hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06267274 id: MW230021 briefTitle: A Randomized, Double-blind, Parallel-group, Two-arm, Multiple Dose, Multicenter, Bioequivalence Study With Clinical Endpoint in the Treatment of Subjects With Chronic Open-angle Glaucoma or Ocular Hypertension in Both Eyes overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-03-01 date: 2025-05-01 date: 2024-02-20 date: 2024-03-29 name: Amneal Pharmaceuticals, LLC class: INDUSTRY name: CBCC Global Inc. name: Amneal EU, Limited briefSummary: A randomized, double-blind, parallel-group, two-arm, multiple dose, multicenter, clinical endpoint bioequivalence study conditions: Open-angle Glaucoma conditions: Ocular Hypertension studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Subjects will be randomized in such way that ratio of treatment distribution will be nearer to 1:1 between the treatment arms, and within the combined stratification criteria. primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: double-blind study whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 240 type: ESTIMATED name: Bimatoprost Ophthalmic Solution, 0.01% name: LUMIGAN® (bimatoprost ophthalmic solution) 0.01% measure: Primary Endpoint measure: Secondary Endpoint sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: West Coast Eye Institute city: Bakersfield state: California zip: 93308 country: United States name: Sandeep Walia, MD role: CONTACT lat: 35.37329 lon: -119.01871 facility: Eye Research Foundation city: Newport Beach state: California zip: 92663 country: United States name: David Wirta, MD role: CONTACT lat: 33.61891 lon: -117.92895 facility: Clayton Eye Research city: Morrow state: Georgia zip: 30260 country: United States name: Kim Jong, MD role: CONTACT lat: 33.58317 lon: -84.33937 facility: Houston Eye Associates city: Houston state: Texas zip: 77008 country: United States name: Kevin Jong, MD role: CONTACT lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06267261 id: KOL-001 briefTitle: Efficacy of Face Mask in Reducing Respiratory Allergic Symptoms in Birch-allergic Subjects in ALYATEC Exposure Chamber overallStatus: COMPLETED date: 2021-06-07 date: 2021-08-23 date: 2021-10-25 date: 2024-02-20 date: 2024-02-20 name: Alyatec class: INDUSTRY name: Medicom briefSummary: There is no clinical evidence that face masks are efficient in birch pollen-induced asthma. As the use of face masks has become widespread worldwide to limit the spread of SARS-CoV-2, this study aims to demonstrate the clinical efficacy of medical masks in patients allergic to birch in the same way that clinical trial with drugs. conditions: Allergic Asthma conditions: Allergic Rhinitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 24 type: ACTUAL name: KOLMI® surgical face mask (OP-Air) measure: Time to early asthma response (EAR) measure: Frequency of EAR and late asthma response (LAR) measure: Severity of EAR and LAR measure: Nasal Symptoms sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: ALYATEC city: Strasbourg country: France lat: 48.58392 lon: 7.74553 hasResults: False
nctId: NCT06267248 id: T05100 briefTitle: Spine Registration Using 3D-Scanning acronym: BWH overallStatus: ENROLLING_BY_INVITATION date: 2024-02 date: 2024-11 date: 2024-11 date: 2024-02-20 date: 2024-02-20 name: Advanced Scanners Inc. class: INDUSTRY briefSummary: The primary objective is to assess the capability of the device as measured by its consistency, its accuracy, and feedback from surgical staff over the study period. conditions: Spine Surgery studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 10 type: ESTIMATED name: Optical 3D Scanner measure: Spine Registration measure: Vertebral Shift Measurement measure: Determination Of Bony Exposure Requirements sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mass General Bringham, Hale Building for Transformative Medicine city: Boston state: Massachusetts zip: 02115 country: United States lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06267235 id: lowprotein briefTitle: Dietary Protein Restriction and Health acronym: LOWPRO overallStatus: COMPLETED date: 2018-01-01 date: 2020-01-31 date: 2024-01-31 date: 2024-02-20 date: 2024-04-17 name: University of Copenhagen class: OTHER briefSummary: The incidence of type 2 diabetes worldwide has increased significantly over the past