hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06305442 id: PR-24031 briefTitle: Microbiota Directed Food for Children With Moderate Acute Malnutrition overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-10-31 date: 2026-02-28 date: 2024-03-12 date: 2024-04-24 name: International Centre for Diarrhoeal Disease Research, Bangladesh class: OTHER name: Washington University School of Medicine briefSummary: Moderate acute malnutrition (MAM) refers to a condition characterized by a significant deficit in weight-for-length measurements in children aged 6 to 59 months. It is a crucial public health concern with detrimental effects on child growth, development, and overall well-being. Addressing MAM is crucial to prevent its progression to severe acute malnutrition (SAM) and to ensure healthy child development. To meet the nutritional requirement of MAM children, icddr,b have come up with a novel intervention named microbiota-directed food (MDF), a ready-to-use supplementary food. The investigator propose this efficacy trial to establish the evidence on the effect of this novel intervention on ponderal growth, microbial and proteomic recovery among the children with MAM in comparison to the standard RUSF. conditions: Moderate Acute Malnutrition studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Double blind, randomized, parallel group, clinical trial primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Double blind whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 230 type: ESTIMATED name: Microbiota-Directed Food name: Ready-to-Use Supplementary Food measure: Mean change in Weight-for-Length Z-score (WLZ) measure: Microbial community repair measure: Validated plasma and faecal biomarkers of health status (prioritized Luminex/ELISA panel including mediators of growth, systemic inflammation, gut inflammation/entero-pathogen burden) measure: Mean change in Weight-for-Age Z-score (WAZ) measure: Mean change in Length-for-Age Z-score (LAZ) measure: Mean change in body composition (% body fat mass and % fat-free mass) measure: Bayley Scales of early childhood development (cognitive, motor, language development) sex: ALL minimumAge: 6 Months maximumAge: 24 Months stdAges: CHILD facility: Mirpur Study site city: Dhaka country: Bangladesh name: Dr. Jinat Alam, MPH, MBBS role: CONTACT phone: +8801676742255 email: jinat.alam@icddrb.com lat: 23.7104 lon: 90.40744 hasResults: False
nctId: NCT06305429 id: HABITE briefTitle: Encouraging Positive Parenting Habits acronym: HABITE overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-07 date: 2024-09 date: 2024-03-12 date: 2024-04-02 name: D'Or Institute for Research and Education class: OTHER name: Okinawa Institute of Science and Technology Graduate University briefSummary: This study evaluates the feasibility and preliminary impacts of a new parenting program consisting of a series of educational videos, automatically delivered via a popular texting platform. The program content for the feasibility study is focused on teaching parents strategies to better manage one of the commonly reported challenges that children face, a transition to a non-preferred activity. Parents with young children experiencing behavior difficulties with daily transition routines are invited to participate in the study. conditions: ADHD studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Open, single-group trial primaryPurpose: TREATMENT masking: NONE count: 200 type: ESTIMATED name: HabitE (effective parenting habit) program (in Brazilian Portuguese) measure: Number of videos viewed measure: Percentage of completed daily ratings measure: Participant satisfaction measure: Parent-rated child's difficulties with daily transitions measure: Parent-rated child's impairment related to transition difficulties measure: Inconsistent parenting measure: Use of physical control measure: Hostility toward child measure: Parent Stress measure: ADHD symptoms measure: ODD symptoms measure: Irritability measure: Proactive parenting measure: Use of positive reinforcement sex: ALL minimumAge: 4 Years maximumAge: 10 Years stdAges: CHILD hasResults: False
nctId: NCT06305416 id: 2023/CT/01 briefTitle: A Efficacy and Safety Study of Ranibizumab 10mg/ml Injection (Incepta) in Patients With Diabetic Macular Edema overallStatus: RECRUITING date: 2024-03-20 date: 2025-02 date: 2025-04 date: 2024-03-12 date: 2024-03-13 name: Incepta Pharmaceuticals Ltd class: INDUSTRY name: Institute for Developing Science and Health Initiatives, Bangladesh briefSummary: Macular edema in diabetes, defined as retinal thickening within two disc diameters of the center of the macula, results from retinal microvascular changes that compromise the blood-retinal barrier, causing leakage of plasma constituents into the surrounding retina and consequently retinal edema. Thickening of the basement membrane and reduction in the number of pericytes are believed to lead to increased permeability and incompetence of the retinal vasculature. This compromise of the blood-retinal barrier leads to the leakage of plasma constituents into the surrounding retina with subsequent retinal edema. Hypoxia produced by this mechanism can also stimulate the production of vascular endothelial growth factor (VEGF). Vascular endothelial growth factor (VEGF) increases retinal vascular permeability, causes breakdown of the blood-retina barrier and results in retinal edema.
