hackint0sh/New-Dataset huggingface dataset:
Participants will be assessed at the beginning of the study (baseline) and after 30 days (clinical examination) and 60 days (clinical examination, assessment of Peripheral neuropathy, assessment of peripheral artery disease, blood and urine tests, and quality of life evaluation). primaryPurpose: PREVENTION masking: TRIPLE maskingDescription: * 1 physician-researcher who will conduct all initial evaluations and follow-up examinations (excluding Doppler ultrasound, Ankle-Brachial Index - ABI, and Toe-Brachial Index - TBI), without knowledge of the subjects' allocation, and will administer the Informed Consent Form (ICF).
* 2 physician residents who will provide daily contact for device usage control, guidance, addressing inquiries, etc. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 64 type: ESTIMATED name: Photobiomodulation name: Simulation of Photobiomodulation name: Therapeutic education measure: Ulcer Incidence measure: Ulcer Incidence measure: Ulcer Incidence measure: Tactile sensitivity with Semmes-Weinstein monofilament measure: Tactile sensitivity with Semmes-Weinstein monofilament measure: Vibratory sensitivity measure: Vibratory sensitivity measure: Assessment of Achilles reflex measure: Assessment of Achilles reflex measure: Neuropathy Symptom Score (NSS) measure: Neuropathy Symptom Score (NSS) measure: Neuropathic Impairment Score (NIS) measure: Neuropathic Impairment Score (NIS) measure: Evaluation of the degree of ischemia measure: Evaluation of the degree of ischemia measure: Systolic peak velocity measure: Systolic peak velocity measure: Resistance Index measure: Resistance Index measure: Waveform pattern measure: Waveform pattern measure: Evaluation of claudication measure: Evaluation of claudication measure: Thermography measure: Thermography measure: Quality of Life Assessment measure: Quality of Life Assessment sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06353555 id: PUMCH-20240311 briefTitle: Efficacy of Thyroid Hormone Replacement for Secondary Hypothyroidism Following Intracerebral Hemorrhage overallStatus: RECRUITING date: 2023-10-11 date: 2025-06-01 date: 2025-12-31 date: 2024-04-09 date: 2024-04-09 name: Peking Union Medical College Hospital class: OTHER briefSummary: Low levels of serum triiodothyronine (T3) thyroid hormones (T4) are a strong predictor of mortality and poor prognosis in critical care patients. Few reports, however, have focused on neurocritical patients.
Patients with severe neurological diseases often experience more complications and exhibit higher mortality rates, and many studies have provided evidence for a low T3/T4 state being an important prognostic indicator in such cases; Lieberman et al. found that 87% of individuals with severe traumatic brain injury have thyroid function below the mid-normal range. Other researchers showed that low T3 syndrome is a predictor of poor prognosis in cerebral infarction patients; their findings indicated the central hypothyroidism and disturbance of thyroid hormone metabolism were involved. Low T3 syndrome is common in patients with brain tumors and has been shown to be associated with shorter survival in glioma patients. Despite these observations, however, whether the thyroid hormone abnormalities in the critically ill are a physiological adaptation or a pathological change, and whether hormone replacement therapy (HRT) can benefit such patients, remain to be established.
As acute progression ceases, thyroid hormone levels may return to normal. This may imply that thyroid hormone supplements could improve the prognosis of patients with secondary hypothyroidism. Previous clinical studies have examined the effect of thyroid HRT on patients undergoing cardiac surgery; patients with malnutrition, heart failure, or acute renal failure; and premature infants with acute respiratory distress syndrome. Most of these past studies found no significant positive effects on prognosis, and no harmful effects either. Some smaller studies have demonstrated potential promise for the use of HRT; for example, one study showed that T3 supplementation in patients undergoing cardiac surgery could lead to less need for inotropic support and better hemodynamic parameters. There are no reports of thyroid HRT improving the prognosis of neurocritical patients with secondary hypothyroidism.
This study aims to explore the safety and effectiveness of thyroid hormone replacement therapy in patients with spontaneous intracerebral hemorrhage and concomitant secondary hypothyroidism. conditions: Intracerebral Hemorrhage conditions: Low T3 Syndrome conditions: Neurocritical Care conditions: Hormone Replacement Therapy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 100 type: ESTIMATED name: Euthyrox name: Euthyrox measure: blood pressure measure: cerebral blood flow dynamics measure: Whether to use vasoactive vasopressors measure: neurological function measure: Days of the patients received intensive care measure: Mechanical ventilation time sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking union medical college hospital status: RECRUITING city: Beijing state: Beijing zip: 100730 country: China name: Junji Wei role: CONTACT phone: +8615801056698 email: weijunji@pumch.cn lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06353542 id: HCB/2023/1206 id: PI23/01856 type: OTHER domain: Institut d'Investigacions Biomèdiques August Pi i Sunyer briefTitle: Barcelona Esquerra Glaucoma Artificial Intelligence-based Screening Program (BEGAS) acronym: BEGAS overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2026-03 date: 2026-09 date: 2024-04-09 date: 2024-04-09 name: Hospital Clinic of Barcelona class: OTHER briefSummary: Two primary care-based screening systems will be tested to identify subjects with referrable glaucoma to hospital care.
Secondary analyses will include potential diagnostic composite scores (including other ancillary tests, such as optical coherence tomography images, that could maximize the screening process); the identification of population and disease characteristics (type of glaucoma, intraocular pressure) that could increase the effectivity and adherence to the screening process. conditions: Glaucoma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: DOUBLE whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 500 type: ESTIMATED name: Software analysis name: Ophthalmologist examination measure: Diagnostic agreement between the AI software and the ophthalmic examination measure: Health-Related Quality of Life (HRQoL) measure: Demographics measure: Intraocular pressure measure: Optical coherence tomography (OCT) measure: Visual field measure: Cost-effective analysis of both screening methods measure: Risk score with parameters associated with positive screening of glaucoma sex: ALL minimumAge: 40 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Clínic - ICOF city: Barcelona zip: 08028 country: Spain name: Nestor Ventura Abreu, MD, PhD role: CONTACT phone: +34932275400 phoneExt: 9336 email: neventura@clinic.cat name: Marta Pazos, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 41.38879 lon: 2.15899 hasResults: False
nctId: NCT06353529 id: 17065 briefTitle: Sphenopalatine Ganglion Block for Postop Pain Management acronym: SPGB overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-05 date: 2024-04-09 date: 2024-04-09 name: Hamilton Health Sciences Corporation class: OTHER briefSummary: To assess the benefit of using an additional nerve block during minimally invasive pituitary surgery, to improve pain management after surgery. The medication (Bupivacaine) or a placebo (saline) will be injected during surgery and patients will be asked about their level of pain at multiple time points in the first 24 hours following surgery. The aim is to improve patient outcomes and reduce the need for pain medication after surgery. conditions: Pituitary conditions: Pain, Postoperative studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 52 type: ESTIMATED name: Bupivacaine-Epinephrine 0.5%-1:200,000 Injectable Solution name: Placebo measure: Post-operative pain score measure: Post-operative bleeding measure: Post-operative complications measure: Analgesic requirement measure: Length of stay sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hamilton General Hospital city: Hamilton state: Ontario zip: L8L 2X2 country: Canada name: Dr. Kesava Reddy, MD role: CONTACT phone: 905-521-2100 email: reddy@hhsc.ca name: Ms. Jessy Moore, MSc role: CONTACT phone: 289-686-8827 email: moorej@hhsc.ca lat: 43.25011 lon: -79.84963 hasResults: False
nctId: NCT06353516 id: 2310-117-126 briefTitle: The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients overallStatus: RECRUITING date: 2024-02-14 date: 2024-09 date: 2024-12 date: 2024-04-09 date: 2024-04-09 name: Chung-Ang University Gwangmyeong Hospital class: OTHER name: National Research Foundation of Korea briefSummary: The goal of this clinical trial is to compare the permeability of blood-brain barrier between the intravenous anesthesia group and the inhalation gas anesthesia group in the elderly patients undergoing surgery. The main questions it aims to answer are:
* Inhalation gas anesthetics conditions: Postoperative Cognitive Dysfunction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The participants are randomly assigned to total intravenous anesthesia group or inhaled gas anesthesia group primaryPurpose: PREVENTION masking: TRIPLE maskingDescription: This study is a double-blinded randomized controlled trial. The group assignment is conducted by the pre-generated random number table. The participant, investigator and the outcome assessor are blinded to the group assignment. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 154 type: ESTIMATED name: Propofol name: Sevoflurane measure: Concentration of serum S100B levels measure: Incidence of Delirium measure: Incidence of Postoperative Cognitive Dysfunction measure: Concentration of serum albumin measure: Concentration of serum CRP measure: Concentration of serum IL6 levels measure: Concentration of serum TNFα levels measure: Concentration of cerebrospinal fluid (CSF) albumin sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chung-Ang University Gwangmyeong Hospital status: RECRUITING city: Gwangmyeong state: Gyeonggi-do zip: 14353 country: Korea, Republic of name: Wongook Wi, M.D. role: CONTACT phone: 02-2222-1553 email: hestia.w@gmail.com hasResults: False
nctId: NCT06353503 id: KAZ briefTitle: Bone Marrow Aspirate Concentrate for Anterior Cruciate Ligament Tear Treatment. overallStatus: RECRUITING date: 2024-04-02 date: 2024-09-27 date: 2024-09-27 date: 2024-04-09 date: 2024-04-09 name: abdulmajeed hammadi class: INDUSTRY briefSummary: A single armed multicenter study enrolling 20 patients using autologous bone marrow aspirate concentrate (which is done under local or general anesthesia to aspirate around 1-2 cc/kg body weight then concentration which is done by using centrifugation and special disposable kit) local injection of 4 cc per joint under ultrasonic guidance ,completely sterile field with local anesthesia. conditions: Anterior Cruciate Ligament Tear studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: single armed study open label primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: autologous bone marrow aspirate concentrate measure: Functional recovery by clinical assessments of the ACL and overall knee joint stability. measure: magnetic resonance imaging of the knee joint sex: ALL minimumAge: 20 Years maximumAge: 55 Years stdAges: ADULT facility: Ministry of Health status: RECRUITING city: Baghdad zip: 964 country: Iraq name: thamer A alrubaie, MD role: CONTACT phone: +9647700009294 email: alzaitounhospital@gmail.com lat: 33.34058 lon: 44.40088 hasResults: False
nctId: NCT06353490 id: Geon-111001 briefTitle: The Clinical Performance Validation of Electronic Thermometer and Infrared Thermometers overallStatus: ACTIVE_NOT_RECRUITING date: 2022-08-12 date: 2023-11-08 date: 2024-08-11 date: 2024-04-09 date: 2024-04-09 name: Geon Corporation class: INDUSTRY briefSummary: Geon Corporation develops ear thermometers and forehead thermometers that use infrared measurement technology to measure human body temperature. This study verify the accuracy and repeatability of investigational devices. Efficacy verification is carried out by comparing with the referent medical devices.
2. To verify the consistency of repeated measurements of investigational devices. conditions: Febrile conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 150 type: ACTUAL name: Infrared Forehead Thermometer (GE-TF03) name: Infrared Ear Thermometer (GE-TE06) name: Electronic Thermometer (MT-B321FB) name: Electronic Thermometer (MT-B231) measure: Clinical Bias measure: Limits of Agreement measure: Clinical Repeatability sex: ALL maximumAge: 80 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Hsinchu MacKay Memorial Hospital city: Hsinchu country: Taiwan lat: 24.80361 lon: 120.96861 facility: HsinChu Municipal MacKay Memorial Hospital city: Hsinchu country: Taiwan lat: 24.80361 lon: 120.96861 hasResults: False
nctId: NCT06353477 id: EOU 2019-10 briefTitle: Hand, Foot, and Mouth Disease: Could EPs®7630 be a Treatment Option overallStatus: COMPLETED date: 2019-06-01 date: 2022-06-01 date: 2023-01-01 date: 2024-04-09 date: 2024-04-09 name: Eskisehir Osmangazi University class: OTHER name: Abdi Ibrahim Ilac San. ve Tic A.S. briefSummary: This randomized controlled study aims to evaluate the effectiveness and safety of the pharmaceutical extract EPs® 7630 from P.sidoides in treating hand, foot, and mouth disease in children. The study will investigate the impact of EPs® 7630 on the severity of the disease over a specific period and its effects on hospitalization rates and potential complications. This research aims to contribute to the treatment of hand, foot, and mouth disease in children. conditions: Hand, Foot, and Mouth Disease studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: EPs® 7630 is an extract from the roots of Pelargonium sidoides, drug-extract ratio 1 : 8-10, extraction solvent ethanol 11% (w/w). The patients were divided into two groups: (i) group 1 received herbal drug EPs® 7630 by oral route \[Umca® solution; (3x10 drops; between 1-5 years of age, 3x20 drops; 6-12 years of age, 3x30 drops for children \>12 years of age)\] for 7 days and (ii) group 2 (control group) did not receive any herbal medication. The medication was administered orally, at least 30 minutes before or after meals. Patients in both groups were prescribed paracetamol (10 mg/kg/dose, 4 times a day, maximum 4,000 mg/day.) as an antipyretic agent. Temperature measurement was made at home and in the hospital via the axillary route. primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 240 type: ACTUAL name: EPs® 7630 measure: the patient's fever status, restlessness, inappetence, and sleeplessness scores sex: ALL minimumAge: 1 Year maximumAge: 10 Years stdAges: CHILD facility: Istinye University Medicine Faculty Hospital city: Esenyurt state: İstanbul zip: 34517 country: Turkey lat: 41.02697 lon: 28.67732 hasResults: False
nctId: NCT06353464 id: 2306009984 briefTitle: A Translational Understanding of Obesity-Related Phenotypes Using Brain Imaging and Manipulation acronym: OPBIM overallStatus: RECRUITING date: 2023-10-04 date: 2025-09 date: 2025-09 date: 2024-04-09 date: 2024-04-09 name: Drexel University class: OTHER briefSummary: This study will examine a potential relationship between family history of obesity, that is whether people with at least one parent who had obesity in adulthood compared to people with two parents who did not have obesity in adulthood, and the ability of protein intake to curb further intake of food. conditions: Obesity studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: individuals consume two distinct preloads at separate sessions primaryPurpose: BASIC_SCIENCE masking: NONE maskingDescription: Participants consume two preloads one at each visit, but are not informed which preload is being consumed on which test visit. count: 80 type: ESTIMATED name: Ensure and Water measure: Grams of pizza consumed measure: Baseline medial prefrontal cortex oxygenated hemoglobin measure: Baseline lateral prefrontal cortex oxygenated hemoglobin measure: medial prefrontal cortex Oxygenated hemoglobin concentration measure: lateral prefrontal cortex Oxygenated hemoglobin concentration measure: medial prefrontal cortex Time to Peak Light Intensity measure: lateral prefrontal cortex Time to Peak Light Intensity measure: Preload Oxygenated Hemoglobin Difference sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Drexel University status: RECRUITING city: Philadelphia state: Pennsylvania zip: 19104 country: United States name: Principal Investigator, PhD RD role: CONTACT phone: 267-359-6287 email: foodbrainstudies@drexel.edu lat: 39.95233 lon: -75.16379 hasResults: False
nctId: NCT06353451 id: EK GZ 67/2021-2024 briefTitle: Digital Detox Study: A Randomized Controlled Trial overallStatus: COMPLETED date: 2023-10-23 date: 2024-01-21 date: 2024-01-21 date: 2024-04-09 date: 2024-04-09 name: Danube University Krems class: OTHER briefSummary: The aim of the present RCT is to investigate the effect of smartphone screen time reduction on mental health indicators in healthy, 18-29 yo Austrian students.
After inclusion and randomization to intervention- and control group, normal screen time behavior will be assessed for 10-days. After that, the mental health parameters will be carried out in both groups as a baseline survey (T0). After that, intervention group should limit smartphone screen time to less than 2 hours per day for three consecutive weeks. Control group should use smartphones as usual. After that, mental health parameters will be assessed again in both groups (post-intervention, T1). After T1, there are no further requirements regarding screen time. Mental health parameters will be assessed again in both groups at follow-up (T2).
The primary hypothesis (stated at Open Science Framework before Enrollment: https://osf.io/a9k76) is that mental health indicators, particularly stress, depressive symptoms, and sleep quality will improve throughout the intervention compared to the control group as well as to baseline. conditions: Health Behavior studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two groups, non blinded, randomized controlled trial primaryPurpose: PREVENTION masking: NONE count: 111 type: ACTUAL name: Digital Detox measure: Depressive Symptoms measure: Stress measure: Sleep Quality measure: Well-being measure: Problematic smartphone use measure: Body Appreciation measure: Anxiety Symptoms measure: Eating Disorder measure: Physical Activity measure: Heart rate variability (HRV) measure: Resting Heart Rate (RHR) measure: Screen time sex: ALL minimumAge: 18 Years maximumAge: 29 Years stdAges: ADULT facility: Danube University Krems city: Krems state: Lower Austria zip: 3500 country: Austria lat: 48.40921 lon: 15.61415 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-11-08 uploadDate: 2024-03-26T06:01 filename: Prot_SAP_000.pdf size: 251127 hasResults: False
nctId: NCT06353438 id: 2024XXXX briefTitle: Hydraulic Resistance and Older Adults overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-07-31 date: 2024-12-31 date: 2024-04-09 date: 2024-04-09 name: College of Staten Island, the City University of New York class: OTHER name: Bay Ridge Center briefSummary: The goal of this quasi-experimental study using a pre and post test design is to learn about the effect of participating in an exercise program with hydraulic exercise equipment on fall risk in the older adult population. The main questions it aims to answer are:
Participants will be evaluated pre and post intervention for strength, fall risk using Berg Balance Scale, Tinetti Balance and Gait Assessment, Timed Up and Go, and functional ability using the Lower Extremity Functional Scale. Participants will engage in an exercise program using 5 different pieces of hydraulic exercise equipment (Frei FACTUM® novus II line) 2x/week for for 6 weeks for 30-45 minutes each session. The equipment uses concentric movements only and works agonist and antagonist muscles with each machine (IE: push and pull, both concentric). conditions: Aging conditions: Fall conditions: Old Age; Debility conditions: Muscle Weakness studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 20 type: ESTIMATED name: Exercise Program measure: Berg Balance Scale measure: Timed Up and Go measure: Tinetti Balance and Gait Assessment Tool measure: Lower Extremity Functional Scale measure: Strength sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bay Ridge Center city: Brooklyn state: New York zip: 11209 country: United States name: Mary Ann Coughlin role: CONTACT phone: 718-306-2924 email: mcoughlin@bayridgecenter.org lat: 40.6501 lon: -73.94958 hasResults: False
nctId: NCT06353425 id: 0562/66 briefTitle: Multi-country Survey on Violence Against Women Among Women overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-03 date: 2025-03 date: 2024-04-09 date: 2024-04-09 name: Chulalongkorn University class: OTHER name: Asia and Oceania Federation of Obstetrics and Gynaecology briefSummary: The goal of this observational study is to explore and learn about violence against women (VAW) among reproductive-aged women in Asia and Oceania countries. The main questions it aims to answer are:
Participants will be ever-partnered women aged 15-49 years. The definition of "ever-partnered women" included women who have current and former husbands; current and former cohabiting; or non-cohabiting male intimate partners. conditions: Violence Against Women studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 2000 type: ESTIMATED measure: prevalence of violence against women measure: KAP towards violence against women measure: need of support services for violence against women sex: FEMALE minimumAge: 15 Years maximumAge: 49 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06353412 id: treatment methods of IIH briefTitle: Current Treatment Methods of Idiopathic Intracranial Hypertension overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-09-01 date: 2026-03-09 date: 2024-04-09 date: 2024-04-09 name: Assiut University class: OTHER briefSummary: Aim of the study :
3. to determine complication of each type of treatment method conditions: IIH - Idiopathic Intracranial Hypertension studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 64 type: ESTIMATED name: Lumbar puncture measure: Patient improvement regarding headache, visual symptoms measure: Patients improvement regarding fundus examination during regular visual assessment measure: Complication measure: Other sex: ALL minimumAge: 16 Years maximumAge: 75 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False