hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06366386 id: 5K43TW011963-03 type: NIH link: https://reporter.nih.gov/quickSearch/5K43TW011963-03 briefTitle: Integrating Hypertension Management in DSD for HIV acronym: HTN-DSD overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-30 date: 2026-05-30 date: 2024-04-15 date: 2024-04-18 name: Infectious Diseases Research Collaboration, Uganda class: OTHER briefSummary: The goal of this implementation science study is to design evidence based and stakeholder informed implementation strategies to integrate the management of hypertension (HTN) into existing community anti-retro-viral treatment (ART) delivery models of HIV care in Uganda and evaluate their effectiveness and implementation outcomes. The main questions it aims to answer are:
6. What is the cumulative incidence, types and severity of HTN medication-related adverse events and their predictors among PLHIV with HTN? Investigators will use qualitative research methods to explore key stakeholders' perspectives and preferences on integrating hypertension care in community ART delivery models in Uganda; design implementation strategies that integrate the management of hypertension into existing community ART delivery models; determine the effectiveness of implementation strategies that integrate the management of hypertension in community ART delivery models; evaluate implementation outcomes of strategies that integrate hypertension care in community ART delivery models; determine the cumulative incidence, types and severity of medication-related adverse events and their predictors; and assess the patients and provider costs, health related quality of life, cost-effectiveness of leveraging existing HIV differentiated service delivery models to screen and treat HTN among persons with HIV in Uganda. conditions: Hypertension conditions: HIV studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1100 type: ESTIMATED name: Screening and treatment of hypertension among PLHIV in DSD models for HIV measure: Number of PLHIV with controlled blood pressure (both systolic and diastolic blood pressure) measure: % of PLHIV with controlled blood pressure (both systolic and diastolic blood pressure) measure: Mean blood pressure (both systolic and diastolic blood pressure) measure: Number and % of hypertensive PLHIV with suppressed Viral load measure: Number and % of patients retained in care measure: Number and % of PLHIV screened for HTN at least once in six months measure: Implementation costs sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Infectious Diseases Research Collaborations (IDRCUganda) city: Kampala state: Central zip: +256 country: Uganda name: Martin Muddu, MMED role: CONTACT phone: +256774004308 email: muddu.martin@gmail.com lat: 0.31628 lon: 32.58219 hasResults: False
nctId: NCT06366373 id: 531118232022 briefTitle: An Evaluation on a Mental Health Art Exhibition's Impact on Reducing Stigma overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-02 date: 2025-02 date: 2024-04-15 date: 2024-04-15 name: Hunan University class: OTHER name: Central South University briefSummary: Mental health art exhibitions, as an intervention strategy integrating artistic expression and social contact, have the potential to positively impact the elimination of stigma and discrimination associated with mental health problems. This study will utilize a real-world quasi-randomized controlled trial design and a 6-month follow-up questionnaire survey to evaluate the intervention's impact on stigma/discrimination and related outcomes, such as mental health literacy. The evaluation will encompass four categories of people: those with lived experience of mental disorders, family members and friends of those with lived experience, health professionals, and the general public. Additionally, the cost-effectiveness of the art exhibition intervention will be analyzed. conditions: Mental Health Issue studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The interventional study model for this clinical trial is a quasi-randomized controlled trial design. The intervention is the exhibition, organized by "Qixi Charity," will publicly display offline artworks reflecting the diverse dimensions of mental health and ill-health. In contrast, the control group in this study will receive either printed or online educational materials, serving as a more traditional educational intervention. The study will include a baseline survey before the interventions (T0), a follow-up survey in the first month after the interventions (T1), and a follow-up survey in the sixth month after the interventions (T2) in both the experimental group (those who attend the offline exhibition) and the control group (those who are unable to attend the exhibition but will be provided with printed/online education materials). primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 1200 type: ESTIMATED name: A mental health art exhibition name: printed or online education materials measure: Stigma/discrimination regarding mental disorders measure: mental health literacy measure: intervention costs sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06366360 id: Piano-Neglect briefTitle: Immersive Virtual Reality Treatment for Unilateral Spatial Neglect overallStatus: RECRUITING date: 2024-03-11 date: 2026-09 date: 2027-09 date: 2024-04-15 date: 2024-04-16 name: Hopitaux de Saint-Maurice class: OTHER briefSummary: Unilateral Spatial Neglect (USN) is a relatively common neuropsychological syndrome following stroke. It is characterized by difficulties in detecting, orienting and identifying events located in the hemispace contralateral to a brain lesion, unrelated to a primary motor or sensory disorder. Numerous methods have been developed for the rehabilitation of this syndrome. However, limitations in terms of efficacy are highlighted. These limitations may be linked to the fact that these methods are restricted to certain sensory modalities, thus failing to take into account the heterogeneity of the syndrome. Moreover, some patients' adherence to rehabilitation programs can also be complicated by motivational difficulties. Immersive Virtual Reality could help overcome these limitations. Indeed, it enables the introduction of new sensory modalities, notably auditory, to support a better apprehension of space.
