hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06334991 id: QUILT-106 briefTitle: Study for Subjects With Relapsed/Refractory Non-Hodgkin Lymphoma overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-03-30 date: 2027-03-30 date: 2024-03-28 date: 2024-03-28 name: ImmunityBio, Inc. class: INDUSTRY briefSummary: Open Label, Phase 1 study of CD19 t-haNK as a single agent and combination with rituximab in subjects with selected CD19+ and CD20+ R/R B-cell non-Hodgkin Lymphoma( NHL). conditions: Non-Hodgkin Lymphoma Refractory/ Relapsed studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: The study is open label, for Refractory/ Relapsed Non-Hodgkin Lymphoma. Up to 10 subjects will receive at least 1 dose of study drug. The initial 3 subjects will receive study drug in a staggered fashion, with a 7 day interval between each subject to evaluate any toxicities. primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: CD19 t-haNK measure: Overall safety evaluation in combining CD19 t haNK as a single agent with rituximab measure: Incidence of treatment-emergent AEs (TEAEs) and serious AEs (SAEs) graded using the National Cancer Institute (NCI) CTCAE Version 5.0.Clinically important changes in safety laboratory tests and vital signs. measure: Best tumor response in accordance with Lymphoma Response to Immunomodulatory Therapy Criteria (LYRIC). sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06334978 id: 1-2024 briefTitle: The Effectiveness of Osteopathic Treatment in Cervical Whiplash. overallStatus: COMPLETED date: 2021-01-13 date: 2022-07-10 date: 2022-08-10 date: 2024-03-28 date: 2024-03-28 name: Hospital San Juan de Dios del Aljarafe de Sevilla class: OTHER name: Hospital Universitario Virgen Macarena name: University of Seville briefSummary: Introduction. Whiplash is common after road traffic accidents and affects millions of people worldwide; 50% develop chronic symptoms and 15% have their ability to work compromised. The aim of this study was to evaluate an osteopathic intervention in whiplash and determine whether pain, mobility and quality of life improve with respect to conventional treatment.
Methodology. A randomised, controlled clinical trial between 13/01/2021_10/08/2022 conducted at Hospital San Juan de Dios del Aljarafe. The control group followed the hospital's protocol, and the experimental group also received an osteopathic intervention. Statistical analysis: Statistical Package for the Social Sciences (SPSS-vs27.0); intra-subject comparison: Student's t-test for dependent samples, Wilcoxon's test; inter-group comparisons: Student's t-test for independent samples, Mann-Whitney U, chi-squared. conditions: Whiplash Injury of Cervical Spine conditions: Osteopathia conditions: Quality of Life conditions: Chronic Pain Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescription: Randomised controlled clinical trial primaryPurpose: SUPPORTIVE_CARE masking: TRIPLE maskingDescription: The study was blinded: patients were unaware of the group to which they had been assigned. Patient evaluations at the start and end were performed by a physiotherapist different to the one performing the intervention, who was also unaware of the patient assignment. The same person performed all therapies for both the control and intervention groups and was unaware of the pre-intervention measurements. The statistician who analysed the data was also unaware of the group to which each patient belonged. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 52 type: ACTUAL name: Osteopathic intervention measure: Cervical Pain measure: Quality of life in Whiplash Disability measure: Functionality-Neck Disability Index measure: Number of sites measure: Number of analgesics measure: Measuring mobility using inclinometry measure: Measurement of pressure pain using algometry sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: María Victoria RUIZ ROMERO city: Bollullos de la Mitación state: Sevilla zip: 41110 country: Spain lat: 37.34014 lon: -6.13719 hasResults: False
nctId: NCT06334965 id: APHP230279 briefTitle: Multi-modal Characterisation of Hepatocellular Carcinoma (HCC) Treated With Targeted Radionuclide Therapy (TRT): Prospective Interventional Multicentre National Cohort acronym: OPERANDI-HCC overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2027-11 date: 2029-09 date: 2024-03-28 date: 2024-03-28 name: Assistance Publique - Hôpitaux de Paris class: OTHER briefSummary: OPERANDI project aims to address unmet clinical needs in the current management of advanced-stage HCC treated with TARE by exploring new opportunities provided by imaging-based artificial intelligence (AI) and data augmentation, simultaneous PET-MRI imaging, and novel approaches to increase patient selection and TARE efficacy (genomic profiling, radiopotentiators, and new radionuclides). The research aim to identify predictive and early markers indicative of TARE effectiveness based on a large prospective cohort of HCC patients. This cohort will be used to uncover relevant predictive signatures within the morphological, functional, and molecular imaging data using novel imaging-based AI approaches with a new patient imaging pathway including simultaneous 18F-Choline PET-MRI.
Considering this global objective, the objective of this clinical research protocol is to provide clinical, molecular and imaging data in a prospective standardized study, notably by performing systematic pretherapeutic and follow-up PET-MRI, in patients with HCC treated with TARE. conditions: Hepatocellular Carcinoma conditions: Radioembolization studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 180 type: ESTIMATED name: Simultaneous 18F-Choline PET-MRI measure: Clinical response sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beaujon hospital city: Clichy country: France name: Mohamed BOUATTOUR role: CONTACT lat: 48.90018 lon: 2.30952 facility: CHU Nantes city: Nantes country: France name: Yann TOUCHEFEU role: CONTACT lat: 47.21725 lon: -1.55336 hasResults: False
nctId: NCT06334952 id: RCAPHM23_0074 id: ID-RCB type: OTHER domain: 2023-A02482-43 briefTitle: Efficacy of Personnalized Transcranial Direct Current Electrical Stimulation (tDCS) in Drug-resistant Epileptic acronym: GALVANI GS-3 overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-05-31 date: 2027-04-30 date: 2024-03-28 date: 2024-03-28 name: Assistance Publique Hopitaux De Marseille class: OTHER name: CRMBM-CEMEREM name: Institut National de la Santé Et de la Recherche Médicale, France - LTSI name: Neuroelectrics Corporation briefSummary: The goal of this clinical trial is to to obtain a significant decrease in seizure frequency in patients with refractory focal epilepsy after applying treatment of cathodal tDCS, compared to sham stimulation drug-resistant epileptic patient. The main questions it aims to answer are:
nctId: NCT06334939 id: KSH.2023-32 briefTitle: Bispectral Index, Suppression Rate and Emergence Agitation in Spine Surgeries overallStatus: RECRUITING date: 2024-01-01 date: 2024-05-01 date: 2024-05-30 date: 2024-03-28 date: 2024-03-28 name: Ahmet Yuksek class: OTHER_GOV briefSummary: Emergence agitation; generally refers to a situation that may occur after a surgical intervention or anesthesia. This situation describes the irritability and agitation of the patient during the recovery process and the period of recovery from anesthesia. Recovery agitation may occur when the patient begins to recover and is usually a short-term condition. It resolves spontaneously. However, in some cases, this agitation may be more pronounced and disturbing. This may affect the patient\&#39;s condition and relaxation. Rapid recovery from anesthesia in the clinic is also a risk factor for agitation.
When the literature is examined, there are not enough studies on Bis suppression ratio and its relationship with recovery agitation is not yet known enough. For this purpose, our study aimed to question this relationship. conditions: Emergence Agitation conditions: Anesthesia Recovery conditions: Bispectral Index Monitor studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: PROSPECTIVE count: 80 type: ESTIMATED name: Bispectal index Monitoring measure: Relationship between BIS SR value and Emergence Agitation measure: Relationship between average and lowest BIS values and Emergence agitation sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kocaeli City Hospital status: RECRUITING city: Kocaeli state: Izmıt zip: 41100 country: Turkey name: Mehmet Yilmaz, Associate Proffessor role: CONTACT phone: 505-217-4432 email: drmyilmaz33@gmail.com name: Ahmet Yuksek, Md role: PRINCIPAL_INVESTIGATOR lat: 39.62497 lon: 27.51145 hasResults: False
nctId: NCT06334926 id: EK 18-002-VK briefTitle: BMI and Lymph Node Count in Colorectal Cancer overallStatus: COMPLETED date: 2017-12-01 date: 2020-03-31 date: 2020-03-31 date: 2024-03-28 date: 2024-03-28 name: Klinikum Floridsdorf class: OTHER name: Medical University of Vienna name: Klinik Favoriten name: Salzkammergut Klinikum Vöcklabruck briefSummary: Background and aim: Colorectal Cancer (CRC) is one of the most frequent cancer entities in the western world. It is known that obesity is one of the major risk factors for CRC. In contrast, mild obesity seems to have a positive effect on postoperative outcome, which is known as the "obesity paradox". Also, the number of resected lymph nodes (LN) during surgery is very important for correct staging. The aim of the present project is to evaluate the impact of BMI and LN-yield on long term overall survival (OS) of CRC patients treated with curative intent.
