hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06265662 id: 66701100301 briefTitle: A Digital Health Program for Non-Communicable Disease Prevention in a Workplace Setting in Thailand overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-09 date: 2025-09 date: 2024-02-20 date: 2024-02-20 name: Chulalongkorn University class: OTHER briefSummary: The goal of this quasi-experimental study is to test the effectiveness of a digital health program designed to prevent non-communicable diseases (NCDs) in employees within a workplace setting in Thailand. The main questions it aims to answer are:
* Have unlimited access to individual chat consultations with a healthcare team, including doctors, dietitians, fitness coaches, and psychologists, available from 9:00 AM to 5:00 PM on workdays, excluding public holidays. conditions: Chronic Disease conditions: Noncommunicable Diseases studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single-arm quasi-experimental study for evaluating the effectiveness of a digital health program in weight reduction for the prevention of non-communicable diseases in the Thai workplace setting. primaryPurpose: PREVENTION masking: NONE count: 150 type: ESTIMATED name: A Digital Health Program for Non-Communicable Disease Prevention in a Workplace Setting in Thailand measure: Weight measure: BMI measure: Total cholesterol measure: Triglycerides measure: HDL measure: LDL measure: HbA1c measure: Fasting plasma glucose measure: blood pressure measure: Feasibility (number of consented participants to all eligible participants ratio) measure: Acceptability sex: ALL minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06265649 id: NOM-ALCD briefTitle: Comparison of NOM for ACLD Between Medical and Surgical Ward overallStatus: RECRUITING date: 2024-01-01 date: 2024-03 date: 2024-03 date: 2024-02-20 date: 2024-02-20 name: Ospedali Riuniti Trieste class: OTHER briefSummary: In Europe, patients with acute left colon diverticulitis (ALCD) are usually admitted to surgical wards even when only medical treatment is required. The study compares ALCD non-operative management (NOM) between surgical and non-surgical environments regarding clinical outcomes, hospitalization length(LOS), and follow-up. conditions: Diverticulitis conditions: Colon Disease conditions: Acute Diverticulitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 175 type: ESTIMATED name: NOM measure: Hospitalization length measure: Follow-up and recurrences sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Manuela Mastronardi status: RECRUITING city: Trieste state: TS zip: 34149 country: Italy name: Manuela Mastronardi, MD role: CONTACT phone: 0403994152 phoneExt: 0039 email: manuela.mastronardi@gmail.com name: Alan Biloslavo, MD role: PRINCIPAL_INVESTIGATOR name: Margherita Sandano, MD role: SUB_INVESTIGATOR name: Paola Germani, MD role: SUB_INVESTIGATOR name: Stefano Fracon, MD role: SUB_INVESTIGATOR name: Davide Cosola, MD role: SUB_INVESTIGATOR name: Selene Bogoni, MD role: SUB_INVESTIGATOR name: Nicolò de Manzini, MD role: PRINCIPAL_INVESTIGATOR name: Marina Troian, MD role: SUB_INVESTIGATOR name: Nicola Artusi, MD role: SUB_INVESTIGATOR lat: 45.64953 lon: 13.77679 hasResults: False
nctId: NCT06265636 id: 2006202325523 briefTitle: Electrical Stimulation of the Mandibular Nerve for Pain and Function Management in Temporomandibular Disorders acronym: Origenkine overallStatus: NOT_YET_RECRUITING date: 2024-02-17 date: 2024-12-20 date: 2026-05-15 date: 2024-02-20 date: 2024-02-20 name: OrigenKinesis fisioterapia class: OTHER name: Universidad Rey Juan Carlos briefSummary: Temporomandibular disorders (TMD) encompass dysfunction and pain of the masticatory muscles and temporomandibular joint (TMJ). Pain in the TMJ, restricted jaw movement, and joint sounds are common conditions in this disorder. This can impact patients' ability to perform daily activities such as eating, speaking, laughing, or yawning, significantly affecting their quality of life.
The project's objective is to assess the effectiveness of PENS on the mandibular nerve in this type of condition. conditions: Temporomandibular Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Subjects who participate in the study will receive, in the case of the experimental group, 10 minutes of manual therapy and exercises and 10 minutes of percutaneous electrical nerve stimulation (PENS) guided by ultrasound. In the case of the control group, they will receive 20 minutes of manual therapy and exercises. The treatment will consist of one session per week for three weeks (a total of 3 sessions). Each session will last 30 minutes, of which 10 minutes will be used for the initial evaluation and 20 minutes for the assigned treatment. Two weeks after the last session, a final evaluation without treatment will be performed. primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: Percutaneous nerve stimulation name: Manual therapy name: exercise measure: pain intensity measure: Pressure pain thresholds (PPT) measure: Pain-free mandibular opening range of motion measure: Self-reported quality of life (SF-12) measure: Electromyographic activation rate of the masseter muscle. sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-07-25 uploadDate: 2024-02-10T07:04 filename: Prot_SAP_000.pdf size: 142975 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-07-25 uploadDate: 2024-02-10T07:19 filename: ICF_001.pdf size: 185452 hasResults: False
nctId: NCT06265623 id: UKE-IKPT 2024/01 briefTitle: Intermittent Hypoxemia, Lung Function Decline, Morbidity, and Mortality in COPD (PROSA Study). acronym: PROSA overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2028-09-30 date: 2029-09-30 date: 2024-02-20 date: 2024-02-20 name: Universitätsklinikum Hamburg-Eppendorf class: OTHER briefSummary: This study aims to analyze if patients with chronic obstructive lung disease who experience a decline of blood oxygen saturation during physical exercise have a disease course different from that of COPD patients who do not experience a decline in blood oxygen saturation during exercise. Patients will be followed for a total of 3 years. conditions: Chronic Obstructive Pulmonary Disease (COPD) studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 148 type: ESTIMATED name: No active intervention, but observational follow-up measure: Difference in FEV1(% of LLN) between baseline and end-of-follow-up measure: Difference in all-cause mortality during follow-up between groups measure: Difference in COPD-related mortality during follow-up between groups measure: Difference in frequency of hospital admissions for exacerbation of COPD during follow-up between groups measure: Difference in frequency of hospital admissions for causes other than exacerbation of COPD during follow-up between groups measure: Sensitivity of plasma biomarkers (spec. ADMA and SDMA) to predict the prevalence of exertional desaturation in COPD patients measure: Sensitivity and specificity of plasma biomarkers (spec. ADMA and SDMA) measured at baseline to prospectively predict the slope of lung function decline in COPD patients measure: Sensitivity and specificity of plasma biomarkers at baseline to prospectively predict the mortality rate in COPD patients measure: Difference in incidence and extent of exercise hypoxemia between carriers and non-carriers of single nucleotide polymorphisms (SNPs) in genes of the L-arginine - dimethylarginine pathway measure: Difference in positive and negative predictive value of bicycle ergometry, 6-minute walk test, and 15-sec breath-hold test to discriminate between COPD patients with exertional desaturation versus those without exertional desaturation sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Medical Center Hamburg-Eppendorf, Institute of Clinical Pharmacology and Toxicology city: Hamburg zip: 20246 country: Germany name: Rainer Böger, MD role: CONTACT email: boeger@uke.de name: Juliane Hannemann, PhD role: CONTACT email: j.hannemann@uke.de lat: 53.57532 lon: 10.01534 hasResults: False
nctId: NCT06265610 id: 2022/186 briefTitle: A Comparison Of The Effect Of Target-Controlled Infusion Anesthesia And Inhalation Anesthesia overallStatus: COMPLETED date: 2022-03-01 date: 2023-09-01 date: 2023-10-01 date: 2024-02-20 date: 2024-02-20 name: TC Erciyes University class: OTHER briefSummary: A total of 70 patients who underwent angiographic examination, ASD closure, VSD closure, PDA closure and aortic balloon dilatation were included in this study. conditions: Pediatric Patients conditions: Cardiology studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 70 type: ACTUAL name: TIVA/TCI measure: intraoperative period measure: postoperative period measure: hemodynamic parameters measure: Modified Aldrete Recovery Score sex: ALL minimumAge: 3 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Sibel Seçkin Pehlivan city: Kayseri state: Talas zip: 38039 country: Turkey lat: 38.73222 lon: 35.48528 hasResults: False
nctId: NCT06265597 id: EU-SBE-DŞ-01 briefTitle: The Effect of Healthy Nutrition and Yoga Program on Obese Children overallStatus: ENROLLING_BY_INVITATION date: 2022-09-14 date: 2024-08-02 date: 2024-12-02 date: 2024-02-20 date: 2024-02-20 name: TC Erciyes University class: OTHER briefSummary: This study was planned to examine the effects of a healthy nutrition and yoga program given to obese children on nutritional behavior, physical activity and anthropometric measurements. conditions: Obesity, Childhood studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: There is a control and intervention group. primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Healthy Nutrition and Yoga Program measure: Anthropometric Measurements and Child Follow-up Form measure: Family Nutrition and Physical Activity Scale measure: Adolescent Identification Form sex: ALL minimumAge: 10 Years maximumAge: 14 Years stdAges: CHILD facility: Karaman Provincial Directorate of National Education city: Karaman zip: 70200 country: Turkey lat: 37.18111 lon: 33.215 hasResults: False
nctId: NCT06265584 id: IRB-300011730 (UAB2370) briefTitle: Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell Transplant overallStatus: NOT_YET_RECRUITING date: 2024-06-28 date: 2028-02 date: 2028-05 date: 2024-02-20 date: 2024-04-03 name: University of Alabama at Birmingham class: OTHER briefSummary: In an effort to reduce graft versus host disease (GVHD) and enhance graft versus leukemia (GVL) effect post allogenic hematopoietic stem cell transplantation (AHSCT), recent research has focused on host immune cell depletion. Frame shifting anti-thymocyte globulin (ATG) backwards to earlier days before days 0 can result in deeper host and less graft T-cell depletion, leading to better immune reconstitution. Preliminary data where 80% of the ATG dose is given on days -6,-5,-4 and 20% given on day -1, showed effective prevention of severe acute GVHD, chronic GVHD and favorable early immune reconstitution. We hypothesize that our 2 step ATG dosing platform when combined with standard tacrolimus and mini methotrexate can prevent grade III-IV acute GVHD and chronic GVHD, resulting in improvement of GVHD/relapse free survival at one year post transplant. conditions: Acute Leukemia conditions: Myelodysplastic Syndrome conditions: Myeloproliferative Disorders studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 56 type: ESTIMATED name: ATG dosing platform when combined with standard tacrolimus and mini methotrexate measure: Rate of GRFS (graft versus host disease GVHD, relapse free survival) at one year post transplant. sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Alabama at Birmingham city: Birmingham state: Alabama zip: 35294 country: United States name: Zaid Al Kadhimi, MD role: PRINCIPAL_INVESTIGATOR name: Manuel Espinoza-Gutarra, MD role: SUB_INVESTIGATOR name: Donna Salzman, MD role: SUB_INVESTIGATOR name: Antonio Di Stasi, MD role: SUB_INVESTIGATOR name: Lauren Shea, MD role: SUB_INVESTIGATOR name: Omar Jamy, MD role: SUB_INVESTIGATOR lat: 33.52066 lon: -86.80249 hasResults: False
nctId: NCT06265571 id: EskisehirUO briefTitle: Postoperative Pain in Shoulder Surgery overallStatus: COMPLETED date: 2020-11-15 date: 2021-06-15 date: 2021-07-15 date: 2024-02-20 date: 2024-02-20 name: Eskisehir Osmangazi University class: OTHER briefSummary: After the approval of the ethics committee, the files of the patients who underwent arthroscopic shoulder surgery between 01.01.2019 and 01.03.2020 were evaluated retrospectively.
Data were recorded including age, gender, duration of anesthesia, duration of surgery, postoperative analgesia consumption, complications such as respiratory distress due to hemidiaphragmatic paralysis and complications such as hematoma and nerve damage due to block intervention. conditions: Pain, Postoperative studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 40 type: ACTUAL name: perineural injection measure: rescue analgesia measure: difference between the analgesic methods sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ferda YAMAN city: Eskişehir state: Odunpazarı zip: 26040 country: Turkey lat: 39.77667 lon: 30.52056 hasResults: False
nctId: NCT06265558 id: PROICM 2023-08 TPN briefTitle: Prevention of Postoperative Complications by Negative Pressure Therapy After Complex Breast Cancer Surgery acronym: TPN-SEIN overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2027-02 date: 2027-02 date: 2024-02-20 date: 2024-04-04 name: Institut du Cancer de Montpellier - Val d'Aurelle class: OTHER briefSummary: There is little scientific data concerning the use of negative pressure therapy after immediate breast reconstruction.
The published results therefore strongly encourage further investigation of negative pressure therapy in oncological breast surgery. conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 254 type: ESTIMATED name: Negative pressure therapy (NPT) name: Dressing measure: Rate of patients with post-operative scarring trouble measure: Rate of patients with a surgical site infection measure: Surgical revision rate measure: Rate of patients with at least one rehospitalization measure: Surgical complication rate by Clavien-Dindo classification measure: Time to initiation of adjuvant therapy measure: Quality of life evaluated by questionnaire QLQ-C30 (Version 3) measure: Quality of life evaluated by questionnaire QLQ-BReast cancer (BR23) measure: Patient satisfaction about cosmetic result evaluated using the BR23 questionnaire measure: Medical cost of post-surgery care sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre Hospitalier de Nîmes city: Nîmes state: Gard zip: 30900 country: France name: Fanny BECHARD, MD role: CONTACT email: fanny.bechard@hotmail.fr name: Fanny BECHARD, MD role: PRINCIPAL_INVESTIGATOR lat: 43.83333 lon: 4.35 facility: Centre Hospitalier de Montpellier city: Montpellier state: Hérault zip: 34090 country: France name: Martha DURAES, MD role: CONTACT email: m-duraes@chu-montpellier.fr name: Martha DURAES, MD role: PRINCIPAL_INVESTIGATOR lat: 43.61092 lon: 3.87723 facility: Institut régional du Cancer de Montpellier city: Montpellier state: Hérault zip: 34298 country: France name: Mathias NERON, MD role: CONTACT phone: 467614813 phoneExt: +33 email: mathias.neron@icm.unicancer.fr name: Mathias NERON, MD role: PRINCIPAL_INVESTIGATOR lat: 43.61092 lon: 3.87723 hasResults: False
nctId: NCT06265545 id: RR-AML-2023 briefTitle: Multicenter, Platform-type Clinical Study of Refractory/Recurrent Acute Myeloid Leukemia overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2026-01-30 date: 2026-06-30 date: 2024-02-20 date: 2024-04-16 name: Institute of Hematology & Blood Diseases Hospital, China class: OTHER briefSummary: To study the optimal therapeutic strategies for salvage treatment of refractory/relapsed AML, and to clarify the effectiveness and safety of various salvage treatment options. A prospective, multicenter, platform-type study was conducted to explore the overall response rate, tolerability, and survival of patients with R/R AML with different treatment regimens. conditions: AML conditions: Refractory conditions: Relapsed studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: TREATMENT masking: NONE count: 120 type: ESTIMATED name: Ivosidenib,Venetoclax,gilteritinib,Selinexor measure: Complex response (CRc) rate (including CR and CRi) measure: mortality associated with salvage treatment (30 days, 60 days) measure: MRD-negative complete response rate measure: Overall survival measure: Event-free survival measure: Relapse-free survival sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Blood Hospital city: Tianjin zip: 300020 country: China name: hui wei, MD role: CONTACT phone: 86-13132507161 email: weihui@ihcams.ac.cn lat: 39.14222 lon: 117.17667 hasResults: False
nctId: NCT06265532 id: Pro00060157 id: R33HL158540 type: NIH link: https://reporter.nih.gov/quickSearch/R33HL158540 briefTitle: Collagen-targeted Positron Emission Tomography (PET) Imaging for Assessment of EGCG Effect overallStatus: RECRUITING date: 2024-02-07 date: 2025-05-31 date: 2025-05-31 date: 2024-02-20 date: 2024-02-20 name: Hal Chapman class: OTHER name: Cornell University name: Massachusetts General Hospital name: University of Michigan name: National Heart, Lung, and Blood Institute (NHLBI) briefSummary: The primary purpose of this substudy is to determine if collagen-targeted PET using the type 1 collagen-targeted PET probe, Gallium-68 (68Ga)-labeled collagen binding probe 8 (CBP8) can inform as to drug effect of EGCG and assist in dose selection. conditions: Idiopathic Pulmonary Fibrosis studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: This is an optional substudy to the phase I study: "Dose ranging study of oral epigallocatechin-3-gallate (EGCG) given daily for 12 weeks to patients with Idiopathic Pulmonary Fibrosis (IPF) evaluating safety, PK interactions with standard of care drugs, and biomarkers of drug effect." Up to twenty-two participants participating in the aforementioned study will be enrolled into this sub-study. This substudy will be conducted at a select number of sites with capabilities for performing \[68Ga\]CBP8 PET. primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: All participants will be on one of the standard of care drugs (nintedanib or pirfenidone) and blindly given EGCG or placebo. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 22 type: ESTIMATED name: EGCG 300 mg name: Placebo for EGCG 300 mg name: EGCG 600 mg name: Placebo for EGCG 600 mg measure: Change in collagen probe uptake over the entire lungs measure: Change in peak enhancement over the entire lungs measure: Change in the rate of contrast washin over the entire lungs measure: Change in the area under the curve at 60 seconds over the entire lungs measure: Change in the full width at half maximum over the entire lungs measure: Change in the rate of contrast washout over the entire lungs sex: ALL minimumAge: 40 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Massachusetts General Hospital status: RECRUITING city: Boston state: Massachusetts zip: 02114 country: United States name: Sydney Montesi, MD role: CONTACT phone: 617-724-4030 email: SBMONTESI@PARTNERS.ORG name: Caroline Fromson role: CONTACT phone: 617-643-3260 email: CFROMSON@MGH.HARVARD.EDU name: Sydney Montesi, MD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06265519 id: MAR.UAD.008 briefTitle: Association of Urine BDNF and NGF With Lower Urinary System Parameters overallStatus: RECRUITING date: 2024-02-01 date: 2025-02-01 date: 2025-07-01 date: 2024-02-20 date: 2024-02-21 name: Marmara University class: OTHER briefSummary: Histologically, BPH is a benign proliferative process involving both epithelial and stromal elements and is characterised by progressive enlargement of the prostate. Symptom complex including increased frequency of urination, sudden feeling of urge to urinate, nocturia, difficulty in urinating, feeling of incomplete emptying of the bladder, decreased flow rate and intermittent urination are called lower urinary tract symptoms (LUTS). The most important cause of LUTS in men is BPH. Many structural and physiological changes occur in the lower urinary system with bladder outlet obstruction. Detrusor hypertrophy and bladder hyperactivity may occur due to bladder outlet obstruction. Although the density of afferent and efferent nerves in the bladder decreases after urethral obstruction, enlargement of their trunks indicates that changes occur in these nerves. In addition, changes also occur in the neural pathways of the central nervous system following lower urinary tract obstruction. Nerve growth factor (NGF) and brain derived neurotropin factor (BDNF) are trophic proteins that act as retrograde messengers between peripheral effector tissue and the nerves that innervate it. In peripheral tissues, the source of NGF and BDNF is presumed to be the target tissues innervated by nerves. Smooth muscle cells, fibroblasts, astrocytes and other cells synthesise NGF and BDNF in culture medium. Many potential stimuli that increase NGF in the lower urinary system have been identified. These are denervation, inflammation and mechanical tension. This information has led to the idea that autonomic innervation changes in the bladder may be related with changing NGF levels. Altered afferent and adrenergic innervation in the obstructed bladder increases the possibility that NGF plays an important role in this neural growth because this type of nerves are highly sensitive to this neurotrophin.
In this study, we investigated NGF ve BDNF levels in urine samples obtained before surgery (Transurethral Prostate Resection, Prostate Enucleation with Holmium Laser and Prostate Enucleation with Thulium Fibre Laser) and after removal of obstruction in patients with bladder outlet obstruction secondary to benign prostatic enlargement using ELISA method, We aimed to determine the role of NGF and BDNF in bladder outlet obstruction and bladder changes secondary to obstruction by comparing with control patients without obstruction. conditions: Benign Prostatic Hyperplasia With Outflow Obstruction conditions: Lower Urinary Tract Obstructive Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE maskingDescription: 0 count: 70 type: ESTIMATED name: Holmium laser enucleation of the prostate measure: Uroflowmetry measure: International prostate symptom score measure: Urodynamic sex: MALE minimumAge: 50 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Marmara University Hospital status: RECRUITING city: Istanbul country: Turkey name: Haydar Kamil Çam, Prof. role: CONTACT phone: +905323259547 email: kamilcam@hotmail.com name: Kader Ada Doğan, MD role: CONTACT phone: +905323845598 email: kader.dogan11@gmail.com lat: 41.01384 lon: 28.94966 hasResults: False