hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06373016 id: 2015P000652 id: 2023005 type: OTHER_GRANT domain: Baszucki Foundation briefTitle: Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder overallStatus: RECRUITING date: 2024-01-26 date: 2027-02-01 date: 2027-02-01 date: 2024-04-18 date: 2024-04-18 name: Stony Brook University class: OTHER name: Massachusetts General Hospital name: Mclean Hospital briefSummary: The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar. The main question it aims to answer is how glucose and ketones each affect the brain's response to risk and reward. Participants will be asked to provide blood (to assess baseline measures of how the body uses energy), and then to receive two MRI scan sessions, on separate days. During each MRI scan session, participants will play three games, from which they can win money, before and after drinking glucose (on one day) or ketones (on the other day). Investigators will compare individuals with and without bipolar to test whether the two groups differ in how their brains use energy, and to test how the brain's use of energy affects behavior. conditions: Bipolar Disorder conditions: Bipolar Disorder Type 1 studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 100 type: ESTIMATED name: Glucose name: Ketones measure: Stabilization of brain networks (general brain functioning) measure: Relative stabilization or destabilization of brain networks in response to metabolic bolus measure: Prefrontal-limbic circuit regulation measure: Cortico-striatal circuit regulation measure: Concentration of neurometabolites measured by Magnetic Resonance Spectroscopy (MRS) sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: McLean Hospital status: RECRUITING city: Belmont state: Massachusetts zip: 02478 country: United States name: Dost Ongur, MD PhD role: CONTACT phone: 617-855-3922 email: dongur@mgb.org name: Virginie-Anne Chouinard, MD role: CONTACT phone: 617-855-3034 email: vchouinard@mgb.org name: Dost Ongur, MD PhD role: PRINCIPAL_INVESTIGATOR lat: 42.39593 lon: -71.17867 facility: Martinos Center for Biomedical Research, Building 149, 13th Street status: RECRUITING city: Charlestown state: Massachusetts zip: 02129 country: United States name: Lilianne Mujica-Parodi, PhD role: CONTACT phone: 631-428-8461 email: lstrey@mgh.harvard.edu name: Eva-Maria Ratai, PhD role: CONTACT phone: 781-521-4436 email: eratai@mgh.harvard.edu name: Eva-Maria Ratai, PhD role: PRINCIPAL_INVESTIGATOR lat: 42.37787 lon: -71.062 facility: Laufer Center for Physical and Quantitative Biology , Stony Brook University status: ACTIVE_NOT_RECRUITING city: Stony Brook state: New York zip: 11794 country: United States lat: 40.92565 lon: -73.14094 hasResults: False
nctId: NCT06373003 id: SNAPSITA briefTitle: Negative Antiphospholipid Syndrome: a Multicentric Study acronym: SNAPSITA overallStatus: RECRUITING date: 2024-03-31 date: 2026-03-31 date: 2026-03-31 date: 2024-04-18 date: 2024-04-18 name: Italian Society for Rheumatology class: OTHER briefSummary: Multicentre no-profit, national, (cross-sectional diagnostic) retrospective study, promoted by the Italian Society for Rheumatology.
(i)Patients fulfilling the classification criteria for antiphospholipid syndrome (seropositive APS, SP-APS) or patients with seronegative APS (SN-APS) or patients with clinical criteria (thrombotic or obstetric) for APS, negative for aPL, but without clinical features highly suggestive of APS; (ii) Age \<65 years; (iii) less than 5 years from the first event to the beginning of the study. conditions: Antiphospholipid Syndrome conditions: Seronegative Antiphospholipid Syndrome studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 105 type: ESTIMATED name: Diagnostic accuracy measure: Primary endpoint measure: Secondary endpoint_1 measure: Secondary endpoint_2 measure: Secondary endpoint_3 measure: Exploratory Endpoint sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UOC di Reumatologia - AOU Policlinico Umberto I, "Sapienza" Università di Roma status: RECRUITING city: Roma state: Rome zip: 00185 country: Italy name: Simona Truglia, MD role: CONTACT phone: 06 49974631 email: simona.truglia@uniroma1.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06372990 id: 0015338 briefTitle: Rapid T-cell Analysis Test in Patients With Chronic HBV and HBV/HDV Disease acronym: BDTc overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-09-30 date: 2026-09-30 date: 2024-04-18 date: 2024-04-18 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico class: OTHER name: Duke-NUS Medical School (Singapore) briefSummary: Prospective, non-pharmacological, single-center, non-profit observational study.
