hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06313229 id: KFSIRB200-195 briefTitle: Simultaneous Implant Placement With Vertical and Horizontal Bone Augmentation overallStatus: RECRUITING date: 2024-03-13 date: 2025-03-25 date: 2025-03-31 date: 2024-03-15 date: 2024-04-16 name: Kafrelsheikh University class: OTHER briefSummary: The purpose of this study was to report the clinical and radiographical outcomes of using autogenous cortical bone plates combined with sticky allogenic bone graft for augmenting maxillary anterior atrophic combined horizontal and vertical ridge defects with simultaneous versus staged implant placement. conditions: Alveolar Bone Loss conditions: Dental Implant Failed studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: single-center, prospective, single-blinded, randomized parallel two-arm controlled clinical trial primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: The present clinical trial was single-blinded one as the evaluator and the statistician were both blinded. While both the implantologist or the participant were not blinded as the interventions were dissimilar. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 42 type: ESTIMATED name: implant placement 6 months after ridge augmentation name: implant placement Simultaneously with ridge augmentation measure: Stability Quotient of Implants (SQI) measure: Horizontal bone dimensions (HBDs) measure: Peri-implant Bone Density (PBD) sex: ALL minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: faculty of dentistry, kafrelsheikh University status: RECRUITING city: Kafr Ash Shaykh state: Kafrelsheikh zip: 214312 country: Egypt name: Walid elamrousy, PhD role: CONTACT phone: +201091444946 email: perioking1@gmail.com name: Dalia Rasheed Issa, PhD role: CONTACT email: dalia_rasheed@hotmail.com lat: 31.11174 lon: 30.93991 hasResults: False
nctId: NCT06313216 id: KFSIRB200-187 briefTitle: Treatment of Peri-implant Bone Dehiscence Using Autogenous Tooth Plate overallStatus: RECRUITING date: 2024-03-15 date: 2025-03-30 date: 2025-04-15 date: 2024-03-15 date: 2024-04-09 name: Kafrelsheikh University class: OTHER briefSummary: The current trial aim was to evaluate clinically and radiographically the changes around dental implants inserted immediately in maxillary anterior esthetic zone using a novel combination of autogenous demineralized tooth graft. with autogenous demineralized tooth plate and compared this approach to autogenous demineralized tooth graft.
The present study included 63 patients, aged 20 to 45, with teeth that needed to be extracted. After Kafrelsheikh University research ethics committee approval, patients were randomized into 3 groups: group I patients underwent immediate implantation with Duo-Teck membrane, while group II patients underwent the same procedure, but the dehisced bone defect was grafted by autogenous demineralized tooth graft. finally group III was grafted by combination of autogenous demineralized tooth graft. with autogenous demineralized tooth plate. conditions: Implant Complication conditions: Peri-Implantitis conditions: Periodontal Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The present study included 63 participants, aged 20 to 45, with teeth that needed to be extracted. After Kafrelsheikh University research ethics committee approval, patients were randomized into 3 groups: group I patients underwent immediate implantation with duoteck membrane, while group II was grafted by autogenous demineralized tooth graft, but group III was grafted with autogenous demineralized tooth graft with autogenous demineralized tooth plate Clinically, pink aesthetic score (PES), midfacial mucosal alterations (MFMA), stability quotient of dental implants (SQDI) were observed at baseline, six and twelve months after implantation. Moreover, baseline, 6- and 12-months alterations of radiographic horizontal buccolingual ridge width (HBLRW), facial marginal bone level (FMBL), peri-implant Density of bone (PIDB) and peri-implant vertical bone defect depth (PIVBDD) changes were assessed using cone beam computed tomography (CBCT). primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: neither participant nor the outcome assessor know the group distribution whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 63 type: ESTIMATED name: duoteck membrane name: autogenous demineralized tooth graft name: autogenous demineralized tooth graft and plate measure: Stability Quotient of dental implant (SQDI) measure: pink esthetic score (PES) measure: facial marginal bone level (FMBL) sex: ALL minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: faculty of dentistry, kafrelsheikh University status: RECRUITING city: Kafr Ash Shaykh state: Kafrelsheikh zip: 214312 country: Egypt name: Walid elamrousy, PhD role: CONTACT phone: +201091444946 email: perioking1@gmail.com name: Dalia Rasheed Issa, PhD role: CONTACT email: dalia_rasheed@hotmail.com lat: 31.11174 lon: 30.93991 hasResults: False
nctId: NCT06313203 id: 'TOMCAT' SMR-4066 briefTitle: HAI-Floxuridine, or SIRT, Combined With Gemox For Patients With Intra-Hepatic Cholangiocarcinoma Not Amenable to Resection (TOMCAT) acronym: TOMCAT overallStatus: RECRUITING date: 2024-02-13 date: 2031-01 date: 2034-01 date: 2024-03-15 date: 2024-03-15 name: Oslo University Hospital class: OTHER briefSummary: Patients with intrahepatic cholangiocarcinoma (IHC) have relatively aggressive tumors, and the prognosis for most of these patients is dismal. Surgery is the only option that can offer potential cure, but only an estimated 20-25 % are amenable to resection. Down-staging conventional chemotherapy has a relatively low response rate (\< 50 %). Patients will be included into the respective treatment arms based on their tumour characteristics and disease stage, but also based on their ability/preferences, as HAI-FUDR/DEX requires going to Oslo every fortnight for the duration of the treatment and SIRT has some limitations regarding tumour distribution.
