hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06270277 id: 30.01.2024-4272 briefTitle: Evaluation of Quality of Life and Psychosocial Status in Children With Inflammatory Bowel Disease overallStatus: COMPLETED date: 2024-02-14 date: 2024-02-20 date: 2024-02-21 date: 2024-02-21 date: 2024-02-22 name: Sisli Hamidiye Etfal Training and Research Hospital class: OTHER briefSummary: Inflammatory bowel disease (IBD) is a chronic condition that affects the psychosocial status and physical activities of children and their parents in many ways. Our study aimed to investigate the variability of disease-related quality of life and behavioral and emotional adjustment issues compared to a healthy control group among adolescents and their families diagnosed with IBD. Children with IBD and the healthy control group, as well as the parents of both groups, will administered the Pediatric Quality of Life Inventory (PedsQL) and Strengths and Difficulties Questionnaire (SDQ). The PedsQL is a scale used to assess physical and psychosocial functioning based on the individual's own experiences, commonly employed in clinical trials and quality improvement initiatives. The scale evaluates physical activity status and psychosocial functioning through questions related to emotional, social, and school-related issues. conditions: Inflammatory Bowel Diseases conditions: Psychosocial Impairment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Adolescents with Inflammatory bowel diseases and healthy control group in same age will be administered Pediatric Quality of Life Inventory (PedsQL) and Strengths and Difficulties Questionnaire (SDQ). primaryPurpose: DIAGNOSTIC masking: NONE count: 159 type: ACTUAL name: Pediatric Quality of Life Inventory (PedsQL) name: Strengths and Difficulties Questionnaire (SDQ) measure: Pediatric Quality of Life Inventory (PedsQL) score measure: Strengths and Difficulties Questionnaire (SDQ) sex: ALL minimumAge: 8 Years maximumAge: 17 Years stdAges: CHILD facility: Sisli Hamidiye Etfal Research and Training Hospital city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06270264 id: 111-2023 briefTitle: Nociception Monitoring in Intensive Care overallStatus: COMPLETED date: 2023-08-01 date: 2023-12-15 date: 2024-01-01 date: 2024-02-21 date: 2024-02-21 name: Haseki Training and Research Hospital class: OTHER briefSummary: Precisely, pain in the ICU is a multidimensional problem with a multivariate of reasons. Still, it would be simpler to manage it in unconscious palliative patients with less source of pain, but only if we can detect it practically with the help of nociception monitors. Using five parameters, nociception level index (NOL) monitoring (Medasense) is differentiated from its alternatives. Other than pain detection, this monitoring can titrate analgesic administration. This study investigates the validity of a new nociception monitoring tool, the nociception level index, and its practical impact on providing adequate analgesia in palliative patients in intensive care. conditions: Unconscious State conditions: Pressure Ulcer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: randomized, prospective and controlled primaryPurpose: TREATMENT masking: NONE count: 40 type: ACTUAL name: the Nociception level index monitoring measure: total fentanyl consumption measure: systolic blood pressure measure: heart rate sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Haseki Training and Research Hospital city: Istanbul state: Sultangazi country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06270251 id: PSYCH-2023-32292 briefTitle: Modeling Tic Change During Behavior Therapy for Tics overallStatus: RECRUITING date: 2024-03-01 date: 2028-03-01 date: 2028-09-01 date: 2024-02-21 date: 2024-04-01 name: University of Minnesota class: OTHER briefSummary: Chronic tics are a disabling neuropsychiatric symptom associated with multiple child-onset mental disorders. Chronic tics affect 1-3% of youth and can be associated with impaired functioning, emotional and behavioral problems, physical pain, diminished quality of life, and peer victimization. Chronic tics are the primary symptom of Tourette Syndrome (TS) and Persistent Motor/Vocal Tic Disorders.
CBIT is a manualized treatment focused on increasing tic controllability. Its core procedure is competing response training (CRT), in which patients learn to inhibit tics by learning and applying a competing motor action to one tic at a time. CBIT is recommended as a first-line treatment relative to medications and other therapies. However, only 52% of children and 38% of adults show clinically meaningful tic improvement. Large randomized trials have demonstrated the superiority of CBIT over supportive therapy in child and adult patients, and meta-analysis shows comparable effect sizes for CBIT and medication. Although increasing tic controllability is the primary goal of CBIT, tic controllability nor its correlates have been examined longitudinally during the intervention.
