hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06266767 id: MRC-01-18-157 briefTitle: Programmed Intermittent Epidural Bolus (PIEB) Techniques for Labour Analgesia acronym: PIEB overallStatus: NOT_YET_RECRUITING date: 2024-02-20 date: 2024-04-20 date: 2024-04-30 date: 2024-02-20 date: 2024-02-20 name: Hamad Medical Corporation class: INDUSTRY briefSummary: Epidural Analgesia remains the most effective form of pain relief in labour. After initiating epidural analgesia, there are many epidural drug regimens that can be employed to maintain analgesia for the duration of labour using an epidural catheter. Due to recent advances in medical technology, new epidural pumps, which allow both patient controlled epidural analgesia boluses (PCEA, a common standard of care in many hospitals) and programmed intermittent epidural boluses (PIEB, automatic boluses given in addition to the PCEA bolus), are now available. In this randomized double-blind trial, we aim to evaluate the effects of different combinations of PIEB (epidural bolus volume) and PIEB (bolus volume and time interval) on labour patient-controlled epidural analgesia (PCEA) usage. In theory, the more effective the PIEB combination (the ideal drug volume and ideal time interval), the less PCEA boluses (extra epidural drug) will be used as well as less clinician boluses and less lower limb weakness (motor block) as assessed by the Bromage Score. conditions: Labor Pain conditions: Obstetric Pain conditions: Analgesia studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: We aim to use a pragmatic sequential optimization method as described by Sveticic et al. 2003. For the first round of recruitment, the research team will randomize women into 8 different groups of PIEB/PCEA regimens with six (n=6) women per group and set up the epidural pump for the maintenance of labor analgesia. This first round of recruitment will be called Complex #1. The PCEA bolus volume and lockout interval will stay the same for all groups.
There will be 8 combinations of PIEB/PCEA using an epidural mixture of 0.1% levobupivacaine + 2mcg/ml Fentanyl (n=48). We will exclude the 2 worst performing groups (as assessed by our composite primary outcome). Using sequential optimization, 2 new groups with different combinations of PIEB volume / interval will be added to the remaining 6 groups. Complex 2 therefore will consist of 8 groups of 48 patients (n=6 per group). We anticipate 3 to 4 rounds of recruitment until our statistician determines the 2 best performing groups. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: TRIPLE maskingDescription: This is a randomized double-blinded design. Patients and their attending physicians / clinical anaesthetists / data collection study member / midwives / nurses will be blinded to patient group allocation whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 200 type: ESTIMATED name: Levobupivacaine and Fentanyl measure: The volume of local anaesthetic mixture for breakthrough pain (PCEA + clinician bolus) + the Bromage Score measure: Pain score measure: Total local anesthetic consumption measure: Need for supplementary epidural analgesia measure: Bromage score (lower limb weakness score) measure: Type of delivery measure: Sensory block measure: Fetal Outcome sex: FEMALE minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Hamad Medical Corporation (HMC) city: Doha zip: 3050 country: Qatar lat: 25.28545 lon: 51.53096 hasResults: False
nctId: NCT06266754 id: OPV-IMMUNO-ADULT briefTitle: The Non-Specific Immunological Effects of Providing Oral Polio Vaccine to Seniors in Guinea-Bissau overallStatus: ENROLLING_BY_INVITATION date: 2024-01-29 date: 2024-07-31 date: 2024-12-31 date: 2024-02-20 date: 2024-02-20 name: Bandim Health Project class: OTHER name: Radboud University Medical Center briefSummary: OPV is the live attenuated vaccine against polio virus. OPV has been key in almost eradicating polio infection. Intriguingly, OPV has been associated with lower all-cause mortality and morbidity. These beneficial OPV effects were seen in contexts with no circulating polio virus and thus have nothing to do with the specific effects of OPV against polio infection. They have been coined "non-specific effects" (NSEs). Such NSEs have also been observed for other live attenuated vaccines such as BCG vaccine and measles vaccine. The underlying immunological mechanisms are unknown. Other live vaccines with beneficial NSEs have been shown to induce epigenetic changes leading to "trained immunity". They have also been associated with decreased inflammation. In the present study it will be investigates whether OPV can induce trained immunity, reduce inflammation, and induce epigenetic modifications of the innate immune cells in senior citizens in Guinea-Bissau. conditions: Vaccine Reaction studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomised trial primaryPurpose: PREVENTION masking: DOUBLE maskingDescription: A placebo will be used. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Oral polio vaccine name: Placebo measure: Levels of in vitro proinflammatory cytokines such as IL1-beta, TNF-alfa and IFN-gamma after stimulation of peripheral blood mononuclear cells with non-OPV antigens and mitogens measure: Levels of plasma markers of systemic inflammation such as TNF ligand superfamily member 12 (TWEAK) and sirtuin 2 (SIRT2) measure: Amount of pseudo-bulk ATACseq and RNAseq - indicating chromatin accessibility of interferon-stimulated genes associated with the interferon response pathway in PBMCs. measure: Proportions of immune cell subsets sex: MALE minimumAge: 50 Years maximumAge: 120 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bandim Health Project, Apartado 861 city: Bissau country: Guinea-Bissau lat: 11.86357 lon: -15.59767 hasResults: False
nctId: NCT06266741 id: NCT093509350936 briefTitle: The Predictive Value of Lubricin in Patients With Infective Endocarditis overallStatus: ENROLLING_BY_INVITATION date: 2024-02-11 date: 2024-02-20 date: 2026-02-20 date: 2024-02-20 date: 2024-02-20 name: Aydin Adnan Menderes University class: OTHER briefSummary: The main goal of this study is to evaluate the predictability of the disease by measuring the serum lubricin levels in patients with infective endocarditis and in non-patients conditions: Infective Endocarditis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: Lubricin measure: Valve damage indicative sign in infective endocarditis sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sevil Gulasti city: Aydın state: Zafer zip: 09010 country: Turkey lat: 37.84501 lon: 27.83963 hasResults: False
nctId: NCT06266728 id: IRB00006733 briefTitle: T30 for Astigmatism in Digital Device Users acronym: T30FA overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-15 date: 2024-08-15 date: 2024-08-18 date: 2024-02-20 date: 2024-04-22 name: Southern College of Optometry class: OTHER name: Alcon Research briefSummary: This study aims to determine if Total30 lenses for astigmatism can be successfully fit in participants who are heavy digital device users. conditions: Contact Lens Complication conditions: Astigmatism conditions: Refractive Errors studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This prospective, one-month, three-visit study will refit all participants into TOTAL30 for Astigmatism contact lenses. primaryPurpose: TREATMENT masking: NONE count: 48 type: ESTIMATED name: Total30 for Astigmatism Contact Lenses measure: Visual Analog Scale (VAS) Comfort Scores sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Kannar Eye Care city: Pittsburg state: Kansas zip: 66762 country: United States lat: 37.41088 lon: -94.70496 facility: Coldwater VIsion Center city: Coldwater state: Mississippi zip: 38618 country: United States lat: 32.71486 lon: -89.21423 hasResults: False
nctId: NCT06266715 id: NFEC-2024-070 briefTitle: Improvement of Depression With Use of ATP overallStatus: RECRUITING date: 2024-03-04 date: 2026-12-31 date: 2026-12-31 date: 2024-02-20 date: 2024-03-19 name: Nanfang Hospital, Southern Medical University class: OTHER briefSummary: This clinical study is a randomized, double-blind, placebo-controlled trial with an intervention period of 4 weeks. Participants will be patients with moderate to severe depression who meet the inclusion criteria during the screening period. After recruitment written informed consent form will be signed and the baseline evaluation will be done then the treatment period follows. The subjects will be randomly assigned to a control group (escitalopram plus normal saline(NA)) and an ATP group (escitalopram plus adenosine disodium triphosphate(ATP)) in a 1:1 ratio for treatment, with a total number of 120 recruited patients. Assessment will be carried out as an analysis of changes in Hamilton Depression Scale（HAMD-24）, cognitive function test, brain functional network, inflammatory markers, and other indicators in the first, second, and fourth week of intervention which will evaluate the effectiveness of ATP in improving moderate to severe depression preliminarily. conditions: Depression studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: ATP Group name: Placebo Group measure: HAMD-24 measure: Diffusion Tensor Imaging measure: Diffusion Spectral Imaging measure: Quantitative susceptibility mapping measure: Monetary Incentive Delay Task measure: Emotional faces processing task measure: Resting state functional connectivity measure: Hamilton Anxiety Scale measure: Clinical Global Impression measure: Snaith-Hamilton Pleasure Scale measure: Insomnia Severity Index measure: Columbia-Suicide Severity Rating Scale measure: Antidepressants Side Effects measure: C-reactive protein measure: Tumor Necrosis Factor α measure: Interleukin- 6 measure: N-back task measure: Attention network test measure: Psychomotor vigilance task measure: Hamilton Depression Scale measure: Montgomery and asberg Depression Rating Scale measure: Beck Depression Inventory sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Nanfang Hospital, Southern Medical University status: RECRUITING city: Guangzhou state: Guangdong zip: 510515 country: China name: Qianqian Xin role: CONTACT phone: 17664175246 email: xinqianqian0126@163.com lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06266702 id: BL71 briefTitle: Evaluation of a Nutritional Technology for Vitamin D Absorption overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-06 date: 2024-06 date: 2024-02-20 date: 2024-02-20 name: Abbott Nutrition class: INDUSTRY briefSummary: This is a prospective, 2-group crossover, randomized, double-blind study to evaluate nutrient absorption. conditions: Nutrition, Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 32 type: ESTIMATED name: Experimental Oil with Phospholipids name: Control Polyunsaturated Oil Blend measure: Vitamin D Absorption measure: Vitamin D Absorption - Peak measure: Vitamin D Absorption - AUC measure: Body Mass Index measure: Adverse Events sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Walsh University city: North Canton state: Ohio zip: 44720 country: United States lat: 40.87589 lon: -81.40234 hasResults: False
nctId: NCT06266689 id: Pro00112671 briefTitle: Project humAn dieTary daTa rEtuRN acronym: PATTERN overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-12 date: 2025-12 date: 2024-02-20 date: 2024-02-20 name: Duke University class: OTHER briefSummary: This study is designed to test the effects of diet data return on human dietary patterns. The investigators' working hypothesis is that returning diet data, collected via an empirical biomarker-based assessment method, will promote participant eating behavior changes towards a more healthful diet, and that these dietary patterns may also be reflected in the structure and function of the gut microbiome and in participant health outcomes. Here, the investigators will explore this hypothesis with participants supplying stool (poop) samples that will be used to assess their diet using the investigators' DNA-biomarker based method. Participants will have their diet data returned to them, and will then supply post-intervention stool samples for dietary assessment to investigate the efficacy of diet data return in impacting subject dietary patterns and health. It is anticipated that the investigators will enroll infants, children, and adults across the age span, including infants that are currently participating in Project HOPE 1000, a longitudinal observational study of mothers and infants from pregnancy through early childhood (Pro00100000). This study represents a minimal risk to subjects; namely, the potential loss of privacy involved with study participation. conditions: Diet Habit studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 600 type: ESTIMATED name: Personalized Diet Information measure: Number of participants with diet improvement measure: Number of participants with increased dietary diversity measure: Number of participants with changes in the composition and function of the gut microbiome sex: ALL maximumAge: 12 Months stdAges: CHILD hasResults: False
nctId: NCT06266676 id: 202301775B1 briefTitle: Mobile Micro-course Impact on Perioperative RNs in Heart Surgery Nursing. overallStatus: RECRUITING date: 2024-02-01 date: 2024-04-10 date: 2024-12-31 date: 2024-02-20 date: 2024-02-20 name: Ting-Fang Yeh class: OTHER briefSummary: The goal of this clinical trialis to compare in learning effectiveness of nurses. The main questions it aims to answer are:
Participants will be divided into two groups. The control group will receive online presentations, while the experimental group will engage in mobile learning combined with micro-courses. Both groups of participants will undergo instruction through asynchronous online courses. conditions: periOperative conditions: Cardiac Surgical Procedures studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE whoMasked: PARTICIPANT count: 75 type: ESTIMATED name: micro-course name: slide presentation measure: Cognitive scale measure: motivation scale measure: Engagement Scale measure: learning satisfaction sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: ChangGungMH status: RECRUITING city: Taoyuan City zip: 33305 country: Taiwan name: Ting-Fang Yeh role: CONTACT phone: +88633281200 phoneExt: 2380 email: ytf812@cgmh.org.tw lat: 24.95233 lon: 121.20193 hasResults: False
nctId: NCT06266663 id: 2022-13788 id: CNTO1275IBD4012 type: OTHER domain: Janssen Scientific Affairs, LLC briefTitle: Social Determinants of Health, Medication Use, and Quality of Life in Inflammatory Bowel Disease overallStatus: RECRUITING date: 2024-04 date: 2024-12 date: 2024-12 date: 2024-02-20 date: 2024-03-04 name: Montefiore Medical Center class: OTHER name: Icahn School of Medicine at Mount Sinai name: Janssen Scientific Affairs, LLC briefSummary: Optimizing health related-quality of life (HRQoL) for patients with inflammatory bowel disease (IBD), who often experience a relapsing disease course, is an essential component of care. Improving IBD disease control is linked to increased health-related quality of life. Even as many effective pharmacotherapies to promote disease control are available, evidence suggests that Hispanic and Non-Hispanic Black IBD patients may not receive full benefit from these therapies compared to their Non-Hispanic White counterparts. Underlying mechanisms that contribute to observed disparities in the use of IBD medical therapies are likely multifactorial. Adequate access to treatment has been implicated. Hispanic and Non-Hispanic Black IBD patients are more likely to be Medicaid-insured, and Medicaid insurance has been associated with increased emergency room visits, a proxy for sub-optimal IBD control. Medication adherence has also been proposed as a potential mediating factor. IBD therapies can be time-consuming and costly, which can pose a challenge in achieving medication adherence. While previous studies suggest Black IBD patients have lower medication adherence than Non-Hispanic White patients, it is unclear the extent to which social factors contribute to this observation. The purpose of this study is to evaluate the association between social determinants of health, medication adherence, and HRQoL among Hispanic and Non-Hispanic Black IBD patients. Understanding potentially modifiable psychosocial factors that contribute to medication adherence and HRQoL will provide targets for later intervention towards the goal of health equity. conditions: Inflammatory Bowel Diseases studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 400 type: ESTIMATED name: Survey measure: IBD medication adherence measure: Health-related quality of life (HRQoL) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Montefiore Hutchinson Campus status: RECRUITING city: Bronx state: New York zip: 10461 country: United States name: Ruby Greywoode, MD role: CONTACT phone: 347-671-8205 email: rgreywoode@montefiore.org name: Sheila Benitez role: CONTACT phone: 347-429-0253 email: sheila.benitez@einsteinmed.edu lat: 40.84985 lon: -73.86641 facility: Icahn School of Medicine at Mount Sinai status: NOT_YET_RECRUITING city: New York state: New York zip: 10029 country: United States name: Zoe Gottlieb, MD role: CONTACT email: Zoe.Gottlieb@mountsinai.org lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06266650 id: 19485 briefTitle: Unilateral vs Bilateral Application of Muscle Energy Techniques in Pelvic Somatic Dysfunction acronym: PMEOMT overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-08-30 date: 2024-09-30 date: 2024-02-20 date: 2024-02-20 name: The Touro College and University System class: OTHER briefSummary: The goal of this clinical trial is to compare the efficacy of pelvic muscle energy technique online against the traditional full length osteopathic pelvic treatment protocol. The main question it aims to answer are
Subjects diagnosed with pelvic SD will be divided into two groups. One group will be treated with traditional one and be compared with the pelvic muscle energy group. conditions: Pelvic Somatic Dysfunction studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Subjects diagnosed with pelvic SD will be divided into two groups. One group will be treated with traditional one-sided MET, the second group will be treated with combination MET. Results of post-treatment exams will be collected and statistically analyzed. primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Osteopathic Treatment Technique- Muscle Energy Treatment measure: Resolution of pelvic somatic dysfunction measure: Anterior anatomical landmarks assessment measure: Posterior anatomical landmarks assessment sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06266637 id: P.T.REC/012/004999 briefTitle: Effect of Scoliosis-Specific Exercise on Lower Limb Biomechanics overallStatus: ACTIVE_NOT_RECRUITING date: 2023-03-12 date: 2024-03-01 date: 2024-03-15 date: 2024-02-20 date: 2024-02-20 name: Delta University for Science and Technology class: OTHER name: Benha University briefSummary: PURPOSE: To examine the effect of Physiotherapeutic Scoliosis-Specific Exercise on limb biomechanical parameters in adolescents with idiopathic scoliosis. A randomised controlled trial
Adolescent idiopathic scoliosis is one of the most common orthopaedic diseases affecting the spine during adolescence. The efficacy of exercise treatment is controversial. Although evidence suggests that PSSE, which include auto-correction in 3D, integration in daily life, stabilizing the corrected posture, and patient education, could improve some outcomes, effect of PSSE on related biomechanical alterations in lower limbs have not yet been examined.
What are the effect of Physiotherapeutic Scoliosis-Specific Exercise on lower limb biomechanics in scoliotic adolescents.? conditions: Scoliosis Idiopathic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 56 type: ACTUAL name: Conventional Physical Therapy Program name: Physiotherapeutic Scoliosis-Specific Exercise (Schroth) measure: Cobb's angle measure: Coronal balance measure: length of the the tibia and femur measure: tibiofemoral angle measure: knee joint line convergence angle measure: lower limb mechanical axis; and mechanical axis deviation sex: ALL minimumAge: 10 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Delta university for science and technology city: Gamasa state: Dakahleya zip: 7731168 country: Egypt lat: 31.44112 lon: 31.53675 hasResults: False
nctId: NCT06266624 id: Tourniquet in HHT briefTitle: Tourniquet-Test in HHT overallStatus: ACTIVE_NOT_RECRUITING date: 2020-09-25 date: 2023-07-30 date: 2024-07-30 date: 2024-02-20 date: 2024-02-20 name: University Hospital, Essen class: OTHER briefSummary: The Tourniquet test is used as a diagnostic procedure for thrombocytopathies and vascular diseases. Currently, there is no evidence whether this test is also positive in hereditary haemorrhagic telangiectasia (HHT), a vasculopathy. The aim of this study was to investigate whether this non-invasive test could also be used as an additional diagnostic criterion in patients with HHT. conditions: HHT studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 92 type: ACTUAL name: Tourniquet Test measure: number of positive Tourniquet Test results in HHT patients sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Essen city: Essen state: Nordrhein Westphalen zip: 45122 country: Germany lat: 51.45657 lon: 7.01228 hasResults: False