hackint0sh/New-Dataset huggingface dataset:
GynCAT is a prospective cohort study that will be conducted on female patients with gynecologic malignancies scheduled for systemic antineoplastic treatment. During the screening phase, symptomatic VTE will be excluded, and KRS will be assessed. Pharmacological thromboprophylaxis will be considered and prescribed at clinical judgement, for patients with a KRS score of 3 or higher. Clinical, hematological, biochemical, coagulation, and genetic variables will be collected. Follow-up will last for the entire duration of the antineoplastic treatment line, and VTE events, bleeding events, and mortality will be recorded.
The sample size calculation is based on an estimated VTE incidence of 5% over a mean follow-up of 12 months. Hence, a sample size of at least 1,200 patients in the derivation cohort is considered sufficient for the determination of a risk prediction model incorporating up to six predictor variables. A split-sample method will be used, with two-thirds of the study participants randomly assigned to the model derivation cohort (n=1,200) and one-third (n=600) to an independent validation cohort. The total number of patients recruited in the study will thus be of 1,800. A competing risk survival analysis with Fine \& Gray model will be used to study the association between prognostic variables and VTE occurrence, considering death as a competitive risk. The RPM will be identified through a bootstrap approach to reduce the risk of overfitting. Discrimination power of the RPM will be assessed using time-dependent Receiving Operating Characteristic curve, and model calibration will be evaluated graphically and with the calculation of relative calibration slopes.
In conclusion, this prospective cohort study aims to overcome the limitations of current RPMs in gynecologic cancer patients, improving the accuracy of VTE risk stratification in this population. conditions: Cancer-associated Thrombosis conditions: Venous Thromboembolism conditions: Gynecologic Cancer conditions: Ovarian Cancer conditions: Cervix Cancer conditions: Endometrial Cancer conditions: Vaginal Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1800 type: ESTIMATED name: Anticoagulant measure: Venous thromboembolism measure: Bleeding sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione Policlinico Universitario A. Gemelli IRCCS city: Rome zip: 00168 country: Italy lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06284330 id: STU-2023-0881 briefTitle: CHARGE Study: CHoice ARchitecture Genetic tEsting acronym: CHARGE overallStatus: RECRUITING date: 2024-02-16 date: 2025-03 date: 2025-08 date: 2024-02-28 date: 2024-04-05 name: University of Texas Southwestern Medical Center class: OTHER briefSummary: CHARGE is a hybrid type I feasibility study to compare a choice architecture intervention for cascade genetic testing to usual care. conditions: Hereditary Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 260 type: ESTIMATED name: Enhanced cascade testing measure: Rate of cascade genetic testing measure: Change in probands' family communication about genetic test results as measured by Proband survey measure: Proband's and relative's satisfaction with decision about participating in study measured at approximately 4- 7 months measure: Family functioning as reported by probands and relatives measured by Cancer Family Impact Scale measure: Proband's reaction to intervention materials as measured by proband survey. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UT Southwestern Medical Center status: RECRUITING city: Dallas state: Texas zip: 75390 country: United States name: Sukh Makhnoon, PhD, MS role: CONTACT phone: 214-648-3242 email: Chargestudy@utsouthwestern.edu name: Sukh Makhnoon, PhD, MS role: PRINCIPAL_INVESTIGATOR lat: 32.78306 lon: -96.80667 hasResults: False
nctId: NCT06284317 id: ETOP 25-23 briefTitle: A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients With Early-stage, Operable, Non-small Cell Lung Cancer. acronym: ADOPT-lung overallStatus: NOT_YET_RECRUITING date: 2024-10 date: 2029-10 date: 2030-03 date: 2024-02-28 date: 2024-04-05 name: ETOP IBCSG Partners Foundation class: NETWORK name: AstraZeneca AG Switzerland briefSummary: ADOPT-LUNG is an international, multicentre, open-label randomised phase III trial. Protocol treatment consists of 3-4 cycles of neoadjuvant durvalumab in combination with platinum-based doublet chemotherapy, followed by surgery. Patients with R0 and R1 only resection will be randomised to receive either adjuvant durvalumab for 12 cycles (experimental arm) or