hackint0sh/New-Dataset huggingface dataset:
A blood sample will be taken to establish a lipid profile in all patients. We will thus gain a better understanding of the changes in lipid and protein content in the vitreous humour, sub-retinal fluid and retina, and the demonstration of a link between the initial presentation and the postoperative anatomical and functional evolution of retinal detachment. This will provide a better understanding of the lipid-dependent mechanisms linked to inflammation and photoreceptor degeneration during retinal detachment, and will ultimately make it possible to develop new therapeutic strategies to improve visual prognosis. conditions: Rhegmatogenous Retinal Detachments studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 160 type: ESTIMATED name: Blood sampling name: vitreous sampling name: Sub-retinal fluid sampling name: Retinal tissue sampling measure: Molecular content of fatty acids and proteins in the vitreous humour of eyes operated on for retinal detachment and eyes operated on for macular surgery sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chu Dijon Bourgogne city: Dijon zip: 21000 country: France name: Petra EID role: CONTACT phone: 0380295173 phoneExt: +33 email: petra.eid@chu-dijon.fr lat: 47.31667 lon: 5.01667 hasResults: False
nctId: NCT06347289 id: CHSD_0024_REA briefTitle: Refusal of Organ Donation: a Study of Psychological, Anthropological and Cultural Factors overallStatus: COMPLETED date: 2022-01-01 date: 2023-04-30 date: 2024-03-29 date: 2024-04-04 date: 2024-04-04 name: Centre Hospitalier de Saint-Denis class: OTHER name: Agence de La Biomédecine briefSummary: The Hospital of Saint Denis (HSD) has been involved for several years in the dynamics of organ donation. In spite of the evolution of the practices of coordination of the collection of samples, the rate of refusal of organ donation is increasing in our hospital, contrary to the rest of France.
Based on hypotheses derived from psychological and anthropological perspectives, this survey will provide first-hand information on the personal, family and cultural issues related to organ donation. It will be a question of identifying and locating individual and collective representations concerning death, its definition, and the associated symbols and rites. Based on the collection of these representations, we will be able to propose hypotheses of a psychological, social and anthropological nature on resistance to organ donation. conditions: Psychology conditions: Anthropology conditions: Refusal, Organ Donation studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 100 type: ACTUAL measure: Demographic information measure: Demographic information measure: Demographic information measure: Demographic information sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre Hopitalier de Saint-Denis city: Saint-Denis state: Seine Saint Denis zip: 93200 country: France lat: 48.93326 lon: 2.36666 hasResults: False
nctId: NCT06347276 id: 2023-RW320-08 briefTitle: Cerebral Microembolization Associated With PFO Closure overallStatus: RECRUITING date: 2024-01-01 date: 2024-12-31 date: 2024-12-31 date: 2024-04-04 date: 2024-04-04 name: China National Center for Cardiovascular Diseases class: OTHER_GOV briefSummary: This study aims to investigate (1) the de novo cerebral microembolization in patients who undergo transcatheter closure of PFO or ASD, and (2) evaluate the relationship between de novo cerebral microembolization and in situ thrombus within PFO. conditions: Thrombosis Cardiac studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 90 type: ESTIMATED name: PFO occluder; ASD occluder measure: De novo cerebral microembolization sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chaowu Yan status: RECRUITING city: Beijing state: Beijing zip: 100037 country: China name: Chaowu Yan, PhD and MD role: CONTACT phone: +861088398408 email: chaowuyan@163.com name: Chaowu Yan, PhD and MD role: PRINCIPAL_INVESTIGATOR lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06347263 id: PER 332 briefTitle: Clinical and Radiographic Evaluation of Using the Entire Papilla Preservation Technique With and Without Autogenous Bone Graft and Injectable Platelet Rich Fibrin in Treatment of Periodontal Intraosseous Defects overallStatus: RECRUITING date: 2024-04 date: 2025-04 date: 2025-04-30 date: 2024-04-04 date: 2024-04-04 name: Cairo University class: OTHER briefSummary: The goal of this Clinical trial is to evaluate the clinical and radiographic outcomes of using entire papilla preservation technique with and without autogenous bone and injectable platelet rich fibrin in treatment of isolated Intrabony defects in patients with stage III periodontitis. conditions: Isolated Intrabony Periodontal Defects in Patients With Periodontitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Blinding of the operator and patient is not applicable.
