hackint0sh/New-Dataset huggingface dataset:
This study may support evidence for an inexpensive alternative means of treatment for patients with or without traumatic sexual history and chronic pelvic pain. conditions: Pelvic Pain conditions: Acupuncture conditions: Gynecology studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Patient sample will be both control and treatment groups. Individuals will not be divided into distinct groups. Patients will serve as their own controls. Control patients will be participating in standard of care therapies including physical therapy, psychotherapy, behavioral health, typical primary care management, etc. as deemed appropriate by the primary care provider for 4 weeks prior to study intervention. The same patients will then be re-evaluated and will be offered Acupuncture with Dragon technique (see attachment Protocol for Needle Insertion) as a means of pain control once per week for 4 weeks. primaryPurpose: TREATMENT masking: NONE count: 64 type: ESTIMATED name: Dragons name: Standard of Care measure: Defense and Veterans Pain Rating Scale (DVPRS) measure: Defense and Veterans Pain Rating Scale (DVPRS) measure: Defense and Veterans Pain Rating Scale (DVPRS) measure: Defense and Veterans Pain Rating Scale (DVPRS) measure: Defense and Veterans Pain Rating Scale (DVPRS) measure: Defense and Veterans Pain Rating Scale (DVPRS) measure: Female Genitourinary Pain Index (GUPI) measure: Female Genitourinary Pain Index (GUPI) measure: Female Genitourinary Pain Index (GUPI) measure: Female Genitourinary Pain Index (GUPI) measure: Female Genitourinary Pain Index (GUPI) measure: Female Genitourinary Pain Index (GUPI) measure: PTSD Checklist for DSM-5 (PCL-5) measure: PTSD Checklist for DSM-5 (PCL-5) measure: PTSD Checklist for DSM-5 (PCL-5) measure: PTSD Checklist for DSM-5 (PCL-5) measure: PTSD Checklist for DSM-5 (PCL-5) measure: PTSD Checklist for DSM-5 (PCL-5) sex: FEMALE minimumAge: 21 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mike O'Callaghan Military Medical Center status: RECRUITING city: Nellis Air Force Base state: Nevada zip: 89191 country: United States name: Amanda J Crawford, MSHS role: CONTACT phone: 702-653-3583 email: amanda.j.crawford.ctr@health.mil lat: 36.24607 lon: -115.05721 hasResults: False
nctId: NCT06388577 id: MEU-HEM-SY-189 briefTitle: The Effect of the Training Programme Based on the Health Promotion Model Given to Parents overallStatus: NOT_YET_RECRUITING date: 2024-05-13 date: 2024-06-13 date: 2024-09-13 date: 2024-04-29 date: 2024-04-29 name: Mersin University class: OTHER briefSummary: This randomised controlled study evaluates the effect of a training programme based on the Health Promotion Model developed for parents of children diagnosed with epilepsy on parents' level of knowledge about epilepsy, parents' general self-efficacy level, parents' health promoting and protective behaviours and the number of hospital admissions of their children. The hypothesis of this study is that education has an effect on these. conditions: Parents conditions: Epilepsy in Children conditions: Disease Management studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Prospective, single-centre, randomised controlled, single-blind interventional study in parallel groups primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: Participants and the person who will perform the statistical analysis will be blinded. Participants will be assigned to intervention and control groups coded as A and B. Afterwards, it will be determined which of the A and B groups belong to the control and intervention groups by drawing lots.It will not be explained to the parents which group they are in, and it will be stated that education about epilepsy will be given. While entering the data, the researcher will enter the data encrypted as A and B in order to prevent measurement bias, the statistical analysis of the data will be carried out according to this encryption and the report of the study will be written in encrypted form. After the statistical analyses of the research are carried out and the research report is written as a result of the data found, it will be explained which of the groups the individuals are included in. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 76 type: ESTIMATED name: Education measure: Parents' level of knowledge about epilepsy evaluated using the Form for the Evaluation of Parents' Level of Knowledge about Epilepsy measure: Self-efficacy evaluated using the General Self-Efficacy Scale measure: Health Promoting and Protective Behaviors evaluated using the Health Promoting and Protective Behaviors Scale measure: Number of Hospital Admissions for Children evaluated using the Evaluation Form for the Number of Hospital Admissions sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Turkey, Mersin University city: Mersin country: Turkey name: Sümerya YASTI, MASTER role: CONTACT email: 2204160171012@mersin.edu.tr name: Hacer ÇETİN, PROFESSOR role: PRINCIPAL_INVESTIGATOR lat: 36.79526 lon: 34.61792 hasResults: False
nctId: NCT06388564 id: INCA34176-254 id: 2022-502168-19-00 type: REGISTRY domain: EU CT Number briefTitle: A Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease overallStatus: NOT_YET_RECRUITING date: 2024-07-08 date: 2027-03-05 date: 2028-09-05 date: 2024-04-29 date: 2024-04-29 name: Incyte Corporation class: INDUSTRY briefSummary: This study will be conducted to determine the preliminary efficacy of axatilimab in combination with ruxolitinib and to assess the contribution of axatilimab to the combination treatment effect in participants with cGVHD. conditions: Chronic Graft-versus-host-disease studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 120 type: ESTIMATED name: Axatilimab name: Ruxolitinib name: Corticosteroids measure: Objective Response Rate measure: Number of participants with Treatment-emergent Adverse Events (TEAEs) measure: Duration of Response measure: Proportion of participants with a ≥ 7-point improvement in modified Lee symptom scale (mLSS) score measure: Best overall response in the first 6 months measure: OR at 12 months, defined as CR or PR at 12 months (C14D1) in the absence of new systemic therapy for cGVHD. measure: Proportion of participants who remain corticosteroid-free measure: Organ-specific response in the first 6 cycles and on study, based on the 2014 NIH Consensus Development Project on Criteria for Clinical Trials in cGVHD. measure: Failure-free Survival (FFS) measure: Axatilimab pharmacokinetic (PK) in Plasma measure: Ruxolitinib PK in Plasma sex: ALL minimumAge: 12 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06388551 id: LY03017/CT-CHN-101 briefTitle: A Phase 1, SAD Study to Evaluate the Safety and Tolerability of LY03017 overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2025-03-30 date: 2025-03-30 date: 2024-04-29 date: 2024-04-29 name: Luye Pharma Group Ltd. class: INDUSTRY briefSummary: This is a phase 1，randomized, double-blind, placebo-controlled, SAD study to evaluate the safety, tolerability and pharmacokinetics of oral LPM526000133 Fumarate Capsules (LY03017) in healthy adult subjects. conditions: Hallucinations and Delusions Associated With Alzheimer's Disease Psychosis conditions: Hallucinations and Delusions Associated With Parkinson Disease Psychosis conditions: Negative Symptoms of Schizophrenia studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: LY03017 name: LY03017-Placebo measure: Incidence and severity of adverse events (AEs) and serious adverse events (SAEs) measure: Maximum observed concentration (Cmax) of LPM526000133 in plasma measure: Time to maximum observed concentration (Tmax) of LPM526000133 in plasma measure: The area under the concentration-time curve from time zero extrapolated to infinity (AUC0-∞) of LPM526000133 in plasma measure: Area under the concentration-time curve from time zero to the time of last quantifiable concentration (AUC[0-last]) of LPM526000133 in plasma measure: Apparent terminal elimination half-life (t1/2) of LPM526000133 in plasma sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Shanghai Mental Health Center city: Shanghai country: China name: Huafang Li role: CONTACT lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06388538 id: Carlo Bergamini briefTitle: The COLD2B Multicenter, Two-arm Prospective Cohort Study acronym: COLD2B overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-05-01 date: 2025-06-01 date: 2024-04-29 date: 2024-04-29 name: Azienda Sanitaria di Firenze class: OTHER briefSummary: Since it is still debated whether 2b acute diverticulitis (AD), according to the World Society of Emergency Surgery (WSES) classification, should be initially treated surgically or conservatively, we launched the COLD2B study to compare the clinical results of both therapeutic regimens in a multi-institutional cohort of prospectively enrolled patients.
