hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06274268 id: CHMS23006 briefTitle: Effect of Sarcopenia on the Occurrence of Toxicity Related to Anti-cancer Treatments acronym: SARC-ONCO overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-05-01 date: 2028-05-01 date: 2024-02-23 date: 2024-02-23 name: Centre Hospitalier Metropole Savoie class: OTHER name: Université Savoie Mont Blanc briefSummary: The goal of this clinical trial is to learn about the effect of sarcopenic status on the occurrence of treatment-related toxicity during the first course of anti-cancer treatment in several types of cancers.
The evaluation will focus on the body composition of the participants, assessed by impedancemetry, and on their muscular performance by standardized physical tests. conditions: Sarcopenia conditions: Oncology conditions: Physical Inactivity conditions: Toxicity Due to Chemotherapy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Prospective cohort study primaryPurpose: DIAGNOSTIC masking: NONE count: 700 type: ESTIMATED name: Sarcopenia diagnostic test measure: Event-free survival according to sarcopenic statut measure: Event-free survival according to the link between: 1/ the dose/lean mass ratio and 2/ body composition and the occurrence of adverse events linked to treatment. measure: Progression free-survival measure: Overall survival measure: Objective response rate at 6 and 12 months measure: Number of patients classified as sarcopenic by BIA method and CT method. measure: Exploratory: Event-free survival during PACLITAXEL protocol measure: Exploratory: Level of spontaneous activity measurement by accelerometry (m.s-2). measure: Exploratory: RCB-based objective response rate at 6 and 12 months sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06274255 id: BalikesirU briefTitle: Serum Magnesium Level and Pediatric Migraine acronym: Migraine overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-04-10 date: 2024-05-15 date: 2024-02-23 date: 2024-02-23 name: Mersin University class: OTHER briefSummary: Aim: The purpose of this study is to compare serum magnesium levels between patients with migraine and a control group and to examine the relationship between the frequency and duration of attacks in patients with migraine and mean serum magnesium levels.
Material-Method: Patients diagnosed presenting to the Balıkesir University Medical Faculty pediatric neurology clinic between 01.09.2019 and 01.04.2023 and diagnosed with migraine were enrolled retrospectively. Patients diagnosed with migraine were included as the study group and healthy children presenting to the pediatric neurology clinic in the same period as the control group. The demographic characteristics (age, sex, and body mass index) of the patient group and their clinical (attack durations and frequencies, symptoms during attacks, and treatments) and laboratory (hemoglobin, hematocrit, platelet, glucose, calcium, magnesium, vitamin D, folate and ferritin levels) characteristics were recorded. conditions: Migraine, Magnesium, Pediatric studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 60 type: ESTIMATED measure: Serum Magnesium Level and Pediatric Migraine measure: Serum Magnesium Level and Pediatric Migraine sex: ALL minimumAge: 72 Months maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Hilal Aydın city: Balıkesir state: Türkiye zip: 33343 country: Turkey name: Hilal Aydın, assoc. Dr. role: CONTACT phone: +902666121461 email: drhilalaydin@gmail.com name: Hilal Aydın, assoc. Dr. role: CONTACT phone: +905072607541 email: drhilalaydin@gmail.com lat: 39.64917 lon: 27.88611 facility: Aysen Orman city: Mersin state: Türkiye zip: 33343 country: Turkey lat: 36.79526 lon: 34.61792 facility: MersinU city: Mersin state: Türkiye zip: 33343 country: Turkey name: Aysen Orman role: CONTACT email: ormanaysen709@gmail.com name: Aysen Orman role: CONTACT phone: 3242410000 phoneExt: 2646 email: ormanaysen709@gmail.com lat: 36.79526 lon: 34.61792 facility: Aysen Orman city: Mersin state: Türkiye zip: 38000 country: Turkey name: Aysen Orman, assoc. Dr. role: CONTACT phone: +903242410000 phoneExt: +903242410000 email: ormanaysen709@gmail.com name: Aysen Orman, assoc. Dr. role: PRINCIPAL_INVESTIGATOR lat: 36.79526 lon: 34.61792 hasResults: False
