hackint0sh/New-Dataset huggingface dataset:
The refinement of 3D-cultivation techniques, experienced in the last decade, has allowed cultivation of patients-derived cancer cells in organotypic structures, named patient-derived organoids (PDO), which preserve histologic, genomic and transcriptomic features of primary tumors. PDO allow propagation, pharmacological treatment and genetic manipulation of patients-derived cancer cells in a close to physiology setting, thus representing a promising tool in the development of personalized therapies conditions: Breast Cancer conditions: Organoids studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 306 type: ESTIMATED measure: evaluate the histological and molecular conformity (yes/no) between PDO and matched primary and/or recurrent BC sample, in order to develop a live biobank of ER/PR+, HER2+ and TNBC PDO. measure: evaluate the sensitivity of ER/PR+, HER2+ and TNBC PDO to novel therapeutic agents in clinical trials for BC or other cancer types measure: test the sensitivity of PDO to splicing-targeting treatments, either alone or in combination with other therapies measure: test the synergizing effects of agents splicing-targeting treatments to immunotherapies by co-culture experiments with autologous immune cells sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Fondazione Policlinico A. Gemelli status: RECRUITING city: Roma zip: 00168 country: Italy name: alba di leone, MD role: CONTACT phone: 0039 3474980503 email: alba.dileone@policlinicogemelli.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06315855 id: STUDY00006928 briefTitle: Leveraging Telehealth to Improve Oral Health Among Cancer Survivors overallStatus: NOT_YET_RECRUITING date: 2024-03-25 date: 2025-03-25 date: 2025-12-25 date: 2024-03-18 date: 2024-03-18 name: Georgetown University class: OTHER briefSummary: The investigators will conduct a 2-arm 6-month randomized clinical controlled trial to evaluate the effectiveness of an oral Telehealth Intervention (THI) in preventing cancer-related oral complications, improving oral health maintenance and oral health related quality of life, and reducing systemic inflammation compared to Usual Care (UC) among unselected cancer survivors. conditions: Oral Mucositis conditions: Periodontal Diseases conditions: Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 100 type: ESTIMATED name: Telehealth Intervention (THI) measure: mucositis measure: gingival inflammation and periodontal disease measure: tooth decay measure: oral health related quality of life measure: systemic inflammation measure: overall health related quality of life measure: comorbidities sex: ALL minimumAge: 25 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06315842 id: CSAPG-44 briefTitle: Levels of Diagnostic and Therapeutic Intervention in Hospitalized Patients acronym: NIT overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-07 date: 2025-07 date: 2024-03-18 date: 2024-03-18 name: Consorci Sanitari de l'Alt Penedès i Garraf class: OTHER briefSummary: The objective of this clinical trial is to investigate the impact of implementing a tool for adjusting the level of diagnostic and therapeutic intensity in the clinical practice of physicians attending hospitalized patients.
The goal of this clinical trial is to investigate the impact of a tool for adjusting diagnostic and therapeutic intensity in hospitalized patients. The main question it aims to answer is: Is there a difference in patient mortality when using the aforementioned tool? The participating physicians will be grouped into 4 groups (5 physicians each). Each group will progressively (every 3 months) incorporate the use of the aforementioned tool into their usual clinical practice. conditions: Acute Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: The participating physicians will be grouped into 4 clusters (5 physicians each). Each cluster will progressively (every 3 months) incorporate the use of a level of diagnostic and therapeutic intensity tool into their usual clinical practice. primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: Levels of Diagnostic and Therapeutic Intervention tool by Fontecha and col. name: Usual clinical practice measure: In-hospital Patient Mortality at 90 days