hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06384040 id: GR-2019-12370692 briefTitle: Immuno-based Profiling of knEe OA Patients to Predict reSponse to Regenerative Treatment acronym: IMPRESA overallStatus: RECRUITING date: 2021-11-01 date: 2023-09-04 date: 2024-10-30 date: 2024-04-25 date: 2024-04-25 name: Istituto Clinico Humanitas class: OTHER name: Istituto Ortopedico Rizzoli briefSummary: Osteoarthritis (OA) is a highly prevalent degenerative musculoskeletal disease and a major cause of chronic disability worldwide. Its multifactorial origin contributes to determine the heterogeneous phenotypes and one unmet need is the lack of biomarkers to predict the individual response. Platelet-rich-plasma (PRP) injection is a minimally invasive autologous blood-derived approach for which we plan to define specific knee profiles predictive of response. We will take advantage of a unique multidisciplinary approach aimed at analysing clinics, imaging, and biomarkers of associated with clinical response. We will focus on inflammatory (Wnt system, IL1 pathway, PTX3) and antioxidant (primarily, DPP3/Keap1/Nrf2) pathways. We foresee that our results will allow a better allocation of immunomodulatory and regenerative therapies for a personalized approach in knee OA thus maximising the effectiveness of the healthcare allocation. conditions: Osteoarthritis, Knee studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 105 type: ESTIMATED name: platelet-rich plasma knee injection measure: knee OA patients focusing on changes in Wnt and IL1-ß signalling and PTX3 expression measure: To assess the overall oxidative status and antioxidant capacity of the enrolled OA patients and its possible prognostic role with respect to response to PRP treatment sex: ALL minimumAge: 40 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istituto Clinico Humanitas status: RECRUITING city: Rozzano state: Milano zip: 20089 country: Italy name: Berardo Di Matteo role: CONTACT phone: 02 82241 email: reumatologia@humanitas.it lat: 45.38193 lon: 9.1559 hasResults: False
nctId: NCT06384027 id: VNI_USG_2024 briefTitle: Effects of Non-invasive Ventilation on Function Diaphragmatic and Caval Distension overallStatus: RECRUITING date: 2024-02-05 date: 2024-04-17 date: 2024-06-10 date: 2024-04-25 date: 2024-04-25 name: Federal University of Paraíba class: OTHER briefSummary: Introduction: Understanding how the applicability of non-invasive ventilation can directly affect the anatomy and diaphragmatic function, as well as the opening diameter of the inferior vena cava in healthy individuals is fundamental to knowing how this therapy can interfere with treatment results. Objective: Identify the acute effects of PEEP and ventilatory support pressure on thickening fraction, diaphragmatic mobility and vena cava distension in healthy people. Methods: This is a crossover, randomized study, blinded to the evaluator and the researcher responsible for the statistical analysis. Volunteers will undergo a NIV session, randomized into groups: CPAP, Bi-level and spontaneous breathing, without NIV support (control). The outcomes evaluated will be diaphragmatic ultrasound and inferior vena cava distensibility. The CPAP levels will be: 5, 10 and 15 cmH2O after 5 minutes of use and in the Bi-level group we will maintain the PEEP value at 5cmH2O and modify the pressure support values to the values: 5, 7 and 10 cmH2O pressure support, with all outcomes also being assessed after 5 minutes. Participants will remain in a supine position, with the right upper limb positioned behind the head, throughout the protocol and all measurements will be collected in the inspiratory and expiratory phases with volumes basal currents. For statistical analysis, intention-to-treat analysis will be employed and groups will be compared using Student's t-test, for continuous variables, or chi-square, for categorical variables. ANOVA split-plot, repeated measures for primary occurrences. Analyzes of covariance to identify differences between groups using baseline scores as covariates. Effect sizes and confidence intervals will be calculated using eta squared (η²). Expected results: Elucidate the effects of different blood pressure levels on diaphragmatic function and inferior vena cava distension. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: This is a crossover, randomized study, blinded primaryPurpose: OTHER masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 100 type: ESTIMATED name: Non-invasive ventilation measure: Diaphragmatic thickening fraction measure: Diaphragmatic mobility measure: Ultrasound of inferior vena cava distension sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Federal University of Paraiba status: RECRUITING city: João Pessoa state: Paraiba zip: 58051-900 country: Brazil name: Eduardo França, PhD role: CONTACT phone: 5583996575859 lat: -7.115 lon: -34.86306 hasResults: False
