hackint0sh/New-Dataset huggingface dataset:
After the augmentation or reconstruction surgery, participants will be scheduled for the following follow-up visits, (1) between 3 and 7 postoperative days, (2) between 3 and 6 postoperative weeks, (3) at 3 and (4) 6 postoperative months, and (5, 6 and 7) annually thereafter for a period of three consecutive years. In case any participant has an adverse event due to the procedure, and if required by the physician, an additional visit will be made to assess her, and this information as well as that of the scheduled visits should be recorded in the electronic data collection notebook. conditions: Breast Implant; Complications conditions: Breast Implantation; Methods, Safety and Performance conditions: Mammaplasty conditions: Breast Reconstruction conditions: Breast Augmentation studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 330 type: ESTIMATED name: Motiva Sizer measure: Motiva Sizers Safety (complications) measure: Motiva Sizers Performance (satisfaction) measure: Motiva Sizers Safety (reoperations) sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Establishment Labs status: RECRUITING city: Coyol state: Alajuela zip: 20102 country: Costa Rica lat: 10.00126 lon: -84.26124 hasResults: False
nctId: NCT06274723 id: STUDY00001220 id: 1K99CA281094-01A1 type: NIH link: https://reporter.nih.gov/quickSearch/1K99CA281094-01A1 briefTitle: Responses to E-cigarette Message Source and Presentation overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-12-31 date: 2024-12-31 date: 2024-02-23 date: 2024-02-23 name: University of Massachusetts, Worcester class: OTHER name: National Cancer Institute (NCI) briefSummary: The goal of this clinical trial is to use crowdsourcing to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who vape and do not vape. conditions: Vaping studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 800 type: ESTIMATED name: Expert name: Peer name: 1 Sided name: 2 Sided measure: Message acceptance measure: Harm perceptions measure: Psychological reactance measure: Message liking measure: Source trust measure: Attitudes measure: Behavioral intentions to vape or try vaping sex: ALL minimumAge: 18 Years maximumAge: 24 Years stdAges: ADULT typeAbbrev: SAP hasProtocol: False hasSap: True hasIcf: False label: Statistical Analysis Plan date: 2024-01-17 uploadDate: 2024-01-31T10:44 filename: SAP_000.pdf size: 176839 hasResults: False
nctId: NCT06274710 id: 23-5554 briefTitle: ODYSSEE Kidney Health Trial acronym: ODYSSEE-KH overallStatus: RECRUITING date: 2023-12-13 date: 2026-04-13 date: 2026-04-13 date: 2024-02-23 date: 2024-02-23 name: University Health Network, Toronto class: OTHER name: Sunnybrook Health Sciences Centre name: Scarborough General Hospital name: The Ottawa Hospital briefSummary: INTRODUCTION
Severe CKD is defined as a risk of greater than 10% for progressing to RRT \[home hemodialysis (HHD), home peritoneal dialysis (HPD), and transplantation\] within 2 years. There is a need to improve access to CKD self-care counselling and RRT education for patients with severe CKD. Trials of CKD self-care education have achieved therapeutic benefits with moderate to high patient-provider contact. There is high potential for a trial of digital counselling for CKD self-care and RRT education to enhance patient health and quality of life.
Separate GLMs will evaluate if Digital Counselling versus UC is independently associated with outcomes at months 6 and 12 and trial completion (median = 19; range: 12 to 27 months). Dependent variables include the KDQOL-SF, SF-36, EUROIA, PHQ-9, GAD-7, MIDLS, ESSI, PWB, BMPN, AI, as well as a modified SEMCD-6. Multivariable models will adjust for baseline assessments of each outcome and potential baseline covariates (noted above). In all GLMs, significant interactions will be followed by subgroup analyses with Bonferroni post hoc tests. conditions: Chronic Kidney Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 344 type: ESTIMATED name: ODYSSEE-KH measure: Incidence of home RRT measure: Improvement of Home RRT measure: Improvement of RRT preparation with planned dialysis access measure: Incidence of annual hospitalization rate measure: Engagement with RRT education and CKD self-care counselling resources measure: Self-reported engagement in activities for living well measure: Self-reported assessment for health-related quality of life due to kidney disease measure: Self-reported assessment of people's aspirations and goals measure: Self-reported measure of overall health (e.g. pain, mental health, physical, role and social functioning) measure: Self-reported depression measure: Self-reported perceived social support measure: Self-reported psychological wellbeing measure: Self-reported anxiety measure: Self-reported feeling of value to self and others measure: Self-reported measure of psychological wellbeing and happiness measure: Self-reported measure of overall life experience measure: Self-reported measure of well-being measure: Self-reported readiness for change (motivation) measure: Self-reported confidence in doing life activities sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Health Network status: RECRUITING city: Toronto state: Ontario zip: M2N 7A2 country: Canada name: Robert P Nolan, PhD role: CONTACT phone: (416) 340-4800 phoneExt: 6400 email: rob.nolan@uhnresearch.ca name: Karly Gunson, HBA, BHSc role: CONTACT phone: (416) 340-4800 phoneExt: 6400 email: karly.gunson2@uhn.ca lat: 43.70011 lon: -79.4163 hasResults: False
nctId: NCT06274697 id: RECHMPL22_0391 id: 2023-A01784-41 type: REGISTRY domain: ID-RCB briefTitle: Validation of a Magnetic Sensor in Arterial Flow Recording, Compared With the Reference Method, at Various Peripheral Arterial Sites acronym: COMADO overallStatus: RECRUITING date: 2024-04-02 date: 2025-04 date: 2025-04 date: 2024-02-23 date: 2024-04-11 name: University Hospital, Montpellier class: OTHER name: phymedexp briefSummary: The measurement of magnetic fields emitted by cardiac activity has already been studied in magneto-cardiography. To date, however, this technology has never been evaluated in the peripheral circulation.
