hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06264336 id: UIC AHS Pilot 2024 briefTitle: Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis overallStatus: RECRUITING date: 2024-03-01 date: 2024-12-31 date: 2024-12-31 date: 2024-02-16 date: 2024-02-28 name: University of Illinois at Chicago class: OTHER briefSummary: Nearly 1 million individuals in the United States have multiple sclerosis, which causes fatigue and problems with walking. Fatigue and walking problems are poorly treated, but exercise training, particularly high-intensity walking exercise, may help. This provide insight into whether high-intensity walking exercise can improve fatigue and walking problems in people with multiple sclerosis, which could improve quality of life and reduce economic burden. conditions: Multiple Sclerosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: treadmill training measure: Symptomatic fatigue measure: Walking speed measure: Corticomotor excitability measure: Fatigue impact measure: Walking endurance measure: Aerobic capacity measure: Visual processing speed measure: Verbal learning and memory measure: Spatial walking symmetry measure: Temporal walking symmetry measure: Community ambulation measure: Interhemispheric inhibition sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Illinois Chicago status: RECRUITING city: Chicago state: Illinois zip: 60612 country: United States name: Brice T Cleland, PhD role: CONTACT phone: 312-996-9056 email: bcleland@uic.edu lat: 41.85003 lon: -87.65005 hasResults: False
nctId: NCT06264323 id: UI-5487 briefTitle: Incidence of Acute Injuries in Boxing overallStatus: COMPLETED date: 2017-09-01 date: 2018-05-30 date: 2018-11-30 date: 2024-02-16 date: 2024-02-16 name: University of Iceland class: OTHER briefSummary: A prospective cohort study with 9 months follow up was carried out in 2017-2018. Boxers of both sexes 18 years and older from all 7 boxing clubs in Iceland were invited to participate in the study. Participants filled out a questionnaire on previous injuries during boxing training and competition and were evaluated on the Sport Concussion Assessment Tool 3rd edition (SCAT3). Exposure at training and competition was measured and any injuries sustained during the study period were recorded via text messages and phone calls every 2 weeks. conditions: Injuries studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 74 type: ACTUAL measure: Questionnaire measure: Sport Concussion Assessment Tool 3rd Edition (SCAT3) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Iceland city: Reykjavík zip: 102 country: Iceland lat: 64.13548 lon: -21.89541 hasResults: False
nctId: NCT06264297 id: 01-22-270-111 briefTitle: High-Voltage Pulsed Radiofrequency of the Lumbar Dorsal Root Ganglion for the Treatment of Chronic Lumbar Radicular and Neuropathic Pain; A Prospective, Doble-blinded and Randomized Controlled Trial acronym: Radiofrequency overallStatus: RECRUITING date: 2023-02-20 date: 2027-01 date: 2027-12 date: 2024-02-16 date: 2024-02-16 name: Consorci Sanitari de Terrassa class: OTHER briefSummary: The management of chronic lumbar radicular and neuropathic pain is complex and the treatment success rates are low. Pulsed radiofrequency (PRF) has been described in these cases. In order to determine whether high-voltage PRF show better results than PRF a prospective, doble-blinded and randomized study is conducted in patients with chronic lumbar radicular and neuropathic pain. conditions: Pulsed Radiofrequency conditions: Lumbar Radiculopathy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 98 type: ESTIMATED name: Radiofrequency measure: OSWESTRY LOW BACK DISABILITY QUESTIONNAIRE measure: DN4 - QUESTIONNAIRE measure: Visual Numeric Scale measure: Categorical scale measure: patient global impression of improvement (pgi-i) score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Consorci Sanitari de Terrassa status: RECRUITING city: Terrassa state: Barcelona zip: 08227 country: Spain name: Maria Martinez Garcia role: CONTACT phone: +34650528215 email: mariamartinezgarcia@gmail.com role: CONTACT email: mariamartinezgarcia@gmail.com name: maria Martinez Garcia role: PRINCIPAL_INVESTIGATOR lat: 41.56667 lon: 2.01667 hasResults: False
nctId: NCT06264284 id: 2023PI163 briefTitle: Emergency (Red Code) Cesarean Section : Maternal and Fetal Prognosis Depending on Anesthetic Modalities in a Level 3 Maternity Ward overallStatus: COMPLETED date: 2018-07-19 date: 2023-07-19 date: 2023-07-19 date: 2024-02-16 date: 2024-02-16 name: Central Hospital, Nancy, France class: OTHER briefSummary: We try to evaluate whether the type of anesthesia used influences the occurrence of perioperative maternal complications as well as neonatal outcome on emergency (Red Code) Cesarean Section.
