hackint0sh/New-Dataset huggingface dataset:
RESULTS AND CONCLUSION: To clarify the intervention effect of ACT combined with yoga intervention program on parenting burnout of ASD parents. conditions: Autism Spectrum Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: Acceptance commitment therapy and yoga name: Active Comparator: Mental Health Education Group measure: Measuring parental Burnout Levels measure: Measuring parenting stress Levels measure: Patient-Reported Outcomes Measurement Information System adult profile-57, PROMIS-57 measure: Medical Outcomes Study 36-Item Short-Form Health Survey, MOS SF-36 measure: Acceptance and Action Questionnaire-II, AAQ-II measure: Cognitive Fusion Questionnaire，CFQ-F sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Harbin Medical University Hospital status: RECRUITING city: Daqing state: None Selected zip: 043300 country: China name: Jiayi Chen, Master role: CONTACT phone: 15765962070 email: cjy071949@163.com lat: 46.58333 lon: 125.0 hasResults: False
nctId: NCT06348979 id: CEBD 5/2021 briefTitle: Clinical Performance of Fiber Reinforced FRC Base and Bonded CAD/CAM Resin Composite Endocrowns overallStatus: COMPLETED date: 2022-01-01 date: 2023-12-30 date: 2024-01-30 date: 2024-04-05 date: 2024-04-05 name: Cairo University class: OTHER briefSummary: This research proposal is introduced to clinically test short fiber reinforced flowable resin composite material (everX Flow, GC Europe) as a supporting base under CAD/CAM resin composite endocrowns due to gap of knowledge present in this area. conditions: Dental Caries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 110 type: ACTUAL name: Fiber flowable (SFRC) support below hybrid nanoceramic endocrowns name: all ceramic Endocrowns (emax) measure: clinical Fracture measure: clinical performance marginal adaptation sex: ALL minimumAge: 18 Years maximumAge: 38 Years stdAges: ADULT facility: Cairo University city: Cairo country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06348966 id: predictors of readmission briefTitle: Predictors of Hospital Readmission for Chronic Obstructive Pulmonary Disease Patients overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05 date: 2026-06 date: 2024-04-05 date: 2024-04-05 name: Assiut University class: OTHER briefSummary: This study is aimed to determine the risk factors for hospital readmission within 6 months in COPD patients conditions: Hospital Radmission for COPD Patients studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 188 type: ESTIMATED measure: assessment of potential predictors of readmission among COPD patients measure: development of early warning model for hospital readmission in COPD patients sex: ALL minimumAge: 25 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06348953 id: Bioactive restorative system briefTitle: Bioactive Versus Non-Bioactive Restorative System in Deep Carious Molars overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-11 date: 2025-11 date: 2024-04-05 date: 2024-04-09 name: Cairo University class: OTHER briefSummary: This research study delves into the effectiveness of bioactive and non-bioactive restorative systems in deep carious permanent molars treated with selective caries removal. Selective caries removal techniques aim to preserve as much healthy tooth structure as possible while effectively eliminating carious tissue. The study investigates how the choice of restorative material influences the outcomes of selective caries removal procedures in deep carious lesions. By assessing factors such as restoration integrity, pulpal response, and long-term success rates, the research seeks to provide evidence-based insights into the comparative performance of bioactive and non-bioactive restorative systems in this clinical context. conditions: Dental Caries conditions: Dental Diseases conditions: Deep Caries conditions: Tooth Diseases conditions: Tooth Decay conditions: Teeth; Lesion conditions: Caries; Dentin conditions: Dental Restoration Failure of Marginal Integrity conditions: Tooth Demineralization studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: selective caries removal and conventional non-bioactive restorative system name: selective caries removal and bioactive restorative system measure: Biological properties - Post Operative Hypersensitivity and Vitality-Success rate%-Scoring system:Ordinal1-5 measure: Functional properties - fracture&retention-marginal adaptation-Radiographic Examination"when applicable"-Scoring system Ordinal 1-5 measure: Biological properties (Recurrence of caries (CAR), erosion, abfraction- Scoring system Ordinal 1-5) measure: Success or Failure sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT hasResults: False
nctId: NCT06348940 id: 83242392 briefTitle: Effects of Behavioral Activation on Negative Emotions, Cancer-related Symptoms and Clinical Indicators in Cancer Patients overallStatus: ACTIVE_NOT_RECRUITING date: 2023-03-12 date: 2024-06-12 date: 2024-06-12 date: 2024-04-05 date: 2024-04-08 name: Anhui Medical University class: OTHER briefSummary: The majority of cancer patients experience varying degrees of psychological distress and physical symptoms due to the presence of cancer or the process of treatment. These symptoms are closely associated with inflammatory markers and patient prognosis, highlighting the urgent need for effective psychological intervention methods. Behavioral activation, an emerging psychological intervention approach, requires further investigation regarding its potential in alleviating negative emotions among cancer patients. Therefore, the investigators conducted a randomized controlled trial (RCT) to investigate whether (1) behavioral activation can ameliorate negative emotions and physical symptoms in cancer patients; (2) behavioral activation can contribute to improved survival outcomes for these patients; and (3) behavioral activation can enhance NLR levels and other clinical indicators among individuals with cancer.
The investigators aimed to recruit a total of 390 cancer patients, comprising 170 individuals diagnosed with esophageal and gastric cancer, 100 individuals with colorectal cancer, and 120 individuals with lung cancer. These patients were recruited from the Department of Oncology at the Second Affiliated Hospital of Anhui Medical University between March 2023 and November 2023. They were randomly allocated into two groups: an intervention group (behavioral activation+care as usual, BA+CAU) and a control group (care as usual, CAU). The intervention group underwent an eight-week behavioral activation program (see Detailed Description) designed to promote engagement in meaningful activities that are physically and emotionally rewarding while reducing involvement in maladaptive emotional cycles. Both the intervention group and the control group received standard care along with conventional treatment for their respective cancers.
This study aims to demonstrate the significant efficacy of behavioral activation in improving negative emotions, somatic symptoms, quality of life, and clinical inflammatory indicators among cancer patients. Furthermore, it may potentially enhance patient survival rates, thereby offering a novel approach for psychological intervention in cancer patients and contributing to multidisciplinary treatment and management strategies. The intervention measures employed in this study do not involve any pharmacological treatments or hazardous activities. For illiterate or less educated patients, the informed consent process and questionnaire collection will be conducted using methods that ensure their full comprehension (e.g., verbal explanations, visual aids). Additionally, patients with evident cognitive impairments were excluded from the study.
The investigators have implemented a questionnaire system on the WJX website (https://www.wjx.cn/) to collect patient information through both paper and electronic questionnaires. The psychological measurement questionnaires are stored electronically, while socio-demographic data and clinical indicators are collected in the hospital's medical record management system. Subsequently, all data is summarized and saved in local Excel files and SPSS files for specialized analysis by data analysts. Patient names are anonymized within the database, ensuring strict confidentiality of personal information such as contact details and home address.
Possible statistical methods include descriptive statistical analysis, generalized estimating equation or repeated measures analysis of variance, structural equation modeling, correlation analysis and regression, survival analysis, etc. conditions: Cancer Patients studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 390 type: ESTIMATED name: behavioral activation measure: Sociodemographic data measure: Status of Tumor measure: Body Mass Index, BMI measure: Biochemical index measure: Blood Pressure, BP measure: Nutritional Risk Screening, NRS measure: Visual Analogue Scale, VAS measure: Karnofsky Performance Status Scale, KPS measure: Psychological Distress Thermometer (DT) measure: Hospital anxiety and depression scale (HADS) measure: European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) measure: Pittsburgh sleep quality index (PSQI) measure: Revised Piper Fatigue Scale (PFS-R) measure: International physical activity questionnaire (IPAQ) measure: Brief Resilient Coping Scale (BRCS) measure: Multidimensional Scale of Perceived Social Support (MSPSS) measure: General Self-Efficacy Scale (GSES) measure: The activation subscale of Behavioral Activation for Depression Scale (BADS-A) measure: Social Impact Scale (SIS) measure: Fear of Cancer Recurrence Inventory- Short Form (FCRI-SF) measure: The Functional Assessment of Cancer Therapy-Cognitive (FACT-Cog) measure: Time of Progression-free survival (PFS) measure: Time of Time to progression (TTP) measure: Concentration of C-reactive protein (CRP) measure: Value of Neutrophils to lymphocytes ratio (NLR) measure: Value of Platelet-lymphocyte ratio (PLR) measure: Value of Monocyte-lymphocyte ratio (MLR) measure: Value of Systemic immune inflammation index (SII) measure: Value of Pan-immune inflammation value (PIV) measure: Concentration of Carcinoembryonic antigen (CEA) measure: Concentration of Carbohydrate antigen 19-9 (CA19-9) measure: Concentration of Carbohydrate antigen 72-4 (CA72-4) measure: Concentration of Neuron-specific enolase (NSE) measure: Concentration of Squamous cell carcinoma associated antigen (SCC) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Second Affiliated Hospital of Anhui Medical University city: Hefei state: Anhui country: China lat: 31.86389 lon: 117.28083 hasResults: False
nctId: NCT06348927 id: DZ2023EI004 briefTitle: Sunvozertinib Plus Anlotinib as 1L Treatment in EGFR-Sensitive Mutations Combined With Co-Mutations Advanced NSCLC acronym: WUKONG-32 overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2025-10-31 date: 2027-04-30 date: 2024-04-05 date: 2024-04-05 name: Hunan Province Tumor Hospital class: OTHER briefSummary: This is a phase II, open-label, single-arm, single-center clinical study to evaluate the preliminary efficacy of sunvozertinib in combination with anlotinib in patients with EGFR-sensitive mutations and co-mutations in locally advanced or metastatic treatment-naive non-small cell lung cancer.
Condition or disease Intervention/treatment Phase Non-Small Cell Lung Cancer Drug: sunvozertinib Drug: anlotinib Phase 2 conditions: Non-Small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 52 type: ESTIMATED name: sunvozertinib in combination with Anlotinib measure: Progression-free survival (PFS) measure: Objective Response Rate (ORR) measure: Overall survival (OS) measure: Duration of Response (DoR) measure: Adverse events (AEs) according to CTCAE 5.0 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hunan Cancer Hospital city: Changsha state: Hunan zip: 410013 country: China lat: 28.19874 lon: 112.97087 hasResults: False
nctId: NCT06348914 id: 6991 briefTitle: Knowledge of Vital Pulp Therapy in Permanent Teeth Among a Group of Dental Students in Egypt overallStatus: NOT_YET_RECRUITING date: 2024-09-10 date: 2024-11-10 date: 2024-12-30 date: 2024-04-05 date: 2024-04-05 name: Cairo University class: OTHER briefSummary: Conducting this questionnaire will help in collecting information about the extent of knowledge of vital pulp therapy in permanent teeth among dental students in Egypt. This will aid in identifying the knowledge gap, interest, and challenges regarding utilization of vital pulp therapy in permanent teeth. conditions: Vital Pulp Therapy studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: CROSS_SECTIONAL count: 323 type: ESTIMATED name: Knowledge assessment name: Educational Material measure: Knowledge of vital pulp therapy measure: Knowledge after awareness about vital pulp therapy sex: ALL minimumAge: 15 Years maximumAge: 25 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06348901 id: 2021-09-001 briefTitle: Clinical Utility of Oxford Cognitive Screen Test to Screen Cognitive Impairment in Post Stroke Patients overallStatus: RECRUITING date: 2021-09-01 date: 2025-02-28 date: 2025-02-28 date: 2024-04-05 date: 2024-04-05 name: Bundang CHA Hospital class: OTHER briefSummary: The goal of this type of study: clinical trial is to assess K-OCS clinical utility in participant population. The main aims:
validate the reliability and validity of the Korean version of the Oxford Cognitive Screen (K-OCS) analyze its sensitivity, specificity, and diagnostic accuracy, and compare its examination participation rates with existing assessment tools to determine the effectiveness of K-OCS in detecting post-stroke cognitive impairment. conditions: Stroke studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED measure: Measurement of K-OCS measure: Measurement of Korean version of mini-mental state examination (K-MMSE) measure: Measurement Korean Version of the Oxford cognitive screen (K-OCS) measure: Measurement of national institute of health care stroke scale (NIHSS) measure: Measurement of fuctional independence meausure (FIM) sex: ALL minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Rehabilitation Medicine, CHA Bundang Medical Center status: RECRUITING city: Seongnam-si state: Gyeonggi-do zip: 13496 country: Korea, Republic of name: Eunyoung Cho role: CONTACT phone: +82-10-2753-0285 email: a220242@chamc.co.kr lat: 37.43861 lon: 127.13778 hasResults: False
nctId: NCT06348888 id: 22250 briefTitle: A Study to Learn About How Itraconazole and Carbamazepine Affect the Level of BAY2927088 in the Blood When These Drugs Are Taken Together by Healthy Participants overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-05-30 date: 2024-05-30 date: 2024-04-05 date: 2024-04-05 name: Bayer class: INDUSTRY briefSummary: Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called EGFR and HER2 mutations.
BAY2927088 is broken down by an enzyme called CYP3A4 inside the body. Itraconazole is a drug that inhibits the activity of CYP3A4 while carbamazepine is a drug that enhances the activity of CYP3A4. Giving these drugs together will allow researchers to learn how the blood levels of BAY2927088 change when the CYP3A4 activity is inhibited or enhanced.
* ask the participants questions about how they are feeling and what adverse events they are having An adverse event is any medical problem that a participant has during a study. The study doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatment. conditions: Advanced Non-small Cell Lung Cancer conditions: EGFR Mutation conditions: HER2 Mutation conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: NONE count: 30 type: ESTIMATED name: BAY2927088 name: Itraconazole name: Carbamazepine measure: AUC of BAY2927088 with and without itraconazole measure: Cmax of BAY2927088 with and without itraconazole measure: AUC of BAY2927088 with and without carbamazepine measure: Cmax of BAY2927088 with and without carbamazepine measure: Number of participants with TEAEs measure: Severity of TEAEs sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT hasResults: False
nctId: NCT06348875 id: CLN-PLAN-102v1 briefTitle: Clinical Evaluation of Radiation Reduction for Optimized Safety acronym: CERROS overallStatus: NOT_YET_RECRUITING date: 2024-06-15 date: 2024-07-15 date: 2024-07-31 date: 2024-04-05 date: 2024-04-05 name: Angiowave Imaging class: INDUSTRY briefSummary: The primary objective of this study is to determine whether a reduced radiation protocol (RRP) in which angiograms are acquired at ultralow radiation doses and then processed using spatiotemporal enhancement software can produce similar quality angiographic images as compared with standard techniques. conditions: Coronary Artery Disease conditions: Myocardial Infarction conditions: Coronary Disease conditions: Coronary Stenosis conditions: Angina Pectoris conditions: Chest Pain studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED measure: Segment-level percent diameter stenosis (%DS) measure: Stenosis severity measure: Diagnostic quality measure: Radiation dose - SOC sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Corewell Health West city: Grand Rapids state: Michigan zip: 49503 country: United States name: Ryan Madder, MD role: CONTACT phone: 616-391-4327 email: Ryan.Madder@corewellhealth.org name: Timothy Joseph, MD role: CONTACT phone: 616-391-4327 email: stacie.vanoosterhout@corewellhealth.org name: Ryan Madder, MD role: PRINCIPAL_INVESTIGATOR name: Timothy Joseph, MD role: PRINCIPAL_INVESTIGATOR lat: 42.96336 lon: -85.66809 hasResults: False
nctId: NCT06348862 id: 323/REC/2023 briefTitle: Assessment of Stress and Anxiety for Patients Undergoing MRI Using, Holy Quran, Music, and Natural Sounds overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2024-06-30 date: 2024-06-30 date: 2024-04-05 date: 2024-04-05 name: Al-Quds University class: OTHER briefSummary: The aim of the current study is to analyze the effect of listening to Quran or music or natural sounds on anxiety and stress level among patients undergoing MRI. conditions: Anxiety conditions: Stress conditions: MRI Contrast Media Adverse Reaction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: Double blinded whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 400 type: ESTIMATED name: Listening to either Quran, Music, and or Natural sound measure: Level of Anxiety among patients who underwent MRI measure: Level of Stress measure: Sociodemographic sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06348849 id: 0797-11/2023 briefTitle: The Desensitising Effect of Nanosilver Fluoride in Molar-Incisor Hypomineralisation overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-06 date: 2024-07 date: 2024-04-05 date: 2024-04-05 name: Alexandria University class: OTHER briefSummary: The aim of the current study is to assess the desensitising effect of nanosilver fluoride on first permanent molars (FPMs) in patients with MIH in comparison to low-level laser therapy. conditions: Molar Incisor Hypomineralization conditions: Hypersensitivity studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED measure: Desensitising effect in hypersensitive MIH molars measure: Change in the plaque index scores measure: Change in children's frequency of toothbrushing sex: ALL minimumAge: 7 Years maximumAge: 10 Years stdAges: CHILD hasResults: False
nctId: NCT06348836 id: 2123624-1/2 briefTitle: The Effects of Open Chain Versus Closed Chain Strengthening on Dynamic Valgus During a Step Down Test overallStatus: RECRUITING date: 2024-03-22 date: 2025-02-28 date: 2025-02-28 date: 2024-04-05 date: 2024-04-05 name: Alvernia University class: OTHER briefSummary: The goal of this clinical trial is to compare the effects of different exercises programs in individuals with abnormal knee motion. The main question it aims to answer are:
* Further motion analysis and EMG data will be collected to test for differences. Researchers will compare individual results before and after exercise, and between-group results before and after exercise to see if one exercise program helps improved abnormal knee motion more than the other. conditions: Dynamic Knee Valgus studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants will be randomly assigned to either a closed-chain (weightbearing) exercise group or an open-chain (non-weightbearing) exercise group primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: Exercise measure: Electromyographic activity of gluteus medius muscle during step-down test measure: Electromyographic activity of quadriceps muscle during step-down test measure: Electromyographic activity of hamstring muscles during step-down test measure: Amount of dynamic knee valgus during step-down test measured with motion analysis sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Alvernia University status: RECRUITING city: Reading state: Pennsylvania zip: 19607 country: United States name: James M O'Donohue, DPT role: CONTACT phone: 610-334-1162 email: jim@odfamily.com lat: 40.33565 lon: -75.92687 hasResults: False