Methods: Patients treated for CRC between 1998 and 2011 at the Klinik Favoriten in Vienna, Austria were analyzed in this retrospective single-center cohort analysis concerning OS. conditions: The Aim of This Study is to Determine the Influence of BMI and Lymph Node Status on OS in CRC Patients in the Long Term studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 1192 type: ACTUAL name: no intervention, retrospective data analysis measure: overall survival sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Klinik Floridsdorf city: Wien zip: 1210 country: Austria lat: 48.20849 lon: 16.37208 hasResults: False
nctId: NCT06334913 id: IRAS 332286 briefTitle: A Prospective Patient Reported Outcomes and Wearables Study in Myeloproliferative Neoplasms overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2029-04-01 date: 2029-04-01 date: 2024-03-28 date: 2024-03-28 name: Guy's and St Thomas' NHS Foundation Trust class: OTHER briefSummary: The investigators will assess the use of a smart phone app to monitor patient reported outcomes and record biometric data in patients with myeloproliferative neoplasms. conditions: Myeloproliferative Neoplasm studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED measure: Patient reported outcomes - Myeloproliferative Neoplasm-10 Total Symptom Score measure: Healthcare adherence measure: Biometric data analysis - activity index measure: Biometric data analysis - sleep score measure: Biometric data analysis - heart rate sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06334900 id: 69HCL24_0297 briefTitle: Retrospective Analysis of the French National Cohort of Patients With GAD Antibodies and Cerebellar Ataxia acronym: Ata-GAD overallStatus: RECRUITING date: 2023-10-01 date: 2024-01-01 date: 2024-06-30 date: 2024-03-28 date: 2024-03-28 name: Hospices Civils de Lyon class: OTHER briefSummary: Glutamic acid decarboxylase (GAD) is an enzyme whose function in the body is to decarboxylate glutamate to GABA. GAD65 antibodies (GAD65Ab) have been associated with type-1 diabetes (80% of new-onset patients) and various neurological conditions, mainly stiff-person syndrome (SPS/PERM), cerebellar ataxia (CA), limbic encephalitis (LE) and temporal lobe epilepsy. These syndromes all seem to result from a reduced transmission of GABA. These neurological conditions are rare and can cause symptoms like confusion, memory loss, muscle stiffness, muscle spasms, behavioural disorders, and pharmacoresistant epilepsy. When finding high levels of GAD65-Ab in the serum, a cerebrospinal fluid (CSF) sample should be taken to look for oligoclonal IgG bands and intrathecal GAD-Ab production to prove an auto-immune cause for the various neurological symptoms. conditions: GAD-receptor Antibodies-associated Encephalitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 100 type: ESTIMATED name: GAD patients measure: GAD Patient sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hôpital Neurologique Pierre Wertheimer / Groupement Hospitalier Est status: RECRUITING city: Bron zip: 69677 country: France name: Jérôme Honnorat, professor role: CONTACT phone: +33 4 72 35 78 06 email: jerome.honnorat@chu-lyon.fr lat: 45.73333 lon: 4.91667 hasResults: False
nctId: NCT06334887 id: PID2021-124409OB-I00_O3 briefTitle: esTOCma, an App Used by Teachers: an RCT overallStatus: RECRUITING date: 2024-02-26 date: 2024-05-31 date: 2024-05-31 date: 2024-03-28 date: 2024-04-01 name: University of Valencia class: OTHER name: Ministry of Science and Innovation briefSummary: The aim of the present study is to assess the efficacy of a mobile application called esTOCma in promoting mental health literacy, reducing stigmatizing attitudes related to the Obsessive-Compulsive Disorder (OCD) and improving teachers' confidence in dealing with students that might have OCD. A parallel, randomized controlled trial with two conditions (experimental and control group) will be carried out in a sample of teachers that work in primary and secondary education. Pre-post changes will be assessed. Experimental group will use the app until they finish it (within a set period of 10 days), whereas control group will do nothing for 10 days. Primarily, it is expected that after the use of the app, participants will show an improvement in OCD-related literacy, stigmatizing attitudes, desired social distance and their comfort, confidence and perceived ability in teaching and handling students with OCD. Secondarily, the investigators hypothesize that experimental group might show a reduction in obsessive-compulsive symptoms. conditions: Obsessive-Compulsive Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A parallel randomized controlled trial (RCT) with two arms: experimental group (use of esTOCma) and control group (untreated) will be carried out.
