hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06362681 id: CF-2023-I-13 briefTitle: Effects of Different Remineralization Agents on Molar Incisor Hypomineralization Defects: a Randomized Clinical Study overallStatus: RECRUITING date: 2024-03-01 date: 2024-06-30 date: 2026-03-30 date: 2024-04-12 date: 2024-04-12 name: Universidad Nacional Autonoma de Mexico class: OTHER briefSummary: The aim of this study was to present a comparative evaluation of the long-term efficacy of fluoride varnish( Flúor protector), Clinpro™ White Varnish and pastes containing CPP-ACP in the remineralization of creamy-white and yellow brown defects in incisors and permanent first molars with Molar Incisor Hypomineralization (MIH) in schoolchildren 6-12 years-old in Mexico. conditions: Molar Incisor Hypomineralization studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescription: The children will be randomly divided into the experiment groups: control (oral hygiene motivation only), fluoride varnish, clinpro white Varnish and pastes containing CPP-ACP and followed up for 24 months. primaryPurpose: PREVENTION masking: QUADRUPLE maskingDescription: using a block randomization technique in which a computer-generated sequence would be used to assign each participant to a particular group in the allocation ratio of 1:1. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Fluoride measure: Mineral Density sex: ALL minimumAge: 6 Years maximumAge: 12 Years stdAges: CHILD facility: Alvaro Garcia Pérez status: RECRUITING city: San Pedro Apatlaco state: Morelos country: Mexico lat: 18.79306 lon: -98.95972 hasResults: False
nctId: NCT06362668 id: RCV-0006-EU briefTitle: EU Sites: Fluid Management of Acute Decompensated Heart Failure With Reprieve Decongestion Management System (FASTR-EU) acronym: FASTR-EU overallStatus: NOT_YET_RECRUITING date: 2024-04-09 date: 2024-10-01 date: 2024-12-31 date: 2024-04-12 date: 2024-04-12 name: Reprieve Cardiovascular, Inc class: INDUSTRY briefSummary: The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve DMS system to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute decompensated heart failure (ADHF). The main objective is to determine if the Reprieve DMS is non-inferior to state-of-the-art urine sodium guided aggressive diuretic titration in two European HF centers of excellence. conditions: Acute Decompensated Heart Failure studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Reprieve Decongestion Management System name: Diuretic (furosemide, bumetanide, torsemide, hydrochlorothiazide, and/or acetazolamide) measure: Total sodium loss (in mmol of sodium) per 24 hours measure: Comparison of occurrence of composite endpoint comprised of clinically significant acute kidney injury, severe electrolyte abnormality, or symptomatic hypotension or hypertensive emergency. measure: Total net fluid volume loss (difference between urine output volume and fluid input volume) per 24 hours measure: Weight loss per 24 hours at end of randomized therapy measure: Time on IV loop diuretic measure: Number of participants with ≥ 0.3 mg/dL increase in serum creatinine sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Medical Center Groningen city: Groningen country: Netherlands name: Kevin Damman, MD role: CONTACT lat: 53.21917 lon: 6.56667 facility: Wroclaw Medical University city: Wrocław country: Poland name: Jan Biegus, MD role: CONTACT lat: 51.1 lon: 17.03333 hasResults: False
nctId: NCT06362655 id: ANID/FONDECYT 2013/1230801 briefTitle: ACTIBESE Project - Active Behaviour in School Education acronym: ACTIBESE overallStatus: ENROLLING_BY_INVITATION date: 2023-04-01 date: 2023-12-31 date: 2025-12-31 date: 2024-04-12 date: 2024-04-12 name: Pontificia Universidad Catolica de Valparaiso class: OTHER name: Universidad de La Frontera briefSummary: The ACtive BEhaviour in School Education (ACTIBESE) project aims to assess and intervene in Chilean schoolchildren's active behaviours by examining the influence of personal, interpersonal, and school factors. This study includes a cross-sectional and intervention study involving 152 schools in the Valparaíso and Araucanía Regions, representing urban and rural areas. Participants, divided into children (8-11 years old) and adolescents (12-17 years old), will undergo a comprehensive evaluation, including sociodemographic characteristics, physical activity (PA) levels, parental and peer support, teaching styles of the teachers, and school environment characteristics.