Proving the validity of this prototype would make it a new diagnostic and even prognostic tool, non-invasive, less costly and more accessible than Doppler for screening peripheral arterial disease. conditions: Lower Extremity Artery Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 70 type: ESTIMATED name: Evaluation by magnetic sensor measure: Correlation of the two curve amplitudes (y) versus time (x) between the signal recording obtained by the CapMagic prototype on the radial artery and the pulsed echo-Doppler recording on the radial artery measure: Correlations of the two curve amplitudes (y) versus time (x) between the signal recording obtained by the CapMagic prototype and the pulsed echo-Doppler recording, measured on the plantar artery on one side and on the pulpal artery on the other measure: Correlation of the Pulsatility index (or Gosling Pulsatility index) between the signal recording obtained by the CapMagic prototype and the pulsed echo-Doppler recording measure: Correlation of the Systolic rise time (SRT) between the signal recording obtained by the CapMagic prototype and the pulsed echo-Doppler recording measure: Correlation of the Systolic peak between the signal recording obtained by the CapMagic prototype and the pulsed echo-Doppler recording measure: Correlation of the Type of flow according to Saint-Bonnet classification between the signal recording obtained by the CapMagic prototype and the pulsed echo-Doppler recording measure: Correlation of Presence of critical ischemia measured by the CapMagic prototype and the pulsed echo-Doppler recording sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Center status: RECRUITING city: Montpellier country: France name: Gudrun BOGE, MD role: CONTACT phone: 467336279 phoneExt: 33 email: g-boge@chu-montpellier.fr name: Gudrun BOGE role: PRINCIPAL_INVESTIGATOR lat: 43.61092 lon: 3.87723 hasResults: False
nctId: NCT06274684 id: 2023-01100 briefTitle: Feasibility of Virtual Reality Assistance in Prostate Biopsy Under Local Anesthesia. overallStatus: NOT_YET_RECRUITING date: 2024-02-19 date: 2025-05-01 date: 2025-07-01 date: 2024-02-23 date: 2024-02-28 name: University Hospital, Geneva class: OTHER briefSummary: The goal of this clinical trial is to test the impact of Virtual Reality (VR) assistance for anxiety management of patients undergoing prostate biopsies in local anaesthesia.
Researchers will compare standardised anxiety scores with a control group. conditions: Prostate Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Use of Virtual Reality Assistance during prostate biopsies measure: Anxiety level measure: Anxiety level of the surgeon measure: Biopsies complications sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06274671 id: 23-24-09 briefTitle: Glymphatic MRI in Clinically Isolated Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-05-15 date: 2025-05-15 date: 2024-02-23 date: 2024-02-23 name: University of Exeter class: OTHER briefSummary: The brain possesses a system to get rid of unwanted substances, named Glymphatic System (GS). When this system is faulty, these accumulate, there is local inflammation, and progressive death of the cells. This occurs in neurological diseases including Parkinson's, or Alzheimer's. Inflammation and progressive death of the cells are also present in another neurological disorder, named Multiple Sclerosis (MS).
The researchers have developed a new way to find signs of alteration of the GS using a scan named Magnetic Resonance Imaging (MRI) and will use it in a pilot study on patients with a condition named Clinically Isolated Syndrome (CIS), which often represents the very beginning of MS. It would therefore be demonstrated that the GS is a new mechanism of disease in CIS, which may associate with the symptoms, or the alterations in the levels of some substances in the blood suggestive of brain cells damage.
