hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06381505 id: STUDY02002103 briefTitle: RetracTOR/ Retractor for Image Guided Trans-Oral Surgery overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2025-12-31 date: 2025-12-31 date: 2024-04-24 date: 2024-04-26 name: Ryan J. Halter class: OTHER name: Dartmouth College briefSummary: This study aims to demonstrate that a polymer retractor functions the same as a standard metal retractor used during endoscopy and throat surgery. The retractor is the device that holds the mouth open so the surgeon can easily access the mouth and throat. For example, this study aims to confirm that the mouth is held open the same amount with a polymer retractor as it is with a metal retractor. Benchtop experiments have demonstrated that the metal and polymer retractor's function the same, and thus this study will use this in patients. conditions: Oral Cavity Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED measure: Comparing intraoperative surgical working volume (SWV) of a radiolucent retractor (custom device) as compared to SWV of standard-of-care metal retractors. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Dartmouth-Hitchcock Medical Center city: Lebanon state: New Hampshire zip: 03756 country: United States name: Joseph Paydarfar, MD role: CONTACT phone: 603-650-8123 email: joseph.a.paydarfar@hitchcock.org lat: 43.64229 lon: -72.25176 hasResults: False
nctId: NCT06381492 id: 2024-0057 id: A536130 type: OTHER domain: UW- Madison id: SMPH/ORTHO&REHAB/PHYS THER type: OTHER domain: UW- Madison id: Protocol Version 11/20/2023 type: OTHER domain: UW- Madison briefTitle: Quantifying Patellar Tendon Microstructure Using DTI overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-12 date: 2024-12 date: 2024-04-24 date: 2024-04-24 name: University of Wisconsin, Madison class: OTHER briefSummary: The goal of this observational study is to understand how diffusion tensor imaging (DTI) relates to other traditional measures and knee function. The main question it aims to answer is:
* complete questionnaires conditions: Patellar Tendinopathy conditions: Anterior Cruciate Ligament Reconstruction studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 40 type: ESTIMATED name: MRI name: Ultrasound (US) measure: Compare scalar parameters of known patellar tendon pathology to the contralateral tendon measure: Compare DTI scalar parameters of known patellar tendon pathology to the healthy regions in the ipsilateral tendon sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Wisconsin - Madison city: Madison state: Wisconsin zip: 53705 country: United States name: Maria Flory role: CONTACT phone: 608-262-8652 email: flory@ortho.wisc.edu lat: 43.07305 lon: -89.40123 hasResults: False
nctId: NCT06381479 id: B031 briefTitle: Exploring the Effects of Probiotics on Workplace Related Stress Symptoms overallStatus: RECRUITING date: 2024-04-19 date: 2024-12-31 date: 2025-03-31 date: 2024-04-24 date: 2024-04-29 name: National Taiwan Sport University class: OTHER name: Bened Biomedical Co., Ltd. briefSummary: There is still a lack of research to explore the interaction between high-pressure workers and probiotics to improve the intestinal microbiota, sleep, inflammation and anti-oxidation. A total of 120 subjects are expected to be recruited and divided into two groups of 60 subjects, receiving probiotics or placebo, and completing a 8-week trial period. conditions: Stress conditions: Sleep Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: probiotics name: placebo measure: Cortisol measure: Perceived Stress Scale (PSS) measure: Job Stress Scale measure: Overwork Survey measure: Insomnia Severity index (ISI) measure: The State Trait Anxiety Inventory (STAI) measure: Depression Anxiety Stress Scales (DASS-42) measure: The Quality of Life, Enjoyment, and Satisfaction Questionnaire-16, QLESQ-16 measure: VAS-GI measure: Patient Global Impression scales of Improvement rated by patient, PGI-C measure: Serotonin measure: GABA measure: Norepinephrine measure: Immunoglobulin A, IgA measure: adrenocorticotropic hormone, ACTH measure: Total Antioxidant Capacity , TAC sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Graduate Institute of Sports Science, National Taiwan Sport University status: RECRUITING city: Taoyuan zip: 33301 country: Taiwan name: Chi-Chang Huang, PI role: CONTACT phone: +88633283201 phoneExt: 2409 email: john5523@ntsu.edu.tw lat: 24.95233 lon: 121.20193 hasResults: False
