hackint0sh/New-Dataset huggingface dataset:
Participants will receive a weekly infusion in their vein of allopregnanolone for a total of 12 weeks. There is no placebo so everyone receives allopregnanolone and "Open-label" means the study is not blinded so both the participant and investigators know the assigned treatment. conditions: Parkinson Disease studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: Allopregnanolone measure: Study completion measure: Adverse Events measure: Infusion Reactions measure: Pharmacokinetics: Peak Plasma Concentration (Cmax) measure: Pharmacokinetics: Time of peak concentration (tmax) measure: Pharmacokinetics: Half-life (t1/2) measure: Pharmacokinetics: Area under the plasma concentration versus time curve (AUC) measure: Dopamine transporter (DaT) SPECT imaging measure: MRI: Regional brain volumes measure: MRI: Fractional Anisotropy measure: MRI: Quantitative anisotropy measure: MRI: Functional connectivity measure: Mean rate of change in the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) score part I (non-motor EDL) measure: Mean rate of change in the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) score part II (motor EDL) measure: Mean rate of change in the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) score part III (motor examination) measure: Mean rate of change in the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) score part IV (motor complications) measure: Mean rate of change in the Unified Dyskinesia Rating Scale (UDysRS) total score measure: Change from baseline in Montreal Cognitive Assessment (MoCA) score measure: Change from baseline in Parkinson's disease Questionnaire (PDQ-39). measure: Change from baseline in Hamilton Depression Rating Scale (HAM-D) measure: Cambridge Cognition's Paired Associates Learning (PAL) Test measure: Cambridge Cognition's Motor Screening Task (MOT) measure: Cambridge Cognition's One Touch Stockings of Cambridge (OTS) sex: ALL minimumAge: 40 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The University of Arizona Clinical & Translational Science Research Center status: RECRUITING city: Tucson state: Arizona zip: 85721 country: United States name: Dakota Darby role: CONTACT email: dakotadarby@arizona.edu lat: 32.22174 lon: -110.92648 hasResults: False
nctId: NCT06262997 id: TU-FTR-AMUTLU-2 briefTitle: Effectiveness of Pilates and Taping in Office Workers With Neck Pain overallStatus: RECRUITING date: 2024-02-15 date: 2025-02-15 date: 2025-02-15 date: 2024-02-16 date: 2024-02-23 name: Tarsus University class: OTHER briefSummary: The aim of this study is to investigate the effectiveness of pilates and kinesiotape applications in office workers with neck pain. In this direction, neck pain and disability, pain threshold, muscle strength, range of motion, core endurance, postural awareness and quality of life will be evaluated. conditions: Neck Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: One group will receive only pilates training. Other group participants will receive kinesiobant application in addition to pilates training. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: The researcher who will do the pilates training and taping and the other researcher who will do the pre-test and post-test are blinded. whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 42 type: ESTIMATED name: Pilates name: Pilates and Kinesiotape measure: Neck Disability Index measure: Pain PressureThreshold measure: Muscle Strength measure: Range of Motion measure: Prone Bridge Test measure: Sits Up Test: measure: Postural Habits and Awareness Scale measure: Short Form 36 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tarsus University status: RECRUITING city: Mersin country: Turkey name: Ali Mutlu role: CONTACT name: Ali MUTLU role: PRINCIPAL_INVESTIGATOR lat: 36.79526 lon: 34.61792 hasResults: False
