hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06327737 id: AKDENIZ-KAEK-916 briefTitle: Diabetic Ketoacidosis Diagnosis and Management overallStatus: COMPLETED date: 2020-12-15 date: 2022-11-15 date: 2023-03-15 date: 2024-03-25 date: 2024-03-25 name: Akdeniz University class: OTHER name: Ceren Kahraman briefSummary: This is the first and only study conducted on the use of capnography in children diagnosed with DKA to evaluate the initial clinical grading of DKA, monitor clinical improvement, and predict complications such as brain edema. conditions: Metabolic Acidosis conditions: Diabetic Ketoacidosis conditions: Brain Edema studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 55 type: ACTUAL name: Capnography measure: Correlation between PCO2 and EtCO2 measure: Correlation between Integrated Pulmonary Index and degree of acidosis measure: Prediction of cerebral edema with Integrated Pulmonary Index sex: ALL minimumAge: 15 Days maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Akdeniz University city: Antalya country: Turkey lat: 36.90812 lon: 30.69556 hasResults: False
nctId: NCT06327724 id: 12434 briefTitle: Belimumab in SLE Synovial Inflammation and Lymph Nodes overallStatus: RECRUITING date: 2023-09-01 date: 2025-01-01 date: 2025-03-01 date: 2024-03-25 date: 2024-03-25 name: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) class: OTHER name: GlaxoSmithKline briefSummary: Systemic lupus erythematosus (SLE)is an immune-mediated inflammatory disease (IMIDs) of which the cellular and molecular alterations of the immune system driving the diseases still remains largely unknown. Accordingly, it remains difficult to predict the individual patient's response to treatment. Moreover, the patient's response to treatment remains heterogeneous and difficult to predict, despite the development of a variety of novel and powerful drugs (including the so-called biologicals). Therefore, there is a clear need for the identification and validation of cellular and molecular biomarkers which can provide useful clinical information for diagnosis, classification, prognosis and treatment, as well as the development of new therapeutic strategies. Biomarkers can be found and analyzed in different body compartments, of which the peripheral blood and the intra-articular synovial fluid or tissue are most easily accessible. However, previous studies in RA and other IMIDs showed that adaptive immune responses in other tissues such as lymph nodes also play an important role. Investigating other immune compartments of the body such as the lymph nodes could result in new insights. To study the early pathogenesis of inflammatory conditions, in 2008 our department initiated core-needle inguinal lymph node biopsy sampling. Since then more than 100 lymph node biopsy procedures were performed. The procedure is well-tolerated and, other than a small hematoma which does not require therapy in most of the cases, no complications were reported.
In the current study, the effects of belimumab (anti-BAFF) in SLE will be investigated by studying the immune alterations taking place in lymph nodes in comparison to peripheral blood and immune alterations taking place in the end-organ, e.g. the joint (wrist, knee or ankle) by taking synovial biopsies during a needle- or mini-arthroscopy. This procedure has been performed frequently in our department over the last 15 years. In this way immune alterations in the lymph nodes (secondary lymphoid organ), peripheral blood (systemic) and the joint (end organ for the disease) will be assessed and compared. conditions: Systemic Lupus Erythematosus studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 15 type: ESTIMATED name: Belimumab measure: Differences in lymph node cellular composition as assessed by advanced flow cytometry measure: Differences in peripheral blood cellular composition as assessed by advanced flow cytometry measure: Differences in synovial tissue cellular composition as assessed by advanced flow cytometry sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Amsterdam UMC; location Academic Medical Center status: RECRUITING city: Amsterdam zip: 1100DD country: Netherlands name: Sander W Tas, Prof. dr. role: CONTACT phone: +31 20 56 67765 email: secr-reumatologie@amsterdamumc.nl lat: 52.37403 lon: 4.88969 hasResults: False
