nctId: NCT06263426 id: IRB00387066 id: U01AI177211 type: NIH link: https://reporter.nih.gov/quickSearch/U01AI177211 briefTitle: Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney) overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2028-09 date: 2029-09 date: 2024-02-16 date: 2024-02-16 name: Johns Hopkins University class: OTHER name: National Institute of Allergy and Infectious Diseases (NIAID) briefSummary: This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV. conditions: Hiv studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 200 type: ESTIMATED name: HIV D+/R+ name: HIV D-/R+ measure: Cumulative incidence of death and allograft rejection. measure: Participant survival measure: Graft survival measure: Type and severity of graft rejection measure: Time to first rejection measure: Rate of rejection events over time measure: Graft function over time measured by eGFR trajectory measure: Incidence of HIV viremia post-transplant measure: Incidence of new antiretroviral drug resistance and/or X4 tropic virus posttransplant measure: Incidence of bacterial, fungal, viral, and other opportunistic infections posttransplant measure: Incidence of surgical and vascular transplant complications post-transplant measure: Incidence and causes of chronic kidney disease post-transplant measure: Incidence of post-transplant malignancies measure: Incidence of de novo donor specific antibody (DSA) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Alabama at Birmingham city: Birmingham state: Alabama zip: 35294 country: United States name: Shikha Mehta, MD role: CONTACT email: smehta@uabmc.edu name: Shikha Mehta, MD role: PRINCIPAL_INVESTIGATOR lat: 33.52066 lon: -86.80249 facility: University of California, Los Angeles city: Los Angeles state: California zip: 90095 country: United States name: Joanna Schaenman, MD, PhD role: CONTACT email: JSchaenman@mednet.ucla.edu name: Joanna Schaenman, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 34.05223 lon: -118.24368 facility: University of California, San Diego city: San Diego state: California zip: 92037 country: United States name: Saima Aslam, MBBS role: CONTACT email: saslam@ucsd.edu name: Saima Aslam, MBBS role: PRINCIPAL_INVESTIGATOR lat: 32.71533 lon: -117.15726 facility: University of California, San Francisco city: San Francisco state: California zip: 94143 country: United States name: Garrett Roll, MD role: CONTACT email: Garrett.Roll@ucsf.edu name: Garrett Roll, MD role: PRINCIPAL_INVESTIGATOR lat: 37.77493 lon: -122.41942 facility: Yale School of Medicine city: New Haven state: Connecticut zip: 06510 country: United States name: Maricar Malinis, MD role: CONTACT email: maricar.malinis@yale.edu name: Maricar Malinis, MD role: PRINCIPAL_INVESTIGATOR lat: 41.30815 lon: -72.92816 facility: Rush University Medical Center city: Chicago state: Illinois zip: 60612 country: United States name: Carlos Santos, MD role: CONTACT email: Carlos_A_Santos@rush.edu name: Carlos Santos, MD role: PRINCIPAL_INVESTIGATOR lat: 41.85003 lon: -87.65005 facility: Ochsner Clinic Foundation city: New Orleans state: Louisiana zip: 70121 country: United States name: Jonathan Hand, MD role: CONTACT email: jonathan.hand@ochsner.org name: Jonathan Hand, MD role: PRINCIPAL_INVESTIGATOR lat: 29.95465 lon: -90.07507 facility: Johns Hopkins University city: Baltimore state: Maryland zip: 21205 country: United States name: Christine Durand, MD role: CONTACT email: cdurand2@jhmi.edu name: Christine Durand, MD role: PRINCIPAL_INVESTIGATOR lat: 39.29038 lon: -76.61219 facility: Massachusetts General Hospital city: Boston state: Massachusetts zip: 02114 country: United States name: Nahel Elias, MD role: CONTACT email: elias.nahel@mgh.harvard.edu name: Nahel Elias, MD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: New York University city: New York state: New York zip: 10016 country: United States name: Sapna Mehta, MD role: CONTACT email: Sapna.mehta@nyumc.org name: Sapna Mehta, MD role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 facility: Icahn School of Medicine at Mt. Sinai city: New York state: New York zip: 10029 country: United States name: Sander Florman, MD role: CONTACT email: Sander.florman@mountsinai.org name: Sander Florman, MD role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 facility: Columbia University city: New York state: New York zip: 10032 country: United States name: Marcus Pereira, MD role: CONTACT name: Marcus Pereira, MD role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 facility: Weill Cornell Medical Center city: New York state: New York zip: 10065 country: United States name: Catherine Small, MD role: CONTACT email: Cbs9003@med.cornell.edu name: Catherine Small, MD role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 facility: University of Pittsburgh Medical Center city: Pittsburgh state: Pennsylvania zip: 15213 country: United States name: Ghady Haidar, MD role: CONTACT email: haidarg@upmc.edu name: Ghady Haidar, MD role: PRINCIPAL_INVESTIGATOR lat: 40.44062 lon: -79.99589 hasResults: False