hackint0sh/New-Dataset huggingface dataset:
The experimental group started using the app for 15 days, and later completed the following assessment (T2). The control group also completed the T2 in the same date but started to use the app after this second assessment.15 days and one month later, both groups completed T3 and T4. primaryPurpose: PREVENTION masking: SINGLE whoMasked: PARTICIPANT count: 100 type: ESTIMATED name: GGON mobile app. measure: Change in the degree of ascription to dysfunctional beliefs associated with Orthorexia Nervosa measure: Change in Orthorexia symptomatology measure: Change in eating symptomatology measure: Change in self-esteem. measure: Change in emotional symptomatology measure: Change in obsessive beliefs sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Valencia city: Valencia zip: 46010 country: Spain lat: 39.46975 lon: -0.37739 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2022-04-18 uploadDate: 2024-03-11T04:30 filename: ICF_000.pdf size: 79708 hasResults: False
nctId: NCT06288334 id: PUTH PD_V 1.2 briefTitle: Exploration of the Optimal Dosage of Cetirizine in the Treatment of Allergic Diseases in Chinese Children overallStatus: RECRUITING date: 2020-08-06 date: 2024-03-31 date: 2024-05-31 date: 2024-03-01 date: 2024-03-01 name: Peking University Third Hospital class: OTHER briefSummary: To obtain the pharmacokinetics of cetirizine in Chinese children with allergic disease. conditions: Allergic Disease conditions: Children studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 80 type: ESTIMATED name: 1-3 Cetirizine Pharmacokinetic samples measure: Plasma concentration sex: ALL minimumAge: 6 Months maximumAge: 16 Years stdAges: CHILD facility: Peking University Third Hospital status: RECRUITING city: Beijing state: Beijing zip: 100191 country: China name: Yafen Li role: CONTACT phone: 18222566785 email: liyafen314159@163.com name: Wei Zhou role: PRINCIPAL_INVESTIGATOR name: Wei Liu role: PRINCIPAL_INVESTIGATOR name: Dongyang Liu role: PRINCIPAL_INVESTIGATOR lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06288321 id: UW22221 briefTitle: A Study Investigating Whether Low Dose Eyedrops for Pupil Dilation is as Effective and Safe as Standard Dose Eyedrops in Examination for Retinopathy of Prematurity. overallStatus: COMPLETED date: 2022-08-10 date: 2023-03-22 date: 2023-03-22 date: 2024-03-01 date: 2024-03-01 name: The University of Hong Kong class: OTHER briefSummary: A prospective, randomized controlled study was conducted from August, 2022 to March, 2023 in the neonatal intensive care unit in Queen Mary Hospital, Hong Kong. The aim of this study was to determine whether microdrops Mydrin-P demonstrates similar efficacy as standard Mydrin -P eyedrops applied to neonates undergoing retinopathy of prematurity (ROP) screening exams, also to ascertain the optimal time for eye examination after administration of mydriatics and assess whether the cardiovascular, respiratory and gastrointestinal adverse effects differ between microdrops and standard dose Mydrin-P.
Preterm infants were randomized to receive either the standard Mydrin-P eyedrops or the mydriatic microdrops which contained around one-third of the standard Mydrin-P dosage. The primary outcome measured whether a successful ROP examination was conducted. Secondary outcomes included pupil diameters at baselines, 30 minutes, 60 minutes, 120 minutes after eyedrops instillation and at the time of ROP exam as well as adverse effects followed by the mydriatics administration.
A total of 18 patients were enrolled in this study with total 46 episodes of ROP recorded. All episodes with microdrops instillation led to successful ROP exams. There was no statistically significant difference between standard eyedrops and microdrops in determining the success of ROP exam (p=0.233). Mean pupil diameter did not differ between the microdrops and standard eyedrops group. At the time of ROP exam, the mean pupil diameter was 5.47mm in the standard eyedrops group and 5.73mm in the microdrops group. The optimal time for ROP exam was 60 minutes to 120 minutes after first dose of mydriatic. Also there was no difference in the occurrence of systemic side effects when compared to standard Mydrin P drops.
