hackint0sh/New-Dataset huggingface dataset:
* 30-day and one-year mortality after screening Participants will be evaluated for positive screening results with following multidrug resistant gram negative bacilli: ESBL producing Enterobacterales, Carbapenemase producing Enterobacterales, Carbapenem resistant P.aeruginosa and carbapenem resistant Acinetobacter baumannii. Researchers will compare patients with positive and negative screening results to see, if the relative risks in the two groups differ in admission rates and mortality. conditions: Multi-antibiotic Resistance studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 10000 type: ESTIMATED name: (exposure of) MDR carriage measure: The ratio of the probability of all-cause admission in patients who are screening positive to the probability of all-cause admission in patients who are screening negative. measure: The ratio of the probability of death in patients who are screening positive to the probability of death in patients who are screening negative. measure: The ratio of the probability of antibiotic use in patients who are screening positive to the probability of antibiotic use in patients who are screening negative. measure: prevalence of positive screening results measure: prevalence of MDR in clinical samples measure: time to first occurrence of phenotypically same MDR as in screening measure: prevalence of MDR in clinical samples in patients with negative screening results sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06370286 id: PACNL_rueihongli_CE_IC briefTitle: The Effect of Acute Concurrent Exercise on Inhibitory Control: An Event-related Potential Study overallStatus: COMPLETED date: 2021-02-15 date: 2021-08-15 date: 2022-02-15 date: 2024-04-17 date: 2024-04-18 name: National Taiwan Normal University class: OTHER briefSummary: The present study aimed to determine the effects of acute concurrent exercise on inhibitory control via behavioral and event-related potential approaches and to examine its potential mediational role on lactate among younger adults. The main questions it aims to answer are: (1) Does acute concurrent exercise improve inhibitory control via behavioral and event-related potential approaches? (2) Does lactate play a potential mediational role in the effect of acute concurrent exercise on inhibitory control? conditions: Exercise conditions: Cognition studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants were randomly assigned to either a concurrent exercise (CE), aerobic exercise (AE), or control (CON) group. Participants in the CE group engaged in 12-minutes of AE (40%-59% of heart rate reserve \[HRR\]) coupled with 13-minutes of resistance exercise (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). The AE group participated in 25 minutes of AE (40%-59% HRR). Prior to and following exercise onset, participants in both the CE and AE groups completed a 5-minute warm-up and cool-down. Participants in the CON group read books for 35 minutes. Lactate concentrations were measured at timepoint of 0-, 17-, and 30-minutes relative to the treatment onset. Response time (RT) and accuracy in the Stroop test, as well as P3 amplitudes, were assessed before and after the treatment. primaryPurpose: TREATMENT masking: NONE count: 78 type: ACTUAL name: concurrent exercise (CE) name: aerobic exercise (AE) measure: Inhibitory control measure: Blood lactate sex: ALL minimumAge: 20 Years maximumAge: 30 Years stdAges: ADULT facility: Department of Physical Education and Sport Sciences, National Taiwan Normal University city: Taipei zip: 106 country: Taiwan lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06370273 id: 1009305 briefTitle: Thromboprophylaxis in Lower Limb Immobilisation acronym: TiLLI overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2028-02 date: 2028-02 date: 2024-04-17 date: 2024-04-17 name: Queen Mary University of London class: OTHER briefSummary: The goal of this clinical trial is to find out the clinical and cost effectiveness of Thromboprophylaxis in participants who have been placed in a plaster cast or splint after injury.
Drug treatments will be provided for the duration of immobilisation or up to 42 days (whichever is earlier), in accordance with current NICE guidelines. The participants will be followed up for 90 days following randomisation. conditions: Thrombosis conditions: Injury Leg studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A pragmatic, open-label, linked pair of randomised controlled trials with common outcomes and parallel economic analysis each with internal pilot phases, conducted across 30 NHS sites primaryPurpose: PREVENTION masking: SINGLE maskingDescription: Open-label study. Trial Statistician and Health Economist to be blinded for analysis whoMasked: OUTCOMES_ASSESSOR count: 10044 type: ESTIMATED name: Rivaroxaban name: Apixaban name: Enoxaparin Injectable Solution name: Tinzaparin Injectable Solution name: Dalteparin Injectable Solution name: Fondaparinux Injectable Product measure: Composite of net clinical benefit comprising clinical VTE event, major bleeding, and cause-specific mortality measure: Symptomatic VTE event occurrence measure: Major bleeding occurrence measure: Cause-specific mortality occurrence measure: Adverse and Serious adverse events measure: Medication adherence measure: Health utility (EQ-5D-5L) measure: Patient satisfaction regarding the burdens and benefits of anticoagulation measure: Hospital readmission/reattendance measure: Health and social care resource use measure: Patient longer term outcome VTE and bleeding data sex: ALL minimumAge: 16 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06370260 id: INTM-PMCF-UNIGEL id: 571/13.02.2023 type: OTHER domain: INTERMED S.A briefTitle: Assessing the Efficacy of a Hydrogen Peroxide Gel for Oral Wound Healing and Oral Hygiene overallStatus: COMPLETED date: 2023-05-02 date: 2023-12-27 date: 2023-12-27 date: 2024-04-17 date: 2024-04-17 name: National and Kapodistrian University of Athens class: OTHER name: Ioulia And Irene Tseti Pharmaceutical Laboratories S.A. briefSummary: This study aims to assess the effectiveness and safety of a hydrogen carbamide/peroxide gel, called UNISEPT® ORAL GEL, in promoting oral wound healing, alleviating postoperative symptoms, and enhancing oral hygiene.