The overall objective of this study is to use fine-grained data collection strategies to identify patterns in tic controllability and other relevant related variables that are associated with treatment response to CBIT. Participants with chronic tics will complete a manualized course of 8-session CBIT. Behavioral, psychosocial, and global functioning will be assessed longitudinally to examine predictors and correlates of response. CBIT sessions will be video recorded. conditions: Chronic Tic Disorder studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: CBIT measure: Tic Severity measure: Sheehan Disability scale measure: Behavior Rating Inventory of Executive Function measure: Ask Suicide-Screening Questions (ASQ) measure: Child Attitudes Toward Illness Scale (CATIS) measure: Rosenberg Self-Esteem Scale measure: Caregiver Strain Questionnaire measure: Clinical Global Impressions (CGI) measure: Parent/Adult Tic Questionnaire measure: Premonitory Urge for Tics Scale measure: Tic Suppression Task measure: Stop signal task sex: ALL minimumAge: 12 Years maximumAge: 21 Years stdAges: CHILD stdAges: ADULT facility: University of Minnesota status: RECRUITING city: Minneapolis state: Minnesota zip: 55414 country: United States name: Brianna Wellen role: CONTACT lat: 44.97997 lon: -93.26384 hasResults: False
nctId: NCT06270225 id: SSGJ-613-PGF-II-01 briefTitle: A Study of SSGJ-613 in Gout Subjects Initiating Urate-Lowering Treatment. overallStatus: RECRUITING date: 2024-03-30 date: 2024-06 date: 2024-12 date: 2024-02-21 date: 2024-04-10 name: Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. class: INDUSTRY briefSummary: The purpose of this study is to determine the efficacy and safety of recombinant anti-interleukin-1β humanized monoclonal antibody injection in Chinese gout participants Initiating Urate-Lowering Treatment. conditions: Gout Arthritis studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 150 type: ESTIMATED name: Recombinant Anti-IL-1β Humanized Monoclonal Antibody Injection 100 mg name: Recombinant Anti-IL-1β Humanized Monoclonal Antibody Injection 200 mg name: Colchicine 0.5 mg measure: Numbers of acute gout flares measure: Numbers of acute gout flares measure: Proportions of subjects with at least 1 acute gout flare measure: Proportions of subjects with at least 1 acute gout flare measure: Time from randomization to first acute flare. measure: Duration of acute gout flares. measure: Duration of acute gout flares. measure: Subject's overall assessment of response to treatment measure: Investigator's overall assessment of response to treatment measure: 36-item Short Form Survey (SF-36) measure: Adverse events (AE) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai Huashan Hospital Fudan University-Rheumatology status: RECRUITING city: Shanghai state: Shanghai zip: 200040 country: China name: Hejian Zou, MD role: CONTACT phone: +86 13311881366 email: hjzou@fudan.edu.cn name: Hejian Zou role: PRINCIPAL_INVESTIGATOR lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06270212 id: CIV-ID 23-08-043797 briefTitle: Medical Device for Airway Patency During Sedation acronym: STAIRWAY-2 overallStatus: RECRUITING date: 2024-02-01 date: 2024-06-30 date: 2024-12-31 date: 2024-02-21 date: 2024-02-21 name: Stairway Medical AB class: INDUSTRY name: Lund University briefSummary: OVERALL SYNOPSIS
* of perceived sedational comfort, of sedational and procedural usability, and of sedational and procedural preference with STAIRWAY vs. standard procedure (biteblock or no device) during PS according to SOC for scheduled diagnostic or therapeutic procedures planned to be carried out under PS with propofol in spontaneously breathing study patients. conditions: Airway Obstruction conditions: Sedation Complication conditions: Perioperative Complication studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Prospective randomized unpaired, and paired crossover, evaluations of study outcome measures in healthy volunteer study participants (PART A), and prospective randomized unpaired evaluation of study outcome measures in study patients (PART B).
