hackint0sh/New-Dataset huggingface dataset:
Subjects will complete a Numeric Pain Rating Scale (NPR),Oswestry Disability Index (ODI), and a Central Sensitization Inventory before arriving for the study via Qualtrics survey tool. They will be screened for contraindications to manipulation and neurological signs and symptoms. Active forward bending will be quantified by measuring the distance of the subject's fingertips to the floor. Two experienced physical therapists will evaluate the subject's lumbar intervertebral mobility. They will identify the lumbar segment with the least motion or hypomobility. The subjects will be imaged from L1 to S1 with a 5 MHz curvilinear transducer (Edge II MSK ultrasound unit, SonoSite, Inc, Bothell, WA) in the sidlying position with their trunk and hips flexed to end-range. The examiner will save the sagittal image and then place a digital caliper to measure the distance between the spinous processes from the peak of the hyperechoic curvature of the caudal spinous process to the peak of the hyperechoic curvature of the cranial spinous process of each lumbar segment (L5-S1, L4-L5, L3-L2,L2-L1). Subjects will then be randomized to receive a high-velocity low amplitude thrust manipulation or a sham manipulation. The lumbar spine will be reimaged. The ultrasound examiner will be blinded to the manipulation and the caliper measurements. Finally, subjects will be asked for their Global Rating of Change (GROC) and to actively bend forward to remeasure the distance of their fingertips to the floor. One week later, patients will receive an e-mail containing links to repeat the NPR, GROC, and ODI. conditions: Low Back Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants will be randomly assigned to either receive lumbar manipulation or a sham lumbar manipulation. primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Participant: the participants will not know whether they received the lumbar manipulation or sham lumbar manipulation.
Outcome assessor: the outcome assessors will not be involved in collecting data. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: Lumbar Manipulation name: Sham Lumbar Manipulation measure: Diagnostic Ultrasound measure: Trunk Flexion Range Of Motion Measurement measure: Oswestry Disability Questionnaire measure: Numeric Pain Rating Scale measure: Global Rating of Change sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Ithaca College status: RECRUITING city: Ithaca state: New York zip: 14850 country: United States name: John Winslow role: CONTACT phone: 607-229-8792 email: jwinslow@ithaca.edu name: Michael Costello role: CONTACT email: mcostello@ithaca.edu lat: 42.44063 lon: -76.49661 hasResults: False
nctId: NCT06294119 id: MANCAVA id: 2022SLB5MX type: OTHER_GRANT domain: Italian Ministry of Research briefTitle: Multivariate Approach to the Numerical Assessment of Cortical - Autonomic - VAscular Dynamic Interplay overallStatus: RECRUITING date: 2024-02-08 date: 2026-02-08 date: 2026-02-08 date: 2024-03-05 date: 2024-03-05 name: IRCCS Policlinico S. Donato class: OTHER briefSummary: MANCAVA sets out fundamental methodologies for characterizing human fundamental physiological system interactions at a whole-body level, particularly focusing on the interplay among cortical brain activity, autonomic function, and cerebrovascular autoregulatory mechanisms. By investigating the complex, time-varying mechanisms underlying the multisystem dynamic interactions, novel methods linking various brain areas and reflex functions to target organs and districts such as heart and circulatory system are proposed with the clinical aim linked to the emerging topic of depression.
