hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06353750 id: 331039 briefTitle: Intracellular Magnesium and Heart Failure overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-02-28 date: 2026-04-25 date: 2024-04-09 date: 2024-04-09 name: University of Oxford class: OTHER name: British Heart Foundation name: Oxford University Hospitals NHS Trust briefSummary: Low magnesium levels are surprisingly common in those with a heart condition known as HFpEF, where the heart pumps well but is too rigid to fill properly with blood. While routine blood tests can check magnesium levels, they don't tell us how much magnesium is actually inside the heart and muscle cells, where it's vital for energy and overall function. Our research aims to get a clearer picture by looking directly at the magnesium inside these cells and understanding its role in the body's energy production and usage. We're also interested in how magnesium levels affect symptoms and the body's handling of sugar. We're using advanced medical imaging techniques, like heart magnetic resonance imaging (MRI) and other heart and muscle function tests, at rest and when the heart is working hard to help answer these questions. We'll compare the magnesium levels inside the cells before and after giving a supplement of magnesium to see if this can make a difference in how the heart and muscles work. conditions: Heart Failure With Preserved Ejection Fraction conditions: Hypomagnesemia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 85 type: ESTIMATED name: Magnesium supplement measure: Myocardial/ skeletal muscle metabolism and energetics at rest and stress. measure: Serum versus intracellular magnesium concentration measure: Cardiac function measure: Skeletal muscle performance measure: Symptoms measure: Insulin sensitivity sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Oxford Centre for Magnetic Resonance (OCMR) city: Oxford zip: OX3 9DU country: United Kingdom name: Jennifer L Holland, BMBS role: CONTACT email: jennifer.holland@wolfson.ox.ac.uk name: Oliver Rider, BM BCh role: CONTACT email: oliver.rider@cardiov.ox.ac.uk lat: 51.75222 lon: -1.25596 hasResults: False
nctId: NCT06353737 id: CTO 4489 briefTitle: Looking for Asymptomatic Mpox in a Population at High Risk acronym: LAMP overallStatus: RECRUITING date: 2024-04-01 date: 2026-03-31 date: 2026-03-31 date: 2024-04-09 date: 2024-04-18 name: Unity Health Toronto class: OTHER briefSummary: Mpox is caused by a virus that can be spread through touching the affected skin of someone who has the infection, touching sheets or clothes that has been used by someone with the infection, or breathing in particles of virus from someone who has the infection. Mpox infection can cause skin and flu-like symptoms, but can also cause very few symptoms, or no symptoms at all. While the number of participants with mpox symptoms can be tracked, little is known about how many people have mpox, but experience few or no symptoms at all. To do this, a Canadian sample of gay, bisexual and other men who have sex with men (GBMSM) who are participating in a randomized controlled trial will be screened for mpox symptoms. Screening will include questions about whether they may be experiencing any mpox symptoms, history of past diagnosis of mpox, sexual history, and vaccination history and awareness. Swabs will be taken to test for the presence of mpox virus, and a blood sample will be taken to test for antibodies. Approximately 450 individuals will be recruited. The results will be descriptive in nature. conditions: Mpox (Monkeypox) studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 450 type: ESTIMATED measure: Asymptomatic prevalence measure: Symptomatic prevalence measure: Mpox seropositivity measure: Characteristics measure: Characteristics of seropositivity sex: MALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Unity Health Toronto status: RECRUITING city: Toronto state: Ontario zip: M5B 1T8 country: Canada name: Reva Persaud role: CONTACT phone: 416-360-4000 phoneExt: 77105 email: reva.persaud@unityhealth.to name: Darrell HS Tan role: PRINCIPAL_INVESTIGATOR lat: 43.70011 lon: -79.4163 hasResults: False
nctId: NCT06353724 id: RP2218 briefTitle: Comparison Between the Effect of Using Conventional and Digital Oral Positional Radiation Stent acronym: stent overallStatus: COMPLETED date: 2019-10-14 date: 2020-10-01 date: 2021-01-01 date: 2024-04-09 date: 2024-04-09 name: Tanta University class: OTHER briefSummary: The goal of this clinical trial is to compare between the Effect of Using Conventional and Digital Oral Positional Radiation Stent on Healthy tissues, salivary PH. The main question it aims to answer are: Does the difference in manufacturing method affect on Healthy tissues, salivary PH.
