hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06370806 id: INTERAPNEA-Women briefTitle: Lifestyle Intervention for Obstructive Sleep Apnea in Women acronym: INTERAPNEA-W overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-01 date: 2025-12-01 date: 2024-04-17 date: 2024-04-17 name: Universidad de Granada class: OTHER name: Fundación BBVA name: Universidad Loyola Andalucia briefSummary: Obesity is a major risk factor for obstructive sleep apnoea (OSA), the most common sleep-disordered breathing related to neurocognitive and metabolic syndromes, type II diabetes, and cardiovascular diseases. Although strongly recommended for this condition, there are no studies on the effectiveness of an interdisciplinary weight loss and lifestyle intervention including nutrition, exercise, sleep hygiene, and smoking and alcohol cessation in women. INTERAPNEA-Women is a randomized controlled trial with a two-arm parallel design aimed at determining the effects of an interdisciplinary tailored weight loss and lifestyle intervention on OSA outcomes. The study will include 180 females aged 18-65 with a body mass index of ≥25 kg/m2 and severe to moderate OSA randomly assigned to usual care (i.e., continuous positive airway pressure), or interdisciplinary weight loss and lifestyle intervention combined with usual care. Outcomes will be measured at baseline, intervention end-point, and six-month post-intervention, including apnoea-hypopnoea index (primary outcome), other neurophysical and cardiorespiratory polysomnographic outcomes, sleep quality, daily functioning and mood, body weight and composition, physical fitness, blood biomarkers, and health-related quality of life. INTERAPNEA may serve to establish a cost-effective treatment not only for the improvement of OSA and its vast and severe comorbidities, but also for a potential remission of this condition. conditions: Obstructive Sleep Apnea studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 180 type: ESTIMATED name: Weight loss and lifestyle intervention measure: Apnoea-hypopnoea index (AHI) measure: Oxygen desaturation index (ODI) measure: Oxygen saturation (SaO2) mean measure: Oxygen saturation (SaO2) nadir measure: Sleep efficiency measure: Light sleep (N1 and N2 stages) measure: Deep sleep (N3 stage) measure: Rapid eye movement (REM) sleep measure: Excessive daytime sleepiness (EDS) measure: Sleep Quality measure: Wake After Sleep Onset (WASO) measure: Fat mass (kg) measure: Visceral adipose tisue (g) measure: Body weight (kg) measure: Neck circumference (cm) measure: Chest circumference (cm) measure: Waist circumference (cm) measure: Mean blood pressure (mm HG) measure: Plasma glucose (mg/dL) measure: Change in total cholesterol (mg/dL) from baseline to post-intervention measure: Change in total triglycerides (mg/dL) from baseline to post-intervention sex: FEMALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06370793 id: NBU-2024-011 briefTitle: Ningbo Severe Mental Disorders Cohort acronym: NEED overallStatus: ACTIVE_NOT_RECRUITING date: 2018-07-01 date: 2023-12-31 date: 2026-12-31 date: 2024-04-17 date: 2024-04-18 name: Ningbo University class: OTHER name: The Affiliated Kangning Hospital of Ningbo University briefSummary: In recent years, the prevalence of severe mental disorders in China has continued to grow, and the burden of disease in society has continued to rise. In order to improve the prognosis of patients with severe mental disorders and reduce the risk of disease relapse or readmission, researchers established a cohort based on the Ningbo Mental Health Information System in Ningbo, a sub-provincial city in the southern wing of the Yangtze River Delta of China, with a resident population of more than 9 million, and linked it to the residents' health records, and through the data linkage obtained data on patients in the full cycle of pre-diagnosis, diagnosis, follow-up, disease changes and death, realising full-cycle management of patients with severe mental disorders.
