hackint0sh/New-Dataset huggingface dataset:
The project has collected high-quality data from nearly a thousand breast PT patients, including imaging, histopathology, and survival data, and has performed transcriptome gene sequencing on tissue samples. They aim to build a comprehensive multi-omics database for breast PT and create an AI-based model for early diagnosis and prognosis prediction. This research has the potential to improve the diagnosis and treatment of breast PT, address the disparities in breast PT care across different regions in China, and contribute to the development of new therapeutic targets. conditions: Phyllodes Breast Tumor conditions: Artificial Intelligence conditions: Multiomics conditions: Prognostic Cancer Model conditions: Diagnosis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 4000 type: ESTIMATED name: imaging measure: Sensitivity measure: False-negative Rate measure: Specificity measure: False-positive Rate measure: Receiver Operating Characteristic Curve measure: Area under roc Curve sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Sun Yat-sen University Cancer Center status: RECRUITING city: Guangzhou state: Guangdong zip: 510050 country: China name: Feng Ye, Prof.Dr. role: CONTACT phone: 15914388994 lat: 23.11667 lon: 113.25 facility: Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University status: RECRUITING city: Guangzhou state: Guangdong zip: 510120 country: China name: Yan Nie, Prof.Dr. role: CONTACT phone: +86 020-81332587 email: nieyan7@mail.sysu.edu.cn lat: 23.11667 lon: 113.25 facility: The Third Affiliated Hospital of Guangzhou Medical University status: RECRUITING city: Guangzhou state: Guangdong zip: 510145 country: China name: Hui Mai, Prof.Dr. role: CONTACT phone: 13925129112 lat: 23.11667 lon: 113.25 facility: Guangdong Maternal and Child Health Hospital status: RECRUITING city: Guangzhou state: Guangdong zip: 511400 country: China name: Yu Tan, Prof.Dr. role: CONTACT phone: 13632356526 lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06286241 id: 877/2564(IRB2) briefTitle: Comparison of the Complications in Multiple Myeloma Patients Who Received Autologous Stem Cell Transplantation Between in HEPA-filtered Room and Non-HEPA-filtered Room acronym: Step down ward overallStatus: NOT_YET_RECRUITING date: 2024-03-25 date: 2024-06-30 date: 2024-07-30 date: 2024-02-29 date: 2024-03-15 name: Siriraj Hospital class: OTHER name: Faculty of Medicine Siriraj Hospital briefSummary: The goal of this observational study is to comparison of the complications in multiple myeloma patients who received autologous stem cell transplantation between in HEPA-filtered room and non-HEPA-filtered room. The main questions it aims to answer are:
* 2-year progression free survival Participants will be collected the data of baseline diagnosis, treatment, treatment results and complications during admission and follow-up visits from hospital medical record. conditions: Multiple Myeloma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 344 type: ESTIMATED measure: febrile neutropenia measure: Infection measure: duration of admission measure: progression free survival sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06286228 id: 751/2563(IRB4) briefTitle: Registry of Haploidentical Hematopoietic Stem Cell Transplantation in Adult With Hematologic Disease acronym: Haplo overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2029-04-01 date: 2030-04-01 date: 2024-02-29 date: 2024-03-01 name: Siriraj Hospital class: OTHER name: Faculty of Medicine Siriraj Hospital briefSummary: The goal of this observational study is to register hematologic patients with haploidentical hematopoietic stem cell transplantation (haploHSCT). The main questions it aims to answer are:
* Comparison cost-effectiveness of treatment between matched sibling donor (MSD) HSCT and matched unrelated donor (MUD) HSCT Participants will be collected the data of baseline diagnosis, treatment, treatment results of all admission and follow-up visits from hospital medical record. conditions: Multiple Myeloma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 43 type: ESTIMATED measure: register hematologic patients with haploidentical hematopoietic stem cell transplantation measure: progression free survival rate measure: overall survival rate measure: Chronic Graft-versus-host free relapsed free survival measure: Relapsed rate measure: Primary and late graft failure measure: Rate of Neutrophil and platelet engraftment measure: Efficacy of donor specific antibody