hackint0sh/New-Dataset huggingface dataset:
Multiple reports have demonstrated the presence of abnormal pro-inflammatory cytokine production in large-vessel vasculitis patients, particularly those with GCA, including interleukin-1 (IL-1), IL-6, IL-18, tumor necrosis factor-α (TNF-α), and interferon-γ, by T lymphocytes and macrophages. IL-6 has been implicated as a crucial cytokine in the pathogenesis of aortitis and targeting its signaling has shown promising results in treating the condition. IL-6 inhibitors such as tocilizumab have been found to effectively reduce disease activity and improve clinical outcomes in GCA patients.
The GIACTA study (GiAnt cell arteritis roActemra (tocilizumab) study) was a randomized, double-blind, placebo-controlled trial that evaluated the efficacy and safety of tocilizumab in the treatment of GCA. The study included 251 patients with newly diagnosed or relapsing GCA and found that treatment with tocilizumab significantly increased the proportion of patients who achieved sustained remission from GCA at 52 weeks, compared to placebo. Additionally, tocilizumab was associated with a lower incidence of disease flares and a reduced need for glucocorticoid therapy.
This observational study will provide important informations on the impact of Tyenne® (tocilizumab) associated with short term low dose steroids on clinical manifestations and vessel inflammation and damage in aortitis of GCA. conditions: Giant Cell Arteritis conditions: Aortitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 80 type: ESTIMATED measure: To evaluate the proportion of patients with remission of GCA measure: To assess the cumulative incidence of relapse measure: To assess the proportion of GCA in remission (according to EULAR consensus definitions) after treatment start measure: To assess the cumulative dose of prednisone measure: To assess the cumulative incidence of severe adverse events measure: To assess the proportion of radiological vascular progression measure: To assess the cumulative incidence of vascular revascularization procedures sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06271005 id: 000824 briefTitle: Neurological Dry Eye Study Stimulating Both Lacrimal and Vagus Nerves overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-10-01 date: 2024-10-01 date: 2024-02-21 date: 2024-02-21 name: Genetic Disease Investigators class: OTHER briefSummary: This is a study on neurological dry eye disease, focusing on a patented over-the-counter supplement supporting tear production neurologically, including the lacrimal and vagus nerves. conditions: Dry Eye Disease conditions: Dry Eye studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 75 type: ESTIMATED name: NeuroTears name: Placebo measure: OSDI sex: ALL minimumAge: 20 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06270992 id: 123R030 briefTitle: Oral Microbiome Diagnostics of Lung Cancer overallStatus: RECRUITING date: 2023-11-15 date: 2025-02-15 date: 2026-05-15 date: 2024-02-21 date: 2024-02-21 name: TC Erciyes University class: OTHER name: THE SCIENTIFIC AND TECHNOLOGICAL RESEARCH COUNCIL OF TÜRKİYE briefSummary: The study aims to develop a deep learning-based diagnostic method for lung cancer using the oral microbiome. This innovative approach involves establishing an observational cohort of 576 individuals, including lung cancer patients, non-cancerous benign lung disease patients, and healthy controls, to collect tongue swab samples for 16S rRNA sequencing. Additionally, an international cohort of approximately 1700 individuals will be formed using in silico data. The project will utilize deep learning methods to analyze all data integratively and develop an AI diagnostic algorithm capable of distinguishing lung cancer patients from others. The diagnostic method's performance will be tested in a pilot clinical trial with 96 individuals using a PRoBE design. Led by experts in chest surgery, molecular microbiology, and bioinformatics, the project spans over 30 months and aims to create a non-invasive, easily accessible lung cancer screening method that could lead to significant diagnostic advancements and potential spin-off companies in the field of liquid biopsy/molecular diagnosis. conditions: Lung Cancer studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 676 type: ESTIMATED name: NCCN (National Comprehensive Cancer Network) diagnosis measure: Diagnostics accuracy assessment sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Erciyes University Hospital status: RECRUITING city: Kayseri zip: 38039 country: Turkey name: Aycan Gundogdu, PhD role: CONTACT phone: +90 352 207 6666 email: agundogdu@erciyes.edu.tr lat: 38.73222 lon: 35.48528 hasResults: False
nctId: NCT06270979 id: ISHA briefTitle: Intrinsic Capacity and Functional Ability Monitoring With an Integrated Data Eco-System for Healthy Ageing. acronym: ISHA overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-04-01 date: 2024-02-21 date: 2024-02-21 name: Prof. Ivan Bautmans class: OTHER name: Leiehome vzw name: University Hospital, Antwerp name: Universiteit Antwerpen name: INNOVIRIS name: AAL briefSummary: In this study, 120 older adults (aged 65 years or older) either patients undergoing rehabilitation or older nursing home residents will be provided with an Eforto® device and the eco-System for Healthy Ageing (ISHA) mobile application to self-monitor intrinsic capacity for 4 months (if needed with assistance by an (in)formal caregiver). Preferably, the participants will use their own smartphone because mitigating smartphone-use-related issues.
nctId: NCT06270966 id: 28287 08/11/2023 briefTitle: Cognitive Remediation VR Tool for People With MCI: a Feasibility RCT overallStatus: NOT_YET_RECRUITING date: 2024-03-07 date: 2024-12-01 date: 2025-12-01 date: 2024-02-21 date: 2024-02-21 name: University of Cagliari class: OTHER briefSummary: The need to promote research in active aging trough multidisciplinary and innovative approaches is strongly indicated by the European Union. Our study aims to assess the feasibility and provide a preliminary measure of effectiveness for an intervention using immersive virtual reality (VR) technology for cognitive remediation (CR) in individuals with Mild Cognitive Impairment (MCI) conditions: Mild Cognitive Impairment conditions: Cognitive Remediation conditions: Virtual Reality conditions: Psychiatric Rehabilitation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized Controlled Trial primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Virtual Reality Cognitive Remediation measure: Side effects; Dropout rates; Proportion of recruited participants among those considered eligible measure: Short Form Health Survey, 12 items (SF-12) measure: Brief Social Rhythms Scale (BSRS) measure: Patient Health Questionnaire (PHQ-9) measure: Generalized Anxiety Disorder-7 item (GAD-7) measure: Addenbrooke's Cognitive Examination (ACE-R) measure: Matrix test measure: Rey's Word Test measure: Trail Making Test (TMT) measure: Digit Span measure: Stroop Test measure: Frontal Assessment Battery (FAB) measure: Cognitive Estimates Test (CET) measure: Rey Figure Test sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: San Giovanni di Dio Hospital city: Cagliari state: CA zip: 09100 country: Italy lat: 39.23054 lon: 9.11917 hasResults: False
nctId: NCT06270953 id: DZ_NX_US briefTitle: Non-invasive Monitoring: Impact on Patient Management and Outcomes overallStatus: RECRUITING date: 2024-01-19 date: 2024-03-30 date: 2024-06-30 date: 2024-02-21 date: 2024-02-28 name: Turtle Shell Technologies Pvt. Ltd. class: INDUSTRY briefSummary: Enhancing patient monitoring in SNFs and ALFs is crucial due to challenges in recognizing deteriorating health. Gaps in vital sign checks lead to missed indicators and adverse outcomes. Turtle Shell Technologies' Dozee Pro NX offers continuous non-invasive monitoring, alerting healthcare providers of vital sign changes. This clinical study aims to evaluate Dozee Pro Nx's impact on patient outcomes, practitioner efficiency, and healthcare costs in SNFs and ALFs, addressing gaps in care delivery. conditions: No Specific Medical Conditions or Disease States studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 150 type: ESTIMATED name: Dozee Pro NX measure: Number of Care Escalation and/or Transfers (Subgroup- ER visits, Surgical Interventions & Hospitalizations, ICU Admissions), measure: HCP experience response data measure: Care pathway mapping sex: ALL minimumAge: 18 Months maximumAge: 120 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Oak Village Healthcare status: RECRUITING city: Lake Jackson state: Texas zip: 77566 country: United States name: Lindsay Darthard, LNFA role: CONTACT phone: 979-319-2306 email: lindsaydarthard@gcltc.com name: Lindsay Darthard, LNFA role: PRINCIPAL_INVESTIGATOR name: Marc A Wilson, MD role: SUB_INVESTIGATOR lat: 29.03386 lon: -95.43439 hasResults: False
nctId: NCT06270927 id: 00003830 briefTitle: A Feasibility Study for Randomization of Code Stroke Imaging Strategies acronym: CSI overallStatus: RECRUITING date: 2023-10-23 date: 2024-03-30 date: 2024-07-10 date: 2024-02-21 date: 2024-02-21 name: University of Texas at Austin class: OTHER name: Lone Star Stroke Research Consortium briefSummary: The purpose of this study is to test feasibility of a comparative effectiveness framework for acute stroke imaging using prospective electronic health data. This is a prospective, cohort feasibility study of patients presenting to the Emergency Department with suspected acute ischemic stroke. The clinical stroke team will not be blinded to the imaging modality given the nature and purpose of the interventions/imaging. Knowledge of the imaging modality used and the knowledge gained from the resulting data will need to be considered for treatment decisions. Blinding will be maintained for data abstraction and analyses. Analysis will be on an "intent-to-scan" basis and all qualifying patients will be included in their assigned cohort. conditions: Brain Ischemia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 600 type: ESTIMATED name: MRI name: CT measure: compliance sex: ALL minimumAge: 18 Years maximumAge: 120 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ascension Seton status: RECRUITING city: Austin state: Texas zip: 78712 country: United States name: Adrienne N Dula, PhD role: CONTACT phone: 512-495-5922 email: adrienne.dula@austin.utexas.edu name: Karinne Berstis, MA role: CONTACT email: karinne@austin.utexas.edu lat: 30.26715 lon: -97.74306 hasResults: False
