hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06295341 id: 01C312 briefTitle: Short Stature and Psychological Well-being acronym: PSICOSHORT overallStatus: RECRUITING date: 2023-05-10 date: 2024-12-31 date: 2024-12-31 date: 2024-03-06 date: 2024-03-06 name: Istituto Auxologico Italiano class: OTHER briefSummary: The first aim of the present study is to evaluate the psychological impact of the condition of short stature (family) in a sample of Italian children, comparing them with subjects of normal stature, measuring their levels of psychological well-being, psychological distress, quality of health-related life and any behavioral issues. The secondary objective is to study the psychological impact evaluated with the tests described below (see methods section) in children with GH deficiency and the effects of replacement therapy (6 months) with GH from recombinant DNA. conditions: Short Stature conditions: Short; Stature, Psychosocial studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: OTHER count: 80 type: ESTIMATED name: Recombinant human growth hormone (only for children with growth hormone deficiency) measure: Psychological well-being through the Psychological Well-Being Scales (PWB) measure: Psychological distress through the Depression Anxiety Stress Scale (DASS-21) measure: Quality of life through the Quality of Life in Short Stature Youth (QoLISSY), measure: Skills and problems through the Strengths and Difficulties Questionnaire (SDQ) measure: Behavioral problems through the Child Behaviour Checklist for Children (CBCL) sex: ALL minimumAge: 6 Years maximumAge: 14 Years stdAges: CHILD facility: Istituto Auxologico Italiano status: RECRUITING city: Milano zip: 20145 country: Italy name: Alessandro Sartorio, MD role: CONTACT phone: +390261911 phoneExt: 2426 email: sartorio@auxologico.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06295328 id: NL 72439.018.19 briefTitle: From Fungus to Virus, Investigating the Safety and Efficacy of Terbinafine in Chronic Hepatitis B Patients acronym: HepBTer overallStatus: RECRUITING date: 2022-04-13 date: 2024-04-01 date: 2024-04-01 date: 2024-03-06 date: 2024-03-06 name: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) class: OTHER briefSummary: Rationale: Currently, there is no curative therapy available for patients that are chronically infected with the hepatitis B virus (HBV). Especially the presence of a viral reservoir of stable episomal, covalently closed circular DNA (cccDNA) in the nucleus of infected hepatocytes poses a great challenge for the development of curative therapies. HBV cccDNA acts as the template for production of viral proteins and HBV genomes. In a preclinical study, terbinafine (an antifungal agent) was identified as a potent and specific suppressor of HBx-mediated cccDNA transcription. HBx is an accessory viral protein of HBV which has been proven to be essential for HBV replication and enhances replication at the transcriptional level in vivo. The suppression of cccDNA transcription results in a strong reduction of the production of viral genomes (RNA and DNA) as well as viral proteins. This will allow recovery of the immune system, increase viral clearance and prevent replenishment of the cccDNA pool in the hepatocyte, all contributing to cure chronic hepatitis B (CHB).
Main study parameters/endpoints: Primary outcomes: decline in level of serum HBsAg \>0.32log10 IU/mL in both groups A and B and decline in serum HBV DNA \>0.86log10 in group A at the end of study treatment (week 10 vs baseline). Secondary outcomes: 1) Safety and tolerability of terbinafine as mono- or combination therapy; 2) level of serum HBsAg and HBV DNA at 3 months follow-up; 3) decline of HBsAg levels over time (all visits); 4) HBV RNA, large HBsAg (LHBs) HBcrAg levels, and HBeAg status at baseline and end of study 4).
Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Patients participating in this study will undergo physical examinations and blood sample collections (13 samples and in total 467.5 mL). They will also be asked to fill in the HBQOL and EQ5D5L quality of life questionnaires and a medicine diary. In total there will be 13 visits in the hospital of which 7 will be for blood collection only. Terbinafine can induce liver damage 1 of 50,000 to 120,000 prescriptions (LiverTox), a weekly safety laboratory control is implemented in the visits to detect possible liver toxicity in an early stage and prevent liver damage. conditions: Chronic Hepatitis b studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Phase 1b study with two parallel treatment arms and placebo controls. primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Double blind whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 36 type: ESTIMATED name: Terbinafine name: Placebo name: Tenofovir measure: Change in level of serum HBsAG measure: Change in serum HBV DNA measure: Safety of terbinafine measure: Tolerability of terbinafine measure: Serum levels of HBsAG measure: Serum levels of HBV DNA measure: Serum levels of HBV RNA measure: Serum levels of HBcrAg sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Amsterdam UMC status: RECRUITING city: Amsterdam state: Noord-Holland zip: 1105AZ country: Netherlands name: M.W. Peters, RN role: CONTACT phone: +31207320393 email: m.w.peters@amsterdamumc.nl name: D.J. van Doorn, MD role: SUB_INVESTIGATOR lat: 52.37403 lon: 4.88969 hasResults: False
nctId: NCT06295315 id: 01C310 briefTitle: Evaluation of the Psychological Profile of Adult Patients With Prader-Willi Syndrome acronym: PROPSICOPWS overallStatus: RECRUITING date: 2023-04-21 date: 2024-12-31 date: 2024-12-31 date: 2024-03-06 date: 2024-03-06 name: Istituto Auxologico Italiano class: OTHER briefSummary: The primary aim of the present study is to investigate the psychological profile of adult patients with PWS and the fatigue experienced by family members. Specifically, the level of psychological well-being, the subjective perception of life quality, and the main characteristics present in terms of psychopathological functioning of subjects with PWS will be investigated. These variables will be investigated in order to detect their presence and the main bonds of interaction, either between them or with other socio-demographic data, in a sample of adults with PWS. At the same time, the presence of psychological distress, levels of well-being quality of life, and coping strategies in family members and caregivers of individuals with PWS will be investigated. conditions: Prader-Willi Syndrome studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 36 type: ESTIMATED measure: Psychological well-being through the Psychological General Well-Being Index (PGWBI) measure: Perception of life quality through the 36-Item Short Form Survey (SF-36) measure: Mental distress through the Symptom Checklist-90-R (SCL-90-R) measure: Psychological distress through the Depression, Anxiety, and Stress Scale (DASS-21) measure: Coping strategies through Coping Orientation to Problem Experienced (COPE-new Italian version). measure: Hyperphagia of subjects with PWS through the Hyperphagia Questionnaire (HQ) sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Istituto Auxologico Italiano IRCCS, site Piancavallo status: RECRUITING city: Oggebbio state: Verbania zip: 28824 country: Italy name: Alessandro Sartorio, MD role: CONTACT phone: +390261911 phoneExt: 2426 email: sartorio@auxologico.it lat: 45.99088 lon: 8.64663 hasResults: False
