hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06283186 id: CSEULS-PI-004/2024 briefTitle: Comparative Exercise-Induced Hypoalgesia in Upper and Lower Limbs: A Randomized Controlled Trial in Healthy Individuals overallStatus: RECRUITING date: 2024-04-23 date: 2025-07-31 date: 2025-07-31 date: 2024-02-28 date: 2024-04-24 name: Centro Universitario La Salle class: OTHER briefSummary: This randomized controlled trial with healthy subjects aims to compare exercise-induced hypoalgesia among three groups: one utilizing a lower limb cycle ergometer, another using an upper limb cycle ergometer, and a control group. The exercise protocol involves 30 minutes of aerobic activity at 70-80% of the heart rate reserve. Exercise-induced hypoalgesia will be assessed by measuring pressure pain thresholds in the thigh and elbow. Additionally, a secondary objective is to compare the lower limb and upper limb cycle ergometer groups in terms of their effects on pressure pain thresholds in the thigh and elbow. Thus, the study anticipates observing differences in local and distal hypoalgesia based on the trained region. conditions: Healthy Subjects studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: Aerobic exercise name: Aerobic exercise measure: Pressure pain threshold (PPT) on dominant quadriceps and dominant lateral epicondyle measure: International Physical Activity Questionnaire (IPAQ) measure: Fatigue Assessment Scale (FAS) measure: Heart rate measure: Rate of perceived exertion (RPE) measure: Physical Activity Readiness Questionnaire (PAR-Q) sex: ALL minimumAge: 18 Years maximumAge: 64 Years stdAges: ADULT facility: CSEU LaSalle status: RECRUITING city: Madrid zip: 28023 country: Spain name: Álvaro Reina-Varona, MSc role: CONTACT phone: 0034 + 649001863 email: alvaroreina93@gmail.com name: Álvaro Reina-Varona, MSc role: PRINCIPAL_INVESTIGATOR lat: 40.4165 lon: -3.70256 hasResults: False
nctId: NCT06283173 id: 23-401 briefTitle: HRIPT for Collagen Dressing overallStatus: COMPLETED date: 2024-01-31 date: 2024-03-22 date: 2024-03-22 date: 2024-02-28 date: 2024-04-16 name: Covalon Technologies Inc. class: INDUSTRY name: ALS Beauty and Personal Care briefSummary: The objectives of this study are to determine by repetitive epidermal contact, the primary or cumulative irritation and the allergic contact sensitization potential of the ColActive Plus Collagen Matrix Dressing, under maximized conditions, with controlled product quantity and application site. conditions: Skin Sensitisation studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This will be a single center, with no randomization or blinding, study design in 50 healthy adult subjects, age 18-70 years. Based on prior experience approximately 75 subjects will be enrolled to ensure 50 subjects complete the study. primaryPurpose: OTHER masking: NONE count: 57 type: ACTUAL name: ColActive Plus Collagen Matrix Dressing measure: Skin sensitization reaction using Berger and Bowman scale measure: Skin irritation reaction using Berger and Bowman scale measure: Skin sensitization reaction using Berger and Bowman scale measure: Skin sensitization reaction using Berger and Bowman scale sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ALS Beauty and Personal Care city: Torrance state: California zip: 90501 country: United States lat: 33.83585 lon: -118.34063 hasResults: False
nctId: NCT06283160 id: 2023/834 briefTitle: Metabolomic and Immune Profiling in the Development of Pancreatic Fistulas After Cephalic Duodenopancreatectomy acronym: PROMETHEE overallStatus: RECRUITING date: 2024-03-01 date: 2026-05-30 date: 2026-05-30 date: 2024-02-28 date: 2024-04-12 name: Centre Hospitalier Universitaire de Besancon class: OTHER briefSummary: Pancreaticoduodenectomy is the standard surgical operation for benign or malign pancreatic lesions. Pancreatic Fistula (PF) or Postpancreatectomy Acute Pancreatitis (PPAP) are the major complications associated with that type of surgery. We need to develop preventive measures for these complications, which requires a better understanding of their physiopathology.
Participants will be adult patients scheduled to undergo elective pancreaticoduodenectomy. Surgery and patient's management will be as usual. During surgery, a fragment (0.1-0.2 g) of non-tumoral pancreatic tissue will be removed and frozen at -80°C for metabolomic analysis. For immunological assessment, 4 blood samples will be collected (before surgery and then 7 days, 1 and 3 months after, blood sampling). conditions: Pancreatic Fistula conditions: Acute Pancreatitis studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 80 type: ESTIMATED measure: occurrence of clinically significant FP and/or PAPP during hospitalization following pancreaticoduodenectomy. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital of Besançon status: RECRUITING city: Besançon zip: 25000 country: France name: Alexandre Doussot, MD, PhD role: CONTACT lat: 47.24878 lon: 6.01815 hasResults: False
nctId: NCT06283147 id: 2023.530 briefTitle: Risk Assessment and Management Program (RAMP) on Knee Osteoarthritis in Primary Care overallStatus: RECRUITING date: 2024-04-01 date: 2025-11-30 date: 2026-04-01 date: 2024-02-28 date: 2024-03-22 name: Chinese University of Hong Kong class: OTHER briefSummary: The goal of this clinical trial is to determine the clinical effectiveness of a Chronic Care Model (CCM) named Risk Assessment and Management Program on Knee OA (RAMP-Knee OA) in adults with knee Osteoarthritis (Knee OA) at 52 weeks.
Outcomes will be measured at baseline, week 16, week 32, and week 52. conditions: Knee Osteoarthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study is a 52-week, two-arm, parallel, doubled-blinded randomized clinical trial, evaluating the clinical efficacy of RAMP-Knee OA (N=114) versus usual care (N=114) on self-reported knee pain and other secondary outcomes. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE maskingDescription: All data collection will be performed by trained research assistants blinded to the allocation status of the patients, and statistician will analyse data without referring to allocation information. whoMasked: OUTCOMES_ASSESSOR count: 228 type: ESTIMATED name: Risk assessment and Management Programme - Knee Osteoarthritis measure: Knee pain measure: Physical Function measure: Physical function measure: Lower limb muscle mass measure: Level of physical activity measure: Self-Management efficacy measure: Level of Anxiety measure: Level of Depression measure: Insomnia measure: Loneliness measure: Health related Quality of Life measure: Demographic data sex: ALL minimumAge: 45 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Lek Yuen GOPC status: RECRUITING city: Hong Kong country: Hong Kong name: Cheryl Fung role: CONTACT phone: 26095050 phoneExt: +852 email: cheryllcfung@cuhk.edu.hk lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06283134 id: BJCT-CMU1H-02 briefTitle: A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-02 date: 2027-12-01 date: 2027-12-01 date: 2024-02-28 date: 2024-02-29 name: China Medical University, China class: OTHER name: Beijing Bio-Targeting Therapeutics Technology Co., Ltd briefSummary: This is a phase I, open-label clinical study of BioTTT001 in combination with Toraplizumab and Regorafenib in patients with liver metastases from colorectal cancer. conditions: Colorectal Cancer Metastatic studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: BioTTT001 hepatic artery infusion name: toripalimab name: regorafenib measure: Incidence of adverse events measure: MTD measure: Overall survival(OS) measure: Progression-free survival (PFS) measure: Objective response rate (ORR) measure: Plasma adenovirus (ADV) copies measure: ADV copies in various sites measure: Serum IL-12 level measure: Serum neutralizing antibody level sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06283121 id: BJCT-CMU1H-01 briefTitle: A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-02 date: 2027-11-30 date: 2027-11-30 date: 2024-02-28 date: 2024-02-29 name: China Medical University, China class: OTHER name: Beijing Bio-Targeting Therapeutics Technology Co., Ltd briefSummary: This is a phase I, single