hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06296888 id: P-2022-673 id: 2203718 type: OTHER domain: De Videnskabsetiske Medicinske Komiteer briefTitle: Radiofrequency Balloon Ablation for Atrial Fibrillation: Durability of Pulmonary Vein Isolated and Clinical Outome acronym: RABAAF overallStatus: ACTIVE_NOT_RECRUITING date: 2022-10-01 date: 2024-03-15 date: 2024-08-09 date: 2024-03-06 date: 2024-03-06 name: Jim Hansen class: OTHER name: University Hospital, Gentofte, Copenhagen name: Biosense Webster, Inc. briefSummary: Atrial fibrillation (AF) is the most common heart rhythm disorder affecting 2-4% of the adult human population. AF is a disturbance in the electrical impulses of the heart - an electrical disturbance commonly originating from the pulmonary veins.
Normalization of the heart rhythm with anti-arrhythmic drugs often fail and is frequently associated with side effects. Therefore, a treatment termed ablation by catheters via an inguinal vein has been devised and is increasingly being used for the treatment of AF. The cornerstone of this treatment is electrical isolation of the pulmonary veins so that the nocuous electrical impulses from the pulmonary veins cannot cause a disturbance in the heart rhythm and initiate episodes of AF. This treatment is called pulmonary vein isolation (PVI). Recent studies have shown that PVI is better than anti-arrhythmic drug treatment in the prevention of recurrence of AF, but despite substantial improvements in techniques and tools only 60-70% are cured from AF by a single PVI procedure, and in around 80% of patients who require additional catheter ablation, durable isolation of all the pulmonary veins has not been achieved. Improved tools for durable PVI are therefore required.
In this study, patients with AF referred for catheter ablation will undergo an initial PVI treatment using the radiofrequency balloon catheter. All patients will undergo a repeat electrophysiology (EP) study after 4-6 months to determine to durability of PVI. Patients will be issued with a 48-hour heart rhythm monitor at 3 and 12 months after the initial PVI. Patients-reported effects on quality of life by AF related symptoms will be evaluated using a specialized questionnaire provided approximately every third month throughout the 12 month follow-up. conditions: Atrial Fibrillation studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 45 type: ACTUAL name: Radiofrequency balloon catheter ablation measure: Proportion of durably isolated PVs observed at repeat EP study measure: Proportion of patients with durable isolation of all PVs observed at repeat EP study measure: Proportion of patients remaining free from recurrence of ATA after the initial PVI measure: Difference in the effect of AF related symptoms on quality of life between baseline and after the initial PVI measure: Complications measure: Proportion of patients remaining free from recurrence of ATA after the repeat EP study measure: Difference in the effect of AF related symptoms on quality of life between baseline, after the initial PVI, and after the repeat EP study sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Gentofte Hospital city: Hellerup zip: 2820 country: Denmark lat: 55.73204 lon: 12.57093 hasResults: False
nctId: NCT06296875 id: KAMM briefTitle: The Krill Ageing Muscle Mechanisms (KAMM) Study acronym: KAMM overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-03 date: 2026-03 date: 2024-03-06 date: 2024-03-08 name: University of Glasgow class: OTHER briefSummary: This study aims to determine the mechanisms via which krill oil supplementation increases muscle strength and whether this translates to improvements in gait and functional characteristics in older adults. The studies we will carry out will establish, in healthy older adults, the effects of 6 months of supplementation with krill oil
Objective 3) Gait and functional characteristics Hypothesis: Krill oil supplementation will improve gait and functional characteristics. conditions: Sarcopenia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 1:1 parallel group design primaryPurpose: PREVENTION masking: TRIPLE maskingDescription: All supplements will be matched for taste and look whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Vegetable oil name: Krill oil measure: Grip strength measure: Neuromuscular junction transmission instability measure: Gait speed measure: Knee extensor maximal torque measure: Vastus lateralis muscle cross sectional area measure: Vastus lateralis pennation angle measure: Vastus lateralis fascicle length measure: Erythrocyte fatty acid