hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06324656 id: PRP-PNS briefTitle: The Efficacy of Combining Platelet-rich Plasma With Crystallized Phenol in Pilonidal Sinus Disease overallStatus: RECRUITING date: 2023-11-21 date: 2024-04-30 date: 2024-05-30 date: 2024-03-22 date: 2024-03-22 name: Necmi Kadıoğlu Hospital class: OTHER briefSummary: The use of local liquid phenol for pilonidal sinus disease was first introduced by Maurica and Greenwood in 1964. Phenol, also known as carbolic acid, has been proven to be an effective sclerosing agent for treating pilonidal sinus diseas. Its antiseptic and anesthetic qualities make it suitable for application in awake patients under local anesthesia. The treatment of pilonidal sinus diseas in children with crystallized phenol was first published by Ateş et al in 2018. However, the treatment involving only crystallized phenol can require numerous sessions, potentially extending the duration of the treatment. IIn this study, the investigators, investigated whether the application of platelet-rich plasma following crystallized phenol treatment could accelerate the healing process and reach better outcomes. This study evaluates the efficacy of PRP as a treatment modality for pilonidal sinus disease in pediatric patients. conditions: Pilonidal Sinus studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: crystallized phenol + platelet rich plasma application name: crystallized phenol measure: Average time to full daily activities measure: VAS scores measure: Healing time measure: Cosmetic score measure: Success rate measure: Recurrence rate measure: Bleeding rate measure: Infection rate measure: Skin burn rate measure: Total complication rate sex: ALL minimumAge: 1 Day maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Mustafa Azizoğlu status: RECRUITING city: Istanbul zip: 34430 country: Turkey name: Mustafa Azizoğlu role: CONTACT phone: +905447448244 email: mdmazizoglu@gmail.com lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06324643 id: Erb's Palsy briefTitle: Sensory Motor Integration Training in Erb's Palsy Childern overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-04-01 date: 2024-03-22 date: 2024-03-22 name: Sara Elsayed Ali Abdelnaby Ali class: OTHER briefSummary: The aim of the study is to Study effect of sensory motor integration training on ADL activities in children with Erb's palsy. conditions: Sensory Motor Integration and Erb's studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 35 type: ESTIMATED name: sensory motor integration training measure: Effect of sensory motor integration training on ADL sex: ALL minimumAge: 2 Years maximumAge: 6 Years stdAges: CHILD hasResults: False
nctId: NCT06324630 id: 24FIM1266996 briefTitle: Implementation of Innovative Food Prescription Programs in Older Adults overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-06-30 date: 2024-03-22 date: 2024-04-26 name: University at Buffalo class: OTHER briefSummary: In the USA, about 10% of grown-ups have a hard time finding healthy food, like fruits and vegetables. It's even harder for older grown-ups who might be sick and find it tricky to move around, which makes it tough to get healthy food. The investigators are trying to fix this by testing two new ways to help older people (aged 65 and up) get nutritious food. The investigators are getting lots of help and ideas from older adults to make these ways work the best they can.
The study is happening at the Erie County Medical Center (ECMC) in the East Side of Buffalo, NY, where many African Americans live. This place hasn't been treated fairly, so there aren't many places to buy fresh fruits and vegetables in the local stores. On the ECMC campus, there are three clinics that can help people who can't easily get healthy food. Every participant in our study will be put into one of three programs, each lasting 12 weeks, and they will get food every week.