nctId: NCT06327711 id: BL77 briefTitle: Benefits of Nutritional Ingredients for Type 2 Diabetes overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-03 date: 2025-03 date: 2024-03-25 date: 2024-03-25 name: Abbott Nutrition class: INDUSTRY briefSummary: This is a prospective randomized, double-blinded, parallel design study to evaluate the benefits of long-term consumption of two experimental blends of liquid supplements. conditions: Diabetes type2 studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 2 groups, non-crossover primaryPurpose: OTHER masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 114 type: ESTIMATED name: Control: CHO Blend name: Experimental: CHO Blend plus AN100 measure: Matsuda Index measure: Fasted Glucose measure: Fasted Insulin measure: Body Weight measure: Body Composition Measurements measure: Continuous Glucose Monitoring measure: Glycated Hemoglobin measure: Resting Energy Expenditure (REE) measure: Microbiome - Fecal measure: Microbiome - Saliva measure: Waist Circumference measure: Hip Circumference measure: Conicity Index measure: Blood Pressure measure: Accelerometry Data measure: Diabetes Distress Scale measure: Dietary Intake measure: Blood biomarkers - inflammation measure: Urine biomarkers - inflammation sex: ALL minimumAge: 40 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06327698 id: AK104-IIT-C-S-0010 briefTitle: Cadonilimab in Combination With Anlotinib in the Treatment of Locally Progressive or Metastatic Melanoma With First-Line Therapy Failure overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2026-05-31 date: 2027-05-31 date: 2024-03-25 date: 2024-03-25 name: Hunan Cancer Hospital class: OTHER briefSummary: This study is an open-label, multicenter, single-arm Phase II clinical study to evaluate the effectiveness of cadonilimab (AK104) in combination with anlotinib in the treatment of locally advanced or metastatic melanoma. conditions: Melanoma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Cadonilimab name: anlotinib measure: Response Rate measure: Progression-free Survival (PFS) measure: Disease Control Rate (DCR) measure: Safety and tolerability sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06327659 id: Thrombectomy by 50 ml syringe briefTitle: Efficacy of Using 50 ml Syringe Manual Thrombectomy Catheter in Primary PCI With Heavy Thrombus Burden overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-01-01 date: 2025-01-01 date: 2024-03-25 date: 2024-03-26 name: Helwan University class: OTHER briefSummary: In high thrombus burden subgroup of Acute STEMI, manual aspiration thrombectomy was associated with reduced cardiovascular death but increased stroke or transient ischemic attack. The role of aspiration thrombectomy is still a matter of active debate. Manual aspiration suffers from decreasing aspiration force as the syringe fills with fluid and requires the operator to exchange syringes during the procedure to maintain suction. conditions: STEMI - ST Elevation Myocardial Infarction conditions: Thrombosis Cardiac studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 88 type: ESTIMATED name: 30 mL syringe manual thrombectomy catheter name: 50 mL syringe manual thrombectomy catheter measure: TIMI flow grade after PCI measure: MBG after PCI measure: Composite rate of occurrence of MACE measure: Rate of cardiovascular death measure: Rate of recurrent myocardial infarction measure: Rate of stroke measure: Rate of cardiogenic shock measure: Rate of NYHA IV heart failure sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Badr University Hospital city: Badr state: Cairo country: Egypt name: Arafa Gomaa, MD role: CONTACT name: Arafa Gomaa, MD role: PRINCIPAL_INVESTIGATOR hasResults: False
nctId: NCT06327646 id: 66677 briefTitle: Maternal Adherence to MMS in Nepal acronym: NAMASTE MMS overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2024-07-20 date: 2024-07-20 date: 2024-03-25 date: 2024-03-25 name: Helen Keller International class: OTHER name: Eleanor Crook Foundation briefSummary: Although clinical studies highlight the value of MMS for pregnant and lactating women, implementation research studies are necessary to understand adherence and acceptability to the product and to uncover potential obstacles to implementation in specific contexts. For Nepal, it is crucial to establish whether adherence to MMS supplementation is non-inferior to the existing IFA supplementation for 180 tablets, which has a high (65%) adherence rate. It is also important to investigate how whether providing MMS in bottles (containing a substantial quantity, such as 90 count bottles twice during pregnancy) might impact ANC utilization, particularly in terms of ensuring that pregnant women attend at least eight ANC visits. Furthermore, assessment of MMS acceptability, including pill taste, smell, size, swallowability, side effects, benefits as well as aspects such as product labeling and packaging, among end users in Nepal, is needed to understand acceptability of MMS vs. IFA. Finally, implementation issues within the health system, including the need of trainings for healthcare