nctId: NCT06340295 id: 2023313 briefTitle: A Multicenter, Prospective Cohort Study of Preserved Ratio Impaired Spirometry(PRISm) in a Population overallStatus: RECRUITING date: 2023-09-01 date: 2026-05-31 date: 2026-05-31 date: 2024-04-01 date: 2024-04-01 name: Peking University First Hospital class: OTHER name: Shanxi Bethune Hospital name: First Affiliated Hospital Xi'an Jiaotong University name: Tianjin Medical University General Hospital name: The First Hospital of Qinhuangdao name: Shandong Provincial Hospital name: Second Hospital of Jilin University name: People's Hospital of Xinjiang Uygur Autonomous Region name: MinDong Hospital of Ningde City briefSummary: Chronic obstructive pulmonary disease (COPD) is the most common chronic tract disease and the third leading cause of death worldwide. The treatment effect of COPD is poor, and the disease is progressive, resulting in a serious disease burden. The key reason is that early recognition is difficult and the early pathophysiological mechanism is unclear, which leads to the difficulty of early intervention.PRISm is likely to be the precursor stage of COPD, which may provide an important research object for the study of pathophysiological characteristics, inflammation and immunomodulatory mechanisms of early COPD, and may also become a new entry point for early intervention of COPD. This study attempts to establish a PRISm prospective cohort，and collects blood, EBC and urine for analysis of inflammatory factors, metabolomics, proteomics and microbiome, and performs chest HRCT to obtain imaging indicators, and conducts 3-year dynamic follow-up observation to study the evolution characteristics of pulmonary function and the incidence of COPD in the PRISm cohort. To compare the differences in imaging, inflammatory factors, metabolomics, proteomics and microbiome among the three PRISm groups, and establish a risk prediction model for progression to COPD through PRISm. It lays a foundation for understanding the characteristics of COPD at an earlier stage and exploring new early warning indicators. conditions: COPD studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2000 type: ESTIMATED measure: The number and proportion of newly diagnosed COPD measure: The number and proportion of continuous PRISm population measure: The number and proportion of PRISm to normal population measure: Emerging diseases measure: Death and cause of death sex: ALL minimumAge: 20 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking University First Hospital status: RECRUITING city: Beijing state: Beijing zip: 100034 country: China name: Jiping Liao, MD. role: CONTACT phone: 13521714181 email: colorfulwing01@163.com name: Chunbo Zhang role: CONTACT phone: 13086645758 email: 2399637945@qq.com name: Jiping Liao, MD. role: PRINCIPAL_INVESTIGATOR name: Guangfa Wang, MD. role: SUB_INVESTIGATOR name: Zhe Jin, MD. role: SUB_INVESTIGATOR name: Meng Zhang role: SUB_INVESTIGATOR name: Yan Hu, MD. role: SUB_INVESTIGATOR name: Chunbo Zhang role: SUB_INVESTIGATOR name: Xueying Li role: SUB_INVESTIGATOR name: Jian Chen role: SUB_INVESTIGATOR lat: 39.9075 lon: 116.39723 facility: Peking University First Hospital status: RECRUITING city: Beijing state: Beijing zip: 100034 country: China name: Guangfa Wang, MD role: CONTACT phone: 13810644029 email: wangguangfa@hotmail.com name: Jiping Liao, MD role: CONTACT phone: 13521714181 email: colorfulwing01@163.com name: Yunxia Wang, PhD role: SUB_INVESTIGATOR name: Yijue Zhong, PhD role: SUB_INVESTIGATOR name: Chao Sun, PhD role: SUB_INVESTIGATOR lat: 39.9075 lon: 116.39723 facility: The First Hospital of Qinhuangdao status: RECRUITING city: Qinhuangdao state: Hebei country: China name: Hua Qiao, MD role: CONTACT phone: 13780358298 email: qh1202@163.com lat: 39.93167 lon: 119.58833 facility: Tianjin Medical University General Hospital status: RECRUITING city: Tianjin state: Tianjin country: China name: Lixia Dong, MD role: CONTACT phone: 13001385918 email: luckydonglixia@163.com lat: 39.14222 lon: 117.17667 facility: Shandong Provincial Hospital Affiliated to Shandong University status: RECRUITING city: Jing'an country: China name: Jian Sun, MD role: CONTACT email: docbenjaminsun@163.com facility: Shanxi Bethune Hospital status: RECRUITING city: Taiyuan country: China name: Ruiying Wang, MD role: CONTACT phone: +86 13903436432 email: wry0526@163.com lat: 37.86944 lon: 112.56028 hasResults: False