hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06298513 id: 09C338 briefTitle: Autonomic and Metabolic Response to Cardiac Rehabilitation After Acute MI acronym: RIABILITOMICA overallStatus: RECRUITING date: 2023-05-02 date: 2025-04 date: 2025-12 date: 2024-03-07 date: 2024-03-07 name: Istituto Auxologico Italiano class: OTHER briefSummary: Ischemic heart disease remains the leading cause of death in the western world. The beneficial effects of cardiac rehabilitation on the evolution of ischemic heart disease are known, but the effects of rehabilitation on the metabolic processes of the patients are so far poorly understood. Metabolomics is the qualitative/quantitative analysis of the body's metabolic responses to pathophysiological stimuli or genetic alterations. Metabolic changes caused by physical activity have been demonstrated in obese and diabetic patients and in athletes. Aim of the study is to evaluate whether cardiac rehabilitation after a first myocardial infarction induces changes in the metabolic state of patients, and whether these changes may be related with changes in the usual risk factors (i.e. glyco-lipidic profile, natriuretic peptides, homocysteine). conditions: Acute Myocardial Infarction: Rehabilitation Phase studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 25 type: ESTIMATED name: Cardiac rehabilitation measure: Changes in purine after rehabilitation measure: Changes in histidine after rehabilitation measure: Changes in galactose after rehabilitation sex: MALE minimumAge: 25 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istituto Auxologico Italiano status: RECRUITING city: Milan zip: 20149 country: Italy name: Lia Crotti, MD PhD role: CONTACT phone: 39 0261911 phoneExt: 2903 email: lia.crotti@unimib.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06298500 id: AAG-O-H-2115 briefTitle: Clinical Performance of HISTOACRYL® LAPFIX - CANNULA for Laparoscopic Inguinal Hernia Repair acronym: HISTOLAP overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-06 date: 2024-09 date: 2024-03-07 date: 2024-03-08 name: Aesculap AG class: INDUSTRY name: B.Braun Surgical SA briefSummary: The goal of this retrospective study is to identify the incidence of hernia recurrence following the application of Histoacryl® Lapfix - Cannula for laparoscopic mesh fixation in patients undergoing hernia repair surgery. All adult patients who underwent laparoscopic inguinal hernia repair with Histoacryl® Lapfix - Cannula in the period June 2018 - March 2021 at Hospital San Juan de Dios will be analysed. The investigator team will access electronical medical records for the cohort of patients identified. conditions: Inguinal Hernia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 448 type: ESTIMATED name: hernia repair surgery measure: Hernia recurrence rate measure: Delayed tissue adhesive polymerization measure: Intraoperative bleeding requiring therapeutic measures measure: Organ injury measure: Hernia recurrence measure: Mesh migration measure: Adhesions measure: Erosion measure: Meshoma formation measure: Tack hernias measure: Surgical Site Infection (superficial, deep, intraabdominal) measure: Hematoma measure: Seroma measure: Hemorrhage measure: Orchitis measure: Other Adverse Event measure: Reintervention measure: Mesh repositioning or removal measure: Acute or chronic pain sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital San Juan de Dios city: Santa Cruz De Tenerife state: Tenerife zip: 38001 country: Spain name: José Miguel Del Pino Monzón, Dr. role: CONTACT lat: 28.46824 lon: -16.25462 hasResults: False
nctId: NCT06298487 id: CHRD 1023 briefTitle: Evaluation of the Impact of Therapeutic Education Workshops for COPD Patients in the North-West Val d'Oise Area acronym: MPSAT-ETP overallStatus: RECRUITING date: 2024-03-11 date: 2024-09 date: 2024-09 date: 2024-03-07 date: 2024-04-04 name: Hôpital NOVO class: OTHER briefSummary: The aim of this study is to assess the impact of the Patient Therapeutic Education (PTE) workshops offered by the Maison de Prévention de la Santé et d'Accompagnement Thérapeutique (MPSAT) on the follow-up and feelings of the COPD patients who take part. These workshops are organised outside the hospital environment and supervised by hospital and town professionals in the NOVO zone. conditions: COPD studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 100 type: ESTIMATED name: Patient questionnaires measure: Evaluation of the overall impact of the PTE workshops offered by the MPSAT on patients' knowledge, skills, attitudes and behaviours with regard to COPD management and care measure: Measure of the impact of PTE workshops on quality of life (comparison of PTE group versus Control group) measure: Comparison of anxiety/depression levels in patients in the PTE group versus Control group measure: Comparison of levels of motivation towards physical activity during free time in the PTE group versus Control group measure: Comparison of the number of hospital admissions for COPD exacerbations in patients in the PTE group versus Control group measure: Comparison of the perception/feelings of patients in the PTE group versus Control group, concerning PTE workshops organised in a city/hospital setting sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pneumology, respiratory rehabilitation and follow-up and rehabilitation care department - Hôpital NOVO status: RECRUITING city: Pontoise zip: 95300 country: France name: Dr Bruno PHILIPPE role: CONTACT phone: +33 1 30 75 47 75 email: bruno.philippe@ght-novo.fr name: Mme Anne-Charlotte TAUVERON role: CONTACT phone: +33 6 75 08 36 60 email: anne-charlotte.tauveron@valdoise.fr lat: 49.05 lon: 2.1 hasResults: False
nctId: NCT06298474 id: 2R44AG071105-03 type: NIH link: https://reporter.nih.gov/quickSearch/2R44AG071105-03 briefTitle: The BRAIN App (Phase 2 SBIR) overallStatus: NOT_YET_RECRUITING date: 2025-02-15 date: 2025-11-15 date: 2025-11-30 date: 2024-03-07 date: 2024-03-26 name: Hopeful Aging class: INDUSTRY briefSummary: There are currently 6.7 million Americans living with dementia and, without significant breakthroughs, this figure will double to 12.7 million by 2050. There are about 46,000 long-term care (LTC) facilities in the U.S. More than half of LTC residents have some form of dementia (Alzheimer's Association, 2018). Responsive behaviors and dysfunction of the dementia care triad-i.e., the PLWD, professional Care Partner (CP), and Family Member (FM)-are inexorably linked. The emergence of responsive behaviors can lead to disruption of the triad's function. Thus, it is imperative to maintain positive relationships and a high quality of life (QoL) within the triad to reduce BPSD. Cognitive Stimulation Therapy (CST) has demonstrated improvements in QoL and relationships for PLWD. CST is a psychosocial intervention that promotes communication and engagement in PLWD via a structured program of meaningful and enjoyable theme. While clinical trials have shown improvement in cognition and QoL, the potential large-scale impact of CST has been hampered by low adherence, with less than 40% completing trials. One likely reason for the low adherence to CST is the reliance on generic and non-digital tools (e.g., paper-based agendas, tools, DVDs, and board games) in facilitating the intervention. That is, even though CST aims to be personalized, the specific interventions used in the field tend to be generic and not tailored to each PLWD's specific interests. The use of digital technology to implement CST would offer considerable advantages to expand and personalize the range of stimulation content and provide a means for monitoring responses, optimizing protocols, and promoting adherence.
