hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06338202 id: CV027-1137 briefTitle: Real-World Effectiveness of Mavacamten in Canada acronym: MAVEN overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-08-31 date: 2024-08-31 date: 2024-03-29 date: 2024-03-29 name: Bristol-Myers Squibb class: INDUSTRY briefSummary: The purpose of this observational, retrospective, physician survey study is to describe the real-world effectiveness and use of mavacamten in participants who initiated treatment for obstructive hypertrophic cardiomyopathy (oHCM) in Canada. conditions: Obstructive Hypertrophic Cardiomyopathy (oHCM) studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 100 type: ESTIMATED name: Mavacamten measure: Change in New York Heart Association (NYHA) functional class following mavacamten treatment initiation measure: Change in left ventricular outflow tract (LVOT) with Valsalva maneuver (vLVOT) gradient following mavacamten treatment initiation measure: Proportion of patients with left ventricular outflow tract (LVOT) with Valsalva maneuver gradient (vLVOT) < 20mmHg following mavacamten treatment initiation measure: Age measure: Sex at birth measure: Ethnicity measure: Employment status measure: Body mass index (BMI) measure: Obstructive hypertrophic cardiomyopathy (oHCM) disease duration measure: Proportion of patients in each New York Heart Association (NYHA) functional class II and III measure: Left ventricular outflow tract (LVOT) with Valsalva maneuver (vLVOT) gradient measure: Left ventricular ejection fraction by 2D echocardiogram (LVEFb) measure: Mavacamten dose regimen measure: Proportion of patients who discontinued mavacamten measure: Duration of treatment prior to mavacamten discontinuation measure: Left ventricular ejection fraction by 2D echocardiogram (LVEF) at the time of mavacamten treatment discontinuation measure: Proportion of patients with left ventricular ejection fraction by 2D echocardiogram (LVEF) < 50% at the time of mavacamten treatment discontinuation measure: Reason for discontinuing mavacamten treatment measure: Functional assessment schedule sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: London Health Science Centre (LHSC) city: London state: Ontario zip: N6A 5A5 country: Canada lat: 42.98339 lon: -81.23304 hasResults: False
nctId: NCT06338189 id: USuffolk briefTitle: The 5Ad Diet for Functional Bowel Disorders overallStatus: RECRUITING date: 2022-05-08 date: 2025-04-01 date: 2026-04-01 date: 2024-03-29 date: 2024-03-29 name: University of Suffolk class: OTHER briefSummary: The goal of this randomised controlled trial (RCT) is to compare the efficacy of the newly developed 5Ad diet against the widely researched low fermentable oligo-, di-, monosaccharide and polyols (FODMAP) diet in reducing gastrointestinal symptoms associated with functional bowel disorders/food intolerances.
Researchers will compare the results from the 2 dietary protocols in order to ascertain the superiority of one over the other in regards to 6 gastrointestinal symptoms (abdominal pain, bloating, flatulence, bowel urgency, straining and incomplete defecation), stool form and frequency of defecation. conditions: Functional Bowel Disorder conditions: Irritable Bowel Syndrome conditions: Food Intolerance conditions: Food Intolerance Syndromes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: The 5Ad Diet name: The Low FODMAP Diet measure: Abdominal Pain measure: Abdominal Bloating measure: Flatulence measure: Bowel Urgency measure: Straining measure: Incomplete Defecation measure: Stool Form measure: Frequency of defecation measure: Fatigue measure: Mental Fatigue measure: Physical Fatigue sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Suffolk status: RECRUITING city: Ipswich state: Suffolk zip: IP4 1QJ country: United Kingdom name: Camilla Bunn role: CONTACT phone: +44 1473 338332 email: c.bunn2@uos.ac.uk name: Dr Fandi Ibrahim role: CONTACT phone: +44 1473 338623 email: f.ibrahim@uos.ac.uk name: Camilla Bunn role: PRINCIPAL_INVESTIGATOR name: Dr Fandi Ibrahim role: SUB_INVESTIGATOR name: Dr Federica Masieri role: SUB_INVESTIGATOR name: Martin Sinclair role: SUB_INVESTIGATOR lat: 52.05917 lon: 1.15545 hasResults: False
nctId: NCT06338176 id: Pro00128904 briefTitle: Optimizing the Management of Staphylococcus Aureus Bacteremia (OPTIMUS-SAB) overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-10-30 date: 2026-04-30 date: 2024-03-29 date: 2024-04-22 name: University of Alberta class: OTHER name: Alberta Health services briefSummary: Staphylococcus aureus bacteremia (SAB) is associated with high morbidity and mortality rates with an incidence disproportionately higher in vulnerable populations. Management according to evidence-based care parameters, in particular Infectious Diseases (ID) consultation, is associated with improved mortality. SAB management is suboptimal in Alberta compared to other jurisdictions. An Alberta-based pilot study confirmed that timely recommendations to optimize SAB care, including ID consultation, was associated with improved adherence to all evidence-based quality-of-care indicators.
