hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06295536 id: WS10363 briefTitle: Optimization of a Photoretinoscopy Method for Determining the Objective Refraction of Children overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-08 date: 2024-08 date: 2024-03-06 date: 2024-03-06 name: Essilor International class: INDUSTRY briefSummary: The objective is to compare the refractive parameters of the photorefraction prototype device without cycloplegia with the refractive parameters of reference device, an autorefractometer with and without cycloplegia. conditions: Ametropia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 115 type: ESTIMATED name: Comparator device, Closed-field autorefractometer measure: Objective refractive error sex: ALL minimumAge: 6 Years maximumAge: 13 Years stdAges: CHILD hasResults: False
nctId: NCT06295523 id: STU_2019_1759_COPD briefTitle: Heat Waves and the Elderly With COPD overallStatus: RECRUITING date: 2024-01-01 date: 2025-12 date: 2025-12 date: 2024-03-06 date: 2024-03-06 name: University of Texas Southwestern Medical Center class: OTHER name: American Heart Association briefSummary: The purpose of this study is to investigate thermoregulatory responses in older individuals with COPD. conditions: COPD conditions: Aging conditions: Hyperthermia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: NONE count: 44 type: ESTIMATED name: Water Spray name: Control measure: Core body temperature measure: Forced expiratory volume (FEV1) measure: Forced vital capacity (FVC) measure: FEV1/FVC ratio sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Texas Health Presbyterian Hospital Dallas status: RECRUITING city: Dallas state: Texas zip: 75231 country: United States name: Whitley Atkins, PhD role: CONTACT name: Courtney Kirby, BS RN role: CONTACT phone: 214-345-6502 name: Craig Crandall, PhD role: PRINCIPAL_INVESTIGATOR lat: 32.78306 lon: -96.80667 hasResults: False
nctId: NCT06295510 id: CDUTCM20240223 briefTitle: Observational Study of the Association Between Food Intake and Endometrial Polyps overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-04-01 date: 2024-05-01 date: 2024-03-06 date: 2024-03-06 name: qinxiu zhang class: OTHER briefSummary: There are currently no studies evaluating the association between diet and the incidence of endometrial polyps. We aim to evaluate the association to provide more recommendations for the early prevention of endometrial polyps. conditions: Diet Habit conditions: Endometrial Polyp conditions: Women studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 150 type: ESTIMATED name: No interventions. measure: Hormonal dietary intake measure: Comparison of daily living habits sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06295497 id: LC-SHIELD briefTitle: Lung Cancer Screening by Artificial Intelligence Device overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-06-30 date: 2027-12-31 date: 2024-03-06 date: 2024-03-06 name: Chinese University of Hong Kong class: OTHER briefSummary: Lung cancer screening is currently not recommended in non-smokers due to paucity of evidence. Emerging evidence suggests that first-degree family history is a strong risk factor for lung cancer in Asian non-smokers. In Asia, lack of resource is a major challenge in successful implementation of lung cancer screening. Artificial intelligence (AI) is a promising tool to overcome this resource. In this study, we aim to study the clinical utility and demonstrate the feasibility of using an AI assisted programme for lung cancer screening in Asian non-smokers with a positive family history. This is a single-arm non-randomized lung cancer screening study. 