Participants will follow two diet plans, a 4-week intervention with 60-65 E% carbohydrates and a 4 week intervention with 40-45 E% carbohydrates. conditions: Porphyria, Acute Intermittent studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: The study is a crossover study involving 50 individuals with AIP. The study design was chosen to determine whether the treatment has an effect compared to baseline analyses and whether the sequence of treatment has an effect, as well as whether one of the interventions is more effective than the other. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Blinding is attempted by labeling the provided diet plans as A and B. The physician recording outcome variables and the researcher performing statistical analysis are blinded to the given diet. whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Carbohydrates measure: Change in Urine Porphobilinogen/creatinine measure: Urine Porphobilinogen/creatinine concentration, percentage change of repeated measurements measure: Number of Hospitalizations,sick leaves, and doctor visits due to AIP measure: Health status measure: Plasma Glucose level measure: Interstitial fluid glucose level measure: Number of hypoglycemic events measure: Amino acid profile measure: Plasma insulin, glucose, c-peptide measure: HOMA score measure: HbA1c measure: Cytokines in plasma measure: Intestinal microbiota composition measure: Physical activity measure: Blood pressure measure: Body composition, metabolic age measure: Mitochondrial oxygen consumption rate measure: ALAS1mRNA measure: Urine-ALA/creatinine & urine-porphyrins measure: Mitochondrial function-related genes sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Nordland Hospital Trust status: RECRUITING city: Bodø state: Nordland zip: 8092 country: Norway name: Elin Storjord, MD PhD role: CONTACT phone: +4797072484 email: elin.storjord@nordlandssykehuset.no name: Hilde Thunhaug, IC nurse role: CONTACT phone: +47 95057864 email: hilde.thunhaug@nordlandssykehuset.no name: Elin Storjord, MD PhD role: PRINCIPAL_INVESTIGATOR name: Amy Dickey, MD role: SUB_INVESTIGATOR name: Bjørn Steen Skålhegg, PhD, Prof. role: SUB_INVESTIGATOR name: Bård O. Karlsen, PhD role: SUB_INVESTIGATOR name: Elin Røst, Master role: SUB_INVESTIGATOR name: Erik Knutsen, PhD role: SUB_INVESTIGATOR name: Hilde Thunhaug, Bachelor role: SUB_INVESTIGATOR name: Jonas Aakre Wik, PhD role: SUB_INVESTIGATOR name: Andersen Karl, MD, Prof. role: SUB_INVESTIGATOR name: Pettersen Kristin, Bachelor role: SUB_INVESTIGATOR name: Marlene B. Karlsen, Master role: SUB_INVESTIGATOR name: Nina Lorentsen, Master role: SUB_INVESTIGATOR name: Ole-Lars Brekke, MD,PhD,Prof role: SUB_INVESTIGATOR name: Randolf Hardersen, MD, PhD role: SUB_INVESTIGATOR name: Rita Laastad, Bachelor role: SUB_INVESTIGATOR name: Steinar Daae Johansen, PhD, Dean role: SUB_INVESTIGATOR name: Tor Erik Jørgensen, PhD role: SUB_INVESTIGATOR name: Vegar Rangul, PhD role: SUB_INVESTIGATOR name: Åse Emblem, PhD role: SUB_INVESTIGATOR name: Fredrik Ellefsrud, MD role: SUB_INVESTIGATOR name: Tor Claudi, MD role: SUB_INVESTIGATOR lat: 67.28 lon: 14.40501 hasResults: False