hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06368076 id: H-23065096 briefTitle: High-intensity Interval Training in Patients With Spinal Muscular Atrophy overallStatus: RECRUITING date: 2024-01-09 date: 2024-08 date: 2025-01 date: 2024-04-16 date: 2024-04-16 name: Rigshospitalet, Denmark class: OTHER briefSummary: Patients with spinal muscular atrophy who are wheelchair users often experience lower back - and gluteal pain, reduced sleep quality, constipation and reduced quality of life - symptoms that regular exercise could potentially alleviate. However, only very little research has been done on exercise for patients who are wheelchair users. The aim of this study is to explore the impact of cycle exercise on patients with spinal muscular atrophy. conditions: Spinal Muscular Atrophy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Exercise measure: Questionnaire on fatigue measure: Questionnaire on pain. measure: Questionnaire on constipation measure: Questionnaire on quality of life measure: Questionnaire on sleep quality measure: Blood sample measure: Blood sample measure: Blood sample measure: Blood sample measure: Blood sample measure: Blood sample measure: Blood sample measure: Blood sample measure: Blood sample measure: Blood sample measure: MRI scan liver size measure: MR-elastography measure: MRI scan liver steatosis measure: Ultrasound scan measure: MRI scan measure: MRI scan measure: Exercise test measure: Motorscore sex: ALL minimumAge: 15 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Rigshospitalet status: RECRUITING city: Copenhagen zip: 2100 country: Denmark name: Sophia Frølich, stud.med role: CONTACT phone: + 45 3545 3561 email: sophia.vera.froelich.01@regionh.dk name: Noémie Receveur, stud.med role: CONTACT phone: +4535453561 email: noemie.anne-marie.receveur.03@regionh.dk lat: 55.67594 lon: 12.56553 hasResults: False
nctId: NCT06368063 id: HE-202301 briefTitle: The Study of Huaier Granule in Postoperative Adjuvant Therapy of Resectable Pancreatic Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-03 date: 2028-03 date: 2024-04-16 date: 2024-04-25 name: Health Science Center of Xi'an Jiaotong University class: OTHER name: LinkDoc Technology (Beijing) Co. Ltd. name: Huazhong University of Science and Technology briefSummary: The study is a multicenter, prospective clinical study aimed at evaluating the efficacy and safety of Huaier Granule in postoperative adjuvant treatment of resectable pancreatic cancer conditions: Pancreatic Cancer Resectable studyType: INTERVENTIONAL phases: PHASE4 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 642 type: ESTIMATED name: Huaier granule name: chemotherapy drugs measure: Disease-free survival measure: Overall survival measure: Progression-free survival measure: The incidence and severity of adverse events (AE) and severe adverse events (SAE) measure: The incidence and severity of ADR, severe adverse reactions (SADR), suspicious and unexpected severe adverse reactions (SUSAR) sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06368050 id: IRB00067187.2 briefTitle: Implementation of an Evidence-Based Intervention to Improve Head Impact Safety in Youth Football overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2024-11 date: 2024-11 date: 2024-04-16 date: 2024-04-16 name: Wake Forest University Health Sciences class: OTHER name: Childress Institute briefSummary: The objective of this study is to evaluate the feasibility of implementing an evidence-based intervention program, COmmunities Aligned to reduce Concussion and Head impact exposure (COACH) on a larger scale. Coaches of 12U (12 years old and under), and 13U (13 years old and under) teams within six youth football organizations will pilot test the intervention. Aim 1 will conduct focus groups with coaches, parents, and organizational leaders to assess organizational needs, capacity, and readiness to adopt the intervention program. Aim 2 will evaluate the effectiveness of the intervention program at reducing HIE and injuries and evaluate implementation success. Aim 2 results (intervention outcomes) are reported herein. conditions: Head Injury conditions: Sport Injury studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 