Leveraging this pilot work, the investigators aim to implement OPTIMUS-SAB, an enhanced model of the pilot, to optimize and standardize SAB management across Alberta. The implementation study will be a zone-based acute care site stepped wedge design. OPTIMUS-SAB will consist of a centralized SAB care team whom will receive automated notification of all blood cultures positive for S. aureus allowing them to review the patient's medical chart and make preliminary management recommendations according to an evidence-based care bundle.
The investigators will evaluate adherence to evidence-based SAB quality-of-care indicators before and after OPTIMUS-SAB implementation and expect this to improve with a resultant reduction in duration of bacteremia, length of stay, readmission rates, and mortality. In turn, this will translate into cost savings for the health care system. conditions: Staph Aureus Bacteremia studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 1800 type: ESTIMATED name: OPTIMUS-SAB clinical care pathway measure: Adherence to quality-of-care indicators measure: Length of stay measure: Hospital re-admission rates measure: All-cause mortality measure: In hospital mortality measure: Costing evaluation measure: Implementation evaluation sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06338163 id: POSSIBLE 1.6 briefTitle: Polihexanide SSIs Measures Bundle (PSMB) During Enhanced Recovery After Major Digestive Surgery acronym: POSSIBLE overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-06-30 date: 2025-09-30 date: 2024-03-29 date: 2024-04-04 name: Marco Catarci class: OTHER name: Associazione Chirurghi Ospedalieri Italiani briefSummary: This is a randomized controlled, prospective, multicenter superiority trial with two parallel treatment groups and single blinding (local investigators performing postoperative follow up will be blinded for group allocation), with prospective enrollment planned from July 2024 to June 2025 in 20 Italian surgical centers. All patients undergoing elective major gastro-intestinal (GI) tract surgery (upper GI, HPB, \& lower GI) will be included in a prospective database after written informed consent. A total of 2,000 patients is expected based on a mean of 100 cases per center. conditions: Surgical Site Infection conditions: Surgical Procedures, Operative studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized controlled prospective multicenter primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Assessor of the primary outcome will be masked concerning arm allocation whoMasked: OUTCOMES_ASSESSOR count: 2000 type: ESTIMATED name: Polihexanide-based bundle name: Standard bundle measure: Surgical Site Infections rate measure: Incisional (superficial and deep) Surgical Site Infections rate measure: Infectious morbidity rates measure: Anastomotic leakage rates measure: Overall morbidity rates measure: Major morbidity rates measure: Comprehensive complication index measure: Overall length of postoperative hospital stay measure: Readmission rates measure: Patient-reported outcome measures sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: OSpedale Santa Maria Annunziata city: Firenze state: FI zip: 50012 country: Italy name: Marco Scatizzi, MD role: CONTACT phone: 393474137246 email: marcoscatizzi@gmail.com lat: 43.77925 lon: 11.24626 facility: Ospedale Civile di Macerata city: Macerata state: MC zip: 62100 country: Italy name: Massimo Sartelli, MD role: CONTACT phone: +393405369701 email: massimosartelli@gmail.com lat: 43.29789 lon: 13.45293 facility: Ospedale Sandro Pertini city: Roma state: RM zip: 00157 country: Italy name: Marco Catarci, MD role: CONTACT phone: +393298610040 email: marco.catarci@aslroma2.it name: Michele Benedetti, MD role: SUB_INVESTIGATOR name: Paolo Ciano, MD role: SUB_INVESTIGATOR lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06338137 id: 4-2024urol briefTitle: Comparison of High and Low Pulse Energy Dusting Protocols Using Holmium: YAG-laser in Flexible Ureteroscopy for Renal Stones Treatment overallStatus: COMPLETED