hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06354673 id: 278/1-April-2024 briefTitle: Stellate Ganglion Block Combined With Dexmedetomidine or Subanesthetic Ketamine Infusion for Treatment of Neurostorm. overallStatus: ENROLLING_BY_INVITATION date: 2024-04-04 date: 2024-09-04 date: 2024-10-04 date: 2024-04-09 date: 2024-04-10 name: Zagazig University class: OTHER_GOV briefSummary: Neurostorming is a sudden and exaggerated stress response as a result of damage to the brain. With appropriate treatment and time, there is hope for individuals to overcome storming, regain consciousness, and work towards successfully recovering from brain injury. Most treatments for neurostorming involve the use of medications only such as dexmedetomidine, opioids, gabapentin and propofol to address secondary complications like high blood pressure and fever. These medications focus on slowing the body's stress response or relaxing the body. Stellate ganglion block (SGB) is a promising therapy for paroxysmal sympathetic hyperactivity (PSH), overcoming the limitations of systemic medications and may serve to recalibrate aberrant autonomic states. Ketamine is a potent dissociative agent which has sedative, analgesic and anesthetic properties beside its sympathomimetic effect. Its combination with stellate ganglion block is to oppose its sympathomimetic effect. Dexmedetomidine has analgesic and sedative effect which inhibits the sympathetic nerve activity through its action on the α2 receptor in the spinal cord. Hypothesis: Null hypothesis: There is no difference between the effects of stellate ganglion block combined with dexmedetomidine or subanesthetic ketamine infusion for treatment of neurostorm after traumatic brain injury in critically ill patients.Alternative hypothesis: There is a difference between the effects of stellate ganglion block combined with dexmedetomidine or subanesthetic ketamine infusion for treatment of neurostorm after traumatic brain injury in critically ill patients.which has sedative, analgesic and anesthetic properties beside its sympathomimetic effect. Aim of the work is achievement of effective treatment for the neurostorm after traumatic brain injury in critically ill patients with better outcomes and decrease intensive care unit (ICU) stay. conditions: Paroxysmal Sympathetic Hyperactivity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 205 type: ESTIMATED name: Stellate ganglion block name: Dexmedetomidine name: Ketamine measure: To compare the time of remission of neurostorm symptoms measure: To assess effect of stellate ganglion block combined with either dexmedetomidine or subanesthetic ketamine infusion on changes in glascow coma scale score. measure: ▪ To measure the duration of intensive care unit (ICU) stay. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Zagazig university city: Zagazig country: Egypt lat: 30.58768 lon: 31.502 hasResults: False
nctId: NCT06354647 id: HM20028419 briefTitle: Zirconia-based Primary Anterior Crowns With Retention Grooves Versus Without Retention Grooves overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-05-01 date: 2027-06-01 date: 2024-04-09 date: 2024-04-09 name: Virginia Commonwealth University class: OTHER briefSummary: The purpose of this research study is to test the effectiveness of two different crowns/caps on teeth for restoration of primary anterior teeth. The two different materials of crowns are esthetic crowns with retentive grooves and without retentive crowns. These crowns are placed on the teeth to restore function, esthetics and prevent further caries and infection. conditions: Dental Caries conditions: Tooth Decay studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 75 type: ESTIMATED name: Zirconia-based primary anterior crowns with retention grooves name: Zirconia-based primary anterior crowns without retention grooves measure: Success of prefabricated Zirconia-based primary anterior crowns with retention grooves compared to Zirconia-based primary anterior crowns without retention grooves through clinical outcomes measure: Success of prefabricated Zirconia-based primary anterior crowns with retention grooves compared to Zirconia-based primary anterior crowns without retention grooves through radiographic outcomes measure: Parental satisfaction measure: Child satisfaction measure: Oral health impact during early childhood sex: ALL minimumAge: 2 Years maximumAge: 6 Years stdAges: CHILD facility: Virginia Commonwealth University city: Richmond state: Virginia zip: 23298 country: United States name: Jayakumar Jayaraman, BDS, MDS, FDSRCS, MS, PhD role: CONTACT phone: (804) 828-9095 email: jayaramanj@vcu.edu name: Alpna Khatri role: CONTACT phone: (571) 302-6719 email: khatria4@vcu.edu lat: 37.55376 lon: -77.46026 hasResults: False
