hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06338020 id: RHPT/0022/0042 briefTitle: Adaptive Variable-Resistance Training in Pediatric Survivors of Acute Lymphoblastic Leukemia overallStatus: COMPLETED date: 2022-12-29 date: 2024-01-04 date: 2024-01-04 date: 2024-03-29 date: 2024-03-29 name: Cairo University class: OTHER briefSummary: This study was designed to investigate the effect of eight weeks of adaptive variable-resistance training (Adaptive-VRT) on chemotherapy-induced sarcopenia, fatigue, and functional restrictions in a convenience sample of pediatric survivors of acute lymphoblastic leukemia (ALL). Sixty-two pediatric survivors of ALL were randomly allocated to the experimental group (n = 31, received the adaptive variable-resistance training) or the Control group (n = 31, received standard physical therapy care). Both groups were assessed for muscle mass, strength, fatigue, and functional capacity before and after treatment. conditions: Acute Lymphoblastic Leukemia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A prospective, dual-arm, randomized controlled trial primaryPurpose: TREATMENT masking: SINGLE maskingDescription: This was a single-blind protocol. The researcher who collected the data was blind to the allocation of treatment. whoMasked: OUTCOMES_ASSESSOR count: 62 type: ACTUAL name: Adaptive variable-resistance training name: Standard physical therapy measure: Thigh muscle thickness measure: Muscle strength measure: Fatigue measure: Six-minute walk test measure: 4x10 meter Shuttle Run test measure: Timed up and down stairs test sex: ALL minimumAge: 12 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Ragab K. Elnaggar city: Al Kharj state: Riyadh country: Saudi Arabia lat: 24.15541 lon: 47.33457 hasResults: False
nctId: NCT06338007 id: 2012-KAEK-15/2702 briefTitle: Relationship Between Hand Dynamometer Measurements, PFT, and mFI With Postoperative Outcomes overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-09-01 date: 2025-01-01 date: 2024-03-29 date: 2024-04-17 name: Atatürk Chest Diseases and Chest Surgery Training and Research Hospital class: OTHER briefSummary: The study will take place at SBÜ Ankara Atatürk Sanatorium Training and Research Hospital and will include 100 patients over the age of 40 who are scheduled for lung malignancy surgery after 01 April 2024. Informed consent will be obtained from all patients, who will be assigned a number from 1 to 100.
For patients over 40 years of age who are scheduled to undergo lung malignancy resection surgery, demographic data including age, gender, height, weight, body mass index (BMI), diagnosis, comorbidities, and ASA (American Society of Anaesthesiologist) score will be recorded. In addition, hand grip strength measurement, pulmonary function test, and modified frailty index (a scoring system that includes 11 parameters) will be recorded prior to surgery. Intraoperative and postoperative complications will be documented. The duration of the patient's stay in the intensive care unit, chest tube removal, length of hospital stay, and postoperative complications will also be recorded. A follow-up call will be made to the patient by the responsible researcher 90 days after the operation to inquire about any complications that may have developed within that time frame.
