617 facility: IRCCS Materno Infantile Burlo Garofolo status: NOT_YET_RECRUITING city: Trieste country: Italy lat: 45.64953 lon: 13.77679 facility: Azienda sanitaria universitaria Friuli Centrale (ASU FC) status: NOT_YET_RECRUITING city: Udine country: Italy lat: 46.0693 lon: 13.23715 facility: Azienda ospedaliera universitaria integrata Verona status: NOT_YET_RECRUITING city: Verona country: Italy lat: 45.4299 lon: 10.98444 facility: Ospedale civile di Vibo Valentia status: NOT_YET_RECRUITING city: Vibo Valentia country: Italy lat: 38.67618 lon: 16.10094 facility: Ospedale Maggiore Carlo Alberto Pizzardi status: NOT_YET_RECRUITING city: Bologna state: Ì country: Italy lat: 44.49381 lon: 11.33875 hasResults: False