observation (control arm). The primary objective of the study is to determine whether additional adjuvant immunotherapy with durvalumab after neoadjuvant chemo-immunotherapy has an effect on disease-free survival (DFS) in patients who do not achieve complete pathological response (pCR) as per local assessment according to the IASLC recommendations. conditions: Non Small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 290 type: ESTIMATED name: Adjuvant durvalumab measure: Disease-free survival (DFS) measure: Response rate as per investigator assessment. measure: Proportion of patients undergoing surgery measure: Proportion of patients with surgical outcome R0 and R1 measure: pCR rate measure: Proportion of patients eligible for randomisation measure: Proportion of patients effectively randomised measure: Toxicity according to CTCAE v5.0 measure: DFS in patients with pCR measure: Overall survival (OS) in patients with/without pCR measure: DFS in patients with/without ctDNA clearance measure: Time to recurrence (TTR) in patients with/without pCR measure: Time to treatment discontinuation (TTD) in patients with/without pCR measure: Toxicity according to CTCAE v5.0 measure: Correlation between ctDNA clearance and pathological response measure: Correlation between ctDNA clearance and DFS measure: Correlation between ctDNA clearance and OS measure: Correlation between ctDNA clearance and initial PD-L1 assessment measure: Outcome (OS) measure: Outcome (event-free survival) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06284304 id: N22DES briefTitle: A Pilot Study of Dose dE-eScalaTion IN prostATe radIOtherapy usiNg the MRL acronym: DESTINATION overallStatus: RECRUITING date: 2024-02-29 date: 2025-04-01 date: 2027-04-01 date: 2024-02-28 date: 2024-03-05 name: The Netherlands Cancer Institute class: OTHER briefSummary: Trial design: A single centre phase II non-randomised study
Trial treatment: All radiotherapy will be delivered on the MR-linac. Intraprostatic dose will be varied according to risk of local recurrence, based on mpMRI, PSA and histology. The whole prostate will receive 30 Gy in 5 fractions and the GTV plus intra-prostatic margin will receive an isotoxic 45 Gy prescription. conditions: Prostate Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: De-escalated radiotherapy measure: Technical feasibility of treating prostate cancer with toxicity minimising radiotherapy on a MR-linac measure: Acute GU toxicity measure: Acute GI toxicity measure: Late GU toxicity measure: Late GI toxicity measure: PROMs measure: Biochemical free survival sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Netherlands Cancer Institute status: RECRUITING city: Amsterdam zip: 1066CX country: Netherlands name: Floris Pos, MD PhD role: CONTACT phone: +31 20 512 9111 email: f.pos@nki.nl lat: 52.37403 lon: 4.88969 hasResults: False
nctId: NCT06284291 id: TMSpath id: RF-2021-12372804 type: OTHER_GRANT domain: Italian Ministry of Health briefTitle: Transcranial Magnetic Stimulation (TMS) in Genetic Epilepsies overallStatus: RECRUITING date: 2023-11-22 date: 2025-11-30 date: 2026-03-01 date: 2024-02-28 date: 2024-02-28 name: Meyer Children's Hospital IRCCS class: OTHER briefSummary: Transcranial magnetic stimulation (TMS) uses electromagnetic induction as an efficient, painless, non-invasive method to generate a suprathreshold current at the level of the encephalon, and provide in vivo measurements of cortical excitability and reactivity at the level of the motor cortex (TMS-EMG) or the entire cortical mantle (TMS-EEG). This study proposes TMS measurements as a diagnostic tool in patients to understand mechanisms of epileptogenesis related to genetic mutations, and prognostic to guide and monitor precision treatments. conditions: Epilepsy conditions: Genetic Disease studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 150 type: ESTIMATED name: transcranial magnetic stimulation (TMS) measure: Resting motor threshold measure: SICI measure: ICF measure: LICI measure: TEP amplitude measure: TEP latency sex: ALL minimumAge: 3 Years maximumAge: 70 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Meyer Children's Hospital IRCCS status: RECRUITING city: Firenze country: Italy name: Simona Balestrini, MD role: CONTACT email: simona.balestrini@meyer.it lat: 43.77925 lon: 11.24626 hasResults: False
nctId: NCT06284278 id: NCKU_PPGP_diaphragm briefTitle: Telehealth: Diaphragmatic vs. Pelvic Exercise in Postpartum Pregnancy-related Pelvic Girdle Pain overallStatus: RECRUITING date: 2023-10-20 date: 2024-05-31 date: 2024-07-31 date: 2024-02-28 date: 2024-02-28 name: YI-JU TSAI class: OTHER briefSummary: The goal of this interventional study is to compare investigate the short-term and long-term effects of 8-week real-time telehealth-based diaphragmatic breathing exercise and pelvic stabilization exercise on pain, disability, and quality of life in postpartum women with pregnancy-related pelvic girdle pain. conditions: Postpartum conditions: Pregnancy Related conditions: Pelvic Girdle Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: Diaphragmatic breathing retraining name: Pelvic stabilization exercise name: pelvic anatomy education measure: Muscle function measures of lumbopelvic muscles measure: Diaphragm thickness measure: Diaphragm mobility measure: Diaphragm strength measure: Mechanical Property of Thoracolumbar Fascia measure: Functional performance of ASLR fatigue task measure: Functional performance of timed up and go test measure: Functional performance of 6m timed walk test measure: pain intensity measure of Numeric Rating Scale (NRS) measure: Disability Level: measure of pelvic girdle questionnaire(PGQ) measure: Health-related Quality of Life: Short Form-36 (SF36) measure: Fear Avoidance Belief: Tampa Scale of Kinesiophobia measure: Self-Efficacy: Pain Self-efficacy Questionnaire measure: Parenting Stress Level: Parenting Stress Index-Short Form (PSI-SF) measure: Self-perceived Change: Global Rating of Change Scale (GROC) sex: FEMALE minimumAge: 20 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Cheng Kung University status: RECRUITING city: Tainan zip: 701 country: Taiwan name: Tsai Yi-Ju role: CONTACT phone: 06-2353535 phoneExt: 5930 email: lulilutsai@gmail.com lat: 22.99083 lon: 120.21333 hasResults: False
nctId: NCT06284252 id: TÜBİTAK-323S135 briefTitle: Virtual Game Simulation on Nursing Students' Physical Examination Skills overallStatus: NOT_YET_RECRUITING date: 2024-09-15 date: 2025-01-15 date: 2025-02-15 date: 2024-02-28 date: 2024-02-28 name: Necmettin Erbakan University class: OTHER name: TÜBİTAK briefSummary: The project is unique in that it will use virtual game simulation, a new learning method, and it will address the physical examination skills of nursing students, an area that has not been researched before. In the project, a randomized controlled research design with a pretest-posttest control group will be used. The population will consist of 200 second-year students enrolled in the Physical Examination in Nursing course at Necmettin Erbakan University, Faculty of Nursing, Department of Nursing, in the 2024-2025 Fall Semester. 120 students from the population who meet the research inclusion criteria will be randomly assigned to control (n=60) and experimental (n=60) groups according to their general academic success score. In collecting data; Introductory characteristics form, skill checklist for physical examination of the heart, skill checklist for physical examination of the abdomen, skill checklist for physical examination of the respiratory system and an evaluation form for the effect of virtual game simulation on skill practice for physical examination will be used. In the project, three different virtual game simulations will be developed for physical examinations of the heart, abdomen and respiratory system. During the fall semester, theoretical and laboratory demonstration applications will be carried out by the project team. A pre-test will be administered to all students, and then virtual game simulations will be made available to students in the experimental group for three weeks. Then, the virtual games will be closed to the students and a post-test will be administered to the experimental and control group students. After the final test application, virtual game simulations will be made available to students in the control group. In pre- and post-test applications, students will practice physical examination skills on simulated patients at three different stations (heart, abdomen and respiratory system) and will be evaluated by the project team according to skill checklists. After the skill evaluations, the students in the experimental group will be given a form to evaluate the effect of the virtual game simulation for physical examination on skill practice and will be asked to fill it out. conditions: Simulation of Physical Illness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Control group and intervention group primaryPurpose: OTHER masking: TRIPLE maskingDescription: Participant blinding: In order to ensure participant blinding, all students will register to the site where virtual game simulations will be hosted.
