hackint0sh/New-Dataset huggingface dataset:
Investigators will compare the PSI and conventional groups to see if the PSIs are more accurate than the conventional method. conditions: Retrognathia conditions: Malocclusion, Angle Class II studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: The care provider and the investigator are blinded up to the selection of the device used for the surgery, as blinding is no longer possible from this state. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: Patient-specific implants name: Conventional mini-plates measure: The accuracy of segmental Le Fort I bone movements measure: The stability of segmental Le Fort I bone movements measure: The stability of the upper airway measure: The Diagnostic Criteria for Temporomandibular Disorders Symptom questionnaire measure: The Jaw Functional Limitation Scale measure: The STOP-BANG - Snorting, Tiredness, Observed apnea, blood Pressure, BMI, Age, Neck circumference, Gender questionnaire measure: The Epworth Sleepiness Scale questionnaire measure: The occlusion including horizontal/vertical overlap sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital of Southern Denmark status: RECRUITING city: Esbjerg zip: 6700 country: Denmark name: Michael B Holte, ph.d. role: CONTACT phone: +4520645760 email: Michael.Boelstoft.Holte@rsyd.dk lat: 55.47028 lon: 8.45187 hasResults: False
nctId: NCT06297096 id: NIGRIR_004NINTOC-TU briefTitle: Study of the Efficacy of Nintedanib+Tocilizumab in Patients With Systemic Sclerosis and Interstitial Lung Disease acronym: NINTOC-TU overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-12-30 date: 2028-03-30 date: 2024-03-06 date: 2024-03-21 name: National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland class: NETWORK name: Medical Research Agency, Poland briefSummary: The study includes adult patients with systemic sclerosis (SSc) with interstitial lung disease (ILD) to evaluate the efficacy and safety of nintedanib plus tocilizumab combination therapy compared to standard therapy (methotrexate, mycophenolate mofetil) for 56 weeks. conditions: Systemic Sclerosis conditions: Interstitial Lung Disease studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 86 type: ESTIMATED name: Tocilizumab name: Nintedanib name: Standard therapy measure: The decrease in forced vital capacity (FVC) of the lungs measure: Change in percent lung involvement measure: Assessment of absolute changes in DLCO measure: Assessment of the absolute changes in predicted FVC% measure: Change in the Six-minute walk test (6MWT) result measure: Change in the Health Assessment Questionnaire-Disability Index (HAQ-DI) score measure: A change in the patient's global assessment of disease activity measure: A change in the physician's global assessment of disease activity measure: Assessment of the absolute changes from baseline in total scores in St. George's Respiratory Questionnaire (SGRQ) measure: Assessment of absolute changes compared to baseline values on the modified Rodnan skin Score (mRSS) measure: Percentage of participants with threshold improvement from baseline in modified Rodnan skin Score (mRSS) measure: Percentage of participants with modified Rodnan skin Score (mRSS) improvement greater than or equal to (>/=) 20%, 40%, or 60% sex: ALL minimumAge: 18 Years maximumAge: 74 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centrum Wsparcia Badań Klinicznych city: Warsaw state: Mazowieckie zip: 02-637 country: Poland name: Justyna Kwiatkowska-Golańska role: CONTACT phone: 22 6880632 phoneExt: +48 email: justyna.kwiatkowska-golanska@spartanska.pl name: Maria Maślińska, PhD, MD role: PRINCIPAL_INVESTIGATOR lat: 52.22977 lon: 21.01178 hasResults: False
nctId: NCT06297057 id: 2021.07 briefTitle: Acquisition and Analysis Protocol Optimization of Neurophysiological Data Neurorehabilitation Settings acronym: MEEGOPTI overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-03 date: 2026-03 date: 2024-03-06 date: 2024-03-06 name: IRCCS San Camillo, Venezia, Italy class: OTHER name: University Ghent name: University of Padova briefSummary: The study aims to optimize and validate protocols for acquiring neurophysiological data, specifically resting state functional connectivity, using advanced research techniques (hdEEG and MEG) and a user-friendly device (MUSE). Previous studies have extensively explored functional connectivity repeatability in resting conditions using functional MRI, yet few have focused on hdEEG and MEG data. Additionally, the impact of subjects' eye conditions (open or closed) during resting state recordings on network identification remains debated.
