hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06378710 id: 22-0219 briefTitle: Haemodynamic and Respiratory Effects of a Low Positive End Expiratory Pressure Associated With a Fluid Challenge in Knee-chest Position acronym: OPTIPEP overallStatus: RECRUITING date: 2023-01-20 date: 2025-01-20 date: 2025-01-30 date: 2024-04-22 date: 2024-04-22 name: University Hospital, Caen class: OTHER briefSummary: The genu pectoral position is a surgical position used for spine surgery. This surgical position will lead to physiological hemodynamic and respiratory changes during the procedure.
The knee-pectoral position notably induces an increase in CRF and improves pulmonary ventilation/perfusion ratios. On the other hand, it has been shown that it is accompanied by a reduction in cardiac output of approximately 15% Protective perioperative ventilation including a tidal volume between 6 and 8 ml/kg of theoretical ideal weight, PEEP and alveolar recruitment maneuvers is applied in the operating room to reduce postoperative pulmonary complications. The application of high PEEP and the performance of recruitment maneuvers induce arterial hypotension through changes in intra- and transpulmonary pressures. However, investigators hypothesize that the deleterious hemodynamic effects of PEEP seem to counterbalance its beneficial respiratory effects in this particular position.
The combination of the effects of the knee-pectoral position and protective ventilation could be potentiated and be the cause of the sometimes severe arterial hypotension observed in clinical practice. Since this position improves pulmonary ventilation perfusion ratios, the investigators hypothesized that a lower PEEP and the elimination of intraoperative recruitment maneuvers could be beneficial from a hemodynamic point of view without being deleterious in terms of perioperative pulmonary complications. An exploratory study was carried out at the CAEN University Hospital in 2021 under the name PEEP POSTURE (CLERS Agreement No. 2198 of February 17, 2021) on 90 patients aiming to collect hemodynamic and respiratory parameters in 3 surgical positions: supine decubitus, ventral decubitus , pectoral genu. No difference was found in the evolution of respiratory compliance. On the other hand, a significant drop in SBP, DBP and MAP in the pectoral position was shown compared to the supine group as well as greater vascular filling.
The investigators therefore hypothesize that a reduction in PEEP and optimization of vascular filling could help reduce the adverse effects on blood pressure linked to the surgical position. conditions: Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 84 type: ESTIMATED name: Optimized PEEP measure: Number of occurrences of a MAP sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CAEN University Hospital status: RECRUITING city: Caen country: France name: Mariam BOUTROS, MD role: CONTACT phone: 02.31.06.31.06 email: boutros-m@chu-caen.fr lat: 49.18585 lon: -0.35912 hasResults: False
nctId: NCT06378684 id: JW22105 briefTitle: To Evaluate the Safety and Pharmacokinetic Interactions in Healthy Volunteers overallStatus: COMPLETED date: 2023-09-10 date: 2023-12-23 date: 2024-01-13 date: 2024-04-22 date: 2024-04-22 name: JW Pharmaceutical class: INDUSTRY briefSummary: The objective is to evaluate the safety and Pharmacokinetic Interactions after adminitration drug(Treatment A or B or A+B) in Healthy Volunteers conditions: Healthy studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: OTHER masking: NONE count: 48 type: ACTUAL name: Group 1: JW0104(Period 1), C2207(Period 2), JW0104 + C2207(Period 3) name: Group 2: JW0104 + C2207(Period 1), JW0104(Period 2), C2207(Period 3) name: Group 3: C2207(Period 1), JW0104 + C2207(Period 2), JW0104(Period 3) name: Group 4: JW0104(Period 1), JW0104 + C2207(Period 2), C2207(Period 3) name: Group 5: JW0104 + C2207(Period 1), C2207(Period 2), JW0104(Period 3) name: Group 6: C2207(Period 1), JW0104(Period 2), JW0104 + C2207(Period 3) measure: Cmax,ss measure: AUCτ,ss sex: ALL minimumAge: 19 Years maximumAge: 55 Years stdAges: ADULT facility: Clinical Trial Center, Severance Hospital city: Seoul country: Korea, Republic of lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06378671 id: ColdCough briefTitle: Single-center Clinical Study on the Safety and Effect of Bronchoscopic Cryotherapy in Patients With Chronic Cough acronym: ColdCough overallStatus: RECRUITING date: 2024-04 date: 2024-07 date: 2024-09 date: 2024-04-22 date: 2024-04-25 name: Guangzhou Medical University class: OTHER name: Ningbo SensCure Biotechnology Co., Ltd. briefSummary: Chronic cough is one of the most common complaints in respiratory specialty clinics, imposing significant economic burden on patients and severely affecting their quality of life. Currently, the pathogenesis of chronic refractory cough remains incompletely understood, and treatment remains a major challenge in clinical practice. Cryotherapy treatment via bronchoscopy has shown efficacy in certain airway diseases, but there is currently no research reporting its effects on chronic refractory cough.