decades, which is associated with changing dietary habits and physical inactivity. According to the diet, so far there has been a great focus on the quality of carbohydrates and fat in relation to metabolic health, while the importance of protein has been neglected. The Danes' average protein intake is 1.5 g/kg/day, which is at the high end of the recommendations (0.8-1.5 g/kg/day) from the Nordic Nutrition Recommendations (NNR 2023). Recent studies in rodents have shown that protein restriction has positive effects on health, including improved glucose and insulin homeostasis and reduced fat mass, while a high intake of protein has a negative effect on insulin sensitivity. Previously the investigators have shown, in healthy young men, that consuming a diet low in protein (0.9 g/kg/day), compared to the participants usual diet (1.5 g/kg/day), over 7 days, resulted in an increased insulin sensitivity as well as a marked increase in the plasma fibroblast growth factor 21 (FGF21) concentration. The increased insulin sensitivity is thought to be mediated by the increase in plasma FGF21 concentration. However, the effect is not yet fully understood. It is also not clear whether the increase in plasma FGF21 concentration, as well as the mentioned metabolic effects on insulin and glucose homeostasis, will take place if the participants are kept weight stable on a eucaloric diet. conditions: Protein conditions: Healthy conditions: Diet studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Longitudinal study changing diet during the intervention 5 weeks restricted dietary protein + 5 weeks habitual dietary protein consumption primaryPurpose: BASIC_SCIENCE masking: NONE count: 23 type: ACTUAL name: Dietary protein restriction measure: Energy balance measure: Insulin sensitivity measure: Adipose tissue proteomics measure: Plasma FGF21 sex: MALE minimumAge: 25 Years maximumAge: 35 Years stdAges: ADULT facility: University of Copenhagen city: Copenhagen zip: 2100 country: Denmark lat: 55.67594 lon: 12.56553 hasResults: False
nctId: NCT06267222 id: SCATDCS23 briefTitle: Trans-spinal Electrical Stimulation in Individuals With Spinocerebellar Ataxia overallStatus: ENROLLING_BY_INVITATION date: 2024-03-04 date: 2024-06-30 date: 2024-07-31 date: 2024-02-20 date: 2024-02-20 name: Laura Alice Santos Oliveira class: OTHER name: Federal Institute of Rio de Janeiro briefSummary: The main goal of this pragmatic clinical trial is to investigate the effects of trans-spinal tDCS in individuals with spinocerebellar ataxia (SCA) over some parameters of gait and postural control in real-world conditions, reflecting daily clinical practice. The main questions it aims to answer are:
* Postural control and gait of the participants will be assessed in two big sessions before (#assessment 1) and after the 20 sessions (#assessment 5) and 3 small sessions after every 5 sessions (#assessments 2, 3 and 4). Also, as a follow-up, they will be assessed a month after the end of the intervention (#assessment 6). conditions: SCA conditions: Postural Balance conditions: Gait Ataxia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This is a pragmatic clinical trial that will be carried out using the CONSORT-Pragmatic Trials (Zwarenstein et al., 2008). primaryPurpose: TREATMENT masking: NONE maskingDescription: THE INVESTIGATOR NOT BE INFORMED ABOUT THE TREATMENT count: 40 type: ESTIMATED name: TRANSCRANIAL DIRECT CURRENT STIMULATION + exercises measure: Postural control measure: Mobility measure: Gait performance measure: The subjective experience of the participants regarding the protocol. sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Anna Fontes Baptista city: Rio de Janeiro state: RJ zip: 21032-060 country: Brazil lat: -22.90278 lon: -43.2075 hasResults: False
nctId: NCT06267209 id: He-Modulation briefTitle: Conditioned Pain Modulation in Patients With Hemophilia overallStatus: NOT_YET_RECRUITING date: 2024-02-19 date: 2024-03-03 date: 2024-04-20 date: 2024-02-20 date: 2024-02-20 name: Investigación en Hemofilia y Fisioterapia class: NETWORK briefSummary: Introduction: Hemophilic arthropathy is characterized by functional alterations, disabling physical sequelae, and chronic pain. Conditioned pain modulation describes the net effect of endogenous pathways that enhance or diminish the effects of afferent noxious stimuli.