Researchers, professionals, and patients will all benefit from a comprehensive assessment of brain-mind-body interplay, leading to the new extended definition of default mode/mood network, neurovascular-evoked responses to autonomic stimuli, brain-autonomic consequences of emotional responses, and physiological substrates of depressive states. conditions: Cardiac Disease conditions: Depression studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 80 type: ESTIMATED name: Major Cardiac surgery measure: Autoregulation index (ARI) measure: number of patients developing depression measure: Baroreflex sensitivity measure: Cortical activity sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Policlinico San Donato status: RECRUITING city: San Donato Milanese state: Milan zip: 20097 country: Italy name: Vlasta Bari, PhD role: CONTACT phone: +390252774381 email: vlasta.bari@grupposandonato.it name: Pavandeep Singh role: CONTACT email: pavandeep.singh@grupposandonato.it name: Marco Ranucci, MD role: PRINCIPAL_INVESTIGATOR name: Vlasta Bari, PhD role: SUB_INVESTIGATOR name: Alberto Porta, PhD role: SUB_INVESTIGATOR name: Francesca Gelpi, Ms role: SUB_INVESTIGATOR name: Beatrice Cairo, PhD role: SUB_INVESTIGATOR lat: 45.41047 lon: 9.26838 hasResults: False
nctId: NCT06294106 id: 24-212 briefTitle: eTMS for Veterans and First Responders With PTSD overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2026-04 date: 2024-03-05 date: 2024-03-05 name: Virginia Polytechnic Institute and State University class: OTHER name: Wave Neuroscience briefSummary: A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial. conditions: Post Traumatic Stress Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 10 participants will receive eTMS treatment 10 participants will receive sham eTMS treatment primaryPurpose: BASIC_SCIENCE masking: DOUBLE maskingDescription: eTMS coil will have an 'active' and 'sham' side and the application will look identical to the participant. The technician will not know which side of the coil is which and will additionally be blinded. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 20 type: ESTIMATED name: Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS) measure: Adverse Events measure: Report of Symptoms measure: PCL-5 sex: ALL minimumAge: 22 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fralin Biomedical Research Institute city: Roanoke state: Virginia zip: 24016 country: United States name: Jessica Florig, MPH role: CONTACT phone: 540-526-2261 email: jnw@vtc.vt.edu name: Wynn Legon, PhD role: PRINCIPAL_INVESTIGATOR lat: 37.27097 lon: -79.94143 hasResults: False
nctId: NCT06294093 id: 026/24 briefTitle: Differences Between Long Distance Road Runners and Treadmill Runners in Achilles Tendon Structure overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-02-15 date: 2025-02-15 date: 2024-03-05 date: 2024-03-07 name: University of Haifa class: OTHER name: Zinman College of Physical Education and Sports Sciences briefSummary: this study will investigate the structure of the Achilles tendon and functional tests in road runners compared to treadmill runners. conditions: Achilles Tendon Injury studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 50 type: ESTIMATED measure: ultrasound tissue characterized measure: Balance test measure: Proprioception test measure: muscle strength test measure: endurance test gastrocnemius muscle sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT hasResults: False
nctId: NCT06294080 id: DfH2023 briefTitle: Effects of Dance and Tai Chi on Balance and Wellbeing on Healthy Adults overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2024-11 date: 2025-01 date: 2024-03-05 date: 2024-03-05 name: University of Wolverhampton class: OTHER briefSummary: The aim of the proposed randomised controlled study is to compare the effects and efficacy between a dance, a Tai Chi and a waiting list control group intervention over an eight-week period on physical functions and mental benefits among non-clinical adults aged between 18 and 59. The study's primary outcome is mental wellbeing and secondary parameters are physical functional and mood. A tertiary outcome will examine how the physical and mental parameters change during the learning and practice phases conditions: General Population studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Random Controlled Trial: Blind primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: Data collection carried out by RAs blinded to participants' group allocation Statistician blinded to the group and test parameters whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 70 type: ESTIMATED name: Dance name: Tai Chi measure: Well-being measure: Leg strength measure: Balance measure: Mood sex: ALL minimumAge: 18 Years maximumAge: 59 Years stdAges: ADULT facility: University of Wolverhampton city: Walsall state: West Midlands zip: WS1 3BD country: United Kingdom lat: 52.58528 lon: -1.98396 hasResults: False
nctId: NCT06294067 id: 43261 briefTitle: A Dose Response Investigation of Docosahexaenoic Acid (DHA) acronym: DRI-DHA overallStatus: RECRUITING date: 2024-03 date: 2025-04 date: 2025-09 date: 2024-03-05 date: 2024-03-27 name: University of Toronto class: OTHER name: Unity Health Toronto briefSummary: Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (n-3 PUFA), commonly consumed from fish, that regulates many critical functions within the body including the brain, eye, and heart. While the metabolic precursor to DHA, alpha-linolenic acid (ALA) is considered nutritionally essential and has a set Dietary Reference Intake (DRI), DHA has not yet been deemed essential and does not have a set DRI. Currently, research suggests an intake range of dietary DHA to be anywhere from 0 to over 500mg/d. The aim of our study is to further investigate a feedback mechanism or accumulation that occurs with eicosapentaenoic acid (EPA) as a result of increased dietary DHA to provide insight for potential Recommended Dietary Intake (RDI) values.
