hackint0sh/New-Dataset huggingface dataset:
* Phase 2: Open label study (active condition) primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 32 type: ESTIMATED name: EXOPULSE MOLLII SUIT (active) name: EXOPULSE MOLLII SUIT (sham) measure: Improvement in balance using the PBS (Pédiatric Balance Scale) before and after active and sham stimulation measure: Evaluation of the cumulative effects of EXOPULSE Mollii suit on balance using the PBS measure: Evaluation of the effects of EXOPULSE Mollii suit on spasticity using the Modified Ashworth Scale (MAS) measure: Evaluation of the effects of EXOPULSE Mollii suit on mobility using the Timed Up and Go test (TUG) measure: Quality of life will be measured using the EuroQol 5 dimensions quality of life questionnaire for youth (EQ-5D-Y) measure: Pain will be assessed using the Pain Scale Chart (PSC) measure: Evaluation of overall improvement using the Clinical Global Impression (CGI) sex: ALL minimumAge: 5 Years maximumAge: 12 Years stdAges: CHILD facility: Centre Hospitalier Intercommunal D'Aix Pertuis status: RECRUITING city: Aix-en-Provence country: France name: PASCAL GRANIER, MD role: PRINCIPAL_INVESTIGATOR name: HELENE RAUSCENT, MD role: SUB_INVESTIGATOR lat: 43.5283 lon: 5.44973 facility: Centre Medico Chirurgical de Readaptation Des Massues status: NOT_YET_RECRUITING city: Lyon country: France name: EMMANUELLE CHALEAT - VALAYER, MD role: PRINCIPAL_INVESTIGATOR name: Marie-Charlotte D'ANJOU, MD role: SUB_INVESTIGATOR lat: 45.74848 lon: 4.84669 facility: Centre de Sante Rossetti status: RECRUITING city: Nice country: France name: GAUTIER DE CHELLE, MD role: PRINCIPAL_INVESTIGATOR lat: 43.70313 lon: 7.26608 facility: Centre de Readaptation Pediatrique D'Oleron status: RECRUITING city: Saint-Trojan-les-Bains country: France name: SOLENE VIOT, MD role: PRINCIPAL_INVESTIGATOR lat: 45.84134 lon: -1.20728 hasResults: False
nctId: NCT06266273 id: SBA 23/442 briefTitle: Investigating the Development, Validity, and Reliability of the Avoidance of Sports Activities Photo Scale overallStatus: RECRUITING date: 2024-01-01 date: 2024-06-30 date: 2024-08-30 date: 2024-02-20 date: 2024-02-20 name: Hacettepe University class: OTHER briefSummary: "Investigating the Development, Validity, and Reliability of the Avoidance of Sports Activities Photo Scale" is crucial in determining the specific functional status of the shoulder joint, especially for overhead athletes experiencing shoulder pain, to identify which sporting activities restrict them the most and to fill the gap in the literature. Additionally, visually indicating activities through photographs will provide visual feedback, making it easier to assess functional status. Our study aims to develop a specific functional survey for the shoulder joint in overhead athletes, examine the validity and reliability of this scale, and contribute to the literature. conditions: Questionnaire conditions: Athletes conditions: Shoulder Pain studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 170 type: ESTIMATED name: No intervention measure: Investigating the Development, Validity, and Reliability of The Sports Activity Avoidance Photo Scale sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Elif Turgut status: RECRUITING city: Ankara zip: 06300 country: Turkey name: Elif Turgut, Assoc. Prof. role: CONTACT phone: +90 (544) 264 56 00 email: elif.turgut.pt@gmail.com name: Birgül DINGIRDAN, Master role: SUB_INVESTIGATOR name: Büşra PAKÖZ, Master role: SUB_INVESTIGATOR name: Kübra ÇAYLAN GÜRSES, Master role: SUB_INVESTIGATOR name: Pınar KUYULU HAKSAL, Master role: SUB_INVESTIGATOR lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06266260 id: 5486 briefTitle: Evaluation of the Performance of Direct Portal Pressure Measurement by Endoscopic Ultrasound in a Large Cohort of Patients With Advanced Chronic Liver Disease of Different Etiologies and Newly Diagnosed Clinically Significant Portal Hypertension (EVADIPP) acronym: EVADIPP overallStatus: RECRUITING date: 2023-09-11 date: 2025-04-01 date: 2026-04-01 date: 2024-02-20 date: 2024-02-20 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: A minimally invasive procedure to directly assess portal pressure gradient under endoscopic ultrasound guidance (EUS-PPG) has become available and initial data have proved the technique to be safe. Aims of our proposal are: (i) to assess performance of EUS-PPG as compared to HVPG in evaluating hemodynamic response to non selective betablockers (NSBBs) in a large cohort of patients with CSPH;(ii) identification of markers of hemodynamic response(iii) identification of factors potentially affecting the accuracy of PPG measurement. conditions: Portal Hypertension studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: EUS PPG measurement measure: Measurement of the portal pressure gradient though endoscopic ultrasound (EUS) and hepatic venous pressure gradient (HVPG) to evaluate the hemodynamic response to non-selective beta blockers (NSBBs) measure: Measurement of the portal pressure gradient though endoscopic ultrasound (EUS) and hepatic venous pressure gradient (HVPG) to evaluate the hemodynamic response to non-selective beta blockers (NSBBs) measure: Markers of hemodynamic response measure: Markers of hemodynamic response measure: Markers of hemodynamic response sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Policlinico Gemelli IRCCS status: RECRUITING city: Roma zip: 00168 country: Italy name: Francesco Santopaolo, MD role: CONTACT phone: +393492754288 email: francesco.santopaolo@policlinicogemelli.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06266247 id: 06-2023/16 id: KMU-BAP type: OTHER domain: KMU briefTitle: How Sirtuin Levels Change During Behçet Disease overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-15 date: 2024-06-30 date: 2024-10-30 date: 2024-02-20 date: 2024-02-20 name: Karamanoğlu Mehmetbey University class: OTHER briefSummary: Our primary aim in our study is to evaluate the relationship between the activity, which will be evaluated by clinical and standard phase reactants, and the IL-6 and TNF-α levels, which will be measured in serum, in Behçet\'s patients. Our secondary aim was to evaluate Sirtuin-1 in Behcet\'s patients and compare it with the normal population. Our third aim is to find out whether there is a relationship between these values and organ involvement. conditions: Behçet Disease conditions: Inflammation conditions: Vasculitis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 60 type: ESTIMATED name: Take blood samples measure: Our primary aim is to evaluate the relationship between the activity to be evaluated with clinical and standard acute phase reactants and the IL-6 and TNF-α levels to be measured in serum in Behçet's patients. sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Karamanoğlu Mehmetbey University city: Karaman country: Turkey lat: 37.18111 lon: 33.215 hasResults: False
nctId: NCT06266234 id: APHP230600 id: 10723253 Bis type: OTHER domain: CESREES briefTitle: Characterization by Automated System on Infantile Spasmes acronym: REASSESS overallStatus: RECRUITING date: 2024-02-01 date: 2026-01 date: 2026-01 date: 2024-02-20 date: 2024-03-13 name: Assistance Publique - Hôpitaux de Paris class: OTHER name: OSO-AI briefSummary: Infantile spasms are defined by the occurrence of epileptic episodes characterized by the appearance of very specific motor seizures, made up of rapid, repeated contractions in flexion or extension known as spasms. This syndrome is of high concern as it will lead to mental retardation if it is not early identified and treated. Most often, spasms are characterized by sudden contractions of the body in flexion. More rarely, spasms occur in extension: the neck and legs suddenly tense, and the arms move upwards or sideways. Spasms may be accompanied by eye revulsion. They are brief, lasting 0.5 to 2 seconds each. At the start of the attack, they may be isolated, but then may occur in series lasting up to several tens of minutes.
The gold standard for diagnosing infantile spasms is to capture them on video-EEG to conﬁrm the ictal correlate of the seizure. Although multiple variations are known, the ictal correlation is often a diffuse slow wave of high amplitude with subsequent electrodecrement. Yet continuous video electroencephalogram is an expensive and time-consuming resource often unavailable in developing countries and in many parts of the developed world. Furthermore, in an appropriate clinical scenario, continuous video-EEG may be unnecessary. For example, a home video examination with typical spasms combined with a deﬁnitively epileptic ambulatory EEG may certainly be adequate for the diagnosis of infantile spasms
As part of Mr. Diop's thesis, the study team have developed a system for analyzing videos acquired in 2 dimensions from a simple smartphone or webcam and highlighting the existence of spasms in a child. The principle is to use computer vision and computer learning model to identify the spasms from these videos. The first prototype of this system achieved a positive predictive value of 77%, which is very good considering the small sample used (\< 100) but quite insufficient to obtain a diagnostic prediction for medical use, for which we hope for sensitivity and specificity of around 95%.
To achieve this goal, we need access to a standardized reference database that currently exists in the various pediatric electrophysiology laboratories of the Assistance Publique - Hôpitaux de Paris and the Île-de-France region. we propose using the films stored in these laboratories to teach the computer to recognize spasms that have already been formally identified by electrophysiologists and by ictal concordance. conditions: Infantile Spasm studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 5000 type: ESTIMATED measure: Automated computer detection of the spasms > 95% measure: Automated computer detection of the non spasms > 95% sex: ALL maximumAge: 3 Years stdAges: CHILD facility: Department of paediatric neurological care and intensive care unity (PICU), Raymond Poincaré hospital - APHP status: RECRUITING city: Garches zip: 92380 country: France lat: 48.84226 lon: 2.18232 hasResults: False
nctId: NCT06266221 id: APHP200073 id: 2022-000712-59 type: EUDRACT_NUMBER briefTitle: Severe Erythema Multiforme - CORTICO acronym: SEMCORTICO overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-06-01 date: 2027-11-01 date: 2024-02-20 date: 2024-02-20 name: Assistance Publique - Hôpitaux de Paris class: OTHER briefSummary: Erythema multiforme (EM) is an acute and often recurrent mucocutaneous disease. EM is considered a hypersensitivity immune-mediated reaction. The two main known triggering factors are Herpes simplex virus (HSV) and Mycoplasma pneumoniae (MP) infections. Typical target skin lesions characterize EM, especially oral MMs. EM is in fact mainly linked to the oral MM involvement, including intense mucosal pain, impaired food intake, weight loss, hospitalization and potential risk of fibrotic sequelae (oral, ocular, genital, oesophageal, respiratory tract) and recurrences.
The objectives of treatment for severe EM in the acute phase are to reduce the duration of lesions, prevent complications and mucosal sequelae. However, despite the lack of evidence and consensus some medical teams often use a short regimen of SCS hoping to obtain a quicker improvement of the condition. However, the use of SCS at the acute phase is not codified and remains debated according to the existent literature. Current studies are mostly retrospective and based on small cohorts or case reports. A randomized, controlled trial would be therefore essential to properly evaluate the benefit of SCS in this pathology and provide strong support to clinicians in their decision making in severe EM during the acute phase.
This research will be a Phase III randomized, multicentric, double-blind, controlled trial with two parallel groups. The efficacy of prednisone, oral at 1 mg/kg/day for 3 days, tapered to 0.75 mg/kg/day for 3 days, 0.50 mg/kg/day for 3 days, 0.25 mg/kg/day for 3 days is compared to that of placebo, oral for 12 days or IV methylprednisolone if oral route is impossible because of the self-reported inability for the patient to swallow due to the impacts of the oral lesions, with dosage equivalence at 0.8 mg/kg/day for 3 days, tapered to 0.6 mg/kg/day for 3 days, 0.4 mg/kg/day for 3 days, 0.2 mg/kg/day for 3 days, then stopped, compared to that of placebo.
An interim analysis is planned after the inclusion of 50 patients. Results of the interim analysis will be presented to the DSMB. During the interim analysis, inclusions may continue. conditions: Erythema Multiforme studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 96 type: ESTIMATED name: Prednisone 20 Mg name: Oral Placebo name: Methylprednisolone 120 Mg name: IV Placebo measure: Time to success measure: Evaluation of Pain measure: Food intake measure: Rescue therapy intake measure: Time to clear or almost clear healing of all sites measure: Time to fever resolution measure: Length of hospital stay measure: Number of days of consumption of level III analgesics measure: Evaluation of pain measure: Chopped or solid food intake resumption measure: Rate of patients in the two groups with need for a rescue therapy measure: Rate of sequelae measure: Rate of adverse events during the treatment and follow-up measure: Evaluation of the quality of life sex: ALL minimumAge: 15 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06266208 id: UCV/2021-2022/201 briefTitle: Utility of High-resolution Ultrasound to Evaluate Dorsal Osteophyte overallStatus: RECRUITING date: 2024-03-20 date: 2024-04-15 date: 2024-07-15 date: 2024-02-20 date: 2024-04-23 name: Fundación Universidad Católica de Valencia San Vicente Mártir class: OTHER briefSummary: This study will evaluate the usefulness of ultrasonography in detecting dorsal osteophytes associated with claw nails compared to radiographs. The hypothesis will be that the larger the size of the osteophyte, the greater the nail curvature.
