hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06272656 id: AKR-TACE-001 briefTitle: Evaluation of AKR1B10 as a New Marker for Interventional Therapy of Hepatocellular Carcinoma overallStatus: RECRUITING date: 2024-04-01 date: 2025-06-30 date: 2025-06-30 date: 2024-02-22 date: 2024-04-03 name: Hebei Medical University Third Hospital class: OTHER briefSummary: Primary liver cancer is currently the fourth most common malignant tumor and the second leading cause of tumor mortality in China, posing a serious threat to the lives and health of the Chinese people . At present, non-surgical treatment methods are often used, such as radiofrequency ablation (RFA), Transcatheter arterial chemoembolization (TACE), radiation therapy, and systemic anti-tumor therapy. However, whether it is surgical treatment or non-surgical treatment, commonly used liver cancer related biomarkers in clinical practice during the evaluation of treatment efficacy or regular follow-up of patients include AFP, AFP-L3%, DCP, etc. , but there are no reports on whether AKR1B10 can be used for the efficacy evaluation of these treatment methods.Therefore, this project aims to explore the clinical value of AKR1B10 in evaluating the efficacy of liver cancer treatment. conditions: Hepatocellular Carcinoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: comparison of liver cancer markers AKR1B10, AFP, AFP-L3% and DCP before and after TACE measure: long-term survival (1-year, 3-year, 5-year) measure: progression- free - time sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: HebeiMUTH status: RECRUITING city: Shijia Zhuang state: Hebei zip: 050000 country: China name: Yuemin Nan role: CONTACT phone: +8633188602489 email: Hb20231221@163.com name: Pei Guo role: CONTACT phone: 17835683894 email: G545632518@163.com lat: 34.17775 lon: 109.84894 typeAbbrev: Prot_ICF hasProtocol: True hasSap: False hasIcf: True label: Study Protocol and Informed Consent Form date: 2023-12-25 uploadDate: 2024-02-02T21:48 filename: Prot_ICF_000.pdf size: 258859 hasResults: False
nctId: NCT06272643 id: EPIC36-EMPERATRIZ briefTitle: Comparison Between Optical Coherence Tomography and Intravascular Ultrasound for Intermediate Left Main Coronary Artery Lesions acronym: EMPERATRIZ overallStatus: RECRUITING date: 2024-04-04 date: 2025-01-20 date: 2026-01-20 date: 2024-02-22 date: 2024-04-09 name: Fundación EPIC class: OTHER briefSummary: Significant coronary disease of the left main coronary artery (LMCA) is found in 4%-5% of all coronary angiography procedures. Classically, it has been determined that a significant angiographic stenosis should reach at least 50% of the vessel diameter by visual estimation, which corresponds to 75% of the vessel area. However, angiography has a number of limitations inherent to the technique and location of stenosis, and other techniques are therefore available for evaluation. Intracoronary ultrasound (IVUS) deserves, together with the pressure guidewire, special consideration in determining the severity assessment (anatomical and functional) of lesions in this location. Using IVUS the most commonly used cut-off value is 6 mm2. in ambiguous lesions of the LMCA, a MLA \>6 mm2 would indicate no revascularisation, a MLA \<4.5-5 mm2 would indicate revascularisation, and MLA values between 4.5-5 and 6 mm2 would make it advisable to use FRF/iFR to decide. Optical coherence tomography (OCT) is another intracoronary imaging modality, with greater resolution and significant differences from IVUS. no MLA cut-off point with OCT has been demonstrated for the management of LMCA lesions. Due to the differences in imaging with both techniques, the thresholds established as cut-off points in IVUS cannot be extrapolated to OCT. The objective is to compare the minimal luminal area by IVUS and OCT of angiographically intermediate LCMA lesions and to assess the prognostic value of TCFA assessed by OCT. conditions: Coronary Disease studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 129 type: ESTIMATED name: IVUS (Intravascular Ultrasound) and OCT (Optical Coherence Tomography) measure: To assess the agreement between minimum luminal area measured by IVUS and OCT in intermediate LCMA lesions measure: Cardiac Death measure: Cardiovascular Death measure: Acute myocardial infarction of treated/functionally assessed lesion measure: Acute myocardial infarction of any lesion measure: Need for revascularisation of lesion treated/functionally assessed measure: Need for revascularisation of any lesion measure: Secondary efficacy endpoint: Clear Image Length measure: Extend of detectable EEL in LM measure: Correlation between contrast volume used and results, as well as the average contrast volume used in the study. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Universitario Juan Ramon Jimenez status: RECRUITING city: Huelva zip: 21005 country: Spain lat: 37.26638 lon: -6.94004 facility: Hospital Universitario de Leon status: RECRUITING city: León zip: 24071 country: Spain lat: 42.60003 lon: -5.57032 hasResults: False
nctId: NCT06272630 id: DW_DWJ1464401 briefTitle: Study to Evaluate the Efficacy and Safety of DWJ1464 in Patients With Chronic Liver Disease overallStatus: ENROLLING_BY_INVITATION date: 2023-02-06 date: 2024-05-31 date: 2024-08-31 date: 2024-02-22 date: 2024-04-26 name: Daewoong Pharmaceutical Co. LTD. class: INDUSTRY briefSummary: This study aims to assess the effect of DWJ1464 on improvement of liver function in patients with Chronic liver disease. Patients with Chronic liver disease aged 19 years or over will participate in the study. The study design is a multi-center double-blinded randomized placebo-controlled trial. The patients were diagnosed with Chronic liver disease based on our criteria and were randomized to either the placebo or DWJ1464 administration group. Primary endpoint was the change of ALT level after 8 weeks compared to the baseline. Secondary endpoints included the change of ALT level after 4 weeks, the change rate of ALT level after 8 weeks and improvement of fatigue, compared to the baseline. the adverse effect of DWJ1464 were also recorded. conditions: Chronic Liver Disease studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 258 type: ESTIMATED name: DWJ1464 name: Placebo of DWJ1464 measure: At 8 weeks, the change of ALT level compared to baseline measure: At 4 weeks, the change of ALT level compared to baseline measure: At 4, 8 weeks, the change of AST level compared to baseline measure: At 4, 8 weeks, the change of liver function comparator GGT level compared to baseline measure: At 8 weeks, the change of liver function comparator Fibrotest compared to baseline measure: At 8 weeks, the change of liver function comparator Fibroscan compared to baseline measure: At 4, 8 weeks, the change of K-CFQ(Korean version of Chalder Fatigue Scale) scores, compared to the baseline sex: ALL minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT facility: SoonChunHyang University Seoul Hospital city: Seoul zip: 04401 country: Korea, Republic of lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06272617 id: 2023-960 briefTitle: Acupuncture for Prevention and Treatment of Oral-related Complications Caused by Radiotherapy for Head and Neck Cancer overallStatus: RECRUITING date: 2023-07-25 date: 2024-07-24 date: 2025-07-24 date: 2024-02-22 date: 2024-02-22 name: West China Hospital class: OTHER name: West China Fourth Hospital, Sichuan University briefSummary: A study on the efficacy and safety of acupuncture for the prevention and treatment of oral-related complications caused by radiotherapy for head and neck malignant tumors conditions: Malignant Tumor of Head and/or Neck conditions: Radiotherapy; Complications studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 138 type: ESTIMATED name: verum acupuncture name: sham acupuncture measure: Xerostomia questionnaire scores measure: Salivary flow rate measure: Taste function assessed by patients measure: Taste function assessed by electrogustometer test measure: Taste function assessed by taste strips test measure: Oral mucositis measure: Dysphagia measure: Quality of Life assessed by EORTC QLQ-C30 measure: Quality of Life assessed by QLQ-H&N35 measure: Adverse effects measure: Changes of oral flora measure: Tongue range of motion measure: Neck Fibrosis sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: West China Hospital, Sichuan University status: RECRUITING city: Chengdu state: Sichuan country: China name: Xingchen Peng role: CONTACT phone: 0086-18980606753 email: pxx2014@scu.edu.cn lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06272604 id: 2024-IRB-0015-P-01 briefTitle: Exercise Rehabilitation for Children With Asthma overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-04-01 date: 2027-10-01 date: 2024-02-22 date: 2024-02-22 name: The Children's Hospital of Zhejiang University School of Medicine class: OTHER briefSummary: Asthma, a prevalent chronic condition among children and adolescents, substantially impairs their quality of life. In addressing this significant health concern, this study focuses on the potential of a customized exercise rehabilitation program tailored for this young demographic. By employing a randomized controlled trial design, the research aims to divide participants into two distinct groups: one undergoing a personalized exercise regimen and the other receiving standard medical