* Group B: OPRS was constructed digitally using CAD /CAM technology. to evaluate Dosimetric analysis to quantify the radiation dose in OARs, PH of saliva measurement and Mucositis assessment. conditions: Radiotherapy Side Effect studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 16 type: ACTUAL name: conventional oral positioning stent were used during radiation planning and the PTV will be defined and contoured in computed tomography pre irradiation planning name: Digital positioning stent measure: Dosimetric analysis measure: PH of saliva measurement: measure: Mucositis assessment: sex: ALL minimumAge: 20 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Dentistry city: Tanta state: Gharbia zip: 31527 country: Egypt lat: 30.78847 lon: 31.00192 hasResults: False
nctId: NCT06353711 id: IRB-23-0746 id: R34MH129782 type: NIH link: https://reporter.nih.gov/quickSearch/R34MH129782 briefTitle: CA-LINC Black Youth Suicide Detection and Intervention Study acronym: CA-LINC overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-03 date: 2025-05 date: 2024-04-09 date: 2024-04-10 name: University of North Carolina, Charlotte class: OTHER name: National Institute of Mental Health (NIMH) briefSummary: The Culturally Adapted Linking Individuals Needing Care (CA-LINC) study will recruit a sample of Black youth to participate in a two-arm parallel-comparison single-blinded pilot randomized control trial (RCT). For the pilot RCT, 68 Black youth participants ages 14-19 who meet the inclusion criteria will be randomly assigned to one of two conditions: CA-LINC (n=34) or TAU (n=34).
CA-LINC is a 90-day culturally adapted LINC intervention developed with and for Black youth. The CA-LINC intervention integrates engagement and follow-up strategies to assess/monitor suicide risk, facilitate service use referrals/linkages, develop/reﬁne safety plans, and create villages of care. The CA-LINC intervention incorporates African-centered principles and empowerment and motivational strategies aimed to support, enhance strengths, promote hope, improve family relationships, and reinforce caring messages. This consumer-, community-, and theory-driven care coordination intervention is designed to reduce suicide ideation and behavior (SIB) by improving service engagement and delivery standards.
CA-LINC is implemented by Peer Support Specialists and Community Health Workers assigned to mental health "hubs" in Black Faith-Based Organizations (FBOs) that facilitate standardization and access to care for Black youth/families regardless of religious affiliation. Black FBOs effectively mobilize Black communities to promote positive health behaviors. The RCT will explore the "fit" of the culturally adapted intervention (CA-LINC) in Black communities in Charlotte, North Carolina, and inform a scalable RCT for a future study. conditions: Suicide conditions: Suicide Prevention studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 68 type: ESTIMATED name: CA-LINC Intervention name: Treatment as Usual measure: Change in Suicide Ideation measure: Change in Suicide Behaviors measure: Treatment Acceptability measure: Change in Therapeutic Alliance measure: Change in Cultural Humility measure: Change in Family Relationships measure: Change in Engagement Behaviors sex: ALL minimumAge: 14 Years maximumAge: 19 Years stdAges: CHILD stdAges: ADULT facility: The University of North Carolina at Charlotte city: Charlotte state: North Carolina zip: 28223 country: United States name: Sonyia Richardson, PhD role: CONTACT phone: 704-687-7935 email: smcopela@charlotte.edu name: Sonyia C Richardson, PhD role: PRINCIPAL_INVESTIGATOR lat: 35.22709 lon: -80.84313 hasResults: False