composition measure: Knee extensor force steadiness measure: Vastus lateralis motor unit conduction velocity measure: Vastus lateralis and vastus medialis intramuscular coherence measure: Hand flexor muscles intermuscular coherence measure: Cortico-muscular coherence between sensory motor cortex and hand extensor muscles measure: Femoral Nerve Stimulation measure: Transcranial Magnetic Stimulation (TMS) measure: TMS Inhibition measure: TMS Excitation measure: Gait characteristics during 4m walk test and the timed up and go test measure: Gait cycle with leg support parameters sex: ALL minimumAge: 65 Years maximumAge: 90 Years stdAges: OLDER_ADULT facility: University of Glasgow city: Glasgow country: United Kingdom lat: 55.86515 lon: -4.25763 hasResults: False
nctId: NCT06296862 id: STUDY00005563 briefTitle: Effect of DASH on HF Outcomes Heart Failure Status in Older Adults (DASH HF) overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-05 date: 2025-06 date: 2024-03-06 date: 2024-03-06 name: University of Georgia class: OTHER name: Emory University briefSummary: The purpose of this study is to examine the effect of the Dietary Approaches to Stop Hypertension (DASH) diet has on heart failure status in older adults. This study is important because it may provide a low-cost strategy to help reduce hospitalizations and deaths for heart failure patients. Participants will be adults age 65 and older with heart failure. They will have 4 study visits, each lasting about 2 hours, and will be in the study for 12 weeks. They will also be asked about their dietary consumption 6 times, each time lasting about 45 minutes. All in-person study visits will take place in the Emory GCRC. Participants will have physical exams, body measurements, blood tests, urinalysis, chart review, and answer surveys. They will be randomized to eat only the DASH diet provided to them for 4 weeks either at the beginning or end of their participation in the study. Participants will be recruited from heart failure patients at Emory University Hospital, Emory University Hospital Midtown, and Emory Outpatient Advanced Heart Failure Therapy Center. The total enrollment planned under Emory's oversight, accounting for screen failures and withdrawals, will be n=38 participants. The study team will obtain informed consent prior to the first study visit either in person, or, alternatively, over the phone, if requested by participants. Specimens and data obtained in this study will not be banked for future use. conditions: Heart Failure studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 38 type: ESTIMATED name: Dietary Approaches to Stop Hypertension Diet measure: B-natriuretic peptide (BNP) measure: N-terminal-proBNP (NT-proBNP) measure: Systolic and Diastolic Pulmonary Artery Pressures sex: ALL minimumAge: 65 Years maximumAge: 110 Years stdAges: OLDER_ADULT facility: Emory Clinical Cardiovascular Research Center (ECCRI) city: Atlanta state: Georgia zip: 30322 country: United States name: Arshed A Quyyumi, MD, PhD role: CONTACT phone: 404-727-6635 email: quyyum@emory.edu lat: 33.749 lon: -84.38798 hasResults: False
nctId: NCT06296849 id: 00007344 briefTitle: Dyadic Financial Incentive Treatments for Dual Smoker Couples overallStatus: RECRUITING date: 2024-01-18 date: 2028-05 date: 2028-05 date: 2024-03-06 date: 2024-03-12 name: University of Georgia class: OTHER name: McMaster University name: University of Kentucky briefSummary: Smokers partnered with other smokers (i.e., dual-smoker couples) represent \~2/3 of all smokers. Dual-smoker couples (DSCs) are less likely to try to quit smoking and more likely to relapse during a quit attempt, reducing overall smoking cessation rates and representing a high-risk clinical population. Despite their high prevalence and risk for persistent smoking, however, there are limited data on smoking cessation interventions among DSCs. Building on previous research that suggests a) financial incentive treatments (FITs) are effective at increasing quit rates and b) dyadic adaptations of FITs are feasible for implementation in DSCs, the proposed study will systematically two versions of FITs to enhance smoking cessation among DSCs. In addition to determining the efficacy of these dyadic FITs for smoking abstinence in DSCs, the investigators will consider the cost and cost effectiveness of each adaptation as well as mechanisms of change to inform future implementation research. The investigators will additionally consider secondary outcomes including abstinence during treatment and long-term abstinence maintenance after end of treatment.
