hackint0sh/New-Dataset huggingface dataset:
Study objectives The aim of the study is to investigate whether a hemodynamic protocol based on continuous non-invasive cardiac output monitoring (ClearSight system) compared to standard care can reduce the incidence of IOH, postoperative AKI, and MINS in patients undergoing major trauma and orthopedic surgery. conditions: Intraoperative Hypotension conditions: Acute Kidney Injury conditions: Myocardial Injury After Non-cardiac Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Management of interventional group patients Prior to the surgery the rest cardiac index and contractility (dp/dt) must be quantified. For this purpose, the cardiac index will be measured in the preoperative night by applicating the HPI ClearSight system through a study team member. If the rest cardiac index is not available throughout the night because the patient´s sleep is altered by the measurements, the awake cardiac index will be quantified until the monitoring is stopped for the night sleep of the patient. This mean baseline measurements (CI and dp/dt) will then be the target cardiac index throughout the study algorithm (figure 1). In case no sleep measurement was achievable, the awake measurement will be accounted as baseline value. The perioperative study intervention period starts with the beginning of anesthesia and ends at the end of surgery. Intraoperative mean arterial pressure will be maintained at least at 65 mmHg and cardiac index and dp/dt will be individually primaryPurpose: PREVENTION masking: DOUBLE maskingDescription: All patients are connected to the Clearsight device but the interface is masked in the control group. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 150 type: ESTIMATED name: GDT-based hemodynamic management based on Clearsight device measure: Change of the frequency of intraoperative hypotension measure: Change of the absolute duration of of intraoperative hypotension measure: Change of the relative duration of intraoperative hypotension measure: AKI measure: MINS sex: ALL minimumAge: 45 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06291701 id: ODUSBFFTR-ELIFAYGUNPOLAT-002 briefTitle: The Relationship Between Scapular Endurance, Core Endurance, and Functional Performance in Adolescent Tennis Players overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-15 date: 2024-04-01 date: 2024-04-15 date: 2024-03-04 date: 2024-04-04 name: T.C. ORDU ÜNİVERSİTESİ class: OTHER briefSummary: This study aims to examine the relationship between scapular endurance, core endurance, and upper extremity performance in adolescent tennis players. The hypothesis of this study is that better scapular/core endurance in adolescent tennis players is associated with better upper extremity performance. Establishing this relationship will contribute to identifying the exercise training necessary to improve upper extremity performance in tennis players. conditions: Athletic Injuries conditions: Sports Physical Therapy studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 35 type: ESTIMATED name: Assessment of scapular endurance name: Prone Bridge Test name: Side Bridge Test name: Closed Kinetic Chain Upper Extremity Stability Test name: Seated Medicine Ball Throw Test measure: Prone Bridge Test measure: Side Bridge Test measure: Scapular Endurance Values measure: Closed Kinetic Chain Upper Extremity Stability Test measure: Seated Medicine Ball Throw Test sex: ALL minimumAge: 11 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Ordu University city: Ordu zip: 52200 country: Turkey lat: 40.97782 lon: 37.89047 hasResults: False
nctId: NCT06291688 id: 202312004RIND briefTitle: Applying Mobile Healthcare Education to Improve Cutaneous Self-care Capability overallStatus: RECRUITING date: 2024-01-26 date: 2025-12-31 date: 2026-01-31 date: 2024-03-04 date: 2024-03-04 name: National Taiwan University Hospital class: OTHER briefSummary: The goal of this clinical interventional study is to compare the efficacy of mobile healthcare education in two ways (game-based or text-based) to improve cutaneous self-care capability in cancer patients receiving EGFR-based target therapy. The main questions it aims to answer are:
Participants will be randomly divided into two groups. Both groups will download a healthcare education application on their phone. One group will accept the education about the knowledge and self-care skills of cutaneous adverse drug reaction by playing game. In contrast, the other group will accept the same education content by reading text on the phone. Subjects will be asked to use the application at home for two weeks after giving consent to participate this study, and then completed questionnaire three times during study period. The timepoints of completing questionnaire are listed following:
Baseline / pre-intervention test (after signing informed consent form, D1) First post-intervention test (after finishing intervention, D15) Second post-intervention test (D30) Researchers will compare game group and text group to see if game group has better performance on cutaneous self-care capability and learning motivation. conditions: EGFR Gene Mutation conditions: Drug-Related Side Effects and Adverse Reactions conditions: Cancer, Treatment-Related conditions: Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE whoMasked: PARTICIPANT count: 110 type: ESTIMATED name: Mobile healthcare education game name: Mobile healthcare education application measure: Change from baseline in the score of cutaneous adverse drug reaction (CADR) knowledge on researcher-designed questionnaire at Day 15 and Day 30. measure: Investigate the learning motivation towards CADR by self-designed questionnaire at Day 15 measure: Change from baseline in the score of the quality of life on DLQI questionnaire at Day 15 and Day 30 measure: Investigate the user-experience of the mobile healthcare education APP by researcher-designed questionnaire at Day 15. measure: Change from baseline in the score of the self-care measurement adherence on researcher-designed questionnaire at Day 15 and Day30. measure: The correlation among APP usability, learning motivation and self-care capability. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Taiwan University Hospital status: RECRUITING city: Taipei zip: 100225 country: Taiwan name: XinYi Lin, Bs role: CONTACT phone: +886988619601 email: r11426019@ntu.edu.tw lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06291675 id: 2083/2022 briefTitle: Gender-Affirming Hormone Therapy and Its Impact on Myocardial Mass and Cardiac Function, Heart, Liver and Pancreatic Fat Content overallStatus: RECRUITING date: 2023-03-03 date: 2026-03-03 date: 2033-03-03 date: 2024-03-04 date: 2024-03-04 name: Medical University of Vienna class: OTHER briefSummary: Background: Gender affirming hormone therapy (GAHT) leads to profound changes in sex hormone levels, carrying a wide range of implications for major physiological processes in the body. GAHT has been shown to be associated with changes in cardiovascular parameters, the insulin system, body composition, and the psychological state. However, despite the fact that GAHT is usually a long-term intervention, the majority of the research concerns itself with an overall short duration of the therapy and the data on the mid- to long-term effects of GAHT is scarce.
Relevance and implications of the study: The majority of previous research has focused on the short-term effects of gender affirming hormone therapy. Contrastingly, our study aims to focus on the effects of hormone therapy at 2, 5 and 10 years after the beginning of the treatment. Moreover, our study group utilizes measurements of myocardial, hepatic, and pancreatic fat content as well as an MR-assisted measurement of cardiac function, which is a topic that has not been present in research into the effects of gender affirming hormone therapy outside of our pilot study. conditions: Gender Dysphoria conditions: Hormone Therapy Induced Morphologic Change studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: gender-affirming hormone therapy measure: Myocardial mass measure: Cardiac function - LVEF measure: cardiac function - cardiac output index measure: Organ lipid content measure: Subcutaneous to visceral fat ratio sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chiari Stoffwechselambulanz, Medical University of Vienna status: RECRUITING city: Vienna zip: 1090 country: Austria name: Carola Deischinger, MD PhD role: CONTACT phone: +43140400 phoneExt: 20690 email: carola.deischinger@meduniwien.ac.at name: Alexandra Kautzky-Willer, Prof, MD role: CONTACT email: alexandra.kautzky-willer@meduniwien.ac.at name: Alexandra Kautzky-Willer, Prof, MD role: PRINCIPAL_INVESTIGATOR name: Carola Deischinger, MD PhD role: SUB_INVESTIGATOR lat: 48.20849 lon: 16.37208 hasResults: False
