The usefulness of carvedilol to prevent decompensation of cirrhosis in patients with TE-LSM ≥ 25 kPa as a surrogate marker for clinically significant portal hypertension, has never been evaluated in a clinical trial. conditions: Asymptomatic Cirrhosis conditions: Clinically Significant Portal Hypertension studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This study will be a national multicentric, phase III, superiority double-blinded randomized controlled trial with two parallel arms: carvedilol versus placebo. The primary end-point will be assessed by the local investigator (hepatologist), blinded of the randomization arm primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 290 type: ESTIMATED name: Experimental group: Patients will be treated with carvedilol. name: Control group: Patients will receive a placebo. measure: To evaluate the effect of low dose carvedilol (<=12.5 mg per day) versus placebo on the occurrence of decompensation of cirrhosis or liver-related death at 36 months sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU Amiens Picardie city: Amiens country: France name: NGUYEN KHAC Eric, Dr role: CONTACT email: nguyen-khac.eric@chu-amiens.fr lat: 49.9 lon: 2.3 facility: CHU Angers city: Angers country: France name: OBERTI FREDERIC role: CONTACT email: froberti@chu-angers.fr lat: 47.46667 lon: -0.55 facility: CHU Beaujon city: Assistance Publique Hôpitaux De Paris country: France name: RAUTOU PIERRE EMMANUEL, Dr role: CONTACT email: pierre-emmanuel.rautou@aphp.fr facility: CHU Jean Minjoz city: Besançon country: France name: WEIL DELPHINE, Dr role: CONTACT email: dweil@chu-besancon.fr lat: 47.24878 lon: 6.01815 facility: CHU Haut Lévêque city: Bordeaux country: France name: DE LEDINGHEN VICTOR, Dr role: CONTACT email: victor.deledinghen@chu-bordeaux.fr lat: 44.84044 lon: -0.5805 facility: CHU Caen city: Caen country: France name: OLLIVIER-HOURMAND Isabelle, Dr role: CONTACT email: ollivierhourmand-i@chu-Caen.fr lat: 49.18585 lon: -0.35912 facility: CH intercommunal de Créteil city: CH Intercommunal De Créteil country: France name: ROSA ISABELLE, dR role: CONTACT email: isabelle.rosa@chi-creteil.fr facility: CHU Clermont Ferrand city: Clermont Ferrand country: France name: ABERGEL ARMAND, Dr role: CONTACT email: aabergel@chu-clermontferrand.fr lat: 45.77966 lon: 3.08628 facility: Hôpital Henri Mondor city: Créteil country: France name: LEROY Vincent, Dr role: CONTACT email: vincent.leroy2@aphp.fr lat: 48.78333 lon: 2.46667 facility: Hôpital Francois Mitterrand city: Dijon country: France name: MINELLO Anne, Dr role: CONTACT email: anne.minello@chu-dijon.fr lat: 47.31667 lon: 5.01667 facility: CHU Grenoble city: Grenoble country: France name: HILLERET Marie-Noelle, Dr role: CONTACT email: mnhilleret@chu-grenoble.fr lat: 45.16667 lon: 5.71667 facility: Centre Hospitalier départemental de Vendée city: La Roche-sur-Yon country: France name: LAGIN Ludovic, Dr role: CONTACT email: ludovic.lagin@ght85.fr lat: 46.66667 lon: -1.43333 facility: Hôpital Huriez city: Lille country: France name: LOUVET ALEXANDRE, Dr role: CONTACT email: alexandre.louvet@chru-lille.fr lat: 50.63297 lon: 3.05858 facility: CHU la Croix Rousse city: Lyon country: France name: LEBOSSE FANNY, Dr role: CONTACT email: fanny.lebosse@chu-lyon.fr lat: 45.74848 lon: 4.84669 facility: CHU de Montpellier city: Montpellier country: France name: URSIC Jose, Dr role: CONTACT email: jose.ursicbedoya@chu-montpellier.fr lat: 43.61092 lon: 3.87723 facility: CHU Hôtel Dieu city: Nantes country: France name: ARCHAMBEAUD Isabelle, Dr role: CONTACT email: isabelle.archambeaud@chu-nantes.fr lat: 47.21725 lon: -1.55336 facility: CHU Avicenne city: Paris country: France name: BLAISE LORAINE, Dr role: CONTACT email: lorraine.blaise@aphp.fr lat: 48.85341 lon: 2.3488 facility: CHU Pitié-Salpêtrière city: Paris country: France name: THABUT DOMINIQUE, Dr role: CONTACT email: dominique.thabut@aphp.fr lat: 48.85341 lon: 2.3488 facility: CHU Saint-Antoin city: Paris country: France name: OZENNE Violaine, Dr role: CONTACT email: violaine.ozenne@aphp.fr lat: 48.85341 lon: 2.3488 facility: CHU de Reims city: Reims country: France name: BERNARD CHABERT Brigitte, Dr role: CONTACT email: bbernard-chabert@chu-reims.fr lat: 49.25 lon: 4.03333 facility: CHU Pontchaillou city: Rennes country: France name: JEZEQUIEL Caroline, Dr role: CONTACT email: caroline.jezequiel@chu-rennes.fr lat: 48.11198 lon: -1.67429 facility: Hôpitaux Universitaires de Strasbourg city: Strasbourg country: France name: TRIPON Simona, Dr role: CONTACT email: simona.tripon@chru-strasbourg.fr lat: 48.58392 lon: 7.74553 facility: CHU de Toulouse city: Toulouse country: France name: BUREAU Christophe, Dr role: CONTACT email: bureau.c@chu-toulouse.fr lat: 43.60426 lon: 1.44367 facility: Hôpital Paul Brousse city: Villejuif country: France name: KOUNIS Ilias, Dr role: CONTACT email: ilias.kounis@aphp.fr lat: 48.7939 lon: 2.35992 hasResults: False