The investigators will address these questions in a three-group randomized controlled trial (RCT). In all conditions, individuals who have smoking partners (i.e., targets) will receive usual care (combination fast and slow acting Nicotine Replacement Therapy + quitting resources). In two conditions, participants will receive incentives for abstinence at three time points (1, 3, and 6 months post-baseline). In the SFIT condition, only the target in a couple will be offered incentives; in the DFIT condition, both target and partner will be offered incentives. Primary efficacy outcome is % point-prevalence abstinence at 6 months post-baseline among targets. Secondary outcomes are point-prevalence abstinence at 1 and 3 months during the treatment and 6 months post-treatment (12-months post-baseline), as well as partner outcomes. The investigators will evaluate possible mechanisms of change including partner support and individual and partner motivation to quit as well as evaluate the cost and relative cost of each abstainer within and across condition. These data on the efficacy, mechanisms, and costs of FITs for DSCs will inform population level implementation and promote successful quitting in this treatment refractory population. conditions: Smoking, Cigarette studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 900 type: ESTIMATED name: Financial Incentive Treatment (FIT) measure: Point-Prevalence Abstinence at End of Treatment measure: Point-Prevalence Abstinence After Treatment measure: Point-Prevalence Abstinence at First Follow-up measure: Point-Prevalence Abstinence at Second Follow-up measure: Partner Point-Prevalence Abstinence measure: Smoking Heaviness sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Georgia status: RECRUITING city: Athens state: Georgia zip: 30602 country: United States name: Michelle R vanDellen, PhD role: CONTACT email: mvd@uga.edu lat: 33.96095 lon: -83.37794 hasResults: False
nctId: NCT06296836 id: 2024-001 briefTitle: Effect of Continuing Versus Holding Metformin During Hospitalizations. overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-03-31 date: 2026-06-30 date: 2024-03-06 date: 2024-03-06 name: University of Illinois at Chicago class: OTHER name: Emily Hanners name: Dulal Bhaumik name: Avisek Datta name: Peggy Choye name: Hailey Soni name: Annesti Elmasri name: Julie Jun name: Colin Goodman briefSummary: A randomized study of continuing versus holding metformin during hospitalizations to internal medicine services to determine the effects on glucose control, acidosis, abdominal symptoms, length of stay, and mortality. conditions: Diabetes Mellitus, Type 2 studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized, parallel, prospective trial. primaryPurpose: TREATMENT masking: NONE count: 300 type: ESTIMATED name: Metformin measure: Mean glucose levels measure: Incidence of hyperglycemia greater than 300 mg/dl. measure: Incidence of hypoglycemia (Glu = 54 - 70). measure: Incidence of moderate hypoglycemia (Glu < 54) measure: Incidence of severe hypoglycemia (Glu < 54 with symptoms) measure: Mean lactic acid levels. measure: Incidence of lactic acid levels greater than 2.0. measure: Mean anion gap. measure: Incidence of anion gap > 11 measure: Incidence of elevated lactic acid level or anion gap. measure: Incidence of inadvertently not continuing metformin on discharge measure: GI adverse effects measure: Mortality measure: Mean glucose levels while receiving metformin in the continuation arm and while not receiving metformin in the discontinuation arm sex: ALL minimumAge: 18 Years maximumAge: 110 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Illinois at Chicago city: Chicago state: Illinois zip: 60612 country: United States lat: 41.85003 lon: -87.65005 hasResults: False
