hackint0sh/New-Dataset huggingface dataset:
That's why the aim of this study Is to see the efficacy of giving manual acupuncture with twirling stimulation for pain and stiffness post weight training. The study method will be a Single Blinded Crossover Randomized Controlled Trial which will compare the efficacy of Manual Acupuncture twirling with Manual Acupuncture Sham for post-exercise pain and stiffness . The outcomes consist of Visual Analog Scale, Pain Pressure Threshold, Range of motion of elbow flexor at 24 hours, 48 hours, and 72 hours post weight training conditions: Muscle Soreness conditions: Stiffness of Elbow, Not Elsewhere Classified studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: This research design used a randomized controlled single-blind crossover trial method (Crossover Single Blinded Randomized Control Trial). Reasons for choosing to use the Crossover method because apart from being able to implement it, it can also provide far more output results with a smaller number of subjects.
The research subjects will then receive two treatments spaced 1 week apart which is called a wash out period to eliminate the carry-over effect of the treatment given. Research subjects will undergo randomization . Subjects in group A will undergo manual twisting acupuncture followed by sham manual acupuncture. The subject in group B will receive a sham acupuncture manual followed by a round of manual acupuncture twirling primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: The Participant will be randomized using a computerized table and the Outcome Assessor dont know which Subjects receive the manual acupuncture twirling or sham manual acupuncture on each period whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Manual Acupuncture Twirling, name: Manual Acupuncture Sham measure: Visual Analog Scale measure: Pain Pressure Threshold measure: Range of Motion sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Sport and Exercise Studies, Indonesian Medical Education and Research Institute (IMERI) Research Tower city: Jakarta state: DKI Jakarta zip: 10430 country: Indonesia name: IMERI, Research Center role: CONTACT phone: 29189160 lat: -6.21462 lon: 106.84513 hasResults: False
nctId: NCT06366542 id: 2/2024 briefTitle: Virtual Reality in People With Persistent Postural-Perceptual Dizziness: RCT overallStatus: COMPLETED date: 2022-05-01 date: 2023-12-31 date: 2024-03-01 date: 2024-04-16 date: 2024-04-16 name: University of Jordan class: OTHER briefSummary: This study aimed to compare the effectiveness of virtual reality (VR) and vestibular rehabilitation therapy (VRT) in enhancing balance in individuals with Persistent Postural-Perceptual Dizziness (PPPD). The experimental group received VR combined with VRT and optokinetic stimulation, while the control group received VRT and optokinetic stimulation. The study involved 42 individuals diagnosed with PPPD and administered ten intervention sessions over six weeks. The study also examined the impact of VR on various aspects of PPPD, including dizziness, visual vertigo, mental well-being, sleep quality, fall risk, and overall quality of life. conditions: Vestibular Dizziness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 42 type: ACTUAL name: Vestibular rehabilitation therapy name: Virtual reality exercises name: Optokinetic Stimulation exercises measure: The Niigata Persistent Postural-Perceptual Dizziness Questionnaire (NPQ) measure: The Niigata Persistent Postural-Perceptual Dizziness Questionnaire (NPQ) measure: The Niigata Persistent Postural-Perceptual Dizziness Questionnaire (NPQ) measure: Dizziness Handicap Inventory (DHI) measure: Dizziness Handicap Inventory (DHI) measure: Falls Efficacy Scale International (FES-I) measure: Falls Efficacy Scale International (FES-I) measure: Dynamic Gait Index (DGI) measure: Dynamic Gait Index (DGI) measure: Pittsburgh Sleep Quality Index (PSQI) measure: Pittsburgh Sleep Quality Index (PSQI) measure: Hospital Anxiety and Depression Scale (HADS) measure: Hospital Anxiety and Depression Scale (HADS) measure: Medical Outcomes Study Short Form 12 (SF-12) measure: Medical Outcomes Study Short Form 12 (SF-12) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Royal Medical Services city: Amman country: Jordan lat: 31.95522 lon: 35.94503 hasResults: False
nctId: NCT06366529 id: TJ-IRB202308123 briefTitle: Explore New Magnetic Resonance Technology in Assessment of Renal Dysfunction overallStatus: RECRUITING date: 2023-09-01 date: 2030-09 date: 2030-09 date: 2024-04-16 date: 2024-04-17 name: Zhen Li class: OTHER briefSummary: Currently, renal biopsy is the gold standard for evaluating renal pathology and renal fibrosis, but it is invasive and carries the risk of serious complications; and the sampled tissue is only a small part of the kidney, which is prone to sampling bias. The lack of reliable, comprehensive test results has hindered the research of new anti-fibrotic drugs and delayed the clinical application of effective new drugs. Therefore, the development of a non-invasive dynamic detection method for renal insufficiency and renal fibrosis in vivo is an urgent clinical problem to be solved.