desensitization measure: Safety and complication of haploHSCT measure: Complication of viral, bacterial, and fungal infection measure: Viral reactivation measure: outcomes between matched sibling donor (MSD) HSCT and matched unrelated donor (MUD) HSCT measure: cost-effectiveness of treatment between matched sibling donor (MSD) HSCT and matched unrelated donor (MUD) HSCT sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06286215 id: 586/2564(IRB2) briefTitle: Registry of Patients With Plasma Cell Disorders acronym: Registry PCD overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2034-04-01 date: 2035-04-01 date: 2024-02-29 date: 2024-02-29 name: Siriraj Hospital class: OTHER name: Faculty of Medicine Siriraj Hospital briefSummary: The goal of this observational study is to register patients with plasma cell disorders. The main questions it aims to answer are:
* cost-effectiveness of treatment in Thailand Participants will be collected the data of baseline diagnosis, treatment, treatment results of all admission and follow-up visits from hospital medical record. conditions: Plasma Cell Disorders studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 750 type: ESTIMATED measure: register the plasma cell disorder patients measure: incidence of plasma cell disorders measure: Time to progression measure: Progression free survival measure: overall survival measure: influencing factors measure: Symptoms and signs measure: genetic characteristics measure: cost-effectiveness sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06286202 id: RECAS-0306 briefTitle: Integrative Neuro-social Cognitive Strategy Programme for Instilling REcovery (INSPIRE) a Community-Based Cognitive Remediation Trial overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-12 date: 2027-07 date: 2024-02-29 date: 2024-03-04 name: Singapore Institute of Technology class: OTHER name: Singapore Anglican Community Services briefSummary: Adults with serious mental illnesses (such as schizophrenia and schizoaffective disorders) often experience a range of cognitive difficulties (such as memory, problem solving difficulties) that affect their ability to lead meaningful life roles. Cognitive remediation is an intervention to address cognitive difficulties in this group of mental health service users. Its implementation in less well-resourced community-based settings is less well-studied.
This research study will compare the differences in their cognitive performance, functional ability and recovery immediately after the intervention and 8 weeks later. conditions: Schizophrenia conditions: Schizoaffective Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The intervention study model is a parallel randomized controlled trial. There will be two arms. The experimental arm is 'cognitive remediation' and the control arm is 'standard psychiatric rehabilitation'. Participants will be assigned to one of the treatment arms at the beginning of the trial and will continue in that arm throughout the length of the trial. Assignment to the group is done using a computer randomization generator. All eligible participants will be randomly assigned to one of the treatment arms (experimental or control arm) based on a 1:1 treatment allocation. Hence, those who are randomly allocated to the experimental arm will receive cognitive remediation throughout the trial, while those randomly allocated to the control arm will receive standard psychiatric rehabilitation throughout the trial. Both treatment arms will run in parallel. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Upon randomization, the co-investigators will indicate the allocated group in a separate spreadsheet from the outcome measurements. The co-investigator who is collecting baseline, post-intervention and 8-week outcome measurements will be blinded to the treatment allocation of each participant. whoMasked: OUTCOMES_ASSESSOR count: 160 type: ESTIMATED name: Cognitive Remediation: Adapted Neuropsychological and Education Approach to Remediation (NEAR) name: Standard Psychiatric Rehabilitation at Anglican Care Centers measure: Brief Assessment of Cognition in Schizophrenia (BACS) measure: Penn Emotion Recognition Task (ER40) measure: The Awareness of Social Inference Test (TASIT)- Part 3 measure: Goal Attainment Scale measure: Social and Occupational Functioning Assessment Scale (SOFAS) measure: Recovery Assessment Scale-Domain and Stages (RAS-DS) measure: Positive and Negative Syndrome Scale (PANSS) measure: Brief Negative Symptom Scale (BNSS) measure: Brief