Data from the MSKCC has suggested a clinically relevant benefit from adding intrahepatic chemotherapy to systemic therapy. HAI-FUDR/DEX is not approved in Norway and can only be evaluated in a protocolized trial. Given the risk of distant disease progression with IHC, the addition of conventional systemic chemotherapy makes good clinical sense, and data from MSKCC supports this approach. SIRT is another modality also applied trans-arterially and directly into the tumour. This treatment is approved in Norway and available in Bergen and in Oslo. It is far less cumbersome to deliver and maintain than HAI-FUDR/DEX. The efficacy and safety of the two treatment groups, HAI-FUDR/DEX and SIRT, will be compared in a parallel cohort (non-randomized) design conditions: Intrahepatic Cholangiocarcinoma conditions: Chemotherapy Effect studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 800 type: ESTIMATED name: Floxuridine name: Selective Internal Radiation Therapy (SIRT) measure: Overall Survival (OS) at 3 years measure: Tumor response measure: Quality of Life by using EORTC QLQ-C30 measure: Quality of Life by using EQ-5D-5L measure: Assess the resection rate following downstaging measure: Assess complications, toxicity and side effects in treatment groups measure: Assess circulating cell-free (ctDNA) before and after treatment and correlate with treatment outcomes sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Oslo University Hospital status: RECRUITING city: Oslo zip: 0424 country: Norway name: Anne H Longva, MD role: CONTACT phone: 90797458 phoneExt: +47 email: anlong@ous-hf.no name: Kristoffer Lassen, MD PhD role: CONTACT phone: 47616906 phoneExt: +47 email: krlass@ous-hf.no lat: 59.91273 lon: 10.74609 hasResults: False
nctId: NCT06313190 id: SL-B2024-061 briefTitle: Combination of SBRT and Immunotherapy in Small Hepatocellular Carcinoma (HSBRT2402) acronym: HSBRT2402 overallStatus: NOT_YET_RECRUITING date: 2024-04-05 date: 2028-04-30 date: 2030-04-30 date: 2024-03-15 date: 2024-03-15 name: Sun Yat-sen University class: OTHER name: Fifth Affiliated Hospital, Sun Yat-Sen University name: Ningbo Medical Center Lihuili Eastern Hospital briefSummary: For inoperable small hepatocellular carcinoma (HCC), stereotactic body radiotherapy (SBRT) is an effective and safe local treatment. Despite satisfactory local control rate, the incidence of recurrence out the field remains substantial, with 2-year PFS of 31.9% to 60.9%. Therefore, a more effective treatment mode is urgently needed. Immune checkpoint inhibitors targeting PD-1/PD-L1 have shown substantial clinical benefits in advanced HCC as well as resected high-risk HCC. Recently, the combination of immunotherapy with SBRT has shown promising activity in HCC, but its utility in small HCC is unclear. The aim of this study was to investigate the efficacy and safety of SBRT followed by sintilimab (an anti-PD-1 antibody) in patients with recurrent or residual small HCC. conditions: Hepatocellular Carcinoma studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 140 type: ESTIMATED name: Stereotactic body radiotherapy name: Sintilimab measure: Progression-free survival (PFS) rate measure: Overall survival measure: Local control rate (DCR) measure: Treatment-related adverse events measure: Correlation between serum cytokines and overall survival and immune-related adverse events measure: Correlation between ctDNA and overall survival sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sun Yat-sen University Cancer Center city: Guangzhou state: Guangdong zip: 510060 country: China name: Mian Xi, MD role: CONTACT phone: +862087343385 email: ximian@sysucc.org.cn name: Mian Xi, MD role: PRINCIPAL_INVESTIGATOR name: Qi Zeng, MD role: SUB_INVESTIGATOR name: Yi Lu, MD role: SUB_INVESTIGATOR lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06313177 id: Soh-Med-24-03-03MS briefTitle: Syndesmotic Screw in Neutral Position Versus Maximum Ankle Dorsiflexion in Ankle