nctId: NCT06381466 id: D7250C00001 briefTitle: A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral AZD0233 Compared With Placebo in Healthy Adult Participants. overallStatus: RECRUITING date: 2024-04-01 date: 2025-03-20 date: 2025-03-20 date: 2024-04-24 date: 2024-04-24 name: AstraZeneca class: INDUSTRY name: Parexel briefSummary: The purpose of this study is to assess the safety, tolerability, and pharmacokinetics of AZD0233 following single and multiple ascending dose (SAD and MAD) administration in healthy participants. conditions: Dilated Cardiomyopathy studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 96 type: ESTIMATED name: AZD0233 name: AZD0233 Placebo measure: Number of participants with adverse events (AEs) and serious adverse events (SAEs) measure: Maximum observed plasma (peak) drug concentration (Cmax) of AZD0233 measure: Area under the plasma concentration-curve from zero to the last quantifiable concentration (AUClast) of AZD0233 measure: Area under the concentration-time curve in the dose interval (AUCtau) of AZD0233 measure: Area under plasma concentration time-curve from zero to infinity (AUCinf) of AZD0233 measure: Time to reach peak or maximum observed concentration or response following drug administration (tmax) of AZD0233 measure: Terminal elimination half-life (t1/2) of AZD0233 measure: Apparent total body clearance of drug from plasma after extravascular administration (CL/F) of AZD0233 measure: Apparent volume of distribution at steady state following extravascular administration (Vz/F) of AZD0233 measure: Terminal rate constant (λz) of AZD0233 measure: Accumulation ratio for Cmax (Rac Cmax) of AZD0233 measure: Accumulation ratio for AUC (Rac AUC) of AZD0233 measure: Renal clearance (CLR) of AZD0233 measure: Cumulative amount of unchanged drug excreted into urine from time t1 to time t2 [Ae(t1-t2)] of AZD0233 measure: Cumulative amount of unchanged drug excreted into urine (Aeinf) of AZD0233 measure: Percentage of dose excreted unchanged in urine from time t1 to t2 [Fe(t1-t2)] of AZD0233 sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Research Site status: RECRUITING city: Glendale state: California zip: 91206 country: United States lat: 34.14251 lon: -118.25508 hasResults: False
nctId: NCT06381440 id: PROGR-EX_MNESYS briefTitle: Traditional Versus Progressive Robot-assisted Gait Training in People With Multiple Sclerosis and Severe Gait Disability acronym: PROGR-EX overallStatus: RECRUITING date: 2023-11-15 date: 2024-11-30 date: 2024-11-30 date: 2024-04-24 date: 2024-04-24 name: University Hospital of Ferrara class: OTHER name: Universita di Verona name: Università degli Studi di Ferrara briefSummary: Multiple sclerosis (MS) is a demyelinating neurodegenerative disease. Qualitative alterations in walking function in MS people involve 75% of subjects with MS and are determined by reduced coordination, mobility, balance, and increased risk of falling. Robot assisted gait training (RAGT) devices seem effective in MS patients with severe motor disabilities, failing to show significant superiority when compared to intensive overground gait rehabilitation (OGT). This study aims to evaluate the effects of a low-intensity RAGT at progressively increasing intensity compared to conventional RAGT and OGT. conditions: Multiple Sclerosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized Control Trial primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: Lokomat device (Hocoma AG, Volketswil, Switzerland). name: Conventional walking training measure: Walking function measure: Mobility measure: Walking endurance measure: Balance measure: Spasticity measure: Perceived quality of life measure: Perceived walking ability measure: Fatigue measure: Anxiety measure: Depression measure: Kinesiophobia measure: Adaptation to medical condition measure: Coping strategies measure: Muscle oxygen consumption measure: Hemodynamic cortical activation measure: Electrical brain activity measure: miRNA expression measure: Acceptability of robot intervention sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Neuroscience and Rehabilitation, University Hospital of Ferrara status: RECRUITING city: Ferrara state: Emilia Romagna zip: 44124 country: Italy name: Sofia Straudi, MD, PhD role: CONTACT phone: 0532236185 email: s.straudi@ospfe.it name: Sofia Straudi, MD, PhD role: PRINCIPAL_INVESTIGATOR name: Fabio Manfredini, MD, PhD role: PRINCIPAL_INVESTIGATOR name: Nicola Lamberti, PhD role: SUB_INVESTIGATOR name: Andrea Baroni, PhD role: SUB_INVESTIGATOR name: Giulia Fregna, MSc role: SUB_INVESTIGATOR name: Michela Rimondini, PhD role: SUB_INVESTIGATOR name: Marialuisa Gandolfi, MD, PhD role: SUB_INVESTIGATOR name: Luigi Zerbinati, MD role: SUB_INVESTIGATOR lat: 44.83804 lon: 11.62057 hasResults: False
