nctId: NCT06345573 id: BASEC 2020-02922 briefTitle: Heart-brain-axis and Psychosocial Stress overallStatus: ACTIVE_NOT_RECRUITING date: 2021-10-11 date: 2023-11-20 date: 2024-11 date: 2024-04-03 date: 2024-04-08 name: University of Zurich class: OTHER briefSummary: The main study objective is to prospectively determine the influence of sex-related risk factors and psychosocial variables on neuronal stress responses and myocardial perfusion in a population of 64 female and male individuals 50-75 years of age and free of cardiovascular disease. conditions: Mental Stress conditions: Myocardial Ischemia conditions: Sex Role conditions: Gender studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 64 type: ACTUAL name: Mental stress measure: Amygdala-to-cerebellum ratio of glycolytic metabolic activities (SUV/SUV) measure: Difference between the rest and stress amygdala-to-cerebellum perfusion ratios (kBq/kBq) measure: Myocardial flow reserve (MFR, no unit) measure: Amygdala-to-vmPFC ratio of glycolytic metabolic activities (SUV/SUV) measure: Difference between the rest and stress amygdala-to-vmPFC perfusion ratios (kBq/kBq) measure: Myocardial blood flow (MBF) at rest (mL/g/min) measure: Myocardial blood flow (MBF) at stress (mL/g/min) measure: Heart-rate response (HRR, no unit) measure: Salivary cortisol (mol/L) measure: Noradrenaline (mL/min) measure: Adrenaline (mL/min) measure: Dopamine (mL/min) measure: Spleen metabolic activity (SUV) measure: Bone marrow metabolic activity (SUV) measure: Aorta metabolic activity (SUV) measure: Left ventricular ejection fraction (LVEF, %) measure: C-reactive protein (CRP, mg/L) measure: Interleukin-2 (IL-2, pg/mL) measure: Interleukin-4 (IL-4, pg/mL) measure: Interleukin-6 (IL-6, pg/mL) measure: Interleukin-8 (IL-8, pg/mL) measure: Interleukin-10 (IL-10, pg/mL) measure: Tumor necrosis factor (TNF, pg/mL) measure: Matrix metalloproteinase-9 (MMP9, pg/mL) measure: Monocyte Chemoattractant Protein-1 (MCP1, pg/mL) measure: Vascular Cell Adhesion Molecule (VCAM) measure: Gender score questionnaire measure: Rate-Pressure-Product (RPP, in beats per minute x mmHg) measure: vmPFC-to-cerebellum ratio of glycolytic metabolic activities (SUV/SUV) measure: Nail cortisol value (pg/mg) measure: General Anxiety Disorder (GAD-7) Questionnaire measure: Patient Health Questionnaire (PHQ-8) measure: Shortened Maastricht Exhaustion Questionnaire measure: Type D Personality (DS14) questionnaire measure: Wagnild & Young Score resilience questionnaire measure: Perceived Stress Scale (PSS-4) questionnaire measure: Jenkins Sleep Scale (JSS-4) measure: Trier Inventory for Chronic Stress (TICS) measure: Perceived stress measure: Left ventricular stroke volume (LVSV, mL) measure: Left ventricular end-systolic volume (LVESV, mL) measure: Left ventricular end-diastolic volume (LVEDV, mL) measure: Estradiol levels (pmol/L) measure: Progesterone levels (nmol/L) measure: Sex Hormone Binding Globulin (SHBG) levels (nmol/L) measure: Total testosterone levels (nmol/L) measure: Free testosterone levels (pmol/L) sex: ALL minimumAge: 50 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Zurich city: Zürich zip: 8091 country: Switzerland lat: 47.36667 lon: 8.54999 hasResults: False