date: 2022-08-25 date: 2023-08-25 date: 2024-01-01 date: 2024-03-29 date: 2024-04-04 name: Menoufia University class: OTHER briefSummary: Rcompare high-energy versus low-energy laser settings in renal stone lithotripsy using low power machines) Holmium YAG 30 watts, examining their respective advantages, limitations, and overall efficacy. conditions: Renal Stone studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 160 type: ACTUAL name: Holmium Yag laser measure: Stone free rates measure: Preoperative complications sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hossam Kandeel city: Shibīn Al Kawm state: State Or Province zip: 32511 country: Egypt lat: 30.55258 lon: 31.00904 hasResults: False
nctId: NCT06338124 id: David Ibrahim briefTitle: Value of Laboratory Biomarkers in Prediction of Outcome in Septic Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-03-15 date: 2025-04-01 date: 2024-03-29 date: 2024-03-29 name: Egymedicalpedia class: INDUSTRY briefSummary: Sepsis is defined as a dysregulated host response to infection . Despite ongoing efforts, both the incidence and mortality of sepsis have demonstrated limited reductions over the past years,There are several biomarkers that have already been studied for the early diagnosis of sepsis. Some of these markers can be used in risk prediction and monitoring the outcome of sepsis .
Some of these markers as procalcitonin and CD14, are costly and not feasible options for low- and middle-income countries . While other biomarkers are feasible and accessible to be evaluated as Triglyceride\\glucose index (TyG) , Relative Distributive Width of red blood corpuscles to albumin ratio (RAR), C-reactive protein,Neutrophile \\Lympocyte ratio and serum lactate levels . conditions: Sepsis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Triglyceride glucose index measure: Mortality sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Assuit University Hospital city: Assiut country: Egypt name: Dina Hamad, Assist.Prof role: CONTACT phone: +201063040703 email: dinaalihamad@yahoo.com lat: 27.18096 lon: 31.18368 hasResults: False
nctId: NCT06338111 id: 2461 briefTitle: Interventions Meant to Improve the Outcome of Critical Care Patients in the ED overallStatus: COMPLETED date: 2020-11-09 date: 2022-12-06 date: 2023-04-30 date: 2024-03-29 date: 2024-04-16 name: Iuliu Hatieganu University of Medicine and Pharmacy class: OTHER briefSummary: This study aims to identify the prognostic role of procalcitonin (PCT), soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), the soluble form of the urokinase plasminogen activator receptor (suPAR), highly sensitive C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and azurocidin 1 (AZU1) in 28-day mortality for patients with sepsis in Emergency Department. conditions: Sepsis Syndrome conditions: Emergency Department conditions: Biomarker studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 67 type: ACTUAL name: ELISA Sepsis Biomarkers dosage measure: Can we better predict mortality in septic patients from the Emergency Department? sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cluj County Hospital Emergency Department city: Cluj-Napoca state: Cluj zip: 400006 country: Romania lat: 46.76667 lon: 23.6 hasResults: False
nctId: NCT06338098 id: HFNVSH.001 briefTitle: Effect of an 8-week Heartfulness Meditation Program on Burnout and Stress at Veterinary Specialty Hospital overallStatus: COMPLETED date: 2023-02-28 date: 2023-10-02 date: 2023-10-02 date: 2024-03-29 date: 2024-04-02 name: Heartfulness Institute class: OTHER name: Angell Animal Medical Center briefSummary: This quantitative study assesses the effects of meditation and relaxation practices on the reduction of burnout and stress in veterinary care workers. Assessments at baseline will include the Perceived Stress Scale (PSS) and Maslach Burnout Toolkit, and the same questionnaires were collected in Week 8 and Week 16. The Google form questionnaire will ask the participant for their email address. The form will also include a question eliciting