Should this study be successful, this would provide preliminary evidence to perform a larger research study to assess if GS dysfunction drives the progression of MS. conditions: Clinically Isolated Syndrome studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 30 type: ESTIMATED name: Magnetic Resonance Imaging measure: To determine that patients with CIS display alterations of the glymphatic system visible in vivo by Structural MRI measure: To determine that patients with CIS display alterations of the glymphatic system visible in vivo by microstructural MRI measure: To determine that patients with CIS display alterations of the glymphatic system visible in vivo by diffusion-weighted MRI measure: To determine that patients with CIS display alterations of the glymphatic system visible in vivo by perfusion-MRI measure: To determine that patients with CIS display alterations of the glymphatic system visible in vivo by ALS-MRI measure: To correlate in vivo measures of altered glymphatic system with MRI measures of structural integrity in CIS measure: To correlate in vivo measures of altered glymphatic system with MRI measures of disease activity in CIS measure: To correlate in vivo measures of altered glymphatic system with MRI measures of enlarged Wirchow-Robin spaces in CIS measure: To correlate in vivo measures of altered glymphatic system with MRI measures of microstructural altertions in CIS measure: To correlate in vivo measures of altered glymphatic system with MRI measures of brain perfusion in CIS measure: To correlate in vivo measures of altered glymphatic system in CIS with clinical measures of disease severity measure: To correlate in vivo measures of altered glymphatic system in CIS with fluid biomarkers of axonal injury in CIS measure: To correlate in vivo measures of altered glymphatic system in CIS with fluid biomarkers of astrocytis integrity in CIS measure: To correlate in vivo measures of altered glymphatic system in CIS with fluid biomarkers of glymphatic activity in CIS sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Exeter city: Exeter country: United Kingdom name: Edoardo R de Natale, MD role: CONTACT email: e.de-natale@exeter.ac.uk lat: 50.7236 lon: -3.52751 hasResults: False
nctId: NCT06274658 id: STUDY00006517 briefTitle: The Effects of an Acute High-intensity Exercise on Heart and Brain Function in People With Spinal Cord Injury overallStatus: RECRUITING date: 2024-02-14 date: 2025-06-30 date: 2025-08-31 date: 2024-02-23 date: 2024-02-23 name: State University of New York at Buffalo class: OTHER briefSummary: The heart and brain are regulated by the autonomic nervous system. Control of these organs can be disrupted in people with spinal cord injury (SCI). This may affect their ability to regulate blood pressure during daily activities and process the high-level information. Previous studies show that high-intensity exercise induces better outcomes on heart and information processing ability in non-injured people compared to moderate-intensity exercise. However, it is unknown the effects of high-intensity exercise on heart and brain function in people with SCI. Therefore, this study aims to examine the effects of a single bout of high-intensity interval training on heart and brain function in this people with SCI compared to age- and sex-matched non-injured controls. conditions: Autonomic Nervous System Disease conditions: Spinal Cord Injuries conditions: Cognition studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: High-intensity interval exercise measure: Low frequency of systolic blood pressure variability measure: High frequency of heart rate variability measure: Blood pressure measure: Heart rate measure: Cerebral blood flow velocity measure: Symbol Digit Matched Test score measure: California Verbal Learning Test score measure: Color-Word Stroop Test score measure: Controlled Word Association Task score sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University at Buffalo, South Campus status: RECRUITING city: Buffalo state: New York zip: 14214 country: United States name: Wenjie Ji role: CONTACT phone: 716-907-2508 phoneExt: 1 email: wji4@buffalo.edu lat: 42.88645 lon: -78.87837 hasResults: False
nctId: NCT06274645 id: IVUS CHIP China Registry briefTitle: IVUS CHIP China Registry overallStatus: RECRUITING date: 2024-03-12 date: 2026-07 date: 2028-02 date: 2024-02-23 date: 2024-04-26 name: Shanghai Zhongshan Hospital class: OTHER briefSummary: The goal of this observational study is to learn about in patients with complex coronary lesions undergoing PCI. The main question\[s\] it aims to answer are: the clinical efficacy and safety of an IVUS-guided approach in patients with complex coronary lesions undergoing PCI, as well as clinical outcomes up to 2 years. Participants will be treated with IVUS-guided PCI. conditions: Complex Higher Risk Indicated Patients Undergoing PCI studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2020 type: ESTIMATED name: The OptiCross High Definition (60 MHz) and OptiCross (40MHz) Intravascular Ultrasound (IVUS) catheter from Boston Scientific measure: Time-to-first-event analysis of these three event including cardiac death, target vessel myocardial infarction will be primarily used for clinical endpoints. measure: Time-to-first-event analysis will be primarily used for clinical endpoints. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fudan Zhongshan Hospital status: RECRUITING city: Shanghai country: China name: Chenguang Li, Doctor role: CONTACT email: li.chenguang@zs-hospital.sh.cn lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06274632 id: 2023P001913 briefTitle: ADELANTE: A Randomized Controlled Trial to Improve Engagement in Care for Latinos With HIV overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-02-28 date: 2027-02-28 date: 2024-02-23 date: 2024-04-03 name: Massachusetts General Hospital class: OTHER name: Baylor College of Medicine name: University of Miami briefSummary: The goal of this study is to test the effectiveness of ADELANTE on viral suppression among Latinos with HIV and viral non-suppression. Participants will receive ADELANTE (5-session, community health worker-delivered, problem-solving intervention) or enhanced care condition (ECC, 5 reminder phone calls). We will evaluate the overall effectiveness of ADELANTE compared with ECC on rates of viral suppression and emergency room visits and hospitalizations. Our hypothesis is that ADELANTE participants will achieve higher rates of viral suppression and will have lower rates of emergency room visits and hospitalizations compared with ECC at 12 months post-randomization. conditions: HIV/AIDS studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 250 type: ESTIMATED name: ADELANTE measure: 12-month viral suppression measure: Number of Emergency department visits measure: Number of Hospitalizations measure: 6-month viral suppression measure: Retention in care sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Miami city: Miami state: Florida zip: 33146 country: United States name: Allan Rodriguez, MD role: CONTACT phone: 305-243-3711 email: arodriguez2@miami.edu lat: 25.77427 lon: -80.19366 facility: Baylor College of Medicine city: Houston state: Texas zip: 77030 country: United States name: Thomas P Giordano, MD role: CONTACT phone: 713-798-8918 email: tpg@bcm.edu lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06274619 id: 23HH8541 id: MISP 59717 type: OTHER_GRANT domain: MSD id: 57276 type: REGISTRY domain: CPMS id: 324970 type: OTHER domain: IRAS briefTitle: Novel Mucosal Correlates Of RSV Protection In Older Adults acronym: CHIRP01 overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-02 date: 2026-02 date: 2024-02-23 date: 2024-03-07 name: Imperial College London class: OTHER briefSummary: Respiratory syncytial virus (RSV) is one of the most common causes of chest infection worldwide. Despite this, it remains an underappreciated health problem, with the first effective RSV vaccines only approved by the FDA in May 2023 and unlikely to be widely available for some time. Although RSV infection is most frequent in young children, most deaths occur in older adults, particularly in those with underlying heart and lung disease. This is believed to be due in part to the ageing immune system's reduced ability to protect against infection and symptomatic disease.
However, little is known about the way human immune responses to RSV infection in older individuals differ from those of younger people. Further understanding of the mechanisms underlying immunity and potential impairments in these higher-risk people are therefore necessary. This project aims to study the factors that influence whether or not older people develop symptomatic RSV disease in healthy older volunteers after being given an RSV-induced common cold. Samples will be taken from the blood and nose in order to identify changes in the immune system associated with susceptibility or protection in older adults. Participants will be carefully screened to ensure there are no underlying health problems that might make them more at risk of severe disease and will be monitored closely throughout the course of infection. It is anticipated that differences in immune markers in the nose and/or blood of healthy older people will predict whether or not such individuals become infected or develop symptoms. By analysing the networks of genes that are switched on and off, the aim is to identify the pathways in the immune system responsible for these differences, to ultimately develop improved diagnostic tests, vaccines and treatments. conditions: Respiratory Tract Infections studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 20 type: ESTIMATED name: RSV A Memphis 37 measure: Number of solicited and unsolicited adverse events (AEs) measure: Infection rate measure: Nasal Viral Load measure: Antibody levels by serum neutralisation assay measure: Antibody levels by ELISA sex: ALL minimumAge: 65 Years maximumAge: 75 Years stdAges: OLDER_ADULT facility: Imperial College London city: London zip: W12 0NN country: United Kingdom name: Polly Fox role: CONTACT email: polly.fox@imperial.ac.uk name: Christopher Chiu role: PRINCIPAL_INVESTIGATOR lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06274606 id: HSR230106 briefTitle: Exercise Training Study Before Bariatric Surgery acronym: BaSE overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-01-01 date: 2025-03-15 date: 2024-02-23 date: 2024-02-23 name: University of Virginia class: OTHER briefSummary: The goal of this clinical trial is to figure out if 8 weeks of walking exercise before bariatric surgery improves risk factors for diabetes and other markers of health. This is important as it may help reduce complications after surgery, improve health markers and increase physical activity levels after surgery (which is an important marker of maintaining bariatric weight loss). The main question that this study is trying to answer is whether walking improves a risk factor for type 2 diabetes called insulin sensitivity (how well your body is able to use glucose).