hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06278766 id: M24-416 briefTitle: A Study to Assess the Mass Balance of [14C] ABBV-552 in Healthy Male Participants Following Single Oral Dose Administration overallStatus: COMPLETED date: 2024-02-21 date: 2024-04-19 date: 2024-04-19 date: 2024-02-26 date: 2024-04-29 name: AbbVie class: INDUSTRY briefSummary: The purpose of this study is to evaluate mass balance, pharmacokinetics and safety of \[14C\] ABBV-552 in healthy, male volunteers following administration of a single oral dose. conditions: Healthy Volunteer studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 8 type: ACTUAL name: ABBV-552 measure: Number of Participants with Adverse Events (AEs) measure: Maximum observed concentration (Cmax) of ABBV-552 measure: Time to Cmax (peak time, Tmax) of ABBV-552 measure: Terminal phase elimination rate constant (λz) of ABBV-552 measure: Terminal phase elimination half-life (t1/2) of ABBV-552 measure: Area under the plasma concentration-time curve (AUC) from time 0 to the time of the last measurable concentration (AUCt) of ABBV-552 measure: Area under the plasma concentration-time curve (AUC) from time 0 to infinite time (AUCinf) of ABBV-552 measure: Amount of ABBV-552 excreted in the urine over the sampling period (Aeu) measure: Percent of ABBV-552 excreted in the urine measure: Renal clearance ABBV-552 (CLr) measure: Amount of ABBV-552 excreted in the feces over the sampling period (Aef) measure: Percent radioactivity excreted in the feces sex: MALE minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Fortrea Clinical Research Unit Inc /ID# 262684 city: Madison state: Wisconsin zip: 53704 country: United States lat: 43.07305 lon: -89.40123 hasResults: False
nctId: NCT06278753 id: 2025/05/02 briefTitle: Comparison of Standard Cystoscopy With Carbon Dioxide Cystoscopy overallStatus: RECRUITING date: 2021-07-01 date: 2024-03-01 date: 2024-04-01 date: 2024-02-26 date: 2024-02-26 name: Tepecik Training and Research Hospital class: OTHER briefSummary: For the evaluation of the lower urinary tract after laparoscopic hysterectomy, routine standard saline cystoscopy and carbon dioxide cystoscopy will be compared. conditions: Bladder Injury conditions: Ureter Injury conditions: Surgical Injury conditions: Complication of Surgical Procedure studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED name: carbon dioxide cystoscopy measure: It was aimed to evaluate the effectiveness and reliability of carbon dioxide cystoscopy. measure: It was aimed to evaluate the speed and image quality of carbon dioxide cystoscopy in detecting intravesical masses. sex: FEMALE minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tepecik Training and Research Hospital status: RECRUITING city: İzmir state: Eurasia zip: 35090 country: Turkey name: Ali Turgut role: CONTACT phone: 02324696969 email: iyikliniktepecikeah@gmail.com lat: 38.41273 lon: 27.13838 hasResults: False
nctId: NCT06278740 id: SCIUSG24 briefTitle: Upper Extremity Pathologies in Spinal Cord Injuries overallStatus: NOT_YET_RECRUITING date: 2024-02-26 date: 2025-02-26 date: 2025-03-26 date: 2024-02-26 date: 2024-02-26 name: Afyonkarahisar Health Sciences University class: OTHER briefSummary: This study aims to determine the relationship between upper extremity pathologies and demographic data, duration of manual wheelchair use, duration of injury, physical examination and musculoskeletal ultrasound measurements in patients with spinal cord injuries. conditions: Spinal Cord Injuries conditions: Upper Extremity Problem conditions: Musculoskeletal Pain studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 174 type: ESTIMATED name: Musculoskeletal Ultrasound measure: Comparison of US findings among participants measure: Visual Analog Scale (VAS) measure: The Physical Examination of the Shoulder Scale (PESS) measure: The Quick Disability of the Arm, Shoulder, and Hand (Quick DASH) measure: American Spinal Injury Association (ASIA) Impairment Scale measure: The Spinal Cord Independence Measure (SCIM-III) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Afyonkarahisar Health Sciences University city: Afyonkarahisar zip: 03100 country: Turkey name: Mahmut Sami DOĞANLAR, MD role: CONTACT phone: +905512579828 email: mahmutdoganlar96@gmail.com name: Nuran EYVAZ, MD role: CONTACT phone: +905334262442 email: eyvaznuran@gmail.com lat: 38.75667 lon: 30.54333 hasResults: False
