hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06365112 id: R21154 briefTitle: Endoscopic Acetabulum Surgery overallStatus: RECRUITING date: 2024-04 date: 2026-01 date: 2028-01 date: 2024-04-15 date: 2024-04-24 name: Tampere University Hospital class: OTHER briefSummary: Try to develop an endoscopic surgical technique to treat acetabulum fractures conditions: Acetabulum Fracture studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 13 type: ESTIMATED name: Endoscopy assisted measure: Number of patients with major complications measure: Number of patients with minor complications measure: Operation time measure: Patient satisfaction using EQ5D sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tampere University hospital status: RECRUITING city: Tampere zip: 33521 country: Finland name: Piia Suomalainen role: CONTACT lat: 61.49911 lon: 23.78712 hasResults: False
nctId: NCT06365099 id: STUDY00000896_Exp2 briefTitle: Identifying Personalized Brain States Predicting Residual Corticospinal Tract Output After Stroke overallStatus: RECRUITING date: 2024-02-02 date: 2026-03-31 date: 2026-03-31 date: 2024-04-15 date: 2024-04-15 name: University of Texas at Austin class: OTHER name: Emory University briefSummary: Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and promote poststroke hand motor recovery. To maximize the effects of such interventions, they must be delivered during brain activity patterns during which TMS best activates the residual CST and enhances its neural transmission. This approach is termed brain state-dependent TMS. The investigators have recently developed a machine learning framework that identifies personalized brain activity patterns reflecting strong CST activation in neurotypical adults. In this study, the investigators will apply this framework to the poststroke brain for the first time. They will also evaluate relationships between this framework's ability to detect strong and weak CST activation states and measures of CST pathway integrity.
Participants will visit the laboratory for two days of testing that are separated by at least one night of sleep. On Day 1, participants will provide their informed consent. The MacArthur Competence Assessment Tool and the Frenchay Aphasia Screening Test will be used to evaluate consent capacity and confirm the presence of expressive aphasia as needed. Afterwards, participants will complete eligibility screening and clinical assessment of upper extremity motor impairment, motor function, and disability using the Upper Extremity Fugl-Meyer Assessment, the Wolf Motor Function Test, and the Modified Rankin Scale. Participants will then be screened for the presence of residual CST connections from the lesioned hemisphere to the affected first dorsal interosseous muscle. Recording electrodes will be attached to this muscle in order to record TMS-evoked twitches in these muscles. During this procedure, single-pulse TMS will be applied to each point of a 1 cm resolution grid covering primary and secondary motor areas of the lesioned hemisphere at maximum stimulator output. If TMS reliably elicits a muscle twitch in the affected first dorsal interosseous, that participant will be considered to have residual CST connections and will be eligible for the full study. If no muscle twitch is observed, the participant will not be eligible for the full study. Afterwards, recording electrodes will be removed and the participant will leave the laboratory.
On Day 2, participants will return to the laboratory. The investigators will confirm continued eligibility and place recording electrodes on the scalp using a swim-type cap. The investigators will also place recording electrodes on the affected first dorsal interosseous as well as the affected abductor pollicis brevis and extensor digitorum communis muscles. After identifying the scalp location at which TMS best elicits muscle twitches in the affected first dorsal interosseous muscle, the investigators will determine the lowest possible TMS intensity that such evokes muscle twitches at least half of the time. Then, the investigators will deliver 6 blocks of 100 single TMS pulses while participants rest quietly with their eyes open. Stimulation will be delivered at an intensity that is 20% greater than the lowest possible TMS intensity that evokes muscle twitches at least half the time. Afterwards, all electrodes will be removed, participation will be complete, and participants will leave the laboratory.