nctId: NCT06295302 id: RFCU-IIa-202308 briefTitle: A Study to Explore the Efficacy and Safety of HWH486 in Adults With Chronic Spontaneous Urticaria overallStatus: RECRUITING date: 2023-12-13 date: 2025-12 date: 2026-01 date: 2024-03-06 date: 2024-03-07 name: Hubei Biological Medicine Industrial Technology Institute Co., Ltd. class: OTHER briefSummary: This is a multicenter, randomized, double-bind and placebo-controlled phase IIa dose-finding study to assess the safety and efficacy of HWH486 in adults with chronic spontaneous urticaria (CSU). In addition, the pharmacokinetic characteristics will also be investigated. conditions: Chronic Spontaneous Urticaria studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: HWH486 name: Placebo measure: Change in Urticaria Activity Score (UAS) over a 7-day period (UAS7) measure: Change in Hive Severity Score (HSS) over a 7-day period (HSS7) measure: Change in Itch Severity Score (ISS) over a 7-day period (ISS7) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: West China Hospital,Sichuan University status: RECRUITING city: Chengdu state: Sichuan country: China name: Bioethics Committee of West China Hospital role: CONTACT phone: +86 28 8512 3237 lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06295289 id: ZRKY-2023-04 briefTitle: Hybrid Closed-loop Insulin Delivery System in Perioperative Diabetic Patients: an Open-label, Randomized Controlled Trial overallStatus: RECRUITING date: 2023-10-16 date: 2024-10-04 date: 2024-12-04 date: 2024-03-06 date: 2024-03-06 name: Huazhong University of Science and Technology class: OTHER briefSummary: Perioperative management of glucose levels remains challenging. The purpose of the study is to compare the hybrid closed-loop insulin delivery system with the standard insulin therapy ( insulin pump with CGM, insulin dose controlled by physicians) in controlling glucose levels among patients in the perioperative period. conditions: Diabetes Mellitus studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 54 type: ESTIMATED name: Hybrid Closed-loop Insulin Delivery System name: Insulin pump measure: TIR measure: TAR measure: TBR measure: MBG measure: postoperative infection sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tongji Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology status: RECRUITING city: Wuhan state: Hubei zip: 430030 country: China name: Xuefeng Yu role: CONTACT phone: 02783662883 email: xfyu188@163.com lat: 30.58333 lon: 114.26667 hasResults: False
nctId: NCT06295276 id: HSOsnabruck briefTitle: Effect of Teletherapy-supported Training on Nursing Students overallStatus: RECRUITING date: 2024-01-31 date: 2024-12-31 date: 2024-12-31 date: 2024-03-06 date: 2024-03-06 name: Hochschule Osnabruck class: OTHER briefSummary: Design: This study is a pilot randomized controlled trial (RCT) with two-arm parallel groups, the gold standard for determining treatment efficacy. The flowchart (see appendix) provides an overview of the study design. Participants are randomized and stratified by age into intervention group and waiting list group.
The duration of the intervention is six weeks in total. At the beginning Neck Disability Index (NDI), Oswestry Disability Index (ODI), Short-Form-36 (SF36), and the Numerical rating Scale (NRS) are collected. After six weeks, the same outcome measures and the global rating scale conditions: Low Back Pain conditions: Neck Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Parallel comparative randomized controlled trial primaryPurpose: TREATMENT masking: NONE maskingDescription: Allocation concealment:
The results of the allocation sequence are placed in sequentially numbered, opaque, and sealed envelopes by an independent researcher to ensure confidentiality. count: 40 type: ESTIMATED name: teletherapy-guided exercise programme name: Waiting list/control intervention measure: Neck Disability Index (NDI) measure: Oswestry Disability Index (ODI) measure: NRS Numeric rating scale for pain measure: Short-Form: SF 36-Quality of life measure: Global rating scale sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Diakonie Pflege Schule status: RECRUITING city: Osnabrück state: Niedersachsen zip: 49078 country: Germany name: Roland Simon, BScPTc role: CONTACT phone: 05068932755 email: helmut.simon@hs-osnabrueck.de lat: 52.27264 lon: 8.0498 hasResults: False
nctId: NCT06295263 id: KYLL-202203-028-1 briefTitle: Application of AI Technology for the Diagnosis and Treatment of Geriatric Diseases overallStatus: RECRUITING date: 2022-03-01 date: 2026-06-28 date: 2026-06-29 date: 2024-03-06 date: 2024-03-15 name: Qilu Hospital of Shandong University class: OTHER name: Shandong University briefSummary: 1) Characteristics of handwriting, gait, speech, eye movements, biological samples (blood, urine, stool, saliva, etc.), images, EEG, and other relevant markers in patients with Alzheimer's disease.
