hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06321484 id: 23-493 briefTitle: Intraperitoneal Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cells in Recurrent Ovarian Cancer overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-11-30 date: 2031-10-31 date: 2024-03-20 date: 2024-03-20 name: Dana-Farber Cancer Institute class: OTHER name: ImmunityBio, Inc. briefSummary: The goal of this research study is to evaluate the safety and effectiveness of the use of cytokine-induced memory-like (CIML) natural killer (NK) cell therapy combined with IL-15 superagonist (N-803) in recurrent, high grade ovarian cancer (HGOC).
* N-803 (a novel immune-cell stimulator) conditions: Platinum-resistant Ovarian Cancer conditions: Recurrent Ovary Cancer conditions: Ovarian Cancer conditions: Ovarian Carcinoma conditions: Ovarian Carcinoma, Recurrent studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 18 type: ESTIMATED name: Cytokine-Induced Memory-like Natural Killer Cells name: IL-15 Superagonist measure: Maximum Tolerated Dose (MTD) (Cohort 1) measure: Dose Limiting Toxicity (DLT) (Cohort 1) measure: Overall Response Rate (ORR) measure: Median Progression Free Survival (PFS) measure: Clinical Benefit Rate (CBR) measure: Duration of Response (DOR) measure: 6 months Progression Free Survival (PFS6) sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Brigham and Women's Hospital city: Boston state: Massachusetts zip: 02215 country: United States name: Rebecca Porter, MD, PhD role: CONTACT phone: 617-632-2334 email: rebecca_porter@dfci.harvard.edu name: Rebecca Porter, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Dana-Farber Cancer Institute city: Boston state: Massachusetts zip: 02215 country: United States name: Rebecca Porter, MD, PhD role: CONTACT phone: 617-632-2334 email: Rebecca_Porter@dfci.harvard.edu name: Rebecca Porter, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06321471 id: STUDY00002858 briefTitle: AeviceMD for Pediatric Asthma Management acronym: APAM overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-02 date: 2026-02 date: 2024-03-20 date: 2024-03-20 name: Irina Dralyuk class: OTHER name: AEvice Health Pte Ltd briefSummary: A wearable remote patient monitor (AeviceMD) is to be used to monitor the respiratory health of pediatric asthma patients in this pilot study. Patients prescribed with AeviceMD should be able to gain better control over their disease during home management. Physicians should be able to optimize treatment for these patients using objective data collected from and of these patients outside of the clinic. The AeviceMD should also be used as a remote auscultation device for teleconsultations. conditions: Asthma conditions: Asthma in Children conditions: Pediatric Asthma conditions: Chronic Respiratory Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: AeviceMD measure: To evaluate the effectiveness of implementing home monitoring technology for asthma patients in delivering care to patients and in extension determine, if Aevice Medical Device can improve home management of Asthma for pediatrics patients. measure: To determine if the AeviceMD is effective as a remote auscultation tool for the facilitation of teleconsultations. sex: ALL minimumAge: 3 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Cedars-Sinai Medical Center city: Los Angeles state: California zip: 90048 country: United States name: Bobby Marker role: CONTACT phone: 310-423-0901 email: Robert.Marker@cshs.org name: Irina Dralyuk, MD role: PRINCIPAL_INVESTIGATOR lat: 34.05223 lon: -118.24368 hasResults: False
nctId: NCT06321458 id: LightWAY briefTitle: Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity acronym: LightWAY overallStatus: RECRUITING date: 2024-04 date: 2027-12 date: 2048-12 date: 2024-03-20 date: 2024-04-25 name: Carsten Dirksen class: OTHER name: University of Copenhagen name: University of Southern Denmark name: University of Oxford name: University of Bristol name: Copenhagen Trial Unit, Center for Clinical Intervention Research briefSummary: In this trial, the aim is to assess the clinical benefits and harms, as well as cost-effectiveness of an intensive weight loss (IWL) intervention that includes total dietary replacements, behavioural support and weight-loss medication compared with existing weight management programmes within primary care for people with severe and complex obesity. conditions: Obesity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Due to the nature of the interventions, it will not be possible to blind the participants or the healthcare providers administering the interventions. In all other aspects of the trial, blinding will be employed. Outcome assessors will be blinded to group allocation. Participants will also be requested not to disclose their allocation when outcomes are assessed.
