However, the efficacy of ICIs varies from one cancer to another. In addition to the expression of PDL1 by the tumour and/or immune cells, and the mutational load, one of the primary factors predicting response to immunotherapy mentioned in several studies is microsatellite instability (MSI). conditions: Colorectal Cancer Metastatic conditions: Microsatellite Instability-High Colorectal Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 600 type: ESTIMATED measure: Identification of predictive factors of resistance to pembrolizumab immunotherapy in first-line treatment of unresectable mRCC sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ch - Centre Hospitalier de La Côte Basque status: NOT_YET_RECRUITING city: Bayonne CEDEX zip: 64100 country: France name: Franck AUDEMAR, Dr role: CONTACT phone: +33 5 59 44 37 22 email: faudemar@ch-cotebasque.fr name: Anne GUILNGAR, Dr role: CONTACT phone: +33 5 59 44 37 22 email: aguilngar@ch-cotebasque.fr name: Franck AUDEMAR, Dr role: PRINCIPAL_INVESTIGATOR lat: 43.48333 lon: -1.48333 facility: Ch - Ch Beauvais status: NOT_YET_RECRUITING city: Beauvais country: France name: Fayçal HOCINE role: CONTACT phone: 03 44 11 23 09 email: f.hocine@ch-beauvais.fr ; fayoncologie@yahoo.fr lat: 49.43333 lon: 2.08333 facility: CH Jean Minjoz status: NOT_YET_RECRUITING city: Besançon zip: 25030 country: France name: Stéfano KIM, Dr role: CONTACT email: alrollin@chu-besancon.fr lat: 47.24878 lon: 6.01815 facility: Polyclinique Saint Privat status: RECRUITING city: Boujan-sur-Libron zip: 34760 country: France name: Michaël HUMMELSBERGER, Dr role: CONTACT email: michael.hummelsberger@orange.fr lat: 43.36996 lon: 3.24759 facility: Ch - Duchenne status: NOT_YET_RECRUITING city: Boulogne-sur-Mer country: France name: Vincent BOURGEOIS role: CONTACT phone: 06 84 88 43 37 email: vincebourgeois@hotmail.com name: Vincent BOURGEOIS role: PRINCIPAL_INVESTIGATOR lat: 50.71667 lon: 1.61667 facility: Ch - Centre Hospitalier Metropole Savoie status: NOT_YET_RECRUITING city: Chambéry CEDEX zip: 73011 country: France name: Olivier BERTHELET, Dr role: CONTACT phone: 0479965087 email: olivier.berthelet@ch-metropole-savoie.fr name: Tarik HABET, Arc Étude role: CONTACT phone: 0479965910 email: tarik.habet@ch-metropole-savoie.fr name: Olivier BERTHELET, Dr role: PRINCIPAL_INVESTIGATOR lat: 45.56667 lon: 5.93333 facility: Ch - Centre Hospitalier de Cholet status: NOT_YET_RECRUITING city: Cholet zip: 49300 country: France name: You-Heng LAM, Dr role: CONTACT phone: 02 41 49 66 79 email: you-heng.lam@ch-cholet.fr name: Laura VALLEE, Arc Étude role: CONTACT phone: 02 41 49 69 91 email: laura.vallee@ch-cholet.fr name: You-Heng LAM, Dr role: PRINCIPAL_INVESTIGATOR lat: 47.06667 lon: -0.88333 facility: CH - Compiegne status: NOT_YET_RECRUITING city: Compiègne country: France name: Virginie SEBBAGH role: CONTACT phone: 0344236278 email: v.sebbagh@compiegnenoyon.fr name: Virginie SEBBAGH role: PRINCIPAL_INVESTIGATOR lat: 49.41794 lon: 2.82606 facility: Ch - Chd Vendée status: NOT_YET_RECRUITING city: La Roche-sur-Yon zip: 85925 country: France name: Margot LALY, Dr role: CONTACT phone: +33 2 51 44 61 68 email: margot.laly@chd-vendee.fr name: Paul GIROT, Dr role: CONTACT phone: +33 2 51 44 61 68 email: paul.girot@chd-vendee.fr name: Margot LALY, Dr role: PRINCIPAL_INVESTIGATOR lat: 46.66667 lon: -1.43333 facility: CH - Louis Pasteur status: NOT_YET_RECRUITING city: Le Coudray country: France name: Sylvie APRELON role: CONTACT phone: 0237303030 email: saprelon@ch-chartres.fr lat: 48.42115 lon: 1.50057 facility: Centre Hospitalier Regional et Universitaire de Lille status: RECRUITING city: Lille zip: 59037 country: France name: ANTONY TURPIN, MD role: CONTACT phone: 0320445461 lat: 50.63297 lon: 3.05858 facility: CH Saint Joseph - Saint Luc status: NOT_YET_RECRUITING city: Lyon zip: 69365 country: France name: Denis PERE VERGE, Dr role: CONTACT email: dpereverge@ch-stjoseph-stluc-lyon.fr; fannydenis@sfr.fr lat: 45.74848 lon: 4.84669 facility: Caluire et Cuire - Infirmerie Protestante de Lyon status: NOT_YET_RECRUITING city: Lyon country: France name: Johannes HARTWIG role: CONTACT email: johannes.hartwig@infirmerie-protestante.com name: Johannes HARTWIG role: PRINCIPAL_INVESTIGATOR name: David TAVAN role: SUB_INVESTIGATOR lat: 45.74848 lon: 4.84669 facility: Ch - Hôpital Saint Joseph status: NOT_YET_RECRUITING city: Marseille zip: 13285 country: France name: Hervé PERRIER, Dr role: CONTACT phone: 0491808211 email: hperrier@hopital-saint-joseph.fr name: Christelle BASTHISTE-PELE, Dr role: CONTACT phone: 0491808203 email: cbasthiste@hopital-saint-joseph.fr name: Hervé PERRIER, Dr role: PRINCIPAL_INVESTIGATOR name: Christelle BASTHISTE-PELE, Dr role: SUB_INVESTIGATOR name: Patrick BEAURAIN, Dr role: SUB_INVESTIGATOR name: Hélène BRUNETEAU, Dr role: SUB_INVESTIGATOR name: Aurélie CAMOIN, Dr role: SUB_INVESTIGATOR name: Annick CHICOUENE-BRUNELLE, Dr role: SUB_INVESTIGATOR name: Christophe LAPLACE, Dr role: SUB_INVESTIGATOR name: Nadjet SAADALLAH-BOUCHEMOT, Dr role: SUB_INVESTIGATOR lat: 43.29551 lon: 5.38958 facility: CH Saint Joseph status: NOT_YET_RECRUITING city: Marseille country: France name: Hervé PERRIER role: CONTACT email: recherche-clinique@infirmerie-protestante.com; herve.perrier@infirmerie-protestante.com name: Hervé PERRIER role: PRINCIPAL_INVESTIGATOR name: Xavier ADHOUTE role: SUB_INVESTIGATOR lat: 43.29551 lon: 5.38958 facility: Centre Hospitalier status: NOT_YET_RECRUITING city: Mulhouse zip: 68070 country: France name: D. 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Vedrenne, MD role: CONTACT phone: 33-3-8964-7049 lat: 47.75 lon: 7.33333 facility: CHR D'Orleans - Hopital de la Source status: NOT_YET_RECRUITING city: Orleans zip: 45100 country: France name: Jean-Paul Lagasse role: CONTACT phone: 33-02-3651-4704 lat: 47.90289 lon: 1.90389 facility: Prive - Institut Montsouris status: RECRUITING city: Paris country: France name: Raphael COLLE role: CONTACT phone: 0156616035 email: raphael.colle@imm.fr name: Emilie SOULARUE role: CONTACT phone: 0633312811 email: emilie.solarue@aphp.fr name: Christophe LOUVET role: PRINCIPAL_INVESTIGATOR lat: 48.85341 lon: 2.3488 facility: Ch - Centre Hospitalier de Soisson status: NOT_YET_RECRUITING city: Soissons CEDEX zip: 02209 country: France name: Sarah MONTEMBAULT, Dr role: CONTACT phone: 0326966859 email: sarah.montembault@ch-soissons.fr name: Valérie PANIS, Arc Étude role: CONTACT phone: 0322824002 email: paris.valerie@chu-amiens.fr name: Sarah MONTEMBAULT, Dr role: PRINCIPAL_INVESTIGATOR lat: 49.38167 lon: 3.32361 facility: CH - Gustave Dron status: NOT_YET_RECRUITING city: Tourcoing country: France name: Loïc LEBELLEC role: CONTACT phone: 0320694488 email: llebellec@ch-tourcoing.fr name: Floriane RICHA role: CONTACT phone: 0320694949 email: fverhaeghe@ch-tourcoing.fr name: Loïc LEBELLEC role: PRINCIPAL_INVESTIGATOR lat: 50.72391 lon: 3.16117 hasResults: False