hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06322407 id: KY2023-263-03-02 briefTitle: Ultrasound-guided Stellate Ganglion Block for Treatment of Chronic Migraine in Adult overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2025-12 date: 2024-03-21 date: 2024-03-21 name: Beijing Tiantan Hospital class: OTHER briefSummary: To assess the 6-months effects and safety of stellate ganglion block(SGB) for Chronic Migraine (CM) patients who failure to undergo preventive therapy and are seeking a more suitable non-pharmacological therapy. conditions: Chronic Migraine studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Parallel Assignment primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Single (Outcomes Assessor) whoMasked: OUTCOMES_ASSESSOR count: 206 type: ESTIMATED name: Stellate Ganglion Block (SGB) name: standardized drug treatment measure: the change from baseline in mean monthly migraine days measure: Proportion of patients achieved≥50% reduction in monthly migraine days measure: Total effective rate measure: The mean Numeric Rating Scale(NRS) score during headache attack measure: Patients satisfaction (PS) measure: The six item headache impact test (HIT-6) measure: the Migraine Disability Assessment score(MIDAS) measure: The Pittsburgh Sleep Quality Index (PSQI) measure: adverse events sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beijing Tiantan Hospital city: Beijing state: Beijing zip: 100050 country: China name: Fang Luo, M.D role: CONTACT phone: +86 13611326978 email: 13611326978@163.com name: Lu Liu role: CONTACT phone: +86 18618418228 email: emmaliulu@163.com lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06322381 id: Reinsertion AT VS ZO in IAT briefTitle: Reinsertion Achilles Tendon VS Zadek Osteotomy in Insertional Achilles Tendinopathy overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-03 date: 2025-04 date: 2024-03-21 date: 2024-03-21 name: Assiut University class: OTHER briefSummary: The aim of this study is to Compare functional outcome and the recovery time of reinsertion of achilles tendon VS zadek osteotomy in insertional achilles tendinopathy. conditions: Insertional Achilles Tendinopathy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 42 type: ESTIMATED name: Reinsertion achilles tendon name: Zadek osteotomy measure: the time needed to return to normal daily activities (functional outcome) assessed by foot and ankle outcome score. measure: Pain assessed by the visual analogue scale. measure: Rate of complications sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06322368 id: DF002 briefTitle: Myofunctional and Respiratory Intervention on Phonation in Stroke overallStatus: RECRUITING date: 2023-12-01 date: 2024-05-01 date: 2024-07-01 date: 2024-03-21 date: 2024-03-21 name: Universidad de Granada class: OTHER briefSummary: Patients with stroke frequently present phonation difficulties. An intervention combining myofunctional and respiratory training is presented in order to improve phonation outcomes. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Myofunctional and respiratory training program name: Range of motion and thermal and mechanical stimulation exercising measure: Volume during monologue measure: Frequency during monologue measure: Volumen during sustained phonation of /s/ sound measure: Communication effectiveness Index measure: Frequency during sustained phonation of /s/ sound measure: Volumen during sustained phonation of /a/ sound measure: Frequency during sustained phonation of /a/ sound sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Health Sciences status: RECRUITING city: Granada zip: 18016 country: Spain name: Irene Cabrera Martos role: CONTACT email: irenecm@ugr.es role: CONTACT phoneExt: Cabrera Martos email: irenecm@ugr.es name: Irene Cabrera Martos role: PRINCIPAL_INVESTIGATOR lat: 37.18817 lon: -3.60667 hasResults: False