Diabetic macular edema (DME) is the most common cause of visual reduction in patients with Diabetes Mellitus. The prevalence of DME globally is around 6.8 %. Diabetic Retinopathy (DR) is the most common microvascular complication of diabetes and the leading cause of blindness worldwide. DME is a complication of diabetic retinopathy that affects the macula, which is located at the center of the retina and responsible for central vision. Bangladesh is the 10th country in the world for the number of adults living with diabetes with some 7.1 million (5.3-12.0). In Bangladesh, it is therefore expected that diabetic secondary complications, like DR, will increase along with the rising trend of diabetes mellitus.
The use of therapeutic monoclonal antibodies has revolutionized in the treatment of many diseases. In recent years, millions of patients have been successfully treated with these biological agents. Ranibizumab is one such therapeutic monoclonal antibody for intraocular use. Ranibizumab is a humanized, recombinant, immunoglobulin G1 monoclonal antibody fragment against vascular endothelial growth factor A (VEGF-A) and thus prevents choroidal neovascularization. The small size of ranibizumab allows for enhanced diffusion into the retina and choroid. conditions: Diabetic Macular Edema conditions: Diabetic Retinopathy conditions: Macular Edema conditions: Macular Degeneration conditions: Retinal Disease conditions: Retinal Degeneration studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 70 type: ESTIMATED name: Ranibizumab 10mg/ml Injection name: Lucentis measure: Changes in Best Corrected Visual Acuity (BCVA) from Baseline measure: Changes in Central Subfield Thickness (CST) from Baseline measure: Proportion of patients who lost fewer than 15 letters (approximately 3 lines) from baseline visual acuity measure: Proportion of patients who gained ≥15 letters (approximately 3 lines) from baseline visual acuity measure: Evaluation and comparison of safety between reference vs. test drug. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bangladesh Eye Hospital & Institute status: RECRUITING city: Dhaka zip: 1209 country: Bangladesh name: Dr. Niaz Abdur Rahman role: CONTACT phone: +8801711590333 email: drniazrahman@gmail.com name: Dr. Niaz Abdur Rahman role: PRINCIPAL_INVESTIGATOR lat: 23.7104 lon: 90.40744 hasResults: False
nctId: NCT06305403 id: VEXUS1 briefTitle: VEXUS and NGAL in the Diagnosis and Prognosis of Sepsis-associated Acute Kidney Injury overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-03-18 date: 2025-05-18 date: 2024-03-12 date: 2024-04-23 name: Inonu University class: OTHER briefSummary: In this prospective observational study, patients hospitalized in mixed intensive care unit, aged between 18 and 80, and diagnosed with sepsis and septic shock according to sepsis-3 criteria will be included.
By comparing plasma NGAL and VEXUS scores between groups, the sensitivity and specificity of the VEXUS score in determining AKI will be determined. conditions: Sepsis conditions: Acute Kidney Injury studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: serum creatinin level measure: ngal measure: VEXUS measure: MORTALİTY sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06305390 id: 2022-003905-31 briefTitle: Fully Hybrid 18F-PSMA PET/MRI as One-stop Approach for the Diagnosis of Clinically Significant Prostate Cancer. acronym: RF2021-1237227 overallStatus: RECRUITING date: 2023-12-04 date: 2024-07 date: 2025-07 date: 2024-03-12 date: 2024-04-12 name: IRCCS San Raffaele class: OTHER briefSummary: This project aims to evaluate the role of fully hybrid PET/MRI with 18FPSMA and multiparametric MR imaging (mpMRI) as one-stop approach for the diagnosis of clinically significant prostate cancer (csPCa).
Our main hypothesis is that adding 18F-PSMA PET to mpMRI prior to biopsy, will reduce the number of false negative findings, while at the same time, allowing also to reduce the number of unnecessary prostate biopsies in patients with low-risk, clinically indolent PCa. conditions: Clinical Suspicion of Prostate Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 167 type: ESTIMATED name: PET/MRI measure: To assess the accuracy and the predictive value of fully hybrid 18F-PSMA PET/MRI for the diagnosis of clinically significant prostate cancer (csPCa) measure: To compare the proportion of csPCa missed by 18F-PSMA PET scan or mpMRI alone To report the reduction in the detection of clinically insignificant PCa when combining mpMRI and 18F-PSMA PET sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: U.O. of Nuclear Medicine, ,Ospedale San Raffaele status: RECRUITING city: Milano zip: 20132 country: Italy name: Maria Picchio, MD role: CONTACT phone: 02-26436117 email: Picchio.maria@hsr.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06305377 id: DESPED-T1 study briefTitle: Achieving Rapid, Safe and Sustained Glucose Control in Adolescents With Suboptimally Controlled Type 1 Diabetes Using Advanced Hybrid Closed Loop Systems overallStatus: NOT_YET_RECRUITING date: 2024-03-11 date: 2024-03-30 date: 2024-03-30 date: 2024-03-12 date: 2024-03-13 name: Giulio Frontino class: OTHER briefSummary: The rational of this study is to assess if AHCL systems are able to achieve a better metabolic control (better glucometric data) after 2 weeks, 1 months. 6 months and 1 year after the start, in adolescents in not good glycaemic control. conditions: Diabetes Mellitus, Type 1 studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 20 type: ESTIMATED name: Tandem Control IQ measure: Glucometric data sex: ALL minimumAge: 12 Years maximumAge: 17 Years stdAges: CHILD hasResults: False
nctId: NCT06305364 id: CL-1001 briefTitle: Predicting Adenomatous Polyps in the Colon Using Images of a Human Tongue overallStatus: RECRUITING date: 2023-08-01 date: 2024-12-01 date: 2024-12-01 date: 2024-03-12 date: 2024-03-20 name: Jubaan Ltd. class: INDUSTRY briefSummary: This is a prospective, multicenter, single-arm clinical investigation designed to evaluate the accuracy of the Gixam™ System in identifying subjects with colorectal adenomas compared to optical colonoscopy. Subjects arriving for a standard of care colonoscopy at the investigation site will be offered to participate in the study. Following an informed consent process, images of the subjects' tongue will be obtained with the Gixam™ System and a prediction score will be generated by the Gixam™ AI model. Subjects will thereafter proceed to their SOC colonoscopy, and the Gixam™ score will be compare with colonoscopy findings to evaluate its performance. conditions: Colorectal Neoplasms conditions: Gastrointestinal Microbiome studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE maskingDescription: Gastroenterologist performing standard of care colonoscopy post Gixam test will be blinded to the Gixam prediction score. count: 800 type: ESTIMATED name: Gixam measure: Primary Safety Endpoint - Number of device related adverse events and serious adverse events measure: Primary Efficacy Endpoint - Gixam's diagnostic accuracy sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Westside GI status: RECRUITING city: New York state: New York zip: 10019 country: United States name: Theodore Bortz role: CONTACT lat: 40.71427 lon: -74.00597 facility: NewYork-Presbyterian / Columbia University Irving Medical Center status: RECRUITING city: New York state: New York zip: 10032 country: United States name: Elissa Lynch role: CONTACT name: Daniel Freedberg, MD role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06305351 id: K-757 P008 briefTitle: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of K-757 and K-833 in Overweight/Obese Patients With Type 2 Diabetes overallStatus: RECRUITING date: 2023-12-07 date: 2024-07 date: 2024-07 date: 2024-03-12 date: 2024-03-12 name: Kallyope Inc. class: INDUSTRY briefSummary: This is a multiple dose study to evaluate the safety, tolerability, PK, and PD of K-757 and K-833 when co-administered in overweight/obese patients with Type 2 diabetes mellitus (T2DM) conditions: Obesity conditions: Type 2 Diabetes Mellitus (T2DM) studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 32 type: ESTIMATED name: K-757 and K-833 QD name: K-757 and K-833 BID name: Matching placebo to K-757 and K-833 QD name: Matching placebo to K-757 and K-833 BID measure: Proportion of participants who experienced 1 or more treatment-emergent AEs measure: Proportion of participants who discontinued study medication due to an AE measure: Area under the concentration-time curve [AUC] of plasma K-757 measure: AUC of plasma K-833 measure: Maximum concentration [Cmax] of plasma K-757 measure: Cmax of plasma K-833 measure: Time of maximum concentration [Tmax] of plasma K-757 measure: Tmax of plasma K-833 measure: Clearance [Cl] of plasma K-757 measure: Cl of plasma K-833 measure: Volume of distribution at steady-state [Vdss] of plasma K-757 measure: Vdss of plasma K-833 measure: Half-life [t1/2] of plasma K-757 measure: t1/2 of plasma K-833 sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: QPS Miami status: RECRUITING city: Miami state: Florida zip: 33143 country: United States lat: 25.77427 lon: -80.19366 hasResults: False
nctId: NCT06305338 id: KUK-Ophthalmology-009 briefTitle: Predicting Intraocular Lens Tilt Using OCT Measurements and Partial Least Squares Regression Modelling acronym: Tilt overallStatus: COMPLETED date: 2022-04-12 date: 2023-04-01 date: 2023-04-26 date: 2024-03-12 date: 2024-03-12 name: Johannes Kepler University of Linz class: OTHER briefSummary: During cataract surgery an artificial intraocular lens (IOL) is implanted in the eye to replace the lens and to correct the refraction for distance vision. Misalignment of IOLs can cause severe loss of visual quality. Different types of misalignment are known. Tilt, one type of IOL misalignment is thought to play a negative role for the optical performance in eyes with IOL designs, especially, if they have aspheric, toric, or multifocal optics.
Various methods to measure IOL misalignments have been described. Studies assessing the IOL position have used subjective grading methods at the slit lamp examination or a Scheimpflug camera to assess IOL decentration and tilt. The subjective grading at the slitlamp may display considerable variability between examiners. This method is more qualitative than quantitative and does not allow fine resolution when reporting IOL tilt. The fact that the patient has no standardized target to focus on makes the method even less reliable. Scanning methods such as Scheimpflug photos require a very well dilated pupil exceeding 6mm to assess the IOL position. Additionally, it can be difficult to identify the anatomical structures of the eye that need to be used as points of reference. Scheimpflug camera images have been used for assessing IOL tilt previously, but erroneous results, often due to corneal magnification, have diminished their widespread use. Another possibility to assess tilt is the use of Purkinje reflexes. The light reflections of Purkinje images at ocular surfaces to evaluate ocular alignment have recently been utilized. Since light is reflected at all interfaces of media with a difference in refractive index, these reflections, called Purkinje images, can be used to assess tilt and decentration of IOLs. Two different clinically applicable Purkinjemeter system provide the measurement of IOL decentration and tilt. The main problem with Purkinje meters is accessibility, as there are only a few prototypes available worldwide.
Aim of this study is to measure tilt with two modern OCT based devices and one Scheimpflug camera and to predict the post-operative tilt using partial least squares regression. This method was developed by Wold and introduced to ophthalmology previously. conditions: Intraocular Lens conditions: Cataract studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 110 type: ACTUAL name: Optical Coherence Tomography measure: post operative IOL tilt measure: Comparison of tilt prediction measure: comparion of three measurement methods measure: Comparison of tilt pre- versus post operative sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Matthias Bolz city: Linz state: Oberösterreich zip: 4020 country: Austria lat: 48.30639 lon: 14.28611 hasResults: False
nctId: NCT06305325 id: 35957 briefTitle: Coparenting Intervention to Prevent Postpartum Depression overallStatus: COMPLETED date: 2018-09-23 date: 2019-11-22 date: 2020-02-22 date: 2024-03-12 date: 2024-03-12 name: Brock University class: OTHER name: University of Toronto briefSummary: The goal of this pilot randomized controlled trial was to examine the feasibility and acceptability of an ehealth antenatal coparenting intervention (eACoP) in primiparous Pakistani women. The secondary purpose of the study was to see the effectives of the intervention in prevention postpartum depression in women. Two hundred and twelve primiparous couples were randomized into an intervention or a control group from the Aga Khan University Hospital. Couples were randomized using consecutively numbered sealed envelopes. Couples in the intervention group received the eACoP intervention during pregnancy, consist of eight online videos in addition to the standard care provided at the center. Both the intervention group and control group received standard care. conditions: Postpartum Depression conditions: Anxiety studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: coparenting framework: it has 3 levels. First is the individual level, which consists of the parent's individual characteristics, which comprises of attitudes, parental beliefs, and emotional and mental health. It has a bidirectional relationship with coparenting and the overall inter-parental relationship. Individual child factors, such as temperament may also play a role in shaping the coparenting relationship. The second level is the family level. It comprises the overall interpersonal relationship, referring to the existing ability of couples to demonstrate support and respect for each other. It could influence the coparental relationship or in reverse, the coparental relationship may influence the overall inter-parental relationship. The third level is the extra-familial level. It has two components: support and stress that are based on a stress-coping perspective. The role of environmental support is viewed as enhancing the coparenting relationship primaryPurpose: PREVENTION masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 106 type: ACTUAL name: eHealth Antenatal Coparenting Intervention measure: feasibility-recruitment rate, adherence, and follow-up rate measure: Acceptability- Participants satisfaction measure: Depressive Symptoms measure: anxiety measure: Coparenting Relationship measure: Relationship Satisfaction- couple relationship satisfaction to discriminate between distressed and non-distressed relationship. measure: Postpartum Childcare Stress measure: Infant Development measure: partner support sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Aga Khan University city: Karachi state: SinDH country: Pakistan lat: 24.8608 lon: 67.0104 hasResults: False
nctId: NCT06305312 id: HCI166685 id: 1R01CA282409-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R01CA282409-01 briefTitle: Community Services Navigation to Advance Health Equity in Breast Cancer Screening acronym: B-SINCERE overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2028-09 date: 2028-09 date: 2024-03-12 date: 2024-04-17 name: University of Utah class: OTHER name: National Institutes of Health (NIH) name: National Cancer Institute (NCI) briefSummary: The goal of this study is to evaluate if adding community services navigation to the standard referral process for social needs is an effective and scalable strategy for addressing disparities in follow-up to abnormal breast cancer screening results. The investigators will determine the effectiveness of social needs referrals combined with a community services navigation intervention in the screening mammography setting to improving breast screening outcomes in underserved women. conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 1450 type: ESTIMATED name: Community Service Navigation name: Usual Care measure: Change in participants' level of social needs as measured by the B-SINCERE (Breast-Screener for Intensifying Community Referrals for Health) screener measure: Episode Completion (EC). EC is the name of a dichotomous scale, reported on a 2-point scale that is calculated from patient electronic health record (EHR), with 0=No Breast Cancer Screening completed, 1=Breast Cancer Screening completed. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Utah Health Hospitals/Huntsman Cancer Institute Population Sciences city: Salt Lake City state: Utah zip: 84112 country: United States name: Elissa Ozanne, PhD role: CONTACT phone: 801-213-4130 email: Elissa.Ozanne@hsc.utah.edu name: Tracy Onega, PhD role: SUB_INVESTIGATOR lat: 40.76078 lon: -111.89105 hasResults: False