With the continuous development and update of technology, imaging provides a new way to non-invasively evaluate renal fibrosis. Due to the high resolution of soft tissue and the ability to perform multi-parameter analysis, magnetic resonance has developed the diagnosis of renal insufficiency and renal fibrosis from macroscopic simple biomorphological changes to microscopically complex pathophysiological changes. Many imaging techniques measure renal dysfunction and renal fibrosis by assessing the impact of fibrosis on the functional status, physical properties, and molecular properties of the kidney.
In recent years, in the context of precision medicine, artificial intelligence technologies such as radiomics and machine learning are rapidly becoming very promising auxiliary tools in the imaging assessment of renal fibrosis. It can extract and learn features in images with high throughput, make greater use of information in medical images that cannot be recognized by the human eye, and achieve disease diagnosis, prognosis assessment, and efficacy prediction by building models. However, most of the current research is in the preliminary stage, and there are still few studies on the assessment of renal insufficiency and renal fibrosis. I believe that with the continuous improvement of algorithms and the optimization of models, the progress of radiomics and machine learning will be great. To a certain extent, it promotes the development of personalized medicine and precision medicine for patients with renal insufficiency and renal fibrosis. conditions: Renal Insufficiency, Chronic studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 500 type: ESTIMATED measure: ESKD sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Tongji hospital, NO.1095 jiefang avenue status: RECRUITING city: Wuhan state: Hubei zip: 430074 country: China name: Zhen Li, Doctor role: CONTACT email: zhenli@hust.edu.cn lat: 30.58333 lon: 114.26667 hasResults: False
nctId: NCT06366516 id: FUOBGY2024-23 briefTitle: Role of Methylation Test Triage in HPV Positive Women acronym: MTTRIHPW overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-08 date: 2026-02 date: 2024-04-16 date: 2024-04-16 name: Obstetrics & Gynecology Hospital of Fudan University class: OTHER name: Peking Union Medical College Hospital name: Chengdu Women's and Children's Central Hospital name: Guangdong Women and Children Hospital name: Second Hospital of Jilin University name: First Affiliated Hospital of Xinjiang Medical University name: Third Affiliated Hospital of Zhengzhou University briefSummary: The pathological results were used as the gold standard in this study and the investigators analyze the diagnostic value of six gene methylation status (ASTN1 DLX1, ITGA4, RXFP3, SOX17, ZNF671) in triaging high-risk human papillomavirus infection. The sensitivity and specificity of methylation test and cytology in the diagnosis of high-grade cervical lesions are compared in order to providing new methods and basis in improving the accuracy of cervical cancer screening. conditions: Precancerous Cervical Lesion studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Women who aged 25 to 65 years are screened for cervical cancer and they are all positive of high-risk HPV. primaryPurpose: SCREENING masking: NONE count: 10000 type: ESTIMATED name: Methylation Test measure: The sensitivity and specificity of methylation test in detecting CIN2+. measure: KAPPA value of methylation test. sex: FEMALE minimumAge: 25 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Obstetrics and Gynecology Hospital of Fudan University city: Shanghai state: Shanghai zip: 200011 country: China name: Long Sui, Professor role: CONTACT phone: 0086-021-33189900 email: suilong@fudan.edu.cn name: Qing Cong, PHD role: CONTACT phone: 0086-021-33189900 email: qingcong@fudan.edu.cn lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06366503 id: RS-2023-05 briefTitle: Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional Ablative CO2 Laser for Facial Rejuvenation overallStatus: COMPLETED date: 2023-10-03 date: 2023-12-29 date: 2023-12-29 date: 2024-04-16 date: 2024-04-16 name: Revision Skincare class: INDUSTRY briefSummary: This randomized, single-center, double-blinded, split-face, controlled clinical trial was conducted to investigate the tolerability, safety, and efficacy of a post-procedure cream when used immediately after fractional ablative CO2 laser treatment and for 14 days post-procedure with three times daily application in healthy female subjects aged 35 to 65 with moderate to severe global facial overall photodamage (score of 4 to 9 out of the 10-point Modified Griffiths' scale). Furthermore, this clinical trial compared the active post-procedure cream to a comparator anhydrous formulation often paired with skin rejuvenation procedures. This is a cosmetic study with a FDA-regulated device.