from hospital discharge measure: In-hospital Patient Mortality at 6 months from hospital discharge measure: In-hospital Patient Mortality at 1 year from hospital discharge measure: Delirium Incidence measure: Pressure Ulcer Incidence measure: Hospital stay measure: Hospital readmission for any reason measure: Hospital readmission for same reason measure: Patients admitted to the Intensive Care Unit (ICU) measure: Calls to the "on-call doctor" measure: Healthcare expenditure measure: Mortality at ICU sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Consorci Sanitari Alt Penedes i Garraf city: Vilafranca Del Penedès state: Barcelona zip: 08720 country: Spain name: Helena Camell role: CONTACT phone: +34 938960025 phoneExt: 46048 email: hcamell@csapg.cat name: Noemí Casaponsa role: CONTACT phone: +34 938960025 phoneExt: 43197 email: recerca@csapg.cat lat: 41.34618 lon: 1.69713 hasResults: False
nctId: NCT06315829 id: IRB00429753 briefTitle: Artificial Intelligence-based Video Analysis to Detect Infantile Spasms overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-05 date: 2026-05 date: 2024-03-18 date: 2024-03-18 name: Johns Hopkins University class: OTHER briefSummary: Infantile spasms are a type of seizure linked to developmental issues. Unfortunately, they are often misdiagnosed, causing delays in treatment. The purpose of this study is to develop a computer program that can reliably differentiate infantile spasms from similar, yet benign movements in videos. This computer program will learn from videos taken by parents of study participants. Quickly recognizing and treating infantile spasms is crucial for ensuring the best developmental outcomes. conditions: Infantile Spasms studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 200 type: ESTIMATED name: Spasm Vision measure: Model Sensitivity (Recall) measure: Model Specificity measure: Model Positive Predictive Value (Precision) measure: Model Negative Predictive Value sex: ALL maximumAge: 2 Years stdAges: CHILD facility: Johns Hopkins Hospital city: Baltimore state: Maryland zip: 21287 country: United States name: Glenn Rivera, MD role: CONTACT phone: 410-955-4259 email: griver14@jh.edu lat: 39.29038 lon: -76.61219 hasResults: False
nctId: NCT06315816 id: DokuzEU-1 briefTitle: Virtual Reality Used During Tooth Extraction and Extirpation Treatment overallStatus: RECRUITING date: 2024-04-01 date: 2024-08-01 date: 2024-09-30 date: 2024-03-18 date: 2024-03-18 name: Murat Bektaş class: OTHER briefSummary: This study carriy out to evaluate the effect of virtual reality glasses used during tooth extraction and extirpation treatment under local anesthesia on anxiety and fear in children aged 7-10 years. conditions: Anxiety and Fear conditions: Tooth Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The population will consist of children between the ages of 7-10 who presented to the pediatric dental clinic of an oral and dental health center Turkey. The sample size of the study was calculated as GPOWER 3.1 statistical analysis software, based on a significance level of 0.05, a power value of 80%, and an effect size of 0.15 (medium effect size). Considering 10% attrition, it will plan to sample a total of 80 children, including 40 in the experimental group and 40 in the control group. Eventually, a total of 120 children, 60 in the experimental group and 60 in the control group,will include in the study to reveal the relationship between the variables more clearly. primaryPurpose: PREVENTION masking: SINGLE maskingDescription: The data will be analyzed by a statistician blind to the groups. whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: virtual reality glasses used during tooth extraction and extirpation treatment measure: Anxiety Means measure: Fear Means sex: ALL minimumAge: 7 Years maximumAge: 10 Years stdAges: CHILD facility: Hakkari University status: RECRUITING city: Hakkari state: Merkez country: Turkey name: Dilek Demir Kösem, PhD role: CONTACT phone: +9005534813290 email: dilekdemir624@gmail.com lat: 37.57444 lon: 43.74083 facility: Hakkari University status: RECRUITING city: Hakkari country: Turkey name: Dilek Demir Kösem, PhD role: CONTACT phone: +9005534813290 email: dilekdemir624@gmail.com lat: 37.57444 lon: 43.74083 hasResults: False
