nctId: NCT06305221 id: opioid-free analgesia briefTitle: Effect of Opioid-free Analgesia and Anesthesia on the Quality of Postoperative Recovery and Nausea Vomit in Patients Receiving Laparoscopic Sleeve Gastrectomy overallStatus: RECRUITING date: 2024-03-09 date: 2025-03-31 date: 2025-03-31 date: 2024-03-12 date: 2024-04-16 name: Beijing Friendship Hospital class: OTHER briefSummary: The purpose of the intraoperative use of opioids is to reduce the amount of sedative medication and to ensure effective analgesia. But pain is an unpleasant sensory and emotional experience (a cognitive perception) that cannot occur with sufficient depth of anesthesia (even without opioids). So a more reasonable explanation for analgesia should be anti-nociception and the resulting inhibition of the response to surgical stress. Since multiple mediators are involved in nociceptive pathways, antinociception can also be acquired through multiple mechanisms. However, there is no single ideal harm drug to replace opioids, which often requires two or more drugs to meet clinical needs. While regional block attenuates the stress response to surgery and sympathetic activation because of afferents to block nociceptive stimuli, and has an important role in the implementation of OFA. Combined with the clinical characteristics of the LSG, investigators developed the transverse abdominis fascia block (transversus abdominis plane TAP) in combination with esketamine (esketamine), dexmedetomidine (dexmedetomidine, DEX) of opioid-free anesthesia (opioid free anesthesia, OFA) and the analgesic regimen (TEDOFA), Reduce patient pain scores, nausea and vomiting after LSG based on perfect analgesia and adequate anti-sympathetic response, As well as the other complications, Promote the accelerated postoperative recovery of patients undergoing LSG, And reduce the incidence and severity of postoperative chronic pain. conditions: Opioid-Free Anesthesia conditions: Laparoscopic Sleeve Gastrectomy conditions: Postoperative Vomiting conditions: Postoperative Recovery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 76 type: ESTIMATED name: Opioid-free Analgesics (esketamine, dexmedetomidine) name: Opioid Anesthetics (sufentanil and remifentanil) measure: 15-item recovery quality scale score 48 hours after surgery measure: 15-item recovery quality scale score 24 hours before surgery measure: Dosage of postoperative analgesics measure: Duration of until postoperative PACU Aldrete score> 9 points measure: anesthesia-related complication measure: time to first exhaust gas after surgery measure: time of first postoperative mobilization measure: Overall benefit of analgesic score satisfaction in pain treatment measure: Acute pain numeric rating scale score measure: Rhodes Index of Nausea, Vomiting, and Retching measure: Rhodes Index of Nausea, Vomiting, and Retching sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: bijia Song status: RECRUITING city: Beijing country: China name: bijia Song role: CONTACT phone: 18309845273 email: songbijia@163.com lat: 39.9075 lon: 116.39723 hasResults: False