* Monitor vital signs and clinical manifestations. conditions: Chronic Cough studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: a prospective, single-center, double-blind ,randomized controlled clinical trial primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 20 type: ESTIMATED name: General treatment name: Cryotherapy Treatment measure: Device/Surgery-Related Serious Adverse Events measure: Device/Surgery Adverse Event Rate measure: Serious Adverse Event Rate measure: Device Defect Rate measure: Cough Visual Analogue Scale (VAS) measure: Cough frequency within 2 hours measure: Modified Cough Evaluation Tool (CET) measure: Leicester Cough Questionnaire (LCQ) measure: Tracheal Vibratory Cough Stimulation Test measure: Capsaicin Cough Stimulation Test measure: Performance evaluation of Cryotherapy Ablation Equipment measure: Performance evaluation of Cryotherapy Ablation Catheter sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The First Affiliated Hospital of Guangzhou Medical University status: RECRUITING city: Guangzhou state: Guangdong zip: 510163 country: China name: Shiyue Li role: CONTACT phone: +86 13902233925 email: lishiyue@gird.cn lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06378658 id: 22253 briefTitle: A Study to Learn About How Food and Esomeprazole Affect the Level of BAY2927088 in the Blood When Taken Together in Healthy Participants overallStatus: RECRUITING date: 2024-03-29 date: 2024-05-20 date: 2024-05-20 date: 2024-04-22 date: 2024-04-22 name: Bayer class: INDUSTRY briefSummary: Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) mutations.
* ask the participants questions about how they are feeling and what adverse events they are having An adverse event is any medical problem that a participant has during a study. The study doctors keep track of all adverse events, irrespective of whether they think it is related or not to the study treatment. conditions: Advanced Non-small Cell Lung Cancer conditions: EGFR Mutation conditions: HER2 Mutation conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: NONE count: 21 type: ESTIMATED name: BAY2927088 name: Esomeprazole name: Food measure: Cmax for BAY2927088 in plasma measure: AUC for BAY2927088 in plasma measure: Number of participants with treatment-emergent adverse events (TEAEs) sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: PAREXEL International, Baltimore status: RECRUITING city: Baltimore state: Maryland zip: 21225 country: United States lat: 39.29038 lon: -76.61219 hasResults: False
nctId: NCT06378645 id: 2023-01682 briefTitle: Effect of Propofol vs. Sevoflurane on Erections During Narcosis In Transurethral Surgery acronym: PENIS overallStatus: RECRUITING date: 2024-02-01 date: 2026-12-01 date: 2026-12-01 date: 2024-04-22 date: 2024-04-22 name: Etienne Xavier Keller class: OTHER briefSummary: Penile erection is an unwanted event in transurethral (through the urethra) surgeries, which may be associated with adverse outcomes such as impaired access, prolonged operation time, the need to abort the operation, or the necessity for ancillary measures to achieve penile flaccidity, such as the injection of certain medications directly into the penis.
