hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06272032 id: 2023KFKT001 briefTitle: Prospective Multicenter Observational Study and Promotion of the Application of Focused Ultrasound in Allergic Rhinitis overallStatus: RECRUITING date: 2023-08-01 date: 2025-07-31 date: 2025-07-31 date: 2024-02-22 date: 2024-02-22 name: Chongqing Medical University class: OTHER briefSummary: Allergic rhinitis (AR) is a common condition, with nearly 300 million affected individuals in China, significantly impacting the quality of life. Despite standardized drug treatments, approximately 20% of AR patients experience inadequate control and require surgical intervention. AR manifests as nasal itching, sneezing, clear nasal discharge, nasal congestion, primarily associated with inflammation-induced hypertrophy of nasal turbinates and a heightened neurogenic state of the nasal mucosa. Surgical treatment focuses on "reducing hypertrophy" of nasal turbinates and "desensitizing" neurogenic hyperreactivity.High-intensity focused ultrasound (HIFU), as a minimally invasive therapeutic modality in AR, is still in its early stages of application and requires further multicenter clinical studies and widespread adoption. This project collaborates with six established institutions proficient in ultrasound treatment for AR. It aims to conduct a prospective multicenter observational study and subsequent dissemination, emphasizing the application of "reduction of hypertrophy" and "desensitization" in AR.Through standardized case selection, subjective and objective measures such as subjective symptom scores, quality of life assessments, nasal reflex, and nasal resistance tests before and after treatment will be employed to evaluate the effectiveness and safety of HIFU in "reducing hypertrophy" and "desensitizing" aspects of AR. Simultaneously, building on our established Otolaryngology Head and Neck Surgery Alliance and Southwest Allergy Alliance, the research results will be promoted through lectures, hands-on guidance, training sessions, academic conferences, and other means to facilitate the application of HIFU in AR and benefit a larger population of AR patients. conditions: Allergic Rhinitis studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 240 type: ESTIMATED name: High-intensity focused ultrasound (HIFU) name: intranasal corticosteroids, oral antihistamines, oral leukotriene receptor antagonists, and intranasal antihistamines measure: Nasal Symptom Score measure: daily medication score sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chongqing Medical University status: RECRUITING city: Chongqing state: Chongqing country: China name: Shen Yang, Doctoral role: CONTACT phone: 15111953398 email: sy_smile@sina.cn lat: 29.56278 lon: 106.55278 hasResults: False
nctId: NCT06272019 id: HREC-DCU 2023-074 briefTitle: Alternative Application Methods of Pre-procedural Povidone Iodine Mouthrinse overallStatus: COMPLETED date: 2023-09-01 date: 2024-04-20 date: 2024-04-20 date: 2024-02-22 date: 2024-04-23 name: Chulalongkorn University class: OTHER briefSummary: To compare the iodine remaining in saliva between gargle method and swab method conditions: The Retention of Iodine in Saliva Over the Time conditions: The Comparison of Iodine in Saliva Between Gargle and Swab studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: the participant will use iodine gargle in 2 method primaryPurpose: PREVENTION masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 25 type: ACTUAL name: Iodine gargle measure: The rate of retention of iodine in saliva measure: The comparison of the retention of iodine between gargle and swab sex: ALL minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Faculty of Dentistry, Chulalongkorn University city: Bangkok country: Thailand lat: 13.75398 lon: 100.50144 hasResults: False
nctId: NCT06272006 id: Anatomical recession briefTitle: The Comparison of Different Root Coverage Techniques Using the Anatomical Recession Area Approach overallStatus: NOT_YET_RECRUITING date: 2024-02-24 date: 2025-03-04 date: 2025-04-05 date: 2024-02-22 date: 2024-02-22 name: Hacettepe University class: OTHER briefSummary: The goal of this clinical trial is to compare the effectiveness of two treatments for gingival recession. The main questions it aims to answer are:
The patients will be treated with coronally advanced flap or modified coronally advanced tunnel + connective tissue graft to see which method is more effective in reducing gum recession, as measured by using anatomical recession rate. conditions: Gingival Recession studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This randomized controlled trial compares two gingival recession treatments: Coronally Advanced Flap (CAF) with Connective Tissue Graft (CTG) versus Modified Coronally Advanced Tunnel (MCAT) with CTG. Participants are randomized 1:1 to either intervention. Outcomes assessors are blinded to allocation, ensuring unbiased evaluation of the primary outcome, Anatomical Recession Rate (ARR), and secondary clinical outcomes over a 12-month follow-up. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: This study implements single-blind masking where outcomes assessors are unaware of participants' group assignments to minimize bias. While blinding participants and care providers is not feasible due to the nature of surgical interventions, strict protocols ensure assessors remain blinded to treatment allocation throughout the study, enhancing outcome evaluation objectivity. whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: Coronally Positioned Flap with Connective Tissue Graft name: Modified Coronally Advanced Tunnel with Connective Tissue Graft measure: Anatomical Recession Rate (ARR) measure: Clinical Attachment Level (CAL) measure: Gingival Thickness (GT) measure: Keratinized Tissue Thickness (KTT) measure: Wound healing index (WHI) measure: Tissue appearance measure: Aesthetic evaluation measure: Dentin hypersensitivity sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Hacettepe University city: Ankara zip: 06100 country: Turkey name: Abdullah Akman, PHD role: CONTACT phone: +905327609139 email: dtacakman@yahoo.com lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06271993 id: 23-233 briefTitle: SPT for Sensitization of Collagen Dressing overallStatus: RECRUITING date: 2024-02-08 date: 2024-02-16 date: 2024-03-15 date: 2024-02-22 date: 2024-02-23 name: Covalon Technologies Inc. class: INDUSTRY name: ALS Beauty and Personal Care briefSummary: The goal of this clinical trial is to determine the sensitization (contact allergy) potential of the test product ColActive Plus Collagen Matrix Dressing after a skin prick test on the skin of healthy human subjects. The main question it aims to answer is:
• Does the product induce any sensitization (contact allergy) after a skin prick using a UniTest PC (pain control) device in healthy human subjects? Participants will have the test product and both positive and negative controls applied, and skin response will be evaluated by an allergist at 15 minutes, 6 hours, and 24-48 hours post-application to see if sensitization occurs. conditions: Allergy Skin conditions: Allergic Skin Reaction studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This will be a single center, with no randomization or blinding, study design in 20 healthy adult subjects, age 18-70 years. Based on prior experience approximately 30 subjects will be enrolled to ensure 20 subjects complete the study. primaryPurpose: OTHER masking: NONE count: 30 type: ESTIMATED name: ColActivePlus Collagen Matrix Dressing measure: Wheal measurement measure: Wheal measurement measure: Wheal measurement sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ALS Beauty and Personal Care status: RECRUITING city: Torrance state: California zip: 90501 country: United States name: Ashley Glavis, BS role: CONTACT phone: 424-307-5900 email: ashley.glavis@alsglobal.com name: Jordan DeSantis, MHI, BS role: PRINCIPAL_INVESTIGATOR lat: 33.83585 lon: -118.34063 hasResults: False
nctId: NCT06271980 id: 23228/ENCORE briefTitle: Early-Onset Colorectal Cancer Recurrence acronym: ENCORE overallStatus: COMPLETED date: 2023-04-15 date: 2024-02-01 date: 2024-02-01 date: 2024-02-22 date: 2024-03-12 name: City of Hope Medical Center class: OTHER name: IRCCS San Raffaele Hospital, Milan, Italy name: Institute of Biomedical Research of Salamanca, Salamanca, Spain briefSummary: Survivors of early-onset colorectal cancer (diagnosed before age 50) may experience colorectal cancer recurrence several years after curative-intent treatments, but clinical guidelines provide unclear guidance on endoscopic surveillance.
This study aims to predict recurrence-free survival and overall survival, in survivors of early-onset colorectal cancer, using a tumor-based molecular assay based on microRNA (ribonucleic acid) conditions: Colorectal Cancer Recurrent conditions: Colorectal Cancer conditions: Colorectal Neoplasms conditions: Colorectal Adenocarcinoma conditions: Colorectal Cancer Stage I conditions: Colorectal Cancer Stage II conditions: Colorectal Cancer Stage III studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 177 type: ACTUAL name: ENCORE measure: Recurrence Free Survival measure: Overall Survival sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: City of Hope Medical Center city: Duarte state: California zip: 91010 country: United States lat: 34.13945 lon: -117.97729 hasResults: False
nctId: NCT06271954 id: 202300096A3 briefTitle: The Relationship Between Emotion Regulation and Psychiatric Disorder in Youth overallStatus: RECRUITING date: 2023-03-27 date: 2025-03-26 date: 2025-03-26 date: 2024-02-22 date: 2024-03-26 name: Chang Gung Memorial Hospital class: OTHER name: National Taiwan University Hospital briefSummary: According to the increasing worldwide prevalence rate of psychiatric disorders in youth, the mental health of youth is becoming more and more important.
Taiwan's Ministry of Health and Welfare reported the clibing suicide rate of youth in past five years and showed the prevention work and related intervention for youth's mental health was noteable. The definition of emotion regulation was "consists of the extrinsic and intrinsic processes responsible for monitoring, evaluating, and modifying emotional reactions, especially their intensive and temporal features, to accomplish one's goals." Emotion regulation strategies including "rumination", "avoidance", "suppression", "Problem-solving", "reappraisal", "acceptance", "social support", and "distraction".
Previous studies had examined the relationship between emotion regulation and mental health in youth; maladaptive emotion regulation would increase the individual's depressive and anxiety symptoms. Carstensen proposed social emotion theory in 1995 Selectivity theory (SST) refers to the need for emotion regulation, which activates Social participation in late adulthood. SST assumes that young people are more interested in social interaction behaviors related to information seeking and building self-concept. characteristics of youth affected by many normative challenges such as adolescence, school transitions, and more complex social Landscape; Adaptive emotion regulation will reduce risk of clinical emotion attacks of illness, especially depression and anxiety.To explore the relationship between emotion regulation and mental health from a psychosocial developmental aspect, we focused on the interaction between individual and environment. Compared with the previous generation, most youths of this generation were participating in social activities and building up interpersonal relationships through the internet, suggesting the internet was an important social context. conditions: Major Depressive Disorder conditions: Anxiety Disorder conditions: Attention Deficit Hyperactivity Disorder (ADHD) conditions: Adjustment Disorder studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 200 type: ESTIMATED measure: The Difference and Similarity in Emotional Regulation Strategy Patterns between Western and Eastern Countries. sex: ALL minimumAge: 15 Years maximumAge: 24 Years stdAges: CHILD stdAges: ADULT facility: Chang-Geng Medical Foundation Chang-Geng Memorial Hospital status: RECRUITING city: Keelung zip: 204 country: Taiwan name: Tzuyu Liu role: CONTACT phone: (02)24329292 phoneExt: 2720 email: tzuyu35@cgmh.org.tw lat: 25.12825 lon: 121.7419 hasResults: False
nctId: NCT06271941 id: HAPC-RCT briefTitle: Prophylactic Double Thermal Ablation and Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps: A Randomized Controlled Trial overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-10-01 date: 2028-04-01 date: 2024-02-22 date: 2024-02-22 name: Centre hospitalier de l'Université de Montréal (CHUM) class: OTHER briefSummary: Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. Recent studies have found that the use of hybrid argon plasma coagulation (h-APC) for the ablation of the margin and base of resection post-EMR could significantly reduce the recurrence rate, and complete closure of the post-EMR defect can prevent other adverse pre- and post-procedure outcomes such as bleeding.
We hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation post-EMR for large (≥20mm) colorectal LSLs will demonstrate a lower recurrence rate compared to Snare Tip Soft Coagulation (STSC) margin ablation. We also hypothesize that performing complete closure of the EMR defect will result in lower rates of adverse events compared to cases where no defect closure is performed. conditions: Colorectal Cancer conditions: Polyp of Colon studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 892 type: ESTIMATED name: Hybrid Argon Plasma Coagulation (h-APC) name: Snare tip soft coagulation (STSC) measure: To compare the recurrence rates after EMR colorectal between the h-APC and SSTC methods measure: To assess the potential advantages associated with a complete defect closure sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre Hospitalier de l'Université de Montréal city: Montréal state: Quebec country: Canada lat: 45.50884 lon: -73.58781 hasResults: False
nctId: NCT06271928 id: TJ-IRB20220634-yijingkeli briefTitle: A Multicenter Clinical Study of Yijing Keli in the Treatment of Ovarian Aging overallStatus: RECRUITING date: 2021-10-01 date: 2024-01-01 date: 2025-01-01 date: 2024-02-22 date: 2024-02-22 name: Tongji Hospital class: OTHER briefSummary: Ovarian aging (OA) seriously affects the physical and mental health of women. Nowadays, Chinese herbs have huge appeal and potential in treating OA. We have created a new Chinese herbal combination Yijing Keli, whereas its safety and efficacy still need to be validated. Hence, we will perform a population-based, multicenter study to confirm the safety and efficacy of Yijing Keli in therapy of OA. We aim to provide a solid evidence for TCM in therapy of OA. conditions: Ovarian Aging studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Yijing Keli measure: the recovery rate of ovarian function sex: FEMALE minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology status: RECRUITING city: Wuhan country: China name: jinjin zhang, professor role: CONTACT phone: +8683663078 email: jinjinzhang@tjh.tjmu.edu.cn name: yan zhang, MD role: CONTACT phone: +8683663078 lat: 30.58333 lon: 114.26667 hasResults: False
nctId: NCT06271915 id: cervical spine mobilization briefTitle: Role of Cervical Spine Mobilization on Lateral Epicondylitis overallStatus: RECRUITING date: 2024-02-15 date: 2024-05-15 date: 2024-06-15 date: 2024-02-22 date: 2024-03-05 name: Cairo University class: OTHER briefSummary: The study's primary goal is to examine the effectiveness of Mulligan's technique in reducing hyperalgesia in lateral epicondylitis, focusing on cervical spine, while also investigating its influence on central sensitization in relation to lateral epicondylitis. conditions: Lateral Epicondylitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: SNAGs - eccentric exercise measure: Leeds assessment of neuropathic symptoms and sign (LANSS) scale measure: Pain-free hand grip test measure: The Numeric Rating Scale (NRS) sex: ALL minimumAge: 30 Years maximumAge: 50 Years stdAges: ADULT facility: Outpatient physical therapy, Faculty of physical therapy status: RECRUITING city: Giza zip: 2334 country: Egypt name: Ahmed ElMelhat role: CONTACT phone: 01112595022 email: ahmed.elmelhat@cu.edu.eg lat: 30.00808 lon: 31.21093 hasResults: False
nctId: NCT06271902 id: IRB-2023-531 briefTitle: Effects of the Singapore Youth Shoulder Overuse Injury Prevention Program Among Youth Volleyball Athletes in Singapore overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-06 date: 2024-06 date: 2024-02-22 date: 2024-02-22 name: Nanyang Technological University class: OTHER briefSummary: The Singapore Youth Shoulder Overuse Injury Prevention Program (YoSO-IPP) includes an exercise segment and an education segment. This study will (1) assess the effects of the exercise segment, and (2) assess the effects of the education segment among youth volleyball athletes using a randomized controlled trial over 12 weeks. Performance outcome measures of shoulder eccentric external rotation strength, shoulder internal rotation range of motion, and thoracic rotation range of motion will be used to assess the effects of the exercise segment. Knowledge scores via an online questionnaire will be used to assess the effects of the education segment.
Hypothesis: The YoSO-IPP will have an effect on shoulder eccentric external rotation strength, shoulder internal rotation range of motion, and thoracic rotation range of motion and on knowledge scores. conditions: Sport Injury studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a randomized controlled trial with an intervention group and a control group to evaluate the effects of the YoSO-IPP. The intervention group will perform the exercises and attend the online educational workshop. The control group will only perform lower body stretching exercises which is considered as a sham program. primaryPurpose: PREVENTION masking: NONE count: 50 type: ESTIMATED name: Singapore Youth Shoulder Overuse Injury Prevention Program name: Lower body stretching program measure: Shoulder external rotation strength measure: Internal rotation range of motion measure: Thoracic rotation range of motion measure: Knowledge of overuse injuries measure: Shoulder overuse injury prevalence measure: Elbow overuse injury prevalence measure: Shoulder overuse injury severity measure: Elbow overuse injury severity sex: ALL minimumAge: 12 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Nanyang Technological University city: Singapore country: Singapore lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06271889 id: B.10.1.TKH.4.34.H.GP.0.01/330 briefTitle: The Effect of Electro-fetal monıtorısıon Sound on Anxiety, paın and Postpartum Bonding at the First Phase of Delivery overallStatus: RECRUITING date: 2021-11-24 date: 2024-02-24 date: 2024-11-20 date: 2024-02-22 date: 2024-02-22 name: Saglik Bilimleri Universitesi class: OTHER briefSummary: University of Health Sciences, Istanbul Umraniye training and Research Hospital, Clinic of Obstetrics and gynecology, birth, maternity and Child Health Hospital, Aydın to the clinic, pregnant women, pregnant women in active labor act, and received acceptance to delivery to the fetal heart sound by existing tripped; fetal heart sounds of pregnant women, anxiety, pain and the birth in order to determine the effect of connecting the end of the level will be conducted. The study will guide midwives in reducing the anxiety or pain of pregnant women. conditions: Delivery Fear conditions: Labor Pain conditions: Maternal-Fetal Relations studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized parallel controlled experimental design primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: Which of the participants is the control or intervention group will be selected by randomization. whoMasked: PARTICIPANT count: 128 type: ESTIMATED name: Non-stress test measure: VİSUAL ANALOG SCALE measure: STATUS AND CONTINUOUS ANXIETY SCALE measure: Postpartum Attachment Scale (PASAS): sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Saglık Bilimleri Universitesi status: RECRUITING city: Istanbul country: Turkey name: YASEMİN AYDIN KARTAL role: CONTACT phone: +90 5432870029 email: yasemin.aydin@sbu.edu.tr lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06271876 id: 0011 briefTitle: Influence of an Inspiratory Muscle Fatigue Protocol on Healthy Youngs on Respiratory Muscle Strength, Vertical Jump Performance and Muscle Oxygen Saturation overallStatus: NOT_YET_RECRUITING date: 2024-03-03 date: 2024-03-09 date: 2024-03-19 date: 2024-02-22 date: 2024-02-22 name: Sierra Varona SL class: OTHER name: Universidad Europea de Madrid briefSummary: Respiratory muscle training represents an effective method increasingly utilized in both sports and healthcare domains, employing various devices, among which threshold devices are prominent. The aim of this study is to determine the relationship between inspiratory muscle fatigue and muscular strength in lower limbs, in both healthy and pathological subjects, as well as the association between such fatigue and other variables, including maximal inspiratory pressure and muscle tissue oxygen levels.
Measurements of variables, such as maximal inspiratory pressure, peripheral muscle tissue oxygen levels, diaphragmatic strength (ultrasound image) and vertical jump performance, will be conducted. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: the outcome assessor will not know in which group is each participant, and the investigator will receive the data without knowing which data is from which group whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 18 type: ESTIMATED name: Inspiratory muscle training measure: Respiratory muscle strength measure: Diaphragmatic thickness and thickening fraction measure: Diaphragm movement curve measure: Vertical jump performance sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT hasResults: False