nctId: NCT06273748 id: RChildUV briefTitle: RChildUV:Study on Non-infectious Chronic Uveitis in Pediatric Age overallStatus: RECRUITING date: 2022-02-10 date: 2032-02-01 date: 2032-05-02 date: 2024-02-23 date: 2024-03-08 name: Meyer Children's Hospital IRCCS class: OTHER briefSummary: Uveitis is an inflammatory disease of the uvea, one of the highly vascularized fundamental structures of the eye. It is a rare condition in children, with an incidence in the pediatric population ranging from 2% to 14% of all uveitis cases. The diagnosis and management of patients with uveitis rely on a multidisciplinary approach involving an ophthalmologist, a rheumatologist, and an infectious disease specialist to establish the correct diagnosis and assess the involvement of other organs. In Italy, there is no national or regional registry for non-infectious chronic uveitis as per the Prime Ministerial Decree (DPCM) of March 3, 2017 (Identification of surveillance systems and registries for mortality, tumors, and other diseases). However, many clinical centers adopt data recording systems to evaluate the quality of care and to study diseases and outcomes. The Universitary Hospital Meyer Institute Research Hospital (IRCCS) is a national referral center for managing these pediatric cases of non-infectious chronic uveitis, estimated to constitute 95% of all pediatric uveitis cases conditions: Uveitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 290 type: ESTIMATED measure: Describe a population of paediatric patients with chronic non-infectious uveitis measure: Describe a population of paediatric patients with chronic non-infectious uveitis measure: Identify any differences between the different forms of uveitis in terms of characteristics and outcomes measure: Identify risk factors for a more severe course measure: Frequency achievement of response for each drug according to the definition of response measure: Time to archieve the response after drug initiation measure: Achievement of inactive disease on therapy according to the definition of MIWGUC measure: Time to achieve inactive disease on therapy according to the definition of MIWGUC measure: Presence and percentages of flares on therapy after achievement of remission on therapy measure: Time to the first flare on therapy measure: Time to flare after drug withdrawal sex: ALL minimumAge: 1 Year maximumAge: 16 Years stdAges: CHILD facility: Cincinnati Children's Hospital Medical Center status: RECRUITING city: Cincinnati state: Ohio zip: 45207 country: United States name: Sheila Angels-Han role: CONTACT lat: 39.12713 lon: -84.51435 facility: - ATTIKON General Hospital status: RECRUITING city: Athens zip: 12462 country: Greece name: Lampros Fotis role: CONTACT lat: 37.97945 lon: 23.71622 facility: Meyer Children's Hospital IRCCS status: RECRUITING city: Florence state: Firenze country: Italy name: Gabriele Simonini role: CONTACT email: gabriele.simonini@meyer.it lat: 43.77925 lon: 11.24626 facility: Ospedale Spedali Civili di Brescia status: NOT_YET_RECRUITING city: Brescia country: Italy name: Marco Cattalini role: CONTACT lat: 45.53558 lon: 10.21472 facility: IRCCS materno infantile Burlo Garofolo status: RECRUITING city: Trieste country: Italy name: Serena Pastore role: CONTACT lat: 45.64953 lon: 13.77679 hasResults: False