hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06386484 id: 2019-05463 briefTitle: Selective Head-and-neck Cooling on Biomarker Levels and Symptom Rating Following a Boxing Bout overallStatus: RECRUITING date: 2021-11-02 date: 2025-01-01 date: 2025-01-30 date: 2024-04-26 date: 2024-04-26 name: Region Skane class: OTHER briefSummary: Young, healthy elite boxers ≥ 18 years old are recruited. Prior to, and immediately after a competitive boxing bout over 3x2 or 3x3 minutes, blood samples are drawn. Boxers are randomized to intervention or control management by 1:1 allocation prior to baseline testing. After the initial post-fight blood sample is drawn and symptom rating using the sports concussion assessment tool-5 (SCAT-5) has been collected, the boxers receive either acute selective head-and-neck cooling for 45 min, or routine post-fight management. The number of head impacts are counted in all boxers on match video recordings. In both groups, blood samples are drawn 45 minutes after the initial post-bout blood sample, as well as 3 and 6 days post-fight. conditions: Repetitive Head Impact conditions: Selective Head and Neck Cooling studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The PolarCap System consists of a high-powered portable cooling system, designed to reduce brain temperature by controlled cooling of the scalp and neck with a circulating coolant (PolarCap Coolant, PolarCool AB, Lund, Sweden). The coolant is maintained at 0°C and flows through a silicone-based head cap. An insulating neoprene cover is put on top of the cap for isolation. primaryPurpose: PREVENTION masking: TRIPLE whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: PolarCap System measure: Selective head-and-neck cooling in boxing attenuates the release of brain injury biomarkers such as NFL and GFAP post fight. measure: Selective head-and-neck cooling improves symptom rating post fight in boxing, using the Sports Concussion Assessment tool- 5 (SCAT-5). sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Department of Clinical Sciences Lund, Department of Neurosurgery, Sweden status: RECRUITING city: Lund state: Skane zip: 22100 country: Sweden name: Ali Al-husseini, MD, Medical doctor, PhD stud role: CONTACT phone: +46707267261 email: Ali.al-husseini@med.lu.se name: Ali Al-husseini role: SUB_INVESTIGATOR lat: 55.70584 lon: 13.19321 hasResults: False
nctId: NCT06386471 id: 24093 briefTitle: Personalized GI Motility Responses to Diet overallStatus: RECRUITING date: 2024-03-07 date: 2024-06-12 date: 2025-06-02 date: 2024-04-26 date: 2024-04-26 name: University of Illinois at Urbana-Champaign class: OTHER briefSummary: The goal of this randomized, crossover, clinical trial is to link: 1) gastrointestinal motility patterns induced by acute consumption of whole and refined grains, 2) enteric microbial production of bioactive metabolites, and 3) circulating postprandial appearance of metabolites important to cardiometabolic health including glucose, triglycerides, and cholesterol.
