hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06360289 id: ALN-TTR-NT-003 briefTitle: Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2027-04 date: 2024-04-11 date: 2024-04-11 name: Alnylam Pharmaceuticals class: INDUSTRY briefSummary: This is a single-center observational study evaluating the potential value of NfL as a biomarker for diagnosis, detection of disease onset, monitoring of disease progression, and treatment response in asymptomatic carriers of TTR variants and symptomatic hATTR amyloidosis patients with polyneuropathy. conditions: Hereditary Amyloidosis, Transthyretin-Related conditions: Asymptomatic Carrier State studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 500 type: ESTIMATED name: Standard of Care measure: NfL Levels in Asymptomatic Carriers of a TTR Variant and Symptomatic hATTR Patients With Polyneuropathy at Baseline measure: Change in NfL Levels Over Time in Asymptomatic Carriers of a TTR Variant and Symptomatic hATTR Patients With Polyneuropathy measure: Correlation Between the NfL Levels and Various Biological and Clinical Activity Parameters in Asymptomatic Carriers of a TTR Variant and Symptomatic hATTR Patients With Polyneuropathy at Baseline measure: Correlation Between the Change in NfL Levels and Various Biological and Clinical Activity Parameters in Asymptomatic Carriers of a TTR Variant and Symptomatic hATTR Patients With Polyneuropathy measure: Comparison of the Measured NfL Levels to the Normal Levels Expected to be Seen in the General Population by Using the Existing Reference Ranges and Databases measure: Time to Onset of Active Disease in Asymptomatic Carriers of TTR Variants measure: Disease Progression in Symptomatic hATTR Amyloidosis Patients with Polyneuropathy sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Centre Hospitalier Universitaire (CHU) Le Kremlin-Bicêtre Assistance Publique-Hôpitaux de Paris (APHP) city: Paris state: Île-de-France zip: 94270 country: France lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06360276 id: 14012021 briefTitle: Effect of Seated Exercises and Psychoeducational Rehabilitation on Fatigue and Coping of Women Postmastectomy overallStatus: COMPLETED date: 2022-03-14 date: 2022-08-02 date: 2022-08-12 date: 2024-04-11 date: 2024-04-11 name: Alexandria University class: OTHER briefSummary: This study aimed to examine the effect of bundling seated exercises and psychoeducational rehabilitation using the teach-back approach on fatigue and coping of women postmastectomy.
A quasi-experimental research was conducted in the main University Hospital, Alexandria, Egypt. A total of 60 women were randomly allocated to one of two groups.; women in the study group practiced seated exercises and psychological rehabilitation interventions, including mindfulness breathing, problem-solving training, cognitive reframing technique, and thought stopping. conditions: Fatigue conditions: Coping Behavior studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 60 type: ACTUAL name: Seated Exercises name: Psychoeducational Rehabilitation name: Routine Care measure: Piper Fatigue Scale measure: Mini-Mental Adjustment to Cancer Scale sex: FEMALE minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Faculty of Nursing city: Alexandria zip: 56321 country: Egypt lat: 31.21564 lon: 29.95527 hasResults: False
