hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06361121 id: D361 briefTitle: Mid-point Transverse Process to Pleura Block Versus Thoracic Paravertebral Block in Posterolateral Thoracotomy overallStatus: RECRUITING date: 2024-03-01 date: 2025-03 date: 2025-03 date: 2024-04-11 date: 2024-04-11 name: Fayoum University Hospital class: OTHER briefSummary: The ultrasound guided Thoracic paravertebral (TPV) block in the context of posterolateral thoracotomy offers targeted pain relief by anesthetizing the spinal nerves as they emerge from the intervertebral foramina, producing ipsilateral somatosensory, visceral and sympathetic nerve blockade. TPV block involves the injection of local anesthetic (LA) into the wedge-shaped paravertebral space deep to the superior costotransverse ligament (SCTL)
In our study we hypothesized that the mid-point transverse process to pleura (MTP) block can provide an effective analgesia comparable with thoracic paravertebral (TPV) block in adult patients undergoing posterolateral thoracotomy incisions. conditions: Bronchiectasis conditions: Lung Neoplasm conditions: Emphysematous Bleb of Lung studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: The patients will be randomized into two groups: MTP block group and TPV block group in a 1:1 ratio using a computer-generated random table. The patient's assigned group information will be elicited from a sealed opaque envelope by the anesthesiologist who will perform the US-guided MTP and TPV block and will not be involved in further data collection or patient care. The patients and both the surgical and anesthesia teams, who are responsible for patient care and data collection are blinded from the group assignments whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 180 type: ESTIMATED name: mid-point transverse process to pleura (MTP) block name: Thoracic Paravertebral Block measure: The total postoperative fentanyl consumption measure: Demographic data measure: visual analogue scale score both during rest and with cough measure: intra operative fentanyl consumption measure: Duration of surgery measure: Blood pressure measure: Heart rate measure: Oxygen saturation measure: complications related to the block measure: complications related to IV opioids measure: Hospital length of stay in days measure: Participant satisfaction sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fayoum University Hospital status: RECRUITING city: Fayoum zip: 63514 country: Egypt name: Mohamed A Hamed, MD role: CONTACT phone: 01010509736 phoneExt: +20 email: mah07@fayoum.edu.eg name: Mohamed A Hamed, MD role: PRINCIPAL_INVESTIGATOR lat: 29.30995 lon: 30.8418 hasResults: False
nctId: NCT06361108 id: YJ001-103 briefTitle: Multiple-Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of YJ001 for Spray Use in Patients With Diabetic Peripheral Neuropathic Pain overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2025-03-20 date: 2025-03-20 date: 2024-04-11 date: 2024-04-11 name: Zhejiang Hanmai Pharmaceutical Technology Co., Ltd. class: INDUSTRY briefSummary: This Phase I, randomized, double-blind and placebo controlled study is to evaluate the safety, tolerability, and PK, and to preliminarily assess the efficacy of topically administered YJ001 in a multiple-ascending dose (MAD) fashion in the patients with DPNP. The study will be conducted at a single study center.
Each subject will be administered a single dose of YJ001 as multiple sprays topically on both feet and below the ankle in the morning on Day 1 and Day 2, and will be administered as twice daily doses once in the morning and the other in the evening (with an interval of 11 to 13 h) from Day 3 through Day 11. conditions: Diabetic Peripheral Neuropathic Pain studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Double-blinded with regard to the study treatment that subjects receive,without the investigator, the sponsor, or the subjects being aware of wether YJ001 or the placebo is administered. All decisions concerning dose escalation will be made in a blinded manner by the safety review committee.
