hackint0sh/New-Dataset huggingface dataset:
2. Controlled Cohort (next 30 participants) - participants randomized 1:1 (equal chance) to start treatment with Epidiolex (cannabidiol) or placebo for 16 weeks, followed by an 8-week washout period (no treatment). Participants then switch to the opposite treatment group for 16 weeks followed by all participants treated for 52 weeks with Epidiolex (cannabidiol). conditions: Sanfilippo Syndrome conditions: Mucopolysaccharidosis III studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Double-blind, placebo-controlled, cross-over study primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 35 type: ESTIMATED name: Epidiolex name: Placebo measure: Sanfilippo Behavior Rating Scale (SBRS)- mood/anger/aggression score sex: ALL minimumAge: 4 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center city: Torrance state: California zip: 90502 country: United States name: Cristi Williams role: CONTACT email: cristi.williams@lundquist.org name: Lynda Polgreen, MD, MS role: PRINCIPAL_INVESTIGATOR lat: 33.83585 lon: -118.34063 hasResults: False
nctId: NCT06333028 id: 938 briefTitle: A Study to Evaluate the enVista® Aspire (EA) Intraocular Lens in Subjects Undergoing Cataract Extraction overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-09 date: 2024-09 date: 2024-03-27 date: 2024-04-29 name: Bausch & Lomb Incorporated class: INDUSTRY briefSummary: A Study to Evaluate the enVista® Aspire (EA) intraocular lens in Subjects Undergoing Cataract Extraction conditions: Cataract studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: enVista Aspire EA IOLs measure: Mean binocular BCDVA (logMAR) at Visit 1 sex: ALL minimumAge: 22 Years stdAges: ADULT stdAges: OLDER_ADULT facility: SITE 104 city: Dover state: New Jersey zip: 07801 country: United States lat: 40.88399 lon: -74.5621 facility: Site 105 city: Woodland Park state: New Jersey zip: 07424 country: United States lat: 40.88982 lon: -74.19487 facility: Site 103 city: Garden City state: New York zip: 11530 country: United States lat: 40.72677 lon: -73.6343 facility: Site 106 city: Charleston state: South Carolina zip: 29407 country: United States lat: 32.77657 lon: -79.93092 facility: Site 101 city: Sugar Land state: Texas zip: 77478 country: United States lat: 29.61968 lon: -95.63495 facility: Site 102 city: Mount Pleasant state: Wisconsin zip: 53405 country: United States lat: 42.69743 lon: -87.85577 hasResults: False
nctId: NCT06333002 id: PI24/00325 briefTitle: Machine Learning Model to Predict Outcome and Duration of Mechanical Ventilation in Acute Hypoxemic Respiratory Failure acronym: MEMORIAL overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-19 date: 2026-05-30 date: 2026-05-30 date: 2024-03-27 date: 2024-03-27 name: Dr. Negrin University Hospital class: OTHER briefSummary: Acute hypoxemic respiratory failure (AHRF) is the most common cause of admission in the intensive care units (UCIs) worldwide. We will assess the value of machine learning (ML) techniques for early prediction of ICU death and prolonged duration (\>7 days) of mechanical ventilation (MV) in 1,241 patients enrolled in the PANDORA (Prevalence AND Outcome of acute Respiratory fAilure) Study in Spain. The study was registered with ClinicalTrials.gov (NCT03145974). Our