nctId: NCT06384014 id: 2024/56 briefTitle: Examining the Effect of Different Filling Techniques on Healing in Lesional Teeth overallStatus: RECRUITING date: 2024-01-01 date: 2024-08-01 date: 2026-01-01 date: 2024-04-25 date: 2024-04-25 name: TC Erciyes University class: OTHER briefSummary: Microorganisms are an important factor in the development of periradicular diseases. The goal of non-surgical endodontic treatment is to eliminate microorganisms and their byproducts from the root canal system and to create an effective barrier between the root canal system and surrounding tissues. If there is no healing in the periradicular tissues after non-surgical endodontic treatment or if retreatment becomes impossible, surgical endodontic treatment is required. Apical resection is a surgical technique that involves removing the root tip of the tooth and closing the apical portion of the root canal system. An ideal retrograde filling material should be non-toxic, non-carcinogenic and biocompatible. It must also have dimensional stability and sealing properties. Amalgam, glass ionomer cements, and zinc oxide-eugenol based materials have been used for root end fillings in periapical surgery, but the desired success was not achieved. Today, Mineral Trioxide Aggregate (MTA) is preferred as a retrograde filling material due to its superior sealing properties, ability to harden in the presence of blood and moisture, antibacterial effects, biocompatibility and radiopacity.
In the researchers' study, the effect of apical resection after orthograde canal filling and retrograde canal filling during apical resection on postoperative recovery will be compared. In both canal filling techniques, Sure-Seal Root MTA (Sure Dent Corporation-Korea) will be used as the filling material. Sure-Seal Root MTA is a calcium silicate based paste that is typically pre-mixed and ready to apply, exhibits excellent physical properties and does not show shrinkage during the curing process. As the manufacturer states, it is hydrophilic, biocompatible, has ideal setting and working time.
Our faculty has piezosurgical ultrasonics (Mectron ®, Grassobbio BG, Italy). After the root tip resection is performed, the retrograde cavity will be prepared with Woodpecker ultrasonic tips (Guilin, China) compatible with this device. In our study using these materials and devices, a comparative analysis of the effects of different canal filling techniques on lesion healing and improvement in clinical symptoms will be made. conditions: Apical Cyst studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: İki farklı grupta farklı kanal dolum teknikleri uygulandıktan sonra apikal rezeksiyon yapılarak lezyon iyileşmesinin değerlendirilmesi primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: retrograde and orthograde root canal filling measure: Comparison of lesion healing rate after apical resection using different root canal filling techniques sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Erciyes Üniversitesi Diş Hekimliği Fakültesi status: RECRUITING city: Kayseri zip: 38039 country: Turkey name: ERASLAN AKYÜZ role: CONTACT phone: 4447138 phoneExt: 0352 email: ipekemamak@hotmail.com lat: 38.73222 lon: 35.48528 hasResults: False
nctId: NCT06384001 id: STUDY00004032 briefTitle: Meditation for Older Adults With Chronic Low Back Pain overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-10 date: 2025-12 date: 2024-04-25 date: 2024-04-25 name: Florida State University class: OTHER briefSummary: This pilot randomized controlled trial aims to recruit 66 community-dwelling older adults with chronic low back pain and follow up them for 8 weeks. This study aims to test the preliminary effect of a mindfulness-based meditation (MBM) intervention on pain and symptoms among community-dwelling older adults with chronic low back pain, and also to test the effect of the MBM intervention on the host Gut-Brain Axis (GBA). conditions: Chronic Low Back Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 66 type: ESTIMATED name: Active MBM name: Sham MBM measure: Change in pain intensity and interference measure: Change in pain sensitivities measure: Change in pain modulation measure: Change in chronic pain self-efficacy measure: Change in anxiety measure: Change in cognitive complaints measure: Change in depression measure: Change in fatigue measure: Change in sleep disturbance measure: Change in pain-related cortical response measure: Measurement and comparison of fecal microbiota alpha diversity, beta diversity, and abundance of microbial taxa in the human gut measure: Chang in inflammatory cytokines sex: ALL minimumAge: 50 Years maximumAge: 89 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06383975 id: CIV-24-01-045634 briefTitle: VEin of MArshall Ethanolization vs Extended Pulmonary Vein PULSEd Field Ablation After Failed PVI for Persistent AF acronym: VEMAPULSE overallStatus: NOT_YET_RECRUITING date: 2024-04-29 date: 2027-04-30 date: 2027-04-30 date: 2024-04-25 date: 2024-04-25 name: Sebastien Knecht class: OTHER name: Boston Scientific Corporation briefSummary: The goal of this clinical trial is to compare two ablation techniques to treat patients with persistent atrial fibrillation (irregular and often very rapid heart rhythm). An ablation is a procedure during which some scars are made on the inside of the heart to break up the electrical signals that cause the irregular heartbeat. In this trial researchers will compare a new technique, which uses tiny electric shocks to make the scars, to the standard technique, which uses heat.