nctId: NCT06315803 id: ChinaPLAGH20230601 briefTitle: Randomized Controlled Clinical Study of Biplanar Ultrasound-guided Puncture of Lumbar Interforamen overallStatus: COMPLETED date: 2023-06-23 date: 2024-02-01 date: 2024-02-01 date: 2024-03-18 date: 2024-03-18 name: Yi Mao class: OTHER name: National Natural Science Foundation of China briefSummary: The goal of this clinical trial is to compare Xplane ultrasound with radiography for guidance of lumbar interforamen puncture in patients with lumbar disc herniation. The main question\[s\] it aims to answer are:
Participants will undergo lumbar interforamen puncture with guidance of Xplane ultrasound or radiography. If there is a comparison group: Researchers will compare the first success rate, number of punctures, number of radiographies, puncture time and operator confidence score. conditions: Lumbar Disc Herniation conditions: Percutaneous Endoscopic Lumbar Discectomy conditions: Three-dimension Ultrasound conditions: Learning Curves studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE maskingDescription: There are practical differences in operation and blind methods cannot be achieved. count: 76 type: ACTUAL name: Real-time 3D Xplane ultrasound measure: the first success rate measure: number of punctures measure: number of radiographies measure: puncture time measure: operator confidence score measure: operative time measure: incidence of puncture relevant complications measure: satisfaction of patients measure: visual analog scale of pain measure: Oswestry disability index measure: modified Macnab criteria type sex: ALL minimumAge: 16 Years maximumAge: 80 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Chinese PLA General Hospital city: Beijing state: Beijing zip: 100853 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06315790 id: TN BTX-A Trial briefTitle: Safety and Efficacy of Botulinum Toxin A in Patients With Trigeminal Neuralgia overallStatus: RECRUITING date: 2023-11-01 date: 2025-10-01 date: 2025-10-01 date: 2024-03-18 date: 2024-03-18 name: Henrik Schytz class: OTHER briefSummary: This is a double-blind randomized clinical trial comparing the pain reduction of individuals treated with BTX-A and placebo as well as evaluating possible changes in neuroinflammatory biomarkers. The trial lasts 16 weeks, with a 4-week baseline phase and a 12-week randomization phase. Four visits are planned: 1) Introduction and baseline data collection, 2) Medical evaluation and treatment assignment, 3) Follow-up with biomarker analysis, and 4) Trial conclusion interview. 80 participants will be included and randomized 1:1. conditions: Trigeminal Neuralgia studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Botulinum toxin A name: Isotonic saline measure: Proportion of responders in botulunim toxin A and placebo group measure: Biomarkers measure: Tear fluid CGRP measure: 50 % reduction measure: 75 % reduction measure: Prolonged 30 % reduction measure: Change in paroxysms measure: PGI-C measure: PENN Facial Pain Scale-Revised (PENN-FPS-R) measure: Patient's guess measure: Dropouts measure: Side effects measure: Pure paroxysmal pain vs. paroxysms with concomitant pain measure: Idiopathic vs. classical trigeminal neuralgia measure: Patients with severe pain measure: Gender distribution measure: Disease duration sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Danish Headache Center status: RECRUITING city: Glostrup zip: 2600 country: Denmark name: Henrik Schytz, MD role: CONTACT phone: +4528761824 email: henrik.winther.schytz.01@regionh.dkonh.dk name: Henrik Schytz, MD role: PRINCIPAL_INVESTIGATOR lat: 55.6666 lon: 12.40377 hasResults: False
