Participants will be asked to attend clinic and be given a intravenous infusion of CRB-701 on its own. They will have blood tests and other assessments to measure whether CRB-701 will have CT or MRI scans to measure the effect on tumors. conditions: Solid Tumor, Adult studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: A three part study primaryPurpose: TREATMENT masking: NONE count: 420 type: ESTIMATED name: CRB-701 measure: Part A: To confirm the safety and tolerability and determine MTD and PADR for CRB-701 measure: Part B & C : To evaluate efficacy in terms of Disease Control Rate (DCR) measure: Part B & C: To evaluate efficacy in terms of Objective Response Rate (ORR) measure: Parts A, B, % C: To characterize the safety profile of CRB-701 measure: Maximum observed plasma concentration of CRB-701 [total ADC] (Cmax) measure: Maximum observed plasma concentration of free MMAE (Cmax) measure: Maximum observed plasma concentration of Total CRB-701 antibody [Tab] (Cmax) measure: Time to reach Cmax of Total CRB-701 [Total ADC] (Tmax) measure: Time to reach Cmax of free MMAE (Tmax) measure: Time to reach Cmax of Total CRB-701 antibody [Tab] (Tmax) measure: Time to reach Cmax of Total CRB-701 antibody [Tab] (Cmax) measure: Total Area Under the plasma concentration-time curve of Total CRB-701 [total ADC] (AUC) measure: Total Area Under the plasma concentration-time curve of free MMAE (AUC) measure: Total Area Under the plasma concentration-time curve of Total CRB-701 antibody [Tab] (AUC) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Moores Cancer Centre at UC San Diego Health status: NOT_YET_RECRUITING city: San Diego state: California zip: 92037 country: United States name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 32.71533 lon: -117.15726 facility: Helen Diller Family Comprehensive Cancer Center - UCSF status: NOT_YET_RECRUITING city: San Francisco state: California zip: 94115 country: United States name: Rodney Carter role: CONTACT email: clinical@corbuspharma.com lat: 37.77493 lon: -122.41942 facility: Rocky Mountain Cancer Centres status: NOT_YET_RECRUITING city: Denver state: Colorado zip: 80218 country: United States name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 39.73915 lon: -104.9847 facility: Yale Cancer Center status: NOT_YET_RECRUITING city: New Haven state: Connecticut zip: 06510 country: United States name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 41.30815 lon: -72.92816 facility: Florida Cancer Specialists status: NOT_YET_RECRUITING city: Orlando state: Florida zip: 32806 country: United States name: Rodney Carter role: CONTACT email: clinical@corbuspharma.com lat: 28.53834 lon: -81.37924 facility: University of Chicago status: NOT_YET_RECRUITING city: Chicago state: Illinois zip: 60637 country: United States name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 41.85003 lon: -87.65005 facility: Hope and Healing Cancer Center status: RECRUITING city: Hinsdale state: Illinois zip: 60521 country: United States name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 41.80086 lon: -87.93701 facility: Dana-Faber Cancer Institute status: NOT_YET_RECRUITING city: Boston state: Massachusetts zip: 02215 country: United States name: Rodney Carter role: CONTACT lat: 42.35843 lon: -71.05977 facility: Nebraska Hematology Oncology status: RECRUITING city: Lincoln state: Nebraska zip: 68506 country: United States name: Rodney Carter role: CONTACT email: clinical@corbuspharma.com lat: 40.8 lon: -96.66696 facility: Carolina BioOncology Institute status: RECRUITING city: Huntersville state: North Carolina zip: 28078 country: United States name: Rodney Carter role: CONTACT email: clinical@corbuspharma.com lat: 35.41069 lon: -80.84285 facility: Texas Oncology status: NOT_YET_RECRUITING city: Tyler state: Texas zip: 75702 country: United States name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 32.35126 lon: -95.30106 facility: Virginia Cancer Specialists status: NOT_YET_RECRUITING city: Fairfax state: Virginia zip: 22031 country: United States name: Rodney Carter role: CONTACT email: clinical@corbuspharma.com lat: 38.84622 lon: -77.30637 facility: Barcelona IOB Hospital Quironsalud (NEXT) status: NOT_YET_RECRUITING city: Barcelona zip: 08023 country: Spain name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 41.38879 lon: 2.15899 facility: Vall d-Hebron Institut d'Oncologia status: NOT_YET_RECRUITING city: Barcelona zip: 08035 country: Spain name: Rodney Carter role: CONTACT email: clinical@corbuspharma.com lat: 41.38879 lon: 2.15899 facility: Fundacion Jimenez Diaz (START) status: NOT_YET_RECRUITING city: Madrid zip: 28040 country: Spain name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 40.4165 lon: -3.70256 facility: Hospital Clinico Universitario de Valencia status: NOT_YET_RECRUITING city: Valencia zip: 46010 country: Spain name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 39.46975 lon: -0.37739 facility: Adana Numune Egitim ve Arastirma Hastanesi (Adana City Education and Research Hospital) status: NOT_YET_RECRUITING city: Adana zip: 83114 country: Turkey name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 37.00167 lon: 35.32889 facility: Ankara Etlik City Hospital status: NOT_YET_RECRUITING city: Ankara country: Turkey name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 39.91987 lon: 32.85427 facility: Ankara University status: NOT_YET_RECRUITING city: Ankara country: Turkey name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 39.91987 lon: 32.85427 facility: Istanbul Medeniyet University status: NOT_YET_RECRUITING city: Istanbul zip: 34720 country: Turkey name: Rodney Carter role: CONTACT email: Clincal@corbuspharma.com lat: 41.01384 lon: 28.94966 facility: University of Birmingham NHS Foundation Trust status: NOT_YET_RECRUITING city: Birmingham zip: B15 2TH country: United Kingdom name: Rodney Carter role: CONTACT email: clinical@corbuspharma.com lat: 52.48142 lon: -1.89983 facility: University of Cambridge NHS Foundation Trust status: NOT_YET_RECRUITING city: Cambridge zip: CB2 0QQ country: United Kingdom name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 52.2 lon: 0.11667 facility: Velindre Cancer Centre status: NOT_YET_RECRUITING city: Cardiff zip: CF15 7QZ country: United Kingdom name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 51.48 lon: -3.18 facility: Leeds University Hospitals NHS Trust status: NOT_YET_RECRUITING city: Leeds zip: LS9 7LP country: United Kingdom name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 53.79648 lon: -1.54785 facility: Guy's and St Thomas' Clinical Research Facility status: NOT_YET_RECRUITING city: London zip: SE1 9RT country: United Kingdom name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 51.50853 lon: -0.12574 facility: Imperial Experimental Cancer Medicine Centre status: NOT_YET_RECRUITING city: London zip: W12 0NN country: United Kingdom name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 51.50853 lon: -0.12574 facility: The Christie Hospital status: NOT_YET_RECRUITING city: Manchester zip: M20 4BX country: United Kingdom name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 53.48095 lon: -2.23743 facility: University of Southampton status: NOT_YET_RECRUITING city: Southampton zip: SO16 6YD country: United Kingdom name: Rodney Carter role: CONTACT email: clinical@corbuspharma.com lat: 50.90395 lon: -1.40428 facility: University of Liverpool - Clatterbridge Medical Centre status: NOT_YET_RECRUITING city: Wirral zip: CH63 4JY country: United Kingdom name: Rodney Carter role: CONTACT email: Clinical@corbuspharma.com lat: 53.37616 lon: -3.10501 hasResults: False