hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06261970 id: 999002684 briefTitle: Increase First-time Mothers' Use of Postpartum Family Planning in Tanzania: The Connect Project acronym: Connect TZ overallStatus: ACTIVE_NOT_RECRUITING date: 2023-02-22 date: 2024-12 date: 2025-12 date: 2024-02-15 date: 2024-02-20 name: George Washington University class: OTHER name: Save the Children name: Save the Children International Tanzania name: Bill and Melinda Gates Foundation briefSummary: While a growing body of programs have shown promise to increase use of contraception among first time mothers (FTMs), difficulties remain in scaling beyond small pilot areas and institutionalizing within existing systems. Connect's approach aims to strengthen existing government health systems and community-level health efforts, including those supported through local and international non-governmental organizations, by developing and testing light-touch "enhancements" with the goal of increasing postpartum Family Planning (PPFP) adoption among FTMs. The investigators will evaluate Connect's approach through a cluster randomized control trial. conditions: Contraceptive Usage studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 1134 type: ACTUAL name: Connect measure: Adoption of of Postpartum Family Planning (PPFP): measure: Currently Using PPFP measure: Adopted or Intention to adopt PPFP measure: Average Satisfaction with PPFP methods measure: Contraceptive Preferences measure: Quality of Family Planning Counseling measure: Communication and Agency measure: PPFP Attitudes measure: PPFP Knowledge sex: FEMALE minimumAge: 14 Years maximumAge: 25 Years stdAges: CHILD stdAges: ADULT facility: EDI city: Bahi state: Dodoma country: Tanzania lat: -5.98304 lon: 35.3159 facility: EDI city: Kongwa state: Dodoma country: Tanzania lat: -6.2 lon: 36.41667 hasResults: False
nctId: NCT06261944 id: NIRDM-SXCIP03 briefTitle: A Pivotal Clinical Investigation Confirming the Safety and Accuracy of the Glyconics-DS in Assessment of Glycated Nail Keratin in Individuals With Unknown Diabetes Status and Performance Evaluation of the Glyconics SW Package acronym: ANODE03 overallStatus: RECRUITING date: 2024-03-13 date: 2024-06-30 date: 2024-08-08 date: 2024-02-15 date: 2024-03-21 name: Glyconics Ltd class: INDUSTRY briefSummary: The main clinical study objective is to confirm the accuracy of the Glyconics-DS spectrometer when used in its intended medical purpose population, i.e., in individuals with unknown diabetes risk. Additionally, this investigation will serve as a pivotal performance evaluation for the associated software for correct delivery of the algorithm-based analysis of the individual diabetes risk. The study will be considered positive if the backend delivery of the chemometrics output is performed correctly as per the cloud-based analysis and its delivery represents the essential medical software to be evaluated in this investigation. The 'true' diabetes risk will be contrasted against values of an internal biomarker indicative of glycaemia, HbA1c, as measured based on standardised, certified methodology. conditions: Pre-diabetes conditions: Undiagnosed Diseases studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Mass-screening primaryPurpose: SCREENING masking: NONE count: 480 type: ESTIMATED name: Near-infrared (NIR) measure: Dichotomised diabetes risk status measure: Sensitivity and specificity sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sant Pau Hospital status: RECRUITING city: Barcelona country: Spain name: Didac Mauricio, MD, PhD role: CONTACT lat: 41.38879 lon: 2.15899 hasResults: False
nctId: NCT06261931 id: 6313 briefTitle: Severity Over Time of Early Forms of Spondyloarthritis acronym: STAR overallStatus: NOT_YET_RECRUITING date: 2024-02-12 date: 2026-02-28 date: 2044-02-28 date: 2024-02-15 date: 2024-02-15 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: Spondyloarthritis (SpA) is a group of chronic inflammatory pathologies whose progression over time is poorly defined, and in particular the clinical and instrumental elements that can predispose to a condition of disease severity are not completely known. It would be important to have an idea of what the predisposing factors are, possibly already at baseline, and possibly also at follow up, of severe disease, so as to be able to act early with more aggressive and targeted therapies on these patients, so as to achieve remission. conditions: Spondyloarthritis conditions: Spondyloarthritis, Axial studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 387 type: ESTIMATED name: Diagnostic assessment name: Diagnostic assessment measure: spondyloarthritis severity sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione Policlinico Universitario A. Gemelli IRCCS city: Roma zip: 00168 country: Italy name: Maria Antonietta D'Agostino role: CONTACT phone: +390630155701 email: mariaantonietta.dagostino@policlinicogemelli.it name: Maria Antonietta D'Agostino role: PRINCIPAL_INVESTIGATOR name: Augusta Ortolan role: SUB_INVESTIGATOR lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06261918 id: 6269 briefTitle: Transcriptional and Epimetabolic Profile of Breast Carcinoma With Luminal or HER2+ or Locally Advanced Triple-negative Histotype in Patients With/Without Previous Clinical History of Metabolic Syndrome acronym: PROMETA overallStatus: RECRUITING date: 2024-02-01 date: 2025-02-01 date: 2026-07-01 date: 2024-02-15 date: 2024-02-15 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: This prospective pilot study of biological specimens aims to identify new prognostic and predictive biomarkers of response to standard therapy for local advanced BC, as well as to identify new targets for the development of immuno- therapeutic protocols. First aim is therefore to expand our knowledge to increase the response to preoperative treatment, intensify treatment patterns, and select patients based on clinical parameters. In this regard, it appears imperative to investigate yet under-investigated factors that might impair the response to standard therapy for local advanced BC including association to metabolic syndrome and analysis of tumoral and stromal features supporting a tumor microenvironment impenetrable to both drugs and immune system cells. conditions: Breast Cancer conditions: Metabolic Syndrome studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 120 type: ESTIMATED name: Influence of metabolic syndrome on the achievement of pathological complete response measure: Acheivement of pathological complete response measure: Event-free survival (EFS) sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione Policlinico Universitario A. Gemelli - IRCCS status: RECRUITING city: Roma country: Italy name: Alessandra Fabi role: CONTACT phone: 0630153773 email: alessandra.fabi@policlinicogemelli.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06261905 id: 2000036908 id: 000 type: OTHER domain: CTGTY briefTitle: Vitamin D in OUD: Exploration of Alterations on the Dopamine D2/D3 Receptor System overallStatus: RECRUITING date: 2024-03-13 date: 2024-06 date: 2024-06 date: 2024-02-15 date: 2024-04-12 name: Yale University class: OTHER name: University of Pennsylvania briefSummary: The research team is investigating Opioid Use Disorder (OUD), a disorder characterized by dysregulated dopaminergic tone, to evaluate the mechanisms of adjunctive treatment with calcitriol. The investigators will recruit 12 subjects with OUD and 12 healthy subjects to participate in a double-blind, randomized study design where subjects will complete up to 2 Positron Emission Tomography (PET) scans using \[11C\]-PHNO. The investigators will compare subjects in differences between their own study days and in differences between healthy control subjects and subjects with OUD. conditions: Opioid Use Disorder studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: This is primarily a within-subject, two scan, randomized, double-blind, placebo-controlled study design. Healthy control subjects will only complete one scan to serve as a baseline comparison for subjects with OUD. primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 24 type: ESTIMATED name: [11C]-PHNO name: Calcitriol name: Placebo Control name: PET Scan measure: Non-displaceable Tracer Binding Potentials (BPND) measure: Non-displaceable Tracer Binding Potentials (BPND) measure: Spontaneous Blink Rate (SBR) measure: Continuous Performance Task - Identical Pairs (CPT-IP) measure: Probabilistic Reversal Learning Task (PRLT) sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Yale School of Medicine status: RECRUITING city: New Haven state: Connecticut zip: 06510 country: United States name: Marcella Mignosa role: CONTACT phone: 203-903-7795 email: marcella.mignosa@yale.edu name: Adam Stryjewski role: CONTACT phone: 203-535-4424 email: adam.stryjewski@yale.edu name: Marc Potenza, MD, PhD role: PRINCIPAL_INVESTIGATOR name: Gustavo Angarita, MD role: PRINCIPAL_INVESTIGATOR lat: 41.30815 lon: -72.92816 hasResults: False
nctId: NCT06261892 id: 2023-002 briefTitle: Non-invasive Biomarker Discovery for Pre-cervical or/and Cervical Cancer-HPV DNA and Other Biomarkers in Urine overallStatus: RECRUITING date: 2023-07-20 date: 2025-06 date: 2025-06 date: 2024-02-15 date: 2024-02-15 name: WomenX Biotech Limited class: INDUSTRY name: Hong Kong Science and Technology Parks Corporation briefSummary: The goal of this clinical trial is
If there is a comparison group: Researchers will compare The diseased group and the healthy group according to the medical reports they provided to see if HPV DNA from urine is a promising biomarker for the detection of pre-cervical or cervical cancer conditions: Cervical Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 300 type: ESTIMATED name: Collect HPV DNA from urine measure: HPV DNA from urine is a promising biomarkers for the detection of pre-cervical/ cervical cancer sex: FEMALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: WomenX Biotech Limited status: RECRUITING city: Hong Kong country: Hong Kong name: Alan LIU, Master role: CONTACT phone: +852 64786939 email: alanliu@womenx.net lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06261879 id: 2023-001 briefTitle: Non-invasive Biomarker Discovery for Pre-cervical or/and Cervical Cancer--ACTN4 and Other Biomarkers in Menstrual Blood overallStatus: RECRUITING date: 2023-07-20 date: 2025-06 date: 2025-06 date: 2024-02-15 date: 2024-02-15 name: WomenX Biotech Limited class: INDUSTRY briefSummary: The goal of this clinical trial is
If there is a comparison group: Researchers will compare The diseased group and the healthy group according to the medical reports they provided to see if ACTN4 from menstrual blood is a promising biomarker for the detection of pre-cervical or cervical cancer conditions: Cervical Cancer conditions: CIN studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 300 type: ESTIMATED name: Special sanitary pad measure: ACTN4 is a promising biomarkers for the detection of pre-cervical/ cervical cancer sex: FEMALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: WomenX Biotech Limited status: RECRUITING city: Hong Kong country: Hong Kong name: Alan LIU, Master role: CONTACT phone: +852 64786939 email: alanliu@womenx.net lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06261866 id: MultiInter-CCS briefTitle: Multimodality Imaging and Functional Lesion Assessment in Intermediate Coronary Stenosis in Chronic Coronary Syndrome acronym: MultiInter-CCS overallStatus: RECRUITING date: 2011-04-07 date: 2024-12-31 date: 2028-12-31 date: 2024-02-15 date: 2024-02-15 name: Medical University of Warsaw class: OTHER briefSummary: The aim of this prospective, investigator-initiated study is to evaluate the diagnostic accuracy and correlations between functional indices (fractional flow reserve, FFR) and morphometric indices: luminal and qualitative parameters assessed by optical coherence tomography (OCT) including minimal lumen area, plaque type, presence of thin cap fibroatheroma among patients with chronic coronary syndrome identified with intermediate grade coronary stenosis. conditions: Chronic Coronary Syndrome studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: Correlation between fractional flow reserve (FFR) and minimal lumen area within the coronary stenosis measure: Correlation between fractional flow reserve (FFR) and mean lumen area within the coronary stenosis measure: Major adverse cardiovascular events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Medical University of Warsaw status: RECRUITING city: Warsaw country: Poland name: Mariusz Tomaniak, MD, PhD, Assoc. Prof. role: CONTACT email: mariusz.tomaniak@wum.edu.pl name: Piotr Baruś, MD role: CONTACT email: piotr.barus@wum.edu.pl lat: 52.22977 lon: 21.01178 hasResults: False
nctId: NCT06261853 id: 2-081-23 briefTitle: The Impact of 3D-CBCT Imaging on Nerve Injuries During Wisdom Tooth Surgery acronym: IMPACTION overallStatus: NOT_YET_RECRUITING date: 2024-02 date: 2025-05 date: 2025-05 date: 2024-02-15 date: 2024-02-28 name: University of Aberdeen class: OTHER name: Zarqa University name: King's College London briefSummary: The investigators aim to investigate if the additional information available from a 3D scan of the wisdom tooth can reduce the risk of nerve injury during wisdom tooth surgery compared to conventional 2D images.
The risk of nerve injury during wisdom tooth surgery is assessed using X-ray images, which show the position of the nerve and tooth in the jawbone. 2D and 3D scans are used, which have their own advantages and disadvantages such as reduced cost and radiation dose with 2D or more information from 3D images, but it remains unclear which is better at reducing the risk of nerve injuries. conditions: Inferior Alveolar Nerve Injuries conditions: Impacted Third Molar Tooth studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Pragmatic, two-arm, single-blinded, randomised controlled trial designed to investigate the differences between 3D cone-beam computerised tomography (CBCT) and 2D orthopantomography (OPG) in reducing inferior alveolar nerve injuries during wisdom tooth surgery. primaryPurpose: PREVENTION masking: DOUBLE maskingDescription: Double (Participant, Outcomes Assessor) A single-blinded methodology will be employed due to the nature of the image-based investigation where the surgeon is required to utilise one imaging modality during the surgery. In order to eliminate any influence or bias on the outcomes and data obtained for the primary objective, both the subject (patient) and the study member who will do the follow-up call will be blinded to the imaging techniques used on the day of surgery. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 1292 type: ESTIMATED name: 3D-CBCT name: 2D-OPG measure: The number of patients reporting altered sensation in their lip and/or chin on the side of wisdom tooth surgery measure: Surgical time measure: Planned surgical approach measure: Intraoperative complications measure: Postoperative Complications measure: Wisdom tooth impaction classification sex: ALL minimumAge: 16 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: King'S College Hospital Nhs Foundation Trust city: London state: England zip: SE5 9RS country: United Kingdom name: Nadine Khawaja, BDS PhD role: CONTACT email: nadine.khawaja@kcl.ac.uk name: Nadine Khawaja role: PRINCIPAL_INVESTIGATOR lat: 51.50853 lon: -0.12574 facility: Aberdeen Dental Hospital city: Aberdeen state: Scotland zip: AB25 2ZR country: United Kingdom name: Anand Lalli, BDS PhD role: CONTACT phone: 01224553515 email: anand.lalli@nhs.scot name: Rahmeh Alhyari, BDS role: CONTACT email: r.alhyari.22@abdn.ac.uk name: Anand Lalli, Consultant in Oral Surgery role: PRINCIPAL_INVESTIGATOR lat: 57.14369 lon: -2.09814 hasResults: False
nctId: NCT06261840 id: 2024-101 briefTitle: Refining Treatment Options for Trichomonas Vaginalis Infection: A Comparative Analysis of Metronidazole and Secnidazole overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2029-05-01 date: 2029-07-31 date: 2024-02-15 date: 2024-02-15 name: Tulane University class: OTHER name: University of Alabama at Birmingham name: Louisiana State University Health Sciences Center in New Orleans briefSummary: This is a multi-centered, randomized, open-label, parallel, phase IV clinical trial comparing the effectiveness and cost-effectiveness of oral multi-dose metronidazole (MTZ) and oral single-dose secnidazole (SEC) for the treatment of Trichomonas vaginalis in both women and men. conditions: Trichomonas Vaginitis studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 1200 type: ESTIMATED name: Metronidazole 500 mg name: Secnidazole 2000 MG measure: Treatment, as Measured by the Number of Participants that are Cured of Trichomonas Vaginalis sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06261814 id: iRISID-2023-2142 briefTitle: Contrast Enhanced Ultrasound to Evaluate Response to Chemoembolization in Patients With Liver Tumors overallStatus: NOT_YET_RECRUITING date: 2024-08-31 date: 2027-07-01 date: 2028-01-01 date: 2024-02-15 date: 2024-04-01 name: john eisenbrey class: OTHER briefSummary: This phase II trial evaluates the diagnostic performance of contrast-enhanced ultrasound (CEUS) for assessing treatment response in patients undergoing transarterial chemoembolization (TACE) for liver tumors. TACE is a hepatic artery embolization technique involving the injection of a blocking agent and a chemotherapy agent to treat liver cancers. Currently, contrast enhanced magnetic resonance imaging or computed tomography are used to assess disease response 1-2 months after TACE treatment, but ultrasound may be a less expensive, earlier alternative. CEUS