hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06301009 id: AI-CAC-PVS briefTitle: The AI-CAC Model for Subclinical Atherosclerosis Detection on Chest X-ray acronym: AI-CAC-PVS overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-10-01 date: 2025-10-01 date: 2024-03-08 date: 2024-03-08 name: Azienda Ospedaliera Città della Salute e della Scienza di Torino class: OTHER name: Compagnia di San Paolo briefSummary: The AI-CAC model is an artificial intelligence system capable of assessing the presence of subclinical atherosclerosis on a simple chest radiograph. The present study will provide prospective validation of its diagnostic performance in a primary prevention population with a clinical indication for coronary artery calcium (CAC) testing. conditions: Cardiovascular Diseases conditions: Atherosclerosis conditions: Coronary Artery Calcification studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 500 type: ESTIMATED name: AI-CAC score measure: Diagnostic accuracy of the AI-CAC score to identify the presence of subclinical atherosclerosis on chest x-ray measure: Percentage of individuals with a therapeutic management change by the attending physician based on the CAC score, with concordant AI-CAC. measure: Comparison of ASCVD events occurring in patients without (AI-CAC=0) vs. with subclinical atherosclerosis (AI-CAC >0) based on the AI-CAC score, as assessed by Kaplan Meier estimates of ASCVD events occurring until study completion. sex: ALL minimumAge: 40 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06300996 id: STUDY23110042 briefTitle: Spinal Cord Stimulation for the Treatment of Motor Deficits in People With Spinal Muscular Atrophy - Upper Limb overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-05 date: 2029-05 date: 2024-03-08 date: 2024-04-03 name: Marco Capogrosso class: OTHER name: Roche-Genentech briefSummary: Spinal cord stimulation (SCS) has shown remarkable efficacy in restoring motor function in people with spinal cord injury by recruiting afferent input to enhance the responsiveness of spared neural circuits to residual cortical inputs. This pilot will test if SCS can show evidence to improve motor deficits in people with Type 2, 3, or 4 spinal muscular atrophy (SMA). The investigators will enroll up to six subjects with Type 2, 3, or 4 SMA aged 16 or older that show quantifiable motor deficits of the upper body. The investigators will then implant the subjects with percutaneous, linear spinal leads near the cervical spinal cord for a period of up to 29 days. Although these leads are not optimized for motor function but rather for their clinically approved indication of treating pain, the investigators believe they provide a safe technology enabling our team to perform scientific measurement necessary to evaluate potential for effects of SCS in motor paralysis with SMA. After the end of the study, the leads will be explanted. conditions: Spinal Muscular Atrophy conditions: Spinal Muscular Atrophy Type 3 conditions: Spinal Muscular Atrophy Type II conditions: Spinal Muscular Atrophy 4 conditions: SMA studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single-arm, open-label study performed to quantify variables that are predictive of the efficacy of spinal cord stimulation to improve motor control. primaryPurpose: BASIC_SCIENCE masking: NONE count: 20 type: ESTIMATED name: Spinal Cord Stimulator (Octopolar Medtronic Vectris Leads) measure: Muscle Weakness Torque measure: Number and Severity of Adverse Events measure: Muscle Weakness Muscle Activation measure: Motor Function ROM measure: Motor Function RULM measure: Motor Function Fatigue measure: Discomfort/Pain measure: Sensorimotor Network Structure Density measure: Impression measure: Sensorimotor Network Structure Integrity measure: Sensorimotor Network Function measure: Cortico-spinal Tract Integrity measure: Spinal Circuit Excitability measure: Motoneuron Firing Rates measure: Motor Firing Number sex: ALL minimumAge: 16 Years maximumAge: 65 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: University of Pittsburgh city: Pittsburgh state: Pennsylvania zip: 15213 country: United States name: Sydney Bader, MS role: CONTACT email: syb17@pitt.edu name: Cierra Clark, MS role: CONTACT email: cic27@pitt.edu lat: 40.44062 lon: -79.99589 hasResults: False
nctId: NCT06300983 id: PR(AG)398/2022 briefTitle: Effectiveness of a Psychoeducational Intervention on Myositis Patients' Quality of Life and Well-Being acronym: HRQoL overallStatus: COMPLETED date: 2022-09-15 date: 2022-10-31 date: 2022-10-31 date: 2024-03-08 date: 2024-03-08 name: Hospital Universitari Vall d'Hebron Research Institute class: OTHER briefSummary: Purpose. Myositis is a rare disease associated with impaired health-related quality of life. A study evaluating the effectiveness of an intervention to improve the quality of life and well-being of myositis patients is presented.
