hackint0sh/New-Dataset huggingface dataset:
* N-803 (a type of recombinant human IL-15 superagonist) conditions: Renal Carcinoma conditions: Renal Cell Carcinoma conditions: Urothelial Carcinoma studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 5 type: ESTIMATED name: Cytokine Induced Memory-like Natural Killer (CIML NK) Cells name: N-803 measure: Feasibility Failure Rate (FFR) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Brigham and Women's Hospital city: Boston state: Massachusetts zip: 02215 country: United States name: Wenxin Xu, MD role: CONTACT phone: 617-632-6534 email: wenxin_xu1@dfci.harvard.edu name: Wenxin Xu, MD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Dana-Farber Cancer Institute city: Boston state: Massachusetts zip: 02215 country: United States name: Wenxin Xu, MD role: CONTACT phone: 617-632-6534 email: Wenxin_Xu1@dfci.harvard.edu name: Wenxin Xu, MD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06318858 id: MU-CIRB 2022/313.1411 briefTitle: Daily and Weekly Iron Supplementation in Infants overallStatus: RECRUITING date: 2023-03-15 date: 2024-08-14 date: 2024-10-14 date: 2024-03-19 date: 2024-04-05 name: Mahidol University class: OTHER name: Suranaree University of Technology briefSummary: This study aims to compare the efficacy of daily iron supplementation and weekly iron supplementation in infants aged 6-12 months on the prevalence of anemia, hemoglobin level, and serum ferritin levels. Infants will be enrolled at 6 months and will be randomly assigned to receive either daily or weekly iron supplementation for the first 3 months and will be followed by weekly iron supplementation for another 3 months. conditions: Anemia conditions: Iron Status conditions: Infants conditions: Iron studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: group 1: daily iron syrup supplementation group 2: weekly iron syrup supplementation primaryPurpose: PREVENTION masking: TRIPLE maskingDescription: Letter codes were assigned to the iron syrup and the placebo by researchers who have not involved in the study. The codes have been kept until data analysis and report writing are complete. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 300 type: ESTIMATED name: Iron supplement measure: Anemia status measure: Iron status measure: Weight measure: Length measure: Dietary intake measure: Head circumference (HC) measure: Hemoglobin typing measure: C-reactive protein (CRP) measure: Alpha-1 acid glycoprotein (AGP) measure: Serum transferrin receptor measure: Serum Retinol Binding Protein (RBP) sex: ALL minimumAge: 6 Months maximumAge: 12 Months stdAges: CHILD facility: Samphran District Hospital status: RECRUITING city: Sam Phran state: Nakhon Pathom zip: 73110 country: Thailand name: Tinnakorn Chuenchom, MD role: CONTACT phone: 6634311021 phoneExt: 105 name: Somchai Janelapwattanakul, MD role: CONTACT phone: 6634352052 phoneExt: 4001 lat: 13.72698 lon: 100.21526 hasResults: False
nctId: NCT06318845 id: 2302CS-1 briefTitle: Phase 1 Study to Evaluate the Safety and Pharmacokinetic Drug Interaction of DHP2302R1 and DHP2302R2 overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-04 date: 2024-07-19 date: 2024-08-02 date: 2024-03-19 date: 2024-03-19 name: Daehwa Pharmaceutical Co., Ltd. class: INDUSTRY briefSummary: The purpose of this study is to investigate the safety and drug interaction of DHP2302R1 and DHP2302R2 when administered alone versus in combination in healthy South Korean adult participants. conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: PREVENTION masking: NONE count: 42 type: ACTUAL name: DHP2302R1 name: DHP2302R2 measure: AUClast of DHP2302R1 and DHP2302R2 measure: Cmax of DHP2302R1 and DHP2302R2 measure: Tmax of DHP2302R1 and DHP2302R2 measure: AUC0-48 of DHP2302R1 and DHP2302R2 measure: AUCinf of DHP2302R1 and DHP2302R2 measure: t1/2 of DHP2302R1 and DHP2302R2 measure: CL/F of DHP2302R1 and DHP2302R2 measure: Vz/F of DHP2302R1 and DHP2302R2 sex: ALL minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT facility: H Plus Yangji Hospital city: Seoul state: Gwanak-gu zip: 08779 country: Korea, Republic of lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06318832 id: 124609 briefTitle: Optimizing a Wellbeing Program for Care-partners of Those With SCI overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2024-06 date: 2025-06 date: 2024-03-19 date: 2024-03-19 name: Lawson Health Research Institute class: OTHER briefSummary: Spinal cord injuries (SCI) have a devastating effect not only on individuals incurring the life changing event, but also on those who are involved in their care. Family care-partners of those with SCI (fcSCI) may experience significant negative effects including impaired mental health, high levels of burden, poor adjustment to role, decreased quality of life and strain on relationships. Cognitive behaviour therapy (CBT) is an evidence-based treatment strategy that helps individuals recognize and challenge their unhelpful thoughts and behaviours that contribute to their mental health concerns. However, barriers such as availability to specialized care, costs, rural and remote location, or concerns about stigma may limit access to care. Internet delivered CBT (ICBT) has the potential to reach a much wider group of people that may have unequal access to health care.
