Site visits will take place at 2-, 4-, 8-, and 16- weeks following randomisation. Thereafter visits will occur approximately every 4 months, until the 24-month visit at which time baxdrostat/placebo will be discontinued. Participants will continue open-label dapagliflozin for another 6-weeks (approximately), where reassessment of GFR will occur for the primary efficacy endpoint. In the event of premature discontinuation of blinded study intervention, participants will continue in the study and receive open-label dapagliflozin monotherapy, unless the participant meets dapagliflozin specific discontinuation criteria, in which case all study interventions will be discontinued. conditions: Chronic Kidney Disease and Hypertension studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Placebo controlled whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 2500 type: ESTIMATED name: Baxdrostat/dapagliflozin name: Dapagliflozin in combination with placebo measure: To determine whether baxdrostat/dapagliflozin is superior to dapagliflozin alone to slow CKD progression, assessed as the effect on change in eGFR over time. measure: To determine whether baxdrostat/dapagliflozin is superior to dapagliflozin alone at reducing UACR (urine albumin-creatinine ratio). measure: To determine whether baxdrostat/dapagliflozin is superior to dapagliflozin alone at reducing SBP. measure: To determine whether baxdrostat/dapagliflozin compared with dapagliflozin alone slows CKD progression and reduces the risk of ESKD (End-stage kidney disease). measure: To determine whether baxdrostat/dapagliflozin compared with dapagliflozin alone slows the rate of kidney function decline after the hemodynamically-mediated acute effect on GFR (Glomerular Filtration Rate). sex: ALL minimumAge: 18 Years maximumAge: 130 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Research Site status: NOT_YET_RECRUITING city: Fairhope state: Alabama zip: 36532 country: United States lat: 30.52297 lon: -87.90333 facility: Research Site status: NOT_YET_RECRUITING city: Phoenix state: Arizona zip: 85016 country: United States lat: 33.44838 lon: -112.07404 facility: Research Site status: NOT_YET_RECRUITING city: Surprise state: Arizona zip: 85374 country: United States lat: 33.63059 lon: -112.33322 facility: Research Site status: NOT_YET_RECRUITING city: Searcy state: Arkansas zip: 72143 country: United States lat: 35.25064 lon: -91.73625 facility: Research Site status: NOT_YET_RECRUITING city: Beverly Hills state: California zip: 90211 country: United States lat: 34.07362 lon: -118.40036 facility: Research Site status: NOT_YET_RECRUITING city: Canyon Country state: California zip: 91351 country: United States lat: 34.42333 lon: -118.47203 facility: Research Site status: RECRUITING city: Fullerton state: California zip: 92835 country: United States lat: 33.87029 lon: -117.92534 facility: Research Site status: NOT_YET_RECRUITING city: Huntington Park state: California zip: 90255 country: United States lat: 33.98168 lon: -118.22507 facility: Research Site status: RECRUITING city: Lincoln state: California zip: 95648 country: United States lat: 38.89156 lon: -121.29301 facility: Research Site status: NOT_YET_RECRUITING city: Los Alamitos state: California zip: 90720 country: United States lat: 33.80307 lon: -118.07256 facility: Research Site status: NOT_YET_RECRUITING city: San Francisco state: California zip: 94110 country: United States lat: 37.77493 lon: -122.41942 facility: Research Site status: NOT_YET_RECRUITING city: Stanford state: California zip: 94305 country: United States lat: 37.42411 lon: -122.16608 facility: Research Site status: RECRUITING city: Tarzana state: California zip: 91356 country: United States lat: 34.17334 lon: -118.55397 facility: Research Site status: NOT_YET_RECRUITING city: Torrance state: California zip: 90502 country: United States lat: 33.83585 lon: -118.34063 facility: Research Site status: NOT_YET_RECRUITING city: Arvada state: Colorado zip: 80002 country: United States lat: 39.80276 lon: -105.08748 facility: Research Site status: NOT_YET_RECRUITING city: Denver state: Colorado zip: 80230 country: United States lat: 39.73915 