hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06362863 id: WDRY2024-K027 briefTitle: Evaluation of Enteral Nutrition Biscuits for Inducing Remission in Moderate-to-severe Crohn's Disease overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2025-12 date: 2024-04-12 date: 2024-04-12 name: Ping An class: OTHER briefSummary: By conducting a randomized controlled study of the role of enteral nutrition biscuits in the induction of remission in moderate-to-severe Crohn's disease, we will evaluate to investigate the role of enteral nutrition biscuits in the induction and remission phases of moderate-to-severe Crohn's disease; to assess patient adherence to enteral nutrition biscuits and the timing of their application; to assess the role of enteral nutrition biscuits in biologically refractory patients; and to assess the role of enteral nutrition biscuits in the remission of perianal, small bowel, and colonic lesions. conditions: Crohn's Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a prospective randomized controlled study divided into intervention and control groups. primaryPurpose: TREATMENT masking: NONE count: 52 type: ESTIMATED name: enteral nutrition biscuits measure: Crohn's disease activity index, CDAI measure: Induced remission success rate measure: Gastrointestinal Symptom Rating Scale (GSRS) score measure: Gastrointestinal symptom remission measure: Detection of antibody levels to the biologics used in sera from patients with secondary loss of response to the biologics measure: Incidence and severity of perianal lesions in both groups measure: Rate of endoscopic remission of small bowel and colon lesions in both groups measure: Changes in inflammatory biomarkers (C-reactive protein, fecal calreticulin) in both groups measure: Adverse events and serious adverse events, safety and tolerability, with treatment-related adverse events and number of occurrences as assessed by CTCAE v5.0 sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362850 id: 1253/2023 briefTitle: Tele-Support for Emergency Medical Technicians acronym: POHCA overallStatus: RECRUITING date: 2024-04-08 date: 2024-04-18 date: 2024-12-01 date: 2024-04-12 date: 2024-04-12 name: Medical University of Vienna class: OTHER name: Ludwig Boltzmann Institute Digital Health and Patient Safety briefSummary: In this manikin-based simulation study the impact of tele-support during a simulated pediatric out-of-hospital cardiac arrest scenario on emergency medical technicians' guideline adherence, on gaze behavior as well as on performance of resuscitation management and cognitive load will be analyzed. conditions: Cardiac Arrest studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: In a manikin-based simulation study, the participants will be randomized to either performing the scenario with tele-support or without tele-support (80 participants 40 groups, 20 groups with tele-support, 20 groups without tele-support). primaryPurpose: OTHER masking: NONE count: 80 type: ESTIMATED name: Tele-support measure: guideline adherence measure: gaze behavior measure: teamwork performance measure: cognitive load measure: Performance of cardiopulmonary resuscitation measure: Technical feasibility measure: Usability sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Anesthesia, General Intensive Care and Pain Management,Medical University of Vienna status: RECRUITING city: Vienna zip: 1090 country: Austria name: Christina Hafner, MD, PhD role: CONTACT phone: 004314040041020 email: christina.hafner@meduniwien.ac.at lat: 48.20849 lon: 16.37208 hasResults: False
nctId: NCT06362837 id: P0117910-001 briefTitle: Evaluation of REACTS-IN, an Intervention to Improve Nutrition, Hygiene, and Sexual and Reproductive Health Services acronym: REACTS-IN overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2029-06-30 date: 2030-05-24 date: 2024-04-12 date: 2024-04-12 name: McGill University class: OTHER name: World Vision Canada name: Global Affairs Canada briefSummary: This is an independent evaluation of World VIsion's 7-year quasi-experimental intervention to improve nutrition, nutrition-related rights and gender equality for women, adolescent girls, and children under five years of age in rural Bangladesh, Kenya, and Tanzania. The evaluation will collect baseline, midline, and end-line data from intervention and comparison communities, schools, and health facilities. The evaluation objectives are to test if the intervention improved indicators for (i) child anthropometry, (ii) maternal and child dietary practices, (iii) women's empowerment, and (iv) equitable health service access for nutrition and sexual and reproductive needs. The evaluation analysis will take into account gender differences in the indicators. conditions: Stunting conditions: Gender Equality conditions: Acceptability of Health Care conditions: Diet; Deficiency conditions: Empowerment studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a quasi-experimental design for the evaluation of an intervention that is in the community (including schools) as well as in the local health service facilities. The data collection at baseline, midline, and end-line will occur simultaneously in the intervention and comparison selected communities. primaryPurpose: OTHER masking: NONE count: 13500 type: ESTIMATED name: Education intervention on nutrition, gender equity, WASH, sexual and reproductive health rights name: school-based iron-folic acid supplement program name: Health service training on equitable access to nutrition, health, and sexual and reproductive services name: bio-fortified crops measure: Gender equality measure: Child anthropometry measure: Antenatal care measure: Contraception use by women and partners measure: Child diet measure: Sexual and reproductive health services for adolescents measure: Gender equitable health services for nutrition, health, and sexual and reproductive health sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Brac University city: Dhaka country: Bangladesh name: Malay K Mridha, PhD role: CONTACT email: malay.mridha@bracu.ac.bd lat: 23.7104 lon: 90.40744 facility: Connar Consultants city: Nairobi country: Kenya name: Elizabeth Kamau, PhD role: CONTACT email: ekambu@gmail.com lat: -1.28333 lon: 36.81667 facility: Ifakara Health Institute city: Ifakara country: Tanzania name: Ester Elisaria, PhD role: CONTACT email: eelisaria@ihi.or.tz lat: -8.13333 lon: 36.68333 hasResults: False
nctId: NCT06362824 id: 2094138 briefTitle: Promoting Physical Activity in Older Hispanic/Latino(a) Adults overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2028-09-30 date: 2029-09-30 date: 2024-04-12 date: 2024-04-15 name: Kaiser Permanente class: OTHER name: University of California, San Diego briefSummary: In this randomized controlled trial, study staff will randomize 130 Hispanic/Latino adults without dementia and over age 55 from Southern California to either the culturally adapted De Pie physical activity intervention or an active comparison program focusing on general brain health topics. The purpose of this study is to determine if 12 weeks of the culturally adapted and fully remote De Pie y a Movernos intervention improves self-efficacy, habit strength, social support, and enjoyment for physical activity (PA), thus promoting adherence to moderate-intensity physical activity (MIPA) guidelines (150 minutes/week). conditions: Sedentary Behavior conditions: Physical Inactivity conditions: Alzheimer Disease, Protection Against studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 130 type: ESTIMATED name: De Pie Intervention name: Active Comparison Group: Healthy Actions And Lifestyles To Avoid Dementia (HALT-AD) measure: Change in Moderate Intensity Physical Activity (MIPA) minutes/day measure: Meet MIPA guidelines of 150 minutes physical activity per week sex: ALL minimumAge: 55 Years maximumAge: 89 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of California San Diego city: San Diego state: California zip: 92093 country: United States name: Zvinka Z Zlatar, PhD role: CONTACT email: zzlatar@health.ucsd.edu name: Zvinka Z Zlatar, PhD role: PRINCIPAL_INVESTIGATOR lat: 32.71533 lon: -117.15726 hasResults: False
nctId: NCT06362811 id: 483730 briefTitle: Assessment of Efficacy of Sacral Erector Spinae Plane Block for Postoperative Analgesia in Pediatric Rectal Biopsies overallStatus: COMPLETED date: 2023-01-01 date: 2023-12-31 date: 2023-12-31 date: 2024-04-12 date: 2024-04-16 name: Istanbul University class: OTHER briefSummary: The purpose of this study is to evaluate how sacral erector spinae block changed the postoperative analgesia requirements in pediatric patients undergoing rectal biopsies under general anesthesia. conditions: Analgesia conditions: Pain, Acute studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 48 type: ACTUAL name: Sacral Erector Spinae Plane Block measure: Postoperative pain scores measure: Analgesia requirement measure: Complications sex: ALL minimumAge: 1 Day maximumAge: 5 Years stdAges: CHILD facility: Istanbul University Cerrahpasa city: Istanbul zip: 34098 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06362785 id: Virtual Reality-Seniors briefTitle: Musculoskeletal Pain, Motor Control, Risk of Falls and Virtual Reality overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-06 date: 2026-06 date: 2024-04-12 date: 2024-04-12 name: Universidade da Coruña class: OTHER name: Centre for Information and Communications Technology Research (CITIC) briefSummary: The goal of this clinical trial is to learn about musculoskeletal pain, functionality, and risk of falls in community-dwelling adults aged 60 years and older. The main questions it aims to answer are:
Researchers will compare community-dwelling adults aged 60 years and older who execute task based exercises in a virtual environment through virtual reality and community-dwelling adults aged 60 years and older without any intervention to see if virtual reality improves musculoskeletal pain, functionality, and lowers fall risk. conditions: Musculoskeletal Pain conditions: Task Performance and Analysis conditions: Accidental Falls conditions: Virtual Reality studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 110 type: ESTIMATED name: Virtual Reality measure: Presence of musculoskeletal pain measure: Pain Intensity measure: Initial positioning measure: Final positioning measure: Angular velocity measure: Acceleration measure: Movement execution time measure: Range of joint movement measure: Neck disability measure: Lower back disability measure: Kinesiophobia measure: Falls history measure: General health status measure: Date of birth measure: Gender measure: Height measure: Weight measure: Body mass index (BMI) measure: Depressive symptoms measure: Cognitive capacity measure: Amount and type of medication consumed measure: Existence of comorbidity sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362772 id: MR-36-24-010944 briefTitle: Clinical Efficacy of 125I Seed Implantation in the Treatment of Refractory Differentiated Thyroid Cancer overallStatus: COMPLETED date: 2015-01-01 date: 2022-02-01 date: 2023-04-01 date: 2024-04-12 date: 2024-04-12 name: Jiangxi Provincial Cancer Hospital class: OTHER briefSummary: A retrospective analysis was conducted on RAIR-DTC patients who underwent radioactive 125I seed implantation from January 2015 to February 2022 at Jiangxi Cancer Hospital. Prescription dose: 80\~120 Gy. All cases were followed up at 1, 3, and 5 months postoperatively to monitor changes in tumor size, serum thyroglobulin (Tg), and serum anti-thyroglobulin antibody levels in thyrotropin-inhibited states, pain scores, and postoperative adverse reactions. The data were processed and analyzed using IBM SPSS 26.0. Pairwise comparisons were conducted using the Wilcoxon signed-rank test, and a p-value of less than 0.05 indicated statistical significance. conditions: Thyroid Neoplasms studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 36 type: ACTUAL name: Iodine-125 brachytherapy measure: Tumor size measure: Serological assessment measure: Pain score measure: Adverse event sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362759 id: TOUR006-C01 briefTitle: A Study to Evaluate TOUR006 in Patients With Chronic Kidney Disease and Elevated Hs-CRP acronym: TRANQUILITY overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-05 date: 2026-02 date: 2024-04-12 date: 2024-04-12 name: Tourmaline Bio, Inc. class: INDUSTRY briefSummary: This study will evaluate the safety, tolerability, pharmacokinetics, and CRP-lowering effect of quarterly and monthly subcutaneous administration of TOUR006 in participants with chronic kidney disease and elevated hs-CRP. conditions: Chronic Kidney Diseases conditions: Chronic Kidney Insufficiency conditions: Chronic Renal Diseases conditions: Chronic Renal Insufficiency conditions: Kidney Insufficiency, Chronic conditions: C-Reactive Protein conditions: High Sensitivity C-Reactive Protein conditions: Hs-CRP conditions: hsCRP studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: TOUR006 - 50 MG name: TOUR006 - 25 MG name: TOUR006 - 15 MG name: Placebo measure: Evaluate the effects of TOUR006 compared with placebo on hs-CRP measure: Evaluate the effects of TOUR006 compared with placebo on hs-CRP measure: Evaluate the pharmacokinetics by measuring serum concentrations of TOUR006 measure: Evaluate the safety and tolerability of TOUR006 in participants with elevated cardiovascular risk and CKD sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362746 id: FORPE-2 briefTitle: Non-immunogenic Recombinant Staphylokinase vs Placebo in Patients With Intermediate High-risk Pulmonary Embolism overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2028-06-01 date: 2028-12-01 date: 2024-04-12 date: 2024-04-12 name: Supergene, LLC class: INDUSTRY briefSummary: Objective: to evaluate the efficacy and safety of the non-immunogenic recombinant staphylokinase with its single bolus administration in comparison with placebo in normotensive patients with intermediate high-risk pulmonary embolism (PE) conditions: Pulmonary Embolism studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: At clinical sites patients will be equally randomized into two groups to receive non-immunogenic recombinant staphylokinase or placebo.