nctId: NCT06321445 id: ChatGptASAscore briefTitle: The Success of ChatGPT in Providing American Society of Anesthesiologist (ASA) Scores acronym: ASA overallStatus: RECRUITING date: 2024-02-08 date: 2024-04-01 date: 2024-05-01 date: 2024-03-20 date: 2024-03-22 name: Kanuni Sultan Suleyman Training and Research Hospital class: OTHER briefSummary: Patients applied to the anesthesia clinics of Health Science University Istanbul Kanuni Sultan Suleyman Training and Research Hospital and Basaksehir Cam and Sakura City Hospital were included in the study. Evaluation forms which will be filled in every preoperative examinations will be saved in the hospitals systems. Patients datas without indentification informations will be asked to ChatGpt to give anesthesiological risc scores. This scores will be compared with the scores already given by anesthesiologists. conditions: Artificial Intelligence conditions: Preoperative Evaluation studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 2000 type: ESTIMATED name: providing ASA score measure: The Success of ChatGPT in Providing American Society of Anesthesiologist (ASA) Scores measure: The Success of ChatGPT in clinical decisions sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital status: RECRUITING city: Istanbul zip: 34303 country: Turkey name: Engin ihsan Turan role: CONTACT phone: 05382431114 email: enginihsan@hotmail.com lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06321432 id: LightCARE briefTitle: Intensive Weight Loss Intervention Versus Usual Care for Adults With Obesity acronym: LightCARE overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-12 date: 2048-12 date: 2024-03-20 date: 2024-04-26 name: Carsten Dirksen class: OTHER name: University of Copenhagen name: University of Southern Denmark name: University of Oxford name: University of Bristol name: Copenhagen Trial Unit, Center for Clinical Intervention Research briefSummary: In this trial, the aim is to assess the clinical benefits and harms, as well as cost-effectiveness of an intensive weight loss (IWL) intervention that includes total dietary replacements, behavioural support and weight-loss medication compared with existing weight management programmes within primary care for people with obesity class I or uncomplicated obesity class II or higher. conditions: Obesity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Due to the nature of the interventions, it will not be possible to blind the participants or the healthcare providers administering the interventions. In all other aspects of the trial, blinding will be employed. Outcome assessors will be blinded to group allocation. Participants will also be requested not to disclose their allocation when outcomes are assessed.
nctId: NCT06321419 id: atls-vs-standard-care briefTitle: ATLS vs Standard Care Trial overallStatus: NOT_YET_RECRUITING date: 2024-10 date: 2029-11 date: 2029-11 date: 2024-03-20 date: 2024-04-25 name: Karolinska Institutet class: OTHER name: The George Institute for Global Health, India briefSummary: Rationale:
The study will use an opt-out consent approach for in-hospital collection of routinely recorded data, in which consent is presumed unless actively declined. Informed consent for non-routinely recorded data including out of hospital follow up will be obtained. Patients who are unconscious or lack a legally authorized representative will be included under a waiver of informed consent. Note that consent here refers to consent to data collection, as it will not be possible for patients to opt out from being subjected to the intervention. This approach is justified because the trial can be considered to involve only minimal risk and the data collection is non-invasive and mostly involve extracting routinely collected data from medical records.
