hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06281470 id: WS016-Ⅰ-01 briefTitle: The Safety and Tolerability of WS016 in Healthy Chinese Volunteers overallStatus: COMPLETED date: 2023-02-13 date: 2023-06-15 date: 2023-06-15 date: 2024-02-28 date: 2024-02-28 name: Waterstone Pharmaceutical (Wuhan) Co., LTD. class: INDUSTRY briefSummary: This clinic trial evaluates the safety and tolerability of single- and multiple- ascending doses of WS016 in healthy adult participants. There will be about 64 participants,48 active and 16 placebo. conditions: Hyperkalemia studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 66 type: ACTUAL name: WS016 Single Dose(6g) name: WS016 Single Dose(12g) name: WS016 Single Dose(24g) name: WS016 Single Dose(36g) name: WS016 Single Dose(48g) name: SAD matching placebo name: WS016 Multiple Dose(12g) name: WS016 Multiple Dose(24g) name: WS016 Multiple Dose(48g) name: MAD matching placebo measure: Number of participants that experience Adverse Events (AEs) and Serious Adverse Events (SAEs) after single- and multiple- ascending dose sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Zhejiang Xiaoshan Hospital city: Hangzhou state: Zhejiang zip: 310000 country: China lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06281457 id: 5-24-0030: 2.1 id: R01EY035300 type: NIH link: https://reporter.nih.gov/quickSearch/R01EY035300 briefTitle: Probing the Role of Feature Dimension Maps in Visual Cognition: Impact of Task Demands (Expt 2.1) overallStatus: RECRUITING date: 2024-04 date: 2024-05 date: 2024-05 date: 2024-02-28 date: 2024-04-18 name: University of California, Santa Barbara class: OTHER name: National Eye Institute (NEI) briefSummary: How does one know what to look at in a scene? Imagine a "Where's Waldo" game - it's challenging to find Waldo because there are many 'salient' locations in the picture, each vying for one's attention. One can only attend to a small location on the picture at a given moment, so to find Waldo, one needs to direct their attention to different locations. One prominent theory about how one accomplishes this claims that important locations are identified based on distinct feature types (for example, motion or color), with locations most unique compared to the background most likely to be attended. An important component of this theory is that individual feature dimensions (again, color or motion) are computed within their own 'feature maps', which are thought to be implemented in specific brain regions. However, whether and how specific brain regions contribute to these feature maps remains unknown.
The goal of this study is to determine how brain regions that respond strongly to different feature types (color and motion) and which encode spatial locations of visual stimuli transform 'feature dimension maps' based on stimulus properties as a function of task instructions. The investigators hypothesize that feature-selective brain regions act as neural feature dimension maps, and thus encode representations of relevant location(s) based on their preferred feature dimension, such that the stimulus representation in the most relevant feature map is up-regulated to support adaptive behavior. The investigators will scan healthy human participants using functional MRI (fMRI) in a repeated-measures design while they view visual stimuli made relevant based on a cued feature dimension (e.g., color or motion). The investigators will employ state-of-the-art multivariate analysis techniques that allow them to reconstruct an 'image' of the stimulus representation encoded by each brain region to dissect how neural tissue identifies salient locations. Each participant will perform a challenging discrimination task based on the cued feature (report motion direction or color of stimulus dots) of a stimulus presented in the periphery, which are identical across trial types. Across trials the investigators will manipulate the attended feature value (color, motion, or fixation point). This manipulation will help the investigators fully understand these critical relevance computations in the healthy human visual system. conditions: Basic Science: Visual Attention in Healthy Participants conditions: Basic Science: Neural Representations of Location studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This is a basic science study in which all participants will participate in all task conditions within each experiment (repeated-measures design). primaryPurpose: BASIC_SCIENCE masking: NONE maskingDescription: Participants will typically be unaware of the conditions presented, though because these involve manipulations of stimuli or task demands, they may be aware of the manipulation. This is not expected to impact the primary outcome measures (e.g., BOLD signal activation patterns). count: 10 type: ESTIMATED name: Stimulus properties: task-defining feature measure: Blood Oxygenation Level Dependent (BOLD) fMRI signal measure: Gaze position measure: Behavioral response (button press) sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: University of California, Santa Barbara status: RECRUITING city: Santa Barbara state: California zip: 93117 country: United States name: Melodie Blakemore role: CONTACT phone: 805-893-4286 email: blakemore@research.ucsb.edu name: Tommy C Sprague, PhD role: PRINCIPAL_INVESTIGATOR lat: 34.42083 lon: -119.69819 hasResults: False
nctId: NCT06281444 id: i07-453-23 briefTitle: Effectiveness of Radial Extracorporeal Shock Wave Therapy in Patients With Knee Osteoarthritis overallStatus: RECRUITING date: 2024-01-01 date: 2025-01-31 date: 2025-07-31 date: 2024-02-28 date: 2024-02-28 name: Ankara University class: OTHER briefSummary: Osteoarthritis (OA) is a degenerative joint disease characterized by unsuccessful repair of joint damage resulting from stresses in any of the synovial joint tissues. Symptoms include pain (initially only after movement), joint stiffness, limitation of joint movement, feeling of insecurity in the joint, and difficulty walking. The diagnosis of knee osteoarthritis can be easily made with a detailed history and a comprehensive physical examination. Radiographic examinations are used to support clinical findings and exclude other possible pathologies. The main purpose of treating knee osteoarthritis is to reduce pain and make daily life easier. Since there is no standard treatment method, the patient's treatment must be individualized by taking into account age, comorbidity, severity of the clinical picture, patient preferences and cost of treatment. Conservative treatment includes pharmacological and non-pharmacological treatment, and the optimal treatment should be applied as a combination of these two methods. Patient education, lifestyle modification, exercise, different physical therapy modalities (TENS, Interferential current, ESWT...), acupuncture are some non-pharmacological methods.
Extracorporeal shock wave therapy (ESWT), which is considered within the scope of conservative treatment, started in the seventies with the practice of breaking ureteric stones and has become one of the physical therapy modalities used in the treatment of various musculoskeletal diseases. Considering the historical development of ESWT, it has started to be used as a therapeutic modality in the treatment of knee osteoarthritis in recent years. The process, which started with animal experiments, continued with human studies, and evidence is presented that ESWT reduces knee pain and contributes to functionality. It is noteworthy that there are few studies and their short follow-up periods. In the light of these studies, it was planned to investigate the effectiveness of ESWT treatment, which will be applied together with exercise, on pain, functionality and walking distance in individuals diagnosed with knee osteoarthritis, in comparison with the control group receiving sham ESWT. conditions: Knee Osteoarthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients who accepted to participate in the study by meeting the criteria will be randomly divided into two groups as the first group treatment ESWT + exercise, the second group sham ESWT + exercise. primaryPurpose: TREATMENT masking: NONE maskingDescription: Patients who meet the study conditions and agree to participate in this study will not know whether they are in the first group or the second group. count: 72 type: ESTIMATED name: ESWT name: Sham-ESWT measure: Change in pain [by using the Visual Analogue Scale(VAS)] measure: Change from baseline in functionality and walking distance