(4) Characteristics of handwriting, gait, language, eye movement, biological samples (blood, urine, stool, saliva, etc.), images, EEG and other relevant markers in elderly patients. conditions: Parkinson Disease conditions: Alzheimer Disease conditions: Nervous System Diseases conditions: Geriatric Diseases studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 460 type: ESTIMATED name: Handwriting, gait, speech, eye movements, biological samples (blood, urine, stool, saliva, etc.), images, EEG, and other relevant markers measure: Handwriting measure: gait measure: speech measure: eye movements measure: biological samples (blood, urine, stool, saliva, etc.) measure: images measure: EEG measure: other relevant markers sex: ALL minimumAge: 8 Years maximumAge: 100 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Qilu Hospital of Shandong University status: RECRUITING city: Jinan state: Shandong zip: 250012 country: China name: Wenjing Jiang role: CONTACT phone: 18560082210 email: jiangwenjing@qiluhospital.com lat: 36.66833 lon: 116.99722 hasResults: False
nctId: NCT06295250 id: STUDY00001114 id: 7R01MH127577 type: NIH link: https://reporter.nih.gov/quickSearch/7R01MH127577 briefTitle: ASHA Bangladesh--Integrated Intervention to Address Poverty and Depression overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2027-12-30 date: 2027-12-30 date: 2024-03-06 date: 2024-03-06 name: University of Massachusetts, Worcester class: OTHER name: International Centre for Diarrhoeal Disease Research, Bangladesh name: Georgetown University name: National Institute of Mental Health (NIMH) name: Albert Einstein College of Medicine briefSummary: The goal of this randomized controlled trial is to compare the impact of an integrated intervention combining poverty alleviation and depression treatment to depression treatment alone, in low income rural Bangladeshi women with depression. The main question\[s\] it aims to answer are: 1) whether adding poverty alleviation to depression treatment in an integrated intervention improves depression outcomes at 24 months, as assessed by depressive symptoms and by the presence or absence of relapse; and 2) whether adding poverty alleviation to depression treatment improves implementation outcomes including treatment uptake and retention. Participants in both arms will participate in interviews at 6,12,18 and 24 months. conditions: Depression conditions: Economic Vulnerability studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Interventionists and outcome assessors will not be informed regarding the study design and research question. whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 660 type: ESTIMATED name: Manualized Group Based Psychotherapy name: Poverty Alleviation measure: Change in Depressive symptoms at 24 Months measure: Change in Depressive symptoms at intermediate timepoints measure: 24 Month Relapse measure: Economic vulnerability measure: Anxiety measure: Function measure: European Quality of Life Five Dimensions Five Level scale measure: Tension Scale measure: Implementation Outcomes--Adoption measure: Implementation Outcomes--Feasibility measure: Implementation outcomes--fidelity sex: FEMALE minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: International Centre for Diarrhoeal Disease Research city: Dhaka country: Bangladesh name: Fahmida Tofail, MBBS, PhD role: CONTACT email: ftofail@icddrb.org lat: 23.7104 lon: 90.40744 hasResults: False
nctId: NCT06295237 id: i-Sync briefTitle: Automatic Adjustment for Asynchronies During Mechanical Ventilation acronym: i-Sync overallStatus: RECRUITING date: 2024-02-15 date: 2025-02-15 date: 2025-07-01 date: 2024-03-06 date: 2024-03-08 name: Hospital San Carlos, Madrid class: OTHER name: Fundación de Investigación Biomédica - Hospital Universitario de La Princesa briefSummary: Asynchronies between the patient and the artificial ventilator are a frequent problem. They may cause altered sleep, ventilator-induced lung injury, prolong length of ICU stay, cause neuro-psycologic complications and increase mortality. Although reducing their incidence through ventilator setting adjustments is possible, they frequently go undetected and it also requires that attendings remain at the bedside to repeatedly modify ventilator parameters. Ventilator systems may detect and automatically adjust parameters of mechanical ventilation. This would avoid delays in detection and adjustment if the intensivist is not immediately available. The investigators intend to study an automatic detection and adjustment tool which is incorporated in the ventilator software. conditions: Mechanical Ventilation Complication studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Two 2-hour periods: 1) "off mode" consisting of a control period with optimized ventilator parameters and 2) "on mode" with an active automated detection and adjustment for asynchronies. The starting first period is randomized. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Anonymized evaluation whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Intellisync+ measure: Duration of asyncronies sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Clinico San Carlos status: RECRUITING city: Madrid zip: 28040 country: Spain name: Miguel Sanchez-Garcia, MD role: CONTACT phone: +34658762739 email: miguelsanchez.hcsc@gmail.com name: Paloma Gonzalez-Arenas, MD role: CONTACT phone: +34 670 57 66 45 email: pgarenas@gmail.com name: David Janeiro Lumbreras, MD role: SUB_INVESTIGATOR name: Fernando Suarez-Sipmann, MD role: PRINCIPAL_INVESTIGATOR name: José Antonio Sánchez-Giralt, MD role: SUB_INVESTIGATOR lat: 40.4165 lon: -3.70256 hasResults: False