nctId: NCT06353698 id: Nnftri briefTitle: Fasting Mimicking Diet With Chemotherapy in Patients With Leukemia overallStatus: RECRUITING date: 2023-07-02 date: 2024-04-01 date: 2024-05-01 date: 2024-04-09 date: 2024-04-09 name: National Nutrition and Food Technology Institute class: OTHER briefSummary: The goal of this clinical trial is to investigate The effect of fasting mimicking diet with chemotherapy on the number of blasts and platelets and quality of life in patients with acute lymphoid leukemia and acute myeloid leukemia. conditions: Fasting Mimicking Diet conditions: Leukemia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: fasting mimicking diet measure: Blast cell count measure: Quality of life sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Azita Hekmatdoost status: RECRUITING city: Tehran state: Middle East zip: 19835 country: Iran, Islamic Republic of name: Azita Hekmatdoost, MD, PhD role: CONTACT phone: +989123065084 email: a_hekmat2000@yahoo.com lat: 35.69439 lon: 51.42151 facility: Ehsan Hejazi status: RECRUITING city: Tehran zip: 19839-63113 country: Iran, Islamic Republic of name: Ehsan Hejazi, PhD role: CONTACT phone: 00989121530775 email: ehsanhejazi@sbmu.ac.ir lat: 35.69439 lon: 51.42151 hasResults: False
nctId: NCT06353685 id: neo-CHART-HNC briefTitle: De-Escalation Postoperative Radiotherapy for Oral Squamous Cell Carcinoma With pCR/MPR. overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-12-31 date: 2028-12-31 date: 2024-04-09 date: 2024-04-19 name: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University class: OTHER briefSummary: The prognosis of locally advanced oral squamous cell carcinoma(OSCC ) is poor, and there are still many problems to be solved in the current treatment paradigm. Neoadjuvant chemotherapy combined with immunotherapy can significantly improve the pCR and MPR rates in patients with locally advanced OSCC. For patients who achieve pCR and MPR after neoadjuvant therapy and surgery, it is still hotly debated regarding whether to implement postoperative de-escalation radiotherapy. Neoadjuvant therapy is an ideal predictor of radiosensitivity. In theory, neoadjuvant therapy can eliminate microscopic lesions, thereby reducing the dose and volume of irradiation.
Continuous hyperfractionated accelerated radiotherapy (CHART, based on hyperfractionated radiotherapy, increasing daily or weekly treatments and shortening the total treatment duration, but reducing the total dose), is to give a higher dose of radiation to tumor tissue in a shorter period of time, so as to overcome the accelerated reproliferation and inhibit the repair of sublethal damage of tumor cells. It is beneficial to improve the local control rate of tumor, control the acute injury of normal tissue and the yield acceptable late treatment-related complications. The specific protocol was as follows: high-risk CTV area (CTV1), 45Gy in total, fraction dose of 1.5Gy, twice a day, bioequivalent dose (BED) of 51.75Gy; Low-risk CTV area(CTV2), 39Gy in total , fraction dose of 1.3Gy, twice a day, BED of 44.07Gy; A total of 30 radiotherapy fraction were performed 10 times a week for 3 weeks. conditions: De-escalated Radiotherapy; Head and Neck Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 103 type: ESTIMATED name: Continuous, hyperfractionated, accelerated radiotherapy(CHART) measure: 2-year PFS measure: 2-year OS sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06353672 id: RLR-01 briefTitle: A Study to Evaluate Safety and Feasibility of Robotic Liver Resection overallStatus: RECRUITING date: 2020-12-01 date: 2025-12-31 date: 2026-12-31 date: 2024-04-09 date: 2024-04-09 name: Zhejiang University class: OTHER briefSummary: The robotic surgery system, the most advanced technology in minimally invasive surgery, overcame some shortcomings of laparoscopic surgery and improved the flexibility and precision of liver resection. Several studies have demonstrated that the robotic system was safe and feasible in liver surgery and might be advantageous in complex hepatic vein and hilar dissection, operative bleeding control, and biliary reconstruction. Previous comparative studies found limited evidence for significantly improved outcomes in robotic liver resection (RLR) over laparoscopic liver resection (LLR) or open liver resection (OLR), considering the various degrees of difficulty in liver surgeries.
