hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06389552 id: IN_CTP_N01 briefTitle: Long-term Observational Study to Evaluate the DFS and OS of Adjuvant FOLFIRINOX Regimen in Pancreatic Cancer Patients overallStatus: RECRUITING date: 2023-09-25 date: 2026-12 date: 2027-12 date: 2024-04-29 date: 2024-04-29 name: HK inno.N Corporation class: INDUSTRY briefSummary: This study is designed to evaluate the safety and efficacy of adjuvant FOLFIRINOX regimen in pancreatic cancer patients after curative surgery. conditions: Adjuvant Chemotherapy studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 36 type: ESTIMATED measure: Disease-free survival measure: Overall survival sex: ALL minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Seoul ST. Mary's Hospital status: RECRUITING city: Seoul country: Korea, Republic of name: Myung-Ah Lee role: CONTACT name: Myung-Ah Lee role: PRINCIPAL_INVESTIGATOR lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06389539 id: Pro00070958 briefTitle: Synbiotic to Attenuate Resorption of the Skeleton acronym: STARS overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2028-04 date: 2028-04 date: 2024-04-29 date: 2024-04-29 name: Hebrew SeniorLife class: OTHER name: Solarea Bio, Inc name: Beth Israel Deaconess Medical Center name: Tufts University name: MaineHealth briefSummary: This randomized, double blind, placebo controlled clinical trial will test the efficacy of a probiotic/prebiotic combination ("synbiotic") on the skeleton in older women. conditions: Osteoporosis conditions: Inflammation conditions: Aging studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants will be randomized to either SBD111 medical food or placebo capsules for a period of 18 months. primaryPurpose: OTHER masking: QUADRUPLE maskingDescription: Study staff involved in participants' outcome assessments will be masked to the intervention assignment. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 220 type: ESTIMATED name: SBD111 medical food name: Placebo measure: Lumbar spine BMD (g/cm2) measure: Vertebral compressive strength (N) measure: volumetric BMD measure: C-terminal cross-linked telopeptide of type I collagen (β-CTX) measure: Procollagen Type I Intact N-terminal Propeptide (P1NP) sex: FEMALE minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hebrew SeniorLife city: Roslindale state: Massachusetts zip: 02131 country: United States name: Kathryn Tasker role: CONTACT phone: 617-971-5351 email: KathyTasker@hsl.harvard.edu lat: 42.29121 lon: -71.1245 hasResults: False
nctId: NCT06389526 id: CHS-1000-01 briefTitle: A Study of CHS-1000 in Participants With Advanced or Metastatic Solid Tumors overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2028-01-30 date: 2028-01-30 date: 2024-04-29 date: 2024-04-29 name: Coherus Biosciences, Inc. class: INDUSTRY briefSummary: The primary purpose of this trial is to assess the tolerability and safety of CHS-1000 alone and in combination with toripalimab-tpzi in participants with advanced solid tumors. conditions: Advanced or Metastatic Solid Tumors studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 48 type: ESTIMATED name: CHS-1000 name: Toripalimab measure: Number of Participants with Treatment-Emergent Adverse Events (TEAEs) measure: Maximum Observed Concentration (Cmax) measure: Area Under the Concentration-time Curve (AUC) measure: Terminal Half-life (t1/2) measure: Number of Participants with Antidrug Antibodies measure: Investigator-assessed Objective Response Rate (ORR) measure: Duration of Response (DoR) measure: Disease Control Rate (DCR) measure: Time to Response (TTP) measure: Progression-free Survival (PFS) measure: Landmark PFS Rate sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06389513 id: CTP-MCVF-005 briefTitle: Clinical Study of the Safety of Menhycia® in 3-Month-Old Infants overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-04 date: 2025-04 date: 2024-04-29 date: 2024-04-29 name: CanSino Biologics Inc. class: INDUSTRY briefSummary: This study is an open, multicenter Phase IV clinical study to evaluate the safety of vaccination with Menhycia®. The study plan is to enroll approximately 3,000 infants at 3 months of age who have not been vaccinated with any epidemic encephalitis vaccine, and to administer a total of 3 doses of Menhycia®, with a minimum of 1 month between doses, and a booster dose of 1 dose of immunization is allowed at 12 months of age. conditions: Epidemic Meningitis studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 3000 type: ESTIMATED name: MCV4 measure: Incidence of localized adverse reactions in subjects measure: Incidence of systemic adverse reactions in subjects measure: Incidence of adverse reactions in subjects measure: Incidence of adverse events in subjects measure: Incidence of severe adverse events sex: ALL minimumAge: 3 Months maximumAge: 3 Months stdAges: CHILD hasResults: False