nctId: NCT06362733 id: IRB-74165 briefTitle: Modified Pivotal Response Treatment for Insistence on Sameness in Autistic Youth overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-06-01 date: 2026-06-01 date: 2024-04-12 date: 2024-04-12 name: Stanford University class: OTHER briefSummary: The purpose of this open label trial is to examine the preliminary effectiveness of a 12-week behavioral intervention program (1 hour/week) to treat insistence on sameness (e.g., difficulty tolerating changes in routine) in youth with autism spectrum disorder (ASD). Treatment will be delivered via secure telemedicine platform and consist of a combination of parent-training and child-focused intervention. conditions: Autism Spectrum Disorder conditions: Restricted Behavior conditions: Autism studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 44 type: ESTIMATED name: Modified Pivotal Response Treatment for Insistence on Sameness in Autistic Youth measure: Change from Baseline in Insistence on Sameness Subscale of the Dimensional Assessment of Restricted and Repetitive Behaviors (DARB). measure: Change from Baseline on Blinded Clinician Ratings of Clinical Global Impression Scale, Severity and Improvement Ratings. measure: Change from Baseline in Parent-Rated Emotion Dysregulation on the Strengths and Difficulties Questionnaire Dysregulation Profile (SDQ-DP) during treatment. measure: Change from Baseline in Parent-Rated Irritability as captured by the Aberrant Behavior Checklist (ABC), Irritability Subscale. measure: Change from Baseline in Ritualistic/Sameness Subscale of Repetitive Behavior Scale-Revised (RBS-R). measure: Change from Baseline in Parent-Rated Challenging Behaviors on the Open-Source Challenging Behaviors Scale (OS-CBS). measure: Change from Baseline in Parent-Rated Anxiety as captured by the Anxiety Scale for Children with Autism Spectrum Disorder (ASC-ASD). measure: Change from Baseline in Caregiver Self-Report on the Caregiver Strain Questionnaire Short Form (CGSQ-SF7). measure: Change from Baseline in Caregiver Self-Report on the Warwick-Edinburg Mental Wellbeing Scales (WEMWS). measure: Change from Baseline in the Caregiver Self-Report Depression, Anxiety, and Stress Scale (DASS21). measure: Caregiver Report Autism Symptoms Dimension Questionnaire (ASDQ). measure: Caregiver Report Executive Functioning Scale (EFS). measure: Daily Living Skills Scale (DLSS). sex: ALL minimumAge: 4 Years maximumAge: 17 Years stdAges: CHILD hasResults: False
nctId: NCT06362720 id: 720/2566(IRB2) briefTitle: The Comparison the CMV Infection and Reactivation After Allogeneic Hematopoietic Stem Cell Transplantation Between Standard Regimen, Methotrexate Plus Cyclosporin A, and Post-transplant Cyclophosphamide-based Regimen acronym: CMV overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-10-31 date: 2024-12-31 date: 2024-04-12 date: 2024-04-12 name: Siriraj Hospital class: OTHER briefSummary: The goal of this observational study is to compare the CMV infection and reactivation after allogeneic hematopoietic stem cell transplantation Between Standard Regimen, Methotrexate plus Cyclosporin A, and Post-transplant Cyclophosphamide-based Regimen. The main questions it aims to answer are:
* Averse events of GVHD prophylaxis medication Participants will be collected the data of treatment and treatment response during transplant until 2 years after transplant from hospital medical record. conditions: CMV Infection or Reactivation After Allogenic HSCT studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 158 type: ESTIMATED measure: Number of participants with CMV infection and reactivation measure: progression-free survival measure: Median overall survival measure: cumulative incidence of relapse measure: non-relapsed mortality measure: GvHD measure: Averse events sex: ALL minimumAge: 15 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362707 id: 2023161001 briefTitle: Fasudil Trial for Treatment of Early Alzheimer's Disease (FEAD) acronym: FEAD overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-10-01 date: 2026-10-01 date: 2024-04-12 date: 2024-04-15 name: Helse Stavanger HF class: OTHER_GOV name: University of Exeter briefSummary: The goal of this placebo-controlled double-blind Phase 2 clinical trial is to test in people with early Alzheimer's Disease.
The study will compare participants receiving fasudil with those receiving placebo to see if fasudil treatment leads to improvements in cognitive functions, brain metabolism measured by FDG-PET. conditions: Cognitive Decline, Mild conditions: Alzheimer Disease studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 200 type: ESTIMATED name: Fasudil name: Placebo measure: Cognition measure: Brain metabolism measure: Plasma levels of ptau217 measure: Plasma levels of nfl measure: Levels of cerebrospinal Aβ1-40 and Aβ1-42 measure: Levels of cerebrospinal tau and p-tau measure: Blood pressure (Safety assessments) measure: Pulse (Safety assessments) measure: Urine testing (Safety assessments) measure: Blood urea nitrogen (BUN) (Safety assessments) measure: Potassium (Safety assessments) measure: Sodium (Safety assessments) measure: Calcium (Safety assessments) measure: Glucose (Safety assessments) measure: Hemoglobin (Safety assessments) measure: Creatinine (Safety assessments) measure: Total and direct bilirubin (Safety assessments) measure: CRP (C-reactive protein) (Safety assessments) measure: Aspartate aminotransferase (AST) (Safety assessments) measure: Serum glutamic-oxaloacetic transaminase (SGOT) (Safety assessments) measure: Alanine aminotransferase (ALT) (Safety assessments) measure: Serum glutamic-pyruvic transaminase (SGPT) (Safety assessments) measure: Alkaline phosphatase (Safety assessments) measure: Electrocardiogram (ECG) (Safety assessments) measure: Columbia Suicide Severity Rating Scale (C-SSRS) (Safety assessments) sex: ALL minimumAge: 50 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362694 id: 34 briefTitle: Study of the Rechallenge Concept in Patients With BRAF-positive Anaplastic Thyroid Cancer After Progression on Anti-BRAF Therapy overallStatus: RECRUITING date: 2024-03-25 date: 2026-03-25 date: 2026-06-25 date: 2024-04-12 date: 2024-04-12 name: Saint Petersburg State University, Russia class: OTHER briefSummary: This pilot phase 2 study evaluates the effectiveness and safety of the Rechallenge concept in patients with BRAF-positive anaplastic thyroid cancer after progression on anti-BRAF therapy. Patients with BRAF-positive anaplastic thyroid cancer who were previously treated with dabrafenib and trametinib (with a clinical or objective response at the start of treatment) and later with tumor progression during anti-BRAF therapy and subsequent lines of chemotherapy are scheduled to undergo targeted therapy (repeated administration of dabrafenib and trametinib in standard doses) and evaluate the outcomes according to the primary and secondary endpoints. conditions: Anaplastic Thyroid Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: Dabrafenib + Trametinib measure: Objective response rate measure: Progression-Free Survival measure: Safety and Tolerability assessment (Incidence of Treatment-Emergent Adverse Events) measure: Overall survival measure: The assessment of conversion to resectability sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Saint Petersburg State University Hospital status: RECRUITING city: Saint Petersburg zip: 190020 country: Russian Federation name: Ernest Dzhelialov role: CONTACT phone: +7(911)134-50-44 email: ernest.dzhelialov@gmail.com lat: 59.93863 lon: 30.31413 hasResults: False