The research will use mixed models, ANCOVA (Analysis of Covariance) , and logistic regressions for data analysis, incorporating multilevel logistic regressions to account for school-level dependencies. The study's outcomes will contribute valuable insights into the complex interactions between school, interpersonal, and personal factors influencing schoolchildren's PA, aiding the development of targeted interventions. This comprehensive approach aligns with the project's goal of fostering a physically active lifestyle among Chilean schoolchildren. conditions: Physical Inactivity conditions: Child Behavior conditions: Family Support studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Intervention Study primaryPurpose: BASIC_SCIENCE masking: NONE maskingDescription: No apply count: 144 type: ESTIMATED name: Intervention measure: Physical activity levels sex: ALL minimumAge: 9 Years maximumAge: 17 Years stdAges: CHILD facility: IRyS Group, School of Physical Education, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile. city: Viña Del Mar state: Valparaiso zip: 2300000 country: Chile lat: -33.02457 lon: -71.55183 hasResults: False
nctId: NCT06362629 id: WCH240407 briefTitle: AI App for Management of Atopic Dermatitis overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2028-12-31 date: 2029-08-31 date: 2024-04-12 date: 2024-04-12 name: West China Hospital class: OTHER briefSummary: Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by recurrent rashes and itching, which seriously affects the quality of life of patients and brings heavy economic burden to society. The Treat to Target (T2T) strategy was proposed to guide optimal use of systemic therapies in patients with moderate to severe AD, and it is emphasized patients' adherence and combined evaluation from both health providers and patients. While effective treatments for AD are available, non-adherence of treatment is common in clinical practice due to the patients' unawareness of self-evaluation and lack of concern about the specific follow-up time points in clinics, which leads to the treatment failure and repeated relapse of AD.
We aim to develop an AIADMS in the form of smartphone app to integrate T2T approach for both clinicians and patients, and design clinical trials to verify the effectiveness and safety of the app. Methods: This project consists of three parts, AI training model for diagnosis and severity grading of AD based on deep learning, development of Artificial Intelligence assistant decision-making system (AIADMS) in the form of app, and design of a randomized controlled trial to verify the effectiveness and safety of AIADMS App for improvement of the clinical outcomes in AD patients.
Impact: This is the first AIADMS based app for AD management running through thediagnosis, patients' self-participation, medical follow-up, and evaluation of achievement of goal of T2T. conditions: Atopic Dermatitis conditions: Artificial Intelligence studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 232 type: ESTIMATED name: Artificial Intelligence assistant decision-making system (AIADMS) App measure: The overall efficiency rate of treating objectives including PP-NRS, EASI, SCORAD, POEM, and DLQI at 12 weeks after treatment measure: The seperated efficiency rate of treating objectives including PP-NRS, EASI, SCORAD, POEM, and DLQI measure: The economic consumption measure: Satisfaction evaluation sex: ALL minimumAge: 1 Year maximumAge: 75 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362616 id: N23PBD briefTitle: Preoperative Accelerated Partial Breast Irradiation in Patients With Locally Recurrent or Second Primary Breast Cancer acronym: PAPBI-3 overallStatus: RECRUITING date: 2024-04-12 date: 2026-10-11 date: 2027-04-11 date: 2024-04-12 date: 2024-04-18 name: The Netherlands Cancer Institute class: OTHER briefSummary: This study evaluates the acute toxicity and feasibility of repeat breast conserving therapy with preoperative accelerated partial breast re-irradiation (PAPBI) in female patients aged 51 years or older with ipsilateral recurrent or second primary low-risk breast cancer. conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 31 type: ESTIMATED name: Preoperative accelerated partial breast irradiation name: Breast conserving surgery name: Sentinel node procedure name: Biopsy track removal measure: Acute post-treatment toxicity measure: Fibrosis/induration measure: Patient-reported Outcome Measures (PROMS): EORTC Quality of Life Questionnaire (QLQ)-C30 measure: Patient-reported Outcome Measures (PROMS): EORTC QLQ-BR23 measure: Patient-reported Outcome Measures (PROMS): Patient's Questionnaire Cosmesis measure: Cosmetic outcome according to the BCCT.core software program sex: FEMALE minimumAge: 51 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Netherlands Cancer Institute status: RECRUITING city: Amsterdam zip: 1066CX country: Netherlands name: Astrid Scholten, MD PhD role: CONTACT phone: +31205129111 email: a.scholten@nki.nl lat: 52.37403 lon: 4.88969 hasResults: False