Regulation of Motivation Scale (BRoMS) measure: The Global Assessment of Functioning Scale (GAF) sex: ALL minimumAge: 21 Years maximumAge: 60 Years stdAges: ADULT facility: Anglican Care Center-Bukit Batok city: Singapore country: Singapore name: Jonathan Poh, MA role: CONTACT phone: +6592333020 email: Jonathan_poh@sacs.org.sg lat: 1.28967 lon: 103.85007 facility: Anglican Care Center-Hougang city: Singapore country: Singapore name: Mingxiu Cai, BSc (Hons) role: CONTACT phone: +6563869338 phoneExt: 101 email: mingxiu_cai@sacs.org.sg lat: 1.28967 lon: 103.85007 facility: Anglican Care Center-Simei city: Singapore country: Singapore name: Noel Tan, MA role: CONTACT phone: +6591853094 email: noel_tan@sacs.org.sg lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06286189 id: 2020P002760-t briefTitle: Trazodone on OSA Endotypes overallStatus: RECRUITING date: 2024-01-01 date: 2025-01-01 date: 2025-06-01 date: 2024-02-29 date: 2024-02-29 name: Brigham and Women's Hospital class: OTHER briefSummary: Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. Some OSA patients with low arousal threshold wake up prematurely during an obstructive event and do not have time for spontaneous upper airway (UA) dilator muscle recruitment. As a consequence they are exposed to apnea and hypopnea cycling. In this protocol the investigators will test the effect of trazodone administered before sleep on OSA traits and OSA severity during sleep. conditions: Obstructive Sleep Apnea studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 18 type: ESTIMATED name: Placebo oral tablet name: Trazodone Hydrochloride measure: Effect of trazodone on arousal threshold (%eupnea) measure: Effect of trazodone on apnea hypopnea index (events/h) sex: ALL minimumAge: 21 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Brigham and Women's Hospital status: RECRUITING city: Boston state: Massachusetts zip: 02115 country: United States name: Nicole Calianese, BS role: CONTACT phone: 617-732-8976 email: ncalianese@mgb.org lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06286176 id: LIUIRB-200311-NR1 briefTitle: Breastfeeding Promotion in Lebanon Through a Salutogenic Intervention overallStatus: COMPLETED date: 2022-11-17 date: 2023-06-30 date: 2023-06-30 date: 2024-02-29 date: 2024-02-29 name: Nabiha Ramadan class: OTHER name: Universitat de Girona briefSummary: The study is a randomized control trial to assess the effect of a salutogenic intervention on breastfeeding initiation and duration of exclusive breastfeeding in Lebanon. In this Salutogenic intervention, infant feeding helpers will provide subjects of the intervention group breastfeeding related information , and will support these subjects by counseling and guiding them to find general resistance resources. This aims to increase sense of coherence and its parameters: comprehensibility, manageability and meaningfulness, which are the base of salutogenesis. conditions: Breast Feeding conditions: Exclusive Breastfeeding conditions: Salutogenesis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 101 type: ACTUAL name: Videos with breastfeeding education material and encouraging messages name: Whatsapp group measure: breastfeeding initiation measure: Duration of Exclusive breastfeeding measure: Mean change in Self- esteem in participants from baseline to 6 months postpartum measure: The Change in Sense of Coherence (SOC) scores from baseline to 6 months postpartum sex: FEMALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Lebanese International University city: Beirut zip: 146404 country: Lebanon lat: 33.88894 lon: 35.49442 hasResults: False
nctId: NCT06286163 id: PA4099 briefTitle: Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients overallStatus: RECRUITING date: 2023-10-01 date: 2024-12-31 date: 2025-06-30 date: 2024-02-29 date: 2024-02-29 name: Imperial College London class: OTHER name: Merck Sharp & Dohme LLC briefSummary: This study is being done in order to understand what causes people to have a chronic cough, which is defined as a cough lasting for more than 8 weeks. The research team wish to find out whether there is any inflammation in the lungs of patients with chronic cough. The research team will also determine whether a suspected chemical produced in the body, called adenosine triphosphate (ATP) can be responsible for causing the chronic cough. In order to be able to find out what is abnormal in those who have a chronic cough, The research team will need to compare their results with those that do not have a chronic cough.