nctId: NCT06295224 id: GOKAEK-2024/02.19 briefTitle: Retrospective Evaluation of Effect of Anterior Iliac Block overallStatus: RECRUITING date: 2024-01-01 date: 2024-03-10 date: 2024-03-15 date: 2024-03-06 date: 2024-03-06 name: Kocaeli University class: OTHER briefSummary: In this study, the investigators aimed to evaluate the effect of ultrasound-guided anterior iliac block which was performed preoperatively. Anterior iliac bone harvesting is associated with severe postoperative pain. As several fascial plane blocks were defined to provide analgesia, their effects are debatable and requires high volumes of local anesthetic considering the regional anesthesia technique used for the main surgical procedure. conditions: Regional Anesthesia studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 14 type: ESTIMATED measure: Morphine consumption measure: NRS score sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kocaeli Universty status: RECRUITING city: Kocaeli country: Turkey name: Hadi Ufuk Yörükoğlu role: CONTACT email: ufukyorukoglu@gmail.com lat: 39.62497 lon: 27.51145 hasResults: False
nctId: NCT06295211 id: FEDII_HL_PR/R-Bv-Bs briefTitle: Brentuximab Vedotin Combined With Bendamustine Supercharge, a Low-toxicity and Efficient Salvage Regimen for Primary Refractory or First-relapsed Classic Hodgkin Lymphoma: Long-term Results of a Retrospective Monocenter Study. acronym: HL_PR/R-B overallStatus: COMPLETED date: 2013-09-01 date: 2023-09-01 date: 2024-02-22 date: 2024-03-06 date: 2024-03-06 name: Federico II University class: OTHER briefSummary: This is a retrospective, monocenter and non-interventional study. Data were retrospectively collected from all patients who completed the BV-Bs scheme in the time period between 1 September 2013 and 1 September 2023. conditions: Hodgkin Lymphoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 32 type: ACTUAL name: observational measure: Overall survival measure: Progression overall survival measure: Response to treatment measure: Incidence of treatment emergent adverse events sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
nctId: NCT06295198 id: OPMM-Ankle Instability briefTitle: The Effect of Different Talocrural Joint Mobilization Techniques in Lateral Ankle Sprain overallStatus: RECRUITING date: 2023-07-30 date: 2024-03-01 date: 2024-03-30 date: 2024-03-06 date: 2024-03-08 name: Bahçeşehir University class: OTHER briefSummary: Decreased ankle dorsiflexion range of motion (DFROM) has been identified among the factors that increase the risk of lateral ankle sprain (LAS) in basketball players. Restoring the DFROM is important in restoring reduced functional abilities and reducing the risk of re-injury. There is evidence that talocrural joint mobilization improves DFROM, but studies investigating the effectiveness of different mobilization techniques are needed. Our study aims to investigate the effects of single-session Mulligan and Maitland talocrural joint mobilization methods on dorsiflexion joint range of motion, jumping performance, and kinesiophobia in elite basketball players. conditions: Ankle Sprains conditions: Ankle Injuries conditions: Kinesiophobia conditions: Jumping From Height studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants with lateral ankle sprains will be randomized to the Mulligan and Maithland groups, and their evaluations and treatments will be completed. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: After evaluations, the groups determined as a result of randomization via a website were placed in opaque envelopes. The participant is randomized to one of the Mulligan or Maitland groups by selecting an envelope. whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Single lep drop jump test measure: Single-leg drop jump test measure: Weight-bearing lunge test measure: Tampa kinesiophobia scale measure: Fear Avoidance Belief Questionnaire sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Bahcesehir University status: RECRUITING city: Besiktas state: Istanbul zip: 34353 country: Turkey name: Pelin Pişirici, PT, PhD role: CONTACT phone: 05055016076 email: pelinpisirici@gmail.com name: Ozlem Feyzioglu, PT, PhD role: CONTACT phone: 05353529794 email: fztozlemfeyzioglu@gmail.com hasResults: False