Participants will be asked to consume a Smartpill monitoring device that records metrics of gastrointestinal motility in response to whole or refined grains, monitor cardiometabolic metabolties over an 8 hour postprandial window, and provide a fecal sample for microbiome-related analyses. conditions: Nutritional and Metabolic Diseases conditions: Gastrointestinal Dysfunction conditions: Cardiovascular Diseases conditions: Dysbiosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Randomized, controlled, crossover primaryPurpose: BASIC_SCIENCE masking: NONE maskingDescription: Appearance, flavor, and texture of whole grain vs refined bread could not be masked count: 50 type: ESTIMATED name: Whole grain rye bread name: Refined grain rye bread measure: Gastrointestinal Pressure (mmHg) measure: Luminal pH (pH units) measure: Temperature (degrees celcius) measure: Gastrointestinal Transit Time (hours:minutes) measure: Blood Glucose measure: Triglycerides measure: Total Cholesterol measure: HDL cholesterol measure: LDL cholesterol measure: Lipopolysaccharide Binding Protein measure: Microbiome measure: Metabolomics sex: ALL minimumAge: 21 Years maximumAge: 63 Years stdAges: ADULT facility: University of Illinois at Urbana-Champaign status: RECRUITING city: Urbana state: Illinois zip: 61801 country: United States name: Brett R Loman, PhD, RD role: CONTACT name: Brett R Loman, PhD, RD role: PRINCIPAL_INVESTIGATOR lat: 40.11059 lon: -88.20727 hasResults: False
nctId: NCT06386458 id: AT-01 briefTitle: Assessing AThrough Radiofrequency Transseptal Puncture System for Left Atrial Access overallStatus: COMPLETED date: 2022-07-08 date: 2023-05-09 date: 2023-05-11 date: 2024-04-26 date: 2024-04-26 name: Hangzhou NOYA MedTech Co. Ltm. class: INDUSTRY briefSummary: This study is a prospective, multicenter, randomized controlled trial with a non-inferiority design. Participants are patients scheduled for atrial septal puncture. After signing informed consent, subjects will be randomly assigned to either the radiofrequency transseptal puncture system group (referred to as the trial group) or the traditional mechanical transseptal puncture system group (referred to as the control group). All participants will undergo immediate postoperative and discharge clinical follow-ups. conditions: Heart Diseases conditions: Atrial Fibrillation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 177 type: ACTUAL name: AThrough radiofrequency transseptal puncture system name: Traditional mechanical transseptal puncture needle measure: Transseptal puncture success rate. measure: Initial transseptal puncture success rate. measure: Time required to successfully complete the transseptal puncture. measure: Number of attempts needed to successfully complete the transseptal puncture. measure: Ratio of atrial septal puncture failures that cross over to the opposite group. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The 7th People's Hospital of Zhengzhou city: Zhengzhou state: Henan zip: 450000 country: China lat: 34.75778 lon: 113.64861 facility: The First Affiliated Hospital with Nanjing Medical University city: Nanjing state: Jiangsu zip: 210000 country: China lat: 32.06167 lon: 118.77778 facility: Tianjin Chest Hospital city: Tianjin state: Tianjin country: China lat: 39.14222 lon: 117.17667 facility: The First Affiliated Hospital of Ningbo University city: Ningbo state: Zhejiang zip: 315000 country: China lat: 29.87819 lon: 121.54945 hasResults: False
nctId: NCT06386445 id: XJTU1AF-CRF-2023-XK013 briefTitle: Study on the Serum Metabolic Markers and Early Complications After Allo-HSCT： Cohort Study overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-12-31 date: 2026-12-31 date: 2024-04-26 date: 2024-04-26 name: First Affiliated Hospital Xi'an Jiaotong University class: OTHER briefSummary: This study aims to establish a cohort of 500 patients with hematological disease who undergoing allogeneic hematopoietic stem cell transplantation in the northwest region. All patients will be followed up at the outpatient clinic once a week after transplantation until 100 days after transplantation to observe the presence of acute graft versus host disease, acute kidney damage, and major cardiovascular adverse events. Serum samples from the day before pre-treatment, day after pre-treatment, 2 weeks，4 weeks，8 weeks and 12 weeks after transplantation will be detected by metabolomics sequencing.The primary objective is to explore the serum metabolic markers of acute graft versus host disease，acute kidney injury, and major adverse cardiac events within 100 days after transplantation，the secondary objective is to observe the high-risk factors for early complications. conditions: Stem Cell Transplant Complications conditions: Acute Graft Versus Host Disease conditions: Acute Kidney Injury conditions: Major Adverse Cardiac Events studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 500 type: ESTIMATED name: Serum metabolomics sequencing measure: acute graft versus host disease measure: acute kidney injury measure: major adverse cardiac events sex: ALL minimumAge: 0 Years maximumAge: 65 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06386432 id: RG1124189 id: NCI-2024-02453 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: RG1124189 type: OTHER domain: Fred Hutch/University of Washington Cancer Consortium id: U54CA132381 type: NIH link: https://reporter.nih.gov/quickSearch/U54CA132381 briefTitle: EQQUAL-NM for the Promotion of Smoking Cessation in Sexual and Gender Minority Young Adults in New Mexico overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2025-12-01 date: 2025-12-01 date: 2024-04-26 date: 2024-04-26 name: Fred Hutchinson Cancer Center class: OTHER name: National Cancer Institute (NCI) name: National Cancer Institute Center to Reduce Cancer Health Disparities name: New Mexico State University briefSummary: This clinical trial assesses the acceptability and efficacy of Empowered, Queer, Quitting, and Living--New Mexico (EQQUAL-NM), a smoking cessation intervention for sexual and gender minority young adults in New Mexico. Smoking prevalence among sexual and gender minority (SGM) adults in New Mexico is more than twice as high as non-SGM adults. Helping young adult tobacco users to quit is critical, yet there have been few efforts to develop tailored treatments specifically for this population. EQQUAL-NM is a digital smoking cessation intervention designed specifically for SGM young adult smokers in New Mexico and may help them quit smoking. conditions: Cigarette Smoking-Related Carcinoma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE maskingDescription: Any outcome evaluator who has contact with participants will remain blinded to treatment group assignment until the final set of questions regarding acceptability of specific program components is asked. whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: Smartphone App-delivered Smoking Cessation Intervention name: Smartphone App-delivered Smoking Cessation Intervention name: Health Promotion and Education name: Health Promotion and Education name: Biospecimen Collection name: Questionnaire Administration measure: Participant satisfaction measure: Number of logins to the assigned application measure: Self-reported 7-day point prevalence abstinence (PPA) from all nicotine and tobacco products measure: Biochemically confirmed 7-day point prevalence abstinence (PPA) from all nicotine/tobacco products measure: Self-reported 30-day PPA from all nicotine/tobacco products measure: Biochemically confirmed 30-day PPA from all nicotine/tobacco products measure: Self-reported 7-day PPA from cigarette smoking measure: Self-reported 30-day PPA from cigarette smoking measure: Change in Contemplation Ladder scores measure: Change in acceptance of tobacco-use triggers measure: Change in values-guided action sex: ALL minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Fred Hutch/University of Washington Cancer Consortium city: Seattle state: Washington zip: 98109 country: United States name: Jaimee Heffner role: CONTACT phone: 206-667-7314 email: jheffner@fredhutch.org name: Jaimee Heffner role: PRINCIPAL_INVESTIGATOR lat: 47.60621 lon: -122.33207 hasResults: False
nctId: NCT06386419 id: CKJX839A1IN03 briefTitle: A Clinical Study to Evaluate the Safety and Effectiveness of Inclisiran Sodium in Indian Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2025-08-08 date: 2025-08-30 date: 2024-04-26 date: 2024-04-26 name: Novartis Pharmaceuticals class: INDUSTRY briefSummary: This study is to generate post-marketing safety and effectiveness data of inclisiran sodium in Indian patients as per approved indication i.e., primary hypercholesterolemia (heterozygous familial and non-familial) or mixed dyslipidemia that more closely resembles the real-world population intended to be treated with inclisiran sodium. conditions: Primary Hypercholesterolemia conditions: Mixed Dyslipidemia studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: open label assignment primaryPurpose: TREATMENT masking: NONE count: 65 type: ESTIMATED name: inclisiran measure: Incidence and type of treatment-emergent adverse events (TEAEs) measure: Mean change in LDL-C from baseline to Day 300. measure: Proportion of the participants with ≥50% LDL-C reduction on Day 300 measure: Proportion of the participants who attain global lipid targets for their level of atherosclerotic cardiovascular disorders (ASCVD) risk measure: Percentage change in TC, HDL-C, non-HDL-C, VLDL-C and TG sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06386406 id: ORL-ORT-040 briefTitle: This is a Study to Evaluate a Pre-confectioned Plantar Insole for the Treatment of Plantar Heel Pain acronym: TAP overallStatus: RECRUITING date: 2024-04-23 date: 2026-03-31 date: 2026-03-31 date: 2024-04-26 date: 2024-04-26 name: Ente Ospedaliero Cantonale, Bellinzona class: OTHER briefSummary: Patients affected by plantar heel pain will be asked to use a pre-confectioned plantar insole for one year.
The aim of the study is to assess if the insole under study allows the patient to reach a better mobility and a faster return to the normal everyday life. conditions: Plantar Fascitis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 25 type: ESTIMATED name: TAP insole measure: Change in pain severity according to visual analog scale measure: Change in pain severity according to visual analog scale measure: Subjective functional recovery based on the Foot Function Index (FFI) score [ measure: Quality of life and foot general health through the assessment of the Foot Health Status Questionnaire (FHSQ) measure: Patient satisfaction on a 0-10 numeric rating scale (NRS) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: EOC status: RECRUITING city: Lugano zip: 6900 country: Switzerland name: Martin Riegger, Dr.med role: CONTACT phone: +41 (0) 91 811 70 29 email: RicercaOrtopedia.ORL@eoc.ch lat: 46.01008 lon: 8.96004 hasResults: False
nctId: NCT06386393 id: HHSP233201500048I-75P00120F370 briefTitle: Survey on Where Parents Look for and Find Information and How They Use Information When Selecting Child Care overallStatus: ENROLLING_BY_INVITATION date: 2024-03-28 date: 2024-06-30 date: 2024-06-30 date: 2024-04-26 date: 2024-04-29 name: National Opinion Research Center class: OTHER name: Office of Planning, Research & Evaluation name: Urban Institute briefSummary: The Administration for Children and Families (ACF) within the U.S. Department of Health and Human Services (HHS) is contracting with NORC at the University of Chicago to collect nationally representative survey data to learn more about where parents look for and find information about Child Care and Early Education (CCEE); how parents assess the people, places, or things that may offer CCEE information; what types of CCEE information parents look for; and how parents use information to make CCEE selections. The study aims to gather information that may be used by Child Care Lead Agencies to inform their consumer education efforts. This study is part of the Consumer Education and Parental Choice in Early Care and Education (CEPC) project.
The study will select a nationally representative sample from NORC's probability-based AmeriSpeak panel. The AmeriSpeak panel provides sample coverage of approximately 97 percent of the U.S. population. It currently contains 48,900 panel members age 13 and over residing in over 40,000 households. U.S. households are randomly selected with a known, non-zero probability from the NORC National Frame, and then recruited by mail, telephone, and by field interviewers face-to-face. NORC's in-person recruitment enhances representativeness for young adults, lower socio-economic households, non-internet households, and other households that are typically hard to reach for statistical surveys of the population.