In this study, the research team will examine 10 participants who suffer from chronic cough and 8 individuals who do not have a chronic cough and are healthy. conditions: Chronic Cough studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 18 type: ESTIMATED measure: Presence of ATP in airways of idiopathic chronic cough patients and the localisation of P2X2/3 receptors in the airways measure: Cough sensitivity and laryngeal sensitivity to exogenous ATP measure: Examine the effects of exogenous ATP on the inflammatory response in the upper and lower airways. sex: ALL minimumAge: 30 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Royal Brompton & Harefield NHS Trust, status: RECRUITING city: London zip: SW3 6HP country: United Kingdom name: Sally Meah, SRN role: CONTACT phone: 0207 3518051 email: Sally.Meah@imperial.ac.uk name: Pankaj K Bhavsar role: CONTACT phone: 02075947961 email: p.bhavsar@imperial.ac.uk lat: 51.50853 lon: -0.12574 facility: Royal Brompton Hospital status: RECRUITING city: London zip: SW3 6HP country: United Kingdom name: Kian Fan Chung, MD role: CONTACT phone: 44205947959 email: f.chung@imperial.ac.uk name: Sally Meah, SRN role: CONTACT phone: 02073518051 email: Sally.Meah@imperial.ac.uk lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06286150 id: EC-2023-087(QX)-03 briefTitle: Efficacy and Safety of Single-port Surgical Robot System in Thoraic Surgery overallStatus: RECRUITING date: 2023-09-15 date: 2025-07-15 date: 2027-07-15 date: 2024-02-29 date: 2024-02-29 name: The First Affiliated Hospital of Guangzhou Medical University class: OTHER briefSummary: Robotic surgical systems have become a promising surgical assistance system, with unique advantages such as 3D high-definition visual system, highly flexible wrist-jointed instruments, and automatic fitering of hand tremors. Robotic surgical systems is applied in various fields including urology, general surgery, cardiothoracic surgery, head and neck surgery, and gynecology. Currently, the Da Vinci surgical robot system is the most widely used robot system globally. However, the Da Vinci robot system for single-port laparoscopic surgery has not yet been launched in China. Therefore, the investigators conduct a prespective, single-center study to evaluate the efficacy and safety of single-port surgical robot system in thoracic surgery. conditions: Lung Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Surgical robot system measure: Intraoperative conversion rate measure: Surgical complications rate measure: Intraoperating bleeding volume measure: Surgical time measure: Length of hospital admissions measure: Postoperative wound pain score measure: Surgeon satisfaction measure: Adverse events measure: Rate of re-admission to hospital measure: Rate of reoperation measure: Postoperative mortality sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The First Affiliated Hospital of Guangzhou Medical University status: RECRUITING city: Guangzhou state: Guangdong zip: 510000 country: China name: Jianxing He, M.D. role: CONTACT phone: +86-20-83337792 email: hejx@vip.163.com lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06286137 id: NL82922.078.22 briefTitle: Duration of Music Interventions and Pain Tolerance (DOMINANT) acronym: DOMINANT overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-02 date: 2025-06 date: 2024-02-29 date: 2024-03-06 name: Erasmus Medical Center class: OTHER briefSummary: This study will investigate the effect of different durations of music interventions (1, 5 and 20 minutes of music) on pain tolerance. conditions: Pain, Acute studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The randomized controlled trial will have four study arms. Subjects will be assigned to one of the four arms: control without music and music groups with 1 minute, 5 minutes and 20 minutes. All subjects will receive electric stimuli in three phases. In each phase, subject will be exposed to three consecutive stimuli. First a detection threshold will be measured. Secondly a baseline test will be performed in order to assess basic levels of pain endurance. Hereafter, the intervention phase starts. Subjects in the music groups will listen to 1, 5 and 20 minutes of their own preferred music through headphones. Directly after, all subjects will again receive three electric stimuli. primaryPurpose: TREATMENT masking: NONE maskingDescription: Due to the nature of the study and the music intervention, it is not possible to blind participants and investigators. However, participants will not be informed of the