In a previous feasibility study, the team demonstrated the preliminary effectiveness of a tailored ICBT Wellbeing program for fcSCI. However, our understanding of which components of the program can result in optimal management is limited. The main purpose of this study is to evaluate the effectiveness of different components of the Wellbeing program including: therapist guidance, peer support groups, and booster sessions on symptoms of depression among fcSCI. The team will evaluate which intervention components result in meaningful improvement in symptoms of depression. Through collaborations with SCI community organizations and rehabilitation institutions, participants will be recruited across Canada. The researchers will also develop a model to examine the most cost-effective intervention package from the different components. The Wellbeing for fcSCI program can provide personalized service to individuals while being flexible and easily accessible, improving overall wellbeing and access to health care services. conditions: Internet-Delivered Cognitive Behavioural Therapy conditions: Depression conditions: Anxiety conditions: Spinal Cord Injuries conditions: Caregiver Burnout studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: TREATMENT masking: NONE count: 154 type: ESTIMATED name: ICBT measure: Change in depression sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06318819 id: 159-11-19. briefTitle: Plaque Removal Effectiveness of a Flossing Device Compared to the Conventional Flossing in Adults overallStatus: COMPLETED date: 2019-11-01 date: 2020-03-15 date: 2020-05-31 date: 2024-03-19 date: 2024-03-20 name: Maha A. Bahammam class: OTHER name: King Abdulaziz University briefSummary: * Objective: To evaluate the effectiveness in plaque removal of the new device; Dental floss holders and compare the results to the conventional way of flossing.
* Methods: Thirty adult male and female participants participated in this randomized, single-use, single-blind clinical study. Participants were randomly assigned to one of two groups; Group A: Consists of 30 participants in whom Dental Floss Holders (DFH) was constructed to either maxillary or mandibular arch randomly. Group B: Consists of 30 participants in whom conventional flossing (CF) was done to the other arch.
Participants attended the first visit for primary impression taking in order to construct the DFH. In the second visit, participants were examined by a blinded examiner to record their plaque index using O'Leary index. Then, they flossed using DFH and CF according to the group they were assigned to. Participants were monitored to ensure proper coverage of all the areas following precise instructions. They then brushed their teeth for approximately 2 minutes using modified bass technique. Next, plaque index was recorded again using the O'leary index. Time was recorded during flossing of each arch. Finally, participants were given a questionnaire to assess their satisfaction of the device.
* Results: The differences between the groups showed the DFH group with a 62.8% reduction in whole mouth plaque and 63.3% for proximal plaque compared to 52.9% and 50.4% for the CF group, respectively (p = 0.01). The DFH was more time efficient in removing plaque from the marginal regions with an average time of 00:00:37 in comparison to the CF which averaged in 00:02:07 (p \< 0.001). A total of 26 participants (86.7%) preferred using the DFH over the CF.