The study aims to investigate the relationship between preoperative hand grip strength measurement, pulmonary function test analysis (PFT), and modified frailty index with the duration of intensive care unit stay, chest tube withdrawal time, hospital stay, and postoperative complications in patients undergoing lung resection due to malignancy. conditions: Complication,Postoperative conditions: Lung Cancer studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Hand Dynamometer name: Pulmonary Function Test name: Modified Frailty Index measure: Complication sex: ALL minimumAge: 40 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ankara Atatürk Sanatorium Training and Research Hospital city: Ankara state: Keçiören zip: 06290 country: Turkey name: Gülay ÜLGER, specialist role: CONTACT phone: 05059532122 phoneExt: +9 email: gulayulger@gmail.com name: Onur KÜÇÜK, specialist role: SUB_INVESTIGATOR lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06337994 id: AUH-Neurol-TBI_2024 briefTitle: Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury overallStatus: RECRUITING date: 2024-01-01 date: 2024-06-01 date: 2024-12-30 date: 2024-03-29 date: 2024-03-29 name: Assiut University class: OTHER briefSummary: Posttraumatic consequences are common causes of disability and long-term morbidity. They include cognitive dysfunction, seizures, headache, dizziness, fatigue, sensory deficits, neurodegeneration and psychiatric disorders (e.g. posttraumatic stress disorder, depression, anxiety, etc). Diffuse axonal injury and disruption of normal neuronal function are the most common and important pathologic features of traumatic primary closed head injury. depression, anxiety, etc). Excitotoxicity and apoptosis caused by activation of N-methyl-D-aspartate (NMDA) glutamate receptors, are two main suggested mechanisms of traumatic neuronal cell death and posttraumtic neurologic adverse consequences. Experimental and clinical studies have demonstrated that memantine hydrochloride, NMDA-type glutamate receptor antagonist, could have beneficial effect in treatment of posttraumatic cognitive dysfunction. Memantine may contribute to cognitive improvements in TBI by decreasing the synaptic 'noise' resulting from excessive NMDA receptor activation, inhibition of β-amyloid mediated toxicity and readjustment of the balance between inhibition and excitation on neuronal networks in the central nervous system (CNS). conditions: Treatment of Posttraumatic Cognitive Dysfunction studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: parallel assignment primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Memantine Hydrochloride measure: The severity of traumatic brain injury (TBI) measure: The symptoms of depression measure: The symptoms of anxiety measure: The cognitive function measure: Quality of life measure: The cognitive function sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Assiut University, Faculty of Medicine, Hospital of Neurology, Psychiatry and Neurosurgery status: RECRUITING city: Assiut zip: 71516 country: Egypt name: Sherifa A Hamed, M.D. role: CONTACT phone: +201115324560 email: hamedsherifa@aun.edu.eg name: Sherifa A Hamed, MD role: PRINCIPAL_INVESTIGATOR lat: 27.18096 lon: 31.18368 hasResults: False
nctId: NCT06337981 id: 21DE20901 briefTitle: Efficacy and Safety of AJU-S56 in Dry Eye Syndrome Patients overallStatus: COMPLETED date: 2021-11-22 date: 2022-06-14 date: 2022-11-28 date: 2024-03-29 date: 2024-04-29 name: AJU Pharm Co., Ltd. class: INDUSTRY name: GL Pharm Tech Corporation briefSummary: This study is planned to Evaluate the Efficacy and Safety of test drug (AJU-S56) compared to control drug(vehicle) in Patients with Dry Eye Disease. conditions: Dry Eye Syndromes studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 99 type: ACTUAL name: (AJU-S56 5% and placebo) name: AJU-S56 5% name: Placebo(Vehicle) measure: Total corneal staining score (TCSS) measure: LGCSS measure: TFBUT sex: ALL minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT facility: AJU Pharm Co., Ltd. city: Seoul country: Korea, Republic of lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06337968 id: Circum-Psoas Block LN briefTitle: CPB for Arthroscopic Hip Surgery overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-04-30 date: 2025-05-31 date: 2024-03-29 date: 2024-04-19 name: The Second Hospital of Shandong University class: OTHER briefSummary: Arthroscopic hip surgery is being increasingly performed to treat both intraarticular and extraarticular hip diseases. Despite the minimally invasive approach, patients undergoing arthroscopic hip surgery still suffer severe pain due to the complex nature of hip innervation. Postoperative pain reduces patient satisfaction and delay patient recovery and discharge. The efficacy of regional anesthesia techniques in postoperative pain management have been proved in various surgeries. However, it remains controversial whether or not peripheral nerve blocks can significantly improve postoperative analgesia after hip arthroscopy.