The second arm of the study will consider the population undergoing surgery, develop a model able to predict the length of hospitalization, and compare the open vs laparoscopic approach (primary end-point), and mortality, morbidity, and surgical outcome indices (secondary end-point). conditions: Acute Diverticulitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 500 type: ESTIMATED name: Conservative treatment (non-operative treatment) name: Surgical treatment (operative treatment) measure: Length of hospital stay in the overall population measure: Morbidity rate for both arms measure: Mortality rate for both arms measure: Surgical complications rate sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Dipartimento di Medicina di Precisione e Rigenerativa e Area Jonica (DiMePRe-J), Universita' di Bari city: Bari country: Italy name: Francesco Paolo Prete role: CONTACT lat: 41.11148 lon: 16.8554 facility: Department of Emergency and Acceptance, Emergency Surgery Unit, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy city: Florence zip: 50134 country: Italy name: Carlo Bergamini, MD role: CONTACT phone: +39(0)557949173 email: drcarlobergamini@gmail.com name: Carlo Bergamini role: PRINCIPAL_INVESTIGATOR name: Alessio Giordano role: PRINCIPAL_INVESTIGATOR lat: 43.77925 lon: 11.24626 facility: Department of Medicine, Surgery and Health Sciences, University of Trieste city: Trieste country: Italy name: Manuela Mastronardi role: CONTACT lat: 45.64953 lon: 13.77679 facility: Department of General Surgery, PO di Vittorio Veneto (TV), ULSS2 Marca Trevigiana city: Vittorio Veneto country: Italy name: Giulia Montori role: CONTACT lat: 45.98026 lon: 12.30065 hasResults: False
nctId: NCT06388525 id: PostERCPLC briefTitle: Post-ERCP Cholecystectomy. How ERCP and ERCP-related Variables Effect the Outcomes? overallStatus: COMPLETED date: 2016-01-01 date: 2020-01-01 date: 2020-01-01 date: 2024-04-29 date: 2024-04-29 name: Kanuni Sultan Suleyman Training and Research Hospital class: OTHER briefSummary: In this retrospective study, we aimed to detect of effects of ERCP on outcomes of Laparoscopic Cholecystectomy. Patients underwent elective cholecystectomy surgery with a diagnosis of symptomatic cholelithiasis were identified and divided into two main groups regarding to have a ERCP procedure prior to surgery or not. To eliminate possible differences in baseline characteristics, patients in ERCP and non-ERCP groups were propensity score-matched 1:1 using nearest-neighbor matching without replacement based on age, sex and ASA score. Following propensity score matching (PSM), the ERCP and non-ERCP groups were first compared to detect effects of the ERCP procedure itself. After comparison of two main groups, subgroup analyzes performed for the ERCP group to detect effect of ERCP-related variables (indication for ERCP procedure, time between last ERCP procedure and surgery, number of preoperative ERCPs, stone extractions, and biliary stent use) conditions: Endoscopic Retrograde Cholangiopancreatography conditions: ERCP-Laparoscopic Cholecystectomy Interval conditions: Number of Preoperative ERCPs conditions: Stone Extraction Status in ERCP Procedures conditions: Biliary Stents conditions: Mechanical Lithotripsy studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 426 type: ACTUAL name: Endoscopic Retrograde Cholangiopancreatography measure: Conversion to open measure: Subtotal Cholecystectomy measure: Postoperative Complications measure: Adhesion levels measure: Operative time measure: Length of hospital stay sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bakirkoy Dr. Sadi Konuk Training and Research Hospital city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06388512 id: STUDY00160044 briefTitle: iMRI Prone Positioning Frame Design Feasibility Study overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2024-12 date: 2024-04-29 date: 2024-04-29 name: University of Kansas Medical Center class: OTHER name: Continuum Educational Technologies briefSummary: The goal of this study is to learn if the prototype adjustable prone positioning frame is a feasible design for use during neurosurgical procedures which utilize intraoperative magnetic resonance imaging (iMRI). The main questions it aims to answer are:
* Does use of the prototype device place the patient at increased risk of complications compared to the standard positioning pads? Researchers will place patients in the prone position on the prototype device during neurosurgical procedures that utilize intraoperative MRI and observe for any problems with the positioning device or complications attributable to the positioning device. conditions: Epilepsy conditions: Pulmonary Embolism studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DEVICE_FEASIBILITY masking: NONE count: 5 type: ESTIMATED name: prototype prone positioning device measure: Number of devices that meet functional requirements measure: Number of devices that are damaged during use measure: Number of patients with skin complications measure: Number of patients with thromboembolic complications sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Kansas Medical Center city: Kansas City state: Kansas zip: 66160 country: United States name: Andrew Guillotte, MD role: CONTACT phone: 309-648-7036 email: aguillotte@kumc.edu name: Anand Dharia, MD role: SUB_INVESTIGATOR name: Jennifer Cheng, MD role: SUB_INVESTIGATOR name: Michael Kinsman, MD role: PRINCIPAL_INVESTIGATOR name: Christopher Miller, MD role: SUB_INVESTIGATOR lat: 39.11417 lon: -94.62746 hasResults: False
nctId: NCT06388499 id: GOIPG/2022/1854 briefTitle: A Physiotherapy-led Disease-agnostic Telerehabilitation Programme for People With Chronic Health Conditions overallStatus: RECRUITING date: 2024-04-16 date: 2024-07-22 date: 2024-07-31 date: 2024-04-29 date: 2024-04-29 name: University of Limerick class: OTHER briefSummary: This protocol outlines a planned mixed methods feasibility trial which will be conducted to examine the feasibility and acceptability of a physiotherapy-led exercise-based telerehabilitation programme for groups of people with mixed chronic health conditions. conditions: Chronic Conditions, Multiple studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: TECC (Telerehabilitation and Exercise for Chronic Conditions) measure: Recruitment rate assessed by number of participants recruited during recruitment period. measure: Retention rate assessed by the proportion of enrolled participants who complete post-intervention assessments. measure: Adherence rate assessed by the attendance at synchronous group exercise sessions measure: Satisfaction with the intervention as assessed by the Client-Satisfaction Questionnaire 8 (CSQ-8) measure: Satisfaction with individual intervention components assessed by Numerical Rating Scales (NRS) measure: Adverse events assessed via self-report questionnaire measure: Intervention acceptability as assessed by qualitative feedback from participants via focus groups measure: Physical function assessed by the 30-second chair stand test (30CST). measure: Quality of life assessed by the Euro-QoL 5 Dimension 5 Level (Euro-QoL-5D-5L). sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: South Tipperary Chronic Disease Management Hub, St. Brigid's Hospital, Carrick-on-Suir status: RECRUITING city: Tipperary country: Ireland name: Niamh Julian, BSc role: CONTACT lat: 52.47333 lon: -8.15583 hasResults: False
nctId: NCT06388486 id: UMCGoettingen9/9/16 briefTitle: Cytokine-Induced Transcription in Depressed Inpatients Undergoing Psychotherapy acronym: CitDip overallStatus: COMPLETED date: 2017-01-01 date: 2022-03-09 date: 2024-01-01 date: 2024-04-29 date: 2024-04-29 name: University Medical Center Goettingen class: OTHER briefSummary: The goal of this observational study is to measure the levels of cytokine-induced transcription factor activation in a cohort of depressed inpatients undergoing psychotherapy. The study aims to answer the following main questions:
Study subjects are assessed for their psychological and behavioral traits and receive psychotherapeutic care over several weeks during hospital treatment. Peripheral blood mononuclear cells are isolated from the study subjects, and activation of transcription factors is measured by flow cytometry. conditions: Depression studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 63 type: ACTUAL name: Psychotherapy measure: Change in depression sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06388473 id: NMRR-20-2188-56086 IIR briefTitle: Implementation of a Web-based App for Screening in Men in a Malaysian Primary Care Setting acronym: iScreenMen overallStatus: COMPLETED date: 2021-01-14 date: 2021-06-06 date: 2021-06-06 date: 2024-04-29 date: 2024-04-29 name: University of Malaya class: OTHER briefSummary: The purpose of this study is to determine how to successfully implement ScreenMen in the primary care setting. ScreenMen is a mobile web-based app that has been developed to increase the uptake of screening in men. ScreenMen undertook a vigorous and systematic approach in its development. It was developed based on theories, evidence and needs of men. ScreenMen particularly target men in the age group of 20 to 50 years as this group of men usually do not attend any health screening. This research is necessary because