The primary objective of the study is to define the prevalence of specific T cell responses in patients with chronic HBV and HBV-HDV infection, through the application of a specific rapid T cell assay. conditions: HBV conditions: HBV/HDV studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 300 type: ESTIMATED measure: Define the prevalence of specific T cell responses in patients with chronic HBV and HBV-HDV infection, through the application of a specific rapid T cell assay measure: Evaluate differences in terms of T cell response in patients with chronic HBV infection vs. HBV-HDV measure: Correlate the T cell response phenotype with the clinical profile (chronic infection vs. chronic hepatitis), disease severity (cirrhosis vs. non-cirrhosis) and response to specific HBV and HBV-HDV therapies measure: Improve the rapid T cell analysis protocol by simplifying the process, reducing analysis time and/or reducing the amount of material (blood) needed sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Division of Gastroenterology and Hepatology, Milan, Italy. city: Milano state: MI zip: 20122 country: Italy name: Pietro Lampertico, MD role: CONTACT phone: 0255035432 email: pietro.lampertico@unimi.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06372977 id: kappa index in ms briefTitle: Kappa Index Versus Csf Oligoclonal Bands in Diagnosis of ms and Prediction of Disease Activity overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-12 date: 2026-05 date: 2024-04-18 date: 2024-04-18 name: Assiut University class: OTHER briefSummary: To:
2. Assess the role of kappa free light chain and oligoclonal bands in predicting disease activity (conversion from clinical isolated syndrome to multiple sclerosis) conditions: Multiple Sclerosis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 140 type: ESTIMATED name: kappa index measure: Assess the diagnostic performance of CSF k index in differentiating MS from other inflammatory and non-inflammatory neurological diseases . measure: Assess the diagnostic performance of CSF IgG OCBs in differentiating MS from other inflammatory and non-inflammatory neurological diseases . measure: Assess the role of k FLC in predicting disease activity (conversion from CIS to MS) measure: Assess the role of OCBs in predicting disease activity (conversion from CIS to MS) sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT hasResults: False
nctId: NCT06372951 id: Lung ultrasound in neonate briefTitle: Lung Ultrasound in Neonatal Intensive Care Units overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-03 date: 2026-03 date: 2024-04-18 date: 2024-04-18 name: Assiut University class: OTHER briefSummary: Identification of lung diseases causing neonatal respiratory distress by lung ultrasound as a tool that can replace x-ray . conditions: Neonatal Respiratory Distress studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 132 type: ESTIMATED name: Ultrasound measure: Identifying causes of neonatal respiratory distress sex: ALL minimumAge: 1 Day maximumAge: 28 Days stdAges: CHILD hasResults: False
nctId: NCT06372938 id: AEŞH-BADEK-2024-43 briefTitle: Role of Inflammatory Markers and Doppler Parameters in Late-Onset Fetal Growth Restriction: A Machine Learning Approach overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-31 date: 2024-04-30 date: 2024-04-30 date: 2024-04-18 date: 2024-04-18 name: Ankara Etlik City Hospital class: OTHER_GOV briefSummary: Fetal growth restriction (FGR) is a serious complication in pregnancy that can lead to various adverse outcomes. It's classified into early-onset (before 32 weeks) and late-onset (after 32 weeks), with late-onset associated with long-term risks like hypoxemia and developmental delays. The study focuses on the role of inflammation in FGR, introducing new blood markers for better understanding and diagnosis. It also addresses the challenges of using advanced diagnostic tools in low-resource settings and explores the use of machine learning to predict FGR based on inflammatory markers, highlighting the potential of artificial intelligence in overcoming these challenges. conditions: Fetal Growth Restriction conditions: Inflammatory Response studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 240 type: ACTUAL name: Ultrasound measurement name: Laboratory Tests and Inflammatory Markers measure: Evaluation of data measure: Machine learning modeling sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Etlik City Hospital city: Ankara state: Yenimahalle zip: 06170 country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06372925 id: CKJX839A1CN04 id: CKJX839A1CN04 type: OTHER domain: Novartis briefTitle: Intravascular Imaging Study of the Effect of Inclisiran on Plaque in Patients With Acute Myocardial Infarction acronym: V-ACCELERATE overallStatus: NOT_YET_RECRUITING date: 2024-07-23 date: 2026-06-24 date: 2026-06-24 date: 2024-04-18 date: 2024-04-18 name: Novartis Pharmaceuticals class: INDUSTRY briefSummary: This study is to evaluate