Researcher blinding: In order to ensure researcher blinding, the expert who designed the web page for virtual game simulations selected the students who registered on the website, using the "A" and "B" codes, according to the list he received from the statistics expert, on the website with a random group as control and one group as experiment. will assign it to the site. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: Virtual Gaming Simulation measure: Skill assessment for physical examination of the abdomen (Pretest) measure: Skill assessment for physical examination of the heart(Pretest) measure: Evaluation of physical examination skills of the respiratory system(Pretest) measure: Skill assessment for physical examination of the abdomen (Posttest) measure: Skill assessment for physical examination of the heart(Posttest) measure: Evaluation of physical examination skills of the respiratory system(Posttest) sex: ALL minimumAge: 19 Years maximumAge: 25 Years stdAges: ADULT hasResults: False
nctId: NCT06284239 id: Tell Me Game briefTitle: Using Games in Teaching Nursing History overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-05 date: 2024-06 date: 2024-02-28 date: 2024-03-21 name: Necmettin Erbakan University class: OTHER briefSummary: Innovative learning methods can be used in teaching nursing history. One of the most preferred among these methods is learning through games. It is known that today's Generation Z students prefer active learning methods and want to learn by having fun instead of learning by rote. It is reported that learning through games improves students' knowledge and skills and increases retention. One of the methods of learning through games is the "tell me" game. The "Tell Me" game involves the narrator explaining the words prepared specifically for the subject to a group of students without using prohibited words. Other students in the group try to know the word explained. Thus, both the student narrator and the student trying to know actively use their critical thinking and decision-making skills. This research aims to determine the effect of the tell-all game used in teaching nursing history on students' learning and opinions. conditions: Education Nursing studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: It refers to the intervention group in which the "Tell Me" game will be played. primaryPurpose: OTHER masking: DOUBLE maskingDescription: Participants will be informed about the research. However, participants will not know which group they belong to. At the same time, the statistical analysis of the research will be carried out by an independent statistician. Thus, blinding of both the participant and the outcome assessor will be ensured. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 66 type: ESTIMATED name: Tell me about the game. measure: Nursing History Knowledge Test measure: Nursing History Teaching Evaluation Form sex: ALL minimumAge: 20 Years maximumAge: 24 Years stdAges: ADULT hasResults: False
nctId: NCT06284226 id: CCT-ANK-11 briefTitle: An Exploratory Clinical Study to Evaluate the Safety and Efficacy of NK Cells (Combined With Standard Therapy) in the Treatment of Solid Tumor Patients acronym: CCT-ANK-11 overallStatus: WITHDRAWN date: 2022-03-25 date: 2025-06-30 date: 2025-12-31 date: 2024-02-28 date: 2024-04-16 name: Beijing Kejing Biotechnology Co., Ltd. class: INDUSTRY briefSummary: An exploratory clinical study to evaluate the safety and efficacy of NK cells (combined with standard therapy) in the treatment of solid tumor patients conditions: Solid Tumors (Pancreatic Cancer, Esophageal Cancer, Gastric Cancer, Cholangiocarcinoma, Lung Cancer and Ovarian Cancer) studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 0 type: ACTUAL name: Allogeneic NK（CCT-ANK-11) measure: To evaluate the safety and the efficacy sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06284213 id: 5U24NS100591 type: NIH link: https://reporter.nih.gov/quickSearch/5U24NS100591 briefTitle: Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium acronym: MarkVCID overallStatus: RECRUITING date: 2021-09-29 date: 2027-07 date: 2027-07 date: 2024-02-28 date: 2024-02-28 name: Massachusetts General Hospital class: OTHER name: Duke University name: Johns Hopkins University name: University of New Mexico name: University of Southern California name: University of Kentucky name: Rush University Medical Center name: University of Maryland, Baltimore name: University of California, San Francisco name: University of California, Los Angeles name: University of California, Davis name: University of Texas name: The University of Texas Health Science Center at San Antonio name: The University of Texas Health Science Center, Houston name: Mayo Clinic name: University of Mississippi Medical Center name: Washington University School of Medicine name: Olive View-UCLA Education & Research Institute briefSummary: Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID) is an NIH-funded consortium dedicated to finding biomarkers involved in age-related thinking and memory problems. Alzheimer's disease and other dementias leave signatures on brain scans or in the blood called biomarkers. The MarkVCID study will measure a panel of candidate biomarkers in 1800 participants and watch them closely to see what they tell us about changes in brain function and risk of memory loss.
