hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06299332 id: DO611503A briefTitle: Safety and Efficacy of Bi-Polar Radiofrequency for the Treatment of Erectile Dysfunction overallStatus: RECRUITING date: 2023-06-23 date: 2024-05 date: 2025-05 date: 2024-03-07 date: 2024-03-07 name: InMode MD Ltd. class: INDUSTRY briefSummary: The goal of this prospective pilot study is to learn about the Safety and Efficacy of Radiofrequency (RF) for the Treatment of Erectile Dysfunction. This research study is trying to determine if RF therapy is safe and effective in patients with symptoms of erectile dysfunction (ED). conditions: Erectile Dysfunction studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Prospective, open-label clinical study. primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Device treatment measure: Change in ED symptoms, following the RF treatment measure: Change in sexual activity leading to optimal penetration measure: Evaluate efficacy of the RF treatment for erectile function measure: Evaluate efficacy of the RF treatment for erectile function measure: Evaluate efficacy of the RF treatment for erectile function measure: Evaluate efficacy of the RF treatment for hardness of erection measure: Measuring pain level during the procedure sex: MALE minimumAge: 40 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: LC Medical 140 W 58th St, Suite A New York, NY 10019 status: RECRUITING city: New York state: New York zip: 10019 country: United States name: Lanna Cheuck role: CONTACT phone: 929-492-2052 lat: 40.71427 lon: -74.00597 facility: Washington Heights Urology status: RECRUITING city: New York state: New York zip: 10032 country: United States name: Robert Valenzuela role: CONTACT phone: 212-781-9696 lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06299319 id: 149-2021 briefTitle: Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCD acronym: PAP-OCD overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-06 date: 2024-09 date: 2024-03-07 date: 2024-03-07 name: Centre for Addiction and Mental Health class: OTHER briefSummary: Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects. There is interest to see if similar effects may be provided in those with obsessive compulsive disorder (OCD).
The purpose of this study is to evaluate the safety, feasibility, and clinical effects of psilocybin administration in those with OCD. Ten participants with treatment-resistant OCD will receive two doses of 25mg of psilocybin under supportive conditions, two weeks apart. The investigators hypothesize that two sessions of psilocybin 25mg administered under supportive conditions to participants with treatment-resistant OCD will lead to significant reductions in OCD symptoms. conditions: Obsessive-Compulsive Disorder studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: Psilocybin measure: Feasibility of administering psilocybin (25 mg) in adults with treatment-resistant OCD measure: Incidence of adverse events (Safety and Tolerability) measure: Change in the Yale-Brown Obsessive-Compulsive Scale (YBOCS) total score from baseline measure: Proportion of participants who respond to treatment measure: Changes in Patient Health Questionnaire (PHQ-9) from Baseline to Week 3 measure: Change in the Clinical Global Impression (CGI) scale from Baseline to Week 3 measure: Change in the World Health Organization Quality of Life Short Version (WHOQOL-BREF) score from Baseline to Week 3 measure: Change in World Health Organization Disability Assessment Schedule (WHODAS 2.0) from Baseline to Week 3 measure: Change in Generalized Anxiety Disorder (GAD-7) scores from Baseline to Week 3 measure: Changes in behavioural assessments for well-being (Warwick-Edinburgh Mental Wellbeing Scale; WEMWBS) from Baseline to Week 3 sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-10-20 uploadDate: 2024-02-14T17:40 filename: Prot_SAP_000.pdf size: 879497 hasResults: False