As participants enroll in the study, those that meet the inclusion criteria will be randomized into experimental or control group and into contamination or aggressive vignette (see Outcome Measures). Everyone will complete the baseline measures (T1). Then, those assigned to experimental group will use the app esTOCma until they finish it (they will be given a 10-days deadline), whereas control group will do nothing for 10 days. After that, all the participants will complete again the assessment instruments (T2). primaryPurpose: PREVENTION masking: SINGLE whoMasked: PARTICIPANT count: 90 type: ESTIMATED name: Use of esTOCma measure: Change in general OCD literacy measure: Change in OCD literacy associated with a vignette measure: Change in stigmatizing attitudes related to OCD associated with a vignette measure: Change in comfort in addressing OCD measure: Change in desired social distance measure: Change in obsessive-compulsive symptoms sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Valencia/ Universitat de València status: RECRUITING city: Valencia zip: 46010 country: Spain name: Gemma Garcia-Soriano, PhD role: CONTACT lat: 39.46975 lon: -0.37739 hasResults: False
nctId: NCT06334874 id: REC-FPFUE-32/2023 briefTitle: Study of the Efficacy and Safety of Antioxidants Astaxanthin as an Adjuvant Therapy for Community Acquired Pneumonia Patients. overallStatus: RECRUITING date: 2024-04-01 date: 2024-07-01 date: 2024-08-01 date: 2024-03-28 date: 2024-04-12 name: Future University in Egypt class: OTHER briefSummary: Community acquired pneumonia (CAP) is one of the most common and morbid conditions encountered in clinical practice, which causes serious morbidity worldwide. In CAP, oxidative stress is linked to inflammation, demonstrated by increased production of interleukin (IL)-6 and tumor necrosis factor (TNF)-α, which attract inflammatory cells and increase oxidant production by these cells. Attenuation of oxidative stress via antioxidants would be expected to result in reduced pulmonary damage. Antioxidants have been found to be effective in alleviating lung injury and protecting against damage of other organs. conditions: Community-acquired Pneumonia studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Astaxanthin Oral Capsule name: Placebo measure: change in IL-6 after treatment in the ASX group compared with those in the control group. measure: change in IL-10 after treatment in the ASX group compared with those in the control group. measure: change in tumor necrosis alpha after treatment in the ASX group compared with those in the control group. measure: difference in CURB 65 scores after treatment in the ASX group compared with the control group. measure: o Adverse drug reactions related to ASX as increase bowel movement, stomach pain and increase PT and APTT will be assessed. measure: Length of hospital and ICU stay. sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Elmatarya Teaching Hospital status: RECRUITING city: Cairo zip: 4650201 country: Egypt name: fatma makram role: CONTACT phone: 01015000329 email: fatma.aboelhassan@fue.edu.eg name: eman elmokadam role: CONTACT email: Eman.abdellatif@fue.edu.eg lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06334861 id: 5001 briefTitle: Multidisciplinary Hospital-Territory Vaccine Center: a Model for Achieving the Herpes Zoster Vaccine Coverage acronym: CeVOT-Her-Zo overallStatus: RECRUITING date: 2022-06-23 date: 2024-05-15 date: 2024-06-30 date: 2024-03-28 date: 2024-03-28 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: The National Vaccination Program, updated by the Ministry of Health in 2021, provides a new vaccination opportunity for frail patients against Herpes zoster virus (HZ). The new treatment option, on the other hand, is designed by combining VZV-specific antigen (gE) with an adjuvant system (AS01B) to induce antigen-specific cellular and humoral immune responses in individuals with preexisting immunity to VZV. Efficacy, assessed in people given two doses 2 months apart, is around 97% in those aged 50 years and 91% in those over 70 years. In the studies conducted, HZ-related hospitalizations were significantly reduced. The vaccine schedule calls for the administration of two doses 2 months apart. The current HZ Vaccination Program implemented at the regional level recommends its active and free offer in people from 18 years of age with congenital and/or acquired immunodepression, through a collaborative relationship involving, on the one hand, multispecialist and multiprofessional medical staff and, on the other hand, citizens called to play a role that is no longer passive but the subject of empowerment by consciously making their own health choices. The collaboration with ASL Roma1, in this sense, acquires value as guarantor of the supply of the adjuvanted recombinant anti-HZ vaccine and of the appropriate reporting of vaccination coverage, which to date is still far from the targets set by the PNPV'17-'19 in adults at risk for disease.