The number of enrolled study participants reported below (46) refers to evaluable ones. whoMasked: OUTCOMES_ASSESSOR count: 46 type: ESTIMATED name: STAIRWAY name: NO DEVICE measure: Transpharyngeal distance during moderate-to-deep steady-state sedation. measure: Duration of manual airway support during PS for clinical procedures. measure: Transpharyngeal distance during mild steady-state sedation. measure: Duration of interrupted capnometric monitoring during sedation. measure: Duration of manual airway support during induction of steady-state sedation. measure: Sedational comfort measure: Conditions for sedation measure: Conditions for procedural intervention sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Skåne University Hospital status: RECRUITING city: Malmö state: Skåne zip: 20502 country: Sweden name: Magnus Ljungvall, MD role: CONTACT phone: +46-705445502 email: magnus.ljungvall@med.lu.se name: Jonas Åkeson, PhD, Professor role: CONTACT phone: +46-708311113 email: jonas.akeson@med.lu.se lat: 55.60587 lon: 13.00073 hasResults: False
nctId: NCT06270186 id: 20-AOIP-04 briefTitle: Evaluation of Cognitive Functions in 20 Patients With Type 1 Myotonic Dystrophy With Virtual Reality Approach acronym: GoodDiagNMD overallStatus: WITHDRAWN date: 2023-11 date: 2024-11 date: 2024-11 date: 2024-02-21 date: 2024-02-21 name: Centre Hospitalier Universitaire de Nice class: OTHER briefSummary: Type 1 myotonic dystrophy (MD1) is a genetic and hereditary disease that primarily affects muscle tissue, resulting in myotonia (difficulty relaxing after contraction) and atrophy (progressive muscle weakening with decreased muscle volume). It also affects eyes, heart, endocrine system, gastrointestinal system and central nervous system. Specific cognitive abilities are impaired in patients with MD1 such as attention, visio-spatial or visio-building abilities as well as executive dysfunctions.
The start-up My Cyber Royaume from Lille, in collaboration with the reference center of neuromuscular diseases from Nice coordinated by Pr Sacconi, have developed a software "Good Diag NMD" which uses virtual reality to assess cognitive disorders, more specifically executive functions in patients with type 1 myotonic dystrophy. conditions: Myotonic Dystrophy 1 studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 0 type: ACTUAL name: Type 1 myotonic dystrophy measure: Evaluate the feasibility of the use "Good Diag NMD" software in the evaluation of cognitive executive dysfunctions in patients with dystrophy myotonia 1 measure: Establish a possible relationship between the genotype of DM1 patients and the scores obtained during "Good Diag NMD" session measure: To compare the satisfaction score of type 1 myotonic dystrophy patients between classic neuropsychological tests and the Good Diag NMD session measure: Compare the scores of "Good Diag NMD" session (scores of perseveration, inhibition and flexibility) with the scores of the classical neuropsychological tests measure: Establish a possible correlation between the severity of the disease, the severity of muscular impairment and the scores of Good Diag NMD session sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06270173 id: TWM-C-2202 briefTitle: Post-Market Study of The Tripod-Fix Vertebral Body Augmentation System in Osteoporotic Vertebral Compression Fractures overallStatus: RECRUITING date: 2024-02-16 date: 2025-07-31 date: 2025-12-31 date: 2024-02-21 date: 2024-02-21 name: Wiltrom Co., Ltd. class: INDUSTRY name: Maxis Medical GmbH briefSummary: The objective of this Post-Market Clinical Follow-Up Study is to evaluate the safety and performance of the Tripod-Fix in the treatment of vertebral compression fractures (VCF) resulting from osteoporosis. conditions: Osteoporotic Vertebral Compression Fractures studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: Tripod-Fix Vertebral Body Augmentation System (Tripod-Fix) measure: Proportion of participants with study success sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Klinikum Friedrichshafen status: NOT_YET_RECRUITING city: Friedrichshafen state: Baden-Württemberg zip: 88048 country: Germany name: Ludwig Oberkircher, Prof Dr med role: PRINCIPAL_INVESTIGATOR lat: 47.65689 lon: 9.47554 facility: University Hospital Mannheim status: NOT_YET_RECRUITING city: Mannheim state: Baden-Württemberg zip: 68167 country: Germany name: Frederic Bludau, PD Dr med role: PRINCIPAL_INVESTIGATOR lat: 49.4891 lon: 8.46694 facility: Johann Wolfgang Goethe University Frankfurt/Main status: NOT_YET_RECRUITING city: Frankfurt am Main state: Hesse zip: 60596 country: Germany name: Thomas Vogl, Prof Dr med role: PRINCIPAL_INVESTIGATOR lat: 50.11552 lon: 8.68417 facility: Krankenaus Mechernich status: RECRUITING city: Mechernich state: North-Rhine-Westphalia zip: 53894 country: Germany name: Robert Pflugmacher, Prof Dr med role: PRINCIPAL_INVESTIGATOR lat: 50.59304 lon: 6.65224 hasResults: False
nctId: NCT06270160 id: KampalaLivelihoodsStudy briefTitle: Livelihoods Intervention With Urban Refugee Youth in Kampala, Uganda overallStatus: RECRUITING date: 2024-03-01 date: 2024-08-01 date: 2024-12-31 date: 2024-02-21 date: 2024-03-01 name: University of Toronto class: OTHER briefSummary: Displaced and refugee youth in Uganda are more vulnerable to health risks due to financial insecurity. As such, the investigators aim to explore the utility of an intervention aimed at improving livelihoods, called Creating Futures. Creating Futures is a group intervention that aims to help young people build their livelihoods, and was designed for use with youth (18-24) in urban informal settlements in South Africa.
Since there is a dearth of knowledge regarding efficacious interventions in refugee camps/settlements to engage young people in HIV testing and linkage to care, the investigators will harness various health promotion techniques including mHealth, comics, and the Creating Futures livelihoods intervention to address the urgent needs for: 1) HIV testing interventions with refugee/displaced adolescent and young people in Kampala, and 2) innovative HIV self test (HIVST) delivery strategies to increase linkage to confirmatory testing and HIV care. The investigators will conduct a three-arm cluster randomized controlled trial (cRCT) to evaluate the effectiveness of HIVST delivery methods among AYP living in Kampala. The specific objectives are to: Evaluate the feasibility and effectiveness of: 1) HIVST alone; 2) HIVST in combination with mHealth; and 3) HIVST, mHealth and Creating Futures in combination in increasing routine HIV testing, HIV status knowledge, and linkage to confirmatory testing and HIV care. The investigators aim to examine if adding a livelihoods program to HIV self-testing improves HIV prevention outcomes and other facets of well-being among urban refugee youth in Kampala. conditions: Financial Stress conditions: Social Functioning conditions: Social Skills studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The intervention arms will be compared to the control arm of the study using a pre- and post-intervention survey. There will also be a follow-up survey after the study is complete. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 432 type: ESTIMATED name: HIVST name: mHealth name: Creating Futures Livelihoods program measure: Number of participants engaged in HIV testing measure: Number of participants with knowledge of their HIV status measure: Number of participants linked to confirmatory HIV testing measure: Frequency of linkage to HIV care measure: Brief HIV Knowledge Questionnaire measure: Sexual Risk sex: ALL minimumAge: 16 Years maximumAge: 25 Years stdAges: CHILD stdAges: ADULT facility: Young African Refugees for Integral Development status: RECRUITING city: Kampala country: Uganda name: Robert Hakiza role: CONTACT phone: 256 2009 12345 email: roberthakiza2001@gmail.com lat: 0.31628 lon: 32.58219 hasResults: False
nctId: NCT06270147 id: 16935 briefTitle: Timing of TAP Blocks in Bariatric Surgery overallStatus: NOT_YET_RECRUITING date: 2024-03-04 date: 2024-06-28 date: 2024-06-28 date: 2024-02-21 date: 2024-02-21 name: McMaster University class: OTHER briefSummary: This clinical trial aims to determine the optimal timing for administering a Transversus Abdominis Plane (TAP) block in bariatric surgery, specifically investigating whether initiating TAP blocks at the beginning of surgery is more beneficial than at the end, which is the current practice. The study targets obese patients undergoing bariatric surgery, with a focus on reducing postoperative pain and opioid use. Key outcomes include recovery duration, pain levels, opioid consumption, and