nctId: NCT06380335 id: RTX001-01S briefTitle: Study in Patients With Decompensated Liver Cirrhosis acronym: OPAL overallStatus: RECRUITING date: 2023-10-10 date: 2024-12-31 date: 2026-11-03 date: 2024-04-23 date: 2024-04-23 name: Resolution Therapeutics Limited class: NETWORK briefSummary: OPAL is a multicenter observational study, following the natural disease trajectory of participants who have permanent damage to their liver caused by scarring, sometimes also referred to as liver cirrhosis. These participants will also have recently had an acute worsening of their liver disease, which is also known as a hepatic decompensating event, which has resulted in them being admitted to hospital or required them to seek medical attention as an outpatient. conditions: Liver Cirrhosis studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 240 type: ESTIMATED measure: Examine the characteristics of patients admitted to hospital with hepatic decompensation. measure: Examine the characteristics of patients admitted to hospital with hepatic decompensation. measure: Examine the characteristics of patients admitted to hospital with hepatic decompensation. measure: Examine the characteristics of patients admitted to hospital with hepatic decompensation. measure: Examine the characteristics of patients admitted to hospital with hepatic decompensation. measure: Examine the characteristics of patients admitted to hospital with hepatic decompensation. measure: Follow the natural history of patients admitted to hospital with hepatic decompensation. measure: Follow the natural history of patients admitted to hospital with hepatic decompensation. measure: Follow the natural history of patients admitted to hospital with hepatic decompensation. measure: Follow the natural history of patients admitted to hospital with hepatic decompensation. measure: Examine the characteristics and natural history of patients with medically refractory ascites that do not require hospitalisation. measure: Examine the characteristics and natural history of patients with medically refractory ascites that do not require hospitalisation. measure: Examine the characteristics and natural history of patients with medically refractory ascites that do not require hospitalisation. measure: Examine the characteristics and natural history of patients with medically refractory ascites that do not require hospitalisation. measure: Examine the characteristics and natural history of patients with medically refractory ascites that do not require hospitalisation. measure: Examine the characteristics and natural history of patients with medically refractory ascites that do not require hospitalisation. measure: Examine the characteristics and natural history of patients with medically refractory ascites that do not require hospitalisation. measure: Explore clinical and laboratory parameters. measure: Evaluate the effect of disease progression on biomarkers of inflammatory activity sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bristol Royal Infirmary status: RECRUITING city: Bristol zip: BS2 8HW country: United Kingdom lat: 51.45523 lon: -2.59665 facility: Royal Infirmary Edinburgh status: RECRUITING city: Edinburgh zip: EH16 4SA country: United Kingdom lat: 55.95206 lon: -3.19648 facility: Royal Liverpool Hospital status: RECRUITING city: Liverpool zip: L7 8XP country: United Kingdom lat: 53.41058 lon: -2.97794 facility: Royal Free Hospital status: RECRUITING city: London zip: NW3 2QG country: United Kingdom lat: 51.50853 lon: -0.12574 facility: King's College Hospital status: RECRUITING city: London zip: SE5 9RS country: United Kingdom lat: 51.50853 lon: -0.12574 facility: St George's Hospital status: RECRUITING city: London zip: SW17 0QT country: United Kingdom lat: 51.50853 lon: -0.12574 facility: St Mary's Hospital status: RECRUITING city: London zip: W2 1NY country: United Kingdom lat: 51.50853 lon: -0.12574 facility: Nottingham University Hospital status: RECRUITING city: Nottingham zip: NG5 1PB country: United Kingdom lat: 52.9536 lon: -1.15047 facility: Sunderland Royal Hospital status: RECRUITING city: Sunderland zip: SR4 7TP country: United Kingdom lat: 54.90465 lon: -1.38222 hasResults: False