For the second and third programs, participants will get messages to remind the participant when to choose their food, when the time to choose is almost up, and when their food is on its way. If a participant can't use messages or the internet, they can call a helper for support. The investigators believe the study will show that these ways can help older adults who have a hard time getting food to eat more fruits and vegetables. The investigators will also find out which way works best compared to the usual way in the Buffalo, NY area. conditions: Food Preferences conditions: Food Habits studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 75 type: ESTIMATED name: Produce Prescription Delivery name: Healthy Meal Kit Delivery name: Produce Prescription Mobile Market measure: Program Redemption measure: Program Usage measure: Program Interest by Consenting to Being Contacted/Voiced Interest to Recruiter measure: Program Enrollment measure: Fruit and Vegetable Consumption measure: Nutrition Security measure: Self-Efficacy to Purchase, Prepare, and Eat Fresh Fruits and Vegetables measure: Barriers to Eating Fruits and Vegetables measure: Health Status and Disease Risk measure: Quality of Life in Older Age sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT hasResults: False
nctId: NCT06324617 id: soh-Med-24-02-06MS briefTitle: Treatment of Failed Carpal Tunnel Syndrome by Dorsal Ulnar Artery Perforator Adipofascial Flap overallStatus: RECRUITING date: 2024-03-01 date: 2025-12-30 date: 2025-12-30 date: 2024-03-22 date: 2024-03-22 name: Sohag University class: OTHER briefSummary: Carpal tunnel syndrome (CTS) is the most common compressive neuropathy in the general population. Surgical treatment by open or endoscopic carpal tunnel release (CTR) is the first choice of treatment and has clinical success rates of 75% to 90%.The rate of recurrence after primary median nerve release is 3-19% \[1,2\]. Between 0.3% and 12% of cases require surgical revision \[2,3\]. The risk factors for surgical revision for secondary release are male gender, staged or simultaneous bilateral carpal tunnel release, endoscopic release, smoking and rheumatoid arthritis.
Treatment failures after primary CTR are classified as persistent CTS, recurrent CTS, or new symptoms. Recurrent symptoms are uncommon and are defined by a symptom-free interval after surgery. Persistent symptoms are relatively common, particularly in elderly patients and in patients with concurrent nerve compression or medical conditions that affect nerve function, such as diabetes. Persistent or recurrent CTS principally results from incomplete release of the transverse carpal ligament but may be accompanied by perineural scarring, leading to compression or tethering of the median nerve.
To improve outcomes of revision CTR, recent studies have emphasized the importance of median nerve coverage by well-vascularized soft tissue to enhance nerve healing, to prevent tethering in surrounding scar tissue, and to optimize nerve gliding in the carpal tunnel. Several local flaps (hypothenar fat pad flap, tenosynovial flap), regional flaps (posterior interosseous artery flap, reverse radial artery fascial flap, flexor digitorum superficialis flap), and free flap techniques have been described, but consensus for specific flap has not been reached. Following potential iatrogenic median nerve injury and reexploration for a painful neuroma incontinuity, flap coverage may also be beneficial.
In 1988, Becker and Gilbert introduced a Fasciocutaneous pedicled flap based on a consistent dorsal perforator of the ulnar artery (absent in 1 % of population) named the dorsal ulnar artery (DUA) flap or simply the Becker flap. The authors described open revision CTR with nerve coverage by a DUA flap in 3 patients with recurrent CTS and reported good results as well as a quick and easy-to-perform dissection with low donor site morbidity and preservation of the radial andulnar artery. Since this introduction, additional studies describing fasciocutaneous DUA flaps have mostly focused on its use for reconstruction of hand or wrist wounds. Despite the original described benefits, additional studies of DUA flaps for the treatment of recurrent or persistent CTS have remained limited. conditions: Failed Carpal Tunnel Syndrome Surgery studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Treatment of failed carpal tunnel syndrome by dorsal ulnar artery perforator adipofascial flap measure: Pain visual analogue scale (VAS) measure: Two point discrimination test measure: Tinel sign sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Sohag university Hospital status: RECRUITING city: Sohag country: Egypt name: Magdy M Amin, professor role: CONTACT lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06324604 id: MT-101-101 briefTitle: Safety, Pharmacokinetics, and Pharmacodynamics of MTX-101 in Healthy Adults and Patients overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2025-12 date: 2024-03-22 date: 2024-03-22 name: Mozart Therapeutics Australia Pty Ltd class: INDUSTRY briefSummary: First in human study to understand the potential side effects of MTX-101, how long MTX-101 lasts in the human body, and how MTX-101 affects specific human immune cells. conditions: Healthy Volunteers conditions: Celiac Disease conditions: Type 1 Diabetes studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Part A will enroll Healthy Adult Volunteers will be randomized, double-blind, placebo-controlled, single ascending dose (SAD), randomized to MTX-101 or placebo in a 1:1 ratio for the first 2 participants (sentinel dosing) and a 3:1 ratio thereafter. Participants in the multiple ascending dose (MAD) will be randomized in a 3:1 ratio and be dosed on Days 1 and 22 for a total of 2 doses.
