hackint0sh/New-Dataset huggingface dataset:
Participants will assess to an inclusion visit (disease evaluation purpose) and then four IPL treatment visit to finish with the last visit (disease evaluation purpose). conditions: Dry Eye Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: MULTI-CENTER, PROSPECTIVE, RANDOMIZED, SHAM-CONTROLLED, SUPERIORITY, NON-SIGNIFICANT RISK primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Intense pulsed light with C.STIM device measure: Tear Break-Up Time evolution measure: dry eye signs and symptoms measure: dry eye signs and symptoms measure: dry eye signs and symptoms measure: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability] measure: Meibum quality measure: Meibum Expressibility measure: Use of artificial tear drops measure: Use of artificial tear drops measure: Glaucoma sex: ALL minimumAge: 22 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Visionary Consultants Inc. status: RECRUITING city: Lexington state: Kentucky zip: 40517 country: United States name: Dr. KARPECKI role: CONTACT phone: 463-210-6618 email: karpecki@karpecki.com lat: 37.98869 lon: -84.47772 facility: Triangle Eye Consultants status: ACTIVE_NOT_RECRUITING city: Raleigh state: North Carolina zip: 27617 country: United States lat: 35.7721 lon: -78.63861 facility: Toyos Clinic status: RECRUITING city: Nashville state: Tennessee zip: 37215 country: United States name: Dr. TOYOS role: CONTACT phone: 615-327-4015 email: rostar80@gmail.com lat: 36.16589 lon: -86.78444 facility: Eye Centers of Racine & Kenosha status: RECRUITING city: Kenosha state: Wisconsin zip: 53142 country: United States name: Dr SINGH role: CONTACT phone: 312-371-4335 email: ipsingh@amazingeye.com lat: 42.58474 lon: -87.82119 hasResults: False
nctId: NCT06349343 id: UHCT230949 briefTitle: CD19/BCMA HLA-independent TCR-T Cell Therapy for Refractory/Moderate-to-severe Systemic Lupus Erythematosus overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-01 date: 2026-01 date: 2024-04-05 date: 2024-04-05 name: Wuhan Union Hospital, China class: OTHER briefSummary: The purpose of the study is to explore the safety and efficacy of cluster of differentiation 19 (CD19)/B cell maturation antigen (BCMA) human leukocyte antigen (HLA)-independent T cell receptor (TCR) -T therapy in refractory/moderate-to-severe systemic lupus erythematosus(SLE). conditions: Systemic Lupus Erythematosus studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: CD19/BCMA Hi-TCR-T cell therapy measure: Safety and tolerability measure: Proportion of subjects with SRI-4 response measure: Changes in the Safety of Estrogens in Lupus Erythematosus National Assessment - Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) score from baseline measure: Changes in the BILAG-2004 score from baseline measure: Changes in the Physician Global Assessment (PGA) score from baseline measure: Pharmacokinetics (PK) measure: Pharmacodynamics (PD) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06349330 id: 2022/00908 briefTitle: The Immediate Effectiveness of a 3D Intraoral Scanner as an Oral Hygiene Educational Tool acronym: 3D scanner overallStatus: RECRUITING date: 2023-11-07 date: 2024-07-31 date: 2024-07-31 date: 2024-04-05 date: 2024-04-24 name: National University Hospital, Singapore class: OTHER briefSummary: The goal of this randomized controlled clinical trial is to compare the immediate effectiveness of 3D intra-oral scanners and standard oral hygiene instructions in improving the oral hygiene of 52 subjects. The main question\[s\] it aims to answer are:
To investigate the immediate effectiveness on the use of 3D intraoral scanner in the improvement of oral hygiene in two (2) parallel arm study with 52 subjects (n=52). The study will take place over 1 visit. primaryPurpose: PREVENTION masking: SINGLE whoMasked: INVESTIGATOR count: 52 type: ESTIMATED name: Test: 3D intra-oral scanner name: Control: Standard oral hygiene measure: Full mouth plaque score (%) measure: Patient's satisfaction of 3D scanner and standard oral hygiene group based on 5-point Likert Scale sex: ALL minimumAge: 21 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National University Hospital, Singapore status: RECRUITING city: Singapore country: Singapore name: Xiao Tong, Jacinta Lu, BDS role: CONTACT phone: 6716 2233 email: jacinta_lu@nuhs.edu.sg name: Xiao Tong, Jacinta Lu, MDS role: PRINCIPAL_INVESTIGATOR lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06349317 id: 2024-005 briefTitle: Neoadjuvant IMRT Combined With Camrelizumab and Apatinib for Resectable HCC With PVTT overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-05 date: 2026-06 date: 2024-04-05 date: 2024-04-05 name: Yongyi Zeng class: OTHER briefSummary: This study is an open-label, single-arm prospective clinical trial that evaluates the efficacy and safety of neoadjuvant intensity-modulated radiotherapy combined with perioperative camrelizumab and apatinib in the treatment of resectable hepatocellular carcinoma with portal vein tumor thrombus. conditions: Hepatocellular Carcinoma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 33 type: ESTIMATED name: Neoadjuvant intensity-modulated radiotherapy combined with perioperative camrelizumab and apatinib measure: 1-year Event-Free Survival (EFS) rate measure: Event-Free Survival (EFS) measure: Overall Survival (OS) measure: Disease-Free Survival (DFS) measure: R0 resection rate measure: Overall Objective Response of primary liver tumor and PVTT measure: Surgical safety measure: Safety of radiotherapy, camrelizumab and apatinib treatment measure: Exploratory Endpoints sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06349304 id: S25 briefTitle: Impact of Grape Powder Consumption on Eye Health and Glycemic Status in Singapore Older Adults overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-08-01 date: 2025-08-01 date: 2024-04-05 date: 2024-04-05 name: National University of Singapore class: OTHER name: California Table Grape Commission briefSummary: The purpose of this study is to understand the impacts of regular consumption of freeze-dried table grape powder on eye health and regulation of advanced glycation end products in Singapore older adults. The investigators hypothesize that regular consumption of freeze-dried table grape powder will promote improvements in eye health and lower levels of advanced glycation end products when compared to the placebo group. conditions: Macula; Degeneration conditions: Aging conditions: Advanced Glycation End Products studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 46 type: ESTIMATED name: Freeze-dried table grape powder name: Placebo grape powder measure: Macular pigment optical density measure: Visual acuity measure: Photostress recovery time measure: Visual function questionnaire 25 measure: Skin advanced glycation end products levels measure: Dietary advanced glycation end products level measure: Blood advanced glycation end products levels measure: Contrast sensitivity measure: Concentration of tumour necrosis factor-α measure: Concentration of interleukin-6 measure: Concentration of high-sensitivity C-reactive protein measure: Concentration of fasting blood glucose measure: Concentration of malondialdehyde measure: Concentration of 8-isoprostaglandin-F2α measure: Skin carotenoid status measure: Concentration of insulin measure: Percentage of glycated hemoglobin measure: Measurement of height measure: Measurement of blood pressure measure: Measurement of weight measure: Measurement of waist circumference sex: ALL minimumAge: 60 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06349291 id: 0074-24-MMC briefTitle: Venous Thrombosis After Removal of Central Venous Catheter overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2025-08-01 date: 2025-08-01 date: 2024-04-05 date: 2024-04-05 name: Meir Medical Center class: OTHER briefSummary: Insertion of intravenous catheter is a very common operation in patients in the general intensive care unit. These catheters are used for a variety of purposes - administration of inotropics/pressors, intravenous nutrition, concentrated electrolytes and performing dialysis.There are several known complications of central venous catheter insertion, such as thrombosis and pulmonary embolism. In a literature review, there are no clear data regarding the rate of intravenous thrombosis in patients after removal of a central venous catheter. These findings are often discovered randomly, when the patient undergoes imaging for a different indication. There is no recommendation for an active search for intravenous thrombi at the catheter insertion sites in these patients, and it is not entirely clear whether it is mandatory to administer anticoagulant treatment in these patients if thrombi are randomly discovered at the catheter insertion sites.