nctId: NCT06274242 id: MU-CIRB 2022/300.0711 briefTitle: Mixed Natural Prebiotic-Fibers Impact on Stool Frequency and Fecal Microbiota in Constipated Thai Adults overallStatus: ACTIVE_NOT_RECRUITING date: 2023-03-10 date: 2023-07-22 date: 2024-04-19 date: 2024-02-23 date: 2024-02-23 name: Mahidol University class: OTHER briefSummary: Mixed Natural Prebiotic-Fibers Impact on Stool Frequency and Fecal Microbiota in Constipated Thai Adults: A Randomized Clinical Trial. conditions: Constipation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 98 type: ACTUAL name: Haruna name: Placebo Powder measure: Change in Stool Frequency measure: Change in Fecal Microbiota measure: Change in Stool consistency sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Mahidol University city: Nakhon Pathom zip: 73170 country: Thailand lat: 13.8196 lon: 100.04427 hasResults: False
nctId: NCT06274229 id: EA4/252/23 briefTitle: DivAirCity Social Health Survey acronym: DivAirCitySH overallStatus: RECRUITING date: 2024-02-20 date: 2024-12-31 date: 2025-12-31 date: 2024-02-23 date: 2024-02-23 name: Charite University, Berlin, Germany class: OTHER name: Universitat Politècnica de València name: Universitatea din Bucuresti name: University of Aarhus name: Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy name: European Commission briefSummary: To reduce stress among urban residents, the consortium members of the European Council Horizon 2020 research program DivAirCity install different stress reducing, noise reducing and air quality improving means in the five cities of the consortium. This study measures physiological and psychological stress and health factors before and after the implementation of the project (at intervention sites) and compares the change (improvement) to the change in comparable places where no means were installed (control site). conditions: Psychological Stress conditions: Psychological Well-Being conditions: Pollution; Exposure studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: Air pollution and noise reducing installations measure: WHO-5 Well-being Scale measure: Kessler K6 psychological distress measure: ASKU questionnaire measure: Questionnaire for General Physiological Health measure: Questionnaire about feelings of safety and security at the site sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Charité -- Universitaetsmedizin Berlin status: RECRUITING city: Berlin zip: 14109 country: Germany name: Farid I Kandil, PhD role: CONTACT phone: +491605631744 email: farid-ihab.kandil@charite.de lat: 52.52437 lon: 13.41053 hasResults: False
nctId: NCT06274216 id: 4381021ABOS briefTitle: The Effect of Vitamin D Supplementation on Dental Implant Osseointegration: A Randomized Controlled Trial overallStatus: COMPLETED date: 2021-09-01 date: 2022-03-30 date: 2022-04-01 date: 2024-02-23 date: 2024-02-23 name: Ziauddin University class: OTHER briefSummary: Dental implantation is a new technique for the single or more missing tooth replacement. Dental professionals might utilize the findings of this investigation to generate local data and learn more about how vitamin D affects bone metabolism and implant osseo-integration. The long-term success of dental implants would also be enhanced and preserved with the right medical use of vitamin D conditions: Osseointegration Failure of Dental Implant studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The research commences through a self-administered questionnaire such as age, gender, weight, height, BMI, smoking habits, sun exposure, and employment status.
Following the intervention period, the implants are allowed to cure adequately primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: Groups A and B were created out of all patients who had signed up. Patients in group A received 5000 IU of vitamin D3 orally every day for 12 weeks , whereas patients in group B received a placebo. Patients were blinded to the study medication. The implants were then allowed to cure adequately and submerged for a further three months. Patients were summoned back three months later to un-cover the implant.