nctId: NCT06291662 id: PRECISE_IC briefTitle: Evaluation of Performance Characteristics and Applicability in Oncology of Devices Customized Medical Devices Made by 3D Printing overallStatus: RECRUITING date: 2021-01-01 date: 2024-12-31 date: 2025-06-30 date: 2024-03-04 date: 2024-03-04 name: Kathleen McGreevy class: OTHER briefSummary: Technologies 3D are demonstrating enormous potential for innovation in the field of surgery,introducing the concept of "treatment customization" (from planning surgery to implant design and manufacturing) on the patient's anatomy, simply by taking advantage of the patient's own common diagnostic images and the flexibility of 3D printing. In fact, this new construction technology allows the construction of the complex anatomical geometries with economy, simplicity and on scales of production unattainable by other traditional technologies. This new construction technology allows, in fact, the construction of complex anatomical geometries with economy, simplicity and on scales of production unattainable by other traditional technologies. conditions: Sarcoma conditions: Intracranial Neoplasm conditions: Pelvic Bone Neoplasm studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Oncologic patients primaryPurpose: OTHER masking: NONE count: 12 type: ESTIMATED name: 3D printer applications measure: 3D model feasibility for pre-surgical making decisions measure: Surgical time measure: Device feasibility sex: ALL minimumAge: 7 Years maximumAge: 70 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Azienda Ospedaliero-Universitaria Careggi (AOUC) status: ACTIVE_NOT_RECRUITING city: Firenze country: Italy lat: 43.77925 lon: 11.24626 facility: Meyer Children's Hospital IRCCS status: RECRUITING city: Firenze country: Italy name: Federico Mussa, MD role: CONTACT email: federico.mussa@meyer.it lat: 43.77925 lon: 11.24626 facility: Azienda Ospedaliero Universitaria Senese (AOUS) status: ACTIVE_NOT_RECRUITING city: Siena country: Italy lat: 43.31822 lon: 11.33064 hasResults: False
nctId: NCT06291649 id: AMIETOX briefTitle: Multicentre Prospective Observational Study of Acute Intoxications in Paediatric Age overallStatus: RECRUITING date: 2023-04-05 date: 2033-04-05 date: 2033-08-05 date: 2024-03-04 date: 2024-03-04 name: Meyer Children's Hospital IRCCS class: OTHER briefSummary: Acute intoxications represent a major public health problem, especially when affect a population such as children, who are vulnerable and at greater risk of unintentional and preventable poisonings.
nctId: NCT06291636 id: R.24.01.2451 briefTitle: Re- Admission Rate Among Survived Patients With Acute Respiratory Failure overallStatus: COMPLETED date: 2023-01-01 date: 2023-12-31 date: 2024-01-20 date: 2024-03-04 date: 2024-03-04 name: Mansoura University class: OTHER briefSummary: Readmission to the intensive care unit (ICU) results in increased consumption of medical resources and costs, and has been proposed as a marker for quality of care. ICU readmission rates have been estimated at 4 to 14% and different risk factors have been proposed by various studies Readmitted patients mostly carry poor prognosis compared to newly admitted ones, in addition to the bad psychological impact for both patient and his family conditions: Respiratory Failure studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 994 type: ACTUAL measure: Length of hospital and ICU stay and Cause of readmission sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tamer Awad Elsayed city: Mansoura state: Dakhlia zip: 050 country: Egypt lat: 31.03637 lon: 31.38069 hasResults: False
nctId: NCT06291623 id: Molecular Analysis briefTitle: Molecular Analysis of Intracanal Microbes After Chemomechanical Procedure and Root Canal Medication: Clinical Study overallStatus: COMPLETED date: 2022-05-03 date: 2023-12-20 date: 2024-01-15 date: 2024-03-04 date: 2024-03-04 name: Mansoura University class: OTHER briefSummary: This study aimed to evaluate clinically the intracanal microbes at molecular level after using established root canal medicament Calcium hydroxide and potential root canal medicament Glycyrrhizin.and Decontamination Analysis of Controls samples. conditions: Bacterial Viability of Necrotic Pulp With Asymptomatic Apical Periodontitis studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 20 type: ACTUAL name: Glycyrrhizin measure: minimizing of viable bacteria which showed by Real time PCR sex: ALL minimumAge: 19 Years maximumAge: 60 Years stdAges: ADULT facility: Mansoura University city: Mansoura state: Dakahliya zip: 35511 country: Egypt lat: 31.03637 lon: 31.38069 hasResults: False
nctId: NCT06291610 id: Aarhus University Hospital briefTitle: Feasibility Testing a Decision-support Intervention for Clinical Trials overallStatus: RECRUITING date: 2024-02-19 date: 2025-12-31 date: 2026-12-31 date: 2024-03-04 date: 2024-03-04 name: University of Aarhus class: OTHER briefSummary: A decision-support intervention are developed for a Danish nationwide randomised controlled trial (RCT) among patients with laryngeal and pharyngeal cancer referred to curative intended radiotherapy. The primary endpoints in this RCT are levels of dysphagia and xerostomia.
A total of 12 physicians will be recruited and trained in decision coaching. To assess the acceptability of the intervention, the physicians will be interviewed. Additionally, they will be asked to audio-record two decision coaching sessions to test the fidelity of the intervention. conditions: Head and Neck Neoplasms studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Pre- and post-intervention measures in two consecutive groups. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE maskingDescription: Patients are recruited anonymous count: 60 type: ESTIMATED name: Clinical trial decision support intervention measure: Decisional conflict scale measure: The decision preparation scale measure: The stages of decision making measure measure: Items on health literacy sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Aarhus University Hospital status: RECRUITING city: Aarhus zip: 8200 country: Denmark name: Anne Kristensen role: CONTACT phone: +4530315605 email: annkrs@rm.dk name: Cai Grau role: CONTACT email: cai.grau@rm.dk lat: 56.15674 lon: 10.21076 hasResults: False
nctId: NCT06291597 id: 22071 briefTitle: Vaping Adverse Lung and Heart Events Cohort acronym: VapALERT overallStatus: RECRUITING date: 2021-10-14 date: 2031-12 date: 2032-06 date: 2024-03-04 date: 2024-03-04 name: Laval University class: OTHER name: Ministere de la Sante et des Services Sociaux briefSummary: This prospective study assesses the pulmonary and cardiovascular effets of vaping in adult electronic cigarette users with biannual visits and a 5-year follow-up. conditions: Vaping conditions: Electronic Cigarette Use studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 250 type: ESTIMATED name: Vaping measure: Number of participants who vape daily with impaired lung volumes. measure: Number of participants who vape daily with impaired lung diffusion capacity. measure: Number of participants who vape daily with impaired spirometry. measure: Number of participants who vape daily with airway hyperresponsiveness. measure: Number of participants who vape daily with changes in blood cell count. measure: Number of participants who vape daily with changes in sputum cell count. measure: Vaping, tobacco and cannabis smoking habits of participants. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IUCPQ-UL status: RECRUITING city: Québec zip: G1V 4G5 country: Canada name: Ariane Lechasseur, PhD role: CONTACT phone: 418-656-8711 phoneExt: 2652 email: ariane.lechasseur@criucpq.ulaval.ca name: Mathieu C Morissette, PhD role: PRINCIPAL_INVESTIGATOR name: Andréanne Côté, MD, MSc role: PRINCIPAL_INVESTIGATOR lat: 46.81228 lon: -71.21454 hasResults: False
nctId: NCT06291584 id: P20230001 briefTitle: Effects of Exercises on Functional Capacity overallStatus: RECRUITING date: 2023-10-01 date: 2024-05-01 date: 2024-10-01 date: 2024-03-04 date: 2024-03-08 name: Kırklareli University class: OTHER briefSummary: In this study, the researchers aim to investigate the effects of strengthening and respiratory exercises on the face and online on functional capacity. conditions: Nicotine Addiction conditions: Respiratory Disease conditions: Sedentary Behavior studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study consists of three groups. Groups to be formed: Group 1: face-to-face exercise group; Group 2: Online (Telehealth) Exercise Group; Group 3: Control Group primaryPurpose: TREATMENT masking: SINGLE maskingDescription: First of all, the randomization of exercise groups will be performed according to the closed envelope procedure. The student who selects one of the envelopes with the names of the three groups will be included in the group written in the envelope he selected. whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: Exercise measure: International Physical Activity Questionnaire - Short Form measure: Six-Minute Walk Test- (6MWT) sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Kirklareli University status: RECRUITING city: Kırklareli state: Kayalı zip: 39000 country: Turkey name: Fulya DEMIRHAN, Res. Ass. role: CONTACT phone: +90-532-353-2208 email: fulyademirhan@klu.edu.tr lat: 41.73508 lon: 27.22521 hasResults: False
nctId: NCT06291571 id: 324543 briefTitle: Assessment of Microorganisms and Host Response In Liver Diseases acronym: MILD overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2029-02-28 date: 2030-03-01 date: 2024-03-04 date: 2024-03-04 name: University of Aberdeen class: OTHER briefSummary: The normal human gut is home to millions of microbes including bacteria, fungi, and viruses, collectively forming the gut microbiota, which exists in harmony within us. Much research is still required to fully understand the contribution of microbes resident in the large intestine in liver diseases. The liver receives blood from the gut carrying all the necessary nutrients needed for our body but also has to deal with toxins derived from the microbes residing in the intestines. The gut microbiota is altered in liver disease. We still do not know clearly how this change impacts liver function and the health of liver patients. The purpose of our study is to answer this question by assessing the gut microbiota using modern microbiological and molecular methods. By studying the alterations in the gut microbiota in patients with liver disease we can understand how they affect our immune system and metabolism. This will help design novel medicinal products to prevent and treat liver disease. conditions: Gut Microbiome conditions: Liver Diseases studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: To identify the bacterial, fungal, and virological agents present in patients with liver disease as opposed to controls measure: To assess the host immune response against specific microbes isolated from patients with liver disease and controls measure: To characterise the changes in the liver immune microenvironment by analysing liver biopsies from patients sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06291558 id: P202200027 briefTitle: Exercise Training for Smoking Students overallStatus: RECRUITING date: 2023-10-01 date: 2024-05-01 date: 2024-10-01 date: 2024-03-04 date: 2024-03-04 name: Kırklareli University class: OTHER briefSummary: Smoking can damage lung functions as a result of high carbon monoxide and low hemoglobin oxygen carrying capacity in the blood. Smoking between young people continues to increase, which can cause respiratory function problems and lung diseases at an early age. In the studies, it has been seen that smoking may reduce the oppression and exercise ability. conditions: Nicotine Dependence conditions: Smoking conditions: Physical Inactivity conditions: Depression studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE maskingDescription: The participants will be informed that the study was carried out for scientific purposes and the information will not be shared with third parties. Randomization of exercise groups will be performed according to the closed envelope procedure. The student who selects one of the envelopes with the names of the 3 groups will be included in the group written in the envelope he selected. Information about other groups will not be shared. whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: Exercise measure: International Physical Activity Questionnaire (Short) measure: Six-Minute Walk Test measure: Scoring the Fagerstrom Test for Nicotine Dependence (FTND) measure: Beck's Depression Inventory (BDI) measure: Lung Function Test sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Kirklareli University status: RECRUITING city: Kırklareli state: Kayalı zip: 39000 country: Turkey name: Fulya DEMIRHAN, Res. Ass. role: CONTACT phone: +90-532-353-2208 email: fulyademirhan@klu.edu.tr lat: 41.73508 lon: 27.22521 hasResults: False
nctId: NCT06291545 id: JW-SBC202202 briefTitle: Effectiveness and Safety of Coronary Scoring Balloon Dilation Catheter in the Pretreatment of Coronary Stenosis Lesions overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2024-12-31 date: 2025-06-30 date: 2024-03-04 date: 2024-03-05 name: JW Medical Systems Ltd class: INDUSTRY briefSummary: This trial adopts a prospective, multicenter, randomized controlled, and non-inferiority comparison trial design, and plans to recruit 200 eligible subjects who will be randomly assigned to the experimental group or the control group in a 1:1 ratio. All randomly enrolled subjects will be followed up until 30 days after the surgery. conditions: Coronary Artery Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 200 type: ESTIMATED name: Coronary artery scoring balloon dilation catheter（JW Medical Systems Ltd） name: ScoreFlex NC Coronary Dilatation Catheter measure: Rate of successful device usage measure: Rate of success of the surgery measure: Incidence of in-hospital MACE measure: Incidence of PoCE within 30 days after surgery measure: The lumen is obtained immediately sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False