1000 non-smokers, age 50 to 75 year old, with a first-degree family history of lung cancer, will be enrolled. Participants will undergo low does computed tomography (LDCT) of thorax and blood taking at enrolment. LDCT films will be interpreted by AI softwares for presence of lung nodules. Participants with lung nodules will be further investigated and followed up according to the risk of malignancy. The primary endpoint is the prevalence of early-staged lung cancer detected by first-round LDCT thorax in this population. conditions: Lung Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 1000 type: ESTIMATED name: Lung-SIGHT measure: The prevalence of early-staged lung cancer detected by first-round LDCT thorax (T0) in a high-risk non-smoker population measure: Sensitivity of AI-assisted programme in lung nodule detection and monitoring compared to radiologist assessment measure: Rate of invasive workup and incidence of associated complications. measure: Prevalence of lung cancer detected by second-round LDCT (T1) in patients with negative first-round LDCT measure: Diagnostic accuracy and discrimination ability of plasma-based fragmentomic assay in detection of lung cancer via assessment of sensitivity, specificity, positive predictive value and negative predictive value measure: To determine the quality adjusted life years (QALYs) gained through screening sex: ALL minimumAge: 50 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Clinical Oncology, Prince of Wales Hospital city: Hong Kong country: Hong Kong name: Molly SC LI, MBBS, MRCP role: CONTACT phone: 3505 2166 email: molly@clo.cuhk.edu.hk lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06295484 id: 5136 briefTitle: Effect of Nasal CPAP Versus NIPPV On Diaphragm Electrical Activity (Edi) In VLBW Preterm Infants overallStatus: RECRUITING date: 2021-08-21 date: 2025-12-31 date: 2026-12-31 date: 2024-03-06 date: 2024-03-06 name: Sunnybrook Health Sciences Centre class: OTHER briefSummary: Background:
In premature babies, many organ systems are not fully grown and developed, including the lungs and respiratory muscles, so they will need breathing support to help them to breathe by preventing their tiny air sacs to collapse. This support commonly done by CPAP and Non-Invasive Positive Pressure Ventilation (NIPPV) therapy by giving some pressure and oxygen to their lungs through an interface placed on their noses. Both (CPAP and NIPPV) can be used as a support modality for respiratory distress syndrome, apnea of prematurity, and providing breathing support after extubation from the full mechanical breathing support.
The CPAP supports the baby's immature lungs by delivering constant pressure to keep their lungs and breathing well supported. Whereas the NIPPV will use constant pressure in the background (similar to CPAP), and on top, it will give extra intermittent puffs at regular intervals to support the baby's breathing. The NIPPV is the most common choice by the clinicians when the traditional CPAP is no longer effective, to avoid the full mechanical breathing support and to protect the developing lungs.
Studies suggested that NIPPV is better than the traditional CPAP in reducing the need of the baby to need full mechanical breathing support. This might be because the investigators tend to use lower pressures with CPAP (5-8 cmH2O) compared to relatively higher pressures with NIPPV. More recently, clinicians showed the safety of using equivalent higher CPAP pressures (\>9 cmH2O) to what the investigators use in the NIPPV in preterm babies.
One way to measure the support that the investigators are giving to the patient with the different devices is to measure the diaphragm activity, which the investigators call the Edi signal, using a special feeding catheter and a specific machine to measure it. The catheter is placed and used as a routine feeding tube but has sensors at the end to measure this Edi signal. One opening of the tube will be connected to a computer to record the Edi signals. The other opening of the tube will be used for feeding. conditions: Preterm Birth conditions: Premature Lungs conditions: Respiratory Distress Syndrome in Premature Infant studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: The baby will be assigned to first go on traditional CPAP, NIPPV, or high CPAP, stay for 2 hours, switch to one of the other methods for 2 hours and then spend 2 hours supported by the remaining method. We will continue to record the Edi signals during the 3 methods.