nctId: NCT06354634 id: HM20028439 briefTitle: Resin Polymer (NuSmile BioFlx) Compared to Stainless Steel Crowns (3M ESPE) for Restoration of Primary Molar Teeth overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-07 date: 2027-07 date: 2024-04-09 date: 2024-04-09 name: Virginia Commonwealth University class: OTHER briefSummary: The purpose of this research study is to test the effectiveness of two different crowns/caps on teeth for restoration of primary molar teeth. The two different materials of crowns are resin polymer and stainless steel crowns. These crowns are placed on the teeth to restore function and prevent further caries and infection. conditions: Dental Caries conditions: Tooth Decay studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Each participant will receive both interventions. primaryPurpose: TREATMENT masking: NONE count: 80 type: ESTIMATED name: Resin polymer (NuSmile Bioflx) crown name: Stainless steel crown measure: The success of Bioflx crown in primary molars in comparisons with stainless steel molars through clinical assessments measure: The success of Bioflx crown in primary molars in comparisons with stainless steel molars through radiographic assessments measure: Parental satisfaction measure: Child satisfaction sex: ALL minimumAge: 3 Years maximumAge: 7 Years stdAges: CHILD facility: Virginia Commonwealth University city: Richmond state: Virginia zip: 23298 country: United States name: Jayakumar Jayaraman role: CONTACT phone: 804-828-2362 email: jayaramanj@vcu.edu lat: 37.55376 lon: -77.46026 hasResults: False
nctId: NCT06354621 id: D/185/FIMS briefTitle: Impact of Vitamin D Supplementation on Fetomaternal Outcomes in LTBI Pregnant Females acronym: RCT overallStatus: COMPLETED date: 2023-09-01 date: 2024-02-28 date: 2024-03-20 date: 2024-04-09 date: 2024-04-09 name: University of the Punjab class: OTHER briefSummary: The goal of this randomized controlled trial is to see the effect of vitamin D supplementation on fetomaternal outcomes in pregnant females with Latent Tuberculosis infection
If Vitamin D supplementation has any impact on maternal outcomes. If Vitamin D supplementation has any impact on fetal outcomes. conditions: Maternal and Child Health studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 99 type: ACTUAL name: Vitamin-D supplementation measure: Pre-Eclampsia (Maternal Outcome) measure: Gestational Diabetes Mellitus (Maternal Outcome) measure: C/Section delivery (Maternal Outcomes) measure: Low Birth Weight (Foetal Outcome) measure: Pre-Term delivery (Foetal Outcome) measure: Apgar Score (Foetal Outcome) measure: Improvement in maternal vitamin-D levels sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: University of the Punjab city: Lahore state: Punjab zip: 54600 country: Pakistan lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06354608 id: duygudemirr briefTitle: The Effect of Audio Book and Local Vibration on Pain and Fear in Intramuscular Injection in Children overallStatus: RECRUITING date: 2023-10-25 date: 2024-04-01 date: 2024-04-30 date: 2024-04-09 date: 2024-04-09 name: University of Yalova class: OTHER briefSummary: The study is conducted based on a randomized controlled experimental design to determine the effect of an audio book and local vibration on intramuscular injection in pediatric emergency unit patients aged 4-6 years on pain and fear. conditions: Procedural Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This study is an experimental, parallel-group (intervention-control), randomized controlled design primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 120 type: ESTIMATED name: Audio Book Group name: Local Vibration Group measure: Comparison of the pain score values of the groups Pain assesed by Wong-Baker FACES measure: Comparison of the fear score values of the groups measure: Comparison of the fear score values of the groups sex: ALL minimumAge: 4 Years maximumAge: 6 Years stdAges: CHILD facility: University of Yalova status: RECRUITING city: Yalova country: Turkey name: Duygu Demir, PhD role: CONTACT phone: +905053662358 email: duygu.emir@yalova.edu.tr lat: 40.65501 lon: 29.27693 hasResults: False
