hackint0sh/New-Dataset huggingface dataset:
With funding from the Dutch National Agenda for Suicide Prevention, a contextualized replication study is conducted. The aim of this study is to determine whether the #Chatsafe intervention has an effect on the way in which Dutch YP communicate online about suicide. conditions: Suicide Prevention conditions: Communication conditions: Social Media studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants are randomized to the intervention or the control group using block randomization with varying block sizes (block sizes vary from 2 to 16). The distribution key will be 1:1. The randomization schedule is computer generated by a researcher who will not be part of the analysing researchers. primaryPurpose: PREVENTION masking: SINGLE maskingDescription: The research team will be kept blind to randomization. A safety procedure is drawn up in which a senior researcher is appointed who will be unblinded if absolutely necessary. Principally, this will not be needed, since the study psychologists are independently alerted when a subject wants to get in touch. whoMasked: INVESTIGATOR count: 400 type: ESTIMATED name: Social Media campaign measure: Safe communication about suicide online measure: Confidence when communicating about suicide online measure: Willingness to intervene against suicide online measure: Self-efficacy online measure: Safety of the #ChatsafeNL materials measure: Acceptability of the #ChatsafeNL intervention measure: Safety of the #ChatsafeNL intervention sex: ALL minimumAge: 16 Years maximumAge: 25 Years stdAges: CHILD stdAges: ADULT facility: 113 Suicide Prevention city: Amsterdam state: Noord Holland zip: 1105 BP country: Netherlands name: Elke Elzinga, dr role: CONTACT phone: 020 3113883 email: e.elzinga@113.nl name: Saskia Mérelle, dr role: CONTACT phone: 020 3113883 email: s.merelle@113.nl lat: 52.37403 lon: 4.88969 hasResults: False
nctId: NCT06364319 id: 2024PHD002-001 briefTitle: Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory cGVHD overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2027-12-31 date: 2028-06-30 date: 2024-04-15 date: 2024-04-15 name: Peking University People's Hospital class: OTHER briefSummary: The study plan aims to include patients who have been diagnosed with steroid-refractory chronic GVHD in the liver following allogeneic hematopoietic stem cell transplantation. After obtaining informed consent, the patients will be randomly assigned to either the Anti-CD25 rhMAb treatment group or the traditional treatment group. The objective is to assess the effectiveness and safety of Anti-CD25 rhMAb in the treatment of severe chronic GVHD affecting the liver. conditions: cGVHD studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 118 type: ESTIMATED name: anti-CD25 rhMAb name: Prednisone name: Ruxolitinib name: Cyclosporine measure: overall response rate (ORR) measure: duration of response（DOR） measure: patient-reported outcomes (PRO) measure: disease-free survival (DFS) measure: failure-free survival (FFS) measure: non-relapse mortality (NRM) measure: overall survival （OS） measure: adverse drug reactions (ADR) sex: ALL minimumAge: 16 Years maximumAge: 65 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06364306 id: 12032024 briefTitle: oPen Versus RobotIc retrOmuscular Repair in Medium to Large Ventral Hernias acronym: PRIOR overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-12-31 date: 2031-12-31 date: 2024-04-15 date: 2024-04-17 name: University Hospital, Basel, Switzerland class: OTHER name: St. Clara Hospital, Basel, Switzerland name: Klinikum Kempten, Kempten, Germany briefSummary: This study investigates on the effect of two different operative techniques to treat large abdominal wall defects.
Either be operated using the RVHR or OVHR will be followed up either in person or via email / phone call at day 7, day 30, 6 months, 1, 3 and 5 years after the surgery to asses the above-stated main and some more outcomes. conditions: Ventral Hernia conditions: Incisional Hernia conditions: Abdominal Wall Defect studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Patients are blinded to their treatment allocation until hospital discharge criteria according to the primary endpoint are fulfilled. After discharge, blinding is difficult to be ensured because there is no control, if dressing have been removed or modified. To ensure patient blinding during hospital stay, patients from both treatment arms will receive identical dressings as if an open and minimal-invasive access had been performed. In case the dressing must be changed during the hospital stay, this will be performed while the patient is blinded using a cover.
In case for any reason the patient has been unblinded to his treatment allocation (accidental or intentional dressing removal, bed-side wound opening, other) all outcome data are assessed regardless and unblinding is documented and reported in the final report. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 140 type: ESTIMATED name: Robotically-assisted ventral hernia repair (RVHR) name: Open ventral hernia repair (OVHR) measure: Primary outcome: length of stay measure: Comprehensive complication index (CCI) measure: Adverse events measure: pain after surgery measure: Functional recovery measure: Quality of life using SF-12 form sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06364293 id: KY2023-261-01 briefTitle: An Early Warning Model of Unfavorable Outcomes Following Endovascular Interventional Treatment of Intracranial Aneurysm overallStatus: ENROLLING_BY_INVITATION date: 2024-01-01 date: 2026-12-31 date: 2026-12-31 date: 2024-04-15 date: 2024-04-15 name: Beijing Tiantan Hospital class: OTHER name: National Natural Science Foundation of China briefSummary: Endovascular treatment has become one of the primary treatment methods for intracranial aneurysms. The unfavorable outcomes during follow-up included aneurysm recurrence and long-term incomplete-occlusion, which would bring a high risk of rebleeding and retreatment. Previous studies have tried to predict the outcomes of aneurysms following endovascular treatment based on aneurysm characteristics including morphology, embolization packing degree, etc, but the conclusion was inconsistent. Hemodynamics of aneurysms and parent artery played a greater role in predicting outcomes following endovascular treatments. Investigators also found that the outcomes were determined by many factors, in which the demography, clinical indicators, treatment methods, and material selection can not be ignored, and the mechanism of unfavorable imaging outcomes should be explored using large samples of clinical cases and numerous variable parameters. The pre-experiment of investigators confirmed that artificial intelligence technology can meet the calculation requirements for deep mining and analysis of large sample data. This study aims to use the deep learning model to identify relevant risk factors and weights, establish a stable and accurate prediction model, then incorporate the prospective study to verify the model. The results will be very helpful in accurately predicting the adverse outcomes such as recurrence and long-term non-occlusion after endovascular treatment and help to improve the therapeutic strategy and avoid risk factors. Besides, the occurrence of ischemic or hemorrhagic complications during follow-up may affect the final follow-up outcome, so the analysis was included as one of the outcome events to evaluate the prognosis after intervention. conditions: Intracranial Aneurysm studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 750 type: ESTIMATED name: Observational design does not include interventional behavior. measure: Unfavorable imaging outcome measure: Hemorrhagic or ischemic complication occurred during the follow-up sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beijing Tiantan hospital city: Beijing country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06364280 id: 2023X0135 id: UG3HL165019 type: NIH link: https://reporter.nih.gov/quickSearch/UG3HL165019 id: U24HL165014 type: NIH link: https://reporter.nih.gov/quickSearch/U24HL165014 briefTitle: Pediatric Prehospital Airway Resuscitation Trial acronym: Pedi-PART overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2029-08-31 date: 2029-09-30 date: 2024-04-15 date: 2024-04-15 name: Ohio State University class: OTHER name: National Heart, Lung, and Blood Institute (NHLBI) name: University of Utah briefSummary: This study is a Phase 3, multi-center, Bayesian Adaptive Sequential Platform Trial testing the effectiveness of different prehospital airway management strategies in the care of critically ill children. Emergency Medical Services (EMS) agencies affiliated with the Pediatric Emergency Care Applied Research Network (PECARN) will participate in the trial. The study interventions are strategies of prehospital airway management: \[BVM-only\], \[BVM followed by SGA\] and \[BVM followed by ETI\]. The primary outcome is 30-day ICU-free survival. The trial will be organized and executed in two successive stages. In Stage I of the trial, EMS personnel will alternate between two strategies: \[BVM-only\] or \[BVM followed by SGA\]. The \[winner of Stage I\] will advance to Stage II based upon results of Bayesian interim analyses. In Stage II of the trial, EMS personnel will alternate between \[BVM followed by ETI\] vs. \[Winner of Stage I\]. conditions: Heart Arrest, Out-Of-Hospital conditions: Wounds and Injuries conditions: Respiratory Insufficiency in Children conditions: Child, Only conditions: Critical Illness studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The trial uses a Bayesian Adaptive Sequential Platform Trial (BASIC-PT) framework.
