hackint0sh/New-Dataset huggingface dataset:
The general objective of the project is to study how the adaptive immune response evolves against SARS-CoV-2 with repeated vaccination boosters and infections also in relation to the evolution of variations. This study will be relevant to frail populations who are the main targets of repeated vaccinations. Our project will benefit from the availability of a highly cohort characterized of vaccinated people, including cancer patients and elderly people, with prospective collection of samples for an in-depth evaluation of the evolution of the immune response with repeated exposure to doses of infection or vaccine. As part of the study, analyzes will be carried out on samples of patients enrolled in a manner prospective at the oncology departments of the IRCCS (Medical Oncology, Department of Radiotherapy advanced oncology and nuclear medicine) and elderly patients residing in retirement homes of the IRCCS. Patients will also be asked for consent to store any residual samples in the Tropica DITM Biobank. conditions: COVID-19 studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: NONE count: 350 type: ESTIMATED name: Analisys of cellular response and humoral response to SARS-CoV-2 vaccine booster doses measure: Cellular response evaluation: flow cytometry profiles (proportions of cells) measure: Cellular response evaluation: results of T and B cells stimulation with specific peptides (continuous variables, unity of measure: Optical Density OD) measure: Cellular response evaluation: ADCC assay (continuous variables, unity of measure: Optical Density OD) measure: Cellular response evaluation: anti-SARS-CoV-2 antibodies quantities (IgGs and IgM, BAU/ml) measure: Cellular response evaluation: neutralization assays against different SARS-CoV-2 variants (continuous variables, unity of measure: TCID50/ml) measure: Cellular response evaluation: avidity assays (continuous variables, unity of measure: BAU/ml). measure: Humoral response evaluation: anti-SARS-CoV-2 antibodies quantities (IgGs and IgM, BAU/ml) measure: Humoral response evaluation: neutralization assays against different SARS-CoV-2 variants (continuous variables, unity of measure: TCID50/ml) measure: Humoral response evaluation: avidity assays (continuous variables, unity of measure: BAU/ml). measure: Neutralization assays against different human Coronavirus (hCoV). measure: Whole genome sequencing analysis results sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Sacro Cuore Don Calabria hospital status: RECRUITING city: Negrar state: Verona zip: 37024 country: Italy name: Chiara Piubelli role: CONTACT phone: +390456013706 email: chiara.piubelli@sacrocuore.it name: Chiara Piubelli role: PRINCIPAL_INVESTIGATOR name: Stefania Gori role: SUB_INVESTIGATOR lat: 45.52918 lon: 10.93899 hasResults: False
nctId: NCT06300840 id: 2023_49 id: NL84562.075.23 type: OTHER domain: METC ISALA briefTitle: Vibrotactile Feedback Belt in Patients With Unilateral Vestibular Hypofunction (UVH) acronym: VIBE overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-04 date: 2025-04 date: 2024-03-08 date: 2024-03-08 name: Hanna van Eijsden class: OTHER briefSummary: The goal of this clinical trial is to study the impact of a continuous vibrotactile feedback belt on balance, (fear of) falling, fatigue and overall functioning in participants with chronic disabling unilateral vestibular hypofunction.
It is expected that, just as with patients with bilateral loss of the balance organ, patients with a unilateral loss will also benefit from the BalanceBelt. conditions: Vestibular Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Single-case-experiment (SCE) with a reversal design and with randomization of phases. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Data-analyst and test-observer are masked whoMasked: OUTCOMES_ASSESSOR count: 8 type: ESTIMATED name: BalanceBelt measure: Mobility and Balance Score (MBS) measure: General functioning measure: physical activity_NRS measure: physical activity_steps measure: Fear of falling measure: fatigue measure: falls measure: structured interview on compliance on wearing the Balancebelt(R) measure: Questionnaire: vestibular activity avoiding instrument (VAAI) measure: Questionnaire: Dizziness handicap inventory (DHI) measure: modified Clinical Test of Sensory Interaction on Balance (mCTSIB) measure: Dynamic Gait Index (DGI) measure: Timed up and Go test (TUG) measure: age measure: time since onset of the vestibular hypofunction measure: cause of vestibular hypofunction measure: Structured interview on vestibular rehabilitation measure: outcome of the vestibular function tests measure: Structured interview on participating in the research measure: Structured interview on the overall experience with the Balancebelt(R) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Gelre Hospitals city: Apeldoorn state: Gelderland zip: 7334 DZ country: Netherlands lat: 52.21 lon: 5.96944 hasResults: False
nctId: NCT06300827 id: 2023 - 1302 briefTitle: The Effect of Structured Digital-Based Education Given to Nursing Students overallStatus: RECRUITING date: 2024-03-01 date: 2024-06-01 date: 2024-12-01 date: 2024-03-08 date: 2024-03-08 name: Gazi University class: OTHER name: The Scientific and Technological Research Council of Turkey briefSummary: Turkey is a risky country in terms of disasters. Preparedness and awareness for all disasters affecting the whole world gain value. Disaster literacy is an important approach to evaluating disaster preparedness and awareness processes. Disaster literacy is defined as the ability of an individual to access, read, understand, and use the information necessary to make informed decisions and follow instructions in the context of mitigation, preparation, response, and recovery during a disaster Disaster literacy needs to be increased to raise awareness among individuals and minimize disaster risk. Along with the awareness studies, it is also important to identify the disaster preparedness belief in order to encourage individuals to change potentially harmful behavior. Belief in disaster preparedness; It may vary according to the perception of experiencing a disaster, the perceived severity of the disaster, the benefits of being prepared for a disaster, the perceived barriers to being prepared for a disaster, being prepared, and the individual's belief in his or her ability to cope with a disaster. It may be useful to determine both disaster preparedness beliefs and disaster literacy levels of individuals at the social level. It is predicted that when multiple interventions are brought together in the learning process, there will be a faster and more lasting effect. In this study, which aims to use education and information technology together, a structured digital-based educational intervention is planned. The intervention program was structured by taking advantage of both the advantages of the digital world and active learning methods in order to keep the student active. The program is eight weeks and consists of seven dimensions and the purpose of the program is based on accessing information, understanding, information, making decisions, and applying information. The planned study aimed to determine the effect of structured digital-based education given to university students studying in the nursing department on their disaster literacy and disaster preparedness belief levels. conditions: 18 Years and Over studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Experimental Group: Structured digital-based training will be implemented. Control Group: The nursing student will be expected to continue their daily life.
Nursing students who meet the inclusion criteria will be randomly assigned to the experimental group by a statistician. primaryPurpose: PREVENTION masking: SINGLE maskingDescription: Research data/output measurements are made by a research assistant not involved in the research. whoMasked: OUTCOMES_ASSESSOR count: 76 type: ESTIMATED name: Structured digital-based training measure: Disaster Literacy Scale measure: General Disaster Preparedness Belief Scale Using the Health Belief sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Gazi University status: RECRUITING city: Ankara country: Turkey name: Aysun Erdal, Ph. D. (c) role: CONTACT phone: +905367655107 email: aysunmutlu25@gmail.com lat: 39.91987 lon: 32.85427 facility: Necmettin Erbakan University status: RECRUITING city: Konya country: Turkey name: Fatma Zehra Genç, Ph. D. role: CONTACT phone: +905063216816 email: fatmazehragnc@gmail.com lat: 37.87135 lon: 32.48464 facility: Tokat Gaziosmanpaşa University status: RECRUITING city: Tokat country: Turkey name: Suzan Yıldız, Ph. D. role: CONTACT phone: +905444794647 email: suzanmola@hotmail.com lat: 40.31389 lon: 36.55444 hasResults: False
nctId: NCT06300814 id: ERU-HEM-EU-01 briefTitle: The Effect of Exercise and Music on Sleep, Quality of Life and Emotional State in Children With Epilepsy overallStatus: RECRUITING date: 2024-03-01 date: 2024-03-01 date: 2024-12-01 date: 2024-03-08 date: 2024-03-08 name: TC Erciyes University class: OTHER briefSummary: This study was planned as a randomized controlled experimental study with a pretest-posttest design to determine the effect of parental supervision and video-guided progressive relaxation exercise (PRE) and music recital on sleep, quality of life and emotional states in children with epilepsy aged 9-16 years. The main questions it aims to answer are as follows:
According to the evaluation of children with epilepsy, does the progressive relaxation exercise applied to children have an effect on sleep, quality of life and emotional states? According to the evaluation of children with epilepsy, does music recital applied to children have an effect on sleep quality of life and emotional states? The study consisted of 45 children (15 children in the progressive relaxation exercise group, 15 children in the music recital group and 15 children in the control group). Ethics committee approval, permission from the institutions and informed consent of the children were obtained for the conduct of the study. A value of p\<0.05 was considered statistically significant in data analysis. conditions: Epilepsy in Children studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: PARTICIPANT count: 45 type: ESTIMATED name: Progressive relaxation exercise group name: Music recital group measure: The Children's Sleep Habits Questionnaire (CSHQ) measure: The Pediatric Quality of Life Inventory (PedsQL) measure: The Me and My School Questionnaire (M&MS) sex: ALL minimumAge: 9 Years maximumAge: 16 Years stdAges: CHILD facility: Erciyes University status: RECRUITING city: Kayseri country: Turkey lat: 38.73222 lon: 35.48528 hasResults: False
nctId: NCT06300801 id: 2023-48 briefTitle: Postoperative Pancreatic Fistula in Patients Undergoing Pancreaticoduodenectomy acronym: popf overallStatus: NO_LONGER_AVAILABLE date: 2024-03-08 date: 2024-03-08 name: Erol Olcok Corum Training and Research Hospital class: OTHER briefSummary: Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality. Postoperative pancreatic fistula (POPF) is the most common and clinically significant complication following PD. In this study, the investigators aim to predict pancreatic fistula using the C-reactive protein-albumin ratio (CAR). The total number of participants expected to be included in this research comprises patients who underwent PD between 2017 and 2023 and developed pancreatic fistula. The participants invitation is based on the detection of a pancreatic fistula. This study is conducted for research purposes and participation is voluntary. No interventions will be performed on the participants as part of this study; however, we have prepared this form to obtain participant permission to gather certain information. If the participants consent to the use of information for scientific purposes with the guarantee of confidentiality, they will be asked to sign a consent form. conditions: Pancreatic Fistula After Pancreaticoduodenectomy conditions: C-Reactive Protein conditions: Albumin studyType: EXPANDED_ACCESS sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06300788 id: 23-AOI-02 briefTitle: Inorganic Pyrophosphate Homeostasis (PPi) in Pediatric Chronic Kidney Disease acronym: PPi-DIA overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-10-01 date: 2024-10-01 date: 2024-03-08 date: 2024-03-08 name: Centre Hospitalier Universitaire de Nice class: OTHER briefSummary: The investigator aim to identify the role of inorganic pyrophosphate and other anti-calcifying molecules in vascular disease in children with chronic kidney disease, with a view to developing therapeutic approaches aimed at limiting the onset of vasculopathy. conditions: Pyrophosphate, Fetuin A, IL1, IL6, TNFalpha, Control studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 60 type: ESTIMATED name: PPI and T50 dosing measure: Plasma pyrophosphate concentration [PPi]pl in children with CKD measure: Plasma pyrophosphate [PPi]pl concentration in children with renal transplantation measure: Markers of phosphocalcic metabolism measure: Urinary PPi concentration measure: Markers of vascular damage in CKD sex: ALL minimumAge: 0 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: CHU Nice - Hôpital de l'Archet 2 city: Nice state: Alpes-Mritimes zip: 06300 country: France name: Julie BERNARDOR role: CONTACT phone: 04.92.03.63.65 phoneExt: +33 email: bernardor.j@chu-nice.fr lat: 43.70313 lon: 7.26608 hasResults: False
nctId: NCT06300775 id: 123789 briefTitle: Evaluation of Modified Hyrax Versus Quad Helix in Treatment of Posterior Cross Bite overallStatus: RECRUITING date: 2024-06-01 date: 2025-05-01 date: 2025-06-01 date: 2024-03-08 date: 2024-03-08 name: Cairo University class: OTHER briefSummary: This study will be performed to evaluate the treatment of posterior cross-bite with modified hyrax \& Quad helix appliances and to compare which one will provide better results in relation to chewing difficulty in children with posterior cross- bite in mixed dentition conditions: Posterior Cross Bite studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Modified Hyrax Versus Quad Helix primaryPurpose: TREATMENT masking: NONE maskingDescription: no Masking count: 10 type: ESTIMATED name: modified hyrax name: quad helix measure: Chewing difficulty sex: ALL minimumAge: 6 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Cairo univeristry status: RECRUITING city: Cairo country: Egypt name: ola mostafa, prof role: CONTACT phone: 01006030036 email: ola.omar@dentistry.cu.edu.eg name: rasha adel, lecture role: CONTACT phone: 01007505888 email: rasha.adel@dentistry.cu.edu.com lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06300762 id: C3079 briefTitle: RCT Exudate Management Cutimed Sorbion Product Range overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2024-12-31 date: 2025-06-30 date: 2024-03-08 date: 2024-03-08 name: BSN Medical GmbH class: INDUSTRY briefSummary: The fluid handling capacity of superabsorbent dressings varies depending on the design and construction. The use of effective advanced wound dressings is a promising strategy to achieve adequate absorption of wound exudate and malodour promoting wound healing. The aim of the current study is to determine whether there is a difference in the clinical performance of exudate absorption with two commonly used CE-marked superabsorbent dressings when used on VLUs in routine wound care.
As primary objective the dressing´s absorption performance and its ability to prevent skin maceration and leakage of the wound dressing will be investigated. conditions: Venous Leg Ulcer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Two assessors are blinded to evaluate some outcomes whoMasked: OUTCOMES_ASSESSOR count: 152 type: ESTIMATED name: Superabsorbent dressing application measure: Exudate management performance measure: Dressing change frequency measure: Moisture-associated skin damages measure: Occurrence clinical relevant peri-wound skin changes measure: Changes in wound tissue and general wound pain measure: Need for debridement after product removal measure: Patient satisfaction with treatment and product measure: HCP satisfaction with treatment and product measure: Changes in quality of life using the "Wound-QoL 14" (short questionnaire measuring quality of life in patients with chronic wounds based on three established disease-specific instruments) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Niels Stensen Klinik, Christliches-Klinikum-Melle city: Melle state: Niedersachsten zip: 49624 country: Germany name: Jan Heggemann role: CONTACT name: Sabine Guth role: CONTACT lat: 52.20197 lon: 8.33826 hasResults: False
nctId: NCT06300749 id: LE-CCM briefTitle: Effectiveness of Chiropractic Cervical Manipulation in Lateral Epicondylitis overallStatus: COMPLETED date: 2018-10-30 date: 2019-01-03 date: 2019-01-03 date: 2024-03-08 date: 2024-03-08 name: Mesut Arslan class: OTHER briefSummary: İt is aimed to examine the effect of chiropractic cervical manipulation on pain, functionality and grip strength in patients with lateral epicondylitis and whether it is preferable to placebo. conditions: Lateral Epicondylitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 50 type: ACTUAL name: Chiropractic Cervical Manipulation name: Sham Technique Practice measure: Numerical Pain Scale (NPS) measure: Grip Strength measure: Patient Rated Tennis Elbow Evaluation (PRTEE) sex: ALL minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT facility: Bitlis Eren University city: Bitlis zip: 13000 country: Turkey lat: 38.40115 lon: 42.10784 hasResults: False
nctId: NCT06300736 id: 2023PI247 briefTitle: Design of a Predictive Score for Contamination of Pediatric Blood Cultures acronym: HEPIC overallStatus: ACTIVE_NOT_RECRUITING date: 2022-01-01 date: 2024-10-01 date: 2024-10-01 date: 2024-03-08 date: 2024-03-08 name: Central Hospital, Nancy, France class: OTHER briefSummary: The contamination rate for blood cultures is high in pediatrics, due to different sampling techniques and the difficulty of sampling small-weight children, thus favoring contamination of the devices at the time of sampling. It is also more difficult to distinguish contamination from true bacteremia in children at an early stage, notably due to the limited number of vials that can be taken at any one time.