* Complete a questionnaire 3, 6, 9 and 12 months after the procedure conditions: Persistent Atrial Fibrillation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 100 type: ESTIMATED name: Pulsed field ablation with posterior wall isolation name: Radiofrequency ablation and vein of Marshall ethanolization measure: Atrial tachyarrhythmia recurrence within 12 months measure: Safety and procedural related adverse event measure: Duration of the ablation procedure measure: Fluoroscopy time measure: Fluoroscopy dose measure: Effect of the procedure on quality of life measure: Incidence of repeat ablation measure: Unscheduled visits and hospitalization sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: AZ Sint-Jan Brugge AV city: Brugge zip: 8000 country: Belgium name: Emma Christiaen role: CONTACT email: emma.christiaen@azsintjan.be name: Sébastien Knecht, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 51.20892 lon: 3.22424 hasResults: False
nctId: NCT06383962 id: CP 21-001-UK02 briefTitle: Post-Market Data Collection to Evaluate the Performance of the Synergy Disc® overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2029-09-01 date: 2034-09-01 date: 2024-04-25 date: 2024-04-25 name: Synergy Spine Solutions class: INDUSTRY name: MCRA briefSummary: This is a real world data collection observational study at a single site. There are both prospective and retrospective cohorts. The study will examine the safety and effectiveness of the Synergy cervical disc system in patients with degenerative cervical disc disease. conditions: Cervical Degenerative Disc Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: Synergy cervical spine disc replacement measure: Neck Disability Index (NDI) measure: Device Related or Device Procedure Related Adverse Events measure: Neck and Arm Pain Measurement measure: Patient Satisfaction measure: Motor and Sensory Function in the Arm measure: Nurick's Criteria measure: Odom's criteria sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Royal Orthopaedic Hospital city: Birmingham country: United Kingdom name: Sam Papadopoullos role: CONTACT email: sam.papadopoullos@nhs.net name: Timothy Knight, MD role: PRINCIPAL_INVESTIGATOR name: Shahnawaz Haleem, MD role: SUB_INVESTIGATOR lat: 52.48142 lon: -1.89983 hasResults: False
nctId: NCT06383949 id: CP 21-001-IRE01 briefTitle: Real World Data Collection on the Synergy Disc overallStatus: RECRUITING date: 2024-02-23 date: 2028-02-23 date: 2033-02-23 date: 2024-04-25 date: 2024-04-25 name: Synergy Spine Solutions class: INDUSTRY name: MCRA briefSummary: This is a real world data collection observational study at a single site. There are both prospective and retrospective cohorts. The study will examine the safety and effectiveness of the Synergy cervical disc system in patients with degenerative cervical disc disease. conditions: Cervical Degenerative Disc Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: Synergy Cervical Disc system measure: Neck Disability Index (NDI) measure: Device Related or Device Procedure Related Adverse Events measure: Neck and Arm Pain Measurement measure: Patient Satisfaction measure: Motor and Sensory Function in the Arm measure: Nurick's Criteria measure: Odom's criteria sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mater Misericordiae University Hospital status: RECRUITING city: Dublin country: Ireland name: Jake McDonnell, MD role: CONTACT email: jackmcdonnell@rcsi.ie name: Joseph Butler, MD role: PRINCIPAL_INVESTIGATOR name: Stacy Darwish, MD role: SUB_INVESTIGATOR lat: 53.33306 lon: -6.24889 hasResults: False