Fractures; Comparative Study. overallStatus: RECRUITING date: 2024-03-10 date: 2025-03-10 date: 2025-03-10 date: 2024-03-15 date: 2024-03-15 name: Sohag University class: OTHER briefSummary: Ankle fracture is one of the most common orthopedic injuries. Approximately, 20% of surgically treated ankle fractures are associated with syndesmotic instability.According to the mechanism of the injury the syndesmotic disruption should be considered in Danis-Weber C-type fractures. However, such injuries were also frequently seen in Danis-Weber B-type fractures. Failure to detect and repair syndesmotic injuries early may result in poor clinical outcomes and complications affecting ankle function, such as long-term residual pain, post traumatic arthritis, and ankle impingement syndromes. Therefore, aggressive treatment is important when facing syndesmotic instability .
The distal tibiofibular syndesmosis is important for stability of the ankle mortise and thus for weight transmission and walking. Syndesmotic injuries are most commonly associated with fibular fractures, but they can also occur in isolation or with damage to the lateral ankle ligament after traumatic supination. The need for syndesmotic fixation of the distal tibiofibular joint has been controversia. fracture does not correlate reliably with the extent of the interosseous membrane tears identified on MRI of ankle fractures, and thus estimation of the integrity of the interosseous membrane and subsequent need for trans-syndesmotic fixation cannot be based solely on the level of the fibular fracture. An intraoperative syndesmotic stress test can establish the presence or absence of syndesmotic instability, evaluating the integrity of the syndesmosis by grasping the stabilised fibula with a hook or clamp and pulling it laterally. If more than 3 or 4 mm of lateral displacement occurs, syndesmotic fixation is necessary.
Most authors recommend surgical placement of a trans-fixation screw after anatomical reduction of the syndesmosis if a disruption is diagnosed to avoid complications.The main aims of treatment for dislocation of the distal tibiofibular syndesmosis are to restore the original anatomy and normal function and to recreate the stability of the ankle joint. The syndesmosis is traditionally fixed with a metallic screw, which is a method that has been used for decades and demonstrates good to excellent outcomes.
Some surgeons prefer Fixation of syndesmosis with screw in maximum ankle dorsiflexion and others prefer fixation in neutral position of ankle.in this study we are going to compare between these two conditions: Syndesmotic Injuries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 40 type: ESTIMATED name: syndesmosis fixation with screws measure: pain with AOFAS score sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sohag university Hospital status: RECRUITING city: Sohag country: Egypt lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06313164 id: SW009 briefTitle: The Impact of Oral Glutathione on Oxidative Damage and Glycated Hemoglobin (HbA1c) Levels in Type 2 Diabetes Patients overallStatus: COMPLETED date: 2023-06-20 date: 2024-01-30 date: 2024-02-29 date: 2024-03-15 date: 2024-03-15 name: S.LAB (SOLOWAYS) class: OTHER name: Center of New Medical Technologies briefSummary: This trial aims to assess the effectiveness of L-glutathione, supplemented with bioavailability boosters (tannin, low molecular weight chitosan, and polyethylene glycol), on improving antioxidant levels and glycemic control in patients with type 2 diabetes (T2D). The study is designed as a randomized, double-blind, placebo-controlled trial intending to enroll 240 T2D patients. The primary objective is to measure changes from baseline to 180 days in several key biomarkers, including endogenous reduced glutathione (GSH), oxidized glutathione (GSSG), 8-hydroxydeoxyguanosine (8-OHdG), and glycated hemoglobin (HbA1c), along with other metabolic parameters.