nctId: NCT06360263 id: #1-6/2023 briefTitle: OSSEODENSIFICATION BY DENSAH BURS WITH ACTIVATED PLASMA ALBUMIN GEL FOR SINUS LIFTING WITH SIMULTANEOUS IMPLANT PLACEMENT overallStatus: RECRUITING date: 2023-07-11 date: 2024-08 date: 2024-08 date: 2024-04-11 date: 2024-04-11 name: Esraa Salem Kamal class: OTHER briefSummary: Aim of the current study is to evaluate clinically and radiographically transcrestal sinus lifting with densah burs with the use of activated plasma albumin gel associated with simultaneous implant placement. conditions: Bone Loss, Alveolar studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 6 type: ESTIMATED name: Densah bur in combination with activated plasma albumin gel measure: Postoperative pain measure: Implant stability measure: Vertical bone height gain measure: Bone density around implant sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Faculty of Dentistry, Alexandria University status: RECRUITING city: Alexandria country: Egypt name: Esraa S Kamal, BDS role: CONTACT phone: 106 054 3345 phoneExt: +20 email: esraasalemkamal@gmail.com lat: 31.21564 lon: 29.95527 hasResults: False
nctId: NCT06360250 id: B2001-F20220601 briefTitle: Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of the Fully Human Anti-tetanus Toxin Monoclonal Antibody A82 / B86 Injection Combination Formulation overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-10-30 date: 2024-10-30 date: 2024-04-11 date: 2024-04-11 name: Changchun BCHT Biotechnology Co. class: INDUSTRY name: The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine name: Anning City First People's Hospital briefSummary: To evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of the full human anti-tetanus toxin monoclonal antibody A82 / B86 injection combination formulation conditions: Clostridium Tetanus studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 190 type: ESTIMATED name: Human anti-tetanus toxin monoclonal antibody A82 / B86 injection combination preparation name: Tetanus human immunoglobulin (HTIG) name: Whole-human anti-tetanus toxin monoclonal antibody A82 / B86 injection placebo name: Adsorbed tetanus vaccine (TT) measure: Safety evaluation index measure: PK evaluation index measure: PK evaluation index measure: PK evaluation index measure: PK evaluation index measure: PK evaluation index measure: PK evaluation index measure: PD evaluation index measure: PD evaluation index measure: PD evaluation index measure: Immunogenicity evaluation index sex: ALL minimumAge: 18 Years maximumAge: 59 Years stdAges: ADULT hasResults: False
nctId: NCT06360237 id: ISIS 678354 briefTitle: Olezarsen Early Access Program for Patients With Familial Chylomicronemia Syndrome (FCS) overallStatus: AVAILABLE date: 2024-04-11 date: 2024-04-11 name: Ionis Pharmaceuticals, Inc. class: INDUSTRY briefSummary: The purpose of the Expanded Access Program is to provide pre-approval access of olezarsen to eligible patients with Familial Chylomicronemia Syndrome (FCS). conditions: Familial Chylomicronemia Syndrome studyType: EXPANDED_ACCESS name: Olezarsen sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06360224 id: CASES briefTitle: Collect Flow and Ultrasound Images of Coronary Bypass Grafts acronym: CASES overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2029-05-15 date: 2029-05-15 date: 2024-04-11 date: 2024-04-11 name: Medistim ASA class: INDUSTRY briefSummary: This is a post-market observational, non-interventional, multicenter clinical investigation with the purpose of harvesting high quality data from regular cardiac bypass surgery (CABG). conditions: Cardiac Bypass Surgery (CABG) studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: MiraQ systems with Transit Time Flow Measurement (TTFM) and High Frequency Ultrasound (HFUS) probes measure: Wide and high-quality dataset uploaded to CaseCloud from CABG-procedures. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06360211 id: 22251 briefTitle: A Study to Learn About How BAY2927088 Affects the Level of Midazolam in the Blood When Both Drugs Are Taken Together in Healthy Participants overallStatus: RECRUITING date: 2024-04-17 date: 2024-06-11 date: 2024-06-11 date: 2024-04-11 date: 2024-04-22 name: Bayer class: INDUSTRY briefSummary: Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called Epidermal growth factor receptor (EGFR) and Human epidermal growth factor receptor 2 (HER2) mutations.
