hackint0sh/New-Dataset huggingface dataset:
Researchers will compare a group of low back pain patients to an age-, gender- and anthropometrics-matched control group of pain-free subjects to see if exercise-induced hypoalgesia is also observed when there is no low back pain diagnosis. conditions: Low Back Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 76 type: ESTIMATED name: Isometric exercise name: Aerobic exercise name: Placebo intervention measure: Pain intensity measure: Pain-pressure thresholds measure: Trunk flexion-extension electromyography (EMG) measure: Flexion-extension ratio (EMG) measure: Maximum ranges of lumbar and pelvic flexion measure: Trunk flexion-extension percentages of motion measure: Time of maximum flexion measure: Fear-avoidance beliefs measure: Pain distribution and supra-threshold stimulation measure: Anthropometric data: height measure: Anthropometric data: weight measure: Date of birth/ age measure: Sex/ gender measure: Basic clinical history and occupational data sex: ALL minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT facility: Clinical Anatomy of the Musculoskeletal System Laboratory. Department of Anatomy and Human Embryology, School of Medicine, Universitat de València status: RECRUITING city: Valencia zip: 46010 country: Spain name: Daniel Sánchez-Zuriaga, PhD, MD role: CONTACT phone: +343983522 phoneExt: 83522 email: daniel.sanchez@uv.es lat: 39.46975 lon: -0.37739 hasResults: False
nctId: NCT06330948 id: NYCU112183AEF briefTitle: Effects of SugarCut® Unripe Guava Fruit Extract on Blood Glucose Regulation overallStatus: RECRUITING date: 2024-04 date: 2025-01 date: 2025-01 date: 2024-03-26 date: 2024-04-15 name: National Yang Ming University class: OTHER briefSummary: Guava (Psidium guajava) belongs to the Myrtle family. It is a tropical and subtropical fruit native to the Americas. Ripe guava fruit is sweet and delicious. It is rich in vitamins A, C and trace elements such as phosphorus, calcium and magnesium. In traditional medicine, guava fruit can be eaten raw, and the roots can treat stomach problems, abdominal pain, dysentery, and diabetes; the leaves can treat diabetes, abdominal pain, rheumatism, antipyretic, stomachache, anthelmintic, cholera, vomiting, diarrhea, enteritis and other symptoms. Guava leaf extract contains polyphenols. Studies have shown that guava leaf has antioxidant, blood sugar regulating and anti-cancer effects. Not only guava leaves, research has found that guava fruits are rich in vitamins, fiber and antioxidants, which have anti-inflammatory and anti-cancer effects. Preliminary research has found that the extract of red guava young fruit has more active ingredients - saponins and total polyphenol content, and its antioxidant capacity is also higher than that of mature guava. In vitro studies have found that guava fruit extract can increase the expression of GLUT4 gene and promote the entry of blood sugar into cells. At the same time, guava fruit extract can inhibit the formation of final glycated proteins (AGEs). The purpose of this study is to explore the effect of guava fruit extract on blood sugar regulation in humans and to evaluate its potential to be developed as a blood sugar regulation supplement. conditions: PreDiabetes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: SugarCut® Unripe Guava Fruit Extract name: Placebo group measure: GLUT4 gene expression measure: Hematology Test sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: National Yang Ming Chiao Tung University status: RECRUITING city: Taipei state: Beitou Dist. zip: 112 country: Taiwan name: Tze-Fang Wang, Ph.D. role: CONTACT phone: +886-2-28267907 email: tzefang@nycu.edu.tw lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06330935 id: 192-2023 briefTitle: Evaluating the Effect of Tranexamic Acid on the Clinical Outcomes in Patients With Traumatic Brain Injury overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-03 date: 2025-03 date: 2024-03-26 date: 2024-03-26 name: Mansoura University class: OTHER briefSummary: Evaluate the effect of tranexamic acid on mortality in pediatric patients with traumatic brain injury. This could potentially lead to improved treatment protocols and better outcomes for this vulnerable population. conditions: Traumatic Brain Injury studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 90 type: ESTIMATED name: Tranexamic Acid (TXA) name: Normal saline measure: The early traumatic brain injury-related death in the hospital measure: The difference between treatment group in the Intracranial haemorrhage growth measure: The difference between the treatment groups in the incidence of mortality measure: Need for neurosurgical management measure: Days in the intensive care unit measure: Need for blood transfusion measure: Adverse events measure: Pediatric Quality of Life (PedsQL) measure: Pediatric Glasgow Outcome Scale Extended (GOS-E) Peds) sex: ALL minimumAge: 1 Month maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06330922 id: 10.55776/V992 briefTitle: Muscle-tendon Pathology and Metabolic Dysregulation in CP overallStatus: RECRUITING date: 2024-03-08 date: 2025-12-31 date: 2025-12-31 date: 2024-03-26 date: 2024-03-26 name: University of Graz class: OTHER name: Medical University of Graz name: Karolinska Institutet briefSummary: The main aim of this project is to gain knowledge about the muscle-tendon pathology of moderately to severely affected young people with cerebral palsy and their risk for cardiometabolic diseases and chronic inflammation. Furthermore, it will be investigated whether there are associations between the existing pathophysiology as well as inactivity and muscle function, cardiometabolic risk factors and inflammation. Moreover, the potential of the target group for adaptation of its muscular, cardiorespiratory, and endocrine system will be investigated.