study arm to which they are randomized in advance. count: 80 type: ESTIMATED name: Listening to music for 1 minute name: Listening to music for 5 minutes name: Listening to music for 20 minutes name: Not listening to music measure: Pain tolerance measure: Heart rate variability (HRV) measure: Level of perceived anxiety, Spielberger State-Trait Anxiety Inventory (STAI)-6 questionnaire measure: Valence and arousal, Self-Assessment manikin (SAM) questionnaire measure: Music listening Questionnaire measure: Pain intensity measure: Pain unpleasantness sex: ALL minimumAge: 18 Years maximumAge: 64 Years stdAges: ADULT facility: Erasmus Medical Center city: Rotterdam zip: 3015 GD country: Netherlands name: Emy S van der Valk Bouman, MD role: CONTACT phone: +31646461901 email: e.vandervalkbouman@erasmusmc.nl name: Antonia S Becker, MD role: CONTACT phone: +31641188966 email: a.becker@erasmusmc.nl name: Markus Klimek, MD PhD role: PRINCIPAL_INVESTIGATOR lat: 51.9225 lon: 4.47917 hasResults: False
nctId: NCT06286124 id: 8612 briefTitle: Midline Restoration After HYbriD Hernia RepAir Surgery (HYDRA) acronym: HYDRA overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2028-04 date: 2024-02-29 date: 2024-02-29 name: Erasmus Medical Center class: OTHER name: Medtronic name: Alrijne Hospital briefSummary: The goal of this observational study is to learn about the functioning of the abdominal wall in patients who underwent hybrid (open- and laparoscopic) incisional hernia repair. The main objective is to assess the anatomical restoration and function of the linea alba one year after surgery by ultrasonography and mean peak torque during trunk flexion using a BioDex machine. conditions: Incisional Hernia of Midline of Abdomen studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 52 type: ESTIMATED name: Hybrid Surgery measure: Mean peak torque 1 year measure: Mean peak torque 2 years measure: Recurrent Incisional Hernia measure: Severity of surgical complications measure: Surgical complications measure: General Quality of Life measure: Mesh specific Quality of Life measure: Scar satisfaction measure: Pain in the abdominal region sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Alrijne Hospital city: Leiden country: Netherlands name: Willem Hueting, MSc role: CONTACT lat: 52.15833 lon: 4.49306 hasResults: False
nctId: NCT06286111 id: ASU MD briefTitle: Red Cell Distribution Width as a Predictor for Post Operative Atrial Fibrillation After Open Heart Surgries overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2024-06-01 date: 2024-08-01 date: 2024-02-29 date: 2024-04-23 name: Ain Shams University class: OTHER briefSummary: In this study we investigate the correlation between RDW and POAF, as we use the RDW as a predictor for inflammation for prediction of POAF conditions: Atrial Fibrillation conditions: Inflammatory Marker conditions: Heart; Surgery, Heart, Functional Disturbance as Result studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 76 type: ESTIMATED measure: Red cell distribution width as a predictor for Post-operative Atrial fibrillation after Open Heart Surgeries sex: ALL minimumAge: 35 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06286098 id: ALA in Pediatrics on HD briefTitle: Alpha Lipoic Acid in Pediatrics on Hemodialysis overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2024-09-20 date: 2024-10-20 date: 2024-02-29 date: 2024-03-12 name: Ain Shams University class: OTHER name: Eva Pharma briefSummary: The goal of this clinical trial is to test alpha lipoic acid in children undergoing hemodialysis. The main questions it aims to answer are:
* undergo clinical examinations (Echocardiogram, Duplex ultrasonography, Intima-Media-Thickness) Researchers will compare between the group taking alpha lipoic acid and the group taking the look-alike tablet. conditions: Hemodialysis Complication conditions: Pediatric Kidney Disease conditions: Cardiovascular Complication studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 50 type: ESTIMATED name: Alpha lipoic acid name: Placebo measure: Serum level of E-Selectin measure: Serum levels of superoxide dismutase (SOD) measure: Number of cardiovascular events measure: Number of Adverse effects sex: ALL minimumAge: 8 Years maximumAge: 16 Years stdAges: CHILD facility: New Pediatrics Hospital, Faculty of Medicine, Ain Shams University city: Cairo state: El Weili zip: 11381 country: Egypt name: Mahmoud Mohsen, Pharmacist role: CONTACT phone: +201275811494 email: mahmoudfast41@gmail.com lat: 30.06263 lon: 31.24967 hasResults: False