hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06374004 id: HU-FTR-MC-01 briefTitle: The Effect of Thoracic Mobilization in Individuals With Subacromial Pain Syndrome overallStatus: ENROLLING_BY_INVITATION date: 2024-04-10 date: 2024-07-05 date: 2024-07-05 date: 2024-04-18 date: 2024-04-18 name: Hacettepe University class: OTHER briefSummary: The purpose of this study is to investigate the effect of six-week thoracic mobilization on pain intensity, muscle tone, functional and muscle activation in individuals with subacromial pain syndrome. conditions: Subacromial Pain Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: One group received exercise therapy and the other group received manual therapy (thoracic mobilization) in addition to exercise therapy primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Participants will be randomly divided into two groups and participants will not know which group participants are in. whoMasked: PARTICIPANT count: 32 type: ESTIMATED name: Exercise Group name: Thoracic Mobilization Group measure: Electromyography (EMG) measure: Acromiohumeral Distance (AHD) measure: Muscle Tone measure: Functional Activity Level measure: Pain Intensity sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Hacettepe University, Faculty of Physical Therapy and Rehabilitation city: Ankara zip: 06100 country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06373991 id: EDI-901-SLE01 briefTitle: A Study to Evaluate the Safety and Efficacy of ATHENA CAR-T in Subjects With Systemic Lupus Erythematosus overallStatus: RECRUITING date: 2024-04-24 date: 2027-04-30 date: 2027-04-30 date: 2024-04-18 date: 2024-04-29 name: EdiGene Inc. class: INDUSTRY name: The First Affiliated Hospital of Henan University of Science and Technology name: Changping Laboratory briefSummary: The goal of this clinical trial is to test ATHENA CAR-T injection in adults with moderate to severe Systemic Lupus Erythematosus. The main question it aims to answer is:
After screening, participants will be subjected to lymphodepletion regimen. After recovery, participants will be injected with ATHENA CAR-T injection and followed up to 24 months. conditions: Lupus Erythematosus, Systemic studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: ATHENA CAR-T name: Fludarabine name: Cyclophosphamide measure: Dose Limiting Toxicity measure: Frequency of AEs, SAEs, lab abnormalities, AESIs measure: Efficacy: Percent of patients achieved SRI-4 measure: Efficacy: Patients SLEDAI-2000 change compared with baseline measure: Efficacy: Patients BILAG-2004 change compared with baseline measure: Efficacy: Percent of patients' PGA not worsen measure: Percent of patients responded by BILAG-2004 measure: Efficacy: Immunologic parameters measure: Efficacy: Immunologic parameters (cont) measure: PK characteristics measure: PK characteristics (cont) measure: PK characteristics (cont) measure: PD characteristics measure: PD characteristics (cont) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The First Affiliated Hospital of Henan University of Science and Technology status: RECRUITING city: Luoyang state: Henan zip: 471003 country: China name: Muchen Liu role: CONTACT phone: (86)-13663884080 lat: 34.68361 lon: 112.45361 hasResults: False
nctId: NCT06373978 id: 24-307 briefTitle: NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-06-01 date: 2025-12-01 date: 2024-04-18 date: 2024-04-18 name: The Cleveland Clinic class: OTHER briefSummary: This study is a double-blind, randomized controlled trial comparing the effectiveness of oral Diclofenac and Tramadol in reducing the consumption of narcotic pills (primary outcome) and minimizing patients\' exposure to narcotics (secondary outcome) following an ultrasound-guided percutaneous needle tenotomy procedure on the lateral elbow.
The third objective is to uphold consistent early recovery outcomes as measured by the Patient-Rated Tennis Elbow Evaluation (PRTEE) and Quick Disability of Arm, Shoulder, and Hand (QuickDASH) scores after percutaneous needle tenotomy of the lateral elbow, while also investigating the relationship between resiliency and pain catastrophizing in relation to Tramadol usage and response to Diclofenac. conditions: Elbow Pain conditions: Chronic Pain studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This study will be a double-blind, randomized trial comparing a control group receiving the standard care narcotic Tramadol (50mg) to an experimental group receiving Diclofenac (50mg). primaryPurpose: SUPPORTIVE_CARE masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 92 type: ESTIMATED name: Diclofenac name: Tramadol measure: Number of pills taken measure: Non narcotic use sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Cleveland Clinic Florida city: Coral Springs state: Florida zip: 33067 country: United States name: Jennifer Baldwin role: CONTACT phone: 216-390-5833 email: baldwij3@ccf.org name: Alison Klika role: CONTACT phone: 216 444-4954 email: klikaa@ccf.org name: Michael Dakkak, DO role: PRINCIPAL_INVESTIGATOR lat: 26.27119 lon: -80.2706 facility: The Cleveland Clinic Ohio city: Avon state: Ohio zip: 44011 country: United States name: Jennifer Baldwin role: CONTACT phone: 216-390-5833 email: baldwij3@ccf.org name: Jason Genin, DO role: SUB_INVESTIGATOR name: Vikas Patel, DO role: SUB_INVESTIGATOR lat: 41.45171 lon: -82.03542 hasResults: False
nctId: NCT06373965 id: B2024-000 briefTitle: Integrated Online-to-offline (O2O) Model of Care for HIV Prevention and Treatment Among Transgender Women (CINTAI) overallStatus: NOT_YET_RECRUITING date: 2024-05-19 date: 2025-01-06 date: 2025-02-18 date: 2024-04-18 date: 2024-04-18 name: University of Connecticut class: OTHER name: University of Malaya briefSummary: The proposed research focuses on developing and testing a web-based platform, called Jom-TestPlus, that will incorporate HIV self-testing (HIVST) with real-time e-counseling (eHIVST) with online-to-offline (O2O) linkage to HIV prevention and treatment services while simultaneously co-addressing chemsex-related needs for transgender women (TGW) in Malaysia. This model represents a potentially impactful strategy for reaching marginalized populations, like TGW, and allows immediate engagement in the post-test linkage process to prevention or treatment services. conditions: HIV Prevention Program studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 50 type: ESTIMATED name: Online to offline counseling measure: HIVST uptake measure: Linkage to PrEP measure: Linkage to HIV treatment services sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre of Excellence For Research in AIDS (CERiA) city: Kuala Lumpur country: Malaysia lat: 3.1412 lon: 101.68653 hasResults: False
nctId: NCT06373952 id: 23-08-658-910 briefTitle: Integrated Online-to-offline (O2O) Model of Care for HIV Prevention and Treatment Among Men Who Have Sex With Men acronym: CINTAI overallStatus: NOT_YET_RECRUITING date: 2024-05-19 date: 2025-01-06 date: 2025-02-18 date: 2024-04-18 date: 2024-04-22 name: University of Connecticut class: OTHER name: University of Malaya briefSummary: The proposed research focuses on developing and testing a web-based platform, called Jom-TestPlus, that will incorporate HIV self-testing (HIVST) with real-time e-counseling (eHIVST) with online-to-offline (O2O) linkage to HIV prevention and treatment services while simultaneously co-addressing chemsex-related needs for men who have sex with men (MSM) in Malaysia. This model represents a potentially impactful strategy for reaching marginalized populations, like MSM, and allows immediate engagement in the post-test linkage process to prevention or treatment services. conditions: HIV Prevention Program studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 78 type: ESTIMATED name: Online to offline counseling measure: HIVST uptake measure: Linkage to PrEP measure: Linkage to HIV treatment services sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre of Excellence For Research in AIDS (CERiA) city: Kuala Lumpur country: Malaysia lat: 3.1412 lon: 101.68653 hasResults: False
nctId: NCT06373939 id: Pneumoscope study briefTitle: Performance and Safety of the Pneumoscope Device in Adults and Children overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-12-31 date: 2024-12-31 date: 2024-04-18 date: 2024-04-18 name: Pediatric Clinical Research Platform class: OTHER name: University Hospital, Geneva briefSummary: Respiratory diseases are associated with high morbidity and mortality worldwide. Proper diagnosis and risk assessment of these conditions are essential for optimal management. Clinicians use three particularly useful tools to identify these conditions when assessing the patient's status: the stethoscope, the pulse oximeter, and the thermometer. The Pneumoscope is an all-in-one device including a digital stethoscope, a pulse oximeter, and a thermometer. This study aims to assess the performance and safety of the Pneumoscope in recording respiratory sounds, body temperature, non-invasive blood oxygen saturation levels and heart rate in children and adults. conditions: Respiratory Diseases conditions: Pneumonia conditions: Asthma conditions: Cyanotic Heart Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This single center, open, non-controlled investigation will be conducted at one site; the University Hospitals of Geneva, Switzerland. This will be a non-inferiority study between Pneumoscope and CE marked comparable medical devices in children and adults. primaryPurpose: OTHER masking: NONE count: 225 type: ESTIMATED name: Digital lung auscultation name: Pulse oximetry measurement name: Non invasive body temperature measurement measure: Evaluation of Pneumoscope's built-in sensors measure: Collect audio records of lung sounds for AI models training and sensor calibration measure: Pulse oximetry measure: Body temperature sex: ALL minimumAge: 1 Year stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Geneva University Hospitals city: Geneva zip: 1205 country: Switzerland name: Alain Gervaix, Prof role: CONTACT phone: (0)22 372 45 55 phoneExt: +41 email: Alain.Gervaix@hcuge.ch name: Johan Siebert, MD role: CONTACT phone: (0)79 553 40 72 phoneExt: +41 email: Johan.Siebert@hcuge.ch name: Johan N Siebert, MD role: PRINCIPAL_INVESTIGATOR name: Laurence Lacroix-Duccardonnoy, MD role: SUB_INVESTIGATOR name: Isabelle Ruchonnet-Métrailler, MD role: SUB_INVESTIGATOR lat: 46.20222 lon: 6.14569 hasResults: False
nctId: NCT06373926 id: PI2019_843_0010 briefTitle: Evaluation of Cell Membrane Expression of Annexin A2 on Monocytes by Flow Cytometry in Primary Antiphospholipid Syndrome acronym: MONOCYTAN overallStatus: RECRUITING date: 2023-03-28 date: 2025-03 date: 2025-03 date: 2024-04-18 date: 2024-04-18 name: Centre Hospitalier Universitaire, Amiens class: OTHER briefSummary: Annexin A2 (ANXA2), an endothelial cell receptor for plasminogen and tissue plasminogen activator, plays a pivotal role in regulation of fibrinolysis in vitro and in vivo and has been identified as a new autoantigen in antiphospholipid syndrome (APS). ANXA2 can exist as a monomer or a heterotetrameric complex with S100A10 protein. The aim of this study was to evaluate the cell membrane expression of ANXA2 on circulating monocytes in APS by flow cytometry. Several pathogenic mechanisms are involved in APS such as activation of endothelial cells, platelets and monocytes, inhibition of the natural anticoagulant protein C/protein S pathway, activation of the complement system and also impairment of fibrinolysis. Annexin A2 which hits binding partner S100A10, ANXA2 forms a cell surface complex that regulates generation of plasmin. ANXA2 is involved in the pathogenesis of APS-associated through several possible mechanisms. Human peripheral blood monocytes represent the major circulating ANXA2-expressing cell and ANXA2-mediated assembly of plasminogen and tissue activator of plasminogen (tPA) on monocyte/macrophages contributes to plasmin generation. Thus the investigators could suppose that decrease of cell membrane expression of ANXA2 on circulating monocytes represent a new pathogenic mechanism in APS. conditions: Antiphospholipid Syndrome studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 60 type: ESTIMATED name: blood withdrawal measure: Cell membrane expression rate of ANXA2 on circulating monocytes in APS measure: Cellular expression of ANXA2 and S100A10 in APS patients measure: cell membrane expression of ANXA2 and S100A10 in APS patients sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU Amiens status: RECRUITING city: Amiens zip: 80054 country: France name: Valéry SALLE, MD role: CONTACT phone: +33 3 22 66 82 30 email: salle.valery@chu-amiens.fr lat: 49.9 lon: 2.3 hasResults: False
nctId: NCT06373913 id: MASP2NSRZL briefTitle: The Role of Proprotein-convertase-subtilisin/Kexin-type 9 in Kidney Damage in Nephrotic Syndrom acronym: PCSK9 overallStatus: RECRUITING date: 2023-06-01 date: 2027-07-30 date: 2028-07-30 date: 2024-04-18 date: 2024-04-18 name: Kolding Sygehus class: OTHER name: Odense University Hospital name: Vejle Hospital briefSummary: Nephrotic syndrome (NS) is characterized by gross proteinuria (\>3.5 g/day), hypoalbuminaemia, edema and often hyperlipidemia. Hyperlipidemia is correlated with increased morbidity and mortality.
The study will compare plasma levels of PCSK9 in correlation with degree of protein in the urine between test persons with NS and kidney healthy controls. Furthermore the investigators will study the the degree of PCSK9 in the kidney in biopsies obtained from test persons with nephrotic syndrome and test persons without proteinuria. conditions: Hyperlipidemias conditions: Nephrotic Syndrome studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 75 type: ESTIMATED measure: Plasma PCSK9 correlated to the degree of protein in the urine measure: Degree of PCSK9 in kidney tissue measure: Localization of PCSK9 in kidney tissue sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kolding Sygehus, Lillebælt Hospital status: RECRUITING city: Kolding zip: 6000 country: Denmark name: Rikke Z Langkilde, md, phd role: CONTACT phone: 004576362554 name: Anne D Thuesen, md, phd role: CONTACT phone: 004576360555 email: Anne.Daugaard.Thuesen2@rsyd.dk lat: 55.4904 lon: 9.47216 hasResults: False
nctId: NCT06373900 id: IndusH briefTitle: Wound Closure After Total Knee Arthroplasty: Comparison of Polypropylene and Polyglactin 910 Suture. overallStatus: COMPLETED date: 2022-02-13 date: 2022-02-19 date: 2022-03-30 date: 2024-04-18 date: 2024-04-18 name: Indus Hospital and Health Network class: OTHER briefSummary: Comparison of wound complication and scar formation in patient undergone bilateral total knee replacement comparison between polypropylene and polyglactin 910 suture. patient randomised according to SNOS protocol into group A and B for their right and left knee closure with each suture. patient followed on 3rd, 7th, 15th and 30th post operative day for wound healing, wound dehiscence and scar formation. conditions: Wound Heal conditions: Wound Dehiscence conditions: Wound Complication studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE maskingDescription: SNOS protocol whoMasked: PARTICIPANT count: 40 type: ACTUAL name: wound closure measure: Wound characteristics and complications measure: Wound Infection Grade measure: Hollander Cosmetic Wound Evaluation Score sex: ALL minimumAge: 50 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Indus Hospital and Health Network city: Karachi state: Sindh zip: 74900 country: Pakistan lat: 24.8608 lon: 67.0104 typeAbbrev: Prot_SAP_ICF hasProtocol: True hasSap: True hasIcf: True label: Study Protocol, Statistical Analysis Plan, and Informed Consent Form date: 2022-02-04 uploadDate: 2024-04-03T02:55 filename: Prot_SAP_ICF_000.pdf size: 130365 hasResults: False
nctId: NCT06373887 id: 2023-09-005A briefTitle: The Efficacy of Weight-loss Diet Decision-making Based on Initial Gut Metabolic Modules (GMMs) overallStatus: RECRUITING date: 2024-04-10 date: 2024-11-29 date: 2024-12-31 date: 2024-04-18 date: 2024-04-18 name: Taipei Veterans General Hospital, Taiwan class: OTHER_GOV briefSummary: In recent years, the technology to detect the gut microbiome's function has become increasingly developed. GMMs are tools (GitHub - raeslab/GMMs: A manually curated database of human gut metabolic modules.) for describing metabolic pathways for linking microbial metabolic function to species associated with a single metabolite, helping to analyze the transcriptional characteristics and metabolic functions of each bacterium, and studying their role of the food chain in the ecosystem. According to our previous research, the group with good weight loss response (more than 10% body weight loss in 8 weeks) after low-carb diet intervention has higher Shannon's diversity and carbohydrate degradation activity test by GMMs, implying the deficiency of availability of energy sources may cause more weight changes.
Based on the above research, we designed a low-carb diet (rich in monounsaturated fatty acids) and a low-fat diet (whole grains) with the same calories as a means of weight loss. The primary purpose of this study is to evaluate the pre-GMM test for determines the weight loss benefit of the intervention diet. Furthermore, we try to found the possible mechanism of whether metabolites of microbiota (e.g. SCFA) could affect the immune cell change which modulates adipose tissue . conditions: Weight Loss studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: To compare the weight-loss efficacy of different carbohydrate degradation status under two different diet arm (low carbohydrate or low fat diet) to evaluate the benefits of initial gut microbiota profiling in precision weight loss dietary interventions. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE maskingDescription: Single-blinded count: 150 type: ESTIMATED name: plant-based Low carbohydrate diet name: plant-based Low low fat diet measure: Body weight loss/fat mass loss measure: microbiota change sex: ALL minimumAge: 20 Years maximumAge: 64 Years stdAges: ADULT facility: Taipei Veterans General Hospital status: RECRUITING city: Taipei state: Beitou District zip: 11217 country: Taiwan name: Chun-Ying Wu role: CONTACT phone: +886-28712121 phoneExt: 4190 email: chptaiwan07@gmail.com name: HSIAO-PING CHEN role: CONTACT phone: +886-28712121 phoneExt: 4190 email: chptaiwan07@gmail.com lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06373874 id: MCBU-SBF-YC-04 briefTitle: The Effect of High Reality Simulation Environment on the Skills of Midwifery Students, in Newborn Heel Blood Collection overallStatus: COMPLETED date: 2023-04-01 date: 2023-05-30 date: 2023-05-30 date: 2024-04-18 date: 2024-04-18 name: Celal Bayar University class: OTHER briefSummary: The researchers gave midwifery students theoretical training on how to take heel blood on a newborn model. Students were asked to take heel blood on the model in the high-reality simulation environment and simulation room. The student's ability to take heel blood before and after taking heel blood in a high-reality simulation environment or on a newborn model in a simulation environment, satisfaction with learning, anxiety and self-efficacy levels were compared. conditions: Students conditions: Educational Problems conditions: Anxiety studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Parallel Assignment experimental study with experimental and control group primaryPurpose: OTHER masking: NONE count: 92 type: ACTUAL name: Heel blood collection in a newborn simulation model measure: Skill checklist measure: State and Trait Anxiety Scales measure: Self-Efficacy Scale measure: Student Satisfaction and Self-Confidence in Learning Questionnaire sex: FEMALE minimumAge: 21 Years maximumAge: 32 Years stdAges: ADULT facility: Manisa Celal Bayar University Faculty of Health Sciences, Department of Midwifery city: Manisa zip: 45140 country: Turkey lat: 38.61202 lon: 27.42647 facility: Yonca çiçek okuyan city: Manisa zip: 45140 country: Turkey lat: 38.61202 lon: 27.42647 hasResults: False
nctId: NCT06373861 id: 20-0482 briefTitle: Generating Advancements Through Longitudinal Analysis in X and Y Variations (GALAXY) acronym: GALAXY overallStatus: RECRUITING date: 2022-04-28 date: 2037-04 date: 2037-04 date: 2024-04-18 date: 2024-04-18 name: University of Colorado, Denver class: OTHER name: Children's Hospital Colorado briefSummary: GALAXY is a registry research study that plans to learn more about individuals with X\&Y variations (also called sex chromosome aneuploidies) through collecting information from medical records.This includes genetic tests, imaging, medications, and more for hundreds of patients seen at a number of clinics across the US. The purpose of the GALAXY Registry is to collect and store this information with the overall goal to improve health outcomes in individuals with X\&Y variations and the care they receive. conditions: Sex Chromosome Aneuploidy studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 5000 type: ESTIMATED name: no intervention measure: Health Conditions measure: Prevalence of mental health diagnoses measure: Cardiometabolic diagnoses - prevalence of obesity measure: Cardiometabolic diagnoses - prevalence of dyslipidemia measure: Cardiometabolic diagnoses-prevalence of hypertension measure: Autoimmune diagnoses - prevalence of hypothyroidism and of hyperthyroidism measure: Autoimmune diagnoses - prevalence of diabetes sex: ALL minimumAge: 0 Days maximumAge: 100 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Children's Hospital Colorado status: RECRUITING city: Aurora state: Colorado zip: 80045 country: United States name: Shanlee M Davis, MD, PhD role: CONTACT phone: 720-777-6073 email: shanlee.davis@childrenscolorado.org lat: 39.72943 lon: -104.83192 hasResults: False