nctId: NCT06299306 id: D3250R00116 briefTitle: REACT - REAl Care for AsThma - A Disease Study to Identify Patients With Severe Uncontrolled Asthma acronym: REACT-Asthma overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2026-01-31 date: 2026-01-31 date: 2024-03-07 date: 2024-03-21 name: AstraZeneca class: INDUSTRY briefSummary: This is a multi-center, single-country, single-arm, prospective, disease study to collect real world data of patients with severe uncontrolled asthma in Germany. conditions: Asthma, Bronchial studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1650 type: ESTIMATED measure: Proportion of severe asthma patients with an Asthma Impairment and Risk Questionnaire (AIRQ®) score at baseline, and at 6 and 12 months post enrollment. measure: Changes in the AIRQ® total score measure: Bi-weekly changes in the AIRQ® total score over time measure: Changes in the AIRQ® impairment domain score measure: Changes in the AIRQ® risk domain score measure: Proportion of patients with prescribed use of oral corticosteroids (OCS) measure: Proportion of patients with self-reported OCS use measure: Proportion of patients with a change in other asthma therapies measure: Treatment switches (change in prescribed therapies) over time and time on treatment. measure: Assessment of the patient satisfaction with digital and analog healthcare measure: Assessment of the patient-reported 1-year prior healthcare utilization measure: Assessment of the healthcare provider (physician) satisfaction with digital and analog healthcare measure: Assessment of the provider preferences in digital versus analog healthcare monitoring. measure: Assessment of the patient preferences towards remote monitoring and healthcare delivery. measure: Number and type of recorded comorbidity-related events overall and in patients with self-reported OCS measure: Changes in laboratory parameter - IgE level measure: Changes in lung function parameters - Tiffenau-Index measure: Correlations between environmental factors and patients' asthma exacerbations measure: Correlation between environmental factors and changes in AIRQ® score measure: Changes in laboratory parameter - blood eosinophil measure: Changes in laboratory parameter - blood neutrophil measure: Changes in laboratory parameter - FeNO measure: Changes in laboratory parameter - C-reactive protein (CRP) level measure: Changes in lung function parameters - FEV1 % sex: ALL minimumAge: 18 Years maximumAge: 120 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06299293 id: 21C306 briefTitle: Facial Emotion Recognition in Anorexia Nervosa acronym: FER_AN overallStatus: COMPLETED date: 2023-02-01 date: 2024-02-01 date: 2024-02-01 date: 2024-03-07 date: 2024-03-07 name: Istituto Auxologico Italiano class: OTHER briefSummary: Altered emotional processing is reported in Anorexia Nervosa. However, this capability is generally measured through explicit measures, like self-report questionnaires and facial emotion recognition tasks. Instead, no previous research has investigated implicit emotional processing in this clinical condition. In the implicit facial emotion recognition task grounded on the implicit "redundant target effect", individuals generally respond faster when two identical targets are presented simultaneously rather than when presented alone; moreover, the competitive presence of a distractor (that is another emotion or a neutral expression) affects the correct recognition of the target. The ability to recognize and detect facial expressions is explored about two main emotions, fear and anger, because of their role in the intra- and interindividual psychological processing. conditions: Anorexia Nervosa studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 40 type: ACTUAL name: Facial Emotion Recognition Test measure: Behavioural measure relative to recognition ability measure: Behavioural measure relative to the detection ability sex: FEMALE minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT facility: IRCCS Istituto Auxologico Italiano - Ospedale San Giuseppe city: Piancavallo state: VCO zip: 28824 country: Italy hasResults: False
nctId: NCT06299280 id: Igdir180 briefTitle: The Effect Of Dual-Task Training On Motor And Cognitive Performance In School-Age Children acronym: Dual-task overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-07-15 date: 2024-09-01 date: 2024-03-07 date: 2024-03-15 name: Igdir University class: OTHER briefSummary: The aim of the study is to investigate the effect of dual task training on performance in school-age children. Although studies on this subject in the world are limited, a comprehensive study on school-age children is needed.
As a result of this study, motor and cognitive performance in single-task conditions in typically developing children will be revealed. Additionally, changes in this performance will be detected in dual-task situations. The gains to be obtained as a result of the training will also reveal the importance of implementing dual task training in school-age children. conditions: Healthy conditions: Child, Only studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: randomised controlled primaryPurpose: OTHER masking: DOUBLE maskingDescription: double-blind whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: dual task training name: single task training measure: Physical Activity Questionnaire for Children (PAQ-C) measure: Physical Activity Questionnaire for Adolescent (PAQ-A) measure: Single cognitive task performance measure: 2-minute walk test measure: 30-second sit-stand test measure: 10m walk test. (single-task conditions) measure: 10m walk test. (dual-task conditions) measure: functional reaching test. measure: Visual Analog Scale (VAS) measure: lower extremity lengths assessment sex: ALL minimumAge: 7 Years maximumAge: 15 Years stdAges: CHILD hasResults: False
nctId: NCT06299267 id: Igdir181 briefTitle: The Effect of Dual Task on Manual Skill Performance in Children and Adolescents acronym: Dual-task overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-06-15 date: 2024-07-15 date: 2024-03-07 date: 2024-03-07 name: Igdir University class: OTHER briefSummary: The aim of the study is to investigate the effect of dual-task conditions on manual dexterity performance in typically developing young people and children between the ages of 7-18.
As a result of this study, manual dexterity performance and cognitive performance in single-task conditions in typically developing children and adolescents will be revealed. Additionally, changes in this performance will be detected in dual-task situations. conditions: Child, Only conditions: Adolescent Development studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 100 type: ESTIMATED name: dual task conditions measure: single cognitive task measure: Visual Analogue Scale (VAS) measure: 9-Hole Peg Test.-Single task measure: 9-Hole Peg Test and writing a given paragraph.-Dual task measure: writing a given paragraph.-Single task measure: writing a given paragraph.-Dual task sex: ALL minimumAge: 7 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06299254 id: 21C305 briefTitle: Placebo Effect About Fatigue in Obesity acronym: POF overallStatus: RECRUITING date: 2023-03-01 date: 2024-02-27 date: 2025-03-01 date: 2024-03-07 date: 2024-03-07 name: Istituto Auxologico Italiano class: OTHER name: University of Turin, Italy briefSummary: Fatigue is a central symptom of obesity: it significantly impacts daily functioning, psychological well-being, compliance with physical therapy, and quality of life. However, the full understanding of the origin and treatment of fatigue in obesity is still a matter of debate, requiring further research, especially from new perspectives. From a neuroscientific perspective, fatigue is more than the subjective perception of tiredness resulting from mental or physical exertion or illness. It results in the complex interaction between (bottom-up) sensory input coming from the periphery, and motivational and psychological input, which is related to top-down cognition. In this framework, placebos may affect the output of the top-down cognitive processing by altering the individual evaluation of the ongoing peripheral performance. Indeed, evidence from both healthy conditions and clinical contexts suggests that fatigue can be modulated. The after-effect of such a modulation can be observed not only at a behavioural level, in terms of physical endurance, but also a psychological (i.e., decreased of perceived fatigue) and neurophysiological (changes in brain activity, especially in the fatigue-related components as the RP) levels. conditions: Obesity studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 80 type: ESTIMATED name: Placebo-Natural History measure: Behavioural outcome of fatigue measure: The individual level of perceived fatigue sex: ALL minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT facility: IRCCS Istituto Auxologico Italiano - Ospedale San Giuseppe status: RECRUITING city: Piancavallo state: VCO zip: 28824 country: Italy name: Federica Scarpina, PhD role: CONTACT phone: +39032351 phoneExt: 4003 email: f.scarpina@auxologico.it hasResults: False
