hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06349694 id: PamukkaleU.ftr-NYıldız-001 briefTitle: Comparison of the Efficacy of Transcutaneos Nerve Stimulations in Women With Idiopathic Overactive Bladder overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2025-01-31 date: 2025-02-28 date: 2024-04-05 date: 2024-04-05 name: Pamukkale University class: OTHER briefSummary: Our study is the first prospective randomized controlled trial that compares the effectiveness of transcutaneous medial plantar nerve stimulation (T-MPNS) and transcutaneous tibial nerve stimulation (TTNS) added to bladder training (BT) in women with idiopathic overactive bladder (OAB). İn this study, we aimed to assess the efficacy of T-MPNS and TTNS added to BT on quality of life (QoL) and clinical parameters asssociated with idiopathic OAB. In addition, preparation time for stimulation, treatment satisfaction and discomfort levels of the patients were evaluated.
Is T-MPNS as effective as TTNS in the treatment of idiopathic OAB? For this purpose, we planned to compare transcutaneous applications of the tibial and plantar medial nerve in women with idiopathic OAB. 60 women with OAB will be randomized to 3 groups by using random number generator: BT program alone to Group 1 (n=20), BT plus T-MPNS to Group 2 (n=20), BT plus TTNS to Group 3 (n=20) will be applied. conditions: Urinary Bladder, Overactive studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Transcutaneous MPN stimulation (T-MPNS) name: Transcutaneous tibial nerve stimulation (TTNS) name: BT (Control group) measure: Improvement in incontinence episodes (positive response rate) measure: The severity of incontinence measure: Symptom severity measure: Frequency of voiding, nocturia, number of pads measure: Quality of life (IIQ7) measure: The Hospital Anxiety and Depression Scale (HAD) measure: FSFI measure: Cure-improvement rates measure: Treatment satisfaction sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pamukkale University city: Denizli country: Turkey lat: 37.77417 lon: 29.0875 hasResults: False
nctId: NCT06349681 id: CONOXBird briefTitle: Describe Relations Between qCON and qNOX Indicies During Propofol-Remifentanil General Anesthesia overallStatus: RECRUITING date: 2024-04-01 date: 2024-09-01 date: 2024-10-01 date: 2024-04-05 date: 2024-04-25 name: University of Padova class: OTHER briefSummary: CONOX is a neuromonitoring EEG- device for sedation (qCON) and analgesia (qNOX) monitoring during general anesthesia.
It is unknown on how the indicies can differentiate themselves so aim of this study is to determine the relationship bewtween the 2 indicies. conditions: Anesthesia Brain Monitoring studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 14 type: ESTIMATED measure: Correlation between qCON and qNOX measure: Correlation between qCON and concentrations of Propofol(CeP) measure: Correlation between qNOX and concentrations of Remifentanil (CeR) sex: FEMALE minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Treviso Regional Hospital status: RECRUITING city: Treviso state: TV zip: 31100 country: Italy name: Federico Linassi role: CONTACT email: federico.linassi@gmail.com lat: 45.66673 lon: 12.2416 hasResults: False
nctId: NCT06349668 id: 2023-505941-21-00 briefTitle: Spinal Morphine or Intravenous Lidocaine in Robot-assisted Upper Urologic Surgery acronym: SMILe overallStatus: RECRUITING date: 2024-04-09 date: 2026-10-01 date: 2026-12-01 date: 2024-04-05 date: 2024-04-11 name: Hans Bahlmann class: OTHER name: Linkoeping University briefSummary: The goal of this clinical trial is to learn whether the addition of spinal analgesia leads to superior recovery in patients undergoing robotic-assisted laparoscopic upper urinary tract surgery under general anesthesia. The main questions it aims to answer are:
nctId: NCT06349655 id: 2023-KY-0865-001 briefTitle: The Real-world Clinical Study of Azvudine Tablets in the Treatment of COVID-19 overallStatus: COMPLETED date: 2023-12-05 date: 2024-01-15 date: 2024-03-10 date: 2024-04-05 date: 2024-04-05 name: The First Affiliated Hospital of Zhengzhou University class: OTHER name: Henan Provincial Chest Hospital name: The Affiliated Infectious Disease Hospital of Zhengzhou University name: The Fifth People's Hospital of Anyang name: Shangqiu Municipal Hospital name: Nanyang Central Hospital name: Luoyang Central Hospital name: Guangshan County People's Hospital name: Fengqiu County People's Hospital briefSummary: To establish a real-world clinical cohort and database of Azvudine in the treatment of SARS-CoV-2 infection, and to provide stable and reliable evidence for the clinical efficacy and safety evaluation of azvudine in the treatment of SARS-CoV-2 infection. conditions: COVID-19 conditions: Azvudine studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 32864 type: ACTUAL name: Azvudine name: Paxlovid measure: All-cause death measure: Composite disease progression sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The First Affiliated Hospital of Zhengzhou University city: Zhengzhou state: Henan zip: 450052 country: China lat: 34.75778 lon: 113.64861 hasResults: False
nctId: NCT06349642 id: MC230901 id: 23-008413 type: OTHER domain: Mayo Clinic Institutional Review Board id: NCI-2024-02979 type: REGISTRY domain: CTRP (Clinical Trials Reporting Program) briefTitle: Predicting Response to Immune Checkpoint Inhibitors Across Solid Tumors Using a Live Tumor Diagnostic Platform acronym: CYBRID-04 overallStatus: RECRUITING date: 2024-04-24 date: 2027-05 date: 2027-05 date: 2024-04-05 date: 2024-04-26 name: Mayo Clinic class: OTHER briefSummary: The primary purpose of this study is to determine the sensitivity of CYBRID Score for predicting in-vivo clinical response based on surgical response or RECIST 1.1 for neoadjuvant and locally advanced/metastatic patients, respectively. The secondary purposes is to determine the sensitivity of the CYBRID Score for predicting in-vivo clinical response based on surgical response or RECIST 1.1 for neoadjuvant and locally advanced/metastatic patients, respectively. conditions: Early Stage Triple-Negative Breast Carcinoma conditions: Locally Advanced Bladder Urothelial Carcinoma conditions: Locally Advanced Cervical Carcinoma conditions: Locally Advanced Clear Cell Renal Cell Carcinoma conditions: Locally Advanced Colorectal Carcinoma conditions: Locally Advanced Endometrial Carcinoma conditions: Locally Advanced Esophageal Carcinoma conditions: Locally Advanced Liver Carcinoma conditions: Locally Advanced Lung Non-Small Cell Carcinoma conditions: Locally Advanced Malignant Skin Neoplasm conditions: Locally Advanced Triple-Negative Breast Carcinoma conditions: Metastatic Bladder Urothelial Carcinoma conditions: Metastatic Cervical Carcinoma conditions: Metastatic Clear Cell Renal Cell Carcinoma conditions: Metastatic Colorectal Carcinoma conditions: Metastatic Endometrial Carcinoma conditions: Metastatic Esophageal Carcinoma conditions: Metastatic Liver Carcinoma conditions: Metastatic Lung Non-Small Cell Carcinoma conditions: Metastatic Malignant Skin Neoplasm conditions: Metastatic Malignant Solid Neoplasm conditions: Metastatic Triple-Negative Breast Carcinoma conditions: Resectable Bladder Urothelial Carcinoma conditions: Resectable Colorectal Carcinoma conditions: Resectable Lung Non-Small Cell Carcinoma conditions: Resectable Malignant Liver Neoplasm conditions: Resectable Skin Carcinoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 324 type: ESTIMATED name: Biospecimen Collection name: Tissue Collection measure: Accuracy of cytoplasmic hybrid (Cybrid) Score for predicting in-vivo clinical response sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mayo Clinic in Florida status: RECRUITING city: Jacksonville state: Florida zip: 32224 country: United States name: Clinical Trials Referral Office role: CONTACT phone: 855-776-0015 email: mayocliniccancerstudies@mayo.edu name: Dev Mukhopadhyay, Ph.D. role: PRINCIPAL_INVESTIGATOR lat: 30.33218 lon: -81.65565 hasResults: False
nctId: NCT06349629 id: 20240401 briefTitle: The Clinical Study of 3D-printed Magnesium Alloy Prosthesis With Controllable Degradation Rate in the Repair of Periarticular Bone Defects overallStatus: RECRUITING date: 2023-01-01 date: 2025-01-01 date: 2027-01-01 date: 2024-04-05 date: 2024-04-05 name: Peking University Third Hospital class: OTHER briefSummary: Perimarticular fracture bone defect is a common and complicated clinical disease. The current treatment for this type of injury is anatomical reduction of the fracture, where the bone defect is filled with artificial, autologous or allogeneic bone in granular form, and then fixed with plates and screws. However, these bone filler materials exist in a loose accumulation state and cannot form an effective overall support force for the joint. The applicant realized three dimensional (3D) printing of WE43 magnesium alloy with personalized design and porous overall structure, and developed high-temperature heat treatment technology to slow its degradation, which effectively realized the dual stability of degradation rate of magnesium alloy support body and overall structure during the bone repair period. This project will optimize the design of 3D printed WE43 magnesium alloy full-structure in-bone support, and establish a metamaterial pore structure design platform that regulates the physical properties and degradation behavior of porous implants. Fracture from proximal humerus, distal radius and tibial plateau conditions: Degradation