interest in participation in the 8-weeks Heartfulness Meditation program. The program will include tools that promote a heart-based nurturing environment focusing on relaxation, and tools to cope with burnout. conditions: Stress conditions: Burnout, Professional studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 74 type: ACTUAL name: 8-week wellness and relaxation meditation program measure: Assess the current level of Anxiety measure: Changes level of Stress measure: Assess the current level of Burnout measure: Changes level of Burnout sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Angell Animal Medical Center, city: Boston state: Massachusetts zip: 02130 country: United States lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06338085 id: meryemvrlshn00000000002 briefTitle: The Effect of Emotional Freedom Technique (EFT) on Depression in Postmenopausal Women overallStatus: RECRUITING date: 2024-03-11 date: 2024-05-04 date: 2024-05-20 date: 2024-03-29 date: 2024-04-05 name: Meryem Vural Şahin class: OTHER briefSummary: The aim of this study is to determine the effect of EFT (Emotional Freedom Technique), a nonpharmacological method, on menopausal symptoms and depression in postmenopausal women. By determining the effectiveness of the Emotional Freedom Technique, the applicability of non-pharmacological method treatment in women with depression and menopausal symptoms in postmenopausal period will be proven. As a result of the study, if a positive effect on menopausal symptoms and depression is found in women with EFT, it can be recommended as an evidence-based alternative method in midwifery and nursing care. conditions: Menopause studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: the groups with a conventional therapy control group primaryPurpose: TREATMENT masking: NONE count: 80 type: ESTIMATED name: emotional liberation technique measure: Beck Depression Scale measure: Menopause Rating Scale (MRS) sex: FEMALE maximumAge: 65 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: family health center no. 1 in Çayyolu status: RECRUITING city: Ankara state: Çankaya country: Turkey name: MERYEM VURAL ŞAHİN role: CONTACT phone: 05535344779 email: meryemyasam@gmail.com name: Meltem UĞURLU role: PRINCIPAL_INVESTIGATOR name: Derya Yüksel KOÇAK role: SUB_INVESTIGATOR lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06338072 id: DIABETEXX/1 briefTitle: Impact of the Menstrual Cycle in Reproductive Aged Women With Type 1 Diabetes Using a Closed Loop System (DIABETEXX/1). acronym: DIABETEXX/1 overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-03 date: 2025-01-01 date: 2025-08-01 date: 2024-03-29 date: 2024-04-23 name: Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal class: OTHER name: Universitat Politècnica de València briefSummary: The aim of this observational study is to assess the effectiveness of automatic insulin infusion in responding to changes in insulin sensitivity throughout various phases of the menstrual cycle in a cohort of reproductive-aged women with type 1 diabetes, using an advanced closed-loop system. By gaining insights into both the limitations and effectiveness of this adaptation, we aim to inform the enhancement of control algorithms and learning strategies within closed-loop systems. This research is especially vital for addressing the distinct challenges that women commonly encounter in maintaining glycemic control. conditions: Type 1 Diabetes studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 119 type: ESTIMATED measure: Time in range measure: Time below range measure: Time above range measure: Caloric intake measure: Temperature measure: Photoplethysmography measure: Accelerometry sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Lía Nattero-Chávez city: Madrid zip: 28034 country: Spain lat: 40.4165 lon: -3.70256 hasResults: False