This study aimed to evaluate safety and feasibility of robotic liver resection, by comparing it with LLR or OLR, and gain veritable and relevant data on the benefits of RLR. conditions: Liver Diseases conditions: Surgery studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 1000 type: ESTIMATED name: Robotic liver resection measure: Postoperative complications measure: Postoperative hospital stay measure: Postoperative unplanned reoperation measure: Unplanned readmission sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: First Affiliated Hospital, Medical College of Zhejiang University status: RECRUITING city: Hangzhou state: Zhejiang zip: 310003 country: China name: Tingbo Liang, MD,PHD role: CONTACT phone: 086-571-87236688 email: liangtingbo@zju.edu.cn lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06353659 id: M2024077 briefTitle: The Diagnostic Value of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-06-30 date: 2026-06-30 date: 2024-04-09 date: 2024-04-09 name: Peking University Third Hospital class: OTHER briefSummary: The goal of this observational study is to quantitatively assess the renal microcirculation changes by contrast-enhanced ultrasound (CEUS) and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore the diagnostic value of CEUS in critically ill acute kidney injury. conditions: Intensive Care Unit conditions: Acute Kidney Injury conditions: Ultrasound studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: Contrast-enhanced Ultrasound measure: Acute kidney injury (according to KDIGO 2012 criteria) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06353646 id: XKY-C-004 briefTitle: XH001 Combination With Ipilimumab and Chemotherapy for Patients With Resected Pancreatic Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-06 date: 2026-12 date: 2024-04-09 date: 2024-04-09 name: Wu Wenming class: OTHER name: NeoCura briefSummary: This is a single-center, open label, single-arm, investigator-initiated study to evaluate the efficacy and safety of XH001 (neoantigen cancer vaccine) sequential combination with ipilimumab and chemotherapy in pancreatic cancer patients following surgical resection. conditions: Pancreatic Cancer studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: XH001 name: Ipilimumab Injection name: Chemotherapy measure: DFS measure: 1-year DFS rate measure: MFS measure: OS measure: Elispot measure: Adverse Event measure: ctDNA measure: CA19-9 sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking Union Medical College Hospital city: Beijing state: Beijing zip: 100730 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06353633 id: AHekmatdoost briefTitle: The Effect of Exclusion Diet for Crohn's Disease Plus Enteral Nutrition on Children and Adolescents With Crohn's Disease overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-10-20 date: 2024-12-25 date: 2024-04-09 date: 2024-04-09 name: National Nutrition and Food Technology Institute class: OTHER briefSummary: In this study, children and adolescents with active Crohn's disease are placed in two intervention groups, the first group receives only an exclusion diet and the second group receives an exclusion diet plus formula. conditions: Inflammatory Bowel Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 44 type: ESTIMATED name: formula name: exclusion diet measure: PCDAI measure: CRP measure: ESR measure: FC measure: Alb measure: Arm Circumferance measure: BMI measure: Height measure: weight sex: ALL minimumAge: 4 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06353620 id: 1018 briefTitle: Structural-functional Connectome in Drug-resistant Epilepsies and Neurodevelopmental Syndromes With Epilepsy overallStatus: RECRUITING date: 2024-02-13 date: 2024-03-18 date: 2027-02-28 date: 2024-04-09 date: 2024-04-09 name: IRCCS Eugenio Medea class: OTHER briefSummary: Recent studies have shown that the aperiodic part of the signal (neuronal avalanches) of electroencephalography (EEG) contains important information about the dynamics of neuronal networks. Indeed, this has helped to identify functionally altered areas in patients with temporal epilepsy by simply using the resting EEG signal. Furthermore, it has been seen that the propagation of neuronal avalanches (VNs) correlates with the morphological organization of the cerebral cortex. Therefore, NAs represent a measure with direct utility for studying functional reorganization pre and post drug/surgical treatment. In addition, the aperiodic portion of the signal may represent a noninvasive measure of the excitation/inhibition relationship, which is known of being altered both in epilepsy and in some rare neurodevelopmental syndromes (example: Angelman and Dup15q) conditions: Epilepsy conditions: Angelman Syndrome conditions: Dup15q Syndrome studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 120 type: ESTIMATED name: High Density EEG recording name: Rey Complex Figure Test measure: Differences in the network coherence values in theta and alpha band after treatment measure: Stability of the alpha frequency band in the EEG activity measure: Correlation of neural excitation and memory performance sex: ALL minimumAge: 6 Years maximumAge: 75 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS E.Medea status: RECRUITING city: Conegliano state: Treviso zip: 31015 country: Italy name: Duma Gian Marco, PhD role: CONTACT phone: +39 0438414248 email: gianmarco.duma@lanostrafamiglia.it lat: 45.88805 lon: 12.30201 hasResults: False
nctId: NCT06353607 id: 2023-02267; kt23Berdajs briefTitle: Genetic Architecture of Acute Aortic Syndromes and Aortic Aneurysm. overallStatus: RECRUITING date: 2024-04-08 date: 2028-12-31 date: 2028-12-31 date: 2024-04-09 date: 2024-04-22 name: University Hospital, Basel, Switzerland class: OTHER briefSummary: The aim of this study is to explore the genetic information associated with the development of TAA and aAD in individuals without history or syndromic features (Marfan syndrome, Ehlers-Danlos syndrome, Turner syndrome etc.) for aortic disease. For this purpose, whole genome sequencing will be performed in patients with documented aortic aneurysm or/and aortic dissection. conditions: Acute Aortic Dissection conditions: Thoracic Aortic Aneurysm studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 730 type: ESTIMATED measure: Assessment of the association between the prevalence of TAA and/or aAD in variants with genes associated with thoracic aortic disease. measure: Investigate the genetic landscape of aortic specimens retrieved from surgical intervention tissues, and relate the genetic profile to cell molecular pathology. measure: To assess the association between the aortic segment dimension (in CT scan and TEE images), tissue pathology and gene variants to determine the images predictive factors for TAA and/or aAD. measure: To establish a risk prediction model for aAD and TAA based on genetic, clinical, and imaging endpoints. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Basel status: RECRUITING city: Basel zip: 4031 country: Switzerland name: Denis Berdajs, Prof. Dr. role: CONTACT phone: 0041 61 328 71 80 email: denis.berdajs@usb.ch name: Islam Salikhanov, Dr. role: CONTACT phone: 0041 61 26 53225 email: islam.salikhanov@usb.ch lat: 47.55839 lon: 7.57327 hasResults: False
nctId: NCT06353594 id: COPERNICAN TRIAL briefTitle: Reduced Stent Strategy Versus Conventional Percutaneous Coronary Revascularization in Patients Presenting With STEMI acronym: COPERNICAN overallStatus: RECRUITING date: 2024-03-11 date: 2026-09 date: 2035-09 date: 2024-04-09 date: 2024-04-09 name: Jorge Sanz Sanchez class: OTHER briefSummary: The objective is to compare a reduced stent strategy based on drug-coated balloon (DCB) percutaneous coronary intervention (PCI) with conventional drug-eluting stent (DES) coronary revascularization in patients presenting with ST-segment myocardial infarction (STEMI).
nctId: NCT06353568 id: 5.888.210 briefTitle: Effect of Photobiomodulation as a Preventive Treatment for Diabetic Foot overallStatus: NOT_YET_RECRUITING date: 2024-05-30 date: 2027-10-30 date: 2027-12-30 date: 2024-04-09 date: 2024-04-09 name: University of Nove de Julho class: OTHER briefSummary: This study seeks to evaluate the effect of photobiomodulation (PBM) in the prevention of Diabetic foot (DF), in patients at moderate and high risk for its development, through a controlled, randomized, double-blind clinical trial. Individuals between 18 and 75 years old of both sexes, with type 2 diabetes mellitus (DM), and moderate and high risk for DF will be randomized and allocated into 2 groups of 32 participants each. The PBM Group will use a boot with 1344 LEDs, 504 of which are 660 nm located on the sides of the boot (28.5 milliwatt, 10 J per LED); 504 850 nm also located on the sides of the boot (23 milliwatt, 8 J per LED); 168 of 660 nm located at the base of the boot (28.5 milliwatt, 10 J per LED); 168 of 850 nm also located at the base of the boot (23 milliwatt, 8 J per LED) once a day for 6 minutes, for 60 days and will receive therapeutic education. Participants will be evaluated at baseline, after 30 days (clinical examination) and after 60 days (clinical examination, Peripheral Neuropathy (PN) assessment, Peripheral Artery Disease (PAD) assessment, blood and urine tests, and quality of life). conditions: Diabetic Foot studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The PBM Group will use a boot with 1344 LEDs once daily for 6 minutes, over 60 days, and will receive therapeutic education.