hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06387784 id: 2024/823 briefTitle: Acute Beetroot Juice Supplementation in Pre-eclampsia Pregnancies acronym: BEET_PE overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2024-12 date: 2025-06 date: 2024-04-29 date: 2024-04-29 name: University of Sao Paulo class: OTHER name: Hospital das Clínicas de Ribeirão Preto name: Universidade Estadual Paulista Júlio de Mesquita Filho briefSummary: Pre-eclampsia is a serious condition that typically affects pregnant women after the 20th week of pregnancy, characterized by high blood pressure and damage to organs such as the kidneys and liver. Currently, treatment options are limited, which has prompted researchers to explore alternative approaches. One such promising alternative is dietary nitrate found in vegetables like beetroot, as nitrate can be converted into nitric oxide in the body, which helps lower blood pressure. This study aims to determine the acute effects of nitrate-rich beetroot juice on blood pressure, several blood and salivary markers in pregnant women with pre-eclampsia. Furthermore, the study will assess fetal blood flow using Doppler ultrasound. The investigators want to understand the kinetics of nitrate and nitric oxide metabolites and assess the temporal dependency of the hypotensive response. Through this investigation, the investigators seek evidence of nitrate-enriched beetroot juice as an adjunct therapy in managing pre-eclampsia. conditions: Pre-Eclampsia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized, placebo-controlled, single-blind, parallel-group study assessing acute rich-nitrate juice on pregnant women diagnosed with early and late-onset pre-eclampsia. Participants will be divided into four distinct groups: two groups for each onset category. Within each group, participants will be further divided into a control group and a treated group. The assignment of participants to these groups will be randomized using an online program. primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 96 type: ESTIMATED name: Beetroot juice name: Placebo juice measure: Acute Effect of Beetroot Juice Supplementation on Blood Pressure measure: Plasma Concentrations of Nitric Oxide Metabolites measure: Concentration of Salivary Nitrate Reductase Enzyme measure: Plasma Lipid Peroxidation Levels measure: Concentration of Total Antioxidant Capacity in Plasma measure: Maternal Blood Flow Velocity measure: Fetal Heart Rate measure: Umbilical Arterial Pulsatility Index sex: FEMALE minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT hasResults: False
nctId: NCT06387771 id: rs4680-tolcapona briefTitle: Evaluation of Tolcapone as a Cognitive Enhancer in Schizophrenia overallStatus: RECRUITING date: 2014-09-22 date: 2025-08 date: 2024-04-29 date: 2024-04-29 name: Clinica Universidad de Navarra, Universidad de Navarra class: OTHER briefSummary: Objective: To assess the efficacy of tolcapone to improve cognition in schizophrenia, as a genotype-based targeted treatment of cognitive and negative symptoms of schizophrenia considering the polymorphism rs4680.
Methodology: 20 patients with chronic and stabilized schizophrenia (10 patients with genotype Val/Val and 10 patients with genotype Met/Met according to polymorphism rs4680) will receive treatment with tolcapone during 7 days. The cognitive function and clinical status will be evaluated with a neuropsychological battery and appropriate clinical scales before and after treatment. The efficiency of the activation of the prefrontal cortex will be measured using functional magnetic resonance imaging (fMRI) before and after treatment.
