hackint0sh/New-Dataset huggingface dataset:
Conclusion: When the literature was scanned, it was seen that the number of studies examining the effect of oral whey on metabolic and endocrine values in orthopedic patients was very limited and academic studies were needed. In this context, examining the effect of whey intake given before THA on the patient's blood glucose, CRP, albumin, cortisol, insulin resistance and healing quality is an original research that will contribute to the field. conditions: Crp conditions: Insulin Resistance conditions: Cortisol; Hypersecretion conditions: Albus; Lichen conditions: Quality of Life studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: randomize control trials primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: randomize clinical study whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: whey protein intake before surgery name: Water before surgery measure: Rate of C Reactive Protein measure: Rate of insulin resistance measure: Rate of albumen measure: Rate of cortisol measure: Healing Quality sex: ALL minimumAge: 50 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: HÜMEYRA city: Nevşehir state: Nevşehi̇r zip: 50000 country: Turkey lat: 38.625 lon: 34.71222 hasResults: False
nctId: NCT06307769 id: 2024.02.42 briefTitle: Ten-meter Walking Test With Obstacle in Geriatric Individuals. overallStatus: RECRUITING date: 2024-03-05 date: 2024-05-15 date: 2024-05-25 date: 2024-03-13 date: 2024-03-13 name: Ataturk University class: OTHER briefSummary: Balance and fall problems are one of the most common geriatric syndromes in the elderly. Falls are one of the leading factors causing mortality in the elderly. One-third of individuals aged sixty-five and over fall once or more every year. When the causes of death in elderly individuals are examined; Accidents come in fifth place, and 2/3 of these accidents occur due to falls. The frequency of falls increases with age in 22% of individuals between the ages of 65-69. This rate is stated as 31% between the ages of seventy-five and seventy-nine, and 40% between the ages of 80-84.
Geriatric individuals may be at risk of falling in different situations, often inside and outside the home. Falls generally occur more frequently in indoor areas such as bathrooms, kitchens and bedrooms. In these areas, falls caused by potentially dangerous factors such as slippery floors, carpet edges, and high thresholds are more common. A frequent fall occurs when jumping over an obstacle. Factors such as poor balance, vision problems or reduced muscle strength when overcoming obstacles can increase the risk of falling in this situation. The ability of geriatric individuals to overcome obstacles during daily activities is an important factor determining quality of life. Climbing stairs or crossing high thresholds is an important part of daily living activities and poses a risk of falling. Therefore, determining the stair height threshold and assessing obstacle crossing skills should be considered effective measures. When the literature is examined, clinicians generally prefer simpler functional tests because assessments involving disabilities take a long time to be administered, involve some equipment, and also require training to perform the assessment. In the literature, there is currently a version of the functional tests that is applied only by adding obstacles to the timed get up and go test. Thanks to this test, the ability of geriatric individuals to overcome obstacles can be evaluated and people can be trained with this test. For this reason, we wanted to determine the suitability of the 10-meter walking test, which is frequently used in geriatric individuals, when applied with the addition of an obstacle. conditions: Geriatric conditions: Balance studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 60 type: ESTIMATED measure: Ten Meter Walk Test measure: Berg Balance Scale measure: Functional Reach Test measure: Timed up and go test sex: ALL minimumAge: 30 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ataturk University status: RECRUITING city: Erzurum country: Turkey name: Birol Önal, Dr. role: CONTACT phone: +904422311233 email: birol.onal@atauni.edu.tr lat: 39.90861 lon: 41.27694 hasResults: False
