hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06324812 id: SSGJ-611-PED-AD-Ib/II-01 briefTitle: Evaluation of 611 in Chinese Children and Adolescents With Moderate to Severe Atopic Dermatitis overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-08 date: 2024-08 date: 2024-03-22 date: 2024-03-22 name: Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. class: INDUSTRY briefSummary: The primary objective of the study was to evaluate the safety and pharmacokinetic of 611 in Chinese children and adolescents with moderate to severe atopic dermatitis. conditions: Dermatitis, Atopic studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 104 type: ESTIMATED name: Recombinant Anti-interleukin-4 Receptor Alpha Monoclonal Antibody Injection (611) measure: Adverse events (AEs), measurement of vital signs，physical examination，electrocardiogram and laboratory tests at each visit. measure: Minimum concentration (Cmin) measure: Number of Participants with Eczema Area and Severity Index (EASI) - 75 Response (>= 75% Improvement in Score From Baseline) measure: Number of Participants with Investigator's Global Assessment (IGA) Score of "0" or "1" and Improvement From Baseline of Greater Than or Equal to (>=) 2 Points measure: Number of Participants with Eczema Area and Severity Index (EASI) - 50 Response (>= 50% Improvement in Score From Baseline) measure: Number of Participants with Eczema Area and Severity Index (EASI) - 90 Response (>= 90% Improvement in Score From Baseline) measure: Number of Participants Who Achieved >=4 Points/ >=3 Points With Improvement From Baseline in Weekly Average of Pruritus Numerical Rating Scale (NRS) Score From Baseline measure: Percentage Change From Baseline in EASI Score measure: Change From Baseline in Percent Body Surface Area (BSA) of AD Involvement measure: Change From Baseline in Weekly Average of Pruritus NRS measure: Change From Baseline in Children's Dermatology Life Quality Index (CDLQI) measure: Change From Baseline in Patient Oriented Eczema Measure (POEM) sex: ALL minimumAge: 6 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06324799 id: 2023/51 briefTitle: The Effect of Position Change Frequency on Hyperbilirubinemia overallStatus: RECRUITING date: 2024-03-14 date: 2024-07-14 date: 2024-11-24 date: 2024-03-22 date: 2024-03-22 name: Tarsus University class: OTHER briefSummary: In our study, the effect of the frequency of position changes on hyperbilirubinemia in babies hospitalized in the Neonatal Intensive Care Unit and receiving phototherapy treatment will be investigated.
Babies included in the study will be randomly divided into two groups by randomization method. While the babies in the study group will be subjected to position changes (supine, prone, lateral) every 2 hours, the same procedure will be applied to the control group every 6 hours. All newborns included in the study were treated with the Unitest (Blue angel) LED Phototherapy device, which is used as standard in the neonatal intensive care unit, at a distance of 25-40 cm, at a wavelength of 425-475 nm, at 45 watts, at 50/60 Hz. Phototherapy will be applied unidirectionally. During phototherapy, only the perineal area of the babies will be covered with a reduced diaper, and their eyes will be covered with a three-layer, cotton, black eye patch that transmits 99.5% of ultraviolet rays. During phototherapy sessions, the total serum bilirubin level of the patient is checked; Phototherapy will be continued until it falls below the threshold value in the Bhutani nomogram, which is evaluated according to postnatal days and risk factors. The descriptive characteristics of the babies included in the study and their total bilirubin and hematocrit values before the start of phototherapy will be recorded on the form prepared by the researchers. After phototherapy begins, position changes will be made every two hours for babies in the experimental group and every six hours for babies in the control group until the total serum bilirubin value falls below the phototherapy threshold value in the Bhutani nomogram.