nctId: NCT06296823 id: 22-0466 briefTitle: Biomarkers for Peripheral Circadian Clocks in Humans overallStatus: RECRUITING date: 2023-09-01 date: 2027-08-31 date: 2027-08-31 date: 2024-03-06 date: 2024-03-06 name: University of Colorado, Boulder class: OTHER name: University of Colorado, Denver briefSummary: The purpose of this project is to improve our understanding of peripheral circadian rhythms in humans. Circadian clocks are present in most tissues of the body with importance for optimal physiological function, health, and behavior. This project will utilize simulated jetlag protocols to systematically test novel hypotheses about the regulation of peripheral circadian rhythms in humans. Specifically, we will examine how changes in the time of when we are exposed to light and the timing of when we eat impacts proteins in the blood and saliva that represent rhythms from clocks in the brain (e.g., rhythms of the hormones melatonin and cortisol coordinated by the brain) and rhythms from clocks in body tissues (e.g., proteins made by immune and bone cells, and cells in the stomach and liver). We also aim to discover new blood-based biomarkers of peripheral rhythms in humans. We anticipate our findings will be the first step in developing novel circadian based treatments for aligning peripheral clocks under conditions such as jetlag, and for developing novel circadian biomarkers that will advance our scientific understanding of circadian rhythms. conditions: Circadian Rhythms studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: NONE count: 14 type: ESTIMATED name: Simulated jetlag protocol measure: PYY measure: Ghrelin measure: Leptin measure: CRP measure: OMD measure: PAI-1 measure: IgE measure: CCL18 measure: PTH measure: Glucose measure: Insulin measure: Proteomics measure: Melatonin measure: Cortisol measure: Core body temperature measure: Skin temperature measure: Cognition measure: Blood pressure measure: Metabolomics (grant application planned to analyze not currently funded) measure: Oral microbiome (grant application planned to analyze not currently funded) measure: Skin microbiome (grant application planned to analyze not currently funded) sex: ALL minimumAge: 17 Years maximumAge: 35 Years stdAges: CHILD stdAges: ADULT facility: Sleep and Chronobiology Laboratory status: RECRUITING city: Boulder state: Colorado zip: 80303 country: United States name: Kenneth Wright role: CONTACT phone: 303-735-1923 email: sleep.study@colorado.edu lat: 40.01499 lon: -105.27055 hasResults: False
nctId: NCT06296810 id: 23-0847 briefTitle: Adaptive DBS to Offset STN Dysregulation During Exercise in PD overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-12 date: 2025-12 date: 2024-03-06 date: 2024-03-06 name: University of Colorado, Denver class: OTHER briefSummary: The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator. conditions: Parkinson Disease studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 10 type: ESTIMATED name: aDBS measure: identification of L-beta frequency peak power sex: ALL minimumAge: 20 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06296797 id: 5R18HS029432-02 type: AHRQ link: https://reporter.nih.gov/quickSearch/5R18HS029432-02 id: R18HS029432 type: AHRQ link: https://reporter.nih.gov/quickSearch/R18HS029432 briefTitle: Patient-centered Information on Permanent Contraception overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-04-01 date: 2024-03-06 date: 2024-03-06 name: University of California, San Francisco class: OTHER name: Essential Access Health name: Agency for Healthcare Research and Quality (AHRQ) briefSummary: The goal of this study is to understand whether providing information to women with a strong desire to avoid future pregnancy about how tubal sterilization compares to long-acting reversible contraceptives improves perceived access to available contraceptives.