nctId: NCT06338059 id: Gulcanozturkchatipchousein briefTitle: Relationship Between Vitamin D and Vitamin B12 Levels and Neuropathic Pain in Lipedema overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-01 date: 2024-05-01 date: 2024-06-01 date: 2024-03-29 date: 2024-03-29 name: Fatih Sultan Mehmet Training and Research Hospital class: OTHER briefSummary: Lipedema is a disease characterized by bilateral abnormal fat deposition in the upper and lower extremities. Pain is a common symptom in lipedema.Vitamin D plays an important role in chronic pain. Vitamin B have analgesic role in some neuropathic pain conditions.This study aimedto evaluate the relationship between vitamin D and vitamin B12 levels and neuropathic pain in lipedema. conditions: Vitamin D Deficiency conditions: B12 Deficiency Vitamin conditions: Lipedema studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 200 type: ACTUAL name: Vitamin B12 Level measure: Vitamin B12 Level measure: 25 OH Vitamin D Level sex: FEMALE minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Gulcan Ozturk city: Istanbul zip: 34752 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06338046 id: EAShi23M01 briefTitle: In Vivo Evaluation of NC65 - Vita D-Light SKIN ADAPTOGEN AND SEBUM BALANCE EFFICACY acronym: Shitake overallStatus: COMPLETED date: 2023-10-01 date: 2023-11-15 date: 2023-12-22 date: 2024-03-29 date: 2024-03-29 name: Ritamaria Di Lorenzo class: OTHER briefSummary: This double-blind placebo-controlled study intends to confirm skin adaptogen and sebum balance efficacy of the investigational active ingredient NC65 - Vita D-Light, transmitted at 0.5% w/w in a topical cosmetic formulation, on a panel of healthy human subjects.
The study is performed by RD Cosmetics - University of Naples Federico II, from October to June 2024. The study involves female and male subjects, scheduled for eligibility screening at the study site. A total of 40 subjects were enrolled, and randomly divided into 2 groups: 20 subjects received the active treatment (cosmetic formulation with 0.5 %w/w NC65 - Vita D-Light) and 20 subjects the placebo one.
The monitored skin features parameters will be check after 1 hour (T1h) for the adaptogen test, and after 7, 14 and 28 days (T7 -T14-T28), for the detox test. Panelists will complete the self-assessment questionnaire at the end of the study period (T28). conditions: SKIN ADAPTOGEN AND SEBUM BALANCE EFFICACY studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 2 parallel arm, double blind, randomized, placebo-controlled primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: neither the patient nor the investigator knows who is getting which treatment. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 40 type: ACTUAL name: Corthellus Shiitake(Mushroom) Extract name: Placebo measure: Soothing Test measure: Detox and adaptogen Test sex: ALL minimumAge: 25 Years maximumAge: 40 Years stdAges: ADULT facility: RD Cosmetics Lab - Pharmacy Department, University of Naples Federico II city: Naples zip: 80131 country: Italy lat: 40.85216 lon: 14.26811 hasResults: False
nctId: NCT06338033 id: 2024-03-23 briefTitle: Prognostic Study of Visceral Fat and Heart Failure With Preserved Ejection Fraction overallStatus: COMPLETED date: 2020-09-19 date: 2023-08-28 date: 2023-11-30 date: 2024-03-29 date: 2024-03-29 name: Chongqing Medical University class: OTHER briefSummary: Obesity and heart failure with preserved ejection fraction (HFpEF) have multiple pathologic associations that affect the prognosis of HFpEF. Chinese people are more prone to visceral obesity, resulting in varying degrees of true obesity in individuals with the same body mass index (BMI). There are no prognostic studies of VFA/BMI in the HFpEF population. conditions: Heart Failure With Preserved Ejection Fraction and Visceral Fat studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 298 type: ACTUAL measure: All-cause mortality measure: Rehospitalization for heart failure measure: Composite endpoints of all-cause mortality and rehospitalization for heart failure sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The First Affiliated Hospital of Chongqing Medical University city: Chongqing country: China lat: 29.56278 lon: 106.55278 hasResults: False