This study occurred in a Level 3 Maternity Ward. conditions: Anesthesia Complication studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 150 type: ACTUAL name: epidural anesthesia name: general anesthesia measure: To evaluate whether the type of anesthesia used influences the occurrence of perioperative maternal complications as well as neonatal outcome sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Stanowski city: Nancy zip: 54000 country: France lat: 48.68439 lon: 6.18496 hasResults: False
nctId: NCT06264271 id: GIP-22-NL-06-203 briefTitle: The Effect of Nutrition Education on Glycemic Control in Patients With Type 1 Diabetes overallStatus: COMPLETED date: 2022-02-01 date: 2023-12-31 date: 2024-02-01 date: 2024-02-16 date: 2024-02-20 name: Charles University, Czech Republic class: OTHER name: General University Hospital, Prague briefSummary: The study aims to elucidate whether patients with T1D initiating sensor monitoring experience greater improvement in glycemic control (HbA1c) when provided with structured nutrition education compared to those initiating sensor monitoring without such education. conditions: Diabetes Mellitus, Type 1 studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 329 type: ACTUAL name: structured nutrition intervention measure: difference in HbA1c measure: differences in time in range measure: differences in time below range measure: differences in time above range measure: differences in coefficient of variation sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Charles University city: Prague zip: 12808 country: Czechia lat: 50.08804 lon: 14.42076 hasResults: False
nctId: NCT06264258 id: STUDY2023_00000285 briefTitle: Game-based Pediatric Diabetes Education acronym: DVx-T1D overallStatus: RECRUITING date: 2024-03-01 date: 2024-12-31 date: 2025-06-30 date: 2024-02-16 date: 2024-02-20 name: Carnegie Mellon University class: OTHER name: University of Pittsburgh briefSummary: The goal of this study is to evaluate the impact of a mobile app video game called Digital Vaccine for Type 1 Diabetes (DVx-T1D)™, proposed as a low-risk, non-invasive, digital therapeutic candidate for behavior change in children 6 to 12 years of age with Type 1 Diabetes (T1D).
The investigators hypothesize that adoption of DVx-T1D™ by T1D patients will positively influence healthy dietary and physical activity behaviors by providing nutrition and lifestyle education through a playful, Artificial Intelligence (AI)-based, cartoon-style medium of mobile gaming, and result in improvements in their T1D control. The investigators propose to conduct a longitudinal randomized controlled trial (RCT) over a 3-month period with a study population of 80 T1D participants (40 each in two arms of the trial) of 6-12 years old. The investigators will quantify the impact of the mobile game app plus standard care vs. standard care (with no exposure to the app) on T1D control (assessed by glycosylated hemoglobin or HbA1c measured during clinic visits and continuous glucose monitoring (CGM) parameters measured at home), physical activity levels and food choices of children (measured using food logs and surveys). Game telemetry, food logs, clinical, anthropometric, demographic, and survey data will be collected to obtain adequately powered, theory-driven evidence of the value of game-based approaches delivered via mobile apps. conditions: Diabetes Mellitus, Type 1 conditions: Behavior, Health studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The investigators propose to conduct a longitudinal randomized controlled trial (RCT) over a 3-month period with a study population of 80 participants (40 in each arm) of 6-12 years old youth with type 1 diabetes (T1D).The investigators will quantify the impact of the mobile game app vs. standard care on T1D control (assessed by glycosylated hemoglobin or HbA1c measured during clinic visits and continuous glucose monitoring (CGM) parameters), physical activity levels and food choices of children (measured using food logs and surveys).