arm, open-label clinical study of BioTTT001 in combination with SOX and Toraplizumab in patients with peritoneal metastases from gastric cancer. conditions: Gastric Cancer, Metastatic studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: BioTTT001 intraperitoneal infusion name: SOX regimen name: toripalimab measure: Objective response rate (ORR) measure: Progression-free survival (PFS) measure: Overall survival (OS) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06283108 id: 23-1183 briefTitle: Gurney Journey: Virtual Reality Distraction overallStatus: RECRUITING date: 2024-03-01 date: 2024-06 date: 2024-06 date: 2024-02-28 date: 2024-03-08 name: Children's Hospital Colorado class: OTHER briefSummary: The aim of this study is to determine whether a software virtual reality (VR) program provided during transportation to anesthesia induction reduces anxiety before the procedure, and compliance in pediatric patients. This study aims to measure the anxiety of patients as they arrive before their procedure, when parting from their parents for transportation to the procedure room, and when anesthesia is provided. Compliance during anesthesia induction will also be monitored. Participants will be randomly placed into to one of two groups. Group 1 will receive standard care from a Certified Child Life Specialist prior to their surgery. Group 2 will receive standard care from a Certified Child Life Specialist and distraction with a novel virtual reality software program. conditions: Dental Caries in Children conditions: Dental Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 58 type: ESTIMATED name: Standard Child Life Preparation and Support + Meta Quest 2 VR headset with Gurney Journey (a mixed reality experience) name: Standard Child Life Preparation and Support measure: Induction Compliance Checklist measure: modified Yale Preoperative Anxiety Scale measure: The Pediatric Behavioral Induction Assessment sex: ALL minimumAge: 5 Years maximumAge: 17 Years stdAges: CHILD facility: Children's Hospital Colorado status: RECRUITING city: Aurora state: Colorado zip: 80045 country: United States name: Claire Simonsen, BA role: CONTACT phone: 720-777-5313 email: claire.simonsen@childrenscolorado.org name: Joseph Albietz, MD role: PRINCIPAL_INVESTIGATOR name: Jennifer Staab, MS role: SUB_INVESTIGATOR lat: 39.72943 lon: -104.83192 hasResults: False
nctId: NCT06283095 id: OSA briefTitle: Management of Obstructive Sleep Apnea Syndrome by Expansion Palatoplasty overallStatus: RECRUITING date: 2023-11-01 date: 2025-11-01 date: 2026-11-01 date: 2024-02-28 date: 2024-02-28 name: ET Zarief class: OTHER briefSummary: The study will be conducted to evaluate the outcome of expansion palatoplasty in management of OSAS. conditions: Obstructive Sleep Apnea of Adult studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: expansion palatoplasty measure: Evaluation the outcome of expansion palatoplasty in management of OSAS. measure: Expansion palatoplasty in Obstructive sleep apnea patients sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ASSUIT status: RECRUITING city: Assuit zip: 1 country: Egypt name: Enas T Zarief, physician role: CONTACT phone: 01226270800 email: enas.tharwat23@gmail.com lat: 27.18096 lon: 31.18368 hasResults: False
nctId: NCT06283082 id: 69HCL23_0617 id: ID-RCB type: OTHER domain: 2023-A01406-39 briefTitle: Oxalate Excretion Profile in Patients With a Heterozygous Mutation of the AGXT (Alanine-glyoxylate Aminotransferase) Gene acronym: HETEROX overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-02-28 date: 2024-02-28 name: Hospices Civils de Lyon class: OTHER briefSummary: Primary hyperoxaluria type I (PH1) is a rare genetic disorder responsible for severe lithiasis leading to progressive deterioration of renal function and end-stage renal failure. PH1 is linked to a deficiency in glyoxylate amino transferase (AGXT), which leads to increased endogenous oxalate synthesis and hyperoxaluria. In the urine, urinary oxalate precipitates with calcium, forming insoluble crystals, leading to lithiasis and the development of nephrocalcinosis.