care. The 12-week intervention for the exercise group includes a combination of aerobic activities, strength training, and targeted breathing exercises. The study's primary aim is to rigorously evaluate the impact of this specialized exercise protocol on critical health aspects such as lung function, physical endurance, frequency of asthma attacks, and overall quality of life. The anticipated findings from this research are expected to shed new light on effective asthma management strategies and offer invaluable guidance for clinical practices dedicated to improving health outcomes in young asthma patients. conditions: Asthma in Children conditions: Rehabilitation conditions: Exercise studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Personalized Exercise Rehabilitation measure: Lung Function measure: Daily Physical Activity Level measure: Asthma Control Status measure: Fractional Exhaled Nitric Oxide (FeNO) measure: Body Composition measure: Sleep measure: Health Related Quality of Life measure: Anxiety and Depression measure: Inflammatory Mediators sex: ALL minimumAge: 6 Years maximumAge: 17 Years stdAges: CHILD hasResults: False
nctId: NCT06272591 id: IRBN1192023/CHUSTE briefTitle: Comparison of Patient Satisfaction With Home Induction and In-patient Induction. overallStatus: RECRUITING date: 2023-11-20 date: 2024-05 date: 2024-05 date: 2024-02-22 date: 2024-02-22 name: Centre Hospitalier Universitaire de Saint Etienne class: OTHER briefSummary: Induced labour is a medical intervention designed to initiate or accelerate the childbirth process when clinically indicated.
Induced labour concerns 25.8% of pregnant women in France, according to the latest National Perinatal Survey 2021. This rate is rising steadily, since in 2016 induction concerned 22% of pregnancies. There are many medical indications for induction, both maternal and foetal. Induced labour in hospitals is beginning to reach its limits, given the reduction in the number of nursing staff and the reduction in the number of beds available. In some cases, patients are hospitalised for 24 to 72 hours before going into labour. In this context, the place where the birth takes place, whether at home or in hospital, is essential, with a potential impact on patient satisfaction and the experience of induction.
Cervical ripening can be a difficult experience for women, with a feeling of loss of control at this crucial stage. The duration of induction is one of the factors that women would like to see changed when asked about the aftermath of induction. The option of inducing at home might seem to improve women's experience and reduce the length of their stay in hospital. conditions: Induced; Birth conditions: Pregnancy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Preliminary search in the patient's file name: A posteriori research in the patient's file name: First questionnaire : choice of induction method reason for choice name: Second questionnaire : experience of induction measure: Questionnaire on patients' experience of induction in hospital and at home. measure: Questionnaire on patients' satisfaction of induction in hospital and at home. measure: Questionnaire on patients' choice of induction method measure: Questionnaire on reasons for choosing home induction. measure: Maternal morbidity measure: Maternal mortality measure: Neonatal morbidity measure: Neonatal mortality sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chu Saint Etienne status: RECRUITING city: St Etienne zip: 42100 country: France name: Tiphaine BARJAT, MD PhD role: CONTACT phone: (0)477828609 phoneExt: +33 email: tiphaine.barjat@chu-st-etienne.fr name: Clara CHIARADONNA, resident role: CONTACT phone: (0)634100341 phoneExt: +33 email: clara.chiaradonna@etu.univ-st-etienne.fr name: Tiphaine BARJAT, MD PhD role: PRINCIPAL_INVESTIGATOR name: Clara CHIARADONNA, resident role: SUB_INVESTIGATOR lat: 45.43389 lon: 4.39 hasResults: False
nctId: NCT06272578 id: 20021405 briefTitle: Screen CardRen - A Cross-sectional Observational Cohort Study overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-02-27 date: 2025-06-30 date: 2024-02-22 date: 2024-02-23 name: Charite University, Berlin, Germany class: OTHER name: AstraZeneca briefSummary: In this single-centre, cross-sectional study, the investigators aim to assess the prevalence of asymptomatic echocardiographic structural and functional cardiac abnormalities in adult CKD patients with additional cardiovascular risk factors. Furthermore, with the use of Olink technology, analyses of the plasma proteome will be performed to identify potential protein pathways associated with early structural changes.The investigators hypothesize that protein