lon: -104.9847 facility: Research Site 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48202 country: United States lat: 42.33143 lon: -83.04575 facility: Research Site status: NOT_YET_RECRUITING city: Pontiac state: Michigan zip: 48341 country: United States lat: 42.63892 lon: -83.29105 facility: Research Site status: NOT_YET_RECRUITING city: Saint Joseph state: Michigan zip: 49085 country: United States lat: 42.10976 lon: -86.48002 facility: Research Site status: NOT_YET_RECRUITING city: Columbia state: Missouri zip: 65201 country: United States lat: 38.95171 lon: -92.33407 facility: Research Site status: NOT_YET_RECRUITING city: Kansas City state: Missouri zip: 64111 country: United States lat: 39.09973 lon: -94.57857 facility: Research Site status: NOT_YET_RECRUITING city: Kansas City state: Missouri zip: 64128 country: United States lat: 39.09973 lon: -94.57857 facility: Research Site status: NOT_YET_RECRUITING city: Kansas City state: Missouri zip: 64151 country: United States lat: 39.09973 lon: -94.57857 facility: Research Site status: NOT_YET_RECRUITING city: 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United States lat: 39.84967 lon: -75.35707 facility: Research Site status: NOT_YET_RECRUITING city: Langhorne state: Pennsylvania zip: 19047 country: United States lat: 40.17455 lon: -74.92267 facility: Research Site status: RECRUITING city: Uniontown state: Pennsylvania zip: 15401 country: United States lat: 39.90008 lon: -79.71643 facility: Research Site status: NOT_YET_RECRUITING city: East Providence state: Rhode Island zip: 02914 country: United States lat: 41.81371 lon: -71.37005 facility: Research Site status: NOT_YET_RECRUITING city: East Providence state: Rhode Island zip: 02915 country: United States lat: 41.81371 lon: -71.37005 facility: Research Site status: NOT_YET_RECRUITING city: Providence state: Rhode Island zip: 02904 country: United States lat: 41.82399 lon: -71.41283 facility: Research Site status: NOT_YET_RECRUITING city: Columbia state: South Carolina zip: 29203 country: United States lat: 34.00071 lon: -81.03481 facility: Research Site status: NOT_YET_RECRUITING city: Sioux Falls state: South Dakota zip: 57103 country: United States lat: 43.54997 lon: -96.70033 facility: Research Site status: NOT_YET_RECRUITING city: Kingsport state: Tennessee zip: 37660 country: United States lat: 36.54843 lon: -82.56182 facility: Research Site status: NOT_YET_RECRUITING city: Memphis state: Tennessee zip: 38105 country: United States lat: 35.14953 lon: -90.04898 facility: Research Site status: NOT_YET_RECRUITING city: Memphis state: Tennessee zip: 38115 country: United States lat: 35.14953 lon: -90.04898 facility: Research Site status: RECRUITING city: Arlington state: Texas zip: 76015 country: United States lat: 32.73569 lon: -97.10807 facility: Research Site status: NOT_YET_RECRUITING city: Austin state: Texas zip: 78751 country: United States lat: 30.26715 lon: -97.74306 facility: Research Site status: NOT_YET_RECRUITING city: Dallas state: Texas zip: 75230 country: United States lat: 32.78306 lon: -96.80667 facility: Research Site status: 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facility: Research Site status: NOT_YET_RECRUITING city: Yambol zip: 8600 country: Bulgaria lat: 42.48333 lon: 26.5 facility: Research Site status: NOT_YET_RECRUITING city: Vancouver state: British Columbia zip: V6Z 1Y6 country: Canada lat: 49.24966 lon: -123.11934 facility: Research Site status: NOT_YET_RECRUITING city: Winnipeg state: Manitoba zip: R2V 3M3 country: Canada lat: 49.8844 lon: -97.14704 facility: Research Site status: NOT_YET_RECRUITING city: Halifax state: Nova Scotia zip: B3H 1V7 country: Canada lat: 44.64533 lon: -63.57239 facility: Research Site status: NOT_YET_RECRUITING city: Sydney state: Nova Scotia zip: B1P 1P3 country: Canada lat: 46.13511 lon: -60.1831 facility: Research Site status: NOT_YET_RECRUITING city: Brampton state: Ontario zip: L6S 0C6 country: Canada lat: 43.68341 lon: -79.76633 facility: Research Site status: NOT_YET_RECRUITING city: Concord state: Ontario zip: L4K 4M2 country: Canada lat: 43.80011 lon: -79.48291 facility: Research Site status: 