hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06343831 id: IRB23-1646 briefTitle: Quantitative Assessment of Autologous Fat Transfer overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-12 date: 2026-12 date: 2024-04-03 date: 2024-04-03 name: University of Chicago class: OTHER name: National Institutes of Health (NIH) name: University of Houston briefSummary: This is a single-arm, prospective pilot study that will objectively assess outcomes in patients electively undergoing Autologous Fat Transfer (AFT) for breast or chest wall reconstruction. Patients planning to undergo autologous fat transfer for breast or chest wall reconstruction will be enrolled prospectively. Participants will undergo standard photographs (2-D imaging) of their chest wall and torso, including the breasts, and complete a validated questionnaire (BREAST-QTM) to evaluate patient satisfaction, and quality of life, all standard of care. The 3D photographs, Magnetic resonance imaging (MRI), and Ultrasound (US) are routinely used in practice but will be performed for research purposes in this study. All imaging procedures and questionnaires will be obtained at baseline and follow-up visits 3-6. conditions: Autologous Fat Grafting studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Patients planning to undergo autologous fat transfer for breast or chest wall reconstruction will be enrolled prospectively. Participants will undergo standard photographs (2-D imaging) of their chest wall and torso, including the breasts, and complete a validated questionnaire (BREAST-QTM) to evaluate patient satisfaction, and quality of life, all standard of care. The 3D photographs, MRI, and US are routinely used in practice but will be performed for research purposes in this study. primaryPurpose: OTHER masking: NONE count: 15 type: ESTIMATED name: 2-Dimensional (2-D) Photographs (Visit 1/ Follow up Visit 3-6) name: 3-Dimensional (3-D) Photographs (Visit 1- 6) name: Ultrasound Soft Tissue Assessment (Visit 1/ Follow up Visit 4-6) name: Magnetic Resonance Imaging Volume Assessment (Visit 1/ Follow up Visit 4-6) name: BREAST-QTM questionnaire (Visit 1/ Follow up Visit 4-6) measure: Change from baseline in breast/chest wall following autologous fat grafting, measured by imaging. measure: Change from baseline in quality of life as measured by the BREAST-QTM survey. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06343818 id: NIHR301578 briefTitle: Compassion Project: Developing an Empathy-Based Stress Intervention overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2026-08-01 date: 2027-08-31 date: 2024-04-03 date: 2024-04-03 name: University of Bath class: OTHER name: National Institute for Health Research, United Kingdom name: Oxford Health NHS Foundation Trust name: Central and North West London NHS Foundation Trust briefSummary: Compassion is recognising that someone is suffering and wanting to help them. Compassion fatigue is a reduction in capacity to feel compassion for others. Secondary trauma is the experience of traumatic responses to hearing about someone else's trauma. Burnout is depersonalisation, emotional exhaustion, and feeling less good at one's job. Compassion fatigue, secondary trauma and burnout can all be referred to as empathy-based stress. This is a problem for healthcare staff and their patients.