the effect of Inclisiran on coronary atherosclerosis using intravascular ultrasound (IVUS) and optical coherence tomography (OCT) in patients with acute myocardial infarction and elevated low-density lipoprotein cholesterol (LDL-C). conditions: Plaque, Atherosclerotic studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: IVUS/OCT will be conducted in local lab and blinded analyzed to Independent Review Committee(IRC). whoMasked: OUTCOMES_ASSESSOR count: 318 type: ESTIMATED name: atorvastatin name: IVUS/OCT name: inclisiran measure: Change in percent atheroma volume (PAV) measure: Change in minimum fibrous cap thickness (FCT) measure: Change in mean minimum FCT of all images measure: Change in normalized total atheroma volume (NTAV) measure: Proportion of participants with progression, regression, or no change in PAV measure: Change in LDL-C measure: Change in TC measure: Change in HDL-C measure: Change in non-HDL-C measure: Change in ApoB measure: Change in ApoA1 measure: Change in Lp(a) measure: Change in TG measure: Proportion of participants with LDL-C target attainment sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06372912 id: Complications-Bariatric-TJ briefTitle: Early Postoperative Complications in Patients Undergoing Bariatric Surgery overallStatus: RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2024-12-31 date: 2024-04-18 date: 2024-04-18 name: Instituto Mexicano del Seguro Social class: OTHER_GOV briefSummary: This study examined immediate postoperative complications in patients undergoing various bariatric surgeries, aiming to evaluate the safety and efficacy of these interventions. Conducted at specialized high-volume bariatric surgery centers in Tijuana, Mexico. Predominantly female patients with severe obesity underwent procedures like sleeve gastrectomy and Roux-en-Y gastric bypass. Immediate complications were rare, occurring in only 0.38% of patients, with bleeding being the most common issue. Surgical reintervention within 48 hours was required in 0.33% of cases. The study's low complication rate suggests that surgeon expertise is crucial in minimizing risks and improving postoperative outcomes in bariatric surgery. conditions: Bariatric Surgery Candidate conditions: Complication,Postoperative studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 3000 type: ESTIMATED name: Sleeve gastrectomy, Roux-en-Y gastric bypass, mini-gastric bypass, SADIS, intragastric balloon insertion, and gastric band placement are bariatric surgeries. measure: Rate of Postoperative Complications measure: Long-term Weight Loss Efficacy sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Elias Ortiz & Company Mexico Weight Loss Specialists. Ernesto Sarmiento 2308, Tijuana 22046, Baja California, Mexico. status: RECRUITING city: Tijuana state: Baja California zip: 22046 country: Mexico name: José a Guzmán Barba, MD, PhD role: CONTACT phone: 3471043237 email: • aldogbarba@hotmail.com lat: 32.5027 lon: -117.00371 hasResults: False
nctId: NCT06372899 id: 855140 id: R01CA290541-01A1 type: NIH link: https://reporter.nih.gov/quickSearch/R01CA290541-01A1 briefTitle: Alternative Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-11 date: 2028-03-31 date: 2024-04-18 date: 2024-04-19 name: University of Pennsylvania class: OTHER name: National Cancer Institute (NCI) briefSummary: This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to ECIGS or ONPS and be instructed to switch (versus smoking cigarettes) over a 6-week period. Relative reductions in biomarkers of exposure will be measured. ECIG- and ONP-associated subjective reward and the reinforcing value of ECIGS and ONPS relative to combustible cigarettes will be assessed as mechanisms. conditions: E-cigarette Use conditions: Cigarette Smoking conditions: Harm Reduction conditions: Tobacco Use studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: NONE count: 200 type: ESTIMATED name: E-cigarettes name: Oral nicotine pouches measure: Cigarette Consumption measure: Cigarette Smoking Across Follow-Up measure: Biomarkers of Exposure: Carbon Monoxide (CO) measure: Biomarkers of Exposure: Mean mid-expiratory forced expiratory flow (FEF25% - 75%) measure: Biomarkers of Exposure: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) measure: Biomarkers of Exposure:1-hydroxypyrene (1-HOP) sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06372886 id: 2402-147-1516 briefTitle: Clinical Outcomes of Preservation Versus Resection of Portal/Superior Mesenteric Vein During Pancreaticoduodenectomy in Pancreatic Cancer Patients Who Respond to Neoadjuvant Treatment overallStatus: COMPLETED date: 2012-01-01 date: 2022-01-01 date: 2024-03-01 date: 2024-04-18 date: 2024-04-18 name: Seoul National University Hospital class: OTHER briefSummary: 1. There is a lack of evidence on the need to perform portal/superior mesenteric vein (PV/SMV) resection routinely in pancreatic ductal adenocarcinoma (PDAC) patients with venous involvement who responded to neoadjuvant treatment (NAT).