Several studies have shown that the fascia iliac block cannot improve postoperative analgesia for hip arthroscopy because it blocks only some branches of the lumbar plexus but not the sacral plexus. Circum-Psoas Block (CPB) which has been defined in recent years is able to block the lumbar plexus nerves as well as sacral plexus such as the sciatic, superior gluteal, and inferior gluteal nerves. Therefore, the investigators predict that it can provide effective postoperative analgesia for hip arthroscopy. In this study, the researchers aim to investigate the effectiveness of CPB in hip arthroscopy. conditions: Acute Pain conditions: Opioid Use studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 74 type: ESTIMATED name: Circum-psoas Block name: Sham block measure: pain severity at 6 hours postoperatively measure: Postoperative opioid consumption measure: Postoperative nausea and vomiting measure: neurologic evaluation measure: Patient satisfaction sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06337955 id: 20170007596 briefTitle: Non Primary HCMV Infection: Natural History and Immune Response overallStatus: ACTIVE_NOT_RECRUITING date: 2017-06-06 date: 2024-09 date: 2024-12 date: 2024-03-29 date: 2024-04-01 name: Foundation IRCCS San Matteo Hospital class: OTHER name: Università degli Studi di Pavia name: Merck Sharp & Dohme LLC name: Fondazione Regionale per la Ricerca Biomedica (FRRB) - Regione Lombardia briefSummary: The goals of this observational study are: i) investigate the natural history of non-primary (i.e. reactivation and reinfection) HCMV infection in HCMV-seropositive Italian women and the relevant humoral and cell-mediated immune response; ii) reliably distinguish between reactivation and reinfection.
To increase the likelihood of exposure to different HCMV strains, the study population is restricted to mothers of children attending day care centers. conditions: Cytomegalovirus Infections studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 204 type: ACTUAL measure: HCMV non-primary infection (reinfection or reactivation). measure: HCMV-specific humoral and cell-mediated immune response during non-primary infection. measure: Maternal behaviours and occurrence of non-primary infection measure: Potential use of saliva swabs for antibody determination. sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione IRCCS Policlinico San Matteo city: Pavia state: PV zip: 27100 country: Italy lat: 45.19205 lon: 9.15917 hasResults: False
nctId: NCT06337942 id: 23-001621 briefTitle: Deceased Donor Bladder or Combined Kidney-bladder Transplantation: a Phase 0 First-in-human Study overallStatus: RECRUITING date: 2024-04-01 date: 2025-04 date: 2027-04 date: 2024-03-29 date: 2024-03-29 name: University of California, Los Angeles class: OTHER briefSummary: The goal of this clinical trial is to demonstrate the feasibility of bladder transplantation in patients with terminal bladder diseases who would benefit from a new bladder or a combined kidney and bladder transplant. The main questions it aims to answer are:
Participants will undergo a bladder-only or combined kidney and bladder transplantation. They will then be followed for two years to evaluate the efficacy, safety, and functionality of the bladder transplant. conditions: Bladder Disease conditions: Bladder, Neurogenic conditions: Bladder Cancer conditions: Kidney Failure studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 5 type: ESTIMATED name: Bladder Transplantation name: Combined Kidney and Bladder Transplantation measure: Demonstrating the technical success of bladder or combined kidney-bladder transplantation measure: Incidence of adverse events after bladder or combined kidney-bladder transplantation measure: Incidence of immune rejection after bladder or combined kidney-bladder transplantation measure: Evaluate the functionality of the transplanted bladder sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UCLA status: RECRUITING city: Los Angeles state: California zip: 90095 country: United States name: Magdalena Mendez-Smith role: CONTACT phone: 310-267-7727 email: mmendezsmith@mednet.ucla.edu name: Nima Nassiri, MD role: PRINCIPAL_INVESTIGATOR lat: 34.05223 lon: -118.24368 hasResults: False