Oral wound healing, postoperative symptoms (such as pain, eating and speech difficulties), oral hygiene (dental plaque and gingival inflammation) and quality of life are assessed during a 14-day period after the biopsy. Participants are required to visit the clinic three times, one for the initial biopsy, one at 7 days and one at 14 days after the biopsy. They are asked to fill in some questionnaires, while certain procedures (taking a photo the site of the biopsy) and assessments (like evaluating the dental plaque and gingival inflammation) take place. During the first week they, also, keep a diary of their symptoms, as instructed. conditions: Wound Heal conditions: Postoperative Pain conditions: Biopsy Wound conditions: Wound; Mouth conditions: Quality of Life conditions: Dental Plaque conditions: Gingival Inflammation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This trial is designed as a prospective, randomized, placebo-controlled, triple blinded, with two parallel groups and an equal allocation ratio in all groups. In this study, the intervention consists of delivery of a hydrogen carbamide/peroxide gel or placebo gel, made by the same manufacturer. primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 54 type: ACTUAL name: Hydrogen Carbamide/Peroxide Gel name: Placebo Gel measure: Assessment of wound healing based on Percentage Healing Index on day 14 measure: Assessment of wound healing based on Percentage Healing Index on day 7 measure: Postoperative symptoms (pain, eating and speech difficulty) during the first week (at home) measure: Postoperative symptoms (pain, eating and speech difficulty) on day 7 measure: Postoperative symptoms (pain, eating and speech difficulty) on day 14 measure: Wound healing based on clinical signs measure: Oral Hygiene - Dental Plaque: Sextant Plaque Index measure: Oral Hygiene - Gingival Inflammation: Sextant Gingival Index measure: Oral Health Related Quality of Life measure: Adverse Events measure: Participant's comments and satisfaction regarding the provided treatment/use of the products measure: Compliance sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry city: Athens state: Attiki zip: 11527 country: Greece lat: 37.97945 lon: 23.71622 hasResults: False
nctId: NCT06370247 id: Soh-Med-23-04-07PD. briefTitle: First-time Usage of SGLT2 Inhibitors in Type 2 Diabetic Patients Who Are Fasting During Ramadan: Safety and Efficacy overallStatus: COMPLETED date: 2023-04-25 date: 2023-06-25 date: 2023-09-25 date: 2024-04-17 date: 2024-04-17 name: Sohag University class: OTHER briefSummary: All healthy Muslim adults are required to observe the Ramadan fast, which is one of Islam's five pillars. People with Type 2 Diabetes Mellitus frequently fast throughout Ramadan (T2DM).
Although fasting during Ramadan is said to have positive effects on diabetes patients, such as a reduction in excess body weight and an improvement in lipid profile it can be linked to a slight increased risk for metabolic complications that need immediate attention, such as hypoglycemia and hyperglycemia, dehydration, and diabetic ketoacidosis (DKA The number of diabetics worldwide was projected to reach 537 million in 2021. Studies have shown that there are a rising number of people in this category, and by 2045, there will be 738 million people worldwide who have diabetes. Almost 150 million Muslims worldwide have diabetes, and this number is progressively rising. Research estimates that 118 million of these Muslims who have diabetes fast throughout Ramadan, underscoring the need of choosing the best treatment strategy at this time. Almost two-thirds of all Muslims with T2DMfast throughout the month of Ramadan, according to studies from CREED, Epidemiology of Diabetes, and Ramadan.According to this, the most recent study showed that 86% of patients with T2DMreported a fast for at least 2 weeks.
Patient education, which should cover information on risks, lifestyle modifications, glucose monitoring, diet, exercise, and medication, is a crucial component of managing diabetes during Ramadan.Several studies have demonstrated the effectiveness and safety of sodium glucose cotransporter 2 inhibitors (SGLT2 I) in T2DM patients who are fasting throughout Ramadan. In individuals with T2DM, SGLT2 inhibitors have shown to reduce cardiovascular events and slow the course of renal disease.
In the literature published so far, SGLT2i has shown lower rates of hypoglycemia and hypovolemia during fasting as compared to sulphonylureas (SU). conditions: SGLT2 Inhibitors, First Time Use conditions: Type2 Diabetes conditions: Fasting in Ramadan studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 60 type: ACTUAL name: HbA1c, serum creatinine, eGFR urine analysis and serum electrolyte Na and K measure: blood glucose level monitoring measure: safety of SGLT2 inhibitors usage during ramadan sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Sohag Faculty of Medicine city: Sohag country: Egypt lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06370234 id: 201412166MINA briefTitle: The Prediction Model of NAC Response for Breast Cancer Based on The Parametric Dynamics Features. overallStatus: COMPLETED date: 2015-04-21 date: 2019-06-30 date: 2020-03-03 date: 2024-04-17 date: 2024-04-17 name: National Taiwan University Hospital class: OTHER name: Ministry of Science and Technology, Taiwan briefSummary: The main purpose of this study is to develop a computer-aided prediction model for NAC treatment response. Based on the heterogeneity of internal parametric tumor composition commonly observed, this study will utilize the histologic characteristics and treatment response to investigate the image features as input data for predicting treatment response using Deep Learning technology. Using this technique, preoperative treatment evaluation may be facilitated by tumor heterogeneity analysis from developed dynamic radiomics, and the possibility of personal medicine can be realized not far ahead. In the first two years of this study using images from DCE-MRI, PET/CT and QDS-IR, we plan to develop the image processing algorithms, including segmenting breast and tumor region, extracting image feature which reflects angiogenic properties and permeability of tumor, which are highly correlated with NAC treatment response. During the third year of the project, the morphology and texture features from first two years can be combined for PET/MRI and prediction model can be achieved in accordance with the features extracted from dynamic features extraction using longitudinal images of PET/MRI. conditions: Breast Cancer conditions: Chemotherapy Effect conditions: Diffusion Weighted MRI conditions: PET Imaging conditions: Multiparametric Magnetic Resonance Imaging studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 60 type: ACTUAL name: Whole body 18F-FDG Positron Emission Tomography measure: Model Prediction power of pathological complete response(pCR) measure: Comparison of models in prediction of pathological complete response(pCR) sex: FEMALE minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06370221 id: psoriatic Arthritis briefTitle: The Effect of Psoriatic Arthritis on Female Sexual Dysfunction overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-12-20 date: 2024-12-30 date: 2024-04-17 date: 2024-04-17 name: Egymedicalpedia class: INDUSTRY briefSummary: Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders. conditions: Psoriatic Arthritis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 180 type: ESTIMATED name: The effect of psoriatic Arthritis measure: Evaluation of female sexual function sex: FEMALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Qena Hospital city: Qinā country: Egypt name: Eisa Hegazy, Assist.Prof role: CONTACT phone: 01094337795 email: eisa_mohamed4152@med.svu.edu.eg lat: 26.16418 lon: 32.72671 hasResults: False
nctId: NCT06370208 id: LUMHS/B12/Temp/13.04.2024 briefTitle: Prophylactic Effect of Probiotic Streptococcus Salivarius K12 Against Recurrent Streptococcus Pyogenes Pharyngotonsillitis Infection in Pediatrics overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-11-30 date: 2024-12-31 date: 2024-04-17 date: 2024-04-17 name: Liaquat University of Medical & Health Sciences class: OTHER briefSummary: Recurrent Streptococcus pyogenes pharyngotonsillitis infection in children presents a significant health concern, characterized by frequent episodes of sore throat, fever, and swollen tonsils. These recurrent infections can lead to missed school days, discomfort, and potential complications if left untreated. Current treatment typically involves antibiotics to eradicate the bacterial infection. However, drawbacks exist with this approach, including the risk of antibiotic resistance, disruption of the gut microbiota, and potential adverse effects such as gastrointestinal upset or allergic reactions. Moreover, antibiotics do not prevent future episodes and may contribute to recurrent infections by disrupting the balance of the throat microbiome. Therefore, there is a growing interest in alternative approaches such as probiotics, which aim to support the body's natural defenses and restore microbial balance in the throat and oral cavity. conditions: Streptococcus Pyogenes Pharyngotonsillitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: Probiotic Bactoblis® (Streptococcus salivarius K12) measure: Recurrence of Streptococcus pyogenes pharyngotonsillitis infection measure: Probiotic safety and tolerability measure: Protection against viral infection measure: Protection against Acute Otitis Media infection measure: Protection against respiratory infection measure: Protection against Rhinitis measure: Protection against flu measure: Protection against Enteritis measure: Protection against Stomatitis sex: ALL minimumAge: 3 Years maximumAge: 10 Years stdAges: CHILD facility: Liaquat University of Medical and Health Sciences city: Jamshoro zip: 76090 country: Pakistan name: Dr. Ikram Ujjan, MBBS, PhD role: CONTACT phone: 03000506955 email: amjadkhan@lumhs.edu.pk lat: 25.43773 lon: 68.28522 hasResults: False
