hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06356805 id: rTMS in Fibromyalgia briefTitle: rTMS Effect on Cognitive and Psychiatric Dysfunction in Patients With Fibromyalgia acronym: rTMS overallStatus: COMPLETED date: 2023-01-10 date: 2024-01-30 date: 2024-02-20 date: 2024-04-10 date: 2024-04-10 name: Assiut University class: OTHER name: Tanta University briefSummary: the aim of this work was to evaluate the effect of low frequency rTMS over the right dorsolateral prefrontal area (DLPFC) on Fibromyalgia patients. Fibromyalgia Impact Questionnaire (FIQ), Hamilton depression and Anxiety scale and different cognitive rating scales were evaluated pre-1 month post sessions and pre -post 3 months later. all eligible patients with fibromyalgia (FM) were randomized to have 20 sessions of active or sham rTMS over right DLPFC. The improvement changes in groups were compared in each rating scale. conditions: Treatment Resistant Disorders studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 42 type: ACTUAL name: repetitive transcranial magnetic stimulation measure: 1- Assessment of Fibromyalgia Impact Questionnaire (FIQ) measure: 1-Assessment of Hamilton depression (HDRS) and Hamilton Anxiety scales (HARS) (pre- post sessions and pre post three months) measure: Assessment of different cognitive rating scales (Montreal cognitive Assessment scale (MoCa), and Rey Auditory Verbal Learning Test [RAVLT], sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Eman Khedr city: Assiut zip: 11517 country: Egypt lat: 27.18096 lon: 31.18368 hasResults: False
nctId: NCT06356792 id: Obstetrics outcome in Abortion briefTitle: Obstetrics , Prenatal Outcomes in Recurrent Miscarriage acronym: OBPORPL overallStatus: RECRUITING date: 2024-04-21 date: 2025-03-21 date: 2025-03-21 date: 2024-04-10 date: 2024-04-10 name: Assiut University class: OTHER briefSummary: The effect of recurrent miscarriage on the outcome of the current pregnancy and if there's a relation between it and adverse out come conditions: Recurrent Miscarriage studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 102 type: ESTIMATED measure: If there's relation between recurrent abortion and having a medical disorder during current pregnancy sex: FEMALE minimumAge: 17 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Assiut University status: RECRUITING city: Assiut country: Egypt lat: 27.18096 lon: 31.18368 hasResults: False
nctId: NCT06356779 id: H-23066725 briefTitle: Longitudinal Study of Local Ablative Therapy in Oligometastatic Disease acronym: OLIGO-DK overallStatus: RECRUITING date: 2024-04-15 date: 2030-12-31 date: 2035-12-31 date: 2024-04-10 date: 2024-04-16 name: Gitte Fredberg Persson MD PhD class: OTHER briefSummary: This prospective national multicenter observational and interventional study aims to assess the longitudinal disease trajectory of patients with oligometastatic disease (OMD) who receive local metastasis-directed therapy. Patients with any category of OMD from any non-hematological cancer are eligible for inclusion. Local ablative therapy (LAT) includes surgical metastasectomy, radiotherapy, thermal ablation, and electroporations.
nctId: NCT06356766 id: 30.01.2024/009 briefTitle: Investigation of Effectiveness of Telerehabilitation for Zone 2 Flexor Tendon Injuries of the Hand overallStatus: NOT_YET_RECRUITING date: 2024-04-08 date: 2024-10-08 date: 2025-04-08 date: 2024-04-10 date: 2024-04-16 name: Istanbul University class: OTHER briefSummary: The treatment process following Zone 2 flexor tendon injuries, which are particularly controversial for hand surgery, is challenging. There are various rehabilitation methods for Zone 2 flexor tendon injuries, one of which is the Modified Duran Protocol. Disruptions in the physiotherapy process lead to joint contractures, tendon adhesions, and limitations in daily life activities for patients. Due to global issues such as socioeconomic factors, physical barriers, distance, and pandemics, patients who cannot actively participate in physiotherapy miss out on the rehabilitation process.
The aim of the present study is to investigate the effectiveness of the Modified Duran protocol applied through telerehabilitation following Zone 2 flexor tendon repair. Between April and October 2024, a total of 42 adults aged 18-55 who underwent Zone 2 flexor tendon repair at Istanbul University Istanbul Faculty of Medicine will be recruited, with 21 participants in face-to-face clinic group and 21 in telerehabilitation group. Rehabilitation process will be followed for 12 weeks. The telerehabilitation group will receive exercise training on the third day. After the first training session, patients will be discharged and called to the clinic once a week for dressing changes, monitoring, exercises and if necessary, revision of the protective splint. Patients will be contacted three times a week to implement the planned program using telerehabilitation.
SPSS (Statistical Package for the Social Sciences) Statistics will be used for the statistical analysis of all data, with a significance level of p \<0.05 considered significant in all assessments, and accepted as two-tailed. conditions: Zone 2 Flexor Tendon Injuries of the Hand studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 42 type: ESTIMATED name: Telerehabilitation name: Face-to-face rehabilitation measure: Range of Motion measure: DASH measure: Pain of the affected hand measure: Muscle Strength sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT hasResults: False
nctId: NCT06356753 id: RC19_0203 briefTitle: EndoxOmics : Exposome, Endometriosis and Fertility acronym: EndoxOmics overallStatus: COMPLETED date: 2019-09-01 date: 2021-03-31 date: 2021-03-31 date: 2024-04-10 date: 2024-04-10 name: Nantes University Hospital class: OTHER briefSummary: For several years, the effects of environmental pollution on human health have been a growing concern for the scientific community and public authorities. Among the many known chemical contaminants, persistent organic pollutants (POPs) are of particular concern because of their properties as endocrine disrupters, bioaccumulation and biomagnification. The associations between environmental pollutants, endometriosis and infertility remains poorly understood. The objective of this exploratory non interventional monocentric study conducted in the University Hospital of Nantes, is to identify endogenous molecular profiles associated with endometriosis and related infertility. This project implements an exploratory approach combining exposure and metabolomics approaches based on high-resolution mass spectrometry to identify exposure and metabolomics profiles associated with infertility, and biomarkers for potential prognostic application. conditions: Endometriosis conditions: Infertility, Female studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 87 type: ACTUAL measure: Identify endogenous molecular profiles of patients with infertile endometriosis measure: Characterize the internal chemical exposure profiles and metabolomic profiles in the different groups. measure: Compare the distribution of contaminant concentration levels and metabolomic profiles according to the media measured. sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Nantes University Hospital city: Nantes state: Loire-Atlantique zip: 44093 country: France lat: 47.21725 lon: -1.55336 hasResults: False
nctId: NCT06356740 id: 69HCL22_0878 id: 2023-508611-22-00 type: CTIS briefTitle: Efficacy and Tolerance of Abacavir/Lamivudine Treatment in Patients With Systemic Lupus Erythematosus acronym: PENCIL overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2028-11-01 date: 2029-06-01 date: 2024-04-10 date: 2024-04-10 name: Hospices Civils de Lyon class: OTHER briefSummary: Systemic lupus (SL) is a rare chronic autoimmune disease characterized by the production of autoantibodies directed against nuclear antigens, particularly native double-stranded deoxyribonucleic acid (DNA), and excessive production of antiviral cytokines: type I interferons, particularly interferon alpha (IFN-α). IFN-α production results from the excessive detection of nucleic acids (DNA or Ribonucleic Acid (RNA)) by endosomal or intracytoplasmic receptors that are capable of inducing interferon production. The precise mechanisms of cytoplasmic sensor activation remain unknown; however, recent work in the field of interferonopathies suggests a role for human endogenous retroviruses (HERVs). HERVs are remnants of ancient infections caused by exogenous retroviruses integrated into the genome during evolution and represent 8% of the human genome.Several studies have suggested a role for HERVs in the development and maintenance of an excessive immune response in lupus patients and other autoimmune diseases by affecting the type I interferons (I IFN) signalling pathway.