is an imaging procedure that uses high-frequency sound waves to generate images of the body after administering lumason, an imaging agent used to enhance visualization of blood flow on ultrasounds. CEUS is able to be performed during the TACE procedure, making it possible to evaluate treatment response earlier than standard techniques. CEUS may be an effective method to evaluate treatment response more accurately and much earlier than current standard evaluation methods. conditions: Liver Neoplasms studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: No Data Available primaryPurpose: DIAGNOSTIC masking: NONE count: 266 type: ESTIMATED name: Sulfur Hexafluoride Lipid Microspheres name: Contrast-Enhanced Ultrasound name: Transarterial Chemoembolization name: Medical Chart Review measure: Recurrence measure: Specificity measure: Positive predictive value measure: Negative predictive value measure: False discovery rate measure: Residual tumor vacularity measure: Diagnostic performance for each imaging mode measure: Ability of the model to predict binary treatment response sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sidney Kimmel Cancer Center at Thomas Jefferson University city: Philadelphia state: Pennsylvania zip: 19107 country: United States lat: 39.95233 lon: -75.16379 hasResults: False
nctId: NCT06261801 id: GZY-ZJ-KJ-23088 briefTitle: Efficacy of Electroacupuncture Combined With Pregabalin in the Treatment of Trigeminal Herpetic Neuralgia: a Multicenter Randomized Controlled Trial Study Protocol overallStatus: RECRUITING date: 2024-02-07 date: 2025-07-20 date: 2025-12-20 date: 2024-02-15 date: 2024-02-15 name: The Third People's Hospital of Hangzhou class: OTHER name: The Third Affiliated hospital of Zhejiang Chinese Medical University briefSummary: Trigeminal herpetic neuralgia is a common type of Zoster-associated Pain (ZAP), which troubles individuals in all ages and burdens society all over the world. Eleactroaupuncture (EA) is increasingly used in the treatment of ZAP due to its advantages such as low price, high safety, no adverse reactions, and high patient acceptance. Therefore, it is necessary to conduct randomized controlled trials to evaluate the effectiveness and safety of EA on ZAP and whether EA can be used as a substitute for pregabalin. conditions: Trigeminal Herpetic Neuralgia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 102 type: ESTIMATED name: Medication Group name: EA Group name: EA+Medication Group measure: Visual Analog Score change measure: McGill Pain Questionnaire Short Form (SF-MPQ) measure: Brief Pain Inventory Scale (BPI-SF) measure: Medical Outcomes Study Sleep Scale (MOS-SS) measure: Hamilton Depression Rating Scale (HAMD)Hamilton Anxiety Rating Scale (HAMA) measure: Hamilton Depression Rating Scale (HAMD) measure: Short Form 36 Health Survey (SF-36) sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Hangzhou Third People's Hospital status: RECRUITING city: Hangzhou state: Zhejiang zip: 310009 country: China name: Pin Lin role: CONTACT phone: 1358876268686 email: yjlp1@163.com name: Chengcheng Kong role: CONTACT phone: 8613868078286 lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06261788 id: EASY II Trial briefTitle: Efficacy and Safety of the Sync-AV II Temporary Cardiac Pacing Catheter overallStatus: COMPLETED date: 2023-06-01 date: 2023-09-13 date: 2023-09-26 date: 2024-02-15 date: 2024-02-15 name: Swift Sync, Inc. class: INDUSTRY name: Regulatory and Quality Solutions briefSummary: This is a prospective, single-center, non-randomized open label study. The objective of this study is to evaluate the efficacy and safety of the Sync-AV II Temporary Cardiac Pacing Catheter in subjects whose elective surgical or interventional procedure require temporary pacing support. conditions: Heart Block conditions: Valve Heart Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 30 type: ACTUAL name: Temporary pacing measure: With a commercially available pacing box and/or analyzer, measure the ventricular pacing threshold at 24 hours post implant of the investigational device (index procedure) measure: Procedure related complications sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centro de Intervenciones Endovasculares y Cirugia Cardiovascular city: Asunción country: Paraguay lat: -25.30066 lon: -57.63591 hasResults: False