hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06304311 id: MAHSA/PHD/SON/2024/01 briefTitle: Effectiveness of Backside Massage and Lamaze Breathing on Labour Outcome Among Primigravida overallStatus: COMPLETED date: 2022-10-02 date: 2023-10-02 date: 2024-01-04 date: 2024-03-12 date: 2024-03-12 name: University of Lahore class: OTHER name: Mahsa University briefSummary: The study aims to investigate the effects of a combination of Lamaze breathing exercises and backside massage on the labor experiences of primigravidae in Pakistan. Labour pain, if left unaddressed, can lead to abnormal labor, hence the importance of effective pain management techniques. Lamaze breathing techniques are non-pharmacological methods aimed at psychologically and physically preparing mothers for drug-free childbirth. Backside massage therapy is another non-invasive intervention that can help to reduce pain and anxiety during labor. The study will involve a randomized controlled trial with two groups: an intervention group receiving backside massage and Lamaze breathing along with standard labor care, and a control group receiving only standard labor care. Primigravidae between 26 to 34 weeks of gestation without chronic diseases or pregnancy-related complications will be recruited from antenatal departments. Eligible participants will be randomly allocated to either group to minimize bias. The backside massage therapy intervention will be administered by trained massage therapists. Outcome measures include level of labor pain and anxiety levels, maternal stress hormone levels (adrenocorticotropic hormone, cortisol, and oxytocin), maternal vital signs, fetal heart rate, labor duration, APGAR scores, and maternal satisfaction and self-efficacy. The sample size of 90 participants (45 in each group) has been determined to achieve a 95% power level with a 5% error rate, accounting for a 20% attrition rate. Data analysis will employ mixed-effect regression models, time series analyses, paired t-tests, or equivalent non-parametric tests to assess between-group and within-group outcome measures. The study aims to provide valuable insights into the efficacy of combining Lamaze breathing exercises and backside massage therapy as complementary interventions for managing labor pain and anxiety among primigravidae in Pakistan, potentially reducing the need for medically unnecessary cesarean sections and improving maternal and neonatal outcomes. conditions: Labor Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: INVESTIGATOR count: 90 type: ACTUAL name: Routine Obstetrics care & Lamaze breathing techniques and backside massage measure: Labour pain intensity measure: Anxiety level measure: Duration of Labour measure: Maternal self-efficacy sex: FEMALE minimumAge: 20 Years maximumAge: 35 Years stdAges: ADULT facility: Lady Wallingdon Hospital city: Lahore state: Punjab zip: 54000 country: Pakistan lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06304298 id: 10/2023 briefTitle: NLR and PLR Levels Following iPACK Block in Knee Arthroplasty overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-07-01 date: 2025-08-01 date: 2024-03-12 date: 2024-03-12 name: Poznan University of Medical Sciences class: OTHER briefSummary: Effect of iPACK block on NLR and PLR following knee arthroplasty conditions: Knee Arthropathy conditions: Knee Osteoarthritis conditions: Knee Pain Chronic studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: 0.9% Sodium Chloride Injection name: Ropivacaine 0.2% Injectable Solution measure: Neutrophil-to-lymphocyte ratio measure: Neutrophil-to-lymphocyte ratio measure: Neutrophil-to-lymphocyte ratio measure: PLR measure: PLR measure: PLR measure: first need of opiate measure: Opioid Consumption measure: Pain score measure: Pain score measure: Pain score measure: Pain score measure: Pain score measure: Pain score measure: Pain score sex: ALL minimumAge: 20 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06304285 id: 2023-ky421 briefTitle: A Study Assessing the Effects of Acupuncture in Parkinson's Disease Patients With Chronic Appendicitis overallStatus: RECRUITING date: 2024-03-01 date: 2026-12-31 date: 2026-12-31 date: 2024-03-12 date: 2024-03-12 name: The First Affiliated Hospital of University of Science and Technology of China class: OTHER briefSummary: The incidence of PD is high, and when the disease is serious to a certain extent, the effect of drugs to control symptoms decreases, resulting in a significant reduction in the quality of life of patients. Recent studies have found that these PD symptoms are closely related to the intestine. For several cases of PD syndrome patients complicated with chronic appendicitis, our research group conducted acupuncture on points related to constipation and chronic appendicitis, and found that constipation and related motor symptoms of patients could be