nctId: NCT06322355 id: ZSUFR01 briefTitle: Comparison of UFR With QFR in Stable Coronary Artery Disease overallStatus: COMPLETED date: 2018-07-01 date: 2023-12-31 date: 2023-12-31 date: 2024-03-21 date: 2024-03-21 name: Shanghai Zhongshan Hospital class: OTHER briefSummary: Quantitative flow reserve (QFR), derived from coronary angiography, has shown high accuracy in detecting significant lesions. Ultrasonic flow ratio (UFR), a new development from IVUS, integrates physiological estimation with intravascular imaging. Although both QFR and UFR are effective, there's no conclusive evidence favoring one over the other. The study aims to compare UFR and QFR's diagnostic performance against the conventional FFR standard in detecting significant coronary lesions. conditions: Coronary Artery Disease studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 250 type: ACTUAL name: Coronary angiography, Fractional Flow Reserve measurement, Intravascular ultrasound measure: Compare diagnostic performance of QFR with UFR measure: Correlation and agreement between QFR and UFR sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Zhongshan Hospital, Fudan University city: Shanghai zip: 210000 country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06322342 id: RVL-102-23 id: 9R44CA261240-04A1 type: NIH link: https://reporter.nih.gov/quickSearch/9R44CA261240-04A1 briefTitle: Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent overallStatus: RECRUITING date: 2024-04 date: 2025-02 date: 2025-03 date: 2024-03-21 date: 2024-04-09 name: Reveal Pharmaceuticals Inc. class: INDUSTRY name: National Cancer Institute (NCI) briefSummary: The Phase 2 trial will assess safety, tolerability, efficacy, imaging pharmacodynamics, and pharmacokinetics of RVP-001, a novel manganese-based MRI contrast agent, at three escalating dose levels when administered as a single IV bolus to subjects with known gadolinium-enhancing central nervous system (CNS) lesions who have recently had a gadolinium-based contrast agent (GBCA)-enhanced MRI of the brain. conditions: Central Nervous System (CNS) Lesions studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: DIAGNOSTIC masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: RVP-001 measure: Adverse Events measure: Lesion visualization criteria for RVP-001 enhanced MRI compared to unenhanced MRI measure: Lesion visualization criteria for RVP-001 compared to gadolinium-based contrast agent (GBCA) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Yale New Haven Hospital status: NOT_YET_RECRUITING city: New Haven state: Connecticut zip: 06510 country: United States name: Kristin DeFancesco role: CONTACT phone: 203-785-3852 email: kristin.defrancesco@yale.edu name: Amit Mahajan, MD role: PRINCIPAL_INVESTIGATOR lat: 41.30815 lon: -72.92816 facility: Massachusetts General Hospital status: RECRUITING city: Boston state: Massachusetts zip: 02114 country: United States name: Abi Akinniyi role: CONTACT phone: 781-513-0207 email: aakinniyi@mgb.org name: John Chen, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Brigham & Women's Hospital status: RECRUITING city: Boston state: Massachusetts zip: 02115 country: United States name: Cora Nicoll role: CONTACT phone: 617-525-3161 email: cnicoll1@bwh.harvard.edu name: Mathew DeSalvo, MD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Duke University Medical Center status: RECRUITING city: Durham state: North Carolina zip: 27710 country: United States name: Helen Zuleta role: CONTACT phone: 919-613-0226 email: helen.zuleta@duke.edu name: Shruti Raja, M.D. role: PRINCIPAL_INVESTIGATOR lat: 35.99403 lon: -78.89862 hasResults: False
nctId: NCT06322329 id: K 2023-10103 briefTitle: RealMove (Lung): Assessing Tumour Motion With Dynamic MRI acronym: RealMove(lung) overallStatus: RECRUITING date: 2024-03-15 date: 2026-03-17 date: 2036-03-17 date: 2024-03-21 date: 2024-03-21 name: Region Stockholm class: OTHER_GOV name: Uppsala University Hospital briefSummary: The study aims to develop an improved method to tailor the geometric safety margin when treating with stereotactic body radiotherapy (SBRT), to avoid tumour cells being missed during irradiation and to limit the exposure of normal tissues as much as possible. Dynamic magnetic resonance imaging (MRI) is assumed to represent the tumour motion during the respiratory cycle more realistically, compared to 4-dimensional computed tomography (4D CT), thanks to its high temporal resolution and the possibility to image the motion over a longer period of time. Patients receiving SBRT for a pulmonary target located below the level of the carina are included in the study, and the hypothesis will be tested through a comparison of the tumour amplitude measured with each modality. Furthermore, the predictive value of the image series acquired at treatment planning, for the motion patterns observed at each treatment fraction, will be evaluated through repeated 4D CBCT acquisitions. conditions: Lung Tumor studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 150 type: ESTIMATED name: Dynamic MRI measure: Difference in amplitude of the tumour motion, as assessed by dynamic MRI and 4D CT, respectively measure: Difference