hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06369974 id: 2024P000386 briefTitle: Single Participant Study of an Experimental ASO Treatment for TUBB4A-related Leukodystrophy overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-06 date: 2026-06 date: 2024-04-17 date: 2024-04-18 name: Massachusetts General Hospital class: OTHER name: n-Lorem Foundation briefSummary: This research project entails delivery of a personalized antisense oligonucleotide (ASO) drug designed for a single pediatric participant with TUBB4A associated leukodystrophy. conditions: Genetic Disease studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single participant interventional study primaryPurpose: TREATMENT masking: NONE maskingDescription: Open label study count: 1 type: ESTIMATED name: Antisense oligonucleotide treatment (ASO) measure: Neurological assessments measure: Feeding and swallow evaluation measure: Safety and tolerability sex: ALL minimumAge: 4 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06369961 id: TDFCANCERPAIN20230101 briefTitle: Correlation Between the Analgesic Effect of Fentanyl Transdermal Patches and Nutritional Status in Cancer Pain Patients overallStatus: COMPLETED date: 2023-03-01 date: 2023-07-31 date: 2023-12-31 date: 2024-04-17 date: 2024-04-17 name: Chongqing University Cancer Hospital class: OTHER briefSummary: The goal of this observational study is to investigate the correlation and quantitative relationship between the analgesic effect of fentanyl transdermal patches in cancer pain patients and their nutritional status. conditions: Cancer Pain conditions: Nutrition Disorders studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 151 type: ACTUAL name: transdermal fentanyl measure: 11-point numeric rating scale (NRS) after TDF treatment measure: the occasions that breakthrough pain attacks per day after TDF treatment measure: The dose adjustment of TDF measure: The kinds of other analgesics combined with TDF measure: Adverse effects sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chao Li city: Chongqing zip: 400030 country: China lat: 29.56278 lon: 106.55278 hasResults: False
nctId: NCT06369948 id: M703 briefTitle: Quality Of Recovery After Pericapsular Nerve Group (PENG) Block For Hip Hemiarthroplasty Under Spinal Anesthesia overallStatus: RECRUITING date: 2024-03-01 date: 2024-09-01 date: 2024-09-01 date: 2024-04-17 date: 2024-04-17 name: Fayoum University Hospital class: OTHER briefSummary: Patients undergoing hip hemiarthroplasty can benefit significantly from regional anesthesia in terms of pain management and recovery . There is a wide range of regional anesthetic techniques. The most common in this anatomical region and those with the greatest published research are fascia iliac block, lumbar plexus block, and femoral nerve block . Alternative methods include lateral femoral cutaneous nerve and selective obturator nerve infiltration blocks. Novel techniques, including local infiltration analgesia and quadratus lumborum block, have been reported.
While femoral nerve and lumbar plexus blocks are two common opioid-sparing regional anesthetic procedures that are successful, they come with a risk of undesired lower limb muscle weakness . On the other hand, the fascia iliac block does not always offer sufficient pain relief following hip surgery. The important landmarks targeted on the hip joint branches from the femoral nerve and the auxiliary obturator nerve may now be identified thanks to a recent anatomical study on hip innervation .
This led to the discovery of a novel localized anesthetic treatment termed pericapsular nerve group block (PENG), which blocks these nerves to target the hip's anterior capsule. The PENG block has been suggested as a successful motor-sparing block for hip hemiarthroplasty . The objective of the current study is to evaluate the efficacy of the pericapsular nerve group block (PENG) for the reduction of opioid consumption and management of postoperative pain after hip hemiarthroplasty. conditions: Hip Hemiarthroplasty studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: We will include 60 patients who will undergoe elective hip hemiarthroplasty. Patients will be divided into two groups randomized by computer generated random numbers that will be placed in separate opaque envelopes that will be opened by study investigators just before the block.