Part B of this study plans to enroll at least 24 (up to 40) participants with Celiac Disease or Type 1 Diabetes, randomized in a 1:1 ratio, in a crossover design, dosed with MTX-101 or placebo on Days 1 and 22 for a total of 2 doses primaryPurpose: BASIC_SCIENCE masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 96 type: ESTIMATED name: Placebo name: MTX-101 measure: Safety of single, ascending dose levels of MTX-101 measure: Safety of multiple, ascending dose levels of MTX-101 measure: pharmacokinetics (PK) of MTX-101 measure: pharmacokinetics (PK) of MTX-101 measure: pharmacokinetics (PK) of MTX-101 measure: anti-drug antibody (ADA) formation measure: pharmacodynamics (PD) of MTX-101 measure: Receptor occupancy of MTX-101 sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Nucleus Network Brisbane city: Herston state: Queensland zip: 4006 country: Australia name: Gloria Wong, MD role: CONTACT phone: 1800243733 email: brisbane@nucleusnetwork.com name: Gloria Wong, MD role: PRINCIPAL_INVESTIGATOR lat: -27.44453 lon: 153.01852 hasResults: False
nctId: NCT06324591 id: RISKCROHNBIOM briefTitle: Observational Prospective Study to Identify Intestinal Microbial Profiles in Newly Diagnosed Crohn's Disease Patients overallStatus: ACTIVE_NOT_RECRUITING date: 2021-02-03 date: 2024-08-31 date: 2024-12-31 date: 2024-03-22 date: 2024-03-22 name: Meyer Children's Hospital IRCCS class: OTHER briefSummary: Crohn's disease (CD), a chronic inflammatory disease affecting the intestine, is characterised by a relapsing course. In 25% of cases, the onset of this disease occurs in childhood. Relevant studies have provided evidence of a key role of gut microbial communities (the microbiota) in triggering or maintaining active gut inflammation, pointing to gut dysbiosis as the main event disrupting the balance of microbial communities Recent evidence suggests that, in addition to the bacterial component, the commensal fungal component also plays a crucial role in CD.
The purpose of this prospective, longitudinal, study is to characterise the composition of intestinal bacterial and fungal communities in patients 6-18 years newly diagnosed with Crohn Disease in order to identify a possible association of specific faecal microbial profiles with a severe or mild-to-moderate disease course. conditions: Crohn Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 30 type: ACTUAL name: Collection biological sample and analysis measure: Modifications in alpha and beta diversity of stool microbiome profile in patients with different phases of disease course (at diagnosis, remission and after one year of mantainance therapy) measure: Differences intestinal alpha and beta diversity, microbiome richness and composition between patients at high risk and patients at low risk measure: Indentification of different patterns of intestinal microbiome as a potential biomarker for high and low risk stratification sex: ALL minimumAge: 6 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Medical University of Graz-Educational center for Paediatric Gastroenterology, Hepatology and Nutrition, Department of Paediatrics and adolescence medicine city: Graz country: Austria lat: 47.06667 lon: 15.45 facility: Ospedale Maggiore-Azienda Usl Di Bologna city: Bologna country: Italy lat: 44.49381 lon: 11.33875 facility: Meyer Children's Hospital IRCCS city: Florence country: Italy lat: 43.77925 lon: 11.24626 hasResults: False
nctId: NCT06324578 id: RC 25/2023 briefTitle: Prevalence of Pre-clinical Sjögren Disease and Other Immune Disturbances in Subjects With Autoimmune Thyroiditis Disease overallStatus: RECRUITING date: 2023-09-25 date: 2025-12-31 date: 2025-12-31 date: 2024-03-22 date: 2024-03-22 name: IRCCS Burlo Garofolo class: OTHER briefSummary: The main study hypothesis is that Sjögren Disease (SD), usually considered a disorder typical of adult females, may occur not exceptionally in adolescence or even in childhood as a subclinical process. There are several pieces of evidence in favor of this hypothesis, from the incidental detection of asymptomatic SD in pediatric age to biobank-based studies showing that biological signs of SD may precede the disease clinical onset by years or decades. The best scenario to verify this hypothesis could be that of autoimmune thyroiditis, for the following three reasons: 1) subjects with