Objectives: 1: To determine the dose-response for DHA to increase blood EPA levels in a mixed vegetarian and vegan population. 2: Investigate the DHA dose and time at dose that increases EPA using natural abundance delta carbon-13 (δ13C) as a tracer. 3: To measure DHA turnover and loss rates. 4: Provide data for exploratory analyses related to PUFA metabolism and the effect of DHA on disease related biomarkers.
Method: During an 8-week trial, 72 healthy vegan or vegetarian males and females (18-50 years) will be supplemented with 1 of 6 algal-oil based DHA doses: 0, 100, 200, 400, 800 or 1000 mg/d. Blood will be collected at days 0, 3, 7, 14, 28 and 56 and will be analyzed for changes in blood EPA levels as the primary outcome and plasma δ13C EPA signature as the secondary outcome.
nctId: NCT06294054 id: 2021/0393/HP briefTitle: Bladder Cancer and Neoadjuvant Chemotherapy Efficiency Before Cystectomy acronym: SELECT overallStatus: ACTIVE_NOT_RECRUITING date: 2023-04-01 date: 2026-03-31 date: 2026-03-31 date: 2024-03-05 date: 2024-03-06 name: University Hospital, Rouen class: OTHER name: Institut Curie briefSummary: This study will allow the investigators to better assess the efficiency of neoadjuvant chemotherapy before cystectomy by training a predictive model on different patient cohorts with bladder cancer. conditions: Bladder Cancer conditions: Genomic Instability studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 707 type: ESTIMATED name: neoadjuvant chemotherapy with cisplatine measure: Progression-free survival measure: Overall survival sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre de lutte contre le cancer François Baclesse city: Caen country: France lat: 49.18585 lon: -0.35912 facility: Centre de recherche des Cordeliers city: Paris country: France lat: 48.85341 lon: 2.3488 facility: Hôpital Saint-Louis AP-HP city: Paris country: France lat: 48.85341 lon: 2.3488 facility: Institut Curie Centre de Recherche city: Paris country: France lat: 48.85341 lon: 2.3488 facility: Institut Curie city: Paris country: France lat: 48.85341 lon: 2.3488 facility: Institut Gustave Roussy city: Paris country: France lat: 48.85341 lon: 2.3488 facility: Mines ParisTech city: Paris country: France lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06294041 id: UEC23/52 briefTitle: INvestigating the Value of Early Sleep Therapy acronym: INVEST overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-06-01 date: 2025-06-01 date: 2024-03-05 date: 2024-03-05 name: University of Strathclyde class: OTHER name: University of Oxford name: University of Glasgow name: NHS Greater Glasgow and Clyde name: NHS Grampian briefSummary: Twenty percent of breast cancer survivors have insomnia, which is defined as persistent trouble falling and/or staying asleep that results in difficulty functioning during the day. Sleep difficulties often begin at cancer diagnosis, become worse during cancer treatment, and continue into cancer survivorship. Insomnia interferes with daily activities and may cause other mental and physical health problems. It also makes it more difficult to cope with cancer treatment and makes recovery more challenging. For these reasons, it is important to address early signs of sleep problems in cancer patients by offering interventions that may prevent the development of insomnia.