Hence the study concluded that microdrops have similar efficacy and safety profile compared to standard Mydrin-P eyedrops. conditions: Retinopathy of Prematurity studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 18 type: ACTUAL name: Microdrop Mydrin-P name: Standard Mydrin-P measure: Successfulness of a ROP exam measure: Pupil diameters measure: Heart rate measure: Blood pressure measure: Oxygen saturation measure: Oxygen requirement measure: Episodes of vomiting measure: Volume of gastric residuals measure: Episodes of apnoea measure: Episodes of periorbital blanching sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital city: Hong Kong country: Hong Kong lat: 22.27832 lon: 114.17469 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2022-07-14 uploadDate: 2024-02-18T04:50 filename: Prot_000.pdf size: 94463 hasResults: False
nctId: NCT06288308 id: FAR in lupus nephritis (LN) briefTitle: Fibrinogen to Albumin Ratio (FAR) as a Predictive Biomarker for Lupus Nephritis (LN) overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2024-11 date: 2024-12 date: 2024-03-01 date: 2024-03-01 name: Assiut University class: OTHER briefSummary: Fibrinogen to Albumin ratio as a predictive biomarker for lupus nephritis (LN) conditions: Lupus Nephritis studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 90 type: ESTIMATED name: fibronigin to albumin ratio measure: Fibrinogen to Albumin ratio as a predictive biomarker for lupus nephritis (LN) sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
nctId: NCT06288295 id: Etude SCORDOM briefTitle: Retrospective Study on Data Aiming to Establish a Prediction Score for Return Home at the Time of Admission to a Multidisciplinary Medical Department (SCORDOM acronym: SCORDOM overallStatus: COMPLETED date: 2021-10-01 date: 2023-02-28 date: 2023-02-28 date: 2024-03-01 date: 2024-03-01 name: Elsan class: OTHER briefSummary: The goal of this observational study is to define clinical, biological and socio-cultural criteria, from the very first days of hospitalization on the multidisciplinary medicine department, to guide the patient's discharge from hospital (return to home when discharged from hospital).
Participants are patients previously hospitalized. They will be informed about the study by post and will be able to object to the use of his or her data. conditions: Continuity of Patient Care studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 600 type: ACTUAL measure: Number of patients with a return to home after hospitalization and with similar clinical parameters, similar age category, similar pathology and similar biological parameters measure: Number of patients with a return to home after hospitalization and with similar clinical parameters, similar age category, similar pathology and similar biological parameters sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hôpital Privé Nancy Lorraine city: Nancy zip: 54000 country: France lat: 48.68439 lon: 6.18496 hasResults: False
nctId: NCT06288282 id: STUDY-23-01287 briefTitle: Behavioral and Cognitive Predictors of Persistent Pain and Opioid Misuse in Chronic Pain overallStatus: RECRUITING date: 2023-12-20 date: 2024-12-20 date: 2024-12-20 date: 2024-03-01 date: 2024-03-01 name: Icahn School of Medicine at Mount Sinai class: OTHER briefSummary: Chronic lower back pain (CLBP) affects approximately 20% of the global population. The study objective is to determine if impulsivity, inhibitory control, drug choice, and/or cognitive distortions predict opioid misuse and disability in patients with chronic pain. This is a prospective consented cross-sectional study characterizing behavioral and cognitive phenotypes using both patient-reported survey measures and cognitive testing. Outcome measures include correlations between impulsivity measures, opioid drug choice responses and cognitive distortion scores, and risk for opioid misuse (Primary outcomes: COMM scores, SOAPPR scores). Secondary outcomes is BPI measurement. A Certificate of Confidentiality will provide additional protections for participants. conditions: Chronic Back Pain studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 130 type: ESTIMATED name: No Intervention measure: Screener and Opioid Assessment for patients with pain revised (SOAPPR) measure: Current Opioid misuse