hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06269393 id: CIBI311Y101 briefTitle: A Study of IBI311 in Subjects With Steroid-resistant, Thyroid Associated Ophthalmopathy overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-01 date: 2025-06-01 date: 2026-02-01 date: 2024-02-21 date: 2024-02-21 name: Peking University People's Hospital class: OTHER briefSummary: This is an exploratory study of the efficacy and safety of IBI311, a modified anti-IGF-1R antibody, in patients with steroid-resistant, thyroid associated ophthalmopathy (TAO). This study includes two stages. Stage I is a single-center, single-arm, open-label clinical study designed to evaluate the safety and tolerability of IBI311 in subjects with TAO. Approximately 10 subjects meeting the study eligibility criteria will be enrolled. Stage II is a single-center, randomized, double-masked, placebo-controlled clinical trial designed to evaluate the efficacy and safety of IBI311 in subjects with steroid-resistant TAO. Approximately 54 subjects meeting the study eligibility criteria will be randomly assigned to IBI311 or placebo on day 1 (D1) in a 2:1 ratio stratified by disease activity. conditions: Thyroid Associated Ophthalmopathy studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 54 type: ESTIMATED name: Placebo name: IBI311 measure: The proptosis responder rate (defined as percentage of subjects with a ≥ 2mm reduction from baseline in proptosis in the study eye, without deterioration [≥ 2 mm increase] of proptosis in the non-study eye) of the study eye. measure: Overall responder rate in proptosis of the study eye. measure: Percentage of subjects with a CAS value of 0 or 1 measure: Diplopia responder rate (defined as percentage of subjects with a ≥ 1-grade improvement in diplopia) measure: Safety and tolerability of intravenous IBI311 in subjects with TAO sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking University People's Hospital city: Beijing state: Beijing zip: 100034 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06269380 id: 30.01.2024-4274 briefTitle: Evaluation of Antral Biopsies Obtained in Normal Esophagogastroduodenoscopy overallStatus: COMPLETED date: 2024-02-13 date: 2024-02-20 date: 2024-02-21 date: 2024-02-21 date: 2024-02-23 name: Sisli Hamidiye Etfal Training and Research Hospital class: OTHER briefSummary: Esophagogastroduodenoscopy (EGD) is commonly performed in patients presenting with abdominal pain and dyspeptic symptoms, serving as a valuable diagnostic and therapeutic tool. While various methods are available for biopsy sampling when mucosal pathology is observed during EGD, the practice of obtaining biopsies from endoscopically normal mucosa remains controversial. Although there is literature suggesting that routine biopsies from the antrum and duodenum for surveillance purposes increase costs, pathological findings can sometimes be detected in areas that appear normal on mucosal examination, leading to potential changes in treatment approach if biopsies are obtained.
In this study, a retrospective evaluation of the prevalence of various pathologies detected in biopsies obtained from endoscopically normal mucosa in patients who underwent EGD was reported as normal. conditions: Gastritis H Pylori conditions: Gastritis Chronic conditions: Intestinal Metaplasia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: The biopsies obtained from patients who underwent esophagogastroduodenoscopy and were found to have normal endoscopic findings will be evaluated. The histopathological findings and their frequencies in these biopsies will be examined to assess the necessity of routine biopsy during esophagogastroduodenoscopy. primaryPurpose: DIAGNOSTIC masking: NONE count: 671 type: ACTUAL name: Esophagogastroduodenoscopy name: Endoscopic biopsy sampling measure: Rate of abnormal histopathologic findings measure: Rate of intestinal metaplasia measure: Rates of gastritis severity and activity measure: Rate of Helicobacter Pylori positivity sex: ALL minimumAge: 18 Years maximumAge: 95 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sisli Hamidiye Etfal Research and Training Hospital city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06269367 id: HUM00226149 id: 1R41HD111289-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R41HD111289-01 briefTitle: NewGait: A Low-Cost Rehabilitation System to Improve Post-Stroke Gait (Biomechanical Adaptations) overallStatus: RECRUITING date: 2024-04-01 date: 2024-12 date: 2024-12 date: 2024-02-21 date: 2024-04-03 name: University of Michigan class: OTHER name: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) briefSummary: An affordable and easy to use gait-assistive device for stroke survivors to use at home is yet to be developed. This study is intended to modify the current design of the NewGait device to specifically work for stroke survivors based on feedback from patients and clinicians. Consequently, conducting a short-term biomechanical gait study is planned to determine the usability and functionality of the NewGait device compared to other comparative devices. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Participants will be randomly assigned to the two device interventions but will receive both interventions. primaryPurpose: TREATMENT masking: NONE count: 18 type: ESTIMATED name: NewGait name: Control wearable limb orthotic device measure: Gait speed measure: Ankle Muscle Activation measure: Changes in paretic leg propulsive force measure: Changes in paretic leg loading (i.e., vertical ground reaction force) measure: Changes in other lower extremity muscle activation measure: Muscle Coordination sex: ALL minimumAge: 40 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Physical Medicine & Rehabilitation 325 E Eisenhower Pkwy Suite 3011 status: RECRUITING city: Ann Arbor state: Michigan zip: 48108 country: United States name: Chanramouli Krishnan, PT, PhD role: CONTACT phone: 734-936-4031 email: mouli@umich.edu lat: 42.27756 lon: -83.74088 hasResults: False
nctId: NCT06269354 id: 20231121-71479 briefTitle: Multi-center Study on Comprehensive Diagnosis and Treatment of Lower Limb Bone Defect Based on Three-dimensional Printing Technology overallStatus: RECRUITING date: 2023-11-01 date: 2026-06-01 date: 2026-12-31 date: 2024-02-21 date: 2024-02-21 name: Peking University Third Hospital class: OTHER briefSummary: The clinical diagnosis and treatment of lower limb bone defect is a difficult problem in orthopedics. The traditional treatment has the shortcomings of long treatment period, no weight bearing in the early stage of the limb, weak mechanical strength, many complications, and difficulty in repairing deformed and large segment bone defects around the joint. The Orthopedics Department of Peking University Third Hospital, the lead unit of this study, developed the TCBridge system based on three-dimensional (3D) printing technology in the early stage, which is the first approved 3D printing lower limb long bone defect repair system in China. The system can achieve personalized and accurate repair of lower limb bone defects, and ensure patients to carry out limb weight and functional exercise safely in the early stage after surgery. On this basis, this study will establish a multi-center clinical case cohort to achieve accurate comprehensive diagnosis and treatment of lower limb bone defects, benefiting patients and contributing to society. conditions: Bone Defects studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 120 type: ESTIMATED name: 3D printed prostheses measure: Evaluation of implant stability, new bone growth- limb length measure: Evaluation of bone healing measure: Pain assessment measure: Evaluation of life quality and health status. measure: Evaluation of knee function measure: Evaluation of hip function measure: Evaluation of ankle function sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking University Third Hospital status: RECRUITING city: Beijing state: Haidian country: China name: Bingchuan Liu role: CONTACT phone: +86 18310188678 email: liubc@bjmu.edu.cn lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06269341 id: SCCH-TS2208 briefTitle: Outcomes of Smoker and Drinker With Esophageal Squamous Cell Carcinoma After Esophagectomy acronym: OSinEC overallStatus: RECRUITING date: 2010-02-01 date: 2024-07-30 date: 2024-08-30 date: 2024-02-21 date: 2024-02-21 name: Sichuan Cancer Hospital and Research Institute class: OTHER briefSummary: Our study demonstrates that patients who did not consume alcohol or smoke had a significant advantage in overall survival (OS) after undergoing esophagectomy. Furthermore, our findings indicate that there was no statistically significant difference in OS between patients with a history of both smoking and drinking, and those who only smoked or drank conditions: Outcomes of Smoker and Drinker After Esophagectomy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 2957 type: ESTIMATED name: No intervention measure: Overall Survival sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sichuan Cancer Hospital and Research Institute status: RECRUITING city: Chengdu state: Sichuan zip: 610041 country: China name: Lin Peng, M.D. role: CONTACT phone: +8618908190013 email: penglinms@126.com name: Wenwu He, M.D. role: CONTACT phone: +8613350055340 email: wenwu_he@126.com lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06269328 id: 2011-KAEK-26/463 briefTitle: Measuring Sleep Quality In Patients That Posterior Spinal Instrumentatıon Plannıng overallStatus: COMPLETED date: 2022-07-01 date: 2023-09-01 date: 2024-01-01 date: 2024-02-21 date: 2024-02-28 name: Uludag University class: OTHER briefSummary: Postoperative sleep disorders have serious problems with cognition, pain perception, sustained circadian rhythm, psychomotor function, metabolic function, catabolic responses, and continuity. The relationship between general anesthesia and sleep disturbances following surgery is still unclear. Since the risk of sleep disorders after surgery is high, it is important to determine the efficiency of the interval with automatic sleep disorders. By evaluating how major orthopedic surgery and general anesthesia applied to posterior spinal instrumentation divides sleep quality, risk management allows determining the factors involved in the peroperative period and thus facilitating surgical results and patient comfort. conditions: Sleep Disorder conditions: Sleep, Inadequate conditions: Total ıntravenous Anesthesia conditions: Inhalation Anesthesia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 39 type: ACTUAL name: Total ıntravenous anesthesia with propofol and remifentanil for anesthetic maintenance name: Inhalation anesthesia with sevoflurane for anesthetic maintenance measure: Subjective sleep quality (evaluated by PIRS-20 (Pitssburg Insomnia Rating Scale) measure: Subjective anxiety level measure: Subjective pain level sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Elifgül Ulutaş city: Bursa state: Nilüfer zip: 16240 country: Turkey lat: 40.19559 lon: 29.06013 hasResults: False
nctId: NCT06269315 id: SBDDCP briefTitle: Assessment of Skin Barrier Disruption Due to Daily Use of Cleaning Products and Hand Disinfectants acronym: SBDDCP overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2025-04-01 date: 2024-02-21 date: 2024-02-21 name: Swiss Institute of Allergy and Asthma Research class: OTHER name: University Hospital, Zürich briefSummary: The goal of this clinical trial is to assess the effects of household detergents and hand disinfectants on human skin barrier integrity among healthy adult volunteers.
Researchers will compare the effects of different types of cleaning agents, hand disinfectants, and their ingredients on skin barrier integrity to determine variations in their impact. conditions: Control Condition (PBS) conditions: Household Detergent Exposure conditions: Hand Disinfectant Exposure conditions: Surfactant Exposure conditions: Other Ingredients Exposure studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: 1. Skin Cleansing and Testing Patch Preparation:
The patch will be gently removed from the skin. Exposed areas of skin will be evaluated by EIS at specific times up to 24 hours after the treatment. primaryPurpose: BASIC_SCIENCE masking: NONE count: 50 type: ESTIMATED name: Cleaning product exposure measure: Skin barrier evaluation sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Swiss Institute of Allergy and Asthma Research city: Davos state: Graubuenden zip: 7265 country: Switzerland name: Yasutaka Mitamura, MD PhD role: CONTACT phone: +41 (0) 81 410 08 48 email: yasutaka.mitamura@siaf.uzh.ch name: Cezmi A Akdis, MD professor role: CONTACT phone: +41 (0) 81 410 08 48 email: cezmi.akdis@siaf.uzh.ch name: Manru Li role: SUB_INVESTIGATOR name: Marie-Charlotte Brueggen, MD PhD professor role: SUB_INVESTIGATOR lat: 46.80429 lon: 9.83723 hasResults: False
nctId: NCT06269302 id: 2 briefTitle: Comparison of the Effect of Warfarin and Direct Oral Anticoagulants overallStatus: COMPLETED date: 2022-01-01 date: 2022-12-31 date: 2022-12-31 date: 2024-02-21 date: 2024-02-21 name: Samsun Education and Research Hospital class: OTHER briefSummary: In this study, it was aimed to compare the frequency of new oral anticoagulants and warfarin usage, and to reveal the rates of recurrent upper gastrointestinal bleeding among patients who applied to our hospital with upper gastrointestinal bleeding conditions: Anticoagulants and Bleeding Disorders conditions: Gastrointestinal Hemorrhage studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 346 type: ACTUAL measure: Change in the incidence of recurrent bleeding sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Samsun Education and Research Hospital city: Samsun state: İlkadım country: Turkey lat: 41.27976 lon: 36.3361 hasResults: False
nctId: NCT06269289 id: SBU-KOMSERN-001 briefTitle: Effects of Web-Based Education on Patient Empowerment and Asthma Control in Asthma Patients overallStatus: NOT_YET_RECRUITING date: 2024-05-30 date: 2024-06-30 date: 2024-09-30 date: 2024-02-21 date: 2024-02-21 name: Saglik Bilimleri Universitesi class: OTHER briefSummary: Asthma is defined as a chronic inflammatory disorder of the airways associated with an extreme increase in airway hyperresponsiveness leading to recurrent wheezing, shortness of breath, chest tightness, and coughing attacks. The World Health Organization states that approximately 339 million individuals worldwide have asthma and more than 400 thousand deaths occur due to asthma every year.
With effective and sustainable asthma management, it is possible to reduce disease-related complaints, admissions to emergency units and hospitalizations, limit the physiological and psychological effects of the disease, prevent dependence on healthcare professionals and caregivers, increase the quality of life and reduce the mortality of the disease. Patient education, which is within the educational role of professional nurses, is very important in asthma management. The research was planned in a single-center, randomized control group pretest-posttest design. The sample will consist of individuals who applied to the Allergy and Immunology clinic of Sureyyapasa Chest Diseases and Surgery Training and Research Hospital between May 2024 and January 2024, who have been diagnosed with asthma for at least one year and who accept the study \[25 intervention group - 25 control group\]. Groups will be determined using the random numbers table from the simple random sampling method. A web-based asthma education module will be created in line with the literature, and participants in the intervention group will be given synchronous training in 5 modules. After meeting the individuals in the intervention and control groups and obtaining verbal and written consent, they will be asked to fill out the Patient Information Form, Patient Empowerment Scale and Asthma Control Test prepared via Google Forms. A 30-minute training session will be given to the intervention group every week and there will be short evaluations after each training. When the 5th Module is completed, the intervention group will be asked to fill out the Patient Empowerment Scale and Asthma Control Test Scale. No intervention will be applied to the control group. 5. At the end of the module, the Patient Empowerment Scale and Asthma Control Test will be completed by individuals in the control group. It is thought that web-based asthma education that individuals will receive will positively affect their empowerment levels and increase their disease control. conditions: Asthma conditions: Patient Empowerment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The research was designed as a randomized controlled experimental study with a pretest-posttest design. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 50 type: ESTIMATED name: web based education name: Standard education brochure measure: patient empowerment scale (PES) measure: Asthma Control Test (ACT) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital city: Istanbul zip: 34854 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06269276 id: CAVCU briefTitle: Caregiver Contribution to Self-Care in Ostomy Patient Index: Turkish Validity and Reliability Study overallStatus: COMPLETED date: 2020-09-20 date: 2021-01-15 date: 2021-01-15 date: 2024-02-21 date: 2024-02-21 name: Namik Kemal University class: OTHER briefSummary: This study was conducted to evaluate the Turkish validity and reliability of the Caregiver Contribution to Self-Care in Ostomy Patient Index, to evaluate the relatives of patients with stoma who contribute to their self-care in Turkish society, and to contribute to the nursing literature of the measurement tool.
This methodological type of research was carried out between September 2020 and January 2021 in a state and a university hospital in Tekirdağ. The research sample consisted of 223 individuals who contributed to the self-care of individuals with colostomy, ileostomy and urostomy who applied for outpatient control. In the analysis of the data, descriptive statistics, language and content validity, confirmatory factor analysis, item analysis, internal consistency and test-retest methods were used.
