hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06377657 id: DONT4GET briefTitle: Oxidative and Antioxidant Indices to HIIT and Aloe Vera Supplementation in Patients With T2DM overallStatus: COMPLETED date: 2022-01-15 date: 2023-06-21 date: 2024-02-19 date: 2024-04-22 date: 2024-04-22 name: University of Nis class: OTHER briefSummary: Diabetes is a prevalent metabolic disease that leads to increased blood sugar levels due to insulin shortage or resistance. Type 2 diabetes is often linked to obesity, which can increase insulin resistance. Meteorin-like protein (METRNL) is a new secreted protein that affects insulin sensitivity and has been found to be negatively related to serum glucose levels in people with diabetes.
The present study aims to investigate the response of METRNL and some oxidative and antioxidant plasma indicators to high-intensity interval training and Aloe vera supplementation in type 2 diabetic men. The findings indicate that exercise and consumption of plants with anti-inflammatory and antioxidant properties can be effective in modulating the pathological effects of diabetes and increasing insulin sensitivity. conditions: Diabetes Type 2 studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: The participants were blinded for the supplementation. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 44 type: ACTUAL name: Exercise name: Aloe vera measure: METRNL - Meteorin Like, Glial Cell Differentiation Regulator measure: Glutathione peroxidase (GPx) measure: Serum superoxide dismutase (SOD) measure: Total antioxidant blood capacity (TAD) measure: Plasma malondialdehyde (MDA) sex: MALE minimumAge: 25 Years maximumAge: 40 Years stdAges: ADULT facility: Department of Sport Physiology, Faculty of Sport and Physical education, Islamic Azad University of Ayatollah Amoli, Amol, Iran city: Amol country: Iran, Islamic Republic of lat: 36.46961 lon: 52.35072 hasResults: False
nctId: NCT06377644 id: DPT/Batch-Fall19/560 briefTitle: Comparing the Efficacy of KT vs DN With Conventional Treatment for Improving QOL and Alleviating Pain in Frozen Shoulder overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-01 date: 2024-05-01 date: 2024-07-05 date: 2024-04-22 date: 2024-04-22 name: Superior University class: OTHER briefSummary: "Randomized control trial is our study design, we will make 2 groups group A ( 15 patients of frozen shoulder) and Group B (15 patients of frozen shoulder). we will apply interventions by this way For group A KT (kinesiology taping) will be applied on frozen shoulder patients by a professional physiotherapist or certified physiotherapist according to their pain pattern in muscles (supraspinatus, infraspinatus, teres minor, deltoid, subscapularis) with conventional physiotherapy of frozen shoulder also continues on 15 patients (group A). KT will apply twice a week for 8 weeks. We can check the results of our intervention every week by using variable tools or outcome measures, measuring pain by VAD (visual analog scale) and quality of life in the frozen shoulder by SPADI (shoulder pain and disability index) every week. And for group B Dry needling with conventional physical therapy. conditions: Frozen Shoulder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 30 type: ACTUAL name: Kinesio taping name: Dry Needling measure: VAS measure: SPADI sex: ALL minimumAge: 35 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pain away Physical Therapy city: Lahore state: Punjab country: Pakistan lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06377618 id: DPT/Batch-Fall19/556 briefTitle: Comparison Of Resistance Training And Core Strengthening Exercises Vitamin D In Postmenopausal Women With Low Back Pain overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-15 date: 2024-05-20 date: 2024-06-20 date: 2024-04-22 date: 2024-04-22 name: Superior University class: OTHER briefSummary: This study aims to evaluate the effectiveness of resistance training, core strengthening exercises, and vitamin D supplementation in reducing low back pain (LBP) among postmenopausal women. conditions: Menopausal conditions: Pain, Low Back studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 36 type: ACTUAL name: Resistance Training and Core Strengthening Exercises Group name: Resistance Training and Core Strengthening Exercises Group Plus Vitamin D Supplementation measure: Visual Analog Scale (VAS) measure: Oswestry Disability Index (ODI) sex: FEMALE minimumAge: 50 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Azra Naheed Medical College, Superior University city: Lahore state: Punjab country: Pakistan lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06377605 id: MD-15-2024 briefTitle: The Efficacy of Thoracic Erector Spinae Plane Block For Perioperative Analgesia in Laparoscopic Bariatric Surgery for Super Obese Patients: Randomized Controlled Trial. overallStatus: RECRUITING date: 2023-03-10 date: 2024-06-30 date: 2024-08-30 date: 2024-04-22 date: 2024-04-22 name: Amany Ahmed Eissa class: OTHER briefSummary: The epidemic of overweight and obesity presents a major challenge to chronic disease prevention and health across the life course around the world. \[1\] Bariatric surgery has proved to be an efficient intervention in the management of obesity. As a result, the number of post-bariatric surgery patients in the population is growing \[2\].