measure (COMM) surveys measure: Pain Intensity with Brief Pain inventory (BPI) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mount Sinai Pain management centers status: RECRUITING city: New York state: New York zip: 10029 country: United States lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06288269 id: PhrapokklaoHospital briefTitle: Factors of Control Hypertension or Type 2 Diabetes on the Severity of Stroke and Survival Rates Within 1 Year in Trat overallStatus: COMPLETED date: 2023-11-01 date: 2023-12-30 date: 2024-01-15 date: 2024-03-01 date: 2024-03-07 name: Phrapokklao Hospital,Thailand class: OTHER briefSummary: The purpose of this study was to study factors for controlling hypertension or type 2 diabetes before stroke diagnosis on the severity level when a stroke occurs, NIHSS, and survival rate after having a stroke in 1 year in Trat Province The research hypothesis was patients with hypertension or type 2 diabetes who are well-controlled Will have a lower NIHSS score than the group whose disease is not well-controlled. and patients with hypertension or type 2 diabetes that is well controlled There will be a higher survival rate for patients diagnosed with cerebrovascular disease within 1 year than those whose disease cannot be controlled. conditions: Stroke conditions: Hypertension conditions: Type2diabetes studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 291 type: ACTUAL name: Severity of Stroke and 1 year survival measure: Stroke severity was assessed using the National Institute of Health Stroke Scale (Clinical Mild NIHSS = 0-4 and Clinical Moderate to severe NIHSS = 5-42) measure: 1 year survival death sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Trat Provincial Public Health Office city: Trat zip: 23000 country: Thailand lat: 12.24364 lon: 102.51514 hasResults: False
nctId: NCT06288256 id: STUDY-22-01390 briefTitle: Neurocognitive and Genomic Predictors of Persistent Pain and Opioid Misuse After Spine Surgery overallStatus: ACTIVE_NOT_RECRUITING date: 2023-03-01 date: 2024-06 date: 2024-06 date: 2024-03-01 date: 2024-03-01 name: Icahn School of Medicine at Mount Sinai class: OTHER briefSummary: Having spine surgery and recovery is a vulnerable period when opioid naive patients may transition into long-term use of opioids, and when previously opioid tolerant patients may be at risk to continue towards long-term opioid use and dependence. However, little is known about risk for developing opioid misuse, taking opioids differently than indicated or prescribed, and later OUD. This study addresses the question of whether behavior, cognitive features, and genomic markers can predict misuse of opioids, persistent pain and disability in individuals after spine surgery.
This is a prospective observational longitudinal study characterizing behavioral phenotypes in adults undergoing spine surgery using both patient-reported survey measures, cognitive testing and blood sampling. Outcome measures include correlations between impulsivity measures, opioid drug choice responses and cognitive distortion scores, and opioid misuse with spine related disability, and gene expression counts. conditions: Lumbar Spine Pathology conditions: Elective Spine Surgery studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: No Intervention measure: Current Opioid Misuse Measure (COMM) Score measure: Numerical Rating Scale (NRS) Score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mount Sinai Spine Center city: New York state: New York zip: 10029 country: United States lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06288243 id: Samatya briefTitle: Functionality, Cognition And Swallowing Skills In Patients With AcuteSTROKE overallStatus: COMPLETED date: 2018-12-01 date: 2019-05-28 date: 2019-05-29 date: 2024-03-01 date: 2024-03-01 name: Medipol University class: OTHER briefSummary: Aim: Studies in which the results of the screening test evaluating swallowing skills in acute stroke patients are evaluated together with other components that may affect swallowing function are limited. The aim of this study is to determine which factors are associated with swallowing abilities in patients with acute stroke, including lesion location, cognitive level, clinical features, risk factors for stroke, and level of functionality.
Methods: The 97 acute stroke patients included in the study were grouped in terms of lesion type, affected side, and risk factors for stroke. Turkish MMASA (TR-MMASA) was used to evaluate the swallowing ability of the patients. Additionally, Standardized Mini Mental Test (SMMT) and Modified Rankin Scale (MRS) were applied to evaluate cognition level and functionality, respectively. conditions: Stroke, Acute conditions: Swallowing Disorder conditions: Cognitive Impairment conditions: Stroke conditions: Movement Disorders conditions: Dysphagia studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 97 type: ACTUAL name: Clinician-observed assessment tests measure: The Correlation Between Swallowing Skills and Cognitive Status measure: The Correlation Between Swallowing Skills and Functionality measure: The relationship between stroke risk factors and swallowing skills measure: The relationship between demographic informations and swallowing skills sex: ALL minimumAge: 45 Years maximumAge: 92 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Medipol University city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06288230 id: LT01-101 briefTitle: An Open Label Study of Gene Therapy Product in Spinal Muscular Atrophy Patients overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2027-03-01 date: 2027-03-01 date: 2024-03-01 date: 2024-03-01 name: Lantu Biopharma class: INDUSTRY briefSummary: This is an interventional study to evaluate safety and efficacy of AAV-hSMN1 in spinal muscular atrophy patients. conditions: Spinal Muscular Atrophy studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 6 type: ESTIMATED name: vesemnogene lantuparvovec measure: Numbers of participants with adverse events (AEs), serious adverse events (SAEs) measure: Change from baseline in hours of daily ventilation support and motor function measure: Change from baseline in ambulatory function measure: Change from baseline in Hammersmith Functional Motor Scale - Expanded (HFMSE) sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06288217 id: NS-CIP-001 briefTitle: Non-invasive Trigeminal and Vagus Nerve Stimulation for Stroke Subjects With Chronic Upper Extremity Deficits overallStatus: RECRUITING date: 2024-03-05 date: 2024-12 date: 2024-12 date: 2024-03-01 date: 2024-03-12 name: NeuraStasis, Inc class: INDUSTRY briefSummary: This is a single-center, pilot study of up to 25 subjects with residual upper extremity deficits at least six months after an ischemic stroke. The purpose of the study is to evaluate the initial clinical safety, device functionality, and treatment effect of non-invasive electrical stimulation of the trigeminal and/or vagus nerves (nTVNS) using the NeuraStasis Stimulator System adjunctive to rehabilitation. Subjects will either receive the intervention or control-sham stimulation. The study will inform the design and implementation of a pivotal study. conditions: Stroke, Ischemic conditions: Upper Extremity Paresis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 25 type: ESTIMATED name: NeuraStasis Stimulator System (Non-Invasive Trigeminal and Vagus Nerve Stimulation) name: Upper Limb Rehabilitation name: Sham Stimulation measure: Fugl-Meyer Assessment, Upper Limb (FMA-UE) Average Change measure: Action Research Arm Test (ARAT) Average Change measure: Fugl-Meyer Assessment, Upper Limb (FMA-UE) Response % measure: Proportion of subjects completing all pre-specified treatment doses measure: Subject Questionnaire on Device Usage measure: Therapist Questionnaire on Device Usage measure: Serious adverse device effects (SADE) rate at 24 hours post-therapy session measure: Stroke impact scale (SIS) Summative Score Average Change measure: Analysis of the number of stimulations per therapy session sex: ALL minimumAge: 40 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The University of Texas Health Science Center at Houston status: RECRUITING city: Houston state: Texas zip: 77030 country: United States name: Sean Savitz, MD role: CONTACT phone: 713-500-7083 email: Sean.I.Savitz@uth.tmc.edu name: Emily Stevens, OTR role: CONTACT phone: 713-500-7914 email: emily.a.stevens@uth.tmc.edu lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06288204 id: Denise Mafra16 briefTitle: Green Propolis Extract and Royal Jelly in Hypertensive Patients and/or With Chronic Kidney Disease overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-07-31 date: 2027-07-31 date: 2024-03-01 date: 2024-03-01 name: Universidade Federal Fluminense class: OTHER name: Conselho Nacional de Desenvolvimento Científico e Tecnológico name: Rio de Janeiro State Research Supporting Foundation (FAPERJ) name: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. briefSummary: This work aims to evaluate the effects of the association of green propolis extract with royal jelly on inflammation and oxidative stress in participants with CKD and SAH, in a longitudinal, randomized, double-blind, placebo-controlled clinical trial that will be carried out for 2 months. conditions: Chronic Kidney Diseases conditions: Hypertension conditions: Cardiovascular Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 153 type: ESTIMATED name: Propolis + Royal Jelly name: Royal Jelly name: Placebo measure: Change in inflammation, oxidative stress measure: Change in intestinal microbiota measure: Change in senescence biomarkers measure: Change in uremic toxins measure: Change in adhesion molecules measure: Change in blood pressure sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Denise Mafra city: Rio de Janeiro state: RJ zip: 22260050 country: Brazil name: Denise Mafra, phd role: CONTACT phone: 21985683003 email: dmafra30@gmail.com lat: -22.90278 lon: -43.2075 hasResults: False
nctId: NCT06288191 id: MIA2023/490 id: CA224-1065 type: OTHER domain: Bristol-Myers Squibb briefTitle: Neoadjuvant Nivolumab and Relatlimab in Cutaneous Squamous Cell Carcinoma overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-06 date: 2036-04 date: 2024-03-01 date: 2024-03-04 name: Melanoma Institute Australia class: OTHER name: Bristol-Myers Squibb briefSummary: The goal of this study is to test neoadjuvant therapy with the dual inhibition of Programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 (LAG-3) immune checkpoint pathways in a cohort of treatment-naïve, resectable stage II to IV cutaneous squamous cell carcinoma on the pathological response rate (pCR) and recurrence-free survival. conditions: Cutaneous Squamous Cell Carcinoma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Open label, single arm, single centre, clinical trial primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Nivolumab 240 mg / Relatlimab 80 mg in a fixed dose combination measure: Pathological complete response rate measure: Pathological near pathological response (near pCR), partial response (pPR) and pathological non-response (pNR) rate measure: Toxicity and tolerability of neoadjuvant immunotherapy and surgery measure: Objective response rate to neoadjuvant therapy measure: Metabolic response rate to neoadjuvant immunotherapy measure: Recurrence-free survival measure: Disease progression rate measure: Event-free survival rate measure: Overall survival measure: Patient reported quality of life (QLQ-C30) measure: Patient reported quality of life (EQ-5L-5D) measure: Study treatment completion rate and the causes of any missed treatments measure: De-escalation of adjuvant radiotherapy. measure: Identification of tissue and blood biomarkers of response / resistance measure: Profile of the gut microbiome from faecal samples and relationship to response and toxicities. measure: The pathological response to RECIST, immune related response criteria and PERCIST response measure: Assessment of the response to neoadjuvant using the immune-related response criteria (irRC) and correlate the assessment with the RECIST 1.1 response at each timepoint sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06288178 id: 2022/18 briefTitle: The Effect of Consumption of Bread Types Made From Various Flours on Blood Glucose Fluctuations acronym: Obesity overallStatus: COMPLETED date: 2022-12-19 date: 2023-01-20 date: 2023-02-20 date: 2024-03-01 date: 2024-03-01 name: Ege University class: OTHER briefSummary: The obesities were aimed at the effect of whole wheat (WWB), buckwheat (BWB), and cornbread (CB) on blood glucose by comparing the glycemic index values with reference bread (RB).
Overall, WWB consumption had a positive effect on blood glucose in individuals with obesity, while BWB consumption caused an increase in blood glucose levels. conditions: Obesity conditions: Glycemic Index conditions: Blood Glucose conditions: Bread studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: PARTICIPANT count: 103 type: ACTUAL name: Bread consumption measure: One loaf of bread was been consumed every week. Blood glucose measurements were performed with a glucometer at 0 (fasting), 30, 60, 90, and 120 minutes after each bread consumption. measure: This classification as obese and normal-weight individuals was made with the BIA (Bioelectrical impedance analysis) method. This classification was understood by anthropometric measurements made in the first week. sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Avrasya University city: Trabzon zip: 61000 country: Turkey lat: 41.005 lon: 39.72694 hasResults: False