The investigators will recruit a total of 20 chronic stroke survivors for this study. conditions: Stroke studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 20 type: ESTIMATED name: Single-pulse TMS measure: Personalized classifier performance measure: Corticospinal tract-lesion overlap sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Texas at Austin status: RECRUITING city: Austin state: Texas zip: 78712 country: United States name: Sara Hussain role: CONTACT phone: 512-232-2686 email: sara.hussain@austin.utexas.edu lat: 30.26715 lon: -97.74306 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-01-10 uploadDate: 2024-04-05T17:22 filename: ICF_000.pdf size: 462079 hasResults: False
nctId: NCT06365086 id: STUDY00000608 briefTitle: Targeting Personalized Brain States Reflecting Strong and Weak Corticospinal Tract Output in Real-time overallStatus: ACTIVE_NOT_RECRUITING date: 2023-01-27 date: 2025-01-01 date: 2025-01-01 date: 2024-04-15 date: 2024-04-15 name: University of Texas at Austin class: OTHER name: Emory University briefSummary: Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic hand function after stroke. To maximize the therapeutic effects of such interventions, they must be delivered during poststroke brain activity patterns during which TMS best activates the residual corticospinal tract and enhances neural transmission within it (i.e., brain state-dependent TMS). In this study, the investigators will test the feasibility of real-time, personalized brain state-dependent TMS in neurotypical adults.
Participants will visit the laboratory for one day of testing. Upon arrival, participants will provide their informed consent; afterwards, they will complete eligibility screening. The investigators will then place recording electrodes on the scalp using a swim-type cap and on the left first dorsal interosseous, abductor pollicis brevis, and extensor digitorum communis muscles. After determining the location at which TMS best elicits muscle twitches in the left first dorsal interosseous, the investigators will determine the lowest possible intensity at which TMS elicits muscle twitches at least half of the time in this muscle. Then, the investigators will deliver 6 blocks of 100 single TMS pulses while the participant rests quietly with their eyes open; stimulation will be delivered at an intensity that is 20% greater than the lowest possible intensity at which TMS elicits muscle twitches at least half of the time. Afterwards, the investigators will use the muscle and brain activity recordings acquired during these 6 blocks to build a personalized mathematical model that identifies which patterns of brain activity correspond to the largest TMS-evoked muscle twitches. The investigators will then use this model to detect the occurrence of these brain activity patterns in real-time; when these patterns are detected, single TMS pulses will be delivered. Afterwards, all recording electrodes will be removed, participation will be complete, and participants will leave the laboratory.
The investigators will recruit a total of 16 neurotypical adults for this study. conditions: Neurotypical Adults studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: CROSSOVER interventionModelDescription: Participants will receive single-pulse TMS during personalized brain activity patterns reflecting either strong or weak corticospinal tract activation primaryPurpose: BASIC_SCIENCE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 16 type: ESTIMATED name: Personalized brain state-dependent single-pulse TMS measure: Motor-evoked potential (MEP) amplitudes elicited from the left first dorsal interosseous muscle during personalized strong and weak CST states measure: State-targeting accuracy sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Texas at Austin city: Austin state: Texas zip: 78712 country: United States lat: 30.26715 lon: -97.74306 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-10-04 uploadDate: 2024-04-05T16:56 filename: ICF_000.pdf size: 305303 hasResults: False
