hackint0sh/New-Dataset huggingface dataset:
* In a subset of subjects, the amount of NORA520 in breastmilk at various times after taking it to determine if and how much NORA520 can pass into breastmilk Participate in this study will be randomly assigned to one of 3 different groups. All subjects will take the study drug for 3 days. conditions: Depression, Postpartum conditions: Postpartum Depression conditions: Post-partum Depression conditions: Postnatal Depression conditions: Post-Natal Depression studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: NORA520 Dose 1 name: NORA520 Dose 2 name: Placebo measure: Incidence, severity, and causality of AEs, SAEs, and AESIs measure: Change from baseline in HAM-D17 total score compared to placebo measure: Change from baseline in HAM-D17 total score measure: HAM-D17 response measure: HAM-D17 remission measure: Change from baseline in HAM-D17 subscale and individual item scores measure: Change from baseline in Clinical Global Impression - Severity (CGI-S) score measure: Clinical Global Impression - Improvement (CGI-I) scale positive response measure: Change from baseline in Montgomery-Åsberg Depression Rating Scale (MADRS) total score measure: Change from baseline in Hamilton Anxiety Rating Scale (HAM-A) total score measure: Change from baseline in Edinburgh Postnatal Depression Scale (EPDS) total score measure: Number of patients who start any new antidepressant or anti-anxiety medication sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Gerbera site city: Canoga Park state: California zip: 91304 country: United States lat: 34.20112 lon: -118.59814 facility: Gerbera sites city: Miami Gardens state: Florida zip: 33014 country: United States lat: 25.94298 lon: -80.24452 facility: Gerbera site city: Orlando state: Florida zip: 32807 country: United States lat: 28.53834 lon: -81.37924 facility: Gerbera site city: Saint Petersburg state: Florida zip: 33607 country: United States lat: 27.77086 lon: -82.67927 facility: Gerbera site city: League City state: Texas zip: 77573 country: United States lat: 29.50745 lon: -95.09493 facility: Gerbera site city: Richardson state: Texas zip: 75080 country: United States lat: 32.94818 lon: -96.72972 hasResults: False
nctId: NCT06285903 id: AUAREC20220002-11 briefTitle: Comparing the Hydrodynamic Piezoelectric Technique With Osseodensification for the Assessment of Internal Sinus Iift-ing acronym: RCT overallStatus: COMPLETED date: 2022-09-02 date: 2022-12-01 date: 2023-12-30 date: 2024-02-29 date: 2024-03-28 name: Al-Azhar University class: OTHER briefSummary: Successful osseointegration considered the cornerstone in implant stability which predict the highest implants success outcomes. Implant stability depend on many factors like the implant design, surgical technique, and bone density. Posterior maxilla considered as a challenging area in implant placement, this is due to less dense trabecular bone sur-rounded by a thin layer of cortical bone which result in suffering in implant stability. The aim of this study is to evaluate the bone density outcomes using bone densification technique and piezoelectric surgical technique in sinus lift to promote bone gain conditions: Bone Density, Low studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A total of 20 patients were randomly divided into two groups: Group1: patients received dental implant using osseodensification via Densah bur, Group2: patients received dental implant using hydrodynamic piezoelectric sinus lifting. The patients in both groups underwent bone grafting under sinus membrane. Modified bleeding index and probing depth were evaluated at 3, 6 and 12months intervals. An Osstell device was used to de-termine implant stability by recording the values of implant stability quotient (ISQ) im-mediately after implant placement and after 3 months. CBCT was performed before, af-ter 6 months and after 12 months to evaluate ridge height, bone density. Marginal bone loss was evaluated after 3 months via periapical radiograph, after 6 months and after 12 months via CBCT. primaryPurpose: TREATMENT masking: NONE count: 20 type: ACTUAL name: internal sinus lift surgery measure: Implant stability using the Osstell device by percentage measure: Modified sulcus bleeding index,Peri-implant pocket depth (PPD)by mm measure: Bone Densityby mm sex: ALL minimumAge: 35 Years maximumAge: 39 Years stdAges: ADULT facility: Alazhar university ,Assuit branch ,Egypt city: Assiut state: Assuit zip: 0000 country: Egypt lat: 27.18096 lon: 31.18368 hasResults: False
nctId: NCT06285890 id: 2023-1016 id: NCI-2024-01733 type: OTHER domain: NCI-CTRP Clinical Registry briefTitle: Phase I Study of HC-7366 With Azacitidine and Venetoclax for Acute Myeloid Leukemia overallStatus: NOT_YET_RECRUITING date: 2024-08-31 date: 2027-12-31 date: 2029-12-31 date: 2024-02-29 date: 2024-04-12 name: M.D. Anderson Cancer Center class: OTHER name: HiberCell, Inc. briefSummary: To find a recommended dose of HC-7366 that can be given in combination with azacitidine and venetoclax to patients with AML. The safety and effects of this drug combination will also be studied. conditions: Acute Myeloid Leukemia studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 18 type: ESTIMATED name: HC-7366 name: Azacitidine name: Venetoclax measure: Safety and adverse events (AEs) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: MD Anderson Cancer Center city: Houston state: Texas zip: 77030 country: United States name: Abhishek Maiti, MD role: CONTACT phone: 346-725-0901 email: amaiti@mdanderson.org name: Abhishek Maiti, MD role: PRINCIPAL_INVESTIGATOR lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06285877 id: 291120234382023 briefTitle: Effectiveness of the Use of the Nintendo Switch Combined With Conventional Therapy in People With Acquired Brain Injury overallStatus: RECRUITING date: 2024-02 date: 2024-02 date: 2025-01 date: 2024-02-29 date: 2024-02-29 name: Universidad Rey Juan Carlos class: OTHER briefSummary: Purpose: to observe the possible benefits produced by conventional therapy through virtual reality with the Nintendo Switch to try to improve motivation and increase the degree of care satisfaction. The aim is to improve postural control in both seated and standing positions and to maintain and improve cognitive capacity.
Measures: Abilhand, MEC-Lobo, FIST, Fugl-Meyer, Berg Balance Scale and CSQ-8. conditions: Occupational Therapy conditions: Acquired Brain Injury conditions: Adults studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Control Group (CG), which received their usual sessions of conventional therapy sessions, and an Experimental Group (EG), which received therapy with Nintendo Switch plus their conventional therapy sessions. primaryPurpose: TREATMENT masking: NONE count: 32 type: ESTIMATED name: Conventional therapy sessions name: Conventional therapy sessions plus Nintendo Switch measure: Abilhand measure: MEC-Lobo measure: Function in Sitting Test (FIST) measure: Fugl-Meyer measure: Berg Balance Scale (BBS) measure: Client Satisfaction Questionnaire (CSQ-8) sex: ALL minimumAge: 30 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Universidad Rey Juan Carlos status: RECRUITING city: Móstoles state: Madrid zip: 28933 country: Spain name: Isabel Quirosa Galan, MsC role: CONTACT phone: +34655551210 email: i.quirosa.2016@alumnos.urjc.es lat: 40.32234 lon: -3.86496 hasResults: False
nctId: NCT06285864 id: 122/2023 briefTitle: Sense to Act: An Interoceptive Sensibility Intervention for Musculoskeletal Pain overallStatus: RECRUITING date: 2024-02 date: 2024-06 date: 2024-12 date: 2024-02-29 date: 2024-03-01 name: Iscte-University Institute of Lisbon class: OTHER name: Foundation for Science and Technology (FCT) name: University of Évora briefSummary: The ability to be connected and act according to bodily information is fundamental in chronic pain adjustment. This study aims to test the feasibility of an intervention designed to improve interoceptive sensibility, i.e., the ability to sense, interpret, and regulate bodily sensations in chronic musculoskeletal pain patients. conditions: Musculoskeletal Pain conditions: Chronic Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Participants will be unaware of their assigned treatment. whoMasked: PARTICIPANT count: 70 type: ESTIMATED name: Interoception-based intervention measure: Feasibility - Sessions' acceptability measure: Feasibility - Program acceptability, appropriateness, and feasibility measure: Feasibility - Recruitment, retention, and attendance rates measure: Feasibility - safety/unexpected events measure: Feasibility - Treatment Fidelity Check measure: Interoceptive sensibility measure: Psychological flexibility measure: Emotion regulation measure: Pain-related self-efficacy measure: Pain catastrophizing measure: Activity patterns measure: Affective distress (depression and anxiety) measure: Pain severity measure: Physical function and Vitality sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Iscte - University Institute of Lisbon status: RECRUITING city: Lisbon zip: 1649-026 country: Portugal name: Inês Oliveira, MSc role: CONTACT phone: +351217903000 email: iamoa@iscte-iul.pt name: Sónia Bernardes, PhD role: CONTACT phone: +351217903000 email: sonia.bernardes@iscte-iul.pt name: Inês Oliveira, MSc role: PRINCIPAL_INVESTIGATOR lat: 38.71667 lon: -9.13333 facility: University of Évora status: RECRUITING city: Évora zip: 7004-516 country: Portugal name: Inês Oliveira, MSc role: CONTACT phone: +351266740800 email: iamoa@iscte-iul.pt name: Sónia Bernardes, PhD role: CONTACT phone: +351217903000 email: sonia.bernardes@iscte-iul.pt name: Inês Oliveira, MSc role: PRINCIPAL_INVESTIGATOR lat: 38.56667 lon: -7.9 hasResults: False
nctId: NCT06285851 id: 23-0825 briefTitle: A Novel Iron Supplement for Athletes: Phase I overallStatus: COMPLETED date: 2023-11-23 date: 2023-12-12 date: 2023-12-12 date: 2024-02-29 date: 2024-03-28 name: University of Calgary class: OTHER name: Lallemand Bio-Ingredients briefSummary: Female endurance athletes are susceptible to iron deficiency and this can impact their exercise performance. This study is a pilot trial to assess the tolerability of a novel iron supplement prior to conducting a clinical trial on the efficacy of the developed novel iron supplement on iron status and performance. conditions: Constipation conditions: Diarrhea conditions: Cramp, Abdominal conditions: Bleeding Gastric studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 14 type: ACTUAL name: FeSC measure: GI Symptoms measure: Gastrointestinal symptoms measure: Supplement Tolerability and Preferences Questionnaire measure: Recovery sex: FEMALE minimumAge: 18 Years maximumAge: 25 Years stdAges: ADULT facility: University of Calgary city: Calgary state: Alberta country: Canada lat: 51.05011 lon: -114.08529 hasResults: False
nctId: NCT06285838 id: 2020/2706 briefTitle: Impact of Measures Taken to Contain COVID-19 on Hospital Surgical Care Services and Clinical Outcomes overallStatus: COMPLETED date: 2020-07-17 date: 2023-11-30 date: 2024-01-20 date: 2024-02-29 date: 2024-02-29 name: Singapore Health Services class: OTHER briefSummary: Swift and decisive actions on the part of healthcare and hospital authorities are required to effectively contain the current COVID-19 pandemic. These measures firstly allow personnel and facilities leeway to provide surge capabilities to meet anticipated increased demands on the healthcare service. In addition, by deferring none urgent hospital visits, admissions and investigations, such measures support social distancing and aid attempts to control disease transmission. Deferring perceived non-urgent patient services may however lead to unintended delayed diagnoses and exacerbation of current patient conditions and lead to increased emergency admissions and surgeries.
The surgical philosophy during this period was that a judicious policy that allowed surgeons to proceed with surgery deemed critical but to postpone those deemed less so will at the system level, avoid poor outcomes for patients who required surgery and yet successfully re-allocate resources required to address the unfolding pandemic. conditions: COVID-19 studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 11000 type: ACTUAL measure: Impact of measures taken to contain COVID-19 on hospital surgical care services and clinical outcomes sex: ALL minimumAge: 21 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Singapore Health Services Pte ltd city: Singapore zip: 169856 country: Singapore lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06285825 id: 2023-0864 id: NCI-2024-01736 type: OTHER domain: NCI-CTRP Clinical Registry briefTitle: A Pilot Study of Emapalumab for the Treatment of CAR T-Cell Therapy-Associated Prolonged Cytopenia overallStatus: NOT_YET_RECRUITING date: 2024-07-31 date: 2026-08-22 date: 2028-08-22 date: 2024-02-29 date: 2024-03-13 name: M.D. Anderson Cancer Center class: OTHER name: Sobi, Inc. briefSummary: To look at the safety and effectiveness of emapalumab for the treatment of prolonged severe cytopenia in participants with LBCL who receive CART. conditions: Cytopenia studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 32 type: ESTIMATED name: Emapalumab measure: Safety and adverse events (AEs) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: MD Anderson Cancer Center city: Houston state: Texas zip: 77030 country: United States name: Paolo Strati, MD role: CONTACT phone: 713-745-1776 email: pstrati@mdanderson.org name: Paolo Strati, MD role: PRINCIPAL_INVESTIGATOR lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06285812 id: 000003 briefTitle: Otitis Treatment With OtoSight™ - Modification of Antibiotic Treatment Intervention in Children acronym: OTO-MATIC overallStatus: RECRUITING date: 2023-01-10 date: 2024-05-30 date: 2024-05-30 date: 2024-02-29 date: 2024-02-29 name: PhotoniCare, Inc. class: INDUSTRY name: TTi Health Research & Economics briefSummary: A pragmatic, mixed-method trial is to show the ability of OtoSight to change management of the pediatric patient presenting with ear pain in a way that improves patient outcomes and reduces costs. conditions: Otitis Media Acute studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 700 type: ESTIMATED name: OtoSight Middle Ear Scope measure: Change the clinician rate of antibiotic prescriptions measure: Change the number of antibiotic rounds per patient measure: Change costs associated with management of pediatric patients presenting with ear-related pain measure: Change in unnecessary antibiotic prescriptions measure: Change in prescription adherence measure: Change in antibiotic prescription rate when fluid not present measure: Improve patient outcomes measure: Change medical resource utilization measure: Change unnecessary medical intervention measure: Impact clinician confidence measure: Impact caregiver satisfaction measure: Change in Health-related Quality of Life (HQoL) sex: ALL minimumAge: 6 Months maximumAge: 17 Years stdAges: CHILD facility: Children's National Hospital status: NOT_YET_RECRUITING city: Washington state: District of Columbia zip: 20010 country: United States name: Bobbe Thomas role: CONTACT lat: 38.89511 lon: -77.03637 facility: Trillim Health status: RECRUITING city: Rochester state: New York zip: 14620 country: United States name: Shealynn Hilliard role: CONTACT lat: 43.15478 lon: -77.61556 facility: Cyn3rgy Research status: RECRUITING city: Gresham state: Oregon zip: 97030 country: United States name: Allie Calaman role: CONTACT lat: 45.49818 lon: -122.43148 facility: Carolina ENT status: RECRUITING city: Orangeburg state: South Carolina zip: 29118 country: United States name: Simone Ansley role: CONTACT lat: 33.49182 lon: -80.85565 hasResults: False
nctId: NCT06285799 id: IHAT_ID_2024 briefTitle: Safety and Effectiveness of Iron Hydroxide Adipate Tartrate (IHAT) in Iron Deficient Premenopausal Women overallStatus: RECRUITING date: 2024-03-05 date: 2025-12-01 date: 2025-12-31 date: 2024-02-29 date: 2024-04-19 name: Nemysis Ltd class: INDUSTRY name: RDC Clinical Pty Ltd briefSummary: This is a double blind, randomised, placebo-controlled trial to evaluate orally-dosed Iron Hydroxide Adipate Tartrate (IHAT) at 2 different dose levels compared to placebo for increasing serum ferritin levels in iron deficient, but otherwise healthy premenopausal women over 12 weeks. conditions: Iron-deficiency studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 180 type: ESTIMATED name: Low Dose IHAT name: High Dose IHAT name: Carob Flour measure: Percentage of women recovering from iron deficiency at week 12 measure: Time to reach normalisation of ferritin levels measure: Change in iron status measure: Change in fatigue measure: Incidence and prevalence of gastrointestinal side effects measure: Iron deficiency symptoms sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: RDC Clinical Pty Ltd status: RECRUITING city: Brisbane state: Queensland zip: 4006 country: Australia name: Amanda Rao, PhD role: CONTACT phone: +61 414 488 559 email: amanda@rdcglobal.com.au name: David Briskey, PhD role: CONTACT phone: +61 421 784 077 email: david@rdcglobal.com.au name: Amanda Rao, PhD role: PRINCIPAL_INVESTIGATOR lat: -27.46794 lon: 153.02809 hasResults: False
nctId: NCT06285786 id: REB 2023-109 briefTitle: Patient Handling Techniques and New Technology for Health Care Workers overallStatus: RECRUITING date: 2023-09-20 date: 2024-03-15 date: 2024-04-20 date: 2024-02-29 date: 2024-02-29 name: University of New Brunswick class: OTHER briefSummary: Patient handling is a major risk-factor for the development of musculoskeletal injuries in healthcare providers. To have a significant impact on injury reduction related to patient handling will require the incorporation of technology. This project is to investigate a piece of technology that has been designed to facilitate in-bed patient handling: The Vendlet.
The project will provide a biomechanical comparison of commonly used patient handling techniques performed using a SAMS bed outfitted with and without a Vendlet patient transfer device. This Vendlet technology has the potential to significantly reduce the musculoskeletal and joint strain of healthcare providers while handling patients. conditions: Work-related Injury studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: One single group of participants will be performing the same patient handling tasks:
2. During session 2 (Post-Intervention) participants will be asked to perform the patient handling techniques as seen during the intervention on both beds. primaryPurpose: BASIC_SCIENCE masking: NONE maskingDescription: Participants will be masked of the proper technique/training during the pre-intervention session (with and without the use of technology). Specifically, on how to manually move the patient in both beds. count: 30 type: ESTIMATED name: Ergonomic Training on Patient Handling Techniques measure: Neuromuscular Activity - Average muscle activation measure: Neuromuscular Activity - Peak muscle activation measure: Motion Capture: To assess postural changes in patient handling technique. measure: Motion Capture: To assess cumulative load forces measure: Motion Capture: To assess joint angles measure: Foot Pressure Distribution: Peak pressure will be the outcome measure of interest to assess postural balance and stability of the participant performing the patient handling technique. measure: Foot Pressure Distribution: Contact area will be the outcome measure of interest to assess postural balance and stability of the participant performing the patient handling technique. measure: Bed Pressure Distribution: Average pressure distribution will be outcome measures to assess the safe placement of the patient. measure: Bed Pressure Distribution: Peak pressure distribution will be outcome measures to assess the safe placement of the patient. measure: Self Reported Questionnaires measure: Exit Survey measure: Rating of Perceived Exertion (RPE) sex: ALL minimumAge: 17 Years maximumAge: 40 Years stdAges: CHILD stdAges: ADULT facility: Universite de Moncton status: RECRUITING city: Moncton state: New Brunswick zip: E1A 3E9 country: Canada name: Dre. Michelle Cardoso, PhD, Doctorate role: CONTACT phone: 506-470-3979 email: michelle.cardoso@umoncton.ca lat: 46.09454 lon: -64.7965 hasResults: False
nctId: NCT06285773 id: Medipol Hospital 36 briefTitle: Recto-intercostal Fascial Plane Block and Pecto-intercostal Fascial Plane Block for Cardiac Surgery overallStatus: RECRUITING date: 2024-02-25 date: 2024-10-20 date: 2024-11-10 date: 2024-02-29 date: 2024-02-29 name: Medipol University class: OTHER briefSummary: In cardiac surgeries performed with median sternotomy, mediastinal and thoracic tube placement sites are outside the area of effect of parasternal blocks, and sometimes the sternotomy incision extends below the T6 dermatome. Recto intercostal fascial plane block (RIFPB) has been defined as a complementary block for analgesia of this region. This study aims to evaluate the effectiveness of the combination of ultrasound-guided recto-intercostal fascial plane block and pectointercostal fascial block for postoperative analgesia management after open heart surgery (coronary artery bypass) with median sternotomy. conditions: Cardiac Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Sixty patients aged 18-65 years old with American Society of Anesthesiologists (ASA) classification I-II and scheduled for open heart surgery (coronary artery bypass) with median sternotomy will be included in the study. Patients will be randomly divided into two groups (Group PR = PIFPB + RIFPB group, Group C = Control group) including 30 patients each, before entering the operating room. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Outcomes Assessor and participant were blinded to the study whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: RIFPB block name: Postoperative analgesia management name: PIFPB block measure: Global recovery scoring system / Quality of Recovery 15 questionairre measure: Postoperative pain scores (Numerical rating scale) (0-meaning "no pain" to 10-meaning "worst pain imaginable") measure: The use of rescue analgesia measure: The use of rescue analgesia sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istanbul Medipol University Hospital status: RECRUITING city: Istanbul state: Bagcilar zip: 34070 country: Turkey name: Bahadir Ciftci, MD role: CONTACT phone: +905325034428 email: bciftci@medipol.edu.tr lat: 41.01384 lon: 28.94966 hasResults: False