To achieve these goals, patients will benefit from immersive virtual reality rehabilitation based on music practice. This rehabilitation will be compared to conventional USN rehabilitation. To this end, patients will be divided into two groups: classical rehabilitation only or classical rehabilitation and immersive virtual reality in parallel. Each patient will be randomly assigned to one of the two groups for a period of 2 weeks. Pre- and post-rehabilitation assessments will be provided. conditions: Stroke conditions: Unilateral Spatial Neglect studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Each patient was assigned to a group that received 2 rehabilitations for 4 weeks, 1) both Immersive virtual reality therapy and a conventional rehabilitation first, and then conventional rehabilitation alone, or 2) A conventional rehabilitation alone and then both Immersive virtual reality therapy, and conventional rehabilitation. primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Immersive Virtual Reality Intervention name: Conventional rehabilitation measure: Bells Test measure: Mesulam cancellation Task measure: Bisection Test measure: Copying Test measure: Scene description Task measure: Ecological scale of daily life activities measure: Piano bisection Task measure: Identifying the keys at the ends of the piano measure: Virtual reality Bells Test measure: Auditory Stimuli Localization Task in virtual reality measure: Ecological virtual reality bisection task measure: Virtual reality Baking Tray test measure: Mood assessment measure: Situational motivation questionnaire sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hôpitaux de Saint-Maurice status: RECRUITING city: Saint-Maurice zip: 94410 country: France name: Secretary role: CONTACT phone: 01 43 96 68 22 phoneExt: +33 email: secretariat.ssrneuro@ght94n.fr lat: 48.82182 lon: 2.42716 hasResults: False
nctId: NCT06366347 id: 23-695 briefTitle: ALPINE: Maintenance Letrozole/Abemaciclib vs Pembrolizumab overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2027-09-01 date: 2029-03-01 date: 2024-04-15 date: 2024-04-23 name: Dana-Farber Cancer Institute class: OTHER name: Eli Lilly and Company briefSummary: A standard treatment for endometrial cancer is chemotherapy and pembrolizumab together followed by pembrolizumab maintenance for two years. This treatment regimen has shown benefit in terms of delaying cancer progression in prior clinical trials, but the benefit of the pembrolizumab maintenance treatment and whether all participants need it is unclear. This research is being done on the maintenance portion of treatment to compare the efficacy between the combination of letrozole + abemaciclib and pembrolizumab alone following chemotherapy and pembrolizumab.