nctId: NCT06299241 id: 01C313 briefTitle: Evaluation of Physical Performance in Old Adults With Sarcopenic Obesity acronym: PREFISAR overallStatus: ACTIVE_NOT_RECRUITING date: 2023-04-21 date: 2024-12-31 date: 2024-12-31 date: 2024-03-07 date: 2024-03-07 name: Istituto Auxologico Italiano class: OTHER briefSummary: The primary objectives of the present study are to estimate the sarcopenic proportion in a cohort of obese older subjects who have been hospitalized. The secondary objective is to individuate several clinical variables that differ between the sarcopenic obese patient and the not sarcopenic obese patient. conditions: Obesity conditions: Sarcopenia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 80 type: ESTIMATED measure: Fat free mass measure: Evaluation of lower limb muscle strength measure: Senior Fitness Test (SFT) measure: Physical performance test (PPT) measure: Fat mass measure: Questionnaire SF-12 (Short Form Health Survey) measure: Oswestry Disability Index questionnaire sex: ALL minimumAge: 60 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istituto Auxologico Italiano, Site Piancavallo city: Oggebbio state: Verbania zip: 28824 country: Italy lat: 45.99088 lon: 8.64663 hasResults: False
nctId: NCT06299228 id: HSA briefTitle: Is Sensorimotor Training Effective Following a Distal Radius Fracture? overallStatus: RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-03-07 date: 2024-04-29 name: Hand Surgery Associates LLC class: OTHER name: Touro University Nevada name: Orthopaedic Specialty Group PC, Fairfield briefSummary: The purpose of this study is to compare the short-term outcomes of individuals who have surgery (volar plate) for a wrist (distal radius) fracture who have routine hand therapy treatment versus routine hand therapy treatment and sensorimotor activities. Individuals who meet inclusion criteria at the facilities collecting data will be invited to participate. If they agree to participate, they will randomly and blindly (via concealed envelopes) be assigned to the control (routine treatment) or the sensorimotor treatment group. Data collection will occur at 3- and 6-weeks post initiation of skilled therapy and will include measurement of joint position sense, function via the Patient Rated Wrist and Hand, pain via the Numeric Pain Rating Scale, and range of motion at the digits and wrist. conditions: Distal Radius Fractures studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: Experimental Group name: Control Group measure: Active Joint Position Sense (AJPS) measure: Patient Rated Wrist and Hand Evaluation sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hand Surgery Associates status: RECRUITING city: Olyphant state: Pennsylvania zip: 18447 country: United States name: Nancy Naughton, OTD role: CONTACT phone: 570-780-8681 email: nancynaughton10@gmail.com name: Lori Algar, OTD role: CONTACT phone: 2034514938 email: Lori.Algar@gmail.com lat: 41.46841 lon: -75.60297 hasResults: False
nctId: NCT06299215 id: APHP240044 briefTitle: Factors and Prognosis of Obstructive Pyelonephritis Patients acronym: PYELO-OBS overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-03-01 date: 2026-03-01 date: 2024-03-07 date: 2024-03-28 name: Assistance Publique - Hôpitaux de Paris class: OTHER briefSummary: Acute obstructive pyelonephritis is a condition with a high risk of complications and may require admission to the intensive care unit.
The aim of this study is to describe the population and prognosis of patients admitted to the intensive care unit for the management of acute obstructive pyelonephritis, and to identify factors associated with a poor prognosis in these patients. conditions: Pyelonephritis conditions: Prognostic studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED measure: The primary endpoint will be a combined endpoint of death, and/or stage 3 AKI ( KDIGO classification), and/or non-recovery of renal function. measure: Death measure: Stage 3 Acute kidney injury (KDIGO classification) measure: failure to recover renal function measure: the incidence of acute renal failure defined by KDIGO 1 measure: the incidence of acute renal failure defined by KDIGO 2 and 3 measure: the incidence of Renal replacement therapy measure: the incidence of non-recovery of renal fuction measure: The number of days alive without Renal replacement therapy measure: The number of days alive without catecholamines measure: The number of days alive without antibiotics measure: The number of days alive without measure: Death rate sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Saint Louis city: Paris zip: 75010 country: France name: Maxime Dr COUTROT, MD role: CONTACT name: François DEPRET, MD role: CONTACT lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06299202 id: 69HCL23_0204 id: ID-RCB type: OTHER domain: 2023-A01905-40 briefTitle: Contrast-enhanced Spectral Mammography (CESM) Early Quantitative Evaluation of Tumoral Response and Pathologic Complete Response Prediction for Localized Breast Cancer Treated by Neoadjuvant Chemotherapy acronym: CERePred overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-12 date: 2026-12 date: 2024-03-07 date: 2024-03-07 name: Hospices Civils de Lyon class: OTHER briefSummary: Some types of localised breast cancer, including stage II and III, HER2 positive (Human Epidermal Growth Factor Receptor) or triple negative cancers are treated with primary or neoadjuvant chemotherapy prior to surgical treatment (mastectomy or conservative treatment).
