nctId: NCT06316778 id: 2023-038 briefTitle: Pelvic Floor Muscle Training for Women With Myotonic Dystrophy overallStatus: ENROLLING_BY_INVITATION date: 2024-03-11 date: 2024-12-01 date: 2024-12-01 date: 2024-03-18 date: 2024-03-28 name: Université de Sherbrooke class: OTHER name: Centre de recherche du Centre hospitalier universitaire de Sherbrooke name: Interdisciplinary research team on neuromuscular diseases (GRIMN) name: CIUSSS Saguenay-Lac-Saint-Jean briefSummary: Myotonic dystrophy type 1 (DM1) is a neuromuscular disease characterized by multisystem manifestations. DM1 can affect the urinary system through the impact of the pelvic floor muscles (PFM). Urinary incontinence can occur in this situation and is often offset with compensatory measures without restoring the PFM function (e.g. sanitary pads). PFM training have already been shown to be effective in reducing or even eliminating urinary incontinence in the general population. However, no study has been the subject of this modality in people with DM1. Having recently shown that it is possible to gain strength with DM1, a strengthening protocol targeting PFM could prove effective in treating urinary incontinence. The objectives of this study are i) to assess the feasibility and acceptability of PFM training and ii) to investigate the effects of PFM training in women with DM1 with adult phenotype. A quasi-experimental study will be conducted with 12 women having a confirmed diagnosis of DM1 with urinary incontinence. Participants will follow a 12-week PFM training program, comprising weekly sessions with an experienced physiotherapist as well as a home exercise program. Outcomes measures will be assessed at baseline and at post-treatment and will include: feasibility and acceptability variables, frequency of urinary incontinence, urogynecological symptoms and their impact on quality of life, morphometry and function of PFM, and the perceived improvement following the treatments. This study has the potential to improve the management of urinary incontinence and support the implementation of pelvic floor rehabilitation services in this population. conditions: Myotonic Dystrophy Type 1 conditions: Urinary Incontinence studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: pre-treatment assessment - intervention (12 weeks) - post-treatment assessment primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: Pelvic floor muscle training measure: Percentage of attended treatment sessions measure: Percentage of home exercises performed measure: Retention rate measure: Recruitment rate measure: Intervention Acceptability Questionnaire measure: Change in the frequency of urinary incontinence episodes measure: Change in urinary incontinence symptoms measure: Change in pelvic floor disorder symptoms measure: Change in pelvic floor disorder symptoms related impact on quality of life measure: Change in pelvic floor muscles morphometry measure: Change in pelvic floor muscles function measure: Patient's satisfaction measure: Patient's global impression of change measure: Patient's estimated improvement sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clinique des maladies neuromusculaires city: Jonquière state: Quebec zip: G7X 7X2 country: Canada lat: 48.41648 lon: -71.24884 hasResults: False