Ultrasonography could constitute a safe and effective alternative to radiology for detecting dorsal osteophytes in claw nails, especially in mild cases, follow-ups or young patients. conditions: Exostosis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 150 type: ESTIMATED name: Exostectomy name: Cut fingernail measure: Nail-phalange distance measure: Nail Curvature Index measure: Thickness of the nail plate measure: Dorsal Osteophyte Height sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Enieto podologos status: RECRUITING city: Logroño state: La Rioja zip: 26003 country: Spain name: Eduardo Nieto-Garcia, Dr role: CONTACT phone: 941 25 55 66 email: clinica@enietopodologos.com name: eduardo Nieto-Garcia, Dr role: CONTACT phone: 941 25 55 66 email: eduardo.nieto@ucv.es name: Eduardo Nieto-Garcia, Dr role: SUB_INVESTIGATOR lat: 42.46667 lon: -2.45 facility: Centro podológico Valencia status: RECRUITING city: Valencia state: València zip: 46001 country: Spain name: Martín Redón role: CONTACT phone: 96 352 63 41 email: info@podologomartinredon.com name: Emma Guillem-escámez role: CONTACT phone: 96 352 63 41 email: em_chec@mail.ucv.es name: emma Guillem-Escamez role: PRINCIPAL_INVESTIGATOR lat: 39.46975 lon: -0.37739 facility: Clinicas UCV status: RECRUITING city: Valencia state: València zip: 46001 country: Spain name: Pablo Vera-Ivars, Dr. role: CONTACT phone: 963 92 06 24 email: clinicas.ucv@ucv.es name: Cristina Mico-Salcedo role: CONTACT phone: 963 92 06 24 email: clinicas.ucv@ucv.es name: Javier Ferrer-Torregrosa, Dr role: PRINCIPAL_INVESTIGATOR name: Juan Vicente-Mampel, Dr. role: PRINCIPAL_INVESTIGATOR lat: 39.46975 lon: -0.37739 facility: Clinica Pasito a pasito status: RECRUITING city: Valencia zip: 46008 country: Spain name: Javier Ferrer-Torregrosa, Dr role: CONTACT phone: 963855535 email: clinicaspasitoapasito@gmail.com name: Javier Ferrer-Torregrosa, Dr role: CONTACT phone: 644733882 email: javier.ferrer@ucv.es name: JAVIER Ferrer- TORREGROSA, Dr role: PRINCIPAL_INVESTIGATOR lat: 39.46975 lon: -0.37739 hasResults: False
nctId: NCT06266195 id: 5452 briefTitle: Spectroscopic Profiling of Extracellular Vesicles By Resonant Gold Nanostructures in the Infrared acronym: PROVEIR_1 overallStatus: RECRUITING date: 2023-03-15 date: 2023-12-31 date: 2025-02-28 date: 2024-02-20 date: 2024-02-20 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: Extracellular vesicles, due to their ease of extraction and ability to represent the cells from which they originate, have high potential in the field of personalized medicine, especially in the identification of new early bio-markers of cancer, including hepatocellular carcinoma. Nevertheless, the development of high-throughput diagnostic methods in this area is still in its infancy, and the design of new integrated technological solutions is of great interest and topicality. The main hypothesis of this study is that the development of a novel technology integrating resonant gold nanostructures in the mid-infrared can significantly contribute to the development of new approaches for the diagnosis of hepatocellular carcinoma. conditions: Vesicle studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 64 type: ESTIMATED name: sierological test measure: primary endpoint sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: FPGemelliIRCCS status: RECRUITING city: Roma state: Lazio zip: 00168 country: Italy name: Fabrizio Pizzolante, MD PhD role: CONTACT phone: +390630151 email: fabrizio.pizzolante@policlinicogemelli.it name: Gabriele Ciasca, Professor role: CONTACT phone: +390630151 email: gabriele.ciasca@unicatt.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06266169 id: fpc-2023-ivf-01 briefTitle: Application of Spectral Methods to Assess Gametes, Embryos, and Human Reproductive Capabilities overallStatus: RECRUITING date: 2023-09-20 date: 2024-02-28 date: 2025-12-31 date: 2024-02-20 date: 2024-02-20 name: Family Planning Center of Women's Welfare Clinic #44 of Pushkin District class: OTHER_GOV briefSummary: Relevance of the research topic: At present, in the world, a kind of "plateau" in the efficiency of assisted reproductive technologies has been achieved, which ensures a birth rate of 30% per embryo transfer. At the same time, a relatively high (15-20%) and stable rate of miscarriages is preserved. Until now, no effective methods for assessing the potential of gametes and embryos, as well as human reproductive capabilities, have been offered. In these conditions, to increase the rate of births after IVF, clinicians have to increase the number of transferred embryos at a time, however, this leads to a sharp increase in complications of IVF, such as multiple pregnancy. In addition, until today, the clinical effectiveness of assessing the potential of endometrium using gene expression determination methods has not been shown. Therefore, to ensure the effectiveness and safety of infertility treatment, it is necessary to develop methods for predicting the potential of gametes and embryos, as well as human reproductive capabilities. For this purpose, the investigators assume to use Raman spectroscopy of the environment obtained from the objects of research, as well as fluorescent spectroscopy of endometrium. The objects of the research are gametes (spermatozoa) and embryos, used culture medium, endometrium. The subject of the study is the set of factors, that exists in the objects of research and their ability to determine the outcomes of infertility treatment. conditions: Infertility studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: For the retrospective (observational) stage of the study:
For each object of study, the size of the dataset for prospective testing can only be determined after passing the observational part of the study. primaryPurpose: OTHER masking: SINGLE whoMasked: PARTICIPANT count: 1064 type: ESTIMATED name: making artificial intelligence based decisions of gamete, embryo and endometrial potential measure: Embryonic model performance measure: Gamete model performance measure: Endometrial model performance measure: Embryonic model clinical efficiency measure: Endometrial model clinical efficiency sex: ALL minimumAge: 20 Years maximumAge: 44 Years stdAges: ADULT facility: Family planning center status: RECRUITING city: Saint Petersburg state: Pushkin zip: 196608 country: Russian Federation name: Alexey Gryaznov role: CONTACT phone: +7(812)414-57-09 email: libra19831010@mail.ru lat: 59.93863 lon: 30.31413 hasResults: False
nctId: NCT06266156 id: BMU-HTUNC-01 briefTitle: Evaluation of The Effect of Consecutive Dental Visits on Dental Anxiety of Paediatric Patients overallStatus: COMPLETED date: 2023-08-05 date: 2023-11-03 date: 2023-12-27 date: 2024-02-20 date: 2024-02-20 name: Burdur Mehmet Akif Ersoy University class: OTHER briefSummary: The goal of this observational study is to learn about in effect of consecutive dental visits on dental anxiety of paediatric patients.
Researchers will compare paeditric patients have two caries on mandibular molars to see if changes dental anxiety levels and physiological parameters such as heart rates and oxygen saturations during dental treatments in consecutive dental treatment sessions. conditions: Dental Anxiety studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 240 type: ACTUAL name: Score of anxiety questionnaire name: Heart rate name: Oxygen saturation measure: Determination of sample size. measure: Inviting participants to the study. measure: Determination of dental anxiety score of participants before dental treatment in first dental session measure: Heart rate measuring in first dental session. measure: Oxygen saturation measuring in first dental session. measure: Determination of dental anxiety score of participants after dental treatment in first dental session measure: Determination of dental anxiety score of participants before dental treatment in second dental session measure: Heart rate measuring in second dental session. measure: Oxygen saturation measuring in second dental session. measure: Determination of dental anxiety score of participants after dental treatment in second dental session sex: ALL minimumAge: 6 Years maximumAge: 9 Years stdAges: CHILD facility: Burdur Mehmet Akif Ersoy University Faculty of Dentistry city: Burdur state: Centrum zip: 15100 country: Turkey lat: 37.72028 lon: 30.29083 hasResults: False