Angiomammography has several advantages over breast MRI in the follow-up of chemotherapy: shorter examination time, shorter appointment time, better tolerated by the patients and without injection of Gadolinium chelates, which have recently been shown to cause definitive brain deposits during repeated injections. Currently, angiomammography is validated in the follow-up of breast cancers treated with neoadjuvant or primary chemotherapy, with an analysis of tumour response currently only morphological, as in breast MRI.
Here, the hypothesis is that the study of tumour enhancement by angiomammography may constitute a new predictive element of histological response: indeed, the performance of an initial angiomammography before treatment (baseline) and then a second angiomammography performed early in relation to the start of chemotherapy, could allow early prediction of which patients will have a complete histological response at the time of the closing surgery. This prospective study is to compare the variation in tumour enhancement, assessed on each of the two examinations using dedicated X-ray consoles, to the final histological result after closure surgery: it is hoped that the relative variation in tumour enhancement would be greater in responding patients. conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 100 type: ESTIMATED name: Diagnostic test measure: The evolution of the relative tumor enhancement (RTEe) (%) between the baseline and early re-evaluation CESM measure: RTEe according to the 3 categories of RCB score measure: The type of enhancement (TE) % sex: FEMALE minimumAge: 35 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hôpital de la Croix Rousse city: Lyon zip: 69004 country: France name: Dorothée TACONET, MD role: CONTACT phone: 0426109185 phoneExt: +33 email: dorothee.taconet@chu-lyon.fr lat: 45.74848 lon: 4.84669 hasResults: False
nctId: NCT06299189 id: 309264 briefTitle: A Therapist Guided Internet-delivered Treatment for Adults With ADHD (Attention Deficit / Hyperactivity Disorder) - an Open Effectiveness Trial in Routine Care acronym: MinADHD overallStatus: RECRUITING date: 2024-01-01 date: 2027-09 date: 2027-09 date: 2024-03-07 date: 2024-03-07 name: Haukeland University Hospital class: OTHER briefSummary: The primary objective of this study is to explore and evaluate the use and utility of a guided Internet-delivered psychological treatment for adults with ADHD with a combined focus on:
i) Evaluating the impact of potential predictors to treatment adherence, treatment response, treatment use and utilty. ii) Evaluating the feasibility, clinical benefits and implementation process of the treatment in routine outpatient care. iii) Evaluate the cost-effectiveness of the treatment program. conditions: ADHD conditions: ADHD - Combined Type conditions: ADHD Predominantly Inattentive Type conditions: ADHD, Predominantly Hyperactive - Impulsive studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 200 type: ESTIMATED name: MinADHD measure: The Adult ADHD Self-Rating Scale measure: Adult ADHD Quality of Life Measure measure: The Patient Health Questionnaire measure: Generalized Anxiety Disorder-7 measure: Personality Disorder Severity ICD-11 measure: EuroQoL 5D-5L sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bjørgvin DPS status: RECRUITING city: Bergen country: Norway name: Gunn Elise Sæthre role: CONTACT phone: 00000000 lat: 60.39299 lon: 5.32415 hasResults: False