The SRC will determine whether to proceed to the next planned dose level, continue with the study and add additional safety evaluations, expand the number of subjects at the current level, reduce the dose, or stop the study. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: YJ001 for Spray Use name: Placebo of YJ001 for Spray Use measure: Safety Assessments - AEs measure: Safety Assessments -Number of Participants With Abnormal Laboratory Values measure: Safety Assessments - Skin Reaction measure: Pharmacokinetics-AUC measure: Pharmacokinetics- Cmax measure: Pharmacokinetics - tmax measure: Pharmacokinetics - tlag measure: Pharmacokinetics - t1/2 measure: Pharmacokinetics - CLr/f,ss measure: Efficacy evaluation indicator measure: Efficacy evaluation indicators - ADSIS measure: Efficacy evaluation indicators - SF-MPQ measure: Efficacy evaluation indicators - VPT sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clinical Trials of Texas,LLC city: Fredericksburg state: Texas zip: 78229 country: United States name: Douglas Scott Denham role: CONTACT phone: 210-949-0122 lat: 30.2752 lon: -98.87198 hasResults: False
nctId: NCT06361095 id: R01GABM briefTitle: Confirmatory Efficacy Trial of Attention Bias Modification for Depression overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2028-03-01 date: 2028-03-01 date: 2024-04-11 date: 2024-04-16 name: University of Texas at Austin class: OTHER name: Arcade Therapeutics briefSummary: The goal of this clinical trial is to compare the efficacy of two related, but different ABM (Attention Biased Modification) treatments for depression in adults with elevated symptoms of depression. The main aims are:
If there is a comparison group: Researchers will compare sham, traditional, and gamified treatment groups to see if they moderate symptoms of depression. conditions: Depression studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 600 type: ESTIMATED name: Traditional Attention Bias Modification name: Gamified Attention Bias Modification name: Sham Attention Bias Modification measure: QIDS (Quick Inventory of Depression Symptoms) SR-16 measure: Sheehan Disability Scale (SDS) measure: Snaith-Hamilton Pleasure Scale (SHAPS) measure: Hamilton Depression Rating Scale (HAM-D) measure: Generalized Anxiety Disorder (GAD-7) measure: Perseverative Thinking Questionnaire (PTQ) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Institute for Mental Health Research city: Austin state: Texas zip: 78705 country: United States name: Christopher G Beevers, PhD role: CONTACT email: beevers@utexas.edu role: CONTACT email: beevers@utexas.edu lat: 30.26715 lon: -97.74306 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-04-05 uploadDate: 2024-04-08T12:13 filename: ICF_000.pdf size: 143608 hasResults: False
nctId: NCT06361082 id: CORPG5N0061 briefTitle: Ultrasonic Backscatter Imaging for ACL Reconstruction and Shoulder Diseases overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-10 date: 2025-10 date: 2024-04-11 date: 2024-04-11 name: Chang Gung Memorial Hospital class: OTHER briefSummary: This study explores ultrasonic scattering imaging technology in patients undergoing anterior cruciate ligament (ACL) reconstruction and those with shoulder musculoskeletal disorders. Ultrasonography, widely utilized for diagnosing musculoskeletal conditions, faces limitations due to factors like operator experience and equipment settings, often lacking in quantifiable disease metrics. Nakagami imaging, employing the backscattering statistical distribution model, offers a quantitative assessment method that minimizes subjective interpretation by extracting tissue properties through the interaction between ultrasound and tissue microstructure. The Nakagami model effectively describes tissue scattering statistics, enabling the identification and classification of tissue features based on specific scattering conditions.
ACL reconstruction is commonly performed, with postoperative complications including joint stiffness and muscle strength decline, associated with changes in muscle quality and volume. Similarly, soft tissue injuries around the shoulder and ankle are prevalent in sports medicine, with ultrasound used to assess the severity of injuries to soft tissues such as the rotator cuff tendons/muscles and surrounding ligaments of the shoulder, as well as the medial and lateral ligament complexes of the ankle. Preliminary findings suggest that Nakagami imaging can differentiate layers within normal tendons, proposing its potential for visualizing and quantifying soft tissue lesions post-ultrasound, aiming for standardized diagnostic criteria.
The results of this project could significantly improve the diagnostic efficacy of musculoskeletal ultrasound, facilitating earlier treatment and reducing the socio-economic impacts. Academically, it positions the investigating team as pioneers in the application of ultrasound inverse scattering imaging technology. conditions: ACL Injury conditions: ACL Reconstruction studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: ACL reconstruction measure: MRI of affected limb- Cross sectional area measured in squared cm of quadriceps muscles measure: Ultrasound Nakagami back scattering analysis- Nakagami index measure: Physical examination of limbs- Angles of Range of Motion of knee measure: MRI of affected limb- Quality of knee structures documented with descriptions for MR signals measure: Physical examination of limbs- Laxity of knee ligaments of subjects number with any positive knee physical findings measure: Ultrasound of affected limb- Cross sectional area measured in squared cm of quadriceps muscles measure: Ultrasound of affected limb- Quality of knee structures documented with descriptions for echogenicity sex: ALL minimumAge: 20 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06361069 id: aslıakdeniz briefTitle: Reducing Anxiety in Children Undergoing Day Surgery overallStatus: COMPLETED date: 2023-04-01 date: 2023-08-01 date: 2024-01-01 date: 2024-04-11 date: 2024-04-11 name: Bilecik Seyh Edebali Universitesi class: OTHER briefSummary: Aim: This study was conducted to determine the efﬁcacy of finger puppets, distraction cards and kaleidoscope for reducing anxiety in children undergoing day surgery.
