hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06262139 id: MT218-002 briefTitle: Evaluation of a Targeted Magnetic Resonance Imaging Contrast Agent in Prostate Cancer Patients overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-12 date: 2025-09 date: 2024-02-15 date: 2024-04-29 name: Molecular Theranostics LLC class: INDUSTRY name: Emory University briefSummary: This phase 1b open label, dose-escalating investigation study is to evaluate the dose dependent initial efficacy of the use of MT218 injection for biomarker targeted MR molecular imaging (MRMI) of prostate cancer in patients scheduled for radical prostatectomy. conditions: MRI Scan studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SEQUENTIAL interventionModelDescription: prostate cancer patients primaryPurpose: DIAGNOSTIC masking: NONE count: 12 type: ESTIMATED name: MT218 injection measure: Detection of aggressive prostate cancer (Gleason score 8 to 10) using peptide based MRI contrast agent (MT218) with comparing the previous clinical mpMRI using the clinical standard MRI contrast agent and PSMA-PET/CT sex: MALE minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Emory University city: Atlanta state: Georgia zip: 30322 country: United States lat: 33.749 lon: -84.38798 hasResults: False
nctId: NCT06262126 id: 23-012673 briefTitle: Virtual Reality for Non-cardiac Chest Pain overallStatus: RECRUITING date: 2024-02-14 date: 2024-12 date: 2025-01 date: 2024-02-15 date: 2024-04-17 name: Mayo Clinic class: OTHER briefSummary: The purpose of this study is to determine if virtual reality (VR) will improve symptoms in non-cardiac chest pain (NCCP). conditions: Gastrointestinal Diseases conditions: Chest Pain studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 10 type: ESTIMATED name: Virtual Reality measure: Measure changes in GERD symptoms using the GERDQ questionnare measure: Measure changes in GERD quality of life using the GERD-HRQL questionnaire measure: Measure changes in esophageal symptom specific anxiety using the EHAS questionnaire measure: Measure changes in GI symptom severity using the PAGI-SYM questionnaire measure: Measure changes in GI related patient assessment of quality of life using PAGI-QOL measure: Measure changes in anxiety and depression using the HADs scale measure: Measure changes in resilience using the brief resilience scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mayo Clinic Florida status: RECRUITING city: Jacksonville state: Florida zip: 32224 country: United States name: Wendi Lehman role: CONTACT phone: 904-953-8742 email: Lehman.Wendi@mayo.edu lat: 30.33218 lon: -81.65565 hasResults: False
nctId: NCT06262113 id: 2024P000392 id: AD-2022C2-24790 type: OTHER_GRANT domain: PCORI briefTitle: A Decentralized Clinical Trial to Promote Evidence-Based Care for Underserved Patients With Neurofibromatosis 1 overallStatus: NOT_YET_RECRUITING date: 2024-11 date: 2026-06 date: 2026-08 date: 2024-02-15 date: 2024-02-15 name: Massachusetts General Hospital class: OTHER name: Patient-Centered Outcomes Research Institute briefSummary: The goal of this fully decentralized, randomized controlled trial is to compare the efficacy of two educational interventions for individuals with Neurofibromatosis 1 (NF1). The primary objective of the study is to determine which intervention leads to higher rates of evidenced-based health screenings for NF1 patients in primary care settings.
Adults with NF1 and parents/guardians of children with NF1 from across the U.S. who do not go to a specialized NF clinic and who have an upcoming annual wellness visits scheduled with a primary care provider (PCP) are eligible to enroll in the study. conditions: Neurofibromatosis 1 studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 360 type: ESTIMATED name: Letters about NF1 Care (Content Type 1) name: Letters about NF1 Care (Content Type 2) measure: Receipt of Recommended NF1 Health Screenings measure: Patient Activation Measure® measure: Consumer Assessment of Healthcare Providers and Systems (CAHPS®) Clinician and Group Survey Version 4.0 (Beta): Rating of the Visit measure: Consumer Assessment of Healthcare Providers and Systems (CAHPS®) Clinician and Group Survey Version 4.0 (Beta): How Well Providers Communicate With Patients Subscale measure: Consumer Assessment of Healthcare Providers and Systems (CAHPS®) Clinician and Group Survey Version 4.0 (Beta): Providers' Use of Information to Coordinate Patient Care Subscale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Massachusetts General Hospital city: Boston state: Massachusetts zip: 02114 country: United States lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06262100 id: EYL_23_01 briefTitle: Lubricating Effectiveness of Carragelose Eye Drops in Patients Affected by Mild to Moderate Dry Eye overallStatus: RECRUITING date: 2024-01-15 date: 2024-07-30 date: 2024-12-15 date: 2024-02-15 date: 2024-02-15 name: Marinomed Biotech AG class: INDUSTRY briefSummary: Patients suffering from dry eye syndrom will treat their eyes with Carragelose® eye drops three times a day for 28 days. Before, in the middle and at the end of the treament period patients will be exposed to adverse conditions to challenge dry eye symptoms. Patient will record their occular symptoms and ophthalmic examinations will be performed by an ophthalmologist. Differences between before and after treatment will be assessed. conditions: Dry Eye Syndromes studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Carragelose measure: Change in dry eye symptoms measure: Responder analysis sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IOBA,Ocular Surface Research Group, University of Valladolid status: RECRUITING city: Valladolid zip: 47011 country: Spain name: Marta Balanco Vázquez, PhD role: CONTACT phone: C email: mblancov@ioba.med.uva.es name: Margarita Calogne, PhD role: CONTACT phone: V email: calogne@ioba.med.uva.es lat: 41.65518 lon: -4.72372 hasResults: False
nctId: NCT06262087 id: MU-CIRB 2023/044.2203 briefTitle: The Combined FIFA 11+ and Change of Direction Training overallStatus: RECRUITING date: 2024-02-15 date: 2024-06 date: 2024-12 date: 2024-02-15 date: 2024-03-15 name: Mahidol University class: OTHER briefSummary: The study has investigated the effects of adding change of direction (COD) training to the FIFA 11+ on lower extremity performance in soccer players. The investigators are interested in knee valgus angle during cutting which is typically suggested as a critical risk of anterior cruciate ligament injury. Peak knee valgus angle during cutting is expected to reduce immediately after adding COD training to the FIFA 11+. conditions: Rehabilitation conditions: Physical Therapy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Change of direction training name: FIFA 11+ program measure: Peak knee valgus angle sex: MALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: FFC league in Cambodia status: RECRUITING city: Phnom Penh country: Cambodia name: Komsak Sinsurin, Ph.D. role: CONTACT phone: +66 024415450 phoneExt: 20605 email: komsak.sin@mahidol.edu name: Chanteng Huoth, M.Sc. role: PRINCIPAL_INVESTIGATOR lat: 11.56245 lon: 104.91601 hasResults: False
nctId: NCT06262074 id: IEC-2418 briefTitle: Effect of Structured Training Program in Diabetic Patients overallStatus: RECRUITING date: 2024-02-08 date: 2024-02-08 date: 2024-03-31 date: 2024-02-15 date: 2024-02-15 name: Maharishi Markendeswar University (Deemed to be University) class: OTHER briefSummary: Diabetic neuropathy, a challenging condition resulting from poorly managed type-1 or type-2 diabetes mellitus, often proves resistant to conventional medications when it comes to alleviating the associated symptoms. In such cases, implementing a well-organized exercise regimen has proven beneficial in mitigating diverse symptoms associated with the condition and enhancing the overall quality of life for affected individuals. conditions: Diabetic Peripheral Neuropathy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: Structured Exercise Program name: Non structured exercise program measure: Michigan neuropathy screening instrument (MNSI) measure: Biothesiometer measure: NeuroQoL measure: NPRS sex: ALL minimumAge: 40 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: MMIPR status: RECRUITING city: Ambala state: Haryana zip: 133207 country: India name: Subhashish Chatterjee, MPT(NEURO) role: CONTACT phone: +918950037407 email: subhasishphysio@gmail.com name: Subhashish Chatterjee, MPT role: PRINCIPAL_INVESTIGATOR lat: 30.36099 lon: 76.79782 hasResults: False
nctId: NCT06262061 id: PRO-TBI-FS briefTitle: Propranolol for the Treatment of Traumatic Brain Injury overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-04 date: 2025-09 date: 2024-02-15 date: 2024-02-15 name: London Health Sciences Centre class: OTHER briefSummary: Traumatic brain injury (TBI) is a leading cause of global disease and directly affects over 1.5 million Canadians, with 165 000 TBIs occurring yearly in Canada. Despite the burden of TBIs, there are limited treatment options available and current treatments generally focus on supportive care. The aim of TBI treatment is reduce inflammation and damage occurring after the TBI (secondary injury).
Beta- blockers (BBs) are medications commonly used to block the actions of endogenous catecholamines- hormones that are thought to contribute to secondary injury within brain tissue. This reduces metabolic demand in the vulnerable, injured brain. BBs have been studied in several retrospective trials and one single-center, non- blinded randomized controlled study. These results point towards a benefit to the use of BBs in TBI but need to be confirmed in a rigorous manner before they are widely adopted.
The current study aims to assess the feasibility of a single centre randomized controlled trial of BBs versus placebo to treat moderate to severe TBI. This feasibility trial will inform the planning of a large multi-center study powered to detect a difference in cognitive outcomes and mortality. It also will allow the investigators to gather biologic samples for measuring serum catecholamines and inflammatory mediators to better understand the basic science mechanisms of BBs in this patient population; and to assess the feasibility of using the Cambridge Battery to assess cognitive outcomes of trial participants. conditions: TBI (Traumatic Brain Injury) studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Prospective, single- center double- blinded randomized control trial comparing placebo to propranolol for the treatment of moderate- severe traumatic brain injury. primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Patients will be randomized in a 1:1 allocation to either the propranolol or control group. Our hospital pharmacy will control the randomization procedure. The propranolol group will receive over-encapsulated whole marketed tablets comprised of 20mg oral propranolol \[USP grade\] filled with lactose monohydrate powder \[NF grade\] encapsulated with opaque gelatin capsules twice daily for 14 days (or until hospital discharge or death). The control group will receive an oral placebo comprised of lactose monohydrate powder \[NF grade\] encapsulated with indistinguishable opaque gelatin capsules. The pharmacy will have access to the randomization key. Nursing staff will remove the gelatin capsule casing and dissolve the trial drug \& placebo in sterile water prior to administering it enterally via a feeding tube to the participants. Aside from the nursing staff, the participants, research team, and remainder of the clinical care teams will all remain blinded to treatment allocation. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Propranolol name: Placebo measure: Hospital Mortality measure: Cognitive function measure: Catecholamines/Inflammatory markers sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06262048 id: PrePOURTS briefTitle: Prevention of Post Operative Urinary Retention After Thoracic Surgery Trial acronym: PrePOURTS overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-30 date: 2025-05-31 date: 2024-02-15 date: 2024-02-15 name: Lawson Health Research Institute class: OTHER briefSummary: The objectives of this study are to determine the efficacy of tamsulosin compared to placebo in reducing post-operative urinary retention and improving other clinical outcomes in people undergoing pulmonary surgery. conditions: Urinary Retention Postoperative studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: single centre, double blind randomized controlled trial primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 64 type: ESTIMATED name: Tamsulosin Hydrochloride name: Placebo measure: Rate of post operative urinary retention measure: Rate of Straight Catheterizations measure: Rate of Indwelling Catheterizations measure: Time to first catheterization measure: Treatment Related Adverse Events measure: Catheter related complications measure: Length of stay sex: ALL minimumAge: 40 Years stdAges: ADULT stdAges: OLDER_ADULT facility: London Health Sciences Centre city: London state: Ontario zip: N6A 5W9 country: Canada lat: 42.98339 lon: -81.23304 hasResults: False
nctId: NCT06262035 id: 2023-02987-01 briefTitle: Transcriptome, Proteome and Microbiome Profile in Periodontal and Peri-implant Diseases overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2028-12-31 date: 2030-12-31 date: 2024-02-15 date: 2024-02-15 name: Karolinska Institutet class: OTHER briefSummary: 1. To investigate the transcriptomic profile of periodontitis and peri-implantitis. Patients with defined periodontitis, at two non-adjacent teeth and peri-implantitis at ≥ one implant in function of ≥ one year, will be included to investigate the gene expression profile in tissue affected by periodontitis and peri-implantitis. Subjects will undergo a full-mouth examination performed by a calibrated examiner, including assessment of caries, bone abnormalities and infections according to intraoral x-ray, plaque index and pocket probing depth, suppuration, bleeding on probing, alveolar bone loss, and the number of teeth. During surgical intervention, tissue biopsies (two specimens per site) will be collected by a periodontist from site with ongoing periodontitis and site from ongoing peri-implantitis.
2. To study the microbiome and biomarker profile associated with periodontitis and peri- implantitis. Patients with defined periodontitis, at two non-adjacent teeth and peri-implantitis at ≥ one implant in function of ≥ one year, will be included in this study to determine the bacteria composition, cytokine profile and inflammatory biomarkers profile. Subjects will undergo a full-mouth examination performed by a calibrated examiner, including assessment of caries, bone abnormalities and infections according to intraoral x-ray, plaque index and pocket probing depth, suppuration, bleeding on probing, alveolar bone loss, and number of teeth. Peri-implant crevicular fluid (PICF), gingival crevicular fluid (GCF), saliva and submucosal/subgingival plaque will be collected.The presence and composition of periodontal and peri-implant plaque samples are investigated. conditions: Peri-implantitis conditions: Periodontitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 30 type: ESTIMATED name: Periodontitis and Peri-implantitis measure: Protein levels in peri-implantitis and periodontitis measure: Microbiome composition in peri-implantitis and periodontitis using 16S-rRNA sequencing method. measure: Gene expression profile in peri-implantitis and periodontitis. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06262022 id: KaramanogluMehmetbeyUFGok briefTitle: The Effect of Cold Application on Pain Level, Edema and Drainage Amount overallStatus: RECRUITING date: 2024-01-15 date: 2024-04-30 date: 2024-04-30 date: 2024-02-15 date: 2024-02-15 name: Karamanoğlu Mehmetbey University class: OTHER name: Karaman Training and Research Hospital briefSummary: In this study, we aimed to investigate the effect of cold application applied for 20 minutes every hour for 8 hours on the first day, second and third days after total hip arthroplasty with gel pads, on the pain level, edema and drainage amount of total hip arthroplasty patients. The main question\[s\]it aims to answer are:
* Is there a difference between the amount of drainage of patients in the control and cold application arms? This study was planned as a prospective, parallel, two-arm (1:1) randomized controlled trial (RCT). conditions: Cold Therapy conditions: Pain, Postoperative studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This study was planned as a prospective, parallel, two-arm (1:1) randomized controlled trial (RCT). primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 78 type: ESTIMATED name: cold therapy measure: pain level measure: edema measure: amount of drainage measure: Analgesic consumption sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Karamanoğlu Mehmet bey Üniversitesi status: RECRUITING city: Merkez state: Karaman zip: 70100 country: Turkey name: fatma gök role: CONTACT phone: 05544906142 email: fatmagok123@gmail.com hasResults: False
nctId: NCT06262009 id: APHP220101 id: 2023-A02282-43 type: OTHER domain: IDRCB briefTitle: Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment acronym: Dyaspeo overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2026-09 date: 2027-03 date: 2024-02-15 date: 2024-02-15 name: Assistance Publique - Hôpitaux de Paris class: OTHER briefSummary: Humans in contact with animals such as dog owners, may be at risk of antimicrobial resistance (AMR) acquisition. This is the central issue to be investigated in DYASPEO conditions: Antibiotic Resistant Strain conditions: Transmission, Close-Contact studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 525 type: ESTIMATED name: human faecal collection name: ancillary study measure: generation of a list of priorities for future prevention and control strategies to mitigate antimicrobial resistance (AMR) transmission between companion animals and humans measure: Rates of AMR acquisitions in one or several housekeepers measure: A list in nature of changes in dog microbiota measure: A list in magnitude of changes in dog microbiota measure: A list in nature of changes in housekeepers microbiota measure: A list in magnitude of changes in housekeepers microbiota measure: explore unknown parameters of AMR colonization in dogs under various antibiotic exposures measure: the generation of a list of sociological factors and potential at-risk practices relevant in the transmission of AMR from dogs to housekeepers sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: the National Veterinary School Alfort city: Maisons-Alfort zip: 94700 country: France name: Jean-Yves Madec, PHD role: CONTACT phone: 06 85 08 93 30 phoneExt: +33 email: jean-yves.madec@anses.fr lat: 48.81171 lon: 2.43945 hasResults: False
nctId: NCT06261996 id: henanFSH briefTitle: Safety and Efficacy of Fospropofol vs Propofol During Invasive Mechanical Ventilation. overallStatus: NOT_YET_RECRUITING date: 2024-02-12 date: 2025-01-15 date: 2025-01-15 date: 2024-02-15 date: 2024-02-15 name: Henan Provincial People's Hospital class: OTHER briefSummary: The goal of this clinical trial is to compare the safety and efficacy of fospropofol and propofol during sedation in invasively mechanically ventilated patients in the Anesthesia Intensive Care Unit (AICU). Specific objectives include the following:
Participants will be sedated with fospropofol or propofol during invasive mechanical ventilation. conditions: Invasive Mechanical Ventilation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 200 type: ESTIMATED name: Fospropofol measure: The patient's Richmond Agitation-Sedation Scale (RASS) score and the incidence of adverse reactions measure: Incidence of adverse reactions during the follow-up period measure: Extubation time sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06261983 id: 2019111032 briefTitle: Magnetic Localization of Sentinel Nodes in Squamous Cell Oral Carcinoma. acronym: SentiMag overallStatus: RECRUITING date: 2018-10-01 date: 2024-12-31 date: 2024-12-31 date: 2024-02-15 date: 2024-02-15 name: Hospital Donostia class: OTHER briefSummary: Sentinel node biopsy has been shown to be a viable alternative to elective neck dissection in the early stages of squamous cell oral carcinoma. The aim of this study was to describe the magnetic localization of sentinel nodes (SN) after peritumoral injection of superparamagnetic iron oxide (SPIO) for treating this type of tumor and to analyze the technique's diagnostic performance in 23 patients. The technique located SNs (with minimal complication) in 95.6 % (22/23) of the patients. Three relapses occurred, one in a patient who had shown negative in magnetic SN location and elective neck dissection. The diagnostic performance of magnetic localization achieved a sensitivity and negative predictive value of 0.80 y 0.94, respectively. Magnetic localization of SNs has been shown to be a reproducible technique that may offer a viable alternative to the conventional technique. conditions: Diagnostic Value of Sentinel Node Biopsy Guided by Magnetic Probe studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 24 type: ESTIMATED name: Sentinel node biopsy guided by magnetic probe measure: The diagnostic performance of SNB was analyzed in terms of sensitivity (S), specificity (Sp), negative and positive predictive value (NPV and PPV). sex: ALL minimumAge: 29 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Josué Hernando Vázquez status: RECRUITING city: Donostia state: Guipuzkoa zip: 20011 country: Spain name: Josué Hernando, PhD, DDS role: CONTACT phone: 0034 675825482 email: josue.hernando@gmail.com lat: 43.31283 lon: -1.97499 hasResults: False