This study will address this knowledge gap by randomly assigning newly diagnosed patients with poor sleep to receive either Sleep Restriction Therapy or a sleep hygiene education (SHE) control intervention. The study will assess sleep and mental health before and after both interventions to determine how feasible and acceptable Sleep Restriction Therapy is to patients and to plan for a future, larger study. Throughout, the investigators will work with patients with lived experience of breast cancer and poor sleep to ensure our study is informed by their expertise. conditions: Acute Insomnia (Disorder) studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE maskingDescription: Due to the nature of the SRT intervention, the research nurse, patients and most of the study team cannot be blinded to treatment allocation. However, the statistician will be blinded to treatment allocation (i.e., SRT or SHE) until after analysis is complete whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Sleep Restriction Therapy (SRT) name: Sleep Hygiene Education (SHE) measure: Recruitment rates measure: Retention rates measure: Intervention fidelity: Therapist adherence measure: Intervention fidelity: Patient engagement measure: Intervention fidelity: Control group contamination measure: Outcome measure completion measure: Intervention acceptability measure: Improvement in insomnia severity measure: Improvement in mental health [depression] measure: Improvement in mental health [anxiety] measure: Improvement in rest-activity rhythms [fatigue]Fatigue (FACT-F) measure: Improvement in rest-activity rhythms measure: Improvement in sleep [estimates of subjective sleep] measure: Measure of health related quality of life sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06294028 id: RC31/21/0338 briefTitle: International Multicenter Project Comparing Radiofrequency Ablation Versus Implantable Defibrillator After Well-tolerated Ventricular Tachycardia in Ischemic Heart Disease With Minimally Impaired Ejection Fraction acronym: VIVA overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2029-12-31 date: 2029-12-31 date: 2024-03-05 date: 2024-03-05 name: University Hospital, Toulouse class: OTHER briefSummary: Evidence for the usefulness of the defibrillator in cases of preserved left ventricular ejection fraction and well-tolerated ventricular tachycardia (without cardiocirculatory arrest or syncope) is lacking, as no previous trials have included such patients. Additionally, sudden death in this particular population is low compared to other subgroups of patients with malignant ventricular arrhythmias.
Finally, a very low rate of sudden death was observed in a multicenter European retrospective study that we conducted, including patients with well-tolerated ventricular tachycardia in structural heart disease with minimally impaired ejection fraction and benefiting from ablation without implantation of defibrillator. conditions: Ischemic Heart Disease conditions: Ventricular Tachycardia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 268 type: ESTIMATED name: Adverse events collection name: Quality of life questionnaire EQ-5D-5L name: Medical-economic evaluation measure: Monitoring for the occurrence of at least one serious event during the 36 months of follow-up sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06294015 id: 2023-5009 briefTitle: Efficacy of 20% Autologous Serum Drops in the Treatment of Corneal Epitheliopathy Associated With Antihypertensive Glaucoma Drops. overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-12 date: 2026-04 date: 2024-03-05 date: 2024-03-05 name: Université de Sherbrooke class: OTHER briefSummary: Introduction: Glaucoma is the second leading cause of blindness globally. Most anti-hypertensive drops contain preservatives harmful to the corneal epithelium, with up to 78% of treated patients reporting dry eye symptoms. Autologous serum eye drops (ASED), contains essential growth factors and nutrients which may promote corneal and conjunctival integrity, offering benefits over traditional treatments. This study investigates the efficacy of 20% ASED over placebo in the treatment of corneal epitheliopathies in patients with glaucoma treated with antihypertensive drops.