In this study, we aim to check the proportion of patients who developed thrombosis at the central catheter insertion sites after its removal, to check whether there are catheter insertion sites that are at a higher risk of developing thrombosis than other sites, and to check whether there are predictive characteristics for the development of this type of thrombosis. conditions: Thrombosis, Venous studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Detection of venous thrombosis via US measure: Rate of DVT after removal of central venous catheter sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Meir Medical Center city: Kfar Saba country: Israel lat: 32.175 lon: 34.90694 hasResults: False
nctId: NCT06349265 id: 02 briefTitle: Ultrasound-Guided 5% Dextrose Injection for Carpal Tunnel Syndrome overallStatus: COMPLETED date: 2023-10-02 date: 2024-02-02 date: 2024-03-02 date: 2024-04-05 date: 2024-04-05 name: Kastamonu University class: OTHER briefSummary: This study was a prospective randomized double-blind clinical trial conducted at the Physical Medicine and Rehabilitation Clinic of a local research and training hospital in Turkey from October 2023 and May 2024. Patients diagnosed with CTS were classified into three groups: severe, mild, and moderate CTS, based on the results of electrophysiological tests. An ultrasound-guided 5% Dextrose in Water injection was performed. The primary outcome measurement was the Visual Analog Scale (VAS), while secondary measurements were the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) and the Dolour Neuropathic en 4 Questions (DN4) questionnaire. The measurements were performed before the injection and at the first week, first month and third month follow-up times. The distribution of data within groups was examined using the Shapiro-Wilk test and Q-Q plots. The study also analyzed temporal changes, group differences, and intergroup changes using repeated measures ANOVA models. conditions: Carpal Tunnel Syndrome studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 33 type: ACTUAL name: Carpal Tunnel Hydrodissection with %5 dextrose in water injection measure: Visual Analogue Scale(VAS) measure: Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) measure: Dolour Neuropathique en 4 Questions (DN4) questionnaire sex: ALL minimumAge: 20 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Gamze Gül Güleç city: Kastamonu zip: 37150 country: Turkey lat: 41.37805 lon: 33.77528 hasResults: False
nctId: NCT06349252 id: LUNGTNM briefTitle: Survival Validation and Gene Mutations of N Descriptors in the Ninth Edition of the TNM Classification for Lung Cancer overallStatus: RECRUITING date: 2021-01-01 date: 2024-08-01 date: 2025-01-01 date: 2024-04-05 date: 2024-04-05 name: Fudan University class: OTHER briefSummary: The International Association for the Study of Lung Cancer Staging Committee recently unveiled the ninth edition of TNM staging system for lung cancer. This study aims to explore survival outcomes, stage grouping, and gene mutations in N descriptors of this new classification system. conditions: Non-small Cell Lung Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 1263 type: ESTIMATED name: Radical resection measure: Overall Survival sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Fudan University Cancer Center status: RECRUITING city: Shanghai state: Shanghai zip: 200032 country: China name: Chen Haiquan, MD role: CONTACT phone: +86-21 64175590 phoneExt: 1707 email: hqchen1@yahoo.com lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06349239 id: 24Hemato01 briefTitle: Oral Azacitidine Maintenance Post-CPX 351 acronym: ORAZ-351 overallStatus: RECRUITING date: 2020-01-01 date: 2025-01-01 date: 2025-01-01 date: 2024-04-05 date: 2024-04-05 name: Centre Hospitalier Universitaire de Nice class: OTHER briefSummary: Approximately 10% of patient develop AML after chemotherapy or radiation for unrelated disease (t-AML) and 20% have AML with an antecedent hematologic disorder (AML-MRC). CPX-351 (Vyxeos), a liposomal formulation of a fixed molar ratio (1:5) daunorubicin and cytarabine, has been approved for treatment of adults with newly diagnosed t-AML or AML-MRC. CPX-351 significantly improved median overall survival.
Although induction chemotherapy results in remission in many older patients with AML, relapse is common and overall survival is poor. For patients not eligible for HSCT, maintenance therapies are needed to reduce the risk of relapse and prolong overall survival without causing undue adverse effects or compromising health-related quality of life. Oral azacitidine (ONUREG) has been approved by FDA on September, 2020, to treat adult patients with AML who achieved CR or CRi following intensive induction chemotherapy with or without consolidation and who are not able to complete intensive curative therapy (not candidate to HSCT).
But there are few data on its efficacy as a post-CPX-351 maintenance agent in patients with newly diagnosed t-AML or AML-MRC or de novo AML.THe aim of this study is to show the improvement of overall survival with use of oral Azacitidine as maintenance for patients with de novo AML including t-AML or AML-MRC who achieved complete remission or complete remission with incomplete blood count recovery after CPX-351. Long-term product safety is also being studied conditions: Acute Myeloid Leukemia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 100 type: ESTIMATED name: No intervention measure: overall survival measure: Safety and tolerance sex: ALL minimumAge: 64 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU de Nice status: RECRUITING city: Nice country: France name: CLUZEAU thomas role: CONTACT lat: 43.70313 lon: 7.26608 hasResults: False
nctId: NCT06349213 id: C23-19 id: 2023-A02263-42 type: OTHER domain: Secondary ID briefTitle: Uncovering the Cognitive and Neural Mechanisms Underlying Cognitive Time acronym: TIMES overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2026-11-01 date: 2030-11-01 date: 2024-04-05 date: 2024-04-10 name: Institut National de la Santé Et de la Recherche Médicale, France class: OTHER_GOV briefSummary: Time processing, the ability to process and encode temporal information, is essential for cognitive functioning and for a large number of daily life activities. In particular, the processing of durations of several seconds is central to cognition, impaired in several pathologies, and has been associated with cognitive changes with advancing age. While behavioral studies have been conducted to specify the neural bases of temporal cognition and their association with other cognitive functions, the mechanisms underlying age-related changes, and individual differences, remain unknown. The project will characterize ageing effects on timing mechanisms and their neural underpinnings. Building on recent advances from neuroscience and age-related cognitive changes, the project focuses on the precision of duration processing, that declines with age, and the associated neural bases. Participants will perform a duration judgement task while (a) electroencephalography, and (b) functional magnetic resonance imaging activity are simultaneously recorded to investigate age effects on structural and functional network connectivity. In addition, striatal dopamine will be measured using a FDOPA PETscan. Evaluation of other temporal cognition processes and general cognition will also be performed. This combination offers a unique opportunity to accurately specifying the neurophysiological underpinning of aging effects on time processing changes. This project will further our understanding of the variability of cognitive performance with advancing age, and contribute to identifying new measures of temporal impairments. conditions: Healthy Aging studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 130 type: ESTIMATED name: FDOPA injection before PET imaging name: Time perception tasks name: fMRI imaging name: EEG imaging name: 3 year follow-up measure: EEG phase lag index differences between group sex: ALL minimumAge: 20 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06349200 id: 3197 briefTitle: Comparing Binaural Beats and 432Hz Music for Reduction of Preoperative Anxiety in Root Canal Patients overallStatus: RECRUITING date: 2024-03-27 date: 2024-06 date: 2024-07 date: 2024-04-05 date: 2024-04-12 name: Dow University of Health Sciences class: OTHER briefSummary: Many patients suffer from dental anxiety and don't go to dentists for regular checkups. This can lead to the initiation and progression of dental caries, which, if not controlled at the right time, can lead to the loss of the tooth itself. Many forms of distraction have been used to overcome this; music is also one of them. The main objective of this study is to compare the effectiveness of binaural beats and 432 Hz music in reducing preoperative dental unease and anxiety among adult patients undergoing root canal treatment in a dental teaching hospital. The null hypothesis is that both binaural beats and 432 Hz-frequency music are not effective in reducing preoperative dental anxiety among patients undergoing routine endodontic therapy in a dental teaching hospital. A total of three groups will be a part of this study, with a total sample size of 99 participants (33 participants in each group). Group A will listen to 432 Hz music for 10 minutes before the procedure, Group B will listen to binaural beats for 10 minutes before the procedure; and Group C (active control group) will listen to white noise for 10 minutes before the procedure. The Visual Analog Scale for Anxiety will be used to assess the anxiety levels before local anesthesia administration, after local anesthesia administration, and 10 minutes after listening to sounds. Then root canal treatment will be completed as a routine procedure. conditions: Dental Anxiety studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 99 type: ESTIMATED name: 432 Hz music name: Binaural beats name: White noise measure: Change in Pre-operative Dental Anxiety score using Visual Analog Scale for Anxiety sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Dow University of Health Sciences status: RECRUITING city: Karachi state: Sindh zip: 74200 country: Pakistan name: Dr. Hafsa Zaki role: CONTACT phone: +923462746052 email: hafsazaki99@hotmail.com name: Dr. Shahbaz Ahmed role: CONTACT phone: +923212000873 email: saj119@googlemail.com lat: 24.8608 lon: 67.0104 hasResults: False
nctId: NCT06349187 id: dsc002 briefTitle: Digital Competencies of the Doctors overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-05-10 date: 2024-06-10 date: 2024-04-05 date: 2024-04-05 name: Limited Liability Company "Docstarclub" class: OTHER briefSummary: The role of digital technologies in healthcare is growing. Therefore, the roles and responsibilities of medical professionals are constantly changing and there is a need for continuous professional development. However, according to some authors, today's generation of doctors can be considered as "digital aborigines" \[Aungst, Patel, 2020\]. Low literacy in the field of e-health has become a major obstacle to digital transformation in developed countries, so digital skills training for healthcare professionals has gradually been introduced in the USA \[Adler-Milstein, et al., 2014\], Europe \[Schreiweis, et al., 2019\], Australia \[Evolution of eHealth in Australia, 2016\].
Computerization and automation of the healthcare system began relatively recently, traditional (paper) document management in medicine is familiar to everyone, but not optimal from the point of view of system management. Therefore, universal digitalization is perceived as something artificially imposed, increasing the workload of doctors, distracting from their main work and shifting the focus from truly therapeutic activities to filling out documentation. As a result, doctors have a range of negative emotions: fear, annoyance, anxiety, despondency, refusal of further contacts, etc., which lead to an aggravation of emotional burnout. The ability to recognize and live through these states, to come to an inner balance, to accumulate an internal resource for further development of new technologies - all this is possible under the condition of the development of emotional intelligence. By developing so-called soft skills, the doctor will be emotionally stable, capable of further advancement and learning new skills, and will easily cope with temporary difficulties and setbacks.
The result of the development of a doctor within this model will be not only digital literacy, but also the development of an internally stable personality that easily overcomes any obstacles not only in training, but also in communication with patients and colleagues. conditions: Digital Competences conditions: Emotional Intelligence conditions: Emotional Burnout conditions: Doctor Patient Relation studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 500 type: ESTIMATED name: Interview measure: Completing the survey sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06349174 id: 2024-valve-1 briefTitle: Safety and Efficacy of Endobronchial Valve for Bronchoscopic Lung Volume Reduction Surgery: A Prospective Pilot Study overallStatus: NOT_YET_RECRUITING date: 2024-04-11 date: 2025-03-20 date: 2025-03-31 date: 2024-04-05 date: 2024-04-05 name: China-Japan Friendship Hospital class: OTHER briefSummary: The goal of this pliot study al is to preliminarily evaluate the effectiveness and safety of transbronchial lung volume reduction surgery using the self-devloped endobronchial valves for chronic obstructive pulmonary disease patients with emphysema phenotype . The main questions it aims to answer are: