hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06371313 id: GuangdongWCH-LiLi03 briefTitle: Endocrine, Metabolic and Inflammatory Characteristics of Offspring of Mothers With PCOS Hyperandrogenism overallStatus: COMPLETED date: 2023-05-01 date: 2024-03-05 date: 2024-03-05 date: 2024-04-17 date: 2024-04-17 name: Guangdong Women and Children Hospital class: OTHER briefSummary: This study is a cross-sectional study to explore the endocrine metabolism and inflammatory characteristics of the offspring of mothers with PCOS hyperandrogenism, in order to provide a theoretical basis for finding the cause of PCOS. conditions: PCOS studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 42 type: ACTUAL measure: Testosterone measure: Androstenedione measure: Dehydroepiandrosterone Sulfate measure: Sex Hormone Hinding Globulin measure: Free Androgen Index measure: Fasting Insulin measure: White Blood Cell Count measure: Neutrophil Count measure: High-sensitivity C-reactive Protein measure: Interleukin-6 sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Guangdong Women and Children Hosptial city: Guanzhou state: Guangdong zip: 511400 country: China hasResults: False
nctId: NCT06371300 id: HLS21156 briefTitle: Photobiomodulation With REd vs BluE Light (REBEL) overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-08 date: 2025-12 date: 2024-04-17 date: 2024-04-23 name: Aston University class: OTHER briefSummary: The use of photobiomodulation or low-level light therapy (LLLT) in the ophthalmic field stemmed from dermatology which has shown impact on skin blood flow and regeneration. There has been a rise in clinical interest with emerging evidence in the benefits of photobiomodulation in managing chronic inflammatory conditions such as dry eye disease including improvements in ocular discomfort symptoms, tear film stability and tear volume. Despite the observed clinical benefits, limited research has been done to compare photobiomodulation utilising different wavelengths, as most research on dry eye disease has focused on red wavelengths. It has been purported that blue wavelengths may disrupt microbial growth while red wavelengths stimulate energy production and hence increase heat in the affected tissues, although research into these differential impacts at the ocular surface and external eye has been limited. Hence, the aim of this exploratory clinical trial is to compare the impact of using LLLT incorporating red versus blue wavelengths on eyelid haemodynamics and microbiome, as well as conventional ocular surface measures of patients with dry eye disease and blepharitis (inflammation of the eyelids).
nctId: NCT06371287 id: 64696022.1.0000.5346 briefTitle: Effect of Musical Auditory Training on Subjects With Tinnitus Disorder overallStatus: RECRUITING date: 2023-02-20 date: 2024-08-10 date: 2025-02-10 date: 2024-04-17 date: 2024-04-24 name: Universidade Federal de Santa Maria class: OTHER briefSummary: Among the theories of tinnitus generation, there is that of central neuroplastic changes, which reports the association between changes and reorganization that occur in central auditory pathways and impacts on associated areas due to the altered neural signal. Auditory training modifies these altered pathways through auditory exercises, which provoke positive neuroplasticity. Musical auditory training is a proposal to stimulate auditory, cognitive and metalinguistic skills with activities focused on musicality. Therefore, the objective of this study is to verify the effect of musical auditory training (MAT) on the neuroplasticity of the auditory system and the perception of tinnitus disorder in young adults. conditions: Tinnitus studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: Treinamento Auditivo Musical name: Placebo measure: Changes in latency of the long latency auditory evoked potential (LLAEP) sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Universidade Federal de Santa Maria status: RECRUITING city: Santa Maria state: RS zip: 97.105-970 country: Brazil name: Dayane Domeneghini Didoné role: CONTACT phone: 553220-9362 email: dayane.didone@ufsm.br name: Dayane Domeneghini Didoné D Dayane Domeneghini Didoné role: PRINCIPAL_INVESTIGATOR lat: -29.68417 lon: -53.80694 facility: Universidade Federal de Santa Maria status: RECRUITING city: Santa Maria state: RS zip: 97.105-970 country: Brazil name: Dayane D Didoné, Professora role: CONTACT phone: 553220-9362 email: dayane.didone@ufsm.br name: Christine G Schumacher, Mestranda role: PRINCIPAL_INVESTIGATOR lat: -29.68417 lon: -53.80694 hasResults: False
nctId: NCT06371274 id: ZYYY-IIT-TNBC-001 briefTitle: A Study on the Efficacy and Safety of Oral All-trans Retinoic Acid Combined With Toripalimab in TNBC. overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-04-30 date: 2026-04-30 date: 2024-04-17 date: 2024-04-17 name: First Affiliated Hospital of Zhejiang University class: OTHER name: Shanghai Longfine Biotechnology Co., Ltd. name: TopAlliance briefSummary: To evaluate the clinical efficacy and safety of oral all-trans retinoic acid in combination with toripalimab in patients with locally advanced, recurrent, or metastatic triple-negative breast cancer who had failed second-line and subsequent therapy. conditions: Triple-negative Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 32 type: ESTIMATED name: ATRA name: Toripalimab measure: Objective Response Rate (ORR) measure: Progression-Free Survival (PFS) measure: Duration of Response (DOR) measure: Overall Survival (OS) measure: Incidence of Treatment-Emergent Adverse events as assessed by NCI-CTCAE 5.0 measure: Exploratory biomarkers-peripheral blood lymphocyte analysis measure: Exploratory biomarkers-Serum Metabolomics Analysis measure: Exploratory biomarkers-Fecal Microbiota Analysis sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The first affiliated hospital, Zhejiang University School of Medicine city: Hangzhou state: Zhejiang Province, P.R. China zip: 310003 country: China name: Meihua Lin, MS role: CONTACT name: Jian Liu, MS role: PRINCIPAL_INVESTIGATOR name: Xiaochen Zhang, MD role: PRINCIPAL_INVESTIGATOR lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06371261 id: 2023/CHU/07 briefTitle: Pathogenicity of Species of the Achromobacter Genus in Patients From Reunion Island With Cystic Fibrosis acronym: ACHROMO-MUCO overallStatus: RECRUITING date: 2024-02-29 date: 2027-03 date: 2027-03 date: 2024-04-17 date: 2024-04-26 name: Centre Hospitalier Universitaire de la Réunion class: OTHER briefSummary: The pathogenicity of Achromobacter bacteria is not yet well established, but studies show a decline in respiratory function and an increase in mortality associated with chronic colonisation, making it possible to classify the Achromobacter genus as an emerging pathogen in cystic fibrosis. It is possible that certain species or clones are more virulent or resistant, requiring the adaptation of measures to prevent cross-transmission in the centres concerned.
In view of the local epidemiology and the current lack of data, it would be necessary and interesting to use this tool to study a cohort of cystic fibrosis patients in Réunion island (North and South sites) to see whether one species has a greater clinical impact than another (pathogenicity), and/or is more responsible for chronic colonisation. conditions: Cystic Fibrosis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 35 type: ESTIMATED name: Biological analyses measure: Frequency of pulmonary exacerbations according to the species of the Achromobacter genus colonising/infecting cystic fibrosis patients. measure: Frequency of pulmonary exacerbations as a function of Achromobacter spp. colonisation status. measure: Emergence or existing presence of clones within the species of the genus Achromobacter circulating among cystic fibrosis patients in Réunion, using genomic analyses. measure: Presence of virulence factors in these strains using genomic analyses measure: Search for genes responsible for antibiotic resistance by genomic analysis of these strains measure: To describe the epidemiology of Achromobacter spp. in cystic fibrosis patients in Réunion sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: CHU la Réunion North status: RECRUITING city: Saint-Denis country: Réunion name: VERHILLE Juliette, MD role: CONTACT email: Juliette.verhille@chu-reunion.fr name: Juliette VERHILLE, MD role: PRINCIPAL_INVESTIGATOR lat: -20.88231 lon: 55.4504 facility: CHU la Réunion South status: RECRUITING city: Saint-Pierre country: Réunion name: PERISSON Caroline, MD role: CONTACT email: Caroline.perisson@chu-reunion.fr name: Caroline PERISSON, MD role: PRINCIPAL_INVESTIGATOR lat: -21.3393 lon: 55.47811 hasResults: False
