Pathologists who report the liver biopsies (to assess the primary end point of study) are blinded to treatment assignment whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: Metabolic surgery name: Incretin-Based Therapy measure: Improvement of at least 1 fibrosis stage of the Kleiner fibrosis classification and no worsening of MASH in the repeat liver biopsy. measure: MASH resolution in the repeat liver biopsy measure: MASH resolution and fibrosis improvement in the repeat liver biopsy measure: Fibrosis progression in the repeat liver biopsy measure: Average Weight loss percentage measure: Disease-specific Quality of Life (QoL) measure: MASLD-related histopathologic end points measure: MASLD-related laboratory end points measure: MASLD-related liver scan end points measure: MASLD-related clinical end points measure: Achieved Weight-loss proportions measure: Weight change (kg) measure: BMI change (kg/m^2) measure: Excess weight loss, % measure: Change in waist circumference, cm measure: Systolic blood pressure trends, mmHg measure: Mean and change from baseline in lipid panel, mg/dl measure: Changes in glucose hemostasis markers measure: Percentage of patients with T2DM meeting predefined HbA1c targets measure: Changes in inflammatory markers, CRP mg/L measure: Change in cardiovascular and diabetes medications measure: SF-Bari Score measure: Quality of life end points measure: Safety end points sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Banner Health Center city: Phoenix state: Arizona zip: 85006 country: United States name: Farah Husain, MD role: CONTACT email: Farah.husain@bannerhealth.com lat: 33.44838 lon: -112.07404 facility: Indiana University city: Indianapolis state: Indiana zip: 46202 country: United States name: Dimitrios Stefanidis, MD, PhD role: CONTACT email: dstefanidis@iuhealth.org lat: 39.76838 lon: -86.15804 facility: Mayo Clinic city: Rochester state: Minnesota zip: 55905 country: United States name: Omar Ghanem, MD role: CONTACT email: ghanem.omar@mayo.edu lat: 44.02163 lon: -92.4699 facility: Cleveland Clinic city: Cleveland state: Ohio zip: 44195 country: United States name: Ali Aminian, MD role: CONTACT email: aminiaa@ccf.org lat: 41.4995 lon: -81.69541 facility: Hospital Alemão Oswaldo Cruz city: São Paulo country: Brazil name: Ricardo Cohen, MD role: CONTACT email: ricardo.cohen@haoc.com.br lat: -23.5475 lon: -46.63611 facility: McGill University city: Montréal country: Canada name: Amin Andalib, MDCM, MSc role: CONTACT email: amin.andalib@mcgill.ca lat: 45.50884 lon: -73.58781 facility: Turku University Hospital city: Turku country: Finland name: Paulina Salminen, MD, PhD role: CONTACT email: paulina.salminen@tyks.fi lat: 60.45148 lon: 22.26869 facility: Sri Aurobindo Institute of Medical Sciences city: Indore country: India lat: 22.71792 lon: 75.8333 facility: The Digestive Health Institute city: Mumbai country: India lat: 19.07283 lon: 72.88261 facility: University College Dublin city: Dublin country: Ireland name: Helen Heneghan, MB BCh BAO, PhD role: CONTACT email: helen.heneghan@ucd.ie lat: 53.33306 lon: -6.24889 facility: Università Cattolica del Sacro Cuore city: Milan country: Italy name: Geltrude Mingrone, M.D. PhD role: CONTACT email: geltrude.mingrone@unicatt.it lat: 45.46427 lon: 9.18951 facility: Sapienza Università di Roma city: Roma country: Italy name: Giovanni Casella, MD role: CONTACT email: giovanni.casella@uniroma1.it lat: 41.89193 lon: 12.51133 facility: Kuwait University city: Kuwait country: Kuwait lat: 29.36972 lon: 47.97833 facility: Instituto Nacional de Ciencias Médicas y Nutrición Salvador city: Mexico City country: Mexico name: Mauricio Sierra, MD role: CONTACT lat: 19.42847 lon: -99.12766 facility: Hospital Clínic Barcelona city: Barcelona country: Spain lat: 41.38879 lon: 2.15899 facility: Linköping University city: Linköping country: Sweden lat: 58.41086 lon: 15.62157 facility: Örebro University city: Örebro country: Sweden name: Erik Stenberg, MD, PhD role: CONTACT email: erik.stenberg@regionorebrolan.se lat: 59.27412 lon: 15.2066 facility: Clarunis Universitäres city: Basel country: Switzerland name: Ralph Peterli, Dr. med role: CONTACT email: ralph.peterli@clarunis.ch lat: 47.55839 lon: 7.57327 facility: Hôpitaux universitaires de Genève city: Geneva country: Switzerland name: Minoa Jung, PD Dr. med. role: CONTACT email: minoa.jung@hcuge.ch lat: 46.20222 lon: 6.14569 facility: Nuffield Health Bristol Hospital city: Bristol country: United Kingdom name: Dimitri Pournaras, PhD role: CONTACT email: dpournaras@doctors.org.uk lat: 51.45523 lon: -2.59665 facility: King's College Hospital city: London country: United Kingdom name: Francesco Rubino, MD role: CONTACT email: francesco.rubino@kcl.ac.uk lat: 51.50853 lon: -0.12574 facility: Queen Mary University city: London country: United Kingdom name: William Alazawi, MB BChir PhD role: CONTACT email: w.alazawi@qmul.ac.uk lat: 51.50853 lon: -0.12574 hasResults: False