Primary outcome is PFS. Secondary endpoints include grade ≥3 toxicity, QoL, physical functioning, overall survival, number of treatment cycles, dose reductions, hospital admissions, cumulative received dosage and cost-effectiveness. conditions: Older Patients conditions: Colorectal Cancer conditions: Metastatic Cancer conditions: Candidates for Palliative Chemotherapy studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A phase III, open-label, non-inferiority, randomized controlled clinical trial comparing dose-reduced chemotherapy versus standard dose chemotherapy in older adults with metastasized colorectal cancer primaryPurpose: TREATMENT masking: NONE count: 587 type: ESTIMATED name: Doublet Chemotherapy, Standard Dose (100%) name: Doublet Chemotherapy, Dose-reduced (75%) name: Monotherapy, Standard Dose (100%) name: Monotherapy, Dose-reduced (75%) measure: Progression-Free Survival measure: Quality of Life Questionnaire measure: Quality of Life Questionnaire measure: Physical functioning Questionnaire measure: Physical functioning Questionnaire measure: Grade 3-5 chemotherapy-related toxicity measure: Overall Survival measure: Number of completed treatment cycles measure: Dose reductions during treatment measure: Dose delay during treatment measure: Unplanned hospitalizations measure: Cumulative received dosage measure: Cost-effectiveness sex: ALL minimumAge: 70 Years stdAges: OLDER_ADULT facility: Jeroen Bosch Ziekenhuis city: 's-Hertogenbosch country: Netherlands lat: 51.69917 lon: 5.30417 facility: Noordwest Ziekenhuisgroep city: Alkmaar country: Netherlands lat: 52.63167 lon: 4.74861 facility: Ziekenhuis Amstelland city: Amstelveen country: Netherlands lat: 52.30083 lon: 4.86389 facility: Amsterdam UMC city: Amsterdam country: Netherlands lat: 52.37403 lon: 4.88969 facility: Rijnstate city: Arnhem country: Netherlands lat: 51.98 lon: 5.91111 facility: Wilhelmina Ziekenhuis city: Assen country: Netherlands lat: 52.99667 lon: 6.5625 facility: Rode Kruis Ziekenhuis city: Beverwijk country: Netherlands lat: 52.48333 lon: 4.65694 facility: Haaglanden Medisch Centrum city: Den Haag country: Netherlands lat: 52.07667 lon: 4.29861 facility: Hagaziekenhuis city: Den Haag country: Netherlands lat: 52.07667 lon: 4.29861 facility: Slingeland Ziekenhuis city: Doetinchem country: Netherlands lat: 51.965 lon: 6.28889 facility: Ziekenhuis Gelderse Vallei city: Ede country: Netherlands lat: 52.03333 lon: 5.65833 facility: Catharina Ziekenhuis city: Eindhoven country: Netherlands lat: 51.44083 lon: 5.47778 facility: Treant city: Emmen country: Netherlands lat: 52.77917 lon: 6.90694 facility: Admiraal de Ruyter Ziekenhuis city: Goes country: Netherlands lat: 51.50417 lon: 3.88889 facility: Beatrixziekenhuis city: Gorinchem country: Netherlands lat: 51.83652 lon: 4.97243 facility: Groene Hart Ziekenhuis city: Gouda country: Netherlands lat: 52.01667 lon: 4.70833 facility: Saxenburgh city: Hardenberg country: Netherlands lat: 52.57583 lon: 6.61944 facility: St. Jansdal Ziekenhuis city: Harderwijk country: Netherlands lat: 52.34167 lon: 5.62083 facility: Elkerliek Ziekenhuis city: Helmond country: Netherlands lat: 51.48167 lon: 5.66111 facility: Tergooi MC city: Hilversum country: Netherlands lat: 52.22333 lon: 5.17639 facility: Medisch Centrum Leeuwarden city: Leeuwarden country: Netherlands lat: 53.20139 lon: 5.80859 facility: Leiden University Medical Center city: Leiden country: Netherlands lat: 52.15833 lon: 4.49306 facility: Alrijne Ziekenhuis city: Leiderdorp country: Netherlands lat: 52.15833 lon: 4.52917 facility: Canisius Wilhelmina Ziekenhuis city: Nijmegen country: Netherlands lat: 51.8425 lon: 5.85278 facility: Laurentius Ziekenhuis city: Roermond country: Netherlands lat: 51.19417 lon: 5.9875 facility: Bravis ziekenhuis city: Roosendaal country: Netherlands lat: 51.53083 lon: 4.46528 facility: Ikazia Ziekenhuis city: Rotterdam country: Netherlands lat: 51.9225 lon: 4.47917 facility: Maasstad Ziekenhuis city: Rotterdam country: Netherlands lat: 51.9225 lon: 4.47917 facility: Ommelander Ziekenhuis city: Scheemda country: Netherlands lat: 53.17333 lon: 6.97222 facility: ZorgSaam Zorggroep Zeeuws-Vlaanderen city: Terneuzen country: Netherlands lat: 51.33583 lon: 3.82778 facility: Bernhoven city: Uden country: Netherlands lat: 51.66083 lon: 5.61944 facility: Diakonessenhuis city: Utrecht country: Netherlands lat: 52.09083 lon: 5.12222 facility: St Antonius city: Utrecht country: Netherlands lat: 52.09083 lon: 5.12222 facility: VieCuri Medisch Centrum city: Venlo country: Netherlands lat: 51.37 lon: 6.16806 facility: Streekziekenhuis Koninging Beatrix city: Winterswijk country: Netherlands lat: 51.9725 lon: 6.71944 facility: Zaans Medisch Centrum city: Zaandam country: Netherlands lat: 52.43854 lon: 4.82643 hasResults: False