The study will also assess changes in children's knowledge about the measured outcomes and investigate the feasibility and acceptability of game adoption and the barriers and challenges faced by patients, families and clinicians. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 80 type: ESTIMATED name: DVx-T1D™ app measure: Change in HbA1c values and and insulin dose adjusted HbA1c before and after the intervention measure: Change in glucose average and variability measure: Changes in the quality of food consumption measure: Change in game play patterns over time sex: ALL minimumAge: 6 Years maximumAge: 12 Years stdAges: CHILD facility: UPMC Children's Hospital of Pittsburgh status: RECRUITING city: Pittsburgh state: Pennsylvania zip: 15224 country: United States name: Neha Sudhir role: CONTACT email: sudhirn2@upmc.edu name: Ingrid Libman, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 40.44062 lon: -79.99589 hasResults: False
nctId: NCT06264245 id: 2022-126 id: 2023-A00985-40 type: OTHER domain: ID RCB briefTitle: Users of Remote Conferencing and Compression of Sound Dynamics : Auditory Effects acronym: COMPRESSED overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-01-15 date: 2025-01-15 date: 2024-02-16 date: 2024-03-06 name: Institut Pasteur class: INDUSTRY name: Institut de l'Audition briefSummary: The COMPRESSED project is a descriptive, bi-centric and non-invasive study carried out by the CERIAH - IDA - Institut Pasteur and the Haute École Léonard de Vinci in Brussels on volunteer participants identified in two groups :
The main objective of the COMPRESSED study is to evaluate the auditory effects of exposure to manipulated sounds (compression, filtering, equalisation, accentuation, etc.) from sound distribution platforms on the auditory system of participants who are regularly exposed to these sounds as a result of their professional activity. conditions: Auditory Perception studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED name: Audiological profile name: Hearing self-assessments name: Objective and subjective audiological tests name: Self-assessment of exposure sound quality measure: Hearing assessments of participants exposed to manipulated sounds after and before exposure measure: Audiometric thresholds in pure tone from 125 to 8000 Hz in the subject's exposed ear before and approximately one hour after exposure, measure: Difference between the threshold of the protective reflex of the auditory pathways (middle ear muscles) measured by impedancemetry in the exposed ear when a contralateral noise is presented for a few seconds. measure: Levels of otoemissions in acoustic distortion products in the exposed ear in response to pure tone sound stimuli measure: Tinnitus or auditory distortion (hyperacusis) reported by participants before and after exposure. measure: Effectiveness of the protective auditory reflexes (or acoustic reflexes), obtained by impedancemetry and derived from the reading of the otoemissions for each participant. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Haute Ecole Léonard De Vinci city: Bruxelles country: Belgium name: Patrick Vereheyden, MD role: CONTACT phone: + 32 2 793 41 43 email: Patrick.Verheyden@vinci.be lat: 50.85045 lon: 4.34878 facility: CEntre de Recherche et d'Innovation en Audiologie Humaine city: Paris zip: 75015 country: France name: Paul Avan, MD role: CONTACT lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06264219 id: H-24002284 briefTitle: Restoration of the Gut Microbiome After Cesarean Section acronym: RestoreGut overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-11-30 date: 2026-11-30 date: 2024-02-16 date: 2024-02-16 name: Professor Klaus Bønnelykke class: OTHER briefSummary: This study aims to develop a therapy for restoring the gut microbiome in infants born via CS. We will conduct a randomized, placebo-controlled feasibility trial to assess the ability of microbiome restoration by FMT and FVT in infants born by cesarean section. conditions: Microbial Colonization studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Microbiome restoration - FMT name: Microbiome restoration - FVT name: Placebo name: Vaginal birth, untreated control measure: Microbial development trajectory measure: Microbial development trajectory sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Copsac, DBAC city: Gentofte state: Copenhagen zip: 2820 country: Denmark lat: 55.74903 lon: 12.54601 facility: Rigshospitalet city: Copenhagen zip: 2100 country: Denmark name: Hanne Hegaard, Professor role: CONTACT phone: +45 27583632 email: Hanne.Kristine.Hegaard@regionh.dk lat: 55.67594 lon: 12.56553 hasResults: False