Therefore, to meet these goals, the present study will consist of multiple recordings of brain activity: by high-density electroencephalography (hdEEG), magnetoencephalography (MEG), and low-density EEG with a MUSE handheld device, during five experimental blocks on healthy subjects. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 15 type: ESTIMATED name: Neurophysiological Recordings measure: Neurophysiological data acquisition protocol - resting state measure: Neurophysiological data acquisition protocol - resting state measure: Neurophysiological data acquisition protocol - auditory stimulation sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: San Camillo IRCCS s.r.l. city: Venice-Lido state: Venice zip: 30126 country: Italy lat: 45.4131 lon: 12.3742 hasResults: False
nctId: NCT06297044 id: 2017.20 briefTitle: Neural and Cognitive Correlates of Pragmatic Abilities acronym: APACS_Neuro overallStatus: ACTIVE_NOT_RECRUITING date: 2018-03-29 date: 2025-12-31 date: 2025-12-31 date: 2024-03-06 date: 2024-03-06 name: IRCCS San Camillo, Venezia, Italy class: OTHER briefSummary: Pragmatics of language refers to the set of abilities that allow one to use and interpret language according to context and, in general, to communicate effectively. Disorders in the pragmatics of language are prevalent in various clinical populations. They are a cause of social withdrawal and worse quality of life, both for patients directly affected and for their family members. Despite this, this type of disorder is rarely considered in neuropsychological assessment and rehabilitation.
This study's objective is to characterize pragmatic deficits in various neurological populations, allowing for the most accurate diagnosis possible and leading to the planning of personalized and effective Rehabilitation Plans. conditions: Right Hemispheric Stroke conditions: Left Hemispheric Stroke conditions: Traumatic Brain Injury conditions: Right Hemispheric Brain Tumor conditions: Left Hemispheric Brain Tumor conditions: Mild Cognitive Impairment conditions: Healthy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 324 type: ESTIMATED name: Neuropsychological assessment measure: Pragmatic Profile measure: Theory of Mind measure: Functional Communication Abilities sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: San Camillo IRCCS s.r.l. city: Venice-Lido state: Venice zip: 30126 country: Italy lat: 45.4131 lon: 12.3742 hasResults: False
nctId: NCT06297031 id: 2020/20 briefTitle: Heat Application to the Sacral Region and Pain Level During the First Stage of Labor overallStatus: COMPLETED date: 2020-04-01 date: 2021-05-01 date: 2021-05-30 date: 2024-03-06 date: 2024-03-06 name: Istanbul Demiroglu Bilim University class: OTHER briefSummary: The aim of this study was to determine the effect of hot application applied to the sacral region during first stage of labor on women's pain level and labor process. conditions: Heat Exposure conditions: Labor Pain conditions: Apgar Score conditions: Duration of Labor studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 134 type: ACTUAL name: heat application measure: Change From Baseline labor Pain at three times measure: Duration of the first stage of labor measure: Change From Baseline APGAR score after delivery measure: Change From Baseline Fetal Heart Rate sex: FEMALE minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Demiroglu Bilim University city: Istanbul zip: 34384 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06297018 id: February 18, 2024 briefTitle: Bioenergy, Depression, Anxiety and Stress After Liver Transplantation overallStatus: TERMINATED date: 2024-01-01 date: 2024-02-02 date: 2024-02-09 date: 2024-03-06 date: 2024-03-06 name: Istanbul Aydın University class: OTHER briefSummary: In this study, the investigators aimed to examine the effect of bioenergy application on depression, anxiety and stress after liver transplantation. conditions: Mental Health Issue studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Interventional Crossover Assignment primaryPurpose: BASIC_SCIENCE masking: QUADRUPLE maskingDescription: Experimental whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 140 type: ACTUAL name: Bioenergy application measure: Anxiety, stress, depression: Measurement will be made with the Depression Anxiety Stress 21 Scale (DASS-21: Score range 21-63) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Semra Bulbuloglu city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06297005 id: 21/FFP-P/10154 briefTitle: The Impact of E-cigarettes During Pregnancy on Childhood Health Outcomes Study acronym: ECHO overallStatus: RECRUITING date: 2023-10-09 date: 2027-08-31 date: 2027-08-31 date: 2024-03-06 date: 2024-04-12 name: University College Dublin class: OTHER name: Royal College of Surgeons, Ireland briefSummary: Tobacco smoking in pregnancy is now widely accepted as having adverse health outcomes for both the mother and fetus. Tobacco smoking in pregnancy is associated with increased incidence of miscarriage, stillbirth and preterm birth as well as low birthweight, respiratory infections, wheeze and asthma in childhood. E-cigarettes are a popular method for trying to quit smoking in Ireland and there has been an explosion in the use of e-cigarettes over the past ten years. However, there is currently insufficient evidence on their long-term safety and effectiveness as a smoking cessation tool. E-cigarettes contain varying combinations of compounds and flavours which are used differently in different e-cigarette types, with unknown long-term effects. Research has shown that pregnant women perceive e-cigarettes to be a healthier option when compared with tobacco smoking. But, there is very little known about the long-term health impact of exposure of unborn babies to e-cigarettes during pregnancy.