Control group (C group) includes 30 patients who will not receive a PENG block. primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Patients will be divided into two groups randomized by computer generated random numbers that will be placed in separate opaque envelopes that will be opened by study investigators just before the block. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Pericapsular Nerve Group (PENG) Block name: elective hip hemiarthroplasty without receiving a PENG block. name: bupivacaine 0.5% injection measure: Total opioid consumption post operative measure: 2) a Visual Analogue Scale (VAS) ranging from zero (no pain) to 10 (severe pain) for dynamic and static pain measure: 3) Time to first opioid use measure: 4) Ability to perform physiotherapy measure: 5) Opioid-related side effects. measure: 6) Total length stay of hospital measure: 7) Complications of local anesthetic toxicity sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fayoum University Hospital status: RECRUITING city: Madīnat Al Fayyūm state: Fayoum Governorate zip: 63514 country: Egypt name: Atef Mohamed Sayed, MS.C role: CONTACT phone: 01003973883 email: amk04@fayoum.edu.eg lat: 29.31667 lon: 30.83333 hasResults: False
nctId: NCT06369935 id: 20240407 briefTitle: A Real World Study of Equecabtagene Autoleucel in Subjects With Relapsed and Refractory Multiple Myeloma. overallStatus: NOT_YET_RECRUITING date: 2024-06-20 date: 2026-08-20 date: 2027-08-20 date: 2024-04-17 date: 2024-04-17 name: Peking University People's Hospital class: OTHER briefSummary: This study is a multicenter, observational, single-arm real world study. The purpose of this study is to describe demographic and disease characteristics, treatment patterns, and clinical outcomes in the real-world setting among participants in China with relapsed/refractory multiple myeloma (RRMM) who have been treated with Equecabtagene Autoleucel. This study will use both prospective and retrospective data conditions: Relapsed/Refractory Multiple Myeloma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 260 type: ESTIMATED name: Equecabtagene Autoleucel measure: Best Overall Response Rate， BOR measure: PFS rate of 6 month measure: OS rate of 6 month measure: Time to Response， TTR measure: Time to Complete Response， TTCR measure: Adverse Event， AE sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking University People's Hospital city: Beijing country: China name: Yang Liu role: CONTACT phone: +8613716926210 email: pkuphliuyang@bjmu.edu.cn lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06369922 id: STUDY00009315 briefTitle: TENS Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence. acronym: TENSUB overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2026-03-31 date: 2026-06-01 date: 2024-04-17 date: 2024-04-19 name: University of Rochester class: OTHER briefSummary: This will be a double-blind randomized control trial in women with stress urinary incontinence who are undergoing an outpatient transurethral bulking procedure for stress urinary incontinence. Subjects will be identified by the University of Rochester urologists and urogynecologists participating in the study who currently oversee stress incontinence care. Subjects will be randomized into two groups. One group will be undergoing the cystoscopy with transcutaneous electrical nerve stimulation (TENS) for analgesia, and the second group will have the cystoscopy with placebo TENS. conditions: Stress Incontinence Female conditions: Urinary Incontinence conditions: Urinary Incontinence,Stress conditions: Pain conditions: Pain Acute studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: TENS name: Control TENS measure: Mean pain measured by Visual Analog Scale (VAS) measure: Mean pain measured by Visual Analog Scale (VAS) measure: Mean pain measured by Visual Analog Scale (VAS) measure: Mean pain measured by Likert scale measure: Mean pain measured by Likert scale measure: Mean pain measured by Likert scale measure: Number of participants with side effects measure: Mean satisfaction with the procedure measure: TENS or NO TENS sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pelvic Health and Continence Specialties city: Rochester state: New York zip: 14623 country: United States name: Jared M Floch, DO, MS role: CONTACT phone: 585-895-9301 email: jared_floch@urmc.rochester.edu name: Diego Hernandez-Aranda, MD role: CONTACT phone: (585) 487-3400 email: diego_hernandezaranda@urmc.rochester.edu name: Jared M Floch, DO, MS role: PRINCIPAL_INVESTIGATOR lat: 43.15478 lon: -77.61556 hasResults: False
