nctId: NCT06285474 id: 22-001323 briefTitle: Investigating LIFUP in Anhedonic Depression acronym: ILIAD overallStatus: ENROLLING_BY_INVITATION date: 2022-10-27 date: 2024-04-30 date: 2024-04-30 date: 2024-02-29 date: 2024-02-29 name: University of California, Los Angeles class: OTHER name: Wellcome Trust briefSummary: This study will observe changes in brain imaging, behavior, and symptom measures following intervention with low intensity focused ultrasound pulsation (LIFUP) targeting reward circuitry in individuals who are depressed and anhedonic. conditions: Depression conditions: Anhedonia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 46 type: ESTIMATED name: Low Intensity Focused Ultrasound Pulsation (LIFUP) measure: Change in Patient health questionnaire-14 self report measure (PHQ-14) from baseline measure: Change in Positive valence systems scale-21 self report measure (PVSS-21) from baseline measure: Changes in MRI images from Pre-scan to week 5 measure: Change in Ecological momentary assessment (EMA) from W0/Baseline measure: Changes in digital behavioral phenotype sleep measurement measure: Changes in digital behavioral phenotype physical activity measurement measure: Changes in heart rate measure: Changes in heart rate variability measure: Changes in respiratory rate measure: changes in World Health Organization (WHO) -5 Wellbeing index score from W0/Baseline to end of study measure: changes in Pittsburgh Sleep Quality Index (PSQI) score from W0/Baseline to end of study measure: changes in Quick Inventory of Depressive Symptoms (QIDS-SR15) score from W0/Baseline to end of study measure: changes in Patient Health Questionnaire (PHQ-9) score from day 2 to week 2 measure: changes in Brief Irritability Test (BITe) score from W0/Baseline to end of study measure: changes in Generalized Anxiety Disorder (GAD-7) score from W0/Baseline to end of study measure: Changes in Snaith Hamilton Pleasure Scale (SHAPS) score from W0/Baseline to end of study measure: Changes in Suicidal Ideation measure from Pre-scan to end of study measure: changes in Apathy Motivation Index (AMI) score from W0/Baseline to end of study measure: changes in Eudaimonic Well-Being Questionnaire (EWBQ) score from W0/Baseline to end of study measure: Changes in Work and Social Adjustment Scale (WSAS) score from W0/Baseline to end of study measure: Changes in Ruminative Response Scale (RRS) - brooding subscale score from W0/Baseline to end of study measure: changes in Trauma History Questionnaire (THQ) score from W0/Baseline to end of study measure: changes in Routines Survey from W0/Baseline to end of study measure: changes in USDA Housing and Food Insecurity score from W0/Baseline to end of study measure: changes in Holmes-Rahe Life Stress Survey score from W0/Baseline to end of study measure: Changes in emotion recognition accuracy scores from Pre-scan to end of study measure: Changes in emotion recognition response times from Pre-scan to end of study measure: Changes in continuous concentration accuracy scores from Pre-scan to end of study measure: Changes in continuous concentration response times from Pre-scan to end of study measure: Changes in continuous concentration error scores from Pre-scan to end of study measure: Changes in Apple Gathering task behavior from Pre-scan to end of study sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of California Los Angeles city: Los Angeles state: California zip: 90095-1563 country: United States lat: 34.05223 lon: -118.24368 hasResults: False