hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06289400 id: KaratayUOAS briefTitle: Magnetic Field Application in Patellofemoral Pain Syndrome overallStatus: RECRUITING date: 2024-02-26 date: 2024-05-01 date: 2024-05-31 date: 2024-03-01 date: 2024-03-04 name: KTO Karatay University class: OTHER briefSummary: The purpose of this study is to examine the effect of magnetic field application used in the treatment of patellofemoral pain. conditions: Pain, Knee studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 30 type: ESTIMATED name: Magnetic field application name: Conventional treatment measure: Visual Analogue Scale (VAS) measure: 36-Item Short Form Survey (SF-36) measure: Manual Muscle Test measure: The Lower Extremity Functional Scale (LEFS) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: KTO Karatay University status: RECRUITING city: Konya country: Turkey name: Osman Karaca, PhD role: CONTACT phone: +90 444 1251 phoneExt: 7845 email: osmankaracaftr@gmail.com lat: 37.87135 lon: 32.48464 hasResults: False
nctId: NCT06289387 id: MMDEF001 briefTitle: Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes overallStatus: RECRUITING date: 2024-01-20 date: 2025-01-01 date: 2025-01-10 date: 2024-03-01 date: 2024-03-05 name: Medanta, The Medicity, India class: OTHER briefSummary: Type 2 diabetes and metabolic (dysfunction)-associated fatty liver disease (MAFLD) often exist together. The prevalence of MAFLD is about 15-30% in healthy people and around 60-70% in people with type 2 diabetes. Moreover, type 2 diabetes accelerates the progression of liver disease in MAFLD.
MAFLD is a spectrum of liver conditions, ranging from simple fatty liver (low risk for progression), progressing to steatohepatitis (MASH) with no or mild fibrosis, advanced liver fibrosis, cirrhosis, and hepatocellular carcinoma. Although diabetes is the strongest predictor of advanced fibrosis in MAFLD, however, only a small proportion of people with type 2 diabetes and MAFLD (about 5-7%) develop a clinically significant liver disease, but the burden of MAFLD is such that even a small proportion of patients developing cirrhosis will lead to a huge strain on the health care system in India. MAFLD is predicted to be the leading indication for liver transplantation in coming years. At present, MAFLD/MASH is the second most common indication for liver transplantation in the USA as well as in India.
The question is why around 5-7% patients amongst MAFLD population develop fibrosis and cirrhosis. A growing body of evidence suggest that the disease develops because of a complex process in which several factors, including genetic susceptibility and environmental insults, are involved. There are several gene variants that have been incriminated in the development and progression of MAFLD. The most common genes associated with MAFLD are PNPLA3, TM6SF2, GCKR, and MBOAT7. The loss-of-function gene variant HSD17B13 seems to protect from NAFLD. There are a few studies from India about the role of PNPLA3 and TM6SF2 in MAFLD. However, these studies used USG for the diagnosis of MAFLD, which does not provide any information regarding fibrosis of the liver. The data regarding other three genetic variants are scarce from Indian individuals. conditions: Type2diabetes studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: CROSS_SECTIONAL count: 1000 type: ESTIMATED measure: Role of the PNPLA3, TM6SF2, GCKR, MBOAT7 and HSD17B13 genetic variants in the development and progression of MASLD. measure: Correlation between body fat percentage (DEXA-measured) and the genetic variants measure: Correlation between lean body mass (as measured by DEXA) and the genetic variants measure: Correlation between bone mineral content (DEXA-measured) and the genetic variants measure: Correlation between fibrosis-4 score (FIB-4) and the genetic variants measure: Correlation between MASLD fibrosis score (NFS) and the genetic variants measure: Correlation between serum creatinine levels (eGFR) and the genetic variants sex: ALL minimumAge: 30 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Medanta Division of Endocrinology & Diabetes status: RECRUITING city: Gurgaon state: Haryana zip: 122001 country: India name: Surender, PhD role: CONTACT phone: 0124141414 phoneExt: 6596 email: yadavsurender89@gmail.com lat: 28.4601 lon: 77.02635 hasResults: False