nctId: NCT06315777 id: FRGS/1/2021/SKK01/UKM/02/1 briefTitle: GREM1, HAS2 and PTGS2 Gene Expression Following the in Vitro Maturation (IVM) overallStatus: RECRUITING date: 2021-07-01 date: 2024-07-01 date: 2024-07-31 date: 2024-03-18 date: 2024-03-18 name: National University of Malaysia class: OTHER briefSummary: Poor ovarian reserve (POR) is an adverse prognostic factor for In-Vitro Fertilization (IVF) success. Numerous established data showed low live birth rates per IVF cycle; 6 to 10%, including the usage of In-Vitro Maturation (IVM). In Malaysia, POR incidence increases mainly from cancer survival, endometriosis, and autoimmune diseases women; therefore, IVM implementation is paramount. In the molecular level, the low competence oocytes showed a low expression of GREM1, HAS2 and PTGS2 in human cumulus cells, thus leading to poor oocyte quality(OQ). Various IVM media had been formulated to enhance the competency and quality of the oocytes to date. Therefore, our study aims to elucidate the GREM1, HAS2 and PTGS2 gene expression as oocyte developmental competency markers among POR women following IVM and tailored to the IVF outcome. conditions: Increased Oocyte Death conditions: in Vitro Maturation conditions: GREM1 Gene Mutation conditions: Cumulus Cell studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 30 type: ESTIMATED name: cumulus cell oocytes complex (COC) among women with poor ovarian reserve measure: normal ovarian reserve measure: poor ovarian reserve sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Advanced Reproductive Centre status: RECRUITING city: Kuala Lumpur state: Wilayah Persekutuan Kuala Lumpur zip: 56000 country: Malaysia name: Muhammad Azrai AA Abu role: CONTACT phone: +60196410944 email: azraiabu1983@gmail.com lat: 3.1412 lon: 101.68653 hasResults: False
nctId: NCT06315764 id: Hypertensive patients briefTitle: Effect of the Reflexology on Insomnia Severity Index in Hypertensive Patients overallStatus: COMPLETED date: 2022-01-01 date: 2022-01-30 date: 2023-05-30 date: 2024-03-18 date: 2024-03-18 name: Cairo University class: OTHER briefSummary: In Egypt, there is a dearth of understanding of the benefits of reflexology and aerobic exercise on hypertension patients' quality of life. conditions: Hypertension studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Group (A):
This group consisted of twenty female patients suffering from hypertension who received the same drugs as group (A) as well as reflexology three times per week for eight weeks primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 40 type: ACTUAL name: Reflexology measure: Insomnia severity index measure: Short form 36 quality of life questionnaire (SF-36): measure: Blood pressure measurements: sex: FEMALE minimumAge: 35 Years maximumAge: 45 Years stdAges: ADULT facility: Heba Mousa city: Cairo zip: 11517 country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06315751 id: NOE-TTS-201 briefTitle: Efficacy and Safety of Gemlapodect in Adults and Adolescents With Tourette Syndrome acronym: Allevia2 overallStatus: NOT_YET_RECRUITING date: 2024-05-31 date: 2026-12-31 date: 2026-12-31 date: 2024-03-18 date: 2024-03-18 name: Noema Pharma AG class: INDUSTRY briefSummary: This study is designed to evaluate the efficacy and safety of gemlapodect (NOE-105) on reducing tics associated with Tourette Syndrome (TS) in adults with TS. Adolescents will be enrolled after a sentinel cohort of adults is complete. conditions: Tourette Syndrome studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 180 type: ESTIMATED name: Gemlapodect name: Placebo measure: Change in tic severity score on the Revised Yale Global Tic Scoring Scale (YGTSS-R) measure: Impact on patient functioning measure: Change in PUTS measure: Safety and Tolerability of gemlapodect measure: Assessment of suicidality and suicidal ideation sex: ALL minimumAge: 12 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06315725 id: 2024-10504 briefTitle: Effect of Artificial Sweetener (AFS) on Glucose Metabolism in Patients With Type 1 Diabetes (T1D) acronym: AFS_T1D overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2025-09-01 date: 2027-09-01 date: 2024-03-18 date: 2024-04-16 name: McGill University Health Centre/Research Institute of the McGill University Health Centre class: OTHER briefSummary: The goal of this randomized crossover study is to test the prediction that consuming carbohydrates will affect insulin release differently depending on whether Non-Nutritive Sweeteners (NNSs) are consumed simultaneously. We aim to determine whether the predicted effects are associated with oral or post-oral sweet taste receptor signaling,. Our study will focus on patients diagnosed with type 1 diabetes (T1D) who are using an artificial pancreas (AP) system, as it allows us to monitor glucose and insulin levels over time.