nctId: NCT06371248 id: 2850 briefTitle: Steady Feet: Preventing Falls in the Community overallStatus: COMPLETED date: 2018-11-19 date: 2019-12-20 date: 2019-12-20 date: 2024-04-17 date: 2024-04-17 name: Changi General Hospital class: OTHER briefSummary: The purpose of this study is to examine the feasibility of Steady Feet, a three-month community-based falls prevention exercise program. conditions: Fall conditions: Feasibility conditions: Older Adults conditions: Exercise studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 65 type: ACTUAL name: Steady Feet name: Usual care for fall prevention measure: Short Physical Performance Battery (SPPB) measure: CONFbal measure: Six-minute walk test (6MWT) measure: Timed up and go (TUG) measure: Four square step test (FSST) measure: Feedback and satisfaction survey measure: Attendance and completion rates measure: Safety of Steady Feet sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Changi General Hospital city: Singapore zip: 529889 country: Singapore lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06371235 id: 2024-A00739-38 briefTitle: Study of the Transmission of Anti-interferon Type 1 Alpha Autoantibodies From Mother to Child Via the Placental Barrier acronym: Pregiferon overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2024-09 date: 2027-03 date: 2024-04-17 date: 2024-04-17 name: CerbaXpert class: OTHER briefSummary: The main objective of the study is to evaluate the frequency of placental transfer of self-Ab directed against the mother's IFN alpha in the newborn, in all women suffering from a pathology frequently associated with the presence of these autoantibodies and in those seropositive during the pregnancy. conditions: Woman Suffering From a Pathology Frequently Associated With the Presence of These Anti-autoantibodies Type-I Interferons studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 250 type: ESTIMATED name: Pregiferon measure: Frequency of placental transfer of self-Ab directed against IFN alpha from mother to newborn. sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06371222 id: BSMMU/2023/6502 briefTitle: Role of Ivabradine on Heart Rate and Quality of Life in Patients With Mitral Stenosis in Sinus Rhythm overallStatus: COMPLETED date: 2023-02-01 date: 2024-01-31 date: 2024-02-01 date: 2024-04-17 date: 2024-04-17 name: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh class: OTHER briefSummary: Mitral stenosis, a condition characterized by narrowing of the mitral valve orifice, remains a significant cause of morbidity and mortality worldwide, particularly in regions where rheumatic fever is endemic. Despite advancements in medical and surgical management, patients with mitral stenosis often suffer from symptoms such as dyspnea, fatigue, and reduced exercise tolerance, significantly impacting their quality of life (QoL) \[1\].
In recent years, ivabradine, a selective inhibitor of the If current in the sinoatrial node, has emerged as a promising therapeutic option for controlling heart rate in various cardiovascular conditions, including chronic heart failure and ischemic heart disease \[3\]. By specifically targeting the cardiac pacemaker cells, ivabradine reduces heart rate without affecting myocardial contractility or conduction, offering a unique mechanism of heart rate control compared to traditional beta-blockers or calcium channel blockers \[4\].
However, the role of ivabradine in patients with mitral stenosis in sinus rhythm remains uncertain, and there is limited evidence regarding its efficacy and impact on QoL in this specific patient population. Therefore, the aim of this randomized controlled trial (RCT) is to investigate the effects of ivabradine on heart rate control and QoL in patients with mitral stenosis in sinus rhythm. conditions: Mitral Stenosis studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: RCT primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 42 type: ACTUAL name: Ivabradine name: Beta blocker measure: effect of ivabradine in MS patients measure: quality of life of MS patients sex: ALL minimumAge: 17 Years maximumAge: 80 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: BSMMU city: Dhaka zip: 1200 country: Bangladesh lat: 23.7104 lon: 90.40744 hasResults: False
nctId: NCT06371209 id: 2022P000619 briefTitle: Kinematics of Ewing Amputees overallStatus: ENROLLING_BY_INVITATION date: 2022-05-17 date: 2024-06-29 date: 2024-07-01 date: 2024-04-17 date: 2024-04-17 name: Brigham and Women's Hospital class: OTHER briefSummary: The agonist-antagonist myoneural interface (AMI) construct, known as the Ewing amputation at the trans-tibial level, has been shown to create a bi-directional neural communication platform as a means of controlling and interpreting proprioceptive feedback from a prosthetic joint. In AMI constructs, agonist-antagonist muscles are mechanically coupled within the residual limb, and volitional contraction of an agonist passively stretches that muscle's antagonist. The natural neural responses from muscle spindles within both muscles are then interpreted by the central nervous system as sensations of joint position and speed, associated with movement of the prosthesis.
The investigators hypothesize that the affected limb of patients with the Ewing procedure will demonstrate a pattern of electromyographic activation of their AMI constructs and kinematic data that recapitulates the pattern seen in their intact limb. The investigators secondarily hypothesize that the kinematic assessment of Ewing Amputation patients will demonstrate patterns that are significantly more physiologic than those witnessed in similar assessments of standard amputees. conditions: Lower Extremity Amputation conditions: Trans-Tibial Amputation conditions: Traumatic Lower Extremity Amputation conditions: Agonist-Antagonist Myoneural Interface studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 32 type: ESTIMATED name: Modified Amputation name: Standard Amputation measure: Duration of co-contraction of the ankle dorsi/plantar-flexor muscles during gait measure: Symmetry of duration of co-contraction of the ankle dorsi/plantar-flexor muscles during gait measure: Symmetry of ankle power generation measure: Symmetry of peak knee flexion during stance measure: Symmetry of step length sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mass General Brigham city: Boston state: Massachusetts zip: 02129 country: United States lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06371196 id: BBD-PBC 2024-03 briefTitle: Clinical Study on the Treatment of Elevated Total Bilirubin in Primary Biliary Cholangitis With Baobao Dan Capsule overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2025-07-25 date: 2025-12-31 date: 2024-04-17 date: 2024-04-17 name: Mei Han class: OTHER briefSummary: 1. Explore the effect of Babaodan Capsule on the serum total bilirubin level of primary biliary cholangitis patients with elevated total serum bilirubin;
2. To observe the positive intervention effect of Babaodan Capsule on the clinical symptoms of primary biliary cholangitis patients with elevated total bilirubin. conditions: Primary Biliary Cholangitis studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Babaodan Capsule measure: Total bilirubin (TBil) reversion rate measure: Total bilirubin (TBil) efficacy rate measure: biological response rate measure: ALT measure: AST measure: ALP measure: TBA measure: DBil measure: IBil measure: 5-D Pruritus Scale Score measure: Fatigue section of the PBC-40 questionnaire measure: Immunological indicators - serum IgM measure: Immunological indicators - serum IgG measure: Immunological indicators - serum IgA measure: Immunological indicators - anti-gp210 antibody measure: Immunological indicators - anti-sp100 antibody measure: Immunological indicators - autoantibodies AMA/AMA-M2 measure: Histopathology of the liver - grading of inflammatory activity measure: Histopathology of the liver - staging of the degree of fibrosis measure: 12-lead electrocardiogram measure: Physical examination measure: Routine blood test measure: Renal Function Tests-BUN measure: Renal Function Tests-UA measure: Renal Function Tests-Scr measure: Urinalysis measure: Coagulation tests-PT measure: Coagulation tests-APTT measure: Coagulation tests-TT measure: Coagulation tests-FIB measure: Urine beta-hCG pregnancy test measure: adverse event measure: Body temperature measure: Heart rate measure: Number of breaths in 1 min measure: Blood pressure-Diastolic blood pressure(mmHg) measure: Blood pressure-Systolic blood pressure(mmHg) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06371183 id: AOMSaidB briefTitle: A Comparative Study of Clinical, Endoscopic and Histopathological Features of Colitis in Children on June 2024 overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-05-30 date: 2027-05-30 date: 2024-04-17 date: 2024-04-17 name: Assiut University class: OTHER briefSummary: A Comparative study of clinical, endoscopic and histopathological features of colitis in children conditions: Role of Ileoscopy in Diagnosis of Colitis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Patients who complaining of lower GI manifestations primaryPurpose: DIAGNOSTIC masking: NONE count: 196 type: ESTIMATED name: Colonoscope measure: Role of ileoscopy in diagnosis of colitis measure: To correlate clinical manifestations by colonoscopic picture sex: ALL minimumAge: 1 Month maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06371170 id: CCPC- 001/22 briefTitle: Rivaroxaban for Intracardiac Thrombosis in the Pediatric Population overallStatus: RECRUITING date: 2023-01-01 date: 2025-01-01 date: 2027-01-01 date: 2024-04-17 date: 2024-04-19 name: Azienda Ospedaliero, Universitaria Ospedali Riuniti class: OTHER briefSummary: The goal of this observational study is to determine the efficacy of rivaroxaban treatment for intracardiac thrombi resolution in pediatric patients (\< 16 years old) diagnosed with intracardiac thrombosis. The main question it aims to answer is: Does rivaroxaban treatment resolve the thrombosis during a 3-month treatment?
Participants already taking rivaroxaban as part of their regular medical care for thrombosis resolution. They will undergo monthly visits to check that the treatment is progressing correctly and that no major bleeding has occurred. After 3 months of treatment, they will repeat the radiological imaging investigation to verify the actual resolution of the thrombosis. conditions: Intracardiac Thrombus studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED name: Rivaroxaban measure: Thrombus resolution measure: Bleeding sex: ALL minimumAge: 1 Month maximumAge: 16 Years stdAges: CHILD facility: CCPC status: RECRUITING city: Ancona state: Marche zip: 60123 country: Italy name: Francesco Bianco, M.D. role: CONTACT phone: +39 071 596 5316 email: francesco.bianco@ospedaliriuniti.marche.it lat: 43.5942 lon: 13.50337 hasResults: False
nctId: NCT06371157 id: AK104-308 briefTitle: A Study of AK104+Lenvatinib in Combination With Transarterial Chemoembolization (TACE) Versus TACE in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma overallStatus: NOT_YET_RECRUITING date: 2024-07-02 date: 2025-10-25 date: 2026-05-23 date: 2024-04-17 date: 2024-04-17 name: Akeso class: INDUSTRY briefSummary: A study to evaluate cadonilimab (AK104) + lenvatinib in combination with transarterial chemoembolization (TACE) versus TACE in participants with incurable/non-metastatic hepatocellular carcinoma conditions: Hepatocellular Carcinoma studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 469 type: ESTIMATED name: AK104 name: Lenvatinib name: TACE name: Placebo for AK104 name: Placebo for Lenvatinib measure: Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) measure: Overall Survival (OS) measure: PFS per RECIST 1.1 measure: Objective Response Rate (ORR) per RECIST 1.1 and Modified Response Evaluation Criteria in Solid Tumors (mRECIST) measure: Duration of Response (DOR) per RECIST 1.1 and mRECIST measure: Disease Control Rate (DCR) per RECIST 1.1 and mRECIST measure: Time to Response (TTR) per RECIST 1.1 and mRECIST sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Henan Cancer Hospital city: Zhengzhou state: Henan zip: 450004 country: China name: Hailiang Li role: CONTACT lat: 34.75778 lon: 113.64861 facility: Hunan Cancer Hospital city: Changsha state: Hunan zip: 410006 country: China name: Shanzhi Gu role: CONTACT lat: 28.19874 lon: 112.97087 facility: Zhongda Hospital Southeast University city: Nanjing state: Jiangsu zip: 210009 country: China name: Gaojun Teng role: CONTACT lat: 32.06167 lon: 118.77778 facility: Shanxi Cancer Hospital city: Taiyuan state: Shanxi zip: 030009 country: China lat: 37.86944 lon: 112.56028 facility: Sichuan Cancer Hospital city: Chengdu state: Sichuan zip: 610041 country: China lat: 30.66667 lon: 104.06667 facility: Yunnan Cancer Hospital city: Kunming state: Yunnan zip: 650100 country: China lat: 25.03889 lon: 102.71833 facility: Zhejiang Cancer Hospital city: Hangzhou state: Zhejiang zip: 310005 country: China name: Guoliang Shao role: CONTACT lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06371144 id: NHREC/16/05/22/130 briefTitle: A Randomized Control Trial on Intravenous Paracetamol Versus Intramuscular Tramadol as Intra Partum Labor Analgesia overallStatus: COMPLETED date: 2022-06-03 date: 2022-09-10 date: 2022-09-10 date: 2024-04-17 date: 2024-04-17 name: Darlington-Peter Chibuzor Ugoji class: OTHER briefSummary: ABSTRACT BACKGROUND: Labor pain is one of the most excruciating pain experienced by women. It affects maternal psychology and the course of labor causing apprehension, anxiety, and stress. Therefore there is a need for a safe and effective analgesic with minimal maternal and fetal side effects like intravenous paracetamol which has been shown to have great analgesic effect in labour with minimal maternal and neonatal side effects.