This study aims to determine whether general anesthesia with propofol is more likely to cause intraoperative erections compared to sevoflurane during transurethral operations. conditions: Erection; Incomplete studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: TRIPLE maskingDescription: The authorized study nurse will hand the upcoming envelope with the treatment allocation to the anesthesiologist. The patient and the urologists (who is measuring the outcome) will not know which form of general anesthesia will be performed. Herewith, blankets in the operating room will hide installations used by the anesthesiologists to prevent the urologists witnessing the assigned narcosis form. Before the surgical sign-out, while still scrubbed in and with the patient under anesthesia, the anesthesiologists will ask the urologists about the outcome questionnaire. Together, they will fill in the paper case report form (CRF). whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 200 type: ESTIMATED name: General Anesthesia: Propofol name: General Anesthesia: Sevoflurane measure: Intraoperative Penile Erection measure: Prolongation of the surgery measure: Change in operative strategy measure: Adaptions of instruments or approaches measure: Altered operative outcome measure: Necessity for a drug application to decrease penile tumescence measure: Complications arisen sex: MALE minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Zurich status: RECRUITING city: Zürich zip: 8091 country: Switzerland name: Etienne X Keller, Ass Prof, MD role: CONTACT phone: +41 44 255 54 40 email: etiennexavier.keller@usz.ch lat: 47.36667 lon: 8.54999 hasResults: False
nctId: NCT06378632 id: CLN0011 DETECT-HF briefTitle: AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM acronym: DETECT-HF overallStatus: RECRUITING date: 2022-02-11 date: 2024-07-15 date: 2024-12-01 date: 2024-04-22 date: 2024-04-22 name: Cordio Medical class: INDUSTRY briefSummary: Study Design:
nctId: NCT06378619 id: CSAPG-50 briefTitle: Tapping Test and the Archimedean Spiral for the Differential Diagnosis of Tremor. Machine Learning Approach acronym: MATSEP overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-06 date: 2025-06 date: 2024-04-22 date: 2024-04-22 name: Consorci Sanitari de l'Alt Penedès i Garraf class: OTHER briefSummary: In clinical practice, it is sometimes difficult to establish whether a patient's tremor is due to Parkinson's disease or essential tremor. The distinction is crucial as the health implications differ significantly between the two conditions. Therefore, the present study aims to develop a diagnostic method based on machine learning techniques to help differentiate whether a patient's tremor is due to one condition or the other. To achieve this, 110 patients with tremor, correctly diagnosed with either Parkinson's disease or essential tremor, will participate. They will undergo two diagnostic tests (tapping test and Archimedean spiral) to capture data that can be processed using machine learning techniques. conditions: Tremor conditions: Essential Tremor conditions: Parkinson Disease studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: PROSPECTIVE count: 110 type: ESTIMATED name: Tapping Test name: Archimedes Spiral measure: Sensitivity measure: Specificity measure: Reliability sex: ALL minimumAge: 45 Years maximumAge: 79 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Sant Camil-Consorci Sanitari Alt'Pènedes i Garraf city: Barcelona state: Cataluña zip: 08810 country: Spain name: José Luis Camacho, MD role: CONTACT phone: +34 938960025 email: jlcamacho@csapg.cat name: Noemí Casaponsa role: CONTACT phone: +34 938960025 phoneExt: 43197 email: recerca@csapg.cat name: José Luis Camacho, MD role: PRINCIPAL_INVESTIGATOR lat: 41.38879 lon: 2.15899 hasResults: False
nctId: NCT06378606 id: P.T.REC/012/004907 briefTitle: Effect of Technology on Cognitive Function in Elderly acronym: cogntion overallStatus: RECRUITING date: 2023-07-01 date: 2024-06-01 date: 2024-06-01 date: 2024-04-22 date: 2024-04-22 name: Nourhan Hesham Ali class: OTHER name: Cairo University briefSummary: Cognitive technology therapies, including interactive video gaming, computer soft wares and mobile technology, have been used to implement cognitive training and rehabilitation programs. Potential advantages to using technology-based interventions include enhanced accessibility and cost-effectiveness, providing a user experience to be good communicator, immersive and comprehensive. conditions: Cognitive Impairment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: The aim of study is to find the effects of screen based cognitive therapy on mild dementia in elderly . primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: The aim of study is to find the effects of screen based cognitive therapy on mild dementia in elderly . whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: cognitive therapy measure: Cognitive functions assessment measure: Quality of life survey sex: ALL minimumAge: 65 Years maximumAge: 85 Years stdAges: OLDER_ADULT facility: Nour Ali status: RECRUITING city: Cairo state: Giza zip: 12511 country: Egypt name: Nour Ali, master role: CONTACT phone: 01156860154 email: nourheshame854@gmail.com lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06378580 id: LGF22H160084 id: LGF22H160084 type: OTHER_GRANT domain: Zhejiang Provincial Basic Public Welfare Research Program briefTitle: The Prognostic Impact of Surufatinib for the Treatment of Advanced Pancreatic Ductal Adenocarcinoma overallStatus: COMPLETED date: 2022-07-01 date: 2023-07-01 date: 2024-04-01 date: 2024-04-22 date: 2024-04-22 name: Luo Cong class: OTHER briefSummary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor with a poor prognosis, despite the emergence of chemotherapies, unmet medical needs and limited treatment options still exist for patients with metastatic PDAC (mPDAC). Surufatinib is a small-molecule tyrosine kinase inhibitor that targets vascular endothelial growth factor (VEGFR) 1, 2, 3, fibroblast growth factor receptor 1 (FGFR1), and colony stimulating factor 1 receptor (CSF-1R), and ex vivo experiments have demonstrated its effect on PC models.
A retrospective analysis of patients with PDAC who underwent surufatinib at Zhejiang Cancer Hospital (Hangzhou,China) from July 2022 to July 2023.The database was extracted from the preoperative demographics, blood markers, and surgical pathology information of patients undergoing surufatinib in the investigators' hospital. conditions: Pancreatic Cancer studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 72 type: ACTUAL name: Surufatinib combine immune checkpoint inhibitor name: AG/FOLFIRINOX measure: Median progression-free survival sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Zhejiang Province Cancer Hospital city: Hangzhou state: Zhejiang zip: 310000 country: China lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06378567 id: HCD J8923 briefTitle: A Study to Assess the Effects of Dietary Supplement Drinks on Sleep, Stress and Mood overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-05 date: 2024-05 date: 2024-04-22 date: 2024-04-22 name: The Water Street Collective class: INDUSTRY name: British American Tobacco (Investments) Limited name: HCD Research briefSummary: A home placement, randomized, double blind, placebo-controlled, study to determine the effect of dietary liquid shot beverage products on self-reported measures of sleep, stress and mood on generally healthy participants with current self-reported mild/moderate sleep difficulties (but not clinical insomnia) and mild/moderate stress. conditions: Sleep conditions: Mood conditions: Stress studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Parallel Assignment primaryPurpose: OTHER masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 180 type: ESTIMATED name: Dietary supplement liquid shot beverage products measure: Sleep Disturbance measure: Sleep Impairment measure: Insomnia Severity measure: Restorative Sleep measure: Contentedness/Anxiety measure: Profile of Mood States (POMS) measure: Daily Sleep diary sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Sago Atlanta - The Palisades Complex city: Atlanta state: Georgia zip: 30328 country: United States name: Melissa Hall role: CONTACT phone: 770-396-8700 email: connect@sago.com lat: 33.749 lon: -84.38798 hasResults: False