nctId: NCT06298461 id: BowelPrep briefTitle: Bowel Preparation for Colonoscopy Among Individuals With Crohn's and Ulcerative Colitis Disease. overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-03 date: 2025-06 date: 2024-03-07 date: 2024-03-07 name: University of Manitoba class: OTHER name: Canadian IBD Research Consortium (CIRC) briefSummary: The purpose of this study is to compare how effective and how tolerable two different bowel preparation laxatives are for colonoscopy. The aim is to compare oral sulfate solution (OSS) to another laxative called 2L polyethylene glycol (PEG) solution to see which is more effective and more tolerable by individuals with IBD (Crohn's disease or Ulcerative colitis). conditions: Crohn Disease conditions: Ulcerative Colitis studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 418 type: ESTIMATED name: KleanLyte name: Bi-PegLyte measure: Quality of bowel cleanliness measure: Quality of bowel cleanliness measure: Volume of laxative intake measure: Endoscopic Outcomes measure: Endoscopic Outcomes measure: Endoscopic Outcomes measure: Endoscopic Outcomes measure: Patient experience data measure: Crohn's disease or ulcerative colitis flares after colonoscopy measure: Endoscopic Outcomes sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06298448 id: NL83176.042.23 briefTitle: eGPA and Local Inflammation Within the Ear, Nose and Throat Area overallStatus: RECRUITING date: 2024-02-14 date: 2027-12 date: 2028-12 date: 2024-03-07 date: 2024-03-07 name: University Medical Center Groningen class: OTHER name: GlaxoSmithKline briefSummary: Rationale: Eosinophilic Granulomatosis with Polyangiitis (eGPA), eosinophilic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) are airway diseases where eosinophils and interleukine-5 are involved in the pathogenesis. eGPA differs from the other diseases with respect to involvement of other organs. The investigators hypothesize that nasal microbiome dysbiosis with a central augmenting role for S. Aureus plays an important role in disease expression. The investigators expect that anti-interleukin-5 treatment with mepolizumab restores the changes of the nasal microbiome and immune responses to a healthy control phenotype. To study this, the nasal microbiome, the local and systemic immune response and the effect of mepolizumab treatment will be assessed. conditions: EGPA - Eosinophilic Granulomatosis With Polyangiitis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 150 type: ESTIMATED name: laboratory experiments before and after mepolizumab treatment measure: The effect mepolizumab treatment has on the nasal microbiome profiles measure: Exploratory evaluation of between group differences measure: Mepolizumab effect on outcome 2 measure: s there a correlation between the disease activity, the quality of life and the microbiome and immune parameters? sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UMC Groningen status: RECRUITING city: Groningen zip: 9700RB country: Netherlands name: Abraham Rutgers, MD-PhD role: CONTACT phone: +31503616161 email: a.rutgers@umcg.nl lat: 53.21917 lon: 6.56667 hasResults: False
nctId: NCT06298435 id: 17536 briefTitle: Optimising Ventilatory Strategies by Using Positive Respiratory Integer Measurements acronym: OPTIMVSPRIME overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-04-01 date: 2025-04-01 date: 2024-03-07 date: 2024-03-07 name: University Medical Center Groningen class: OTHER briefSummary: • Background Intermittent Positive Pressure Ventilation is used during general anesthesia but can lead to serious complications. Respiratory parameter settings can be adjusted to minimize the detrimental effects of this unphysiological artificial respiration. Determining optimal ventilator settings is a multifactorial problem with many possible realisations. Knowledge of the relationship of patient outcomes with mathematically identifiable integer sets of ventilator setting parameters may help to understand which effects ventilator settings have on patient outcomes. An exploratory database study can provide a basis for further, prospective, interventional studies to find the optimal combination of ventilator settings.