30 type: ESTIMATED name: practice structure intervention measure: Number of practice head impacts measure: Number of practice head acceleration events measure: Practice head impact rate measure: Practice head acceleration even rate measure: Median linear acceleration measure: Median rotational acceleration measure: Median rotational velocity measure: 95th percentile linear acceleration measure: 95th percentile rotational acceleration measure: 95th percentile rotational velocity measure: Feasibility of Intervention Measure (FIM) Values measure: Acceptability of Intervention Measure (AIM) Values measure: Number of practices the intervention was implemented as prescribed measure: Average minutes per practice of live time sex: ALL minimumAge: 11 Years maximumAge: 14 Years stdAges: CHILD facility: Wake Forest University Health Sciences city: Winston-Salem state: North Carolina zip: 27157 country: United States name: Jill Urban, PhD, MPH role: CONTACT phone: 336-716-0947 email: jurban@wakehealth.edu name: Konstantia Strates role: CONTACT phone: 336-713-1263 email: kcstrate@wakehealth.edu name: Jill Urban, PhD, MPH role: PRINCIPAL_INVESTIGATOR lat: 36.09986 lon: -80.24422 hasResults: False
nctId: NCT06368037 id: DragonFire-02 briefTitle: Feasibility Study of the DragonFire for Hypertrophic Obstructive Cardiomyopathy overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-06 date: 2026-06 date: 2024-04-16 date: 2024-04-16 name: Hangzhou Valgen Medtech Co., Ltd class: INDUSTRY briefSummary: This study is a prospective, single-center, single-group design exploratory clinical research. No control group is set, and only subjects meeting the indications of the study device are treated. After patients sign informed consent, they are screened, and those meeting the inclusion criteria are enrolled. The treatment involves using myocardial radiofrequency ablation system and catheter-based myocardial radiofrequency ablation needle and its guidance system for treating obstructive hypertrophic cardiomyopathy. All subjects are followed up before discharge, and at 30 days, 3 months, 6 months, and 12 months postoperatively. conditions: Obstructive Hypertrophic Cardiomyopathy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: DragonFire Transcatheter Myocardial Radiofrequency Ablation System measure: The rate of freedom from major adverse events at 30 days postoperatively measure: The success rate of treatment at 6 months postoperatively sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Northern Theater Command General Hospital of the Chinese People's Liberation Army city: Shenyang country: China lat: 41.79222 lon: 123.43278 hasResults: False
nctId: NCT06368024 id: CL-12-600 briefTitle: Establishment of Delphi-MD Safety Performance and Reliability overallStatus: COMPLETED date: 2023-11-28 date: 2023-11-28 date: 2023-11-28 date: 2024-04-16 date: 2024-04-26 name: QuantalX Neuroscience class: INDUSTRY briefSummary: A retrospective analysis of collected datasets. In this study we aim to establish Delphi-MD's safety and performance reliability for assessment and monitoring of Transcranial Magnetic Stimulation (TMS) Evoked Potentials (TEPs) as neurophysiological measurements. conditions: Neurologic Disorder conditions: Healthy studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: RETROSPECTIVE count: 263 type: ACTUAL name: This is a retrospective analysis study of data collected with a diagnostic medical device measure: Cortical Excitability measure: Specific Peak Amplitudes measure: GMFP sex: ALL minimumAge: 50 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: QuantalX Neuroscience Ltd. city: Kfar Saba state: Center zip: 4453001 country: Israel lat: 32.175 lon: 34.90694 hasResults: False
nctId: NCT06368011 id: MustafaKU-CINCINOGLU-001 briefTitle: The Impact of Acceptance and Commitment Therapy on Stigmatization overallStatus: ENROLLING_BY_INVITATION date: 2023-04-15 date: 2023-07-31 date: 2024-06-30 date: 2024-04-16 date: 2024-04-16 name: Mustafa Kemal University class: OTHER briefSummary: The goal of study is to determine the effect of acceptance and commitment therapy-based psychoeducation on the level of stigmatization applied to relatives of schizophrenia patients.
