hackint0sh/New-Dataset huggingface dataset:
Single-blinded: Researchers are blind as regards group belonging of participants. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: schema therapy measure: Changes in emotion regulation capabilities measure: Improvement of BPD specific symptomatology measure: Change of personality traits measure: Changes of the intensity of early maladaptive schemas. measure: Changes of the intensity of schema modes. sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Jena status: RECRUITING city: Jena zip: 07743 country: Germany name: Stefan Smesny, PhD role: CONTACT phone: +4936419390451 email: stefan.smesny@med.uni-jena.de lat: 50.92878 lon: 11.5899 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol: Study Protocol: Study design date: 2018-06-04 uploadDate: 2024-04-12T04:07 filename: Prot_000.pdf size: 653719 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol: Study Protocol: Study design date: 2018-06-04 uploadDate: 2024-04-12T04:14 filename: Prot_001.pdf size: 454285 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol: Information on reliability criteria of assessment tools date: 2018-06-04 uploadDate: 2024-04-12T04:22 filename: Prot_002.pdf size: 605787 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol: Core aspects of therapy conditions date: 2018-06-04 uploadDate: 2024-04-12T04:23 filename: Prot_003.pdf size: 440449 typeAbbrev: SAP hasProtocol: False hasSap: True hasIcf: False label: Statistical Analysis Plan date: 2018-06-04 uploadDate: 2024-04-12T04:10 filename: SAP_004.pdf size: 692600 hasResults: False
nctId: NCT06367894 id: STONECARE briefTitle: Treatment Optimization and Nephrolithiasis Recurrence Prevention With Interdisciplinary Care overallStatus: RECRUITING date: 2023-12-12 date: 2024-12-31 date: 2024-12-31 date: 2024-04-16 date: 2024-04-16 name: Agnieszka Pozdzik class: OTHER briefSummary: Nearly 10% of the Belgian population suffer from kidney stone disease. Recent reviews reported that kidney stones represent an underestimated risk factor for further kidney function deterioration. Preventive measures are recommended in lithiases patients to prevent the formation of new stones. The individual effects of different medicated prosthetic interventions have been documented in clinical trials. However, there is little data on the effectiveness of combining these different preventive measures in routine clinical practice (real-world context).
Patients with kidney stone disease require a complete metabolic assessment. The three main factors contributing to the stone's formation are the patient's metabolism, diet and lifestyle. Metabolic work-up is recommended by the American Urology Association to identify and correct the factors responsible for urinary stone formation such as hypercalciuria, hyperoxaluria, hyperuricuria, hypocitraturia or abnormalities of urinary pH. The metabolic work-up includes at minimum the 24h urine test, a blood test and spot urine test. Dietary habits and lifestyle are assessed by means of a questionnaire.
The aim of this study is to evaluate, in the context of a retrospective single-center cohort study, the effect of preventive personalized and interdisciplinary care on the evolution of all urinary lithogenic risk factors and the recurrence of kidney stones (rate of renal colics, emergency room admissions, and urological interventions). conditions: Kidney Stone studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 164 type: ESTIMATED measure: Number of acute renal colics measure: Number of emergency admissions measure: Number of surgeries measure: Number of hospitalizations measure: Identified genetics abnormalities measure: Wisconsin questionnaire measure: Kidney function outcome sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU Brugmann status: RECRUITING city: Brussels zip: 1020 country: Belgium name: Agnieszka POZDZIK role: CONTACT phone: 024772641 email: Agnieszka.POZDZIK@chu-brugmann.be name: Sirika Chhem role: PRINCIPAL_INVESTIGATOR lat: 50.85045 lon: 4.34878 hasResults: False