Objectives: To describe conditioned pain modulation in patients with hemophilia and identify the best predictive model of conditioned pain modulation in these patients Methods: Cross-sectional cohort study. 51 patients with hemophilic arthropathy will be recruited in 3 regions of Spain. The main study variable will be the conditional pain modulation (Conditioned Pain Modulation Index, using an ischemic technique of the arm using the pain pressure threshold as a test stimulus), with age being the dependent variable. The secondary variables, estimated as modifying or confounding variables, will be kinesiophobia (Tampa Scale for Kinesiophobia), catastrophizing (Pain Catstrophizing Scale), trait and state anxiety (State-Trait Anxiety Inventory) and the main clinical, anthropometric, and sociodemographic.
Expected results: Identify the degree of modulation conditioned by pain in patients with hemophilic arthropathy. Identify the best predictive model for conditioned pain modulation in these patients based on the study variables conditions: Hemophilia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 51 type: ESTIMATED name: Observational group measure: Assess the Conditioned Pain Modulation Index measure: Assess the kinesiophobia with Tampa Scale of Kinesiophofia measure: Assess the catastrophizing with Pain catastrophizing scale measure: Assess the catastrophizing with State-Trait Anxiety Inventory measure: Assess the joint damage with Haemophilia Joint Health Score measure: Assess the joint pain with visual analog scale measure: Assess the pressure pain threshold with pressure algometer measure: Assess the functional capacity with the 6-Minute Walking test sex: MALE minimumAge: 20 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Oviedo city: Oviedo state: Asturias zip: 33006 country: Spain name: Rubén Cuesta-Barriuso, PhD role: CONTACT lat: 43.36029 lon: -5.84476 hasResults: False
nctId: NCT06267196 id: CemilTascıogluERHO-AYAN briefTitle: The Effect of the Stress Ball Used During Spinal Anesthesia on Pain and Anxiety acronym: stressball overallStatus: RECRUITING date: 2023-11-02 date: 2024-03-02 date: 2024-03-15 date: 2024-02-20 date: 2024-02-20 name: Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization class: OTHER briefSummary: The aim is to determine the impact of the stress ball used during spinal anesthesia on pain and anxiety levels conditions: Pain conditions: Anxiety studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 140 type: ESTIMATED name: The use of a stress ball measure: stress ball and anxiety measure: stress ball and pain measure: Stress ball and blood pressure measure: Stress ball and pulse measure: Stress ball and saturation sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Özge Sayın Ayan status: NOT_YET_RECRUITING city: Istanbul state: Eyup zip: 34065 country: Turkey name: özge sayın role: CONTACT phone: +905332965628 email: ozgesayinayan@gmail.com name: volkan özen role: CONTACT phone: +905309276094 email: vozen81@gmail.com lat: 41.01384 lon: 28.94966 facility: Prof.Dr.Cemil Tascioglu City Hospital status: RECRUITING city: Istanbul state: Şişli zip: 34360 country: Turkey name: özge sayın ayan role: CONTACT phone: +905332965628 email: ozgesayinayan@gmail.com name: volkan özen role: CONTACT phone: +905309276094 email: vozen81@gmail.com lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06267183 id: SV001-101 briefTitle: A Clinical Study to Evaluate Safety, Tolerability and Pharmacokinetics of SV001 in Chinese Healthy Adult Volunteers. overallStatus: RECRUITING date: 2024-01-12 date: 2024-11-30 date: 2025-03-30 date: 2024-02-20 date: 2024-02-20 name: Shanghai Synvida Biotechnology Co.,Ltd. class: INDUSTRY briefSummary: The purpose of this study is to evaluate safety, tolerability, PK and immunogenicity of SV001 compare to placebo in Chinese healthy adult volunteers. conditions: Idiopathic Pulmonary Fibrosis studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 53 type: ESTIMATED name: SV001 name: Placebo measure: Incidence of Treatment-Emergent Adverse Events measure: Peak Plasma Concentration (Cmax) measure: Peak time（Tmax） measure: Area under the plasma concentration versus time curve (AUC) measure: half-life（T1/2） measure: Immunogenicity sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Shanghai Xuhui District Central Hospital status: RECRUITING city: Shanghai country: China name: Qian Chen role: CONTACT phone: 0086-021-54036058 email: qchen@shxh-centerlab.com lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06267170 id: SCLC-RWS-001 briefTitle: A Multicenter, Real-world Study of Adebrelimab in the Treatment of Extensive Stage Small Cell Lung Cancer acronym: SCLC overallStatus: NOT_YET_RECRUITING date: 2024-02-25 date: 2025-02-25 date: 2026-02-25 date: 2024-02-20 date: 2024-02-20 name: Henan Cancer Hospital class: OTHER_GOV briefSummary: This study collected data on patients with extensive stage small cell lung cancer treated with Adebrelimab to investigate its safety and efficacy conditions: SCLC,Extensive Stage studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 288 type: ESTIMATED name: Adebrelimab measure: Safety (Occurrence of ≥ Grade 3 AE) measure: PFS measure: ORR measure: OS measure: DCR sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06267157 id: 2023/23 briefTitle: Breastfeeding Consultant Training in the Metvaverse Universe overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2024-05-20 date: 2024-07-02 date: 2024-02-20 date: 2024-02-20 name: Gulhane School of Medicine class: OTHER briefSummary: Although breastfeeding is an important and natural process in infant development, mothers may fail to manage the process. Nurses, who have an important place in helping to physically initiate and maintain breastfeeding, provide an in-depth knowledge of breast anatomy and breastfeeding physiology, practice and process breastfeeding techniques. Must have extensive management skills. Although the World Health Organization recommends that breastfeeding issues should be addressed in medical, nursing and midwifery schools, there is a lack of nurses' training curricula and breastfeeding training given in hospitals. Due to this deficiency, mothers have low self-confidence and insufficient knowledge about breastfeeding.
The aim of this project is to develop a breastfeeding counseling model in the metaverse universe and to determine the effect of this model on nursing students' breastfeeding counseling skills, knowledge level and empathy skills. Giving breastfeeding education with the metaverse application compared to the application on real patients includes much less risk for the patient and the ability to practice until the right skill is acquired. In the project, it is expected that the breastfeeding counseling education model (LactaVerse), which is structured on virtual reality developed in the metaverse universe, is compared to the existing deficient and non-standardized breastfeeding education practice, enabling nurses to practice more and without errors during the undergraduate education, and to gain more effective skills in breastfeeding counseling. In this context, the project will support the ability of multiple users in the metaverse universe to examine the anatomy of the breast and apply breastfeeding counseling to the mother by transmitting their voices and movements with virtual glasses.
In the preparation phase of the training to be developed in the virtual universe within the scope of the project, the breast anatomical modeling and the breastfeeding mother-baby duo project scenario will be developed and virtual glasses will be transferred. At this stage, expert opinions of the questionnaires to be used in the evaluation of educational effectiveness will be taken. Pre-application of data collection tools and LactaVerse training will be made. Experiment (n=40) and control (n=40) groups will be determined from the students by randomization. "Descriptive Characteristics Data Collection Form", "Breastfeeding Information Form", "Basic Empathy Level Scale", "Nursing Counseling Skill Scale" and "Presence Scale" will be applied to both groups. During the application phase, Lactaverse training method with virtual glasses will be applied to the experimental group, and a 2-hour theoretical classical training method will be applied to the control group. After 4 weeks of the training, the post-tests will be applied to the experimental group and the control group and they counseling will be given to the patient who plays the role of a nursing mother in the laboratory, and measurements will be made with the Breastfeeding Counseling Skill List and statistical analyzes will be applied.
