hackint0sh/New-Dataset huggingface dataset:
In progressive renal disease, renal function decline correlates with the extent of interstitial fibrosis, irrespective of the original pathology. Experience and research in using shear-wave elastography to study the stiffness of renal parenchyma and renal fibrosis are scanty. The investigators will conduct a prospective observational study. This study aims to provide the information of tissue elasticity in different etiologies of renal diseases and to validate the predictive value of shear-wave elastography in predicting renal function and renal fibrosis.
By assuming a power of 0.8, a two-side p value of 0.05, a ratio of 0.2 (sample sizes in negative/positive groups) to detect the difference between area under ROC curve and null hypothesis value (0.8 and 0.7), a target sample of 273 (with a 5% cushion, 260\~290) patients is required. conditions: Kidney Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 500 type: ESTIMATED name: elastography measure: collect medical record of blood urea nitrogen and Creatinine sex: ALL minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Taiwan University Hospital status: RECRUITING city: Taipei country: Taiwan name: Fan-Chi Chang role: CONTACT phone: 886-0223123456 email: leiny.fc@gmail.com lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06363019 id: 2023/00158 briefTitle: Supporting At-Risk Mothers Across Perinatal Period acronym: SMART overallStatus: RECRUITING date: 2024-02-26 date: 2025-02-26 date: 2026-07-06 date: 2024-04-12 date: 2024-04-12 name: National University of Singapore class: OTHER name: Ministry of Health, Singapore briefSummary: The SMART app is a mobile application based psychosocial parenting intervention containing educational materials (articles, videos, audios, podcasts) on parenting, an integrated peer support chat function with experienced mothers and an integrated forum for interaction with other mother participants.
Researchers will compare results with a control group that will undergo standard routine care. conditions: Perinatal Depression conditions: Parents conditions: Anxiety conditions: Self Efficacy conditions: Stress conditions: Infant Development studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two-group parallel-armed randomized controlled trial with a pretest and repeated post-test experimental design primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 200 type: ESTIMATED name: Supporting at-risk Mothers Across perinatal period: a Randomized controlled Trial (SMART) mobile application measure: Postnatal depression measure: Infant physical development measure: Infant cognitive development measure: Infant emotional development measure: Anxiety measure: Perceived stress measure: Perceived social support measure: Maternal-infant bonding measure: Parental satisfaction measure: Parental efficacy measure: Objective stress measure: Emotional availability measure: Health services and utilization measure: Infant Physical Development measure: Infant Social Development measure: Infant Social Development measure: Infant Social Development measure: Infant Emotional Development sex: FEMALE minimumAge: 21 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Alice Lee Centre for Nursing Studies, National University of Singapore status: RECRUITING city: Singapore zip: 117597 country: Singapore name: Shefaly Shorey, PhD role: CONTACT phone: 66011294 phoneExt: +(65) email: nurssh@nus.edu.sg lat: 1.28967 lon: 103.85007 facility: National University of Singapore status: RECRUITING city: Singapore zip: 117597 country: Singapore name: Shefaly Shorey role: CONTACT phone: +6566011294 email: nurssh@nus.edu.sg lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06363006 id: K23C3280 briefTitle: Combination of Cardonizumab Injection and TKI Second Line Therapy for Advanced Hepatocellular Cancer overallStatus: RECRUITING date: 2024-03-11 date: 2026-01-01 date: 2027-01-01 date: 2024-04-12 date: 2024-04-12 name: Peking Union Medical College Hospital class: OTHER briefSummary: The goal of this clinical trial is to evaluate the efficacy and safety of cardonilizumab injection combined with TKI in second-line treatment of advanced hepatocellular carcinoma. The main questions it aims to answer are:
* Disease Control Rate (DCR); Duration of relief (DoR); Progression free survival (PFS); Total survival time (OS); Safety。 conditions: Hepatocellular Carcinoma studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: TKI+Cardunilimab measure: ORR Full single-arm, open, multicenter prospective clinical study measure: Progression-free Survival (PFS) measure: Disease Control Rate (DCR) measure: Overall Survival (OS) measure: Duration of Response (DOR) measure: Stable Disease (SD) measure: Progression free survival rate measure: Any adverse events related with treatment with TKI plus Cardonizumab. sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chinese Academy of Medical Sciences & Peking Union Medical College Hospital (CAMS&PUMCH) status: RECRUITING city: Beijing state: Beijing zip: 100730 country: China name: Haitao Zhao, Professor role: CONTACT phone: +861069156042 email: zhaoht@pumch.cn lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06362993 id: STUDY00021561 briefTitle: Breast Cancer Screening in Ghana overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-11 date: 2025-03 date: 2024-04-12 date: 2024-04-15 name: Penn State University class: OTHER name: University of Ghana briefSummary: This study is designed to test the feasibility of two intervention on promoting early screening for breast cancer in rural Ghana. In one intervention, screening for breast cancer, diabetes and hypertension will be offered together. In another intervention, a series of sessions with men will be conducted with a goal to change gender attitudes and increase support to women. The investigators' long-term goal is to test these interventions in a large-scale randomized controlled trial. The specific aims of this feasibility study are to: 1) refine the study materials, including the curriculum for the sessions with men, by consulting with an expert advisory committee and a local committee, and 2) determine the feasibility of the two interventions in four clinic zones in Yilo-Krobo district in eastern Ghana (1 clinic in control, 1 clinic in the first intervention, and 2 in the second intervention). This trial registration is for the second specific aim. conditions: Breast Cancer Female studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 150 type: ESTIMATED name: Bundling name: MEGH measure: Clinical breast exam (CBE) utilization at the local clinic sex: FEMALE minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362980 id: BPI-1178-IIT01 briefTitle: A Study With BPI-1178 and Osimertinib in Advanced Non-small Cell Lung Cancer Patients With EGFR Mutations acronym: EGFR overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2026-04-01 date: 2024-04-12 date: 2024-04-12 name: National Cancer Center, China class: OTHER briefSummary: BPI-1178 is a novel, orally administered inhibitor of both cyclin-dependent kinase 4 (CDK4) and CDK6 kinase activity. This open-label investigator-initiated trial (IIT) phase I study was designed to evaluate the safety and efficacy of oral BPI-1178 in combination with osimertinib in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) and epidermal growth factor receptor (EGFR) Mutations. conditions: NSCLC studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: BPI-1178 name: Osimertinib measure: Number of patients with dose-limiting toxicity (DLT) measure: Objective Response Rate (ORR) measure: Disease Control Rate (DCR) measure: Duration of Response (DoR) measure: Progression-Free Survival (PFS) measure: Overall Survival (OS) measure: Intracranial ORR (iORR) measure: Intracranial DCR (iDCR) measure: Intracranial DoR (iDoR) measure: Intracranial Time to Progression (iTTP) measure: Intracranial PFS (iPFS) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362967 id: Anti-HLA antibody briefTitle: The Efficacy and Safety of Desensitation Regimen for Patients With High Titers of Anti-HLA Antibodies Prior to Allo-HSCT overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-31 date: 2026-06-30 date: 2024-04-12 date: 2024-04-12 name: Anhui Provincial Hospital class: OTHER_GOV briefSummary: Evaluation of the efficacy and safety of immunoadsorption or plasma exchange combined with rituximab and high-dose IVIG to reduce high titres of anti-HLA antibodies in patients prior to allogeneic haematopoietic stem cell transplantation conditions: High Titers of Anti-HLA Antibody (MFI ≥5000) studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Immunoadsorption or plasma exchange combined with rituximab, high-dose IVIG measure: Incidence of reduction of anti-HLA antibody MFI values to less than 5000 in subjects at the end of treatment measure: Incidence of primary graft failure measure: Incidence of TRM after allo-HSCT measure: Incidence of ineffective platelet transfusion after allo-HSCT measure: Cumulative incidence of neutrophil engraftment after allo-HSCT measure: Cumulative incidence of II-IV° acute GVHD measure: Cumulative incidence of relapse at 1 year post-transplant measure: Probability of overall survival post transplantation measure: Incidence of allergies and allergic reactions measure: Incidence of haemorrhagic events measure: Incidence of viral, bacterial and fungal infections measure: Incidence of hypocalcaemia sex: ALL minimumAge: 14 Years maximumAge: 60 Years stdAges: CHILD stdAges: ADULT facility: The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital) city: Hefei state: Anhui zip: 230036 country: China lat: 31.86389 lon: 117.28083 hasResults: False
nctId: NCT06362954 id: AnkaraMedipolU-FTR-SS-01 briefTitle: The Relationship Between Muscle Oxygenation and Spasticity in Hemiparetic Stroke Patients overallStatus: RECRUITING date: 2023-12-31 date: 2024-04-01 date: 2024-06-01 date: 2024-04-12 date: 2024-04-12 name: Ankara Medipol University class: OTHER name: Gazi University briefSummary: Conditions such as hemiparesis, sensory and motor impairment, perceptual impairment, cognitive impairment, aphasia, and dysphagia may be observed after stroke. Motor impairment after stroke may occur due to damage to any part of the brain related to motor control. There is much clinical evidence that damage to different parts of the sensorimotor cortex in humans affects other aspects of motor function. Loss of strength, spasticity, limb apraxia, loss of voluntary movements, Babinski sign, and motor neglect are typical motor deficits following a cortical lesion (upper motor neuron lesion). Post-stroke spasticity can be seen in 19% to 92% of stroke survivors. Post-stroke hemiparesis is a significant cause of morbidity and disability, along with abnormal muscle tone. It has also been recognized that post-stroke hemiparesis may occur without spasticity. Spasticity seen after stroke causes loss of movement control, painful spasms, abnormal posture, increased muscle tone, and a general decrease in muscle function, and may affect limb blood flow. Studies in the literature show that spasticity can affect limb blood flow.