expression will be altered in patients with prevalent echocardiographic abnormalities that indicate stage B heart failure. conditions: Heart Failure conditions: Chronic Kidney Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 400 type: ESTIMATED name: Echocardiography measure: prevalence of significant asymptomatic cardiac structural abnormalities and cardiac dysfunction measure: Proteomic analysis measure: Duration of echocardiographic examination measure: Time saved by portable echocardiography and automated image analysis measure: Image quality of cart-based vs. portable echo images sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06272565 id: 2023KYPJ292 briefTitle: Exploring the Interaction Between Metabolic Disorders and NLPR3 Inflammasome Activation in DR Inflammatory Damage acronym: DR overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-12-30 date: 2026-12-30 date: 2024-02-22 date: 2024-02-22 name: Zhongshan Ophthalmic Center, Sun Yat-sen University class: OTHER briefSummary: Diabetic retinopathy (DR) is one of the most serious microvascular complications of diabetes. Early diagnosis and treatment of diabetes is the key to prevent visual impairment in DR patients. This study aims to use a non-targeted metabolomics detection technique combined with ultra-high performance liquid chromatography time-of-flight mass spectrometry to analyze the metabolomics profile in aqueous humor sample of DR patents, and further explore the mechanism of the relationship between differential metabolites and their metabolic pathways with NLRP3 activation in DR inflammatory damage. DR patients with macular edema will receive anti-vascular endothelial growth factor (anti-VEGF) treatment; these patients will be divided into two groups: responders group and non-responders group. conditions: Diabetic Retinopathy conditions: Diabetic Macular Edema conditions: Anti-vascular Endothelial Growth Factor studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 240 type: ESTIMATED measure: Untargeted metabolomics for metabolic profile using UHPLC/MS measure: Best-corrected visual acuity measure: Central subfield thickness sex: ALL minimumAge: 40 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Zhongshan Ophthalmic Center of Sun Yat-sen University city: Guangzhou state: Guangdong zip: 510623 country: China name: Zhongshan Ophthalmic Center of Sun Yat-sen University role: CONTACT phone: 86+13560323773 email: chh5413@126.com lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06272552 id: PI21-00026 id: 2021/10182/I type: OTHER domain: CEIm Parc de Salut Mar briefTitle: Implementing PROMs and PREMs in Routine Clinical Care: Assessment of Requirements and Impact acronym: PROMs & PREMs overallStatus: RECRUITING date: 2023-10-25 date: 2027-10 date: 2027-10 date: 2024-02-22 date: 2024-02-22 name: Parc de Salut Mar class: OTHER name: Instituto de Salud Carlos III briefSummary: There has been increasing interest in the use of patient-reported outcomes and experience measures (PROMs and PREMs) in clinical practice; yet few empirical studies have been conducted to evaluate the usefulness of such implementation.
Expected results: Incorporating PROMs and PREMs in routine clinical care may improve patients\' and health professionals\' experiences on health care, as well as improve patients\' health. conditions: PROMs conditions: PREMs conditions: Implementation Research conditions: Impact Evaluation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 1440 type: ESTIMATED name: PROMs and PREMs name: PREMs name: Control name: Healthcare professionals measure: Evaluation quesionnaire (PRMIAT) of the implementation to be completed by all patients and healthcare professionals measure: Health-related quality of life sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital del Mar Reseach Institute status: RECRUITING city: Barcelona state: Catalonia zip: 08003 country: Spain name: Olatz Garin role: CONTACT phone: +34 636210255 email: ogarin@research.net name: Olatz Garin role: PRINCIPAL_INVESTIGATOR lat: 41.38879 lon: 2.15899 hasResults: False
nctId: NCT06272526 id: SOCIALANX_1 briefTitle: Internet-Based Self-Help Intervention for Social Anxiety Symptoms overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-10-01 date: 2024-12-31 date: 2024-02-22 date: 2024-02-22 name: Anadolu University class: OTHER briefSummary: This study is a randomized-controlled trial in which the assumed superiority of the module internet-based cognitive behavioral therapy intervention for social anxiety disorder is evaluated compared to a waitlist control group. Participants will be assigned to one of two groups, treatment which have web-based intervention (guided), and waitlist.