Period 1 (Day 1 to Day 2): On Day 1, participants will take midazolam Period 2 (Day 3 to Day 4): On Day 3, participants will take midazolam with BAY2927088 Period 3 (Day 5 to Day 15): On Days 5 to 13, participants will take BAY2927088 On Day 14, participants will take midazolam with BAY2927088
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatment. conditions: Advanced Non-small Cell Lung Cancer conditions: EGFR Mutation conditions: HER2 Mutation conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SEQUENTIAL primaryPurpose: OTHER masking: NONE count: 15 type: ESTIMATED name: BAY2927088 name: Midazolam measure: Cmax of midazolam when given with and without BAY2927088 measure: AUC of midazolam when given with and without BAY2927088 measure: Number of participants with TEAEs measure: Severity of TEAEs sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: PAREXEL International, Baltimore status: RECRUITING city: Baltimore state: Maryland zip: 21225 country: United States lat: 39.29038 lon: -76.61219 hasResults: False
nctId: NCT06360198 id: 2022-874/08 briefTitle: The Relationship Between Posture, Sense of Position, Musculoskeletal Discomfort and Anxiety overallStatus: COMPLETED date: 2022-06-30 date: 2022-11-30 date: 2022-12-30 date: 2024-04-11 date: 2024-04-11 name: Ankara Yildirim Beyazıt University class: OTHER briefSummary: It is known that posture is affected by various factors such as somatosensation, visual perception and cognition. In addition, it is also thought to affect conditions such as stress and anxiety through receptors. The aim of this study was to investigate the relationship between postural changes such as thoracic kyphosis, musculoskeletal problems, trunk position sense and anxiety in young individuals who were asymptomatic in terms of musculoskeletal problems. conditions: Kyphosis Postural Thoracic conditions: Proprioception conditions: Musculoskeletal System conditions: Anxiety studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 67 type: ACTUAL name: No intervention measure: Throcic Kyphosis measure: Trunk Position Sense measure: Musculoskeletal Discomfort measure: Anxiety sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ankara Yıldırım Beyazıt University city: Ankara country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06360185 id: Asthma V2 October 2023 briefTitle: Retrospective Study of Patients With Acute Presentation for Asthma to an Emergency Department in UK (RAPAE) acronym: RAPAE overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-01 date: 2025-12-01 date: 2024-04-11 date: 2024-04-11 name: Norfolk and Norwich University Hospitals NHS Foundation Trust class: OTHER briefSummary: Study team will obtain a list of all patients who have been seen in A+E over the past 6 years with a discharge diagnosis of asthma. Their history will be reviewed from their A+E notes. Team will obtain weight and height from Electronic prescribing tool and will obtain compliance information and past medical history from participant's GP records. Team will use participant's postcode to word out socio economic status quintile using office of national statistics tool. The following information will be taken from hospital documentation and from GP records. conditions: Asthma Acute studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 400 type: ESTIMATED measure: Change in body weight measure: Change in body height sex: ALL minimumAge: 16 Years maximumAge: 99 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06360172 id: 3-2024 briefTitle: The Feasibility of Motivational Interviewing on Emotional Authenticity, Dispositional Optimism, And Academic Motivation Among Nursing Students: A Randomized Controlled Trial overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-20 date: 2024-06-01 date: 2024-06-15 date: 2024-04-11 date: 2024-04-11 name: Alexandria University class: OTHER briefSummary: Motivational interviewing, or MI, is a collaborative, person-centered counseling technique to uncover and enhance a person\'s motivation for behavior change . MI was first created for the treatment of substance dependence, but it has since been successfully implemented in several fields, including healthcare and education (. Given the vital role that nursing students play in the healthcare system, Saudi Arabia, like many other nations, has realized how important it is to improve the motivation and well-being of its nursing students conditions: Nursing Students studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ACTUAL name: Motivational Interviewing measure: Kernis-Goldman Authenticity Inventory measure: The Life Orientation Test-Revised form for Adolescents measure: Academic Motivation Scale sex: MALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Nursing, Alexandria university city: Alexandria country: Egypt lat: 31.21564 lon: 29.95527 hasResults: False
nctId: NCT06360159 id: Massage on Newborns briefTitle: Massage for Newborns Receiving Nasal CPAP overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2026-05-15 date: 2026-05-15 date: 2024-04-11 date: 2024-04-15 name: Sultan Besiktas class: OTHER briefSummary: One of the most frequently required treatments for respiratory distress in neonatal intensive care is continuous positive airway pressure (NCPAP) support through the nose. NCPAP application has many advantages but also disadvantages and complications.