Currently, NEED has accumulated data on more than 50,000 patients with severe mental disorders and obtained multi-dimensional longitudinal information through long-term follow-up and data linkage. All diseases follow the World Health Organization International Classification of Diseases 10th Edition (ICD-10) for clinical coding, and available data include baseline demographics, past history, family history, social functioning deficit screening scale scores, risk assessment, and so on and longitudinal health information from electronic health records (EHR), providing a solid data base for future real-world studies. conditions: Severe Mental Disorder conditions: Schizophrenia conditions: Bipolar Disorder conditions: Schizo-Affective Psychosis conditions: Paranoid Psychoses conditions: Mental Retardation conditions: Epileptic Psychosis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 57212 type: ACTUAL name: Patient with severe mental disorder without intervention measure: Risk of circulatory system diseases measure: Risk of endocrine system diseases measure: Risk of pulmonary system and allergy diseases measure: Risk of gastrointestinal system diseases measure: Risk of musculoskeletal system diseases measure: Risk of urogenital system diseases measure: Risk of hematological system diseases measure: Risk of cancers measure: Risk of neurological system diseases measure: Risk of suicide measure: Risk of violence sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Ningbo Mental Health Information System city: Ningbo state: Zhejiang zip: 315000 country: China lat: 29.87819 lon: 121.54945 hasResults: False
nctId: NCT06370780 id: 5UG3AI176592-02 type: NIH link: https://reporter.nih.gov/quickSearch/5UG3AI176592-02 briefTitle: Exploring, Predicting, and Intervening on Long-term Viral Suppression Electronically acronym: EPI-LoVE overallStatus: RECRUITING date: 2024-02-09 date: 2025-04-30 date: 2025-04-30 date: 2024-04-17 date: 2024-04-26 name: University of California, Los Angeles class: OTHER name: Florida State University name: University of California, Irvine name: University of North Carolina, Chapel Hill name: AIDS Healthcare Foundation briefSummary: Despite the widespread availability of effective antiretroviral therapy (ART) in the United States, there remains significant numbers of people living with HIV (PLWH) who fail to achieve and or maintain viral suppression (VS). Disparities persist with the lowest levels of VS among Black individuals, people who use drugs, youth ages 18-24 and people residing in rural areas. Investigators will examine the syndemics underlying these outcomes including substance use, mental health, and barriers to HIV care including racial discrimination, stigma and rural isolation. conditions: HIV Infections studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE maskingDescription: N/A - all participants get the app count: 1000 type: ESTIMATED name: EPI LOVE measure: Incidence of HIV Viral Suppression measure: Level of Adherence to HIV medication measure: Level of Adherence based on HIV appointments sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of California, Los Angeles status: RECRUITING city: Los Angeles state: California zip: 90095 country: United States name: Pamina Gorbach, DrPh, MHS role: CONTACT phone: 310-794-2555 email: pgorbach@ucla.edu name: Valerie El-Alfi, MA role: CONTACT email: velalfi@mednet.ucla.edu lat: 34.05223 lon: -118.24368 hasResults: False
nctId: NCT06370767 id: 25634 briefTitle: Peer Facilitated Waitlist Controlled Transportation Study overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-05 date: 2024-04-17 date: 2024-04-17 name: Temple University class: OTHER briefSummary: The goal of this clinical trial is to test the effectiveness of a peer-facilitated travel intervention in adults with serious mental illnesses. This project aims to address the following hypotheses:
Participants will be assigned to an 8-week travel-training intervention either using a bike-share program or public transportation. All participants will complete three data-collection research interviews. conditions: Serious Mental Illness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants will be randomly assigned to either start the intervention program immediately, or be placed on an 8-week waitlist. Once randomized, the participant will again be randomized into a treatment condition: 1) peer-mediated bikeshare training intervention; or 2) peer-mediated public travel training intervention. 20 participants from each condition who have not opted out of being in the GPS subsample will be randomly assigned to be invited to a GPS subgroup. primaryPurpose: OTHER masking: NONE count: 180 type: ESTIMATED name: Bike-Share Travel Training name: Public Transportation Travel Training measure: Temple University Community Participation Measure measure: LASA Sedentary Behaviors Questionnaire measure: Transportation Appraisal Scale measure: Indego Skills Survey measure: SEPTA Skills Survey measure: University of California, San Diego Performance-Based Skills Assessment (UPSA- Modified) measure: National Household Travel Survey measure: GPS measure: Internalized Stigma of Mental Illness Inventory (ISMI) (Brief Version) measure: University of California, Los Angeles, Loneliness Scale measure: Pearlin Mastery Scale (Coping) measure: SF- 36 v2 measure: The PERMA - Profiler Measure measure: Recovery Assessment Scale (RAS) measure: Group Identification Scale (GIS) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-12-07 uploadDate: 2024-04-10T09:43 filename: Prot_SAP_000.pdf size: 450285 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-12-07 uploadDate: 2024-04-10T09:43 filename: ICF_001.pdf size: 235105 hasResults: False
nctId: NCT06370754 id: 2401289-19-2403 briefTitle: Newly Emerging Immunotherapy for Pancreatic Cancer Treatment acronym: FD-IMPACT overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2026-04-30 date: 2027-04-30 date: 2024-04-17 date: 2024-04-17 name: Fudan University class: OTHER briefSummary: This is a Phase Ib/II platform clinical study to evaluate the initial efficacy and safety of different novel immunotherapies in patients with advanced pancreatic cancer. conditions: Pancreatic Cancer studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 117 type: ESTIMATED name: JS001 name: JS004 name: JS007 name: JS015 name: Irinotecan Liposome Injection name: 5-Fluorouracil (5-FU) name: Leucovorin (LV) name: Nab paclitaxel name: Gemcitabine measure: Incidence of dose-limiting toxicity (DLT) (phase IB) measure: Objective Response Rate (ORR) (phase II) measure: Objective Response Rate (ORR) (phase IB) measure: Disease control rate (DCR) measure: Duration of Response (DOR) measure: Progression free survival (PFS) measure: Overall Survival (OS) measure: Number of Participants With Abnormal Laboratory Values and/or Adverse Events That Are Related to Treatment sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center; Pancreatic Cancer Institute, Fudan University city: Shanghai state: Shanghai zip: 200032 country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06370741 id: OkanUni. briefTitle: Effect of Stretching Exercises on Plantar Fascia overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-05 date: 2024-06 date: 2024-04-17 date: 2024-04-17 name: Okan University class: OTHER briefSummary: The plantar fascia (PF) extends over the calcaneal bone with a thin band corresponding to the calcaneal periosteum, continuing as the paratenon of the Achilles tendon.The triceps surae complex, serving as the main extensor and propulsion system of the foot, involves the Achilles tendon, posterior part of the calcaneus, and Plantar Aponeurosis, all integrated with the fibrous skeleton of the triceps surae. Plantar fasciitis, a prevalent musculoskeletal condition affecting individuals of various ages and activity levels (Hye Chang Rhim), is a primary cause of heel pain in adults. Studies have identified the superior efficacy of stretching protocols targeting the Achilles tendon and/or plantar fascia compared to alternative treatments. However, the limitations of traditional approaches become apparent when considering the intricate biomechanics of the foot and ankle. Conventional calf stretches often prove inadequate for addressing its specific lengthening requirements. While contemporary methods like PF-Specific Stretching integrate plantar fascia and calf stretches, their reliance on individual upper extremity strength introduces potential limitations.
Myotonometry is a convenient method to assess the stiffness of the plantar fascia because it is cheap, simple and fast. Previous studies have shown that MyotonPRO can reliably assess the stiffness of the plantar fascia. Although the exact effect of stretching on the biomechanical properties of the plantar fascia is not known, it will be determined whether stretching with an instrument to be designed will have an effect and which method is more effective with or without an instrument. conditions: Stretch conditions: Plantar Fascia; Contracture conditions: Fasciitis, Plantar studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Pilot study primaryPurpose: DEVICE_FEASIBILITY masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 10 type: ESTIMATED name: Stretching with/without device measure: Plantar Fascia Mechanical Properties sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06370728 id: 18621 id: J2A-MC-GZPJ type: OTHER domain: Eli Lilly and Company briefTitle: A Drug-Drug Interaction (DDI) Study of Orforglipron With Carbamazepine in Healthy Participants overallStatus: NOT_YET_RECRUITING date: 2024-05-03 date: 2024-07-15 date: 2024-07-15 date: 2024-04-17 date: 2024-04-29 name: Eli Lilly and Company class: INDUSTRY briefSummary: The main purpose of this study is to assess the effect of carbamazepine on the amount of orforglipron in the bloodstream and how long it takes the body to get rid of orforglipron when given orally in healthy study participants. The safety and tolerability of orforglipron and carbamazepine when given separately or together will also be evaluated. The study may last up to approximately 77 days for each participant. conditions: Healthy studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 30 type: ESTIMATED name: Orforglipron name: Carbamazepine measure: Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve from Time Zero to Infinity (AUC [0-∞]) of Orforglipron measure: PK: Area Under the Concentration Versus Time Curve from Time Zero to the Last Measurable Concentration (AUC[0-tlast]) of Orforglipron measure: PK: Maximum Observed Concentration (Cmax) of Orforglipron sex: ALL minimumAge: 21 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ICON Early Phase Services city: San Antonio state: Texas zip: 78209 country: United States role: CONTACT phone: 210-255-5437 name: Robert Bass role: PRINCIPAL_INVESTIGATOR lat: 29.42412 lon: -98.49363 hasResults: False
nctId: NCT06370715 id: 18269 id: I8B-MC-ITTA type: OTHER domain: Eli Lilly and Company briefTitle: A Study of LY900014 in Adult Participants With Type 2 Diabetes Mellitus in India overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-07 date: 2025-07 date: 2024-04-17 date: 2024-04-17 name: Eli Lilly and Company class: INDUSTRY name: Cipla Ltd. briefSummary: The purpose of this study is to assess the safety of insulin lispro-aabc in adult participants with Type 2 diabetes mellitus in India.