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Research Site status: NOT_YET_RECRUITING city: Beijing zip: 100035 country: China lat: 39.9075 lon: 116.39723 facility: Research Site status: NOT_YET_RECRUITING city: Beijing zip: 100191 country: China lat: 39.9075 lon: 116.39723 facility: Research Site status: NOT_YET_RECRUITING city: Beijing zip: 102218 country: China lat: 39.9075 lon: 116.39723 facility: Research Site status: NOT_YET_RECRUITING city: Changsha zip: 410013 country: China lat: 28.19874 lon: 112.97087 facility: Research Site status: NOT_YET_RECRUITING city: Changzhou zip: 272100 country: China lat: 31.77359 lon: 119.95401 facility: Research Site status: NOT_YET_RECRUITING city: Chengdu zip: 610041 country: China lat: 30.66667 lon: 104.06667 facility: Research Site status: NOT_YET_RECRUITING city: Chengdu zip: 610072 country: China lat: 30.66667 lon: 104.06667 facility: Research Site status: NOT_YET_RECRUITING city: Chongqing zip: 402260 country: China lat: 29.56278 lon: 106.55278 facility: Research Site status: NOT_YET_RECRUITING city: Chuangchun zip: 130041 country: China facility: Research Site status: NOT_YET_RECRUITING city: Dongguan zip: 523009 country: China lat: 23.01797 lon: 113.74866 facility: Research Site status: NOT_YET_RECRUITING city: Foshan zip: 528000 country: China lat: 23.02677 lon: 113.13148 facility: Research Site status: NOT_YET_RECRUITING city: Guangzhou zip: 510630 country: China lat: 23.11667 lon: 113.25 facility: Research Site status: NOT_YET_RECRUITING city: Guangzhou zip: 510800 country: China lat: 23.11667 lon: 113.25 facility: Research Site status: NOT_YET_RECRUITING city: Guiyang zip: 550004 country: China lat: 26.58333 lon: 106.71667 facility: Research Site status: NOT_YET_RECRUITING city: Hangzhou zip: 310014 country: China lat: 30.29365 lon: 120.16142 facility: Research Site status: NOT_YET_RECRUITING city: Hengyang zip: 50012 country: China lat: 26.88946 lon: 112.61888 facility: Research Site status: NOT_YET_RECRUITING city: Huai'an zip: 223300 country: China 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43.60426 lon: 1.44367 facility: Research Site status: NOT_YET_RECRUITING city: Tours zip: 37000 country: France lat: 47.38333 lon: 0.68333 facility: Research Site status: NOT_YET_RECRUITING city: Valenciennes zip: 59300 country: France lat: 50.35 lon: 3.53333 facility: Research Site status: NOT_YET_RECRUITING city: Vandoeuvre les Nancy zip: 54511 country: France lat: 48.65 lon: 6.18333 facility: Research Site status: NOT_YET_RECRUITING city: Aachen zip: 52074 country: Germany lat: 50.77664 lon: 6.08342 facility: Research Site status: NOT_YET_RECRUITING city: Amberg zip: 92224 country: Germany lat: 49.44287 lon: 11.86267 facility: Research Site status: NOT_YET_RECRUITING city: Bad Oeynhausen zip: 32545 country: Germany lat: 52.20699 lon: 8.80365 facility: Research Site status: NOT_YET_RECRUITING city: Berlin zip: 12203 country: Germany lat: 52.52437 lon: 13.41053 facility: Research Site status: NOT_YET_RECRUITING city: Berlin zip: 13187 country: Germany lat: 52.52437 lon: 13.41053 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133.78333 facility: Research Site status: NOT_YET_RECRUITING city: Matsuyama-city zip: 790-0024 country: Japan lat: 33.83916 lon: 132.76574 facility: Research Site status: NOT_YET_RECRUITING city: Naka zip: 311-0113 country: Japan lat: 36.05 lon: 140.16667 facility: Research Site status: NOT_YET_RECRUITING city: Nishinomiya-Shi zip: 662-0918 country: Japan lat: 34.71562 lon: 135.33199 facility: Research Site status: NOT_YET_RECRUITING city: Obihiro-shi zip: 080-0848 country: Japan lat: 42.91722 lon: 143.20444 facility: Research Site status: NOT_YET_RECRUITING city: Oita-shi zip: 870-0033 country: Japan lat: 33.23333 lon: 131.6 facility: Research Site status: NOT_YET_RECRUITING city: Osaka-shi zip: 553-0003 country: Japan lat: 34.69374 lon: 135.50218 facility: Research Site status: NOT_YET_RECRUITING city: Osaka zip: 553-0003 country: Japan lat: 34.69374 lon: 135.50218 facility: Research Site status: NOT_YET_RECRUITING city: Sapporo zip: 064-8570 country: Japan lat: 43.06667 lon: 141.35 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