Gastric-abdominal distension, which is a complication of NCPAP application, is caused by gas entering the stomach and gastrointestinal tract. Feeding intolerance may develop in the newborn due to abdominal distension. In recent studies, it has been determined that non-pharmacological methods and supportive developmental care practices used to increase the comfort and reduce pain and stress of babies who experience painful procedures such as NCPAP application and who are exposed to the stressful neonatal intensive care unit environment are effective in increasing comfort and reducing pain and stress. These practices include therapeutic touch, mother's voice, fetal position, white noise, lullaby, wrapping and massage. In the literature, a quasi-experimental study examining the effect of massage (Field massage technique) on the respiration, heart rate and oxygen saturation of 28-34 week old newborns with respiratory distress syndrome who received nasal CPAP showed that massage had no significant effect on oxygen saturation, but respiration and heart rate decreased after the massage. has been determined. There are studies in the literature examining the effects of therapeutic touch, mother's voice, fetal position, white noise, lullaby and wrapping in order to increase the comfort of newborns receiving nasal CPAP, reduce stress and pain, and prolong sleep time. However, no research has been found in the literature examining the effects of massage on the stress, comfort and health parameters of newborns receiving nasal CPAP. conditions: Massage conditions: Stress conditions: Newborn conditions: Comfort studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Intervention group (Massage): Babies in the intervention group will be massaged three times a day for 3 days, each session lasting 15 minutes, in accordance with the field massage technique. Massage application will be applied 1 hour after the babies are fed. For massage application, apply oil, solution and cream etc. to the baby's skin will not be used. During the massage application, the baby will be placed in prone and supine positions. Massage will be applied to the newborns in the intervention group by the assistant researcher.
Control group: Apart from clinical routine practices, salivary cortisol samples will be taken from newborn babies in the control group and abdominal circumference of the babies will be measured. primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 36 type: ESTIMATED name: Intervention measure: Stress Level measure: Salivary Cortisol Level measure: Comfort Score measure: Bilirubin Level measure: Nutrient ıntake amount measure: Abdominal Circumference Measurement measure: Defecation Frequency sex: ALL minimumAge: 1 Day maximumAge: 28 Days stdAges: CHILD hasResults: False
nctId: NCT06360146 id: 120685123 briefTitle: Early Mobilisation of Post Cardiac Surgery in Geriatrics. overallStatus: ENROLLING_BY_INVITATION date: 2023-04-01 date: 2023-06-01 date: 2024-06-01 date: 2024-04-11 date: 2024-04-11 name: Ahi Evran University Education and Research Hospital class: OTHER briefSummary: Heart and blood vessel problems together referred to as cardiovascular diseases (CVD) include congenital heart disease, cerebrovascular illness, and coronary heart disease.