Additionally, change in vitamin D levels were also assessed pre-operatively and post-operatively at 3 months. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 100 type: ACTUAL name: Vitamin D3 name: Vitamin E 400 measure: Osseo-integration is measured by evaluating the ISQ value (Implant Stability Quotient, ranging from 1-100) measure: Evaluation of Mean Change in Serum Vitamin D Levels in Dental Implant Patients with and without Vitamin D Supplementation at a Tertiary Care Hospital sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Afifa Razi city: Karachi state: Sindh zip: 74700 country: Pakistan lat: 24.8608 lon: 67.0104 hasResults: False
nctId: NCT06274203 id: 10584-2/5-2023 briefTitle: High Dose Vitamin D Supplementation in Children With Sickle Cell Disease overallStatus: COMPLETED date: 2023-05-03 date: 2024-01-30 date: 2024-02-10 date: 2024-02-23 date: 2024-02-23 name: Zagazig University class: OTHER_GOV briefSummary: Suboptimal vitamin D status is well reported in sickle cell disease (SCD) patients and associated with a negative impact on health-related quality of life (HRQL). The investigators enrolled 42 SCD patients and 42 healthy controls, subjects within each group received monthly oral vitamin D3 dose according to the baseline status of vitamin D as follows: sufficient: 100,000 IU, insufficient: 150,000 IU, and deficient: 200,000 IU. The investigators assessed safety and efficacy on normalization of vitamin D level, bone mineral density (BMD), hand grip strength (HGS), and HRQL. conditions: Sickle Cell Disease conditions: Vitamin D Deficiency conditions: Health Related Quality of Life conditions: Hand Grip Strength conditions: Bone Mineral Density studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 75 type: ACTUAL name: Vitamin D3 measure: Serum 25(OH)D level measure: Bone mineral density (BMD) measure: Maximum handgrip strength (HGS) measure: Health related quality of life (HRQL) measure: Serum concentrations of C reactive protein (CRP) measure: Serum concentrations of Erythrocyte sedimentation rate (ESR) measure: Safety reporting of any adverse events measure: Safety measurements of serum Ca measure: childhood health assessment measure: Safety measurements of serum 25(OH)D levels sex: ALL maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Zagazig university city: Zagazig state: Sharkia zip: 44519 country: Egypt lat: 30.58768 lon: 31.502 hasResults: False
nctId: NCT06274190 id: S68746 briefTitle: Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diary acronym: Treatable overallStatus: NOT_YET_RECRUITING date: 2024-04-29 date: 2025-10 date: 2026-03 date: 2024-02-23 date: 2024-04-08 name: KU Leuven class: OTHER name: Universitaire Ziekenhuizen KU Leuven briefSummary: Colorectal cancer is the 2nd and 3rd most common cancer in respectively women and men, of which about 40% is located in the rectum. The gold standard treatment for rectal cancer (RC) is a low anterior resection, combined with chemoradiotherapy. However, this treatment will negatively impact different aspects of bowel function and the patients' quality of life. These bowel symptoms often remain prevalent, even at 12 months after RC treatment. Most assessment tools are however not capable of capturing the full range or therapeutic-related evolution of these bowel symptoms. Consequently, the aim is to develop a validated bowel diary for diagnosing and evaluation of all bowel symptoms. conditions: Rectal Cancer conditions: LARS - Low Anterior Resection Syndrome studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 118 type: ESTIMATED name: bowel e-diary measure: Selection of items for the newly developed bowel diary measure: Assessment of content validity of the newly developed bowel diary in a post-Delphi patient focus group consisting of 8-12 participants measure: The usability of the newly developed e-diary, assessed with the System Usability Scale (SUS) in patients after rectal surgery for rectal cancer measure: The usability of the newly developed e-diary will be evaluated through conversations with patients who have undergone rectal surgery for rectal cancer, after these patients have used the e-diary for seven consecutive days measure: Construct validity of the newly developed bowel e-diary measure: Criterion validity of the newly developed bowel e-diary measure: Test-retest reliability of the newly developed bowel e-diary measure: Responsiveness of the newly developed bowel e-diary in patients after rectal surgery for rectal cancer. The newly validated e-diary is the primary outcome. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06274177 id: BTL-785_CTUS1400 briefTitle: Evaluation of the BTL-785F Device for Submental Fat Reduction and Neck Rejuvenation overallStatus: ACTIVE_NOT_RECRUITING date: 2023-07-26 date: 2024-04-01 date: 2024-04-01 date: 2024-02-23 date: 2024-02-23 name: BTL Industries Ltd. class: INDUSTRY briefSummary: This study will evaluate the clinical safety and the performance of the BTL-785F system equipped with the BTL-785-7 applicator for non-invasive reduction of submental fat and skin laxity treatment. conditions: Fat Burn studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 37 type: ACTUAL name: BTL-785-7 measure: Submental fat thickness reduction measure: Incidence of Treatment-related Adverse Events measure: Change on the Clinician Reported - Submental Fat Rating Scale score measure: Satisfaction Assessed by the Satisfaction Questionnaire measure: Change in the submental-cervical angle measure: Comfort Assessed by Therapy Comfort Questionnaire sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Precision Skin LLC city: Davie state: Florida zip: 33328 country: United States lat: 26.06287 lon: -80.2331 facility: Chicago Cosmetic and Dermatologic Research city: Chicago state: Illinois zip: 60654 country: United States lat: 41.85003 lon: -87.65005 facility: New Jersey Plastic Surgery (NJPS) city: Montclair state: New Jersey zip: 07042 country: United States lat: 40.82593 lon: -74.20903 facility: Gentile Facial Plastic and Aesthetic Laser Center city: Youngstown state: Ohio zip: 44512 country: United States lat: 41.09978 lon: -80.64952 hasResults: False
nctId: NCT06274164 id: H-54820 / RAI1 briefTitle: Clinical and Molecular Biomarker Studies in RAI1 (Retinoic Acid-Induced 1) -Related Disorders overallStatus: RECRUITING date: 2024-03-13 date: 2027-03 date: 2027-03 date: 2024-02-23 date: 2024-04-01 name: Baylor College of Medicine class: OTHER name: Doris Duke Charitable Foundation briefSummary: Currently, there is no clinically available genetic-based treatment for RAI1 (Retinoic Acid-Induced 1) -related disorders other than symptomatic management and there are no established clinical or molecular biomarkers that could be used as measures for the efficacy of therapy in future treatment studies. Biomarkers are measures of what is happening inside the body, shown by the results of laboratory, imaging or other tests.
Researchers will compare patients' blood to control group's blood for biomarker studies. conditions: RAI1 Gene 17P11.2 Deletion+Duplication studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 90 type: ESTIMATED name: Electroencephalography/Polysomnography (EEG/PSG) name: Skin Biopsy name: Blood draw measure: Rate of neurological clinical finding measure: Rate of electroencephalogram (EEG) and/or sleep abnormalities measure: Concentration of downstream molecular pathway interactors of RAI1 sex: ALL minimumAge: 1 Month maximumAge: 80 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Texas Children's Hospital status: RECRUITING city: Houston state: Texas zip: 77030 country: United States name: Davut Pehlivan, MD role: CONTACT phone: 713-798-6970 email: pehlivan@bcm.edu lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06274151 id: H-22038917 briefTitle: Optimal Treatment of Acute Skeletal Muscle Injury overallStatus: NOT_YET_RECRUITING date: 2024-02-15 date: 2025-07-31 date: 2029-12-31 date: 2024-02-23 date: 2024-02-23 name: Bispebjerg Hospital class: OTHER briefSummary: Acute muscle strain injuries occur both during sports, in leisure time activities and during manual occupation and represent a major clinical challenge and has societal economic costs. The recovery time is long and a substantial injury recurrence is observed. Despite current best evidence rehabilitation with early mechanical loading, a significant loss of muscle mass, fatty infiltration and formation of scar tissue is reported.