The intervention program will be offered to treatment group participants (guided) through the website https://kendikendineyardim.org, the unique online self-help platform in Turkey. Participants in the web-based treatment group will receive feedback message within 24 hours after each completed module from the guides. conditions: Mental Health Issue studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 30 type: ESTIMATED name: Internet Based Intervention - GUIDED measure: Liebowitz Social Anxiety Scale (LSAS) Turkish Form measure: Social Appearance Anxiety Scale (SAAS) Turkish Form measure: Patient Health Questionnaire-9 (PHQ-9) Turkish Form measure: Generalized Anxiety Disorder-7 (GAD-7) Turkish Form measure: Sociodemographic Information Form measure: System Usability Scale (SUS-10) Turkish Form measure: Attitudes Toward Internet-Based Interventions Scale (ETAM) Turkish Form measure: Adherence to Intervention measure: Guide Evaluation sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06272513 id: ProAct-HNC-02 briefTitle: Influencing Factors for Physical Activity in People With Head and Neck Cancer acronym: ProAct-HNC overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-03-31 date: 2025-06-30 date: 2024-02-22 date: 2024-02-26 name: Kantonsspital Winterthur KSW class: OTHER name: Eastern Switzerland University of Applied Sciences name: University of Applied Sciences of Western Switzerland name: UMC Utrecht name: University of Lausanne name: Zurich University of Applied Sciences briefSummary: The goal of this qualitative study is to explore influencing factors for physical activity participation in people affected by an advanced head and neck cancer from the perspective of people affected and their significant others.
The interviews will be transcribed verbatim and analysed with a structuring content analysis approach. conditions: Advanced Head and Neck Squamous Cell Carcinoma studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 20 type: ESTIMATED measure: interview transcripts measure: personal information of participants sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2024-02-09 uploadDate: 2024-02-15T04:21 filename: Prot_000.pdf size: 1702659 hasResults: False
nctId: NCT06272500 id: 2024-KY-0146-001 briefTitle: Exploring Methods for Treating Hypergastrinemia in Patients With Autoimmune Gastritis overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-05-31 date: 2024-05-31 date: 2024-02-22 date: 2024-02-22 name: Jianning Yao class: OTHER briefSummary: Autoimmune atrophic gastritis (AAG) is an organ-specific autoimmune disease that primarily affects the gastric body and fundus while sparing the antrum. Its characteristics include destruction of gastric wall cells, loss of intrinsic factors, and atrophy of the gastric mucosa. Endoscopic examination reveals features of reverse atrophy, with significant atrophy in the gastric body and fundus, appearing as a mosaic of red and white patches. Currently, AAG is believed to result from a pathological CD4+ T-cell-mediated autoimmune response against the gastric H+/K+-ATPase. CD4+ T lymphocytes target the parietal cells' H+/K+-ATPase, stimulating plasma cells to secrete autoantibodies, including parietal cell antibodies (PCA) and intrinsic factor antibodies (IFA). The former plays a key role in parietal cell destruction and glandular atrophy. AAG is considered a premalignant condition, with the potential development of gastric dysplasia, cancer, and type 1 gastric neuroendocrine tumours (type 1 g-NET).
Gastric neuroendocrine tumors (g-NETs), also known as gastric carcinoids, account for approximately 23% of gastrointestinal and pancreatic neuroendocrine tumors. Clinically, g-NETs are mainly classified into three types. Type III is typically sporadic tumors associated with normal gastrin levels and poor prognosis. Although type 1 g-NETs caused by AAG are usually well-differentiated, studies have reported that 8%-23% of type 1 g-NETs extending into the deep submucosal layer may metastasize to regional lymph nodes or even to the liver. Furthermore, 3% of patients may develop neuroendocrine carcinoma, highlighting the need for appropriate attention.