Peripheral nerve blocks in the obese may pose challenges, like difficulties in proper patient positioning and landmark identification. However, Ultrasound guidance may help overcome many difficulties in regional techniques. But as expected, targets are more deeply situated in obese patients and the ultrasound beams are attenuated as they travel a greater distance through tissue layers. Additionally, when crossing a tissue boundary, a portion is reflected back to the transducer creating artifacts like speckling and clutter which are particular problems in the obese patient. \[15\] Few studies examined the use of ESPB in bariatric surgery \[3,6,7\], all indicating potential benefits of the technique in terms of opioid sparing and pain control. To date, the efficacy of ESPB has not been examined in superobese patient.
So we aim to compare the perioperative analgesic effect of bilateral ultrasound-guided ESPB with controls, Local bupivacaine infiltration to the trocar sites, in super obese patients undergoing bariatric surgery We hypothesis that ESBP provides good applicable modality of perioperative analgesia for superobese patients undergoing bariatric surgeries. conditions: Erector Spinae Plane Block conditions: Super Obese Patients conditions: Bariatric Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: randomized controlled trial- single blinded primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Computer-generated sequence will be used for randomization and opaque envelopes will be used for concealment. whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: ESPB name: local anaesthetic infiltration name: midazolam and lidocaine name: Bupivacain measure: Total opioid consumption measure: VAS score during first 24 hour postoperative sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Kasr Al Ainy Hospitals status: RECRUITING city: Cairo country: Egypt name: amany ahmea eissa, lecturer role: CONTACT phone: 01001807207 email: amany.eissa@kasralainy.edu.eg name: marwa saeed zayed, ass. professor role: CONTACT phone: 01003347560 email: marwa.zayed@kasralainy.edu.eg lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06377592 id: G22396 briefTitle: Development and Accuracy Evaluation of Gram Staining Analysis AI overallStatus: RECRUITING date: 2023-05-10 date: 2027-03-31 date: 2027-03-31 date: 2024-04-22 date: 2024-04-22 name: GramEye class: INDUSTRY briefSummary: The investigators use Gram-stained specimens provided from clinical settings to develop and evaluate the accuracy of Gram staining analysis AI conditions: Bacterial Infections studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 18000 type: ESTIMATED name: Sample collection without intervention measure: Advanced level of blood culture Gram stain analysis AI accuracy measure: Ordinary level of blood culture Gram stain analysis AI accuracy sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Osaka University Hospital status: RECRUITING city: Suita state: Osaka zip: 5650871 country: Japan name: Go Yamamoto role: CONTACT lat: 34.76143 lon: 135.51567 hasResults: False
nctId: NCT06377579 id: FILObsLAM_IVOOBS briefTitle: OBServatory of Compassionate Use of IVOsidenib in France for Patients With Acute Myeloid Leukemia overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2024-12-15 date: 2025-03-15 date: 2024-04-22 date: 2024-04-22 name: French Innovative Leukemia Organisation class: OTHER name: Acute Leukemia French Association briefSummary: Mutations in IDH genes are found in numerous cancers and more specifically in acute myeloid leukemia (AML). These mutations target specific amino acids, at positions 140 or 172 of IDH2, and 132 of IDH1. Mutant IDH proteins acquire an abnormal enzymatic activity allowing them to convert α-ketoglutarate (αKG) into D-2 hydroxyglutarate (D-2HG), an oncometabolite which massively accumulates in IDH-mutated cells. At high levels, D-2HG behaves as a competitive inhibitor of αKG and affects the activity of Fe(II)/αKG-dependent dioxygenases. This enzymatic family is involved in a broad spectrum of pathways such as demethylation of histone (JHDM histone demethylases) or DNA (methylcytosine hydroxylases of the TET family). As a result, IDH-mutated cells show altered survival, motility, invasiveness and cell differentiation. In AML, IDH1 mutations might be present in 10-15% at diagnosis
Ivosidenib (IVO) a first-in-class, oral, irreversible inhibitor of mutant IDH1 has shown clinical activity as a single agent in studies involving patients with IDH1 mutated relapsed or refractory (R/R) AML (DiNardo et al. 2018) and in front line settings (Montesinos et al. 2022). In phase II clinical trials, IVO yielded 30-35% of complete response rates both in frontline and R/R settings, with long lasting responses. Based on these results, the FDA (Food and Drug Agency) gave its approval for newly-diagnosed AML IDH1mut patients who are ≥ 75 years old or who have comorbidities and in R/R. However, European Medicines Agency (EMA)'s did not approved IVO due to lack of evidences to support the application. Agios Netherlands B.V. (the company that previously own the drug before Servier Laboratories) withdrew its EMA application. Nevertheless, IVO has been available in France through a compassionate use program (CUP), since February 2020 for R/R patients and March 2022 for first line treatment.