of Magnesium Alloy Prosthesis and New Bone Regeneration studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: 3D printed WE43 magnesium alloy measure: Detection of Magnesium alloy metabolism measure: Degradation of 3D printed magnesium alloy prosthesis measure: New bone regeneration measure: Evaluation of shoulder joint function measure: Evaluation of wrist joint function measure: Evaluation of knee joint function sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking University Third Hospital status: RECRUITING city: Beijing state: Haidian country: China name: Bingchuan Liu role: CONTACT phone: +86 18310188678 email: liubc@bjmu.edu.cn lat: 39.9075 lon: 116.39723 facility: Peking University Third Hospita status: RECRUITING city: Beijing zip: 100083 country: China name: Yun Tian, M.D role: CONTACT phone: +8613701053505 email: tiany@bjmu.edu.cn lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06349616 id: STUDY24458 briefTitle: Cooling Strategies for Older Adults in the Heat overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-12 date: 2026-12 date: 2024-04-05 date: 2024-04-05 name: Penn State University class: OTHER briefSummary: The earth's climate is warming, and the number of heat waves has increased in recent years. At the same time, the number of adults over the age of 65 is growing. Humans sweat and increase blood flow to the skin to cool their body when they get hot. Older adults do not do this as well as young adults. This makes it harder to safely be in warm and/or humid conditions. It is important to learn about cooling strategies for older adults to safely be in warm and/or humid conditions.
There is compelling evidence that intermittent hand and forearm cold-water immersion effectively reduces the rise of core temperature during heat stress in older adults. However, it is still unknown if this is an effective cooling strategy for older adults. Furthermore, our laboratory has shown that folic acid supplementation improves blood flow responses in older adults. This may be beneficial to older adults during heat stress. conditions: Aging studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Subjects participate in 4 experiments, 2 for each treatment (folic acid supplementation and placebo). The order of treatment is random. primaryPurpose: BASIC_SCIENCE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 20 type: ESTIMATED name: Intermittent cold-water hand and forearm immersion name: No intermittent cold-water hand and forearm immersion measure: Core temperature measure: Heart rate measure: Blood Pressure measure: Body Mass measure: Skin Temperature sex: ALL minimumAge: 65 Years maximumAge: 100 Years stdAges: OLDER_ADULT facility: Noll Laboratory city: University Park state: Pennsylvania zip: 16802 country: United States name: W. Larry Kenney, Ph.D. role: CONTACT phone: 814-863-1672 email: w7k@psu.edu name: Rachel Cottle, MS role: CONTACT email: rmc5808@psu.edu lat: 40.80201 lon: -77.85639 hasResults: False
nctId: NCT06349603 id: S2023 briefTitle: Physiotherapy Approach for Susac Syndrome overallStatus: COMPLETED date: 2023-02-13 date: 2023-04-01 date: 2023-04-06 date: 2024-04-05 date: 2024-04-05 name: Rehabilitation Centre Zivot class: OTHER briefSummary: Susac's syndrome is a rare autoimmune disorder characterised by a triad of encephalopathy (brain dysfunction), branch retinal artery occlusion (loss of vision) and sensorineural hearing loss. This study presents the case of a patient undergoing intensive physiotherapy intervention following an injury, focusing on assessments such as volume and range of motion measurements, manual muscle tests, and pain intensity evaluations using various scales. conditions: Susac Syndrome studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 1 type: ACTUAL measure: Mobility and Muscle Strength Improvement measure: Muscle Strength Improvement Outcome Measure measure: Pain Intensity Outcome Measure sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Rehabilitation centre Život city: Mostar zip: 88000 country: Bosnia and Herzegovina lat: 43.34333 lon: 17.80806 hasResults: False
