hackint0sh/New-Dataset huggingface dataset:
receive follow-up before surgery (baseline) and 3 days, 4 weeks, 12weeks after surgery. conditions: Emphysema conditions: Chronic Obstructive Pulmonary Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: bronchoscopic lung volume reduction surgery using endobronchial valve measure: Percentage change in FEV1 relative to baseline measure: Percentage of subjects with FEV1 improvement ≥ 12% after bronchodilators measure: Percentage change in RV relative to baseline measure: Percentage change in TLC relative to baseline measure: Percentage change in DLCO relative to baseline measure: Percentage change in SGRQ score relative to baseline measure: Percentage change in mMRC grade relative to baseline measure: Percentage change in 6MWD relative to baseline measure: the incidence of surgical-related adverse events sex: ALL minimumAge: 40 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: China-Japan Friendship Hospital city: BeiJing state: Beijing zip: 100029 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06349161 id: 1451_02/BVNTW-VNCSKTE briefTitle: Long-term Outcome of Retroperitoneoscopic One-trocar-assisted Pyeloplasty: A Single-center and Single-surgeon Experience overallStatus: COMPLETED date: 2011-05 date: 2013-06 date: 2024-03 date: 2024-04-05 date: 2024-04-05 name: National Children's Hospital, Vietnam class: OTHER briefSummary: Open surgical dismembered pyeloplasty has traditionally been the preferred method for treating ureteropelvic junction obstruction (UPJO), with a success rate exceeding 94%. However, it is associated with drawbacks such as increased postoperative pain, extended hospital stays, and visible scarring. Minimally invasive alternatives, including laparoscopic pyeloplasty (LP) and robot-assisted laparoscopic pyeloplasty (RALP), have gained popularity since their introduction in 1993, offering comparable success rates to open surgery while providing cosmetic benefits and shorter hospital stays. Nevertheless, these techniques present challenges in pediatric patients, including limited working space, technical complexities, and prolonged operative times. The retroperitoneoscopic one-trocar-assisted pyeloplasty (OTAP) method, introduced in 2007, combines the advantages of minimally invasive surgery with the success rates of standard dismembered pyeloplasty. Despite favorable outcomes reported by several researchers, comprehensive studies regarding long-term follow-up and clinical outcomes are lacking. This study aims to evaluate the long-term outcomes of OTAP, addressing this gap in the medical literature. conditions: Ureteropelvic Junction Obstruction studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 70 type: ACTUAL name: One-trocar-assisted pyeloplasty measure: Operative time measure: Conversion to open measure: Extension of skin incision measure: Postoperative complications measure: Median length of hospital stays measure: Median follow up length measure: Post-operative mean APD measure: Post-operative mean DRF measure: Mean incision length measure: Recurrence sex: ALL minimumAge: 6 Months maximumAge: 5 Years stdAges: CHILD facility: The National Hospital of Pediatrics city: Hanoi country: Vietnam lat: 21.0245 lon: 105.84117 hasResults: False
nctId: NCT06349148 id: NESTLE2022QN-0007 briefTitle: The Effects of Immunonutrition Therapy on Locally Advanced Cervical Cancer Patients overallStatus: RECRUITING date: 2024-01-01 date: 2025-08 date: 2025-12 date: 2024-04-05 date: 2024-04-05 name: SHUANGZHENGJIA class: OTHER briefSummary: The goal of this open-label randomized control trial is to study the effect of immunonutrition in locally advanced cervical cancer (LACC) with standard concurrent chemoradiotherapy. LACC patients undergoing radical synchronous chemoradiotherapy will be randomized into the experimental group receiving enteral immunonutrition therapy and the control group receiving standard enteral nutrition support.The main purpose it aims to answer are:1）Can immunonutrition therapy improve patients' dose-limiting toxicity(DLT) and DLT-free survival? 2）Can immunonutrition therapy improve patients' nutritional status and quality of life? conditions: Cervical Cancers studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 50 type: ESTIMATED name: enteral immunonutrition name: standard oral enteral nutrition measure: Dose-limiting toxicity measure: DLT-free survival measure: compliance measure: Prevalence of malnutrition measure: Prevalence of sarcopenia measure: QoL (Quality of life) measure: Objective response rate (ORR) measure: laboratory tests measure: 2-year overall survival measure: 2-year progression-free survival sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cancer Hospital, Chinese Academy of Medical Sciences status: RECRUITING city: Beijing zip: 100021 country: China name: SHUANGZHENG JIA, PhD role: CONTACT lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06349135 id: A.Ayman OMFS briefTitle: Assessment of Serum Concentration of Interleukin-17 and Osteoprotegerin in Response to Surgical Trauma Induced by Management of Mandibular Fractures Via Intraoral Versus Extraoral Approaches: Prospective Cohort Study overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-04-15 date: 2025-12-15 date: 2024-04-05 date: 2024-04-05 name: Aya Ayman Ahmed class: OTHER briefSummary: Assessment of Serum Concentration of Interleukin-17 and Osteoprotegerin in Response to Surgical Trauma Induced by Management of Mandibular Fractures via Intraoral Versus Extraoral Approaches: Prospective Cohort Study conditions: Mandibular Fractures studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2 type: ESTIMATED name: Open Reduction & Internal Fixation measure: IL-17 measure: OPG measure: Blood Loss measure: Operative time sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT hasResults: False
nctId: NCT06349122 id: 2023-509421-41-00 briefTitle: Screen-and-treat Strategy for Vaginal Flora Abnormalities in Pregnant Women at High Risk of Preterm Birth acronym: AUTOP2 overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2027-03 date: 2028-01 date: 2024-04-05 date: 2024-04-05 name: Assistance Publique Hopitaux De Marseille class: OTHER briefSummary: Preterm birth is an important cause of death and disabilities. Bacterial vaginosis (BV) is a common vaginal dysbiosis or abnormal microbiota, with a predominance of anaerobic bacteria with a lack of Lactobacillus, with various diagnosis methods. Often asymptomatic, BV increases the risk of preterm birth according to the gestational age at diagnosis. BV is usually diagnosed by conventional diagnosis such as Nugent score. Molecular diagnosis of BV has been demonstrated to be more reproducible, more accurate and to better define dysbiosis.
The hypothesis is that a strategy for screening and treating vaginal flora abnormalities and their recurrences using molecular biology in women with a history of prematurity or late-term abortion could be effective in reducing premature births by 40%. conditions: Bacterial Vaginosis conditions: Vaginal Dysbiosis conditions: Premature Delivery studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 1292 type: ESTIMATED name: Vaginal flora abnormalities screening and quantification using molecular biology technique name: Azithromycine name: Ceftriaxone name: Metronidazole name: Clotrimazole, Vaginal name: Usual Care measure: The rate of preterm birth sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06349109 id: PA-WPW briefTitle: Physical Activity in Children With Wolff-Parkinson-White Syndrome overallStatus: RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-05-01 date: 2024-04-05 date: 2024-04-09 name: Karamanoğlu Mehmetbey University class: OTHER briefSummary: The aim of this study was to investigate the level of physical activity and its determinants in children with WPW. conditions: Wolff-Parkinson-White Syndrome studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 30 type: ESTIMATED name: Cardiopulmonary exercise test name: Atrial-Ventricular Strain Analysis name: Arterial Stiffness Measurement name: Physical Activity Level name: Physical Activity Barriers Assesment measure: The Physical Activity Questionnaire for Older Children Score measure: VO2peak measure: aPWV measure: GLS measure: LASr measure: LASct measure: LAScd measure: Physical activity barriers (Parent) scale score measure: Physical Activity Outcome Expectancies (Child) scale score measure: Physical Activity Home Environment (Child) scale score sex: ALL minimumAge: 7 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Hacettepe University status: RECRUITING city: Ankara country: Turkey name: Haluk Tekerlek, PhD role: CONTACT phone: +905355915009 email: haluktekerlek@gmail.com lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06349096 id: ALM-HAR-CLL-23-01 briefTitle: Safety And Efficacy Investigation Of The Effects Of ClearLift Q-Switched Nd:Yag 1064nm Laser Module In The Treatment Of Facial Skin Wrinkles overallStatus: NOT_YET_RECRUITING date: 2024-03-26 date: 2024-10 date: 2024-10 date: 2024-04-05 date: 2024-04-05 name: Alma Lasers class: INDUSTRY briefSummary: Alma Lasers ClearLift is a fractional non-ablative Q-Switched laser, allowing practitioners to use the benefits of a high intensity QS laser for the treatment of aged skin. Alma Harmony ClearLift uses a fractional QS laser to achieve a deep mechanical effect beneath the epidermis via a photoacustic effect. This creates a controlled dermal wound while leaving the epidermis intact. The wound healing process stimulates growth of new collagen, skin contracture and tightening. This procedure is virtually painless with no downtime and is safe for all skin types.
Based on this background, we have considered an interest to design a study aimed at assessing the efficacy and safety of a treatment course with ClearLift Module in patients with facial skin wrinkles conditions: Facial Skin Wrinkles studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 36 type: ESTIMATED name: Alma Harmony measure: Primary endpoint measure: Secondary endpoint measure: Secondary endpoint measure: Secondary endpoint measure: Safety & Tolerability measure: Safety & Tolerability sex: FEMALE minimumAge: 35 Years maximumAge: 55 Years stdAges: ADULT facility: San Luca Medical Clinic city: Tirana country: Albania name: Arminda Avdulaj, MD role: CONTACT phone: 694488000 phoneExt: +355 email: avdulajarminda@gmail.com name: Arminda Avdulaj, MD role: PRINCIPAL_INVESTIGATOR lat: 41.3275 lon: 19.81889 hasResults: False
nctId: NCT06349057 id: AnkaraCHBilkent.1 briefTitle: The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery overallStatus: RECRUITING date: 2024-01-01 date: 2024-12-01 date: 2024-12-30 date: 2024-04-05 date: 2024-04-05 name: Ankara City Hospital Bilkent class: OTHER briefSummary: Many drugs have anticholinergic activity. This means that it blocks the muscarinic binding of the neurotransmitter acetylcholine.
In this study, the anticholinergic burden of the patients in the perioperative period will be calculated with the Anticholinergic Cognitive Burden Scale (ACBS) and patients with a score of 1 or above will be included in the study. Anticholinergic load of drugs used in the intraoperative period; Its effect on postoperative hospital stay, morbidity and mortality following elective heart surgery will be investigated. conditions: Mortality conditions: Postoperative Complications studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: reducing anticholinergic burden measure: Mortality measure: Effects on postoperative recovery measure: Effects on postoperative recovery measure: Postoperative complication measure: Length of stay in hospital and intensive care unit sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Seda Kurtbeyoğlu status: RECRUITING city: Çankaya state: Ankara zip: 06800 country: Turkey name: Seda Kurtbeyoğlu role: CONTACT phone: +905388342776 email: kurtbeyogluseda@gmail.com lat: 39.9179 lon: 32.86268 hasResults: False
nctId: NCT06349044 id: BASIMA briefTitle: A Randomized, Multicenter Phase II Basket Study of Hypofractionated Radiotherapy/Stereotactic Body Radiotherapy Followed by Immunotherapy-Based Systemic Therapy +/- L. Rhamnosus M9 for the First-Line Treatment of Advanced Digestive System Malignancies. overallStatus: RECRUITING date: 2024-03-20 date: 2025-12-31 date: 2025-12-31 date: 2024-04-05 date: 2024-04-05 name: Zhejiang Cancer Hospital class: OTHER briefSummary: Based on the interaction between radiation therapy and immunotherapy and the potential potentiation of Probio-M9 for the treatment of ICIs, this study is planned to design an integrated treatment protocol for the first-line treatment of advanced gastrointestinal tumors through the use of macrofractionated radiotherapy as a means of immune activation, combined with the synergistic effect of Probio-M9 microbial agents and PD-1 inhibitors. conditions: Gastroesophageal Junction Adenocarcinoma conditions: Liver Cancer Stage IV conditions: Biliary Tract Cancer conditions: Pancreatic Adenocarcinoma conditions: Colorectal Cancer conditions: Gastric Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 150 type: ESTIMATED name: Hypofractionated radiotherapy/SBRT（5-8 Gy/fx，3-5 fx） name: Anti-PD-1 monoclonal antibody name: Oxaliplatin and Capecitabine name: Anti-VEGF 15mg/kg name: Anti-VEGF 7.5mg/kg name: Gemcitabine and Cisplatin name: Gemcitabine and Albumin paclitaxel measure: ORR measure: ORR measure: adverse effects rate measure: Qol measure: PFS measure: OS measure: Qol sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Zhengjiang Cancer Hospital status: RECRUITING city: Hangzhou state: Zhejiang country: China name: Ji Zhu role: CONTACT phone: 13501978674 email: zhuji@zjcc.org.cn lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06349031 id: IEC/IMS.SH/SOA/2024/683 briefTitle: Comparison of Efficacy & Tolerability Of PEG 4000 Versus PEG 3350+ Electrolytes for Pediatric Fecal Disimpaction overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-09-15 date: 2024-09-15 date: 2024-04-05 date: 2024-04-12 name: Institute of Medical Sciences and SUM Hospital class: OTHER briefSummary: Childhood constipation is a common but serious gastrointestinal disorder prevalent worldwide. In 90-95% of children, it is of functional origin. Thirty to seventy-five percent of children with functional constipation also have fecal impaction. The treatment strategy for functional constipation includes fecal disimpaction and maintenance therapy to ensure regular bowel movements.
Polyethylene glycol (PEG) based laxatives have been recommended as the first-line therapeutic agents. The commonly used formulations are PEG 3350 with a molecular weight between 3200- 3700 g/mol and PEG 4000 with molecular weight of 4000 g/mol. Both are shown to be effective in pediatric constipation management in placebo-controlled trials. PEG 3350 + Electrolyte (E) is more widely used than PEG 4000 for the management of constipation. This might be because of the perception that PEG 3350 + E is safer in terms of preventing electrolyte imbalance. However, because of the inclusion of electrolytes, PEG 3350+ E solution taste saltier than PEG 4000. Many patients struggle to tolerate the unpleasant taste resulting in the high incidence of non-compliance. To date, no pediatric trials have compared PEG 4000 versus PEG 3350+E for management of Fecal disimpaction.
Present study has been planned to evaluate the efficacy \& tolerability of PEG 4000 versus PEG 3350+ E for fecal disimpaction in pediatric functional constipation. Patients between age 1-16 years having functional constipation (as per ROME IV criteria) with fecal impaction will be included. Subjects will be randomly assigned to either PEG 4000 or PEG 3350+E at a ratio of 1:1. They will be stratified into 3 different age groups: 1-5 years, 6-11 years, and 12-16 years. They will receive either of the PEG solutions (as per allocation) at a dose of 1.5 gm/kg/day for 6 consecutive days or till the resolution of fecal impaction whichever is earlier. The resolution of fecal impaction is defined as the passage of clear liquid stool and the disappearance of palpable abdominal fecolith.
4. Proportion of subjects discontinuing the treatment due to palatability issues in each arm conditions: Functional Constipation conditions: Fecal Impaction conditions: Constipation - Functional conditions: Constipation Chronic Idiopathic conditions: Pediatric Functional Constipation studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: DOUBLE BLIND RANDOMIZED CONTROLLED TRIAL primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: One member of the research group will do the treatment allocation and will not be involved in clinical evaluation and collection of outcome data. Both study medications will be provided by him/her in opaque bottles with identical packaging and labeling. Neither the participants nor the rest of the study personnel will be aware of the treatment allocation. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Administration of Polyethylene Glycol (PEG) 4000 as per treatment allocation to participants name: Administration of Polyethylene Glycol (PEG) 3350 + Electrolyte as per treatment allocation to participants measure: Proportion of subjects achieving fecal disimpaction in Each Arm measure: Total no of Days required to achieve fecal disimpaction in each arm measure: Cumulative PEG dose required for fecal disimpaction in each arm measure: Proportion of subjects reporting palatability issues in each arm measure: Proportion of subjects discontinuing the treatment due to palatability issues in each arm sex: ALL minimumAge: 1 Year maximumAge: 16 Years stdAges: CHILD facility: Institute of Medical Sciences (IMS) and SUM Hospital city: Bhubaneswar state: Odisha zip: 751003 country: India name: Kalpana Panda, MD, DM role: CONTACT phone: 91-9717133189 email: drkalpanapanda@gmail.com name: J Bikrant kumar Prusty, MD role: CONTACT phone: 91-9090205041 email: princejammy142@gmail.com name: Mrutunjay Dash, MD role: SUB_INVESTIGATOR name: Basudev Biswal, MD role: SUB_INVESTIGATOR name: Mamta Devi Mohanty, MD role: SUB_INVESTIGATOR name: Prasant Saboth, MD role: SUB_INVESTIGATOR lat: 20.27241 lon: 85.83385 hasResults: False