Materials and Methods. All myositis patients in a health district are contacted. Eligible patients are randomly assigned to the experimental or control group. A psychoeducational intervention of 5 100-min sessions focusing on the disease as related to daily life is conducted only in experimental patients. Several reliable tools to measure quality of life and well-being are administered twice, before and after the intervention, to both groups. conditions: Quality of Life conditions: Myositis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 34 type: ACTUAL name: Psychoeducative name: Placebo measure: Health related quality of life sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Universitari Vall d'Hebron. Universitat Autonoma de Barcelona city: Barcelona zip: 08035 country: Spain lat: 41.38879 lon: 2.15899 hasResults: False
nctId: NCT06300970 id: 0900f3eb81e634a9 briefTitle: Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Treatment of Plasmodium Falciparum Malaria in Liberia overallStatus: COMPLETED date: 2022-08-09 date: 2023-08-16 date: 2023-08-16 date: 2024-03-08 date: 2024-03-08 name: Centers for Disease Control and Prevention class: FED name: Ministry of Health, Liberia briefSummary: To assess the efficacy of both first-line antimalarial medications used for the treatment of uncomplicated Plasmodium falciparum malaria infections in two geographic regions in Liberia. conditions: Plasmodium Falciparum conditions: Malaria conditions: Uncomplicated Malaria studyType: INTERVENTIONAL phases: PHASE4 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 352 type: ACTUAL name: Amodiaquine-artesunate (ASAQ) name: Artemether+Lumefantrine (AL) measure: Number of Participants with Early Treatment Failure (ETF) measure: Number of Participants with Late Treatment Failure (LTF) measure: Number of Participants with Adequate Clinical and Parasitological Response (APCR) measure: Number of Patients with Adverse Events measure: Number of samples with confirmed Histidine-rich protein 2/3 (HRP2/3) gene deletions measure: Number of samples with molecular markers of anti-malarial resistance sex: ALL minimumAge: 6 Months maximumAge: 59 Months stdAges: CHILD facility: Sinje Health Center, Garwula District, Sinje, Grand Cape Mount County city: Sinje state: Grand Cape Mount County country: Liberia facility: Saclepea-Mahn Comprehensive Health Center Saclepea-Mahn District, Nimba County city: Saclepea state: Nimba County country: Liberia lat: 6.9625 lon: -8.84056 hasResults: False
In Phase two, investigators will recruit 300 participants to take part in the RCT, 200 in the HW group and 100 in the WL group. After consenting to participate and completing the first online survey, participants will be randomized to either an intervention condition (N =200) or wait-list control condition (N =100) using a 2:1 allocation. The intervention group will gain access to Help Wanted for 1 month after which the participants will complete a post-intervention survey and then a three-month follow up survey. Participants in the control group will receive alternative resources for one month, then complete a one-month post-waitlist survey before being granted access to Help Wanted for a one-month period. The control group participants will then complete a one-month post-intervention survey and three-month follow-up survey. primaryPurpose: PREVENTION masking: NONE count: 310 type: ESTIMATED name: Help Wanted Prevention Intervention name: Waitlist Control measure: Sexual Behavior Involving Minors Scale (SBIMS). measure: Sexual Child Molestation Risk Assessment (SChiMRA) score measure: Depression, Anxiety and Stress Scale-21 (DASS-21) measure: Suicidal Ideation Attributes Scale (SIDAS) measure: General Self-Efficacy Scale - Short Form (GSE-6). measure: Revised University of California, Los Angeles (UCLA) Loneliness Scale measure: Self-Efficacy Scale Related to Minors (SESM) measure: Hypersexual Behavior Inventory-19 score measure: Sexual Attraction to Children measure: Cognitions of internet sexual offending score measure: Cognitions that condone and support sexual offending against children scale - short form measure: Emotional Congruence with Children score measure: Brief Aggression Questionnaire score measure: Short Self-Regulation Questionnaire score measure: Alcohol Use Disorders Identification Test (AUDIT) score measure: Recent Alcohol & Cannabis Use score measure: Demographic characteristics as assessed by survey developed by study team measure: Number of Sexual Health Services Used measure: Sexual Offence Self-Report Risk Scale (SOSRS): measure: Minor Attraction Outness Scale measure: Revised Adverse Childhood Experiences Scale measure: Balanced Inventory of Desirable Responding - Impression Management Subscale (BIDR-Version 6-Form 40 - IMS). measure: Impact of Research Participation as assessed by survey sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Johns Hopkins Bloomberg School of Public Health status: RECRUITING city: Baltimore state: Maryland zip: 21231 country: United States name: Elizabeth J Letourneau, PhD role: CONTACT phone: 843-343-6865 email: elizabethletourneau@jhu.edu name: Amanda E Ruzicka, MA role: CONTACT phone: 7172699886 email: aruzicka@jhu.edu lat: 39.29038 lon: -76.61219 hasResults: False
nctId: NCT06300944 id: Ran Gao-2023-12 briefTitle: The Effect of Esketamine on Postoperative Pain Relief in Patients Undergoing Laparoscopic Surgery overallStatus: RECRUITING date: 2023-12-01 date: 2024-10-01 date: 2024-10-01 date: 2024-03-08 date: 2024-03-08 name: General Hospital of Ningxia Medical University class: OTHER briefSummary: The purpose of this study is to investigate whether continuous intraoperative infusion of esketamine combined with the addition of esketamine to postoperative PCIA can improve postoperative pain and sleep quality in patients undergoing laparoscopic uterine surgery under general anesthesia. conditions: Postoperative Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: parallel assignment primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 108 type: ESTIMATED name: saline name: Esketamine measure: Moderate to severe pain measure: Incidence of adverse reactions including nausea, vomiting and dizziness measure: Sleep quality measure: Remifentanil dosage measure: Additional post-operative analgesics measure: Postoperative exhaust time of patients sex: FEMALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: General Hospital of Ningxia Medical University status: RECRUITING city: Yinchuan state: Ningxia country: China name: Ma Hanxiang role: CONTACT phone: 86-13519591508 email: mahanxiang@hotmail.com lat: 38.46806 lon: 106.27306 hasResults: False
nctId: NCT06300931 id: KAPSDFE0948 briefTitle: KAP for Use of SDF Among Dental Interns Before vs After Educational Intervention overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-09 date: 2024-10 date: 2024-03-08 date: 2024-03-08 name: Cairo University class: OTHER briefSummary: This study is a KAP questionnaire to assess Egyptian intern dentists' knowledge, attitudes and practices regarding use of SDF before and after an educational intervention. conditions: SDF studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: OTHER count: 449 type: ESTIMATED name: educational lecture measure: Assessment of knowledge levels and attitude regarding SDF use before educational intervention measure: Assessment of knowledge levels and attitude regarding SDF use after educational intervention Correlation between demographic data and use of SDF. sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06300918 id: 2024-KY76 briefTitle: A Clinical Trial to Evaluate the Time Point of Anti-VEGF Pretreatment of PDR Based on Intraoperative FFA overallStatus: RECRUITING date: 2024-03-08 date: 2025-08-01 date: 2025-08-01 date: 2024-03-08 date: 2024-03-19 name: Jie Li class: OTHER briefSummary: The goal of this prospective randomized controlled study is to compare the therapeutic effect of injecting anti-VEGF drugs before surgery for patients with proliferative diabetic retinopathy at different time points. At present, studies have confirmed that anti-VEGF drugs are effective in inhibiting fundus neovascularization in proliferative diabetic retinopathy. The main question it aims to answer is which time point is better to injecting anti-VEGF drugs before surgery for patients with proliferative diabetic retinopathy.
Participants will be randomly divided into three groups. And time points of injecting anti-VEGF drugs before surgery for each group will be 3 days, 7 days, 14 days. And we have a new technology that can have fluorescein fundus angiography during operation, so it can reflect the condition of fundus neovascularization immediately and precisely. In that case, we can compare the Inhibitory effect of anti-VEGF drugs on fundus neovascularization at different time points. conditions: The Condition of Fundus Neovascularization studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: Time measure: The number of fundus neovascularization seen in FFA. measure: The area of fundus neovascularization seen in FFA (using PD size as measurement). measure: The intensity of neovascularization fluorescein leakage sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sichuan Academy of Medical Science Sichuan Provincial Hosptial status: RECRUITING city: Chendu state: Sichuan zip: 610014 country: China name: Jie Li, doctor role: CONTACT phone: +86 13908094675 email: lijieyk@med.uestc.edu.cn hasResults: False
nctId: NCT06300905 id: CRO-2023-05-OMO-SNA-YPZ briefTitle: Clinical Study on Malodor overallStatus: COMPLETED date: 2023-06-01 date: 2023-07-02 date: 2023-07-02 date: 2024-03-08 date: 2024-03-08 name: Colgate Palmolive class: INDUSTRY briefSummary: This 3-week clinical study was designed to investigate the clinical efficacy on oral malodor of a 0.454% stannous fluoride toothpaste with nitrate and pyrophosphate (referred to as SNAP) compared to Colgate Cavity Protection Toothpaste containing 0.76% sodium monofluorophosphate 12 hours post-brushing after 3 weeks of product use. conditions: Oral Malodor studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 100 type: ACTUAL name: test product name: Control product measure: Organoleptic Oral Malodor Evaluations sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: West China Dental Institute of Chengdu city: Chengdu state: Sichuan zip: 610041 country: China lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06300892 id: SURG-2023-31841 briefTitle: Surgical Site Infections and the Microbiome: Understanding the Pathogenesis of Surgical Site Infections overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-12-01 date: 2025-12-01 date: 2024-03-08 date: 2024-03-08 name: University of Minnesota class: OTHER briefSummary: This is a prospective, observational study of patients undergoing open GI surgery. At the time of operation, samples will be collected from the incision site and GI tract. The study will follow patients up to 30 days postoperatively, monitoring for signs of SSI. Samples will be taken from all patients who develop SSI. Sequencing will be performed on a subset of samples based on our specific aims.