At the end of the study, it was determined that the scale was suitable for Turkish society and was valid and reliable in Turkish. conditions: Stoma Colostomy conditions: Stoma Ileostomy conditions: Caregiver conditions: Self Care studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 223 type: ACTUAL name: Caregiver Contribution to Self-Care in Ostomy Patient Index measure: Caregiver Contribution to Self-Care in Ostomy Patient Index sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tekirdag Namık Kemal University city: Tekirdag state: Suleymanpasa zip: 59000 country: Turkey lat: 40.9781 lon: 27.51101 hasResults: False
nctId: NCT06269263 id: 339/23-ek briefTitle: Pilot Study to Determine Feasibility of Home-based Cardiac Rehabilitation in Patients With Chronic Heart Failure (Pilot-CRHF) acronym: Pilot-CRHF overallStatus: NOT_YET_RECRUITING date: 2024-02-19 date: 2025-02 date: 2025-02 date: 2024-02-21 date: 2024-02-21 name: University of Leipzig class: OTHER briefSummary: The proposed study will determine the willingness of patients for participation. Furthermore, the assessment of tests to identify eligible patients and the type of exercise intervention that goes along with a high patient compliance is crucial. Also, more information about possible factors preventing patients from participating is required. Therefore, if the patient is willing to participate, we will assess patients' medical history, medication and QoL as well as parameters of routine diagnostics (i.e. echocardiography, laboratory testing, MRI). Following, while the in-patient stay due to cardiac decompensation, we will conduct several assessment-tests to determine the physical status, the exercise capacity and the cognitive function. Moreover, physiotherapists will instruct the patients in the exercise program. After discharge from the hospital, physiotherapist will visit the patient at home to instruct them again in the exercises. Then, the patients will conduct the program on their own for a period of 12 weeks. During the exercise period, a doctoral student will visit the patients at home every 3 weeks to check whether they are doing the exercises correctly and to determine whether there are any problems with the program. After the exercise period of 12 weeks, the baseline characteristics will be assessed again at the University Hospital Leipzig. conditions: Heart Failure studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Pilot study of home-based cardiac rehabilitation primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 30 type: ESTIMATED name: Home-based cardiac rehabilitation measure: Percentage of patients completing the program measure: Quality of life measure: Exercise capacity sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Universitätsklinikum Leipzig city: Leipzig state: Saxony zip: 04103 country: Germany lat: 51.33962 lon: 12.37129 hasResults: False
nctId: NCT06269250 id: ANDI-MFA2023_10 briefTitle: Acceptance and Perceived Benefits of Digitalization by Medical Assistants acronym: ANDI-MFA overallStatus: RECRUITING date: 2023-11-01 date: 2024-12-31 date: 2024-12-31 date: 2024-02-21 date: 2024-02-21 name: Jacobs University Bremen gGmbH class: OTHER name: Mirjam Jansen; medmedia Academy briefSummary: The aim of this project is to improve the integration of digital processes, including e-prescriptions, within medical and dental practices for healthcare professionals. Through a better understanding of the obstacles healthcare workers encounter during the adoption of digital processes and their feedback post-implementation, this study will add to the current state of science, contributing to digital process optimization in healthcare. conditions: Health Care Providers conditions: Patient Safety conditions: eHealth studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: Policy Change measure: Adoption and acceptance of information technology (IT) measure: Requests by patients regarding IT measure: Perceived Benefits of IT measure: Knowledge and Digital health literacy measure: Preferred learning format sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Germany status: RECRUITING city: Bremen zip: 28759 country: Germany name: Sonia Lippke, Prof. Dr. role: CONTACT phone: +49 421 200 4730 email: slippke@constructor.university name: Keller Franziska, PhD role: CONTACT phone: +49 421 200 4730 email: fkeller@constructor.university lat: 53.07516 lon: 8.80777 hasResults: False