nctId: NCT06389500 id: SHR-1316-HLJ-006 briefTitle: HAIC+Adebrelimab+Lenvatinib for Conversion Treatment of Potentially Resectable, Locally Advanced Biliary Tract Cancer overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-05-01 date: 2028-05-01 date: 2024-04-29 date: 2024-04-29 name: Harbin Medical University class: OTHER briefSummary: This is a single-arm, exploratory, phase II trial to evaluate the efficacy and safety of hepatic arterial infusion chemotherapy combined with adebrelimab and lenvatinib for borderline resectable, locally advanced biliary tract cancer. conditions: Biliary Tract Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Adebrelimab name: Lenvatinib name: Hepatic Arterial Infusion Chemotherapy measure: R0 resection rate measure: Surgery conversion rate measure: Objective response rate measure: pathological complete response rate measure: Major pathological response rate measure: Recurrence-free survival measure: Overall survival measure: AEs sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06389461 id: OST1_012 briefTitle: 4th Ventricular Compression Technique on Anxiety overallStatus: NOT_YET_RECRUITING date: 2024-09-16 date: 2024-12-31 date: 2024-12-31 date: 2024-04-29 date: 2024-04-29 name: Escola Superior de Tecnologia da Saúde do Porto class: OTHER briefSummary: Determinate the effects of the technique of 4th ventricle in college students with anxiety, applying the technique one time per week during three weeks. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE whoMasked: PARTICIPANT count: 30 type: ESTIMATED name: 4th Ventricular Compression Technique name: "Sham" Therapy measure: Change from baseline in anxiety levels through the STAI (The State-Trait Anxiety Inventory) questionnaire score on the 1st and last intervention. measure: Change from baseline in thoraco-abdominal perimetry on the 1st and last intervention sex: ALL minimumAge: 18 Years maximumAge: 25 Years stdAges: ADULT facility: Escola Superior da Saúde do Porto city: Porto zip: 4200-072 country: Portugal lat: 41.14961 lon: -8.61099 hasResults: False
nctId: NCT06389448 id: pCLE vs EB 2024tj briefTitle: Comparison of pCLE and EB in Gastric Lesion Diagnosis overallStatus: RECRUITING date: 2024-04-11 date: 2026-04 date: 2026-10 date: 2024-04-29 date: 2024-04-29 name: Huazhong University of Science and Technology class: OTHER briefSummary: This is a prospective multicenter comparative study, aiming to compare probe-based confocal laser endomicroscopy (pCLE) and endoscopic biopsies in the diagnosis of the whole specific gastric lesion especially for distinguishing low grade intraepithelial neoplasia (LGIN) from high grade intraepithelial neoplasia (HGIN) and create an endoscopic image database for the follow-up research. conditions: Low Grade Intraepithelial Neoplasia conditions: High Grade Intraepithelial Neoplasia conditions: Early Gastric Cancer conditions: Gastric Intraepithelial Neoplasia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Participants undergo pCLE after pre-ESD assessment and before ESD resection. primaryPurpose: DIAGNOSTIC masking: NONE count: 366 type: ESTIMATED name: pCLE-gastr measure: Diagnostic accuracy of pCLE and endoscopic biopsy in diagnosing the whole gastric lesion measure: The histological upstaging rate of pCLE and endoscopic biopsy in diagnosing the whole gastric lesion sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology status: RECRUITING city: Wuhan state: Hubei zip: 430030 country: China name: Bin Cheng, Professor role: CONTACT phone: 86-027-8366-3333 email: bcheng@tjh.tjmu.edu.cn name: Yilin Gu role: CONTACT phone: 86-19884836004 email: yilingu2019@163.com lat: 30.58333 lon: 114.26667 hasResults: False