4. We propose that if dissection is possible and there is a high likelihood of achieving R0 resection after NAT, routine PVR may be unnecessary in PDAC patients with venous involvement. conditions: Pancreatic Head Cancer Patients Who Underwent Surgery After Neoadjuvant Treatment studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 264 type: ACTUAL name: portal/superior vein resection measure: 5-year overall survival measure: 5-year portal/superior mesenteric vein stenosis free survival sex: ALL maximumAge: 79 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06372873 id: 2023PHB211-001 briefTitle: Deep-learning For Ultrasound Classification of Anterior Talofibular Ligament Injury overallStatus: ACTIVE_NOT_RECRUITING date: 2024-04-01 date: 2024-04-30 date: 2025-05-30 date: 2024-04-18 date: 2024-04-23 name: Peking University People's Hospital class: OTHER briefSummary: Ultrasound (US) is a more cost-effective, accessible, and available imaging technique to assess anterior talofibular ligament (ATFL) injuries compared with magnetic resonance imaging (MRI). However, challenges in using this technique and increasing demand on qualified musculoskeletal (MSK) radiologists delay the diagnosis. Using datasets from multiple clinical centers, the investigators aimed to develop and validate a deep convolutional network (DCNN) model that automates classification of ATFL injuries using US images with the goal of providing interpretable assistance to radiologists and facilitating a more accurate diagnosis of ATFL injuries.
The investigators collected US images of ATFL injuries which had arthroscopic surgery results as reference standard form 13 hospitals across China;Then the investigators divided the images into training dataset, internal validation dataset, and external validation dataset in a ratio of 8:1:1; the investigators chose an optimal DCNN model to test its diagnostic performance of the model, including the diagnostic accuracy, sensitivity, specificity, F1 score. At last, the investigators compared the diagnostic performance of the model with 12 radiologists at different levels of expertise. conditions: Deep Learning conditions: Ultrasound conditions: Anterior Talofibular Ligament studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: RETROSPECTIVE count: 3000 type: ESTIMATED name: re-evaluate by two senior radiologists in our medical center measure: To evaluate whether the US images are in consensus with the ATFL injury classification of the reference standard sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking University People's Hospital city: Beijing state: Beijing zip: 100032 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06372860 id: RKS2018350 id: 3P20GM144269-02S2 type: NIH link: https://reporter.nih.gov/quickSearch/3P20GM144269-02S2 briefTitle: DPP Feasibility Study of Breastfeeding - eMOMS 2.0 overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2025-02 date: 2024-04-18 date: 2024-04-18 name: University of Kansas Medical Center class: OTHER name: Ascension Health name: National Institute of General Medical Sciences (NIGMS) briefSummary: The purpose of this study is to investigate the impact of a comprehensive intervention that combines breastfeeding support with a diabetes prevention-based program (DPP) on postpartum weight retention and lactation duration among women with pre-pregnancy overweight or obesity. This intervention, named eMOMS, is delivered by a certified health coach via a mobile health (mHealth) application. conditions: Overweight or Obesity conditions: Pregnancy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: Diabetes Prevention Program name: Breastfeeding name: Usual Care measure: Maternal weight measure: Maternal body mass index (BMI) measure: Initiation of Lactation measure: Duration of Lactation measure: Type of Infant Feeding measure: Recruitment Rate measure: Retention Rate measure: Research Engagement measure: Mobile Application Usage measure: Health Coach Interaction sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2024-02-07 uploadDate: 2024-04-09T16:15 filename: Prot_SAP_000.pdf size: 1164859 hasResults: False
nctId: NCT06372847 id: Project ID 6214 briefTitle: DISE-HNS Effect Study acronym: DISE-HNS overallStatus: NOT_YET_RECRUITING date: 2024-04-23 date: 2028-03-31 date: 2028-03-31 date: 2024-04-18 date: 2024-04-18 name: University Hospital, Antwerp class: OTHER briefSummary: The purpose of this study is to assess the site, pattern and degree of upper airway collapse before and during hypoglossal nerve stimulation (HNS) treatment using clinical standard drug-induced sleep endoscopy (DISE) and using a novel, non-invasive method predicting site of collapse from raw polysomnography (PSG) data.
Furthermore, outcomes will be compared between responders and non-responders. conditions: Obstructive Sleep Apnea studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Before-and-after study primaryPurpose: BASIC_SCIENCE masking: NONE count: 58 type: ESTIMATED name: Hypoglossal nerve stimulation implant name: Polysomnography name: Drug-induced sleep endoscopy (DISE) measure: Δ%area-of-collapse at the level of the lateral walls measure: Δ%area-of-collapse at the level of the palate, tongue base and epiglottis measure: Δ%area-of-collapse at each possible site of upper airway collapse (palate, lateral walls, tongue base, epiglottis) in responders and non-responders measure: DISE-score during baseline DISE and during one-year follow-up DISE. measure: Non-invasive site and pattern of collapse sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2024-02-29 uploadDate: 2024-04-04T04:58 filename: Prot_SAP_000.pdf size: 425782 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-02-29 uploadDate: 2024-04-04T04:58 filename: ICF_001.pdf size: 336420 hasResults: False