nctId: NCT06370702 id: 23-054 briefTitle: Evaluating the Use of Grip Exercises to Decrease Deep Vein Thrombosis in Adult Patients With PICC Lines overallStatus: RECRUITING date: 2023-10-06 date: 2026-12-31 date: 2027-06-30 date: 2024-04-17 date: 2024-04-17 name: TriHealth Inc. class: OTHER briefSummary: Patients who have a peripherally-inserted central catheter (PICC) placed are at a risk of developing a deep vein thrombosis (DVT). At TriHealth, approximately 2-4 patients per month who have a PICC placed experience a subsequent DVT. One innovative way to possibly mitigate the risk of DVTs is hand grip exercises. The current study will be the first study to evaluate hand grip exercises for the prevention of DVTs in adult patients hospitalized in the United States. conditions: Deep Vein Thrombosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 2500 type: ESTIMATED name: Handgrip Exercises measure: Deep vein thrombosis sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Good Samaritan Hospital status: RECRUITING city: Cincinnati state: Ohio zip: 45220 country: United States name: Rachel Baker, PhD, RN role: CONTACT phone: 513-569-6191 email: Rachel_Baker2@trihealth.com lat: 39.12713 lon: -84.51435 facility: Bethesda North Hospital status: RECRUITING city: Cincinnati state: Ohio zip: 45242 country: United States name: Rachel Baker, PhD, RN role: CONTACT phone: 513-569-6191 email: Rachel_Baker2@trihealth.com lat: 39.12713 lon: -84.51435 hasResults: False
nctId: NCT06370689 id: PRE-OX briefTitle: Comparison of Three Pre-oxygenation Strategies overallStatus: NOT_YET_RECRUITING date: 2024-05-23 date: 2024-12-31 date: 2025-07-30 date: 2024-04-17 date: 2024-04-17 name: Institute of Mountain Emergency Medicine class: OTHER briefSummary: Study objective: Comparing the efficacy of three different preoxygenation strategies, i.e. non-rebreather face mask (NRM), bag-valve-mask (BVM) with and BVM without additional positive end-expiratory pressure (PEEP) in three subgroups of spontaneously breathing volunteers.
After informed consent and a medical check-up, baseline measurements will be done for 10 minutes (peripheral oxygen saturation SpO2, ORI, regional ventilation). Then the participants will undergo 3 different preoxygenation sessions with the 3 interfaces (i.e. non-rebreather facemask with reservoir and a bag-valve-mask with and without PEEP) in a randomized order and a 20 min washout between the sessions. Each preoxygenation session is conducted in a supine position and will be proceeded until the measured FeO2 (end expiratory O2 fraction) reaches 90% or up to a maximum time of 3 min. Afterwards 10 min of SpO2, ORI and regional ventilation measurements will follow. conditions: Emergencies conditions: Anesthesia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: NONE count: 45 type: ESTIMATED name: Preoxygenation measure: Difference in Oxygen Reserve index (ORi) after 3 minutes of preoxygenation measure: Difference in expiratory oxygen concentration (FeO2) after 3 minutes of preoxygenation measure: Time to Oxygen Reserve index (ORi) = 1.0 sex: ALL minimumAge: 6 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06370676 id: ESO-TIP briefTitle: Accuracy of Core Body Temperature Measurement Depending on Oesophageal Probe Tip Location acronym: ESO-TIP overallStatus: NOT_YET_RECRUITING date: 2024-05-23 date: 2024-12-31 date: 2025-07-30 date: 2024-04-17 date: 2024-04-17 name: Institute of Mountain Emergency Medicine class: OTHER briefSummary: Background An accurate measurement of the core body temperature (CBT) is of pivotal importance in the management of severely hypothermic patients. For instance, triage decisions for or against extracorporeal rewarming of hypothermic patients in cardiac arrest strongly depend on CBT. CBT measurement with an oesophageal probe is currently considered the gold standard in hypothermic patients with a secured airway in the prehospital setting, with the tip of the probe placed into the distal third of the oesophagus (i.e., posteriorly to the heart and distal to the tracheal bifurcation). However, the correct placement of the probe tip cannot be verified in the prehospital setting, and it is unknown how incorrect placement affects temperature readings.
Hypothesis and aim The investigators hypothesise that an incorrect placement of the oesophageal temperature probe tip could lead to inaccurate measurements (i.e., temperature readings not reflecting the real CBT). Particularly, a tip location too high in the oesophagus in close proximity to the trachea could lead to falsely low temperature readings, especially when the patient is ventilated with cold air. The aim of the proposed study is to investigate the influence of oesophageal temperature probe tip location on CBT measurement.
Methods Experimental, interventional study on 16 healthy volunteers. During the test oesophageal temperature is measured while participants are breathing ambient air first at 20°C (baseline) followed by cold (-20°C) ambient air in supine position for 20 minutes each test in an environmental simulator (terraXcube). Each participant repeats the 20-min test two times with the oesophageal temperature probe tip placed either in the lower third of the oesophagus (i.e., correct position) or too high in the oesophagus, i.e. behind the trachea. conditions: Emergencies conditions: Hypothermia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: DIAGNOSTIC masking: SINGLE maskingDescription: The participant is blinded for the location of the oesophageal temperature probe tip. whoMasked: PARTICIPANT count: 16 type: ESTIMATED name: Oesophageal temperature measurement measure: Difference in core body temperature between the two tip positions sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False