nctId: NCT06278727 id: SYSKY-2023-1173-01 briefTitle: Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Failure Patients Taking Guideline-directed Medical Therapy overallStatus: RECRUITING date: 2024-01-01 date: 2025-06-01 date: 2025-12-31 date: 2024-02-26 date: 2024-02-26 name: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University class: OTHER briefSummary: This observational study is to develop and validate the prediction model for functional mitral regurgitation regression in heart failure patients taking GDMT. The patients diagnosed ≥2+ functional mitral regurgitation by ultrasonic cardiogram are enrolled in this study and would be clinically followed by at least one year (clinical visit at 3 months, 6 months, and 12 months), and then by when the endpoints are reached. conditions: Mitral Regurgitation conditions: Heart Failure studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 270 type: ESTIMATED name: angiotensin-converting enzyme inhibitors/angiotensin II receptor blocker/angiotensin receptor-neprilysin inhibitor name: The development of the prediction model measure: FMR regression rate measure: FMR regression rate measure: composite endpoint sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sun-Yatsen Memorial Hospital status: RECRUITING city: Canton state: Guangdong country: China name: Maohuan Lin role: CONTACT lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06278714 id: 0012 briefTitle: Influence of an Inspiratory Muscle Fatigue Protocol on Healthy Youngs on Respiratory Muscle Strength and Heart Rate Variability overallStatus: NOT_YET_RECRUITING date: 2024-03-04 date: 2024-03-11 date: 2024-03-20 date: 2024-02-26 date: 2024-02-26 name: Sierra Varona SL class: OTHER name: Universidad Europea de Madrid briefSummary: Respiratory muscle training represents an effective method increasingly utilized in both sports and healthcare domains, employing various devices, among which threshold devices are prominent. The aim of this study is to determine the relationship between inspiratory muscle fatigue and maximal inspiratory pressure, diaphragmatic strength (guided by ultrasound image) and heart rate variability.
Measurements of variables, such as maximal inspiratory pressure, heart rate variability and diaphragmatic strength (ultrasound image), will be conducted. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: the outcome assessor will not know in which group is each participant, and the investigator will receive the data without knowing which data is from which group whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 18 type: ESTIMATED name: Inspiratory muscle training measure: Respiratory muscle strength measure: Diaphragmatic thickness and thickening fraction measure: Diaphragm movement curve measure: Heart rate variability sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT hasResults: False
nctId: NCT06278701 id: 2024-003-01 briefTitle: The Effect of Late-evening Snacks on Patients With Primary Hepatocellular Carcinoma After Hepatectomy overallStatus: ACTIVE_NOT_RECRUITING date: 2023-11-01 date: 2025-01-31 date: 2025-07-30 date: 2024-02-26 date: 2024-02-26 name: DU Yao class: OTHER briefSummary: Late-evening snacks, in which a portion of food is moved to bedtime while the total amount of food eaten per day remains unchanged, can effectively improve the metabolic state of accelerated catabolism.