In this multicentric retrospective study, we aim to evaluate the efficacy and safety of Ivo in two cohorts of IDH1mut AML patients treated within the CUP. The first cohort will concern patients treated in first line setting and the second cohort those treated in R/R disease. Our results might provide new insights regarding IVO in real life settings and support signs of efficacy. This could provide new data for the haematologist community and for another appliance to grant EMA approval of IVO in the setting of R/R IDH1mut AML. conditions: AML, Adult studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 250 type: ESTIMATED measure: characterize the Overall survival (OS) in the both cohort : 1st line and Relapsed/Refractory (R/R) measure: characterize the composite response rate (CRc) at any time during follow-up, for the both cohort : 1st line and Relapsed/Refractory (R/R) measure: characterize the Event Free Survival (EFS) in both cohorts : 1st line and Relapsed/Refractory (R/R) measure: characterize the incidence and relatedness of serious adverse events (SAE), for patients treated by Ivosidenib, for both cohorts : 1st line and Relapsed/Refractory (R/R) measure: describe the management of treatment by Ivosidenib in both cohorts : 1st line and Relapsed/Refractory (R/R) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Amiens CHU city: Amiens country: France lat: 49.9 lon: 2.3 facility: Angers CHU city: Angers country: France lat: 47.46667 lon: -0.55 facility: Bayonne CH city: Bayonne country: France lat: 43.48333 lon: -1.48333 facility: Besançon CHU city: Besançon country: France lat: 47.24878 lon: 6.01815 facility: CHU Estaing city: Clermont-Ferrand country: France lat: 45.77966 lon: 3.08628 facility: Créteil CHU HENRI MONDOR city: Créteil country: France lat: 48.78333 lon: 2.46667 facility: Grenoble CHU city: Grenoble country: France lat: 45.16667 lon: 5.71667 facility: Le Mans CH city: Le Mans country: France lat: 48.0 lon: 0.2 facility: Lyon sud CHU city: Lyon country: France lat: 45.74848 lon: 4.84669 facility: Marseille IPC city: Marseille country: France lat: 43.29551 lon: 5.38958 facility: Meaux CH de l'Est francilien city: Meaux country: France lat: 48.96014 lon: 2.87885 facility: Montpellier - Chu Saint Eloi city: Montpellier country: France lat: 43.61092 lon: 3.87723 facility: Nantes CHU city: Nantes country: France lat: 47.21725 lon: -1.55336 facility: Nice CHU city: Nice country: France lat: 43.70313 lon: 7.26608 facility: Orléans CHU city: Orléans zip: 45000 country: France lat: 47.90289 lon: 1.90389 facility: Paris Saint Louis city: Paris country: France lat: 48.85341 lon: 2.3488 facility: Bordeaux CHU city: Pessac country: France lat: 44.81011 lon: -0.64129 facility: ICANS - Institut de cancérologie de strasbourg europe city: Strasbourg country: France lat: 48.58392 lon: 7.74553 facility: Toulouse - IUCT Oncopole - Service d'Hématologie city: Toulouse country: France lat: 43.60426 lon: 1.44367 hasResults: False
nctId: NCT06377566 id: 24-039 briefTitle: A Study of BV-AVD in People With Bulky Hodgkin Lymphoma overallStatus: RECRUITING date: 2024-04-17 date: 2027-04 date: 2027-04 date: 2024-04-22 date: 2024-04-22 name: Memorial Sloan Kettering Cancer Center class: OTHER name: Seagen Inc. briefSummary: The purpose of this study is to test whether BV-AVD is an effective treatment in people with early stage, bulky Hodgkin lymphoma that was recently diagnosed and who have not yet received any treatments for their disease.
nctId: NCT06377553 id: 2023P000955 briefTitle: PET/MRI for Evaluation of Endometriosis overallStatus: NOT_YET_RECRUITING date: 2024-05-03 date: 2026-05-03 date: 2026-05-03 date: 2024-04-22 date: 2024-04-22 name: Massachusetts General Hospital class: OTHER briefSummary: This study aims to determine if PET/MRI can detect endometriosis and potentially improve upon currently available non-invasive diagnostic capabilities. Specifically, the authors will investigate the ability of PET/MRI to detect and quantify endometriosis, as well as differentiate among subcategories such as inflammatory peritoneal lesions, fibrotic deep infiltrating endometriosis lesions (DIE), and ovarian endometriomas. The authors will compare \[68Ga\]CBP8 or \[18F\]-FAPI-74 PET/MRI imaging versus the current gold standard diagnostic methods, including laparoscopic surgery, clinical follow-up, and follow-up imaging. conditions: Endometriosis conditions: Endometrioma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: Radiotracer Injection name: Imaging name: Rectal Ultrasound Gel Injection measure: Diagnostic Accuracy of PET/MR in Preoperative Endometriosis Detection measure: Diagnostic Performance of PET/MRI vs. Conventional Imaging measure: Impact of [18F]-FAPI-74 and [68Ga]CBP8 PET/MRI on Diagnosis and Management in Endometriosis measure: Correlation of Pre-Treatment PET Uptake and Post-Treatment Response in Endometriosis sex: FEMALE minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School city: Charlestown state: Massachusetts zip: 02129 country: United States name: Onforio Catalano, MD, Ph.D role: CONTACT phone: 617-724-4030 email: ocatalano@mgh.harvard.edu name: Diandrea Galloway role: CONTACT phone: 617-643-1407 email: dgalloway@mgh.harvard.edu lat: 42.37787 lon: -71.062 hasResults: False
nctId: NCT06377540 id: 2022LS174 briefTitle: MT2022-60: Ph 2 Study of Pembro+ BEAM With ASCT for Relapsed Hodgkin Lymphoma overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2026-09-01 date: 2027-09-01 date: 2024-04-22 date: 2024-04-22 name: Masonic Cancer Center, University of Minnesota class: OTHER briefSummary: This is a Phase 2 single arm study to evaluate efficacy and safety of Pembrolizumab before with BEAM ASCT followed by Pembrolizumab maintenance for 1 year. Patients will receive 200 mg Pembrolizumab Q3week starting at day - 28 before stem cell transplant until 1 year after autologous stem cell transplant. conditions: Autologous Stem Cell Transplant conditions: Classic Hodgkin Lymphoma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 28 type: ESTIMATED name: Pembrolizumab name: Autologous stem cell transplant name: Carmustine name: Etoposide name: Cytarabine name: Melphalan measure: Progression free survival (PFS) measure: Overall survival (OS) measure: Progression-free survival (PFS) measure: Non-relapse mortality (NRM) measure: Overall Survival (OS) measure: Rate of Complete Metabolic Response sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06377527 id: 2023-0945 id: NCI-2024-03342 type: OTHER domain: NCI-CTRP Clinical Registry briefTitle: Establishing a Tumor Registry of Patients With Mesonephric-like Adenocarcinoma (MLA) overallStatus: NOT_YET_RECRUITING date: 2024-10-31 date: 2035-12-28 date: 2037-12-28 date: 2024-04-22 date: 2024-04-22 name: M.D. Anderson Cancer Center class: OTHER briefSummary: To develop a database of medical information about patients with MLA in an effort to increase our understanding of the characteristics of MLA, which is the rarest form of endometrial carcinoma. conditions: Mesonephric-like Adenocarcinoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 2000 type: ESTIMATED measure: Tumor Registry sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: MD Anderson Cancer Center city: Houston state: Texas zip: 77030 country: United States name: Jeffrey How, MD role: CONTACT name: Jeffrey How, MD role: PRINCIPAL_INVESTIGATOR lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06377514 id: PCOL109PHNG briefTitle: Clinical Investigation of the TECNIS® Next-Generation Intraocular Lens overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-10-31 date: 2025-10-31 date: 2024-04-22 date: 2024-04-22 name: Johnson & Johnson Surgical Vision, Inc. class: INDUSTRY briefSummary: Prospective, multicenter, bilateral, interventional, controlled, masked (sponsor, subjects, and evaluators), randomized clinical trial. conditions: Cataracts studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 250 type: ESTIMATED name: Test IOL Model DEN00V name: Control IOL Model DCB00 measure: Monocular photopic DCIVA (first eyes) at 66 cm measure: Monocular Depth of Focus measure: Monocular Photopic BCDVA at 4m measure: Monocular Photopic DCVA at 100 cm measure: Monocular photopic DCNVA at 40 cm (first eyes) sex: ALL minimumAge: 22 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06377501 id: 804687 briefTitle: Feasibility of a Whole-Food, Plant-Based Diet for Patients With Low-Risk Chronic Lymphocytic Leukemia (CLL) overallStatus: RECRUITING date: 2023-03-07 date: 2024-07-01 date: 2024-07 date: 2024-04-22 date: 2024-04-22 name: University of California, San Diego class: OTHER briefSummary: This study will evaluate the feasibility of an 8-week vegan whole-food, plant-based dietary intervention in subjects with low risk CLL who are undergoing observation. Over the course of 8 weeks, participants will attend weekly group cooking classes via Zoom lead by a RD. Participants will also attend weekly individual meetings with a health coaches to assist with adherence to the dietary intervention. conditions: Chronic Lymphocytic Leukemia Stage A(0) studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 18 type: ESTIMATED name: Whole-food, plant-based diet measure: Adherence to the Dietary Intervention measure: Satisfaction with the Dietary Intervention measure: Cooking Class Adherence measure: Recruitment measure: Retention measure: White blood cell count measure: Absolute lymphocyte count measure: Anthropometric Measures (height, weight, body mass index) measure: Anthropometric Measures (waist circumference) measure: Biomarkers of cardiometabolic health (complete metabolic panel) measure: Biomarkers of cardiometabolic health (hemoglobin A1c) measure: Biomarkers of cardiometabolic health (cholesterol and triglycerides) measure: Concentration of vitamin B12 measure: Concentration of vitamin B9 measure: Concentration of iron measure: Concentration of ferritin measure: Blood pressure sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UC San Diego status: RECRUITING city: San Diego state: California zip: 92093 country: United States name: Ariel Portera, DO role: CONTACT phone: 858-249-6896 email: aportera@health.ucsd.edu lat: 32.71533 lon: -117.15726 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-02-23 uploadDate: 2024-04-17T18:09 filename: ICF_000.pdf size: 514422 hasResults: False
nctId: NCT06377475 id: 2024-00148 id: 2024-00148 type: REGISTRY domain: EKNZ briefTitle: Fabrication and Insertion of Michigan Splints by Dental Students overallStatus: ENROLLING_BY_INVITATION date: 2024-03-08 date: 2024-05 date: 2025-12 date: 2024-04-22 date: 2024-04-22 name: Juliana Marotti Großhausen class: OTHER briefSummary: The aim of this study is to investigate the potential effects of different jaw relation determination (KRB) techniques on the fabrication of Michigan splints, in particular by comparing conventional methods with a wax plate and the use of an anterior jig. All materials and methods for the fabrication of the Michigan splint are already part of the curriculum of the Clinic for Dental Prosthodontics for first-year Master-students. Therefore, we intend to conduct a retrospective study (for the 2023 cohort) and a prospective analysis of the data (for the 2024 and 2025 cohorts). Questionnaires, models and intraoral scans will be used to evaluate the efficacy and precision of the different KRB methods as well as the fabrication process of the Michigan splint. conditions: Impression Technic, Dental conditions: Jaw Relationship conditions: Bruxism studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 73 type: ESTIMATED name: Jaw relation name: Questionnaire measure: Wax vs JIG Registration measure: Questionnaire sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UZB city: Basel zip: 4058 country: Switzerland lat: 47.55839 lon: 7.57327 hasResults: False