This pilot study aims to test and improve our intervention on two CAMHS wards, measuring how useful and well-liked it is, and how feasible it would be to use it and to test it on more wards. Staff on CAMHS wards will be offered a modular intervention including psychoeducation about empathy based stress and ways of combatting it, and workplace stressor and management toolkits. NHS CAMHS ward staff and patients will be asked to complete questionnaires and a subsample of staff will be asked to complete interviews about the process of the intervention. conditions: Reduction of Empathy-Based Stress in Healthcare Staff studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: The study uses a repeated AB design on two ward sites to assess feasibility, acceptability and usefulness of a novel intervention for empathy-based stress in staff, and to test feasibility of this study design. It is not assessing efficacy. The extended baseline measure is the control, there is no control group primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: The Compassion Project: Intervention to Reduce Empathy-Based Stress in Staff measure: Acceptability of intervention measure: Feasibility of intervention measure: Perceived usefulness of intervention measure: Feasibility of Study measure: Feasibility of gathering data on staff empathy-based stress using the Professional Quality of Life Scale at multiple timepoints measure: Feasibility of assessing health economics data using a Health-related Quality of Life questionnaire measure: Process measures to assess potential mechanisms of change measure: Feasibility of gathering young person and parent/carer data on compassionate care measure: Feasibility of gathering young person and parent/carer data on experience of service measure: Ward-level contextual factors sex: ALL minimumAge: 13 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06343792 id: RLS-0071-203 briefTitle: Safety, PK, PD, Dosing, and Efficacy of RLS-0071for the Treatment of Hospitalized Patients With Steroid-Refractory Acute Graft-versus-Host Disease acronym: AURORA overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-04 date: 2025-09 date: 2024-04-03 date: 2024-04-03 name: ReAlta Life Sciences, Inc. class: INDUSTRY briefSummary: This study is a Open Label Prospective Dose-Ranging Escalation and Expansion Trial to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Dosing, and Efficacy of RLS-0071 for the secondary treatment of acute Graft-versus-Host Disease (aGvHD) in hospitalized patients who are steroid-refractory. conditions: Steroid Refractory GVHD studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 66 type: ESTIMATED name: RLS-0071 measure: Number of participants with treatment-related adverse events (TEAEs) and Treatment-Emergent Serious Adverse Events (TESAEs) measure: Overall Response Rate (ORR) of RLS-0071 measure: Incidence of refractoriness (to RLS-0071 +/- ruxolitinib) measure: Overall corticosteroid use measure: Initiation of additional or alternative treatment(s) for aGvHD (including an increase in steroid dose to >2 mg/kg methylprednisolone equivalent) measure: Change or shift in Stage for lower GI aGvHD, liver aGvHD, skin aGvHD, or upper GI aGvHD from baseline based on MAGIC Criteria measure: Attainment of Stage 0 or 1 lower GI aGvHD, liver aGvHD, skin aGvHD, or upper GI aGvHD measure: Change or shift in overall Grade of aGvHD measure: Overall survival measure: Non-relapse mortality measure: Duration of hospital stay sex: ALL minimumAge: 12 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06343766 id: RECO6U/24-2022 briefTitle: Polymorphisms in ENAM, AMBN, and KLK4 Contribute to DCS. overallStatus: COMPLETED date: 2022-11-06 date: 2023-11-05 date: 2023-11-05 date: 2024-04-03 date: 2024-04-03 name: Amina Fouad Farag class: OTHER briefSummary: A Cross-Sectional Study aims to shed light on potential genetic determinants influencing dental caries susceptibility within this demographic and significantly understanding of genetic factors associated with dental caries, particularly within the context of the Egyptian population, providing valuable insights into the genetic aspects of oral health. The research methodology involved a comprehensive examination of these polymorphic loci ENAM, AMBN, TUFT1 and KLK4 and their prevalence, employing rigorous statistical analyses to establish potential correlations between these genetic variants and susceptibility to dental caries. conditions: Dental Caries Secondary to Polymorphisms conditions: Polymorphisms in Enamel Encoding Genes studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 204 type: ACTUAL name: DNA collation and genotyping measure: Polymorphisms in genes associated with enamel formation and mineralization and dental caries susceptibility. sex: ALL minimumAge: 15 Years maximumAge: 22 Years stdAges: CHILD stdAges: ADULT facility: Faculty of Dentistry, October 6 University city: Giza zip: 12511 country: Egypt lat: 30.00808 lon: 31.21093 hasResults: False
nctId: NCT06343753 id: FMASU MD46/2024 briefTitle: Quality of Recovery After Laparoscopic Cholecystectomy Comparing Opioid Free Analgesia Versus Opioid Free Anesthesia overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-10-01 date: 2024-04-03 date: 2024-04-03 name: Ain Shams University class: OTHER briefSummary: The aim of this study is to compare the quality of recovery from general anesthesia and surgery using the quality of recovery 15 item scale (QoR-15) for participant's receiving opioid-Sparing anesthesia with those receiving standard opioid-containing anesthesia in Patients undergoing a scheduled laparoscopic cholecystectomy. conditions: Quality of Recovery conditions: Pain, Postoperative conditions: Elective Laparoscopic Cholecystectomy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Opioid free analgesia name: Opioid based Anesthesia measure: Quality of recovery measure: Post operative pain measure: Postoperative Hypoxia measure: Postoperative nausea and vomiting measure: Postoperative bradycardia measure: Postoperative hypotension measure: Postoperative hypertension sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ain Shams University city: Cairo country: Egypt name: Ahmed El-ghanam role: CONTACT phone: 201116171706 lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06343740 id: PSY-2324-S-0136 briefTitle: First Evaluation of COMET-Y acronym: COMET-Y overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-12 date: 2024-04-03 date: 2024-04-03 name: Accare class: OTHER briefSummary: The goal of this pilot study is to evaluate COMET-Y in 22 adolescents (11-18 years) with various mental health problems and low self-esteem. The main questions is: Does COMET-Y, parallel to care as usual (CAU), improve self-esteem?
Before and after the training participants fill in questionnaires to measure self-esteem, mental health problems, resilience, quality of life, emotions and individual goals. Some of the outcomes are measured through diary methods. Youth and therapists will be assessed to evaluate feasibility and acceptability of the COMET-Y training. conditions: Self Esteem conditions: Quality of Life studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This pilot study is a pre-post study. primaryPurpose: TREATMENT masking: NONE count: 22 type: ESTIMATED name: COMET-Y measure: Self Esteem measure: Domain-specific Self Esteem measure: Mental Health Problems measure: Quality of life measure: Affect measure: Resilience measure: Ecological Momentary Assessments - Global self-esteem measure: Ecological Momentary Assesments - Goal Based Outcome (GBO) tool for young people measure: Ecological Momentary Assesments - Domain-specific self-esteem sex: ALL minimumAge: 11 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06343727 id: HS25870 (H2023:026) briefTitle: A High Protein Egg White Pudding for People With Kidney Failure (HiPE KF) overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-07-01 date: 2024-04-03 date: 2024-04-03 name: Seven Oaks Hospital Chronic Disease Innovation Centre class: NETWORK name: University of Manitoba name: Manitoba Egg Farmers briefSummary: The goal of this clinical trial is to compare protein supplements in patients with kidney failure on dialysis. The main questions it aims to answer are:
* To determine the effects of the egg white protein pudding on frailty measures, dietary intakes and analytes in the blood and urine. Participants will receive either the egg white pudding (experimental) or control (Ensure plus) at the end of their dialysis treatments 3-days per week for 12 weeks. conditions: Kidney Failure conditions: Frailty conditions: Kidney Disease, Chronic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This trial is an open-label randomized controlled parallel arm feasibility tria primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 54 type: ESTIMATED name: Egg white protein pudding name: : Ensure Plus measure: Eligibility to randomization ratio measure: Weekly recruitment rate measure: Adherence to Egg pudding measure: Serum albumin measure: Hand grip strength measure: Change in gait speed measure: Five rep chair stand time measure: Tandem balance time measure: Serum bicarbonate measure: Calcium measure: Urine albumin measure: chloride measure: phosphorus measure: Potassium measure: Sodium measure: HbA1c sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06343714 id: FB1003-04-101 briefTitle: A Study of FB1003 in Healthy Subject overallStatus: NOT_YET_RECRUITING date: 2024-04-03 date: 2025-06-30 date: 2025-06-30 date: 2024-04-03 date: 2024-04-03 name: 4B Technologies Limited class: INDUSTRY briefSummary: The purpose of this study is to evaluate safety and tolerability of FB1003 when given subcutaneously to healthy participants. Blood tests will be done to examine blood exposure, concentration and half-life of FB1003 following administrations. For each participant, the study will last up to about 12 weeks for single ascending dose part, and 18 weeks for multiple ascending dose part, including screening. conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 64 type: ESTIMATED name: FB1003 name: Placebo measure: The primary endpoint in the study is the incidence and severity of treatment emergent adverse events (TEAEs) in participants treated with FB1003 or placebo. measure: FB1003 serum concentrations over time measure: PK: Area Under the Concentration Versus Time Curve From Zero to Infinity (AUC0-∞) of FB1003 measure: Presence of anti-FB1003 antibodies over time sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT hasResults: False
nctId: NCT06343701 id: BAİBÜ-SAT4 briefTitle: Investigation of Motor Imaging Skills in Children With Spastic Cerebral Palsy overallStatus: RECRUITING date: 2023-07-18 date: 2024-05-05 date: 2024-06-25 date: 2024-04-03 date: 2024-04-03 name: Abant Izzet Baysal University class: OTHER briefSummary: The aim of this study was to investigate implicit and explicit motor imagery skills in children with spastic cerebral palsy and typically developing children. The main questions it aims to answer are:
* There is a difference between the explicit motor imagery skills of children with cerebral palsy and typically developing children. conditions: Cerebral Palsy, Spastic studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 90 type: ESTIMATED name: Implicit motor imagery name: Explicit motor imagery measure: Explicit motor imagery -1 measure: Explicit motor imagery - 2 measure: Explicit motor imagery - 3 measure: Implicit motor imagery sex: ALL minimumAge: 6 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Kdz. Ereğli Gökkuşağı Özel Eğitim ve Rehabilitasyon Merkezi status: RECRUITING city: Zonguldak state: Ereğli zip: 67300 country: Turkey name: Seda AYAZ TAŞ, Phd role: CONTACT phone: 05495458040 email: seda.ayaztas@ibu.edu.tr lat: 41.45139 lon: 31.79305 facility: Bolu Abant İzzet Baysal University status: RECRUITING city: Bolu state: Gölköy/ Bolu zip: 14030 country: Turkey name: Seda Ayaz Taş, Phd role: CONTACT phone: 05495458040 email: seda.ayaztas@ibu.edu.tr lat: 40.73583 lon: 31.60611 facility: Düzce Gökkuşağı Özel Eğitim ve Rehabilitasyon Merkezi status: RECRUITING city: Düzce state: Merkez zip: 81100 country: Turkey name: Seda AYAZ TAŞ, Phd role: CONTACT phone: 05495458040 email: seda.ayaztas@ibu.edu.tr lat: 40.83889 lon: 31.16389 hasResults: False
nctId: NCT06343688 id: BAIBU-FTR-SAT-5 briefTitle: "Immediate Effect of DAFO on Gross Motor Function and Balance in Diplegic Cerebral Palsy overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-01 date: 2025-04-01 date: 2024-04-03 date: 2024-04-03 name: Abant Izzet Baysal University class: OTHER briefSummary: " Study will investigate the immediate effect of DAFO usage on balance and gross motor functions in individuals with spastic diplegic cerebral palsy. The study is planned to be conducted with children aged 4-15 who have GMFCS levels 1 and 2 and who are willing to participate along with their families at the Turkey Spastic Children Foundation Metin Sabancı Special Education and Rehabilitation Center. During the dates of the study, children who meet the inclusion criteria will be evaluated. Demographic information such as age, height, and weight will be obtained for the participating children. To classify the gross motor levels of the children, the Gross Motor Function Classification System (GMFCS), the Manual Abilities Classification System (MACS) for hand skills, the Communication Function Classification System (CFCS) for communication skills, and the Eating and Drinking Ability Classification System (EDACS) for feeding skills will be used. In addition, the Gross Motor Function Measure (GMFM-88) items D and E for assessing motor skills, the Wii Balance Board for testing balance, the Pediatric Berg Balance Scale, and the functional reach test will be utilized. The balance and gross motor functions of the included children will be assessed in two different ways: with and without DAFO. Data analysis will be conducted by a blinded statistician who is not part of the research team. IBM SPSS 26 (Statistical Package for Social Sciences) will be used for statistical analysis of the data. Normality of continuous variables will be assessed using the Kolmogorov-Smirnov test. If continuous variables follow a normal (parametric) distribution, paired sample t-tests will be conducted on pre-test and post-test data. If the data are non-parametric, Wilcoxon test will be used. Pearson chi-square test or Spearman correlation coefficient will be used to determine the relationship between variables based on assumptions. Results will be evaluated at a significance level of p \< 0.05 with a 95% confidence interval." conditions: Diplegic Cerebral Palsy studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 38 type: ESTIMATED name: "Assessment of Balance and Lower Extremity Gross Motor Function with and without DAFO" measure: Wii Balance Board measure: "The Gross Motor Function Measure-88 (D-E) (GMFM-88) measure: The Functional Reach Test measure: "The Pediatric Berg Balance Scale (PBBS) measure: "The Eating and Drinking Ability Classification System (EDACS) measure: "The Manual Abilities Classification System (MACS) measure: "The Gross Motor Function Classification System (GMFCS) measure: "The Communication Function Classification System (CFCS) sex: ALL minimumAge: 4 Years maximumAge: 15 Years stdAges: CHILD hasResults: False
nctId: NCT06343675 id: Dnr 2024-00620-01 briefTitle: Systematic Health-promoting Work Environment Management in Dentistry overallStatus: RECRUITING date: 2024-04-04 date: 2024-12-31 date: 2024-12-31 date: 2024-04-02 date: 2024-04-05 name: Linkoeping University class: OTHER_GOV briefSummary: Research shows that the workplace is an important arena where much can be done to promote a sustainable working life while maintaining health. However, there is a lack of knowledge that is specific to dental care with regard to managers' and employees' perceptions of the work environment, systematic work environment management and work adaptations, as well as what measures in the workplace are necessary to create a health-promoting and sustainable work environment. There is also a lack of knowledge regarding what support employees and managers need in the systematic work environment management and what individual workplace adaptations that can work within dental care organizations. conditions: Occupational Health studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 200 type: ESTIMATED name: There is no intervention measure: Work Ability Single Item Scale (WAS) measure: Work Ability physical demands measure: Work Ability mental demands measure: Sick leave measure: Structured Multidisciplinary Work Evaluation Tool (SMET) measure: Satisfaction with work measure: Global Health measure: Perceived stress measure: Health problems related to work measure: Pain during last 7 days measure: Psychological safety measure: Work environment problems measure: Health related problems measure: Questions about workplace improvements, work adjustments, and support in the workplace measure: Work adjustment and discomfort measure: Support and meaning in work measure: Sustainable work life measure: Systematic work environment management and safety measure: Targeted questions to managers measure: Work environment responsibility and measures measure: Work environment management support and education measure: Background data measure: Semi-structured individual interview study with managers, sub-study 2 sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Occupational and Environmental Medicine Centre status: RECRUITING city: Linköping zip: 581 85 country: Sweden name: Anneli Peolsson, Prof., PhD role: CONTACT phone: +46700850599 email: Anneli.Peolsson@regionostergotland.se name: Carlotte Wåhlin, Assoc. Prof, PhD role: CONTACT phone: +46101036267 email: Charlotte.Wahlin@regionostergotland.se lat: 58.41086 lon: 15.62157 hasResults: False
nctId: NCT06343662 id: Meraki_Acquired Brain Injury briefTitle: Group Music Therapy for Acquired Brain Injury acronym: Meraki_ABI overallStatus: RECRUITING date: 2024-03-01 date: 2024-07 date: 2025-07 date: 2024-04-02 date: 2024-04-15 name: University of Valencia class: OTHER briefSummary: The study aims to analyse the impact of music therapy-based treatment on the comfort and well-being of patients with acquired brain injury (ABI). To achieve this objective, it is proposed to validate and implement a music therapy-based assessment and treatment protocol. The protocol will be tested in a pilot sample to improve adaptation to the disease and promote integration with the usual health measures of patients with ABI. Implementing a group treatment programme based on music therapy applied to patients with ABI. conditions: Acquired Brain Injury studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 80 type: ESTIMATED name: MERAKI_ABI measure: Change in Discomfort ( Baseline (3 Assessments), Pre- Post) measure: Barthel Index measure: Pfeiffer Short Form Mental State Questionnaire, SPMSQ measure: Charlson Comorbidity Index (CCI), sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Dr. Moliner status: RECRUITING city: Serra state: Valencia country: Spain name: Miguel Fombuena, PhD role: CONTACT email: fombuena_mig@gva.es name: Selene Valero-Moreno, PhD role: SUB_INVESTIGATOR name: Isabel Bellver Vercher role: SUB_INVESTIGATOR name: Ana Alegre Soler role: SUB_INVESTIGATOR name: José Jorge Botella Trellis, Dr. role: SUB_INVESTIGATOR name: Cristina Rocío Espejo Fernández, Dra. role: SUB_INVESTIGATOR name: María Carmen Badía Picazo, Dra. role: SUB_INVESTIGATOR lat: 39.68333 lon: -0.43333 hasResults: False