hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06379620 id: 22-5544 briefTitle: Pilot Open Label Use of the Hi-OXSR for the Treatment of Post COVID-19 Cognitive Dysfunction acronym: Hi-OXSR overallStatus: COMPLETED date: 2022-11-29 date: 2024-03-04 date: 2024-03-04 date: 2024-04-23 date: 2024-04-25 name: University Health Network, Toronto class: OTHER briefSummary: During the worldwide COVID-19 pandemic a large number patients reported different functional complaints one month or later after recovery from the acute infection. This entity had a number of names including "long-COVID" or "post COVID condition". Long-COVID is on the rise and no effective treatment exists yet to improve cognitive function. Recent research has shown that people with even mild COVID had a greater decline in executive function, notably in their ability to perform complex tasks. What drives post-COVID cognitive changes is still a mystery and there are no effective treatments available. One hypothesis is that there is persistent immune activation resulting in reduction in cerebral blood flow. There is evidence that increased CO2 may decrease inflammation, and decreased CO2 may increase inflammation.
Objectives: The primary objective of this pilot study is to assess the safety and tolerability of the use of Hi-OX sequential rebreathing for the treatment of post-COVID cognitive dysfunction. The secondary objective is to identify the effects of the use of the Hi-OX rebreathing treatment in changing post-COVID cognitive dysfunction. conditions: Post COVID-19 Condition studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This is an open label, pilot treatment study. Screening data will be reviewed to determine subject eligibility. Upon successful completion of all screening procedures, subject will be considered eligible for enrollment.
The subject will self-administer oxygen gas at 1to 3LPM via a Hi-OxSR Sequential Rebreathing mask, twice a day for 30 minutes with ventilation supplemented by the subject's rebreathed exhaled air. Total treatment is for 14 days. Subjects will be asked to return to the clinic for additional evaluations on Days 15 and 45. primaryPurpose: TREATMENT masking: NONE count: 37 type: ACTUAL name: Hi-OxSR Sequential Rebreathing mask (oxygen concentrator) measure: Safety of use of Hi-OX sequential rebreathing device sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Health Network city: Toronto state: Ontario zip: M5G 2C4 country: Canada lat: 43.70011 lon: -79.4163 hasResults: False
nctId: NCT06379607 id: HFNC2024 briefTitle: High Flow Nasal Cannula Rates in Pediatric Asthma overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2025-09-30 date: 2025-09-30 date: 2024-04-23 date: 2024-04-23 name: University of Rochester class: OTHER briefSummary: This is a randomized, open-label, 3-armed feasibility trial will examine conventional oxygen therapy (COT) vs high flow nasal cannula at 4L/min flow vs HFNC at 2L/kg/min flow (max 60L/min) in moderate to severe pediatric asthma exacerbations. conditions: Pediatric Asthma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 27 type: ESTIMATED name: "High Flow" High Flow Nasal Cannula name: "Low Flow" High Flow Nasal Cannula measure: Percent of participants enrolled measure: Mean Change in Pediatric Asthma Severity Score (PASS) measure: Mean Change in Respiratory Rate measure: Mean Total Duration of Continuous Albuterol measure: Percentage of Children with Escalation of Respiratory Support measure: Mean Total Duration of Respiratory Support measure: Percentage of Participants placed on Adjunct Asthma Therapies measure: Percentage of Participants who needed Sedation measure: Percentage of Participants on Antibiotics measure: Mean PICU Length of Stay (LOS) measure: Mean Hospital Length of Stay (LOS) sex: ALL minimumAge: 3 Years maximumAge: 17 Years stdAges: CHILD hasResults: False
nctId: NCT06379581 id: 2022-04900-02 briefTitle: Skin Cancer Diagnostics Using Photoacoustic Imaging overallStatus: RECRUITING date: 2023-01-01 date: 2025-10-01 date: 2025-10-01 date: 2024-04-23 date: 2024-04-24 name: Region Skane class: OTHER name: Lund University briefSummary: In this clinical study, photoacoustic imaging will be used on patients with suspected skin cancer (primarily melanoma, basal cell carcinoma, and squamous cell carcinoma) to determine the tumor borders both superficially and at a depth. conditions: Skin Cancer studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: Tumor thickness measure: Tumor size sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Ophthamology, Lund, Skåne University Hospital status: RECRUITING city: Lund zip: 22185 country: Sweden name: Malin Malmsjö, Professor role: CONTACT phone: +46722335060 email: malin.malmsjo@med.lu.se lat: 55.70584 lon: 13.19321 hasResults: False
nctId: NCT06379568 id: SichuanPPHLC01 briefTitle: Risk of Aspergillus Infection in Patients With Chronic Lung Disease overallStatus: COMPLETED date: 2022-07-01 date: 2024-01-31 date: 2024-01-31 date: 2024-04-23 date: 2024-04-23 name: Lin Chen class: OTHER briefSummary: Large doses of systemic corticosteroids ，severe lung tissue damage and longer COPD diagnosis may increase the risk of IPA in patients with chronic structural lung disease. By comparing the risk factors of aspergillus colonization group and aspergillus infection group, the main risk factors of aspergillus pneumonia were determined. conditions: Fungal Infection Lungs studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 209 type: ACTUAL name: No intervention measure: Descriptive statistical index measure: Independent risk factor for aspergillus pneumonia measure: The area under ROC curve of risk factors for aspergillus pneumonia measure: Threshold analysis of aspergillus pneumonia sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sichuan Provincial People's Hospital city: Chengdu state: Sichuan zip: 610072 country: China lat: 30.66667 lon: 104.06667 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2024-01-31 uploadDate: 2024-04-17T04:01 filename: Prot_SAP_000.pdf size: 101446 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-01-31 uploadDate: 2024-04-14T12:03 filename: ICF_001.pdf size: 105933 hasResults: False
nctId: NCT06379555 id: 2023-A02756-39 briefTitle: Wrist Fractures Management With Arthroscopic Assistance Under Walant - Exploratory Study acronym: WALANPOIGNE overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-01 date: 2026-01 date: 2024-04-23 date: 2024-04-23 name: GCS Ramsay Santé pour l'Enseignement et la Recherche class: OTHER briefSummary: Wrist articular fractures are more difficult to treat and rehabilitation takes longer. Furthermore, these joint fractures are frequently accompanied by ligament lesions of the carpal bones.
In this context, this study is based on the hypothesis that it is possible to combine arthroscopy and the WALANT anesthesia technique for reducing wrist fractures conditions: Wrist Fractures studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: Walanpoigne measure: Failure percentage measure: Pain assessment measure: Patient experience measure: Wrist mobility measure: Functional characteristics of the wrist measure: Functional characteristics of the wrist measure: Complications sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06379529 id: USCOPD2022B briefTitle: The COPD CARE Study: Evaluating the Impact of a Virtual-First COPD Service on Major Cardiac and Respiratory Events overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-09 date: 2025-12 date: 2024-04-23 date: 2024-04-23 name: NuvoAir Medical PC class: INDUSTRY name: Optum, Inc. briefSummary: A 12 month interventional study of up to 1,050 people with COPD to determine if the NuvoAir virtual-first clinical service leads to fewer moderate and severe COPD exacerbations and cardiac events, reduces healthcare utilization, and lowers the total cost of care compared to a control cohort that receives standard care only. conditions: COPD Exacerbation conditions: COPD conditions: Cardio/Pulm: Heart Failure studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Pragmatic evaluation of a clinical service using a prospective cohort comparison of intervention vs propensity matched controls. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 1050 type: ESTIMATED name: NuvoAir clinical service measure: Moderate & Severe Exacerbations measure: Severe COPD Exacerbations measure: Major Adverse Cardiac Event measure: 30-Day COPD Related Readmissions measure: All-Cause Hospitalizations measure: All-Cause Readmissions measure: Days Hospitalized due to COPD measure: Cost of Care Related to COPD measure: Medication Adherence measure: Quality of Life (QOL) measure: Short-Acting Beta-Agonists Used measure: Courses of Oral Antibiotics/Steroids measure: Self-efficacy measure: Patient Activation measure: Cat Score measure: mMRC Dyspnea Scale measure: Physical Activity sex: ALL minimumAge: 30 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06379516 id: NB240004-NB-V briefTitle: Process Validation in Dermatology: Assessing Wound Creation Methods and Treatment Efficacy overallStatus: COMPLETED date: 2024-01-17 date: 2024-01-26 date: 2024-02-16 date: 2024-04-23 date: 2024-04-23 name: NovoBliss Research Pvt Ltd class: OTHER briefSummary: The primary objective of this study is to validate controlled methods of wound, including 1%w/v SLS, 3%w/v SLS, and 24-24 times tape stripping, on the forearms of subjects.
The study aims to standardize the procedures for creating wounds and systematically evaluate the effects of these methods on various skin parameters. conditions: Validation of the Process of Wound Creation and Evaluation studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Proof of science/concept primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 5 type: ACTUAL name: Moisturising Cream (5%) name: Moisturising Cream (10%) name: Coconut Oil measure: Trans Epidermal Water Loss (TEWL) measure: Skin hydration measure: Skin surface topography measure: Dermatological Assessment sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: NovoBliss Research Pvt Ltd city: Gandhinagar state: Gujarat zip: 382421 country: India lat: 23.21667 lon: 72.68333 hasResults: False
nctId: NCT06379503 id: 2021/37-04 briefTitle: Effect of Heart Yoga Applıed To Patıents Undergoıng Cardıovascular Surgery on Sleep, Depressıon And Qualıty of Lıfe overallStatus: COMPLETED date: 2021-12-15 date: 2023-01-18 date: 2023-06-18 date: 2024-04-23 date: 2024-04-23 name: Dokuz Eylul University class: OTHER briefSummary: This type of study is a randomized controlled trial. The aim is to contribute to the literature by comparing the effects of heart yoga on the depression level, sleep and quality of life of patients who do and do not do heart yoga.
Researchers will compare intervention and control groups to see if there are any effects on sleep quality, depression level, and quality of life. conditions: Cardiac Disease conditions: Yoga conditions: Nursing Caries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: randomized controlled trial primaryPurpose: SUPPORTIVE_CARE masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ACTUAL name: HEART YOGA name: routine nursing care measure: sleep quality measure: depression measure: life quality sex: ALL minimumAge: 45 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Dokuz Eylül Üniversitesi Hastanesi city: İ̇zmi̇r state: Balçova zip: 35330 country: Turkey lat: 38.41273 lon: 27.13838 hasResults: False
nctId: NCT06379490 id: CTA no: 2024-510572-20-00 id: 2024-510572-20-00 type: CTIS id: P-2023-296 type: OTHER domain: Privacy - Region Hovedstaden briefTitle: Ultrasound-guided Infraclavicular Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures overallStatus: RECRUITING date: 2024-04-23 date: 2024-08-01 date: 2025-09-01 date: 2024-04-23 date: 2024-04-24 name: Nordsjaellands Hospital class: OTHER briefSummary: To investigate the feasibility of the lateral infraclavicular plexus brachialis (LIC) block for acute closed reduction of distal radius fractures, the investigators will compare the pain-relieving and muscle-relaxing properties of the LIC block with short- and long-acting local anesthetics in different concentrations but at the same volume. In addition to motor and sensory blockade during repositioning, feasibility will also be assessed by other patient-related and block-related factors, as well as by factors related to the repositioning and plastering procedure. conditions: Distal Radius Fractures conditions: Lidocaine conditions: Ropivacaine conditions: Fracture Dislocation conditions: Closed Reduction of Fracture and Application of Plaster Cast conditions: Colles' Fracture studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 63 type: ESTIMATED name: Ropivacaine 0.2% Injectable Solution name: Lidocaine epinephrine name: Ropivacaine 0.5% Injectable Solution measure: Block success measure: Degree of sensory and motor blockade measure: Total duration of sensory blockade measure: Total duration of motor blockade measure: Pain intensity before block performance measure: Time to pain relief/lowest pain intensity measure: Pain intensity during closed reduction measure: Pain intensity during cast application measure: Time to pain breakthrough after the blockade has ended measure: Maximum pain intensity after the blockade has ended measure: Duration of maximum pain intensity after the blockade has ended measure: Amount of strong painkillers consumed by patients within 24 hours after closed reduction measure: Grading of closed reduction difficulty measure: Quality of closed reduction evaluated by X-ray imaging measure: Attempts used for closed reduction measure: Grading of casting difficulty measure: The patient's experience of the treatment measure: Occurence of adverse events (AE) and serious adverse events (SAE) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Copenhagen University Hospital - North Zealand status: RECRUITING city: Hillerød zip: 3400 country: Denmark name: Anders K. Nørskov, PhD role: CONTACT phone: 48 29 74 59 phoneExt: +45 email: anders.kehlet.noerskov@regionh.dk name: Kai H. W. Lange, DMSc role: CONTACT phone: 48 29 42 52 phoneExt: +45 email: kai.henrik.wiborg.lange@regionh.dk lat: 55.92791 lon: 12.30081 hasResults: False
nctId: NCT06379477 id: refractive error surprises briefTitle: Correction of Refractive Error Surprises After Cataract Surgery in Adults overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-05-31 date: 2025-06-30 date: 2024-04-23 date: 2024-04-23 name: Assiut University class: OTHER briefSummary: A refractive surprise can be defined as the failure to achieve the intended postoperative refractive target or the presentation of unexpected and, unwanted post-operative refractive error. It can cause anisometropia or dominance switch and is a source of patient dissatisfaction due to unmet expectations.The best way to manage refractive surprise is to prevent it. The 2017 NICE guidelines on the management of cataracts provide advice on prevention of refractive surprise through accurate biometry, A-constant optimisation, intraocular lens (IOL) formula selection and avoiding wrong lens implant errors.Benchmark standards for NHS cataract surgery dictate that 85% of eyes should be within 1 dioptre (D) and 55% within 0.5D of target spherical equivalent refraction following surgery. conditions: Refractive Errors studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 63 type: ESTIMATED name: Refractive surgeries measure: Diagnosis and treatment of the resulting refractive error surprises sex: ALL minimumAge: 55 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06379464 id: CALM2303 briefTitle: Screening of New Markers of Gut Microbiota in Stroke and Depression: a Cross-sectional Study overallStatus: RECRUITING date: 2023-09-01 date: 2024-06-30 date: 2024-12-30 date: 2024-04-23 date: 2024-04-23 name: Zhujiang Hospital class: OTHER briefSummary: Objectives of Study： Through the cross-sectional study of stroke and depression, key biomarkers are targeted by screening disease-associated intestinal bacteria, metabolites and immune factors through multi-omics techniques. conditions: Acute Ischaemic Stroke conditions: Depression studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 320 type: ESTIMATED measure: The severity of neurological damage in stroke patients measure: The functional recovery outcomes after stroke measure: The severity of symptoms in patients with depression sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Zhujiang Hospital of Southern Medical University status: RECRUITING city: Guanzhou state: Guangdong zip: 510145 country: China name: Hongwei Zhou, Professor role: CONTACT phone: 186 8848 9622 email: hzhou@smu.edu.cn hasResults: False
nctId: NCT06379451 id: [2023]YLJSA088 briefTitle: An Clinical Study of NKG2D-CAR-NK Cells for the Treatment of Refractory Recurrent Multiple Myeloma overallStatus: NOT_YET_RECRUITING date: 2024-04-18 date: 2025-12-31 date: 2025-12-31 date: 2024-04-23 date: 2024-04-23 name: Changzhou No.2 People's Hospital class: OTHER briefSummary: Multiple myeloma (MM) is a malignant disease characterized by the abnormal proliferation of clonal plasma cells. However, multiple myeloma remains an incurable disease and requires the exploration of more effective treatment methods to improve the efficacy of relapsed refractory multiple myeloma and prolong survival time.Currently, clinical application of CAR-T is mostly based on autologous T cell preparation, while relapsed/refractory AML patients have undergone multiple chemotherapy treatments, resulting in impaired self-T cell function, which affects the efficacy and prognosis of CAR-T therapy. Therefore, it is necessary to find new alternative treatments. NK cells are important immune cells in the body and are an important component of innate immunity. Compared with CAR-T cell therapy, CAR-NK cells have unique advantages in adoptive cell therapy. NKG2D receptor is an activating receptor expressed on NK cells, which can recognize NKG2D ligands (NKG2DL) expressed on tumor cells, activating NK cell killing activity through NKG2D-NKG2DL interaction. Therefore, the investigators plan to treat relapsed multiple myeloma by infusing NKG2D-CAR-NK cells to evaluate its efficacy and safety. conditions: Multiple Myeloma studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 9 type: ESTIMATED name: NKG2D Chimeric Antigen Receptor NK Cell Injection measure: Incidence of Dose Limiting Toxicity (DLTs) measure: Treatment Emergent Adverse Events (TEAEs) measure: Objective Response Rate of subjects sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Changzhou Second People's Hospital city: Changzhou state: Jiangsu zip: 213000 country: China name: Wei Qin, doctor role: CONTACT phone: +8618796912763 email: qinwei19840601@163.com lat: 31.77359 lon: 119.95401 hasResults: False
nctId: NCT06379438 id: 06/16022018 briefTitle: Treatment of Aphtous Ulcers With Photodynamic Therapy overallStatus: COMPLETED date: 2018-03-05 date: 2019-03-01 date: 2019-03-08 date: 2024-04-23 date: 2024-04-23 name: Yuzuncu Yıl University class: OTHER briefSummary: The search for methods that can shorten the treatment process of aphthous ulcers, the etiology of which is not fully understood, continues. The aim of this study was to determine whether photodynamic therapy (PDT) is a clinically effective alternative in the treatment of oral aphthous ulcers. conditions: Oral Ulcer conditions: Aphthous Recurrent Ulcers studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 30 type: ACTUAL name: Photodynamic therapy (indocyanine green+laser) measure: Ulcer wound healing with diameter measurement measure: Level of recovery measure: Pain evaluation with Visual Analogue Scale sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Yuzuncu Yil University city: Van state: Merkez zip: 65080 country: Turkey lat: 38.49457 lon: 43.38323 hasResults: False
nctId: NCT06379425 id: 23-0050 briefTitle: Impact of Preoperative Opioid-free Multimodal Analgesia on Time to Trial of Void in Ambulatory Urogynecologic Surgeries overallStatus: RECRUITING date: 2024-03-01 date: 2026-03-01 date: 2026-03-01 date: 2024-04-23 date: 2024-04-23 name: Northwell Health class: OTHER briefSummary: This is a double-arm randomized control trial evaluating the impact of preoperative opioid-free analgesia on time to trial of void in ambulatory urogynecologic surgeries. The investigators hypothesize that receipt of acetaminophen, celecoxib and gabapentin preoperatively versus acetaminophen alone will reduce the time to trial of void in patients undergoing same-day minor urogynecologic procedures. conditions: Pain, Postoperative conditions: Postoperative Pain, Acute studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: PREVENTION masking: NONE count: 70 type: ESTIMATED name: Acetaminophen name: Celecoxib name: Gabapentin measure: Time to initiation of active trial of void sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Northwell Health South Shore Surgery Center status: RECRUITING city: Bay Shore state: New York zip: 11706 country: United States name: Kathleen R Catalano, MSN, RN-BC role: CONTACT phone: 631-647-5550 email: kcatalano@southshoresurg.com name: Nirmala Pillalamarri, MD role: PRINCIPAL_INVESTIGATOR name: Steliana Fakas, MD role: SUB_INVESTIGATOR lat: 40.7251 lon: -73.24539 hasResults: False