nctId: NCT06365073 id: TJIRB20231276 briefTitle: A Case-control Study on the Clinical Characteristics of 28-day and 90-day Death From Severe Anthrax overallStatus: RECRUITING date: 2024-03-13 date: 2024-08-31 date: 2024-12-31 date: 2024-04-15 date: 2024-04-15 name: Qin Ning class: OTHER briefSummary: This study is a clinical, multi-center, retrospective, case-control study. Patients clinically diagnosed with severe anthrax who meet the inclusion and exclusion criteria will be included in this study for analysis. Respiratory, circulation, nerve and other vital signs of patients with severe anthrax during hospitalization were recorded, and clinical data such as blood routine, blood biochemistry, coagulation function, myocardial injury, therapeutic drug use, and survival time of patients were recorded, as well as the survival situation of patients 28 days and 90 days after discharge. conditions: Anthrax studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 80 type: ESTIMATED measure: mortality rates of severe anthrax measure: incidence of complications measure: Peripheral blood biomarkers associated with 28-day and 90-day mortality measure: the improvement in 28-day and 90-day mortality with treatment for severe anthrax sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology status: RECRUITING city: Wuhan state: Hubei country: China name: Qin Ning, PHD,MD role: CONTACT phone: +8602783662391 email: qning@vip.sina.com name: Qin Ning, PHD,MD role: PRINCIPAL_INVESTIGATOR name: Tao Chen, PHD,MD role: SUB_INVESTIGATOR lat: 30.58333 lon: 114.26667 hasResults: False
nctId: NCT06365047 id: STUDY00004926 briefTitle: Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-06-01 date: 2027-06-01 date: 2024-04-15 date: 2024-04-23 name: Tufts University class: OTHER name: Colgate Palmolive briefSummary: This is a clinical investigation to measure the changes in the oral environment resulting from a 3 month exposure to an arginine containing toothpaste. This study is a double blind, randomized controlled, parallel design. Seventy (70) male and female subjects who meet the inclusion/exclusion criteria will be enrolled in the study. Following oral health evaluations, subjects will be assigned to the treatment schedule and receive their assigned study product. conditions: Xerostomia studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: double blinded whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 70 type: ESTIMATED name: 8% Arginine toothpaste name: 1000 ppm F toothpaste measure: Salivary pH Impact measure: Measuring the change in the oral microbiome sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tufts University School of Dental Medicine city: Boston state: Massachusetts zip: 02111 country: United States lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06365034 id: YKLL-KY-2024（024） briefTitle: Study on the Efficacy and Safety of Conversion Therapy in Patients With Initially Unresectable Hepatocellular Carcinoma overallStatus: RECRUITING date: 2024-03-01 date: 2024-10-01 date: 2025-01-31 date: 2024-04-15 date: 2024-04-15 name: Qianfoshan Hospital class: OTHER briefSummary: To evaluate the efficacy and safety of conversion therapy in patients with initially unresectable hepatocellular carcinoma (uHCC). conditions: Carcinoma, Hepatocellular studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: RETROSPECTIVE count: 92 type: ESTIMATED measure: Pathologic response rate sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: the Qianfoshan Hospital status: RECRUITING city: Jinan state: Shandong zip: 250000 country: China name: Jing Liang, Dr role: CONTACT phone: +8618663761275 email: liangjing0531@163.com lat: 36.66833 lon: 116.99722 hasResults: False
nctId: NCT06365021 id: 88887.687583/2022-00 briefTitle: ACT for Syndromic and Subsyndromic Depression in Bipolar Disorder overallStatus: RECRUITING date: 2024-05 date: 2025-08 date: 2026-08 date: 2024-04-15 date: 2024-04-15 name: Beny Lafer class: OTHER briefSummary: The goal of this clinical trial is to test the efficacy of Acceptance and Commitment Therapy (ACT) as a psychotherapeutic treatment for patients with Bipolar Disorder (BD). The following questions will be investigated:
Scales and assessments will be used to measure study outcomes on 3 different time-points: pre-intervention (month 0), post-intervention (month 3) and follow-up (month 6). Mood scales will be assessed every 2 weeks for the duration of treatment and every 4 weeks during the additional 12 week follow-up period. Psychological Flexibility scale will be assessed every week for the duration of treatment; as well as brief mood diary, which will be assessed daily for the duration of treatment.
