hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06314152 id: 2023032 briefTitle: 3-point With 1-point Mesh Fixation in TAPP for Inguinal Hernia overallStatus: RECRUITING date: 2023-01-01 date: 2024-10-10 date: 2024-10-10 date: 2024-03-15 date: 2024-03-20 name: Nanchong Central Hospital class: OTHER_GOV name: Guang'an People's Hospital name: Pengan County People's Hospital name: People's Hospital of Yilong County name: Nanbu Hospital of County Chinese Medicine name: Langzhong People's Hospital name: Langzhong Traditional Chinese Medicine Hospital briefSummary: This study was designed to compare the outcome of 3 point with 1 point lightweight mesh fixation in TAPP surgery for patients with inguinal hernia. The main outcome include seroma, chronic pain, recurrence, et al. conditions: Inguinal Hernia conditions: Chronic Pain conditions: Seroma conditions: Recurrent conditions: Infections conditions: Hematoma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 337 type: ESTIMATED name: Lightweight mesh fixation in 3 points or 1 point measure: Rate of recurrence measure: Rate of postoperative pain measure: Rate of postoperative complications sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Yunhong Tian status: RECRUITING city: Nanchong state: Sichuan zip: 637000 country: China name: Yunhong Tian, PHD role: CONTACT phone: 13508087719 email: drtianyunhong@126.com lat: 30.79508 lon: 106.08473 hasResults: False
nctId: NCT06314139 id: YanmingXu001 briefTitle: Tolerability and Efficacy of Continuous Theta-burst Stimulation for Essential Tremor: A Randomized Study. overallStatus: COMPLETED date: 2022-09-01 date: 2023-04-06 date: 2023-06-01 date: 2024-03-15 date: 2024-03-15 name: West China Hospital class: OTHER briefSummary: Essential tremor (ET) is one of the most common movement disorders in adults. The prevalence rate among the elderly over 65 years old is about 4.6%. Tremor usually worsens with age, leading to disability and loss of independence, which has an adverse impact on the quality of life of patients. However, the traditional first-line treatment drugs are neither effective enough nor completely safe for ET patients. Although surgical procedures such as deep brain stimulation (DBS) and thalamotomy can be used to better control unilateral limb tremor, many patients are reluctant to choose surgical treatment because it's invasive. Therefore, there is an urgent need to develop new drugs or non-invasive therapies as a better treatment option for ET.
Continuous theta burst stimulation (cTBS) is one of the non-invasive electrophysiological techniques characterized by plexus stimulation, which is similar to low-frequency repetitive transcranial magnetic stimulation (rTMS) but closer to the physiological state of neural activity, and may inhibit the excitability of the stimulated cortex. The stimulation duration is greatly shortened, which is simpler and easier than the low-frequency rTMS of 20-30 minutes. In addition, functional near infrared spectroscopy (fNIRS) is a new non-invasive functional neuroimaging technique. It mainly uses the difference characteristics of oxyhemoglobin and deoxyhemoglobin in brain tissue for near-infrared light absorption at different wavelengths of 600-900nm. The efficacy, safety, and mechanisms involved in non-invasive stimulation therapy for ET patients are still unclear. There are few studies on the treatment of ET with cTBS, and the sample size is small (the largest sample includes only 23 ET patients). Additionally, there was a lack of exploration on the therapeutic mechanism of cTBS for ET patients. Therefore, the investigators conducted a double-blind, randomized, sham-controlled clinical trial to evaluate the safety and efficacy of cTBS in the treatment of ET patients over both cerebellar and cortical area. conditions: Essential Tremor conditions: Continuous Theta Burst Stimulation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ACTUAL name: continuous theta-burst stimulation (cTBS) measure: Tremor assessment using Fahn-Tolosa-Marin (FTM) tremor-rating scales measure: Clinical global impression-improvement (CGI-I) rating scores measure: Electrophysiological evaluation of cortical excitability and inhibition measured by TMS. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province 610041, P.R. China. city: Chengdu state: Sichuan Sheng zip: 610041 country: China lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06314126 id: ENDO-DCI briefTitle: Evaluation of D-Chiro-Inositol Treatment in Women With Endometriosis acronym: ENDO-DCI overallStatus: RECRUITING date: 2024-01-01 date: 2025-01 date: 2025-04 date: 2024-03-15 date: 2024-03-15 name: University of Palermo class: OTHER briefSummary: To date, the treatment for endometriosis is represented by the surgical removal of the lesions. Nonetheless, in the years following surgery, the lesions can recur, often due to excessive estrogen production. To balance estrogen, progestin- or estrogen-progestin-based medications are generally prescribed. On the other hand, progestins and estrogen-progestins act as contraceptives, preventing the onset of a pregnancy. At the same time, these can have side effects that can affect up to 30% of patients. For these and other reasons, some women refuse therapy with progestins or estrogen-progestins, preferring to resort to no treatment.
