hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06348472 id: 0004-24-SHA briefTitle: The Predictive Role of Immune-inflammatory Biomarkers and Their Interaction With the Oxytocin System in Trauma-related Psychotherapy Responsiveness overallStatus: RECRUITING date: 2024-03-14 date: 2028-03-01 date: 2028-03-01 date: 2024-04-04 date: 2024-04-04 name: Shalvata Mental Health Center class: OTHER briefSummary: Despite a range of treatments for posttraumatic stress disorder (PTSD), only a small proportion of patients reach full symptomatic remission. Recent developments in the field of neuroscience have been providing compelling evidence to suggest that neurobiological determinants might influence not only the emergence of PTSD, but also its resistance to treatment. Immune-inflammation regulatory processes were found to be active during recovery from PTSD, potentially through interactive relationship with the oxytocin secretion system. This innovative longitudinal study aims to examine the role of inflammatory biomarkers and their interactive effect with the oxytocin (OT) system on the development of PTSD and on treatment response among patients with PTSD symptoms undergoing psychotherapy treatment. Patients (N = 100) suffering from trauma-related distress will be recruited from the trauma clinic in Shalvata Mental Health Center. Participants will be followed for 12 weeks of once-a-week psychotherapy sessions. They will be measured for endogenous OT level and cytokines levels in saliva before and after sessions 1, 6, and 12, and will complete psychotherapy outcome self-report questionnaires following each of these sessions. conditions: Posttraumatic Stress Disorder studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 100 type: ESTIMATED measure: Oxytocin Secretion measure: Inflammatory Response: IL-1β measure: Inflammatory Response: IL-6 measure: Inflammatory Response: TNF-α measure: Posttraumatic stress disorder symptoms measure: Depression severity measure: General anxiety symptoms measure: Psychological resilience measure: Working Alliance sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shalvata Mental health Center status: RECRUITING city: Hod HaSharon country: Israel name: Omer Sedoff, MA role: CONTACT email: omerse@clalit.org.il lat: 32.15934 lon: 34.8932 hasResults: False
nctId: NCT06348459 id: 18/010-E briefTitle: Registry of Catheter Intervention in Pulmonary Embolism acronym: RiTEP overallStatus: RECRUITING date: 2018-09-18 date: 2029-12-31 date: 2030-12-31 date: 2024-04-04 date: 2024-04-04 name: Hospital San Carlos, Madrid class: OTHER name: Asociación de Cardiología Intervencionista de la Sociedad Española de Cardiología briefSummary: Multicenter longitudinal observational ambispective (retrospective cases from 2014 and prospective from 2018 onwards) cohort study. The registry recruits a series of consecutive patients admitted for moderate-high risk or high-risk pulmonary embolism (according to 2019 European Society of Cardiology guidelines) treated invasively. This study aims to describe the acute management of the safety and effectiveness of different percutaneous interventions for acute pulmonary embolism. conditions: Pulmonary Embolism conditions: Pulmonary Embolism Acute Massive conditions: Pulmonary Embolism Acute conditions: Pulmonary Embolism and Thrombosis conditions: Pulmonary Thromboembolisms studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 300 type: ESTIMATED measure: All cause-death measure: all cause-death measure: all cause-death measure: all cause-death measure: procedural success measure: in-hospital complications sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Clinico San Carlos status: RECRUITING city: Madrid zip: 28040 country: Spain name: Pablo Salinas, MD, PhD role: CONTACT phone: +34913303000 email: salinas.pablo@gmail.com lat: 40.4165 lon: -3.70256 hasResults: False