nctId: NCT06270901 id: BMEL: 2822EPS008 briefTitle: Acute Effects of Legume-enriched Meals Compared to Western Diet Meals on Postprandial Metabolism in Participants With Increased Cardiometabolic Risk acronym: LeguPlan_1 overallStatus: RECRUITING date: 2024-05-01 date: 2024-07-30 date: 2024-07-30 date: 2024-02-21 date: 2024-04-15 name: University of Bonn class: OTHER name: Federal Ministry of Food and Agriculture (BMEL) name: Federal Office for Agriculture and Food (BLE) briefSummary: The aim of the study is to investigate the postprandial effects of legume-enriched meals compared to Western Diet meals on postprandial metabolism. In this context, older adults with increased risk for cardiometabolic diseases consume 4 mixed meals with 36 g or 62 g of protein either designed according to the Planetary Health Diet with legumes as primary protein source or the Western Diet with animal foods as primary protein source, in a randomized order. In a postprandial observation period of 6 hours, parameters of lipid metabolism, glucose and insulin metabolism, amino acid profile, as well as markers of inflammation and vascular function are analysed. Furthermore, neuropsychological parameters and satiety-associated hormones are investigated. conditions: Cardiovascular Diseases conditions: Metabolic Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 30 type: ESTIMATED name: High Protein Planetary Health Diet name: Low Protein Planetary Health Diet name: High Protein Western Diet name: Low Protein Western Diet measure: Parameters of lipid metabolism in blood measure: Parameters of lipid metabolism in blood measure: Parameters of lipid metabolism in blood measure: Parameters of lipid metabolism in blood measure: Parameters of lipid metabolism in blood measure: Parameters of glucose metabolism in blood measure: Parameters of glucose metabolism in blood measure: Parameters of glucose metabolism in blood measure: Parameters of glucose metabolism in blood measure: Parameters of glucose metabolism in blood measure: Blood amino acid profile measure: Blood urea measure: Uric acid in blood measure: Parameters of hunger and satiety in blood measure: Parameters of endothelial function in blood measure: Parameters of inflammation in blood measure: Endothelial function measure: Neuropsychological parameters measure: Neuropsychological parameters measure: Neuropsychological parameters sex: ALL minimumAge: 50 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Bonn, Institute of Nutritional and Food Sciences, Nutrition Physiology status: RECRUITING city: Bonn state: North-Rhine Westphalia zip: 53115 country: Germany name: Sarah Egert, Prof. Dr. role: CONTACT phone: + 49 (0) 228 / 73 59 email: s.egert@uni-bonn.de lat: 50.73438 lon: 7.09549 hasResults: False
nctId: NCT06270888 id: IRB23-1011 briefTitle: Hypofractionation (Radiation) Trial for Multiple Myeloma overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2028-05-01 date: 2028-05-01 date: 2024-02-21 date: 2024-02-21 name: University of Chicago class: OTHER briefSummary: This study if for people who have been diagnosed with multiple myeloma and their doctors are recommending radiation to help treat it. Typically, radiation consists of 2-3 weeks of external beam radiation therapy. Doctors leading this study would like to see if a shorter radiation course (i.e., hypofractionation) for pelvic radiation is safe for multiple myeloma. Because participants in this study will receive a shortened radiation course, each daily treatment dose that is delivered would be slightly higher than normal. This higher daily dose would be delivered because the study team would like to see if higher doses of radiation are as safe given over a