hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06303791 id: 1905517 briefTitle: Digital-based Psychosocial Intervention for Parents of Children With Neurodevelopmental Disorders acronym: INPSYD overallStatus: ACTIVE_NOT_RECRUITING date: 2022-09-07 date: 2024-05 date: 2024-12 date: 2024-03-12 date: 2024-03-12 name: University of Valencia class: OTHER briefSummary: The goal of this clinical trial is to implement a structured psychosocial intervention program with digital support (randomized and with a control group) that will be conducted virtually and synchronously to families of children with autism spectrum disorder (ASD) and families of children with Attention Deficit with hyperactivity Disorder (ADHD). The main questions it aims to answer are:
Researchers will compare intervention group and control group to see if there are improvements on parent's domains (parenting stress, coping skills, social support) and children's dysfunctional outcomes (daily life functioning, social behavioral variables, and executive functioning). conditions: Autism Spectrum Disorder conditions: Attention Deficit Hyper Activity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: To test the proposed objectives, a design will be used with a between-groups factor (type of therapy) and a intra-groups with pre-treatment (T0), post-treatment (T1) and follow-up measurements at 6 months (T2). Participants will be randomly assigned (1:1) to the two conditions; a group that will receive the intervention of the structured psychosocial program with digital support (experimental group) and an active control group. The experimental group will undergo an evaluation prior to the intervention, one immediately after it, and a third follow-up evaluation. In the case of the control group, it will be evaluated through the pretest phases, posttest and follow-up. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Families/children who meet the inclusion criteria will be randomly assigned to one of the two conditions (intervention group or control group) using a controlled design. Block randomization will be applied to each of the diagnostic groups (ASD, ADHD) to ensure that participants were of approximately similar size (1:1 ratio) in the treatment and control conditions. After determining the size of each block in the sample (#ASD and #ADHD) the treatment allocation of each individual participant will be done randomly.A blind procedure will be used: participating families will not know the group to which participants will be assigned, and the researchers who will collect and enter the data will also have no knowledge of the condition to which the families will be assigned. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 90 type: ACTUAL name: Digital Psychosocial intervention measure: Parental stress in The Parenting Stress Index - Short Form (PSI-SF) Spanish adaptation measure: Social support: The Social Functional Support Questionnaire Duke-UNC measure: Coping Skills using The Brief COPE measure: Children's social problems using Strengths and Difficulties Questionnaire (SDQ) measure: Daily life executive functioning using the BRIEF measure: Children Sleep problems: using The Sleep Disturbance Scale for Children (SDSC) measure: Behavioral problems using The Weiss Functional Impairment Rating Scale-Parent Form (WFIRS-P) measure: Children Learning Behavior using Learning behavior scale (LBS) sex: ALL minimumAge: 7 Years maximumAge: 11 Years stdAges: CHILD facility: University of Valencia city: Valencia zip: 46010 country: Spain lat: 39.46975 lon: -0.37739 hasResults: False
nctId: NCT06303765 id: 13Nov2023PReDAS Study briefTitle: Evaluating the Practice Resource for Driving After Stroke overallStatus: RECRUITING date: 2024-02-01 date: 2024-07-01 date: 2024-08-31 date: 2024-03-12 date: 2024-04-09 name: Western University, Canada class: OTHER briefSummary: After stroke, individuals must be assessed to determine if they can resume driving. Return to driving is very important to people who have experienced a stroke. Unfortunately, health care providers face challenges in addressing driving after stroke. Common issues include being unsure of the best screening practices, difficulty discussing driving with patients, and challenges making informed recommendations about driving that balance the risk of public safety along with supporting patient goals. Occupational Therapists (OTs) are health care providers that provide screening, assessment, and intervention for driving to individuals who have had a stroke. OTs working in stroke care have highlighted the urgency for evidence-based resources to support practice to address driving with patients. The Practice Resource for Driving After Stroke (PReDAS), is an evidenced-based resource to support the clinical practice of OTs in addressing driving in acute stroke settings. A previous pilot study has demonstrated that the PReDAS is considered useful by both health care providers and patients. Further study is needed to evaluate how the PReDAS can support OTs in addressing driving with patients. The current study proposes to provide the PReDAS as an intervention to OTs working in acute stroke settings to see if the intervention increases OT's self efficacy and clinical reasoning for addressing driving. The study will take repeated measures of self-efficacy and clinical reasoning among participating OTs to determine if the PReDAS intervention supports improved self-efficacy and clinical reasoning. conditions: Stroke, Acute conditions: Driving conditions: Occupational Therapy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: multiple baseline study primaryPurpose: TREATMENT masking: NONE count: 8 type: ESTIMATED name: Practice Resource for Driving After Stroke (PReDAS) measure: clinical reasoning measure: self-efficacy sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Western University status: RECRUITING city: London state: Ontario zip: N6G 1H1 country: Canada name: April K Vander Veen, PhD (c) role: CONTACT phone: 519-661-2111 phoneExt: 89153 email: afrankr2@uwo.ca name: Liliana Alvarez, PhD role: CONTACT phone: 519-661-2111 phoneExt: 88957 email: lalvare2@uwo.ca lat: 42.98339 lon: -81.23304 hasResults: False
nctId: NCT06303752 id: 260-2021-NQ id: 2022-502659-73 type: EUDRACT_NUMBER briefTitle: Tissue Therapy of Transsphincteric Anal Fistula acronym: REP-PAF overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-04-30 date: 2027-04-30 date: 2024-03-12 date: 2024-04-12 name: University of Southern Denmark class: OTHER briefSummary: This clinical study aims to evaluate the outcome of the treatment of complex perianal fistulas (PAF) by the combination of minimal surgical debridement with regenerative cellular therapeutics. conditions: Anal Fistula studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 75 type: ESTIMATED name: ADRC injection name: ADRC001 injection measure: Healing rate (percentage) measure: QoL measure: Fecal Incontinence measure: Risk factors for recurrence of fistula. measure: Radiological healing. measure: Treatment efficacy. measure: Cellular composition measure: Transplantation-related alloantibodies sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Odense University Hospital city: Odense zip: 5000 country: Denmark name: Karam M Sørensen, Ph.D role: CONTACT phone: +4565415190 email: ouh.a.forskningsenheden@rsyd.dk name: Tina D Hansen role: CONTACT phone: +4565415190 email: ouh.a.forskningsenheden@rsyd.dk lat: 55.39594 lon: 10.38831 hasResults: False
nctId: NCT06303739 id: 22-1421 briefTitle: Psilocybin-Assisted Therapy in Treatment-Resistant Depression overallStatus: RECRUITING date: 2024-04-19 date: 2025-09 date: 2026-09 date: 2024-03-12 date: 2024-04-23 name: University of North Carolina, Chapel Hill class: OTHER name: Foundation of Hope, North Carolina briefSummary: The goal of this clinical trial is to test how well psilocybin-assisted therapy works in treating people with depression. The main questions this study aims to answer are:
nctId: NCT06303726 id: IRP-2021/02-19 briefTitle: Comparison of Single-bundle Versus Double-bundle Anterior Cruciate Ligament Reconstruction overallStatus: ACTIVE_NOT_RECRUITING date: 2022-04-25 date: 2024-04-01 date: 2024-06-25 date: 2024-03-12 date: 2024-03-12 name: University Medical Centre Maribor class: OTHER briefSummary: The goal of this retrospective randomized study is to compare two surgical techniques (single vs. double bundle) of ACL (anterior cruciate ligament) reconstructions in participants with rupture of anterior cruciate ligament without major other injuries of the injured knee (exclusion criteria defined).
