hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06303986 id: NAS-002 briefTitle: Study to Collect Data for Neonatal Abstinence Syndrome (NAS) and Evaluate the Automated Data Collection Process overallStatus: RECRUITING date: 2024-03-18 date: 2024-06-30 date: 2024-06-30 date: 2024-03-12 date: 2024-03-22 name: Rekovar Inc. class: INDUSTRY name: Johns Hopkins University name: Children's Hospital of Orange County name: Children's Hospital Los Angeles name: University of New Mexico briefSummary: Substance abuse during pregnancy is on the rise through both prescribed and illicit use of controlled substances, which has increased neonatal abstinence syndrome (NAS). The prevalence of opioid use during pregnancy has increased by 333% from 2013 to 2014 and continues to rise. Approximately 1 in 3 women were prescribed opioids during pregnancy from 2008 to 2012. In the US, NAS was diagnosed every 25 minutes in 2014. By 2019, it became every 15 minutes. Although there are medication-based interventions for the treatment of NAS, used in up to 80% of opioid-exposed infants, these treatments carry risks of toxicity and drug interactions. Despite the steep medical costs and the risks of treatment, current tools to assess the severity of NAS are subjective and suffer from examiner bias, resulting in poorer clinical outcomes, such as longer lengths of stay in the Neonatal Intensive Care Unit (NICU), for these babies. Studies have shown that continuous vital sign monitoring improves outcomes and decreases the length of stay in general practice. Preliminary machine learning models have been able to predict pharmacological treatment for Neonatal Opioid Withdrawal Syndrome (NOWS). This project will collect physiological and behavioral data of NAS patients to develop an AI algorithm and establish the advantages of continuous monitoring in NAS. The AI algorithm, processed by machine learning, will help predict NAS symptoms, automate scoring, and provide healthcare personnel with predictive analytics to guide suggested treatments. conditions: Neonatal Abstinence Syndrome studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: Neomonki measure: Training/validation data collection measure: Continuous Monitoring sex: ALL maximumAge: 4 Weeks stdAges: CHILD facility: John Hopkins University status: RECRUITING city: Baltimore state: Maryland zip: 21224 country: United States name: Krystle McConnell, MPH role: CONTACT phone: 410-550-8779 email: kgreen39@jhmi.edu name: Lauren Jansson, MD role: PRINCIPAL_INVESTIGATOR lat: 39.29038 lon: -76.61219 facility: University of New Mexico status: RECRUITING city: Albuquerque state: New Mexico zip: 87106 country: United States name: Sandra S Beauman, MSN, RNC-NIC role: CONTACT phone: 505-272-0363 email: sbeauman@salud.unm.edu name: Jessie R Maxwell, MD, MBA role: PRINCIPAL_INVESTIGATOR lat: 35.08449 lon: -106.65114 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-03-23 uploadDate: 2024-02-26T15:29 filename: ICF_000.pdf size: 230657 hasResults: False
nctId: NCT06303973 id: IOE-PRS briefTitle: Effect of Oral Enteral Nutrition in Pierre Robin Syndrome overallStatus: COMPLETED date: 2022-01-10 date: 2023-06-02 date: 2023-06-15 date: 2024-03-12 date: 2024-03-12 name: Muhammad class: OTHER briefSummary: This was a randomized controlled study. The infants enrolled were randomly divided into the IOE group (with Intermittent Oro-Esophageal Tube Feeding, n=25) and the PNG group (with Nasogastric Tube Feeding, n=23), all receiving systemic therapy. Before and after 4-week treatment, pulmonary infection, swallowing function, nutritional status and body weight between the two group were compared. conditions: Pierre Robin Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 50 type: ACTUAL name: IOE name: PNG measure: Number of patients diagnosed as the pulmonary infection "Positive". measure: Nutritional status-total protein measure: Nutritional status-hemoglobin measure: Nutritional status-albumin measure: Nutritional status-prealbumin measure: Body weight measure: Swallowing function sex: ALL minimumAge: 1 Month maximumAge: 12 Months stdAges: CHILD facility: Renai Hospital city: Yilan country: Taiwan lat: 24.757 lon: 121.753 hasResults: False
nctId: NCT06303960 id: Cerebellar DBS for stroke briefTitle: Bilateral or Unilateral Cerebellar Deep Brain Stimulation for Chronic Post-stroke Motor Rehabilitation overallStatus: RECRUITING date: 2024-03-15 date: 2025-03-07 date: 2026-03-07 date: 2024-03-12 date: 2024-03-27 name: Qilu Hospital of Shandong University class: OTHER briefSummary: Upper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts.In this open-label, randomized phase I trial, we applied deep brain stimulation to the cerebellar dentate nucleus combined with bilateral or unilateral stimulation. We hypothesized that bilateral stimulation was superior to unilateral stimulation as the motor rehabilitation after stroke benefits from both side of cerebellum. conditions: Stroke studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Bilateral Cerebellar deep brain stimulation name: Unilateral Cerebellar deep brain stimulation measure: safety and feasibility of bilateral cerebellar DBS measure: FM-UE scores between bilateral and unilateral cerebellar DBS measure: Arm Motor Ability Test (AMAT) bilateral and unilateral cerebellar DBS measure: the Nine-Hole Peg Test between bilateral and unilateral cerebellar DBS measure: the Bilateral Box and Block Test between bilateral and unilateral cerebellar DBS measure: Short Form Health Survey (SF-12) between bilateral and unilateral cerebellar DBS measure: the EuroQol Five Dimensions Questionnaire (EQ-5D) between bilateral and unilateral cerebellar DBS measure: the Beck Depression Inventory or the Beck Anxiety Inventory between bilateral and unilateral cerebellar DBS measure: nerve conduction velocity between bilateral and unilateral cerebellar DBS sex: ALL minimumAge: 30 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chao Zhang status: RECRUITING city: Jinan state: Sichuan zip: 250100 country: China name: chao zhang role: CONTACT phone: +8613969007232 email: chao_zhang@sdu.edu.cn lat: 36.66833 lon: 116.99722 hasResults: False
nctId: NCT06303947 id: IOE-PKS briefTitle: Effect of Oral Enteral Nutrition Feeding in Parkinson Disease overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-07 date: 2024-07 date: 2024-03-12 date: 2024-03-15 name: Muhammad class: OTHER briefSummary: The goal of this or clinical trial is to explore Intermittent Oro-esophageal Tube Feeding vs. Nasogastric Tube Feeding on nutritional status, dysphagia, and activities of daily living in patients with Parkinson's disease. The main question it aims to answer are:
Participants will be divided into the control group and observation group evenly. All the patients were provided with routine therapy and given nutritional support by Intermittent Oro-esophageal Tube Feeding and Nasogastric Tube Feeding respectively. The nutritional status, swallowing function, and activities of daily living of the two groups of patients before and after treatment were evaluated. conditions: Parkinson Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Intermittent Oro-esophageal Tube name: Nasogastric tube name: Comprehensive rehabilitation training measure: Serum albumin level measure: Hemoglobin measure: Modified Barthel Index measure: Functional Oral Intake Scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06303934 id: IOE-NT briefTitle: Oral Enteral Nutrition in Infants With Cerebral Palsy and Dysphagia overallStatus: COMPLETED date: 2022-01-01 date: 2023-06-15 date: 2023-06-30 date: 2024-03-12 date: 2024-03-12 name: Muhammad class: OTHER briefSummary: This was a randomized controlled study including 80 infants with cerebral palsy and dysphagia. The Participants were evenly divided into the observation group (with intermittent oro-esophageal tube feeding, n=40) and the control group (with persistent nasogastric tube feeding , n=40). Nutritional status and physical development, condition of dysphagia, and pneumonia before and after 3-month treatment were compared. conditions: Cerebral Palsy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 80 type: ACTUAL name: systemic therapy name: Intermittent Oro-Esophageal Tube Feeding name: Persistent Nasogastric Tube Feeding measure: The Oral Motor Assessment Scale measure: Pneumonia measure: Hemoglobin measure: Total Protein measure: Albumin measure: Prealbumin measure: body weight measure: Penetration-Aspiration Scale measure: Functional Oral Intake Scale for Infants measure: Feeding amount sex: ALL minimumAge: 6 Months maximumAge: 12 Months stdAges: CHILD facility: River First Hos. city: Pingdong country: Taiwan lat: 24.46667 lon: 118.41667 hasResults: False
nctId: NCT06303921 id: 854681 briefTitle: Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503 overallStatus: RECRUITING date: 2024-02-16 date: 2029-02 date: 2029-02 date: 2024-03-12 date: 2024-04-25 name: University of Pennsylvania class: OTHER briefSummary: The current protocol is to determine the biodistribution, metabolism, excretion and brain uptake of 11C-M503. The goal of this radiotracer is to quantify alpha-synuclein that is abnormally deposited in the brain of people with Parkinson's disease (PD). Investigators will compare uptake in participants with PD versus participants with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), as well as non-Parkinsonism volunteers. This multicenter project funded by an NIH U19 grant, is centered at U Pennsylvania (Penn, Grant PI: Robert Mach) in collaboration with U Pittsburgh (Pitt) (non-clinical site) Yale U, U of California at San Francisco (UCSF) and Washington University in St. Louis (WU). The University of Pennsylvania will act as the sIRB for this multi-center human subjects project and participants will be recruited from all sites. conditions: Tauopathies studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 70 type: ESTIMATED name: 11C-M503 PET name: Brain MRI name: Amyloid PET name: Neurological assessments measure: Organ Biodistribution or Dosimetry measure: PET Uptake of Tracer measure: Adverse Events sex: ALL minimumAge: 40 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Pennsylvania status: RECRUITING city: Philadelphia state: Pennsylvania zip: 19104 country: United States name: Erin Schubert role: CONTACT phone: 215-662-3041 email: erinshu@pennmedicine.upenn.edu name: IIya Nasrallah, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 39.95233 lon: -75.16379 hasResults: False
nctId: NCT06303908 id: Commu-PKS briefTitle: How Traditional Chinese Medicine Exercise Improves Parkinson Disease overallStatus: NOT_YET_RECRUITING date: 2024-11 date: 2024-12 date: 2024-12 date: 2024-03-12 date: 2024-03-15 name: Muhammad class: OTHER briefSummary: The goal of this clinical trial is to explore the impact of Simple Gymnastics Training on Limb motor function and mental health in Parkinson's Patients in the Community (≥60 year old) with swallowing disorders. It primarily aims to address two key aspects: 1) the prevalence of Parkinson's Diseases among community-dwelling elderly individuals, and 2) the effects of Simple Gymnastics Training on Limb motor function and mental health in community-dwelling Parkinson's Patients. All patients are required to undergo a continuous three-week (21 days) Simple Gymnastics Training, with weekends off and training conducted only on weekdays. The training will be conducted two sessions per day, lasting 30 minutes each. conditions: Parkinson Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 300 type: ESTIMATED name: Simple Gymnastics Training measure: Unified Parkinson's Disease Rating Scale measure: The Berg Balance Scale measure: Patient Health Questionnaire-9 measure: Generalized Anxiety Disorder-7 sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06303895 id: Acu-PKS-new briefTitle: How Acupuncture Therapy Improves Dysphagia in Parkinson's Patients overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-06 date: 2024-06 date: 2024-03-12 date: 2024-03-13 name: Muhammad class: OTHER briefSummary: This study is focusing on dysphagic participants with Parkinson's disease. The aim of our study is to evaluate the effectiveness of acupuncture therapy as an additional intervention for these participants. Participants were randomly assigned to either the experimental group or the control group, with 56 individuals in each group. Both groups are receiving standard treatment and swallowing rehabilitation training, while the experimental group is also receiving acupuncture therapy. Our study aims to provide valuable insights into the potential benefits of acupuncture in improving swallowing difficulties in Parkinson's disease participants. conditions: Dysphagia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Routine rehabilitation training name: Swallowing rehabilitation training name: Acupuncture therapy measure: Penetration-Aspiration Scale-liquid measure: Penetration-Aspiration Scale-paste measure: Swallowing time measure: body mass index measure: Serum Albumin measure: Prealbumin measure: Hemoglobin measure: Swallowing Quality of Life sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06303882 id: AI-Dysphagia briefTitle: Effect of Computer-based Cognitive Function Training on Cognitive Dysphagia After Stroke overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-06 date: 2024-06 date: 2024-03-12 date: 2024-03-15 name: Muhammad class: OTHER briefSummary: This is a multicenter randomized controlled study. The study recruited stroke patients with mild cognitive impairment and dysphagia who were undergoing inpatient rehabilitation treatment in three hospitals in mainland China as the participants (study subjects). The study duration for each participant was 15 days. The subjects were randomly divided into an experimental group and a control group. During the treatment, all patients received routine rehabilitation treatment. In addition, patients in the control group received conventional cognitive training, while patients in the experimental group received computer-assisted cognitive training. conditions: Dysphagia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: routine rehabilitation treatment name: Computer-assisted Cognitive Function Training name: conventional cognitive training measure: Montreal Cognitive Assessment measure: The coordination of swallowing measure: Penetration-Aspiration Scale measure: Swallowing duration measure: Swallowing reflex sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06303869 id: STUDY22070043 briefTitle: Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2029-05 date: 2029-10 date: 2024-03-12 date: 2024-04-03 name: Jorge Gonzalez-Martinez class: OTHER briefSummary: The goal of this study is to verify whether the use of deep brain stimulation can improve motor function of the hand and arm and speech abilities for people following a stroke. Participants will undergo a surgical procedure to implant deep brain stimulation electrode leads. The electrodes will be connected to external stimulators and a series of experiments will be performed to identify the types of movements that the hand and arm can make and how speech abilities are affected by the stimulation. The implant will be removed after less than 30 days. Results of this study will provide the foundation for future studies evaluating the efficacy of a minimally-invasive neuro-technology that can be used in clinical neuro-rehabilitation programs to restore speech and upper limb motor functions in people with subcortical strokes, thereby increasing independence and quality of life. conditions: Stroke conditions: Brain Disease conditions: Central Nervous System Diseases conditions: Nervous System Diseases conditions: Cardiovascular Diseases studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Prospective, non-randomized, open-label, descriptive, experimental. primaryPurpose: BASIC_SCIENCE masking: NONE count: 10 type: ESTIMATED name: Deep Brain Stimulation (DBS) of the Motor Thalamus measure: Adverse Events measure: Discomfort and Pain measure: Dysphagia measure: Hand dexterity measure: Muscle weakness measure: Dexterity of Articulation AMRs measure: Dexterity of Articulation SMRs measure: Intelligibility of Speech measure: Spasticity measure: Range of Motion (ROM) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Pittsburgh city: Pittsburgh state: Pennsylvania zip: 15213 country: United States name: Cierra Clark, MS role: CONTACT phone: 240-441-4216 email: cic27@pitt.edu lat: 40.44062 lon: -79.99589 hasResults: False
nctId: NCT06303856 id: ABE-OLDer briefTitle: How Active Breathing Training Improves Dysphagia in Elderly People overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-05 date: 2024-05 date: 2024-03-12 date: 2024-03-13 name: Muhammad class: OTHER briefSummary: The goal of this clinical trial is to explore the impact of Active Breathing Exercises on swallowing function and quality of life in community-dwelling elderly individuals (≥60 year old) with swallowing disorders. It primarily aims to address two key aspects: 1) the prevalence of dysphagia among community-dwelling elderly individuals, and 2) the effects of Active Breathing Exercises on swallowing function and quality of life in community-dwelling elderly individuals with swallowing disorders. All participants enrolled are required to undergo a continuous three-week (21 days) Active Breathing Exercises, with weekends off and training conducted only on weekdays. The training will be conducted two sessions per day, lasting 15-30 minutes each. conditions: Dysphagia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 300 type: ESTIMATED name: Active Breathing Exercises measure: Eating Assessment Tool-10 measure: Time consumed in eating measure: Swallowing-Related Quality of Life Questionnaire sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06303843 id: 13.04.2023 briefTitle: The Effect of Electric Ride-On Cars Use During Transport to the Operating Theatre overallStatus: COMPLETED date: 2023-05-02 date: 2024-02-15 date: 2024-02-15 date: 2024-03-12 date: 2024-03-12 name: Uşak University class: OTHER briefSummary: The aim of our study was to evaluate the effect of the use of a electric ride-on car during transport to the operating theatre on preoperative anxiety in children undergoing elective ambulatory surgery. As a distraction method, children in the experimental group will be introduced to the operating theatre with a electric ride-on car. Yale Modified Preoperative Anxiety Scale Child Form will be used to evaluate anxiety. The sample size was determined as 118 as a result of power analysis. 59 children will be included in the experimental group and 59 children in the control group.
Translated with DeepL.com (free version) conditions: Anxiety conditions: Preoperative Anxiety conditions: Pediatric Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 118 type: ACTUAL name: Transfer with an electric ride-on car measure: Perioperative anxiety sex: ALL minimumAge: 2 Years maximumAge: 10 Years stdAges: CHILD facility: Usak University Training and Research Hospital city: Usak zip: 64100 country: Turkey lat: 38.67351 lon: 29.4058 hasResults: False
nctId: NCT06303830 id: BACA2019 briefTitle: Bariatric Surgery and Cardiovascular Responses to Sodium Nitrate overallStatus: COMPLETED date: 2019-04-16 date: 2020-12-17 date: 2021-10-01 date: 2024-03-12 date: 2024-03-12 name: University of Sao Paulo class: OTHER briefSummary: Inorganic nitrite and nitrate can be reduced to NO and NO-related species such as S-nitrosothiols via the nitrate-nitrite-NO pathway. This is due to the reduction of nitrate to nitrite by the action of bacteria in the mouth and the reduction of nitrite to NO depending on the acidic pH on the stomach or by enzymes with nitrite-reductase activity. The acidic environment of the stomach is very important to the formation of NO and S-nitrosothiols and several studies suggest that changes in gastric pH can affect this conversion. In this context, bariatric surgery, by altering the anatomy of the stomach and increasing gastric pH, can affect the nitrate-nitrite-NO pathway and change the antihypertensive and antioxidant effect of sodium nitrate. conditions: Hypertension studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 30 type: ACTUAL name: Sodium nitrate measure: Assess changes in s-nitrosothiols measure: Assess changes in blood pressure measure: Assess changes in endotelial function measure: Assess changes in Vascular stiffness measure: Assess changes in nitrate concentration measure: Assess changes in nitrite concentration sex: FEMALE minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Usp - Hospital Das Clínicas Da Faculdade de Medicina de Ribeirão city: Ribeirão Preto state: São Paulo zip: 14.048-900 country: Brazil lat: -21.1775 lon: -47.81028 hasResults: False
nctId: NCT06303804 id: HSC-SPH-23-0837 briefTitle: Prevention of Opioid Misuse and Overdose Deaths Among Hispanic/Latinx Adolescents: A Family-based Perspective overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-08-31 date: 2024-08-31 date: 2024-03-12 date: 2024-03-12 name: The University of Texas Health Science Center, Houston class: OTHER briefSummary: The purpose of this study is to develop culturally-competent family-focused educational modules targeting opioid knowledge and attitudes (including targeting safe storage and prevention of accidental opioid overdose in adolescent populations) and examine changes acceptability, knowledge, and attitudes scores conditions: Opioid Misuse studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 50 type: ESTIMATED name: Educational videos measure: Acceptability of the educational materials presented via the educational videos, including cultural congruence as assessed by a questionnaire measure: Changes in opioid related knowledge as assessed by a questionnaire sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The University of Texas Health Science Center at Houston city: Houston state: Texas zip: 77030 country: United States name: Alejandra Fernandez, PhD role: CONTACT phone: 972-546-2920 email: Alejandra.Fernandez@uth.tmc.edu lat: 29.76328 lon: -95.36327 hasResults: False