* have follow-up examinations at 1 month, 3 months and 6 months after the operation, after which blood samples will be collected for metabolite testing. conditions: Liver Neoplasms studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This study utilizes a grouping method based on patient preference. You will learn about the 2 dietary modalities, the late-evening snacks and the regular diet, and then you will be placed in the different groups according to your preference. Patients who volunteer for the 1h bedtime meal will be in the test group and those who volunteer for the regular diet will be in the control group. Dietary counseling and follow-up visits will be conducted in both groups, the difference being the presence or absence of the 1h bedtime meal pattern. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 106 type: ESTIMATED name: late-evening snacks measure: Albumin rising measure: Prealbumin rising measure: Decrease in Alanine Aminotransferase measure: Decrease in Aspartate Aminotransferase measure: Decrease in Cholinesterase measure: Decrease in Total bilirubin measure: Lower total hospitalization costs measure: Relapse-Free Survival measure: Improved quality of life sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Drum Tower Hospital, Medical School of Nanjing University city: Nanjing state: Jiangsu zip: 210008 country: China lat: 32.06167 lon: 118.77778 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-12-22 uploadDate: 2024-02-02T09:22 filename: Prot_SAP_000.pdf size: 743937 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-12-22 uploadDate: 2024-02-04T04:41 filename: ICF_001.pdf size: 292546 hasResults: False
nctId: NCT06278688 id: 112R10438Y briefTitle: Precision Probiotic Supplementation in Individuals With Mild Cognitive Impairment overallStatus: NOT_YET_RECRUITING date: 2024-03-18 date: 2025-07-31 date: 2027-07-31 date: 2024-02-26 date: 2024-02-26 name: National Yang Ming University class: OTHER name: National Science and Technology Council name: Far Eastern Memorial Hospital briefSummary: The overarching goal of this randomized-controlled trial is to investigate the role and mechanism of the microbiota-gut-brain axis in MCI. The main questions it aims to answer are:
Aim 2: To determine the efficacy of precision probiotic supplementation on cognitive decline (primary outcome) and functional brain changes (secondary outcome) in individuals with MCI due to AD using a randomized, double-blind, placebo-controlled trial. Investigators plan to recruit 120 individuals with MCI due to AD, i.e., MCI with positive amyloid biomarkers. Participants will be randomized to a 12-month supplement of precision probiotics based on the individual gut probiotic profile or placebo. The primary outcome measure will be the changes in cognitive functions over 6 months (primary endpoint) and 12 months. The secondary outcome measure will be resting-state functional brain changes.
Aim 3: To investigate potential mediators underlying the effect of probiotic supplementation. The most apparent mediator will be a shift or changes in gut microbiota. Other potential mediators will be related to decreased lipopolysaccharide, proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6 and IL-10, and increased brain- derived neurotrophic factor, short-chain fatty acid, etc. conditions: Mild Cognitive Impairment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 120 type: ESTIMATED name: Precision probiotics measure: The changes in attention measure: The changes in memory measure: The changes in executive function measure: The changes in global cognition at the 12th month from baseline. measure: The changes in brain imaging at the 12th month from baseline. sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06278675 id: SEOVA briefTitle: Multiple Study of Electroaccpuncture in ARDS overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2026-06-30 date: 2026-12-31 date: 2024-02-26 date: 2024-04-23 name: Nanjing University of Traditional Chinese Medicine class: OTHER briefSummary: In order to clarify the clinical efficacy of electroacupuncture on inhibiting systemic inflammatory response, improving respiratory mechanics parameters and prognosis in patients with sepsis-related ARDS. conditions: Acute Respiratory Distress Syndrome conditions: Sepsis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 264 type: ESTIMATED name: Acupuncture needles measure: Respiratory mechanics indicators 1 measure: Respiratory mechanics indicators 2 measure: Respiratory mechanics indicators 3 measure: Respiratory mechanics indicators 4 measure: Respiratory mechanics indicators 5 measure: Respiratory mechanics indicators 6 measure: Respiratory mechanics indicators 7 measure: Sedation and analgesia measure: Sedative drug use measure: Analgesic drug use measure: Inflammatory factors measure: CD4、CD8、CD4/CD8 measure: Vasoactive drugs applications measure: CRRT applications measure: ECMO applications measure: All-cause mortality to day 28 measure: All-cause mortality to day 60 measure: ICU-free days measure: Hospital-free days sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine city: Nanjing state: Jiangsu zip: 210029 country: China name: Jun Lu, Doctor role: CONTACT phone: +86 13813865758 email: lujun@njucm.edu.cn lat: 32.06167 lon: 118.77778 hasResults: False
nctId: NCT06278662 id: CIRCUS cmRCT briefTitle: Cohort Multiple Randomized Controlled Trial in Pediatric Asthma acronym: CIRCUS overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2034-04-01 date: 2034-04-01 date: 2024-02-26 date: 2024-02-26 name: Mattienne van der Kamp class: OTHER briefSummary: The overarching goal of this study is to optimize pediatric asthma care and to continuously evaluate variations/innovations of the care (including transformation to remote eHealth care).
* Compose patient risk profiles that include both personal, clinical and exposome markers and clinical asthma endpoints (for example clinical admission/exacerbations). conditions: Pediatric Asthma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The CIRCUS study has a cmRCT design to determine the effects of (eHealth) interventions in asthmatic children. Children are included in the prospective dynamic cohort during outpatient visits. Children and/or their parents are asked to sign consent for three parts of the cmRCT, of which at least consent for part 1 is needed to be eligible for participation:
3. Willingness to fill out additional questionnaires and/or do additional measurements if a child is randomly selected for the control group of an intervention, which uses additional outcomes. primaryPurpose: DIAGNOSTIC masking: NONE maskingDescription: The masking is dependent of the future interventions. count: 300 type: ESTIMATED name: video directly observed therapy (vDOT) measure: Asthma control measure: Pediatric Asthma Quality of Life measure: Quality of care measure: Self-management capacity measure: Healthcare use measure: Wheather data measure: Air quality measure: Pollen measure: Medication delivery sex: ALL minimumAge: 4 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06278649 id: 2023-161-Multi-site briefTitle: Relaxation and Guided Imagery as an Intervention for Asthma overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2026-01-01 date: 2026-01-01 date: 2024-02-26 date: 2024-02-26 name: Pace University class: OTHER name: University of Connecticut name: Touro University briefSummary: The purpose of the current study is to investigate the usefulness of a Relaxation and Guided Imagery intervention for the reduction of asthmatic symptoms in adults and children whose asthma symptoms are aggravated, or triggered by anxiety. This study will replicate the previous literature to further investigate the impact that a Relaxation and Guided Imagery intervention can have on anxiety and related asthmatic symptoms using a multiple baseline (small sample size) research design. Participants will fill out questionnaires, listen to RGI audio tapes, and provide lung functioning samples by blowing into a spirometer. conditions: Asthma conditions: Anxiety studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 5 type: ESTIMATED name: Relaxation and Guided Imagery measure: Asthma measure: Asthma measure: Anxiety measure: Quality of Life sex: ALL minimumAge: 8 Years maximumAge: 80 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06278636 id: 5745 briefTitle: Laparoscopic Ultrasound Examination: Analysis of Feasibility acronym: LUXA overallStatus: RECRUITING date: 2023-07-18 date: 2024-12-30 date: 2025-01-30 date: 2024-02-26 date: 2024-02-26 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: This is a prospective cohort study to assess the feasibility of the laparoscopic ultrasound examination, directly by surgeons, during minimally invasive gynaecological surgery.