Hypothesis: The anticipated outcome is a significant increase in GSH levels and a decrease in markers of oxidative damage among participants receiving L-glutathione compared to those in the placebo group, potentially indicating improved antioxidant defenses and some effects on glycemic regulation in T2D patients. This trial aims to fill gaps in current research regarding the role of L-glutathione supplementation in managing oxidative stress and metabolic control in diabetes. conditions: Type 2 Diabetes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 217 type: ACTUAL name: enhanced glutathione name: placebo comparator measure: Reduced glutathione (GSH) levels in erythrocyte hemolysate change in patients with type 2 diabetes mellitus measure: Oxidized Glutathione (GSSG) Levels Change in Patients with Type 2 Diabetes Mellitus measure: 8-Oxoguanine (8-OHdG) Levels Change in Patients with Type 2 Diabetes Mellitus measure: Glycated Hemoglobin Concentration (HbA1c) Change in Patients with Type 2 Diabetes Mellitus measure: Fasting Glucose (FPG) Levels Change in Patients with Type 2 Diabetes Mellitus measure: Postprandial Glucose (PPG) Levels Change in Patients with Type 2 Diabetes Mellitus measure: Fasting Insulin (FPI) Levels Change in Patients with Type 2 Diabetes Mellitus measure: Postprandial Insulin (PPI) Levels Change in Patients with Type 2 Diabetes Mellitus sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Center of New Medical Technologies city: Novosibirsk state: Novosibisk Region zip: 630090 country: Russian Federation lat: 55.0415 lon: 82.9346 hasResults: False
nctId: NCT06313151 id: Soh-Med-24-02-02MD briefTitle: The 2019 EULAR/ACR Classification Criteria as Predictor of Organ Damage in Systemic Lupus Erythematosus Patients overallStatus: RECRUITING date: 2024-03-10 date: 2026-01-15 date: 2026-03-15 date: 2024-03-15 date: 2024-03-15 name: Sohag University class: OTHER briefSummary: The goal of this observational study is to investigate if the 2019 EULAR/ACR classification criteria can be used to assess organ damage in patients with systemic lupus erythematosus (SLE) and as predictor for prognosis . conditions: SLE, and Organ Damage Index studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 200 type: ESTIMATED measure: prediction organ damage in SLE by using 2019 EULAR/ACR classification criteria. sex: ALL minimumAge: 16 Years maximumAge: 60 Years stdAges: CHILD stdAges: ADULT facility: Sohag University status: RECRUITING city: Sohag zip: 82511 country: Egypt name: alyaa A mohamed role: CONTACT phone: 01007218644 email: aliaa.abdelhameed@med.sohag.edu.eg name: mahmoud S allam role: CONTACT phone: 01091103331 email: m.sobhy.allam@gmail.com lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06313138 id: NantongJS briefTitle: Effectiveness of Health Literacy Enhancement Program Among Older Persons With Physical Multimorbidity overallStatus: COMPLETED date: 2023-07-15 date: 2023-12-25 date: 2024-01-30 date: 2024-03-15 date: 2024-03-15 name: Nantong University class: OTHER name: Chiang Mai University briefSummary: The study aims to examine the effectiveness of individual and family health literacy enhancement program among older persons with physical multimorbidity.
