hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06366256 id: 1R01DC017301-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R01DC017301-01 briefTitle: Simplified Ultrasound Feedback for Speech Remediation acronym: SUFSR overallStatus: RECRUITING date: 2023-10-24 date: 2024-12 date: 2025-08 date: 2024-04-15 date: 2024-04-15 name: University of Cincinnati class: OTHER briefSummary: Recent research in motor control shows that people learn new movements best when they receive feedback external to the body. Traditional ultrasound speech therapy works well for many children, but involves teaching children to focus on their internal tongue movements. The goal of the study is to test whether ultrasound biofeedback delivered without showing children a display of their tongue movements will be effective as a treatment for residual speech sound disorders in children. We focus on children who have trouble producing the sound "r" as in "rabbit". The first aim is to develop a fast reliable system to track movements of different parts of the tongue using ultrasound and to identify which combinations of movements will produce a good "r" and which do not. The second aim is to develop a motivational game in which children receive feedback on the success of their tongue movements by what happens to an animated character on a screen. This developed version of ultrasound feedback therapy will be compared to the traditional version of ultrasound feedback therapy to determine how the two approaches can best be utilized in the clinic. conditions: Speech Sound Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: Traditional ultrasound biofeedback name: Simplified ultrasound biofeedback measure: Change in percent accurate words in probe list at beginning and midpoint of study measure: Change in percent accurate words in probe list at beginning and end of study sex: ALL minimumAge: 7 Years maximumAge: 17 Years stdAges: CHILD facility: University of Cincinnati status: RECRUITING city: Cincinnati state: Ohio zip: 45220 country: United States name: Suzanne E Boyce, PhD role: CONTACT phone: 513-558-8509 email: boycese@ucmail.uc.edu name: Sarah M Dugan, PhD role: CONTACT email: hamilsm@ucmail.uc.edu lat: 39.12713 lon: -84.51435 hasResults: False
nctId: NCT06366243 id: CVL-231-HV-1012 briefTitle: A Trial to Evaluate the Effect of Esomeprazole on the Pharmacokinetics of Emraclidine in Healthy Adult Participants overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2024-06-24 date: 2024-06-24 date: 2024-04-15 date: 2024-04-15 name: Cerevel Therapeutics, LLC class: INDUSTRY briefSummary: The primary purpose of this study is to evaluate the potential of gastric pH-dependent drug-drug interaction effect of esomeprazole, a proton pump inhibitor (PPI), on the pharmacokinetics (PK) of emraclidine in healthy adult participants. conditions: Healthy Participants studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Emraclidine name: Esomeprazole measure: Maximum Observed Plasma Concentration (Cmax) of Emraclidine measure: Time to Maximum (Peak) Plasma Concentration (Tmax) of Emraclidine measure: Area Under the Plasma Concentration-time Curve From Time 0 to the Time of Last Quantifiable Concentration (AUC0-t) of Emraclidine measure: Area Under the Plasma Concentration-time Curve From Time 0 Extrapolated to Infinity (AUC0-inf) of Emraclidine measure: Number of Participants With Treatment-emergent Adverse Events (TEAEs) measure: Number of Participants with Clinically Significant Changes in Electrocardiogram (ECG) Values measure: Number of Participants With Clinically Significant Changes in Vital Sign Parameters measure: Number of Participants With Clinically Significant Changes in Clinical Laboratory Assessments measure: Number of Participants With Clinically Significant Changes in Physical and Neurological Examination Results measure: Changes in Suicidality Assessed Using the Columbia Suicide Severity Rating Scale (C-SSRS) sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT hasResults: False
nctId: NCT06366230 id: 24-41450 briefTitle: Adding Urea to the Final Dialysis Fluid overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2028-06-30 date: 2028-06-30 date: 2024-04-15 date: 2024-04-15 name: University of California, San Francisco class: OTHER briefSummary: At times patients with advanced renal failure present with severe hyperkalemia or acidosis and very high serum blood urea nitrogen (BUN) concentrations. These patients cannot be dialyzed aggressively as the lowering of serum BUN may results in disequilibrium syndrome but on the other hand they need aggressive dialysis in order to lower their serum potassium or fix their severe acidosis. If one is able to add urea to the dialysis fluid, one can prevent the rapid lowering of serum BUN and osmolality at the same time as doing aggressive dialysis to lower serum potassium and/or fix the metabolic acidosis. conditions: Dysequilibrium Syndrome conditions: ESRD conditions: Hyperkalemia conditions: Metabolic Acidosis studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Urea in the dialysate measure: Disequilibrium measure: Serum potassium concentration measure: Serum CO2 concentration measure: Serum BUN concentration sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Zuckerberg San Francisco General Hospital city: San Francisco state: California zip: 94110 country: United States name: Ramin Sam, MD role: CONTACT phone: 628-206-6605 email: ramin.sam@ucsf.edu lat: 37.77493 lon: -122.41942 hasResults: False
nctId: NCT06366217 id: 20-32530A briefTitle: Efficacy of the MydCombi on Pupillary Dilation in Pediatric and Adult Patients overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-31 date: 2024-12-31 date: 2024-04-15 date: 2024-04-19 name: University of California, San Francisco class: OTHER briefSummary: To raise the standard of care, improve the overall patient experience and streamline practice flow, Eyenovia has developed an innovative mydriatic to be delivered as a microdose by a specialized dispenser. While still achieving effective pupil dilation, MydCombi has the potential to increase patient throughput at practicing offices by decreasing time spent eye dropping patients, eliminating time wasted waiting between drop instillations and ensuring more accurate drug delivery. The proposed study hopes to demonstrate the non-inferiority of using MydCombi to achieve pupillary dilation in patients compared to standard of care eye drops. conditions: Dilation conditions: Pupil Reaction Absent studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 100 type: ESTIMATED name: MydCombi Device name: MydCombi Drug measure: Percent change in Spherical equivalent measure: Percent Change in maximum pupil diameter measure: Percent Change in pupil constriction percentage measure: Percent Change in Intraocular Pressure sex: ALL minimumAge: 2 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: University of California, San Francisco city: San Francisco state: California zip: 94143 country: United States lat: 37.77493 lon: -122.41942 hasResults: False
nctId: NCT06366204 id: H23-03119 briefTitle: Lysine Requirements During Lactation overallStatus: RECRUITING date: 2024-01-01 date: 2025-03-31 date: 2025-12-31 date: 2024-04-15 date: 2024-04-15 name: University of British Columbia class: OTHER name: Canadian Institutes of Health Research (CIHR) briefSummary: The study aims to establish lysine requirements using the indicator amino acid oxidation (IAAO) method in women exclusively breastfeeding a single infant aged 3-4 months, and how maternal lysine needs change once infant transition to complimentary feeding at a later age of 9-10 months. Each 8-hour study day will have an assigned test lysine intake ranging from deficient to excess. The diets will be provided in a complete protein shake format, meeting all nutrient requirements except for the test lysine intake. Breath samples evaluate the indicator's oxidation to determine protein synthesis in response to lysine intake. Urine and one blood sample will be collected to assess metabolite concentrations. conditions: Lactation conditions: Breastfeeding, Exclusive conditions: Breastfeeding studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single day interventions; Repeated measures design. primaryPurpose: BASIC_SCIENCE masking: NONE count: 15 type: ESTIMATED name: Dietary Lysine Intakes measure: Carbon 13 Oxidation sex: FEMALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: BC Children's Hospital Research Institute status: RECRUITING city: Vancouver state: British Columbia zip: V5Z 4H4 country: Canada name: Taylor Bailey, BSc role: CONTACT phone: 705-698-7648 email: taylor.bailey@bcchr.ca name: Rajavel Elango, PhD role: PRINCIPAL_INVESTIGATOR lat: 49.24966 lon: -123.11934 hasResults: False
nctId: NCT06366191 id: 2023/CHU/08 briefTitle: Psychotrauma Prevention Algorithm : Randomized, Controlled Pilot Study acronym: A2P overallStatus: NOT_YET_RECRUITING date: 2024-10 date: 2025-04 date: 2025-07 date: 2024-04-15 date: 2024-04-15 name: Centre Hospitalier Universitaire de la Réunion class: OTHER briefSummary: A randomized pilot study which proposes to patients having suffered a traumatic event to have either only the standard care or the standard care associated with adaptated psychotrauma watch and prevention system. conditions: Psychological Trauma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 40 type: ESTIMATED name: prevention algorithm name: Standard care measure: study acceptability rate measure: Adherence of patient to the watch measure: Adherence of patient to the health watch measure: Patient satisfaction (quantitatif) measure: Patient satisfaction (qualitatif) measure: Strong points of the health watch measure: Evolution of the patient journey in experimental arm measure: Occurrence of post-traumatic stress disorder measure: Complications associated with post-traumatic stress disorder measure: Complications associated with post-traumatic stress disorder measure: Complications associated with post-traumatic stress disorder measure: Complications associated with post-traumatic stress disorder sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06366178 id: 2024/864 briefTitle: EPBONF : Evaluation of the Safety and Effectiveness of a Medical Device Aimed at Guiding Orbito-naso-frontal Band Surgery, for the Treatment of Craniostenoses acronym: EPBONF overallStatus: NOT_YET_RECRUITING date: 2024-12-01 date: 2026-12-01 date: 2026-12-01 date: 2024-04-15 date: 2024-04-15 name: Centre Hospitalier Universitaire de Besancon class: OTHER briefSummary: Craniostenosis is a congenital disorder caused by early fusion of the cranial sutures between the skull bones, resulting in orbito-naso-frontal deformities. The damage is primarily aesthetic, but intracranial hypertension may also be observed.
The aim of EPBONF research is to evaluate the benefits of using this template on the symmetry and angle of the BONF. conditions: Craniosynostoses studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 5 type: ESTIMATED name: BONFIX system measure: Evaluating the performance of the medical device, for orbito-naso-frontal bandeau surgery, in the treatment of craniostenosis: evaluation of efficacy on orbito-naso-frontal bandeau conformation, angle and symmetry criteria. measure: Evaluating the performance of the medical device, for orbito-naso-frontal bandeau surgery, in the treatment of craniostenosis: evaluation of efficacy on orbito-naso-frontal bandeau conformation, angle and symmetry criteria. measure: Evaluating the performance of the medical device, for orbito-naso-frontal bandeau surgery, in the treatment of craniostenosis: evaluation of efficacy on orbito-naso-frontal bandeau conformation, angle and symmetry criteria. sex: ALL minimumAge: 4 Months maximumAge: 24 Months stdAges: CHILD hasResults: False
nctId: NCT06366165 id: ACU-Med3 briefTitle: Linking Special Care Dentistry Curriculum to Seemingly Irrelevant Comedy overallStatus: RECRUITING date: 2021-10-01 date: 2021-10-01 date: 2024-08-30 date: 2024-04-15 date: 2024-04-15 name: Cairo University class: OTHER briefSummary: As Special care dentistry curriculum is very complicated and has a lot of details. Upon teaching it, the investigator will include memes and videos of movies and cartoons and will test the degree of retention of the information after years of passing the subject's exam. conditions: Learning Problem studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Testing the procedure of using a different mode of teaching medical content primaryPurpose: SCREENING masking: NONE count: 700 type: ESTIMATED name: seemingly irrelevant funny videos and memes in teaching measure: degree of retention of information sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Ahram Candian University status: RECRUITING city: Giza country: Egypt name: Ayat Gamal-AbdelNaser role: CONTACT phone: 01001874257 email: ayat.gamal@acu.edu.eg lat: 30.00808 lon: 31.21093 hasResults: False
nctId: NCT06366139 id: Trigeminal RFT vs max/mand PRF briefTitle: Trigeminal Ganglion RFT vs Maxillary/Mandibular PRF in the Treatment of Trigeminal Neuralgia overallStatus: COMPLETED date: 2023-01-11 date: 2024-02-04 date: 2024-03-07 date: 2024-04-15 date: 2024-04-15 name: Diskapi Teaching and Research Hospital class: OTHER briefSummary: Trigeminal ganglion (TG) radiofrequency thermocoagulation (RFT) and ultrasound (US)-guided maxillary or mandibular (max/mand) pulsed radiofrequency (PRF) are two interventional procedures for the treatment of trigeminal neuralgia (TN). The aim of this study was to compare the efficacy and safety of these two procedures. For this evaluation, the numeric rating scale (NRS) was used to assess pain relief and the Medication Quantification Scale III (MQS III) was used to assess the effectiveness of the interventions on medication consumption. The rates of adverse events related to the interventions were also compared. conditions: Trigeminal Neuralgia conditions: Headache Disorders studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 44 type: ACTUAL name: Radiofrequency thermocoagulation of the trigeminal ganglion name: Maxillary/Mandibular nerve pulsed radiofrequency measure: Numerical rating scale (NRS) measure: The Medication Quantification Scale III (MQS III) sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Diskapi Training and Research Hospital city: Ankara country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06366126 id: Child Abuse briefTitle: Long Term Impact of Child Abuse in University Students overallStatus: COMPLETED date: 2023-02-01 date: 2023-08-31 date: 2023-08-31 date: 2024-04-15 date: 2024-04-15 name: Delta University for Science and Technology class: OTHER briefSummary: Based on research and studies, a broad conceptualization of child abuse and neglect has progressively been constructed, defining it as all actions carried out by caregivers that significantly interfere in the child's optimum development and do not adhere to social standards. This conceptualization contemplates aspects such as neglecting physical-biological, cognitive, emotional, and social needs, and the different types of child maltreatment are also classified.
This study aimed too evaluate the psychological and social long-term effects of different types of child abuse. conditions: Child Abuse studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 242 type: ACTUAL measure: tailored questionnaire sex: ALL minimumAge: 18 Years maximumAge: 23 Years stdAges: ADULT facility: Amira Hussin Mohammed city: Gamasa zip: 35712 country: Egypt lat: 31.44112 lon: 31.53675 hasResults: False
nctId: NCT06366113 id: 2023-A00363-42 briefTitle: Time of Exercise Re-training With Chronic Obstructive Pulmonary Disease (COPD) acronym: CHRONOBIO overallStatus: RECRUITING date: 2024-01-02 date: 2024-01-02 date: 2024-07-01 date: 2024-04-15 date: 2024-04-17 name: Michaël RACODON class: OTHER briefSummary: Pulmonary rehabilitation (PR) is an effective intervention for reducing hospital readmissions, secondary events, and mortality in patients with respiratory pathologies.
The program should not be improved by introducing new subjects such as circadian rhythm. conditions: Respiratory Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 90 type: ESTIMATED name: Pulmonary rehabilitation measure: 6-minute walk test (6MWT) measure: Time limit test (Time-lim) measure: Sit to stand test (STT) measure: Single arm curl Test (SAC) measure: Single-leg stance test (SLT) measure: Hospital Anxiety and Depression Scale (HAD) measure: Pittsburgh Sleep Quality Index sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clinique la Mitterie status: RECRUITING city: Lille zip: 59130 country: France name: Michaël RACODON, PhD role: CONTACT phone: +33320223457 email: mracodon@clinique-mitterie.com lat: 50.63297 lon: 3.05858 hasResults: False
nctId: NCT06366100 id: 2023I060 briefTitle: Implementation of Two Transdiagnostic Interventions Based on Emotional Regulation (DBT and UP) for Alcohol Addiction overallStatus: RECRUITING date: 2024-02-01 date: 2025-06-30 date: 2025-12-31 date: 2024-04-15 date: 2024-04-15 name: Universidad de Zaragoza class: OTHER name: Ministerio de Sanidad, Servicios Sociales e Igualdad briefSummary: The aim of this study is to evaluate the dissemination and implementation process of two transdiagnostic psychological interventions (Dialectical Behavioral Therapy for Substance Use Disorders-DBT-SUD and Unified Protocol-UP) to treat alcohol addiction by mental health practitioners in the Spanish National Health System. The main questions this study aims to answer are:
The study comprises two phases. In the first phase, mental health professionals working on addiction services of the Spanish National Health System will be randomly assigned to receive training in one intervention and then the other (DBT-SUD and UP) and will be evaluated before and after each training. In the second phase, participants will be randomly assigned to implement one intervention first and then the other in their workplaces with people with alcohol addiction and will be also assessed before and after the implementation. Qualitative and quantitate outcome measures will be analyzed using a Mixed- Methods-Design. conditions: Implementation Science studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants are assigned to two groups in parallel for the duration of the study. The specific design is an reverse counterbalanced (ABBA) intrasubject experimental study where participants will be randomly assigned to first (and then the other) receive DBT-SUD or UP online training in the phase 1 of the study, and randomly assigned to first implement DBT-SUD or UP intervention in the phase two. A balanced randomization (1:1) will be conducted in order to eliminate possible biases and ensure equivalence between groups. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 160 type: ESTIMATED name: Dialectical Behavior Therapy for Substance Use Disorder (DBT-SUD) name: Unified Protocol (UP) measure: Acceptability and Intention to Use Survey measure: Measures of Acceptability, Appropriateness and Feasibility of the intervention (AIM, IAM & FIM) measure: Normalization MeAsure Development Questionnaire (NoMAD) measure: Copenhagen Burnout Inventory (CBI) measure: Brief Scale of Understanding Substance Abuse (SUSS) measure: Implementation Climate Scale (ICS) measure: Organizational Readiness for Implementing Change (ORIC) measure: Evidence-Based Practice Attitudes Scale (EBPAS) measure: Program sustainability assessment tool (PASAT) measure: Barriers to Implementation Inventory (BTI) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Zaragoza status: RECRUITING city: Teruel state: Aragón zip: C/ Ciudad Escolar S/N44003 country: Spain name: María Vicenta Navarro Haro, PhD role: CONTACT phoneExt: 861145 email: mvnavarro@unizar.es lat: 40.3456 lon: -1.10646 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-04-02 uploadDate: 2024-04-09T12:23 filename: ICF_000.pdf size: 419669 hasResults: False
nctId: NCT06366087 id: BP-C-24-001 briefTitle: Sublingual Atropine Bioequivalence by Route of Administration (SABER) acronym: SABER overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-05-24 date: 2024-05-24 date: 2024-04-15 date: 2024-04-15 name: Biomedical Advanced Research and Development Authority class: FED name: Rho Federal Systems Division, Inc. name: Allucent briefSummary: A randomized, two-period, two-sequence, crossover study to assess the bioequivalence, bioavailability, and pharmacokinetics (PK) of a single dose of atropine administered sublingually (SL) or intramuscularly (IM) in healthy adult volunteers. conditions: Atropine Bioequivalence studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 46 type: ESTIMATED name: Atropine Sulfate Ophthalmic Solution USP, 1% name: Atropine Sulfate Injection, USP 8 mg/20 mL (0.4 mg/mL) measure: The bioequivalence of atropine sulfate administered SL versus administered IM as measured by area under the analyte concentration versus time curve to infinity (AUCinf). measure: The bioequivalence of atropine sulfate administered SL versus administered IM as measured by area under the analyte concentration versus time curve to time of last quantifiable data point (AUCt). measure: The relative bioavailability of atropine sulfate administered SL versus IM as measured by area under the analyte concentration versus time curve to time 45, 60, 90, 120, 150, and 240 minutes (AUC45, AUC60, AUC90, AUC120, AUC150, and AUC240, respectively) measure: The relative bioavailability of atropine sulfate administered SL versus IM as measured by maximum measured plasma concentration (Cmax) measure: The relative bioavailability of atropine sulfate administered SL versus IM as measured by time to Cmax (tmax) measure: The relative bioavailability of atropine sulfate administered SL versus IM as measured by apparent terminal elimination half-life (t1/2) measure: The relative bioavailability of atropine sulfate administered SL versus IM as measured by terminal elimination rate constant (λz) measure: The relative bioavailability of atropine sulfate administered SL versus IM as measured by volume of distribution (Vd/F) measure: The relative bioavailability of atropine sulfate administered SL versus IM as measured by total body clearance (CL/F) measure: The relative bioavailability of atropine sulfate administered SL versus IM as measured by absorption rate constant (Ka) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Johnson County Clin-Trials (JCCT) city: Lenexa state: Kansas zip: 66219 country: United States name: Carlos A Fierro, MD role: CONTACT phone: 913-825-4400 email: cfierro@jcct.com name: Mazen Zari role: CONTACT phone: 913-825-4400 email: mzari@jcct.com name: Carlos A Fierro, MD role: PRINCIPAL_INVESTIGATOR lat: 38.95362 lon: -94.73357 hasResults: False