nctId: NCT06289374 id: 23HH8340 briefTitle: Longitudinal Assessment of Biomarkers After Oesophagogastric Cancer Surgery acronym: LABS overallStatus: RECRUITING date: 2024-04 date: 2028-06 date: 2029-06 date: 2024-03-01 date: 2024-03-06 name: Imperial College London class: OTHER name: Cancer Research UK briefSummary: Oesophagogastric cancer (cancer of the gullet and stomach) is the fifth most common cancer in England and Wales with 16,000 new cases diagnosed every year. Survival rates are poor with only 15% surviving beyond 5 years. There is also increasing research to understand the cancer biology and factors allowing cancers to progress. It is likely there is a relationship between the cancer-specific microbiome, cells related to inflammation, which promotes cancer progression. The BIORESOURCE 1 study has established a comprehensive resource of matched samples from patients with oesophageal and gastric cancer. This longitudinal study aims to obtain further matched biosamples in the follow-up period after cancer surgery to find biomarkers that may predict treatment response, recurrence and/or long term prognosis. conditions: Oesophageal Adenocarcinoma conditions: Gastric Adenocarcinoma studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Biosample collection measure: Salivary microbial biomarkers to predict treatment response and long-term prognosis measure: Breath volatile organic compound profile alterations of oesophagogastric cancer pre- and post- treatment measure: Quality of life measure up to 2 years following cancer surgery using validated questionnaires sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Imperial College Healthcare NHS Trust status: RECRUITING city: London country: United Kingdom name: Bhamini Vadhwana role: CONTACT name: Professor George Hanna, PhD FRCS role: PRINCIPAL_INVESTIGATOR lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06289348 id: APHP230240 id: 2023-A00970-45 type: REGISTRY domain: ID-RCB briefTitle: Announcement of Rare Metabolic Diseases in Systematic Newborn Screening: the Phenylketonuria Experience. acronym: ANNPHE overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2027-04 date: 2024-03-01 date: 2024-03-01 name: Assistance Publique - Hôpitaux de Paris class: OTHER briefSummary: The aims of this collaborative, interdisciplinary research project are to understand and describe the psychological impact of the announcement of a rare, serious disease present since birth and detected in the context of the systematic neonatal screening (DNS), in terms of the parents' experience, but also on the part of the medical team, in order to improve its process and the support it provides for the announcement of the diagnosis. conditions: Phenylketonuria studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 80 type: ESTIMATED name: socio-psychological questionnaire name: revised event impact scale (IER-S) name: Non directive interview name: Stern interview name: semi-directive interview measure: Psychological process linked to the announcement of inherited metabolic disease for the parents measure: Psychological impact of the announcement of an inherited metabolic disease on the doctors' experience measure: Measuring awareness of inherited metabolic diseases detected by midwives measure: Measure of the impact of the announcement on parents sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hôpital Necker Enfants Malades city: Paris zip: 75015 country: France name: Pascale DELONLAY, MD, PhD role: CONTACT phone: +33 1 44 49 48 52 email: pascale.delonlay@aphp.fr lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06289335 id: HCDrIMPrieto anaesthesia briefTitle: Dexmedetomidine Compared to Ondansetron for Postanaesthetic Shivering in Patients Undergoing a Cesarean Section overallStatus: COMPLETED date: 2020-08-05 date: 2021-09-05 date: 2022-01-03 date: 2024-03-01 date: 2024-03-01 name: Hospital Central "Dr. Ignacio Morones Prieto" class: OTHER briefSummary: Evaluate the efficiency of management with intravenous dexmedetomidine compared to intravenous ondansetron to achieve the disappearance of post-anesthetic shivering in a shorter time in the obstetric patient undergoing cesarean section under regional anesthesia. conditions: Postanesthetic Excitement conditions: Cesarean Section studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 40 type: ACTUAL name: saline solution measure: Period of time measure: Adverse effects sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Hospital Central Dr. Ignacio Morones Prieto city: San Luis Potosí zip: 78290 country: Mexico lat: 22.14982 lon: -100.97916 hasResults: False