nctId: NCT06307756 id: SayıNo:521 briefTitle: The Effect of Music on Maternal Stress and Milk Amount overallStatus: RECRUITING date: 2023-11-15 date: 2024-04-15 date: 2024-06-15 date: 2024-03-13 date: 2024-03-13 name: Adiyaman University class: OTHER briefSummary: Premature babies who have to deal with life-threatening situations have to spend the first days of their lives in intensive care units. Mothers who plan to return home with their babies during the postpartum period may experience stress due to their children being monitored in intensive care. It is stated that mothers of babies in the neonatal intensive care unit experience stress and anxiety due to reasons such as being separated from their babies, the baby's illness, the baby's sensitive body structure, the baby's appearance and behavior, and the baby's dependence on devices. This stress experienced by mothers of premature babies can prevent mothers from providing enough milk to feed their babies. Mothers whose babies are in the neonatal intensive care unit cannot have adequate contact with their babies and cannot breastfeed; It causes insomnia, stress and anxiety, and the hormonal axis is disrupted, negatively affecting the amount of breast milk. In order to support the healing process of preterm babies, it is important to increase the amount of milk produced by mothers and increase the rate at which babies can receive breast milk. Music improves endothelial function by dilating the vessels; It has been reported that it reduces mental stress by increasing the release of nitrite oxide and endorphins and causes many physiological reactions such as a decrease in blood pressure and pulse. This study will examine the effect of music played to mothers with premature babies on maternal anxiety and the amount of breast milk. conditions: Amount of Breast Milk conditions: Maternal Anxiety Level studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 60 type: ESTIMATED name: Music group measure: amount of breast milk measured at the same time every day measure: State Anxiety Inventory sex: FEMALE minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Sağlık Bilimleri Üniversitesi Gazi Yaşargil Eğitim ve Araştırma Hastanesi status: RECRUITING city: Diyarbakır country: Turkey name: Özlem Sıdıka Kartal role: CONTACT phone: +90 05534452828 email: ozlem.kartal.002.@gmail.com lat: 37.91363 lon: 40.21721 hasResults: False
nctId: NCT06307743 id: RAPID-SAVE briefTitle: Rapid Local Ischemic Postconditioning in Acute Ischemic Stroke acronym: RAPID-SAVE overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2025-06-15 date: 2025-09-15 date: 2024-03-13 date: 2024-03-13 name: Shanghai Jiao Tong University Affiliated Sixth People's Hospital class: OTHER name: Zhangzhou Municipal Hospital of Fujian Province name: Shanghai East Hospital name: First People's Hospital of Hangzhou name: RenJi Hospital briefSummary: The objective of this clinical trial is to determine whether rapid local ischemic postconditioning (RL-IPostC) is effective in preventing brain edema and safe in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy. In this trial, researchers will block antegrade cerebral blood flow temporarily by the way of balloon inflation/deflation in AIS patients immediately after revascularization. It makes the ischemic reperfusion brain tissue have a capacity of adaptation through intermittent blood flow restoration. Researchers will evaluate the protective role and safety of different duration of balloon inflation/deflation. The optimal postconditioning intervention dose will be determined for further confirmative investigation. conditions: Acute Ischemic Stroke conditions: Mechanical Thrombectomy conditions: Ischemic Postconditioning conditions: Brain Edema studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 135 type: ESTIMATED name: rapid local ischemic postconditioning measure: Number of Participants without clinically meaningful cerebral swelling, significant increase in infarct volume from baseline and intervention-related serious adverse events. measure: Rate of participants without clinically meaningful cerebral swelling measure: Rate of participants with significant increase in infarct volume from baseline or intervention-related serious adverse events. measure: Change in volume of cerebrospinal fluid (∆CSF72) at 72 hours measure: Change of net water uptake (∆NWU24) at 24 hours measure: Change of net water uptake (∆NWU72) at 72 hours measure: Midline shift at 24 hours measure: Midline shift at 72 hours measure: Change of NIHSS at 24 hours measure: Early therapeutic response to treatment measure: Good outcome at 90 days measure: Excellent outcome at 90 days sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06307730 id: CHSD_0033_GERIATRIE briefTitle: Application of the Recommendations of the SPLIF (French Society of Infectious Pathology) in a Geriatric Population on the Duration of Treatment for Bacterial Pneumonia overallStatus: COMPLETED date: 2023-01-02 date: 2023-04-30 date: 2023-04-30 date: 2024-03-13 date: 2024-03-13 name: Centre Hospitalier de Saint-Denis class: OTHER briefSummary: Pneumopathy is the leading cause of death from infectious disease in the elderly. Prior to 2021, the recommended duration of antibiotic therapy for pneumonia, in adults, was 7 days.