* Conclusion: With the combination of toothbrushing, the Dental Floss Holders is significantly more effective and time efficient than conventional flossing in removing plaque from tooth surfaces. conditions: Tooth Decay conditions: Cavities of Teeth conditions: Gingivitis conditions: Plaque studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 30 type: ACTUAL name: Dental Floss Holders measure: Dental Floss Holders (DFH) measure: Conventional flossing (CF) sex: ALL minimumAge: 20 Years maximumAge: 26 Years stdAges: ADULT facility: King Abdulaziz University city: Jeddah country: Saudi Arabia lat: 21.54238 lon: 39.19797 hasResults: False
nctId: NCT06318793 id: 2024Ao001* briefTitle: Preoperative Inflammatory Markers Predict Postoperative Complications After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Colorectal Carcinomatosis overallStatus: COMPLETED date: 2012-09 date: 2023-07 date: 2023-12 date: 2024-03-19 date: 2024-03-20 name: CHU de Reims class: OTHER briefSummary: A retrospective study of a single-center prospective database of patients who underwent curative CRS-HIPEC for peritoneal carcinomatosis (PC) of colo-rectal cancer (CRC), between September 2012 and July 2023 at Reims Hospital-University was conducted. Inclusion criteria were: patients older than 18 years with a performance status ≤ 2, who underwent complete (no macroscopic residual disease) CRS-HIPEC was performed. Exclusion criteria were the presence of an infectious disease prior to surgery, CRS without HIPEC, incomplete CRS and expressed refusal to participate in the study.
Variables with a normal distribution are presented as mean-SD, while those with a non-normal distribution are presented as median and range. Categorical variables are presented as counts and percentages. Chi-Square or Fisher's exact test was used to compare qualitative variables. Linear regression analysis was used to assess any association between preoperative inflammatory biomarkers and patient comorbidities and disease characteristics. Preoperative levels of inflammatory biomarkers were compared between patients with no postoperative complication (POC) and patients with POC and major POC using the non-parametric Mann-Whitney U test. Optimal cut-off values for significant inflammatory biomarkers were determined using the Youden index. Receiver operating curves (ROC) were calculated to determine the area under the curve (AUC). Univariable and multivariable analyses including cut-off values of significant biomarkers were performed in a binary logistic regression analysis and expressed as odds ratios (OR). All tests were two-tailed and results were considered significant if the p-value was \< 0.05. Statistical analyses were performed using R software (version 4.0.5). conditions: Peritoneal Carcinomatosis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 166 type: ACTUAL measure: Concentration of C-reactive protein (CRP) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chu Reims city: Reims zip: 51092 country: France lat: 49.25 lon: 4.03333 hasResults: False
nctId: NCT06318780 id: PI2023_843_0171 briefTitle: Concordance of Three Imaging Methods by Dynamic CT, Contrast Ultrasound and CT Angiography in the Characterization of Endoleaks in Patients With an Aortic Endoprosthesis acronym: LEAKDYN overallStatus: RECRUITING date: 2024-02-28 date: 2029-02 date: 2031-02 date: 2024-03-19 date: 2024-03-19 name: Centre Hospitalier Universitaire, Amiens class: OTHER briefSummary: Among patients who have undergone EVAR, there is a significant risk of 20-50% endoleak. These endoleaks often require secondary interventions to reduce the risk of expansion or rupture. Currently, three-phase CT angiography and CEUS ultrasound are recommended in the post-operative monitoring of EVAR but these remain limited in characterizing the type and source of endoleak. In this study the investigators will study the interest of d-CTA for a better detection and characterization of endoleaks. conditions: Aortic Diseases studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 69 type: ESTIMATED name: three-phase CT angiography name: CEUS ultrasound measure: Endoleak classification using the CT angiography measure: Variation of Endoleak classification between CEUS ultrasound and the CT angiography sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU Amiens Picardie status: RECRUITING city: Amiens state: Picardie zip: 80054 country: France name: Thierry REIX, PhD role: CONTACT phone: +33322455929 email: reix.thierry@chu-amiens.fr lat: 49.9 lon: 2.3 hasResults: False
nctId: NCT06318767 id: PI2023_843_0141 briefTitle: Predictive Value of Systolic Rise Time of the Plantar Arch on the Risk of Major Adverse Limb Events (MALE) and Major Adverse Cardiovascular Events (MACE) in Peripheral Artery Disease (PAD) at Critical Ischaemia Stage acronym: TAMIS overallStatus: RECRUITING date: 2024-03-04 date: 2025-03 date: 2025-09 date: 2024-03-19 date: 2024-03-19 name: Centre Hospitalier Universitaire, Amiens class: OTHER briefSummary: Peripheral artery disease (PAD), vascular disease of atheromatous origin, is a frequent pathology, with a steady and significant increase in prevalence over the last decades. It has various symptoms ranging from mild arterial claudication to critical limb ischemia. The critical ischaemia stage in PAD is defined by rest pain or trophic disorders and is a special situation because of the number of cardiovascular deaths at 1 year (25%), 60% at 5 years and acute ischaemic recurrence at 1 year (25%).