The purpose of this study Single-center prospective longitudinal observational cohort study is to verify patients' compliance with the proposed vaccination, the effectiveness of counseling carried out by a multidisciplinary team in the hospital setting. conditions: Herpes Zoster studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 48 type: ESTIMATED name: Herpes Zoster adjuvanted recombinant vaccine measure: Compliance to vaccination sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione Policlinico Universitario A. Gemelli - UCSC status: RECRUITING city: Roma state: RM zip: 00168 country: Italy name: Patrizia Laurenti, MD PHD role: CONTACT email: patrizia.laurenti@policlinicogemelli.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06334848 id: TOT versus mini sling briefTitle: Efficacy of Mini Sling Versus Transobturator Tape in Surgical Management of Women With Stress Urinary Incontinence overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-09 date: 2024-03-28 date: 2024-03-28 name: Ain Shams University class: OTHER briefSummary: To compare the efficacy of mini sling against Transobturator tape for surgical management of women with stress urinary incontinence. conditions: Stress Urinary Incontinence studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 42 type: ESTIMATED name: transobturator tape measure: Comparing Mini Sling and Transobturator Tape in Surgical Management of Women with Stress Urinary Incontinence regarding incidence of complications measure: Comparing Mini Sling and Transobturator Tape in Surgical Management of Women with Stress Urinary Incontinence regarding postoperative pain measure: Comparing Mini Sling and Transobturator Tape in Surgical Management of Women with Stress Urinary Incontinence regarding sexual function sex: FEMALE maximumAge: 60 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06334835 id: 1/23 OSS SDN briefTitle: Long Non-coding RNAs and Their Role on Epigenome as Diagnostic Markers in Childhood Acute Lymphoblastic Leukemia of T Cells. overallStatus: RECRUITING date: 2023-04-30 date: 2023-12-31 date: 2026-05-31 date: 2024-03-28 date: 2024-04-03 name: IRCCS SYNLAB SDN class: OTHER name: Fondazione Santobono Pausilipon briefSummary: Long non-coding RNAs (lncRNAs) are a class of biomarkers of crescent interest in the hematologic and oncologic field.
They do not encode proteins and can alter gene expression by acting on different steps of regulation, including DNA methylation and chromatin structure. Recent data identified recurrent somatic alterations in genes involved in DNA methylation and post-translational histone modifications in T-ALL, suggesting that epigenetic homeostasis is critically required in restraining tumor development in the T-cell lineage. Further, recent studies showed that the expression levels of specific lncRNAs correlate with the prognosis of patients with Acute Lymphoblastic Leukemia of T-cells (T-ALL). The objectives of this research project are to identify T-ALL-specific lncRNAs to be used as new diagnostic and prognostic biomarkers of disease and to explore their role on chromatin reorganization and transcriptional regulation that may lead to the onset and progression of T-ALL. conditions: Acute Lymphoblastic Leukemia, Pediatric studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED name: lncRNA signature analyses measure: Evaluation of the expression of selected lncRNAs in pediatric T-ALL patients and cellular models of T-ALL sex: ALL minimumAge: 1 Year maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Irccs Synlab Sdn status: RECRUITING city: Naples zip: 80143 country: Italy name: Giovanni Smaldone, PhD role: CONTACT phone: 3398768331 email: giovanni.smaldone@synlab.it lat: 40.85216 lon: 14.26811 hasResults: False