Methods: The study was conducted using the "pre-post test unmatched group model", one of the quasi-experimental methods. The study was conducted between April 2023 and January 2024 with children aged 6-12 years who were admitted to the pediatric clinic of a hospital for day surgery. A total of 85 children (including 20 children in the control group, 22 children in the finger puppet intervention group, 21 children in the distraction cards intervention group, and 22 children in the kaleidoscope intervention group) who were hospitalized in the pediatric clinic between April 2023 and January 2024 and who met the inclusion criteria were included in the study. Descriptive statistics, Mann Whitney U test, Kruskal Wallis and regression analysis were used in the evaluation of the data. conditions: Anxiety conditions: Child, Only conditions: Surgery studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study was conducted using the "pre-post test unpaired group model", one of the quasi-experimental methods. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 85 type: ACTUAL name: distraction cards, kaleidoscope and finger puppet measure: Anxiety sex: ALL minimumAge: 6 Years maximumAge: 12 Years stdAges: CHILD facility: Bilecik Şeyh Edebali University city: Bilecik country: Turkey lat: 40.14192 lon: 29.97932 hasResults: False
nctId: NCT06361056 id: LCCC2140 briefTitle: Mobile Health App to Promote Participation of Black Women in Breast Cancer Clinical Trials overallStatus: RECRUITING date: 2022-05-02 date: 2025-01 date: 2026-01 date: 2024-04-11 date: 2024-04-17 name: UNC Lineberger Comprehensive Cancer Center class: OTHER briefSummary: This study explores the overall feasibility, impact, and satisfaction of using the "mHealth app" on clinic workflow for Black or African American women diagnosed with breast cancer.
The "mHealth app" which can be used as a platform to share clinical trial education and communication, was created and tested in previous steps of this study. conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 80 type: ESTIMATED name: Survey name: mHealth app measure: Feasibility of Mobile Health Application (mHealth app)- subjects measure: Feasibility of Mobile Health Application (mHealth app) - Clinicians and staff measure: Overall satisfaction sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UNC Lineberger Comprehensive Cancer Center status: RECRUITING city: Chapel Hill state: North Carolina zip: 27514 country: United States name: Lauren Matthews role: CONTACT phone: 919-843-5321 email: lauren_matthews@med.unc.edu name: Marjory Charlot, MD, MPH, MSc role: PRINCIPAL_INVESTIGATOR lat: 35.9132 lon: -79.05584 hasResults: False
nctId: NCT06361043 id: 2023-01833 briefTitle: Conebeam CT-based Online Adaptive Radio-Therapy for Esophageal Cancer (ARTEC) acronym: ARTEC overallStatus: RECRUITING date: 2024-04-20 date: 2027-02-28 date: 2027-02-28 date: 2024-04-11 date: 2024-04-25 name: Insel Gruppe AG, University Hospital Bern class: OTHER briefSummary: Despite multimodal therapy, patients with esophageal cancer have poor prognosis with 5-year overall survival around 25%. Considering tumor-related death as main reason for high mortality rate in those patients, treatment-related cardio-pulmonary toxicities could also play a role in this regard. Online adaptive radiotherapy offers the possibility for daily re-planning and therefore helps radiation oncologists to better spare the organs at risk and reduce radiation-induced toxicity. Tha aim of ARTEC is to assess the pulmonary toxicity in patients with esophageal cancer treated with online adaptive radiotherapy. conditions: Esophageal Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 30 type: ESTIMATED measure: Number of patients with pulmonary toxicity measure: Number of patients with pathological complete response measure: Dosimetrical analysis between scheduled and adaptive plans sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Inselspital, University of Berne, Deparftment of Radio-Oncology status: RECRUITING city: Berne zip: 3010 country: Switzerland name: Hossein Hammatazad, MD role: CONTACT phone: +41 31 632 26 32 email: hossein.hemmatazad@insel.ch name: Timo Nannen role: CONTACT phone: +41 31 632 90 74 email: timo.nannen@insel.ch lat: 46.94809 lon: 7.44744 hasResults: False
nctId: NCT06361030 id: HMPL-012-C2-PC01 briefTitle: Surufatinib Combined With Gemcitabine Plus Nab-paclitaxel in Locally Advanced Pancreatic Cancer overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-06-01 date: 2027-06-01 date: 2024-04-11 date: 2024-04-11 name: Wuhan Union Hospital, China class: OTHER briefSummary: To evaluate the efficacy and safety of surufatinib combined with gemcitabine plus nab-paclitaxel in patients with locally advance d pancreatic cancer conditions: Pancreatic Cancer conditions: Pancreatic Cancer Non-resectable conditions: Pancreatic Ductal Adenocarcinoma, PDAC studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: surufatinib combined with gemcitabine plus nab-paclitaxel measure: Surgical conversion rate measure: Objective Response Rate (ORR) measure: Disease control rate (DCR) measure: R0 surgical conversion rate measure: progression free survival(PFS) measure: Overall Survival (OS) measure: Adverse Event sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology city: Wuhan state: Hubei zip: 430000 country: China name: Heshui Wu role: CONTACT phone: +86 137-2011-7761 email: heshuiwu@hust.edu.cn name: Heshui Wu role: PRINCIPAL_INVESTIGATOR lat: 30.58333 lon: 114.26667 hasResults: False
nctId: NCT06361017 id: QNPY2022007 briefTitle: The Prediction of Hemorrhage Transformation by Cerebral Autoregulation in AIS Patient After Endovascular Thrombectomy acronym: PHASE overallStatus: ENROLLING_BY_INVITATION date: 2022-03-01 date: 2025-03-01 date: 2026-03-01 date: 2024-04-11 date: 2024-04-11 name: Xuanwu Hospital, Beijing class: OTHER briefSummary: This observational study was designed for observe the cerebral hemodynamics and dynamic cerebral autoregulation (dCA) after endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) patients. And analysis the relationship between the dCA damage degree and hemorrhage transformation (HT) and clinical outcome.