- Outcome assessor (primary and secondary outcomes) \& biostatistician will be blinded whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: Entire papilla preservation technique measure: Clinical attachment level (CAL) gain change from baseline to 12 months measure: Linear bone fill change from baseline to 12 months sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Faculty of dentistry, Cairo University status: RECRUITING city: Cairo zip: 3753450 country: Egypt name: Nesma M Shemias, Ass Lecturer role: CONTACT email: nesma.shemais@dentistry.cu.edu.eg name: Manal M Hosny, Professor role: CONTACT email: manal.hosny@dentistry.cu.edu.eg lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06347250 id: SGB-Bulbar Palsy briefTitle: A Nerve Block Therapy for Bulbar Palsy Pharyngeal Dysphagia overallStatus: COMPLETED date: 2022-01-01 date: 2023-05-02 date: 2023-05-31 date: 2024-04-04 date: 2024-04-04 name: Babujinaya Cela class: OTHER_GOV briefSummary: This was a multicenter randomized controlled study. 66 post-stroke patients with pharyngeal dysphagia were randomly allocated to the observation group or the control group. Both groups were provided with comprehensive rehabilitation including routine rehabilitation and swallowing function training. Besides, the observation group additionally underwent the stellate ganglion block (SGB). At admission and after 20-day treatment,Yale Pharyngeal Residue Severity Rating Scale, video fluoroscopic swallowing study (VFSS), Functional Oral Intake Scale, and Rosenbek penetration-aspiration scale (PAS) were used to assess swallowing function. conditions: Bulbar Palsy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 122 type: ACTUAL name: Nerve Block name: Lidocaine Hydrochloride name: routine therapy name: placebo block measure: The Functional Oral Intake Scale measure: Yale Pharyngeal Residue Severity Rating Scale measure: penetration-aspiration scale measure: Video fluoroscopic swallowing study measure: The Swallowing Quality of Life Questionnaire sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ZhenD No.1 Hos. city: Zhenzhou country: China lat: 32.28034 lon: 119.16999 hasResults: False
nctId: NCT06347237 id: NL84429.078.23 briefTitle: PsA Digital Phenotyping and Inflammation Drivers Study acronym: PDPID overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-12 date: 2025-12 date: 2024-04-04 date: 2024-04-04 name: Jolanda Luime class: OTHER name: University of Oxford - Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences name: Aristotle University of Thessaloniki - Hipokrateion Hospital Thessaloniki name: Portuguese Society of Rheumatology - The Rheumatic Diseases Portuguese Registry (Reuma.pt) briefSummary: The goal of this observational study is to develop and internally validate a machine learning model for detecting flare using a digital biomarker and a machine learning model for predicting flare, in patients with psoriatic arthritis. The main questions it aims to answer are:
* Collect biological material conditions: Psoriatic Arthritis conditions: Flare Up, Symptom conditions: Psoriatic Arthritis Aggravated studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 600 type: ESTIMATED measure: Absence of flare in patients measure: Minimal disease Activity (MDA) measure: Psoriatic Arthritis Disease Activity Score (PASDAS) measure: Disease Activity Psoriatic Arthritis (DAPSA) measure: Psoriatic Arthritis Impact of Disease (PsAID) measure: Morning stiffness measure: Keystroke dynamics measure: Screen time measure: Accelerometer data measure: Gyroscope sensor data measure: Steps count measure: Physical activity intensity and categories measure: Motion measure: Distance measure: Pulse Ox measure: Respiration measure: Body battery measure: Stress (digital) measure: Heart rate measure: Beat-to-beat intervals measure: Sleeping time measure: Sleeping type measure: Hand and feet photos measure: Hand and body movements videos measure: Medical history measure: Joint count measure: Enthesitis measure: Body surface area measure: Weight measure: Height measure: Abdominal circumference measure: ClASsification criteria for Psoriatic ARthritis (CASPAR) score measure: Demographics measure: VAS Pain measure: HAQ questionnaire measure: VAS patient global measure: PSAID questionnaire measure: SF-36 questionnaire measure: EQ5d questionnaire measure: Work Productivity and Activity Impairment (WPAI) questionnaire measure: Health care questionnaire measure: Patient Health Questionnaire (PHQ9) questionnaire measure: Perceived Stress Scale (PSS) measure: Global Rating of Change (GRoC) Scale measure: Life events questionnaire measure: Digital literacy questionnaire measure: Inflammatory blood marker measure: Genetic variants measure: Gut microbiome measure: Stress (cortisol levels) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06347224 id: BCFC-BCS-VIRTUAL2024 briefTitle: Both Column Fixation Corridor in Pelvic Surgery overallStatus: COMPLETED date: 2023-10-01 date: 2024-02-01 date: 2024-03-01 date: 2024-04-04 date: 2024-04-04 name: Bakirkoy Dr. Sadi Konuk Research and Training Hospital class: OTHER_GOV briefSummary: The concepts of the Both Column Fixation Corridor (BCFC) and Both Column Screws (BCS) have emerged as innovative approaches in orthopedic surgery yet have not been extensively explored in the literature. This study aims to evaluate the feasibility and potential advantages of this novel screw fixation technique, thereby filling the existing gap in knowledge and establishing standards for its application. conditions: Acetabular Fractures studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: CROSSOVER primaryPurpose: SCREENING masking: SINGLE whoMasked: PARTICIPANT count: 400 type: ACTUAL name: Virtual placement of lag screws in both columns of the acetabulum on 3D pelvic CT models. measure: Successful Visualization of Both Column Fixation Corridor (BCFC) and Placement of Both Column Screws (BCS) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bakırköy Dr. Sadi Konuk Education and Research Hospital, Department of Orthopedics and Traumatology city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06347211 id: Attikon Hospital briefTitle: "Hypotension Probability Indicator" in TAVI/MitraClip for Hypotension Management overallStatus: RECRUITING date: 2024-01-10 date: 2026-01-10 date: 2026-01-10 date: 2024-04-04 date: 2024-04-05 name: Attikon Hospital class: OTHER briefSummary: The study will investigate whether the use of Goal Directed Hemodynamic Therapy implemented with the HPI algorithm using a treatment algorithm will reduce the incidence of hypotension and improve treatment of hypotension. conditions: Hypotension During Surgery conditions: Prevention of Hypotension studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Acumen IQ sensor with Hemosphere monitor incorporating the HPI algorithm measure: TWA hypotension (measured with Acumen IQ sensor) measure: Incidence of hypotension measure: Time spent in hypotension measure: Treatment choice (drugs/fluids) measure: Diagnostic guidance protocol deviations sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Attikon Hospital status: RECRUITING city: Athens zip: 12462 country: Greece name: Orestis Milionis role: CONTACT phone: +306948333359 email: Orestismilionis@gmail.com name: Orestis Milionis role: PRINCIPAL_INVESTIGATOR name: Tatiana Sidiropoulou role: PRINCIPAL_INVESTIGATOR lat: 37.97945 lon: 23.71622 hasResults: False
nctId: NCT06347198 id: 20230807-02 briefTitle: Oral Inulin in Combination With Fruquintinib Plus Sintilimab as Third- or Further-line Treatment in Metastatic Colorectal Cancer overallStatus: RECRUITING date: 2024-04-10 date: 2024-12-01 date: 2025-05-01 date: 2024-04-04 date: 2024-04-04 name: Wuhan Union Hospital, China class: OTHER name: Huazhong University of Science and Technology briefSummary: This is a single-center exploratory clinical study to explore the efficacy and safety of Oral Inulin in Combination With Fruquintinib Plus Sintilimab as Third- or Further-line Treatment in Metastatic Colorectal Cancer. conditions: Metastatic Colorectal Cancer studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Fruquintinib name: Sintilimab name: Inulin measure: Intestinal microbiota diversity, abundance and taxonomic information measure: adverse events measure: Objective remission rate (ORR) measure: Overall survival (OS) measure: Progression-free survival (PFS) measure: Disease control rate (DCR) measure: Duration of remission (DOR) measure: Concentration of various serum metabolites measure: Concentration of various plasma Cytokine Changes measure: Frequency of peripheral blood lymphocyte measure: Correlation between dietary fiber intake and progression-free survival sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Min Jin status: RECRUITING city: Wuhan state: Hubei zip: 430030 country: China name: Min Jin role: CONTACT phone: 18807108606 email: minjin86@126.com lat: 30.58333 lon: 114.26667 hasResults: False
nctId: NCT06347185 id: EORTC-2236-HNCG-QLG briefTitle: Simultaneous Care in Recurrent and/or Metastatic Head and Neck Cancer: the SupCare Study acronym: SupCare overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2027-04 date: 2028-12 date: 2024-04-04 date: 2024-04-04 name: European Organisation for Research and Treatment of Cancer - EORTC class: NETWORK briefSummary: This is a late phase II, prospective, multicenter randomized study, to assess the value of early palliative care integrated with the standard oncologic care in patients with Recurrent Metastatic (RM) Head and Neck Cancer (HNC) proposed to first line palliative systemic treatment.
Standard of Care: the oncologist will be the main referral of the patient, deciding the therapeutic approach, the assessments requested, in terms of type of exams and timing and the need of possible further support from other expertise. The oncologist will base the choices also upon the results of the Liverpool Head and Neck Patient Concern Inventory (PCI-H\&N) and the patient's preferences. At the end of the first oncological visit, the physician will be asked to predict the survival of the patient.
Integrated approach: Besides the Oncology visit, patient will have the palliative care expert visit and follow up. The oncologist will define the therapeutic approach and the assessments requested, in terms of type of exams and timing. The palliative care clinician and the oncologist will judge the burden of symptoms and together they will propose the suggested interventions to relief the symptoms, with a particular attention to a validated instrument (the PCI-H\&N) and patient priority questionnaire's results.
End of study occurs when all patients have completed their end of study visit and the study is mature for all analyses defined in the protocol and the database has been cleaned and frozen for these analyses. conditions: Head and Neck Neoplasms studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 160 type: ESTIMATED name: Early palliative care, integrated with the standard oncologic care (proactive approach) name: Palliative care requested as needed, integrated with the standard oncologic care (reactive approach) measure: Change from baseline in emotional functioning and pain scores according to Item List (IL) 250 questionnaire at 15 weeks. measure: Change from baseline in emotional functioning and pain scores according to Item List 250 (IL250) questionnaire at 6 weeks, 24 weeks and 52 weeks. measure: Change from baseline in the selected Health Related Quality of Life (HRQoL) scales from the Item List 250 (IL250) questionnaire at 6 weeks, 15 weeks, 24 weeks and 52 weeks measure: Number of unplanned visits to emergency room or specialist visits measure: Hospitalization due to treatment toxicities or tumour signs/symptoms, as evaluated by number of admissions and duration measure: Identification of the rate of patients starting a new systemic treatment in the last three months of life measure: Rate of patients receiving systemic treatment in the last month of life measure: Rate of patients with a tracheostomy performed in the last 3 months of life measure: Rate of patients with gastrostomy performed in the last 3 months of life measure: Caregiver/family members' satisfaction (FAMcare questionnaire) at 15 weeks measure: Overall Survival (OS) measure: Prediction error of survival (defined as the difference between actual survival (AS) of patients and clinician prediction of survival (CPS)) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06347172 id: 2024p000278 id: U54AG063546 type: NIH link: https://reporter.nih.gov/quickSearch/U54AG063546 briefTitle: Deprescribing in Patients Living With Dementia With Caregiver and Provider Nudges overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2024-11-15 date: 2025-01-15 date: 2024-04-04 date: 2024-04-04 name: Brigham and Women's Hospital class: OTHER name: Brown