nctId: NCT06284200 id: sarcopenia eRA briefTitle: Presence and Comparison of Sarcopenia in Early Rheumatoid Arthritis and Rheumatoid Arthritis overallStatus: RECRUITING date: 2023-06-23 date: 2024-03-23 date: 2024-06-23 date: 2024-02-28 date: 2024-02-28 name: Kayseri City Hospital class: OTHER_GOV briefSummary: introduction: In this study, the presence of sarcopenia in cases with early rheumatoid arthritis and established rheumatoid arthritis will be compared.
Materials and Method: According to the power analysis, 24 patients with early rheumatoid arthritis and 24 patients with established rheumatoid arthritis who meet the 2010 American College of Rheumatology (ACR) / European Alliance of Associations for Rheumatology (EULAR) rheumatoid arthritis (RA) classification criteria will be included in the study. conditions: Sarcopenia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 48 type: ESTIMATED measure: Evaluation of Muscle Mass measure: Evaluation of Muscle Strength measure: Evaluation of Muscle Performance measure: Rheumatoid Arthritis Quality of Life Scale measure: Health Assessment Questionnaire (HAQ) measure: Hospital Anxiety and Depression Scale (HADS) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Health Sciences University, Kayseri Medicine Faculty status: RECRUITING city: Kocasinan state: Kayseri zip: 38125 country: Turkey name: MEHMET KÖKSAL, M.D. role: CONTACT phone: +905514043114 email: dr.mhmtkksl@gmail.com hasResults: False
nctId: NCT06284187 id: KhonKaenH briefTitle: Diagnosis Test of Real-time Polymerase Chain Reaction (RT-PCR) for Pulmonary Tuberculosis overallStatus: COMPLETED date: 2023-01-01 date: 2023-10-31 date: 2023-12-31 date: 2024-02-28 date: 2024-02-28 name: Khon Kaen Hospital class: OTHER_GOV briefSummary: BACKGROUND: Pulmonary tuberculosis remains the leading cause of morbidity and mortality in Thailand. The microbiological detection of TB is important because of early and correct diagnosis, drug resistance testing and ensures that the effective treatment can be achieved and in a timely manner. Mycobacterial culture is the gold standard diagnostic test. Currently, a real-time polymerase chain reaction (RT-PCR) assay, such as Allplex™ MTB/MDRe Detection, Seegene is commonly used.
OBJECTIVE: To evaluate the diagnosis value of the real-time multiplex PCR by using Allplex™ MTB/MDRe Detection kit to detect MTB from sputum specimens with a gold standard TB culture. conditions: Tuberculosis conditions: Pulmonary studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: RETROSPECTIVE count: 120 type: ACTUAL measure: Number of participants with pulmonary TB by Allplex™ MTB/MDRe sex: ALL minimumAge: 15 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Thananit Sangkomkamhang city: Khon Kaen zip: 40000 country: Thailand lat: 16.44671 lon: 102.833 hasResults: False