measure: Change from baseline in walking distance sex: ALL minimumAge: 50 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ankara University status: RECRUITING city: Ankara state: Altındağ zip: 06230 country: Turkey name: Birkan Sonel Tur, Prof. Dr. role: CONTACT phone: +903125956331 email: sonelb@medicine.ankara.edu.tr name: Taha Can Başar, Dr. role: CONTACT phone: +90312595 6331/2822 email: tahacan06@outlook.com name: Birkan Sonel Tur, Prof. Dr. role: PRINCIPAL_INVESTIGATOR name: Taha Can Başar, Dr. role: SUB_INVESTIGATOR lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06281431 id: CPSP briefTitle: A Comparative Effect of Echogenic Needle for Nerve Block on Acute and Chronic Postoperative Pain overallStatus: RECRUITING date: 2023-06-12 date: 2025-09-30 date: 2025-09-30 date: 2024-02-28 date: 2024-02-28 name: The Second Affiliated Hospital of Chongqing Medical University class: OTHER briefSummary: Surgical pain is a common complication after surgery, affecting patient recovery and treatment quality. \>20% of patients suffer from chronic postoperative pain. China has \>70 million surgeries yearly. Nerve block manages postoperative pain, with developing nerve block needles now used in clinics. Developed needles may have better pain management effects than non-developed ones, but their effect on reducing chronic pain remains unclear. This study aims to explore the effect of developed nerve block needles on postoperative pain and compare them to non-developed needles, providing new ideas and methods for pain management. conditions: Chronic Postoperative Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 1000 type: ESTIMATED name: Echogenic nerve block needle name: Non-echogenic nerve block needle measure: Chronic postoperative pain measure: Moderate to severe pain measure: Acute postoperative pain measure: Acute postoperative pain measure: Acute postoperative pain measure: Puncture operation time measure: Number of needle passes sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: He Huang status: RECRUITING city: Chongqing state: Chongqing zip: 4000000 country: China name: He Huang, ph.D role: CONTACT phone: 13708385559 email: huanghe@cqmu.edu.cn lat: 29.56278 lon: 106.55278 hasResults: False
nctId: NCT06281418 id: 5-24 briefTitle: Postoperative Intraperitoneal Pain Management Following Laparoscopic Cholecystectomy overallStatus: RECRUITING date: 2024-02-29 date: 2024-10 date: 2024-10 date: 2024-02-28 date: 2024-04-17 name: Future University in Egypt class: OTHER briefSummary: Postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. No. study has investigated IP granisetron as an adjuvant to standard care for postoperative pain management in patients undergoing LC. conditions: Post Operative Pain studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 46 type: ESTIMATED name: Granisetron 1 Mg/mL Intravenous Solution name: Normal saline measure: VAS score measure: Time to analgesic request measure: Quality of life (QoL) after laparoscopic cholecystectomy (LC) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Hepatology and Tropical Research Institute status: RECRUITING city: Cairo zip: 11617 country: Egypt name: Hoda Mohamed Bayoumi, Bachelor's role: CONTACT phone: 01126143971 email: hoda.bayoumy@fue.edu.eg lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06281405 id: FDRT-2023-290-3409 briefTitle: CAPOX and PD-1 Antibody Combined With or Without Radiotherapy for MSS Locally Advanced Rectal Cancer acronym: TORCH-iTNT overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-06-30 date: 2028-12-31 date: 2024-02-28 date: 2024-02-28 name: Fudan University class: OTHER briefSummary: TORCH-iTNT is a prospective, multicentre, randomized phase II trial. 198 LARC (T3-4/N+M0, distance from anal verge ≤12cm) patients will be treated with total neoadjuvant therapy (TNT) and assigned to Group A and Group B (1:1). Group A receives 6 cycles of Toripalimab combined with CAPOX (ToriCAPOX). Group B receives SCRT (25Gy/5Fx) followed by 6 cycles of ToriCAPOX. TME surgery is scheduled after TNT while a watch and wait (W\&W) option can be applied to patients achieving clinical complete response (cCR). The primary endpoint is complete response (CR, pathological complete response \[pCR\] plus cCR) rate. The secondary endpoints include the grade 3-4 acute adverse effects (AE) rate, anal preservation rate, 3-year DFS rate, etc. conditions: Locally Advanced Rectal Cancer conditions: Neoadjuvant Therapy studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 198 type: ESTIMATED name: PD-1 antibody name: Capecitabine name: Short-course radiotherapy measure: Complete response (CR) rate measure: Grade 3-4 adverse effects rate measure: 3 year anal preservation rate measure: 3 year disease free survival rate measure: 3 year local recurrence free survival rate measure: 3 year overall survival rate measure: Rate of surgical complications sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fudan University Shanghai Cancer Center city: Shanghai country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06281392 id: CEIm: 106/23 briefTitle: Artificial Intelligence and Dysplasia Detection in Inflammatory Bowel Disease (EIIDISIA Study) overallStatus: RECRUITING date: 2023-11-15 date: 2026-11-15 date: 2026-11-15 date: 2024-02-28 date: 2024-02-28 name: Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana class: OTHER name: University of Valencia briefSummary: Randomized clinical study analyzing the efficacy of colonoscopy assisted by the Computer Aided Detection (CADe) system compared to virtual chromoendoscopy with Narrow Band Imaging (NBI) in the detection of colon dysplasia in patients with long-standing inflammatory bowel disease (IBD). conditions: Inflammatory Bowel Diseases conditions: Dysplasia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 122 type: ESTIMATED name: CADe system name: NBI measure: "Per lesion" dysplasia detection rate (DDR) measure: "Per patient" dysplasia detection rate (DDR) measure: Duration of endoscopic examination sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Antonio López-Serrano status: RECRUITING city: Valencia zip: 46017 country: Spain name: Antonio López-Serrano, Ph.D. role: CONTACT phone: 0034656495490 email: anlopezs@comv.es lat: 39.46975 lon: -0.37739 hasResults: False
nctId: NCT06281379 id: Basaksehir City Hospital briefTitle: Complete Mesogastric Excision With D2 Lympadenectomy for Gastric Cancer: overallStatus: COMPLETED date: 2023-04-01 date: 2023-12-31 date: 2024-01-01 date: 2024-02-28 date: 2024-02-28 name: Başakşehir Çam & Sakura City Hospital class: OTHER_GOV briefSummary: Objective: To define complete mesogastric excision and compare our short term results for the first time in a different population.
Conclusion: Our aim is to show that mesogastric excision is safe and has advantages over conventional D2 gastrectomy in means of not only peroperative and short-term outcomes, but also disease free survival.Our work is the first study from a different population of the world and our initial results can contribute to the literature for universalization. conditions: Gastric Cancer conditions: Gastric Neoplasm conditions: Gastric Cancer Stage studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Study group participants: total gastrectomy+mesogastrectomy Control group: Standard total gastrectomy + D2 lymph node dissection primaryPurpose: TREATMENT masking: NONE count: 37 type: ACTUAL name: Total mesogastrectomy measure: Postoperative outcome sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Yigit Duzkoylu city: Istanbul zip: 34480 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06281366 id: PR(AMI)470-2023 briefTitle: Diamine Oxidase and Adverse Pregnancy Outcomes overallStatus: RECRUITING date: 2024-02-16 date: 2025-12-31 date: 2025-12-31 date: 2024-02-28 date: 2024-03-20 name: Hospital Universitari Vall d'Hebron Research Institute class: OTHER name: DR Healthcare briefSummary: In normal pregnancies, blood histamine concentration remains within normal values; however, the serum histaminolytic activity is increased. Histamine is mainly produced by mast cells, platelets, basophils, neurons and enterochromatin cells, where it is stored and released when required. Reduced DAO activities have been found in high-risk pregnancies. Lower DAO activity has been associated to miscarriage, fetal demise, preeclampsia, low birthweight and preterm birth. The placenta is very rich in DAO activity and is the principal source of increased histaminolytic activity in normal pregnancies.
First-trimester screening for preeclampsia (PE) is a routine screening which is performed in the first trimester. Women with a positive result are at a greater risk of PE but also other pregnancy complications such as stillbirth, preterm birth and low birthweight. These cases are prescribed aspirin until term. This intervention has demonstrated to significantly reduce the risk of PE and other complications. Unfortunately, aspirin does not avoid all cases with adverse outcomes, indicating that additional mechanisms may be involved in the development of such pregnancy complications, such as DAO decreased activity. conditions: Pregnancy Complications studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 75 type: ESTIMATED measure: Diamine oxidase activity first trimester measure: Diamine oxidase gene polymorphisms measure: Blood Diamine oxidase activity at delivery measure: Placental Diamine oxidase activity at delivery measure: Blood histamine levels at delivery measure: Placental histamine levels at delivery measure: Urine histamine levels at delivery sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Manel Mendoza status: RECRUITING city: Barcelona zip: 08035 country: Spain name: Manel Mendoza, PhD role: CONTACT phone: +34934893085 email: manel.mendoza@vallhebron.cat name: Erika Bonacina, PhD role: CONTACT phone: +34934893264 email: erika.bonacina@vallhebron.cat name: Erika Bonacina, PhD role: SUB_INVESTIGATOR name: Manel Mendoza, PhD role: PRINCIPAL_INVESTIGATOR name: Mireia Armengol, MD role: SUB_INVESTIGATOR lat: 41.38879 lon: 2.15899 hasResults: False
nctId: NCT06281353 id: 22-07-0754 briefTitle: The Effect of Oral Nanocurcumin as an Adjuvant Therapy for Anogenital Warts: Evaluation of Clinical Improvement, NFĸB, IFN-γ, and FOXP3+TReg From Lesions Tissue overallStatus: COMPLETED date: 2022-08-16 date: 2023-09-06 date: 2023-09-06 date: 2024-02-28 date: 2024-02-28 name: Indonesia University class: OTHER briefSummary: The goal of this clinical trial is to demonstrate the adjuvant administration of oral nanocurcumin in 90% TCA therapy that increases the proportion of clinical improvement in patients with Anogenital Warts (AGW), mediated by NFĸB, IFN-γ, and FOXP3+Treg. Specific objectives of this clinical trial include:
Participants will be divided into 2 groups. The first one was given capsules without active ingredients/nanocurcumin (control group), and the second one was given capsules with nanocurcumin (experimental group), both group received a dosage of 200mg capsules per day after breakfast, for 8 weeks. The researchers conducted a comparison between those 2 groups to assess whether the adjuvant administration of oral nanocurcumin in 90% TCA therapy enhances the proportion of clinical improvement in patients with AGW. conditions: Anogenital Wart studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 78 type: ACTUAL name: Curcumin Oral Capsule name: Trichloroacetic acid name: Blood sample collection name: Cotton swab measure: Clinical improvement in patients with AGW measure: Level of IFN-γ in lesions of AGW patients measure: Level of FOXP3+Treg in lesions of AGW patients measure: Level of NFĸB in lesions of AGW patients sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Cipto Mangunkusumo Hospital city: Jakarta Pusat state: DKI Jakarta zip: 10430 country: Indonesia lat: -6.1818 lon: 106.8223 hasResults: False
nctId: NCT06281340 id: He-ankle US briefTitle: Changes in Intra-articular Parameters by Doppler Ultrasound in Patients With Hemophilic Ankle Arthropathy overallStatus: NOT_YET_RECRUITING date: 2024-02-28 date: 2024-04-10 date: 2024-04-21 date: 2024-02-28 date: 2024-02-28 name: Investigación en Hemofilia y Fisioterapia class: NETWORK briefSummary: Introduction: Hemophilic ankle arthropathy is manifested by functional degenerative alterations, intra-articular alterations, and chronic pain. Manual therapy techniques are used in the treatment of hemophilic ankle arthropathy for the improvement of pain and mobility.
Expected results: Check the safety of manual therapy in patients with hemophilia regarding subclinical bleeding. Assess changes related to joint inflammatory state with imaging techniques. Observe changes in pain intensity and joint damage. conditions: Hemophilia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: DOUBLE maskingDescription: Randomization will be performed using a computerized randomization procedure by permuted blocks of 4 subjects in each recruitment center. The 6 possible sequence alternatives will be modified in each block. This task will be carried out by a person who is not involved in the study and who will not know the identity of the subjects. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 20 type: ESTIMATED name: Manual therapy name: Placebo therapy measure: Change from baseline sonographic changes after 4 hours measure: Change from baseline joint pain after 4 hours measure: Change from baseline joint damage after 4 hours measure: Change from baseline degree of joint inflammation after 4 hours sex: MALE minimumAge: 30 Years maximumAge: 55 Years stdAges: ADULT facility: University of Oviedo city: Oviedo state: Asturias zip: 33006 country: Spain lat: 43.36029 lon: -5.84476 hasResults: False