nctId: NCT06381427 id: 01NVF22109 briefTitle: Perioperative Interdisciplinary, Intersectoral Process Optimization in Heart Failure acronym: PeriOP-CARE HF overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2026-08-31 date: 2027-03-01 date: 2024-04-24 date: 2024-04-24 name: University of Giessen class: OTHER name: Deutsche Luft und Raumfahrt briefSummary: Chronic heart failure affects up to three million people in Germany, with prevalence increasing with age. It is a leading cause of cardiovascular disease-related deaths. Patients with heart failure undergoing non-cardiac surgery face higher risks of complications and death compared to those with coronary artery disease. Despite guidelines recommending comprehensive preoperative evaluation, there is no systematic risk assessment structure in place, leading to inadequate perioperative care. This study aims to evaluate a multidisciplinary approach for high-risk patients aged 65 and above, regardless of prior heart failure diagnosis, to mitigate postoperative complications. The investigators measure the NTpro BNP before surgery and include patients with NTproBNP\> 450 in this study and randomize them either to the standard care group or the intervention group.The hypothesis is that standardized risk screening and multidimensional care (Intervention group) can reduce complications in these patients undergoing non-cardiac surgery. conditions: Heart Failure studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 1057 type: ESTIMATED name: Interdisciplinary decision-making for perioperative care measure: combined primary endpoint at 90 days post-operation : re-hospitalization,AKI, bacterial infection and cardiac decompensation measure: Incidence of acute kidney injury measure: Incidence of any, treatable, suspected, or confirmed bacterial infection measure: Incidence of cardiac decompensation measure: Incidence of re-hospitalization measure: Mortality measure: Incidence of myocardial infarction (STEMI, NSTEMI) measure: Incidence of Myocardial Injury after Non-Cardiac Surgery (MINS) measure: Quality of life assessed using PHQ-9 measure: Quality of life assessed using GAD-7 measure: Utilization of services and costs sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Justus Liebig University Giessen, University Hospital Giessen and Marburg city: Gießen zip: 35390 country: Germany name: Michael Sander, PhD role: CONTACT phone: +4964198544401 name: Birgit Aßmus, PHD role: CONTACT lat: 50.58727 lon: 8.67554 hasResults: False
nctId: NCT06381414 id: ChildhoodEarlyOralAging briefTitle: Childhood Early Oral Aging Syndrome: Prevalence, Etiological Factors, and Consequences on Occlusion overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-08-31 date: 2024-12-20 date: 2024-04-24 date: 2024-04-24 name: University of Nove de Julho class: OTHER briefSummary: The Early Oral Aging Syndrome (EOAS) is a broad concept concerning changes in oral health caused by systemic diseases of different origins, which are related to the current lifestyle in the pediatric population. Enamel defects associated with intrinsic and extrinsic factors promote the acceleration of dental structure loss in an early manner, causing impairment of function, aesthetics, and quality of life. In this context, this study aims to identify the prevalence of early childhood tooth wear and its severity using the Early Childhood Oral Aging Syndrome (EOAS) index as a diagnostic and epidemiological survey instrument, considering current alterations found in the pediatric population and verifying possible factors associated with each severity level. Participants aged 3 to 6 years old, enrolled in the pediatric dentistry clinic of the University Nove de Julho, will be selected. Children with imperfect amelogenesis and dentinogenesis, genetic syndromes, and undergoing orthodontic treatment will be excluded from the research. A questionnaire on general health, sleep quality, nutrition, hygiene habits, and parafunctional habits will be administered. Subsequently, a clinical examination will be conducted using the new Early Childhood Oral Aging Syndrome (EOAS) index with scores ranging from 0 to 3 to assess dental wear and dental management, and scores I to III that should be used concomitantly in cases of enamel defects presence, in addition to measuring the Vertical Dimension of Occlusion (VDO). EOAS scores will be computed and statistically analyzed for deciduous dentition with a significance level of P\<0.05. conditions: Aging studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 183 type: ESTIMATED name: Observation measure: Assessment of Tooth Wear and Dental Management measure: Presence of Enamel Defects measure: Vertical Dimension of Occlusion sex: ALL minimumAge: 3 Years maximumAge: 6 Years stdAges: CHILD facility: Nove de Julho University city: São Paulo state: SP zip: 03155-000 country: Brazil lat: -23.5475 lon: -46.63611 hasResults: False
nctId: NCT06381401 id: MS-492-2023 briefTitle: Bupivacaine 0.125% Versus Bupivacaine 0.25% in Superficial Cervical Plexus Block on Operative Field Visibility for Adults Undergoing Tympanomastoid Surgeries overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2024-06-28 date: 2024-07-05 date: 2024-04-24 date: 2024-04-24 name: Cairo University class: OTHER briefSummary: Bleeding is one of the most common complications in tympanomastoid surgery that could prolong the time of operation and also might lead to morbidity. Pain is also one of the most annoying complications of tympanomastoid surgeries. Thus, adequate surgical field visualization is utmost important. A bloodless field allows optimal exposure and identification of vital neurovascular structures. Even small bleeding, inconsequential for the patient's volume status, can create great technical difficulty in the confined space of the tympan, leading to prolonged surgery, incomplete procedures, and increased complications.
To decrease bleeding, different interventions have been proposed, including reverse Trendelenburg position, the application of topical vasoconstrictors, regional anesthesia, laryngeal mask airways, different ventilation strategies, and - most importantly - controlled systemic hypotension, with target mean arterial pressures (MAP) generally between 60 and 70 mmHg. However, induced hypotension can lead to cerebral, renal and mesenteric hypoperfusion, organ damage, and other serious complications.
This prospective randomized controlled double-blinded study will be carried out on 60 patients between 21 to 70 years, with ASA I-II and undergoing tympanomastoid surgery. They were equally divided into two groups: Group A: Patients received SCPB using 0.25% bupivacaine (5ml of bupivacaine 0.5% + 5ml normal saline). Group B: Patients received SCPB using 0.125% bupivacaine (2.5ml of bupivacaine 0.5% + 7.5ml normal saline). conditions: Surgical Field Visualization, Acute Postoperative Pain studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: bupivacaine 0.25% name: bupivacaine 0.125% measure: The total consumption of IV glyceryl trinitrate (GTN) measure: Fentanyl consumption measure: Postoperative pain measure: Postoperative hospital stay sex: ALL minimumAge: 21 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06381388 id: NL86587.041.24 briefTitle: Interaction Between the Brain Hemispheres - Key to Motor Recovery After Stroke acronym: InterAct overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2027-12-31 date: 2028-06-30 date: 2024-04-24 date: 2024-04-24 name: Jord Vink class: OTHER briefSummary: Rationale: Acute stroke leaves many patients with functional deficits, of which upper extremity motor impairment is one of the most disabling. Evidence from imaging and electrophysiological studies converge on the idea that impaired motor function after stroke is associated with disrupted network activity in the brain. Non-invasive brain stimulation methods, like transcranial magnetic stimulation (TMS), can be used to restore disrupted network activity and have been shown to successfully facilitate recovery of motor function in patients with stroke. Application of continuous theta burst stimulation (cTBS), an inhibitory form of TMS, to the contralesional motor cortex has been shown to improve the recovery of motor function in patients with stroke. However, responsiveness to this treatment varies considerably between stroke patients and the mechanisms through which contralesional cTBS facilitates recovery of motor function remain unclear.
