hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06337877 id: pEEG ARDS briefTitle: Assessment of Sedation Depth in ARDS Patients Undergoing Therapeutic Paralysis overallStatus: ACTIVE_NOT_RECRUITING date: 2023-10-01 date: 2024-04-17 date: 2024-04-24 date: 2024-03-29 date: 2024-03-29 name: Tepecik Training and Research Hospital class: OTHER briefSummary: "In intensive care units, therapeutic paralysis has been a routine treatment method for many years in a select group of patients. Sufficient and appropriate sedation in patients undergoing therapeutic paralysis is crucial to prevent awareness and reduce the risk of excessive sedation. Both inadequate and excessive sedation levels can be highly detrimental to the patient. Clinical assessment may not always provide accurate information regarding sedation depth. Recently, the frequency and workload of therapeutic paralysis treatment in intensive care units have increased due to COVID-19 pneumonia. Therefore, the investigators believe that inadequate sedation may be common in these patients. Processed electroencephalogram parameters such as bispectral index or patient state index (PSI), routinely used in operating rooms and intensive care units, are commonly used to indicate sedation depth. In this study, the investigators aimed to determine sedation levels in patients during paralysis, assess the prevalence of inadequate or excessive sedation, and observe the doses of sedatives and analgesics used." conditions: Sedation Complication conditions: Acute Respiratory Distress Syndrome Due to COVID-19 conditions: Anesthesia Awareness studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 52 type: ACTUAL name: Depth of sedation monitoring measure: To determine the sedation levels of patients during paralysis measure: The prevalence of inadequate or excessive sedation, measure: Evaluation of Concordance Between Richmond Agitation-Sedation Scale (RASS), sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Aykut Saritaş city: İ̇zmi̇r zip: 35640 country: Turkey lat: 38.41273 lon: 27.13838 hasResults: False
nctId: NCT06337864 id: H-24017055 briefTitle: Evaluating the Efficacy and Safety of Large Neutral Amino Acids in the Treatment of Classical Phenylketonuria overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-12 date: 2027-12 date: 2024-03-29 date: 2024-03-29 name: Rigshospitalet, Denmark class: OTHER briefSummary: This research investigates the effectiveness and safety of large neutral amino acid (LNAA) supplementation in patients with classical phenylketonuria (PKU). Advanced brain imaging techniques alongside comprehensive neuropsychological and functional assessments will be employed. Short-term and long-term follow-up of participants will be conducted. conditions: Brain Diseases conditions: Brain Diseases, Metabolic conditions: Brain Diseases, Metabolic, Inborn conditions: Genetic Diseases, Inborn conditions: Metabolism, Inborn Errors conditions: Amino Acid Metabolism, Inborn Errors conditions: Metabolic Disease conditions: Phenylketonurias studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: To fully assess the effectiveness of LNAA, the following trials will be conducted:
4. Healthy control group primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: PreKUnil® LNAA Medical Food for PKU measure: Dynamic positron emission tomography (PET) imaging with the fluorine-18-labeled tracer [18F]-(E)-N-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4'-methyl phenyl)nortropane ([18F]FE-PE2I) measure: Computerized neuropsychological testing (responses over study iPad) measure: Behaviour Rating Inventory of Executive Function - Adult version (BRIEF-A) measure: Behaviour Rating Inventory of Executive Function - Second edition (BRIEF-2) measure: Adult attention deficit hyperactivity disorder (ADHD) Self-Report Scale (ASRS v1.1) measure: Adolescent ADHD Self-Report Scale measure: PKU-QOL Questionnaire Adolescent or Adult version measure: Symptom Checklist-90-Revised (SCL-90-R) measure: Behavior Assessment System for Children, Third Edition (BASC-3) measure: Neuropsychological testing of flexibility and verbal fluency measure: Urine peripheral biomarkers of neurotransmitters measure: Incidence and severity of treatment-emergent adverse events (TEAEs) measure: Fasting plasma amino acids, dried blood spots (finger-prick method) measure: Brain perfusion measures measure: Adherence to dietary treatment measure: Brain Magnetic Resonance Imaging (MRI) measure: Wechsler Adult Intelligence Scale (WAIS) - IV sex: ALL minimumAge: 16 Years maximumAge: 50 Years stdAges: CHILD stdAges: ADULT facility: Copenhagen University Hospital, Rigshospitalet city: Copenhagen country: Denmark name: Olivia Welle Fjellbirkeland, MD role: CONTACT email: olivia.welle.fjellbirkeland@regionh.dk lat: 55.67594 lon: 12.56553 hasResults: False
nctId: NCT06337851 id: AtaturkTRH2003/9 briefTitle: Comparing Simultaneous and Consecutive Drainage of Bilateral Chronic Subdural Hematoma overallStatus: COMPLETED date: 2003-11 date: 2010-04 date: 2011-04 date: 2024-03-29 date: 2024-03-29 name: Ataturk Training and Research Hospital class: OTHER briefSummary: Surgical evacuation CSDH via burr hole craniostomy appears to be the most widely practiced treatment technique worldwide and outcomes are generally favorable.
In previous reports, bilateral CSDH was raised as a predictor of rapid deterioration and worse outcomes attributable to brain herniation, in comparison with unilateral ones. Nevertheless, the optimal surgical considerations in bilateral CSDH still remain controversial. Thus, this study principally aims to finding out whether consecutive removal of bilateral CSDH really poses a complication risk. The secondary objectives of the study were to obtain information about the one-year prognosis of bilateral CSDH and to find factors that affect the prognosis, if any.
Operation Patients in group-1 were fixed in supine position with their heads in neutral and flexion position. Bilateral burr holes were made one after another, the dural surfaces were exposed at the same time, then the outer membranes of both sides opened and hematomas evacuated simultaneously. All the patients underwent a drainage system, performed with the insertion of a silicone tube into the subdural space and tunneled under the scalp to the exit point. In group-2, hematoma with a greater thickness was removed first (if thickness was equal on both sides, first incision was made on the right side). The head in supine position was rotated to the side with a smaller hemorrhage thickness. Previously, burr holes were made, the dural surfaces were exposed, the outer membrane opened, and the hematoma was evacuated at one side. Then, drainage system inserted into the subdural space. After the procedure of the first side was completed, as a consecutive process, the head was rotated to the other side, and the same procedure was repeated. The contralateral hematoma was evacuated.
This evaluation protocol will be executed immediately following the surgical procedure, after the removal of surgical drains (usually on the second postoperative day), and at designated intervals of the 1st, 3rd, 6th, and 12th months to monitor patient progress and recovery. conditions: Subdural Hematoma, Chronic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: a prospective randomized controlled trial primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 43 type: ACTUAL name: Simultaneous burr hole craniostomy name: Consecutive burr hole craniostomy measure: The Primary Outcome: Mortality measure: The Primary Outcome: Early Postoperative Success Rate (Redo Surgery) measure: The secondary outcome: Follow-up assessment (Age) measure: The secondary outcome: Follow-up assessment (Sex) measure: The secondary outcome: Follow-up assessment (Trauma-Relation) measure: The secondary outcome: Follow-up assessment (Concomitant Pathologies) measure: The secondary outcome: Follow-up assessment (The Glasgow Coma Scale) measure: The secondary outcome: Follow-up assessment (The Markwalder Grading Scale) measure: The secondary outcome: Follow-up assessment (Neurological Examination - Motor) measure: The secondary outcome: Follow-up assessment (Neurological Examination - fundus oculi) measure: The secondary outcome: Follow-up assessment (Neurological Examination - babinski sign) measure: The secondary outcome: Follow-up assessment (Radiological Assessments - midline shift) measure: The secondary outcome: Follow-up assessment (Radiological Assessments - hematoma volum) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Izmir Ataturk Training and Research Hospital city: Izmir zip: 35360 country: Turkey lat: 38.41273 lon: 27.13838 hasResults: False
nctId: NCT06337825 id: 22-727 briefTitle: Object Assessment of Improvement in Non-Specific Symptoms After Parathyroidectomy for Primary Hyperparathyroidism overallStatus: ACTIVE_NOT_RECRUITING date: 2022-07-19 date: 2024-03-12 date: 2024-06-29 date: 2024-03-29 date: 2024-04-15 name: The Cleveland Clinic class: OTHER briefSummary: Wearable electronic devices are becoming more prevalent in daily life, as they offer real time information on physiological parameters such as heart rate, activity level, oxygenation, and sleep patterns for their users. These wearable electronic devices are easy to install and offer no major risk or discomfort to the user. Implementation of these technologies into medicine has exponentially grown in the past decade with supporting evidence for their use in cardiovascular disease and sleep medicine. The investigators believe that these devices will be able to capture the changes associated with improvement in non-specific symptoms that have not been previously demonstrated. conditions: Primary Hyperparathyroidism conditions: Multinodular Goiter studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 80 type: ESTIMATED name: Activity Tracker (Fitbit) name: HbA1C name: The PROMPT Questionnaire measure: Change in resting heart rate over time among study participants as monitored by fitness tracker measure: Change in number of awakenings during sleep over time among study participants as monitored by fitness tracker measure: Change in % Deep Sleep over Total Sleep Minutes over time among study participants as monitored by fitness tracker measure: Change in steps over time among study participants as monitored by fitness tracker measure: Change in total active minutes over time among study participants as monitored by fitness tracker measure: Change in% Active Calorie over Total Calories over time among study participants as monitored by fitness tracker measure: Change in glucose levels (HbA1C) measure: Correlation of Quality of Life surveys with the PROMPT survey sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Cleveland Clinic Foundation city: Cleveland state: Ohio zip: 44195 country: United States lat: 41.4995 lon: -81.69541 hasResults: False
nctId: NCT06337812 id: HUM00240473 briefTitle: Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF) overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-06 date: 2025-06 date: 2024-03-29 date: 2024-03-29 name: University of Michigan class: OTHER briefSummary: The study team is studying how increasing dietary fiber, specifically through adding potato starch to participant's diet, may impact the species of bacteria in participant's gut microbiome. The study team also wants to understand if adding potato starch to participant's diet helps these bacteria make more short chain fatty acids, a byproduct the team thinks may benefit participant's health. conditions: Type2diabetes conditions: Heart Failure With Preserved Ejection Fraction studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 30 type: ESTIMATED name: Potato Starch measure: Changes in Short Chain Fatty Acid (SCFA) butyrate levels - stool measure: Changes in Short Chain Fatty Acid (SCFA) butyrate levels - plasma measure: Changes in propionate levels - stool measure: Changes in propionate levels- plasma measure: Changes in acetate levels- stool measure: Changes in acetate levels- plasma sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Michigan city: Ann Arbor state: Michigan zip: 48109 country: United States name: Hayley Billingsley, PhD role: CONTACT phone: 734-726-0308 email: hbilings@med.umich.edu name: Scott Hummel, MD, MS role: PRINCIPAL_INVESTIGATOR lat: 42.27756 lon: -83.74088 hasResults: False
nctId: NCT06337799 id: 202210411 briefTitle: Use of Allied-health Professionals to Improve Treatment of Disease overallStatus: NOT_YET_RECRUITING date: 2026-10 date: 2030-03 date: 2030-03 date: 2024-03-29 date: 2024-03-29 name: University of Iowa class: OTHER briefSummary: The goal of this clinical trial is to learn if allied-health professionals can recruit and follow research participants, sustain engagement, and improve and diagnose treatment of diseases by facilitating transitions of care.
Take their blood pressure at home and return it to the research team; Follow up with a research pharmacist for 12 months; Return for a follow up visit after 12 months. conditions: Preeclampsia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 200 type: ESTIMATED name: Research Pharmacist measure: Number of Subjects at Risk for Hypertension measure: Number of Subjects Exposed to a Screening Clinic measure: Number of Subjects Screened at a Screening Clinic measure: Number of Subjects Followed-Up by the Research Pharmacist measure: Number of Subjects Diagnosed with Hypertension measure: Number of Subjects Treated for Hypertension, if Diagnosed sex: FEMALE minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT hasResults: False
nctId: NCT06337786 id: MSK-2023-TSJ1 briefTitle: Investigating the Effects of the Digital App Rheumabuddy4.1 in a Clinical Set-up in Patients With Rheumatoid Arthritis overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-01 date: 2025-01 date: 2024-03-29 date: 2024-04-05 name: Henning Bliddal class: OTHER name: Eurostars name: DAMAN name: Medical University of Vienna briefSummary: Rheumatoid arthritis (RA) is one of the most frequently occurring autoimmune rheumatic diseases, affecting an estimated 1% of the global population (1). RA is a chronic inflammatory disease that leads to the development of synovial inflammation and effusion, ultimately followed by joint destruction and permanent disability.
The importance of patients' perspectives concerning disease- and treatment related impacts, is of crucial importance when involving patients in decisions about treatment, and to support the patients in optimal medication-taking behaviour to ensure patient health and reduce health care costs. There are still unmet needs that have a huge impact on quality of life (QoL) such as fatigue, pain, sleep and psychological issues, etc, which need to be taken seriously as these can have severe and debilitating consequences for the individual.
The aim of this study is to investigate and evaluate the effects of the digital app RheumaBuddy4.1 (RB4.1) and the ability to provide support and increase quality of life in patients with RA conditions: Rheumatoid Arthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The trial is an open-label matched register controlled clinical trial with two parallel groups (intervention and matched controls from the DANBIO register).
The number of study participants is 40 in the intervention arm and up to 120 in the matched control arm. primaryPurpose: OTHER masking: NONE count: 160 type: ESTIMATED name: Digital app RB4.1 name: Control arm measure: Primary Outcome measure: Disease-activity Score28 using C-reactive protein (DAS28-CRP) measure: Self-Efficacy measure: Pain and Fatigue measure: Health related quality of life measure: Physical function/activity measure: Well-Being measure: Medication Adherence measure: Better alignment between patient and health care professionals sex: ALL minimumAge: 18 Years maximumAge: 74 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Parker Institute, Bispebjerg and Frederiksberg Hospital city: Frederiksberg state: Copenhagen F zip: 2000 country: Denmark name: Tanja Schjødt Jørgensen role: CONTACT phone: +4538164173 email: tanja.schjoedt.joergensen@regionh.dk name: Lars Erik Kristensen role: CONTACT phone: +4538164157 email: lars.erik.kristensen@regionh.dk lat: 55.67938 lon: 12.53463 hasResults: False
nctId: NCT06337773 id: B-BR-112-036 briefTitle: Developing the Precision Nursing Education Program to Young Colorectal Cancer Survivors overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2024-09-30 date: 2026-12-25 date: 2024-03-29 date: 2024-03-29 name: Fooyin University class: OTHER briefSummary: This study is aimed to demonstrate the long-term effectiveness of 8-week precision nursing education program through the e-flipped classroom model for YCC survivors and provide a compliant strategy to improve quality of life and emotional status of these patients. conditions: Depression studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 110 type: ESTIMATED name: 8-weeks's on-line precision nursing education program measure: The depression symptoms on young colorectal cancer survivors measure: Dispositional mindfulness status on young colorectal cancer survivors measure: General quality of life on young colorectal cancer survivors measure: Colorectal specific quality of life on young colorectal cancer survivors measure: Cancer threat appraisal on young colorectal cancer survivors sex: ALL minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT hasResults: False
nctId: NCT06337760 id: IEO 1669 briefTitle: YOUNg Adults With Gastro-inteSTinal (GI) and nEuroendocrine canceRs. acronym: YOUNGSTER overallStatus: RECRUITING date: 2023-03-10 date: 2026-12-31 date: 2027-06-30 date: 2024-03-29 date: 2024-03-29 name: European Institute of Oncology class: OTHER briefSummary: The objective of the study is to create a common and unique platform for the acquisition of biological samples and, subsequently, the possible identification of predictive and prognostic biomarkers for young adults with gastrointestinal and neuroendocrine cancers.The definition "adolescent and young adults (AYA)" covers a broad group of patients ranging from the upper limit of the paediatric competence to the youngest patients usually considered and treated as adults. However, a well-defined and universally accepted age range is still not established. Young adults with cancer have distinct epidemiological, biological, and clinical characteristics, as well as special medical and psychosocial needs that are often unmet. In consideration of their poor representation in clinical studies, as well as the rarer, albeit increasing, frequency at an epidemiological level, knowledge of the risk factors associated with cancers in young adults is very poor. It is therefore of fundamental importance to focus attention on this specific cohort of patients, in order to describe in ever more detail any specific biomolecular aspects, and make full use of the pharmacological resources currently available. conditions: Neuroendocrine Neoplasm conditions: Adenocarcinoma studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: OTHER count: 90 type: ESTIMATED measure: Numbers of partecipants with genetic alterations measure: Number of partecipants with survival outcomes measure: Number of partecipants toxicities sex: ALL minimumAge: 18 Years maximumAge: 39 Years stdAges: ADULT facility: European Institute of Oncology status: RECRUITING city: Milan country: Italy name: Lorenzo Gervaso, MD role: CONTACT name: Chiara Alessandra Cella, MD role: SUB_INVESTIGATOR name: Luca Mazzarella, MD role: SUB_INVESTIGATOR lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06337747 id: 04-2023-PLLA briefTitle: Comparing Injections With Poly-L-Lactic Acid in the Temporal Fossa vs. Extended Temporal Fossa + Hairline overallStatus: RECRUITING date: 2023-05-19 date: 2024-04-30 date: 2024-06 date: 2024-03-29 date: 2024-03-29 name: Erevna Innovations Inc. class: OTHER briefSummary: The use of poly-L-Lactic acid (PLLA) has demonstrated significant improvement in multiple facial and body regions. Its use in the temporal fossa is the ideal location to demonstrate its impact on neocollagenesis given its distinct anatomic boundaries. Furthermore, the fact that the lateral boundary of the temporal region can extend into the hairline allows for a graded effect to be measured. Therefore, this study aims to extend these findings by evaluating the efficacy and safety of two injection techniques for volumizing temporal hollows. conditions: Aging studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescription: A prospective, randomized-controlled trial primaryPurpose: TREATMENT masking: NONE count: 24 type: ESTIMATED name: Traditional technique name: Experimental technique measure: To access the efficacy of the tradition and experimental technique measure: To access the safety of the tradition and experimental technique sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Erevna Innovations Inc status: RECRUITING city: Montreal state: Quebec zip: H3R 3A1 country: Canada name: Andreas Nikolis, MD role: CONTACT phone: 514-488-0163 email: research@vicpark.com lat: 45.50884 lon: -73.58781 hasResults: False