nctId: NCT06387355 id: SURG-006-23S briefTitle: Diagnosis and Treatment of CAD in Severe PAD After Lower Extremity Revascularization acronym: CAD in sPAD overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2027-08-01 date: 2029-08-01 date: 2024-04-29 date: 2024-04-29 name: VA Office of Research and Development class: FED briefSummary: Peripheral artery disease, lack or blood flow to the legs, has a high prevalence in the Veteran population. In patients with severe peripheral artery disease that requires an endovascular or surgical intervention for lower leg revascularization, the long-term mortality of approximately 50% is worse that most cancers. The goal of this study is to develop a management strategy to improve cardiovascular outcomes in this high-risk peripheral artery disease population after lower extremity revascularization. conditions: Peripheral Artery Disease conditions: Coronary Artery Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This will be a parallel interventional model to assign participants to a treatment strategy in a clinical study primaryPurpose: TREATMENT masking: NONE count: 450 type: ESTIMATED name: Coronary computed topography (CT) angiography with FFR-CT measure: Major adverse cardiovascular events (MACE) measure: Cardiovascular-related death measure: Myocardioal infarction measure: All-cause mortality measure: Amputation-free survival sex: ALL minimumAge: 50 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Rocky Mountain Regional VA Medical Center, Aurora, CO city: Aurora state: Colorado zip: 80045 country: United States name: Clay Quint, MD PhD role: CONTACT phone: 210-606-2940 email: clay.quint@va.gov name: Clay Quint, MD PhD role: PRINCIPAL_INVESTIGATOR lat: 39.72943 lon: -104.83192 facility: North Florida/South Georgia Veterans Health System, Gainesville, FL city: Gainesville state: Florida zip: 32608-1135 country: United States name: Salvatore Scali, MD role: CONTACT phone: 352-376-1611 lat: 29.65163 lon: -82.32483 facility: Louis Stokes VA Medical Center, Cleveland, OH city: Cleveland state: Ohio zip: 44106-1702 country: United States name: Michael Rosenbaum, MD role: CONTACT phone: 216-791-3800 lat: 41.4995 lon: -81.69541 facility: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA city: Pittsburgh state: Pennsylvania zip: 15240 country: United States name: Edith Tzeng, MD role: CONTACT phone: 866-482-7488 lat: 40.44062 lon: -79.99589 facility: Tennessee Valley Healthcare System Nashville Campus, Nashville, TN city: Nashville state: Tennessee zip: 37212-2637 country: United States name: John Curci, MD role: CONTACT phone: 615-327-4751 lat: 36.16589 lon: -86.78444 facility: VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX city: Dallas state: Texas zip: 75216-7167 country: United States name: Shirling Tsai, MD role: CONTACT phone: 469-797-2100 lat: 32.78306 lon: -96.80667 facility: VA Puget Sound Health Care System Seattle Division, Seattle, WA city: Seattle state: Washington zip: 98108-1532 country: United States name: Gale Tang, MD role: CONTACT phone: 800-329-8387 lat: 47.60621 lon: -122.33207 hasResults: False