hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06316414 id: 1501/17 briefTitle: Omalizumab in Severe Asthmatics With Food Allergy acronym: OSAFA overallStatus: COMPLETED date: 2018-01-01 date: 2023-03-31 date: 2023-03-31 date: 2024-03-18 date: 2024-03-18 name: Bambino Gesù Hospital and Research Institute class: OTHER briefSummary: A prospective assessment of the impact of Omalizumab in terms of efficacy, safety, and quality of life (FA-QoL) in patients with moderate/severe asthma and history of anaphylaxis to peanut, tree nuts, fish, egg, milk, and/or wheat. Evaluation of the trend of total and specific IgE during Omalizumab treatment. conditions: Food; Allergy, Anaphylactic Shock conditions: Asthma in Children studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 65 type: ACTUAL name: Omalizumab measure: Milligram tolerated food allergen (gms) of raw and baked milk, raw and baked egg, hazelnut, peanut, wheat, and/or fish at T1. measure: Proportion of negative OFCs at T1 measure: NOAEL for raw and baked milk, raw and baked egg, hazelnut, peanut, wheat, and/or fish at T2. measure: NOAEL for raw and baked milk, raw and baked egg, hazelnut, peanut, wheat, and/or fish at T3. measure: Change in number of anaphylactic events measure: Rate of severity of anaphylactic events measure: Asthma Control Test (ACT) measure: Quality of Life score measure: Total IgE measure: Specific IgE for milk, egg, hazelnut, peanut, wheat, and/or fish sex: ALL minimumAge: 6 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Pediatric Hospital Bambino Gesù IRCCS - Allergy Dpt city: Roma zip: 00145 country: Italy lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06316401 id: 03-2024 briefTitle: Endoscopic Submucosal Dissection of Large Recto-sigmoid Lesions Under Spinal Anesthesia overallStatus: COMPLETED date: 2021-01-01 date: 2023-01-31 date: 2024-03-03 date: 2024-03-18 date: 2024-03-18 name: Azienda USL Modena class: OTHER briefSummary: The investigators collected data on all consecutive patients who underwent ESD for recto-sigmoid laterally spreading tumors (LSTs) \>35 mm under SA between January 2021 and March 2024. The investigators evaluated the technical success and safety of SA in terms of ARAEs, and pain, measured via visual assessment scale (VAS). conditions: Colorectal (Colon or Rectal) Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 20 type: ACTUAL name: ESD of large LSTs under SA measure: Technical success of ESD under SA measure: Safety of ESD under SA measure: Intra- and post-procedural need for additional opioid or other analgesic drug administration measure: ESD- and colonoscopy-related AEs measure: Length of hospital stay measure: Median ESD duration sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mauro Manno city: Carpi state: MO zip: 41012 country: Italy lat: 44.78237 lon: 10.8777 hasResults: False
nctId: NCT06316388 id: TDME briefTitle: Outcomes After Vitrectomy in Eyes With Tractional Diabetic Macular Edema overallStatus: NOT_YET_RECRUITING date: 2024-03-10 date: 2025-03-10 date: 2025-03-11 date: 2024-03-18 date: 2024-03-18 name: Rehab Azzam class: OTHER briefSummary: 1. assessment the outcomes of vitrectomy on retinal function by mf-ERG (multifocal electroretinogram) and anatomy by OCT (optical coherence tomography) in patients with tractional diabetic macular edema (TDME) .
2. To correlate the postoperative corrected distance visual acuity (CDVA) with the mf-ERG and OCT findings following vitrectomy surgery for TDME. conditions: Diabetic Macular Edema studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 21 type: ESTIMATED name: vitrectomy measure: assessment the outcomes of vitrectomy on retinal function in patients with tractional diabetic macular edema measure: assessment the outcomes of vitrectomy on retinal anatomy in patients with tractional diabetic macular edema measure: correlation CDVA with mf-ERG and OCT finding sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06316375 id: STUMBL blunt chest trauma briefTitle: STUMBL Score as a Risk Stratification Tool for Management of Blunt Chest Trauma Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-03-31 date: 2026-04-30 date: 2024-03-18 date: 2024-03-27 name: Assiut University class: OTHER briefSummary: The aim of this study is to assess validity of the STUMBL score in EGYPT for complications of blunt chest trauma without multi-trauma and immediate life-threatening injuries and identify patients at risk of in- hospital mortality or ICU admission and predict survival in both Assiut \& Suez Canal University Hospitals. conditions: Blunt Injury of Thorax studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: The primary outcome was to assess the validity of the STUMBL score for all complications of chest blunt trauma, originally defined by the STUMBL authors measure: Secondary outcomes validated the STUMBL score using a composite of early and delayed complications. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06316362 id: SMOF in carbamazepine toxicity briefTitle: Efficacy of SMOF Lipid in the Management of Acute Poisoning With Carbamazepine overallStatus: COMPLETED date: 2022-01-01 date: 2023-02-01 date: 2023-02-28 date: 2024-03-18 date: 2024-03-18 name: Alexandria University class: OTHER briefSummary: The goal of the current study was to evaluate whether SMOF lipid administration could be used as an adjuvant therapy to treat acute, moderate-to-severe carbamazepine poisoning. conditions: Acute Poisoning studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 40 type: ACTUAL name: SMOF lipid 20% measure: Improvement in Conscious Levels Measured by Glasgow Coma Scale (GCS) measure: Assessment of Intubation Requirement Using GCS and APACHE measure: Length of Intensive Care Unit (ICU) Stay measure: length of hospital stay sex: ALL minimumAge: 18 Years maximumAge: 54 Years stdAges: ADULT facility: Faculty of Medicine city: Alexandria country: Egypt lat: 31.21564 lon: 29.95527 hasResults: False
nctId: NCT06316349 id: CAAE: 75727323.3.0000.0068 briefTitle: Isolated Resistance Training and Neuromuscular Electrical Stimulation in Patients With Femoral Intra Aortic Balloon Pump. overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2025-01-10 date: 2025-10-01 date: 2024-03-18 date: 2024-03-19 name: University of Sao Paulo General Hospital class: OTHER briefSummary: The objective of this randomized clinical trial is to compare the effects of a standardized exercise program alone versus the same program combined with neuromuscular electrical stimulation in patients undergoing heart failure . The main questions it aims to answer are:
* Evaluating the changes in the chronaxie of the rectus femoris muscle in both lower limbs The protocol will have a total duration of 35 days, with an initial intervention period of 21 days (5 days per week), followed by a 14-day follow-up period. conditions: Heart Failure conditions: Physical Therapy conditions: Neuromuscular Electrical Stimulation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Rondomized controlled trial primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The researcher responsible for conducting the ultrasonographic measurements will be blinded regarding the randomization and allocation groups. whoMasked: OUTCOMES_ASSESSOR count: 68 type: ESTIMATED name: Isolated Resistance Training Program name: Neuromuscular electrical stimulation measure: To investigate echo intensity of the rectus femoris muscle measure: To investigate cross-sectional area of the rectus femoris muscle measure: To investigate pennation angle of the rectus femoris muscle measure: To investigate changes in quadriceps femoral muscle strength measure: To investigate changes in arterial blood pressure during the protocol measure: To investigate changes in heart rate during the protocol measure: To investigate changes in peripheral oxygen saturation during the protocol measure: To investigate changes in the veno-arterial difference in carbon dioxide partial pressure sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Instituto do Coração - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo city: Sao Paulo zip: 05403-000 country: Brazil name: Silvia HG Lage, MD,PhD role: SUB_INVESTIGATOR name: Kelly CO Abud, PT,PhD role: SUB_INVESTIGATOR lat: -23.5475 lon: -46.63611 hasResults: False