nctId: NCT06383936 id: FAST-K II briefTitle: FAldini Sport Total Joint Arthroplasty-Knee II acronym: FAST-K II overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2025-12-31 date: 2025-12-31 date: 2024-04-25 date: 2024-04-25 name: Istituto Ortopedico Rizzoli class: OTHER briefSummary: The majority of patients undergoing total knee arthroplasty are elderly individuals with low functional demands, aiming to alleviate pain. However, there exists a subgroup of younger patients, under the age of 65, with higher functional demands. The purpose of this study is to evaluate the return to sports activities in this patient group following a non-cemented total knee arthroplasty procedure and a specific rehabilitation protocol. The investigators expect that with the use of non-cemented prostheses and a specific rehabilitation protocol, many of these patients will safely resume sports activities. conditions: Knee Osteoarthritis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: intensive rehabilitation after uncemented TKA measure: number of patients returning to sports activities assessed by questionnaire measure: clinical and functional outcomes measured as the variation in the Knee Society Score sex: ALL minimumAge: 40 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06383923 id: BYSYDL2022015 briefTitle: Risk Factors, Prognosis and Prediction Models for Placenta Accreta Without Prior Cesarean Section overallStatus: RECRUITING date: 2023-01-01 date: 2024-12 date: 2024-12 date: 2024-04-25 date: 2024-04-25 name: Peking University Third Hospital class: OTHER briefSummary: 1. Identify the risk factors for Placenta accreta spectrum (PAS) disorders in women without prior caesarean section (CS).
3. Use the cohort's biological sample database to conduct serology, cytology, and histology studies to explore the abnormal uterine immune microenvironment and the impact on uterine spiral artery remodeling in non-scar uterine-placenta accreta disease. conditions: Placenta Accreta Spectrum studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: Placenta Accreta Spectrum measure: Amount of bleeding measure: Hemostatic measures measure: hysterectomy measure: blood transfusion volume sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Peking University Third Hospital status: RECRUITING city: Beijing country: China name: Wang Yan, M.D.Ph.D. role: CONTACT phone: 13501282029 email: wjgqhn@263.net lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06383910 id: 10.185.1.58 briefTitle: The Effect Of Square Stepping Exercise Training On Cognitive Functions And Quality Of Life In Geriatric Individuals overallStatus: COMPLETED date: 2021-10-12 date: 2023-12-27 date: 2024-01-05 date: 2024-04-25 date: 2024-04-25 name: Pamukkale University class: OTHER briefSummary: This study was designed to investigate the effects of Square-Stepping Exercise Training on cognitive functions and quality of life in geriatric individuals. The volunteer participants in the study were randomly divided into two groups: a square-stepping exercise group and a control group.