With the training developed in connection with the project, it is expected that nurses will have a high level of empathy development and breastfeeding counseling skills in a complex healthcare environment such as breastfeeding counseling before they graduate. In this way, the professional knowledge, counseling skills and empathy skills of nurses, who have an important role in breastfeeding, will increase, helping our society to increase the breastfeeding rates to the desired level. conditions: Breast Feeding studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 22 type: ESTIMATED name: virtual reality training name: theoretical breastfeeding training measure: Introductory Features Data Collection Form measure: Breastfeeding Information Form measure: Basic Empathy Level Scale measure: Breastfeeding Teaching Skill Evaluation Form measure: Presence Scale sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Gulhane Faculty of Nursing city: Ankara country: Turkey name: Gulten Guvenc role: CONTACT email: gulten.guvenc@sbu.edu.tr lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06267144 id: 23K237-001 briefTitle: Detection of Minimal Residual Disease in Resectable Stage II-IIIB Non-small Cell Lung Cancer overallStatus: RECRUITING date: 2024-01-20 date: 2025-06-01 date: 2025-12-17 date: 2024-02-20 date: 2024-02-20 name: The First Hospital of Jilin University class: OTHER briefSummary: Predicting relapse and overall survival in potentially resectable Stage IIIA-IIIB Non-small Cell Lung Cancer (NSCLC) patients remains challenging. It is now widely recognized that patients with detectable MRD have a worse prognosis than those with undetectable MRD. Therefore, investigators performed this prospective clinical trial to evaluate the predictive value of MRD with increased risk of relapse and improves prediction of outcome in potentially resectable Stage IIIA-IIIB NSCLC with neoadjuvant chemoimmunotherapy. In this study, investigators will pay more attention to the long-term follow-up time and dynamic monitoring of MRD. The predictive value of MRD with Disease-free survival (DFS) rate was observed as the primary endpoint. Besides that, the correlation of MRD with major pathologic response (MPR) rate, pathologic complete response (pCR) rate，event-free survival(EFS) rate and overall survival (OS) were observed as the second endpoints. Investigators hope it will provide a new insight for these potentially resectable Stage IIA-IIIB NSCLC with neoadjuvant chemoimmunotherapy. conditions: Lung Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED name: Sintilimab plus chemotherapy measure: Event free survival(EFS) measure: Overall Survival (OS) measure: Objective Response Rate (ORR) measure: Disease-Control Rate (DCR) measure: Pathological complete response rate（PCR） measure: Major pathological response rate (MPR) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The First Hospital Of Jilin University status: RECRUITING city: Changchun state: Jilin zip: 130000 country: China name: Ma Kewei role: CONTACT phone: 0431-88782222 lat: 43.88 lon: 125.32278 hasResults: False
nctId: NCT06267131 id: IRB 22-1286 briefTitle: Transcutaneous Pulse Oximetry Brain Monitoring Study (US) acronym: T-POT US overallStatus: RECRUITING date: 2023-10-27 date: 2024-11 date: 2024-11 date: 2024-02-20 date: 2024-02-20 name: Cyban Pty Ltd class: INDUSTRY briefSummary: This is a study of adult patients with a severe and sudden brain injury who have a drain placed in their brain to measure pressure. The purpose of the study is to monitor the pressure in the brain using a monitor placed on the forehead, and compare this to a drain placed in the brain. conditions: Acute Brain Injury studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single center prospective observational cohort study primaryPurpose: DIAGNOSTIC masking: NONE count: 15 type: ESTIMATED name: Brain Pulse Oximeter measure: Agreement of the brain oximeter levels compared with invasive ICP levels measure: Optical signal changes associated with periods of brain hypoxia and surrogate ICP waveform measure: Optical signal changes associated with non-convulsive seizures via EEG monitoring (Alpha, Beta, Theta) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cleveland Clinic, Neurological Institute status: RECRUITING city: Cleveland state: Ohio zip: 44195 country: United States name: Catherine Hassett, DO role: CONTACT phone: 216-445-1385 email: HASSETC@ccf.org name: Joao Gomes, MD role: CONTACT phone: 216-445-1385 email: GOMESJ@ccf.org lat: 41.4995 lon: -81.69541 hasResults: False
nctId: NCT06267118 id: Treatment of Bronchiolitis briefTitle: Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis acronym: children overallStatus: RECRUITING date: 2023-11-01 date: 2024-04-30 date: 2024-05-31 date: 2024-02-20 date: 2024-02-20 name: Combined Military Hospital, Pakistan class: OTHER briefSummary: The goal of this clinical trial is to compare the efficacy of hypertonic saline nebulization with adrenaline nebulization in the treatment of acute bronchiolitis in children. Main aim is to evaluate the following in both group of patients