shorter number of days compared to 2-3 weeks. The purpose of this study is to make sure that hypofractionation is safe and effective for individuals with multiple myeloma. conditions: Multiple Myeloma studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Radiation measure: Maximum Tolerated Dose of Radiation of Per Fraction measure: Rate of Grade 3 or Higher Adverse Events measure: Rate of Long-Term Adverse Events measure: Overall Response Rate measure: Progression-free Survival measure: Local Control of the treated Lesion sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The University of Chicago Comprehensive Cancer Center city: Chicago state: Illinois zip: 60637 country: United States lat: 41.85003 lon: -87.65005 hasResults: False
nctId: NCT06270875 id: PROJECT ADAPT-HF briefTitle: Addressing Pain Through Navigator-Led Palliative Care Optimized for Heart Failure (ADAPT-HF) acronym: ADAPT HF overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-03 date: 2025-01-03 date: 2024-02-21 date: 2024-03-07 name: University of Alabama at Birmingham class: OTHER briefSummary: Using the MOST framework, factorial pilot design, and an iterative, community-based process, the purpose of this study is to pilot test to further develop and refine a palliative care (PC) intervention addressing pain of Black adults (age \> 18) with advanced HF. Thirty-six persons with advanced heart failure (HF) will be randomized to receive one of 16 conditions (different combinations of navigator coach-delivered PC pain intervention components). conditions: Heart Failure NYHA Class III conditions: Heart Failure NYHA Class IV conditions: Chronic Illness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Data collectors and principal investigator will be blind to participant condition; participants will be instructed NOT to discuss their assignment with data collectors. Trials participants will know their intervention condition as will the palliative care coach involved in delivering the intervention. whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 36 type: ESTIMATED name: ADAPT HF measure: Feasibility of Intervention Delivery and Data Collection measure: Acceptability of Intervention Measure (AIM) measure: PROMIS Pain Intensity Scale measure: Pain Interference Scale Short Form 6b measure: Feasibility of Intervention Measure measure: Edmonton Symptom Assessment Scale (ESES-r) measure: Kansas City Cardiomyopathy Questionnaire- Short Form measure: Hospital Anxiety and Depression Scale (HADS) measure: PROMIS General Self-efficacy measure: Self-care of Heart Failure Index measure: Multidimensional Scale of Perceived Social Support (MSPSS) measure: Patient Activation Measure (PAM) Short Form measure: Brief Multidimensional Measure of Religiousness / Spirituality (BMMRS) - 6-item subscale for Religious/Spiritual Coping + 1 overall Q measure: Connor-Davidson Resilience Scale (CD-RISC-10) measure: Discrimination in Medical Settings Scale Scale measure: Cost/Resource Utilization Form measure: SF Global Health Scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06270862 id: SSHRC-PEG2023-AAT briefTitle: A Digital Active Aging Training Program for Older Adults acronym: AAT overallStatus: RECRUITING date: 2024-04-08 date: 2024-10-30 date: 2024-12-31 date: 2024-02-21 date: 2024-04-10 name: Toronto Metropolitan University class: OTHER name: Social Sciences and Humanities Research Council of Canada name: AGE-WELL and the Canadian Frailty Network name: Cogniciti name: Cognifit name: Aging in Cloud briefSummary: The proposed project aims to develop and validate a multi-dimensional digital active aging program integrated with resilience to promote the biopsychosocial functions of older adults aged 60, including Chinese older immigrants in Canada (Study 1) and English-speaking White Canadian older adults (Study 2).
The proposed study takes a typical pretest-training-posttest design. Pretest and posttest: a battery of outcome measures on physical, psychological, and social functions will be administered to all participants. Data will also be used to identify sociodemographic risk predictors for outcome variables (i.e., biopsychosocial functions and resilience). Training: the participants will be randomly assigned to three arms to receive 4 weeks of 16 training/practice/control treatment sessions delivered via Zoom.
In the "active aging with resilience (AR)" condition, participants will complete physical, cognitive, and social engagement training modules, starting with a 30-min resilience-building module. The traditional "active aging" (AA) training involves the same multi-domain active aging training without the initial resilience-building module. The "workshop training" (WT) control condition involves workshops following the same 4-week schedule on aging-related topics. conditions: Healthy Aging conditions: Cognitive Change conditions: Psychological Stress conditions: Loneliness conditions: Social Interaction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE whoMasked: PARTICIPANT count: 240 type: ESTIMATED name: Resilience training name: cognitive training name: physical exercise name: social interaction name: workshop series measure: Exercise Self-efficacy level (ESES) measure: the 5-item World Health Organization WellBeing Index (WHO-5) measure: Kessler Psychological Distress Scale (K10) measure: Multidimensional Scale of Perceived Social Support (MSPSS) measure: Conner-Davidson Resilience Scale 10-item (CD RISC-10) measure: Emotional regulation Questionnaire (ERQ) measure: Positive and Negative Affect Schedule (PANAS) measure: Visual working memory test measure: Divided attention test measure: Visual memory test measure: Stroop test measure: Sustained attention to response test measure: Satisfaction with life scale (SWLS) measure: Instrumental Activities of Daily Living(IADL) measure: The 6-item De Jong Gierveld Loneliness Scale measure: The Brief Approach/Avoidance Coping Questionnaire (BACQ) sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cognitive Aging Lab status: RECRUITING city: Toronto state: Ontario zip: M5B 2K3 country: Canada name: Lixia Yang, PhD role: CONTACT phone: 416-979-5000 phoneExt: 556522 email: lixiay@torontomu.ca name: Lixia Yang, PhD role: PRINCIPAL_INVESTIGATOR lat: 43.70011 lon: -79.4163 hasResults: False
nctId: NCT06270849 id: MTU-EC-SU-0-002/66 briefTitle: Validity and Reliability of ICIQ-FLUTS LF in Thai Version and Correlation With IPSS overallStatus: COMPLETED date: 2023-02-24 date: 2023-12-31 date: 2024-01-20 date: 2024-02-21 date: 2024-02-21 name: Thammasat University Hospital class: OTHER briefSummary: The investigators recruited participants, who were female with LUTS 50 participants for known group validity and 80 normal control females to evaluate for construct validity and test for reliability by statistical analysis. conditions: Validity of Thai Version of the ICIQ-FLUTS LF Questionnaire conditions: Reliability of Thai Version of the ICIQ-FLUTS LF studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 130 type: ACTUAL name: Questionnaire measure: How well the ICIQ-FLUTS LF questionnaire in the Thai version can differentiate between females with LUTS and normal females, was assessed by the construction validity. measure: The correlation between items within a subscale of the ICIQ-FLUTS LF questionnaire assessed by internal consistency. measure: The consistency of the repeated measurements by the Thai version of the ICIQ-FLUTS LF was assessed by the test-retest reliability. measure: The correlation between the IPSS questionnaire and ICIQ-FLUTS LF questionnaire was assessed by convergent validity. sex: FEMALE minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Thammasat University Hospital city: Khlong Luang state: Pathumthani zip: 12120 country: Thailand lat: 14.06467 lon: 100.64578 hasResults: False
nctId: NCT06270823 id: NIMR/HQ/R.8a/Vol.IX/4331 briefTitle: Reducing Respiratory Distress After Elective Caesarean Birth Through Knee-chest-flexion: a Randomized Controlled Trial overallStatus: RECRUITING date: 2024-02-14 date: 2025-02-14 date: 2025-02-14 date: 2024-02-21 date: 2024-02-21 name: Kilimanjaro Clinical Research Institute class: OTHER name: Leiden University Medical Center briefSummary: Planned caesarean birth is a risk factor for the development of neonatal respiratory distress commonly known as transient tachypnoea of the newborn. This is due to the absence of labor physiology which facilitates the clearance of fetal lung fluid. We hypothesized that by mimicking flexion induced by uterine contractions by manually performing knee-to-chest flexion directly at birth to achieve expulsion of excess lung liquid, we could reduce the incidence of respiratory distress in term children born by planned CS.