nctId: NCT06295679 id: 20180442 briefTitle: A Study Assessing Repatha® in Combination With Standard of Care (SOC) Compared With SOC on Major Cardiovascular Events in Chinese Participants With Atherosclerotic Cardiovascular Disease overallStatus: RECRUITING date: 2022-12-19 date: 2028-12-19 date: 2028-12-19 date: 2024-03-06 date: 2024-04-25 name: Amgen class: INDUSTRY briefSummary: The primary objective of the study is to evaluate real-world effectiveness of treatment with Repatha® in combination with SOC, compared with SOC alone, on the risk for cardiovascular (CV) death, myocardial infarction (MI), stroke, hospitalization for unstable angina, or coronary revascularization, whichever occurs first, in participants with established atherosclerotic CV disease (ASCVD) treated with SOC, according to local clinical practice. conditions: Major Cardiovascular Event conditions: Established Atherosclerotic Cardiovascular Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 7000 type: ESTIMATED measure: Time to CV Death, MI, Hospitalization for Unstable Angina, Stroke, or Coronary Revascularization, Whichever Occurs First measure: Time to CV Death, MI, or Stroke, Whichever Occurs First measure: Change in Low-density Lipoprotein Cholesterol (LDL-C) From Baseline measure: Percent Change in LDL-C From Baseline measure: Number of Participants Who Experienced Adverse Events measure: Number of Participants Who Experienced Adverse Drug Reactions sex: ALL minimumAge: 18 Years maximumAge: 150 Years stdAges: ADULT stdAges: OLDER_ADULT facility: China Japan Friendship Hospital status: RECRUITING city: Beijing state: Beijing zip: 100029 country: China lat: 39.9075 lon: 116.39723 facility: Peking University First Hospital status: RECRUITING city: Beijing state: Beijing zip: 100034 country: China lat: 39.9075 lon: 116.39723 facility: Beijing Haidian Hospital status: RECRUITING city: Beijing state: Beijing zip: 100086 country: China lat: 39.9075 lon: 116.39723 facility: Peking University Third Hospital status: RECRUITING city: Beijing state: Beijing zip: 100191 country: China lat: 39.9075 lon: 116.39723 facility: Beijing Hospital status: RECRUITING city: Beijing state: Beijing zip: 100730 country: China lat: 39.9075 lon: 116.39723 facility: Chongqing Emergency Medical Center status: RECRUITING city: Chongqing state: Chongqing zip: 400014 country: China lat: 29.56278 lon: 106.55278 facility: Chongqing General Hospital status: RECRUITING city: Chongqing state: Chongqing zip: 401121 country: China lat: 29.56278 lon: 106.55278 facility: Dongguan Songshan Lake Central Hospital status: RECRUITING city: Dong Guan state: Guangdong zip: 523127 country: China facility: The First Peoples Hospital of Foshan status: RECRUITING city: Foshan state: Guangdong zip: 528000 country: China lat: 23.02677 lon: 113.13148 facility: The First Affiliated Hospital of Shantou University Medical College status: RECRUITING city: Guangzhou state: Guangdong zip: 510280 country: China lat: 23.11667 lon: 113.25 facility: Zhujiang Hospital of Southern Medical University status: RECRUITING city: Guangzhou state: Guangdong zip: 510280 country: China lat: 23.11667 lon: 113.25 facility: Nanfang Hospital, Southern Medical University status: RECRUITING city: Guangzhou state: Guangdong zip: 510515 country: China lat: 23.11667 lon: 113.25 facility: The First Affiliated Hospital of Jinan University status: RECRUITING city: Guangzhou state: Guangdong zip: 510630 country: China lat: 23.11667 lon: 113.25 facility: The Third Affiliated Hospital of Sun Yat-sen University status: RECRUITING city: Guangzhou state: Guangdong zip: 510630 country: China lat: 23.11667 lon: 113.25 facility: The Third Peoples Hospital of Huizhou City status: RECRUITING city: Huizhou state: Guangdong zip: 516002 country: China lat: 23.11147 lon: 114.41523 facility: Zhuhai Peoples Hospital status: RECRUITING city: Zhuhai state: Guangdong zip: 519050 country: China lat: 22.27694 lon: 113.56778 facility: The First Peoples Hospital of Yulin status: RECRUITING city: Yulin state: Guangxi zip: 537006 country: China lat: 22.63333 lon: 110.15 facility: The Second Affiliated Hospital of Guilin Medical University status: RECRUITING city: Yulin state: Guangxi zip: 541199 country: China lat: 22.63333 lon: 110.15 facility: The Affiliated Hospital of Guizhou Medical University status: RECRUITING city: Guiyang state: Guizhou zip: 550001 country: China lat: 26.58333 lon: 106.71667 facility: Cangzhou Central Hospital status: RECRUITING city: Cangzhou state: Hebei zip: 061001 country: China lat: 38.31667 lon: 116.86667 facility: Tangshan Gongren Hosipital status: RECRUITING city: Tangshan state: Hebei zip: 063000 country: China lat: 39.63333 lon: 118.18333 facility: Heilongjiang Provincial Hospital status: RECRUITING city: Haerbin state: Heilongjiang zip: 150036 country: China lat: 31.8696 lon: 101.742 facility: Huaihe Hospital of Henan University status: RECRUITING city: Kaifeng state: Henan zip: 475000 country: China lat: 34.7986 lon: 114.30742 facility: Nanyang Central Hospital status: RECRUITING city: Nanyang state: Henan zip: 473000 country: China lat: 32.99472 lon: 112.53278 facility: The Seventh Peoples Hospital of Zhengzhou status: RECRUITING city: Zhengzhou state: Henan zip: 450016 country: China lat: 34.75778 lon: 113.64861 facility: The First Affiliated hospital of Zhengzhou University status: RECRUITING city: Zhengzhou state: Henan zip: 450052 country: China lat: 34.75778 lon: 113.64861 facility: The Central Hospital of Wuhan status: RECRUITING city: Wuhan state: Hubei zip: 430014 country: China lat: 30.58333 lon: 114.26667 facility: Union Hospital Tongji Medical College Huazhong University of science and Technology status: RECRUITING city: Wuhan state: Hubei zip: 430022 country: China lat: 30.58333 lon: 114.26667 facility: Wuhan No 1 Hospital status: RECRUITING city: Wuhan state: Hubei zip: 430022 country: China lat: 30.58333 lon: 114.26667 facility: Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology status: RECRUITING city: Wuhan state: Hubei zip: 430030 country: China lat: 30.58333 lon: 114.26667 facility: Wuhan Third Hospital-Tongren Hospital Of Wuhan University status: RECRUITING city: Wuhan state: Hubei zip: 430060 country: China lat: 30.58333 lon: 114.26667 facility: Hunan Provincial Peoples Hospital status: RECRUITING city: Changsha state: Hunan zip: 410005 country: China lat: 28.19874 lon: 112.97087 facility: Changshu No1 Peoples Hospital status: RECRUITING city: Changshu state: Jiangsu zip: 215500 country: China lat: 29.44395 lon: 118.88005 facility: Changshu NO2 Peoples Hospital status: RECRUITING city: Changshu state: Jiangsu zip: 215523 country: China lat: 29.44395 lon: 118.88005 facility: Nantong First Peoples Hospital status: RECRUITING city: Nantong state: Jiangsu zip: 226000 country: China lat: 32.03028 lon: 120.87472 facility: The first peoples hospital of Kunshan status: RECRUITING city: Suzhou state: Jiangsu zip: 215300 country: China lat: 31.30408 lon: 120.59538 facility: Wuxi Peoples Hospital status: RECRUITING city: Wuxi state: Jiangsu zip: 214023 country: China lat: 31.56887 lon: 120.28857 facility: The Affiliated Hospital of Xuzhou Medical University status: RECRUITING city: Xuzhou state: Jiangsu zip: 221006 country: China lat: 34.18045 lon: 117.15707 facility: Jiangxi Provincial People Hospital status: RECRUITING city: Nanchang state: Jiangxi zip: 330006 country: China lat: 28.68396 lon: 115.85306 facility: The first affiliated Hospital of Nanchang University status: RECRUITING city: Nanchang state: Jiangxi zip: 330006 country: China lat: 28.68396 lon: 115.85306 facility: The First Hospital of Nanchang status: RECRUITING city: Nanchang state: Jiangxi zip: 330008 country: China lat: 28.68396 lon: 115.85306 facility: The Second Hospital of Jilin University status: RECRUITING city: Changchun state: Jilin zip: 13041 country: China lat: 43.88 lon: 125.32278 facility: Dalian Municipal Central Hospital Affiliated Of Dalian Medical University status: RECRUITING city: Dalian state: Liaoning zip: 116000 country: China lat: 38.91222 lon: 121.60222 facility: The First Affiliated Hospital of Dalian Medical University status: RECRUITING city: Dalian state: Liaoning zip: 116000 country: China lat: 38.91222 lon: 121.60222 facility: The Second Hospital of Dalian Medical University status: RECRUITING city: Dalian state: Liaoning zip: 116027 country: China lat: 38.91222 lon: 121.60222 facility: The First Affiliated Hospital of Jinzhou Medical University status: RECRUITING city: Jinzhou state: Liaoning zip: 121000 country: China lat: 41.10778 lon: 121.14167 facility: General Hospital of Northern Theater Command status: RECRUITING city: Shenyang state: Liaoning zip: 110016 country: China lat: 41.79222 lon: 123.43278 facility: The Forth Affiliated Hospital of China Medical University status: RECRUITING city: Shenyang state: Liaoning zip: 110032 country: China lat: 41.79222 lon: 123.43278 facility: Tangdu Hospital,Air Force Military Medical University status: RECRUITING city: Xi'an state: Shaanxi zip: 710038 country: China lat: 34.25833 lon: 108.92861 facility: Shaanxi Provincial Peoples Hospital status: RECRUITING city: Xi'an state: Shaanxi zip: 710068 country: China lat: 34.25833 lon: 108.92861 facility: Qilu Hospital of Shandong University status: RECRUITING city: Jinan state: Shandong zip: 250012 country: China lat: 36.66833 lon: 116.99722 facility: Jinan Central Hospital status: RECRUITING city: Jinan state: Shandong zip: 250013 country: China lat: 36.66833 lon: 116.99722 facility: Shandong Qianfoshan Hospital status: RECRUITING city: Jinan state: Shandong zip: 250014 country: China lat: 36.66833 lon: 116.99722 facility: Shandong Provincial Hospital status: RECRUITING city: Jinan state: Shandong zip: 250021 country: China lat: 36.66833 lon: 116.99722 facility: Affiliated hospital of Jining Medical University status: RECRUITING city: Jining state: Shandong zip: 272009 country: China lat: 35.405 lon: 116.58139 facility: Zibo central Hospital status: RECRUITING city: Zibo state: Shandong zip: 255030 country: China lat: 36.79056 lon: 118.06333 facility: Xinhua Hospital Affiliated To Shanghai Jiaotong University School of Medicine status: RECRUITING city: Shanghai state: Shanghai zip: 200092 country: China lat: 31.22222 lon: 121.45806 facility: The Second Hospital of Shanxi Medical University status: RECRUITING city: Taiyuan state: Shanxi zip: 030001 country: China lat: 37.86944 lon: 112.56028 facility: The First Affiliated Hospital of Xi An Jiaotong University status: RECRUITING city: XI An state: Shanxi zip: 710061 country: China facility: Chengdu First Peoples Hospital status: RECRUITING city: Chengdu state: Sichuan zip: 610041 country: China lat: 30.66667 lon: 104.06667 facility: Chengdu Third Peoples Hospital status: RECRUITING city: Chengdu state: Sichuan zip: 61031 country: China lat: 30.66667 lon: 104.06667 facility: Tianjin Peoples Hospital status: RECRUITING city: Tianjin state: Tianjin zip: 300120 country: China lat: 39.14222 lon: 117.17667 facility: Tianjin Chest Hospital status: RECRUITING city: Tianjin state: Tianjin zip: 300222 country: China lat: 39.14222 lon: 117.17667 facility: The First Affiliated Hospital of Xinjiang Medical University status: RECRUITING city: Urumqi state: Xinjiang zip: 830054 country: China lat: 43.80096 lon: 87.60046 facility: Yanan Hospital of Kunming City status: RECRUITING city: Kunming state: Yunnan zip: 473009 country: China lat: 25.03889 lon: 102.71833 facility: First Affiliated Hospital of Kunming Medical University status: RECRUITING city: Kunming state: Yunnan zip: 650032 country: China lat: 25.03889 lon: 102.71833 facility: Yunnan First Peoples Hospital status: RECRUITING city: Kunming state: Yunnan zip: 650032 country: China lat: 25.03889 lon: 102.71833 facility: Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine status: RECRUITING city: Hangzhou state: Zhejiang zip: 310016 country: China lat: 30.29365 lon: 120.16142 facility: the First Peoples Hospital of Xiaoshan District Hangzhou status: RECRUITING city: Hangzhou state: Zhejiang zip: 311201 country: China lat: 30.29365 lon: 120.16142 facility: Huzhou Central Hospital status: RECRUITING city: Huzhou state: Zhejiang zip: 310005 country: China lat: 30.8703 lon: 120.0933 facility: The First Peoples Hospital of Huzhou status: RECRUITING city: Huzhou state: Zhejiang zip: 313000 country: China lat: 30.8703 lon: 120.0933 facility: Jiaxing Second Hospital status: RECRUITING city: Jiaxing state: Zhejiang zip: 314000 country: China lat: 30.7522 lon: 120.75 facility: The first affiliated hospital of Ningbo university status: RECRUITING city: Ningbo state: Zhejiang zip: 315010 country: China lat: 29.87819 lon: 121.54945 facility: Ningbo medical center lihuili hospital status: RECRUITING city: Ningbo state: Zhejiang zip: 315046 country: China lat: 29.87819 lon: 121.54945 facility: Shaoxing Second Hospital status: RECRUITING city: Shaoxing state: Zhejiang zip: 312000 country: China lat: 30.00237 lon: 120.57864 facility: Beijing Anzhen Hospital, Capital Medical University status: RECRUITING city: Beijing zip: 100029 country: China lat: 39.9075 lon: 116.39723 facility: Tongji Hospital of Tongji University status: RECRUITING city: Shanghai zip: 200065 country: China lat: 31.22222 lon: 121.45806 hasResults: False