The investigators used several assessment tools including Hodkinson's Mental Test, Montreal Cognitive Assessment, Stroop Test, Trail Making Test, and the Turkish World Health Organization Quality-of-Life Scale. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 56 type: ACTUAL name: Square Stepping Exercise measure: Change on Cognitive Functions from Base on the Montreal Cognitive Assessment In 6 Weeks measure: Change on Cognitive Functions from Base on the Stroop Test In 6 Weeks measure: Change on Cognitive Functions from Base on the Trail Making Test In 6 Weeks measure: Change on Quality of Live from Base on the World Health Organization Quality-of-Life Scale Turkish version In 6 Weeks sex: ALL minimumAge: 65 Years maximumAge: 75 Years stdAges: OLDER_ADULT facility: Pamukkale University city: Denizli country: Turkey lat: 37.77417 lon: 29.0875 hasResults: False
nctId: NCT06383897 id: HS-10398-101 briefTitle: Phase 1 Study in Healthy Participants and Participants With Kidney Dysfunction overallStatus: NOT_YET_RECRUITING date: 2024-05-31 date: 2025-01-31 date: 2025-01-31 date: 2024-04-25 date: 2024-04-25 name: Jiangsu Hansoh Pharmaceutical Co., Ltd. class: INDUSTRY briefSummary: A randomized, double-blind, placebo-controlled, dose-escalation clinical trial to evaluate the safety, tolerability, pharmacokinetic characteristics, and the impact of food on pharmacokinetics of oral HS-10398 in Chinese healthy participants, and a clinical trial to assess the pharmacokinetic characteristics of oral HS-10398 in Chinese participants with kidney dysfunction conditions: Healthy studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 116 type: ESTIMATED name: HS-10398 name: HS-10398 Placebo measure: Incidence and severity of adverse events (AEs) measure: Serious adverse events (SAEs) measure: Observed maximum plasma concentration (Cmax) measure: Time to reach maximum plasma concentration (Tmax) measure: Elimination Halflife (T1/2) measure: Apparent clearance（CL/F） measure: Apparent Volume of Distribution（Vd/F） sex: ALL minimumAge: 18 Years maximumAge: 64 Years stdAges: ADULT facility: The Affiliated Hospital of Qingdao University city: Qingdao country: China name: Xiaolei Zhang role: CONTACT phone: 0532-82912611 email: qingyilunli@126.com lat: 36.06488 lon: 120.38042 hasResults: False
nctId: NCT06383884 id: 2024-02-134 briefTitle: Patritumab Deruxtecan in Patients With Solid Tumor Harboring an NRG1 Fusion overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2027-04-30 date: 2029-04-30 date: 2024-04-25 date: 2024-04-25 name: Samsung Medical Center class: OTHER briefSummary: The NRG1 gene is located on chromosome 8 (8p12 region) and encode NRG1. NRG1 gene is translated to generate six different proteins (I-VI) and at least 31 isoforms. NRG1 proteins are structurally related to EGF and contain an EGF-like motif that binds and activates ErbB3 and ErbB4. Upon ligand binding, these receptors form homodimers or heterodimers, which results in phosphorylation of the intrinsic kinase domain, and activation of the PI3K-AKT, MAPK, and other pathways.
The overall incidence of NRG1 fusions is very rare. In many tumor types, only limited numbers of NRG1 fusion variant have been identified. By percentage, there is no organ dominance of the presence of NRG1 fusions. In an analysis of 21, 858 tumor specimens that underwent anchored multiplex PCR for targeted RNA sequencing, the prevalence of NRG1 fusions was 0.2%. Of these, CD74 was the most common partner (29%), followed by ATP1B1 (10%), SDC4 (7%), and RBPMS (5%), and most CD74-NRG1 fusions have been reported in patients with lung IMA. NRG1 fusions result in aberrant expression of the epidermal growth factor (EGF)-like domain of neuregulin-1 (NRG1) on the cell surface binds primarily to ErbB3 and ErbB4, leading to heterodimerization or oligomerization with other ERBB family members. NRG1-mediated activation of ErbB3 promotes dimerization with EGFR, ErbB2, and ErbB4. These partners phosphorylate ErbB3, forming docking sites for SH2-domain proteins, leading to pathologic activation of multiple signal transduction pathways, including the phosphoinositide 3-kinase (PI3K) pathway. Subsequently, ErbB3 expression was noted at high levels, and the proteins were phosphorylated, in fusion-positive cases. Targeting ErbB3 signaling therefore represents a promising therapeutic approach for patients with NRG1 fusion-positive malignancies. conditions: Solid Tumor, Adult studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Patritumab Deruxtecan measure: Objective response rate(ORR) measure: Duration of response (DoR) measure: Progression-free survival(PFS) measure: Disease-control rate(DCR) measure: Best percentage change in the SoD of measurable tumors measure: Overall survival(OS) measure: Incidence of Adverse events (CTCAE v5.0) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Samsung Medical Center city: Seoul zip: 06351 country: Korea, Republic of name: Se-Hoon Lee, MD, PhD role: CONTACT phone: +82-10-4579-7640 email: sehoon.lee@samsung.com lat: 37.566 lon: 126.9784 hasResults: False