nctId: NCT06374966 id: 2024-0246 briefTitle: Real-world Study of Efficacy and Safety of Zonisamide in add-on Therapy for Patients With Focal Epilepsy overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-09 date: 2025-12 date: 2024-04-19 date: 2024-04-19 name: Second Affiliated Hospital, School of Medicine, Zhejiang University class: OTHER name: Hangzhou Children's Hospital name: The Fourth Affiliated Hospital of Zhejiang University School of Medicine name: Jinhua Second Hospital name: Ningbo Medical Center Lihuili Hospital name: Ningbo Women & Children's Hospital name: Yuyao People's Hospital name: Huzhou Third People's Hospital name: The Second Affiliated Hospital of Jiaxing University name: Lishui Country People's Hospital briefSummary: Patients were first observed for a 4-week baseline period, which required no medication adjustments and a seizure frequency of greater than or equal to 2 times per 4-week . After the baseline observation period, if the patients met the criteria for enrolment and there were no contraindications, zonisamide was added as an additional therapeutic drug.Clinical data were collected before the initiation of treatment, at 1 month, 3 months and 6 months after taking zonisamide respectively, with regular review of blood tests and urinary ultrasound, and imaging and electrophysiological examinations according to the clinical needs of the patient's actual condition. conditions: Epilepsies, Partial studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 400 type: ESTIMATED name: Zonisamide measure: Effective rate at 6 months of treatment measure: Effective rate at 3 months of treatment measure: Total time to treatment failure measure: Incidence of side effects sex: ALL minimumAge: 2 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Hangzhou Children's Hospital city: Hangzhou state: Zhejiang zip: 310005 country: China name: Zhanli Liu, doctorate role: CONTACT phone: 15968194368 email: liuzhanli@126.com lat: 30.29365 lon: 120.16142 facility: The Second Affiliated Hospital of Zhejiang University School of Medicine city: Hangzhou state: Zhejiang zip: 310009 country: China name: Shuang Wang, doctorate role: CONTACT phone: 13588817561 email: wangs77@zju.edu.cn lat: 30.29365 lon: 120.16142 facility: Huzhou Third People's Hospital city: Huzhou state: Zhejiang zip: 313002 country: China name: Changguo Zhang, doctorate role: CONTACT phone: 15957288075 email: zhangcg1981@163.com lat: 30.8703 lon: 120.0933 facility: Jiaxing Second hospital city: Jiaxing state: Zhejiang zip: 314099 country: China name: Xiaoxiang Yu, doctorate role: CONTACT phone: 13567340650 email: 43262048@qq.com lat: 30.7522 lon: 120.75 facility: Jinhua Second hospital city: Jinhua state: Zhejiang zip: 321016 country: China name: Suhong Ye, doctorate role: CONTACT phone: 13757990511 email: 1073774376@qq.com lat: 29.10678 lon: 119.64421 facility: The Fourth Affilicated Hospital of Zhejiang University School of Medicine city: Jinhua state: Zhejiang zip: 322099 country: China name: Jiajia Fang, doctorate role: CONTACT phone: 15215880868 email: fangjjiaj@zju.edu.cn lat: 29.10678 lon: 119.64421 facility: Lishui People's Hospital city: Lishui state: Zhejiang zip: 323050 country: China name: Likang Lan, doctorate role: CONTACT phone: 18957090351 email: lsllk67@163.com lat: 28.46042 lon: 119.91029 facility: Ningbo Women And Children's Hospital city: Ningbo state: Zhejiang zip: 315012 country: China name: Minghai Huang, doctorate role: CONTACT phone: 13605742462 email: hmhai432@126.com lat: 29.87819 lon: 121.54945 facility: Ningbo Medical center Lihuili hospital city: Ningbo state: Zhejiang zip: 315048 country: China name: Xiaoqin Fan, doctorate role: CONTACT phone: 13685739576 email: fanteacher@163.com lat: 29.87819 lon: 121.54945 facility: Yuyao People's hospital city: Yuyao state: Zhejiang zip: 315499 country: China lat: 30.05 lon: 121.14944 hasResults: False