nctId: NCT06389435 id: 2024DS id: Knee type: OTHER domain: Danderyds sjukhus briefTitle: RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques acronym: ROCKETS overallStatus: RECRUITING date: 2024-03-04 date: 2027-01 date: 2028-01 date: 2024-04-29 date: 2024-04-29 name: Danderyd Hospital class: OTHER name: Karolinska Institutet name: Stockholm South General Hospital briefSummary: Rationale for conducting the study:
The study aims to systematically evaluate the clinical and economic impacts of Robotic-Assisted Total Knee Replacement (RTKR) compared to conventional Total Knee Replacement (TKR). It focuses on the potential benefits of RTKR, including improved precision in surgery, potentially leading to better patient outcomes and reduced healthcare costs. Our primary endpoint is the Forgotten Joint Score (FJS), aimed at measuring patients awareness of their knee joint in everyday life, indicating the success of the knee replacement surgery in restoring natural joint function. Secondary endpoints include patient-reported outcome measures (PROMs), patient activity levels, the accuracy of implant positioning on x-ray, and the incidence of adverse events.
The Forgotten Joint Score (FJS) at 2 years after surgery conditions: Knee Arthroplasty, Total conditions: Robotic-assisted conditions: Osteoarthritis of the Knee studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 250 type: ESTIMATED name: Patients will be randomized to undergo TKR or RTKR measure: The Forgotten Joint Score (FJS) measure: KOOS measure: ADLS knee instability measure: The Forgotten Joint Score (FJS) measure: EQ-5D measure: Knee alignment measure: Adverse events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Danderyds Sjukhus status: RECRUITING city: Stockholm zip: 18288 country: Sweden name: Olof Skoldenberg, Md, PhD role: CONTACT phone: 800-555-5555 email: olof.skoldenberg@ki.se name: Olof Skoldenberg, MD, PhD role: PRINCIPAL_INVESTIGATOR name: Karl Erikson, MD, PhD role: SUB_INVESTIGATOR lat: 59.33258 lon: 18.0649 hasResults: False
nctId: NCT06389422 id: NCC4620 briefTitle: Phase II Study of Moderate-dose Hypofractionated RT Combined With Pembrolizumab for HCC With Diffuse Tumor Thrombosis overallStatus: RECRUITING date: 2024-05-01 date: 2026-04-30 date: 2027-04-30 date: 2024-04-29 date: 2024-04-29 name: Cancer Institute and Hospital, Chinese Academy of Medical Sciences class: OTHER briefSummary: This is a single-center, single-arm, open-label study that includes patients meeting the inclusion criteria (liver-GTV volume \< 700ml or estimated liver-GTV V5 \< 300ml) with hepatocellular carcinoma with diffuse tumor thrombosis involving both left and right lobes. All lesions receive moderate-dose hypofractionated intensity-modulated radiotherapy, with a gross tumor dose of 25Gy/5f, and a maximum dose of 35Gy/5f at the tumor center. One week before or during the radiotherapy, patients receive concurrent Pembrolizumab at a dose of 200mg. Subsequently, Pembrolizumab is administered intravenously every 3 weeks. Follow-up examinations are conducted 1-3 months post-radiotherapy. Lenvatinib 4mg may be used for maintenance therapy with Pembrolizumab if there are no contraindications. Maintenance therapy is continued until disease progression or intolerance. The primary endpoint is median overall survival (mOS), and secondary endpoints include objective response rate (ORR), progression-free survival (PFS), and toxicity. conditions: Hepatocellular Carcinoma conditions: Radiotherapy conditions: Pembrolizumab conditions: Tumor Thrombosis studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Moderate-dose Hypofractionated Intensity-modulated Radiotherapy name: Pembrolizumab measure: Median Overall Survival measure: Objective Response Rate measure: Progression-free Survival measure: Toxicity sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciecnces and Peking Union Medical College status: RECRUITING city: Beijing state: Beijing country: China name: Bo Chen, MD role: CONTACT phone: 0086-13240000876 email: chenboo@outlook.com lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06389409 id: Protocollo N.2009 Testicolo briefTitle: Study on the Quality of Life and Functional/Oncological Outcome of Testicular Cancer Patients overallStatus: RECRUITING date: 2010-08-24 date: 2030-09-01 date: 2040-08-31 date: 2024-04-29 date: 2024-04-29 name: IRCCS San Raffaele class: OTHER briefSummary: The research aims to collect data in order to report the main problems related to the testicular cancer; To reach this aim, this study proposes to create a database of the testicular cancer condition.