workers' and, female community health volunteers (FCHVs)' training needs; and government stakeholders' interest and barriers;; community s Social and behavioral change communication needs, and issues around supply chain issues should be well-understood and documented to inform prior to scale-up to support a smooth transition of MMS. Thus, Helen Keller International, in collaboration with Nepal's Ministry of Health and Population (MoHP) and the Eleanor Crook Foundation (ECF), will conduct a set of four mixed-methods studies to generate evidence and insights that inform the development of an MMS supplementation strategy. This trial in one province of Nepal is the first study that will be complemented by one additional quantitative study and two qualitative studies to generate evidence on the topics mentioned. conditions: Supplementation conditions: Pregnancy Related conditions: Postnatal Related studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 2640 type: ESTIMATED name: Multiple Micronutrient Supplement Blister name: Multiple Micronutrient Supplement Bottle name: Iron Folic Acid Blister measure: 180 days adherence: MMS (2 types) vs. IFA measure: 30, 90, and 225 days adherence measure: 180 adherence: MMS blister vs MMS bottle measure: MMS acceptability measure: Antenatal Care Utilization at 180 days sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT hasResults: False
nctId: NCT06327633 id: ZZ2024 briefTitle: Effects of Olfactory Training on the Brain Function in T2DM Patients With Mild Cognitive Impairment overallStatus: RECRUITING date: 2024-01-01 date: 2024-08-01 date: 2024-08-01 date: 2024-03-25 date: 2024-03-26 name: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School class: OTHER briefSummary: This is a pilot, prospective, randomized, open label, parallel, 4-month study to explore and evaluate the therapeutic effects of olfactory training on the cognitive function, olfactory function, and odor-induced brain activation in T2DM patients with mild cognitive impairment (MCI). conditions: Type 2 Diabetes Mellitus conditions: Mild Cognitive Impairment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: Olfactory Training measure: Change of olfactory brain activation by fMRI measure: Change of cognitive function measure: Olfactory threshold test measure: Change of metabolism sex: ALL minimumAge: 40 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Division of Endocrinology, the Affiliated Drum Tower Hospital of Nanjing University status: RECRUITING city: Nanjing state: Jiangsu zip: 210008 country: China name: Yan Bi, MD, PhD role: CONTACT phone: 86-25-83-105302 email: biyan@nju.edu.cn name: YAN BI, MD, PhD role: PRINCIPAL_INVESTIGATOR name: ZHOU ZHANG, MD, PhD role: SUB_INVESTIGATOR lat: 32.06167 lon: 118.77778 hasResults: False
nctId: NCT06327620 id: A002021015 briefTitle: Treatment Of Oral Lichen Planus overallStatus: RECRUITING date: 2022-01-15 date: 2024-05-20 date: 2024-05-20 date: 2024-03-25 date: 2024-03-25 name: Mansoura University class: OTHER briefSummary: This novel project aims to explore an alternative treatment for oral lichen planus (OLP), a challenging condition with limited therapeutic options. The proposed treatment involves the topical application of Daivobet ointment, a combination of calcipotriol (vitamin D analog) and betamethasone (corticosteroid), which has shown promising results in the treatment of psoriasis Vulgaris.
The project aims to provide valuable insights into the efficacy and safety of the Daivobet ointment as a potential alternative treatment for oral lichen planus, offering hope for improved outcomes for patients suffering from this challenging condition. conditions: Lichen Planus studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 15 type: ESTIMATED name: Daivobet ointment, topical steroids measure: Clinical Improvement of Oral Lichen Planus Lesions measure: Objective Response Score measure: Subjective Response Score sex: ALL minimumAge: 30 Years maximumAge: 60 Years stdAges: ADULT facility: Mansoura University, Faculty of Dentistry status: RECRUITING city: Mansoura state: Dakahlia zip: 35516 country: Egypt name: Mona Montaser role: CONTACT email: mmontaser@mans.edu.eg lat: 31.03637 lon: 31.38069 hasResults: False
nctId: NCT06327607 id: IEO 1952 briefTitle: Psychosexuological Interventions to Support Sexual Function in Breast Cancer Patients overallStatus: RECRUITING date: 2023-06-09 date: 2024-12-31 date: 2024-12-31 date: 2024-03-25 date: 2024-03-25 name: European Institute of Oncology class: OTHER briefSummary: Prospective pilot study on the feasibility and efficacy of a brief psychosexual support intervention in breast cancer patients undergoing hormonal therapies for at least 6 months.
Control arm (standard care pathway) Psychosexual intervention arm conditions: Breast Cancer studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 82 type: ESTIMATED name: Control Group name: Psychosexological intervention measure: Evaluation of differences between two arms in female sexual satisfaction and functionality scores measure: Evaluation of differences between two arms in levels of quality of life measure: Evaluation of differences between two arms in levels of anxiety and depression measure: Evaluation of differences between two arms in levels of sleep quality sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: European Institute of Oncology status: RECRUITING city: Milan country: Italy name: Gabriella Pravettoni role: CONTACT lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06327594 id: XTang-0002 briefTitle: Assessment System of Sarcopenia in Lung Cancer Patients overallStatus: RECRUITING date: 2023-11-01 date: 2027-11 date: 2028-11 date: 2024-03-25 date: 2024-03-25 name: West China Hospital class: OTHER briefSummary: 1. To explore the diagnostic value of musculoskeletal cross-modal imaging assessment system of ultrasound combined with abdominal CT/MRI for sarcopenia in patients with lung cancer.
3. To explore the value of musculoskeletal cross-modal imaging assessment system of ultrasound combined with abdominal CT/MRI in evaluating the long-term prognosis of patients with lung cancer. conditions: Sarcopenia conditions: Lung Cancer conditions: Ultrasound studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 1500 type: ESTIMATED name: ultrasound scan name: CT/MRI scan measure: Death measure: Perioperative complications sex: ALL minimumAge: 40 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Xinyi Tang status: RECRUITING city: Chengdu state: Sichuan country: China name: Xinyi Tang, Dr. role: CONTACT phone: +8615680819215 lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06327581 id: 101005 briefTitle: Combined Microneedling With Either 1% Lactic Acid Solution or Vitamin D3 or Triamcinolone Acetonide in The Treatment of Alopecia Areata overallStatus: RECRUITING date: 2023-12-15 date: 2024-09-23 date: 2024-12-22 date: 2024-03-25 date: 2024-03-25 name: Zagazig University class: OTHER_GOV briefSummary: Alopecia areata (AA) is an immunologically mediated disease characterized by non-scarring hair loss (Madni and Shapiro, 2000). AA is presented by rapid and complete hair loss in one or more round or oval patches, usually on the scalp, beard area, eyebrows, eyelashes, and less commonly, on other hairy areas of the body (Berker et al., 2010 and James et al., 2011) Alopecia areata is a T-cell-mediated autoimmune disease. There is a complicated interplay between loss of immune privilege in the hair follicle, autoimmune-mediated hair follicle damage, and activation of inflammatory pathways that have been argued to explain the development of this disorder, but the exact pathophysiology of AA remains unknown. Hair follicles are infiltrated by autoreactive CD8 and CD4 T lymphocytes, which attack hair follicle-derived autoantigens while sparing the stem compartment (Rajabi et al., 2018).
Alopecia areata can be treated with topical and/or intralesional corticosteroids, which are the treatment of choice. Anthralin, minoxidil, coal tar, and topical immunotherapy are examples of other topical treatments. Systemic immunosuppressants such as cyclosporine, systemic steroids, Janus kinase inhibitors, and methotrexate may be considered in severe resistant cases (lee and lee, 2017).
Lactic acid is a member of alpha-hydroxy acids. It has been used in the treatment of many skin diseases, like AA and vitiligo. Lactic acid stimulates spontaneous secretion of vascular endothelial growth factor (VEGF) by human reconstructed epidermis. VEGF is an angiogenic cytokine involved in angiogenesis and wound healing and stimulates the growth of hair follicles resulting in recovery of AA. Other studies suggest that lactic acid may act through its irritant effect (Al-Tammimy, 2005).