in amplitude of the tumour motion, assessed at different times (using dynamic MRI and 4D CBCT) measure: Difference in the structure of the probability density function, assessed at different times measure: Anxiety during examinations of tumour motion measure: Overall survival measure: Progression-free survival measure: Grade ≥2 toxicity assessed by CTCAE v.5.0 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Karolinska University Hospital status: RECRUITING city: Stockholm zip: 17176 country: Sweden name: Eva Onjukka, PhD role: CONTACT phone: +46765696744 email: eva.onjukka@ki.se name: Mattias Hedman, MD/PhD role: CONTACT phone: +46812370000 email: mattias.hedman@regionstockholm.se lat: 59.33258 lon: 18.0649 hasResults: False
nctId: NCT06322316 id: MS-492-2022 briefTitle: Analgesic Efficacy of U/S Retrolaminar Block and Erector Spinae Plane Block in MRM overallStatus: COMPLETED date: 2022-10-01 date: 2023-03-01 date: 2023-04-01 date: 2024-03-21 date: 2024-03-21 name: National Cancer Institute, Egypt class: OTHER briefSummary: Modified radical mastectomy (MRM) is the most commonly performed surgical procedure in breast cancer patients and is usually associated with severe postoperative pain. The peripheral nerve block techniques were suggested to reduce acuter post-mastectomy pain. The study compared the analgesic efficacy of retrolaminar block (RLB) and ESPB in patients undergoing MRM. conditions: Breast Neoplasms conditions: Analgesia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: To determine the analgesic effect of ultrasound guided Retrolaminar Block and Erector Spinae Plane Block in patients undergoing modified radical mastectomy regarding the following : 1-Post-operative opioid (morphine) consumption in the 1st 24 hours 2- Postoperative Numeric Pain Rating Scale. 3. Effect on hemodynamics: Mean arterial blood pressure and Heart rate. 4. Intraoperative fentanyl consumption. 5. Duration of analgesic effect primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: The patients will be randomly assigned into two equal comparable groups using computer- generated random numbers in opaque closed envelopes, each of which will include 30 patients. Randomization will be done by statistician and each group of the patient will revealed only when the included patient is transferred to preanesthetic room. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 60 type: ACTUAL name: The Ultrasound-guided Retrolaminar Block Group name: The Ultrasound-guided Erector Spinae Plane Block Group measure: the total morphine consumed postoperatively for 24 hours measure: the total intraoperative fentanyl consumption measure: duration of analgesia measure: postoperative nausea and vomiting PONV as side effect of morphine sex: FEMALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National cancer Insititute Cairo university city: Cairo zip: 11796 country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06322303 id: C-EXP-194-UGR23 briefTitle: Effect of Cannabidiol (CBD) on Vision and Driving overallStatus: ACTIVE_NOT_RECRUITING date: 2023-02-01 date: 2023-09-30 date: 2025-12-31 date: 2024-03-21 date: 2024-03-22 name: Universidad de Granada class: OTHER briefSummary: The use of cannabis with ∆9-tetrahydrocannabinol (THC) content has been shown to have negative effects on vision and driving. The use of other cannabinoids, such as cannabidiol (CBD), which is not attributed with a psychoactive effect, is increasing significantly. This project aims to investigate whether consuming CBD can negatively affect visual function by assessing a wide range of visual parameters and whether these changes may pose a risk for everyday activities such as driving. conditions: Cannabis Use studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: Placebo (CBD 0%) name: CBD 15% name: CBD 30% measure: Change in Overall Driving Performance Score (ODPS) after cannabidiol vaporization measure: Change in motion detection sensitivity after cannabidiol vaporization measure: Change in contrast sensitivity after cannabidiol vaporization measure: Change in visual acuity after cannabidiol vaporization measure: Change in fixations after cannabidiol vaporization measure: Driving simulator: standard deviation of the lateral lane position (SDLP) measure: Distance travelled outside the lane measure: Mean speed measure: Angular velocity of the steering wheel sex: ALL minimumAge: 18 Years maximumAge: 43 Years stdAges: ADULT facility: University of Granada city: Granada zip: 18071 country: Spain lat: 37.18817 lon: -3.60667 hasResults: False
nctId: NCT06322277 id: NETVAC briefTitle: Use of Low-cost Molecular Diagnostic Techniques as a New Surveillance Model for Diseases Preventable by Vaccinations. overallStatus: RECRUITING date: 2021-05-04 date: 2025-02-28 date: 2025-03-31 date: 2024-03-21 date: 2024-03-21 name: Meyer Children's Hospital IRCCS class: OTHER briefSummary: Vaccine-preventable disease (VPD) surveillance should be a priority throughout the world. In Italy, however, there is limited attention to the epidemiology of VPDs, with the consequence that their incidence is largely underestimated. Although notification of vaccine-preventable diseases is mandatory, very often the etiologic agents causing VPDs are not identified the etiological agents causing the major and most severe infectious diseases in childhood. Several reasons underlie the underestimation. For example, not having a good surveillance system does not allow us to organize a sustainable prevention project for example based on on the introduction of new vaccinations. For example the limited use of low-cost high-sensitivity techniques such as real-time PCR, which could, if more widely used, improve pathogen identification with 3 times the sensitivity of standard cultural methods. Therefore, the idea of this multicenter, biological sample study is to take advantage of the regional pediatric network with the goal of improving VPD surveillance and increase awareness of the importance of surveillance of preventable diseases with the vaccine within the pediatric network. conditions: Bacterial Infections studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 1 type: ESTIMATED name: Analysis of biological sample measure: Incidence rate of major VPDs (vaccine-preventable infectious diseases): pertussis, influenza virus, respiratory syncytial virus, S.pneumoniae, N.meningitidis, H.influenzae. measure: Frequency of principal serotype, serogroups of pathogens causative for VPDs. measure: Number of meeting to diffuse the NETVAC results in Tuscany network. sex: ALL minimumAge: 1 Day maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Ospedale San Donato status: RECRUITING city: Arezzo country: Italy name: Marco Martini role: CONTACT email: marco.martini@uslsudest.toscana.it lat: 43.46276 lon: 11.88068 facility: Immunology Laboratory Meyer Children's Hospital, IRCCS status: RECRUITING city: Florence country: Italy name: Chiara Azzari role: CONTACT phone: +390555662542 email: chiara.azzari@unifi.it name: Silvia Ricci role: SUB_INVESTIGATOR lat: 43.77925 lon: 11.24626 facility: Meyer Children's Hospital IRCCS status: RECRUITING city: Florence country: Italy name: Massimo Resti role: CONTACT email: massimo.resti@meyer.it lat: 43.77925 lon: 11.24626 facility: UO Pediatria Universitaria Ospedale S.Chiara status: RECRUITING city: Pisa country: Italy name: Diego peroni role: CONTACT email: diego.peroni@unipi.it lat: 43.70853 lon: 10.4036 hasResults: False
nctId: NCT06322264 id: 2023-05435-01 briefTitle: Promoting Children's Participation in Conventional X-ray Examinations overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2024-12-14 date: 2025-04-04 date: 2024-03-21 date: 2024-04-26 name: Lund University class: OTHER name: Skane University Hospital briefSummary: The goal of this explorative observational study is to map the procedure and child centered approach in the examination for children that undergo conventional X-ray examinations. The main questions aim to answer:
Participants will answer questionnaires about the children's participation in the procedure and the variation in heart rate will be measured on the children who undergo the examinations. conditions: Heart Rate Determination conditions: Patient Participation studyType: OBSERVATIONAL observationalModel: FAMILY_BASED timePerspective: CROSS_SECTIONAL count: 220 type: ESTIMATED name: Measurement of variation in heart rate measure: Variation in heart rate sex: ALL minimumAge: 4 Years maximumAge: 12 Years stdAges: CHILD hasResults: False
nctId: NCT06322251 id: 2023-03399-01 briefTitle: Identification of Interpesonal Violence acronym: ViP overallStatus: RECRUITING date: 2024-04-01 date: 2027-06-30 date: 2028-06-30 date: 2024-03-21 date: 2024-04-29 name: Region Stockholm class: OTHER_GOV name: Linkoeping University name: Karolinska Institutet name: Stockholm University briefSummary: The goal of this study is to increase primary care professional's ability to identify individuals exposed to intimate partner violence (IPV) in primary health care settings.