From this perspective, the aim of this project is the improving of scientific knowledge of the disease and develop appropriate and effective procedures for the diagnosis and treatment of the patient. conditions: Testicular Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 3000 type: ESTIMATED name: Observation of testicular cancer patients measure: Clinical data measure: Adjuvant therapy measure: lactate dehydrogenase measure: Testicular objective examination measure: Testicular objective examination - cysts measure: Testicular objective examination - nodules measure: Testicular objective examination - varicocele measure: Testicular objective examination - hydrocele measure: α-feto protein measure: β human Chorionic Gonadotropin measure: carcinoembryonic antigen sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Ospedale San Raffaele status: RECRUITING city: Milan state: Lombardy zip: 20132 country: Italy name: Alessia d'Arma, PhD role: CONTACT phone: 02 2643 5506 email: darma.alessia@hsr.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06389396 id: CP362 briefTitle: Investigation of a New Rectal Catheter for Users of Transanal Irrigation overallStatus: RECRUITING date: 2024-04-08 date: 2024-06-30 date: 2024-06-30 date: 2024-04-29 date: 2024-04-29 name: Coloplast A/S class: INDUSTRY briefSummary: The clinical investigation is an exploratory, randomised controlled, open-labelled, crossover investigation.
The clinical investigation will be conducted as a multi-centre clinical investigation in two different clinical investigation sites in Denmark. conditions: Bowel Management studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: PREVENTION masking: NONE count: 20 type: ESTIMATED name: CP362 Test Catheter measure: The primary endpoint is: Was it possible to perform transanal irrigation (assessed after irrigation at V1 and V2) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Århus Universitetshospital status: RECRUITING city: Århus state: Jutland zip: 8200 country: Denmark name: Peter Christensen role: CONTACT lat: 56.15674 lon: 10.21076 facility: Amager Hvidovre Hospital status: RECRUITING city: Hvidovre state: Zealand zip: 2650 country: Denmark name: Michael Sørensen role: CONTACT lat: 55.65719 lon: 12.47364 hasResults: False
nctId: NCT06389383 id: 22-0182 briefTitle: Pilot Study - Monitoring the Nasal Microbiome and Viral Respiratory Infections in Newborn Hospitalized in Neonatalogy. acronym: NEONATMICROBIO overallStatus: ACTIVE_NOT_RECRUITING date: 2022-12-21 date: 2023-06-30 date: 2024-12 date: 2024-04-29 date: 2024-04-29 name: University Hospital, Caen class: OTHER briefSummary: The objective of our study is therefore to study the evolution of the respiratory microbiome of hospitalized newborns, its interaction with viral infections and their impacts on the evolution of newborns. conditions: Newborn; Infection studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 38 type: ACTUAL name: Nasal Swab measure: rate of viral infections sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: CAEN University Hospital city: Caen country: France lat: 49.18585 lon: -0.35912 hasResults: False
nctId: NCT06389370 id: knowledge, Attitude, Behaviour briefTitle: ASSESSMENT OF ORAL HEALTH KNOWLEDGE, ATTITUDE AND BEHAVIOUR AND ITS ASSOCIATION WITH SOCIODEMOGRAPHIC FACTORS OF PRECLINICAL AND CLINICAL DENTAL STUDENTS IN CAIRO UNIVERSITY: A CROSS-SECTIONAL STUDY overallStatus: NOT_YET_RECRUITING date: 2024-11-04 date: 2024-11-18 date: 2024-12-03 date: 2024-04-29 date: 2024-04-29 name: Cairo University class: OTHER briefSummary: The knowledge, behaviour and attitude of oral health professionals reflects their awareness and understanding of oral preventive measures, which will have significant impact on their delivery of public oral health promotion in the future. They are expected to set an example for positive oral health behaviour among other college students, family members and their patients. Various external factors like sociodemographic factors like age, gender, marital state, occupation, and number of family members play a major role in oral hygiene. The relationships between various modifiable factors needs to be assesses in a vast manner.