nctId: NCT06316336 id: BE24-005 briefTitle: Multiple Dose, Bioequivalence Study of Generic Alfuzosin Hydrochloride 10 mg Prolonged-release Tablets Under Fed Conditions acronym: BE24-005 overallStatus: NOT_YET_RECRUITING date: 2024-06-10 date: 2024-06-22 date: 2024-06-28 date: 2024-03-18 date: 2024-03-18 name: Pharma Nueva class: INDUSTRY briefSummary: Objectives:
An open label, randomized, two-treatment, two-period, two-sequence, multiple oral dose, crossover bioequivalence study in healthy Thai male volunteers under fed conditions with at least 7 days washout period between last dosing of Period 1 and first dosing of Period 2. conditions: Healthy Vollunteer studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 44 type: ESTIMATED name: Alfuzosin Hydrochloride 10 mg name: Xatral® XL 10 mg measure: Plasma area Under the Curve (AUC(Day 6 and Day 7)) for Alfuzosin Hydrochloride 10 mg Prolonged-release Tablets measure: Peak Plasma Concentration (Cmax) of Alfuzosin Hydrochloride 10 mg Prolonged-release Tablets sex: MALE minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT hasResults: False
nctId: NCT06316310 id: XSF20240312 briefTitle: Effect of Acupoint Thread Embedding on Obesity overallStatus: RECRUITING date: 2024-03-15 date: 2025-12-31 date: 2026-12-31 date: 2024-03-18 date: 2024-03-19 name: Shanghai Municipal Hospital of Traditional Chinese Medicine class: OTHER briefSummary: The investigators describe a protocol for a randomized controlled trial to find out the effect and safety of acupoint thread embedding on losing weight in obese patients. conditions: Obesity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: All eligible participants will be randomly assigned into two group at a ratio of 1:1, the Acupoint Thread Embedding group and the Sham Acupoint Thread Embedding group (the control group).
group). primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 110 type: ESTIMATED name: acupoint thread embedding measure: Body Mass Index (BMI) measure: Change in body weight measure: Changes in body circumference measure: Body composition analysis measure: Abdominal visceral fat tissue thickness measure: Fasting blood glucose (FPG) measure: Blood lipid profile measure: Impact of Weight on Quality-of-Life Scale (IWQOL-Lite) measure: Well-Being Index (WHO-5) measure: Visual analog scale (VAS) of appetite measure: Hamilton Anxiety Scale (HAMA) measure: Adverse effects sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Shanghai Municipal Hospital of Traditional Chinese Medicine status: RECRUITING city: Shanghai state: Shanghai zip: 200071 country: China name: Shifen Xu, PhD role: CONTACT phone: +8613761931393 email: xu_teacher2006@126.com lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06316284 id: miRNA-CKD briefTitle: miRNA in Chronic Kidney Diseases overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-12-31 date: 2026-12-31 date: 2024-03-18 date: 2024-03-18 name: Josip Juraj Strossmayer University of Osijek class: OTHER name: University Hospital Center Osijek briefSummary: Oxidative stress and endoplasmic reticulum (ER) stress play a key role in tubular damage in both acute kidney injury and chronic kidney disease (CKD). Oxidative stress in the kidneys promotes renal vascular remodeling and increases preglomerular resistance. These are key elements in hypertension, acute and chronic kidney injury, as well as diabetic nephropathy. Chronic renal hypoxia is highlighted as the final common pathway to end-stage renal disease (ESRD). MicroRNA molecules (miRNA) also play an important role in these processes. MicroRNAs (miRNAs) are regulators of gene expression and play a role in the progression of renal ischemia-reperfusion injury. Although the pathophysiological contribution of microRNAs (miRNAs) to kidney damage has also been highlighted, the effect of miRNAs on kidney damage under conditions of oxidative and ER stress remains understudied. conditions: Chronic Kidney Diseases studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 90 type: ESTIMATED measure: Systemic microvascular function measure: Serum level of antixidant enzymesprotein concentration of SOD, CAT and glutathione-peroxidase measure: Detecton of miRNA of interest measure: Body fluid compartments sex: ALL minimumAge: 18 Years maximumAge: 69 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Medicine Osijek city: Osijek zip: 31000 country: Croatia lat: 45.55111 lon: 18.69389 hasResults: False
nctId: NCT06316271 id: PreHT 2024 briefTitle: Endothelial Function in Prehypertension overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2026-12-31 date: 2024-03-18 date: 2024-03-18 name: Josip Juraj Strossmayer University of Osijek class: OTHER name: University Hospital Center Osijek briefSummary: In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and macrocirculation, reduces re-endothelialization potential of human endothelial progenitor cells (EPCs) and increases the level of endothelial extracellular vesicles (EVs), which are accompanied by increased oxidative stress level. Furthermore, initial vascular and left ventricle (LV) remodeling contributes to changes in systemic hemodynamics and may be influenced by altered regulatory role of renin-angiotensin system (RAS) and autonomic nervous system (ANS) in PreHT but otherwise healthy individuals. To distinguish high normal blood pressure effect from those considered normal or high, study will be performed in three groups of individuals: prehypertensive (BP 130-139/85-89 mmHg), hypertensive (stage I, BP 140-150/90-100 mmHg), and controls (BP less than or equal to 129/85 mmHg). Altogether, the impairment of normal vascular relaxation mechanisms, endothelial activation as well as vascular and LV remodeling could play crucial role in increased cardiovascular risk and CVDs incidence in PreHT individuals. Moreover, the prognostic significance of assessing endotehlial dysfunction in hypertension (as well as in PreHT) is yet to be established. conditions: Hypertension,Essential studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 90 type: ESTIMATED measure: Systemic microvascular function measure: Systemic macrovascular function measure: Aortic stiffness measure: Left ventricle global longitudinal strain measure: Oxidative stress - 8-iso-prostaglandin F2α (8-iso-PGF2α) measure: Activity of renin-angiotensin system (RAS) measure: Endothelial progenitor cells (EPCs) measure: Endothelial extracellular vesicles (eEVs) measure: Systemic peripheral vascular resistance measure: Autonomic nervous system (ANS) activity measure: Matrix metalloproteinase 9 sex: ALL minimumAge: 18 Years maximumAge: 69 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Medicine Osijek city: Osijek zip: 31000 country: Croatia lat: 45.55111 lon: 18.69389 hasResults: False
nctId: NCT06316258 id: 333112 briefTitle: Evaluating a CFT Group for Adults With Acquired Brain Injury overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-30 date: 2025-05-30 date: 2024-03-18 date: 2024-03-18 name: King's College London class: OTHER briefSummary: Emotional difficulties such as anxiety and depression are common after experiencing a brain injury. The compassion focused therapy (or CFT) model proposes the importance of developing skills in being able to self-soothe and be self-compassionate to counteract feelings of distress. Several studies have shown that therapy groups using CFT techniques are helpful, but there has only been one previous study of a CFT group with people with acquired brain injury. This study aims to evaluate a new CFT group for people who have had a brain injury and are currently receiving inpatient neuro-rehabilitation. The group will have six weekly sessions with 4-6 people in each group. The group will be run at the inpatient neuro-rehabilitation unit. As this is a new group that has not been run before, it will be a small study to see whether the group is feasible and acceptable to attendees. The study will evaluate whether the group can be run as planned and how many people attend. The investigators will also interview people who attended the group to find out what they thought of the group.