Sucralose will be used as the NNS, maltodextrin as the carbohydrate, and Gymnema Sylvestre (GS) as the sweet taste receptor blocker. conditions: Type 1 Diabetes (T1D) conditions: Healthy Subjects studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: OTHER count: 25 type: ESTIMATED name: Sweet taste perception with/without sweet taste blockade measure: Effectiveness and optimal time course of sweet test blockade on sweet taste perception in healthy individuals measure: Mean plasma glucose, basal and bolus insulin changes in individuals with T1D on AP following beverage consumption. measure: Resting Energy Expenditure (REE) and nutrient partitioning changes in individuals with T1D on AP following beverage consumptionT1D on AP following beverage consumption sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT hasResults: False
nctId: NCT06315712 id: 004201 briefTitle: Inspiratory Muscle Training in Burned Adults acronym: Burns overallStatus: COMPLETED date: 2021-01-15 date: 2022-06-16 date: 2023-09-11 date: 2024-03-18 date: 2024-03-18 name: Qassim University class: OTHER name: Cairo University briefSummary: The study outlines burn injury impact, emphasizes need for long-term rehabilitation. Study assesses inspiratory muscle training efficacy in improving respiratory strength, lung function, and exercise capacity in adult burn patients. conditions: Burn Injuries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 52 type: ACTUAL name: inspiratory exercise name: Pulmonary rehabilitation measure: maximal inspiratory pressure measure: maximal inspiratory pressure measure: maximal expiratory pressure measure: maximal expiratory pressure measure: Forced expiratory volume in 1 second measure: Forced expiratory volume in 1 second measure: forced vital capacity measure: forced vital capacity measure: Forced expiratory volume in 1 second/ forced vital capacity ratio measure: Forced expiratory volume in 1 second/ forced vital capacity ratio measure: Functional exercise capacity measure: Functional exercise capacity sex: ALL minimumAge: 20 Years maximumAge: 49 Years stdAges: ADULT facility: Faculty of Physical Therapy, Cairo University city: Giza state: Dokki zip: 11432 country: Egypt lat: 30.00808 lon: 31.21093 hasResults: False
nctId: NCT06315699 id: QL000001 id: MR-37-24-002019 type: REGISTRY domain: Chinese Clinical Trial Registry briefTitle: Clemastine Fumarate in the Treatment of Neurodevelopmental Delays in Williams Syndrome overallStatus: RECRUITING date: 2024-03-20 date: 2025-03-02 date: 2025-12-30 date: 2024-03-18 date: 2024-03-18 name: Qilu Hospital of Shandong University class: OTHER briefSummary: This study focuses on therapeutic targets for cognitive, motor, and social impairments in Williams syndrome by reversing brain myelin defects caused by GTF2I. The primary objective of the study was to test and evaluate the initial efficacy and safety of Clomastine fumarate in the treatment of Williams syndrome. conditions: Williams Syndrome conditions: Child conditions: Neurodevelopmental Delay studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 50 type: ESTIMATED name: Clemastine Fumarate Tablets name: fructose measure: Anisotropy Score (FA) measure: Radial diffusion rate (RD) measure: Apparent dispersion coefficient（ADC） measure: Magnetization transfer ratio（MTR） measure: SRS Score 2(Social Response Scale2) score measure: Peabody（Motion Estimation Timewarp）score measure: Gesell Development Scale measure: Differential pressure across valves measure: Thyroid hormone value measure: Conners Parent Symptoms Questionnaire Score measure: Vailand-3 scale measure: CSHQ Children's Sleep Habits Questionnaire Score sex: ALL minimumAge: 3 Years maximumAge: 6 Years stdAges: CHILD facility: Qilu Hospital of Shandong University status: RECRUITING city: Tainan state: Shangdong zip: 250012 country: China name: cao aihua role: CONTACT phone: +18560086317 email: xinercah@163.com name: Liu zhiyue role: CONTACT phone: 15665785296 email: mikeydrakon8@gmail.com hasResults: False
nctId: NCT06315686 id: MA-ENDO-202209 briefTitle: The Dynamic Monitoring of Cerebrospinal Fluid ctDNA overallStatus: RECRUITING date: 2022-09-29 date: 2024-07-31 date: 2024-12-31 date: 2024-03-18 date: 2024-03-18 name: Jiangsu Province Nanjing Brain Hospital class: OTHER briefSummary: Focusing on advanced EGFR mutation in NSCLC patients with leptomeningeal metastasis, vormetinib combined with OMMAYA lateral ventricle chemotherapy (pemetrexed) was used to dynamically monitor ctDNA in cerebrospinal fluid (CSF), analyze the ctDNA gene mutation profile of CSF in different patients, and explore the relationship between ctDNA and efficacy and prognosis. conditions: NSCLC studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: pemetrexed measure: The progression-free survival time（PFS） measure: Incidence of Treatment-Emergent Adverse Events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Nanjing Brain Hospital status: RECRUITING city: Suzhou state: Jiangsu zip: 210029 country: China name: fang S Cun, M.D. role: CONTACT phone: 83728558 phoneExt: 025 email: fang1984@aliyun.com name: fang S cun role: CONTACT phone: 83728558 email: fang1984@aliyun.com lat: 31.30408 lon: 120.59538 hasResults: False