This study aims to investigate the relationship between muscle oxygenation and spasticity in post-stroke hemiparetic patients based on the idea that oxygenation may be insufficient as a result of restriction of blood flow on the affected side due to spasticity in stroke patients. conditions: Stroke conditions: Hemiparesis;Poststroke/CVA conditions: Spasticity as Sequela of Stroke studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 18 type: ESTIMATED name: Assessment measure: Plantar Flexors Muscle Oxygenation measure: Spasticity measure: Motor Function measure: 6-Minute Walk Test measure: Stair Climbing Test measure: Adipose tissue thickness sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Gazi University, Faculty of Health, Department of Physiotherapy and Rehabilitation status: RECRUITING city: Ankara state: Çankaya country: Turkey name: Gökhan Yazıcı, Assos. Prof. role: CONTACT phone: +90 506 316 0572 email: gokhanyazici38@hotmail.com name: Gökhan Yazıcı, Assos. Prof. role: PRINCIPAL_INVESTIGATOR name: Taylan Altıparmak, Asst. Prof. role: SUB_INVESTIGATOR name: Çağla Çağatay role: SUB_INVESTIGATOR lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06362941 id: NW-HGN-01 briefTitle: Evaluation of an Oral Hair Supplement to Improve Hair Strength and Support Growth in Women and Men overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-02-01 date: 2025-03-30 date: 2024-04-12 date: 2024-04-18 name: Nutraceutical Wellness Inc. class: INDUSTRY briefSummary: A single-center, open-label, prospective study to demonstrate the efficacy of an oral supplement to improve the strength and support the growth of thinning hair in men and women with self-perceived hair thinning. conditions: Hair Thinning studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single Group Assignment 6-month, single-center, prospective interventional study primaryPurpose: TREATMENT masking: NONE count: 200 type: ESTIMATED name: Nutrafol Women's Hair Growth Supplemnt name: Nutrafol Women's Balance Hair Growth Supplement name: Nutrafol Women's Vegan Hair Growth Supplement name: Nutrafol Women's Postpartum Hair Growth Supplement name: Nutrafol Men's Hair Growth Supplement measure: Change in hair shaft diameter compared to baseline at Day 180. measure: Change in hair shaft diameter compared to baseline at Day 90. measure: Change in broken hairs recovered from the hair pull test compared to baseline at Day 180 measure: Change in broken hairs recovered from the hair pull test compared to baseline at Day 90 measure: Change in hair breakage during the hair pull test compared to baseline at Day 180 measure: Change in hair breakage during the hair pull test compared to baseline at Day 90 measure: Change in the number of hairs recovered from the hair pull test compared to baseline at Day 180 measure: Change in the number of hairs recovered from the hair pull test compared to baseline at Day 90 measure: Subject Self-Perceived Improvement in Hair Quality at Day 180 measure: Subject Self-Perceived Improvement in Hair Quality at Day 90 sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Dermatology Consulting Services city: High Point state: North Carolina zip: 27262 country: United States name: Zoe Draelos role: CONTACT phone: 336-841-2040 email: zdraelos@northstate.net lat: 35.95569 lon: -80.00532 hasResults: False
nctId: NCT06362928 id: CP-60005 briefTitle: Safety and Effectiveness of the Akura Thrombectomy System in the Treatment of Acute Pulmonary Embolism overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2025-06 date: 2025-08 date: 2024-04-12 date: 2024-04-12 name: Akura Medical class: INDUSTRY briefSummary: This study is a prospective, single-arm, non-randomized, interventional, multicenter feasibility study to evaluate the safety and effectiveness of percutaneous mechanical thrombectomy using the Akura Thrombectomy System in subjects with acute pulmonary embolism (PE). conditions: Pulmonary Embolism Acute studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 15 type: ESTIMATED name: ATC System measure: Effectiveness measure: Safety: Composite of Major Adverse Device-Related Events measure: Safety: Composite of Major Adverse Events sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362915 id: FMASUR66/2024 briefTitle: Analgesic Effect of Illiohypogastic & Ilioinguinal Nerve Block in TAVR - TF (Prospective Randomized Study) overallStatus: RECRUITING date: 2024-01-02 date: 2024-07-15 date: 2024-08-30 date: 2024-04-12 date: 2024-04-12 name: Ain Shams University class: OTHER briefSummary: The purpose of the study is to compare the effect of illiohypogastric and ilioinguinal nerve block with the local infiltration with lidocaine in patients undergoing TAVI conditions: Anesthesia, Local studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: * Group (A): will receive blind local infiltration in femoral region on the operation side by an experienced anesthesiologist using 20 ml lidocaine 1% (9).