The investigators offer a monocentric, retrospective, observational study of the geriatric hospital Casanova to assess the application of SPLIF recommendations in the geriatric population. conditions: Pneumonia, Bacterial conditions: Pneumopathy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 35 type: ACTUAL measure: Sex measure: Age measure: Weight measure: Phone Number measure: Origins measure: Autonomy in daily life's score before hospitalisation measure: Charlson's morbidity score sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre Hopitalier de Saint-Denis city: Saint-Denis state: Seine Saint Denis zip: 93200 country: France lat: 48.93326 lon: 2.36666 hasResults: False
nctId: NCT06307717 id: PLAGH-DA-002 briefTitle: Effects of Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety in Elderly Patients overallStatus: COMPLETED date: 2020-04-01 date: 2021-10-31 date: 2022-04-30 date: 2024-03-13 date: 2024-04-10 name: Chinese PLA General Hospital class: OTHER name: Beijing Tsinghua Changgeng Hospital name: Peking University First Hospital name: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School name: Xiangya Hospital of Central South University name: Beijing Anzhen Hospital name: Central South University name: Peking University People's Hospital name: Zhejiang University name: Fudan University name: Sun Yat-sen University name: Wuhan Union Hospital, China name: China-Japan Friendship Hospital name: The Affiliated Hospital Of Guizhou Medical University name: First Affiliated Hospital of Xinjiang Medical University name: First Affiliated Hospital of Guangxi Medical University name: Taihe Hospital briefSummary: This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of volatile anaesthetics on the incidence of postoperative depression and anxiety among elderly patients. conditions: Cohort Studies studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 8000 type: ACTUAL name: volatile anaesthetic (sevoflurane, isoflurane, desflurane) measure: Depression measure: Anxiety sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Chinese PLA General Hospital city: Beijing state: Beijing country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06307704 id: LUSPEEPORRPC briefTitle: Lung US for PEEP Optimization in Robotic Radical Prostatectomy or Cystectomy Patients overallStatus: RECRUITING date: 2024-03 date: 2024-09 date: 2024-09 date: 2024-03-13 date: 2024-03-15 name: Nazmy Edward Seif class: OTHER briefSummary: There is an increasing trend in the use of robotic-assisted radical prostatectomy or cystectomy (RARPC).
The aim of this study is to evaluate the effectiveness of intraoperative individualized lung ultrasound-guided stepwise PEEP optimization in patients undergoing RARPC on oxygenation, intraoperative and early postoperative pulmonary complications. conditions: Prostate Cancer conditions: Urinary Bladder Cancer conditions: Surgery conditions: Positive End Expiratory Pressure conditions: Lung Ultrasound studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 88 type: ESTIMATED name: Lung Ultrasound - guided Stepwise PEEP name: Standard Ventilation Protocol measure: Post-operative lung consolidation sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cairo University Hospitals status: RECRUITING city: Cairo country: Egypt name: Mustafa E Mohamed, MD role: CONTACT phone: 01140806330 phoneExt: +2 email: mustafaemam931@gmail.com name: Nazmy S Mikhael, MD role: CONTACT phone: 01227400808 phoneExt: +2 email: nazmy.edwar.seif@gmail.com lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06307691 id: 11423 briefTitle: Clinical and Radiographic Evaluation of Immediate Implant Placement Using Osseodensification Versus Traditional Drilling Protocol overallStatus: RECRUITING date: 2024-03-06 date: 2025-12-20 date: 2026-12-20 date: 2024-03-13 date: 2024-03-19 name: Cairo University class: OTHER briefSummary: For the purpose of the study, patients will be divided into two groups, i.e., Group A and Group B. In Group (A), 14 immediate implants will be placed using traditional drilling technique, while in Group (B), 14 immediate implants will be placed using OD drilling technique Osseodensification is a system for implant osteotomy preparation, it compresses the cancellous bone around the revolving drills. It largely improves low bone volume by physically increasing the interlocking between the bone and the implant surface. The Densah burs enhances bone density while generating the least amount of heat.
The objective of the current study is to compare between osseodensification drilling protocol versus traditional undersized drilling protocol in immediate implant placement in anterior maxillary region in terms of implant stability. conditions: Implant Complication studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: patients will be randomly selected into either group using computer generated randomization using (www.randomizer.org). The randomized numbers will be allocated to each site in each patient and will be placed in opaque, sealed and sequentially numbered envelopes. patients will be randomly allocated to test and control groups using randomization schedule.
* The biostatistician will be blinded whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 26 type: ESTIMATED name: Conventional drilling name: Osseodensification drilling measure: Implant stability quotient (ISQ) measure: Crestal bone level sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Faculty of Dentistry Cairo University status: RECRUITING city: Cairo country: Egypt name: Omar M Ibrahim, master role: CONTACT phone: 01000953710 phoneExt: 002 email: omar_ibrahim@dentistry.cu.edu.eg name: Omnia K Tawfik, PhD role: CONTACT phone: 01006002618 email: omnia.tawfik@dentistry.cu.edu.eg lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06307678 id: AtaturkU-DHF-MS-01 briefTitle: Effect of Calcium Silicate Based Root Canal Medicament on Inflammatory Mediators overallStatus: COMPLETED date: 2023-07-07 date: 2023-12-10 date: 2023-12-10 date: 2024-03-13 date: 2024-03-13 name: Ataturk University class: OTHER briefSummary: Calcium hydroxide is generally preferred in endodontics as an intracanal medicament because of its antimicrobial and biological effects. However, the antimicrobial effect of calcium hydroxide is limited.
The aim of this study was to investigate the effects of calcium silicate-based root canal medicament on the release of RANKL/OPG, TNF-α, PGE-2 and TGF-β1 in root canal treated teeth with periapical lesions. conditions: Periapical; Infection studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: two groups: group 1 calcium hydroxide based medicament (control group) group 2: calcium silicate based medicament primaryPurpose: TREATMENT masking: SINGLE maskingDescription: outcome assessments have performed by a investigator who was blinded to groups. whoMasked: OUTCOMES_ASSESSOR count: 60 type: ACTUAL name: Calcium Hydroxide name: Calcium Silicate measure: preoperative and postoperative levels of RANKL/OPG ratio measure: preoperative and postoperative levels of prostaglandinE2 (PGE2) ratio measure: preoperative and postoperative levels of TNF alpha ratio measure: preoperative and postoperative levels of TGF beta ratio measure: dependent variables (sex, age, teeth number, smoking habit) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ataturk University city: Erzurum zip: 25240 country: Turkey lat: 39.90861 lon: 41.27694 hasResults: False
nctId: NCT06307665 id: D6934C00001 briefTitle: Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma acronym: ACADIA overallStatus: NOT_YET_RECRUITING date: 2024-05-08 date: 2027-10-13 date: 2027-10-13 date: 2024-03-13 date: 2024-04-09 name: AstraZeneca class: INDUSTRY name: Parexel briefSummary: The purpose of this study is to compare the budesonide/albuterol metered-dose inhaler (BDA MDI) with albuterol sulfate metered-dose inhaler (AS MDI) administered as needed on severe asthma exacerbations in adolescent participants aged 12 to \< 18 years with a documented clinical diagnosis of asthma and at least one severe exacerbation in the prior year. conditions: Asthma studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 440 type: ESTIMATED name: BDA MDI name: AS MDI measure: Annualized rate of severe asthma exacerbations (AAER) measure: Time to first (TTF) severe asthma exacerbation measure: Annualized total systemic corticosteroids (SCS) exposure for treatment of asthma measure: Number of participants with adverse events (AEs) and severe adverse events (SAEs) measure: Maximum Observed Concentration (Cmax) measure: Area under plasma concentration-time curve from time 0 to last quantifiable concentration (AUClast) measure: Area under plasma concentration-time curve from time 0 to infinity (AUCinf) measure: Time to reach maximum concentration following drug administration (Tmax) measure: Time to reach maximum concentration following drug administration (Tlast) measure: Terminal elimination half-life (t½λz) measure: Terminal elimination rate constant (λz) measure: Apparent total body clearance (CL/F) measure: Apparent volume of distribution based on the terminal phase (Vz/F) sex: ALL minimumAge: 12 Years maximumAge: 17 Years stdAges: CHILD facility: Research Site city: White Marsh state: Maryland zip: 21162 country: United States lat: 39.38372 lon: -76.43218 hasResults: False
nctId: NCT06307639 id: MYMSwifee briefTitle: Seminal Levels of PGK2 and ACRV1 as Predictors of Micro-TESE Results in NOA overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-10-01 date: 2026-04-01 date: 2024-03-13 date: 2024-03-13 name: Assiut University class: OTHER briefSummary: * Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE).