To measure the study parameters, ultrasound, strength tests, near-infrared spectroscopy, blood analyses, and spiroergometry will be used. The fitness training will be performed two times a week for 12 weeks with the Frame Runners. conditions: Cerebral Palsy, Spastic studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 50 type: ESTIMATED name: Cardiorespiratory fitness training measure: Muscle fascicle length and muscle thickness measure: Muscle fascicle pennation angle measure: Passive muscle stiffness measure: Isometric muscle strength measure: Muscle tissue oxygenation measure: Exosome size measure: Exosome content measure: Micro ribonucleic acid (RNA) cargo measure: Metabolic parameters measure: Pro-inflammatory cytokines measure: Resting, mean, and peak heart rate measure: Resting blood pressure measure: Distance covered measure: Peak oxygen uptake (VO2peak), Peak ventilation (VEpeak) measure: Peak respiratory frequency measure: Respiratory exchange ratio measure: VEpeak/VO2peak measure: VEpeak/VCO2peak measure: Perceived exertion measure: Well-being and quality of life measure: Total physical activity, time spent in different intensities measure: Passive range of motion (sagittal plane) of hip, knees, ankles measure: Step count measure: Body height measure: Body weight measure: Body mass index (BMI) measure: Modified Ashworth Scale Score of the Plantar flexors sex: ALL minimumAge: 14 Years maximumAge: 25 Years stdAges: CHILD stdAges: ADULT facility: Institute of Human Movement Science, Sport and Health, University of Graz status: RECRUITING city: Graz zip: 8010 country: Austria name: Sebastian Ruin, Univ.-Prof. role: CONTACT phone: 00433163802336 email: sebastian.ruin@uni-graz.at lat: 47.06667 lon: 15.45 hasResults: False
nctId: NCT06330909 id: P003103 id: DRKS00022915 type: OTHER domain: Deutsches Register Klinische Studien briefTitle: Image-guided Focal Dose Escalation- Primary pc Treated With Primary External Beam Hypofract.Stereotactic rt acronym: HypoF-SBRT overallStatus: RECRUITING date: 2022-08-18 date: 2025-08 date: 2030-02 date: 2024-03-26 date: 2024-03-26 name: University Hospital Freiburg class: OTHER name: German Federal Ministry of Education and Research briefSummary: Technical advances in radiotherapy (RT) treatment planning and delivery have substantially changed RT concepts for primary prostate cancer (PCa) by (i) enabling a reduction of treatment time and by (ii) enabling a safe delivery of high RT doses. Several studies proposed a dose-response relationship for patients with primary prostate cancer (PCa) and especially in patients with high-risk features a dose escalation should lead to improved tumor control. In parallel to the improvements in RT techniques, diagnostic imaging techniques like multiparametric magnetic resonance imaging (mpMRI) and positron-emission tomography (PET) evolved and enable an accurate depiction of the intraprostatic tumor mass for the first time. The HypoFocal-SBRT study combines ultra-hypofractionated RT / stereotactic body RT (reduction of treatment time) with a focal RT dose escalation on intraprostatic tumor sides by applying state of the art diagnostic imaging and most modern RT concepts. This novel concept will be compared with moderate hypofractionated RT (MHRT), one option for the curative primary treatment of PCa, which has been proven by several prospective trials and is recommended and carried out worldwide. We suspect an increase in relapse-free survival (RFS) and we will also assess quality of life in order to detect potential changes. conditions: Prostate Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a prospective, randomized two arm phase III multicentre trial comparing image-guided focal dose escalation using SBRT in patients with primary PCa treated with primary external beam hypofractionated radiation therapy.
Patients will be randomized to either arm A (experimental intervention) or arm B (control intervention). primaryPurpose: TREATMENT masking: NONE count: 374 type: ESTIMATED name: Radiotherapy (RT) Arm A - IMRT/IGRT/SBRT name: Radiotherapy (RT) Arm B - IMRT/IGRT measure: Relapse free survival measure: Time to local failure after randomization measure: Metastatic free survival after randomization measure: Overall (OS) and prostate cancer specific (PCSS) survival after randomization measure: Time to biochemical failure (phoenix definition) after randomization measure: Patient reported acute quality of life (QOL) - Expanded Prostate Index Composite-26 (EPIC-26) measure: Patient reported late quality of life (QOL) measure: Cumulative acute GU and GI toxicities during and up to 3 months after RT using the CTCAEv5.0 criteria measure: Cumulative Chronic GU and GI toxicities after RT using the CTCAEv5.0 criteria measure: Dose constraints and prescription doses / recruited patients measure: Characterization of safety: adverse events sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Medical Center - University of Freiburg status: RECRUITING city: Freiburg state: Baden-Württemberg zip: 79106 country: Germany lat: 47.9959 lon: 7.85222 hasResults: False
nctId: NCT06330896 id: 346/2566(IRB3) briefTitle: Disease Characteristics and Treatment Response in Plasma Cell Disorders Patients Based on Genetic Abnormalities From Fluorescence In Situ Hybridization and Next Generation Sequencing acronym: genetics MM overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-09-30 date: 2028-04-01 date: 2024-03-26 date: 2024-03-26 name: Siriraj Hospital class: OTHER briefSummary: The goal of this observational study is to study the genetic landscape in patients with Plasma Cell Disorders including MGUS, SMM, MM, and amyloidosis in Thailand. The main questions it aims to answer are:
The FISH and/or NGS testing results, disease characteristics, treatment, and treatment outcomes of patients with plasma cell disorders who underwent FISH and/or NGS testing before IRB approval will be collected through retrospective chart review. Subsequently, data will be gathered prospectively. Participants will provide approximately 12 mL of bone marrow fluid for FISH and NGS testing. conditions: Plasma Cell Disorder studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 498 type: ESTIMATED measure: genetic landscape of PCD measure: genetic correlation measure: genetic landscape of relapse MM patients measure: overall survival measure: progression free survival measure: factor of genetic landscape differentiation measure: gender measure: age sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06330883 id: 2021/507 briefTitle: Determining the Prevalence of Frailty and Evaluating Its Relationship With Mortality. overallStatus: COMPLETED date: 2022-01-01 date: 2023-01-01 date: 2023-01-01 date: 2024-03-26 date: 2024-03-26 name: Selcuk University class: OTHER briefSummary: Covid-19 patients admitted to the intensive care unit of Selcuk University Hospital were included in the study. Clinical frailty score was given during admission to the intensive care unit. Demographic data, laboratory data, radiological imaging and vital signs of the patients were recorded. Treatment and patient positions were recorded during the intensive care follow-up of the patients. Mortality status of the patients 6 months after admission to the ICU was recorded. conditions: Frailty conditions: Mortality conditions: COVID-19 studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 148 type: ACTUAL name: Prognosis measure: Mortality measure: The Sequential Organ Failure Assessment Score, The Acute Physiology and Chronic Health Evaluation II Score measure: Thorax computed tomography (CT) imaging measure: Laboratory values measure: Respiratory support measure: Vasoactive drugs administered measure: Renal replacement therapy measure: Patient positions measure: Length of stay in the intensive care unit sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Selcuk University Hospital city: Konya state: Selçuklu country: Turkey lat: 37.87135 lon: 32.48464 hasResults: False