aim is to evaluate the minimum number of variables models using logistic regression and four supervised ML algorithms: Random Forest, Extreme Gradient Boosting, Support Vector Machine and Multilayer Perceptron. conditions: Acute Hypoxemic Respiratory Failure studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1241 type: ESTIMATED name: machine learning analysis measure: ICU mortality measure: MV duration sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital General Universitario de Ciudad Real city: Ciudad Real zip: 13005 country: Spain lat: 38.98626 lon: -3.92907 facility: Hospital Virgen de La Luz city: Cuenca zip: 16002 country: Spain lat: 40.06667 lon: -2.13333 facility: Hospital Universitario La Paz city: Madrid zip: 28046 country: Spain lat: 40.4165 lon: -3.70256 facility: Hospital Universitario Puerta de Hierro city: Madrid zip: 28222 country: Spain lat: 40.4165 lon: -3.70256 facility: Hospital Universitario Virgen de Arrixaca city: Murcia zip: 3012 country: Spain lat: 37.98704 lon: -1.13004 facility: Hospital Universitario NS de Candelaria city: Santa Cruz De Tenerife zip: 38010 country: Spain lat: 28.46824 lon: -16.25462 facility: Hospital Cinico de Valencia city: Valencia zip: 46010 country: Spain lat: 39.46975 lon: -0.37739 facility: Hospital Universitario Rio Hortega city: Valladolid zip: 47012 country: Spain lat: 41.65518 lon: -4.72372 hasResults: False
nctId: NCT06332989 id: N22.129 briefTitle: Stroke Triage Optimization by Ambulance Paramedics in the Pre-hospital Setting acronym: STROKE-APP overallStatus: RECRUITING date: 2024-02-01 date: 2027-02-01 date: 2027-02-01 date: 2024-03-27 date: 2024-03-27 name: Leiden University Medical Center class: OTHER name: Alrijne Ziekenhuis Leiderdorp name: Groene Hart Ziekenhuis name: Medical Center Haaglanden name: HagaZiekenhuis name: Reinier de Graaf Groep name: Regionale Ambulance Voorziening Hollands Midden briefSummary: There are everal scales designed to help ambulance paramedics to identify a patient with a stroke and activate a stroke code. These scales were never tested in the field in a large unselected patient sample. We aim to perform an in-the field head tot head comparison of all published stroke scales designed to be used by ambulance paramedics conditions: Stroke, Acute conditions: Pre-hospital Triage conditions: Stroke Treatment conditions: Stroke Code studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 3000 type: ESTIMATED name: stroke-APP measure: final diagnosis measure: treated with reperfusion therapy measure: additional investigations sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Leiden University medical center status: RECRUITING city: Leiden country: Netherlands name: Nyika D Kruyt, MD. PhD role: CONTACT phone: 0031-715262139 email: n.d.kruyt@lumc.nl lat: 52.15833 lon: 4.49306 hasResults: False
nctId: NCT06332976 id: IEO 1521 briefTitle: PrefeRences And ChemoTherapy In Breast Cancer patiEnts acronym: PRACTICE overallStatus: RECRUITING date: 2021-06-04 date: 2024-12-31 date: 2024-12-31 date: 2024-03-27 date: 2024-03-27 name: European Institute of Oncology class: OTHER briefSummary: The aim of the present study is to ask women treated with adjuvant or neoadjuvant chemotherapy for breast cancer what survival benefit would justify the treatment.