nctId: NCT06349018 id: IRB-2023-972 briefTitle: Effects of Isotonic Beetroot Supplementation on Sprint Interval Exercise Performance overallStatus: RECRUITING date: 2024-02-20 date: 2025-02-28 date: 2025-02-28 date: 2024-04-05 date: 2024-04-09 name: Nanyang Technological University class: OTHER briefSummary: This study aims to examine the effects of dietary nitrate supplementation via beetroot juice on sprint interval cycling exercise performance. Twenty-four participants (male or female) will undertake a randomized, crossover trial where they consume either (i) an isotonic beetroot juice drink containing nitrate (12.9 mmol) for 5 days or (ii) an isotonic sports drink (no nitrate) for 5 days. On Day 5 of each trial, participants will come to the laboratory and 2 hours after consuming their allocated drink will complete a 6 bouts of sprint interval exercise. Power output during cycling will be measured as the primary outcome measure. Salivary and plasma measures of nitrate and nitrite will be taken over the course of the morning on Day 5. After a 5-day washout period participants will crossover and begin their second trial. conditions: Exercise Performance studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: DOUBLE maskingDescription: Both isotonic drinks (high nitrate or no nitrate) are deidentified and labelled (coded) by a third party not involved with the research. Randomization and allocation are completed by a third party not involved in the testing. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 24 type: ESTIMATED name: Dietary Supplement: High nitrate isotonic drink name: Dietary Supplement: No nitrate isotonic drink measure: Power output during maximal sprint cycling measure: Salivary nitrate measure: Plasma nitrate and nitrite measure: Muscle oxygenation measure: Sensory evaluation (Acceptance and Preference Test Evaluation by Meilgaard et al 2007) measure: Stroop test sex: ALL minimumAge: 21 Years maximumAge: 40 Years stdAges: ADULT facility: Human Bioenergetics Laboratory, National Institute of Education, Nanyang Technological University status: RECRUITING city: Singapore zip: 637616 country: Singapore name: Stephen Burns, PhD role: CONTACT phone: 65 67903354 email: stephen.burns@nie.edu.sg lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06349005 id: 111 briefTitle: Laryngoscopy and Coronary Artery Bypass Graft Surgery acronym: VL overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-08-01 date: 2024-09-01 date: 2024-04-05 date: 2024-04-05 name: Konya Meram State Hospital class: OTHER briefSummary: In this prospective, randomized, controlled trial, the purpose is to compare Macintosh laryngoscope, EzVision® video laryngoscope, McGrath® video laryngoscope and Storz® video laryngoscope in terms of hemodynamic response associated with intubation in adult patients undergoing Coronary Artery Bypass Surgery (CABG). conditions: Videolaryngoscopy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 112 type: ESTIMATED name: Tracheal intubation using Storz VL name: Tracheal intubation using Macintosh laryngoscopy name: Tracheal intubation using MacGrath VL name: Tracheal intubation using EzVision VL measure: Hemodynamic response measure: Hemodynamic response measure: Intubation time measure: Visualization of the glottis sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Betul Kozanhan city: Konya zip: 42005 country: Turkey lat: 37.87135 lon: 32.48464 hasResults: False
nctId: NCT06348992 id: HMUDQ20240318001 briefTitle: ACT Combined Yoga for Parental Burnout in Parents With Autistic Children overallStatus: RECRUITING date: 2023-09-01 date: 2024-12-31 date: 2024-12-31 date: 2024-04-05 date: 2024-04-05 name: Harbin Medical University class: OTHER briefSummary: OBJECTIVE: To explore the intervention effect of ACT combined with a yoga intervention program on parenting burnout in parents with ASD.