The secondary aims are to examine the learning curve for laparoscopic ultrasound examination and the performance score in obtaining high quality ultrasound images of anatomical parameters by a team of 5 gynecological laparoscopic fellows. The patients' medical history and symptoms will also be recorded to define whether these clinical data can influence the failure rate. With advanced technology, the conventional workflow can be simplified by using laparoscopic ultrasound probes directly by surgeons, to utilize the hospital resources efficiently and to reduce operating times. In this regard, we would like to demonstrate that the application of laparoscopic examination is feasible and easy to learn by surgeons. This innovative technique could open up multiple diagnostic and therapeutic opportunities for the patient, providing potential clinical information useful to the surgeon. conditions: Gynecologic Cancer conditions: Surgical Procedure, Unspecified studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 300 type: ESTIMATED name: Laparoscopi ultrasound examination measure: feasibility of the laparoscopic measure: the learning curve of fellow surgeons measure: the performance of fellow surgeons sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione Policlinico Universitario Agostino Gemelli, IRCCS status: RECRUITING city: Rome zip: 00168 country: Italy name: Floriana Mascilini, Dr role: CONTACT name: Antonia Carla Testa, Prof role: CONTACT name: Floriana Mascilini role: PRINCIPAL_INVESTIGATOR lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06278623 id: 4935 briefTitle: Focal Muscle Vibration in Parkinson's Disease overallStatus: RECRUITING date: 2023-05-11 date: 2025-12-01 date: 2025-12-01 date: 2024-02-26 date: 2024-02-26 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: Postural instability has a major impact on the mobility and daily life activities of Parkinson's disease (PD) patients as it often leads to reduced mobility, insecure stance and falls.
The aim of this study was to evaluate the effect of focal vibration on the static and dynamic balance of a group of Parkinson's disease patients with Hoehn and Yahr (HeY) stage II-III. They underwent three weeks of focal muscle vibration applied to the quadriceps, soles of the feet and trapezius muscles bilaterally in addition to conventional physiotherapy . The static and dynamic balance was assessed at baseline (T0), after 3 weeks of treatment (T1) and after 1 month from the last treatment (T2) with the Tinetti scale and stabilometry evaluations. conditions: Parkinson Disease conditions: Postural; Defect conditions: Rehabilitation studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 23 type: ESTIMATED name: Focal Muscle Vibratory Energy (EVM) Treatment measure: Tinetti scale measure: NRS numeric rating scale of pain measure: Stabilometric Test measure: Mc Gill Pain questionnaire sex: ALL minimumAge: 18 Months stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Gianpaolo Ronconi status: RECRUITING city: Roma zip: 00168 country: Italy name: gianpaolo ronconi role: CONTACT phone: +393477123940 email: gronconi@yahoo.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06278610 id: 3612 briefTitle: Pelvic Exenteration and Laterally Extended Pelvic Resection acronym: Pre-PEX overallStatus: RECRUITING date: 2020-11-19 date: 2024-12-30 date: 2025-01-31 date: 2024-02-26 date: 2024-02-26 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: Growing evidence in literature is supporting the role of ultrasound scan (US) as accurate tool in diagnosis and staging of gynecologic cancers. In particular, different studies demonstrated the accuracy of US in assessing endometrial, cervical, and ovarian cancer in the primary setting. However, the number of studies investigating the role of US in the recurrent setting is limited. Moreover, there is no evidence in literature exploring the role of US in laterally-extended pelvic recurrences from gynecologic cancer, where the Magnetic Resonance Imaging (MRI) scan is still considered the most accurate tool. conditions: Gynecologic Cancer conditions: Surgical Procedure, Unspecified studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 85 type: ESTIMATED name: PELVIC EXENTERATION measure: pelvic exenteration resection. measure: accuracy of US with the accuracy of MRI sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS status: RECRUITING city: Roma zip: 00168 country: Italy name: ANTONIA CARLA Pr TESTA role: CONTACT email: antoniacarla.testa@policlinicogemelli.it name: NICOLO' DR BIZZARRI role: CONTACT phone: 3471771680 email: nicolo.bizzarri@policlinicogemelli.it lat: 41.89193 lon: 12.51133 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2020-05-29 uploadDate: 2023-02-24T13:07 filename: Prot_000.pdf size: 598158 hasResults: False