* Group (B): will receive ultrasound-guided ilioinguinal/iliohypogastric nerve block using 20 ml Bupivicane 0.25% by an experienced anesthesiologist. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 52 type: ESTIMATED name: Lidocaine name: Bupivacain measure: Extra Demand of sedation measure: Patient and surgeon satisfaction sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: maha sadek El Derh status: RECRUITING city: Cairo state: Heliopolis zip: 11721 country: Egypt lat: 30.06263 lon: 31.24967 facility: Ain Shams University status: RECRUITING city: Cairo country: Egypt name: maha S elDerh, Ass.prof role: PRINCIPAL_INVESTIGATOR lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06362902 id: NOSES-VIII B briefTitle: Laparoscopic Right Hemicolectomy With Transrectal Specimen Extraction for Colon Cancer overallStatus: RECRUITING date: 2024-03-01 date: 2025-09-01 date: 2025-09-01 date: 2024-04-12 date: 2024-04-12 name: National Cancer Center, China class: OTHER briefSummary: The purpose of this study is to investigate the preliminary surgical outcomes of laparoscopic right hemicolectomy with transrectal specimen extraction. The hypothesis is that this type of natural orifice specimen extraction surgery (NOSES) could achieve good short-term and oncological outcomes for right colon cancer patients. conditions: Colon Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 37 type: ESTIMATED name: Laparoscopic right hemicolectomy with transrectal specimen extraction measure: The rate of postoperative complications measure: Operating time measure: Estimated blood loss measure: The time of first flatus measure: Postoperative hospitalization sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Cancer Center status: RECRUITING city: Beijing state: Beijing zip: 100000 country: China name: Haitao Zhou, M.D. role: CONTACT phone: +8613381167333 email: zhouhaitao01745@163.com name: Yueyang Zhang, M.D. role: CONTACT phone: +8613552910035 email: yyzhang0129@163.com lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06362889 id: HealMD-CBD-1 briefTitle: Evaluating Microneedling With CBD and Hempseed Oil for Acne Vulgaris Safety and Efficacy overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-10 date: 2024-11 date: 2024-04-12 date: 2024-04-12 name: Rejuva Medical Aesthetics class: OTHER name: HealMD, LLC briefSummary: This is a prospective, single center, open label study to assess the safety and effectiveness of microneedling with CBD and hempseed oil for the treatment of moderate to severe acne in adults 22-years of age or older.The objective of this exploratory study is to evaluate the safety and efficacy of HealMD's CBD with hempseed oil to reduce the appearance of moderate to severe facial acne. conditions: Acne Vulgaris (Disorder) studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Microneedling with CBD measure: Primary efficacy endpoints measure: Secondary efficacy endpoints sex: ALL minimumAge: 22 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Rejuva Medical Aesthetics city: Los Angeles state: California zip: 90025 country: United States name: LaRyel A Waldon, B.S. role: CONTACT phone: 424-644-2400 email: laryel@rejuvamedical.org name: Margaux Oldfield role: CONTACT phone: 4246442400 email: margaux@rejuvamedical.org lat: 34.05223 lon: -118.24368 hasResults: False
nctId: NCT06362876 id: BAlis briefTitle: The Effect of Breastfeeding Counseling Based on Motivational Interviewing overallStatus: ACTIVE_NOT_RECRUITING date: 2023-09-15 date: 2024-08-15 date: 2024-12-15 date: 2024-04-12 date: 2024-04-12 name: Mersin University class: OTHER briefSummary: This research was planned to determine the effect of breastfeeding counseling based on motivational interviewing method and standard breastfeeding counseling on breastfeeding self-efficacy and breastfeeding results in women who had a cesarean section. conditions: Breastfeeding Counseling Based on Motivational Interviewing studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 74 type: ESTIMATED name: Breastfeeding Counseling Based on Motivational Interviewing name: Standard Breastfeeding Consultancy measure: Level of breastfeeding self-efficacy measure: Level of breastfeeding self-efficacy measure: Level of breastfeeding self-efficacy measure: Level of breastfeeding self-efficacy measure: Level of breastfeeding self-efficacy measure: Breastfeeding Results Evaluation Form measure: Breastfeeding Results Evaluation Form measure: Breastfeeding Results Evaluation Form measure: Breastfeeding Results Evaluation Form sex: FEMALE minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Mersin University city: Mersin zip: 33180 country: Turkey lat: 36.79526 lon: 34.61792 hasResults: False