The investigators will compare outcomes among participants provided with access to a new website (intervention) summarizing recent patient-centered outcomes research (PCOR) comparing interval laparoscopic tubal sterilization and long-acting reversible contraception (LARC) to control participants provided with access to the existing Planned Parenthood website on tubal sterilization. conditions: Contraception conditions: Reproductive Behavior conditions: Contraception Behavior studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: DOUBLE whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 350 type: ESTIMATED name: Control arm: Existing educational website name: Advancing Access Website measure: Perceived Access to Long Acting Contraceptives measure: Person-Centered Contraceptive Counseling Measure measure: Consumer Assessment of Healthcare Providers and Systems measure: Patients' Perceived Efficacy in Patient-Physician Interactions (PEPPI) measure: Knowledge of Long-Acting Contraceptives measure: Use of preferred method of contraception measure: Would recommend website to a friend measure: Suggestions for how to improve web-based resources for people considering permanent contraception. sex: FEMALE minimumAge: 21 Years maximumAge: 45 Years stdAges: ADULT facility: University of California, San Francisco city: San Francisco state: California zip: 94143 country: United States name: Eleanor Schwarz, MD, MS role: CONTACT email: eleanor.schwarz@ucsf.edu name: Hannah Begna, MS role: CONTACT email: hannah.begna@ucsf.edu lat: 37.77493 lon: -122.41942 hasResults: False
nctId: NCT06296784 id: PG/2021/8551 briefTitle: An E-health Psychoeducation for People With Bipolar Disorders overallStatus: COMPLETED date: 2021-05-26 date: 2021-11-15 date: 2021-11-15 date: 2024-03-06 date: 2024-04-05 name: University of Cagliari class: OTHER name: Alessandra Perra briefSummary: This study aims to present data on the improvement of Quality of life (QoL), biological rhythms, anxiety, depressive symptoms and the correlations between QoL and biorhythms following an e-health psychoeducational intervention for Bipolar Disoirder (BD) during Covid-19 pandemic conditions: Bipolar Disorder conditions: Psychoeducation conditions: COVID-19 Pandemic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Open-label cross-over randomized controlled trial (two arms) primaryPurpose: TREATMENT masking: NONE count: 36 type: ACTUAL name: e-health psychoeducation measure: Generalized Anxiety Disorder (GAD-7) measure: Hamilton Depression Rating Scale (HDRS21) measure: Short Form Health Survey (SF-12) measure: Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: San Giovanni di Dio Hospital city: Cagliari state: CA zip: 09100 country: Italy lat: 39.23054 lon: 9.11917 hasResults: False
nctId: NCT06296771 id: 12345678280233 id: UBath type: REGISTRY domain: Chatwalai briefTitle: The Effect of a Combined Aerobic and Resistance Exercise (CARE) Training Programme on Cardiometabolic Outcomes in Individuals With Chronic Spinal Cord Injury: A Randomised Controlled Trial acronym: CARE training overallStatus: NOT_YET_RECRUITING date: 2024-05-22 date: 2025-02-22 date: 2025-05-22 date: 2024-03-06 date: 2024-03-06 name: University of Bath class: OTHER briefSummary: The goal of this study is to investigate the effectiveness of an 8-week dietary energy restriction with exercise or dietary energy restriction alone on the cardiometabolic health outcomes of individuals with chronic spinal cord injury. This study is a randomised controlled trial conducted at a single centre, consisting of two parallel arms. The main questions it aims to answer are:
Twenty-one participants will be randomly assigned in a 2:1 allocation ratio. The participants will be assigned to either the dietary energy restriction and exercise group (D+E) group, which combines dietary energy restriction and exercise intervention, or the dietary energy restriction group (D) group, which just undergoes dietary energy restriction using sealed envelopes. conditions: Spinal Cord Injury studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 21 type: ESTIMATED name: Dietary energy restriction group (D) name: Dietary energy restriction and exercise group (D+E) measure: Lipid profile measure: Fasting insulin concentration measure: Insulin sensitivity measure: Resting matabolic rate measure: Body mass measure: Waist and hip circumference measure: Height measure: Total body fat percentage measure: Total Fat-Free Mass measure: Visceral Adipose Tissue measure: Total Fat Mass measure: Muscle, adipose and bone cross-sectional areas around the tibia and femur measure: Bone geometry and tissue densities around the tibia and femur measure: adipose tissue measure: Upper extremity muscle strength measure: Balance measure: Health-related quality of life measure: Shoulder Pain measure: Energy intake and dietary macronutrient composition measure: Energy expended in different physical activity intensities (MET categories) (kJ or kcal) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Bath city: Bath state: England zip: BA2 7AY country: United Kingdom name: James Bilzon, PhD role: CONTACT email: jb438@bath.ac.uk name: Jennifer Maher, PhD role: CONTACT email: jilm92@bath.ac.uk name: Chatwalai Sonthikul, Master degree role: PRINCIPAL_INVESTIGATOR lat: 51.3751 lon: -2.36172 hasResults: False