* Expected results Using mathematically identifiable integer ventilatory parameter sets improves respiratory and/or hemodynamic patient outcomes. conditions: Hypoxemia conditions: Hypercapnia conditions: Ventilator Associated Pneumonia conditions: Complication of Anesthesia conditions: Postoperative Complications studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 20000 type: ESTIMATED name: Intermittent Positive pressure ventilation measure: SpO2/FiO2 ratio measure: SpO2 measure: etCO2 measure: Blood Pressure measure: Heart Rate measure: Positive end Expiratory Pressure measure: Plateau Pressure measure: Respiration rate sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UMCG city: Groningen zip: 9700RB country: Netherlands name: Rob Spanjersberg role: CONTACT phone: +31503616161 email: r.spanjersberg@umcg.nl lat: 53.21917 lon: 6.56667 hasResults: False
nctId: NCT06298422 id: 806433 briefTitle: Oxygen Saturations Across Tones of Skin acronym: O2SATS overallStatus: RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-06-30 date: 2024-03-07 date: 2024-03-07 name: University of California, San Diego class: OTHER briefSummary: Pulse oximetry, or SpO2, is a vital sign used across healthcare systems to gauge how much oxygen blood is carrying as a percentage of the maximum it could carry. Recent research has suggested that current SpO2 monitors may inaccurately report high SpO2 in patients with darker skin tones when the actual oxygenation is at unsafe, low levels. Additionally, this new research suggests as the SpO2 levels decrease, the risk of occult hypoxia rises. The investigators hypothesize melanin interferes with the pulse oximetry accuracy. Investigators will use spectrophotometry to measure melanin indices and other variables to test this hypothesis. conditions: Generalised Melanin Pigmentation conditions: Pulse Oximetry studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED measure: Difference observed between SpO2 and SaO2. measure: Melanin Index sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UCSD Health status: RECRUITING city: San Diego state: California zip: 92103 country: United States name: Pamela DeYoung role: CONTACT phone: 858-232-0343 email: pdeyoung@health.ucsd.edu lat: 32.71533 lon: -117.15726 hasResults: False
nctId: NCT06298409 id: EB04 briefTitle: Evaluating the Effect Of Rifaximin on the Gut Microbiota and Metabolome in SIBO Using CapScan® overallStatus: RECRUITING date: 2024-02-15 date: 2024-09-15 date: 2024-12-15 date: 2024-03-07 date: 2024-03-07 name: Envivo Bio Inc class: INDUSTRY briefSummary: We will sample intestinal microbiota using a microbiome sampling capsule in patients with Small Intestinal Bacterial Overgrowth (SIBO) conditions: Small Intestinal Bacterial Overgrowth studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 34 type: ESTIMATED name: CapScan collection capsule measure: Sampling of gut microbiota measure: Sampling of gut metabolome measure: Effect of rifaximin on gut microbiota measure: Effect of rifaximin on gut metabolome sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Silicon Valley Gastroenterology status: RECRUITING city: Mountain View state: California zip: 94040 country: United States name: Jennifer Taufui role: CONTACT email: svgistaff@gmail.com lat: 37.38605 lon: -122.08385 hasResults: False
nctId: NCT06298396 id: CLTD5853 briefTitle: Investigating Stimulation Parameter and Electrode Mode Changes on Speech Perception in Experienced Adult Cochlear Implant Recipients acronym: DUAL overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-03-07 date: 2024-03-07 name: Cochlear class: INDUSTRY name: Avania briefSummary: This study aims to investigate the effect of stimulation parameters and different electrode modes on speech perception in adult cochlear implant recipients. conditions: Hearing Loss, Sensorineural studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE maskingDescription: There is no masking in this study as all participants receive all MAPs (single group study model). The term "single-blinded" in the official title refers to the fact that participants are blinded to the order in which they receive the MAPs. count: 20 type: ESTIMATED name: Program using default MAP name: Program using low-power 1 (LP1) MAP name: Program using low-power 2 (LP2) MAP name: Program using low-power 3 (LP3) MAP measure: Paired difference in percentage CNC words correct between default and LP1 MAPs in quiet setting measure: Paired difference in dB SRT (AuSTIN) between default and LP1 MAPs in noise measure: Paired difference in percentage CNC words correct between LP1 MAP and LP2 MAP in quiet setting measure: Paired difference in dB SRT (AuSTIN) between LP1 and LP2 MAPs in noise measure: Paired difference in percentage CNC words correct between LP1 and LP3 MAPs in quiet setting sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cochlear Macquarie city: Macquarie Park state: New South Wales zip: 2109 country: Australia name: Esti Nel role: CONTACT phone: +61448495008 email: Enel@cochlear.com lat: -33.7751 lon: 151.11272 hasResults: False