nctId: NCT06337929 id: Ethics Approval: n. 6.683.936 briefTitle: Effects of Capoeira on the Physical and Psychological Performance of Adults overallStatus: ENROLLING_BY_INVITATION date: 2024-04-01 date: 2024-07-15 date: 2024-12-13 date: 2024-03-29 date: 2024-03-29 name: Universidade Federal do vale do São Francisco class: OTHER briefSummary: Regular physical activity (PA) promotes benefits for both physical and mental health. Among the numerous PA\'s with a collective nature that can add to the existing recommendations, combat sports training interventions are viable alternatives since they integrate benefits in different aspects for health. In this way, capoeira can be a strategy for the prescription of exercise, aiming to serve participants collectively and maintaining the adherence of this practitioner to the intervention. However, little is known about this issue. So, the aim of the present study is to verify the effect of 12 weeks of capoeira training on the physical performance and psychological aspects of previously physically inactive adults. conditions: Training conditions: Mental Health conditions: Physical Fitness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 42 type: ESTIMATED name: CAPOEIRA TRAINING name: CONTROL GROUP measure: Change from baseline in aerobic fitness (maximal oxygen uptake and anaerobic threshold) at week 12 measure: Change from baseline in anaerobic fitness (Peak, average and minimum power in the Wingate test) at week 12 measure: Change from baseline in muscle strength (Horizontal Leg Press) at week 12 measure: Change from baseline in muscle power (Vertical Jump Tests from Squat Jump and Counter Movement Jump) on force platform at week 12 measure: Change from baseline in balance (Center of Pressure) on force platform at week 12 measure: Change from baseline in motor coordination (Test of Gross Motor Development) at week 12 measure: Change from baseline in Emotional Intelligence to sport (Likert-type scales with 26 items) at week 12 measure: Change from baseline in Motivation for Sport II (Likert-type scales with 18 items) at week 12 measure: Change from baseline in Quality of life measuring by Questionnaire of Word Health Organization (WHOQOL-bref) at week 12 sex: ALL minimumAge: 18 Years maximumAge: 59 Years stdAges: ADULT facility: UNIVASF city: Petrolina state: Pernambuco zip: 56300000 country: Brazil lat: -9.39861 lon: -40.50083 hasResults: False
nctId: NCT06337916 id: 2021/16-01 briefTitle: The Effect of Cervical Stabilization Exercises on the Cervical Proprioception in Patients With Chronic Neck Pain overallStatus: COMPLETED date: 2022-10-07 date: 2022-11-25 date: 2023-01-30 date: 2024-03-29 date: 2024-04-02 name: Şenay Özdolap class: OTHER name: Zonguldak Bulent Ecevit University briefSummary: Neck pain is one of the most common musculoskeletal complaints and its prevalence is between 10-22%. Approximately half of all individuals will experience a clinically important neck pain episode over the course of their lifetime. Neck pain is categorized by duration as acute, subacute and chronic neck pain (acute, \<6 weeks; subacute, ≤3 months; chronic, \>3 months). Chronic neck pain is more common in women and its incidence increases with age. Cervical disc herniation, cervical spondylosis, cervical stenosis, myofascial pain syndrome, cervical instability, whiplash injury, Klippel feil syndrome, thoracic outlet syndrome, cervical sprain, cervical strain, tumors, rheumatic diseases, torticollis, inflammatory neck pain are the main causes.
Anterior tilt of the head is a common posture in neck pain. In this posture, the upper cervical vertebrae are extension, the lower cervical vertebrae are flexion and the cervical lordosis is decreased. With neck pain, inhibition occurs in the deep neck flexor (longus coli and capitis) and extensor (multifidus, rotator, semispinalis) muscles, increased fat infiltration, deterioration in type 1 and 2 fiber ratios, and muscle atrophy. The risk of micro and macro trauma increases and muscle support decreases. Thus, there is an increase in the activation response and fatigue of the neck superficial muscle group (trapeze, scalene, sternocleidomastoid muscles), and a decrease in neck joint movement and proprioception sense. As a result, it was determined that there are deficiencies in the sense of proprioception in patients with neck pain.
Studies have shown that many receptors related to the sense of position are on deep cervical flexor muscles such as Musculus Longus Capitis and Musculus Longus Colli. In cases where there are changes such as atrophy and fat infiltration in these muscles, there is a decrease in proprioceptive sensation.Conservative treatment is the first choice in the treatment of neck pain. The important components of this treatment are stretching, strengthening, posture, stabilization, proprioception, relaxation, joint movement exercises and aerobic exercises. The purpose of stabilization exercises, which have been used in the treatment of chronic neck pain recently; to support the vertebral column by activating the stabilizing muscles and to improve posture by increasing kinesthetic awareness.
In this study, between 15 June 2022 and 30 January 2023; 72 volunteers, aged between 18-55 years, with neck pain for more than 3 months, with good cognitive function, who applied to the our Physical Medicine and Rehabilitation Clinic will be included. The patients will be randomized to two groups as cervical stabilization exercise group and conventional cervical exercise treatment group. The patients in group 1 will receive cervical stabilization exercises 1 session a day, 3 days a week for 6 weeks, and the patients in group 2 will perform cervical stabilization exercises for 6 weeks, 3 days a week, 1 session a day. conventional cervical exercises will be given. Patients of both groups will do their exercises in the first 3 weeks accompanied by a physiotherapist, and in the last 3 weeks as a home exercise program.
Demographic information (address, telephone, age, occupation, height, weight, marital status, etc.) of the patients to be included in the study will be recorded and general musculoskeletal examinations will be performed. The patients will be compared to evaluate for Visual Analogue Scale (VAS), Neck Disability Index (NDI) and Short Form-36 (SF-36), cervical range of motion and cervical joint position sense after intervention. Cervical range of motion and cervical joint position sense will be evaluated with the Cervical Range of Motion Deluxe Device (CROM). conditions: Neck Pain conditions: Chronic Neck Pain studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ACTUAL name: Cervical Stabilization Exercise name: Cervical Standard Exercise Group measure: assessment of cervical joint position sense measure: assessment of cervical range of motion measure: assessment of neck disability measure: assessment of pain measure: assessment of life quality sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Zonguldak Bülent Ecevit University city: Zonguldak zip: 67100 country: Turkey lat: 41.45139 lon: 31.79305 hasResults: False
nctId: NCT06337903 id: Self-compassion for PwMS briefTitle: Self-compassion for People With Multiple Sclerosis: An Exploratory Feasibility Study overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-04-30 date: 2025-04-30 date: 2024-03-29 date: 2024-04-01 name: Robert Simpson class: OTHER briefSummary: The goal of this clinical trial is to develop and investigate a compassion-based intervention (Mindful Self-Compassion course) in people with multiple sclerosis. The main objectives are:
Participants will be asked to take part in an 8-week online Mindful Self-Compassion course and report changes in levels of stress, anxiety, depression, self-compassion, adjustment, emotion, and quality of life from pre- to post-intervention and at 3-month follow-up. Additionally, participants will be asked to take part in a semi-structured interview to explore their experiences with the course, perceived effects, and suggestions for improvement. conditions: Multiple Sclerosis conditions: Self-Compassion studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 45 type: ESTIMATED name: Self-compassion intervention (the Mindful Self-Compassion course) measure: Recruitment measure: Retention measure: Adherence measure: Follow-up rates measure: Stress measure: Anxiety measure: Depression measure: Self-compassion measure: Emotion Regulation measure: Quality of Life using the Multiple Sclerosis Impact Scale (MSIS-29) measure: Participant Experiences and Perspectives measure: Adjustment sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Unity Health Toronto city: Toronto country: Canada name: Robert Simpson, PhD role: CONTACT lat: 43.70011 lon: -79.4163 hasResults: False
nctId: NCT06337890 id: FEZECO briefTitle: CO2 Automated Angiographies With Fusion Imaging for Zero- or Near Zero- Contrast FEVAR. overallStatus: RECRUITING date: 2024-01-01 date: 2024-12-31 date: 2024-12-31 date: 2024-03-29 date: 2024-03-29 name: University of Bologna class: OTHER briefSummary: Fenestrated endovascular aneurysm repair (FEVAR) is an established technique used to treat complex aortic aneurysms (TAAAs), with satisfactory early and midterm results.
The aim of the present study is to report the possibility to combine the use of automated CO2 angiographies and Fusion Imaging to obtain zero- or near zero- contrast FEVAR for complex aortic aneurysms. conditions: Aortic Aneurysm studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 40 type: ESTIMATED name: Zero contrast FEVAR measure: Rate of technical success measure: Reintervention and mortality measure: Number of participants with perioperative renal function worsening measure: Rate of TVVs instability measure: Rate of survival measure: Rate of reintervention measure: Number of participants with renal function worsening sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Bologna status: RECRUITING city: Bologna state: Emilia Romagna zip: 40138 country: Italy name: Enrico Gallitto, MD, PhD role: CONTACT phone: +390512143288 email: enrico.gallitto@gmail.com lat: 44.49381 lon: 11.33875 hasResults: False