nctId: NCT06369909 id: K5507 briefTitle: Study on AI-assisted Multimodal Diagnosis System of Autoimmune Pancreatitis overallStatus: RECRUITING date: 2024-01-31 date: 2025-01-31 date: 2026-01-31 date: 2024-04-17 date: 2024-04-17 name: Peking Union Medical College Hospital class: OTHER name: Tianjin Medical University General Hospital name: The Second Hospital of Hebei Medical University briefSummary: The existing comprehensive diagnostic system for autoimmune pancreatitis (AIP) is complex, with multidimensional clinical information including morphological changes and a lack of specific biomarkers. Endoscopic ultrasound (EUS) can provide all the elements for morphological diagnosis of AIP, but the long learning curve and large observer differences make it difficult to popularize and promote. The cooperation units of the three regions in this project have found in the early stage that Klebsiella pneumoniae (KP) induced follicular helper T cells (Tfh) activation is an important mechanism of AIP, but the identification of pathogenic components of the strain and clinical validation need to be explored. We have established a national multicenter AIP queue in the early stage and extracted EUS audio-visual features to establish a scoring model, but intelligent assistance is still needed to improve efficiency. Therefore, we plan to integrate gut microbiota, Tfh activation markers, and EUS imaging features to establish an AI assisted multimodal diagnostic system for AIP. This study will collaborate across multiple centers to identify and validate the components that induce Tfh activation in KP bacterial cells, to extract EUS pancreatic ultrasound features and optimize artificial intelligence assisted diagnostic algorithms, and to establish and validate an artificial intelligence assisted multimodal diagnostic system based on clinical information, biomarkers, and EUS. The aim of this study is to provide new diagnosis and treatment evaluation methods for AIP with high accuracy, convenience, and easy promotion for clinical practice. conditions: Autoimmune Pancreatitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 180 type: ESTIMATED name: EUS-FNA measure: Tfh level in blood measure: Microbiota composition measured by 16S rRNA sequencing measure: AI-EUS differentiation measure: Cytokine level in blood sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences status: RECRUITING city: Beijing state: Beijing zip: 100730 country: China name: Mai Li role: CONTACT phone: 13683296860 email: pumchkyc@126.com name: Xi Wu role: PRINCIPAL_INVESTIGATOR lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06369896 id: SpyIDUSForNonictericStricture briefTitle: Digital Single-operator Cholangioscopy and Intraductal Ultrasound for Nonicteric Biliary Strictures acronym: Spy+IDUS overallStatus: NOT_YET_RECRUITING date: 2024-05-05 date: 2025-12-25 date: 2026-12-25 date: 2024-04-17 date: 2024-04-17 name: Soonchunhyang University Hospital class: OTHER briefSummary: This study aims to evaluate the usefulness of disposable digital single-operator cholangioscopy (SOC) and intraductal ultrasound (IDUS) for the accurate diagnosis of indeterminate biliary stricture. conditions: Cholangiocarcinoma conditions: Biliary Stricture studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 36 type: ESTIMATED measure: diagnostic accuracy of SOC measure: Diagnostic accuracy of IDUS measure: Technical success of SOC measure: Technical success of IDUS measure: Adverse event sex: ALL minimumAge: 19 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06369883 id: 2022/41 briefTitle: How Often and What Type of Deformity is Detected in All Spine Radiographs? overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-06-30 date: 2024-08-30 date: 2024-04-17 date: 2024-04-17 name: Bakirkoy Dr. Sadi Konuk Research and Training Hospital class: OTHER_GOV briefSummary: The study will be done retrospectively.The aim of this study is to retrospectively examine the spinal pathologies of patients with a prediagnosis of spinal deformity and for whom spinal radiography is requested and to evaluate the clinical features of these patients. conditions: Scoliosis conditions: Kyphosis conditions: Radiography studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: RETROSPECTIVE count: 632 type: ESTIMATED name: Spine radiography measure: Who should have full spine radiographs? measure: We aimed to determine the frequency of kyphosis, types and percentages of scoliosis detected on the radiographs. sex: ALL minimumAge: 1 Year maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06369870 id: PAINCARE briefTitle: Interpectoral-pectoserratus Plane Block for Minimally Invasive Aortic Valve Replacement Via Right Anterior Minithoracotomy acronym: PAINCARE overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2027-11 date: 2027-12 date: 2024-04-17 date: 2024-04-17 name: Algemeen Ziekenhuis Maria Middelares class: OTHER briefSummary: The goal of this clinical trial is to evaluate the analgesic effect of locoregional anaesthesia, specifically the interpectoral pectoserratus plane (IPP-PSP) block, in comparison to a placebo (sham block) after Aortic Valve Replacement via Right Anterior Minithoracotomy (AVR-RAT). The main question the trial aims to answer is: Can the IPP-PSP block effectively reduce opioid consumption within the first 48 hours after AVR-RAT surgery? The purpose is to understand the impact of the IPP-PSP block on postoperative pain. Therefore, the aim is to investigate the influence of the IPP-PSP block on the amount of pain medication administered during the patients' first 48 hours after surgery.
Patients will be monitored during their hospitalization, and a follow-up phone call will be conducted 30 days after surgery. conditions: Analgesic Effect studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The trial is designed as a single-center, prospective, double-blind, randomized controlled superiority trial. Patients will be randomly assigned to either the IPP-PSP block group or the sham block group (placebo). primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Neither the participant, anesthesiologist, study nurse, surgeon, nor the doctors and nurses in the Intensive Care Unit will know the participant's group assignment. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 144 type: ESTIMATED name: Levobupivacaine Hydrochloride 0.25 % Injectable Solution name: Sodium chloride 0.9% measure: Cumulative opioid consumption measure: Number of episodes of postoperative pain measure: Time to need for rescue medication measure: Number of patients with respiratory complications measure: PaCO2 levels measure: Postsurgical Quality of Recovery measured by the Quality of Recovery questionnaire measure: Number of episodes of postoperative nausea and vomiting measure: Time to extubation measure: Number of hours spent in the Intensive Care Unit measure: Hospitalization duration measure: Quality of life measured by the 5 level version of the EuroQoL-5 Dimension questionnaire measure: Days alive and at home measure: Vital status (whether the patient is alive or dead) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bart Vaes city: Gent state: Oost-Vlaanderen zip: 9000 country: Belgium name: Bart Vaes, MD role: CONTACT phone: +3292461700 email: bart.vaes@mijnziekenhuis.be name: Steffi Ryckaert, MSc role: CONTACT phone: +3292461910 email: steffi.ryckaert@mijnziekenhuis.be lat: 51.05 lon: 3.71667 hasResults: False
nctId: NCT06369857 id: PPY briefTitle: Pectopexy for Apical Prolapse Management overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-02 date: 2025-08 date: 2024-04-17 date: 2024-04-17 name: Assiut University class: OTHER briefSummary: This study was designed to evaluate the efficacy of pectopexy for treatment of apical pelvic organ prolapse at follow up at 12 months. Investigator also evaluates complications, improvement of symptoms, quality-of-life outcomes and patient satisfaction with surgery.
Assessment of restoration of normal pelvic anatomy and lower urinary tract symptoms using transperineal ultrasound conditions: Pelvic Organ Prolapse studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Case series study primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: Pectopexy measure: Pelvic Organ Prolapse Quantification stage measure: Urinary Symptoms questionnaire measure: Bladder neck measurements using Transperineal US sex: FEMALE minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06369844 id: 1.2023-440 briefTitle: Pressure Injury Education Intervention for Pediatric Intensive Care Nurses: A Randomized Controlled Trial overallStatus: ENROLLING_BY_INVITATION date: 2024-04-01 date: 2024-04-03 date: 2024-04-30 date: 2024-04-17 date: 2024-04-17 name: Ankara Yildirim Beyazıt University class: OTHER name: Ankara City Hospital Bilkent briefSummary: The purpose of this observational study is to find out the impact of pressure injury education on the knowledge level of pediatric intensive care nurses and the likelihood of pediatric pressure injury occurrence. The main questions it aims to answer are:
* Two weeks after the completion of the education sessions, all nurses in the intervention and control groups who wish to continue participating in the study will answer the pressure injury survey questions prepared by the researcher again. conditions: Pressure Injury Prevention studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study design will be two-group and pretest-posttest design. primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 50 type: ESTIMATED name: Pressure injury education measure: Stop Pressure Injuries" Education Evaluation Survey sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ankara yıldırım Beyazıt Üniversitesi city: Ankara country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06369831 id: ABS011-1 id: 2024-511419-22-00 type: CTIS briefTitle: HER2 Targeted Molecular Imaging in mBC Using 68Ga-ABS011 acronym: HERMIA overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-01 date: 2025-06 date: 2024-04-17 date: 2024-04-17 name: ABSCINT NV/SA class: INDUSTRY briefSummary: This phase II study aims to confirm the diagnostic performance and accuracy of 68Ga-ABS011 PET/CT in determining the HER2 expression status, and to evaluate 68Ga-ABS011's ability to drive changes in therapeutic treatment. 68Ga-ABS011 will be compared to the current standard of care (SOCa) diagnostic methods including immunohistochemistry (IHC), in situ hybridization (ISH) and imaging tools used for treatment response follow-up including Fluorodeoxyglucose F-18 (18F-FDG) positron emitted tomography (PET) and contrast enhanced computed tomography (ceCT). conditions: Metastatic Breast Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Interventional, prospective, single arm radio-diagnostic study. Driven by number of biopsied lesions (and not by number of patients) primaryPurpose: DIAGNOSTIC masking: NONE count: 60 type: ESTIMATED name: 68Ga-NOTA-ABSCINT-HER2 PET/CT measure: positive, negative, and overall diagnostic agreement between 68Ga-ABS011 PET/CT and the standard of care IHC (and ISH) HER2 status test. measure: Safety of 68Ga-ABS011. measure: Change in treatment management measure: reliability of whole body 68Ga-ABS011 PET/CT compared to HER2-targeted treatment response (Early tumor shrinkage) measure: reliability of whole body 68Ga-ABS011 PET/CT compared to HER2-targeted treatment response (metabolic response) measure: Tumor heterogeneity sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: OLV Aalst city: Aalst state: East-Flanders zip: 9300 country: Belgium name: G. Huygh, Dr. role: CONTACT lat: 50.93604 lon: 4.0355 facility: AZ Delta city: Brussels zip: 1070 country: Belgium name: C. Closset, Dr. role: CONTACT lat: 50.85045 lon: 4.34878 facility: Cliniques Universitaires Saint-Luc city: Brussels zip: 1070 country: Belgium name: F. Duhoux, Prof. role: CONTACT lat: 50.85045 lon: 4.34878 facility: Free University Brussels (VUB) city: Brussels zip: 1070 country: Belgium name: C. Fontaine, Dr. role: CONTACT lat: 50.85045 lon: 4.34878 facility: Institut Jules Bordet city: Brussels zip: 1070 country: Belgium name: E. De Azambuja, Prof. role: CONTACT lat: 50.85045 lon: 4.34878 hasResults: False
nctId: NCT06369818 id: AnIt23-02 briefTitle: Correlation of Cardiac Output Determined by Echocardiography and Indirect Calorimetry in Critically Ill Patients in Cardiogenic Shock on Extracorporeal Circulatory Life Support overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-09 date: 2027-02 date: 2024-04-17 date: 2024-04-17 name: Universität Münster class: OTHER briefSummary: This observational study investigates whether the daily measured trend of cardiac output as evaluated by indirect calorimetry correlates with the same evaluated by transthoracic echocardiography. conditions: Cardiogenic Shock studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED measure: Correlation of t two methods of determining cardiac output (determined by transthoracic echocardiography and determined by indirect calorimetry sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Münster city: Münster zip: 48149 country: Germany name: Thilo von Groote, MD role: CONTACT phone: +49-251-47255 lat: 51.96236 lon: 7.62571 hasResults: False