D-Chiro-Inositol (DCI) is a polyol normally present in human cell membranes, where, from a metabolic point of view, it acts as a second messenger of insulin, while from a hormonal point of view, it exerts an on the biosynthesis of androgens. This effect on steroidogenesis can be attributed to more than one mechanism. In the ovary, DCI stimulates direct testosterone production. Furthermore, it stimulates the accumulation of testosterone by reducing the activity of the aromatase enzyme, responsible for the conversion of androgens into estrogens. Considering the responsiveness of endometriosis to estrogens, and that these constitute a risk factor for recurrences following surgical removal, the use of DCI could be interesting from a clinical point of view.
The study plans to verify whether D-Chiro-Inositol dietary supplementation can be effective in reducing systemic estrogen levels in women with endometriosis, thus also reducing the risk of relapses and associated symptoms. conditions: Endometriosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized placebo-controlled trial primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: Participants and investigators will be masked to the treatment allocation. Treatment pills and placebo pills will be the same in shape, taste, color, and size. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 32 type: ESTIMATED name: D-Chiro-Inositol name: Placebo measure: Estradiol measure: Pelvic pain sex: FEMALE minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: "Paolo Giaccone" Hospital status: RECRUITING city: Palermo zip: 90127 country: Italy name: Antonio Simone Laganà, M.D., Ph.D. role: CONTACT name: Pietro Serra, M.D. role: SUB_INVESTIGATOR name: Giuseppe Mascellino, M.D. role: SUB_INVESTIGATOR name: Andrea Etrusco, M.D. role: SUB_INVESTIGATOR lat: 38.13205 lon: 13.33561 hasResults: False
nctId: NCT06314113 id: EGCG-HPV briefTitle: Evaluation of Oral EGCG Treatment for L-SIL Associated With HPV Infection acronym: EGCG-HPV overallStatus: RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-09-01 date: 2024-03-15 date: 2024-03-15 name: University of Palermo class: OTHER briefSummary: The study aims to evaluate the effectiveness of the synergy of oral Epigallocatechin Gallate as a treatment for Low-grade Cervical Lesions (L-SIL) associated with Human Papilloma Virus (HPV) infection. conditions: Low-Grade Intraepithelial Neoplasia of Cervix studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 50 type: ESTIMATED name: Epigallocatechin Gallate measure: Persistence sex: FEMALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: "Paolo Giaccone" Hospital status: RECRUITING city: Palermo zip: 90127 country: Italy name: Antonio Simone Laganà, M.D., Ph.D. role: CONTACT phone: +39 3296279579 email: antoniosimone.lagana@unipa.it name: Giuseppe Mascellino, M.D. role: SUB_INVESTIGATOR name: Pietro Serra, M.D. role: SUB_INVESTIGATOR name: Andrea Etrusco, M.D. role: SUB_INVESTIGATOR lat: 38.13205 lon: 13.33561 hasResults: False
nctId: NCT06314100 id: IP-2020-02-4027-EB briefTitle: The Effect of Aerosol Formed From Tobacco Heating Systems on the Microbiome of Supragingival Dental Biofilm overallStatus: COMPLETED date: 2021-10-01 date: 2023-10-25 date: 2023-10-25 date: 2024-03-15 date: 2024-03-15 name: University of Rijeka class: OTHER name: Croatian Science Foundation briefSummary: Dental caries is a multifactorial disease primarily caused by supragingival dental biofilm. Its progression is influenced by many environmental factors, which include smoking. Tobacco heating systems (THS) are a novel tobacco product whose effect on the microbiome of the supragingival dental biofilm has not yet been investigated.