Main endpoints: Primary endpoint: Interhemispheric inhibition from the contralesional to ipsilesional primary motor cortex. Secondary endpoints: contralesional intracortical inhibition; effect of contralesional TMS interference on finger tapping frequency. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 40 type: ESTIMATED name: cTBS measure: Interhemispheric inhibition (IHI) measure: Ipsilesional resting motor threshold (RMT) measure: Contralesional resting motor threshold (RMT) measure: TMS interference measure: Intracortical inhibition (ICI) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: De Hoogstraat Revalidatie city: Utrecht country: Netherlands name: Anne Visser-Meily, MD, PhD role: CONTACT lat: 52.09083 lon: 5.12222 hasResults: False
nctId: NCT06381375 id: 24-2-2024 briefTitle: Drug-drug Interactions With Anti-tuberculous Drugs overallStatus: RECRUITING date: 2024-04-30 date: 2024-12-01 date: 2025-02-15 date: 2024-04-24 date: 2024-04-24 name: Cairo University class: OTHER briefSummary: This study aims to assess the prevalence and the outcome of prescribing drugs known to have major drug-drug interactions with anti-tuberculous drugs among Kasr Alainy tuberculous patients. conditions: Drug-drug Interaction studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 400 type: ESTIMATED name: Anti Tuberculosis Drug measure: Estimate the prevalence of prescribing drugs known to have major drug-drug interaction(s) with anti-tuberculous drugs among Kasr Alainy tuberculous patients measure: 2. Assess the outcome of prescribing drugs known to have major drug-drug interaction(s) with anti-tuberculous drugs among Kasr Alainy tuberculous patients (response to treatment and the prevalence of life-threatening events). sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Omnia Azmy Nabeh status: RECRUITING city: Cairo zip: 11562 country: Egypt name: Omnia Azmy Nabeh, MD role: CONTACT phone: 01066969673 email: omnia.azmy@kasralainy.edu.eg lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06381362 id: IGOMIPS briefTitle: Italian Registry of Minimally Invasive Pancreatic Surgery acronym: IGOMIPS overallStatus: RECRUITING date: 2019-02-28 date: 2029-02-28 date: 2029-02-28 date: 2024-04-24 date: 2024-04-24 name: Associazione Italiana per lo Studio del Pancreas class: OTHER briefSummary: Assess the prevalence of minimally invasive pancreatic surgery in the country and its outcomes conditions: Pancreatic Surgery studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2300 type: ESTIMATED name: Minimally invasive pancreatic surgery measure: Postoperative short-term outcomes measure: Long-term oncological outcomes measure: Rate of cases that after a minimally invasive approach had to be converted to and open approach measure: Surgeon learning curve measure: Surgeon learning curve measure: Surgeon learning curve measure: Surgeon learning curve sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Giovanni Capretti status: RECRUITING city: Milan country: Italy name: Giovanni Capretti, Dr. role: CONTACT phone: +390282247646 email: giovanni.capretti@hunimed.eu name: Alessandro Zerbi, Prof. role: PRINCIPAL_INVESTIGATOR name: Giovanni Capretti, Dr. role: SUB_INVESTIGATOR lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06381349 id: GPOEM-GEMS briefTitle: Predicting Outcomes of GPOEM Using Gastric Electrical Mapping acronym: GPOEM-GEMS overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05-01 date: 2026-06-01 date: 2024-04-24 date: 2024-04-24 name: Chris Varghese class: OTHER briefSummary: Gastric peroral endoscopic myotomy (GPOEM) is a minimally-invasive procedure that involves dividing the pylorus, to enhance gastric emptying in gastroparesis patients. This is a single-arm, multi-centre, prospective observational study to determine the clinical utility of Gastric Alimetry in predicting GPOEM treatment outcomes. The investigators further aim to develop a clinical decision rule to inform patient selection. Gastric Alimetry will be conducted \<1 month prior to GPOEM. All subjects will then be followed up for 12 months. conditions: Gastroparesis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 300 type: ESTIMATED name: Gastric Alimetry test measure: Gastroparesis Cardinal Symptom Index (GCSI) measure: Patient Assessment of Upper GastroIntestinal Disorders-Quality of Life (PAGI-QoL) measure: EQ-5D scores measure: Patient assessment of upper gastrointestinal disorders-symptom severity index (PAGI-SYM) measure: Patient Health Questionnaire - 8 (PHQ-8) measure: Generalized Anxiety Disorder 7-item (GAD-7) measure: Perceived Stress Scale 4 (PSS-4) measure: Brief Illness Perception Questionnaire-Revised measure: Alimetry® Gut-Brain Wellbeing (AGBW) measure: Work Productivity and Activity Impairment (WPAI) measure: Change in Gastric Alimetry Phenotype sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False