This trial is not yet fully funded. The Trial Management Group has decided to proceed with the trial with the expectation that additional funding will be secured. The Joint Trial Steering and Data Monitoring Committee will be informed of the funding status at each meeting. If funding is not secured, the trial will be stopped. This will likely result in an underpowered trial. The justification for this decision is that the intervention is considered standard of care in many countries and the data collection is considered minimal risk. There is therefore a very small risk of harm to patient participants, but a potential direct benefit to those. conditions: Wounds and Injuries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Batched stepped-wedge cluster randomised trial. We will roll out the interventions to 30 clusters over six batches, so there will be five clusters in each batch. The clusters in each batch will be randomised to one of five implementation sequences, with one hospital randomised to each implementation sequence. All clusters will transition through three phases, first a standard care phase, then a one month transition phase during which the training is delivered, and finally an intervention phase, for a total of 13 months. primaryPurpose: TREATMENT masking: NONE count: 4320 type: ESTIMATED name: Advanced Trauma Life Support training measure: All-cause mortality within 30 days of arrival at the emergency department. sex: ALL minimumAge: 15 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06321406 id: KayseriCHdysphagia briefTitle: Effect of Superficial Neuromuscular Stimulation in Post-stroke Dysphagic Patients. overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-06-15 date: 2024-07-15 date: 2024-03-20 date: 2024-03-27 name: Kayseri City Hospital class: OTHER_GOV briefSummary: Swallowing disorder in stroke patients is a significant cause of morbidity and mortality as it can cause aspiration pneumonia. Electrical stimulation has proven to be effective in post-stroke dysphagic patients.10 patients who have symptoms of post-stroke dysphagia, meet the inclusion criteria and volunteer to participate will be included in the study. Included patients will be randomized into 2 groups. The exercise program will be applied to both groups as a home program for 4 weeks. conditions: Dysphagia conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: NMES (neuromuscular electrical stimulation) name: Exercise measure: Ultrasonographic measurements measure: Functional Oral Intake Scale (FOIS) measure: Swallowing Function Screening Test (EAT-10) measure: GUSS (Gagging Swallowing Screening Test) measure: Modified Mann Swallowing Ability Assessment Test (MMASA) measure: SWAL-QOL (The impact of swallowing disorders on quality of life questionnaire) sex: ALL minimumAge: 40 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: health sciences university Kayseri medicine faculty city: Kayseri zip: 38080 country: Turkey lat: 38.73222 lon: 35.48528 hasResults: False
nctId: NCT06321393 id: HE662176 briefTitle: Effects of a CSE With ADIM in Chronic Non-specific Low Back Pain With Lumbar Instability Using Telerehabilitation. overallStatus: RECRUITING date: 2024-02-01 date: 2024-10-31 date: 2024-12-31 date: 2024-03-20 date: 2024-04-02 name: Khon Kaen University class: OTHER briefSummary: The goal of this clinical trial is to compare the effectiveness of telerehabilitation-based and clinic-based methods to deliver a Core Stabilization Exercise Program with the Abdominal Drawing-In Maneuver Technique (CSE with ADIM) on pain intensity, functional ability, quality of life, and satisfaction in chronic low back pain patients with lumbar instability.
Participants will perform a 7-week core stabilization exercise with the abdominal drawing-in maneuver technique, consisting of an exercise program for 20-minute sessions with 3 sessions per week. These exercise programs will be provided to the participants via a weekly video call with the main researcher as a telerehabilitation program. At the first session of each week, the researcher will provide supervision via video call with the participant for the exercise program. The participants will perform the exercise by following the video demonstration. After completing weekly training, participants will perform their exercise routine as part of their daily home program.
If there is a comparison group: researchers will compare The control group (clinical-base group) will be provided the 7-week core stabilization exercise with abdominal drawing-in maneuver technique, the same as the experimental group, but control groups received the exercise program at the clinic according to the usual methods. At the first session of each week, an appointment will be set, and then the specific exercise for each week will be delivered and trained by the main researcher at the clinic. After completing weekly training, participants will perform their exercise routine as part of their daily home program to see if there are any differences in pain intensity, functional ability, quality of life, and satisfaction in chronic low back pain patients with lumbar instability between the experimental and control groups. conditions: Chronic Low-back Pain conditions: Lumbar Instability studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 30 type: ESTIMATED name: 7-week Core stabilization exercise with abdominal drawing-in maneuver technique measure: 11-ponits Numerical Rating Scale (0-10 NRS) measure: Oswestry disability index (ODI) measure: Roland Morris Disability Questionnaire (RMDQ) measure: 36-item Short Form Survey (SF-36) measure: Lumbar joint reposition sense error measure: Satisfaction questionnaire sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Miss Chutimon Kongsa status: RECRUITING city: Maha Sarakham state: Mahasarakham zip: 44000 country: Thailand name: Chutimon Kongsa role: CONTACT phone: +66852736773 email: chutimon.ko@kkumail.com name: Torkamol Hunsawong role: CONTACT phone: 043202399 email: tkmhun@kku.ac.th lat: 16.18483 lon: 103.30067 hasResults: False
nctId: NCT06321380 id: 38RC23.0381 briefTitle: Working Memory Functioning in Alzheimer's Disease and Vascular Dementia acronym: MEMTRAV-COG overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-09 date: 2025-10 date: 2024-03-20 date: 2024-03-20 name: University Hospital, Grenoble class: OTHER name: University Grenoble Alps name: Université Savoie Mont Blanc name: Centre National de la Recherche Scientifique, France name: Laboratoire de Psychologie et NeuroCognition briefSummary: The aim of the present study is to investigate potential cognitive mechanisms contributing to working memory impairment in Alzheimer's disease and vascular dementia. The investigators consider a new hypothesis suggesting that difficulties in mobilizing maintenance strategies of information could explain this working memory deficit. More specifically, the investigators assume that patient groups will have difficulties in employing both refreshing and elaborative strategies during a working memory task (i.e., complex span task), as compared to a control group. conditions: Alzheimer Disease conditions: Vascular Dementia conditions: Mixed Dementias studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 120 type: ESTIMATED name: Complex span task name: Clinical neuropsychological assessment name: Clinical neurospychological assessement measure: Memory performance in the Working memory task measure: Processing performance in the Working memory task measure: Reaction time measure: Mini-Mental State Examination (MMSE) measure: Digit span forward WAIS IV (digit number) measure: Digit span forward WAIS IV (standard note) measure: Digit span backward WAIS IV (digit number) measure: Digit span backward WAIS IV (standard note) measure: Stroop Test - denomination part measure: Stroop Test - minor interference part (Time) measure: Stroop Test - minor interference part (errors) measure: Stroop Test - major interference part (time) measure: Stroop Test - major interference part (errors) measure: Trail Making Test - Part A (time) measure: Trail Making Test - Part A (errors) measure: Trail Making Test - Part B (time) measure: Trail Making Test - Part B (errors) measure: Category fluences measure: Memory evaluation (16-item Free and Cued Recall, or GERIA-12) measure: Naming task measure: Behavior rating inventory of executive function measure: Instrumental Activities of Daily Living measure: Activities of Daily Living sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT hasResults: False
nctId: NCT06321367 id: 202401002 id: 82070613 type: OTHER_GRANT domain: the National Natural Sciences Foundation of China id: 82370638 type: OTHER_GRANT domain: the National Natural Sciences Foundation of China id: 2022RC1212 type: OTHER_GRANT domain: the Science and Technology Innovation Program of Hunan Province id: 2023JJ10095 type: OTHER_GRANT domain: he Natural Science Foundation of Hunan Province China briefTitle: Model to Predict Coinfection in Elderly Patients With COVID-19 overallStatus: COMPLETED date: 2022-12-20 date: 2023-06-30 date: 2023-06-30 date: 2024-03-20 date: 2024-03-21 name: Xiangya Hospital of Central South University class: OTHER briefSummary: The goal of this observational study is to learn about the clinical characteristics and construction of a predictive model in elderly COVID-19 patients. The main question it aims to answer is the main clinical characteristics and risk factors of elderly COVID-19 patients. Participants will not be asked to do any other intervening measure. conditions: Covid19 studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ACTUAL measure: Coinfection sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Xiangya Hospital of Central South University city: Changsha state: Hunan zip: 410000 country: China lat: 28.19874 lon: 112.97087 hasResults: False
nctId: NCT06321354 id: KY 2018-066-02-3 briefTitle: Pre-emptive Infiltration of the Scalp With Diprospan Plus Ropivacaine for Pain After Craniotomy in Children overallStatus: RECRUITING date: 2024-03-20 date: 2024-10-18 date: 2024-11-02 date: 2024-03-20 date: 2024-04-02 name: Beijing Tiantan Hospital class: OTHER name: Beijing Children's Hospital briefSummary: At present, pediatric postoperative analgesia has not been fully understood and controlled, particularly craniotomy surgery. On the one hand, professional evaluation of postoperative pain for young children is difficult; on the other hand, the particularity of craniotomy adds (such as consciousness obstacle, sleepiness, et al) disturbance to the pain assessment in children. Although opioids administration is regarded as the first-line analgesic for post-craniotomy pain management, it may be associated with delayed awakening, respiratory depression, hypercarbia and it may interfere with the neurologic examination. For the avoidance of side-effects of systemic opioids, local anesthetics administered around the incision have been performed clinically. However, some studies revealed that the analgesic effect of local anesthetics was unsatisfactory due to its short pain relief duration, steroid as adjuvant can enhance postoperative analgesia and prolong postoperative analgesia time. As is reported that postoperative pain of craniotomy is mainly caused by skin incision and reflection of muscles, preventing the liberation of inflammatory mediators around the incision seems to be more effective than simply blocking nerve conduction. Researchers have clarified that the addition of diprospan to local infiltration of analgesia could provide significant analgesic effects and significantly prolong the duration of analgesic effects without obvious complications for various types of surgeries. To date, no studies have evaluated the addition of diprospan to local infiltration for patients receiving craniotomy.
Thus, investigators suppose that pre-emptive scalp infiltration with steroid (Diprospan) plus local anesthetic (ropivacaine) could relieve postoperative pain after craniotomy in children. conditions: Pain conditions: Postoperative Children studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 108 type: ESTIMATED name: The diprospan plus ropivacaine group name: The ropivacaine group measure: modified Children's Hospital of Eastern Ontario Pain Scale (mCHEOPS) measure: modified Children's Hospital of Eastern Ontario Pain Scale (mCHEOPS) measure: The time to the first rescue analgesic measure: Patient satisfactory scale (PSS) measure: Length of stay (LOS) measure: The occurrence of postoperative nausea and vomiting (PONV) measure: Ramsay Sedation Scale (RSS) measure: The occurrence of respiratory depression measure: Heart rate measure: Mean arterial pressure measure: The total consumption of opioids during the operation measure: The total consumption of anaesthetic during the operation measure: Wound Healing Score measure: Incisional related adverse events measure: The occurrence of the Adverse events (AEs) and serious adverse events (SAEs) sex: ALL minimumAge: 2 Years maximumAge: 12 Years stdAges: CHILD facility: Beijing Children's hospital affiliated to capital medical university status: RECRUITING city: Beijing state: Beijing zip: 100045 country: China name: Ge Ming, M.D role: CONTACT phone: 010-59616408 email: geming88@126.com lat: 39.9075 lon: 116.39723 facility: Beijing Tiantan Hospital status: RECRUITING city: Beijing state: Beijing zip: 100070 country: China name: Luo Fang, M.D role: CONTACT phone: +86 13611326978 email: 13611326978@163.com lat: 39.9075 lon: 116.39723 hasResults: False