nctId: NCT06362590 id: LV-SPIND-001 briefTitle: Expanded Access Use of Ladiratuzumab Vedotin in Advanced Solid Tumors overallStatus: AVAILABLE date: 2024-04-12 date: 2024-04-12 name: Seagen Inc. class: INDUSTRY briefSummary: The purpose of this study is to provide the option of Ladiratuzumab Vedotin treatment to eligible patients in studies SGNLVA-005. studyType: EXPANDED_ACCESS name: ladiratuzumab vedotin stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362577 id: TSC202202 briefTitle: Clinical Study of HIFU for Localized Prostate Cancer acronym: HIFU overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-11-30 date: 2026-12-31 date: 2024-04-12 date: 2024-04-12 name: RenJi Hospital class: OTHER briefSummary: In this study, the safety and effectiveness data of Sonablate system, a transrectal high-intensity focused ultrasound therapeutic instrument, in the treatment of localized prostate cancer were collected, and the treatment conditions of patients with other methods (such as radical prostatectomy) were compared and analyzed. Observe the differences in treatment effect, survival rate, postoperative PSA, recurrence and complications.
To analyze and compare the clinical outcome, postoperative complications and tumor control of HIFU and robot-assisted laparoscopic radical prostatectomy for localized prostate cancer, and to explore the effectiveness and safety of HIFU in the treatment of localized prostate cancer, so as to provide an alternative treatment for localized prostate cancer. conditions: Localized Prostate Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 100 type: ESTIMATED name: EQ-5D-5L IPSS IIEF-5 EPIC-26 ECOG measure: Incidence of postoperative complications measure: The time to reach the lowest point of PSA measure: Assessment of quality of life and sexual function spontaneously reported at 2, 6, and 12 months after surgery measure: The negative rate of tumor exclusion was evaluated by imaging (mainly mp-MRI) at 2 and 12 months after surgery measure: The incidence of biochemical recurrence that requires remedial or systemic treatment 12 months after surgery measure: Postoperative overall survival rate sex: MALE minimumAge: 40 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06362551 id: INC-GS-2024-002 briefTitle: Oocyte Donor Application Discrepancies overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-25 date: 2024-05 date: 2025-05 date: 2024-04-12 date: 2024-04-12 name: Inception Fertility, LLC class: INDUSTRY name: GeneScreen Counseling, LLC briefSummary: Retrospective observational study comparing information received on Inception Central Donor Recruitment's standardized online egg donor application compared to information reported during a genetic risk assessment consultation with a certified genetic counselor with contracted third party genetic counseling service, GeneScreen. All donor applicants completing a full application with Inception's Central Donor Recruitment and a GRA consultation with GeneScreen will be included. conditions: Infertility studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 1000 type: ESTIMATED measure: Rate of additional information measure: Rate of applicant decline sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Inception Fertility LLC city: Houston state: Texas zip: 77081 country: United States lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06362538 id: MCH-ProCardioPrev briefTitle: The Cardiovascular Prevention Program overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2027-04-15 date: 2027-04-15 date: 2024-04-12 date: 2024-04-16 name: Maria Cecilia Hospital class: OTHER briefSummary: Cardiovascular diseases represent one of the main public health problems being the leading cause of morbidity, disability and mortality. In recent decades, the global prevalence and cardiovascular disease mortality has increased, with 23.6 million annual deaths expected by 2030. In Europe, mortality per year is equal to 2.2 million women and 1.9 million men, representing 47% and 37% of all deaths respectively. In Italy, the situation in terms of deaths due to cardiovascular diseases it is in line with the world ranking and European, being responsible for 44% of all deaths. The only interventional or pharmacological approach is neither effective nor sustainable. The most deaths from cardiovascular diseases are due to atherothrombotic events, which are attributable to a series of risk factors, most of which are modifiable. Turns out itself as a targeted action on these factors with the aim of safeguarding the state of health cardiovascular, may represent the best applicable strategy. It is therefore necessary structure and activate prevention programs aimed at the general population and groups of subjects at higher risk. conditions: Cardiovascular Prevention studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SEQUENTIAL primaryPurpose: PREVENTION masking: NONE count: 150 type: ESTIMATED name: International Physical Activity Questionnaire name: Six minute walking test name: SF-36, Euro-Qol 5D-5L, Perceived stress scale-10, Pittsburgh Sleep Quality Index, Depression Anxiety Stress scale- 21. name: MEDAS name: Intima-media thickness (IMT) name: Blood sampling name: Stool Sample Culture Test measure: measure of body mass index measure: Adherence to the Mediterranean diet measure: blood test to check cholesterol levels measure: blood pressure measurement measure: blood glucose test sex: ALL minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT hasResults: False
nctId: NCT06362525 id: 2022-389 briefTitle: Incidence of Episodes of (Dis)Connected Consciousness Among Emergency Patients Admitted in the Resuscitation Room overallStatus: RECRUITING date: 2023-10-09 date: 2025-09-30 date: 2027-09-30 date: 2024-04-12 date: 2024-04-12 name: University of Liege class: OTHER name: Centre Hospitalier Universitaire de Liege briefSummary: This observational study aims to describe the incidence of episodes of disconnected consciousness (including near-death experience (NDE)) and episodes of connected consciousness in patients admitted to the resuscitation room, who survived a critical condition and who meet at least one of these criteria during their stay in the resuscitation room: (1) deep sedation, (2) intubation, (3) cardiopulmonary resuscitation, or (4) (non-drug-induced) Glasgow Coma Scale score = 3. We also investigate the potential (neuro)physiological markers and biomarkers. In order to help determine the potential risk factors of such episodes, cognitive factors such as dissociative propensity are also investigated. Unexpected visual and auditory stimuli will be displayed. In addition, we assess the evolution of memory, as well as short- and long-term consequences on quality of life, anxiety, and attitudes towards care.
Finally, (neuro)physiological parameters of a subsample of dying patients are also investigated. conditions: Critical Illness conditions: Near-Death Experience conditions: Consciousness, Loss of conditions: Quality of Life conditions: Emergencies studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED measure: Detection of potential episodes of disconnected consciousness measure: Detection of potential episodes of connected consciousness measure: Risk factors measure: Quality of life assessment measure: Memory content and evolution assessment measure: Detection of post-traumatic stress disorder (PTSD) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU of Liège status: RECRUITING city: Liège zip: 4000 country: Belgium lat: 50.63373 lon: 5.56749 hasResults: False
nctId: NCT06362512 id: Marco_PANG_2024 briefTitle: Cognitive-motor Exercise for Stroke Patients in Function, Cognition and Related Brain Changes. acronym: COGMOTION overallStatus: RECRUITING date: 2024-04 date: 2026-04 date: 2026-04 date: 2024-04-12 date: 2024-04-16 name: The Hong Kong Polytechnic University class: OTHER briefSummary: The purpose of this study is to evaluate a cognitive-motor exercise on dual-task interference during dual-task ankle movement and the corresponding alterations of brain activity. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: After stratification according to gender and walking speed, the participants will be randomly allocated to one of three groups: (1) dual-task training, (2) single-task training, and (3) control intervention, using a 1:1:1 allocation ratio. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: This will be a single-blinded randomized controlled trial . The assessor will be blinded during assessments. The participants and investigators (trainers) are not possible to be blinded as it is an exercise intervention. whoMasked: OUTCOMES_ASSESSOR count: 84 type: ESTIMATED name: Dual-task training name: Single-task training name: Upper limb strengthening exercise measure: Dual-task step frequency measure: Dual-task cognitive performance accuracy measure: Blood oxygenation level changes of the brain measure: Single-task walking speed measure: Dual-task walking performance measure: Mini Balance Evaluation Systems Test measure: Activities-specific Balance Confidence Scale measure: Trail Making Test measure: Digit Span Test measure: Montreal Cognitive Assessment measure: Fall incidence measure: Dual-task ankle movement degree measure: Dual-task cognitive performance time sex: ALL minimumAge: 50 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Hong Kong Polytechnic University status: RECRUITING city: Hong Kong zip: 000000 country: China name: Marco Yiu Chung Pang, PhD role: CONTACT lat: 22.39407 lon: 114.13737 hasResults: False
nctId: NCT06362499 id: 01 briefTitle: Effects of Unsupervised Inspiratory Muscle Training on Ventilation Variability in Post-covid-19 Patients. overallStatus: RECRUITING date: 2024-04-01 date: 2024-07-31 date: 2024-07-31 date: 2024-04-12 date: 2024-04-17 name: Universidade Federal do Rio Grande do Norte class: OTHER briefSummary: Dysfunctional breathing and persistent hypocapnia can be associated with many of the symptoms experienced by patients such as dyspnea, fatigue, chest pain and palpitations. The identification of dysfunctional breathing and hypocapnia in these patients is important as it may represent a target for treatment.