Intervention: Before the psychoeducation process started, personal information form and scales were applied to the relatives of the patients in the experimental and control groups. An ACT-based psychoeducation program consisting of 8 sessions was applied to the experimental group. each session lasted approximately 90 minutes. The control group did not receive any intervention. After the psychoeducation, the scales were reapplied to the experimental and control groups. In addition, the experimental group was asked to fill out the psychoeducation evaluation form. The scales were reapplied to the experimental group after the 1-month follow-up study and evaluated. conditions: Stigmatization studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 36 type: ESTIMATED name: acceptance and commitment therapy measure: Stigma Scale for Relatives of Patients with Schizophrenia measure: Stigma Scale for Relatives of Patients with Schizophrenia measure: Stigma Scale for Relatives of Patients with Schizophrenia measure: Stigmatization Scale measure: Stigmatization Scale measure: Stigmatization Scale sex: ALL minimumAge: 18 Months stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Hatay Mustafa Kemal Üniversitesi city: Hatay country: Turkey lat: 38.40227 lon: 27.10486 hasResults: False
nctId: NCT06367998 id: PC24MISV0017 briefTitle: The Effect of Pregabalin on Shoulder Pain of Patients With Central Sensitization Who Undergo Arthroscopic Rotator Cuff Repair overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2026-05-01 date: 2024-04-16 date: 2024-04-16 name: The Catholic University of Korea class: OTHER name: Viatris Korea briefSummary: This study aims to investigate the effects of Pregabalin intake on shoulder pain management in patients with central sensitization undergoing arthroscopic rotator cuff repair. Although Pregabalin is known to be effective in controlling pain after shoulder arthroscopy, research on its efficacy in pain management for patients with central sensitization is scarce. Utilizing a list that identifies central sensitization, this study will explore whether Pregabalin can reduce postoperative pain in these patients and potentially improve joint mobility, emotional, and physical functioning. A prospective randomized study is planned, with inclusion criteria set for patients aged between 19 and 70 who have undergone arthroscopic rotator cuff repair.
The study will compare clinical outcomes up to one year postoperatively between two groups of 38 patients each. The case group will receive standard postoperative medications (NSAIDs) plus Pregabalin oral intake from the day before surgery to six weeks postoperatively, while the control group will receive only the standard postoperative medications without Pregabalin. conditions: Rotator Cuff Tears conditions: Central Sensitisation conditions: Neuropathic Pain studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 76 type: ESTIMATED name: Pregabalin measure: VAS pain score measure: Constant shoulder score measure: American shouler and elbow surgeons (ASES) score sex: ALL minimumAge: 20 Years maximumAge: 69 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06367972 id: 2024-0070 id: NCI-2024-03278 type: OTHER domain: NCI-CTRP Clinical Registry briefTitle: A Randomized Phase II Basket Trial EXTENDing Efficacy of Systemic Therapy With Local Consolidative Therapy for OligoProgressive Metastatic Disease (EXTEND-OP) overallStatus: NOT_YET_RECRUITING date: 2024-10-31 date: 2028-10-10 date: 2030-10-10 date: 2024-04-16 date: 2024-04-16 name: M.D. Anderson Cancer Center class: OTHER briefSummary: To find out if local consolidation therapy (such as radiation therapy with or without other local therapies such as surgery, ablation \[the removal or destruction of a body part or tissue or its function\], or embolization \[a procedure that uses particles, such as tiny gelatin sponges or beads, to block a blood vessel\]) to all progressive sites of disease can help to control the disease compared with next-line systemic therapy. conditions: OligoProgressive Metastatic Disease studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 200 type: ESTIMATED name: Local Consolidation Therapy name: Next-line Systemic Therapy measure: Safety and adverse events (AEs) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: MD Anderson Cancer Center city: Houston state: Texas zip: 77030 country: United States name: Ethan Ludmir, MD role: CONTACT phone: 832-729-0998 email: ebludmir@mdanderson.org name: Ethan Ludmir, MD role: PRINCIPAL_INVESTIGATOR lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06367959 id: 2021-0324 id: NCI-2024-02939 type: OTHER domain: NCI-CTRP Clinical Trials Registry briefTitle: Health Benefits of Writing Therapy Among Asian American Cancer Survivors overallStatus: RECRUITING date: 2023-07-27 date: 2026-08-31 date: 2026-08-31 date: 2024-04-16 date: 2024-04-17 name: M.D. Anderson Cancer Center class: OTHER briefSummary: To learn more about participant experience as a Asian American immigrant breast cancer survivor and how writing about participant experiences may affect participant's health. conditions: Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 192 type: ESTIMATED name: Esays name: Questionnaires measure: Primary Outcome Measure: Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: MD Anderson Cancer Center status: RECRUITING city: Houston state: Texas zip: 77030 country: United States name: Qian Lu, MD, PHD role: CONTACT phone: 713-745-8324 email: qlu@mdanderson.org name: Qian Lu, MD, PHD role: PRINCIPAL_INVESTIGATOR lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06367946 id: XH-24-0093 briefTitle: Mechanism Study of Ventilator-Induced Lung Injury in Elderly People. overallStatus: RECRUITING date: 2023-06-01 date: 2024-07-01 date: 2027-06-30 date: 2024-04-16 date: 2024-04-16 name: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine class: OTHER briefSummary: 1. We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age.
2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial/epithelial damage, age and duration of mechanical ventilation. conditions: Ventilator-Induced Lung Injury studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: mechanical ventilation measure: KLK8 concentration of lung tissue measure: Endothelial/epithelial damage index concentration in peripheral blood sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai Xinhua hospital status: RECRUITING city: Shanghai zip: 200000 country: China name: Lai Jiang, PhD role: CONTACT phone: 13817719616__ email: jianglaimz@sina.com lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06367933 id: MISNM briefTitle: Mini-invasive Spine Surgery for Neuromuscolar Scoliosis acronym: MISNM overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2026-05 date: 2024-04-16 date: 2024-04-25 name: Istituto Ortopedico Rizzoli class: OTHER briefSummary: Neuromuscular scoliosis (SNM) are deformities related to the impairment of normal function of the central nervous system (CNS) and/or peripheral nervous system (PNS) resulting in alterations to the of the functional unit represented by the integrated motor sequence (SIM). At the level of the spine, dysfunction of the SIM results in altered dynamic support of the spine. This results in a control of the trunk that is not harmonious due to the lack of effective mechanisms of muscle compensation. In particular, a greater degree of pelvic tilt with respect to the ground plane, with an increase in the degree of the so-called pelvic obliquity (OP), a fundamental parameter in walking and maintaining the seated posture. Spinal deformity causes severe alterations of the rib cage resulting in respiratory failure that often requires ventilatory supports and is associated with frequent airway infections, including pneumonias, often fatal. SNMs also express other comorbidities: cardiac (heart failure), neurological (epilepsy), nutritional that necessitate careful management multidisciplinary and especially anesthesiological evaluation for the peri-operative management. The surgical treatment of SNM constitutes a topic that is still debated due to both the bio-mechanical peculiarities of SNM and the clinical features, particularly comorbidities, that characterize this patient population. Compared with idiopathic scoliosis surgery, in SNM there is a higher rate of complications. To date, most of the complications are respiratory in nature (23%), followed by complications mechanical of the implanted surgical instrumentation (13%), and surgical site infections (11%). Furthermore, there is evidence that SNM surgery correlates with increased blood loss intraoperative. To date, it is recognized in the literature that the safest and most effective surgical treatment for SNMs is arthrodesis posterior instrumented with pedicle screws extended to the pelvis. In the years, mini-invasive surgical techniques have become increasingly prominent. invasive with the goal of reducing operative time, blood loss and complications themselves. conditions: Neuromuscular Scoliosis conditions: Spine Deformity conditions: Surgery conditions: Vertebral Fusion studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: mini-invasive spine surgery measure: Visual Analogue Scale measure: Visual Analogue Scale measure: Spine Correction measure: Spine Correction sex: ALL minimumAge: 9 Years maximumAge: 25 Years stdAges: CHILD stdAges: ADULT facility: Istituto Ortopedico Rizzoli city: Bologna zip: 40136 country: Italy lat: 44.49381 lon: 11.33875 hasResults: False