nctId: NCT06348446 id: FY20-2963 briefTitle: Tacrolimus Exposure in Kidney Transplantation overallStatus: RECRUITING date: 2022-02-01 date: 2024-07-30 date: 2024-08-30 date: 2024-04-04 date: 2024-04-04 name: Seoul National University Hospital class: OTHER name: Astellas Pharma Inc briefSummary: Using CDW data from 5 tertiary hospitals in Korea, this study identify the optimal range of trough level that can prevent adverse outcome in the early periods after transplantation. conditions: Kidney Transplant Rejection studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 12000 type: ESTIMATED measure: relationship between time varying periodic mean of tacrolimus trough and a composite 1-year allograft outcomes measure: relationship between time varying periodic mean of tacrolimus trough level during 12-72 mo. post-transplant and 6-year composite allograft outcome measure: relationship between post-transplant time varying periodic mean tacrolimus trough level and severe infection measure: relationship between post-transplant time varying periodic mean tacrolimus trough level and cardiovascular event measure: relationship between post-transplant time varying periodic mean tacrolimus trough level and patient mortality sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Asan medical center, Seoul, Korea status: RECRUITING city: Seoul country: Korea, Republic of name: Young Hoon Kim, MD role: CONTACT phone: 82-10-2705-6998 email: kyh-001@hanmail.net lat: 37.566 lon: 126.9784 facility: Samsung medical center, Seoul, Korea status: RECRUITING city: Seoul country: Korea, Republic of name: Jae Berm Park, MD role: CONTACT phone: 82-10-8971-1953 email: jbparkmd@gmail.com lat: 37.566 lon: 126.9784 facility: Seoul St. Mary's hospital, Seoul, Korea status: RECRUITING city: Seoul country: Korea, Republic of name: Sun Cheol Park, MD role: CONTACT phone: 82-10-6310-2847 email: sun60278@catholic.ac.kr lat: 37.566 lon: 126.9784 facility: Severance hospital, Seoul, Korea status: RECRUITING city: Seoul country: Korea, Republic of name: kyuha Hur, MD role: CONTACT phone: 82-10-2043-9947 email: KHHUH@yuhs.ac lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06348420 id: 2023-QILU-LU 03 briefTitle: Anti-reflux Mucosal Valvuloplasty Versus PPIs for GERD Treatment acronym: ARMV overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2027-04-20 date: 2027-08-13 date: 2024-04-04 date: 2024-04-04 name: Qilu Hospital of Shandong University class: OTHER name: Shandong University briefSummary: The study objective is to evaluate the relative merits, safety and effectiveness of Anti-reflux mucosal valvuloplasty (ARMV) in GERD patients currently treated with daily Proton Pump Inhibitors (PPIs). conditions: Gastroesophageal Reflux Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 74 type: ESTIMATED name: anti-reflux mucosal valvuloplasty (ARMV) measure: The total score of the GERD-HRQL questionnaire measure: Number of Participants with PPI usage measure: Appearance of the mucosal flap measure: Presence of reflux esophagitis measure: Safety evaluation indicators measure: Total score of GERD GerdQ questionnaire measure: DeMeester score sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
nctId: NCT06348407 id: 2024-BA-001 briefTitle: A Clinical Study of Omalizumab in the Treatment of Allergic Asthma(ESSENCE) acronym: ESSENCE overallStatus: RECRUITING date: 2023-12-01 date: 2024-11-30 date: 2024-11-30 date: 2024-04-04 date: 2024-04-04 name: The First Affiliated Hospital with Nanjing Medical University class: OTHER briefSummary: Allergic asthma being the most widespread and easily identifiable phenotype, accounting for 60-80% of cases.Previous studies have reported that nearly 90% of patients with severe asthma were cases of allergic asthma, in which Immunoglobulin E (IgE) plays a critical role.Omalizumab was approved as an anti-IgE humanized monoclonal antibody for the treatment of patients with poorly controlled moderate-to-severe asthma, and was the first targeted drug used in the field of asthma treatment.The drug was launched in mainland China in August 2017.whereas,the clinical application experience, effects, and relevant data in the domestic population still lacking.The aim of this study was to observe the efficacy and safety of omalizumab, and to investigate whether baseline clinical characteristics and biomarkers can predicted response and adherence to treatment. conditions: Moderate to Severe Allergic Asthma studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 300 type: ESTIMATED name: IgE monoclonal antibody measure: Change in Asthma Control Test (ACT) measure: Global Evaluation of Treatment Effectiveness (GETE) measure: Forced Expiratory Volume in 1 second（FEV1) measure: FEV1/predicted%. measure: Forced Vital Capacity （FVC） measure: FEV1/FVC. measure: Number of Acute Exacerbations（AE） measure: Oral glucocorticoid dosage measure: Good adherence measure: Poor adherence measure: Adverse events sex: ALL minimumAge: 14 Years maximumAge: 90 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Linfu zhou status: RECRUITING city: Nanjing state: Jiangsu zip: 210000 country: China name: Xuejun Zhang, Master role: CONTACT phone: 86+13704726254 email: zxj1301@163.com lat: 32.06167 lon: 118.77778 hasResults: False
