This 5-year study will commence in January 2024, with participant recruitment starting in March 2024 and finishing in May 2027. conditions: Sedentary Behavior conditions: Metabolic Syndrome conditions: Age-related Cognitive Decline conditions: Age-Related Sarcopenia studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Non-randomised, parallel design lifestyle intervention primaryPurpose: BASIC_SCIENCE masking: SINGLE maskingDescription: Those undertaking analysis of biological samples and MRI data will be masked as to the group the participant is allocated to. whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: Decreased Physical Activity name: Increased Physical activity measure: Change in Cardiorespiratory fitness (VO2 max) measure: Change in Isometric leg strength measure: Change in time to leg fatigue measure: Change in incremental area under the curve (iAUC) for blood glucose concentration measure: Change in iAUC for serum insulin concentration measure: Change in fasting glucose oxidation rate measure: Change in 'fed' glucose oxidation rate measure: Change in Short Form Health Survey (SF36) Questionnaire aggregated normalised 'physical' score measure: Change in Short Form Health Survey (SF36) Questionnaire aggregated and normalised 'mental' score measure: Change in World Health Organisation Quality of Life (WHOQoL) score measure: Change in Pittsburgh Sleep Quality Index (PSQI) measure: Change in Stroop test; % Accuracy measure: Change in Stroop test; reaction time measure: Change in four-choice reaction time test; % Accuracy measure: Change in four-choice reaction time test; reaction time measure: Change in card sort test; % Accuracy measure: Change in card sort test; reaction time measure: Change in Logical reasoning test; % accuracy measure: Change in Logical reasoning test; reaction time measure: Change in serial subtractions test; number of responses in 2 minutes measure: Change in Corsi blocks test; score measure: Change in Muscle protein synthesis rate measure: Change in Muscle protein breakdown rate measure: Change in whole body fat volumes measure: Change in liver fat volumes measure: Change in thigh muscle fat volumes measure: Change in whole body muscle volumes measure: Change in muscle phosphocreatine synthesis rate measure: Change in cerebral volume measure: Change in cortical thickness measure: Change in plasma metabolome measure: Fasting blood lipid concentration measure: Fasting blood lipid concentration measure: Fasting blood lipid concentration measure: Fasting blood lipid concentration measure: Fasting blood lipid concentration measure: liver function test: alanine transaminase (ALT) measure: liver function test: alanine transaminase (ALT) measure: liver function test: alanine transaminase (ALT) measure: liver function test: alanine transaminase (ALT) measure: liver function test: alanine transaminase (ALT) measure: liver function test: aspartate aminotransferase (AST) measure: liver function test: aspartate aminotransferase (AST) measure: liver function test: aspartate aminotransferase (AST) measure: liver function test: aspartate aminotransferase (AST) measure: liver function test: aspartate aminotransferase (AST) measure: liver function test: Bilirubin measure: liver function test: Bilirubin measure: liver function test: Bilirubin measure: liver function test: Bilirubin measure: liver function test: Bilirubin measure: liver function test: Albumin measure: liver function test: Albumin measure: liver function test: Albumin measure: liver function test: Albumin measure: liver function test: Albumin measure: liver function test: Gamma glutamyl transferase (GGT) measure: liver function test: Gamma glutamyl transferase (GGT) measure: liver function test: Gamma glutamyl transferase (GGT) measure: liver function test: Gamma glutamyl transferase (GGT) measure: liver function test: Gamma glutamyl transferase (GGT) measure: Blood Haemoglobin concentration measure: Blood Haemoglobin concentration measure: Blood Haemoglobin concentration measure: Blood Haemoglobin concentration measure: Blood Haemoglobin concentration sex: ALL minimumAge: 55 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: David Greenfield Human Physiology Unit status: RECRUITING city: Nottingham state: Notts zip: NG72UH country: United Kingdom name: Sara Brown role: CONTACT phone: +44(0)115 8230434 email: sara.brown@nottingham.ac.uk name: Joanne Mallinson, PhD role: CONTACT phone: +44(0)1158230434 email: joanne.mallinson@nottingham.ac.uk name: Paul Greenhaff, PhD role: PRINCIPAL_INVESTIGATOR name: Liz Simpson, PhD role: SUB_INVESTIGATOR name: Joanne Mallinson, PhD role: SUB_INVESTIGATOR name: Abhishek Sheth, MD role: SUB_INVESTIGATOR name: Penny Gowland, PhD role: SUB_INVESTIGATOR name: Sue Francis, PhD role: SUB_INVESTIGATOR name: Rosemary Nicholls, PhD role: SUB_INVESTIGATOR name: Aline Nixon role: SUB_INVESTIGATOR name: Sara Brown role: SUB_INVESTIGATOR name: Donald Peden, PhD role: SUB_INVESTIGATOR lat: 52.9536 lon: -1.15047 hasResults: False