nctId: NCT06367920 id: 2022-02-005 briefTitle: Multicenter Study on Rehabilitation Medical Data for Pediatric Big Brain Development overallStatus: RECRUITING date: 2023-03-23 date: 2024-12-31 date: 2024-12-31 date: 2024-04-16 date: 2024-04-16 name: Bundang CHA Hospital class: OTHER briefSummary: Retrospective study for development of imaging-genetics (brain imaging/genome big data) models and algorithms that are clinically explainable and have high predictive performance in brain research on pediatric developmental disorders conditions: Pediatric ALL conditions: Healthy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 2000 type: ESTIMATED name: Magnetic Resonance Imaging, Behavioral assessments measure: Brain magnetic resonance imaging measure: Medical records sex: ALL maximumAge: 20 Years stdAges: CHILD stdAges: ADULT facility: CHA Bundang Medical Center, CHA University status: RECRUITING city: Seongnam-si state: Gyeonggi-do zip: 463-712 country: Korea, Republic of name: Minyoung Kim, M.D., Ph.D. role: CONTACT phone: 82-31-780-1872 email: kmin@cha.ac.kr lat: 37.43861 lon: 127.13778 hasResults: False
nctId: NCT06367907 id: SM 68/6-1 briefTitle: Biological Effects of Schema Therapy acronym: BE-ST overallStatus: RECRUITING date: 2021-09-09 date: 2024-12 date: 2025-06 date: 2024-04-16 date: 2024-04-16 name: Jena University Hospital class: OTHER briefSummary: Background: The major aim of this study is to compare the effects of emotion focused (experiential) and cognitive interventions of schema therapy (ST) on emotion regulation deficits in patients with borderline personality disorder (BPD) according to DSM-V (alternative model) criteria. In a randomized, single-blinded parallel-group design clinical effects as well as effects on neurotransmitter metabolism and connectivity will be compared.
Method: While the 9-weeks treatment protocol of particular interest includes emotion focused interventions (ST-EF, n=60) such as chair dialogs, imagery rescripting or role play, the active control condition (ST-AC, n=60) is restricted to cognitive interventions, e.g. psychoeducation or pro/contra discussions. MEGA-PRESS 1H-MR spectroscopy and resting-state functional MR imaging (rs-fMRI) will be used before/after treatment protocols (T0-T1) and 6 months after the end of therapy (T2) to assess the effects on glutamate (Glx) and GABA metabolism in key regions of the target networks (executive control network, ECN: dorsolateral prefrontal cortex, DLPFC; salience network, SN: anteromedial cingulate cortex, aMCC; default mode network, DMN: pregenual cingulate cortex, pgACC) and to investigate the corresponding altered connectivity in these networks. The biological aberrations at T0 as compared to healthy controls (n=60) and treatment effects (at T1 and T2, n≥40 in each condition) on these aberrations will be linked to clinical effects measured by an extensive test battery with particular interest on emotion regulation, and specified by the Reliable Change Index (RCI). For longitudinal data mixed model analysis will be performed.
The main questions are (1) whether the emotion regulation deficit and the pattern of BPD-specific symptomatology are associated with a specific pattern of Glx and GABA concentrations in the DLPFC, aMCC and pgACC and corresponding deviations of functional connectivity within the ECN, SN and DMN. Hypothesis: Depending on primary and secondary outcome measures at T0, altered RSFC in the DMN, SN and ECN and corresponding altered Glx or GABA concentrations are assumed. (2) whether both treatment conditions have different clinical effects on the ability to regulate emotions and whether the respective clinical effects are associated with the changes in neurobiological aberrations. Hypothesis: It is hypothesized that the ST-EF condition will improve emotion regulation skills more effectively than the control condition. Only in the ST-EF condition are higher response and remission rates expected in the primary and secondary outcome measures, as well as effects on the ECN, SN and DMN with corresponding changes in RSFC and Glx or GABA concentrations. conditions: Personality Disorders studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: randomized, parallel-group, single-blinded primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Parallel-group: Both conditions (emotion focussed, ST-EF and active control, ST-AC) are highly standardized and active in terms of their expected clinical effect, which was a precondition for a positive ethics approval.