nctId: NCT06262984 id: 2023/21-754 briefTitle: Therapeutic Play Before Nasopharyngeal Swabbing in Children overallStatus: COMPLETED date: 2024-02-19 date: 2024-03-13 date: 2024-03-13 date: 2024-02-16 date: 2024-03-15 name: Maltepe University class: OTHER briefSummary: The study will be conducted with the randomized controlled experimental method. Children who apply to the Child Health and Diseases Polyclinic and Child Health and Diseases Service and who will have nasopharyngeal swab applied will be divided into two groups by drawing lots. After the randomization children in the therapeutic play group the nasal swab will be shown on the doll to the child by the researcher before being taken. The child is then allowed to play with the doll accompanied by the researcher. No intervention will be performed on children in the control group. The parents will also be found next to their children in both groups during the procedure. conditions: Behavior, Coping studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 68 type: ACTUAL name: Therapeutic Play measure: Children's emotional manifestation sex: ALL minimumAge: 3 Years maximumAge: 6 Years stdAges: CHILD facility: Maltepe University city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06262971 id: PCI-LM-Registry-2018 briefTitle: Left Main Percutaneous Coronary Intervention Registry in Istanbul Medipol University Hospital overallStatus: COMPLETED date: 2018-06-01 date: 2022-12-31 date: 2023-12-31 date: 2024-02-16 date: 2024-02-16 name: Medipol University class: OTHER briefSummary: This hospital-based registry study at Istanbul Medipol University Hospital focuses on documenting and analyzing the clinical and demographic characteristics, procedural-related aspects, and both short and long-term outcomes of patients undergoing left main coronary artery percutaneous coronary intervention (PCI). The study aims to identify predictors for adverse clinical outcomes in patients treated for left main coronary artery disease. conditions: Coronary Artery Disease conditions: Left Main Coronary Artery Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 3620 type: ACTUAL name: Percutaneous coronary intervention measure: Incidence of Major Adverse Cardiac Events (MACE) within One Year Following Left Main Coronary Artery PCI measure: Ischemia-Driven Target Vessel Revascularization (ID-TVR) Ischemia-Driven Target Vessel Revascularization (ID-TVR) measure: Procedure-Related Complications Within 30 Days of PCI measure: Health-Related Quality of Life (HRQoL) Scores One Year After PCI measure: Rate of stent thrombosis sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istanbul Medipol University city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06262958 id: KUH5703459 briefTitle: Recognition and Early Intervention for Alcohol and Substance Abuse in Adolescence in Adolescent acronym: REAL-SMART overallStatus: RECRUITING date: 2017-08-07 date: 2030-06-01 date: 2030-06-01 date: 2024-02-16 date: 2024-02-16 name: Kuopio University Hospital class: OTHER briefSummary: ASSIST mini-intervention is applied in an electric form in adolescent outpatients to see if it conditions: Alcoholism conditions: Substance Abuse conditions: Alcohol Dependence conditions: Alcohol-Related Disorders conditions: Substance Use Disorders conditions: Adolescent Behavior conditions: Adolescent Problem Behavior studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Clients are randomized into two groups: 1) those receiving TAU and 2) those receiving a mini-intervention for substance and alcohol use an add-on treatment. primaryPurpose: TREATMENT masking: NONE count: 800 type: ESTIMATED name: ASSIST name: Treatment as usual measure: Decreased consumption of alcohol, tobacco or substances measure: BDI scores measure: GAD scores sex: ALL minimumAge: 14 Years maximumAge: 19 Years stdAges: CHILD stdAges: ADULT facility: Kuopio University Hospital status: RECRUITING city: Kuopio zip: 70110 country: Finland name: Sanna Voutilainen, Res. nurse role: CONTACT phone: +358447175351 email: sanna.voutilainen@kuh.fi lat: 62.89238 lon: 27.67703 hasResults: False
nctId: NCT06262945 id: YDU/2024/120-1808 briefTitle: Comperasion the Postoperative Effect of Low Laser Therapy and Platelet Rich Fibrin on Mandibular Third Molar Surgery. overallStatus: COMPLETED date: 2024-01-02 date: 2024-02-06 date: 2024-02-07 date: 2024-02-16 date: 2024-02-16 name: Beste Erismen class: OTHER briefSummary: The aim of this study was investigate the comparison of postoperative effects of low laser treatment and platelet-rich fibrin application on mandibular impacted third molar tooth extraction. The study included a total of 60 patients with impacted mandibular third molar. Patients were evaluated in 4 randomly separated groups. In group 1, PRF was applied to the tooth socket. In group 2, PRF was applied to the tooth socket combined with Low Laser Treatment extraorally to the extraction area for three days within surgery day In group 3, Low Laser Treatment was applied to the extraorally to the extraction area for three days within surgery day. In group 4 (control group), tradional osteomy was made. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation. All of the 4 groups patients were prescribed an 875/125 mg amoxicillin/clavulanic acid tablet twice daily for five days. conditions: Impacted Third Molar Tooth studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 60 type: ACTUAL name: Diagnoses name: traditional osteotomies name: platelet rich fibrin name: Antibiotics, Penicillin name: low laser therapy, bicure laser name: Analgesic measure: Visual analogue scale (VAS) measure: Visual analogue scale (VAS) measure: Visual analogue scale (VAS) measure: Visual analogue scale (VAS) measure: Trismus measure: Trismus measure: Trismus measure: Trismus measure: Swelling measure: Swelling measure: Swelling measure: Swelling measure: the number of analgesic tablets measure: the number of analgesic tablets measure: the number of analgesic tablets measure: the number of analgesic tablets sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Near East University city: Nicosia state: Lefkosa zip: 99138 country: Cyprus lat: 35.17531 lon: 33.3642 hasResults: False
nctId: NCT06262932 id: RADS regimen briefTitle: Effectiveness of Repeated Amiodarone Dosing Regimen Versus Standard Dosing Regimen in Atrial Fibrillation Patient With Rapid Ventricular Response overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-31 date: 2024-12-31 date: 2024-02-16 date: 2024-04-08 name: Police General Hospital, Thailand class: OTHER briefSummary: The goal of this clinical trial is to compare in atrial fibrillation patient with rapid ventricular response. The main question it aims to answer are Effectiveness of Repeated Amiodarone dosing regimen versus standard dosing regimen in Atrial fibrillation patient with rapid ventricular response Participants will receive Amiodarone iv treatment with different regimen
* Standard dosing regimen conditions: Atrial Fibrillation studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 32 type: ESTIMATED name: Amiodarone measure: Heart rate measure: Normal sinus rhythm at 24 hours measure: Heart rate measure: Major adverse cardiovascular events measure: Phlebitis measure: Changed in heart rate sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06262919 id: CDRB436I1401 briefTitle: Special Drug Use-results Surveillance of Tafinlar/Mekinist overallStatus: RECRUITING date: 2024-02-09 date: 2031-12-31 date: 2031-12-31 date: 2024-02-16 date: 2024-03-22 name: Novartis Pharmaceuticals class: INDUSTRY briefSummary: This is a prospective, multicenter, single-arm, non-interventional and observational J-PMS conducted by the central registration system and operated in Electronic data capture. conditions: BRAF V600E Mutation-positive Unresectable Advanced or Recurrent Solid Tumor studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 90 type: ESTIMATED name: Tafinlar/Mekinist measure: [Pediatric patients] Number of patients and incidence of adverse events/adverse reactions with respect to skeletal and sexual maturation measure: [Adult patients] overall response rate (ORR) measure: [Pediatric patients] Incidence proportion of ORR measure: [Pediatric and adult patients] Incidence proportion of PFS measure: [Pediatric patients] Number of patients with changes in height and body weight and sexual maturation sex: ALL minimumAge: 6 Years maximumAge: 99 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Novartis Investigative Site status: RECRUITING city: Kobe state: Hyogo zip: 650-0011 country: Japan lat: 34.6913 lon: 135.183 facility: Novartis Investigative Site status: RECRUITING city: Akita zip: 010-8543 country: Japan lat: 39.71667 lon: 140.10826 facility: Novartis Investigative Site status: RECRUITING city: Osaka zip: 534-0021 country: Japan lat: 34.69374 lon: 135.50218 facility: Novartis Investigative Site status: RECRUITING city: Osaka zip: 550-0015 country: Japan lat: 34.69374 lon: 135.50218 hasResults: False
nctId: NCT06262893 id: Shoulder nerve blocks briefTitle: Effect of Dexamethasone Adjuvant in Combined Supraclavicular Block and Suprascapular Block Versus Interscalene Block in Patients Undergoing Shoulder Arthroscopy overallStatus: NOT_YET_RECRUITING date: 2024-02-25 date: 2025-12 date: 2026-01 date: 2024-02-16 date: 2024-02-16 name: Assiut University class: OTHER briefSummary: In this study the investigators aim to compare the effect of the suprascapular- supraclavicular nerve block in association with dexamethasone to that of the interscalene brachial plexus block on analgesic effect during arthroscopic shoulder surgery, as postoperative pain scores ,postoperative consumption of analgesic rescue medications and diaphragmatic excursion assessment. conditions: Shoulder Arthroscopy Blocks conditions: Dexamethasone studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: Shoulder arthroscopy blocks measure: Postoperative analgesia by visual analog scale (VAS). measure: Diaphragmatic excursion sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Assiut University city: Assiut country: Egypt name: Assiut University role: CONTACT lat: 27.18096 lon: 31.18368 hasResults: False
nctId: NCT06262880 id: BIO-2305 briefTitle: Dietary Supplementation on Gastrointestinal Barrier Function overallStatus: RECRUITING date: 2024-02-06 date: 2024-12-20 date: 2025-02-06 date: 2024-02-16 date: 2024-03-08 name: Brightseed class: INDUSTRY briefSummary: The purpose of the current study is to examine the effects of a dietary supplement containing plant derived phenolics at two different dose levels on parameters of gastrointestinal (GI) health in otherwise generally healthy adults with risk factors (high BMI and waist circumference) for increased GI permeability. The primary hypothesis is that supplementation with plant derived phenolics will improve gut health compared to placebo. conditions: Intestinal Permeability studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 126 type: ESTIMATED name: plant derived phenolics name: Microcrystaline cellulose (MCC) measure: 0-2 h urine 13C Mannitol excretion measure: 2 to 8 h urine 13C Mannitol measure: 0 to 2 h urine LMR measure: 2 to 8 h urine LMR measure: Blood Biomarkers measure: Blood Biomarkers measure: Blood Biomarkers measure: Fecal Biomarkers measure: Fecal Biomarkers measure: Inflammatory Biomarkers (Blood) measure: Inflammatory Biomarkers (Blood) measure: Inflammatory Biomarkers (Blood) measure: Inflammatory Biomarkers (Blood) measure: 7-day recall of gastrointestinal symptoms measure: 7-day recall of gastrointestinal symptoms measure: Stool frequency measure: Stool consistency measure: Body Weight sex: ALL minimumAge: 30 Years maximumAge: 69 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Biofortis status: RECRUITING city: Addison state: Illinois zip: 60101 country: United States name: Chad Cook role: CONTACT lat: 41.9317 lon: -87.98896 hasResults: False
nctId: NCT06262867 id: ReadySetFood briefTitle: Early Allergen System Experience acronym: EASE overallStatus: NOT_YET_RECRUITING date: 2024-03-07 date: 2026-09-01 date: 2026-09-01 date: 2024-02-16 date: 2024-02-20 name: Prollergy dba Ready Set Food class: OTHER name: ObvioHealth briefSummary: Multiple clinical trials have demonstrated that early allergen introduction, feeding babies common food allergens before six months, decreases children's risk of developing a food allergy. Despite successful food allergy introduction trials showing that food allergies can be prevented, early introduction in the required amount can be challenging for parents. In some studies, less than 20% of parents introduce peanuts before their child is six months old, and few feed them regularly after introduction. Ready. Set. Food! is a direct-to-consumer product that offers a convenient supplement with a daily dose regimen that can be added to breastmilk, formula, or food to make early allergen introduction easy. The formulation includes cow's milk, egg, and peanut, representing the majority of childhood food allergies, and the protein levels are based on doses found to be effective in clinical trials. Over 200,000 infants have used Ready. Set. Food!.