Autoimmune thyroiditis (AT) have a high risk of developing SD (7%); 2) in cases with comorbidity of SD and AT the diagnosis of AT had usually been made before; 3) subjects with AT routinely undergo periodic blood examination and neck ultrasonography (US), which may include Salivary Gland Ultrasound (SGUS) providing contributive data to detect an asymptomatic pre-SD. The knowledge of the real association between AT and pre-SD may impact on several aspects of medicine. conditions: Sjögren conditions: Autoimmune Thyroid Disease studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 150 type: ESTIMATED name: AT Testing measure: Prevalence of pre-SD in pediatric subjects with AT measure: Prevalence of pre-SD in pediatric subjects with AT measure: Prevalence of pre-SD in pediatric subjects with AT sex: ALL minimumAge: 0 Years maximumAge: 17 Years stdAges: CHILD facility: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" status: RECRUITING city: Trieste zip: 34137 country: Italy name: Alberto Tommasini, MD PhD Prof role: CONTACT phone: +39.040.785.422 email: alberto.tommasini@burlo.trieste.it name: Barbara Bonifacio role: CONTACT phone: +39.040.3785.422 email: barbara.bonifacio@burlo.trieste.it lat: 45.64953 lon: 13.77679 hasResults: False
nctId: NCT06324565 id: RC 24/2021 briefTitle: Role of Preoperative D-dimer Levels in the Diagnosis of Adnexal Torsion overallStatus: RECRUITING date: 2022-01-13 date: 2024-12-13 date: 2024-12-13 date: 2024-03-22 date: 2024-03-22 name: IRCCS Burlo Garofolo class: OTHER briefSummary: Adnexal torsion is the fifth most common gynecologic emergency. Thirty percent of all cases of adnexal torsion occur in females younger than 20 years. Approximately 5 of 100,000 females aged 1-20 years are affected, with girls older than 10 years at increased risk because of hormonal influences and gonadal growth that result in an increased frequency of physiologic and pathologic masses. The most common clinical symptom of torsion is sudden-onset abdominal pain that is intermittent, non-radiating, and associated with nausea and vomiting in 62% and 67% of cases respectively. Moreover, abdominal tenderness is a clinical sign which is reported in up to 88% of patients with adnexal torsion. None of the following tests are useful in the diagnosis of adnexal torsion: leukocytosis, pyuria, C-reactive protein, and erythrocyte sedimentation rate. Actually, transabdominal ultrasonography is the imaging modality of choice with a sensitivity of 92% and specificity of 96% in detecting adnexal torsion. A second-line imaging tool in the diagnosis of adnexal torsion is magnetic resonance, which may require a sedation in selected cases. Consequently, there are no clinical or imaging criteria sufficient to confirm the preoperative diagnosis of adnexal torsion to date. Therefore, patients with a clinical suspicion for adnexal torsion should undergo emergent diagnostic laparoscopy. conditions: Adnexal Torsion studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 130 type: ESTIMATED name: D-Dimer test measure: Diagnostic accuracy of the D-Dimer sex: FEMALE maximumAge: 17 Years stdAges: CHILD facility: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" status: RECRUITING city: Trieste zip: 34137 country: Italy name: Alessandro Boscarelli, MD role: CONTACT phone: +393931757607 email: alessandro.boscarelli@burlo.trieste.it lat: 45.64953 lon: 13.77679 hasResults: False
nctId: NCT06324552 id: RC 16/18 briefTitle: Defects of Keratinocytes Function in Dermatologic Patients overallStatus: RECRUITING date: 2020-10-12 date: 2023-06-03 date: 2024-05-31 date: 2024-03-22 date: 2024-03-22 name: IRCCS Burlo Garofolo class: OTHER briefSummary: NOTCH signaling in the skin exerts a pivotal role in the regulation of normal keratinocytes turnover by mediating the balance between proliferation, differentiation, apoptosis and autophagic flux progression. Two skin diseases are characterized by the presence of gene variants that cause an impairment in NOTCH signaling: hidradenitis suppurativa(HS) and Dowling-Degos disease(DDD). To date, both HS and DDD are orphan diseases still lacking of specific treatments. This project aims at improving the current knowledge on the pathogenesis of HS and DDD, by deepening the understandings on the role played by keratinocytes in these pathologies and also by determining why mutations found in the same pathway cause different diseases. This study aimed to obtain in vitro models, derived directly from patients (from hair follicles) and from keratinocytes (HaCaT) cell cultures, for the study of these skin pathologies and also for the testing of novel innovative therapies such as photobiomodulation therapy. conditions: Hidradenitis Suppurativa studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED measure: Evaluation of the impact of candidate variants in hair follicles epithelial cell biology by generating Knock-Out (KO) keratinocyte cell lines (HaCaT) measure: Evaluation of the impact of photobiomodulation (PBM) therapy in hair follicles epithelial cells derived from patients and in HaCaT KO cells, sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" status: RECRUITING city: Trieste zip: 34137 country: Italy name: Paola Maura Tricarico, BSc role: CONTACT phone: +39 0403785111 email: paolamaura.tricarico@burlo.trieste.it lat: 45.64953 lon: 13.77679 hasResults: False
nctId: NCT06324539 id: PNRR-POC-2022-12376280 briefTitle: Validation of a New Innovative Method for Specific Marker Detection in Celiac Disease overallStatus: RECRUITING date: 2023-10-04 date: 2025-05 date: 2025-05 date: 2024-03-22 date: 2024-03-22 name: IRCCS Burlo Garofolo class: OTHER briefSummary: Celiac disease (CD) is a common auto-immune disorder induced by gluten ingestion in genetically susceptible individuals (HLA-DQ2/DQ8). Gluten induces small-bowel villous atrophy and a specific immune response characterized by the production of CD-autoantibodies against transglutaminase 2 (anti-TG2) and endomysium (EMA). In symptomatic patients with positive-serum antibodies and villous atrophy, the diagnosis of CD is clearcut.
CD-autoantibodies are produced by intestinal B-cells in the early phases of the disease, before their appearance in the serum and when the duodenal mucosa is still normal. Intestinal CD-antibodies (I-CD-abs) are a marker of CD, have a high sensitivity and specificity for CD and identify those patients with potential CD who are at risk of progression to villous atrophy. I-CD-abs can be detected by double immunofluorescence staining on frozen duodenal sections or by using an endomysial antibody assay in the culture medium of duodenal biopsies (EMAbiopsy).
The diagnostic accuracy of these techniques is comparable as they both have high sensitivity and specificity. However, their implementation in clinical practice is limited because they require both experienced operators and well-equipped laboratories. There is an unmet need: the development of a new simple and effective diagnostic tool that any gastroenterology unit can use in routine diagnostics to ensure a prompt diagnosis in suspected CD patients, who may benefit from a therapy based on gluten-free diet, and to reduce both unnecessary medical investigations and diagnostic delays.
In order to simplify and shorten times for the detection of these intestinal antibodies, the study aims to substitute the EMAbiopsy assay with a supernatant obtained quickly after mechanical lysis of fresh intestinal biopsy specimen. The obtained samples will be tested with rapid (about 15 minutes) immune-chromatographic anti-TG2 assay (Rapid Intestinal anti-TG2 Assay). conditions: Celiac Disease in Children studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 332 type: ESTIMATED name: Diagnostic Test: Rapid Intestinal anti-TG2 Assay name: Diagnostic Test: Rapid Intestinal anti-TG2 Assay measure: Sensitivity of the EMA-biopsy in comparison to the reference standard (serology + histology) for CD diagnosis measure: Specificity of the EMA-biopsy in comparison to the reference standard (serology + histology) for CD diagnosis measure: Sensitivity of the Rapid Intestinal anti-TG2 Assay in comparison to the reference standard (serology + histology) for CD diagnosis measure: Specificity of the Rapid Intestinal anti-TG2 Assay in comparison to the reference standard (serology + histology) for CD diagnosis sex: ALL minimumAge: 2 Years maximumAge: 17 Years stdAges: CHILD facility: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" status: RECRUITING city: Trieste zip: 34137 country: Italy name: Luigina De Leo role: CONTACT phone: +39.040.3785.472 email: luigina.deleo@burlo.trieste.it lat: 45.64953 lon: 13.77679 hasResults: False