3. after the end of chemotherapy conditions: Female Breast Cancer studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 450 type: ESTIMATED name: Completion of questionnaires measure: Percentage of risk reduction needed to consider adjuvant or neoadjuvant chemotherapy worthwhile measure: Prolonged survival time gain needed to consider CT worthwhile measure: Behavior assessment measure: Reaction to uncertain situations assessment measure: Regret and disappointment assessment sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: European Institute of Oncology status: RECRUITING city: Milan zip: 20141 country: Italy name: Emilia Montagna, MD role: CONTACT phone: +390257489970 email: emilia.montagna@ieo.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06332950 id: MA-SCLC-II-015 briefTitle: Safety and Efficacy of Adebrelimab Plus Irinotecan Liposome (II) With or Without Famitinib in ES-SCLC Pre-treated With Immunotherapy overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-04-01 date: 2027-04-01 date: 2024-03-27 date: 2024-03-27 name: Baohui Han class: OTHER briefSummary: This is an open-label, randomized, multi-cohort, multi-center, phase Ib/II study to evaluate the safety and efficacy of Adebrelimab plus Irinotecan Liposome (II) with or without Famitinib in patients with extensive-stage small cell lung cancer (ES-SCLC) pre-treated with immune checkpoint inhibitor(s). conditions: Extensive-stage Small-cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 80 type: ESTIMATED name: Adebrelimab, Irinotecan Liposome (II) name: Adebrelimab, Irinotecan Liposome (II), Famitinib measure: 6-month progression-free survival measure: Safety measure: Objective response rate measure: Progression-free survival measure: Overall survival measure: Disease control rate measure: Duration of response sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai Chest Hospital city: Shanghai country: China name: Baohui Han, M.D role: CONTACT email: 18930858216@163.com lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06332937 id: H-2102-079-1197 briefTitle: Breast Reconstruction overallStatus: ACTIVE_NOT_RECRUITING date: 2021-02-22 date: 2023-12-15 date: 2024-12-31 date: 2024-03-27 date: 2024-03-27 name: Seoul National University Hospital class: OTHER briefSummary: Complications following postmastectomy breast reconstruction can compromise surgical outcomes and lead to significant morbidity. The aim of this study was to determine factors associated with complication following two-stage implant-based reconstruction conditions: Breast Implant; Complications studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 5000 type: ESTIMATED name: postmastectomy breast reconstruction measure: Infection sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Seoul National University Hospital city: Seoul zip: 03080 country: Korea, Republic of lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06332924 id: 2023/19 briefTitle: Primipara Pregnant Women and Motivational Interview overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-07-01 date: 2024-08-01 date: 2024-03-27 date: 2024-03-27 name: Saglik Bilimleri Universitesi class: OTHER briefSummary: The first birth is the most important moment a woman experiences in her life as she embarks on her motherhood journey. Waiting for the birth of a new life can be very exciting for mothers. Positive birth is an approach that asks the woman to approach her birth story from a positive perspective and to have a stronger, more impressive and positive birth experience. Primipara pregnant women especially benefit from and need this positive birth approach. Motivational interviews are interviews conducted to support positive births and to help women develop a positive attitude towards their birth experiences.
This planned study was planned as a randomized controlled trial with pre-test and post-test measurements, with the aim of determining the level of traumatic birth perception in primipara women who were given or not given training and examining the effects of positive birth motivational education by taking into account the need for education with numerical data. conditions: Pregnancy Related studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: In the project, it was calculated that the experimental and control groups should have at least 30 observations each, and the sample of the study was calculated as 60 pregnant women. It was aimed to interview a total of 60 pregnant women, 30 in the control group and 30 in the experimental group. primaryPurpose: PREVENTION masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: motivational discussion group measure: Primipara Pregnant Women and Traumatic Birth sex: FEMALE minimumAge: 20 Years maximumAge: 35 Years stdAges: ADULT hasResults: False
nctId: NCT06332911 id: RO-231129 briefTitle: Shockwave™Peripheral Intravascular Lithotripsy Balloon for Advanced Endovascular Aortic Repair acronym: TEVAR overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2025-08-30 date: 2026-08-30 date: 2024-03-27 date: 2024-03-27 name: Rede Optimus Hospitalar SA class: NETWORK name: Shockwave Medical, Inc. briefSummary: Shockwave TEVAR is a nonrandomized, prospective, international, multi-center, PMCF, obervational study.