Older patients undergoing cardiac surgery also experienced improved balance as a result of early mobilization and functional exercises. conditions: Cardiac Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized controlled trial primaryPurpose: TREATMENT masking: NONE maskingDescription: Single count: 100 type: ESTIMATED name: Early mobilisation measure: International Physical Activity Questionnaire measure: Two Minute Walking Test sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: İsmail Ceylan city: Kırşehir state: Merkez zip: 40100 country: Turkey lat: 39.14583 lon: 34.16389 hasResults: False
nctId: NCT06360133 id: VVN001-CCS-301 briefTitle: Study of 5% VVN001 Ophthalmic Solution in Dry Eye Disease overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-03 date: 2026-03 date: 2024-04-11 date: 2024-04-11 name: VivaVision Biotech, Inc class: INDUSTRY briefSummary: This is a Phase 3, randomized, double-Masked, vehicle-controlled, multi-center study designed to evaluate the safety and efficacy of 5% VVN001 Ophthalmic Solution versus vehicle in Chinese subjects with dry eye disease. conditions: Dry Eye studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 700 type: ESTIMATED name: VVN001 Ophthalmic Solution, 5% name: VVN001 Ophthalmic Solution, Vehicle measure: Corneal Fluorescein Staining measure: Eye Dryness sex: ALL minimumAge: 30 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Eye & Ent Hospital of Fudan University city: Shanghai state: Shanghai country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06360120 id: 00023098816 briefTitle: Combining Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Large-vessel Ischemic Stroke overallStatus: RECRUITING date: 2024-04-10 date: 2025-04-10 date: 2025-05-10 date: 2024-04-11 date: 2024-04-11 name: Kafrelsheikh University class: OTHER briefSummary: Along with the current clinical trial, the impact of adding atorvastatin or rosuvastatin in the first 24 hours on the clinical outcomes of first-ever large-vessel ischemic stroke patients treated with clopidogrel assessed through NIHSS, mRS, and possible adverse effects. conditions: Ischemic Stroke studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study will be composed of 2 arms atorvastatin arm, which consisted of 300 patients who received 40 mg daily atorvastatin for 3 months, and the rosuvastatin arm consisted of 300 patients who received 20 mg rosuvastatin daily for 3 months, All the patients in the two groups received open-label clopidogrel at a loading dose of 300 mg and then 75 mg daily till the end of the 3 months primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Our study was single-blinded to the investigators; an independent statistician generated a computer-generated randomization chart with a block size of four in a one-to-one ratio, and participants were randomly assigned to receive either atorvastatin or rosuvastatin by a specially trained and qualified nurse. None of the investigators included in the study knew the patients' assignments. We prepared Sequentially numbered opaque sealed envelopes and 600 labels for each drug labeled Drug A or B. According to the randomization chart, put them into envelopes numbered 1 to 600. Envelopes were attached to the patient's files. Patients were given enrollment numbers starting from 1, which were mentioned in their files. Files with the same number as the patient enrolment number were opened and the patients were assigned to receive drugs A or B. Drug A included atorvastatin bills, and Drug B included rosuvastatin bills. The statistical analysis was performed by an independent statistician. whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 600 type: ESTIMATED name: Atorvastatin 40 Mg Oral Tablet name: Rosuvastatin 20mg measure: the rate of new stroke at 90 days measure: Value of National Institute of Health Stroke Scale (NIHSS) after one week measure: value of Modified Rankin Scale (mRS) at one week measure: value of Modified Rankin Scale(mRS) at three months measure: rate of composite recurrent stroke, myocardial infarction, and death due to vascular events measure: rate of drug adverse effects measure: Drug adverse effects: all side effects related to the drugs of our study will be reported sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kafr Elsheikh University Hospital status: RECRUITING city: Kafr Ash Shaykh zip: 33511 country: Egypt name: mohamed G. Zeinhom, MD role: CONTACT phone: 2001009606828 email: mohamed_gomaa@med.kfs.edu.eg lat: 31.11174 lon: 30.93991 hasResults: False
nctId: NCT06360107 id: 76729 briefTitle: RCT of a Brief Video Intervention Targeting Peer Inclusion to Reduce Depression-related Stigma in Adolescents overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-07 date: 2024-07 date: 2024-04-11 date: 2024-04-11 name: New York State Psychiatric Institute class: OTHER name: Columbia University briefSummary: The goal of this study is to test the efficacy of a brief video intervention emphasizing peer inclusion on depression-related stigma and stigma outcomes (e.g., help seeking attitudes, secrecy) among adolescents 14-18.
Timely identification and treatment of depression in adolescents is a public health priority. However, most youth with depression do not seek treatment, and stigma has been identified as the primary barrier to help-seeking. Experiments have found brief video-based interventions (BVIs), 1-2 minute videos similar to those viewed by youth on social media platforms, based on the principle of "social contact" with individuals affected by a stigmatized condition, effective in reducing depression-related stigma and increasing help-seeking among adolescents. However, given the extreme time constraints of these videos, optimizing the messaging is paramount. Prior research has indicated that concerns about peer social inclusion are fundamental in shaping stigma among adolescents.