nctId: NCT06300320 id: TQ05105-II-06 briefTitle: A Clinical Trial of TQ05105 Tablets in the Treatment of Chronic Graft-versus-host Disease overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-10 date: 2026-04 date: 2024-03-08 date: 2024-03-08 name: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. class: INDUSTRY briefSummary: This is an open, multi-center clinical study designed to evaluate the efficacy and safety of TQ05105 Tablets in patients with chronic graft-versus-host disease conditions: Chronic Graft Versus Host Disease studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: TQ05105 tablets measure: Objective response rate (ORR) at 24 weeks measure: Best objective response rate (BOR) measure: Duration of response (DOR) measure: Failure-free survival (FFS) measure: Incidence rate of malignancy relapse or recurrence measure: Non relapse mortality measure: Overall Survival (OS) measure: Adverse event rate measure: Severity of adverse events (AEs) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Anhui Provincial Hospital city: Hefei state: Anhui zip: 230001 country: China name: Lianxin Liu, PhD role: CONTACT phone: 15255456091 email: xiaoyuz@ustc.edu.cn lat: 31.86389 lon: 117.28083 facility: The 940th hospital of joint logistics support force of Chinese people's liberation army city: Lanzhou state: Gansu zip: 730050 country: China name: Tao Wu, PhD role: CONTACT phone: 13919939297 email: wutaozhen@yeah.net lat: 36.05701 lon: 103.83987 facility: Guangzhou First People's Hospital city: Guangzhou state: Guangdong zip: 510180 country: China name: Shunqing Wang, PhD role: CONTACT phone: 13437801998 email: drwangshq@medmail.com.cn lat: 23.11667 lon: 113.25 facility: The First Affiliated Hospital of Guangxi Medical University city: Nanning state: Guangxi zip: 530021 country: China name: Zhongming Zhang, Master role: CONTACT phone: 15807801369 email: zzmmissyou@126.com lat: 22.81667 lon: 108.31667 facility: The Second Hospital of Hebei Medical University city: Shijiazhuang state: Hebei zip: 050000 country: China name: Xuejun Zhang, PhD role: CONTACT phone: 13722781112 email: zhxjhbmu@126.com lat: 38.04139 lon: 114.47861 facility: Xiangyang Central Hospital city: Xiangyang state: Hubei zip: 441021 country: China name: Guolin Yuan, PhD role: CONTACT phone: 18696231603 email: yuanguo1973@163.com lat: 32.0422 lon: 112.14479 facility: Tai'an Central Hospital city: Taian state: Shangdong country: China name: Guanchen Bai, Bachelor role: CONTACT phone: 18653819776 email: bgcbgc1@163.com lat: 36.18528 lon: 117.12 facility: Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine city: Shanghai state: Shanghai zip: 200025 country: China name: Xiaoxia Hu, PhD role: CONTACT phone: 13795437259 email: hu_xiaoxia@126.com lat: 31.22222 lon: 121.45806 facility: The Second Affiliated Hospital of Xi'an Jiaotong University city: Xian state: Shannxi zip: 710299 country: China name: Aili He, PhD role: CONTACT phone: 13891939962 email: heaili@xiju.edu.cn lat: 34.25833 lon: 108.92861 facility: Hematology Hospital of the Chinese Academy of Medical Sciences city: Tianjin state: Tianjin zip: 300020 country: China name: Er lie Jiang, PhD role: CONTACT phone: 022-23909180 email: jiangerlie@ihcams.ac.cn lat: 39.14222 lon: 117.17667 facility: The First Affiliated Hospital, Zhejiang University School of Medicine city: Hangzhou state: Zhejiang zip: 310000 country: China name: He Huang, PhD role: CONTACT phone: 13605714822 email: hehuangyu@126.com lat: 30.29365 lon: 120.16142 facility: The Affiliated People's Hospital of Ningbo University city: Ningbo state: Zhejiang zip: 315040 country: China name: Ying Lu, Master role: CONTACT phone: 13486090834 email: rmluying@nbu.edu.cn lat: 29.87819 lon: 121.54945 hasResults: False