The aim of this study is to evaluate the outcomes of the Shockwave™ Peripheral Intravascular Lithotripsy Balloon (Shockwave Medical Inc.) in the routine treatment of hostile iliac accesses during TEVAR and F/BEVAR. conditions: Thoracoabdominal Aortic Aneurysm, Without Mention of Rupture conditions: Abdominal Aortic Aneurysm Without Rupture conditions: Thoracic Aortic Aneurysm Without Rupture studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 30 type: ESTIMATED name: Shockwave™ Peripheral Intravascular Lithotripsy Balloon M5+ measure: Efficacy: Technical success - defined as intention-to-treat basis sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06332898 id: AG-01-0324 briefTitle: The Effects of a Nutritional Supplement on Nutrient Status and Quality of Life overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2024-10-31 date: 2025-02-04 date: 2024-03-27 date: 2024-04-01 name: Athletic Greens International class: INDUSTRY name: Citruslabs briefSummary: This study is a randomized, double-blind, placebo-controlled study of N=120 apparently healthy men and women. The purpose of this study is to assess the effect of a novel dietary supplement on blood markers of nutrient status, gut microbiome, and overall quality of life. conditions: Nutrition, Healthy conditions: Gastrointestinal Microbiome conditions: Healthy Aging studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized, Double-Blind, Placebo Controlled Design primaryPurpose: OTHER masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: AG1 - Nutritional Supplement name: Placebo measure: Homocysteine measure: Vitamin B12 measure: Folate measure: Red Blood Cell Folate measure: Zinc measure: Vitamin C measure: Gut Microbiome measure: Dietary habits measure: Gastrointestinal Health measure: Fatigue & energy measure: Well-being measure: Complete Metabolic Blood Panel measure: Complete Blood Count sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
nctId: NCT06332872 id: M046q/66 briefTitle: Comparison Effectiveness of Oral Ivermectin , 1% Permethrin Shampoo and 4% Dimeticone Liquid Gel in the Treatment of Pediculosis Capitis Among School Children in Chachoengsao Province, Thailand overallStatus: ACTIVE_NOT_RECRUITING date: 2023-12-15 date: 2024-03-18 date: 2024-05 date: 2024-03-27 date: 2024-03-27 name: Phramongkutklao College of Medicine and Hospital class: OTHER briefSummary: The goal of this clinical trial is to Comparison effectiveness of Oral ivermectin , 1% Permethrin shampoo and 4% Dimeticone liquid gel in the treatment of Pediculosis capitis, to assess the prevalence of lice and associated risk factors between severity groups by using questionnaire-based surveys and diagnostic tests among school children in Baan Nayao, Chachoengsao Province, Thailand.
Participants voluntarily received oral ivermectin as per medical prescription, with treatment outcomes, side effects, and satisfaction levels monitored following two treatment cycles. Those exhibiting persistent lice infestations were subsequently treated with 1% permethrin shampoo, the standard treatment, while alternatives were provided for individuals allergic to permethrin. These findings will contribute to formulating tailored, effective, and safe treatment regimens for future patients. conditions: Pediculus Capitis Infestation conditions: Permethrin Adverse Reaction conditions: Dimethicone Adverse Reaction conditions: Permethrin Allergy conditions: Dimethicone Allergy conditions: Ivermectin conditions: School-age Children studyType: INTERVENTIONAL phases: PHASE4 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 117 type: ESTIMATED name: Oral Ivermectin name: 4% dimenticone liquid gel measure: Comparison effectiveness of Oral ivermectin , 1% Permethrin shampoo and 4% Dimeticone liquid gel in the treatment of Pediculosis capitis measure: Prevalence of head louse infestation among school children in Chachoengsao Province, Thailand measure: Side effects of Oral ivermectin , 1% Permethrin shampoo and 4%Dimeticone liquid gel measure: The association factor of head lice infestation among school children in Chachoengsao Province, Thailand sex: ALL minimumAge: 6 Years maximumAge: 13 Years stdAges: CHILD facility: Phramongkutklao college of medicine city: Bangkok country: Thailand lat: 13.75398 lon: 100.50144 hasResults: False