Participants in the interventional group will receive the program which is a group-based intervention developed by the researcher based on the Individual and Family Self-Management Theory (IFSMT) (self-management skills) and the principle of Medagogy (PITS model: Pathophysiology, Indications, Treatments, Specifies) to improve patients' and their families' understanding of disease-related information and self-management skills consisting of goal setting and action plan, self-monitoring, solving problems and decision-making, and emotional control.The program will be divided into 8 sessions. Each session will be lasted for 2 hours with 1 intermittent break (10 minutes), and it will be held twice a week, and the last session will be held 1 week after the 7th session. Therefore, it will last for 5 weeks in total. conditions: Multiple Chronic Conditions；Diabetes；Hypertension studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 140 type: ACTUAL name: The Individual and Family Enhancement Program measure: Self-management measure: Treatment burden measure: Symptom burden measure: Health literacy sex: ALL minimumAge: 60 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Nantong University city: Nantong state: Jiang Su zip: 226001 country: China lat: 32.03028 lon: 120.87472 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2022-11-17 uploadDate: 2024-03-08T04:09 filename: ICF_000.pdf size: 3095464 hasResults: False
nctId: NCT06313112 id: JCDC/BHR/23/036 briefTitle: Impact of Food Insecurity on Utilization of Maternal Healthcare Services and Birth Outcomes in Slums in Pune, India overallStatus: RECRUITING date: 2023-09-25 date: 2025-02 date: 2025-02 date: 2024-03-15 date: 2024-03-15 name: Hirabai Cowasji Jehangir Medical Research Institute class: OTHER briefSummary: The goal of this observational study is to assess household food insecurity among slum-dwelling women in India and to explore if household food insecurity is associated with utilization of maternal healthcare services, birth outcomes and infant growth.
* Two focused group discussions (FGDs) will also be conducted to gain insight into the perceptions of these women with respect to the utilization of maternal healthcare services. One FGD will be conducted for women who availed all the healthcare services and the other for those who did not adequately avail of the antenatal and postnatal services. conditions: Prenatal Care conditions: Food Insecurity conditions: Pregnancy Outcome studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 200 type: ESTIMATED name: Observational study measure: Percentage of women who availed at least three Antenatal Care (ANC) visits measure: Percentage of women who had contact with ASHA worker during pregnancy measure: Percentage of women who consumed at least 100 Iron Folic Acid tablets measure: Percentage of women who consumed deworming tablets at least once during pregnancy measure: Percentage of women who underwent delivery preparedness measure: Percentage of women with knowledge of key danger signs during pregnancy measure: Percentage of women who delivered at institution measure: Percentage of women who stayed at a facility for at least 24 hours post-delivery measure: Percentage of women who received post-natal care within a week of delivery measure: Association of demographic characteristics and household food insecurity scores with the indicators of utilization of healthcare services measure: Correlation of indicators of utilization of healthcare services with birth outcomes measure: Correlation of indicators of utilization of healthcare services with infant growth sex: FEMALE minimumAge: 18 Years maximumAge: 49 Years stdAges: ADULT facility: Hirabai Cowasji Jehangir Medical Research Institute status: RECRUITING city: Pune state: Maharashtra zip: 411001 country: India name: Anuradha V. Khadilkar, MBBS,MD role: CONTACT phone: 9850244305 email: anuradhavkhadilkar@gmail.com name: Rubina M. Mandlik, Ph.D. role: CONTACT phone: 9922959588 email: rubymandlik@hotmail.com lat: 18.51957 lon: 73.85535 hasResults: False
nctId: NCT06313099 id: SakaryaAppliedSciencesUPNSC briefTitle: Parameters of the General Health Status of Prison Officers overallStatus: COMPLETED date: 2021-01-01 date: 2021-02-15 date: 2021-03-02 date: 2024-03-15 date: 2024-03-15 name: Pakize Nurgul Sen class: OTHER briefSummary: Introduction The working conditions of prison officers are very stressful. Today, it is known that stress affects the health status of individuals in many ways. In this study, it was aimed to evaluate the musculoskeletal system problems, fatigue severity, depression levels, and quality of life of prison officers and to examine the relationship between these parameters and the socio-demographic characteristics of the participants.
Method The study included a total of 141 volunteers. The musculoskeletal problems of the participants were evaluated with the Cornell Musculoskeletal Disorders Questionnaire, fatigue levels were evaluated with the Fatigue Severity Scale, depression levels were evaluated with the Beck Depression Inventory, and quality of life was evaluated with the Nottingham Health Profile. conditions: Musculoskeletal Pain conditions: Fatigue conditions: Depression conditions: Quality of Life studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 141 type: ACTUAL name: Survey measure: Cornell Musculoskeletal Disorders Questionnaire measure: Fatigue Severity Scale measure: Sleep Quality: Virtual Analog Scala: VAS measure: Beck Depression Inventory measure: Nottingham Health Profile sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Muğla E Type Closed Prison city: Muğla state: Menteşe zip: 48000 country: Turkey lat: 37.21807 lon: 28.3665 hasResults: False