nctId: NCT06388187 id: NN9838-7749 id: U1111-1298-3451 type: OTHER domain: World Health Organization (WHO) id: 2023-509273-24 type: OTHER domain: European Medical Agency (EMA) briefTitle: A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight overallStatus: NOT_YET_RECRUITING date: 2024-06-24 date: 2026-02-27 date: 2026-04-10 date: 2024-04-29 date: 2024-04-29 name: Novo Nordisk A/S class: INDUSTRY briefSummary: This study will look at how well CagriSema helps people with excess body weight lose weight. CagriSema is a new medicine developed by Novo Nordisk that combines cagrilintide and semaglutide. CagriSema cannot yet be prescribed by doctors. In the study, participant will either get CagriSema or dummy medicine and which treatment participant get is decided by chance. The study will last for about 1½ years for each participant. conditions: Obesity studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 300 type: ESTIMATED name: Cagrilintide name: Semaglutide name: Placebo measure: Relative change in body weight measure: Achievement of ≥5% weight reduction measure: Achievement of ≥10% weight reduction measure: Achievement of ≥15% weight reduction measure: Achievement of ≥20% weight reduction measure: Change in waist circumference measure: Change in systolic blood pressure measure: Ratio to baseline in lipids: Total cholesterol measure: Ratio to baseline in lipids: High-density lipoprotein (HDL) cholesterol measure: Ratio to baseline in lipids: Low-density lipoprotein (LDL) cholesterol measure: Ratio to baseline in lipids: Very low-density lipoprotein (VLDL) cholesterol measure: Ratio to baseline in lipids: Triglycerides measure: Ratio to baseline in lipids: Free fatty acids sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Aurora FDRC Inc. city: Costa Mesa state: California zip: 92627 country: United States lat: 33.64113 lon: -117.91867 facility: Clinical Trial Res Assoc,Inc city: Plantation state: Florida zip: 33324 country: United States lat: 26.13421 lon: -80.23184 facility: Midwest Inst For Clin Res city: Indianapolis state: Indiana zip: 46260 country: United States lat: 39.76838 lon: -86.15804 facility: Accellacare city: Wilmington state: North Carolina zip: 28401 country: United States lat: 34.22573 lon: -77.94471 facility: Velocity Clinical Res-Dallas city: Dallas state: Texas zip: 75230 country: United States lat: 32.78306 lon: -96.80667 facility: Washington Cntr Weight Mgmt city: Arlington state: Virginia zip: 22206 country: United States lat: 38.88101 lon: -77.10428 facility: Capital Clin Res Ctr,LLC city: Olympia state: Washington zip: 98502 country: United States lat: 47.03787 lon: -122.9007 facility: Ocean West Research Clinic city: Surrey state: British Columbia zip: V3Z 2N6 country: Canada lat: 49.10635 lon: -122.82509 facility: Nova Scotia Health Authority city: Halifax state: Nova Scotia zip: B3H 1V7 country: Canada lat: 44.64533 lon: -63.57239 facility: Wharton Med Clin Trials city: Hamilton state: Ontario zip: L8L 5G8 country: Canada lat: 43.25011 lon: -79.84963 facility: Hospices Civils de Lyon-Hopital Lyon Sud-1 city: Pierre-Benite zip: 69310 country: France lat: 45.7009 lon: 4.82511 facility: Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec-1 city: Saint Herblain zip: 44800 country: France lat: 47.21765 lon: -1.64841 facility: Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1 city: Toulouse Cedex 9 zip: 31059 country: France lat: 43.60426 lon: 1.44367 facility: InnoDiab Forschung GmbH city: Essen zip: 45136 country: Germany lat: 51.45657 lon: 7.01228 facility: Wendisch/Dahl Hamburg city: Hamburg zip: 22607 country: Germany lat: 53.57532 lon: 10.01534 facility: AmBeNet GmbH city: Leipzig zip: 04107 country: Germany lat: 51.33962 lon: 12.37129 facility: Institut für Diabetesforschung GmbH Münster - Dr. med. Rose city: Münster zip: 48145 country: Germany lat: 51.96236 lon: 7.62571 facility: Forschungszentrum Ruhr KliFoCenter GmbH, Dr. med. Kahrmann city: Witten zip: 58455 country: Germany lat: 51.44362 lon: 7.35258 facility: The Health Centre city: Bradford-on-Avon zip: BA15 1DQ country: United Kingdom lat: 51.34772 lon: -2.25065 facility: Southmead Hospital city: Bristol zip: BS10 5NB country: United Kingdom lat: 51.45523 lon: -2.59665 facility: Addenbrooke's Hospital_Cambridge city: Cambridge zip: CB2 0QQ country: United Kingdom lat: 52.2 lon: 0.11667 facility: WISDEM Centre city: Coventry zip: CV2 2DX country: United Kingdom lat: 52.40656 lon: -1.51217 facility: The Staploe Medical Centre city: Soham zip: CB7 5JD country: United Kingdom lat: 52.33543 lon: 0.33654 facility: Joint Clinical Research Facility - Swansea city: Swansea zip: SA2 8PP country: United Kingdom lat: 51.62079 lon: -3.94323 hasResults: False