nctId: NCT06289322 id: EU101136769-CLIN1 briefTitle: AI4HOPE Dementia Pain Assessment Pilot Study 1 acronym: AI4HOPE1 overallStatus: NOT_YET_RECRUITING date: 2025-07 date: 2026-12 date: 2026-12 date: 2024-03-01 date: 2024-03-05 name: University of Bonn class: OTHER name: University College Cork name: University of Leeds name: Fundacion Intras name: Universidade do Porto name: University Medical Centre Maribor briefSummary: The pilot study will develop and test a standardized assessment toolkit that will provide conclusive information with a tolerable burden for cognitively impaired patients with dementia. conditions: Dementia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Feasibility study primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 150 type: ESTIMATED name: Digital toolkit for assessment measure: Feasibility and acceptability of toolkit measure: Accuracy of toolkit assessments measure: Effect of pain /distress interventions sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06289309 id: N41/DBS/001142 briefTitle: NerveTrend vs. NerveAssure in Prevention of Recurrent Laryngeal Nerve Injury During Thyroid Surgery overallStatus: RECRUITING date: 2024-03-01 date: 2024-12-31 date: 2025-06-30 date: 2024-03-01 date: 2024-03-01 name: Marcin Barczynski class: OTHER briefSummary: The aim of this study is to compare two distinct modes of NIM Vital application in thyroid surgery: NerveTrend vs. NerveAssure mode with respect to prevalence of early postoperative RLN injury.
The hypothesis explored in this study is that NerveTrend mode may be not inferior than NerveAssure mode in intraoperative identification of impending neural injury and in prognostication of postoperative glottis function in monitored bilateral thyroid surgery. Hence, NerveTrend mode may be considered a bridge between i-IONM and NerveAssure modes, and particularly in health care environments with limited financial resources it can be considered a substantial step forward representing a modern alternative to the NerveAssure technique.
The primary outcome measure is prevalence of recurrent laryngeal nerve (RLN) injury (%) on postoperative day 1 assessed by direct laryngoscopy. conditions: Thyroid Diseases conditions: Surgery conditions: Recurrent Laryngeal Nerve Injuries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A prospective, randomized study with 2 arms: NeveTrend vs. NerveAssure mode (n=132 patients and 264 nerves at risk, each). Patients referred to the Department of Endocrine Surgery, Jagiellonian University Medical College in Krakow, for first-time thyroid surgery from March 1, 2024 onwards will be registered. Eligible patients with either benign or malignant thyroid disease will be assessed for the study. The study protocole has been approved by the Institutional Review Board (Bioethics Committee of the Jagiellonian University). primaryPurpose: PREVENTION masking: DOUBLE maskingDescription: Both participants and outcomes assessor will be blinded to the respective group assignment. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 264 type: ESTIMATED name: Neuromonitoring of the recurrent laryngeal nerves measure: Prevalence of recurrent laryngeal nerve injury (%) assessed by direct laryngoscopy measure: Positive predictive value (%) of introperative neuromonitoring of recurrent laryngeal nerves in prognostication of postoperative glottis function assessed by direct laryngoscopy measure: Negative predictive value (%) of introperative neuromonitoring of recurrent laryngeal nerves in prognostication of postoperative glottis function assessed by direct laryngoscopy measure: Prevalence of permanent recurrent laryngeal nerve injury (%) assessed by direct laryngoscopy sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Endocrine Surgery, Jagiellonian University College of Medicine status: RECRUITING city: Krakow zip: 31-202 country: Poland name: Marcin Barczynski, MD, PhD role: CONTACT phone: +48602375939 email: marbar@mp.pl name: Marcin Barczynski, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 50.06143 lon: 19.93658 hasResults: False
nctId: NCT06289296 id: MCT briefTitle: Medium Chain Fatty Acids and Ketones acronym: MCFA overallStatus: COMPLETED date: 2022-01-01 date: 2023-09-30 date: 2023-09-30 date: 2024-03-01 date: 2024-03-01 name: University of Copenhagen class: OTHER briefSummary: 16 participants were randomized to complete two seven-day intervention periods with twice-daily consumption of Medium-chain fatty acids (MCT) or long-chain fatty acids (LCT) oil. Before and after each intervention, participants completed a five-hour experimental day evaluating the response to a first intake of the MCT or LCT oils (pre MCT or LCT), which was repeated after the intervention period of daily intake (post MCT or LCT) (Fig. The intervention periods were separated by a 2-4-week washout period. conditions: Diet, Healthy conditions: Health studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A parallel crossover design, in which a group of lean and a group of obese participants are allocated to complete two seven-day intervention periods with twice daily consumption of either medium-chain fatty acids or long-chain fatty acids. primaryPurpose: BASIC_SCIENCE masking: NONE count: 16 type: ACTUAL name: Fatty acid intake in lean and obese males measure: Ketone bodies in plasma sex: MALE minimumAge: 20 Years maximumAge: 45 Years stdAges: ADULT facility: University of Copenhagen city: Copenhagen zip: 2100 country: Denmark lat: 55.67594 lon: 12.56553 hasResults: False