Hypothesis: Only patients with genotype Val/Val treated with tolcapone would show a cognitive improvement, a higher efficiency of the activation of the prefrontal cortex and an amelioration of some negative symptoms. conditions: Schizophrenia studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Tolcapone measure: Efficacy: Change from baseline in cognitive test scores at day 8 measure: Efficacy: Change from baseline in the brain blood-oxygen-level-dependent (BOLD) response at day 8 measure: Efficacy: change from baseline in psychotic symptoms intensity measured by the PANSS scores at day 8 measure: Efficacy: negative symptoms intensity: change from baseline in the 16-item Negative Symptom Assessment (NSA-16) scale scores at day 8 measure: Efficacy: change from baseline in the intensity of psychotic symptoms measured by the Brief Psychiatric Rating Scale (BPRS) scores at day 8 measure: Efficacy: change from baseline in the clinical global impression measured by the Clinical Global Impression (CGI) scale scores at day 8 measure: Efficacy: change from baseline in the global assessment of functioning measured by the Global Assessment of Functioning (GAF) scale scores at day 8 measure: Efficacy: change from baseline in the anxiety symptoms measured by the Hamilton Anxiety Rating Scale (HAM-A) scale scores at day 8 measure: Efficacy: change from baseline in the depressive symptoms measured by the Hamilton Depression Rating Scale (HAM-D) scale scores at day 8 measure: Efficacy: change from baseline in the Clinician-Rated Dimensions of Psychosis Symptom Severity (CRDPSS) scale scores at day 8 measure: Change from baseline in plasmatic homocysteine (umol/L) measure: Patient Reported Outcome: change from baseline in the Profile of Mood States (POMS) scores at day 8 measure: Patient Reported Outcome: change from baseline in the mood state Visual Analogue Scale (VAS) scores at day 8 sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clinica Universidad de Navarra status: RECRUITING city: Pamplona state: Navarra zip: 31008 country: Spain name: Jose Maria Galindo role: CONTACT phone: 34 948 255400 phoneExt: 2725 email: ucicec@unav.es lat: 42.81687 lon: -1.64323 hasResults: False
nctId: NCT06387758 id: UMMC-IRB-2022-473 briefTitle: Low Systemic/High Local Exercise Load in Peds SCD overallStatus: RECRUITING date: 2023-09-19 date: 2025-06-30 date: 2025-06-30 date: 2024-04-29 date: 2024-04-29 name: University of Mississippi Medical Center class: OTHER name: University of Alabama at Birmingham briefSummary: This research study wants to learn about what kind of exercise is best for kids with sickle cell disease. Participating children will have a small amount of blood drawn one time at the beginning of the study. Children will then complete some questionnaires that measure pain, physical function, and emotions (depression, anxiety) and complete some tests that measure physical fitness at the beginning and end of the study. Children will be randomized to either a home-based telehealth (1) walking or (2) strengthening exercise program that lasts for 8-weeks, 3-x week, for 45 minutes each session. Children's participation will last up to 10 weeks. conditions: Sickle Cell Anemia in Children studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Low systemic strength training name: Moderate systemic exercise measure: Demographics and medical history (parents) measure: Pediatric Pain Questionnaire measure: Functional Disability Inventory measure: NIH PROMIS 2582 measure: Heart Rate Variability measure: Heart Rate measure: Blood Pressure measure: Bruininks-Oseretsky Test of Motor Proficiency measure: American Thoracic Society 6-minute walk test measure: Actigraphy measure: Daily diaries measure: Biomarkers measure: Medical Chart Review sex: ALL minimumAge: 12 Years maximumAge: 17 Years stdAges: CHILD facility: University of Mississippi Medical Center status: RECRUITING city: Jackson state: Mississippi zip: 39216 country: United States name: Cynthia Karlson, PhD role: CONTACT phone: 601-984-2723 email: ckarlson@umc.edu lat: 32.29876 lon: -90.18481 hasResults: False
nctId: NCT06387745 id: US-REFERRAL briefTitle: Referral of Patients to Hepatology With Hepatoscope acronym: US-REFERRAL overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-12 date: 2025-12 date: 2024-04-29 date: 2024-04-29 name: University Hospital, Antwerp class: OTHER name: E-Scopics briefSummary: Patients identified as being at risk of liver fibrosis because of a positive Fibrosis-4 (FIB-4) test in the primary care setting will be offered be enrolled in the trial and to undergo an Hepatoscope exam (external non-invasive ultrasound imaging exam) to screen for liver fibrosis (with stiffness measurements) and/or steatosis (with ultrasound parameters related to fatty liver). All patients presenting with a liver stiffness value of at least 6.5 kilopascal (kPa) will be referred to the tertiary hepatology consultations for further assessment. Hepatoscope measurements will be compared to the standard of care for these patients, as defined at the tertiary hepatology center. conditions: Chronic Liver Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 200 type: ESTIMATED name: Hepatoscope measure: Positive Predictive Value for significant fibrosis measure: Correlation of stiffness measurements measure: Concordance of stiffness measurements measure: Diagnostic performance of liver stiffness measurements sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06387732 id: 161223 briefTitle: Mechanisms Underlying Antidepressant Effects of Physical Activity acronym: LIFE overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2027-08 date: 2028-01 date: 2024-04-29 date: 2024-04-29 name: University College, London class: OTHER name: King's College London name: Queen Mary University of London name: University of Dublin, Trinity College briefSummary: It is well established that any level of physical activity can help prevent and treat depression, with more strenuous activity having a greater effect. Understanding the mechanisms driving this antidepressant effect is important because it could allow exercise programmes to be made more effective, accessible, and targeted. Such knowledge could contribute to social prescribing, increasingly a priority for mental healthcare. Importantly, physical activity is highly scalable, low cost, well suited to early intervention, and has beneficial impacts on physical health co-morbidities. This trial may provide initial indications of whether there are sub-groups of depressed individuals who are particularly likely to benefit from physical activity, lead to strategies to personalise physical activity prescription based on motivational factors, and pave the way for augmentative approaches, for example combining physical activity with psychological interventions.
The key objective is to conduct a randomised controlled trial (RCT) in N=250 depressed participants comparing aerobic exercise to a stretching/relaxation control condition, examining a range of mechanistic factors. The proposed trial will examine the impact of physical activity at multiple, linked potential levels of explanation: (1) immune-metabolic markers; (2) dopamine synthesis capacity; (3) activation in the brain's reward and effort processing circuitry;(4) effort-based decision making incorporating computational analysis; and (5) symptom networks based on fine-grained, daily measurements. conditions: Depression studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The trial will use a single-site parallel group design with depressed participants randomised to eight weeks of either 45 minutes of aerobic exercise of moderate-to-vigorous activity (experimental group: three times per week, N=125) or 45 minutes of non-aerobic stretching/guided relaxation (control group: three times per week, N=125). primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The control arm is stretching and relaxation. Prior research indicates that participants have similar efficacy expectations regarding mild stretching and aerobic exercise, which will help to improve masking. Due to the nature of the interventions, it is not possible for the participants to be masked as to the intervention they are undergoing, but all study information will be agnostic about which intervention we expect to be more effective, and all analysis will be performed by blinded staff. The trial will assess expectations and preferences about the intervention conditions, allowing for sensitivity analyses. whoMasked: PARTICIPANT count: 250 type: ESTIMATED name: Aerobic exercise name: Stretching and relaxation measure: Patient Health Questionnaire-9 score measure: Physical activity measure: Aerobic capacity: CPET measure: Ecological Momentary Assessment measure: Inflammatory response (cytokines) measure: Inflammatory response (genetic markers) measure: Inflammatory response (flow cytometry immunophenotype) measure: Neuroendocrine system measure: Metabolic function measure: Dopamine synthesis capacity measure: Functional magnetic resonance imaging (fMRI) during cognitive tasks measure: Online cognitive tasks measure: Depression symptoms measure: Anxiety (GAD7 score) measure: Anxiety (STAI score) measure: Anhedonia (SHAPS score) measure: Anhedonia (DARS score) measure: Apathy measure: Fatigue measure: Cognitive impairment measure: Self-efficacy measure: Self-esteem measure: Sleep quality sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
nctId: NCT06387706 id: GAP briefTitle: The Development of a Gamified Web-based Pain Management Program (GAP) for Community-dwelling Older Adults With Chronic Pain overallStatus: RECRUITING date: 2023-12-01 date: 2024-07-30 date: 2024-11-30 date: 2024-04-29 date: 2024-04-29 name: The Hong Kong Polytechnic University class: OTHER briefSummary: Pain Management in Older Adults: Pain significantly impacts the well-being of older adults, often leading to diminished physical abilities and a reduced quality of life. Despite this, pain management remains suboptimal, with concerns about medication side effects and a tendency to view pain as a natural aspect of aging. Consequently, many seniors are hesitant to use painkillers. As an alternative, non-pharmacological strategies such as educational programs, physical activity, massage, relaxation techniques, and music therapy are gaining traction.
Project Goals: The aims of this initiative include creating a web-based Gamified Pain Management Program (GAP), engaging older adults with chronic pain in the development of GAP, and gathering their feedback on the program's effectiveness. conditions: Chronic Pain Syndrome studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 4 type: ESTIMATED name: Gamified web-based pain management Program measure: Pain Relief sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hong Kong Metropolitan University status: RECRUITING city: Hong Kong country: Hong Kong name: Mimi Mun Yee Tse, PhD. role: CONTACT phone: (852)39708764 email: mmytse@hkmu.edu.hk name: Mimi Mun Yee Mimi Mun Yee, PhD. role: PRINCIPAL_INVESTIGATOR name: Tyrone Tai On Kwok, PhD. role: SUB_INVESTIGATOR name: Timothy Chung Ming Wu, Master role: SUB_INVESTIGATOR lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06387693 id: 24U-1359 briefTitle: Artificial Intelligence in ANOCA acronym: (AI)NOCA overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2028-08 date: 2028-12 date: 2024-04-29 date: 2024-04-29 name: UMC Utrecht class: OTHER briefSummary: Angina pectoris is diagnosed in \>180.000 people in the Netherlands each year. Diagnosis in angina pectoris focuses on epicardial coronary stenosis, the identification of which may lead to guideline-directed medical therapy or revascularization. However, no such stenosis is identified in 40-70% of patients. This condition, angina with no obstructed coronary artery (ANOCA), is more prevalent in women and is related to poor quality of life, high medical expenses, and a higher incidence of adverse events.
The origin of ANOCA can be evaluated during invasive coronary angiography by coronary function testing (CFT) to identify coronary vasomotor disorders. This relates to vasospasm of the coronary artery and microcirculation, or to impaired microvascular vasodilation. For the diagnosis of vasospasm, CFT needs to result in electrocardiographic signs of myocardial ischemia as part of the diagnostic criteria. This is a critical point in the diagnosis of vasospasm, as these signs can be subtle and can vary, and are therefore prone to misinterpretation. Apart from this caveat, the diagnosis approach therefore currently requires an invasive procedure for the diagnosis. This limits the broad application and hampers early identification and treatment of ANOCA.
During CFT, a coronary guide wire is routinely advanced in the coronary artery which also allows obtaining an intracoronary ECG by attaching a sterile alligator clamp to a standard electrocardiogram lead. This allows continuous recording of intracoronary ECG throughout CFT on the same monitor as the routine ECG. This technique can increase sensitivity for myocardial ischemia during CFT. Further, Holter ECG monitoring allows the identification of ischemic changes in the ECG in the outpatient setting. Evidence is lacking on the patterns of myocardial ischemia that occur during spontaneous angina pectoris symptoms in ANOCA patients, and on the sensitivity of Holter ECG for this purpose. Finally, the interpretation of ischemic patterns on ECG tracings can be cumbersome, especially when changes are subtle or change from beat to beat. The use of deep learning techniques allows to automate the interpretation of ECG traces and may improve the standardized diagnosis in ANOCA. conditions: Angina, Stable studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 250 type: ESTIMATED name: Holter monitoring, intracoronary ECG measure: Prevalence of myocardial ischemia in patients with equivocal coronary function test results measure: Diagnostic accuracy of perprocedural Holter ECG monitoring to diagnose coronary vasomotor disorders measure: Diagnostic ccuracy of outpatient Holter monitoring for coronary vasomotor disorders sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06387680 id: 2022/187 briefTitle: The Peanut Ball Use on Labor overallStatus: COMPLETED date: 2023-01-01 date: 2024-03-01 date: 2024-04-01 date: 2024-04-29 date: 2024-04-29 name: Selcuk University class: OTHER briefSummary: The purpose of this study was to evaluate the effect of using peanut balls during labor on labor memory, labor satisfaction, labor length, and neonatal APGAR scores. conditions: Birth Outcome, Adverse conditions: Birth, First conditions: Labor Long conditions: Apgar; 4-7 at 1 Minute studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: PARTICIPANT count: 140 type: ACTUAL name: The Effect of Peanut Ball Use on Labor Memory, Labor Satisfaction, Delivery Length, and Neonatal APGAR Score: A Randomized Controlled Trial measure: Comparison of sociodemographic of pregnant women. measure: Comparison of obstetric characteristics of pregnant women measure: Comparison of postpartum characteristics of pregnant women measure: Comparison of duration of 1st and 2nd stage of labor by group measure: Comparison of 1st and 5th minute APGAR scores of newborns by group measure: Comparison of the mean scores of the Pregnant Women's Birth Memory and Recall Questionnaire (BirthMARQ) and its subscales by groups measure: Comparison of pregnant women's Birth Satisfaction Scale (BSS) mean scores by groups sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Selcuk University city: Konya zip: 42250 country: Turkey lat: 37.87135 lon: 32.48464 hasResults: False
nctId: NCT06387667 id: FIRTI briefTitle: Characterizing Diversity and Antifungal Resistance in Immunocompromised ICU Patients With Respiratory Tract Infections overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-12-01 date: 2026-06-01 date: 2024-04-29 date: 2024-04-29 name: New Valley University class: OTHER briefSummary: Immunocompromised individuals face a heightened risk of life-threatening fungal infections, which arise from a multitude of environmental and commensal fungi. Surveillance data from ICUs worldwide identifies Candida spp. as the dominant foe, responsible for 80% of such infections, earning it the dubious distinction of being the third most prevalent pathogen. While C. albicans holds the dubious crown as the most common Candida offender, recent years have witnessed a concerning trend toward non-Albicans candida, raising concerns about potential antifungal resistance. conditions: Immunocompromised ICU Patients With Respiratory Tract Infections studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Immunocompromised ICU Patients with Respiratory tract infections primaryPurpose: DIAGNOSTIC masking: NONE count: 250 type: ESTIMATED name: Complete blood count name: C-reactive protein, urea, creatinine, Random blood glucose (RBG), aspartate aminotransferase (AST), alanine aminotransferase (ALT) name: CT chest name: Microscopic examination name: culture and sensitivity measure: Number of fungal species causing pneumonia in immunocompromised ICU patients measure: Determine the antifungal susceptibility profiles of the identified fungal isolates. measure: Number of associated specific patient factors with the type or antifungal resistance of fungal infections sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06387654 id: RC31/23/0361 briefTitle: Clinico-biological Collection of Autoimmune, Dysimmune or Auto-inflammatory Dermatological Diseases acronym: TekAPo overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2029-04 date: 2034-04 date: 2024-04-29 date: 2024-04-29 name: University Hospital, Toulouse class: OTHER briefSummary: The aim of this project is to start a biological and clinical collection of patients presenting autoimmune, dysimmune or auto-inflammatory dermatological diseases. This collection will provide appropriate biological samples to identify new biomarkers and to be accessible to the medical, scientific and industrial communities for the identification of new therapeutic strategies. conditions: Autoimmune Bullous Dermatosis conditions: Systemic Autoimmune Diseases With Dermatological Presentation conditions: Dysimmune Dermatological Diseases conditions: Auto-inflammatory Dermatological Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 800 type: ESTIMATED name: Blood sampling name: Remainders of samples taken as part of the treatment measure: Building a collection of biological samples and clinical-biological data from patients with autoimmune, dysimmune or auto-inflammatory dermatological disease measure: Identification of new autoantibodies measure: Identification of biomarkers regarding the severity (such as cytokines, survival factors) in order to help the therapeutic decisions measure: Exploration of the pathophysiological mechanisms of rare autoimmune dermatological pathologies measure: Comparison of blood cells populations determinants with flow cytometry, before and after cell therapy and in patients responder or not responder to cell therapy sex: ALL minimumAge: 6 Years maximumAge: 99 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Purpan University Hospital city: Toulouse zip: 31059 country: France name: Chloé BOST, MD, PhD role: CONTACT phone: 5 61 77 61 44 phoneExt: 0033 email: bost.c@chu-toulouse.fr lat: 43.60426 lon: 1.44367 hasResults: False