Additionally, the Portuguese population has a higher prevalence of genome alterations that confer a lower capacity to produce vitamin D from sunlight exposure. These genetic characteristics are present in about 19% of the population, representing a prevalence four times higher than the European average (19% versus 4.75%), leading to a higher predisposition to vitamin D deficiency. conditions: Vitamin D Deficiency conditions: Pregnancy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: Exposure measure: Differences in the rate of Prematurity with different maternal Vitamin D levels measure: Differences in Birth Weight with different maternal Vitamin D levels measure: Differences in Apgar Scores with different maternal Vitamin D levels measure: Differences in the number of admissions to the Neonatal Intensive Care Unit with different maternal Vitamin D levels measure: Differences in the Neonatal Morbidity rate with different maternal Vitamin D levels measure: Differences in the Neonatal Mortality rate with different maternal Vitamin D levels measure: Differences in the number of Neonatal Infections with different maternal Vitamin D levels measure: Differences in the Number of Congenital Malformation diagnoses with different maternal vitamin D levels measure: Differences in the presence of vitamin D-related polymorphisms with different maternal levels of vitamin D measure: Differences in maternal vitamin D levels between the three groups/cohorts related to prematurity measure: Differences in maternal vitamin D levels between the three groups/cohorts related to birth weight measure: Differences in maternal vitamin D levels between the three groups/cohorts related to Apgar scores measure: Differences in maternal vitamin D levels between the three groups/cohorts related to admission to the Neonatal Intensive Care Unit measure: Differences in maternal vitamin D levels between the three groups/cohorts related to neonatal morbidity measure: Differences in maternal vitamin D levels between the three groups/cohorts related to neonatal mortality measure: Differences in maternal vitamin D levels between the three groups/cohorts related to neonatal infections. measure: Differences in maternal vitamin D levels between the three groups/cohorts related to the diagnosis of congenital malformations measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with prematurity measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with birth weight measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with Apgar scores measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with admission to the Neonatal Intensive Care Unit. measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with neonatal morbidity measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with neonatal mortality measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with neonatal infections measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with the diagnosis of congenital malformations sex: FEMALE minimumAge: 16 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Unidade Local de Saúde do Baixo Alentejo status: RECRUITING city: Beja zip: 7801-849 country: Portugal name: Inês Gornilho, MD role: CONTACT email: ines.gornilho@ulsba.min-saude.pt lat: 38.01506 lon: -7.86323 facility: Unidade Local de Saúde do Norte Alentejano status: RECRUITING city: Portalegre zip: 7301-853 country: Portugal name: Vera Escoto, MD role: CONTACT email: veraescoto.ca@ulsaale.min-saude.pt lat: 39.29379 lon: -7.43122 facility: Unidade Local de Saúde do Alentejo Central - Hospital Espirito Santo de Évora status: RECRUITING city: Évora zip: 7000-811 country: Portugal name: Maria OP Barbosa, MSc; PhD Student role: CONTACT phone: 00351966056178 email: mobarbosa@hevora.min-saude.pt name: Fernando Fernandes, MD role: CONTACT phone: 00351965753123 email: ffernandes@hevora.min-saude.pt lat: 38.56667 lon: -7.9 hasResults: False