hackint0sh/New-Dataset huggingface dataset:
Mammalian adipose tissue is primarily divided into energy-storing white fat and energy-consuming brown fat. Physical activity, exposure to cold, and other factors induce the transformation of white fat into energy-consuming brown fat, a process known as adipose tissue browning. The occurrence of adipose tissue browning increases the body's energy expenditure and dissipates it in the form of heat, effectively mitigating the onset of obesity. Therefore, the regulatory mechanism of adipose tissue browning has become an important potential target for obesity treatment.
The main component of asthma medication is the β2 adrenergic receptor agonist, which can act on GPCR receptors on the surface of the tracheal smooth muscle through inhalation, causing bronchial dilation and thereby alleviating asthma symptoms. Preliminary experimental results have shown that pulmonary epithelial cells can secrete protein factors that regulate the browning process of adipose tissue, and the expression of these secretory factors is regulated by the cell surface GPCR receptor signaling pathway. Therefore, our goal is to validate the regulatory effect of the asthma medication salbutamol on adipose tissue browning through inhalation administration in humans, establishing a new function for asthma medication in obesity treatment. conditions: Effect of Asthma Medication Salbutamol on Obesity studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Salbutamol measure: Temperature of Scapular Region sex: ALL minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT hasResults: False
nctId: NCT06319170 id: TV44749-NPC-10205 briefTitle: Open-label Trial Characterizing the PK of 3 SC Olanzapine Extended-release Formulations in Participants With Schizophrenia/Schizoaffective Disorder overallStatus: RECRUITING date: 2024-03-28 date: 2024-12-11 date: 2024-12-11 date: 2024-03-19 date: 2024-04-24 name: Teva Branded Pharmaceutical Products R&D, Inc. class: INDUSTRY briefSummary: The primary objective of the study is to characterize the pharmacokinetics of 3 formulations of olanzapine.
The planned duration of the study for each participant is 19 weeks. conditions: Schizophrenia, Schizoaffective Disorder studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 95 type: ESTIMATED name: Olanzapine Extended Release name: Olanzapine measure: Maximum observed plasma drug concentration (Cmax) measure: Area under the plasma drug concentration-time curve (AUC) measure: AUC extrapolated to infinity (AUC0-∞) measure: Number of participants with at least 1 treatment-emergent adverse event (TEAE) measure: Number of participants with at least 1 serious adverse event (SAE) measure: Cmax of ZYPREXA measure: AUC of ZYPREXA measure: Apparent plasma terminal elimination rate constant (λz) of ZYPREXA sex: ALL minimumAge: 18 Years maximumAge: 64 Years stdAges: ADULT facility: Teva Investigational Site 15727 status: RECRUITING city: Hollywood state: Florida zip: 33024 country: United States lat: 26.0112 lon: -80.14949 facility: Teva Investigational Site 15726 status: RECRUITING city: Marlton state: New Jersey zip: 08053 country: United States lat: 39.89122 lon: -74.92183 hasResults: False
nctId: NCT06319157 id: SYSKY-2023-1263-02 briefTitle: Minimal Access Versus Conventional Latissimus Dorsi Flap Harvest for Breast Reconstruction overallStatus: RECRUITING date: 2024-03 date: 2028-11 date: 2028-11 date: 2024-03-19 date: 2024-03-19 name: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University class: OTHER briefSummary: For patients refusing implants for breast reconstruction after cancer surgery, autologous tissue flap reconstruction using the latissimus dorsi muscle is an alternative. Conventional surgery leaves a long incision on the back, affecting aesthetics and quality of life. Minimal access techniques result in a smaller, more concealable scar. While previous studies suggest its safety and effectiveness, most are retrospective. To further validate patient satisfaction and short-term outcomes, a prospective, randomized controlled trial comparing minimal access with conventional surgery is planned. The primary endpoint is Breast Q-satisfaction with back score at 6 months. Secondary outcomes include other Breast Q subscales, surgical metrics, and complications. The study aims to enroll 94 patients in total, providing evidence for surgical decision-making in breast cancer reconstruction. conditions: Breast Neoplasms studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 94 type: ESTIMATED name: minimal access breast reconstruction with a latissimus dorsi muscle flap name: conventional breast reconstruction with a latissimus dorsi muscle flap measure: Breast Q-satisfaction with back measure: Patient satisfaction measure: Latissimus dorsi acquisition time measure: Intraoperative blood loss measure: Postoperative pain measure: Postoperative complications sex: FEMALE minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sun Yat-sen Memorial Hospital, Sun Yat-sen University status: RECRUITING city: Guangzhou state: Guangdong zip: 510120 country: China name: Shicheng Su, M.D., Ph.D. role: CONTACT phone: +86 13632394954 email: lnl_trial@126.com name: Erwei Song, M.D., Ph.D. role: CONTACT phone: +86 13719237746 email: lnl_trial@126.com lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06319144 id: KYLL20240306-1 briefTitle: Effect of Intravenous 5% Dextrose Infusion During Recovery From Anesthesia on the Quality of Early Postoperative Recovery in Patients Undergoing Painless Gastrointestinal Endoscopy overallStatus: RECRUITING date: 2024-03-14 date: 2024-03-14 date: 2024-05-05 date: 2024-03-19 date: 2024-03-19 name: Weifang Medical University class: OTHER briefSummary: The aim of this study was to determine the effect of intravenous infusion of 5% dextrose injection during the recovery period of anesthesia for painless gastroenteroscopy on the patient's blood glucose level, incidence of hypoglycemia and time of awakening from anesthesia, postoperative vertigo, postoperative nausea and vomiting, and quality of recovery in the early postoperative period. conditions: Insulin Resistance conditions: Postoperative Nausea and Vomiting conditions: Quality of Recovery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: 5% glucose name: 0.9% Normal Saline measure: Preoperative blood glucose 30min measure: Postoperative blood glucose 30min measure: Postoperative nausea and vomiting measure: Postoperative nausea and vomiting measure: Postoperative nausea and vomiting measure: Postoperative nausea and vomiting measure: Anesthesia awakening time measure: Dizziness level measure: Dizziness level measure: Dizziness level measure: Quality of postoperative recovery (QoR40) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Lin Cheng status: RECRUITING city: Weifang state: Shandong zip: 261041 country: China name: Lin Cheng, B.S role: CONTACT phone: 17667404256 email: 1318216353@qq.com lat: 36.71 lon: 119.10194 hasResults: False
nctId: NCT06319131 id: Tipharosis briefTitle: Nadroparin Versus TIPS in Cirrhotic Patients With Refractory Asymptomatic PVT overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-30 date: 2026-05-30 date: 2024-03-19 date: 2024-03-21 name: Shanghai Zhongshan Hospital class: OTHER name: Shanghai 6th People's Hospital name: ShuGuang Hospital name: Tongji Hospital name: Renmin Hospital of Wuhan University briefSummary: The purpose of this study is to evaluate the comparative effectiveness of nadroparin versus transjugular intrahepatic portosystemic shunt in cirrhotic patients with refractory asymptomatic portal vein thrombosis using a design of a multicenter, randomized controlled trial conditions: Portal Vein Thrombosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 84 type: ESTIMATED name: TIPS name: Nadroparin measure: complete recanalization rate of PVT measure: partial recanalization rate of PVT measure: Bleeding rate measure: Mortality sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06319118 id: JD-LK2023091-I01 briefTitle: A Clinical Study of Dihydroergotine Mesylate Extended-release Tablets for the Treatment of Drooling in Parkinson's Disease. overallStatus: ACTIVE_NOT_RECRUITING date: 2023-10-01 date: 2024-06-30 date: 2024-12-30 date: 2024-03-19 date: 2024-03-19 name: Second Affiliated Hospital of Soochow University class: OTHER briefSummary: Objective: To evaluate the efficacy and safety of dihydroergotine mesylate extended-release tablets for salivation in Parkinson\'s disease Study content: Using a randomized, double-blind, placebo-controlled study design, 120 patients with Parkinson\'s disease and cognitive impairment were enrolled, and the treatment was followed up for 12 weeks: dihydroergotine mesylate sustained-release tablets + conventional treatment (treatment group patients, 80 cases), placebo + conventional treatment (control group patients, 40 cases), and the main indicators were observed: the improvement effect of dihydroergotine mesylate sustained-release tablets on PD salivation was observed, and the secondary indicators were observed: the effect of dihydroergotine mesylate sustained-release tablets on the cognitive function of PD patients was observed.
Expected results: The improvement effect of dihydroergotine mesylate sustained-release tablets on PD salivation was significantly different from that of the placebo control group. The dihydroergotine mesylate sustained-release tablet group had a significant effect on the cognitive function of PD patients. conditions: Salivation in Parkinson's Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 120 type: ESTIMATED name: Placebo name: dihydroergotine mesylate sustained-release tablets measure: the objective weight of saliva in patients with Parkinson's disease changed from baseline sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Second Arilliated Hospital of Soochow University city: Suzhou state: Jiangsu zip: 215004 country: China lat: 31.30408 lon: 120.59538 hasResults: False
nctId: NCT06319105 id: 775736 briefTitle: PathToScale: An Implementation Evaluation overallStatus: RECRUITING date: 2024-03-26 date: 2026-04-01 date: 2026-04-01 date: 2024-03-19 date: 2024-03-29 name: Georgetown University class: OTHER name: AIDS Vaccine Advocacy Coalition name: Centers for Disease Control and Prevention name: Center for the Development of People name: Cooper/Smith name: Elizabeth Glaser Pediatric AIDS Foundation name: Family Health Services name: Healthqual name: Johns Hopkins Research Project, Malawi name: Johns Hopkins Bloomberg School of Public Health name: Kamuzu University of Health Sciences name: Blantyre District Health Office, Malawi name: Lilongwe District Health Office, Malawi name: Lighthouse Trust name: Ministry of Health, Malawi name: National AIDS Commission, Malawi name: Pakachere Institute of Health and Development Communication name: Partners in Hope name: Population Services International name: University of North Carolina name: United States Agency for International Development (USAID) name: United States President's Emergency Plan for AIDS Relief name: Quantitative Engineering Design name: Clinton Health Access Initiative-Malawi briefSummary: The purpose of this study is to evaluate the implementation and clinical outcomes of expanded pre-exposure prophylaxis delivery modalities and service delivery points offering long-acting injectable cabotegravir and oral pre-exposure prophylaxis to high-priority groups through diverse delivery channels. conditions: Oral Pre-exposure Prophylaxis (PrEP) conditions: Long-acting Injectable Cabotegravir for PrEP studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 9900 type: ESTIMATED name: Standard intervention: Offer PrEP choice measure: Pre-exposure prophylaxis uptake by modality measure: Pre-exposure prophylaxis uptake by delivery channel measure: Pre-exposure prophylaxis uptake by population measure: Pre-exposure prophylaxis continuation by modality measure: Pre-exposure prophylaxis continuation by delivery channel measure: Pre-exposure prophylaxis continuation by population measure: Rates of switching between oral and injectable pre-exposure prophylaxis measure: Implementation readiness measure: Pregnancy rates among long-acting injectable cabotegravir for pre-exposure prophylaxis users measure: Pregnancy outcomes among long-acting injectable cabotegravir for pre-exposure prophylaxis users sex: ALL minimumAge: 15 Years maximumAge: 110 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Community Health Science Unit status: RECRUITING city: Lilongwe country: Malawi name: W Ozituosauka role: CONTACT lat: -13.96692 lon: 33.78725 hasResults: False
nctId: NCT06319092 id: 2023/175 briefTitle: Immersive Virtual Reality Version of the 6 Minute Pegboard and Ring Test overallStatus: COMPLETED date: 2023-06-01 date: 2023-10-01 date: 2023-12-01 date: 2024-03-19 date: 2024-03-19 name: Gaziantep Islam Science and Technology University class: OTHER briefSummary: The 6 Minute Pegboard and Ring Test is a test applicable to the upper extremities. The upper extremity plays an important role in activities of daily living, especially in tasks related to reaching, grasping and holding objects. Various activities of daily living, such as combing hair, brushing teeth and picking up objects, require supported or unsupported upper limb activity. Therefore, evaluation of upper extremity function is important. In addition, it is a simple test, it is also seen as a game, its application is functional, and there is no need for expensive equipment. Its validity and reliability have been demonstrated only for patients with Chronic Obstructive Pulmonary Disease (COPD) and healthy adults. In addition, to the best of our knowledge, the suitability of this test in a virtual environment has not been evaluated in the literature. Therefore, the main aim of this study is to examine the applicability of this test in a virtual environment. conditions: Healthy studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 30 type: ACTUAL measure: 6 Minute Pegboard and Ring Test measure: Immersive virtual reality version of the 6 Minute Pegboard and Ring Test measure: Quick Shoulder-Hand Syndromes Questionnaire measure: Assessment of handgrip measure: 9 Hole Peg Test sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Gaziantep İslamic Science and Technology University city: Gaziantep state: Şahinbey zip: 27000 country: Turkey lat: 37.05944 lon: 37.3825 hasResults: False
nctId: NCT06319079 id: UCTH 2024 briefTitle: Effect of Consumption of a Milk Product Designed for Lactating Women on Human Milk Composition overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-03 date: 2027-07 date: 2024-03-19 date: 2024-03-19 name: Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri class: OTHER briefSummary: Vulnerable populations, who have deficient diets, may produce human milk (HML) that is not adequate in all nutrients and this will have consequences on the growth and development of the child. In 2021 at IDIP, a specific milk product for pregnant and lactating women Super Mil Mamá ( SMM, whole milk powder fortified with multiple vitamins, minerals and DHA ) has been designed and developed as part of a key strategy to incorporate in public policies for the first 1000 days of life. However, the potential benefits of this product have not yet been evaluated at the population level.
To evaluate the relationship between the concentration of micronutrients in human milk and infant growth during the first six months of life. conditions: Lactating Mothers conditions: Infants studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QUADRUPLE maskingDescription: The powder milk containers (both SMM and commercial milk) will be packaged by Addvance SA (in the Province of Santa Fe), each of the products will have a label that differentiates them but only the company Addvance SA will know that information. In this project, neither the participating mothers, researchers, and technical staff assigned to the project nor the professional who performs the data analysis knows what product each participant will receive. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: Fortified powder milk name: Powder milk measure: breast milk DHA concentration measure: breast milk Vitamin A concentration measure: breast milk Vitamin E concentration measure: breast milk Vitamin D concentration measure: breast milk Zinc concentration measure: breast milk Calcium concentration measure: breast milk Iron concentration measure: breast milk Iodine concentration measure: mother red blood cell DHA concentration measure: mother Vit A concentration measure: mother Vit E concentration measure: mother Vit D concentration measure: mother Zinc concentration measure: mother hemoglobin concentration measure: mother serum ferritin concentration measure: child hemoglobin concentration measure: child serum ferritin concentration measure: child red blood cell DHA concentration sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06319066 id: RGNS65-152 briefTitle: Customized Foot Orthoses With Orthotic Wedges for Plantar Heel Pain overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-11-30 date: 2024-12-31 date: 2024-03-19 date: 2024-03-19 name: Mahidol University class: OTHER briefSummary: The present study will use a randomized controlled trial (RCT) to determine the effectiveness of customized foot orthosis (CFO) for the treatment of patients with PHP. Three treatment groups including the CFO without wedge, the CFO with wedge type 1 (W1), and the CFO with wedge type 2 (W2) will be randomly assigned to each participant by a computer-generated randomization. The opaque-sealed envelopes will be used to allocate the groups of participant. conditions: Foot Orthoses conditions: Fasciitis, Plantar studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescription: The present study will use a randomized controlled trial (RCT) to determine the effectiveness of CFO for the treatment of patients with PHP. Three treatment groups including the CFO without wedge, the CFO with W1, and the CFO with W2 will be randomly assigned to each participant by a computer-generated randomization. The opaque-sealed envelopes will be used to allocate the groups of participant. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Participants will be allocated to the control (CFO without wedge) or experimental (CFO with W1 or W2) groups according to the seal-envelop randomization technique. Then, they will be assessed all outcomes for the baseline including pain intensity, foot function, plantar fascia thickness, balance outcomes, and gait parameters by the 2nd physical therapist. And the participants will receive the assigned treatment by the 1st physical therapist. whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: orthotic wedge name: CFO measure: Pain intensity and foot function measure: Plantar Fascia Thickness measure: Gait assessment measure: Balance assessment measure: Low back and Lower-extremity pain measure: Transversus abdominis (TrA) Thickness measure: Subjective assessment measure: Physical assessment sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
nctId: NCT06319053 id: NL85402.078.23 briefTitle: The Turbine-based Insufflator Safety and Feasibility Study acronym: TBI overallStatus: RECRUITING date: 2024-03-04 date: 2024-09 date: 2024-10 date: 2024-03-19 date: 2024-04-10 name: Erasmus Medical Center class: OTHER name: Politecnico di Milano University name: Health∼Holland, Topsector Life Sciences & Health name: Spatium Medical B.V. name: IDE Group B.V. briefSummary: The turbine-based insufflator for minimal access surgery provides a new technological basis for minimal invasive surgery insufflation. Turbine technology permits highly accurate pressure control, an intra-abdominal volume that is dynamically adapted to ventilation, and oscillometric measurements of abdominal compliance. This first-in-human study aims to evaluate technologic feasibility in terms of pressure stability performance and the safety of the device. conditions: Laparoscopy conditions: Pneumoperitoneum studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SEQUENTIAL interventionModelDescription: Consecutive patients from who informed consent can be acquired. The number of twelve participants was determined in conjunction with the Ethical Board of Erasmus MC primaryPurpose: DEVICE_FEASIBILITY masking: NONE count: 12 type: ESTIMATED name: Turbine-based insufflator measure: Occurrence of (serious) adverse device effects [Safety and feasibility of the device] measure: Observation of insufflation pressure stability by continuously monitoring and recording. measure: Gas volume exchange measure: Estimation of the abdominal compliance measure: Intra-abdominal target pressure in relation to the abdominal compliance sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Erasmus MC, University Medical Center Rotterdam status: RECRUITING city: Rotterdam state: Zuid Holland zip: 3015 GD country: Netherlands name: J. Vlot, MD, PhD role: CONTACT phone: +31107039568 email: john.vlot@erasmusmc.nl name: A.I. de Jong, MD role: CONTACT phone: +31107037641 email: a.i.dejong@erasmusmc.nl lat: 51.9225 lon: 4.47917 hasResults: False
nctId: NCT06319040 id: MEDİPOL MEGA 1 briefTitle: The Effect Of Addıtıonal Surgery On Muscle Strength, Proprıoceptıon And Balance In Anterıor Crucıate Lıgament Surgery overallStatus: COMPLETED date: 2018-12-06 date: 2019-03-07 date: 2019-06-07 date: 2024-03-19 date: 2024-03-19 name: Medipol University class: OTHER briefSummary: Meniscal tears and RAMP lesions are frequently seen together with ACL injuries. The aim of this study was to evaluate the effects of meniscus repair and RAMP lesion repair ACL reconstruction surgery in terms of muscle strength, proprioception, and balance. In our study, the clinical outcomes of both anterior cruciate ligament reconstruction (ACLR), medial meniscus repair (MR) and RAMP lesion repair (RR) have been compared with those of isolated ACLR. conditions: Anterior Cruciate Ligament Injuries conditions: Meniscus Lesion studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 45 type: ACTUAL name: Muscle strength measurement name: Knee joint proprioception name: Balance name: Fall risk test name: Tegner Activity Level name: Lysholm Knee Scoring Scale measure: muscle strength measurement sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Istanbul Medipol University city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False