nctId: NCT06332859 id: FOR-0022 briefTitle: Effectiveness of a Resilience-Based Rehabilitation Program for Patients With Coronary Heart Disease overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-10-14 date: 2026-10-14 date: 2024-03-27 date: 2024-03-27 name: Pensionsversicherungsanstalt class: OTHER briefSummary: To handle daily life challenges, one needs to be psychologically resilient. It plays a crucial role in disease development, prognosis, as well as social, occupational, and community participation. Cardiovascular diseases cause physical and psychological stress, which can be linked to individual resilience and the development of such diseases. Stress can trigger TakoTsubo cardiomyopathy and acute coronary events. Individuals who have experienced TakoTsubo cardiomyopathy or an acute coronary event often feel stressed due to emotional or physical triggers. These triggers may include job loss or illness. In medical rehabilitation, therapists consider the individual circumstances of their patients when planning therapy. It may be important to add a special focus on psychological care, including building resilience, which could greatly benefit these individuals. Therefore, the study aims to investigate whether resilience training, as part of an inpatient multidisciplinary rehabilitation program, affects the individual resilience of rehabilitants with TakoTsubo cardiomyopathy or those who have experienced an acute coronary event. conditions: Takotsubo Cardiomyopathy conditions: Acute Coronary Syndrome conditions: Psychological Resilience studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 130 type: ESTIMATED name: Resilience training measure: Resilience scale-13 (RS-13) measure: Brief Resilience scale - German Version (BRS) measure: European Quality of Life 5 Dimensions 5 Level (EQ-5D-5L) measure: Patient Health Questionnaire-4 (PHQ-4) measure: Maximal incremental exercise test measure: Work ability index (WAI) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06332846 id: KB-0012/06/10 briefTitle: Oral Health in Patients Hospitalized Because of Ischemic Stroke overallStatus: COMPLETED date: 2019-10-10 date: 2021-11-15 date: 2023-12-10 date: 2024-03-27 date: 2024-03-27 name: Pomeranian Medical University Szczecin class: OTHER briefSummary: Maintaining good oral health is essential for general health and quality of life. Results of many anal-yses showed that stroke patients had poorer oral condition and worse periodontal status than control population. The aim of the study was to carry out a clinical observation concerning condition of oral health in stroke patients and healthy population.
The oral health was assessed in patients with stroke and in (control group). The following elements were assessed: missing teeth, the presence of active caries foci, the presence of existing fillings and prosthetic restorations. To assess oral hygiene API (Approximal Plaque Index) was used. As part of periodontal examina-tion, the following were assessed: the presence of dental deposits, the depth of the existing periodontal pockets, tooth mobility according to Hall and Sulcus Bleeding Index during probing (SBI). conditions: Oral Disease conditions: Stroke, Ischemic studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 118 type: ACTUAL name: oral examination name: oral examination measure: Oral health status measure: Oral hygiene assessment measure: Periodontal status- periodontal pockets measure: Periodontal status-tooth mobility measure: Periodontal status- bleeding sex: ALL minimumAge: 45 Years maximumAge: 89 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pomeranian Medical University in Szczecin city: Szczecin zip: 70-111 country: Poland lat: 53.42894 lon: 14.55302 hasResults: False
nctId: NCT06332833 id: 235 briefTitle: Availability of Venous Conduits in Patients With Varicose Veins for Arterial Bypass Surgery overallStatus: RECRUITING date: 2023-12-01 date: 2024-05-31 date: 2024-05-31 date: 2024-03-27 date: 2024-03-27 name: Pirogov Russian National Research Medical University class: OTHER briefSummary: Patients with PAD having superficial femoral artery (SFA) occlusion were consecutively enrolled. Demographic data and medical history were taken. Physical examination and duplex ultrasound were performed. conditions: Varicose Veins conditions: Peripheral Arterial Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 80 type: ESTIMATED measure: availability of saphenous trunks as possible grafts measure: presence of varicose veins measure: type of previous invasive procedure sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Veronika Golovina status: RECRUITING city: Moscow state: Pirogov Russian National Research Medical University zip: 109044 country: Russian Federation name: Veronika Golovina, MD, PHD role: CONTACT phone: +79776051708 email: nikuskin@inbox.ru lat: 55.75222 lon: 37.61556 hasResults: False