* Correlate seminal levels of PGK2 and ACRV1 with sperm retrieval results and histopathology analysis of testicular biopsy samples. conditions: Male Infertility Due to Azoospermia studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 64 type: ESTIMATED name: Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE). measure: Know more about the functional role of PGK2 and ACRV1 in the process of spermatogenesis. measure: Detect if PGK2 and/or AVRV1 level can used as predictor for spermatogenesis in infertile men with non-obstructive azoospermia undergoing Testicular Sperm Extraction. sex: MALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT hasResults: False
nctId: NCT06307626 id: ARGX-113-2309 id: 2023-509198-22-00 type: CTIS briefTitle: A Study of Efgartigimod PH20 SC Given by Prefilled Syringe in Adults With Thyroid Eye Disease. overallStatus: RECRUITING date: 2024-03-28 date: 2026-02 date: 2027-10 date: 2024-03-13 date: 2024-04-04 name: argenx class: INDUSTRY briefSummary: This study aims to evaluate the efficacy, safety and tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of efgartigimod PH20 SC in participants with active, moderate-to-severe TED, compared with placebo PH20 SC.
After an up to 28-day screening period, eligible participants will be randomized in a 2:1 ratio to receive efgartigimod PH20 SC or placebo PH20 SC, respectively. Study drug will be administered subcutaneously during the 24-week double-blinded treatment period (DBTP). At the end of the DBTP (week 24), proptosis responders will enter a follow-up observational period (52 weeks) to assess the safety, tolerability, and durability of efgartigimod PH20 SC treatment while off therapy. Proptosis nonresponders and participants who have proptosis relapse during the 52-week follow-up observational period will receive open-label treatment with efgartigimod PH20 SC for up to 24 weeks. conditions: Thyroid Eye Disease studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 108 type: ESTIMATED name: Efgartigimod PH20 SC name: Placebo PH20 SC measure: Percentage of participants who were proptosis responders measure: Change in proptosis measurement in the study eye from baseline measure: Change in the total Graves' Orbitopathy Quality of Life (GO-QoL) score from baseline measure: Percentage of participants with a resolution of diplopia (responders) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Advanced Research status: RECRUITING city: Boynton Beach state: Florida zip: 33437 country: United States name: Sirtaz S. Sibia, MD role: CONTACT phone: 857-350-4834 email: clinicaltrials@argenx.com lat: 26.52535 lon: -80.06643 hasResults: False
nctId: NCT06307613 id: ARGX-113-2301 id: 2023-509197-35-00 type: CTIS briefTitle: A Study of Efgartigimod PH20 SC Given by Prefilled Syringe in Adults With Thyroid Eye Disease overallStatus: RECRUITING date: 2024-03-27 date: 2026-02 date: 2027-10 date: 2024-03-13 date: 2024-04-04 name: argenx class: INDUSTRY briefSummary: This study aims to evaluate the efficacy, safety and tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of efgartigimod PH20 SC in participants with active, moderate-to-severe TED, compared with placebo PH20 SC.