Bilirubin levels will be measured and recorded by venous measurement at the sixth hour and the 24th hour, and this process will be continued regularly until the bilirubin value decreases to the normal range. This practice is performed routinely in the clinic and will not be considered specific to the study. conditions: Newborn; Vitality conditions: Hyperbilirubinemia, Neonatal studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: randomized controlled clinical trial primaryPurpose: OTHER masking: NONE count: 64 type: ESTIMATED name: phototherapy treatment measure: Bhutani Nomogram measure: bilirubin level measure: hematocrit levels sex: ALL minimumAge: 1 Day maximumAge: 15 Days stdAges: CHILD facility: Tarsus State Hospital status: RECRUITING city: Mersin country: Turkey name: Atiye Karakul, Ass. Prof. role: CONTACT phone: 90(324) 600 00 33 phoneExt: 2231 email: atiyekarakul@gmail.com lat: 36.79526 lon: 34.61792 hasResults: False
nctId: NCT06324786 id: 2024 IBMT NF briefTitle: Brain Mechanisms of Reducing Polysubstance Use overallStatus: RECRUITING date: 2023-09-01 date: 2026-08-31 date: 2026-08-31 date: 2024-03-22 date: 2024-03-22 name: Arizona State University class: OTHER briefSummary: The proposed study will test whether neurofeedback (NF) could optimize integrative body-mind training (IBMT) practice. conditions: Multiple Drug Use studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: mindfulness or/and active/sham neurofeedback primaryPurpose: BASIC_SCIENCE masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 35 type: ESTIMATED name: IBMT name: NF measure: Intervention effects on brain function using Functional Magnetic Resonance Imaging (fMRI) measure: Intervention effects on brain white matter using fMRI measure: Intervention effects on brain grey matter using fMRI measure: Intervention effects on addiction behavior using substance use questionnaires in PhenX Toolkit sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: YiYuan Tang status: RECRUITING city: Phoenix state: Arizona zip: 85004 country: United States name: YiYuan Tang role: CONTACT phone: 480-790-3577 email: yiyuan@asu.edu lat: 33.44838 lon: -112.07404 hasResults: False
nctId: NCT06324773 id: 9867 briefTitle: Prevalence of Postpartum Family Planning and Its Association With Spousal Joint Decision-Making in Family Planning overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-06-20 date: 2024-06-30 date: 2024-03-22 date: 2024-03-22 name: Aga Khan University class: OTHER briefSummary: This community-based cross-sectional study investigates the prevalence of postpartum family planning (PPFP) uptake and its association with joint spousal family planning decision-making among married women in rural Sindh, Pakistan. The study, conducted in Thatta District with a population of approximately 0.98 million people, addresses sociodemographic challenges including high fertility rates, maternal and newborn mortality, and low contemporary contraception use. Targeting married women aged 18-49 who gave birth within the past year, the research utilizes data from the Global Network's Maternal and Newborn Health Registry. Data collection involves a pretested questionnaire administered by trained female data collectors. Statistical analysis includes descriptive statistics and logistic regression using STATA 17. The study aims to fill knowledge gaps regarding factors influencing PPFP uptake, particularly the role of joint decision-making in family planning. Findings could inform targeted interventions to enhance maternal and child health, contribute to existing knowledge, and guide policymakers and healthcare providers in addressing the unmet need for family planning in rural Pakistan. conditions: Postpartum Family Planning studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 510 type: ESTIMATED measure: Prevalence of Postpartum Family Planning Uptake measure: Frequency of spousal joint decision making for uptake of postpartum family planning measure: Comparison between spousal joint decision making is using postpartum family planning method and non-users. sex: ALL minimumAge: 15 Years maximumAge: 49 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06324760 id: LIPOICSPI2018 briefTitle: Alpha-lipoic Acid Combined With B Vitamins Shows Promise for Treating Restless Legs Syndrome overallStatus: COMPLETED date: 2020-03-04 date: 2021-06-02 date: 2021-06-02 date: 2024-03-22 date: 2024-03-22 name: Uriach Consumer Healthcare class: INDUSTRY briefSummary: Investigating Tiobec® 400's efficacy in alleviating Restless Legs Syndrome symptoms sheds light on promising therapeutic avenues. conditions: Restless Legs Syndrome studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ACTUAL name: Alpha-lipoic acid combined with B vitamins measure: Measure the subjective RLS symptoms of the participants through the IRLSSG rating scale (IRLS) measure: Anthropometric parameters of the patients. measure: Patients' body measurements measure: Measurements of patient anatomy measure: Patients' body characteristics. measure: Measurements of patient anatomy. sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Medical Center Teknon city: Barcelona zip: 08017 country: Spain lat: 41.38879 lon: 2.15899 hasResults: False