We investigate here whether a pharmacological inhibition of inflammatory pathways in the 2nd week following a muscle strain injury will provide a better clinical outcome and an advantageous cellular profile than rehabilitative training alone would. conditions: Muscle Strain, Multiple Sites conditions: Inflammation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: Naproxen 500 Mg name: Rehabilitation name: Placebo measure: Effect of anti-inflammatory medicine on cellular profile in skeletal muscle measure: Functional outcome performance measure: Functional outcome re-injury rate measure: Functional outcome Patient Related Outcome Measures (PROM) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06274138 id: HAPTONOMY briefTitle: The Enchanting Symphony of Haptonomy's Impact on Attachment and Spousal Harmony for Women Conceiving Through Infertility Treatment overallStatus: ENROLLING_BY_INVITATION date: 2024-03-15 date: 2024-03-30 date: 2025-03-15 date: 2024-02-23 date: 2024-03-05 name: Baskent University class: OTHER briefSummary: Pregnancies resulting from infertility treatment are considered normal and 'low-risk' in some countries, they often entail significant stress. Prenatal attachment may be experienced differently by parents conceiving through fertility interventions. The rising prevalence of fertility treatments is associated with increased risks such as preterm birth, low birth weight, and perinatal mortality for pregnancies achieved through infertility treatments. Beyond medical implications, post-infertility treatment pregnancies can induce high levels of anxiety and a perception of pregnancy as risky, affecting individuals psychologically. The transition to parenthood after infertility treatment can be psychologically challenging.
Healthy prenatal attachment in expectant mothers fosters the development of a healthy role as both mother and father. Maternal bonding is closely tied to a woman's mental health during the prenatal period and her commitment to her baby. Similarly, prenatal bonding with the father sheds light on the emotional connection developing between the father and the unborn child. Active participation in prenatal experiences, such as attending ultrasound appointments or discussing parenting plans, contributes to a stronger sense of attachment for fathers and establishes a positive foundation for future bonding. Supportive partner relationships during pregnancy enhance paternal bonding and emphasize the importance of a collaborative approach to prenatal care for both parents. The prenatal period is critical for fathers to establish an early emotional connection with their unborn children, laying a positive groundwork for postnatal bonding.
Various interventions aim to enhance communication between parents and augment prenatal attachment. One such practice is haptonomy-haptotherapy. Haptotherapy focuses on restoring emotional connections, especially with one's own body. It helps individuals recognize their emotional capacities and allows them to experience these capacities through insightful conversations, therapeutic touch, and skill exercises. In the context of pregnancy, haptonomy involves physical contact between the pregnant woman, her partner, and the unborn baby. Advocates of haptonomy believe that this touch-based communication can strengthen the bond between parents and the baby, promote a sense of security, and positively influence the pregnancy experience.
Haptonomy is thought to contribute positively to the psychological well-being of women during pregnancy, birth, and the postpartum period, potentially preventing mental health issues and enhancing the health of both mother and baby. It is emphasized that haptonomy is a distinct practice focused on enhancing communication between parents and the baby. Existing literature suggests that haptonomy can increase emotional bonding during the prenatal period and may be effective for parents showing low attachment. Studies indicate that touch communication develops from the second month, involving vibrations for communicating with the fetus, ultimately increasing bonding through haptonomy. Furthermore, haptonomy is reported to enhance both spousal and parental attachment, as demonstrated in a study emphasizing increased attachment for fathers with their partners and children.
H1-3: The application of haptonomy by partners has an effect on marital adjustment in pregnant women. conditions: Infertility studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 76 type: ESTIMATED name: haptonomy measure: Marital adjustment score measure: Prenatal attachment score measure: Father attachment score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Başkent University city: Ankara country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False