Routine monitoring for oxygen saturation, heart rate, and respiratory rate will be continued as per the standard of practice in the NICU. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 24 type: ESTIMATED name: Alternating traditional CPAP, NIPPV, and high CPAP measure: The differences in Electrical Activity of the Diaphragm measured in MicroVoltage (Edi minimum) between: 1. Traditional CPAP versus NIPPV. 2. NIPPV versus CPAP (equivalent pressures in cmH2O). measure: 1. Neural respiratory rate per minute measure: 2. Edi peak measured in MicroVoltage measure: 3. The difference in transcutaneous pCO2 in mmHg measure: 4. The difference in oxygen requirements in percent (i.e, 21%) sex: ALL minimumAge: 1 Day maximumAge: 8 Months stdAges: CHILD facility: Sunnybrook Health Sciences Center status: RECRUITING city: Toronto state: Ontario zip: M4N 3M5 country: Canada name: Maher Shahroor, MD role: CONTACT phone: (416) 480-6100 phoneExt: 687939 email: maher.shahroor@sunnybrook.ca lat: 43.70011 lon: -79.4163 hasResults: False
nctId: NCT06295471 id: 2024P000112 briefTitle: A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-08 date: 2024-08 date: 2024-03-06 date: 2024-03-06 name: Massachusetts General Hospital class: OTHER briefSummary: This research study aims assess whether the Difference Frequency Generation (DFG) laser could be a better alternative to the CO2 laser in terms of reduced side effects and patient downtime. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 23 type: ESTIMATED name: DFG Laser name: CO2 Laser name: Optical coherence tomography (OCT) measure: Visual Analog Scale (VAS) pain score measure: Wound healing time measure: Vessel density via OCT imaging measure: Vessel length via OCT imaging measure: Vessel thickness via OCT imaging sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: MGH Clinical Unit for Research Trials & Outcomes in Skin city: Boston state: Massachusetts zip: 02114 country: United States name: Alicia Van Cott, MSN role: CONTACT phone: 617-726-4454 email: avancott@mgb.org name: Abigail Carlson, BS role: CONTACT phone: 617-726-4454 email: acarlson9@mgh.harvard.edu lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06295458 id: STUDY00006945 briefTitle: Gamma Sensory Flicker for Parkinson's Disease Patients With Freezing of Gait acronym: Flicker w FOG overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-06 date: 2025-06 date: 2024-03-06 date: 2024-03-06 name: Emory University class: OTHER name: Parkinson's Foundation briefSummary: The purpose of the study is to examine the safety of special eyewear and earphones that emit a visual and auditory stimulus in the gamma range (gamma flicker) in patients with Parkinson's disease for 1 hour per day and to assess the effects this stimulus has on reducing a walking problem referred to as freezing of gait (FOG) as well as on a specific spinal fluid chemical marker, amyloid.
Parkinson's disease (PD) patients often experience a complex gait disorder known as Freezing of Gait (FOG). FOG is characterized by brief arrests of stepping when initiating gait, turning, and walking straight and patients describe it as their feet being "glued" to the floor. FOG in Parkinson's disease (PD) is a considerable public health burden worldwide. It is a poorly understood gait symptom that has potentially grave consequences as FOG is intermittent and unpredictable in nature, a leading cause of falls with injury, and results in loss of independence.
FOG is generally found to be associated with cognitive decline, particularly executive dysfunction which, in turn, has been associated with higher spinal fluid amyloid (Aβ42) levels in PD. conditions: Gait Disorders, Neurologic conditions: Parkinson Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 28 type: ESTIMATED name: GammaSense Stimulation System name: Control Group measure: Number of participants with Adverse events measure: Number of participants compliant with the study procedures measure: Change in the MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) scale in participants with PD measure: Change in the freezing of gait severity in participants with PD. measure: Change in subjective changes in FOG. measure: Change in the effects of driving gamma on cerebrospinal fluid (CSF) amyloid levels in patients with PD-FOG measure: Change in the effects of driving gamma on cerebrospinal fluid (CSF) inflammatory markers levels in patients with PD-FOG sex: ALL minimumAge: 50 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Emory Movement Disorders Center city: Atlanta state: Georgia zip: 30329 country: United States lat: 33.749 lon: -84.38798 hasResults: False