The results of this research will provide insight into changes in the microbiome of the supragingival dental biofilm resulting from exposure to aerosols from tobacco combustion and tobacco heating. conditions: Dental Caries studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 60 type: ACTUAL name: Tobacco heating systems name: cigarette smoking name: non smoking measure: diversity of bacterial species measure: abundance of bacterial species measure: caries risk sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of dental medicine, University of Rijeka city: Rijeka country: Croatia lat: 45.32674 lon: 14.44239 hasResults: False
nctId: NCT06314087 id: Neoantigen Radiotherapy briefTitle: iTAPVR Study - Phase II Randomized Study overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-08 date: 2026-08 date: 2024-03-15 date: 2024-03-15 name: The University of Hong Kong-Shenzhen Hospital class: OTHER briefSummary: In this study, the investigators provide an individualized tumor neoantigen peptide vaccine in combination with radiotherapy to patients with advanced malignant solid tumors. The investigators observe the post-treatment tumor burden status, the immune response induced by immune preparations, and the prolongation of patient survival time, aiming to evaluate the effectiveness and safety of the individualized tumor neoantigen peptide vaccine in combination with radiotherapy conditions: Advanced Tumors studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE maskingDescription: Randomized count: 154 type: ESTIMATED name: Placebo + conventional treatment including radiotherapy name: Radiation: Radiation Therapy；Biological: Personalized tumor peptide vaccine measure: Progression free survival sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06314074 id: 2023-101143-BO-ff briefTitle: 2.5 Versus 5 Minutes Trial overallStatus: RECRUITING date: 2024-03-12 date: 2025-03 date: 2025-04 date: 2024-03-15 date: 2024-04-01 name: Universitätsklinikum Hamburg-Eppendorf class: OTHER briefSummary: This is a randomized trial investigating the effect of oscillometric blood pressure monitoring at 2.5-minute intervals - compared to 5-minute intervals - on intraoperative hypotension. Specifically, the investigators will test the primary hypothesis that oscillometric blood pressure monitoring at 2.5-minute intervals - compared to 5-minute intervals - reduces the time-weighted average mean arterial pressure below 65 mmHg in patients having non-cardiac surgery. conditions: Hypotension studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE whoMasked: PARTICIPANT count: 264 type: ESTIMATED name: Oscillometric blood pressure monitoring at 2.5-minute intervals name: Oscillometric blood pressure monitoring at 5-minute intervals measure: Time-weighted average mean arterial pressure <65 mmHg measure: Episodes of a mean arterial pressure <50 mmHg measure: Norepinephrine dose sex: ALL minimumAge: 45 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf status: RECRUITING city: Hamburg zip: 20246 country: Germany name: Karim Kouz, Dr role: CONTACT phone: +49 40 7410 52415 email: k.kouz@uke.de lat: 53.57532 lon: 10.01534 hasResults: False
nctId: NCT06314061 id: WARD-glucose RCT v.2.2 briefTitle: The Effect of Continuous Glucose Monitoring in Surgical Patients With Diabetes. acronym: WARD-glucose overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-07-01 date: 2026-01-01 date: 2024-03-15 date: 2024-03-15 name: Christian S. Meyhoff class: OTHER name: Rigshospitalet, Denmark name: Steno Diabetes Center Copenhagen name: Zealand University Hospital briefSummary: The goal of this randomised controlled trial to investigate the effect of continuous glucose monitoring (CGM) compared to standard point-of-care (POC) blood glucose measurements in surgical patients with diabetes in patients.
Participants will be asked to wear a CGM device (Dexcom G7, Dexcom Inc.) during their stay in the hospital. For patients in the intervention group, deviations of glucose levels will provide the nursing staff with alerts. All patients will receive standard care of their diabetes. The CGM device will be worn for up to 10 days or until discharge. conditions: Diabetes Mellitus conditions: Dysglycemia conditions: Perioperative Complication studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Parallel, 2-group randomised trial blinded for participants primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Participants will not be alerted of dysglycaemia by the Dexcom G7 application, which will be muted. Thus, the alerts on deviating glucose levels will only be given to the care provider (the nursing staff at the ward) whoMasked: PARTICIPANT count: 200 type: ESTIMATED name: Dexcom G7 Continuous Glucose Monitoring (CGM) System (G7) measure: Time in range (TIR) of CGM glucose levels measure: Duration of hypoglycaemia measure: Duration of hyperglycaemia measure: Number of hypoglycaemia events measure: Number of hyperglycaemia events measure: Complications measure: Serious adverse events measure: Serious adverse Device-related events measure: Adverse events measure: Length of stay measure: Readmission measure: ICU admission measure: Days alive and out of hospital measure: Patient experience measure: Staff experience sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Anaesthesiology, Centre for Cancer and Organ Diseases, Rigshospitalet city: Copenhagen state: The Capital Region Of Denmark zip: 2100 country: Denmark lat: 55.67594 lon: 12.56553 facility: Department of Anaesthesiology and Intensive Care, Bispebjerg Hospital city: Copenhagen state: The Capital Region Of Denmark zip: 2400 country: Denmark lat: 55.67594 lon: 12.56553 facility: Zealand University Hospital city: Køge zip: 4600 country: Denmark name: Annelotte Philipsen, MD, PhD role: CONTACT email: annph@regionsjaelland.dk lat: 55.45802 lon: 12.18214 hasResults: False
nctId: NCT06314048 id: 74212 briefTitle: 4T Sustainability Program overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-01 date: 2026-01 date: 2024-03-15 date: 2024-04-15 name: Stanford University class: OTHER briefSummary: The goal of the 4T program is to implement proven methods and emerging diabetes technology into clinical practice to sustain tight glucose control from the onset of type 1 diabetes (T1D) and optimize patient-reported and psychosocial outcomes. The investigators will expand the 4T (Teamwork, Targets, Technology, and Tight Control) program to all patients seen at Stanford Pediatric Diabetes Endocrinology as the standard of care. Disseminating the 4T program as the standard of care will optimize the benefits of diabetes technology by lowering HbA1c, improving PROs, and reducing disparities. conditions: Type1diabetes studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: 1. Implement the 4T program as standard of care at Stanford Diabetes clinics, including Continuous Glucose Monitoring (CGM) and Remote Patient Monitoring (RPM) within the first 30 days after T1D diagnosis to reduce the rise in HbA1c trajectory observed 4-12 months post-diagnosis.