nctId: NCT06264206 id: CALLA_IVF_KIR briefTitle: Effect of Immunomodulatory Treatment on IVF (in Vitro Fertilization) Outcomes in Patients With KIR AA Genotype overallStatus: COMPLETED date: 2022-01-01 date: 2022-12-31 date: 2023-12-31 date: 2024-02-16 date: 2024-02-16 name: Calla IVF Center class: OTHER briefSummary: The aim of the study is to investigate the immune cause of recurrent implantation failure (RIF) and the role of immunomodulatory treatment in IVF (in vitro fertilization) patients that have a KIR AA genotype. We compared pregnancy rates in Group KIR AA without immunomodulatory treatment, and pregnancy rates in Group KIR AA with immunomodulatory treatment. conditions: Immunomodulatory Drugs conditions: Killer-cell Immunoglobulin-like Receptors (KIRs) conditions: KIR Alleles (KIR AA) studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 65 type: ACTUAL name: Killer-cell immunoglobulin-like receptors (KIRs) testing measure: the incidence of immune cause of recurrent implantation failure measure: the efficiency of immnomodulatory treatment on pregnancy rate in patients with KIR AA measure: comparation between the pregnancy rates in KIR AA group and KIR Bx group sex: FEMALE minimumAge: 18 Years maximumAge: 49 Years stdAges: ADULT facility: Calla Ivf Center city: Oradea state: Bihior zip: 410103 country: Romania lat: 47.0458 lon: 21.91833 hasResults: False
nctId: NCT06264193 id: Rowers briefTitle: The Impact of Hypoxia on the Biochemical and Morphological Parameters of Blood in Rowers. acronym: IHOBMPBR overallStatus: COMPLETED date: 2014-11-30 date: 2014-12-21 date: 2014-12-21 date: 2024-02-16 date: 2024-02-16 name: Poznan University of Physical Education class: OTHER briefSummary: The response to hypoxia is very individual and epending on many aspects, such as the type of training, duration, intensity, or hypoxic stimulus, hypoxia affects the athlete in various ways. The results of this study have shown that 18 days of the LH-TL method does not significantly increase the level of EPO and VEGF in rowers. However, reticulocytes, immature red blood cells, have shown significant differences after 18-d LH-TL between groups. Further research should be carried out to investigate an optimal hypoxic dose and time, which will raise EPO, VEGF, and morphology variables. conditions: Hypoxia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: The hypoxic group included rowers participating in sports training and the LH-TL method, hypoxic rooms (FiO2=14.5%, corresponds to an altitude of 3000 meters). And the control group participating only in sports training and living in normoxic rooms, at the same sports camp. primaryPurpose: DIAGNOSTIC masking: NONE count: 13 type: ACTUAL name: hypoxia measure: Erythropoietin (EPO) mlU/ml measure: vascular endothelial growth factor (VEGF) mlU/ml measure: creatine kinase (CK) ng/ml measure: Hs C-Reactive Protein (hsCRP) mg/L measure: hemoglobin (Hb)g/dL measure: hematocrit (Htc)% measure: red blood cells (RBC)mln/mm3 measure: white blood cells (WBC)10 3/µL measure: reticulocytes (Ret)‰ measure: SpO2 - oxygen saturation (%) measure: bpm - beats per minute(%) sex: MALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06264180 id: RP1-104 briefTitle: VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs (IGNYTE-3) overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2029-01-01 date: 2034-08-31 date: 2024-02-16 date: 2024-02-16 name: Replimune Inc. class: INDUSTRY briefSummary: This is a randomized, controlled, multicenter, open-label Phase 3 clinical study comparing VO in combination with nivolumab versus Physician's Choice treatment for patients with unresectable Stage IIIb-IV cutaneous melanoma whose disease progressed on an anti PD-1 and an anti-CTLA-4 containing regimen (administered