nctId: NCT06289283 id: Theodor Bilharz Research Ins. briefTitle: Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. The Study Will Examine Urine and Bladder Cancer Tissues From Male Patients and Urine of Controls Using Whole Genomic Sequencing Techniques and 16S rRNA. The Aim is to Elucidate Role of Microbiota in Bladder acronym: Cancer bladder overallStatus: ACTIVE_NOT_RECRUITING date: 2023-10-12 date: 2026-04 date: 2026-12 date: 2024-03-01 date: 2024-03-01 name: Theodor Bilharz Research Institute class: OTHER briefSummary: Microbes inhabiting the urinary tract that are playing an important role in maintenance of health and the development of diseases and bladder cancer. There is correlation between initiation of bladder cancer and microbes. Urine and bladder tissues from healthy individuals and patients with bladder cancer were analyzed using 16S rRNA sequencing, results show abundant phylum. Next-generation sequencing technologies will be applied with whole genomic and 16S ribosomal RNA gene sequencing for microbiota profiling in urine and bladder tissue of male healthy individuals and patients with bladder cancer. Results will lead to prevention, diagnosis and new treatment strategies for bladder cancer. conditions: Urinary Bladder Neoplasms conditions: Microtia studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 38 type: ACTUAL name: Urine samples and tissue samples: Samples will be collected in clean leak-proof containers without disinfectant or detergent residue and with tight-fitting leak-proof lids and preserved in a refrigera measure: To characterize the microbiota in health and bladder cancer, and may lead to new prevention, diagnosis and treatment strategies for bladder cancer sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Theodor Bilharz Research Institute city: Cairo zip: 12411 country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06289270 id: Microbiota and bladder cancer briefTitle: Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. The Study Will Examine Urine and Bladder Tissues From Egyptian Male Patients and Controls Using Whole Genomic Sequencing Techniques and 16S rRNA. The Aim is to Elucidate Role of Microbiota in Bladder Cancer. acronym: Cancer bladder overallStatus: RECRUITING date: 2023-09-20 date: 2026-12 date: 2027-07 date: 2024-03-01 date: 2024-03-01 name: Theodor Bilharz Research Institute class: OTHER briefSummary: Microbes inhabiting the urinary tract that are playing an important role in maintenance of health and the development of diseases and bladder cancer. There is correlation between initiation of bladder cancer and microbes. Urine and bladder tissues from healthy individuals and patients with bladder cancer were analyzed using 16S rRNA sequencing, results show abundant phylum. Next-generation sequencing technologies will be applied with whole genomic and 16S ribosomal RNA gene sequencing for microbiota profiling in urine and bladder tissue of male healthy individuals and patients with bladder cancer. Results will lead to prevention, diagnosis, and new treatment strategies for bladder cancer. conditions: Microbiota in Patients With Urinary Bladder Carcinoma in Urine and Cancer Tissues studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 38 type: ESTIMATED measure: To characterize the microbiota in male patients with bladder cancer. sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Theodor Bilharz Research Institute status: NOT_YET_RECRUITING city: Cairo state: Giza zip: 12411 country: Egypt name: Mohamed M Wishahi, MD role: CONTACT phone: +201222247437 email: wishahi@gmx.net lat: 30.06263 lon: 31.24967 facility: Theodor Bilharz Research Institute status: RECRUITING city: Cairo zip: 12411 country: Egypt name: Mohamed M Wishahi, MD role: CONTACT phone: +201222247437 email: wishahi@gmx.net lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06289257 id: VitDAndEndomet briefTitle: Association of Vitamin D Level and Its Receptor With Endometriosis overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-07-31 date: 2024-09-30 date: 2024-03-01 date: 2024-03-01 name: Khon Kaen University class: OTHER briefSummary: Endometriosis, a condition where endometrial-like tissue grows outside the uterus, often occurs due to retrograde menstruation, where menstrual blood flows backward through the fallopian tubes into the pelvic cavity. This tissue can then implant and grow within the pelvic peritoneum. The survival of these ectopic implants leads to chronic inflammation, adhesion formation, and scarring of surrounding tissues, including the ovaries and fallopian tubes. Symptoms include cyclic pelvic pain, dysmenorrhea, dyspareunia, and infertility.