nctId: NCT06354595 id: XiamenU1 briefTitle: Feasibility Study of Multidimensional Rehabilitation in the Metaverse overallStatus: RECRUITING date: 2024-03-01 date: 2024-04-30 date: 2024-05-01 date: 2024-04-09 date: 2024-04-09 name: Qu Shen class: OTHER name: The First Affiliated Hospital of Xiamen University briefSummary: The investigators evaluated and optimized the Metaverse multi-dimensional rehabilitation platform based on the use of the Metaverse multi-dimensional rehabilitation platform by colorectal cancer survivors and their families, and finally launched the Metaverse multi-dimensional rehabilitation platform. conditions: Colorectal Neoplasms studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DEVICE_FEASIBILITY masking: NONE count: 10 type: ESTIMATED name: Multidimensional Rehabilitation in the Metaverse measure: Post-Study System Usability Questionnaire (PSSUQ) Third Edition measure: System Usability Scale (SUS) measure: Semi-structured interview sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Yuru Hu status: RECRUITING city: Xiamen state: Fujian zip: 361005 country: China name: Yuru HU role: CONTACT phone: 18189530895 email: 15903017593@163.com lat: 24.47979 lon: 118.08187 hasResults: False
nctId: NCT06354582 id: 2024-085-01 briefTitle: Effect of Intravenous Vitamin C on Intrapartum Maternal Fever After Epidural Labor Analgesia acronym: EIVCIMFAELA overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-01 date: 2025-02 date: 2024-04-09 date: 2024-04-09 name: Kunyue Li class: OTHER name: Third Affiliated Hospital of Zhengzhou University briefSummary: This study aims to explore the effect of intravenous vitamin C infusion on intrapartum fever after epidural labor analgesia, to reduce the impact of intrapartum fever on maternal and infant, improve maternal and infant outcomes, and provide a reference for clinical preventive medication. conditions: Obstetric Labor Complications conditions: Fever studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Parturients are randomly assigned to either vitamin C(1,2,3) or control. The vitamin C group received 1 g, 2g, and 3g of vitamin C intravenously respectively and the control group received normal saline, administered after the induction of epidural labor anesthesia. There will be 100 cases in each group. The infusion speed will be set at 5ml/min. primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 400 type: ESTIMATED name: Vitamin C Injection name: Normal saline measure: Intrapartum fever or not measure: The temperature of parturients measure: The duration of intrapartum fever measure: Complete blood count indicators measure: Visual analogue scale(VAS) measure: Amount of total analgesics measure: Side effects on mothers measure: the duration of total labor measure: Incidence of rupture of membranes measure: Delivery characteristics 2 measure: Record the weight of the baby. measure: Record the gender of the baby. measure: Apgar score measure: the incidence of fetal distress measure: Record the infant ward administration. sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT hasResults: False
nctId: NCT06354569 id: 2022.232 briefTitle: Risk Factors and Risk Grading Prediction of Perioperative Respiratory Adverse Events in Children overallStatus: RECRUITING date: 2024-12-31 date: 2024-12-31 date: 2024-12-31 date: 2024-04-09 date: 2024-04-09 name: Sichuan Provincial People's Hospital class: OTHER briefSummary: to explore the risk factors of perioperative respiratory adverse events in children, and to establish a risk prediction model of perioperative respiratory adverse events in children conditions: Perioperative Respiratory Adverse Events studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 600 type: ESTIMATED measure: The occurrence of perioperative respiratory adverse events sex: ALL minimumAge: 1 Month maximumAge: 12 Years stdAges: CHILD facility: Sichuan provincial Peopel'Hospital status: RECRUITING city: Chengdu state: Sichuan country: China name: Yanyu Liu role: CONTACT phone: +8613438348895 email: 43197113@qq.com name: Ting Xu role: CONTACT phone: +8317708130267 lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06354556 id: HRS-1893-102 briefTitle: Effect of Verapamil Tablets on the Pharmacokinetic of HRS-1893 Tablets in Healthy Subjects overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-05-05 date: 2024-05-30 date: 2024-04-09 date: 2024-04-09 name: Shandong Suncadia Medicine Co., Ltd. class: INDUSTRY briefSummary: The purpose of this phase Ⅰ study is to evaluate the effect of oral verapamil tablets on the pharmacokinetics of HRS-1893 in healthy subjects. conditions: Obstructive Hypertrophic Cardiomyopathy studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single center, open, single arm, fixed sequence primaryPurpose: TREATMENT masking: NONE count: 14 type: ESTIMATED name: HRS-1893 tablet name: Verapamil tablet measure: Maximum observed serum concentration (Cmax) for HRS-1893 after Single dose measure: Area under the plasma concentration versus time curve from time zero to last measurable timepoint (AUC0-t) for HRS-1893 after single dose measure: Area under the plasma concentration versus time curve from time zero extrapolated to infinity (AUC0-inf) for HRS-1893 after single dose measure: Time to maximum observed serum concentration (Tmax) for HRS-1893 after single dose measure: Elimination half-life (T1/2) for HRS-1893 after single dose measure: Apparent oral clearance (CL/F) for HRS-1893 after single dose measure: Apparent volume of distribution (Vz/F) for HRS-1893 after single dose measure: Accumulated amount of excretion (Ae) for HRS-1893 after single dose measure: Urinary excretion fraction（fe）for HRS-1893 after single dose measure: Renal clearance（CLr）for HRS-1893 after single dose measure: Number of subjects with adverse events and the severity of adverse events sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT hasResults: False
nctId: NCT06354543 id: CA01-TK-ARTHRO briefTitle: Arthroplasty Cements Outcomes - A Post-market Follow-up overallStatus: RECRUITING date: 2020-12-16 date: 2035-12 date: 2045-12 date: 2024-04-09 date: 2024-04-09 name: Teknimed class: INDUSTRY briefSummary: A Post-Market Clinical Follow-Up (PMCF) Study to collect clinical data on safety and performance of all Teknimed Arthroplasty range of products: CEMFIX® and GENTAFIX® bone cements families and CEMSTOP® cement restrictor, and all their private labels.
The study is a retrospective and prospective global, single arm, non-controlled, multicentric, ambispective observational study. Patients will be followed as per local standard medical care of the site. conditions: Arthroplasty studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 1050 type: ESTIMATED name: Cemented joint arthroplasty measure: Survival rate measure: Superficial and/or deep postoperative infection rate. measure: Pain Level measure: Patients' satisfaction measure: Restoration of function measure: Evaluation of function and radiological outcomes measure: Complications rate measure: Antalgic consumption measure: Restoration of function measure: Restoration of function measure: Adverse events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clinique du Vivarais status: RECRUITING city: Aubenas state: Auvergne-rhône-alpes zip: 07200 country: France name: Michel MILAIRE, MD role: CONTACT email: michel.milaire@yahoo.com name: Michel MILAIRE, MD role: PRINCIPAL_INVESTIGATOR lat: 44.62006 lon: 4.38994 facility: Clinique du Val d'Ouest status: RECRUITING city: Ecully state: Auvergne-rhône-alpes zip: 69130 country: France name: Benoît GIRAUD, MD role: CONTACT email: b.giraud@chirortho-valdouest.fr name: Benoît GIRAUD, MD role: PRINCIPAL_INVESTIGATOR lat: 45.77726 lon: 4.77481 facility: Cabinet de consultation status: RECRUITING city: Evreux state: Eure zip: 27000 country: France name: Edouard DECRETTE, MD role: CONTACT email: decrette.edouard@gmail.com name: Edouard DECRETTE, MD role: PRINCIPAL_INVESTIGATOR lat: 49.02414 lon: 1.15082 facility: Clinique du Dr Henri Guillard status: RECRUITING city: Coutances state: Normandie zip: 50200 country: France name: Olivier COSSART, MD role: CONTACT email: o.cossart@hotmail.fr name: Olivier COSSART, MD role: PRINCIPAL_INVESTIGATOR lat: 49.05 lon: -1.43333 facility: Clinique de l'Atlantique status: RECRUITING city: Puilboreau state: Nouvelle-aquitaine zip: 17138 country: France name: Cédric BOUQUET, MD role: CONTACT email: docteurbouquet@gmail.com name: Cédric BOUQUET, MD role: PRINCIPAL_INVESTIGATOR lat: 46.1862 lon: -1.11797 facility: Hôpital Européen Marseille status: RECRUITING city: Marseille state: Provence-alpes-cote D'azur zip: 13003 country: France name: Maxime MUNIER, MD role: CONTACT email: dr.maxime.munier@gmail.com name: Maxime MUNIER, MD role: PRINCIPAL_INVESTIGATOR lat: 43.29551 lon: 5.38958 facility: Ospedale Santissima Annunziata status: RECRUITING city: Cento state: Emilie-Romagne zip: 44042 country: Italy name: Luca CASTAGNINI, MD role: CONTACT email: luca.castagnini@ausl.fe.it name: Luca CASTAGNINI, MD role: PRINCIPAL_INVESTIGATOR lat: 44.73099 lon: 11.28716 facility: Instituto Ortopedico Rizzoli status: RECRUITING city: Bologna state: Émilie-Romagne zip: 40136 country: Italy name: Stefano ZAFFAGNINI, MD role: CONTACT email: stefano.zaffagnini@unibo.it name: Stefano ZAFFAGNINI, MD role: PRINCIPAL_INVESTIGATOR lat: 44.49381 lon: 11.33875 hasResults: False