nctId: NCT06348394 id: 023-318 briefTitle: Intracardiac Versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion acronym: ICETEE overallStatus: ACTIVE_NOT_RECRUITING date: 2023-12-14 date: 2025-12-14 date: 2025-12-30 date: 2024-04-04 date: 2024-04-04 name: Baylor Research Institute class: OTHER briefSummary: This single-center, prospective, randomized study will evaluate the safety and feasibility of Intracardiac echocardiography (ICE)-guided Left atrial appendage closure (LAAC) when compared to the traditional Transesophageal echocardiography (TEE) approach. conditions: Left Atrial Appendage Closure studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Prospective, randomized, parallel controlled, open-label, single center study primaryPurpose: OTHER masking: NONE count: 444 type: ESTIMATED name: Intracardiac Echocardiography measure: Procedural success following implantation of the left atrial appendage occlusion (LAAO) device. measure: Periprocedural complications measure: Procedural characteristics measure: Patient satisfaction measure: Periprocedural complications measure: Periprocedural complications measure: Procedural characteristics measure: Procedural characteristics measure: Procedural characteristics sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Baylor Scott and White Heart Hospital city: Plano state: Texas zip: 75093 country: United States lat: 33.01984 lon: -96.69889 hasResults: False
nctId: NCT06348381 id: IS24030 briefTitle: Prediction of Anastomotic Complications and Recurrent Laryngeal Nerve Injury Based on Postoperative Early Endoscopic Evaluation overallStatus: RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-12-31 date: 2024-04-04 date: 2024-04-04 name: Shanghai Chest Hospital class: OTHER briefSummary: Analyze the correlation between the conformity of the anatomy (based on endoscopic examination) and postoperative anastomotic fistula and anastomotic stenosis; establish an anastomotic classification; and construct a predictive model combined with perioperative-related test indicators to provide more accurate risk assessment for clinical practice. Analyze the natural recovery process of postoperative recurrent laryngeal nerve injury in esophageal cancer by tracking vocal cord movement (based on endoscopic examination) and hoarseness symptoms; combined with perioperative related surgical and laboratory indicators, identify the relevant risk factors associated with delayed recovery of recurrent laryngeal nerve injury. conditions: Esophageal Neoplasm conditions: Anastomotic Leak conditions: Recurrent Laryngeal Nerve Injuries conditions: Anastomotic Stenosis conditions: Endoscopic Evaluation studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 250 type: ESTIMATED name: No intervention measure: anastomotic leak measure: anastomotic stenosis measure: laryngeal nerve injury sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai Chest Hospital, Shanghai Jiao Tong University status: RECRUITING city: Shanghai zip: SH 21 country: China name: Zhigang Li, Doctor role: CONTACT phone: 86-18930619260 email: zhigang.li@shchest.org lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06348368 id: Soh-Med-23-01-29 briefTitle: Refractive and Corneal Topographic Characteristics in Upper Egypt Children With High Cylinder overallStatus: COMPLETED date: 2023-01-01 date: 2024-01-30 date: 2024-02-01 date: 2024-04-04 date: 2024-04-09 name: Sohag University class: OTHER briefSummary: Refractive and Corneal Topographic Characteristics in upper Egypt children with high cylinder: A cross sectional study conditions: Corneal Ectasia studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 4000 type: ACTUAL name: Pentacam and autorefractometry measure: Values anterior and posterior corneal elevation values by pentacam. sex: ALL minimumAge: 7 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Elshimaa A.Mateen city: Sohag country: Egypt lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06348355 id: D5084C00016 id: 2023-508334-34-00 type: OTHER domain: EMA-CTIS briefTitle: A Positron-emission Tomography Study to Determine Brain Exposure of [11C]Savolitinib in Healthy Volunteers overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2024-06-28 date: 2024-06-28 date: 2024-04-04 date: 2024-04-04 name: AstraZeneca class: INDUSTRY briefSummary: The purpose of this study is to measure brain exposure of \[11C\]savolitinib in healthy volunteers.