nctId: NCT06367881 id: MD 185/ 2022 briefTitle: Assessment Of Dose-Dependent Immunomodulatory Effect Of Alveofact With or Without Steroisd In Neonatal RDS overallStatus: RECRUITING date: 2022-08-18 date: 2024-07 date: 2024-10 date: 2024-04-16 date: 2024-04-16 name: Ain Shams University class: OTHER briefSummary: An Exploratory Randomized double-arm controlled trial to evaluate the immunomodulatory effect of low versus high dose of Alveofact with or without Budesonide. conditions: Neonatal Respiratory Distress Syndrome conditions: Inflammatory Response conditions: Premature Lungs conditions: Neutrophil Extracellular Trap Formation conditions: Preterm Birth studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Alveofact name: Budesonide measure: Assessment of Neutrophil Extracellular Trap (NET) measure: comparison of Alveolar with whole blood NET formation measure: Clinical out come measure: Assessment of Reactive Oxygen Species (ROS) measure: oxygen needs measure: Hospital stay sex: ALL minimumAge: 1 Day maximumAge: 2 Days stdAges: CHILD facility: Egypt Neonatal Intensive Care Units (NICUs), Ain Shams University Cairo, Abbasia, Egypt, 11517 status: RECRUITING city: Cairo country: Egypt name: Ain Shams University role: CONTACT lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06367868 id: E-83045809-604.01.02-179951 briefTitle: Optic Nerve Sheath Diameter: A Non-Invasive Indicator of Intracranial Pressure in the Intensive Care Unit Monitoring overallStatus: COMPLETED date: 2021-09-09 date: 2022-06-01 date: 2022-12-01 date: 2024-04-16 date: 2024-04-16 name: Istanbul University - Cerrahpasa (IUC) class: OTHER briefSummary: Determination of high intracranial pressure (ICP) is necessary for the treatment of patients with raised ICP to improve long-term neurological outcomes. Ultrasonographic optic nerve sheath diameter (ONSD) measurement is a noninvasive, easily performed and cost effective technique for detecting high ICP. conditions: ICP (Intracranial Pressure) Increase conditions: Optic Nerve Sheath Diameter conditions: Intracranial Hypertension studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 44 type: ACTUAL name: After 5 ml CSF Drainage measure: Intracranial Pressure-1 (ICP-1) measure: Optic Nerve Sheath Diameter-1 (ONSD-1) measure: Intracranial Pressure-2 (ICP-2) measure: Optic Nerve Sheath Diameter-2 (ONSD-2) sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istanbul University-Cerrahpasa city: Istanbul state: Fatıh zip: 34098 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06367855 id: KSKC20222025 briefTitle: Efficacy and Safety of Preemptive Intravenous Dexamethasone in MIS-TLIF : Double Blinded, Randomized Control Trial acronym: MIS-TLIF overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-04-30 date: 2025-05-31 date: 2024-04-16 date: 2024-04-16 name: Potsawat Surabotsopon class: OTHER briefSummary: Researchers are considering Dexamethasone as preemptive medication before minimally invasive spine fusion surgery to minimize postoperative back pain with minimal side effects, aiming to enhance the effectiveness of surgery and improve patient outcomes. conditions: Spinal Stenosis Lumbar conditions: Disc Degeneration conditions: Disc Disease conditions: Fusion of Spine conditions: Surgery studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Dexamethasone name: Normal saline measure: effectiveness of dexamethasone measure: Morphine consumption measure: Complication measure: Fusion rate measure: Length of hospital stay sex: ALL minimumAge: 50 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06367842 id: MED-02-2023 briefTitle: Orthopaedic Specimen Pathology and Early Diagnosis of ATTR Cardiopathy (ATTR-ORTHO) acronym: ATTR-ORTHO overallStatus: RECRUITING date: 2024-02-27 date: 2025-04 date: 2025-09 date: 2024-04-16 date: 2024-04-16 name: Institut Mutualiste Montsouris class: OTHER briefSummary: The goal of this observational study is to learn about the frequency of ATTR amyloid, cardiac involvement and associated features, in 150 patients aged 50 or more years, and operated for an idiopathic carpal tunnel syndrome, lumbar spine stenosis or total hip or knee arthroplasty for primary osteoarthritis. The main questions to be answered are:
Researchers will assess the frequency of ATTR deposits at each operated site, the frequency or ATTR cardiopathy in ATTR + patients, and will compare demographic, clinical, biochemical, and imaging features in patients with and without ATTR deposits, to guide the indications of pathological examination during these frequent orthopedic surgeries conditions: ATTR Amyloidosis conditions: Cardiopathy conditions: Carpal Tunnel Syndrome conditions: Lumbar Spine Stenosis conditions: Hip Prosthesis conditions: Knee Prosthesis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 150 type: ESTIMATED measure: frequency of ATTR amyloidosis measure: presence of ATTR cardiopathy measure: proportion of wild type and hereditary ATTR measure: Description of preoperative predictors of ATTR measure: Description of preoperative predictors of ATTR measure: preoperative predictors of ATTR sex: ALL minimumAge: 50 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mutualist Montsouris Institute status: RECRUITING city: Paris zip: 75014 country: France name: Thomas M Bardin, Pr role: CONTACT phone: +33 156616263 email: thomas.bardin@imm.fr lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06367829 id: WO.24.025 briefTitle: Lubinus SPII Hip Stem Target Trial Emulation (LARGE) acronym: LARGE overallStatus: ENROLLING_BY_INVITATION date: 2024-01-08 date: 2024-07-14 date: 2025-01-08 date: 2024-04-16 date: 2024-04-16 name: JointResearch class: OTHER name: OLVG name: Uppsala University name: Göteborg University name: Leiden University Medical Center briefSummary: The research questions this study aims to answer are as follows:
To answer these questions, this study has been allowed use of registered data from the LROI (dutch arthroplasty registry) and the SAR (swedish arthroplasty registry). After exclusion of patients who did not meet inclusion criteria between 2007-2020, approximately 110000 patients remain eligible for analysis. conditions: Treatment Outcome studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: OTHER count: 110000 type: ESTIMATED name: Lubinus SPII hip stem 130mm name: Lubinus SPII hip stem 150mm measure: Mortality rate measure: Revision rate measure: NRS pain score measure: Oxford hip score measure: EQ - 5D measure: HOOS - PS measure: Revision rate measure: Mortality rate sex: ALL minimumAge: 5 Years maximumAge: 105 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: OLVG city: Amsterdam state: Noord Holland zip: 1090 HM country: Netherlands lat: 52.37403 lon: 4.88969 hasResults: False
nctId: NCT06367816 id: 13509 briefTitle: Brain Recovery With Automated VEntilation acronym: BRAVE overallStatus: RECRUITING date: 2024-04-11 date: 2024-12-31 date: 2024-12-31 date: 2024-04-16 date: 2024-04-16 name: University of Genova class: OTHER briefSummary: Thus far, the closed-loop ventilation mode INTELLiVENT-ASV has been extensively tested in various groups of critically ill patients, and has been shown to be effective and safe in various groups of ventilated patients, including those at risk of acute respiratory distress syndrome (ARDS), patients with ARDS, and patients with chronic obstructive pulmonary disease (COPD). Some of these studies included acute brain injury (ABI) patients, but the effectiveness, efficacy and safety of INTELLiVENT-ASV has never been thoroughly tested in these patients. The current study will investigate the effectiveness in providing both brain- and lung protective ventilation, the safety and the efficacy of a closed-loop ventilation mode (INTELLiVENT-ASV) in acute brain injury patients, using breath-by-breath data. conditions: Brain Injuries, Acute conditions: Respiration, Artificial conditions: Automation studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED name: INTELLiVENT name: Conventional ventilation measure: Proportion of breaths in predefined zones of ventilation measure: Proportion of time in predefined zones of ventilation measure: Intracerebral changes assessed by multimodal neuromonitoring available measure: Changes on Electrical Impedence Tomography when available measure: Effectiveness in primary ABI patients vs non primary ABI patients measure: Episodes and time of high maximum airway pressure measure: Episodes and time of high respiratory rate measure: Incidence of severe hypoxemia measure: Incidence of severe hypercapnia measure: Discontinuation of ventilatory mode (yes or no) measure: Percentage of breaths in the predefined 'critical' ventilation zone measure: Incidence of pneumothorax measure: Efficacy on glascow coma scale measure: Duration of ventilation in survivors measure: Ventilator free days measure: Intensive care unit length of stay measure: Hospital length of stay measure: 28-day mortality measure: 90-day mortality measure: Number of alarms measure: Number of manual adjustments sex: ALL minimumAge: 18 Years maximumAge: 105 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UO Clinica Anestesiologica e Terapia Intensiva, IRCCS Ospedale Policlinico San Martino status: RECRUITING city: Genova state: GE zip: 16132 country: Italy name: Denise Battaglini, MD, PhD role: CONTACT phone: +39-0105554970 email: battaglini.denise@gmail.com name: Lorenzo Ball, MD, PhD role: CONTACT phone: +39-0105554970 email: lorenzo.ball@unige.it lat: 44.40478 lon: 8.94438 hasResults: False
nctId: NCT06367803 id: DVS010 briefTitle: Cost Analysis of Vascular Surgical Techniques overallStatus: COMPLETED date: 2023-06-01 date: 2023-12-01 date: 2024-03-01 date: 2024-04-16 date: 2024-04-16 name: University Hospital of Limerick class: OTHER briefSummary: Whilst mortality rates and surgical limitations are widely known and understood for each intervention performed, the cost implications, in UHL, are not known. Therefore, it is deemed a matter of interest to understand these costs and weigh them against the mortality rates for each intervention if available. conditions: Critical Limb Ischemia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 200 type: ACTUAL measure: A comparative assessment of the cost implications of the surgical modalities used in the treatment of CLTI i.e., revascularisation and amputation. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Limerick city: Limerick state: Munster country: Ireland lat: 52.66472 lon: -8.62306 hasResults: False
nctId: NCT06367790 id: Bask-Pliomet briefTitle: Plyometry and Tapping in the Functional Improvement of Non-professional Basketball Players overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-06-10 date: 2024-07-01 date: 2024-04-16 date: 2024-04-16 name: Universidad Católica San Antonio de Murcia class: OTHER briefSummary: Introduction. In basketball, the lower extremities have the highest prevalence of injury, regardless of gender and professional category.
Methods. Randomised clinical study. 20 players will be randomised to an experimental group (plyometric exercises and dry needling of the gastrocnemius muscles) and a control group (plyometric exercises). The intervention will include 8 sessions over 4 weeks. The study variables will be: range of motion in dorsal flexion in loading (Leg Motion®) and unloading (goniometer) and vertical jump (MyJump2®).
Expected results. An intervention of plyometric exercises and dry needling produces significant differences in range of motion and vertical jump in basketball players, compared to the isolated administration of plyometric exercises. conditions: Basketball Players studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: Experimental group name: Control group measure: Change from baseline range of motion in loaded dorsal flexion after treatment and at 4 weeks measure: Change from baseline range of motion in unloaded dorsal flexion after treatment and at 4 weeks measure: Change from baseline vertical jump after treatment and at 4 weeks sex: MALE minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Rubén Cuesta-Barriuso city: Oviedo state: Asturias zip: 33006 country: Spain name: Rubén Cuesta-Barriuso, PhD role: CONTACT phone: 607547274 email: cuestaruben@uniovi.es lat: 43.36029 lon: -5.84476 hasResults: False
nctId: NCT06367777 id: 2024/14MAR/132 briefTitle: Cervical/Thoracic Neuromodulation and Nociceptive Processing acronym: MICROVOLT2 overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-10 date: 2024-10 date: 2024-04-16 date: 2024-04-16 name: Université Catholique de Louvain class: OTHER briefSummary: Several studies have demonstrated that direct currents delivered through the skin at the level of the low-thoracic spinal cord can influence spinal cord function. In human volunteers, anodal low-thoracic transcutaneous spinal direct current stimulation (tsDCS) alters spinal processing of nociceptive inputs. Whether cervical tsDCS is able to do the same is less well known. In this double-blinded, sham-controlled and cross-over trial, the investigators will compare the effects on the nociceptive processing of healthy volunteers of cervical and low-thoracic tsDCS. conditions: Nociceptive Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: cervical a-tsDCS name: thoracic a-tsDCS name: sham tsDCS measure: Change in contact-heat evoked potentials amplitude measure: Change in intensity of perception to contact-heat nociceptive stimuli measure: Change in skin temperature measure: Change in cutaneous blood flow sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT hasResults: False
nctId: NCT06367764 id: BPS-2022C3-30535 briefTitle: A Comparative Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations acronym: LIFESCAPE overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2028-06 date: 2028-06 date: 2024-04-16 date: 2024-04-23 name: University of California, San Francisco class: OTHER name: Patient-Centered Outcomes Research Institute name: Stanford University briefSummary: The goal of this clinical trial is see if Cognitive Processing Therapy and STAIR Narrative Therapy work to treat posttraumatic stress disorder (PTSD) among lesbian, gay, bisexual, transgender, queer/questioning, intersex, asexual/aromantic, and all other sexual or gender minority (LGBTQIA+) adults. The main questions it aims to answer are:
Study participants will receive one of these two PTSD treatments. Participants will complete assessments before and after receiving treatment. conditions: PTSD studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 400 type: ESTIMATED name: Cognitive Processing Therapy name: STAIR Narrative Therapy measure: Change in Posttraumatic Stress Disorder (PTSD) Symptoms Measured by PTSD Checklist for DSM-5 (PCL-5) measure: Change in Depression Measured by Patient Health Questionnaire (PHQ-9) measure: Change in Quality of Life Measured by WHOQOL-BREF: Social Relationships and Environment Scales measure: Patient Satisfaction Measured By Satisfaction with Therapy and Therapist Scale-Revised (STTS-R) measure: Assessing Treatment Dropout Measured by Completion of Less than 8 Sessions measure: Minority Stress Measured by Cultural Assessment of Risk for Suicide (CARS) Minority Stress Subscale - Moderator measure: Substance Use Measured Alcohol and Substance, Smoking, and Substance Involvement Screening Test (ASSIST) - Moderator sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UCSF Alliance Health Project city: San Francisco state: California zip: 94103 country: United States name: Annesa Flentje, PhD role: CONTACT lat: 37.77493 lon: -122.41942 hasResults: False
nctId: NCT06367751 id: 2024-00358; th23Kasenda briefTitle: Implementation of Liquid Biopsies During Routine Clinical Care in Patients With Advanced Malignancies (LIQPLAT) acronym: LIQPLAT overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-10 date: 2026-10 date: 2024-04-16 date: 2024-04-19 name: University Hospital, Basel, Switzerland class: OTHER name: Research Center for Clinical Neuroimmunology and Neuroscience Basel briefSummary: The goal of this study is to assess the implementation and feasibility of ctDNA measurements from blood samples obtained during routine clinical care of cancer patients in the University Hospital Basel.
Blood samples will be drawn from the patients as part of routine care and ctDNA measurements will be performed on these samples. conditions: Advanced Solid Tumor studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This is a trial using routinely collected health care data from an ongoing registry (AO_2023-00091) in cancer patients with advanced solid malignancies receiving first line systemic anti-cancer treatment for advanced disease. All patients will receive routine diagnostics, treatment and follow-up. All patients with a new cancer diagnosis will be assessed for eligibility based on the routinely collected information available in the registry. We will then randomly decide which eligible patients are invited to participate in the trial. If patients accept the invitation and intend to get a measurement of ctDNA, they have to provide written informed consent. The study comprises an external comparator arm with 75 (anticipated) cancer patients, and an active comparator arm with 150 (anticipated) cancer patients. primaryPurpose: OTHER masking: NONE count: 150 type: ESTIMATED name: ctDNA measurement measure: Number and proportion of patients in whom ctDNA was detectable before starting medical anticancer treatment measure: Patients in whom actionable alterations were identified in ctDNA analysis measure: Turn-around time of ctDNA analysis measure: ctDNA kinetics measure: Number of ctDNA testing results that were successfully made available to the molecular tumor board measure: Number of patients being positive for ctDNA and suspicious Clonal Hematopoiesis of Indeterminate Potential measure: Quality of life and physical function measure: Overall survival measure: Survival rate 6 months measure: Survival rate 12 months measure: Time to next treatment line measure: Unplanned hospital admissions and emergency room visits measure: Progression free survival measure: Number of ctDNA analyses with a valid result measure: Patients being referred and recruited to a different interventional clinical trial measure: Tissue biopsies per patient measure: Imaging per patient measure: Blood products per patient measure: Cumulative doses of cancer drug treatments administered sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False