A total of 22 healthy female subjects completed the study. conditions: Photoaging conditions: Wrinkle conditions: Skin Laxity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized, Single-Center, Double-Blinded, Split-Face, Controlled primaryPurpose: OTHER masking: DOUBLE maskingDescription: Subjects were randomly assigned to use the active post-procedure cream on one side of the face and the comparator anhydrous formulation on the opposite side of the face.
The products were packaged in the same container and labelled post-procedure cream. This was a double blinded study, where the investigator, study subject, and other study personnel involved in the evaluation of the efficacy or safety were blinded to group during the study. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 23 type: ACTUAL name: Fractional Ablative CO2 Laser name: Facial Cleanser name: Facial Moisturizer name: Sunscreen name: Basic Ointment measure: Investigator Tolerability measure: Incidence of Adverse Events measure: Subject Tolerability measure: Self-Assessment Questionnaire sex: FEMALE minimumAge: 35 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Dermatology Group city: Blue Ash state: Ohio zip: 45242 country: United States lat: 39.232 lon: -84.37827 hasResults: False
nctId: NCT06366490 id: CIP2023-001 briefTitle: Safety and Immunogenicity of Innocell Autologous Cellular Immunotherapy in Recurrent Epithelial Ovarian Cancer overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-12-01 date: 2025-03-01 date: 2024-04-16 date: 2024-04-16 name: PhotonPharma, Inc. class: INDUSTRY briefSummary: Safety and Immunogenicity of InnocellTM Autologous Cellular Immunotherapy Administered in Patients with Recurrent Epithelial Ovarian Cancer conditions: Ovarian Cancer studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: The study is a 2-part design. For each participant, Part 1 will involve tissue procurement and confirmation of the ability to manufacture the Innocell vaccine, followed by Part 2 which is the treatment phase, involving Innocell administration to patients. primaryPurpose: TREATMENT masking: NONE maskingDescription: Open label Phase I trial with no masking count: 8 type: ESTIMATED name: Innocell Autologous Cellular Immunotherapy measure: Saferty and Immunogenicity of Innocell in Ovarian Cancer Patients measure: Safety of Innocell in Ovarian Cancer Patients measure: Immunogenicity of Innocell in Ovarian Cancer Patients measure: Immunogemicity in Ovarian Cancer Patients measure: Immunogenicity of Innocell Vaccine in Ovarian Cancer Patients sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06366477 id: B-ER-103-417 briefTitle: Effects of Vibration Stimulation Combined With Task-oriented Training on Hand Motor Function in Chronic Stroke overallStatus: COMPLETED date: 2017-01-01 date: 2019-06-15 date: 2019-11-15 date: 2024-04-16 date: 2024-04-16 name: National Cheng-Kung University Hospital class: OTHER briefSummary: There is a lack of effective therapies for hand and finger function recovery in people with chronic stroke. This study assessed the effects of combining vibration stimulation with task-oriented training on functional recovery, and treatment persistence. Participants with chronic stroke underwent 24 sessions of vibration stimulation combined with task-oriented training over 12 weeks, in addition to regular therapy. Functional recovery was assessed using the Fugl-Meyer assessment for motor function (FMA-wrist and hand), the Box and Blocks Test (BBT) for hand dexterity, and the Motor Activity Log (MAL) for daily functional activities. Minimal detectable change (MDC) and minimal important difference (MID) criteria were applied to interpret changes in assessment scores. conditions: Rehabilitation conditions: Stroke conditions: Hand Grasp studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 3 type: ACTUAL name: Vibration stimulation combined with task-oriented training measure: Fugl-Meyer assessment - wrist and hand measure: Box and Blocks Test measure: Motor Activity Log measure: Quantitative Electroencephalography Analysis: Delta Brain Symmetry Index sex: ALL minimumAge: 20 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06366464 id: HBS-101-CL-312 briefTitle: A Study of Pitolisant in Patients With Prader-Willi Syndrome overallStatus: RECRUITING date: 2024-04 date: 2026-07 date: 2027-07 date: 2024-04-16 date: 2024-04-16 name: Harmony Biosciences, LLC class: INDUSTRY briefSummary: This is a Phase 3, randomized, double-blind, placebo-controlled, multicenter, global clinical study to assess the efficacy and safety of pitolisant in patients living with Prader-Willi syndrome.
* Other behavioral problems including social withdrawal, stereotypic behavior, hyperactivity/noncompliance, and inappropriate speech conditions: Prader-Willi Syndrome studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 134 type: ESTIMATED name: Pitolisant tablet name: Placebo tablet measure: Change in severity of EDS as measured by Patient-Reported Outcomes Measurement Information System Bank v1.0 - Sleep-Related Impairment (PROMIS-SRI) T-score measure: Change in severity of irritable and disruptive behaviors as measured by the Aberrant Behavior Checklist-Community, Second Edition (ABC-C) Irritability domain measure: Change in overall severity of EDS as measured by the Caregiver Global Impression of Severity for Excessive Daytime Sleepiness (CaGI-S for EDS) measure: Change in overall severity of EDS as measured by the Clinical Global Impression of Severity for Excessive Daytime Sleepiness (CGI-S for EDS) measure: Change in overall severity of irritable and disruptive behaviors as measured by the Caregiver Global Impression of Severity (CaGI-S) for Irritable and/or Disruptive Behaviors measure: Change in severity of hyperphagia as measured by the Hyperphagia Questionnaire for Clinical Trials (HQ-CT), in conjunction with the Food Safe Zone Questionnaire (FSZQ) measure: Change in severity of EDS as measured by the Epworth Sleepiness Scale for Children and Adolescents (ESS-CHAD [parent/caregiver version]) total score measure: Change in severity of other behavioral problems as measured by the Aberrant Behavior Checklist-Community, Second Edition (ABC-C) Hyperactivity/Noncompliance, Inappropriate Speech, Social Withdrawal, and Stereotypic Behavior Domains measure: Percentage of patients reporting TEAEs sex: ALL minimumAge: 6 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Santa Monica Clinical Trials status: RECRUITING city: Los Angeles state: California zip: 90025 country: United States name: Daniel Norman, MD role: CONTACT name: Pooja Patel role: CONTACT phone: (310) 586-0843 email: ppatel@smclinicaltrials.com lat: 34.05223 lon: -118.24368 facility: Atlanta Diabetes Associates status: RECRUITING city: Atlanta state: Georgia zip: 30318 country: United States name: David G. Robertson, MD role: CONTACT name: Amanda Maxson role: CONTACT phone: (404) 844-7775 email: amaxson@atlantadiabetes.com lat: 33.749 lon: -84.38798 hasResults: False
nctId: NCT06366425 id: RECHMPL23_0272 briefTitle: Screening for Chronic Liver Diseases in General Population acronym: HEPGEN overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-05-01 date: 2025-03 date: 2024-04-15 date: 2024-04-17 name: University Hospital, Montpellier class: OTHER name: On-call medical home (MMG) Clermont-Hérault briefSummary: Improving the care of patients with liver diseases in primary care and will allow patients with chronic liver disease to benefit from a course appropriate care. conditions: Fibrosis, Liver studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 260 type: ESTIMATED name: Blood sample then fibroscan measure: Evaluation of the liver fibrosis screening acceptability (FIB-4) measure: Evaluation of the liver fibrosis screening acceptability (FIB-4 and Fibroscan) measure: Prevalence of advanced liver fibrosis by elastometry pulse (Fibroscan®) with a FIB-4 score>2.67 measure: Prevalence of excessive consumption of alcohol measure: Prevalence of a history or drug use measure: The correlation between advanced liver fibrosis and risk factors for liver disease (presence of metabolic syndromes, viral hepatitis, alcool use disorders) measure: prevalence of viral hepatitis measure: Description of socio-demographic characteristics of participants sex: ALL minimumAge: 40 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU de Montpellier city: Montpellier zip: 34295 country: France name: Magdalena MESZAROS, MD role: CONTACT phone: : 04 67 33 02 57 email: m-meszaros@chu-montpellier.fr name: Magdalena MESZAROS role: PRINCIPAL_INVESTIGATOR lat: 43.61092 lon: 3.87723 hasResults: False
nctId: NCT06366412 id: serum Tau-217 in elderly briefTitle: Dexmedetomidine on Postoperative Cognitive Dysfunction and Serum Tau-217 Protein. overallStatus: RECRUITING date: 2024-04 date: 2025-03 date: 2026-03 date: 2024-04-15 date: 2024-04-15 name: Minia University Hospital class: OTHER briefSummary: To assess the effect of Dexmedetomidine on serum Tau-217 protein and its relation to the incidence and severity of postoperative cognitive dysfunction in elderly patients undergoing major surgery under general anesthesia. conditions: Cognitive Impairment studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 94 type: ESTIMATED name: Dexmedetomidine Hydrochloride name: normal saline measure: the effect of dexmedetomidine on serum Tau-217 protein value. measure: to evaluate the postoperative cognitive dysfunction using Mini-Mental State Scale in both the placebo and dexmedetomidine group. measure: Heart Rate changes in the intraoperative period after induction of anesthesia and every 10 minutes till the end of surgery and postoperative period after 1 hour and every hour till 6 hours postoperative then every 6 hours measure: Mean Arterial Blood Pressure changes in the intraoperative period after induction of anesthesia and every 10 minutes till the end of surgery and postoperative period after 1 hour and every hour till 6 hours postoperative then every 6 hours sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Arwa Essam status: RECRUITING city: Minya zip: 61111 country: Egypt name: Arwa essam Essam, assistant lecturer role: CONTACT phone: +201017565658 email: arwty26@gmail.com lat: 28.10988 lon: 30.7503 hasResults: False
nctId: NCT06366399 id: 00156659 briefTitle: The Acute T-Rex (Timing of Resistance Exercise) Study overallStatus: RECRUITING date: 2023-11-15 date: 2024-12-31 date: 2024-12-31 date: 2024-04-15 date: 2024-04-15 name: University of Utah class: OTHER briefSummary: The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus. conditions: Diabetes Mellitus, Type 2 conditions: Insulin Resistance conditions: Glucose Intolerance conditions: Sleep Disturbance conditions: Overweight or Obesity conditions: Insulin Sensitivity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: PREVENTION masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: Resistance Exercise Timing measure: Insulin sensitivity measure: Sleep Duration measure: Sleep Staging measure: Sleep Quality measure: Sleep Efficiency measure: Muscular Strength measure: Perceived Hunger measure: Perceived Fullness measure: Perceived Prospective Food Consumption measure: Glucose Area Under Curve measure: Insulin Area Under Curve sex: ALL minimumAge: 50 Years maximumAge: 74 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Utah HPER E Buildling status: RECRUITING city: Salt Lake City state: Utah zip: 84112 country: United States name: Jason V Thomas, MS role: CONTACT email: jason.v.thomas@utah.edu name: Tanya M Halliday, PhD role: PRINCIPAL_INVESTIGATOR lat: 40.76078 lon: -111.89105 hasResults: False