* Aim 2: identify the strain of bacteria isolated from SSIs using shotgun metagenomic sequencing and determine whether the specific strain was present in the skin and gut at the time of operation. conditions: Open GI Surgery studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 300 type: ESTIMATED name: No intervention measure: alpha diversity composition measure: microbial community composition measure: pathogenic strain of bacteria sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06300879 id: 2023-1058 briefTitle: A Prospective Study on Esophagogastrostomy by an Innovative Surgical Technique overallStatus: RECRUITING date: 2024-01-01 date: 2025-12-31 date: 2026-06-30 date: 2024-03-08 date: 2024-03-08 name: Huashan Hospital class: OTHER briefSummary: This is a single-center, open-label, Phase Ib/II study aiming to assess the perioperative safety and postoperative outcomes of a novel surgical technique in treating primary adenocarcinoma located in the upper 1/3 of the stomach or gastroesophageal junction (Siewert II or III).
The study will enroll 30 patients who will undergo totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique. Clinical data will be collected to evaluate perioperative safety. Patients will be followed for at least 3 months, during which endoscopy will be performed to analyze occurrences and reasons for anastomotic-related complications. Additionally, the quality of life after surgery will be evaluated by QLQ-C30 and QLQ-STO22. conditions: Gastric Cancer conditions: Adenocarcinoma of Esophagogastric Junction studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Patients included in this group will receive totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique，which is an innovative surgery that investigators first began to apply in patients with proximal gastric cancer. primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Performing totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique measure: Assess intraoperative Perioperative Safety by Duration of surgery. measure: Assess intraoperative Perioperative Safety by Duration of anastomosis. measure: Assess intraoperative Perioperative Safety by blood loss . measure: Postoperative recovery course measure: Postoperative TNM staging by Pathological findings . measure: The incidence of postoperative reflux esophagitis measure: The incidence of postoperative anastomotic stenosis measure: Quality of Life at 3 Months Postoperatively will be assessed by EORTC QLQ-C30 measure: Quality of Life at 3 Months Postoperatively will be assessed by EORTC QLQ-STO22 scale sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Huashan Hospital, Fudan University status: RECRUITING city: Shanghai state: Shanghai zip: 200040 country: China name: Hankun Hao, doctor role: CONTACT phone: +86 18121186328 email: haohankun@163.com lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06300866 id: CRO-2020-04-PGN-LLU-YPZ briefTitle: Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste overallStatus: COMPLETED date: 2020-08-18 date: 2021-03-08 date: 2021-03-08 date: 2024-03-08 date: 2024-03-08 name: Colgate Palmolive class: INDUSTRY briefSummary: The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the stannous fluoride containing toothpaste (SNAP) compared to Colgate Cavity Protection Toothpaste after 3 and 6 months of product use. conditions: Gingivitis conditions: Plaque, Dental studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 80 type: ACTUAL name: Test name: Control measure: Whole-Mouth Gingivitis Measurement measure: Whole-Mouth Dental Plaque Measurement sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Loma Linda University School of Dentistry city: Loma Linda state: California zip: 92350 country: United States lat: 34.04835 lon: -117.26115 hasResults: False
nctId: NCT06300853 id: 2023-07 briefTitle: Understanding Adaptive Immune Response After COVID-19 Vaccination Boosters to Improve Vaccination Strategies in Vulnerable Groups. acronym: COVaxFragile overallStatus: RECRUITING date: 2023-11-14 date: 2025-11 date: 2025-11 date: 2024-03-08 date: 2024-03-08 name: IRCCS Sacro Cuore Don Calabria di Negrar class: OTHER briefSummary: This is an experimental study without drug and device, non-profit, single-center.