Participants will be invited to our clinic after 15 years to do clinical and functional exams with x-Ray and magnetic resonance imaging (MRI) of both knees. Subjective exams with different scores (Tegner score, Lysholm score..) were also done. The same exam protocol for participant was used again after two years and fifteen years since surgery. conditions: Anterior Cruciate Ligament Reconstruction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 30 type: ACTUAL name: ACL reconstruction single bundle name: ACL reconstruction double bundle measure: IKDC SUBJECTIVE SCORE measure: TEGNER SCORE measure: LYSHOLM SCORE measure: OBJECTIVE PARAMETER: STREENGHT OF FLEXORS AND EXTENSORS measure: OBJECTIVE PARAMETER: AP TRANSLATION (anterior-posterior) sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: University Clinical Center Maribor city: Maribor zip: 2000 country: Slovenia lat: 46.55472 lon: 15.64667 hasResults: False
nctId: NCT06303713 id: 23-693 briefTitle: LuCarbo - a Study of 177Lu-PSMA-617 Plus Carboplatin in Metastatic Castrate-resistant Prostate Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-07-19 date: 2026-07-19 date: 2024-03-12 date: 2024-03-12 name: Dana-Farber Cancer Institute class: OTHER name: Novartis briefSummary: The purpose of this study is to see whether the combination of a chemotherapy drug, carboplatin, along with the radioligand treatment, 177Lu-PSMA-617, is safe in treating prostate cancer and whether the combination is effective in shrinking or preventing growth of prostate cancer.
* 177Lu-PSMA-617 (A type of radioligand therapy) conditions: Prostate Cancer conditions: Metastatic Prostate Cancer conditions: Metastatic Castration-resistant Prostate Cancer studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 37 type: ESTIMATED name: Carboplatin name: 177Lu-PSMA-617 measure: Maximum tolerated dose (MTD) or the Recommended Phase 2 dose (RP2D) of carboplatin administered in combination with 177Lu-PSMA-617 measure: PSA response rate (PSA reduction by ≥50% from baseline). measure: Overall Response Rate (ORR) measure: Radiographic Progression-Free Survival (rPFS) measure: Overall Survival (OS) sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beth Israel Deaconess Medical Center city: Boston state: Massachusetts zip: 02215 country: United States name: Daniel Fein, MD role: CONTACT phone: 617-667-2100 email: dfein@bidmc.harvard.edu name: Daniel Fein, MD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Brigham and Women's Hospital city: Boston state: Massachusetts zip: 02215 country: United States name: Praful Ravi, MB BCHir, MRCP role: CONTACT phone: 617-632-3466 email: Praful_Ravi@DFCI.HARVARD.EDU name: Praful Ravi, MB BCHir, MRCP role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Dana-Farber Cancer Institute city: Boston state: Massachusetts zip: 02215 country: United States name: Praful Ravi, MB BChir, MRCP role: CONTACT phone: 617-632-3466 email: praful_ravi@dfci.harvard.edu name: Praful Ravi, MB BCHir, MRCP role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06303700 id: Quality of life briefTitle: Dyspnea, Risk of Falling and Quality of Life in Adolescents, Youth and Geriatric Groups overallStatus: COMPLETED date: 2022-05-10 date: 2024-01-31 date: 2024-01-31 date: 2024-03-12 date: 2024-03-12 name: Amira Hussin Hussin Mohammed class: OTHER briefSummary: To assess the correlation between aspects of the dyspnea scale (indicating poor functionality), the fall efficacy scale (indicating a higher fear of falling), and all aspects of the SF36 (indicating quality of life) in 3 age groups: adolescents, youth, and geriatrics. conditions: Public Health studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 604 type: ACTUAL measure: the severity of dyspnea measure: the level of fear of falling through daily life activities measure: quality of life and public health sex: ALL minimumAge: 12 Years maximumAge: 80 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Amira Hussin Mohammed city: Gamasa zip: 35712 country: Egypt lat: 31.44112 lon: 31.53675 hasResults: False