In many of these patients, tachypnea at low levels of exertion suggests increased respiratory muscle activity, which can lead to the sensation of dyspnea. Sympathetic hyperactivity leads to excessive and irregular ventilation during exercise. In this way, inspiratory muscle training can improve symptoms (dysfunctional breathing), possibly by attenuating the metaboreflex (vagal modulation-attenuation of the sympathetic response) of the inspiratory muscle in post-covid-19 subjects, reducing ventilatory variability. conditions: COVID-19 studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: Experimental Group measure: Ventilation variability and ventilation efficiency measure: Respiratory muscle strength measure: Pulmonary function measure: Quality of life - Medical Outcomes Study 36-Item Short Health Form Survey (SF-36) measure: Peripheral muscle strength measure: Functional capacity measure: Adverse effects and adherence sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Federal University of Rio Grande do Norte status: RECRUITING city: Natal state: Rio Grande Do Norte zip: 59082-100 country: Brazil name: Gabriely Azevêdo role: CONTACT phone: 84999390004 email: gabrielyazevedo.ga@gmail.com name: Patrícia Nogueira role: CONTACT lat: -5.795 lon: -35.20944 facility: Patrícia Nogueira status: RECRUITING city: Natal state: Rio Grande Do Norte country: Brazil name: Patrícia Nogueira role: CONTACT name: Gabriely Azevêdo role: CONTACT phone: 5584999390004 email: gabrielyazevedo.ga@gmail.com lat: -5.795 lon: -35.20944 hasResults: False
nctId: NCT06362486 id: SIGNATURE briefTitle: Stress in Pregnancy During the Covid19 Pandemic and Impact on the Newborn Neurodevelopment overallStatus: ACTIVE_NOT_RECRUITING date: 2021-08-01 date: 2023-08-01 date: 2024-08-01 date: 2024-04-12 date: 2024-04-12 name: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla class: OTHER briefSummary: The Covid19 pandemic, paradoxically, represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge about the relationship between inflammation, brain development and an increased risk of suffering from neuropsychiatric disorders or alterations. In addition, the current availability of sophisticated biological techniques and evaluation procedures represents an unique option for this purpose.
Here, we propose a cohort study of sars-cov-2 (type 2 coronavirus causing severe acute respiratory syndrome) infected pregnant women and newborns. We will try to answer the following questions: (i) what is the inflammatory / immune status of newborns (NBs) of mothers infected by Covid19 like?; (ii) is there a relationship between the clinical characteristics of the maternal infection (severity / moment / of infection) and the inflammatory status of the newborn?; (iii) could these features increase the vulnerability to developing central nervous system (CNS) alterations at an early age, and at some point during adult life ?; (iv) How is the Covid19 infected mother's placenta altered? Do the placental alterations Covid19 mediated contribute to develop CNS alterations?; (v) is the infection associated with phenotypes obtained through neurological and neurodevelopmental clinical evaluation (hypotonia, clumsiness, impaired communication and sociability) in children at 6 months and 12 months?