nctId: NCT06354530 id: 2023 (315) briefTitle: A Study of Neoadjuvant Therapy for the Treatment of Patients With Locally Advanced Esophageal Squamous Cell Carcinoma overallStatus: RECRUITING date: 2024-03-08 date: 2025-12-31 date: 2026-12-31 date: 2024-04-09 date: 2024-04-09 name: Army Medical Center of PLA class: OTHER_GOV briefSummary: The goal of this interventional study is to compare the safety and efficacy of neoadjuvant immunotherapy plus chemotherapy and anlotinib versus immunotherapy combined with concurrent chemoradiotherapy in the treatment of locally advanced esophageal squamous cell carcinoma. The main question it aims to answer is: To evaluate the safety and efficacy of neoadjuvant immunotherapy plus chemotherapy and anlotinib versus immunotherapy combined with concurrent chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma and to explore the optimal preoperative neoadjuvant treatment regimen for esophageal squamous cell carcinoma. conditions: Neoadjuvant Therapy conditions: Esophageal Squamous Cell Carcinoma studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 266 type: ESTIMATED name: anlotinib name: Thoracic radiotherapy measure: Pathological complete response (pCR), Major pathological response (MPR) measure: Major pathological response (MPR) measure: Objective response rate (ORR) measure: 3-year disease free survival measure: R0 excision rate measure: 3-year overall survival sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Army Medical Center of PLA status: RECRUITING city: Chongqing state: None Selected country: China name: Mengxia Li role: CONTACT phone: +86-18580408265 email: mengxia.li@outlook.com name: Xiao Yang role: CONTACT phone: +86-19923257675 email: yangxiao625@outlook.com lat: 29.56278 lon: 106.55278 hasResults: False
nctId: NCT06354517 id: YIU-M-CI-003 briefTitle: The Impact of the SENSE Program on NICU overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-05-30 date: 2025-05-30 date: 2024-04-09 date: 2024-04-09 name: Yuksek Ihtisas University class: OTHER briefSummary: The SENSE program will be applied to babies receiving treatment in the neonatal intensive care unit and the effect of the application on the baby and parents will be examined. conditions: Pre-Term conditions: Individualized Developmental Care conditions: Sensory Experiences studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 60 type: ESTIMATED name: SENSE group measure: Hammersmıth Neonatal Neurologıcal Examınatıon measure: Parental Stress Scale: Neonatal Intensive Care Unit measure: State-trait Anxiety Inventory measure: Edinburgh Postnatal Depression Scale sex: ALL minimumAge: 24 Weeks maximumAge: 42 Weeks stdAges: CHILD facility: Yuksek Ihtisas University city: Ankara country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06354504 id: 20.02.2019/177 briefTitle: Bactericidal Permeability Protein Inhibitor and Interleukin-1beta Levels After Non-surgical Periodontal Treatment overallStatus: COMPLETED date: 2019-11-19 date: 2020-09-20 date: 2020-09-20 date: 2024-04-09 date: 2024-04-09 name: Akdeniz University class: OTHER briefSummary: The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival crevicular fluid (GCF) levels of bactericidal/permeability-increasing protein (BPI) and interleukin-1beta (IL-1ß). conditions: Periodontitis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ACTUAL name: Non-surgical periodontal treatment measure: Gingival crevicular fluid Bactericidal/permeability-increasing proteins levels measure: Gingival crevicular fluid interleukin-1Beta levels sex: ALL minimumAge: 22 Years maximumAge: 64 Years stdAges: ADULT facility: Akdeniz Üniversity city: Antalya zip: 07070 country: Turkey lat: 36.90812 lon: 30.69556 facility: Akdeniz Üniversitesi Diş Hekimliği Fakültesi city: Antalya country: Turkey lat: 36.90812 lon: 30.69556 hasResults: False