The primary efficacy endpoint of the study will be the change from baseline in total lean mass at 4 months (112 days). Subjects will continue enobosarm (or matching placebo) monotherapy treatment from Day 112 to Day 196 to assess the effect of enobosarm on total lean mass, total muscle mass, maintenance of weight loss, and rebound fat gain after discontinuation of GLP-1 receptor agonists. A safety follow-up visit will occur approximately 30 days after last dose of study drug. primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: Double Blind whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 90 type: ESTIMATED name: Enobosarm name: Semaglutide measure: The primary endpoint for the study is the percentage change from baseline in total lean body mass at 112 days. measure: The percent change from baseline in total fat mass sex: ALL minimumAge: 60 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pinnacle Trials city: Anniston state: Alabama zip: 36207 country: United States name: April Bolt role: CONTACT phone: 256-460-6379 email: Abolt@Pinnacletrials.com name: Almena Free role: PRINCIPAL_INVESTIGATOR lat: 33.65983 lon: -85.83163 facility: Cullman Clinical Trials city: Cullman state: Alabama zip: 35055 country: United States name: Cheryl Hargrove role: CONTACT phone: 256-708-2826 email: cheryl@cullmanclinicaltrials.com name: Randall Quinn role: PRINCIPAL_INVESTIGATOR lat: 34.17482 lon: -86.84361 facility: Velocity Clinical Research, CA city: Los Angeles state: California zip: 90057 country: United States name: Jenny Francisco role: CONTACT phone: 213-413-2500 email: JFrancisco@velocityclinical.com name: David Guzman role: PRINCIPAL_INVESTIGATOR lat: 34.05223 lon: -118.24368 facility: Artemis Institute for Clinical Research city: San Diego state: California zip: 92103 country: United States name: Analicia Murillo role: CONTACT phone: 858-867-3557 email: analicia.murillo@artemis-research.com name: Stacy Layle role: PRINCIPAL_INVESTIGATOR lat: 32.71533 lon: -117.15726 facility: Universal Axom Clinical Research city: Doral state: Florida zip: 33122 country: United States name: Diana Marinez role: CONTACT phone: 305-677-9267 phoneExt: 24 email: Dmarinez@uaclinical.com name: Luis Martinez role: PRINCIPAL_INVESTIGATOR lat: 25.81954 lon: -80.35533 facility: Altus Research city: Lake Worth state: Florida zip: 33461 country: United States name: Junieth Leyes role: CONTACT phone: 561-641-0404 email: jleyes@altusresearch.com name: Samuel Lederman role: PRINCIPAL_INVESTIGATOR lat: 26.61708 lon: -80.07231 facility: MARC Research Center city: Louisville state: Kentucky zip: 40213 country: United States name: Laken Heitz role: CONTACT phone: 502-214-3925 email: lheitz@lmarc.com name: Harold Bays role: PRINCIPAL_INVESTIGATOR lat: 38.25424 lon: -85.75941 facility: Pennington Biomedical city: Baton Rouge state: Louisiana zip: 70810 country: United States name: Aubrey Windham role: CONTACT phone: 225-763-2618 email: aubrey.windham@pbrc.edu name: Steven Heysmfield role: PRINCIPAL_INVESTIGATOR lat: 30.45075 lon: -91.15455 facility: DelRicht Research - New Orleans city: New Orleans state: Louisiana zip: 70115 country: United States name: Emily Krambeck role: CONTACT phone: 504-336-2667 email: ekrambeck@delricht.com name: Patrick Dennis role: PRINCIPAL_INVESTIGATOR lat: 29.95465 lon: -90.07507 facility: Centennial Medical Group (CMG) city: Elkridge state: Maryland zip: 21075 country: United States name: Tyler Stine role: CONTACT phone: 443-698-8678 email: TSTINE@centennialmedical.com name: Steven Geller role: PRINCIPAL_INVESTIGATOR lat: 39.21261 lon: -76.71358 facility: SKY Integrative Medical Center city: Ridgeland state: Mississippi zip: 39157 country: United States name: Bob Hutchins role: PRINCIPAL_INVESTIGATOR lat: 32.42848 lon: -90.13231 facility: Clinvest Headlands LLC city: Springfield state: Missouri zip: 65807 country: United States name: Kealon Cox role: CONTACT phone: 417-883-7889 email: kealon.cox@clinvest.com name: David True role: PRINCIPAL_INVESTIGATOR lat: 37.21533 lon: -93.29824 facility: Palm Research Center city: Las Vegas state: Nevada zip: 89119 country: United States name: Sasha Sandry role: CONTACT phone: 702-736-5161 email: sasha@palmresearchcenter.com name: Samer Nakhle role: PRINCIPAL_INVESTIGATOR lat: 36.17497 lon: -115.13722 facility: Lillestol Research LLC city: Fargo state: North Dakota zip: 58104 country: United States name: Michael Lillestol role: CONTACT phone: 701-232-7705 email: lillestolmd@lillestolresearch.com name: Michael Lillestol role: PRINCIPAL_INVESTIGATOR lat: 46.87719 lon: -96.7898 hasResults: False