* Pembrolizumab (a type of monoclonal antibody) conditions: Endometrial Cancer conditions: Recurrent Endometrial Cancer conditions: TP53 studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 76 type: ESTIMATED name: Abemaciclib name: Letrozole name: Pembrolizumab measure: Median Progression Free Survival (PFS) measure: Grade 3-5 Adverse Events (AE) Rate measure: Median Overall Survival (OS) measure: Objective Response Rate (ORR) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beth Israel Deaconess Medical Center city: Boston state: Massachusetts zip: 02215 country: United States name: Meghan Shea, MD role: CONTACT phone: 617-667-3723 email: mshea4@bidmc.harvard.edu name: Meghan Shea, MD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Brigham and Women's Hospital city: Boston state: Massachusetts zip: 02215 country: United States name: Panagiotis Konstantinopoulos, MD, PhD role: CONTACT phone: 617-632-2334 email: Panagiotis_Konstantinopoulos@dfci.harvard.edu name: Panagiotis Konstantinopoulos, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Dana-Farber Cancer Institute city: Boston state: Massachusetts zip: 02215 country: United States name: Panagiotis Konstantinopoulos, MD, PhD role: CONTACT phone: 617-632-2334 email: Panagiotis_Konstantinopoulos@dfci.harvard.edu name: Panagiotis Konstantinopoulos, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Dana-Farber Cancer Institute at Foxborough city: Foxboro state: Massachusetts zip: 02035 country: United States name: Natalie Sinclair, MD role: CONTACT phone: 508-543-1700 email: natalie_sinclair@dfci.harvard.edu name: Natalie Sinclair, MD role: PRINCIPAL_INVESTIGATOR lat: 42.06538 lon: -71.24783 facility: Dana-Farber Cancer Institute at Milford city: Milford state: Massachusetts zip: 01757 country: United States name: Alexandra Bailey, MD role: CONTACT phone: 508-488-3700 email: alexandras_bailey@dfci.harvard.edu name: Alexandra Bailey, MD role: PRINCIPAL_INVESTIGATOR lat: 42.13982 lon: -71.51617 facility: Dana-Farber Cancer Institute at South Shore Hospital city: Weymouth state: Massachusetts zip: 02190 country: United States name: Meredith Faggen, MD role: CONTACT phone: 781-624-4800 email: meredith_faggen@dfci.harvard.edu name: Meredith Faggen, MD role: PRINCIPAL_INVESTIGATOR lat: 42.22093 lon: -70.93977 hasResults: False
nctId: NCT06366334 id: 23/02E briefTitle: Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal Ideation acronym: KSI overallStatus: RECRUITING date: 2024-01-15 date: 2024-08-30 date: 2024-09-30 date: 2024-04-15 date: 2024-04-15 name: Children's Hospital of Eastern Ontario class: OTHER briefSummary: Approximately 20% of Canadian adolescents experience thoughts of suicide, or suicidal ideation (SI), and suicide is the second leading cause of death among Canadians aged 15-19 years. The emergency department at CHEO sees approximately four patients per day with SI. Even though this is a medical emergency, there are no fast-acting treatments available.
If intravenous ketamine can relieve symptoms of SI for youth, this would have tremendous effects on patients and would dramatically change how physicians treat adolescent mental health emergencies. If ketamine is effective for several weeks, as it is in adults, it will help temporize patients until they receive more long-term psychiatric care. At the system level, it has the potential to reduce emergency visits and lengthy admissions. The investigators feel that the results of this study will be generalizable to pediatric centres across Canada and beyond. conditions: Suicidal Ideation conditions: Suicidal Ideas studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: Ketamine Hydrochloride name: Normal saline measure: Proportion of eligible participants who complete the study protocol measure: Baseline distribution of responses to the first 5 questions of Beck Scale for Suicidal Ideation (SSI5) measure: Baseline distribution of responses to the suicide item (#10) from the Montgomery-Asberg Depression Rating Scale (MADRS10) measure: Baseline distribution of responses to the