University name: National Institute on Aging (NIA) briefSummary: The objectives of this study are to demonstrate the feasibility of implementing a deprescribing nudge intervention using pragmatic methods, confirm that outcomes can be feasibly measured and evaluated at scale in a subsequent embedded pragmatic clinical trial (ePCT), and explore representativeness of persons living with dementia and care partners identified. conditions: Alzheimer Disease conditions: Mild Cognitive Impairment conditions: Dementia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 360 type: ESTIMATED name: Nudge Intervention measure: Composite of the percentage of eligible PCPs or their PLWD/care partners who view or click on information measure: Number of nudges that fire as intended: Fidelity measure: Discontinuation or prescribed reduction in medication sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT hasResults: False
nctId: NCT06347159 id: EDG-7500-102 briefTitle: A Study of EDG-7500 in Adult Patients With Obstructive Hypertrophic Cardiomyopathy (CIRRUS-HCM) overallStatus: RECRUITING date: 2024-04 date: 2025-03 date: 2025-03 date: 2024-04-04 date: 2024-04-04 name: Edgewise Therapeutics, Inc. class: INDUSTRY briefSummary: This study is being conducted in order to understand the safety and effects of different doses of EDG-7500 either as a single or multiple dose in adult patients with obstructive hypertrophic cardiomyopathy. conditions: Hypertrophic Cardiomyopathy studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: EDG-7500 name: EDG-7500 measure: Incidence of treatment-emergent adverse events measure: Change from baseline in left ventricular outflow tract (LVOT) gradient measure: Pharmacokinetic parameters of EDG-7500 as measured by maximum plasma concentration (Cmax) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine) status: RECRUITING city: Philadelphia state: Pennsylvania zip: 19104 country: United States name: Edgewise Therapeutics, Inc. role: CONTACT lat: 39.95233 lon: -75.16379 hasResults: False
nctId: NCT06347146 id: R01HD112323 type: NIH link: https://reporter.nih.gov/quickSearch/R01HD112323 id: R01HD112323 type: NIH link: https://reporter.nih.gov/quickSearch/R01HD112323 briefTitle: Bridges2Scale: Testing Implementation Strategies overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2028-03-31 date: 2028-07-31 date: 2024-04-04 date: 2024-04-04 name: Washington University School of Medicine class: OTHER name: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) briefSummary: The goal of this clinical trial is to compare two multifaceted strategies (standard vs enhanced) for scaling Bridges in a two-arm Hybrid III effectiveness-implementation cluster randomized controlled trial (RCT) in adolescent and youths affected by AIDS \[AYaAIDS\] (ages 13-17 years) from 48 schools in the Greater Masaka region of Uganda. The main aims of the clinical trial are: Aim 1. Compare the implementation effectiveness of the standard implementation strategy vs. an enhanced implementation strategy. The investigators will assess fidelity to Bridges (primary implementation outcome) and sustainment of Bridges (exploratory implementation outcome).
Aim 2. Determine the clinical effectiveness of Bridges implemented via a standard vs. enhanced implementation strategy. Aim 3: Explore implementation processes, mechanisms, and determinants. Aim 4. Compare the cost and cost-effectiveness of the two implementation strategies. Using an activity-based ingredients approach, the investigators will examine how much each strategy costs to achieve a unit of effect. conditions: HIV/AIDS studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 1440 type: ESTIMATED name: Financial Literacy Training (FLT) workshops name: Mentorship name: Income Generation Activity (IGA) name: Youth Development Accounts (YDA) measure: Intervention Fidelity measure: HIV prevalence measure: Sexual risk-taking behavior measure: Economic stability measure: School attainment measure: Depressive Symptoms measure: Proportion of adolescents living with HIV who are virally suppressed measure: Proportion of HIV negative adolescents who use PrEP measure: Hopelessness measure: Self-Esteem measure: Self-concept sex: ALL minimumAge: 13 Years maximumAge: 17 Years stdAges: CHILD hasResults: False