This project is being completed as part of a Doctorate in Clinical Psychology at King's College London, and will be recruiting patients from an inpatient neurorehabilitation setting. conditions: Acquired Brain Injury Including Stroke studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 12 type: ESTIMATED name: Compassion focused therapy group measure: Demand - patients referred and screened for the group measure: Demand - patients recruited measure: Demand - attendance measure: Implementation - patients per group measure: Implementation - group sessions completed measure: Implementation - practice sessions completed measure: Practicality - delivery of intervention measure: Acceptability - end of session ratings scores measure: Acceptability - patient interview feedback measure: Change in emotional distress questionnaire score measure: Change in mental well-being questionnaire score measure: Change in self-compassion questionnaire score measure: Change in quality of life questionnaire score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06316245 id: 2024/178 briefTitle: Functional Capacity and Days Alive Out of Hospital at 30 Days overallStatus: RECRUITING date: 2024-03-19 date: 2024-10-19 date: 2024-12-19 date: 2024-03-18 date: 2024-03-20 name: Istanbul University class: OTHER briefSummary: This prospective observational study aims to compare days alive and out of hospital at 30 days (DAOH-30) in patients with poor or good functional capacity undergoing gastrointestinal surgeries. The investigators are testing the hypothesis that patients with good functional capacity will have longer days alive and out of hospital than those with poor. conditions: Gastrointestinal Surgery studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 470 type: ESTIMATED name: DASI questionnaire measure: Days alive and out of hospital at 30 days (DAOH-30) measure: Days alive and out of hospital at 90 days (DAOH-90) measure: Postoperative complications measure: The Postoperative Morbidity Survey (POMS) defined morbidity measure: Mortality measure: Intensive care unit (ICU) stay measure: Length of hospital stay after index surgery measure: Rehospitalization sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istanbul University Istanbul Medical Faculty, Department of Anesthesiology and Reanimation status: RECRUITING city: Istanbul state: Fatih zip: 34093 country: Turkey name: Muserref B Dincer role: CONTACT phone: +905321624712 email: mberildincer@gmail.com name: Ahmet K Koltka role: CONTACT email: koltkak@yahoo.com name: Muserref B Dincer role: PRINCIPAL_INVESTIGATOR lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06316232 id: DBS-FOG 2023 briefTitle: DBS and Levodopa for Treating Freezing of Gait in Parkinson's Disease overallStatus: RECRUITING date: 2023-10-10 date: 2026-12-31 date: 2026-12-31 date: 2024-03-18 date: 2024-03-18 name: IRCCS Istituto delle Scienze Neurologiche di Bologna class: OTHER name: Azienda Ospedaliera Città della Salute e della Scienza di Torino briefSummary: Freezing of gait (FoG) is a complex symptom of Parkinson's disease (PD) that cause falls and disability in PD patients, heavily affect patients' autonomy and quality of life. Gait disturbances and FoG are difficult to manage as they usually do not complete respond to both dopaminergic treatment and subthalamic nucleus deep brain stimulation (STN-DBS). One therapeutic strategy suggested in literature for improving gait disturbances is to increase the dose of dopaminergic drugs according to the hypothesis of pseudo-ON-freezing. The pseudo-ON-FoG in patients treated with STN-DBS can easily occur as the result of a suboptimal stimulation or the consequence of a post-operative reduction of the dopaminergic therapy. Therefore, it is reasonable hypothesize both the increase of stimulation and levodopa as good therapeutic strategies to improve pseudo-ON-FoG. At present there are no evidence for suppose that one option is better than the other, even though two recent studies on gait analysis reported a positive additive effect of levodopa therapy on gait parameters in patients treated with STN-DBS.
In this study, the investigators aim to objectively evaluating the improvement of FoG in PD patients treated with STN-DBS at different treatment conditions consisting of increased intensity of stimulation or higher dosage of levodopa. conditions: Freezing of Gait conditions: Parkinson Disease studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: In addition to baseline gait assessment performed in a morning session on MED ON/STIM ON condition (after usual levodopa morning dose and usual parameters of stimulation), patients are evaluated in two following morning sessions under different treatment conditions:
2. MED ON plus: evaluation after the administration of a 2x levodopa morning dose with usual parameters of stimulation. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The count and duration of FoG episodes during the standardize walking protocol is measured on video-assessment by two blind raters. whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: STIM ON plus name: MED ON plus measure: Time spent with FOG during protocol measure: Gait performance measure: MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III measure: Patient global impression of change (PGI-C) measure: Trail Making test A and B measure: Phonemic/Semantic alternate Fluency test sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Istituto delle Scienze Neurologiche di Bologna status: RECRUITING city: Bologna zip: 40139 country: Italy name: Ilaria Cani role: CONTACT phone: 0039 051 4966959 email: ilaria.cani@studio.unibo.it name: Giulia Giannini role: CONTACT phone: 0039 051 4966959 email: giulia.giannini15@unibo.it name: Giovanna Calandra Buonaura, MD, PhD role: SUB_INVESTIGATOR name: Ilaria Cani, MD role: SUB_INVESTIGATOR name: Carlo Alberto Artusi, MD, PhD role: SUB_INVESTIGATOR name: Giulia Giannini, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 44.49381 lon: 11.33875 hasResults: False