nctId: NCT06316960 id: AVACBFKIT briefTitle: Safety and Efficacy of Avapritinib in Relapsed or Refractory Pediatric CBF-AML With KIT Mutation overallStatus: RECRUITING date: 2024-03 date: 2026-03 date: 2027-03 date: 2024-03-19 date: 2024-03-19 name: Children's Hospital of Soochow University class: OTHER briefSummary: The purpose of this study is to evaluate the efficacy and safety of avapritinib in relapsed or refractory pediatric core binding factor acute myeloid leukemia with KIT mutation. conditions: AML, Childhood conditions: Relapse/Recurrence conditions: Refractory AML conditions: Core Binding Factor Acute Myeloid Leukemia conditions: C-KIT Mutation studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: Avapritinib name: Azacitidine Injection name: Decitabine Injection name: Idarubicin Hydrochloride name: Cytarabine name: Granulocyte Colony-Stimulating Factor measure: Composite remission rate (CRc) measure: Overall survival measure: Progression-free survival sex: ALL maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: First Affiliated Hospital Of University of Science and Technology of China status: NOT_YET_RECRUITING city: Hefei state: Anhui zip: 230000 country: China name: Chun Li, MD,PhD role: CONTACT phone: +86-13865992676 email: lichun1230@sohu.com lat: 31.86389 lon: 117.28083 facility: The Second Hospital of Anhui Medical University status: NOT_YET_RECRUITING city: Hefei state: Anhui zip: 230000 country: China name: Ninglin Wang, MD role: CONTACT phone: +86-13721113063 email: zwnltt@126.com lat: 31.86389 lon: 117.28083 facility: Guangzhou Women and Children Medical Center status: NOT_YET_RECRUITING city: Guangzhou state: Guangdong zip: 510000 country: China name: Hua Jiang, MD, PhD role: CONTACT phone: +86-13533330985 email: jiang_hua18@sina.cn lat: 23.11667 lon: 113.25 facility: The First Affiliated Hospital of Guangxi Medical University status: NOT_YET_RECRUITING city: Nanning state: Guangxi zip: 530000 country: China name: Ning Liao, MD role: CONTACT phone: +86-13978812808 email: ln12808@163.com lat: 22.81667 lon: 108.31667 facility: Kaifeng Children's Hospital status: NOT_YET_RECRUITING city: Kaifeng state: Henan zip: 475000 country: China name: Jixia Luo, MD role: CONTACT phone: +86-13592146539 email: luojixia@163.com lat: 34.7986 lon: 114.30742 facility: The First Affiliated Hospital of Zhengzhou University status: NOT_YET_RECRUITING city: Zhengzhou state: Henan zip: 450052 country: China name: Yufeng Liu, MD,PhD role: CONTACT phone: +86-13673666608 email: lyf6012@126.com lat: 34.75778 lon: 113.64861 facility: Third Xiangya Hospital of Central South University status: NOT_YET_RECRUITING city: Changsha state: Hunan zip: 410000 country: China name: Minghua Yang, MD role: CONTACT phone: +86-13973135843 email: yamahua123@163.com lat: 28.19874 lon: 112.97087 facility: XiangYa Hospital Central South University status: NOT_YET_RECRUITING city: Changsha state: Hunan zip: 410008 country: China name: Liangchun Yang, MD,PhD role: CONTACT phone: +86-13974927514 email: yangliangchung@163.com lat: 28.19874 lon: 112.97087 facility: Children's Hospital of Soochow University status: RECRUITING city: Suzhou state: Jiangsu zip: 215000 country: China name: Shaoyan Hu, MD, PhD role: CONTACT phone: +86-13771835430 email: hsy139@126.com name: Li Gao, MD role: CONTACT phone: +86-15821963190 email: joygaoli@163.com name: Shaoyan Hu, MD, PhD role: PRINCIPAL_INVESTIGATOR name: Peifang Xiao, MD role: PRINCIPAL_INVESTIGATOR name: Li Gao, MD role: SUB_INVESTIGATOR name: Jun Lu, MD role: SUB_INVESTIGATOR name: Jie Li, MD role: SUB_INVESTIGATOR lat: 31.30408 lon: 120.59538 facility: Xuzhou Children's Hospital status: NOT_YET_RECRUITING city: Xuzhou state: Jiangsu zip: 221000 country: China name: Qi An, MD role: CONTACT phone: +86-13814422329 email: anqi1974@sina.com lat: 34.18045 lon: 117.15707 facility: Qilu Hospital of Shandong University status: NOT_YET_RECRUITING city: Jinan state: Shandong zip: 250000 country: China name: Xiuli Ju, MD,PhD role: CONTACT phone: +86-13869192944 email: shellysdcn@hotmail.com lat: 36.66833 lon: 116.99722 facility: Children's Hospital Of Fudan University status: NOT_YET_RECRUITING city: Shanghai state: Shanghai zip: 200000 country: China name: Xiaowen Zhai, MD, PhD role: CONTACT phone: +86-18017590808 email: zhaixiaowendy@163.com lat: 31.22222 lon: 121.45806 hasResults: False