nctId: NCT06295445 id: Cardiopulmonary Ultrasound briefTitle: Impact of Integrated Cardiopulmonary Ultrasound on Clinical Outcome of Shocked Patients in Intensive Care Unit overallStatus: COMPLETED date: 2022-03-01 date: 2023-09-01 date: 2023-09-15 date: 2024-03-06 date: 2024-03-12 name: Egymedicalpedia class: INDUSTRY briefSummary: Shock is one of the most common conditions in the intensive care unit (ICU) affecting one-third of critically ill patients. It reduces oxygen and nutrition's perfusion to the solid organs and is closely associated with increased mortality. Most literature has described how hemodynamic monitoring could provide an effective way to identify underlying pathophysiological processes and guide appropriate therapy in shock patients. conditions: Shock studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 108 type: ACTUAL name: care cardio-pulmonary ultrasound name: treatment without any use of point of care cardio-pulmonary ultrasound scans for guidance of the management measure: Mortality rate measure: Number of mortalities sex: ALL minimumAge: 19 Years maximumAge: 50 Years stdAges: ADULT facility: Al-Azhar University hospitals city: Cairo country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06295432 id: DZ2022E0001 briefTitle: A Phase II Clinical Trial of DZD9008 in Combination With AZD4205 in Standard Treatment Failed NSCLC Patients With EGFR Mutations (WU-KONG21) overallStatus: RECRUITING date: 2023-06-01 date: 2025-06 date: 2025-06 date: 2024-03-06 date: 2024-03-20 name: Dizal Pharmaceuticals class: INDUSTRY briefSummary: DZD9008 in combination with AZD4205 for the treatment of patients with advanced NSCLC with EGFR mutations who have progressed after standard treatment. The purpose of this study is to assess the safety and efficacy of this combination therapy. conditions: Non-small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 90 type: ESTIMATED name: DZD9008+AZD4205 measure: Part A: incidence of DLT , ≥grade 3 TEAEs and SAEs; Part B: incidence of ≥grade 3 TEAEs as assessed by CTCAE, incidence of SAEs. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Guangdong Provincial People'S Hospital status: RECRUITING city: Guangzhou state: Guangdong zip: 510000 country: China name: Zhen Wang role: CONTACT phone: 020-83827812 email: wangzhen@gdph.org.cn lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06295419 id: Igdir182 briefTitle: The Effect of Dual Task on Manual Ability Performance in Children With Cerebral Palsy overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-07-01 date: 2024-08-01 date: 2024-03-06 date: 2024-03-08 name: Igdir University class: OTHER briefSummary: The aim of the study is to investigate the effect of dual task conditions on manual dexterity performance in young people and children with CP between the ages of 7-18 and to compare it with their peers.
As a result of this study, the changes in manual dexterity and cognitive performance in dual-task conditions in children and adolescents with CP will be revealed. Additionally, changes in this performance in dual-task situations will be compared with a control group of typically developing children. conditions: Cerebral Palsy studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 60 type: ESTIMATED name: dual task name: single task measure: Abilhand Kids measure: cognitive task (single task) measure: motor performance of manual skills (writing a paragraph) (single task) measure: motor performance of manual skills (single task) measure: motor performance of manual skills (dual task) measure: motor performance of manual skills (writing a paragraph) (dual task) measure: The Body Control Measurement Scale sex: ALL minimumAge: 7 Years maximumAge: 15 Years stdAges: CHILD hasResults: False
nctId: NCT06295406 id: 21C310 briefTitle: Reading Ability in Childhood Obesity acronym: Lettura_evOB overallStatus: RECRUITING date: 2023-12-01 date: 2025-11-30 date: 2025-11-30 date: 2024-03-06 date: 2024-03-08 name: Istituto Auxologico Italiano class: OTHER briefSummary: There is some evidence about the negative impact of overweight and obesity on reading ability, with negative consequences on quality of life and school success.
In this neuropsychological research, the relationship between the characteristics of reading abilities in individuals with obesity (age range between 11 and 16 years) and the skills of motor coordination, postural stability, manual dexterity, including graphomotor skills, and estimation of time is investigated according to the cerebellar deficit theory. conditions: Obesity, Childhood conditions: Obesity, Adolescent studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 64 type: ESTIMATED name: Neuropsychological assessment measure: Raw score at the neuropsychological assessment sex: ALL minimumAge: 11 Years maximumAge: 16 Years stdAges: CHILD facility: IRCCS Istituto Auxologico Italiano - Ospedale San Giuseppe status: RECRUITING city: Piancavallo state: VCO zip: 28824 country: Italy name: Federica Scarpina, PhD role: CONTACT phone: +39032351 phoneExt: 4003 email: f.scarpina@auxologico.it hasResults: False
nctId: NCT06295393 id: 20-0229-CCMC briefTitle: Renin Angiotensin Aldosterone System In Septic Kids acronym: RISK overallStatus: RECRUITING date: 2024-01-24 date: 2025-06-01 date: 2025-06-01 date: 2024-03-06 date: 2024-03-06 name: Northwell Health class: OTHER briefSummary: Prospective observational cohort study; pediatric sepsis vs. healthy pediatric subjects and pediatric sepsis with acute kidney injury (AKI) vs without AKI.
Enzyme-linked immunosorbent assays (ELISA) with be run on serum plasma to compare the renin-angiotensin-aldosterone system (RAAS) between groups. conditions: Sepsis conditions: Acute Kidney Injury Due to Sepsis conditions: Acute Kidney Injury (Nontraumatic) studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 74 type: ESTIMATED measure: Difference in serum renin in sepsis measure: Aberrations in the renin angiotensin aldosterone system (RAAS) in sepsis associated acute kidney injury measure: Septic induced kidney injury will be associated with alterations in renal blood flow measure: Aberrations in the renin angiotensin aldosterone system (RAAS) in sepsis versus healthy patients measure: Changes in the components of the RAAS over the first three days in sepsis measure: Changes in renal blood flow on Ultrasound in Sepsis measure: Renal blood flow and RAAS in sepsis sex: ALL minimumAge: 1 Day maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Cohen Children's Medical Center status: RECRUITING city: New Hyde Park state: New York zip: 11004 country: United States name: Grace Fisler, MD role: CONTACT email: gfisler@northwell.edu name: Shannon A Moriarty role: CONTACT phone: 631-834-0984 email: smoriarty2@northwell.edu lat: 40.7351 lon: -73.68791 hasResults: False
nctId: NCT06295380 id: CarenAmp briefTitle: Virtual Reality Rehabilitation to Promote Motor Recovery in Amputees overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-09 date: 2025-03 date: 2024-03-06 date: 2024-03-06 name: IRCCS Centro Neurolesi "Bonino-Pulejo" class: OTHER briefSummary: Interventional, non-pharmacological crossover study aimed at identify statistically significant differences in postural stability and spatio-temporal gait cycle parameters in patients with lower limb amputation by means of taskoriented rehabilitation training and multisensory feedback generated by an immersive RV environment, aiming at the enhancement of use-dependent brain plasticity. These changes will be compared between the two groups examined, respectively experimental (Caren virtual training phase plus conventional physiotherapy phase) and control (conventional physiotherapy phase plus Caren virtual training phase). conditions: Lower Limb Amputation Knee conditions: Injuries conditions: Biomechanical Lesion studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 24 type: ESTIMATED name: Virtual environment practiced on the Caren name: Conventional physiotherapy measure: Kinematic data measure: Kinetic data measure: Electromyography sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Centro Neurolesi city: Messina state: Sicily zip: 98124 country: Italy name: Rocco Salvatore Calabrò, MD role: CONTACT phone: 09060128179 phoneExt: +39 email: roccos.calabro@irccsme.it lat: 38.19394 lon: 15.55256 hasResults: False
nctId: NCT06295354 id: 2024-17062 briefTitle: Early Variations in Immune Aging acronym: EVIA-NL overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2028-12 date: 2028-12 date: 2024-03-06 date: 2024-03-06 name: Radboud University Medical Center class: OTHER briefSummary: Background:
Despite an increase in lifespan over the last decades, our healthspan lags behind. In our aging population, it is pressing that we prevent age-related morbidities and associated burden on the health care system. Instead of investigating aging in already aged populations, the currently proposed study aims to elucidate the process of immune aging in relation to biological aging, demographic and lifestyle factors in young and midlife adults, and to identify early biomarkers and pathways associated with fast versus slow immune aging and aging endotypes.
A single-center, observational prospective cohort study in the Netherlands. Participants from priorly established cohorts will be invited to join the EVIA-study. We will obtain demographic and basic clinical data and biological samples (blood and stool) at baseline and after three years, with a short, yearly online questionnaire in between. conditions: Aging conditions: Aging Well conditions: Immuno Aging studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: No intervention, we just study 'aging' measure: Immunological function measure: Immunological Aging Score measure: Biological Aging Score measure: Metagenomics measure: Genetics and epigenetics measure: Clinical events sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT hasResults: False