suicide item (#9) from the Beck Depression Index (BDI9). measure: Baseline pragmatic assessment of the first 5 questions of the Beck Scale for Suicidal Ideation (SSI5), the suicide item (#10) from the Montgomery-Asberg Depression Rating Scale (MADRS10), and the suicide item (#9) from the Beck Depression Index (BDI9). measure: Assessment of blinding measure: Treatment efficacy measured by the Beck Scale for Suicidal Ideation (SSI5) measure: Treatment efficacy measured by the suicide item (#10) from the Montgomery-Asberg Depression Rating Scale (MADRS10) measure: Treatment efficacy measured by the suicide item (#9) from the Beck Depression Index (BDI9) measure: Treatment durability measured by the Beck Scale for Suicidal Ideation (SSI5) measure: Treatment durability measured by the suicide item (#10) from the Montgomery-Asberg Depression Rating Scale (MADRS10) measure: Treatment efficacy measured by the suicide item (#9) from the Beck Depression Index (BDI9) measure: Admission to Hospital measure: Length of Stay in Hospital measure: ED revisits measure: Safety Outcome 1: Clinically significant tachycardia measure: Safety Outcome 2: Clinically significant hypertension measure: Safety Outcome 3: Vomiting measure: Safety Outcome 4: Dissociation measure: Safety Outcome 5: Death sex: ALL minimumAge: 12 Years maximumAge: 17 Years stdAges: CHILD facility: Children's Hospital Of Eastern Ontario status: RECRUITING city: Ottawa state: Ontario zip: K1H 8L1 country: Canada name: Maala Bhatt, MD, MSc. role: CONTACT phone: 6137377600 phoneExt: 4178 email: mbhatt@cheo.on.ca name: Tyrus Crawford role: CONTACT phone: 6137377600 phoneExt: 4178 email: tcrawford@cheo.on.ca lat: 45.41117 lon: -75.69812 hasResults: False
nctId: NCT06366321 id: 23-067 briefTitle: Using Digital Technology Versus Conventional Relining Procedure for Correction of Loose Maxillary Complete Denture overallStatus: COMPLETED date: 2024-01-01 date: 2024-01-23 date: 2024-02-01 date: 2024-04-15 date: 2024-04-16 name: British University In Egypt class: OTHER briefSummary: This study aimed to evaluate the use of computer added designning / computer added manufacturing (CAD/ CAM ) technology versus conventional relining procedure for treating ill-fitted loose maxillary complete denture and its effect on patient satisfaction, denture retention, and denture adaptation to oral tissues. conditions: Dental Diseases conditions: Dental Trauma conditions: Bone Remodeling Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 12 type: ACTUAL name: relining technique name: CAD/CAM milling technique measure: patient satisfaction using questionnaire measure: denture retention measure: denture adaptation to oral tissues sex: ALL minimumAge: 50 Years stdAges: ADULT stdAges: OLDER_ADULT facility: British University in Egypt city: El Shorouk state: Cairo zip: 4914085 country: Egypt lat: 30.13806 lon: 31.61556 hasResults: False
nctId: NCT06366308 id: ProBiox briefTitle: Decade-Long Insights Into Transperineal Prostate Biopsy in a West China Population overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-05-01 date: 2024-06-01 date: 2024-04-15 date: 2024-04-16 name: West China Hospital class: OTHER briefSummary: Prostate cancer (PCa) remains one of the most prevalent malignancies affecting men globally. The disease spectrum of PCa ranges from indolent tumors, which may require minimal to no intervention, to aggressive, potentially lethal forms. The complexity of PCa underscores the critical need for precise diagnostics, as early and accurate detection is key to improving patient outcomes and tailoring appropriate treatment strategies. There have been remarkable advancements in biopsy technology. Significant strides in magnetic resonance imaging (MRI), especially with the establishment of the Prostate Imaging Reporting and Data System (PI-RADS), have substantially improved the accuracy of PCa detection. The combination of MRI with traditional biopsy methods, including MRI-targeted biopsy (MRI-TBx) and systematic biopsy (SBx), also marks a major advancement in the field.
Despite advances in PCa detection, the need for improving diagnostics and in-depth assessment of the latest PBx techniques through extensive, longitudinal studies remains critical. Besides, based on the world health organization (WHO) classification, PCa includes a range of pathological forms beyond the commonly known acinar adenocarcinoma. However, the prevalence and demographic distribution of non-adenocarcinoma types, as well as the characteristics of patients with these rarer forms, remain unclear. Leveraging PBx records spanning over 10 years and involving 10,038 cases, this study aims to shed light on temporal trends in PBx positivity, the evolving clinical profiles of PCa patients, and the differences in clinicopathological characteristics of PCa between Western and Asian populations. conditions: Prostate Cancer conditions: Pathology studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 10000 type: ESTIMATED name: Transperineal Prostate Biopsy measure: Positive rate of prostate biopsy sex: MALE minimumAge: 40 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06366295 id: WUM.Perio.05 briefTitle: Comparison of Subgingival Mechanotherapy With and Without the Use of a Perioscope: Clinical Trial overallStatus: RECRUITING date: 2023-06-01 date: 2024-04 date: 2024-11 date: 2024-04-15 date: 2024-04-17 name: Medical University of Warsaw class: OTHER briefSummary: The study aims to comparatively assess clinical parameters, biochemical and microbiological parameters after treatment of periodontitis using subgingival mechanotherapy traditional and subgingival mechanotherapy using a perioscope. conditions: Periodontitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 26 type: ESTIMATED name: subgingival mechanotherapy with perioscopy name: classical subgingival mechanotherapy measure: Probing pocket depth (PPD) measure: Clinical attachment level (CAL) measure: Bleeding on probing (BoP) measure: Plaque index (PI) measure: Width of keratinized tissue (KTW) measure: Gingival thickness (GT) measure: Subgingival plaque pathogens (Aa, Pg, Td) levels measure: Gingival crevicular fluid levels of cytokines sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Department of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw status: RECRUITING city: Warsaw state: Mazowieckie zip: 02-097 country: Poland name: Bartlomiej Gorski, DDS, PhD role: CONTACT phone: +48 22 502 20 99 email: bartlomiej.gorski@wum.edu.pl lat: 52.22977 lon: 21.01178 hasResults: False
nctId: NCT06366282 id: IRB00110030 briefTitle: Pediatric and Caregiver Traumatic Stress Intervention (PACTS) acronym: PACTS overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-03 date: 2025-03 date: 2024-04-15 date: 2024-04-26 name: Wake Forest University Health Sciences class: OTHER name: Childress Institute for Pediatric Trauma briefSummary: The purpose of this study is to learn more about how to help the caregiver and child survivor of a traumatic injury handle post-traumatic stress disorder and/or depression. conditions: Traumatic Injury studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 24 type: ESTIMATED name: Caregiver Counseling for Childhood Traumatic Injury name: Standard of Care for Childhood Traumatic Injury measure: Change in Kessler 6 Scores measure: Change in Patient Health Questionnaire - 9 (PHQ-9) Scores measure: Change in Child and Adolescent Trauma Screen (CATS) Scores sex: ALL minimumAge: 1 Year maximumAge: 6 Years stdAges: CHILD facility: Wake Forest University Health Sciences city: Winston-Salem state: North Carolina zip: 27157 country: United States name: Elizabeth White, MA, LCMHCS role: CONTACT phone: 336-716-2801 email: ebwhite@wakehealth.edu name: Elizabeth Shilling, PhD role: PRINCIPAL_INVESTIGATOR lat: 36.09986 lon: -80.24422 hasResults: False
nctId: NCT06366269 id: STUDY20240374 briefTitle: Acupuncture First for IC/BPS overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-06 date: 2026-06 date: 2024-04-15 date: 2024-04-17 name: David Sheyn class: OTHER briefSummary: The goal of this clinical trial is to learn if acupuncture in addition to behavioral changes can better treat in women with bladder pain syndrome (also known as interstitial cystitis) that have not received other treatments. The main question it aims to answer is:
* attend six (6) weekly physical therapy sessions after finishing acupuncture conditions: Bladder Pain Syndrome conditions: Interstitial Cystitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Group allocation will be masked to the care provider and investigators only while participants undergo the initial 6 weeks of treatment. Due to the nature of the intervention (acupuncture) participants are not able to be blinded. whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 34 type: ESTIMATED name: Acupuncture name: Behavioral management name: Physical therapy measure: O'Leary-Sant Interstitial Cystitis Index (OLSICI) measure: Patient Global Impression of Improvement (PGI-I) measure: Short Form (SF-36) measure: Genitourinary Pain Index (GUPI) measure: Number of additional treatments used during study period measure: Number of unscheduled interactions sex: ALL minimumAge: 18 Years maximumAge: 89 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False