significantly improved. Clinical studies have shown that acupuncture also has a certain therapeutic effect on non-motor symptoms of Parkinson's disease, such as anxiety and depression, decreased olfactory function, sleep disorders, constipation, early skeletal muscle pain, cognitive dysfunction, etc., which can delay the progression of the disease and improve the quality of life of patients. Starting from intestinal acupuncture, this project further clarified the role of acupuncture treatment in the comprehensive treatment of PD conditions: Parkinson's Disease conditions: Chronic Appendicitis conditions: Acupuncture studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 84 type: ESTIMATED name: Acupuncture treatment name: Sham acupuncture treatment measure: Score of MDS Unified-Parkinson Disease Rating Scale III sex: ALL minimumAge: 40 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The First Affiliated Hospital of University of Science and Technology of China status: RECRUITING city: Hefei state: Anhui zip: 230001 country: China name: Yuhua Chen, M.M.S. role: CONTACT phone: +8615955236270 email: yh1215@mail.ustc.edu.cn name: Chao Han, M.D. role: CONTACT phone: +8615255629713 email: chaohan@ustc.edu.cn lat: 31.86389 lon: 117.28083 hasResults: False
nctId: NCT06304272 id: Irrigation briefTitle: Comparison Between Drinking Water and Normal Saline in Irrigating Traumatic Wound overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-09 date: 2027-12 date: 2024-03-12 date: 2024-03-12 name: Patan Academy of Health Sciences class: OTHER briefSummary: There is a controversy regarding the roles of the Normal saline and Tap water in irrigation of the wound. It has been suggested that antiseptic solution including normal saline has cytotoxic effect while tap water damages the fibroblast. There are no high level evidence to support one type of solution over other, systematic review have found no difference in wound infection between irrigation with normal saline vs tap water. There are ten randomized controlled trial comparing tap water with normal saline for irrigating wound published between 1992 to 2016. These RCT are analyzed in three systemic review and meta-analysis published on 2016, 2019, 2022, which showed that tap water and normal saline has no difference in terms of infection rate. The infection rate observed in various studies ranges from 0-11.5% in normal saline group and 0-12.6% in tap water group with no statistically significant difference. conditions: Trauma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized, double blinded, parallel, non-inferiority trial primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 440 type: ESTIMATED name: Irrigating Traumatic Wound with Drinking Water measure: Comparison between drinking water and normal saline in irrigating traumatic wound: Noninferiority trial. sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06304259 id: 24428 briefTitle: Effect of Different Modalities of Cryotherapy on Post-Operative Pain in Patients With Symptomatic Irreversible Pulpitis overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-09 date: 2024-10-01 date: 2024-03-12 date: 2024-03-26 name: October 6 University class: OTHER briefSummary: Problem statement: The post-operative pain after endodontic treatment. aim of study: The study is aiming to compare postoperative pain after submucosal cold saline injection (submucosal cryotherapy) (SMC) versus intra-canal cryotherapy (ICC) in mandibular single rooted premolars with symptomatic irreversible pulpitis with symptomatic apical periodontitis (SAP). The material and methods: Subjects and methods: sixty patients will be randomly divided into three groups: the SMC group, the ICC group, and the control group. The patients' postoperative pain will be recorded at 12, 24, and 48 hours postoperatively by questioning them. Quantification of substance P will be done using an ELISA test from peri-radicular fluid swab. conditions: Endodontic Disease conditions: Endodontically Treated Teeth studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 45 type: ESTIMATED name: Saline name: Saline measure: postoperative pain measure: postoperative pain measure: postoperative pain measure: Substance P level measure: Substance P level measure: Substance P level sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Dentistry, Ain shams University city: Cairo zip: 4543070 country: Egypt name: Yara Adel, BDs role: CONTACT phone: 00201000099191 email: yara.adel170496@gmail.com lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06304246 id: FU-S.OZCAN 001 briefTitle: The Relationship Between Preoperative Serum Asprosin Level and Postoperative Analgesic Consumption in Patients Undergoing Caesarean Section overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-08-30 date: 2024-10-30 date: 2024-03-12 date: 2024-03-12 name: Firat University class: OTHER briefSummary: Adipokines are bioactive substances secreted from adipose tissue and have various functions on appetite, energy, lipid, carbohydrate metabolism, regulation of blood pressure, and inflammation. One of these is asprosin, discovered in 2016, which is secreted from white adipose tissue. It has been shown that the level of asprosin encoded by the Fibrillin 1 gene can vary in metabolic syndrome associated with obesity, diabetes, and insulin resistance . Some adipokines such as leptin, adiponectin, or resistin are found in increasing levels in the blood and placenta as pregnancy progresses. The detection of high concentrations of adipokines in cord blood has shown that they play an important role in fetal development and metabolism, can interfere with placental development, and affect pregnancy outcomes and fetal growth. Adipokines associated with appetite, energy, lipid, and carbohydrate metabolism have been shown to be effective in modulating pain in recent years. High levels of leptin have been shown to be associated with decreased preoperative pain threshold and increased postoperative analgesic consumption. Recent studies have indicated that asprosin also exhibits analgesic effects in neuropathic pain models and may have clinical benefits in alleviating chronic pain associated with diseases and injuries originating from peripheral structures.
It is known that one of the most important factors affecting mothers\&#39; approach to anesthesia technique in Cesarean section is their fear of intraoperative and postoperative pain. Almost one in five patients experiences severe acute pain after Cesarean section. Pain can be perceived differently by patients, and even with the same anesthesia technique, some patients may experience more severe pain. Patients\&#39; perception of pain is influenced by many factors such as pain threshold, mood, hormonal balance, central sensitization, and genetic factors.
In this study, we aimed to investigate preoperative serum asprosin levels in patients undergoing Cesarean section with and without acute labor pain and to determine whether there is a relationship between preoperative asprosin levels and postoperative analgesic use. conditions: Obstetric Pain conditions: Cesarean Section conditions: Postoperative Pain studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 25 type: ESTIMATED name: Measurement Pain Threshold name: Measurement of Serum Asprosin measure: Preoperative Asprosin Level measure: Postoperative Pain measure: Postoperative analgesic consumption sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT hasResults: False
nctId: NCT06304220 id: MedroGestrel briefTitle: Comparison of Two PPOS Models for Pituitary Suppression overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-09 date: 2024-12 date: 2024-03-12 date: 2024-03-12 name: NextFertility class: INDUSTRY name: SINAE SL briefSummary: The scarcity of evidence regarding the interchangeable use of different progestogens poses challenges, particularly in international egg donation and fertility preservation programs where standardizing protocols is crucial for achieving consistent efficacy, efficiency, and safety outcomes. Consequently, there's a pressing need for clinical studies to assess the effects of various progestogens on clinical outcomes in controlled ovarian hyperstimulation cycles. This study, a pioneering effort, aims to compare the effects of two progestogens on oocyte performance, safety, and efficiency in an egg donation program involving young, healthy, normo-responding patients. conditions: Infertility, Female conditions: Fertility Disorders studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Prospective, randomized, and controlled clinical study with two different progestogens: desogestrel 75 mg and medroxyprogesterone acetate 10 mg. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 210 type: ESTIMATED name: Cerazet measure: Total number of oocytes retrieved from follicular puncture measure: Number of mature oocytes (MII) retrieved from follicular puncture measure: Oocyte quality variables measure: Ovarian sensitivity index (OSI measure: Follicles sex: FEMALE minimumAge: 18 Years maximumAge: 34 Years stdAges: ADULT facility: NextFertility city: Valencia state: Comunidad Valenciana zip: 46009 country: Spain name: Luis Quintero role: CONTACT phone: +34 963160240 email: luis.quintero@next-clinics.com lat: 39.46975 lon: -0.37739 hasResults: False
nctId: NCT06304207 id: 300423 briefTitle: Telehealth and Onsite Maintenance Exercise in COPD acronym: COPD overallStatus: RECRUITING date: 2023-09-01 date: 2025-12-30 date: 2026-03-01 date: 2024-03-12 date: 2024-03-12 name: MGH Institute of Health Professions class: OTHER briefSummary: The goal of this pilot clinical trial is to compare telehealth and onsite supervised maintenance exercise program for adults with COPD.
Participants in both intervention groups (onsite and tele-rehab) will undergo a baseline onsite assessment followed by an 8-week supervised exercise intervention either onsite or in a telehealth setting. Control group will receive biweekly check in calls, but no active intervention. conditions: Copd conditions: COPD Exacerbation conditions: COPD Bronchitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study design will be a pilot randomized controlled, assessor-blinded trial with three groups: 1) Tele-rehab where patient will be at home but will receive supervised intervention remotely, 2) Onsite outpatient physical therapy, 3) Control group. primaryPurpose: PREVENTION masking: SINGLE maskingDescription: All baseline and follow up outcomes assessment will be conducted by a study team member blinded to the subject group allocation. whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Onsite Maintenance Exercise Training name: Telehealth Maintenance Exercise measure: Exercise Capacity measure: Exercise Capacity measure: Exercise Capacity measure: Dyspnea measure: Dyspnea measure: Dyspnea measure: Physical Function measure: Physical Function measure: Physical Function measure: Quality of life measure measure: Quality of life measure measure: Quality of life measure measure: Inspiratory muscle strength measure: Inspiratory muscle strength measure: Inspiratory muscle strength measure: Physical activity measure: Physical activity measure: Physical activity measure: Participants adherence to the program measure: Healthcare utilization measure: Adverse events measure: PROMIS Global 10 score measure: PROMIS Global 10 score measure: PROMIS Global 10 score sex: ALL minimumAge: 40 Years stdAges: ADULT stdAges: OLDER_ADULT facility: MGH Institute of Health Professions status: RECRUITING city: Charlestown state: Massachusetts zip: 02129 country: United States name: Shweta Gore, PhD role: CONTACT phone: 617-643-6326 email: sgore@mghihp.edu name: Jane Bladwin, DPT role: CONTACT email: jbaldwin@mghihp.edu lat: 42.37787 lon: -71.062 hasResults: False
nctId: NCT06304194 id: BIOMARC_ONCO briefTitle: Molecular Characterizazion and Biological Samples Centralisation of Patients Affected by Oncoematolofic Pathology overallStatus: RECRUITING date: 2023-07-05 date: 2027-07-05 date: 2028-07-05 date: 2024-03-12 date: 2024-03-12 name: Meyer Children's Hospital IRCCS class: OTHER briefSummary: Currently, the molecular characterization of onco-hematological, onco-immunological and hematological diseases, at onset or in relapse, of patients with suspected diagnosis afferent to the CROP centers, is done through centralization of biological samples at reference laboratories outside the Tuscany Region.
In order to preserve the wealth of clinical and biological data and use it for the benefit of present and future patients treated at the CROP centers, it is useful to evaluate the feasibility of centralization and molecular typing of mutations present in tumor tissue at the IRCCS AOU Meyer Oncohematology Laboratories and subsequently the analysis of clinical data from patients with diseases not under study to lay the foundations of a translational database that can then be associated with a biobank in the future.
This will enable a targeted contribution to pediatric oncohematology research, investing in possible targeted therapies with those patient subgroups that benefit from personalized disease assessment in mind. The goal of the project is to improve the regional infrastructure dedicated to organized data collection and management of biological samples in adequate time resulting in better and more comprehensive data collection. conditions: Oncologic Disease conditions: Hematologic Diseases studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 340 type: ESTIMATED name: Analysis of biological samples measure: Average sample delivery time and % of accepted sample measure: Appropriateness sample labelling measure: Percentage of sample suitable for RNA extraction measure: Quantity and quality of extracted material. measure: Research report production time measure: Genetic variants measure: Completed patient cards sex: ALL minimumAge: 0 Years maximumAge: 30 Years stdAges: CHILD stdAges: ADULT facility: Meyer Children's Hospital IRCCS status: RECRUITING city: Florence country: Italy name: Marinella Veltroni role: CONTACT email: marinella.veltroni@meyer.it lat: 43.77925 lon: 11.24626 facility: Azienda Ospedaliero-Universitaria Pisana status: RECRUITING city: Pisa country: Italy name: Gabriella Casazza role: CONTACT lat: 43.70853 lon: 10.4036 facility: Azienda Ospedaliero-Universitaria Senese status: RECRUITING city: Siena country: Italy name: Salvatore Grosso role: CONTACT lat: 43.31822 lon: 11.33064 hasResults: False
nctId: NCT06304181 id: KY-2023-195 briefTitle: Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-08-01 date: 2024-12-30 date: 2024-03-12 date: 2024-03-12 name: The Fourth Affiliated Hospital of Zhejiang University School of Medicine class: OTHER briefSummary: This study thoroughly evaluates the efficacy of acetaminophen mannitol injection for postoperative analgesia in patients undergoing thoracoscopic lobectomy, by comparing it with a control group. conditions: Postoperative Analgesia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 90 type: ESTIMATED name: Paracetamol and Mannitol Injection name: Parecoxib measure: NRS scores measure: RASS score measure: Time of first use of remedial analgesics or analgesic pump measure: Total analgesic pump drug use measure: Postoperative liver enzyme level measure: Postoperative bilirubin level measure: Postoperative creatinine level measure: Postoperative cortisol level measure: Postoperative IL-6 level measure: Postoperative IL-8 level sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
nctId: NCT06304168 id: 19-000890 id: NCI-2024-00954 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: 19-000890 type: OTHER domain: Mayo Clinic Institutional Review Board briefTitle: Validation of DNA Methylation Markers for Universal and Site-specific Guided Cancer Detection, VANGUARD Study overallStatus: RECRUITING date: 2019-05-13 date: 2028-05-15 date: 2028-05-15 date: 2024-03-12 date: 2024-03-12 name: Mayo Clinic class: OTHER briefSummary: This study explores the potential value of a new blood test approach for early detection of cancer. conditions: Hematopoietic and Lymphatic System Neoplasm conditions: Malignant Solid Neoplasm studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 5850 type: ESTIMATED name: Non-Interventional Study measure: Overall cancer (Y/N) - blood test measure: Overall cancer (Y/N) - urine test measure: Cancer specific site prediction - blood samples/MDM measure: Cancer specific site prediction - urine samples/MDM measure: Cancer specific site prediction - blood samples/RNA measure: Cancer specific site prediction - urine samples/RNA sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mayo Clinic in Rochester status: RECRUITING city: Rochester state: Minnesota zip: 55905 country: United States name: Clinical Trials Referral Office role: CONTACT phone: 855-776-0015 email: mayocliniccancerstudies@mayo.edu name: John B. Kisiel, M.D. role: PRINCIPAL_INVESTIGATOR lat: 44.02163 lon: -92.4699 hasResults: False