nctId: NCT06298383 id: ERU1 briefTitle: The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-07-15 date: 2024-09-15 date: 2024-03-07 date: 2024-03-07 name: Cairo University class: OTHER name: Egyptian Russian University briefSummary: Pain is a very important factor in Endodontic treatment, Both intra- and Post-operatively. In case of symptomatic Irreversible pulpitis, a build up of inflammatory mediators makes it very difficult for the operator to reach the desired level of anesthesia in order to deliver a pain free treatment as well as to eliminate or at least reduce post-operative pain incidence and severity. therefore, a number of pre- medications was suggested with variable success rates. Therefore this trial aims at the use of a new category of anti-inflammatory medications which would be less harmful than the standard NSAIDs or steroids. conditions: Symptomatic Irreversible Pulpitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: Trypsin, Bromelain and Rutoside name: Diclofenac Potassium name: Prednisolone Oral Tablet name: Placebo measure: Success of Anesthesia measure: Post-operative pain sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06298370 id: PENG study briefTitle: The Efficacy of Combined Intrathecal Morphine and PENG Block on Postoperative Pain in Hip Arthroplasty acronym: PENG overallStatus: RECRUITING date: 2024-03-18 date: 2024-06-08 date: 2024-07-08 date: 2024-03-07 date: 2024-03-07 name: Bezmialem Vakif University class: OTHER briefSummary: This study aims to compare the postoperative 48-hour period in terms of morphine consumption, postoperative pain, and quality of recovery scores by combining the Pericapsular Nerve Group (PENG) block with low-dose intrathecal morphine in hip arthroplasty, as opposed to PENG alone and intrathecal morphine alone. conditions: Postoperative Pain Management studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: prospective, double-blind, randomized clinical trial primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 3 type: ESTIMATED name: Pericapsular nerve group block plus intrathecal bupivacaine name: Intrathecal bupivacaine and morphine name: Pericapsular nerve group block plus intrathecal bupivacaine and morphine measure: Morphine consumption measure: Postoperative pain scores measure: The quality of recovery score sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bezmialem Vakif University status: RECRUITING city: Istanbul state: Fatih zip: 34093 country: Turkey lat: 41.01384 lon: 28.94966 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-11-01 uploadDate: 2024-02-03T12:32 filename: Prot_SAP_000.pdf size: 160574 hasResults: False
nctId: NCT06298357 id: 300012601 id: LAIKPRI02012024 type: OTHER_GRANT domain: Kaul Pediatric Research Institute Pilot Grant briefTitle: Virtual Reality Gaming for Exercise and Mindfulness Among Pediatric Cancer Rehabilitation overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-12-31 date: 2026-03-31 date: 2024-03-07 date: 2024-04-03 name: University of Alabama at Birmingham class: OTHER briefSummary: This study will explore the potential benefits of a virtual reality gaming program that focuses on mindfulness and exercise among pediatric cancer rehabilitation patients. The program will last 8 weeks outside of the hospital. Participants will start immediately in the hospital (immediate start group) or wait 8 weeks after hospital discharge to start the program (waitlist control group). conditions: Pediatric Cancer studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: There will be 2 parallel groups, immediate start group and waitlist control group. Once control participants finish the wait period (8 weeks), they will start the intervention (8 weeks). Participants in the immediate start group will start exercise and mindfulness in the hospital and continue the program for 8 weeks outside of the hospital. primaryPurpose: TREATMENT masking: NONE count: 16 type: ESTIMATED name: Immediate Start - Virtual Reality name: Delayed Start - Virtual Reality measure: Physical activity measure: Minutes of gameplay measure: Global Health measure: Forced Expiratory Volume in the first second (FEV1) sex: ALL minimumAge: 8 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Children's Hospital of Alabama city: Birmingham state: Alabama zip: 35233 country: United States lat: 33.52066 lon: -86.80249 hasResults: False