Results will be compared among both groups to assess the effectiveness of Acceptance and Commitment Therapy as an intervention for syndromic and sub-syndromic depression in bipolar disorder. conditions: Bipolar Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 42 type: ESTIMATED name: Acceptance and Commitment Therapy name: Bipolar Disorder Psychoeducation Therapy measure: Montgomery-Asberg Depression Scale measure: Young Mania Rating Scale measure: Functional Assessment Staging Tool measure: World Health Organization Quality of Life Brief Scale measure: Pittsburgh Sleep Quality Index measure: Psychological Flexibility Questionnaire measure: Generalized Anxiety Disorder 7-item Scale measure: Medication Recommendation Tracking Form measure: Regulatory Satisfaction Alertness Timing Efficiency Duration measure: Adhesion and Satisfaction Questionnaire measure: Life Events Scale sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tatiana Cohab Khafif status: RECRUITING city: São Paulo state: SP zip: 01231010 country: Brazil name: Tatiana Khafif, Master's degree role: CONTACT phone: +5511983389643 email: taticohab@gmail.com lat: -23.5475 lon: -46.63611 hasResults: False
nctId: NCT06365008 id: SYSKY-2024-210-01 briefTitle: Sintilimab Plus FOLFIRI as Salvage Therapy for Patients With Advanced Gastric Cancer overallStatus: RECRUITING date: 2024-04-08 date: 2027-04-08 date: 2027-09-30 date: 2024-04-15 date: 2024-04-15 name: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University class: OTHER briefSummary: The combination of immune checkpoint inhibitors and platinum containing dual drugs are more used as a first-line therapeutic approach for patients diagnosed with advanced gastric cancer for its superior efficacy. However, there are no standard recommendations for subsequent treatment after progression on first-line therapy. Here, the investigators conduct this open-label, monocenter, single arm phase II study to evaluate whether sintilimab in combination with irinotecan, leucovorin folinate and fluorouracil can be the salvage therapy for patients diagnosed with unresectable or metastatic gastric cancer progression on first-line therapy. Patients participated in this study will receive sintilimab 3mg/kg for patients with body weight\<60kg or 200mg for patients with body weight ≥ 60kg, plus irinotecan 180mg/m2 intravenous infusion, leucovorin folinate 400mg/m2 intravenous infusion and fluorouracil 400mg/m2 intravenous injection followed by 2400mg/m2 intravenous infusion for 48 hours, repeated every two weeks. The primary endpoint is progression-free survival (PFS). The investigators estimated that 40 patients were necessary. Secondary endpoints include overall survival, objective response rate, disease control rate and safety for unresectable or metastatic gastric cancer. conditions: Unresectable/Metastatic Gastric Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Patients will receive sintilimab 3mg/kg for patients with body weight\<60kg or 200mg for patients with body weight ≥ 60kg, plus irinotecan 180mg/m2 intravenous infusion, leucovorin folinate 400mg/m2 intravenous infusion and fluorouracil 400mg/m2 intravenous injection followed by 2400mg/m2 intravenous infusion for 48 hours, repeated every two weeks. primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: Sintilimab+irinotecan+leucovorin folinate+fluorouracil measure: Progression-free survival measure: Overall survival measure: Objective response rate measure: Disease control rate measure: Adverse Events sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sun Yat-sen Memorial Hospital,Sun Yat-sen University status: RECRUITING city: Guangzhou state: Guangdong zip: 510000 country: China name: Qiong Yang, Doctor role: CONTACT phone: 13632341201 email: yangqiong05@126.com name: Yajing Liu, Doctor role: CONTACT phone: 13631327315 email: liuyajing1030@126.com lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06364995 id: JKEUPM-2023-1364 briefTitle: Effects of Specialised Physical Education in Volleyball on Middle School Students' Physical Fitness and Performance overallStatus: RECRUITING date: 2024-01-10 date: 2024-06-28 date: 2024-07-05 date: 2024-04-15 date: 2024-04-16 name: Universiti Putra Malaysia class: OTHER briefSummary: Physical education stands as a collaborative, bilateral activity essential for the development and improvement of young people's physical qualities and plays a pivotal role in youth sports promotion. Volleyball offers a blend of aerobic and anaerobic exercises, developing muscle strength, bone density, cardiovascular health, and fine-tuning the nervous system. It is effective in improving physical attributes such as strength, speed, agility, endurance, and coordination, which are crucial for holistic student development and success in the standardized PE entrance examinations for senior high school.