nctId: NCT06324747 id: 23-046 briefTitle: Soft Tissue Stability in Immediate Implant Placement Using (VST) Versus Conventional Flap in Type II Extraction Sockets overallStatus: ACTIVE_NOT_RECRUITING date: 2023-10-23 date: 2024-10-01 date: 2024-12-01 date: 2024-03-22 date: 2024-03-22 name: British University In Egypt class: OTHER briefSummary: This study compare between the vestibular socket therapy (VST) and the traditional mucoperiosteal flap reflection in immediate implant placement in type II extraction socket in the esthetic zone.
The technique of vestibular socket therapy (VST), introduced by Elaskry, enables the placement of implants immediately while simultaneously rehabilitating the entire socket, resulting in excellent esthetic and functional outcomes that meet the expectations of patients. VST involves socket augmentation through a minimally invasive vestibular access incision, eliminating the need for the traditional mucoperiosteal flap reflection, regardless of the extent of socket compromise. conditions: Badly Broken Tooth in a Socket Type II Eligible to be Replaced by Immediate Implant studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two equal parallel groups with a 1:1 allocation ratio to receive either vestibular socket therapy (test group) or to be treated with conventional mucoperiosteal flap (control group). primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Due to the differences in techniques, the operating surgeon can not be blinded to the procedure whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 16 type: ACTUAL name: Vestibular socket therapy name: conventional full thickness flap measure: Soft Tissue Stability measure: Bone Regeneration measure: Pink Esthetic Score (PES) sex: ALL minimumAge: 21 Years maximumAge: 55 Years stdAges: ADULT facility: The British university in Egypt city: Cairo state: New Cairo country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06324734 id: D0817R00082 briefTitle: Assessment of Safety of Olaparib in Chinese Patients With Ovarian Cancer in the Real-World Setting overallStatus: NOT_YET_RECRUITING date: 2024-03-19 date: 2024-07-31 date: 2024-07-31 date: 2024-03-22 date: 2024-03-22 name: AstraZeneca class: INDUSTRY briefSummary: Study D0817R00081 is a retrospective study using NCID database to assess the safety of Olaparib in Chinese patients with ovarian cancer by examining the incidence, seriousness, and severity of all AEs, including but not limiting to AESIs and SAEs, AEs related to Olaparib, and AEs leading to dose reduction, interruption or discontinuation of Olaparib. The first Olaparib prescription date will be set as the index date. The baseline period is from the patient's first ovarian cancer diagnosis recorded in the database to the patient's first treatment with Olaparib (as early as the database start date of January 1, 2013) to the index date for derivation of lines of therapy or one year pre-index date for other baseline variables. Patients will be followed until the patient's last medical record in the database, 30 days after the last dose of Olaparib, death, or June 30, 2023, whichever comes first. All patients who meet the inclusion/exclusion criteria will be enrolled. conditions: Using NCID Database to Assess the Safety of Olaparib in Chinese Patients With Ovarian Cancer by Examining the Incidence, Seriousness, and Severity of All AE studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: RETROSPECTIVE count: 3000 type: ESTIMATED measure: The incidence, seriousness, and severity of all AEs measure: The number and proportion of patients according to different baseline demographics and characteristics measure: Overall number and proportion of patients with olaprib combination maintenance therapy in PSR patients measure: Overall number and proportion of patients with olap arib combination maintenance therapy in 1L patients 2) sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06324721 id: S68133 briefTitle: Why do Patients Report Lymphedema After Breast Cancer Treatment Without an Objective Measurable Swelling acronym: LymphSens overallStatus: RECRUITING date: 2024-03-26 date: 2027-03 date: 2027-03 date: 2024-03-22 date: 2024-04-26 name: Universitaire Ziekenhuizen KU Leuven class: OTHER name: Universiteit Antwerpen briefSummary: Breast cancer related lymphedema (BCRL) is due to its chronicity and impact an extremely dreaded complication after breast cancer treatment.
At this moment, it is not clear how many breast cancer patients experience subjective arm or trunk/breast BCRL and what the underlying mechanisms may be. Therefore, the investigators hypothesize that four mechanisms might be associated with the presence and the severity of subjective arm or trunk/breast BCRL, including sensory processing problems (1. nociceptive and/or 2. neuropathic and/or 3. central) and the presence of disturbed lymphatic transport without clinical manifestation (4. subclinical BCRL).
The investigators will set up a prospective longitudinal study with breast cancer patients to determine the prevalence of subjective and objective arm or trunk/ breast BCRL at 1, 6. and 12 month(s) post-surgery and the transitions between the different types of BCRL and to compare the amount of swelling at arm or trunk/ breast, the presence or severity of subclinical BCRL and peripheral and central sensory processing problems between patients with different types of BCRL. In addition, the present study will be undertaken to determine the contributing factors to the severity of subjective arm or trunk/ breast BCRL within the group of patients with subjective BCRL at different time-points after surgery (at 1, 6. and 12 month(s) post-surgery). conditions: Breast Cancer conditions: Lymphedema conditions: Sensory Processing Disorder studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Prospective cohort study primaryPurpose: SCREENING masking: NONE count: 230 type: ESTIMATED name: Oedema measurements and sensory evaluations measure: Presence of self-reported swelling at arm measure: Presence of self-reported swelling at trunk measure: Presence of self-reported swelling at breast measure: Presence of subjective arm lymphedema measure: Presence of subjective trunk lymphedema measure: Presence of subjective breast lymphedema measure: Relative hand volume difference measure: Relative arm volume difference measure: Extra-cellular water ratio by Bioimpedance Analysis measure: Extra-cellular water ratio by Bioimpedance Spectroscopy measure: Presence of objective arm lymphedema measure: Relative percentage of water content (PWC) ratio measure: Skin thickness measure: Presence of objective trunk lymphedema measure: Presence of objective breast lymphedema measure: Dermal rerouting score at arm measure: Dermal rerouting score at trunk measure: Severity of myofascial adhesions measure: Myofascial tissue stiffness measure: Pressure pain thresholds measure: Arm abduction range measure: Presence of neuropathic pain measure: Mechanical detection thresholds measure: Thermal detection and pain thresholds measure: Sensory acuity measure: Dysfunctional inhibitory pain mechanism measure: Enhanced facilitating mechanism measure: Body perception measure: Severity of subjective arm lymphedema measure: Severity of subjective trunk lymphedema measure: Severity of subjective breast lymphedema sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospitals of Leuven, center for lymphedema status: RECRUITING city: Leuven state: Vlaams-Brabant zip: 3000 country: Belgium name: Nele Devoogdt role: CONTACT email: nele.devoogdt@uzleuven.be name: Ceren Gursen role: CONTACT email: ceren.guersen@kuleuven.be lat: 50.87959 lon: 4.70093 hasResults: False
nctId: NCT06324708 id: THA_DXA briefTitle: Analysis of Defined Elements on DXA in Patients Undergoing Hip Arthroplasty acronym: THA_DXA overallStatus: RECRUITING date: 2023-02-07 date: 2024-10-31 date: 2025-10-31 date: 2024-03-22 date: 2024-03-22 name: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio class: OTHER briefSummary: The purpose of this study is to investigate the role of two-dimensional FEM models obtained from DXA images in the longitudinal assessment of periprosthetic bone, in subjects undergoing hip arthroplasty. Specifically, the study will focus on the joint analysis of changes in the parameters of bone mineral density (BMD) and Bone Strain Index (BSI) at the level of periprosthetic bone of the proximal femur in patients undergoing hip replacement surgery using DXA, evaluating the densitometric variation of these two parameters over time, starting from an immediately postoperative data and checking the change at 6 months to follow the patient through the postoperative course conditions: Bone Resorption conditions: Arthroplasty Complications studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 69 type: ESTIMATED name: DXA measure: Role of two-dimensional FEM models obtained from DXA images in longitudinal evaluation of periprosthetic bone measure: Role of two-dimensional FEM models of bone resistance to loading measure: Identification of mechanical stress measure: Assesment with PROMs: VAS measure: Assesment with PROMs; HHS measure: Assesment with PROMs: SF12 measure: Assesment with PROMs: HOOS PS sex: ALL minimumAge: 50 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Ospedale Galeazzi-Sant'Ambrogio status: RECRUITING city: Milan zip: 20173 country: Italy name: Laura Mangiavini role: CONTACT phone: 0283506790 email: laura.mangiavini@unimi.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06324682 id: 825/2022/Oss/AOUFe briefTitle: ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacing acronym: TREEBEARD overallStatus: RECRUITING date: 2023-01-01 date: 2033-12-31 date: 2034-12-31 date: 2024-03-22 date: 2024-03-22 name: University Hospital of Ferrara class: OTHER briefSummary: The goal of this observational study is to evaluate the clinical characteristics of patients undergoing permanent cardiac pacing and to compare procedural efficacy and safety of different implantation approaches in the clinical practice of the participating centres. The contribution of non-fluoroscopic anatomical and electrophysiological reconstruction systems to device implantation procedures will also be evaluated.
nctId: NCT06324669 id: 4765060 briefTitle: The Effect of a Ketone Drink on Blood Glucose Levels in People With Type 2 Diabetes overallStatus: RECRUITING date: 2024-03-16 date: 2025-01-31 date: 2026-01-31 date: 2024-03-22 date: 2024-03-22 name: University of Exeter class: OTHER name: University of British Columbia name: Medical Research Council briefSummary: Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important in the treatment of type 2 diabetes (T2D). The purpose of this research is to determine if a ketone drink can lower blood sugar in people with T2D following a meal. This research will provide new knowledge about the regulation of blood sugar. This may also inform if ketone drinks could be used as a treatment for T2D. conditions: Type 2 Diabetes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Randomised cross over trial counterbalanced for trial order primaryPurpose: BASIC_SCIENCE masking: QUADRUPLE maskingDescription: Coded, known only to independent individual whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 15 type: ESTIMATED name: Ketone supplement name: Placebo supplement measure: Rate of endogenous glucose production measure: Total rate of glucose appearance measure: Exogenous glucose rate of appearance measure: Total rate of glucose disappearance measure: Rate of gluconeogenesis measure: Rate of glycogenolysis measure: Beta-cell function measure: Insulin concentration measure: Glucagon concentration measure: GLP-1 concentration measure: GIP concentration measure: Glycerol concentration measure: Free fatty acid concentration measure: Ketone concentration measure: Energy expenditure sex: ALL minimumAge: 41 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sport & Health Sciences University of Exeter status: RECRUITING city: Exeter state: Devon zip: EX1 2LU country: United Kingdom name: Francis B Stephens, PhD role: CONTACT phone: +441392 722157 phoneExt: 2157 email: f.b.stephens@exeter.ac.uk lat: 50.7236 lon: -3.52751 hasResults: False