The survey respondents are AmeriSpeak panelists of at least 18 years of age who have indicated that they have a young child in the household (under the age of 6 years, but not in kindergarten). If a household has two or more panel members who reside in a household with a young child, one will be selected at random to complete the survey, with preference given to parents/legal guardians. Selected panelists will be asked questions to confirm eligibility for the survey, including that the household has at least one child under the age of 6 but not in kindergarten. The study is designed to include parents and legal guardians across race/ethnicity, education level, and gender from the full spectrum of geographic locations. To include families who may not have English as a preferred language, a Spanish version of the survey will be provided. The survey will include parents and legal guardians using many kinds of CCEE and those who use parental care only to see if there are differences in how information is used depending on care type. In addition, the study will include understudied subgroups, such as parents who speak a language other than English, to help inform consumer education efforts. The survey is intended to produce findings that are generalizable to the larger population of parents with children under the age of 6, but not in kindergarten. conditions: Searching for and Selecting Child Care in the US studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: CROSS_SECTIONAL count: 2196 type: ESTIMATED measure: Primary sources of information about child care measure: How parents assess the people, places, or things that may offer CCEE information measure: What types of CCEE related information parents look for measure: Information about the last time parents made a decision about CCEE and what information they tried to learn about at that time measure: Characteristics and experiences of the household and types of CCEE being used sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: NORC at the University of Chicago city: Chicago state: Illinois zip: 60603 country: United States lat: 41.85003 lon: -87.65005 hasResults: False
nctId: NCT06386380 id: IRE-4906 briefTitle: Adversity and Its Association With the Development and Expression of Rheumatic Diseases acronym: RD overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-01-01 date: 2026-02-01 date: 2024-04-26 date: 2024-04-26 name: National Institute of Medical Sciences and Nutrition, Salvador Zubiran class: OTHER briefSummary: Epidemiological evidence shows that adverse experiences, particularly, but not exclusively in childhood, are predictors of poor long-term health outcomes and certain social domains. In the field of rheumatic diseases, traumatic events, not only in childhood, have been associated with hospitalization, chronic pain, inflammation, worse outcomes, severity of the disease, and mortality. Some mechanisms proposed to explain the association between the experience of adversity and the development of chronic diseases include an impact on the physiology of immune system cells, gene expression due to DNA modification, and cellular senescence.
With this background, we wonder if, for patients with rheumatoid arthritis, the presence of adversity understood as a history of violence in childhood and abuse due to suffering from rheumatoid arthritis is associated with markers of cellular senescence and with the severity of illness. conditions: RhA - Rheumatoid Arthritis studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 110 type: ESTIMATED name: Rheumatic diseases Mistreatment Scale (RDMS) name: Routine assessment of patient index data 3 (RAPID-3) name: Health Assessment Questionnaire (HAQ) name: WHOQOL-BREF name: Depression, Anxiety and Stress Scale (DASS-21) name: Brief Resilient Coping Scale name: Expression of CDKN2A /p16INK4a name: Immunophenotype of leukocyte subpopulations name: Telomere length name: Cellular senescence measure: Adversity and senescence in patients with rheumatoid arthritis measure: Eexpression of the p16INK4a gene in CD3+ measure: Telomere length sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06386367 id: MHNO-001 briefTitle: Health Education by Buddhist Monks to Promote Malaria Knowledge and Preventive Practices in Rural Myanmar overallStatus: COMPLETED date: 2022-07-01 date: 2023-03-31 date: 2024-03-30 date: 2024-04-26 date: 2024-04-29 name: Myanmar Health Network Organization class: OTHER name: Chulalongkorn University name: Ministry of Health and Sports, Myanmar briefSummary: Malaria is still a leading public health concern in Myanmar. However, people living in rural areas usually showed poor prevention practice despite residing in malaria hotspots. The majority in Myanmar are Buddhists who frequently visit the monastery and receive the speech delivered by the monks. In a malaria high burden township of the Sagaing Region from northern Myanmar, current study will first explore the difference in malaria preventive practices among people residing in different malaria-endemic villages through a mixed-methods approach. Next, this research will address the knowledge gaps by a monastery-based health education delivered by trained Buddhist monks using standardized health messages instruction for six consecutive months between August 2022 to January 2023. To test whether the intervention could balance those gaps among different groups, quantitative data of baseline, 3-month, and 6-month will be compared using descriptive statistics, chi-square test, T-test or repeated ANOVA, and the Difference-In-Differences (DID) analysis, as applicable. conditions: Buddhist Monks conditions: Health Education conditions: Malaria conditions: Monastery-based conditions: Myanmar conditions: Preventive Practice studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE whoMasked: PARTICIPANT count: 501 type: ACTUAL name: Monastery-based health education by Buddhist monks measure: Malaria knowledge and preventive practices sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Myanmar Health Network Organization city: Yangon zip: 11091 country: Myanmar lat: 16.80528 lon: 96.15611 hasResults: False