The trial will be organized and executed in two successive stages. In Stage I of the trial, EMS personnel will alternate between two strategies: \[BVM-only\] or \[BVM followed by SGA\]. The \[winner of Stage I\] will advance to Stage II based upon results of Bayesian interim analyses. In Stage II of the trial, EMS personnel will alternate between \[BVM followed by ETI\] vs. \[Winner of Stage I\].
nctId: NCT06364267 id: BabyTears briefTitle: Babytam vs Babyexe in Post-menopausal Women at High Risk for Breast Cancer. acronym: BabyTears overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2026-09-01 date: 2026-09-01 date: 2024-04-15 date: 2024-04-15 name: Andrea DeCensi class: OTHER name: Dana-Farber/Brigham and Women's Cancer Center name: Herbert Irving Comprehensive Cancer Center name: Istituto Europeo di Oncologia name: Breast Cancer Research Foundation briefSummary: The purpose of the study is to determine if 6 and 12 months of treatment with Tamoxifen at lower dose is superior to Exemestane at lower dose on quality of life. conditions: Breast Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 160 type: ESTIMATED name: Tamoxifen 10 MG name: Exemestane 25 MG measure: Quality of life MEnQol measure: Other domains measure: PMAS questionnaire measure: Customer Satisfaction questionnaire measure: BPI measure: Sex hormones biomarkers measure: Insulin biomarker measure: Bone biomarker sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: E.O. Ospedali Galliera city: Genova zip: 16128 country: Italy lat: 44.40478 lon: 8.94438 hasResults: False
nctId: NCT06364254 id: 2311054791 briefTitle: Effects of CBD on 2 Mile Run Time Trial Performance overallStatus: RECRUITING date: 2023-11-11 date: 2024-05-30 date: 2024-05-30 date: 2024-04-15 date: 2024-04-15 name: University of Northern Colorado class: OTHER briefSummary: Individuals who engage in endurance events tend to experience higher levels of stress within the body, mind, and gut, that often lead to impairment of performance. Based on previous studies, CBD has the potential relieve gut distress, and reduce pre-race anxiety thus resulting in an improvement in sport performance. Given the current research on the use of CBD in active individuals, the aim of this pilot study is to explore the effects of CBD compared to a placebo on anxiety, GI distress and a 2-mile running performance in a moderately active population identifying as female. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 30 type: ESTIMATED name: Cannabidiol Capsules measure: Difference in Time Trial Times measure: Difference in Anxiety Measured with the State Trait Anxiety Inventory measure: Difference in Blood Lactate Concentrations measure: Difference in Gastrointestinal Distress measure: Different in Heart Rate Variability sex: FEMALE minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: University Of Northern Colorado status: RECRUITING city: Greeley state: Colorado zip: 80639 country: United States name: Laura K Stewart, PhD role: CONTACT phone: 970-351-1891 email: laura.stewart@unco.edu lat: 40.42331 lon: -104.70913 hasResults: False
nctId: NCT06364241 id: 331760 id: 226706/Z/22/Z type: OTHER_GRANT domain: Wellcome Trust briefTitle: Focus Groups on Cognitive Function in Psychosis acronym: PRECOGNITION overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2024-07 date: 2026-09 date: 2024-04-15 date: 2024-04-15 name: King's College London class: OTHER name: South London and Maudsley NHS Foundation Trust briefSummary: Cognitive deficits are commonly observed in people with mental disorders. In psychosis, these impairments are frequently present early in the course of the disorder and have a substantial impact on functional outcomes. This project will gain insight into the cognitive deficits that people with lived experience of psychosis and their carers perceive to be the most troublesome. To achieve this, the investigators will conduct two sets of focus groups. During the first set of focus groups, the investigators will aim to identify the cognitive deficits that individuals with psychosis and their carers consider to be the most impairing.
Each participant will be asked to attend one focus group, which will last approximately one hour. Focus groups will take place at the South London and Maudsley (SLaM) Trust or at the Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, although provision will be made for participants to also participate online. conditions: Psychosis studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 32 type: ESTIMATED name: Focus group measure: Individual perception of impairments due to cognitive deficits associated with psychosis sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06364228 id: 0133-24-FB briefTitle: Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2026-04 date: 2026-04 date: 2024-04-15 date: 2024-04-15 name: University of Nebraska class: OTHER briefSummary: The proposed study is a double-blind, randomized, placebo-controlled study of intranasal oxytocin (OXT) to determine its efficacy in improving quality of life and reducing stress in caregivers to persons with dementia. Planned enrollment is 32 subjects over 2 years. conditions: Stress studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 32 type: ESTIMATED name: Placebo name: Oxytocin Intranasal Spray 12 International Unit (12IU) name: Oxytocin Intranasal Spray 24 International Unit (24IU) name: Functional MRI measure: Participants' chronic stress levels in the past thirty days. measure: Participant Quality of Life survey measure: Blood Oxygen Level Dependent (BOLD) responses in neural areas during the Affective Stroop task (AS) and EmpaTom task. sex: FEMALE minimumAge: 50 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Nebraska Medical Center, Department of Psychiatry city: Omaha state: Nebraska zip: 61898-5581 country: United States name: Minjoo Kang, MEd role: CONTACT phone: 402-552-6239 email: mkang@unmc.edu name: Soonjo Hwang, MD role: PRINCIPAL_INVESTIGATOR name: Janelle N Beadle, PhD role: SUB_INVESTIGATOR lat: 41.25626 lon: -95.94043 hasResults: False
nctId: NCT06364215 id: 2024P000883 briefTitle: Posterior Wall Substrate Modification Using Irreversible Electroporation for Paroxysmal Atrial Fibrillation acronym: (SMILE-AF) overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2025-12 date: 2024-04-15 date: 2024-04-22 name: Brigham and Women's Hospital class: OTHER name: Boston Scientific Corporation briefSummary: Compare the efficacy and safety between pulmonary vein isolation (PVI) alone versus PVI with left atrial (LA) posterior wall isolation (PWI) using pulsed-field ablation (PFA) in the treatment of patients with paroxysmal atrial fibrillation (PAF). conditions: Atrial Fibrillation Paroxysmal studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 450 type: ESTIMATED name: Pulmonary Vein Isolation alone name: Pulmonary Vein Isolation and Left atrial Posterior Wall Isolation measure: Procedural success, defined as freedom from of all documented atrial arrhythmias episodes after the 3-month blanking period. measure: The primary safety endpoint is a composite of acute procedure-related complications and any other major adverse events within the 12 months following the ablation procedure. measure: Freedom from atrial arrhythmias medication measure: Procedural time measure: Procedure-related Recurrencies measure: Atrial Fibrillation Effect on Quality-of-life Questionnaire (AFEQT). measure: Use of amiodarone measure: Complications. measure: fluoroscopy time. measure: Pulsed field ablation (PFA) applications during procedure. measure: first-pass pulmonary vein isolation (PVI). sex: ALL minimumAge: 21 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Brigham and Women's Hospital city: Boston state: Massachusetts zip: 02115 country: United States name: Obadah Aloum, MD role: CONTACT phone: 617-525-7047 name: Fernando Moreno role: CONTACT phone: 6175257047 name: Jorge E Romero, MD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06364202 id: 1928368 briefTitle: Effects of Peanut Butter on Sleep Quality and Daily Energy Levels in Fire Fighters overallStatus: COMPLETED date: 2022-08-01 date: 2023-11-01 date: 2023-11-01 date: 2024-04-15 date: 2024-04-15 name: Augusta University class: OTHER briefSummary: The purpose of this study is to examine the possible benefits of peanut butter consumption prior to bedtime on sleep and energy levels among fire fighters. Fire fighters require high levels of energy to perform their occupational tasks but commonly lack sleep as well as the amount of dietary protein and fat suggested for tactical athletes. By addressing this gap, we expect that if peanut butter consumption is shown to improve sleep and/or energy, this lifestyle change (peanut butter consumption) may be appealing to fire fighters because of the ease and low cost of peanut butter. Aim 1: Determine if consuming peanut butter prior to bedtime alters measures of sleep quality and quantity in fire fighters. It is hypothesized that firefighters who consume the peanut butter will have positive impacts in measure of sleep quality and energy levels.
Aim 2: Examine the effects of peanut butter consumption on morning and evening energy levels conditions: Sleep conditions: Body Composition conditions: Blood Pressure conditions: Physical Activity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 40 type: ACTUAL name: Peanut Butter measure: Body composition measure: Body composition measure: Sleep measure: Blood pressure measure: Blood pressure measure: Physical activity sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Augusta University city: Augusta state: Georgia zip: 30909 country: United States lat: 33.47097 lon: -81.97484 hasResults: False
nctId: NCT06364189 id: FY22-119 id: R61AG084479 type: NIH link: https://reporter.nih.gov/quickSearch/R61AG084479 briefTitle: Inspiring Seniors Toward Exercise Promotion acronym: iSTEP overallStatus: RECRUITING date: 2024-04-15 date: 2025-04-30 date: 2025-04-30 date: 2024-04-15 date: 2024-04-15 name: University of North Carolina, Greensboro class: OTHER name: National Institute on Aging (NIA) briefSummary: The goal of this clinical trial is to test the benefits of beat-accented music stimulation (BMS) for behavioral changes of physical activity (PA) in older adults. Specific Aims are to determine (1) whether BMS beneficially influences PA behaviors and psychological responses to PA in older adults for 6 months, and (2) whether exercising with BMS differently influences physical and cognitive functioning as well as quality of life in older adults.