nctId: NCT06370195 id: SGB-Liuxian briefTitle: Effect of Stellate Ganglion Block on Drooling in Parkinson's Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2024-12 date: 2024-04-17 date: 2024-04-17 name: Babujinaya Cela class: OTHER_GOV briefSummary: This is a randomized controlled study, including dysphagic patients with Parkinson's syndrome who were received in the department of rehabilitation medicine. All patients are randomly allocated to the observation group or the control group. Both groups are provided with comprehensive rehabilitation. Besides, the observation group additionally undergoes the stellate ganglion block. At admission and after 10-day treatment, Functional Oral Intake Scale, Drooling amount, depression are assessed. conditions: Parkinson's Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Comprehensive rehabilitation name: Stellate ganglion block name: Lidocaine hydrochloride name: Placebo injection measure: Drooling amount measure: Modified Barthel Index measure: Patient Health Questionnaire-9 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06370182 id: ANA2401 briefTitle: Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA5 Device acronym: ATHENA overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2025-12 date: 2026-03 date: 2024-04-17 date: 2024-04-17 name: Anaconda Biomed S.L. class: INDUSTRY briefSummary: The objective of this study is to assess the safety and effectiveness of mechanical thrombectomy using the ANA funnel catheter to treat people with acute ischemic stroke within 24 hours of symptom onset. The device facilitates the placement of other devices such as stent retrievers and intravascular catheters during the procedure. conditions: Acute Ischemic Stroke From Large Vessel Occlusion studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 250 type: ESTIMATED name: ANA Funnel Catheter name: Control measure: Proportion of subjects with "near-complete" reperfusion after one thrombectomy pass (FPE, eTICI 2c-3, extended Thrombolysis in Cerebral Infarction scale) in the target vessel after one reperfusion attempt. measure: Rate of symptomatic intracranial hemorrhage (sICH), attributable to the device or procedure. sex: ALL minimumAge: 22 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06370169 id: ROSC 1 briefTitle: EUS Guided Coil Embolization for Primary Prophylaxis of Gastric Varices acronym: EUS overallStatus: RECRUITING date: 2022-08-01 date: 2024-03-30 date: 2024-08-10 date: 2024-04-17 date: 2024-04-17 name: Asian Institute of Gastroenterology, India class: OTHER briefSummary: The standard treatment of bleeding gastric varices is obliteration with placement of coil and glue. Our study will evaluate the efficacy of EUS guided coil as primary prophylaxis for high-risk gastric varices. All procedures will be performed with patient under deep sedation or general anaesthesia under the supervision of an anaesthesiologist. conditions: Gastric Varices Bleeding studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 50 type: ESTIMATED name: Endoscopic ultrasound placement of Coil and glue measure: The outcome will measure number of patient had achieved complete obliteration of varices measure: Number of patient needed re intervention measure: Number of patient needed had bleeding following intervention like immediate (with in 5 days) or later (5-90 days) sex: ALL minimumAge: 18 Months maximumAge: 80 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Asian institute of Gastroenterology status: RECRUITING city: Hyderabad state: Telangana zip: 500082 country: India name: Jahangeer Dr Basha, MD DM role: CONTACT phone: 04023378888 email: drjahangeer09@gmail.com name: Sandeep Dr Nath, MD role: CONTACT phone: 04023378888 email: sandip.nath@ymail.com lat: 17.38405 lon: 78.45636 hasResults: False
nctId: NCT06370156 id: TWEAK in plaque psoriasis briefTitle: Evaluation of TWEAK in Plaque Psoriasis and Psoriatic Arthritis Patients overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-06-01 date: 2025-06-10 date: 2024-04-17 date: 2024-04-17 name: Egymedicalpedia class: INDUSTRY briefSummary: Psoriasis vulgaris is associated with significant comorbidity including depression, increased risk of cardiovascular events, diminished quality of life, as well as overall increased mortality.
To enhance quality of life and potentially lower the risk of concomitant disease in psoriasis patients, effective treatment of this immune-mediated systemic inflammatory disease is required conditions: Plaque Psoriasis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Adalimumab measure: Treatment of psoriasis vulgaris and psoriatic arthritis measure: Evaluation of serum TWEAK sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: South Valley Hospitals city: Qinā country: Egypt name: Eisa Mohamed Hegazy, Professor role: CONTACT phone: +201094337795 email: eisa_mohamed4152@med.svu.edu.eg lat: 26.16418 lon: 32.72671 hasResults: False