Moreover, Regorafenib showed good efficacy in different cancer types, such as colorectal cancer, GIST, hepatocellular carcinoma and glioblastoma (REGOMA trial) , maintainingmaintaining a good quality of life. conditions: Meningioma, Malignant studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 104 type: ESTIMATED name: Regorafenib 40 MG Oral Tablet name: Local Standard of Care measure: Progression free survival (PFS) measure: Overall survival (OS) measure: Objective response rate (ORR) measure: Patient Reported Outcomes (PROs) measure: Patient Reported Outcomes (PROs) measure: Toxicity during treatment measure: Disease control rate (DCR) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRST Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" city: Meldola state: Forlì-Cesena country: Italy name: Lorena Gurrieri, MD role: CONTACT email: lorena.gurrieri@irst.emr.it name: Lorena Gurrieri, MD role: PRINCIPAL_INVESTIGATOR lat: 44.12775 lon: 12.0626 facility: Humanitas Cancer Center city: Rozzano state: Milano country: Italy name: Matteo Simonelli, MD role: CONTACT email: matteo.simonelli@hunimed.eu name: Matteo Simonelli, MD role: PRINCIPAL_INVESTIGATOR lat: 45.38193 lon: 9.1559 facility: Ospedale San Paolo city: Bari country: Italy name: Valeria Internò, MD role: CONTACT email: valeria.interno@libero.it name: Valeria Internò, MD role: PRINCIPAL_INVESTIGATOR lat: 41.11148 lon: 16.8554 facility: Ospedale Bellaria - AUSL Bologna city: Bologna country: Italy name: Enrico Franceschi, MD role: CONTACT email: e.franceschi@isnb.it name: Enrico Franceschi, MD role: PRINCIPAL_INVESTIGATOR lat: 44.49381 lon: 11.33875 facility: Azienda Ospedaliero Universitaria Careggi city: Firenze country: Italy name: Isacco Desideri, MD role: CONTACT email: isacco.desideri@unifi.it name: Isacco Desideri, MD role: PRINCIPAL_INVESTIGATOR lat: 43.77925 lon: 11.24626 facility: Policlinico San Martino city: Genova country: Italy name: Elisa Bennicelli, MD role: CONTACT email: elisa.bennicelli@hsanmartino.it name: Elisa Bennicelli, MD role: PRINCIPAL_INVESTIGATOR lat: 44.40478 lon: 8.94438 facility: Spedali Riuniti city: Livorno country: Italy name: Anna Luisa Di Stefano, MD role: CONTACT email: annaluisa.distefano@uslnordovest.toscana.it name: Anna Luisa Di Stefano, MD role: PRINCIPAL_INVESTIGATOR lat: 43.54427 lon: 10.32615 facility: Azienda Ospedaliero Universitaria G. Martino city: Messina country: Italy name: Nicola Silvestris, MD role: CONTACT email: n.silvestris@unime.it name: Nicola Silvestris, MD role: PRINCIPAL_INVESTIGATOR lat: 38.19394 lon: 15.55256 facility: Fondazione IRCCS Istituto Neurologico Carlo Besta city: Milano country: Italy name: Paola Gaviani, MD role: CONTACT email: paola.gaviani@istituto-besta.it name: Paola Gaviani, MD role: PRINCIPAL_INVESTIGATOR lat: 45.46427 lon: 9.18951 facility: IRCCS Ospedale San Raffaele city: Milano country: Italy name: Giulia Berzero, MD role: CONTACT email: berzero.giulia@hsr.it name: Giulia Berzero, MD role: PRINCIPAL_INVESTIGATOR lat: 45.46427 lon: 9.18951 facility: Ospedale del Mare city: Napoli country: Italy name: Bruno Daniele, MD role: CONTACT email: b.daniele@libero.it name: Bruno Daniele, MD role: PRINCIPAL_INVESTIGATOR lat: 40.85216 lon: 14.26811 facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS city: Roma country: Italy name: Silvia Chiesa, MD role: CONTACT email: silvia.chiesa@policlinicogemelli.it name: Silvia Chiesa, MD role: PRINCIPAL_INVESTIGATOR lat: 41.89193 lon: 12.51133 facility: IRCCS Istituto Tumori Regina Elena city: Roma country: Italy name: Veronica Villani, MD role: CONTACT email: veronica.villani@ifo.it name: Veronica Villani, MD role: PRINCIPAL_INVESTIGATOR lat: 41.89193 lon: 12.51133 facility: Policlinico Umberto I - Università Sapienza Roma city: Roma country: Italy name: Giuseppe Minniti, MD role: CONTACT email: giuseppe.minniti@uniroma1.it name: Giuseppe Minniti, MD role: PRINCIPAL_INVESTIGATOR lat: 41.89193 lon: 12.51133 facility: A.O.U. Città della Salute e della Scienza di Torino city: Torino country: Italy name: Roberta Rudà, MD role: CONTACT email: roberta.ruda@unito.it name: Roberta Rudà, MD role: PRINCIPAL_INVESTIGATOR lat: 45.07049 lon: 7.68682 hasResults: False