There were some researches about oral health knowledge, behaviour and attitude in correlation to socio-demographic data, of dental students in other countries, but little was known in Egypt. Dental students are expected to play a critical role in instructing public oral health for improving their patient's, families, and friends. In addition, it may pave the way to develop new programs to encourage needful oral health practices. conditions: Oral Health Knowledge, Attitude and Behaviour of Dental Students studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 535 type: ESTIMATED name: HU-DBI questionnaire measure: Increase of dental students KAB by preceding through higher academic levels sex: ALL minimumAge: 17 Years maximumAge: 27 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06389357 id: 1305G2024 briefTitle: Return to School Adaptation Programme for Children With Cancer acronym: web-based overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2024-09-06 date: 2024-11-30 date: 2024-04-29 date: 2024-04-29 name: Gazi University class: OTHER briefSummary: This study is planned to evaluate the effect of back-to-school adaptation programme on social anxiety score, coping score and back-to-school readiness score in children aged 8-17 years who are followed up with a diagnosis of cancer.
H1: Is there a significant difference in children's social anxiety scores before and after the back-to-school adaptation programme? H2: Is there a significant difference in children's coping scores before and after the back-to-school adaptation programme? H3: Is there a significant difference in children's readiness to return to school scores before and after the back-to-school adaptation programme? conditions: Childhood Cancer conditions: ALL, Childhood conditions: AML, Childhood conditions: Lymphoma conditions: Solid Tumor, Childhood studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: The research is a technical/scientific/collaborative action research design. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 35 type: ESTIMATED name: training and counselling measure: social anxiety measure: coping measure: back to school readiness measure: process evaluation sex: ALL minimumAge: 8 Years maximumAge: 17 Years stdAges: CHILD facility: Gizem Cakir city: Ankara state: Cankaya zip: 06490 country: Turkey name: Gizem Cakir, PhD(c) role: CONTACT phone: +905300858879 email: cakirgzem@gmail.com lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06389344 id: lk20240401 briefTitle: Effect of Esketamine on Conscious State in Patients With pDoC overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-31 date: 2026-06-30 date: 2024-04-29 date: 2024-04-29 name: Beijing Tiantan Hospital class: OTHER briefSummary: The goal of this clinical trial is to learn about the effect of intraoperative infusion of subanesthetic dose of esketamine on conscious status in patients with prolonged disorders of consciousness under sevoflurane anesthesia.
Participants will be patients with prolonged disorders of consciousness undergoing surgery with general anesthesia at Beijing Tiantan Hospital. 0.3mg/kg esketamine or saline will be infused will be infused intravenously at a constant speed within 30 min after tracheal intubation/pneumatectomy fixation. Coma recovery scale-revised, Glasgow coma scale, Full Outline of UnResponsiveness scores, SedLine multi-channel electroencephalogram and perioperative adverse events after surgery will be investigated. conditions: Esketamine conditions: Consciousness Disorders studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 116 type: ESTIMATED name: Esketamine name: normal saline measure: Coma recovery scale-revised(CRS-R) measure: Coma recovery scale-revised(CRS-R) measure: Full Outline of UnResponsiveness(FOUR) measure: Glasgow coma scale(GCS) measure: Original EEG measure: Patient state index(PSI) measure: Power spectral density measure: Burst-suppression ratio measure: Spectral edge frequency measure: The incidence of perioperative adverse events sex: ALL minimumAge: 16 Years maximumAge: 65 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False