It is a medico-surgical pathology. A haemodynamic marker is needed to monitor patients, as it is predictive of limb progression, cardiovascular events and mortality. The Systolic Rise Time (SRT) of the plantar footpad is a recently described haemodynamic measurement of proven value in the diagnosis of PAD. The aim of this study is to show the prognostic value of the Systolic Rise Time on Major Adverse Limb Events (MALE). conditions: Major Adverse Limb Events conditions: Major Adverse Cardiovascular Events conditions: Peripheral Artery Disease conditions: Critical Limb Ischemia conditions: Hemodynamic Measure studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 134 type: ESTIMATED name: hemodynamic measure of the Systolic Time Rise measure: occurrence of limb ischemia sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU Amiens status: RECRUITING city: Amiens zip: 80480 country: France name: SOUDET Simon, MD role: CONTACT phone: 03 22 88 72 89 email: soudet.simon@chu-amiens.fr lat: 49.9 lon: 2.3 hasResults: False
nctId: NCT06318754 id: HP-00104241 briefTitle: Large-Bore Mechanic Thrombectomy for the Treatment of Symptomatic Portomesenteric Vein Thrombosis overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-09 date: 2026-06 date: 2024-03-19 date: 2024-03-19 name: University of Maryland, Baltimore class: OTHER name: Inari Medical briefSummary: A single site study evaluating the safety, feasibility, and effectiveness of percutaneous large-bore mechanical thrombectomy using the Inari Triever Aspiration Catheter for the treatment of portomesenteric vein thrombosis (PMVT). conditions: Thrombosis conditions: Thrombectomy conditions: Portal Vein studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 10 type: ESTIMATED name: Inari Triever Aspiration Catheter measure: Technical Success measure: Clinical Success measure: Primary Patency measure: Intermediate functional success measure: Secondary Patency measure: Duration of hospitalization measure: Duration of ICU days measure: Blood loss during intervention measure: Transfusion measure: Major and minor complications measure: 30-day mortality sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06318728 id: CAEE - 70162723.0.0000.8093 briefTitle: Musculotendinous Adaptations in High and Low- Performance Triathletes acronym: MAT overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-07-16 date: 2024-10-04 date: 2024-03-19 date: 2024-03-19 name: University of Brasilia class: OTHER briefSummary: This study aims to investigate the musculotendinous adaptations in the Achilles tendon and the muscles composing the triceps surae induced by triathlon training and competitions in high-performance and low-performance athletes. Twenty high-performance triathletes, twenty low-performance triathletes, and twenty physically active and healthy individuals of both genders will be recruited to constitute the research groups. Ultrasonography will be employed as the assessment method for the structures of the Achilles tendon and the muscular architecture of the triceps surae. The quality and portability of ultrasonography, coupled with its real-time information capabilities, make it the appropriate choice for this evaluation. The VISA-A scale (Victorian Institute of Sport Achilles Assessment) will be used to measure pain and function of the Achilles tendon. The reliability of ultrasonography measures will be obtained by evaluating images of individuals using the intraclass correlation coefficient, allowing for the analysis of result reproducibility. Data analysis will involve comparisons among the high-performance, low-performance, and physically active groups, aiming to identify differences in musculotendinous adaptations related to performance and injury predisposition. Structural changes occurring in these structures and their potential association with sports performance and/or injury predisposition will be explored. Overall, this study utilizes a comparative cross-sectional research design, where different groups are assessed regarding musculotendinous adaptations in the Achilles tendon and triceps surae through ultrasound-derived measures. The use of the VISA-A scale and the assessment of measure reliability will provide additional data on pain, function, and result reproducibility. conditions: Athletes studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ESTIMATED measure: Morphological Properties: Tendon Length (TL). measure: Evaluation of Achilles Tendon Shape (fusiform or parallel) measure: Echogenicity of the Tendon (homogeneous and heterogeneous areas) measure: Mechanical properties of the Achilles Tendon: Force measure: Mechanical properties of the Achilles Tendon: Stress measure: Mechanical properties of the Achilles Tendon: Strain measure: Material Properties of the Achilles Tendon: Elastic Modulus measure: Muscle Thickness measure: Muscle Properties: Pennation Angle (PA) measure: Muscle Properties: Fascicle Length (FL) measure: Muscle Echogenicity measure: Assessment of Muscle Electrical Activation measure: Muscle Torque Evaluation measure: Evaluation of Muscle and Achilles Tendon Stiffness through 2D Shear Wave Elastography (SWE): measure: Ankle pain and function sex: ALL minimumAge: 17 Years maximumAge: 52 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06318715 id: 23-0009-A briefTitle: Modified Deep Extubation vs. Standard Awake Extubation acronym: mDE overallStatus: RECRUITING date: 2024-04-03 date: 2024-12 date: 2025-03 date: 2024-03-19 date: 2024-04-18 name: Samuel Lunenfeld Research Institute, Mount Sinai Hospital class: OTHER briefSummary: The proposed study is to compare a modified DE technique, which is regularly used for low-risk patients by staff anesthesiologists at our institution, to a standard awake extubation. This modified deep extubation (mDE) occurs while the patient is still anaesthetized but at a lower dose of anaesthetic gas than previously described, and balanced with long acting opioids to attenuate the airway reaction. As previously stated, the literature shows that the risks of DE are equivalent to those of regular AE practice. Our hypothesis is that mDE will shorten the time from the end of the surgery (completion of last stitch) to the moment the patient is ready to leave the OR by at least 5 minutes when compared to standard AE practice. conditions: Extubation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: modified deep extubation (mDE) name: standard awake extubation measure: Time from the end of the surgery to leaving the OR measure: Time from the end of the surgery to extubation measure: Time from the end of the surgery to discharge from PACU measure: oral airway measure: jaw-thrust maneuver measure: hypertension measure: breath holding measure: bag-mask ventilation measure: coughing measure: bucking measure: laryngospasm measure: treat laryngospasm measure: desaturation measure: reintubation measure: Patient's experience measure: BP measure: HR measure: EtCO2 measure: SaO2 measure: Sevorane MAC sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Anesthesia Mount Sinai Hospital status: RECRUITING city: Toronto state: Ontario zip: M5G 1X5 country: Canada name: Naveed Siddiqui, MD role: CONTACT phone: 416-586-4800 phoneExt: 5270 email: naveed.siddiqui@uhn.on.ca name: Naveed Siddiqui, MD role: PRINCIPAL_INVESTIGATOR lat: 43.70011 lon: -79.4163 hasResults: False
nctId: NCT06318702 id: 2023-KAEK-180 briefTitle: The Effect of Constructivist Learning Model Based Gynecological Cancer Education overallStatus: COMPLETED date: 2023-12-25 date: 2024-01-20 date: 2024-02-20 date: 2024-03-19 date: 2024-03-20 name: Kastamonu University class: OTHER briefSummary: This is a randomised controlled study.The study was conducted to determine the effect of the constructivist education model given to women on gynecological cancer awareness, health Anxiety and spiritual well-being in women . The study population was composed of women living in Kastamonu. Women will be assigned to control and experimental groups. Women in the control group will receive gynecological education from Cancer Early Diagnosis, Screening and Education Centers (KETEM). The other group will receive gynecological cancer education based on the constructivist model.The hypotheses of the study are as follows:
H1: The of constructivist learning model -based health education programme have an effect on gynecologic cancer awareness, spiritual well-being and health anxiety. conditions: Gynecologic Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: NONE count: 107 type: ACTUAL name: Education measure: gynecologic cancer awareness measure: spiritual well-being measure: health anxiety scores sex: FEMALE minimumAge: 18 Years maximumAge: 69 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kastamonu University city: Merkez state: Kastamonu zip: 37150 country: Turkey hasResults: False