Ectopic endometrial tissue survival is not attributed to mutations but rather epigenetic changes. Studies have linked this phenomenon to genes such as KRAS (Kirsten Rat Sarcoma Virus Oncogene), involved in cell proliferation and survival. Dysregulated KRAS activity can lead to increased production of MMP-2 and MMP-9 proteins, implicated in angiogenesis and tissue invasion, facilitating the spread of endometrial tissue.
Further research is needed to fully understand the relationship between vitamin D deficiency and endometriosis severity, particularly in specific populations like the Thai population. conditions: Endometriosis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 108 type: ESTIMATED name: Vitamin D level name: Vitamin D receptor measure: Vitamin D level measure: rASRM measure: Vitamin D receptor sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Obstetrics and Gynecology, Faculty of Medicine, Khonkaen University city: Khon Kaen zip: 40000 country: Thailand name: Vitet Layanun, Doctor of Medicine role: CONTACT phone: +66850663130 email: jockvitet@hotmail.com name: Vitet Layanun, Doctor of Medicine role: PRINCIPAL_INVESTIGATOR lat: 16.44671 lon: 102.833 hasResults: False
nctId: NCT06289244 id: 6597 briefTitle: Correlation Between Muscle Strength and Thickness in Critically Ill Patients overallStatus: RECRUITING date: 2023-06-06 date: 2025-03-30 date: 2025-06-30 date: 2024-03-01 date: 2024-03-01 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico class: OTHER briefSummary: Mechanical ventilation (MV) is associated with adverse outcomes in ventilated patients, and impact of MV-induced diaphragm changes are still unclear.
* How much thickness and strength variation can be expected in respiratory and limb muscles in critically ill patients undergoing prolonged MV? conditions: Critical Illness conditions: Muscle Weakness studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: Ultrasound name: Muscle strength measurement measure: Correlation between quadriceps strength and thickness measure: Quadriceps strength measure: Quadriceps thickness measure: Diaphragm thickness measure: Diaphragm strength measure: Time to reach the sitting position sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico status: RECRUITING city: Milan zip: 20122 country: Italy name: Veronica Rossi, MSc role: CONTACT email: veronica.rossi@policlinico.mi.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06289231 id: AWFiS/2023_5_PE briefTitle: The Use of Artificial Intelligence (AI) for Gait Analysis overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-07 date: 2024-08 date: 2024-03-01 date: 2024-03-04 name: Gdansk University of Physical Education and Sport class: OTHER briefSummary: The main purpose of this study will be to assess the consistency and reliability of measurements made using the Vicon three-plane gait analysis device (Vicon Motion Capture System Ltd, Oxford, UK) and a mobile application based on image recognition technology with the help of artificial intelligence. conditions: Gait studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED measure: Gait analysis by the Vicon system measure: Gait analysis by the mobile image recognition application sex: ALL minimumAge: 20 Years maximumAge: 25 Years stdAges: ADULT facility: Gdansk University of Physical Education and Sport city: Gdańsk state: Pomorskie zip: 80-336 country: Poland lat: 54.35205 lon: 18.64637 hasResults: False