nctId: NCT06296992 id: B2023:035 briefTitle: Type 1 Diabetes, Exercise and Mentoring Trial acronym: TEAM overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2027-05 date: 2024-03-06 date: 2024-03-06 name: University of Manitoba class: OTHER name: Juvenile Diabetes Research Foundation name: Canadian Institutes of Health Research (CIHR) briefSummary: The proposed study aims to improve the psychosocial health of adolescents living with type 1 diabetes (T1D). The study will generate knowledge and support knowledge mobilization about the effectiveness of a novel model of care for psychosocial health and self-management for adolescents living with type 1 diabetes (T1D). The novel model of care is the recruitment and training if young adult mentors to deliver a behavioural intervention that empowers adolescents with T1D to increase daily physical activity. The study will also advance the development and implementation of this peer mentoring model to improve the psychosocial health of adolescents with T1D. conditions: Type 1 Diabetes conditions: Physical Activity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: DOUBLE whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: 12-week TEAM peer mentor program measure: Enrollment rates measure: Adherence to the intervention arms measure: Retention for follow-up measurements measure: Physical activity measure: Quality of Life (DQOL) measure: Quality of Life (PedsQL 4.0) measure: Diabetes Distress measure: Mastery measure: Autonomy measure: Motivation for physical activity (LCE) measure: Readiness for change measure: Motivation to engage in exercise measure: Motivation for Physical Activity (EMI-2) sex: ALL minimumAge: 13 Years maximumAge: 17 Years stdAges: CHILD hasResults: False
nctId: NCT06296979 id: 0881-N-23 briefTitle: Effectiveness of Noninvasive Phrenic Nerve Neuromodulation in Shoulder Pain and Hepatobiliary Visceral Comorbidity. overallStatus: RECRUITING date: 2024-03-20 date: 2026-12-01 date: 2026-12-01 date: 2024-03-06 date: 2024-04-15 name: University of Seville class: OTHER briefSummary: Pain, particularly shoulder pain, is a social and economic problem worldwide. Although visceral pathology is not yet taken into account in the diagnosis of these pains, it is likely that on numerous occasions the hepatobiliary visceral condition causes referred pain in the metameric area belonging to the shoulder due to the involvement of the phrenic nerve. Therefore, the aim of this project is to study the response of treatment by neuromodulation of the phrenic nerve for shoulder pain in patients with associated hepatobiliary pathologies, assessing the possible visceral involvement in the symptomatology. conditions: Shoulder Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 34 type: ESTIMATED name: Phrenic nerve neuromodulation name: common Physical therapy measure: Numeric Pain Rating Scale measure: Algometry measure: Goniometry passive measure: Quick Dash questionnaire measure: Goniometriy active sex: ALL minimumAge: 18 Years maximumAge: 64 Years stdAges: ADULT facility: Centro de Salud Ronda Histórica status: RECRUITING city: Sevilla zip: 41008 country: Spain name: Deseada López Carballo, Dra role: CONTACT email: deseada.lopez.sspa@juntadeandalucia.es lat: 37.38283 lon: -5.97317 facility: Centro de Salud las Letanías status: RECRUITING city: Sevilla zip: 41013 country: Spain name: Alicia Valero Sáinz role: CONTACT phone: 649532242 phoneExt: +34 email: aliciavalerio@hotmail.com lat: 37.38283 lon: -5.97317 facility: Centro de Salud Bellavista status: RECRUITING city: Sevilla zip: 41014 country: Spain name: María Isabel Morilla Párraga role: CONTACT phone: 609582376 phoneExt: +34 email: fisioaljarafe@gmail.com lat: 37.38283 lon: -5.97317 hasResults: False
nctId: NCT06296966 id: VP-VSJ-110-2201 briefTitle: A Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye overallStatus: RECRUITING date: 2024-02-29 date: 2024-07 date: 2024-07 date: 2024-03-06 date: 2024-03-06 name: Vanda Pharmaceuticals class: INDUSTRY briefSummary: The purpose of this study is to determine the safety and efficacy of VSJ-110 compared to placebo in the treatment of dry eye. conditions: Dry Eye studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: VSJ-110 name: Placebo measure: Schirmer's Tear Test measure: Ocular Staining measure: Eye Dryness Score (EDS) of the Visual Analogue Scale (VAS) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Vanda Investigational Site status: RECRUITING city: Andover state: Massachusetts zip: 01810 country: United States name: Vanda Pharmaceuticals Inc. role: CONTACT phone: 202-734-3400 email: clinicaltrials@vandapharma.com lat: 42.65843 lon: -71.137 hasResults: False
nctId: NCT06296953 id: PeriSaFe01 id: CIV-23-11-044875 type: OTHER domain: Swedish Medical Product Agency briefTitle: Safety & Feasibility of PERIsign System in Demonstrating Involuntary Muscle Defense as a Sign of Peritonitis in Subjects With Appendicitis acronym: PeriSaFe01 overallStatus: RECRUITING date: 2024-03-15 date: 2024-09-01 date: 2024-12-01 date: 2024-03-06 date: 2024-04-22 name: STB INN AB class: INDUSTRY name: Scandinavian CRO name: Region Halland briefSummary: This will be an explorative, proof-of-principle, open, multi-center investigation.
All subjects will undergo PERIsign examinations. Subjects with suspected appendicitis will undergo 1-2 PERIsign examinations before their planned appendectomy surgery. For the healthy volunteers, there is only 1 PERIsign examination. During each examination, 4 PERIsign curves will be obtained, one from each quadrant of the abdomen. The attending physician will interpret the appearance of the PERIsign curves of all subjects, including those from the healthy volunteers. The duration of the PERIsign examination will be documented, and usability data will be gathered, including the need for sensor adjustments, subject perception of the examination, and any discomfort experienced. In addition, blinded physicians will evaluate all subjects' PERIsign curves and determine whether each subject has involuntary muscle defense as a sign of peritonitis. These blinded physicians will have access to all 4 PERIsign curves obtained during each examination, while other data will not be disclosed to them.
Safety will be evaluated through analysis of reported adverse events and device deficiencies conditions: Appendicitis Acute conditions: Appendicitis conditions: Abdominal Pain conditions: Peritonitis studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 40 type: ESTIMATED name: PERIsign examination measure: Proportion of subjects experiencing any adverse events during the examination measure: Proportion of device deficiencies during the evaluation measure: To estimate the sensitivity and specificity of diagnosing pathological muscle defense when using the PERIsign system measure: Proportion of examinations of the PERIsign system that its performed without usability issues. sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hallands Sjukhus Halmstad status: RECRUITING city: Halmstad country: Sweden name: Cleas Hjalmarsson, Ass. Prof. role: CONTACT name: Åsa Anveden, PhD role: SUB_INVESTIGATOR lat: 56.67446 lon: 12.85676 facility: Hallands Sjukhus Varberg status: RECRUITING city: Varberg country: Sweden name: Claes Hjalmarsson, ass. Prof role: CONTACT name: Stefan Lindskog, ass. prof role: PRINCIPAL_INVESTIGATOR lat: 57.10557 lon: 12.25078 hasResults: False
nctId: NCT06296940 id: WEST 2.0 briefTitle: Written Exposure in Substance Treatment acronym: WEST overallStatus: RECRUITING date: 2022-12-01 date: 2024-06-15 date: 2024-12-31 date: 2024-03-06 date: 2024-03-06 name: Potomac Health Foundations class: OTHER name: University of Maryland, Baltimore County briefSummary: The purpose of this pilot randomized clinical trial is to test the feasibility and efficacy of written exposure therapy (WET) for posttraumatic stress disorder (PTSD) within the context of residential substance use disorder (SUD) treatment. All participants meet criteria for PTSD and are in a short term residential SUD treatment program (target residential treatment duration = 28 days) regardless of the research. The main questions the study aims to answer are: 1) Is the delivery of WET feasible in short term residential SUD treatment for individuals with severe SUD; 2) Do participants in the TAU+WET condition have greater reductions in PTSD symptoms pre/post treatment compared to participants in TAU alone? conditions: Posttraumatic Stress Disorder conditions: Substance Use Disorders studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: We are conducting a randomized controlled trial of approximately 50 randomized subjects (up to 100 total enrollments) who will be assigned 1:1 to treatment as usual (TAU) or TAU+WET. primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Written Exposure Therapy name: Treatment as Usual measure: Efficacy of WET measure: Feasibility of WET delivered in residential SUD treatment context measure: Acceptability of WET delivered in residential SUD treatment context sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Maryland Treatment Centers status: RECRUITING city: Baltimore state: Maryland zip: 21229 country: United States name: Kevin Wenzel, PhD role: CONTACT phone: 410-233-1400 email: kwenzel@marylandtreatment.org name: Marc Fishman, MD role: CONTACT phone: 410.233.1400 email: mfishman@marylandtreatment.org lat: 39.29038 lon: -76.61219 hasResults: False
nctId: NCT06296927 id: SumeyyeKose-E.138186 briefTitle: The Effect of the Emotional Freedom Technique on Perceived Pain, Situational Anxiety, Cortisol and Satisfaction Levels in Mammography Screening. overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-01 date: 2025-03-01 date: 2024-03-06 date: 2024-03-06 name: Saglik Bilimleri Universitesi class: OTHER briefSummary: This study was planned to determine the effect of Emotional Freedom Technique on perceived pain level, situational anxiety, salivary cortisol and satisfaction level during mammography screening. conditions: Mammography Screening conditions: Pain conditions: Anxiety studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study is a randomized controlled two-group study. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 76 type: ESTIMATED name: Emotional Freedom Technique measure: Anxiety measure: Pain Level measure: Satisfaction Level measure: Cortisol Level sex: FEMALE minimumAge: 40 Years maximumAge: 50 Years stdAges: ADULT facility: Pendik District Health Directorate Maternal Child Health and Family Planning Center city: Istanbul country: Turkey name: SUMEYYE KOSE role: CONTACT phone: 2163961630 phoneExt: 6173 email: sumeyyekose28@gmail.com name: Sümeyye Köse, Phd Student role: PRINCIPAL_INVESTIGATOR name: Handan Özcan, Assoc.Prof role: PRINCIPAL_INVESTIGATOR name: Türkinaz Aşti, Prof.Dr. role: SUB_INVESTIGATOR name: Fatih Hacımustafaoğlu, Lecturer Dr. role: SUB_INVESTIGATOR lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06296901 id: 202310353 briefTitle: To Wipe or Not To Wipe?: That Is The Question overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-10 date: 2024-03-06 date: 2024-03-06 name: Joanna A. Orzel class: OTHER briefSummary: The primary aim of this randomized control trial is to characterize whether a mid-stream clean catch sample using a cleansing wipe in the setting of symptomatic UTI in a female patient is associated with a lower rate of contamination. We hypothesize that using a perineal cleansing wipe at the time of a midstream urine sample will decrease rates of contamination for female patients with a symptomatic UTI. conditions: Urinary Tract Infections studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 600 type: ESTIMATED name: Perineal Wipe measure: Rate of Contamination sex: FEMALE minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False