nctId: NCT06330870 id: BCBM_Breast briefTitle: Brain Metastasis Development Mechanism in BCBM Patients overallStatus: RECRUITING date: 2023-04-06 date: 2025-02-05 date: 2027-12-31 date: 2024-03-26 date: 2024-03-26 name: Samsung Medical Center class: OTHER briefSummary: This study is the experimental study for brain metastasis development mechanism in patients with breast cancer with brain metastasis conditions: Breast Cancer conditions: Brain Metastasis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 30 type: ESTIMATED name: WGS/TME evaluation measure: Intracranial disease free survival sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Ji-Yeon Kim status: RECRUITING city: Seoul zip: 06351 country: Korea, Republic of name: Ji-Yeon Kim role: CONTACT lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06330857 id: Dnr2021-06921-02 briefTitle: Recurrence and Bowel Function After Laparoscopic Vaginorectopexy, a Modified Anterior Rectopexy overallStatus: ACTIVE_NOT_RECRUITING date: 2002-05-28 date: 2024-04-01 date: 2025-04-01 date: 2024-03-26 date: 2024-04-17 name: Sahlgrenska University Hospital, Sweden class: OTHER briefSummary: Several pelvic prolapses can render defecation difficulties and they are often treated with different surgical techniques. This study will evaluate a novel variation of a laparoscopic technique used to treat rectal prolapse that is modified to treat multiple pelvic prolapses. 25 women with symptoms of obstructed defecation and multiple pelvic prolapses are assessed before and after surgery with clinical examination, defecography and a questionnaire for bowel function and quality of life. Follow up was scheduled after three and twelve months and at long term (minimum ten years). conditions: Rectal Prolapse conditions: Fecal Incontinence conditions: Defecation Disorder conditions: Enterocele conditions: Rectocele studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Evaluation of recurrence with clinical examination and defecography. Evaluation of bowel function with a questionnaire. primaryPurpose: TREATMENT masking: NONE count: 25 type: ACTUAL name: Laparoscopic vaginorectopexy measure: Recurrence measure: Bowel function measure: Bowel related quality of life measure: Postoperative complications measure: Peroperative complications measure: Operative time measure: Conversions to open surgery measure: Hospital days sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06330844 id: RBSEF-MCI-CCT briefTitle: Race-Based Stress and Cognitive Training for MCI overallStatus: NOT_YET_RECRUITING date: 2024-06-15 date: 2026-09-15 date: 2027-03-15 date: 2024-03-26 date: 2024-03-26 name: Rosalind Franklin University of Medicine and Science class: OTHER briefSummary: This a two phase project that aims to pilot a new adaptation (Phase 1) of Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT; an originally VA-based cognitive rehabilitation manualized intervention for older adults with MCI, with a focus on the impact of stress on cognitive functioning; that integrates components from the Race Based Stress and Empowerment (RBSE) group for an increased focus on race-based stress and discrimination for racial minority older adults (i.e., RBSEF-CCT-MCI). In a pilot open trial, 75-150 participants will receive group-based intervention for 8 weeks, with 8-10 participants per group.
Following the pilot study, the investigators will complete a randomized controlled trial (RCT) (Phase 2) to compare the efficacy of the RBSEF-CCT-MCI with the ME-CCT. In the RCT, 75-150 participants will be randomized into either 1) The active control group, who will complete the original, ME-CCT training program, or 2) The experimental group, who will complete the newly developed RBSE-CCT-MCI. Both research groups will complete the interventions for 8 weeks, with 8-10 participants per group.
Hypothesis: Participation in this newly developed/updated intervention (i.e., RBSEF-CCT-MCI) will result in improvements in both (a) subjective and (b) objective cognitive functioning, and (c) self-reported mental health symptoms. conditions: Mild Cognitive Impairment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two groups assignment - One group will complete the original ME-CCT training program. The other group will complete the newly developed RBSE-CCT-MCI. primaryPurpose: TREATMENT masking: NONE count: 9 type: ESTIMATED name: Race Based Stress and Empowerment Focused Compensatory Cognitive Training for Mild Cognitive Impairment (RBSEF-CCT-MCI) name: Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT) measure: Verbal learning and memory measure: Basic auditory attention and working memory measure: Psychomotor processing speed measure: Psychomotor processing speed; executive functioning measure: Self-report of prospective and retrospective memory measure: Self-report of cognitive concerns measure: The Patient Health Questionnaire-9 measure: Self-report symptoms of anxiety measure: Self-reported daily functioning measure: The Racial Microaggressions Scale measure: The Trauma Symptoms of Discrimination Scale sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Rosalind Franklin University of Medicine and Science city: Chicago state: Illinois zip: 60064 country: United States name: Rachael Ellison, PhD role: CONTACT name: Rachael Ellison, PhD role: PRINCIPAL_INVESTIGATOR lat: 41.85003 lon: -87.65005 hasResults: False
nctId: NCT06330831 id: x2ghr8pc briefTitle: Intensive Group Based CIMT for Young Children overallStatus: COMPLETED date: 2016-05-09 date: 2023-06-28 date: 2023-07-01 date: 2024-03-26 date: 2024-03-26 name: Rockhurst University class: OTHER name: Ability KC briefSummary: This project aims to investigate the effectiveness of an intensive, group-based Constraint Induced Movement Therapy (CIMT) program for young children ages 2-6 years with unilateral hemiparesis, or weakness on one side of the body. This project involves two studies. Study 1 investigates the effect of one dosage of a 1-month, intensive group based CIMT summer program. Study 2 investigates the effect of a repeated, consecutive episode of the intensive, group based CIMT program for children who attended the program the following summer. conditions: Hemiplegic Cerebral Palsy conditions: Non-Accidental Traumatic Head Injury to Child studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Study 1 is a single group pre-post study of children who received 1 episode of the intensive, group based CIMT intervention (2 data points- pre CIMT 1 and post CIMT1). Study 2 is a repeated measures design to evaluate the long-term effects of the first episode and the effects of the second episode of intensive group based CIMT (4 data points- pre CIMT1; post CIMT1 (at the end of 1 month intervention); pre CIMT 2- 11 months after post of CIMT1; post CIMT 2- 12 months post CIMT 1) primaryPurpose: TREATMENT masking: NONE maskingDescription: No masking occurred for the participants or care providers since all parents/caregivers consented to have their children participate in the intensive group based CIMT intervention. The parents/ care providers knew who the interventionists were. The principal investigator was aware of all participants' assignment to the study. The principal investigator also delivered the intervention to the 2-3-year-old group and also served as the assessor of outcomes along with trained student investigators. The principal investigator attempted to limit bias by having all students achieve an inter-rater reliability level of 90% or above (intra-class correlation coefficient ICC\>.90) on the QUEST and by not allowing the student investigators or herself to consult the pre-intervention assessment outcome scores until after post-intervention outcome assessment scoring was completed. count: 35 type: ACTUAL name: Intensive, Group Based Constraint Induced Therapy (CIMT) measure: Quality Upper Extremity Skills Evaluation Test (QUEST) measure: Assisting Hand Assessment (AHA) measure: Canadian Occupational Performance Measure (COPM) measure: Pediatric Evaluation Disability Inventory (PEDI) sex: ALL minimumAge: 20 Months maximumAge: 6 Years stdAges: CHILD hasResults: False
nctId: NCT06330818 id: IMAGINE Moyamoya id: 528291394 type: OTHER_GRANT domain: German Research Council (DFG) briefTitle: Imaging in Moyamoya Disease - Study to Investigate Different Imaging Technologies for a Better Understanding of Various Imaging Techniques to Evaluate Cerebral Hemodynamics, Disease-activity and Possibly the Etiology in Moyamoya Patients acronym: IMAGINE overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05-30 date: 2027-05-30 date: 2024-03-26 date: 2024-03-26 name: University Hospital Tuebingen class: OTHER name: University Hospital Freiburg briefSummary: Aim of this study is to improve patient care in Moyamoya Patients by improving Imaging technologies and aiming to identify factors involved in disease progression.