This study will determine brain exposure of \[11C\]savolitinib in up to 8 healthy volunteers under physiological conditions, ie, when the BBB is intact. The study design allows up to 3 site visits. Two PET examinations will be performed for each healthy volunteer. The first PET examination will use IV administration of \[11C\]savolitinib. The second PET examination using \[11C\]savolitinib will occur after a single oral dose of 300 mg of savolitinib. PET image analysis will include kinetic compartment modelling using arterial input function, and will generate a set of brain exposure parameters (eg, maximum %ID, maximum \[11C\]savolitinib concentration in brain, partition coefficients between brain and plasma). conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 8 type: ESTIMATED name: [11C]savolitinib name: Savolitinib measure: Percentage of injected radioactivity entering the brain (%ID) as %IDmax_brain measure: The following endpoint: Cmax_brain SUV measure: The following endpoint: Tmax brain measure: The following endpoint: AUCbrain 0-90 measure: The following endpoint: AUCplasma 0-90 measure: The following endpoint: Kp measure: The following endpoint: Kp,uu measure: The following endpoint: VT measure: The following endpoint: Cmax_brain SUV measure: The following endpoint: Tmax brain measure: The following endpoints: AUCbrain 0-90 measure: The following endpoints: AUCplasma 0-90 measure: The following endpoints: Kp measure: The following endpoints: Kp,uu measure: The following endpoints: VT measure: Number of participants with safety findings, AEs sex: ALL minimumAge: 45 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Research Site city: Solna zip: 171 64 country: Sweden lat: 59.36004 lon: 18.00086 hasResults: False
nctId: NCT06348342 id: TÜTF-GOBAEK 2023/24 briefTitle: Pelvic Floor Muscle Exercises and Core Exercises in Menopausal Women overallStatus: ENROLLING_BY_INVITATION date: 2023-10-15 date: 2024-04-20 date: 2024-06-30 date: 2024-04-04 date: 2024-04-04 name: Trakya University class: OTHER briefSummary: The prospective and four-arm randomized controlled study was conducted on n = 136 (34 = control, 34 = kegel, 34 = core, 34 = kegel+ core group) menopausal women at Trakya University Health Research and Application Center Urology Polyclinic between Oct 2023 and June 2024. In the first interview, the researcher will apply an information form to all four groups, asking about personal information, habits, bladder irritants and fluid intake-related features, obstetric, gynecological and systemic disease-related features, and stress urinary incontinence-related features. This form will only be filled at the beginning. In addition, the \&#34;Pelvic Floor Distress Scale (PFDI)\&#34; and \&#34;Pelvic Floor Impact Questionnaire (PFIQ)\&#34; will be applied and will be repeated by the executive researcher at the 1st, 2nd and 3rd controls. It will be terminated at the 3rd follow-up. Descriptive statistics, Pearson, Spearman\&#39;s correlation, and regression analyzes will be used in the analysis of research data. conditions: Menopause conditions: Stress Urinary Incontinence conditions: Kegel Exercises conditions: Core Strength studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Before starting the research, four groups of mothers will be randomly formed. As a randomization method, mothers who meet the sampling inclusion criteria determined in the research will be identified and listed. Individuals to be taken into two groups will be determined by randomization method from the random numbers table. (http://www.stattrek.com/statistics/randomnumbergenerator.aspx). primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 136 type: ESTIMATED name: Pelvic Floor Muscle Exercise name: Core Exercise measure: Pelvic floor evaluated using the Pelvic Floor Distress Inventory (PFDI - Pelvic Floor Distress Inventionary) measure: Pelvic floor impact evaluated using the Pelvic Floor Impact Questionnaire (PFIQ Pelvic Floor Impact Questionnaire) measure: Urinary incontinence evaluated using the Stress Test measure: Urinary incontinence evaluated using the Uroflowmetry measure: Urinary incontinence evaluated using the Pelvic Floor Muscle Strength Measurement measure: Urinary incontinence evaluated using the Digital Palpation sex: FEMALE minimumAge: 45 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bartın University city: Bartin zip: 78100 country: Turkey lat: 41.63583 lon: 32.3375 hasResults: False
nctId: NCT06348329 id: TÜTF-GOBAEK 2023/41 briefTitle: Pregnant Women Participating in Birth Preparation Training With Their Spouses on the Parenting Role, Attitudes of Their Spouses Towards Participating in the Birth, and Birth Self-Efficacy overallStatus: RECRUITING date: 2023-06-29 date: 2023-10-15 date: 2024-04-15 date: 2024-04-04 date: 2024-04-04 name: Trakya University class: OTHER briefSummary: In this prospective, randomized controlled study, it was aimed to examine the effect of pregnant women participating in birth preparation training together with their partners on the parenting role, spouses' attitudes towards participation in birth, and birth self-efficacy.
Before starting the research, two groups will be randomly formed among pregnant women. As a randomization method, pregnant women who meet the sampling inclusion criteria determined in the research will be identified and listed. Individuals to be taken into two groups will be determined by randomization method from the random numbers table. (http://www.stattrek.com/statistics/randomnumber-generator.aspx). conditions: Birth Order conditions: Parenting conditions: Self Efficacy conditions: Pregnancy Related studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 158 type: ESTIMATED name: Birth Preparation Training measure: Parenting behavior evaluated using the Postpartum Parenting Behavior Scale measure: Parenting self-efficacy in labor evaluated using the Self-Efficacy in Labor Scale measure: Spouse support evaluated using the Spouse Support Scale measure: Father candidates towards participating in the birth evaluated using the Attitude Scale for Father Candidates Towards Participating in the Birth sex: ALL minimumAge: 18 Years maximumAge: 49 Years stdAges: ADULT facility: Trakya University status: RECRUITING city: Edirne zip: 22030 country: Turkey name: Burcu Küçükkaya role: CONTACT phone: 05422931357 email: burcukucukkaya1992@gmail.com lat: 41.67719 lon: 26.55597 hasResults: False
nctId: NCT06348316 id: TÜTF-GOBAEK 2023/45 briefTitle: Early Half Swaddling and Kangaroo Care Practices on Maternal Sleep Quality and Postpartum Depression in Term Babies overallStatus: RECRUITING date: 2023-09-30 date: 2024-04-02 date: 2024-07-30 date: 2024-04-04 date: 2024-04-04 name: Trakya University class: OTHER briefSummary: Aim: In this prospective, randomized controlled study, it was aimed to examine the effects of early half-swaddle and kangaroo care practices in term babies on maternal sleep quality and postpartum depression.
Design: The prospective, randomized controlled study conditions: Mothers conditions: Postpartum Depression studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 136 type: ESTIMATED name: Half swaddle name: Kangaroo care measure: Mother sleep quality evaluated using the Pittsburgh Sleep Quality Index (PSQI) measure: Postpartum depression evaluated using the Edinburgh Postnatal Depression Scale (EPDS) sex: FEMALE minimumAge: 18 Years maximumAge: 49 Years stdAges: ADULT facility: Trakya University status: RECRUITING city: Edirne zip: 22030 country: Turkey name: Burcu Küçükkaya role: CONTACT phone: 05422931357 email: burcukucukkaya1992@gmail.com lat: 41.67719 lon: 26.55597 hasResults: False