In this study, an innovative therapeutic strategy using a combination of nucleoside reverse transcriptase inhibitors (NRTIs), abacavir/lamivudine, is proposed to treat SLE. Thus, we propose a pilot Phase II, randomized, open-label study using NRTIs in patients with SL in remission or with low clinical activity, and evaluating a biological endpoint (IFN signature), which is a direct proxy for the drug's expected effect.
nctId: NCT06356714 id: 13914704179 briefTitle: Nocardia Rubra Cell Wall Skeleton in Combination With Prior Second- or Third-line Regimens for the Treatment of Potentially Hazardous Colorectal Cancer SD Status overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-08-01 date: 2024-04-10 date: 2024-04-10 name: Sun Jing class: OTHER briefSummary: Evaluate the efficacy and safety of Nocardia rubra cell wall skeleton in combination with prior second- or third-line regimens for the treatment of potentially hazardous colorectal cancer SD(Stable Disease) status in the real world. conditions: Colorectal Cancer conditions: Colorectal Neoplasms studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 22 type: ESTIMATED name: Nocardia Rubra Cell Wall Skeleton in Combination With Prior Second- or Third-line Regimens measure: Progression-free survival(PFS) measure: Overall survival (OS) measure: Objective remission rate (ORR) measure: Disease Control Rate (DCR) measure: Incidence and extent of major security incidents measure: Quality of Life Score (QoL) for tumor patients sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06356701 id: dongyandl briefTitle: Tumor Nutritional Therapy in the First-line Treatment of Stage IV NSCLC overallStatus: RECRUITING date: 2024-04-15 date: 2024-12-31 date: 2025-12-31 date: 2024-04-10 date: 2024-04-10 name: The First Affiliated Hospital of Dalian Medical University class: OTHER briefSummary: A Single-center, Randomized, Controlled Clinical Study Comparing the Efficacy and Safety of Tumor Nutritional Therapy Combined With Immune Checkpoint Inhibitors and Chemotherapy in the First-line Treatment of Stage IV NSCLC Without Driver Gene Mutations conditions: Long-Term Effects Secondary to Cancer Therapy studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 120 type: ESTIMATED name: Cancer nutritional treatment regimen (Spirulina Bifidobacterium Capsules, Fish Oil Grape Seed Blueberry Soft Capsules, Ganoderma Spore Oil Soft Capsules) measure: PFS measure: Assessment of global disorders in patients with cancer measure: ORR sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: DongYan status: RECRUITING city: Dalian City state: Liaoning zip: 116000 country: China name: DongYan Dong role: CONTACT phone: 18098876750 email: dongyan979828@hotmail.com hasResults: False
nctId: NCT06356688 id: 13914704178 briefTitle: A Clinical Study on the Efficacy and Safety of Paclitaxel Polymer Micelles and Cisplatin Combined With Cadonilimab as a Neoadjuvant Therapy for Locally Advanced Esophageal Squamous Cell Carcinoma overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2025-04-20 date: 2025-06-20 date: 2024-04-10 date: 2024-04-10 name: Sun Jing class: OTHER briefSummary: The purpose of this study is to investigate the efficacy and safety of neoadjuvant treatment of locally advanced esophageal squamous carcinoma with a PD-1/CTLA-4 bispecific antibody (cadonilimab) in combination with platinum-containing chemotherapy (paclitaxel polymer micelles combined with cisplatin). Includes pathologic complete remission rates (pCR rates) after 2-4 cycles of cadonilimab combination chemotherapy. The objective remission rate (ORR), major pathologic remission rate (MPR), R0 resection rate and 2-year overall survival (OS) and progression-free survival (OS) rates, and safety of neoadjuvant treatment of locally advanced esophageal squamous carcinoma with cadonilimab combined with chemotherapy. conditions: Locally Advanced Esophageal Squamous Cell Carcinoma conditions: Neoadjuvant Therapy studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: paclitaxel polymer micelles and cisplatin combined with Camrelizumab primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: paclitaxel polymer micelles and cisplatin combined with Cadonilimab measure: Pathological complete response (pCR) rates measure: Objective Rate of Effectiveness (ORR) measure: R0 Removal Rate measure: 2-year overall survival rate measure: 2-year disease free survival rate measure: major pathological response (MPR) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06356675 id: A single-arm pilot briefTitle: A Single-arm Pilot Study of Tislelizumab Combined With Anlotinib in Patients With Advanced NSCLC With Driver-negative After Progression to Immunotherapy overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2028-07-01 date: 2028-07-01 date: 2024-04-10 date: 2024-04-10 name: The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine class: OTHER briefSummary: Immune resistance after treatment, there is no standard treatment, one of the most important and the most effective measures is immune to combination therapy。Targeted angiogenesis therapy has always been the focus of research on the treatment of NSCLC patients with progressive disease after immunotherapy. From the mechanism of action, angiogenesis and immunosuppression are interrelated processes. conditions: Advanced NSCLC studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 33 type: ESTIMATED name: Tislelizumab name: Anlotinib measure: objective response rate measure: progression free survival time measure: over survival time measure: disease control rate measure: safety including any grade adverse events sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06356662 id: KY-2023-198 briefTitle: Tenofovir Disoproxil Fumarate in the Treatment of Parkinson's Disease overallStatus: RECRUITING date: 2024-01-23 date: 2024-08-31 date: 2024-12-31 date: 2024-04-10 date: 2024-04-10 name: The Fourth Affiliated Hospital of Zhejiang University School of Medicine class: OTHER briefSummary: To evaluate the efficacy and safety of tenofovir disoproxil fumarate in the treatment of Parkinson's disease. The changes of motor symptoms and the occurrence of adverse reactions in early Parkinson's disease patients who took tenofovir disoproxil fumarate and did not take Tenofovir disoproxil fumarate at different time points were compared. conditions: Parkinson Disease studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Tenofovir Disoproxil Fumarate measure: UPDRS III（Unified Parkinson's Disease Rating Scale part 3） measure: Non-Motor Symptom Scale（NMSS） measure: creatinine(μmoI/L) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Guohua Zhao status: RECRUITING city: Hangzhou state: Zhejiang country: China name: Zhao Guohua, Doctor role: CONTACT phone: +86 13777812308 email: gzhao@zju.edu.cn lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06356649 id: ESOGU2 briefTitle: Investigation of the Effects of Pressure Support Ventilation and Positive Airway Pressure Modes During Extubation overallStatus: COMPLETED date: 2023-03-15 date: 2024-01-15 date: 2024-01-20 date: 2024-04-10 date: 2024-04-10 name: Eskisehir Osmangazi University class: OTHER briefSummary: Controlled ventilation is applied to patients intubated for general anesthesia. Additionally, positive end-expiratory pressure (PEEP) and pressure support are mechanical ventilation modes that have been used in general anesthesia practice for many years. When the recovery-extubation phase is reached, intermittent bag-mask ventilation is usually used and the patient is allowed to breathe spontaneously and is extubated when an adequate respiratory level is reached. It has been shown in previous studies that the use of intermittent mask ventilation causes postoperative atelectasis. Different methods have been used to prevent postoperative atelectasis. In our study, we aimed to observe the effect of terminating general anesthesia at the end of the operation and using PEEP and pressure-supported ventilation during the extubation phase on early complications. conditions: Anesthesia studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 199 type: ACTUAL name: extubation measure: Complications developing during recovery-extubation measure: hemodynamic changes measure: hemodynamic data sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Eskisehir Osmangazi University Medical Faculty city: Eskisehir state: Odunpazarı zip: 26040 country: Turkey lat: 39.77667 lon: 30.52056 hasResults: False
nctId: NCT06356636 id: P1216/2022 briefTitle: Impact of the Financial Inclusion Improves Sanitation and Health acronym: FINISH overallStatus: RECRUITING date: 2022-01-01 date: 2025-12-31 date: 2025-12-31 date: 2024-04-10 date: 2024-04-10 name: Amref Health Africa class: OTHER briefSummary: The goal of this interventional study is to evaluate the impacts of Financial Inclusion improvement sanitation and Health (FINISH) interventions in Kenya's Homa Bay County and Uganda's Kamwenge District among children under five. The main questions it aims to answer are:
Researchers will then compare intervention areas (Homa Bay in Kenya and Kamwenge in Uganda) with control areas (Siaya and Bushenyi in Kenya and Uganda, respectively) to see if the FINISH intervention leads to improved sanitation, health outcomes, and economic benefits. conditions: Health Knowledge, Attitudes, Practice studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The participants are divided into two or more groups, with each group receiving a different intervention or a control condition. The outcomes of each group are compared at the end of the study to assess the effectiveness of the intervention. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: QUADRUPLE maskingDescription: to be updated whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 1090 type: ESTIMATED name: Financial Inclusion Improves Sanitation and Health measure: Health outcome, measured as, Proportion of households with diarrhoea occurrence in children under five years, and social outcome measured as proportion of households whose children missed school due to diarrhoea occurrence sex: ALL minimumAge: 0 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Homa Bay county status: RECRUITING city: Homa Bay country: Kenya name: Martin Dr Muchangi, PhD role: CONTACT phone: 0721453712 email: martin.muchangi@amref.org lat: -0.52731 lon: 34.45714 hasResults: False
nctId: NCT06356623 id: SHDC2202020401 briefTitle: A Risk Prediction Model of Postoperative Nausea and Vomiting in Patients With Liver Cancer overallStatus: NOT_YET_RECRUITING date: 2024-05-05 date: 2024-08-05 date: 2024-08-06 date: 2024-04-10 date: 2024-04-10 name: Shanghai Zhongshan Hospital class: OTHER briefSummary: PONV management has been recommended as a necessary part of enhanced recovery protocols during the perioperative period, and PONV risk assessment is, therefore, a necessary first step in determining the number of medications or strategies for prophylaxis and treatment by considering the number of modifiable and non-modifiable risk factors. However, the external validity of two commonly-used PONV prediction models for patients undergoing liver surgery is unsatisfied, and need to be updated for liver cancer populations to better inform personalized perioperative care regime and individualized decision-making in clinical practice. conditions: Nausea and Vomiting, Postoperative conditions: Liver Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 476 type: ESTIMATED name: 1 measure: Postoperative nausea and vomiting sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06356597 id: KY2024-004-A briefTitle: Tislelizumab With Fruquintinib, Metronidazole, in Mismatch Repair-proficient or Microsatellite Stability, Advanced Colorectal Cancer: a Multicenter, Single Arm, Clinical Trial overallStatus: RECRUITING date: 2024-04-01 date: 2025-12-12 date: 2027-12-12 date: 2024-04-10 date: 2024-04-10 name: Jing-yuan Fang, MD, Ph. D class: OTHER briefSummary: The aim of this study is to evaluate the efficacy and safety of Tislelizumab with Fruquintinib, Metronidazole treatment in MSS/MSI-L advanced colorectal cancer patients with high abundance of Fusobacterium nucleatum in a single arm Phase II clinical. conditions: Colorectal Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 25 type: ESTIMATED name: Tislelizumab with Fruquintinib, Metronidazole measure: objective response rate sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai First People's Hospital status: RECRUITING city: Shanghai country: China name: Qi Li role: CONTACT lat: 31.22222 lon: 121.45806 facility: Shanghai Ninth People's Hospital status: NOT_YET_RECRUITING city: Shanghai country: China name: Yanjie Zhang role: CONTACT lat: 31.22222 lon: 121.45806 hasResults: False