Contamination has major consequences for patient management. Studies in adults have shown that contamination increases hospital length of stay by 4 to 5 days, laboratory costs by +20% and recourse to intravenous antibiotic therapy by +39%. In children, studies came to the same conclusion, with greater prescription of antibiotics, particularly intravenous antibiotics, in patients with contaminated blood cultures than in patients with sterile blood cultures. It also showed that 26% of patients with contaminated blood cultures were initially hospitalized because of the positivity of this test.
The aim of this research is to determine the factors associated with contamination, in order to create a predictive score that would help clinicians in their decision-making when receiving the blood culture result as "positive". conditions: Bacteremia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 200 type: ESTIMATED measure: Blood culture diagnosis measure: Score performance sex: ALL maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: CHRU Nancy city: Nancy zip: 54000 country: France lat: 48.68439 lon: 6.18496 hasResults: False
nctId: NCT06300723 id: 2024-BRL-101-SCD-01 briefTitle: Clinical Study of BRL-101 in Severe SCD overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2026-03-20 date: 2026-06-15 date: 2024-03-08 date: 2024-03-22 name: Bioray Laboratories class: INDUSTRY name: First Affiliated Hospital of Guangxi Medical University briefSummary: This is a single center, non-randomized, open label, single-dose study in subjects with Sickle Cell Disease (SCD). The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells (hHSPCs) (BRL-101). conditions: Sickle Cell Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 1 type: ESTIMATED name: BRL-101 measure: Proportion of stem cell engrafted subjects measure: Time to neutrophil engraftment measure: Frequency, severity, and relationship to BRL-101 of adverse events over 12 months following BRL-101 infusion sex: ALL minimumAge: 3 Years maximumAge: 35 Years stdAges: CHILD stdAges: ADULT facility: First Affiliated Hospital of Guangxi Medical University city: Nanning state: Guangxi zip: 530021 country: China name: Yongrong Lai, phD role: CONTACT email: laiyongrong@hotmail.com lat: 22.81667 lon: 108.31667 hasResults: False
nctId: NCT06300710 id: CPR in PICU briefTitle: Outcomes and Risk Factors of CPR in PICU overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-02-01 date: 2025-03-01 date: 2024-03-08 date: 2024-03-18 name: Assiut University class: OTHER briefSummary: 1. To detect the frequency and the underlying causes of cardiopulmonary arrest .
3. To identify the associated risk factors for the different outcomes after CPR among those patients conditions: Cardio Respiratory Arrest studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 30 type: ESTIMATED measure: incidence of cardiac arrest and survival to discharge from the PICU (dead versus alive) measure: Rate of risk factors associated with outcome of CPR sex: ALL minimumAge: 1 Month maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06300697 id: HUM00235532 briefTitle: Michigan Food and Atopic Dermatitis (M-FAD) Program - Molecular Analytics Project overallStatus: RECRUITING date: 2024-02-15 date: 2027-03 date: 2027-03 date: 2024-03-08 date: 2024-04-11 name: University of Michigan class: OTHER briefSummary: This study will explore potential links between atopic dermatitis and food allergy. This information will be useful to determine atopic dermatitis and food allergy share unique biochemical or genetic identifiers useful for diagnosing and treatments in the future.