nctId: NCT06303687 id: STUDY00003496 briefTitle: VR-PAT and fNIRS to Identify CNS Biomarkers of Pain overallStatus: ENROLLING_BY_INVITATION date: 2024-03 date: 2024-06 date: 2024-06 date: 2024-03-12 date: 2024-03-12 name: Nationwide Children's Hospital class: OTHER briefSummary: This study aims to use functional near-infrared spectroscopy (fNIRS) to identify and quantify pain biomarkers during burn dressing changes and pain relief induced by virtual reality (VR). conditions: Acute Pain conditions: Pediatric ALL conditions: Procedural Pain conditions: Burns studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Participants will be randomly assigned to either the intervention (fNIRS and VR-PAT) or the control (fNIRS and standard of care) at the first research dressing change and will then crossover to the alternative group for the second laser procedure. primaryPurpose: DIAGNOSTIC masking: NONE count: 4 type: ESTIMATED name: VR-PAT measure: Change in brain activity measure: Procedural pain during burn dressing changes measure: Change in procedural anxiety measure: Self-reported VR experience sex: ALL minimumAge: 6 Years maximumAge: 17 Years stdAges: CHILD facility: Nationwide Children's Hospital city: Columbus state: Ohio zip: 43205 country: United States lat: 39.96118 lon: -82.99879 hasResults: False
nctId: NCT06303648 id: TSND201-PK-101 briefTitle: A Single, Ascending Dose Evaluation of the Safety, Pharmacokinetics of Methylone in Healthy Subjects overallStatus: RECRUITING date: 2024-03-20 date: 2024-05-04 date: 2024-05-11 date: 2024-03-12 date: 2024-04-16 name: Transcend Therapeutics class: INDUSTRY briefSummary: This is an open-label, single, ascending dose study evaluating the PK and safety of methylone in healthy subjects. conditions: Post Traumatic Stress Disorder studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: Subjects will be enrolled into one of four cohorts. The study will begin enrolling Cohort 1. primaryPurpose: TREATMENT masking: NONE count: 24 type: ESTIMATED name: Methylone measure: Cmax: Maximum Observed Plasma Concentration for methylone measure: AUC: Area under the plasma concentration-time curve for methylone measure: Incidence and frequency of adverse events measure: Change overtime in Visual Analog Scales sex: ALL minimumAge: 25 Years maximumAge: 55 Years stdAges: ADULT facility: CMAX Clinical Research status: RECRUITING city: Adelaide state: South Australia zip: 5000 country: Australia name: Research Team role: CONTACT lat: -34.92866 lon: 138.59863 hasResults: False
nctId: NCT06303635 id: UFRJvac-1 briefTitle: Safety of UFRJvac, Trivalent COVID-19 Vaccine acronym: UFRJvac-1 overallStatus: NOT_YET_RECRUITING date: 2024-06-24 date: 2025-10-16 date: 2025-11-25 date: 2024-03-12 date: 2024-03-12 name: Azidus Brasil class: INDUSTRY name: Universidade Federal do Rio de Janeiro briefSummary: Phase I study to evaluate the safety and immunogenicity of the vaccine booster with the trivalent UFRJvac COVID-19 vaccine. conditions: Healthy People studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 156 type: ESTIMATED measure: Evaluate the safety and reactogenicity of the UFRJvac COVID-19 vaccine booster measure: Evaluate the safety and reactogenicity of the vaccine booster with the trivalent UFRJvac COVID-19 measure: Evaluate the humoral immunogenicity of the vaccine booster with the trivalent UFRJvac COVID-19 measure: Evaluate the humoral immunogenicity of the vaccine booster the trivalent UFRJvac COVID-19 measure: Evaluate the humoral immunogenicity of the vaccine booster with the trivalent UFRJvac measure: Evaluate the humoral immunogenicity of the vaccine booster trivalent UFRJvac measure: Evaluate the cellular immunogenicity of the vaccine booster with the trivalent UFRJvac COVID-19 sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06303622 id: CRE-2023.610 briefTitle: Comparing MRI-Ultrasound Fusion and Cognitive-guided Biopsy for the Detection of csPCa: the PROFUSION Trial overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-12-31 date: 2027-03-31 date: 2024-03-12 date: 2024-04-10 name: Chinese University of Hong Kong class: OTHER briefSummary: This study is an international multicentre RCT to compare the linically significant prostate cancer (csPCa) detection of cognitive-guided and MRI-USG guided biopsies in men with suspicious MRI lesion. conditions: Prostate Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 1250 type: ESTIMATED name: MRI-USG fusion approach name: Cognitive-guided approach measure: Proportion of men with clinically significant Prostate cancer(csPCa) measure: Proportion of men with a diagnosis of csPCa in MRI lesions with maximal size ≤10mm versus >10mm measure: Proportion of men with a diagnosis of csPCa in prostate size of ≤50ml vs >50m measure: The proportion of men with a diagnosis of csPCa only in targeted biopsy measure: Proportion of men with a diagnosis of csPCa only in systemic biopsy measure: Proportion of men with a diagnosis of clinically insignificant PCa, measure: Procedure time measure: Pain score on a scale of 0-10 taken after biopsy measure: Proportion of men with post-biopsy adverse events within 30 days after biopsy sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Prince of Wales Hospital city: Hong Kong country: Hong Kong lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06303609 id: 61102222.5.0000.5544 briefTitle: Effects of Non-ablative Radiofrequency on Female Genito-pelvic Pain Disorder acronym: Pelvic Pain overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2026-06-20 date: 2026-07-20 date: 2024-03-12 date: 2024-03-18 name: Centro de Atenção ao Assoalho Pélvico class: OTHER briefSummary: The goal of this randomized clinical trial is to verify the response of genito-pelvic pain disorders in women associated with inability to penetrate to the treatment with non-ablative radiofrequency. The main question it aims to answer is: Does non-ablative radiofrequency have a positive effect on the symptoms of genito-pelvic pain disorders associated with inability to penetrate? Before starting the intervention and at one week, one-, three- and six months after the end of the study, participants will be evaluated with 03 questionnaires (Female Sexual Function Index, Sexual Quality of Life and Perceived Stress Scale-10) and will score the visual analogue scale the level of pain with the penetration (from 0 to 10); participants will then undergo digital evaluation of the pelvic floor muscles, using vaginal dilators and electromyographic evaluation. After being randomized, participants will be divided into the Experimental Group and the Sham Group, being submitted to • the use of non-ablative radiofrequency in the anal and urogenital triangles, • the positioning of the vaginal dilator at the end of each session • and participants will be instructed to use the vaginal dilator at home daily. The researchers will compare the groups in relation to the ability to penetrate with reduced vaginal pain, sexual function, quality of sexual life and the correlation between pelvic muscle activity and perceived stress. conditions: Pelvic Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 56 type: ESTIMATED name: nonablative radiofrequency name: Vaginal dilator name: Sham nonablative radiofrequency measure: Penetration capacity with reduced vaginal pain measure: Sexual function measure: Quality of sexual life measure: Stress perception sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT hasResults: False
nctId: NCT06303596 id: Hippotherapy in Schizophrenia briefTitle: Hippotherapy in Patients With Schizophrenia overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2024-08-01 date: 2024-10-01 date: 2024-03-12 date: 2024-03-12 name: Erzurum Technical University class: OTHER briefSummary: This study will determine the efficacy of hippotherapy (horseback-riding) program, as an adjuvant to standard psychiatric treatment, on the outcomes of patients with schizophrenia. A randomized controlled trial is conducted in a Community Mental Health Center. All participants are randomized into two groups (experimental and control groups) using blocked randomization. All participants received the standard psychiatric treatment, while the experimental group is additionally provided with a 16-session hippotherapy program for 8 weeks. All participants will be evaluated using the Positive and Negative Syndrome Scale, State-Trait Anxiety Inventory, Quality of Life Scale, UCLA Loneliness Scale at both baseline and after the intervention. conditions: Equine-Assisted Therapy conditions: Schizophrenia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: The evaluator who collects the data is blinded to the allocation of groups. whoMasked: OUTCOMES_ASSESSOR count: 88 type: ESTIMATED name: Hippotherapy name: Standard psychiatric treatment measure: The Positive and Negative Syndrome Scale (PANSS) measure: State-Trait Anxiety Inventory (STAI) measure: The Quality of Life Scale (QLS) measure: UCLA Loneliness Scale sex: ALL minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Erzurum Technical University, Erzurum Community Mental Health Center city: Erzurum zip: 25010 country: Turkey name: Musa Eymir, Ph.D., PT, Assist. Prof. role: CONTACT phone: +904424445388-2733 email: musa.eymir@erzurum.edu.tr lat: 39.90861 lon: 41.27694 hasResults: False