The study aims to analyze the effectiveness of autologous serum eye drops in treating corneal epitheliopathies in glaucoma patients, potentially offering a new therapeutic avenue. conditions: Corneal Epitheliopathy conditions: Glaucoma conditions: Corneal Disease conditions: Dry Eye studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 25 type: ESTIMATED name: 20% ASED + AT name: 0.9% NS + AT measure: National Eye Index Scores measure: Schirmer Test measure: Visual Acuity measure: Tear Break Up Time measure: Ocular Surface Disease Index measure: Intraocular Pressure measure: Complication rates sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06293989 id: Emergency department briefTitle: Efficacy and Safety of Intravenous Diazepam Given at 2 Different Doses Compared to Placebo in Acute Peripheral Vertigo acronym: Vertigo overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-30 date: 2026-03-30 date: 2024-03-05 date: 2024-04-02 name: University of Monastir class: OTHER briefSummary: This is prospective, randomised double-blind study that will be conducted in the emergency department of 3 university hospitals (FB Monastir, Sahloul Sousse, and FH Sousse) to compare the efficacy of two doses of diazepam (Valium®) and placebo for the relief of acute periphery vertigo in the ED conditions: Vertigo, Peripheral studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 1000 type: ESTIMATED name: Diazepam 5mg name: Diazepam 10 mg name: Placebo measure: Visual analogue scale (VAS)-3H measure: the Delta-VAS measure: the time required to reach the resolution of the vertigo crisis measure: Patients satisfaction measure: number of patients with adverse effects sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06293976 id: 4506 briefTitle: Susceptibility for Entrainment: Role of Ventilator Settings on the Occurrence of Reverse Triggering and Its Physiological Consequences - the SEVeRe Study acronym: SEVERE overallStatus: RECRUITING date: 2024-03-01 date: 2026-03-01 date: 2026-03-01 date: 2024-03-05 date: 2024-03-05 name: Unity Health Toronto class: OTHER briefSummary: Background: Reverse triggering (RT) is a frequent phenomenon observed in sedated patients under a mechanical ventilation mode called assist-control ventilation. RT is when the ventilator would trigger the patient's respiratory effort instead of the correct order of the patient's respiratory effort triggering the ventilator. Reverse triggering can have negative consequences (loss of protective lung ventilation, and causing double breaths - with the ventilator giving two consecutive breaths and not allowing the patient to exhale) but also offer some protective effects (avoid diaphragm disuse atrophy). The balance of its negative vs positive effects depends on its frequency and magnitude of its associated respiratory effort. Respiratory entrainment is the most often referred mechanism involving a change in patient's rate of breathing effort from that of patient's intrinsic rate to the rate of mechanical insufflation. The specific ventilatory settings associated with or responsible for RT remains unknown.
Methods. 30 adult patients (15 in each group), sedated and under assist-controlled ventilation will be included. Ventilator settings will be modified to modulate the frequency and magnitude of reverse triggering. Initially, with the ventilator on a mode called volume control, which means the ventilator controls the amount of air (tidal volume) and the number of breaths the patients gets every minute (respiratory rate \[RR\]). The tidal volume will be set at the current standard clinical practice setting (6 ml/kg of predicted body weight). The presence of an intrinsic respiratory rate will be assessed with an end-expiratory occlusion maneuver. Next, the number of breaths the ventilator gives per minute (RR) will be changed from 6 breaths less to 6 breaths more, in steps of 2 breaths every minute. The protocol will be repeated again changing the amount of air the patients gets (tidal volume) from 4, 5, 7 and 8 ml/kg. Continuous recordings of airway pressure, flow, esophageal pressure, electrical activity of the diaphragm, main accessory muscles and frontal electroencephalography will be obtained during the protocol and baseline clinical and physiological characteristics and outcomes will be recorded. A validated software will be used to detect RT and measure the intensity and timing of each muscle electrical activity and the magnitude of the inspiratory effort during RT. conditions: Respiration, Artificial conditions: Reverse Triggering studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 30 type: ESTIMATED name: Changes in the ventilator respiratory rate and tidal volume measure: The rate of of reverse triggered breaths occurring after each change in the ventilator respiratory rate and tidal volume. measure: The magnitude of the effort, measured by the drop in the esophageal pressure in cmH2O, associated with the reverse triggered breaths after each change in the ventilator respiratory rate and tidal volume sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Unity Health Toronto - St. Michael's Hospital status: RECRUITING city: Toronto state: Ontario zip: M5B 1T8 country: Canada name: Audery Kim role: CONTACT phone: 416-864-5686 email: audery.kim@unityhealth.to name: Antenor Rodrigues role: SUB_INVESTIGATOR name: Laurent Brochard role: PRINCIPAL_INVESTIGATOR lat: 43.70011 lon: -79.4163 hasResults: False