All cells of the immune system express 1,25-dihydroxyvitamin D3 receptors (VDRs) and are therefore vulnerable to calcitriol-mediated modulation. Vitamin D3 has the ability to influence the migration and maturation of different dendritic cell subtypes and their production of chemokines and cytokines, giving them an immunoregulatory and tolerogenic role (Illescas-Montes et al., 2019) It has been shown that VDRs are highly expressed in the keratinocytes of human hair follicles and the absence of their expression is associated with reduced hair follicle growth and epidermal differentiation. Reduced VDR expression in the hair follicles of affected areas has also been observed in studies of AA patients' scalp (Çerman et al., 2015).
Microneedling (MN) is a technique that comprises puncturing the skin repeatedly with sterile microneedles (Iriarte et al., 2017). It promotes hair regeneration by triggering stem cells in the hair bulge, which results in the generation of growth factors. It also improves blood circulation to the hair follicles and influences the local immune cells (Chandrashekar et al., 2014). Moreover, combining MN with applied topical drugs facilitates their absorption through the microchannels created within the epidermis (Fertig et al., 2018). conditions: Alopecia Areata studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 44 type: ESTIMATED name: Lactic Acid name: vit D name: Triamcinolone Acetonide name: Saline measure: hair regrowth improvement assessed by 5-point semiquantitative regrowth score (RGS) sex: ALL minimumAge: 16 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Rana Ehab status: RECRUITING city: Zagazig zip: 44519 country: Egypt name: rana ehab, md role: CONTACT phone: 01000896453 email: ranaehab015@gmail.com lat: 30.58768 lon: 31.502 hasResults: False
nctId: NCT06327568 id: IEO 1663 briefTitle: Anal Cancer and/or Precancer Screening: Performance Analysis of the BD Onclarity™ HPV Assay on Anal Specimens overallStatus: RECRUITING date: 2022-06-17 date: 2026-06-17 date: 2029-06-17 date: 2024-03-25 date: 2024-03-26 name: European Institute of Oncology class: OTHER briefSummary: Human papillomavirus (HPV) infection has been implicated as a necessary cause for the development of the majority of anogenital neoplasms which represent approximately 95% of anal tumors. Persistent high risk HR-HPV infection promotes progression from intraepithelial lesions high-grade squamous anal tumors (AIN) (H-SIL) to invasive anal tumors.
The performance analysis of an HPV Test with simultaneous genotyping on anal samples could implement anal cancer screening without an invasive procedure and with one simple approach. conditions: Anal Intraepithelial Neoplasia 2 conditions: Anal Intraepithelial Neoplasia 1 conditions: Anal Cancer conditions: High-Risk Cancer studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: Sensitivity and specificity of BD Onclarity HPV assay for HPV detection and genotyping in case/control patients. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: European Institute of Oncology status: RECRUITING city: Milan country: Italy name: Fabio Bottari role: CONTACT name: Cristina Trovato, MD role: SUB_INVESTIGATOR name: Anna Daniela Iacobone, MD role: SUB_INVESTIGATOR lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06327555 id: M2023123 briefTitle: Study on the Effect of Telerehabilitation Using Wearable Devices After ACL Reconstruction overallStatus: RECRUITING date: 2023-09-01 date: 2024-12-31 date: 2025-06-30 date: 2024-03-25 date: 2024-03-25 name: Peking University Third Hospital class: OTHER briefSummary: Trial purpose: To evaluate the safety and effectiveness of using a new remote rehabilitation platform for postoperative rehabilitation in patients with anterior cruciate ligament rupture compared to conventional rehabilitation care through a randomized controlled trial.
Trial plan: The subjects were randomly enrolled and randomly divided into two groups: the remote rehabilitation group and the traditional rehabilitation group, using a mixed block randomization method. The probability of being divided into both groups was 50%. All subjects received routine outpatient diagnosis and treatment, with the same content. The remote rehabilitation group uses software and sensors to provide remote postoperative rehabilitation guidance. The traditional rehabilitation group receives routine rehabilitation diagnosis and treatment, with face-to-face rehabilitation twice a week. All subjects are required to undergo regular follow-up (1 day before surgery, 3 months after surgery, 6 months).