ScreenMen has yet to be implemented in the primary care setting. The study will last about five months and your participation will be about five months. conditions: Men's Health Screening conditions: Implementation conditions: Web-based Application studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 101 type: ACTUAL name: Tailored implementation intervention measure: Reach measure: Reach measure: Adoption of ScreenMen using qualitative methods measure: Implementation of ScreenMen using qualitative methods measure: Maintenance of ScreenMen using qualitative methods measure: Impact of COVID-19 on the clinic using qualitative methods sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Klinik Kesihatan Cheras Baru city: Kuala Lumpur zip: 56100 country: Malaysia lat: 3.1412 lon: 101.68653 hasResults: False
nctId: NCT06388460 id: STUDY00001015 id: R01HL169229 type: NIH link: https://reporter.nih.gov/quickSearch/R01HL169229 briefTitle: Asthma Link Effectiveness Trial: Cluster Randomized Controlled Trial overallStatus: RECRUITING date: 2024-04-04 date: 2028-01 date: 2028-04 date: 2024-04-29 date: 2024-04-29 name: University of Massachusetts, Worcester class: OTHER name: National Institutes of Health (NIH) name: National Heart, Lung, and Blood Institute (NHLBI) briefSummary: The goal of this cluster RCT is to determine the effectiveness of Asthma Link, a school supervised asthma therapy program, compared with an educational asthma workbook, in improving asthma symptoms for children with poorly controlled asthma aged 5-14. conditions: Childhood Asthma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 350 type: ESTIMATED name: Asthma Link name: Enhanced Usual Care measure: Improving Asthma Symptoms measure: Improving Medication Adherence measure: Improving Healthcare Utilization measure: Reducing Parental Lost Workdays measure: Reducing School Absences measure: Improving Quality of Life sex: ALL minimumAge: 5 Years maximumAge: 14 Years stdAges: CHILD facility: University of Massachusetts Chan Medical School status: RECRUITING city: Worcester state: Massachusetts zip: 01655 country: United States name: Michelle Spano role: CONTACT phone: 508-856-2990 email: michelle.spano@umassmed.edu name: MIchelle Trivedi, MD MPH role: PRINCIPAL_INVESTIGATOR lat: 42.26259 lon: -71.80229 hasResults: False
nctId: NCT06388447 id: UCMSC1 briefTitle: Reconstruction of Deficient Interdental Papilla Using Stem Cells vs Physiological Saline: a RCT overallStatus: ENROLLING_BY_INVITATION date: 2023-12-01 date: 2024-12-31 date: 2025-03-30 date: 2024-04-29 date: 2024-04-29 name: University of Malaya class: OTHER briefSummary: The goal of this study is to assess the reconstruction of interdental papilla following the injection of UC-MSCs or physiological saline in patients with interdental papilla deficiency. Participants will be randomised into 2 groups (intervention vs placebo) to receive the treatment. conditions: Gingival Recession, Localized studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: Umbilical cord-mesenchymal stem cells measure: Reconstruction of the deficient interdental papilla with soft tissue measure: Reconstruction of the deficient interdental papilla with bone measure: Reconstruction of the deficient interdental papilla with bone sex: ALL minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Orthodontic Postgraduate Clinic city: Kuala Lumpur state: Wilayah Persekutuan Kuala Lumpur zip: 50603 country: Malaysia lat: 3.1412 lon: 101.68653 hasResults: False
nctId: NCT06388434 id: HP-00100309 briefTitle: Protective Arm Balance Responses acronym: PAT overallStatus: RECRUITING date: 2023-10-01 date: 2024-07 date: 2024-08 date: 2024-04-29 date: 2024-04-29 name: University of Maryland, Baltimore class: OTHER briefSummary: The overall objective of this study is to investigate the effect of attention control training on reach-grasp stabilizing responses during fall-induced perturbations. The central hypothesis is that training attention control during reach to grasp balance perturbations will lead to increased grasp accuracies and reduced in-task falls. This research will mark the first explore the effects of training attention control on protective arm responses and fall rate during a balance perturbation paradigm and the first feasibility testing of a fully integrated cognitive and physical rehabilitation paradigm, moving beyond correlative designs and parallel treatments. The overall public health significance of the proposed research is that with improved protective arm responses and grasp accuracies, a larger randomized control study may be designed to mitigate falls among community dwelling older adults.