The goal of this study is to assess how Ready. Set. Food! allergen introduction supplements improve the experience of parents introducing allergens, decrease healthcare costs related to food allergies, and decrease food allergy prevalence. conditions: Food Allergy in Infants studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 1110 type: ESTIMATED name: Ready. Set. Food! Stage 1 Mix ins measure: The proportion of caregivers who are adherent with the evidence-based guidance for cow's milk, egg, and peanut during the 6 - month period measure: Frequency of caregiver-reported allergy or food introduction-related adverse events (AEs) after introduction of cow's milk, egg, and peanut measure: Frequency of caregiver-reported serious adverse events (SAEs) after introduction of cow's milk, egg, and peanut measure: Frequency of caregiver-reported special interest adverse events (FPIES and anaphylaxis) after introduction to cow's milk, egg, and peanut by 12 months of age measure: The proportion of caregivers who are satisfied with introduction of egg, cow's milk, and peanut measure: The total allergy-related healthcare costs measure: The proportion of participants with food allergy to cow's milk, egg, or peanut measure: The proportion of participants with a suspected food allergy sex: ALL minimumAge: 2 Months maximumAge: 5 Months stdAges: CHILD hasResults: False
nctId: NCT06262854 id: AOU Careggi Firenze briefTitle: Efficacy and Safety of Stimulan® for the Treatment of Diabetic Foot Osteomyelitis. The BIG D-FOOT Study acronym: BIG D-FOOT overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-05-31 date: 2024-02-16 date: 2024-02-16 name: Azienda Ospedaliero-Universitaria Careggi class: OTHER briefSummary: This study is designed as a double-blind, placebo-controlled, parallel series randomized trial aimed at verifying the effiicacy and safety of a local calcium-sulphate bio-absorbable antibiotic delivery (tobramicina+vancomicina) versus placebo (calcium-sulphate matrix without antibiotics) in patients with diabetic foot osteomyelitis treated with surgical procedures. conditions: Diabete Mellitus conditions: Foot Ulcer conditions: Osteomyelitis - Foot conditions: Surgical Procedure, Unspecified studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Granules of calcium sulphate with and without antibiotics are identical and undistinguishable. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Calcium-sulphate granules with tobramicina+vancomicina measure: The composite primary endpoint of this study will be the incidence osteomyelitis recurrence or new osteomyelitis in adjacent sites or tissue infection at the site of osteomyelitis. measure: Proportion of healed patients measure: Proportion of osteomyelitis recurrence measure: Proportion of post-surgical tissue infection measure: Proportion of wound recurrence measure: Proportion of patients undergoing major amputation measure: Proportion of patients undergoing new surgical intervention measure: Ulcer time-to-healing measure: Osteomyelitis time-to-recurrence measure: Any serious adverse events measure: Any non serious adverse events measure: Proportion of post-surgical dehiscence measure: Direct medical costs sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06262841 id: Murat Kaan Erdem briefTitle: Post-Surgical Morbidity and Bone Healing of Impacted Lower Third Molars: Piezosurgery vs. Conventional Instruments overallStatus: COMPLETED date: 2022-11-01 date: 2023-04-01 date: 2023-04-01 date: 2024-02-16 date: 2024-02-16 name: Ankara University class: OTHER briefSummary: The aim of this study is to compare piezosurgery and conventional surgery in impacted third molar surgery and to determine its effect on postoperative outcomes and quality of life. conditions: Impacted Third Molar Tooth studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 21 type: ACTUAL name: Piezosurgery name: Conventional burs measure: Change in Oral Health-related Quality of Life measure: Change in pain measure: Change in Mouth opening measure: Operation time measure: Change in facial swelling sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Ankara University Faculty of Dentistry city: Ankara state: Çankaya zip: 06510 country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False