In this context, we propose a randomized controlled non-inferiority study to demonstrate that in liver transplant recipients, an immunosuppressive strategy based on single daily doses of LCP-tacrolimus (ENVARSUS XR®) and mycophenolate mofetil (CELLCEPT®) started at M6 post-transplantation is not inferior to XR-tacrolimus (ADVAGRAF®) and MMF administered BID, in terms of incidence of treatment failure (see below) at the end of the first year after transplantation, and to obtain adherence, quality of life and safety data. In order to compare solely MMF QD to MMF BID, patients on ENVARSUS XR® and MMF QD will be compared to a third group of patients receiving ENVARSUS XR® and MMF BID. A direct comparison of efficacy and safety, quality of life, adherence and exposure indices will be performed between ENVARSUS XR® and ADVAGRAF®. conditions: Liver Transplantation conditions: Immunosuppression studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 162 type: ESTIMATED name: XR-tacrolimus QD + MMF BID name: LCP-tacrolimus QD + MMF BID name: LCP-tacrolimus QD + MMF QD measure: Treatment failure measure: Adherence to treatment measure: measuring of quality of life measure: Adherence to treatment measure: measuring of quality of life measure: Appearance Adverse events measure: Appearance Adverse events measure: Comparison tacrolimus daily exposure measure: Comparison of MPA daily exposure measure: Comparison of Tacrolimus dose measure: Comparison of Tacrolimus AUC 0-24h measure: Comparison of MPA AUC 0-24h sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beaujon hospital - APHP city: Clichy zip: 92110 country: France lat: 48.90018 lon: 2.30952 facility: Lille university hospital city: Lille zip: 59000 country: France name: Sébastien DHARANCY, MD role: CONTACT email: sebastien.dharancy@chru-lille.fr name: Sébastien DHARANCY, MD role: PRINCIPAL_INVESTIGATOR lat: 50.63297 lon: 3.05858 facility: Limoges university hospital city: Limoges zip: 87042 country: France name: Marilyne DEBETTE-GRATIEN, MD role: CONTACT email: MARILYNE.GRATIEN@chu-limoges.fr name: Marilyne DEBETTE-GRATIEN, MD role: PRINCIPAL_INVESTIGATOR lat: 45.83153 lon: 1.25781 facility: Lyon university hospital city: Lyon zip: 69000 country: France name: Teresa ANTONINI, MD role: CONTACT email: teresa.antonini@chu-lyon.fr name: Teresa ANTONINI, MD role: PRINCIPAL_INVESTIGATOR lat: 45.74848 lon: 4.84669 facility: Montpellier university hospital city: Montpellier zip: 34000 country: France name: Georges-Philippe PAGEAUX, MD role: CONTACT email: gp-pageaux@chu-montpellier.fr name: Georges-Philippe PAGEAUX, MD role: PRINCIPAL_INVESTIGATOR lat: 43.61092 lon: 3.87723 facility: Nice university hospital city: Nice zip: 06202 country: France name: Rodolphe ANTY, MD role: CONTACT email: anty.r@chu-nice.fr name: Rodolphe ANTY, MD role: PRINCIPAL_INVESTIGATOR lat: 43.70313 lon: 7.26608 facility: Pitie Salpetriere hospital - APHP city: Paris zip: 75013 country: France lat: 48.85341 lon: 2.3488 facility: Bordeaux university hospital city: Pessac zip: 33604 country: France name: Jean-Baptiste HIRIART, MD role: CONTACT email: jean-baptiste.hiriart@chu-bordeaux.fr name: Jean-Baptiste HIRIART, MD role: PRINCIPAL_INVESTIGATOR lat: 44.81011 lon: -0.64129 facility: Poitiers university hospital city: Poitiers zip: 86000 country: France name: Christine SILVAIN, MD role: CONTACT email: c.silvain@chu-poitiers.fr name: Christine SILVAIN, MD role: PRINCIPAL_INVESTIGATOR lat: 46.58333 lon: 0.33333 facility: Rennes university hospital city: Rennes zip: 35033 country: France name: Pauline HOUSSEL-DEBRY, MD role: CONTACT email: pauline.houssel-debry@chu-rennes.fr name: Pauline HOUSSEL-DEBRY, MD role: PRINCIPAL_INVESTIGATOR lat: 48.11198 lon: -1.67429 facility: Strasbourg university hospital city: Strasbourg zip: 67000 country: France name: Camille BESCH, MD role: CONTACT email: camille.besch@chru-strasbourg.fr name: Camille BESCH, MD role: PRINCIPAL_INVESTIGATOR lat: 48.58392 lon: 7.74553 facility: Tours university Hospital city: Tours zip: 37000 country: France lat: 47.38333 lon: 0.68333 facility: Paul Brousse Hospital - APHP city: Villejuif zip: 94800 country: France lat: 48.7939 lon: 2.35992 hasResults: False