Therefore, this study chose volleyball specialised physical education as an intervention to study the effect of physical fitness and The PE entrance examination for senior high school performance of middle school students. conditions: Physical Fitness conditions: Performance studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: In this experiment, the experimental group used the intervention of specialised physical education teaching of volleyball. However, the control group only conducted traditional physical education teaching content primaryPurpose: BASIC_SCIENCE masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: Volleyball name: Traditional Physical Education measure: Effects of physical fitness of middle school students measure: Effects on middle school students' PE entrance examination for senior high school test performance sex: ALL minimumAge: 13 Years maximumAge: 15 Years stdAges: CHILD facility: Yimou MAO status: RECRUITING city: Chengdu state: Sichuan zip: 610044 country: China name: Yimou MAO, PHD role: CONTACT email: 912327111@qq.com lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06364982 id: PER-ECL-2023-05 briefTitle: Distance Between Dental Implants as a Risk Indicator for Peri-implant Disease. overallStatus: NOT_YET_RECRUITING date: 2024-04-05 date: 2024-12-31 date: 2024-12-31 date: 2024-04-15 date: 2024-04-15 name: Universitat Internacional de Catalunya class: OTHER briefSummary: The aim of this study is to analyse contiguous dental implants and its peri-implant status depending on different inter-implant distances. conditions: Peri-implant Mucositis conditions: Peri-Implantitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 180 type: ESTIMATED name: Two contiguous dental implants placed with less ≤ 3mm from each other. name: Two contiguous dental implants placed with > 3mm from each other. measure: Prevalence of peri-implant diseases. measure: FMPI measure: FMBI measure: mPI measure: mBI measure: SoP measure: PPD measure: MR measure: KM measure: Implant location measure: Implant position measure: Implant type measure: Implant brand measure: Implant roughness measure: Implant diameter measure: Implant length measure: Apico-coronal position of the implant measure: Inter-implant distances (IID) measure: Implant placement protocol measure: Bone grafting procedures (BGP) at implant placement measure: Implant-supported restorations measure: Cleansability of the prosthesis sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clínica Universitaria de Odontologia city: Sant Cugat Del Vallès state: Barcelona zip: 08195 country: Spain lat: 41.47063 lon: 2.08611 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2024-04-10 uploadDate: 2024-04-10T16:21 filename: Prot_SAP_000.pdf size: 82991 hasResults: False
nctId: NCT06364969 id: 2021-06-02 briefTitle: Investigation of the Pruritogens of Liver-related Diseases overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2025-08-01 date: 2025-08-01 date: 2024-04-15 date: 2024-04-16 name: Peking University class: OTHER briefSummary: This study hopes investigate the itch-inducing ability of different potential pruritogen candidates of cholestasis pruritus, especially the intrahepatic cholestasis of pregnancy (ICP). In this study, a combination of skin application and needle-free subcutaneous injection was used to investigate whether human endogenous molecules can cause itching. And a questionnaire is used to quantify the intensity of different candidates-induced itch. conditions: Cholestasis conditions: Intrahepatic Cholestasis of Pregnancy studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: CROSS_SECTIONAL count: 200 type: ESTIMATED measure: Itch intensity measure: Flare areas sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Peking University city: Beijing state: Beijing zip: 100000 country: China name: Guangyi Lan role: CONTACT phone: 13176881226 email: Guangyi_lan@stu.pku.edu.cn name: Yulong Li role: PRINCIPAL_INVESTIGATOR lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06364956 id: SYSKY-2024-124-02 briefTitle: Phase Ib/II Trail of Neoadjuvant of Tislelizumab Combined With Palbociclib in Patients With Platinum-refractory Bladder Urothelial Carcinoma overallStatus: RECRUITING date: 2024-05 date: 2025-06 date: 2026-06 date: 2024-04-15 date: 2024-04-15 name: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University class: OTHER briefSummary: In order to explore the safety and antitumor efficacy of different doses of CDK4/6 inhibitor Palbociclib in combination with the Tislelizumab in platinum-refractory cT2-4aN0M0 bladder urothelial carcinoma, a phase Ib/II study was conducted.