Focus group interviews with the participating health professionals will be a qualitative complement. The participants will be asked about what intervention they experience as the most effective in increasing the ability to identify victims of IPV. conditions: Primary Health Care conditions: Interpersonal Violence conditions: Youth conditions: Pregnancy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Baseline measure - Number of patients that are identified fo being exposed to violence.
The clinics will randomised to either condition a, b or c. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 200 type: ESTIMATED name: Use of instrument to identify exposure to violence in close relationships measure: Number of identified persons seeking healthcare who have been exposed to violence measure: Number of identified persons seeking healthcae who have been exposed to violence measure: Experiences of health care staff sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Linköping University status: RECRUITING city: Linköping zip: 581 83 country: Sweden name: Mia Barimani, Professor role: CONTACT phone: +46737083163 email: mia.barimani@liu.se name: Wibke Jonas, Ass prof role: CONTACT phone: +46707482518 email: wibke.jonas@ki.se lat: 58.41086 lon: 15.62157 hasResults: False
nctId: NCT06322238 id: 23-008706 briefTitle: Pharmacogenetic Panel to Prevent Adverse Drug Reactions in Daily Primary Care Practice: acronym: PREPARE-Mayo overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2026-04 date: 2024-03-21 date: 2024-03-21 name: Mayo Clinic class: OTHER briefSummary: The purpose of this study is to determine whether the implementation of pre-emptive pharmacogenomic (PGx) testing of a panel of clinically relevant PGx markers, to guide the dose and drug selection for 39 commonly prescribed drugs, will result in an overall reduction in the number of clinically relevant drug-genotype associated ADRs which are causally related to the initial drug of inclusion (referred to as 'index drug'). conditions: Pharmacogenomic Drug Interaction conditions: Side Effect of Drug conditions: Ineffective Drug Action conditions: Drug Metabolism, Poor, CYP2D6-Related conditions: Drug Metabolism, Poor, CYP2C19-Related studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 66 type: ESTIMATED name: PGx panel test measure: Adverse Drug Reaction (ADR) measure: PREPARE-MAYO Clinicians' and pharmacists' Questionnaire. measure: Patient-Reported Outcomes Measurement Information System (PROMIS-10) Global Health Questionnaire sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mayo Clinic city: Rochester state: Minnesota zip: 55902 country: United States name: Elisa Houwink, MD, PhD role: CONTACT phone: 507-319-2037 email: houwink.elisa@mayo.edu name: Mary Johnson role: CONTACT email: johnson.mary15@mayo.edu name: Jessica Wright, PharmD role: SUB_INVESTIGATOR lat: 44.02163 lon: -92.4699 hasResults: False
nctId: NCT06322225 id: 2023YFC2507401 briefTitle: Establishment of Big Data Platform and Biobank for Colorectal Tubular Adenoma Lesions overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-12-31 date: 2026-12-31 date: 2024-03-21 date: 2024-03-21 name: Sixth Affiliated Hospital, Sun Yat-sen University class: OTHER name: National Key Research and Development Program of China briefSummary: Colorectal tubular adenoma is the most common precancerous lesion of colorectal cancer, and the point is that its precise prevention and treatment can reduce the incidence of colorectal cancer.However, the epidemiological characteristics of colorectal tubular adenoma in China are unclear, the rate of missed diagnosis by colonoscopy is high, and the existing diagnosis and treatment techniques are lack of unified quality control standards,which makes it difficult to diagnose and achieve accurate prevention and control. How to improve the precise prevention and treatment of colorectal tubular adenoma and reduce the incidence of colorectal cancer is a major clinical scientific problem that needs to be solved urgently. For this purpose, this study was conducted in colorectal guided by the needs of accurate prevention and treatment of tubular adenoma lesions,and a multi-center colorectal tubular adenoma data management platform and a high-risk population database covering a full range of data including demographic characteristics, lifestyle factors, clinical information, endoscopic data and pathological images were established, biological sample databases of patients with pathological changes and high-risk populations were established, and data quality control and sample quality control standards were formulated standards-based.