Therefore, this study aims to evaluate the appearance of symptoms compatible with an acute attack of FMF following the ingestion of wheat or other foods, and the prevalence of self-perceived gluten/wheat sensitivity in patients with FMF. conditions: Familial Mediterranean Fever conditions: Non-celiac Gluten Sensitivity studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: Main questionnaire name: Secondary questionnaire measure: Prevalence of the self-perception of wheat as a potential trigger of acute attack in patients with familial Mediterranean fever (FMF) measure: Prevalence of the self-perception of other foods, other than wheat, as potential triggers of an acute attack in patients with FMF measure: Prevalence of self-reported NCGS/NCWS in patients with FMF measure: Genetic differences between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Genetic differences between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Genetic differences between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Ethnic group differences between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Ethnic group differences between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Ethnic group differences between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Education level differences between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Education level differences between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Education level differences between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Working activity differences between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Working activity differences between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Working activity differences between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Gastrointestinal symptoms differences between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Gastrointestinal symptoms differences between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Gastrointestinal symptoms differences between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Extraintestinal symptoms differences between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Extraintestinal symptoms differences between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Extraintestinal symptoms differences between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Extraintestinal symptoms duration differences between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Extraintestinal symptoms duration differences between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Extraintestinal symptoms duration between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Gastrointestinal symptoms duration differences between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Gastrointestinal symptoms duration differences between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Gastrointestinal symptoms duration differences between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: FMF specific drugs intake differences between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: FMF specific drugs intake differences between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: FMF specific drugs intake differences between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Differences in number/year of FMF attacks between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Differences in number/year of FMF attacks between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Differences in number/year of FMF attacks between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Differences in FMF specific drugs intake adherence between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Differences in FMF specific drugs intake adherence between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Differences in FMF specific drugs intake adherence between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Differences in marital status between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Differences in marital status between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Differences in marital status between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Differences in age at FMF diagnosis between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Differences in age at FMF diagnosis between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Differences in age at FMF diagnosis between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. measure: Differences in age at FMF symptom's onset between FMF patients who perceive a trigger effect of wheat and those who do not identify this specific food as a potential trigger of the disease flares. measure: Differences in age at FMF symptom's onset between FMF patients who perceive a trigger effect of foods other than wheat and those who do not identify foods other than wheat as a potential trigger of disease flares. measure: Differences in age at FMF symptom's onset between patients with FMF who self-report NCGS/NCWS and those who do not self-report it. sex: ALL minimumAge: 6 Months maximumAge: 80 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital of Palermo status: RECRUITING city: Palermo state: Sicily zip: 90127 country: Italy name: Pasquale Mansueto role: CONTACT phone: 00390916554815 email: pasquale.mansueto@unipa.it name: Pasquale Mansueto role: PRINCIPAL_INVESTIGATOR name: Antonio Carroccio role: SUB_INVESTIGATOR name: Aurelio Seidita role: SUB_INVESTIGATOR lat: 38.13205 lon: 13.33561 hasResults: False