respiratory function. Successful results could establish early TAP block initiation as a standard practice, offering faster recovery, decreased opioid reliance, and reduced healthcare costs. conditions: Opioid Use conditions: Pain, Postoperative studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Bupivacaine-epinephrine measure: Opioid Consumption measure: Length of Stay measure: Anesthesia requirements measure: Sedation requirements measure: Nausea and vomiting measure: Respiratory Status measure: Opioid consumption sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06270134 id: 14410 briefTitle: Dial-Bicarb Trial: Effects of a Lower vs. Higher Concentration of Dialysate Bicarbonate overallStatus: NOT_YET_RECRUITING date: 2025-01 date: 2029-01 date: 2029-01 date: 2024-02-21 date: 2024-02-21 name: McMaster University class: OTHER name: Canadian Institutes of Health Research (CIHR) briefSummary: This is a pragmatic, two-arm, parallel-group, open-label, individual-randomized, superiority trial that will be conducted in hemodialysis units across Ontario. Patients at each dialysis unit will be randomly allocated into one of two study arms in a 1:1 ratio to receive a dialysate bicarbonate concentration of either 32 or 38 mmol/L. The intervention will be embedded into routine care and delivered by hemodialysis unit personnel. conditions: Hemolysis conditions: Renal Failure studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a pragmatic, two-arm, parallel-group, open-label, individual-randomized, superiority trial that will be conducted in hemodialysis units across Ontario. Patients at each dialysis unit will be randomly allocated into one of two study arms in a 1:1 ratio to receive a dialysate bicarbonate concentration of either 32 or 38 mmol/L. primaryPurpose: TREATMENT masking: NONE count: 5000 type: ESTIMATED name: Bicarbonate measure: Non-elective hospitalizations or mortality measure: Hospitalizations and fractures sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06270121 id: R2111483 briefTitle: Development of a Healthcare Service Platform for Successful Aging overallStatus: RECRUITING date: 2020-10-21 date: 2026-11-30 date: 2030-11-30 date: 2024-02-21 date: 2024-02-21 name: Sunmi Song class: OTHER briefSummary: The goal of this living-lab clinical trial is to test the effectiveness of digital health monitoring and feedback platform for community dwelling older adults. The main questions it aims to answer are:
If there is a comparison group: Researchers will compare age and gender matched control group to see if health status of the living-lab group is better than the control group. conditions: Depression in Old Age conditions: Chronic Pain conditions: Sleep Disorder Insomnia Chronic studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: PREVENTION masking: SINGLE maskingDescription: Control group was informed that they participated in the study with a repeated measure survey about digital healthcare for elderly without detailed descriptions on the living-lab intervention. whoMasked: PARTICIPANT count: 84 type: ESTIMATED name: Living-lab digital intervention group measure: Patient Health Questionnaire-9 (PHQ-9) measure: Sleep fragmentation index measure: Daily steps measure: Intensity of physical activity measure: Heart rate variability measure: Geriatic depression measure: SF-12 Quality of life measure: Pain related functional limitations measure: Chronic pain sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Korea University status: RECRUITING city: Seoul zip: 02841 country: Korea, Republic of name: Sunmi Song, PhD role: CONTACT phone: +821087489593 email: sunmi.song0715@gmail.com lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06270108 id: 22/SS/0040 id: 299382 type: OTHER domain: Integrated Research Application System briefTitle: The Role of Glutamatergic Function in the Pathophysiology of Treatment-resistant Schizophrenia acronym: RESTORE overallStatus: RECRUITING date: 2022-11-14 date: 2024-12-31 date: 2024-12-31 date: 2024-02-21 date: 2024-03-05 name: King's College London class: OTHER name: South London and Maudsley NHS Foundation Trust briefSummary: The goal of this basic science study is to to explore the responsivity of glutamate in the brain of treatment-resistant schizophrenia patients to the drug riluzole. The main aims of the study are: