nctId: NCT06311838 id: 2023H0244 briefTitle: Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2028-12 date: 2029-12 date: 2024-03-15 date: 2024-04-09 name: Ohio State University class: OTHER briefSummary: Homelessness severely affects health and well-being and is particularly negative for youth. Between 70-95% of youth experiencing homelessness (YEH) report problem substance use and 66-89% have a mental health disorder. Youth appear to be at greater risk for living on the streets or being homeless than adults and are more vulnerable to long term consequences of homelessness. Multiple social determinants of health (SDOH) are uniquely associated with homelessness, driving substance use and adverse mental health consequences. However, limited research has identified pragmatic interventions that have a long-term ameliorating impact on the complex, multi-symptomatic issues among these youth. This study overcomes prior gaps in research through testing a multi-component comprehensive prevention intervention targeting SDOH that may affect biopsychosocial health indicators and longer-term health outcomes. In partnership with a drop-in center for YEH, youth between the ages of 14 to 24 years, will be engaged and randomly assigned to conditions using a dismantling design so that essential intervention components can be efficiently identified. In particular, youth (N = 300) will be randomly assigned to a) Motivational Interviewing/Community Reinforcement Approach + Services as Usual (MI/CRA + SAU, n = 80), b) Strengths-Based Outreach and Advocacy + Services As Usual (SBOA + SAU, n = 80), c) MI/CRA + SBOA + SAU (n = 80) or d) SAU (n=60) through the drop-in center. In order to assess the longer-term prevention effects on substance use, mental health and other outcomes, all youth will be assessed at baseline and at 3, 6, 12, 18 and 24-months post-baseline. The primary goal of this study is to establish the impact of a comprehensive intervention embedded within a system that serves YEH, a community drop-in center, on youth's opioid misuse and disorder, other substance misuse and disorders, mental health diagnoses, and other targeted outcomes. This study will offer unique information on the physiological and psychological stress pathways underlying change for specific subgroups of youth along with cost estimates to inform future implementation efforts in drop-in centers around the country. conditions: Opioid Use Disorder conditions: Dual Diagnosis conditions: Housing Problems conditions: Mental Disorder in Adolescence conditions: Risk Behavior conditions: Homelessness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Using a dismantling, randomized controlled design, researchers will examine the singular and combined impact of Motivational Interviewing/Community Reinforcement Approach (MI/CRA) and Strengths-Based Outreach and Advocacy (SBOA) on substance use, mental health and other outcomes (e.g., housing stability, education, employment) with Youth Experiencing Homelessness (YEH) recruited from a local drop-in center. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Assessors will be blind to intervention condition. whoMasked: OUTCOMES_ASSESSOR count: 300 type: ESTIMATED name: Motivational Interviewing/Community Reinforcement Approach (MI/CRA) name: Strengths-Based Outreach and Advocacy (SBOA ) name: Services as Usual (SAU) measure: Form 90 Substance Use interview measure: Shortened Inventory of Problems - Alcohol and Drugs (SIP-AD) measure: Presence of drugs of abuse measure: Beck Depression Inventory II (BDI-II) measure: Beck Anxiety Inventory (BAI) measure: Short Form-12 sex: ALL minimumAge: 14 Years maximumAge: 24 Years stdAges: CHILD stdAges: ADULT facility: Star House city: Columbus state: Ohio zip: 43201 country: United States name: Natasha Slesnick, PhD role: CONTACT phone: 614-247-8469 email: slesnick.5@osu.edu lat: 39.96118 lon: -82.99879 facility: Ohio State University city: Columbus state: Ohio zip: 43210 country: United States name: Jodi Ford, PhD role: CONTACT phone: 614-292-6862 email: ford.553@osu.edu name: Natasha Slesnick, PhD role: CONTACT phone: (614) 247-8469 email: slesnick.5@osu.edu name: Jodi Ford, PhD role: PRINCIPAL_INVESTIGATOR name: Natasha Slesnick, PhD role: PRINCIPAL_INVESTIGATOR lat: 39.96118 lon: -82.99879 hasResults: False