nctId: NCT06381180 id: Warrior CARE: CBH briefTitle: Warrior CARE: Cannabis Behavioral Health acronym: CBH overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2030-12-31 date: 2030-12-31 date: 2024-04-24 date: 2024-04-24 name: Wayne State University class: OTHER briefSummary: This study is a randomized, controlled clinical trial to examine the therapeutic potential of cannabinoids for treating veterans with PTSD and suicidal ideation. conditions: Post Traumatic Stress Disorder conditions: Cannabis Use conditions: Suicide conditions: Veterans conditions: Marijuana studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 500 type: ESTIMATED name: Tetrahydrocannabinol name: Cannabidiol name: Placebo measure: Assessing change in PTSD diagnosis and its symptom severity from pre-treatment to post-treatment using the CAPS-5 assessment. measure: Assessing change in PTSD diagnosis and its symptom severity throughout the study using the PCL-5 assessment measure: Assessing Suicidality over time using the C-SSRS assessment. measure: Assessing Suicidality throughout the study using the SBQ-R assessment. measure: Assessing mood and anxiety symptoms throughout the study using the BDI-II and STAI-Y Questionnaires. measure: Assess emotional state pre- and post-treatment using the PANAS questionnaire. measure: Assess feelings of loneliness pre- and post-treatment using UCLA's 3-ILS assessment. measure: Assess childhood and lifetime trauma pre- and post-treatment using the ACE, CTQ, and PCTI questionnaires. measure: Assess dissociative symptoms pre- and post-treatment using the MDI and DSS assessments. measure: Assess drug effects, liking, and symptoms after cannabis administration using the SCERF and SES visual analog scales. measure: Assess ethnic-racial discrimination pre- and post-treatment using the CERIS-A and TSDS Questionnaires. measure: Assess demographics using a self-report assessment measure: Assess toxicant exposure commonly experienced during war using the KGWIC and BPE assessments. measure: Assess smoking habits and history using the FTND assessment measure: Assess general health and history pre- and post-treatment using the SF-36 assessment. measure: Assess healthcare utilization throughout the study. measure: Assess pain pre- and post-treatment using the BPI assessment. measure: Assess sleepiness pre- and post-treatment using the ESS questionnaire. measure: Assess overall quality of life pre- and post-treatment using the QOL questionnaire. measure: Assess substance use throughout the study using the TLFB assessment. measure: Assess neurocognitive and executive function pre- and post-treatment using the WCST, WMS, CVLT, HMDD, WCS, IGT tasks measure: Assess physiological measures throughout the study as a safety check measure: Assess biological samples for genetic markers associated with the endocannabinoid system and other biomarkers (e.g., cortisol) and measure THC and CBD. sex: ALL minimumAge: 19 Years maximumAge: 69 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Wayne State University city: Detroit state: Michigan zip: 48201 country: United States name: Nareen Sadik, B.S. role: CONTACT lat: 42.33143 lon: -83.04575 hasResults: False