either as a combination regimen or in sequence) or who are not candidates for treatment with an anti-CTLA-4 therapy. conditions: Advanced Melanoma studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 400 type: ESTIMATED name: Vusolimogene Oderparepvec name: Nivolumab name: Nivolumab + Relatlimab name: Pembrolizumab name: Single-agent chemotherapy measure: Overall Survival (OS) measure: Progression Free Survival (PFS) measure: Objective Response Rate (ORR) sex: ALL minimumAge: 12 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06264167 id: NODE briefTitle: NODE (groiN ultrasOunD cancEr) acronym: NODE overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-03-31 date: 2028-03-31 date: 2024-02-16 date: 2024-02-16 name: Queensland Centre for Gynaecological Cancer class: OTHER_GOV name: Royal Brisbane and Women's Hospital briefSummary: This study is an open label, prospective, experimental, randomised clinical trial. The primary aim of this study is to determine whether it is feasible to randomise vulvar cancer patients into one of two treatment arms:1) surgical groin node dissection (as delivered though either a sentinel node biopsy or inguinofemoral lymph node dissection (IFL), or 2) serial high-resolution bilateral groin ultrasound surveillance and clinical examination every 2 months. conditions: Vulvar Cancer Stage Ib conditions: Vulvar Cancer Stage II conditions: Lymph Node Metastasis conditions: Groin Node conditions: Ultrasound Therapy; Complications studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Feasibility trial, open label, three-group, randomised clinical trial
Participants with suspicious/indeterminate baseline groin ultrasound (third group) will receive an upfront full groin LND or SNB, consistent with the current standard treatment, according to local clinical practice management guidelines. primaryPurpose: OTHER masking: NONE count: 30 type: ESTIMATED name: High-resolution bilateral groin ultrasound surveillance measure: Feasibility of randomisation: The percentage of patients willing to be randomised to either surgical groin node dissection or serial high-resolution bilateral groin ultrasound surveillance in conjunction with clinical examination every 2 months. measure: Utility of tumour mutations to determine positive lymph node metastasis. measure: Utility of circulating tumour DNA to determine positive lymph node metastasis. measure: Utility of plasma to determine positive lymph node metastasis. measure: Utility of serum to determine positive lymph node metastasis. sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: St Andrew's War Memorial Hospital city: Brisbane state: Queensland zip: 4000 country: Australia name: Sara Baniahmadi role: CONTACT phone: 07 3346 5073 email: s.baniahmadi@uq.edu.au name: Andreas Obermair, Prof role: PRINCIPAL_INVESTIGATOR lat: -27.46794 lon: 153.02809 facility: Royal Brisbane and Women's Hospital city: Brisbane state: Queensland zip: 4029 country: Australia name: Sara Baniahmadi role: CONTACT phone: 07 3346 5073 email: s.baniahmadi@uq.edu.au name: Avalon Knott role: CONTACT phone: 07 3346 5073 email: a.knott@uq.edu.au name: Andrea Garrett, Dr role: PRINCIPAL_INVESTIGATOR lat: -27.46794 lon: 153.02809 hasResults: False
nctId: NCT06264154 id: 854051 id: R01CA287474-01 type: NIH link: https://reporter.nih.gov/quickSearch/R01CA287474-01 briefTitle: The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-06 date: 2027-12 date: 2024-02-16 date: 2024-02-16 name: University of Pennsylvania class: OTHER name: National Cancer Institute (NCI) briefSummary: This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, tobacco-flavored, or menthol-flavored e-cigarettes and be instructed to switch (versus smoking cigarettes) over a 6-week period. Flavor-associated subjective reward and the reinforcing value of flavored e-cigarettes relative to combustible cigarettes will be assessed as mechanisms. conditions: Smoking conditions: Tobacco Use conditions: Cigarette Smoking conditions: E-Cig Use studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 210 type: ESTIMATED name: E-cigarettes measure: Cigarette Consumption measure: Cigarette Smoking Behavior sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False