The hypothesis is that there is an increase in hepatic oxalate production in heterozygous patients, which explains why they remain asymptomatic under usual conditions, but could favor stone formation under favorable conditions such as severe calcium deficiency or malabsorption. conditions: Hyperoxaluria (Disorder) studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: NONE count: 25 type: ESTIMATED name: Lithiasis assessment measure: Urinary oxalate and glycolate excretion measure: The prevalence of stones measure: Lithiasis disease severity measure: Lithiasis disease severity measure: Lithiasis disease severity measure: Lithiasis disease severity measure: Predisposing conditions for lithiasis disease measure: Predisposing conditions for lithiasis disease sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CLIMA, pavillon R, Hôpital Edouard Herriot city: Lyon zip: 69003 country: France name: Laurence Derain, MD,PhD role: CONTACT phone: 04 72 11 91 17 phoneExt: +33 email: laurence.derain@chu-lyon.fr lat: 45.74848 lon: 4.84669 hasResults: False
nctId: NCT06283069 id: 45C301 briefTitle: Relationship Between Lifestyle Indicators and Cardiovascular Clinical Parameters acronym: RICH overallStatus: RECRUITING date: 2023-05-01 date: 2024-12-31 date: 2033-04-30 date: 2024-02-28 date: 2024-02-28 name: Istituto Auxologico Italiano class: OTHER briefSummary: The goal of the study is to build a Register accruing data derived from the compilation of the questionnaire about LifeStyle for a population both of adults and of young boys and girls. The investigators are confident that in this way they will be able to expand the database they already have. The investigators will be able to increase the strength of the correlations between LS indices and health indicators. In particular, the investigators will emphasize the relationship between physical activity, stress, and diet quality on one hand, and on the other, they will focus on physiological parameters, like arterial pressure, gluco-lipid profile, and possible pathologies. conditions: Cardiovascular Diseases conditions: Lifestyle conditions: Nutrition, Healthy conditions: Physical Inactivity conditions: Stress conditions: Sleep studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: OTHER count: 100 type: ESTIMATED name: compilation of a questionnaire about LifeStyle measure: weekly physical activity volume measure: nutrition quality measure: weight measure: height measure: blood pressure measure: perception of stress, fatigue, and somatic symptoms measure: glycemia measure: cholesterol measure: creatinine measure: waist circumference measure: heart rate sex: ALL minimumAge: 6 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Istituto Auxologico Italiano status: RECRUITING city: Milan country: Italy name: Luca Giovanelli, MD role: CONTACT phone: +3902619112808 email: luca.giovanelli@unimi.it name: Daniela Lucini, Prof role: PRINCIPAL_INVESTIGATOR lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06283056 id: DO611073A briefTitle: RF Microneedling With Multi-Depth Targeting Per Insertion for The Treatment of Cellulite overallStatus: RECRUITING date: 2022-06-16 date: 2024-06-01 date: 2025-06-01 date: 2024-02-28 date: 2024-02-28 name: InMode MD Ltd. class: INDUSTRY briefSummary: The aim of the study is to evaluate the safety and efficacy of Morpheus 8 Body 40-pin tip up to 7mm depth Applicator for subdermal treatment of cellulite appearance, skin laxity, and subcutaneous fat deposits. conditions: Cellulitis of Leg studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Prospective, open-label clinical study. primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: Device treatment measure: Cellulite assessment based on Clinician Reported Photonumeric Cellulite Severity Scale measure: Cellulite assessment based on DiBernardo Photonumeric Cellulite Severity Scale measure: Subject assessment of improvement measure: Subject assessment of improvement measure: Subject assessment of improvement measure: Subject assessment of satisfaction measure: Subject assessment of satisfaction measure: Subject assessment of satisfaction measure: Investigator assessment of the skin appearance improvemen measure: Investigator assessment of the skin appearance improvement measure: Investigator assessment of the skin appearance measure: Investigator assessment of the cellulite following subdermal Morpheus8 treatment measure: Investigator assessment of the cellulite following subdermal Morpheus8 treatment measure: Investigator assessment of the cellulite following subdermal Morpheus8 treatment measure: Adverse Event rate measure: Pain Scale sex: FEMALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Dermatology & Laser Surgery Center of New York status: ACTIVE_NOT_RECRUITING city: New York state: New York zip: 10028 country: United States lat: 40.71427 lon: -74.00597 facility: Dallas Plastic Surgeon status: RECRUITING city: Dallas state: Texas zip: 75225 country: United States name: Lily Hays role: CONTACT phone: 214-821-9114 email: Lily Hays <lily.hays@dpsi.org> lat: 32.78306 lon: -96.80667 hasResults: False
nctId: NCT06283043 id: 2022/3749 briefTitle: Effect of Motor Function, Depression and Sleep Quality on Attention in Parkinson's Disease overallStatus: ENROLLING_BY_INVITATION date: 2024-01-01 date: 2024-03-01 date: 2024-03-05 date: 2024-02-28 date: 2024-02-28 name: Inonu University class: OTHER briefSummary: Our study was planned to analyze motor function, endurance and sleep attention information in Parkinson's patients with detailed and objective measurements. conditions: Movement Disorders (Incl Parkinsonism) conditions: Parkinsonian Disorders conditions: Attention Impaired conditions: Movement Disorders, Functional studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 54 type: ESTIMATED measure: TUG measure: 10 m walking test measure: 30 sec sit-stand test measure: berg balance test measure: one leg stance test measure: functional reach test measure: hand dinamometer measure: mobil application measure: Pittsburg Sleep Quality İndex measure: Beck Depression measure: P300 sex: ALL minimumAge: 40 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Inonu University city: Malatya state: Battalgazi zip: 44280 country: Turkey lat: 38.35018 lon: 38.31667 hasResults: False
nctId: NCT06283030 id: IM-001 briefTitle: Evaluation of Hypoglossal Nerve Stimulation in Humans With Obstructive Sleep Apnea overallStatus: COMPLETED date: 2021-12-01 date: 2023-09-25 date: 2023-09-25 date: 2024-02-28 date: 2024-03-07 name: Invicta Medical Inc. class: INDUSTRY name: Vanderbilt University Medical Center briefSummary: This proof-of-concept study is being performed to evaluate whether the hypoglossal nerve can be stimulated using a small series of electrodes placed surgically via a percutaneous approach. Minimally invasive off the shelf medical devices will be used and observation of the characteristic physiological responses to stimulation of the HGN, will be assessed. conditions: Sleep Apnea conditions: Sleep Apnea, Obstructive conditions: Sleep Apnea Syndromes conditions: Sleep Disorder studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 14 type: ACTUAL name: Hypoglossal nerve stimulation measure: Identification and access of the target outcomes measure: Tongue protrusion outcomes measure: Characterization of electrode array outcomes measure: Electrode array placement and removal outcomes measure: Safety outcomes sex: ALL minimumAge: 21 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Vanderbilt Bill Wilkerson Centre city: Nashville state: Tennessee zip: 37232 country: United States lat: 36.16589 lon: -86.78444 hasResults: False
nctId: NCT06283017 id: IM-002 briefTitle: Evaluation of the Effects of Hypoglossal Nerve Stimulation in Humans With Obstructive Sleep Apnea overallStatus: ACTIVE_NOT_RECRUITING date: 2022-06-01 date: 2024-03 date: 2024-03 date: 2024-02-28 date: 2024-03-13 name: Invicta Medical Inc. class: INDUSTRY name: Adelaide Institute for Sleep Health, Flinders University briefSummary: This proof-of-concept study is being performed to evaluate whether the hypoglossal nerve can be stimulated using a small series of electrodes placed surgically via a percutaneous approach. Minimally invasive off the shelf medical devices will be used and observation of the characteristic physiological responses to stimulation of the HGN, will be assessed. conditions: Sleep Apnea conditions: Sleep Apnea, Obstructive conditions: Sleep Disorder conditions: Sleep Apnea Syndromes studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 14 type: ACTUAL name: Hypoglossal nerve stimulation measure: Target identification and access outcomes measure: Tongue protrusion outcomes measure: Characterization of lead placement outcomes measure: Lead placement and removal outcomes measure: Safety outcomes sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Adelaide Institute for Sleep Health, Flinders University city: Adelaide state: South Australia zip: 5042 country: Australia lat: -34.92866 lon: 138.59863 hasResults: False