The main hypothesis of this study is that in patients with PE at intermediate risk of recurrence, RPVO computed with V/Q SPECT/CT imaging may be an important predictor of recurrence. conditions: Pulmonary Embolism conditions: Venous Thromboembolism studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Cohort study primaryPurpose: PREVENTION masking: NONE count: 665 type: ESTIMATED name: Ventilation/Perfusion Single Photon Emission Computed Tomography (V/Q SPECT/CT) measure: Symptomatic recurrent venous thromboembolism (VTE), including objectively confirmed nonfatal symptomatic PE or proximal deep vein thrombosis or fatal PE during a 24-month follow-up after inclusion in the study measure: Adjudicated symptomatic objectively confirmed recurrent VTE during the follow-up period. measure: Percentage of patients with RPVO (as defined by a perfusion defect > 5%) on V/Q SPECT/CT imaging at inclusion in the study. measure: Different cut-offs of pulmonary vascular obstruction index will be evaluated to predict the risk of VTE recurrence at 2 years, by generating ROC curves measure: Other predictors of adjudicated symptomatic objectively confirmed recurrent VTE at 2 years including: age measure: The following score will be computed : HERDOO2 (Hyperpigmentation, Edema, Redness, D-Dimer, Obesity, Old) measure: Potential predictors of RPVO including : demographics measure: Symptomatic recurrent VTE during a 3 Months follow-up period in patients with suspicion of PE recurrence who has been left untreated based on a negative V/Q SPECT/CT scan measure: Dyspnea index will be assessed using mMRC scale (Modified Medical Research Council) measure: Quality of life (QoL) will be assessed using PEmb-Qol (Pulmonary Embolism Quality of Life) measure: Number of Participants with chronic thromboembolic pulmonary hypertension (CTEPH). measure: Mortality of all causes. measure: Percentage of patients with RPVO (> 5%) on V/Q SPECT/CT imaging using Technegas and Krypton. measure: The following score will be computed : PADIS-PE score. measure: Other predictors of adjudicated symptomatic objectively confirmed recurrent VTE at 2 years including: gender measure: Other predictors of adjudicated symptomatic objectively confirmed recurrent VTE at 2 years including: obesity measure: Other predictors of adjudicated symptomatic objectively confirmed recurrent VTE at 2 years including: D-Dimer measure: Other predictors of adjudicated symptomatic objectively confirmed recurrent VTE at 2 years including: inherited or acquired thrombophilia measure: Other predictors of adjudicated symptomatic objectively confirmed recurrent VTE at 2 years including: residual vein thrombosis sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU Amiens city: Amiens zip: 80054 country: France name: Marie-Antoinette SEVESTRE, Pr role: CONTACT phone: +33322087306 email: sevestre.marie-antoinette@chu-amiens.fr lat: 49.9 lon: 2.3 facility: CHU Angers city: Angers zip: 49933 country: France name: Jeanne HERSANT, Pr role: CONTACT phone: +33661392285 email: Jeanne.hersant@chu-angers.fr lat: 47.46667 lon: -0.55 facility: CHU Brest city: Brest zip: 29609 country: France name: Pierre-Yves LE ROUX, Pr role: CONTACT phone: +33298223327 email: pierre-yves.leroux@chu-brest.fr name: Francis COUTURAUD, Pr role: PRINCIPAL_INVESTIGATOR lat: 48.3903 lon: -4.48628 facility: Hôpital Louis MourierAP-HP city: Colombes zip: 92700 country: France name: Isabelle MAHE, Pr role: CONTACT phone: +33147606490 email: isabelle.mahe@lmr.aphp.fr lat: 48.91882 lon: 2.25404 facility: CHD Vendée - La Roche sur Yon city: La Roche-sur-Yon zip: 85925 country: France name: Jean-Manuel KUBINA, Dr role: CONTACT phone: +33251446301 email: jean-manuel.kubina@ght85.fr lat: 46.66667 lon: -1.43333 facility: Kremlin-Bicêtre AP-HP city: Le Kremlin-Bicêtre zip: 94270 country: France name: David MONTANI, Pr role: CONTACT phone: +33145217976 email: david.montani@aphp.fr lat: 48.81471 lon: 2.36073 facility: CH Les Sables d'Olonne city: Les Sables-d'Olonne zip: 85340 country: France name: Nicolas BREBION role: CONTACT phone: +33251218824 email: nicolas.brebion@ght85.fr lat: 46.5 lon: -1.78333 facility: Hegp Ap-Hp city: Paris zip: 75015 country: France lat: 48.85341 lon: 2.3488 facility: CH Quimper city: Quimper zip: 29000 country: France name: Charles ORIONE, Dr role: CONTACT phone: +33298526096 email: charles.orione@ch-cornouaille.fr lat: 48.0 lon: -4.1 facility: CHU St-Etienne city: Saint-Étienne zip: 42055 country: France name: Laurent BERTOLETTI, Pr role: CONTACT phone: +33477127770 email: laurent.bertoletti@chu-st-etienne.fr lat: 45.43389 lon: 4.39 facility: CHIC Toulon city: Toulon zip: 83056 country: France name: Jean-Noël POGGI, Dr role: CONTACT phone: +33494145787 email: jean-noel.poggi@ch-toulon.fr lat: 43.12442 lon: 5.92836 facility: HIA Toulon city: Toulon zip: 83800 country: France name: Antoine-Raphaël BRONSTEIN, Dr role: CONTACT phone: +33483162553 email: antoine-raphael.bronstein@intradef.gouv.fr lat: 43.12442 lon: 5.92836 facility: CHU Toulouse city: Toulouse zip: 31059 country: France name: Alessandra BURA-RIVIERE, Pr role: CONTACT phone: +33561322438 email: bura-riviere.a@chu-toulouse.fr lat: 43.60426 lon: 1.44367 hasResults: False