The objectives of the study were as follows: The changes of cerebral hemodynamics and parameters of dCA in different time periods after EVT were analyzed. So as to determine the correlation between hemodynamics and dCA change and HT and clinical outcome after EVT and to explore the predictors of HT and adverse clinical outcomes. conditions: Acute Ischemic Stroke conditions: Endovascular Thrombectomy conditions: Dynamic Cerebral Autoregulation studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 300 type: ESTIMATED name: endovascular thrombectomy measure: The occurrence of hemorrhage transformation measure: Patients without hemorrhage transformation measure: The occurrence of unfavorable outcome measure: The occurrence of favorable outcome measure: The occurrence of long-term unfavorable outcome measure: The occurrence of long-term favorable outcome sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Vascular Ultrasonography, Xuanwu Hospital of Capital Medical University city: Beijing state: Beijing zip: 100053 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06361004 id: DBS for TR-TS briefTitle: Exploring DBS Efficacy in Treatment-refractory Tourette's Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2028-12-31 date: 2029-12-31 date: 2024-04-11 date: 2024-04-11 name: Xuanwu Hospital, Beijing class: OTHER briefSummary: The primary purpose of this study is to investigate the effect of deep brain stimulation (DBS) in patients with Treatment-refractory Tourette's syndrome (TR-TS) implantation targeting the Antero-medial globus pallidus interna (GPi), Antero-medial globus pallidus interna (amGPi), Postero-ventrolateral GPi (pvGPi), Centromedian nucleus, substantia periventricularis and nucleus ventro-oralis internus (Cm-Spv-Voi), Centre median nucleus and nucleus ventro-oralis (Cm-Voi), or Nucleus Accumbens/ Anterior Limb of Internal Capsule (NA-ALIC), or other unreported nuclei targets. conditions: Tourette's Syndrome studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Patients with Treatment-refractory Tourette's syndrome (TR-TS) primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Deep Brain Stimulation (DBS) measure: Yale Global Tic Severity Scale (YGTSS): Reduction in total tics on the YGTSS after 6 months measure: YGTSS-Total Motor: Change in YGTSS-Total Motor at week 2, month 3, month 6, and month 12. measure: YGTSS-Total Phonic: Change in YGTSS-Total phonic at week 2, month 3, month 6, and month 12. measure: YGTSS: remission, and response rate measure: Yale-Brown Obsessive Compulsive Scale (Y-BOCS): Change in Y-BOCS at week 2, month 3, month 6, and month 12. measure: Hamilton Anxiety Scale (HAMA): the change from baseline to 2 weeks, 3 months, 6 months, and 12 months in the HAMA total score. measure: Hamilton Depression Rating Scale (HAMD-17): the changes of HAMD-17 scores and its subscales from baseline to 2 weeks, 3 months, 6 months, and 12 months. measure: Pittsburgh Sleep Quality Index (PSQI): the change of PSQI from baseline to Week 2, Month 3, Month 6, and Month 12. measure: Clinical Global Impression-Severity (CGI-S): the change from baseline to 2 weeks, 3 months, 6 months, and 12 months in Clinical Global Impression-Severity (CGI-S) measure: Clinical Global Impression-Improvement (CGI-I): CGI-I score at Week 2, Month 1, Month 3, Month 6, and Month 12. measure: EuroQol-5 Dimension-level Scale (EQ-5D-5L): the change from baseline to Week 2, Month 3, Month 6, and Month 12 in EQ-5D-5L. measure: Young Mania Rating Scale (YMRS): the change from baseline to Week 2, Month 1, Month 3, Month 6, and Month 12. measure: Safety as indicated by the number of Adverse Events: Week 2, Month 3, Month 6, and Month 12. measure: Change from baseline in the Verbal Fluency Test (COWAT) measure: Change from baseline in the Trailmaking Test A&B measure: Change in Rey-Osterrieth Complex Figure Test sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Xuanwu Hospital, Capital Medical University city: Beijing zip: 100053 country: China lat: 39.9075 lon: 116.39723 hasResults: False