nctId: NCT06378554 id: IRB00111227 briefTitle: Cereset Research for Performance Improvement in a Hospital Nursing Unit overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2026-05 date: 2024-04-22 date: 2024-04-22 name: Wake Forest University Health Sciences class: OTHER name: Susanne Marcus Collins Foundation, Inc. briefSummary: The purpose of this study is to explore whether an implementation process composed of offering CR to staff in a single hospital nursing unit has any potential impact on unit-level quality measures post-implementation. conditions: Health Personnel conditions: Stress conditions: Anxiety conditions: Job Performance conditions: Insomnia conditions: Depression studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 30 type: ESTIMATED name: Cereset Research measure: Percent of ortho trauma unit staff who complete Cereset intervention sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Wake Forest University Health Sciences city: Winston-Salem state: North Carolina zip: 27157 country: United States name: Dawn C Higgins role: CONTACT phone: 336-716-9447 email: dkellar@wakehealth.edu lat: 36.09986 lon: -80.24422 hasResults: False
nctId: NCT06378541 id: SDR 21-267 briefTitle: Smartphone App Enhanced Facilitation Among Veterans in a Mental Health Inpatient Setting (Project HOPE) acronym: Project HOPE overallStatus: NOT_YET_RECRUITING date: 2024-11-01 date: 2028-10-31 date: 2028-10-31 date: 2024-04-22 date: 2024-04-22 name: VA Office of Research and Development class: FED briefSummary: This study will test whether a new intervention, Virtual Hope Box Enhanced Facilitation (VHB-EF), reduces suicide risk in Veterans after discharge from inpatient psychiatric hospitalization. Additionally, this study will also conduct interviews with Veterans and healthcare providers to explore barriers and facilitators to future adoption of the VHB-EF intervention in healthcare settings. conditions: Suicide Prevention conditions: Suicide Attempt conditions: Suicidal Ideation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 928 type: ESTIMATED name: Virtual Hope Box Enhanced Facilitation name: Enhanced Usual Care measure: Suicide attempts (measured by the Columbia Suicide Severity Rating Scale [C-SSRS] and medical chart review) measure: Suicidal ideation (measured by the Scale for Suicidal Ideation [SSI]) measure: Self-efficacy to resist a future suicide attempt (measured by the Self-Efficacy to Avoid Suicidal Action [SEASA] scale) measure: Ability to cope with stressful situations (measured by the Coping Self-Efficacy [CSE] scale) measure: Reasons to live (measured by the Brief Reasons for Living Inventory [BRFL]) measure: Depression symptoms (measured by the Patient Health Questionnaire [PHQ-9]) measure: Mental Health Treatment Utilization (measured by the Treatment Services Review [TSR]) measure: Demographics measure: Borderline personality disorder features (measured by the Personality Assessment Inventory-Borderline Features Scale [PAI-BOR]) measure: Alcohol misuse (measured by the Alcohol Use Identification Test [AUDIT]) measure: Drug use (measured by the Drug Abuse Screening Test [DAST-10]) measure: Anxiety (measured by the Generalized Anxiety Disorder 7 [GAD-7]) measure: Coping strategies (measured by the Brief-COPE scale) measure: Virtual Hope Box (VHB) frequency measure: VHB app beliefs, usage, and treatment satisfaction sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: VA Ann Arbor Healthcare System, Ann Arbor, MI city: Ann Arbor state: Michigan zip: 48105-2303 country: United States name: Fatima Makki, MPH MSW role: CONTACT phone: 734-845-3623 email: fatima.makki@va.gov name: Courtney L Bagge, PhD MA role: PRINCIPAL_INVESTIGATOR lat: 42.27756 lon: -83.74088 facility: VA Puget Sound Health Care System Seattle Division, Seattle, WA city: Seattle state: Washington zip: 98108-1532 country: United States name: Mark Reger, PhD role: CONTACT phone: 253-583-3295 email: Mark.Reger@va.gov lat: 47.60621 lon: -122.33207 hasResults: False