3. Continue the systematic screening for patient-reported outcomes, both assessment of PROs and delivery of care linked to screening as a core component of the 4T program. primaryPurpose: OTHER masking: NONE count: 5000 type: ESTIMATED name: CGM and RPM measure: HbA1c trajectory observed 4-12 months post-diagnosis measure: Diabetes distress measured at baseline and 12 months post-diagnosis. sex: ALL minimumAge: 6 Months maximumAge: 21 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06314035 id: CIC2023003 briefTitle: Decision Support on End-of-life Care Planning in Older Adults overallStatus: NOT_YET_RECRUITING date: 2024-03-10 date: 2024-12-31 date: 2025-01-31 date: 2024-03-15 date: 2024-03-18 name: National Taipei University of Nursing and Health Sciences class: OTHER name: Chinese University of Hong Kong briefSummary: This study aims to test the effects of a patient decision aid (PDA) on planning for end-of-life (EOL) care among older adults with COPD. The main questions it aims to answer are:
Researchers will compare the intervention group to the control group to see if the PDA is better at improving the decision-making process on EOL care, the readiness of a person to join ACP communication and the chance to make an advance directive. conditions: Chronic Obstructive Pulmonary Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE maskingDescription: Participants will be blinded to their group assignment. The personnel administering the interventions will not be blinded whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: COPD Patient Decision Aid name: General Health Coaching Intervention measure: Patients' decisional conflict regarding EOL care measure: Patients' confidence level regarding three ACP actions - namely, appointing a surrogate and discussing EOL care with a surrogate and medical doctors. measure: Patients' readiness for ACP measure: Participant's completion of an Advance Directive (AD) measure: Participants' understanding of the PDA measure: Participant's subjective clarity of content, comfort during reading and viewing, and the usefulness of the information of the PDA. measure: Semi-structured Interviews sex: ALL minimumAge: 50 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06314022 id: 22-PI113 briefTitle: A Mobile Application to Improve the Quality of Colonoscopy in Colorectal Cancer Screening Program (PrepColon APP) acronym: PREPCOLON overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2025-12-30 date: 2025-12-30 date: 2024-03-15 date: 2024-03-18 name: Hospital del Río Hortega class: OTHER briefSummary: Colonoscopy is the gold standard for the diagnosis and resection of preneoplastic lesions, allowing the prevention of colon cancer. A colonoscopy is more efficient with proper preparation of the colon, as it allows for a higher rate of adenoma detection and cecal intubation. In routine practice, up to 30% of colonoscopies are poorly prepared and 11% of patients do not show up for their appointment. Adenomas not visualized in the initial colonoscopy due to poor preparation reached 68% and the rate of undetected cancers was 66.7%. A proper colon cleanse is conditioned by different factors; among them, failure to comply with the diet and take laxatives poses 5 times the risk of having a deficient colon preparation. The purpose of our study is the design and implementation of an app that facilitates the preparation of colonoscopy and evaluates its impact on compliance with diet and laxative intake. conditions: Colorectal Cancer conditions: Premalignant Colon Lesions studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Each subject will be randomized into two groups according to the instructions given to perform the preparation of the colon prior to colonoscopy: group A: perform the preparation with the written instructions delivered in the consultation and group B: they will be given the instructions in writing and will also be indicated how to install the APP. primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: Patients who agree to participate in the study are randomized by a 1:1 block computer program (an attempt will be made to balance the groups according to the type of laxative) into two groups: group A: control group, which receives the standard information given in writing, and group B: APP group, which receives the standard information together with the mobile application individually adapted to the scheduled colonoscopy appointment and the type of laxative.
Patients scheduled for a screening colonoscopy will be contacted by telephone, those who agree to participate will be scheduled with the nurse, after giving their consent they are randomized. Group B will indicate how to download the APP and its management. The endoscopist performing the examination is blind for randomization and will assess colon cleansing according to the Boston Bowel Scale (Lai EJ. et al Gastroinest Endosc 2009). whoMasked: INVESTIGATOR count: 470 type: ESTIMATED name: Mobile application for colonoscopy preparation instructions measure: Compliance with the diet and intake of laxatives with the use of a mobile application measure: Evaluate the quality of colon cleansing with mobile application as an experimental factor measure: Assessment of the usability of the APP measure: Compliance with the laxative intake with the use of the mobile application measure: Assessment of the difficulty of the preparation instructions measure: Evaluate colonoscopy quality indicators: measure: Evaluate attendance at the scheduled colonoscopy appointment measure: Evaluate colonoscopy quality indicators sex: ALL minimumAge: 50 Years maximumAge: 69 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Universitario Rio Hortega city: Valladolid zip: 47012 country: Spain lat: 41.65518 lon: -4.72372 hasResults: False