nctId: NCT06349590 id: IRB24-0373 briefTitle: Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery acronym: DIET overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2029-04 date: 2029-04 date: 2024-04-05 date: 2024-04-05 name: University of Chicago class: OTHER briefSummary: A single arm, prospective, single center Phase1/2 Dietary intervention trial for subjects diagnosed with colorectal cancer and scheduled for tumor resection more than 21 days from informed consent. Subjects will be provided 21 days of standardized plant-based low fat/ high-fiber meals and complete a food diary up until lunch on the day prior to surgery. Blood samples will be collected at baseline and on the day of surgery. Stool samples will be collected throughout the dietary intervention period at specific timepoints, on the day of surgery, and 30 days post-surgery. Tissue from the tumor resection will be isolated for organoid cultures. Subjects will be followed per standard of care for up to 5 years or disease recurrence, whichever comes first. Subject may be treated for their cancer prior to surgery and/or during the follow-up period. conditions: Colorectal Cancer studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 20 type: ESTIMATED name: Plant-Based Meals measure: Change of the presence of active-urokinase-type plasminogen activation (uPA) stool samples before and after diet intervention using western blot and zymography. measure: Change of the presence of active- Matrix Metalloproteinase-9 (MMP9) in stool samples before and after diet intervention using western blot and zymography. measure: Change of the presence of plasminogen in stool samples before and after diet intervention using western blot and zymography. measure: Change of the stool associated metagenomics in subjects before and after intervention. measure: Change of the levels of short-chain fatty acids and bile acids between pre- and post- intervention stool samples. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Chicago city: Chicago state: Illinois zip: 60637 country: United States name: Benjamin Shogan, MD role: CONTACT phone: 773-732-2260 email: bshogan@bsd.uchicago.edu name: Leila Yazdanbakhsh role: CONTACT phone: 773-834-6087 email: leila.yazdanbakhsh@bsd.uchicago.edu name: Benjamin Shogan, MD role: PRINCIPAL_INVESTIGATOR lat: 41.85003 lon: -87.65005 hasResults: False
nctId: NCT06349577 id: 23-0921 id: 5K23HL151882 type: NIH link: https://reporter.nih.gov/quickSearch/5K23HL151882 briefTitle: Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2028-04 date: 2028-10 date: 2024-04-05 date: 2024-04-05 name: University of Colorado, Denver class: OTHER name: National Heart, Lung, and Blood Institute (NHLBI) briefSummary: The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery. Investigators will also evaluate the safety and impact of pulsatile flow on clinical outcomes compared to non-pulsatile flow during cardiopulmonary bypass. conditions: Acute Kidney Injury conditions: Hemolysis conditions: Thrombocytopenia conditions: Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 1100 type: ESTIMATED name: Non-pulsatile blood flow name: Pulsatile blood flow measure: Acute kidney injury measure: Acute kidney injury risk score measure: Red blood cell units transfused measure: Platelet nadir measure: Discontinuation rate of cardiopulmonary bypass mode measure: 30-day mortality measure: Myocardial infarction measure: Stroke measure: Renal failure requiring renal replacement therapy measure: Re-exploration for bleeding measure: Sepsis measure: New onset atrial fibrillation measure: Duration of mechanical ventilation measure: Post-operative delirium measure: Post-operative hospital length of stay measure: New requirement for mechanical circulatory support measure: Intra-operative red blood cell transfusion in units measure: Post-operative red blood cell transfusion in units measure: Post-operative platelet transfusion in units measure: Post-operative plasma transfusion in units measure: Post-operative cryoprecipitate transfusion in units measure: Intra-operative platelet transfusion in units measure: Intra-operative plasma transfusion in units measure: Intra-operative cryoprecipitate transfusion in units measure: New onset of acute lung injury measure: New onset of left ventricular systolic dysfunction measure: New onset of right ventricular systolic dysfunction sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Colorado Hospital city: Aurora state: Colorado zip: 80045 country: United States lat: 39.72943 lon: -104.83192 hasResults: False
nctId: NCT06349564 id: 23-01443 briefTitle: Implementing Virtual Reality (VR) to Reduce Sedation overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-04-05 date: 2024-04-05 name: NYU Langone Health class: OTHER briefSummary: The study is a prospective pilot patients aged 21 to 65 undergoing screening colonoscopy or diagnostic upper endoscopy. Patients are administered minimal sedation (2 mg of Versed and 25 mg of Fentanyl) and are given Virtual Reality (VR) goggles to wear for the duration of the procedure. The purpose of this study is to assess the feasibility, effect, and safety of using VR goggles during endoscopic procedures to decrease sedation requirements, enhance patient satisfaction, and reduce recovery time. conditions: Sedative During Endoscopy studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 20 type: ESTIMATED name: Pico 4 Enterprise headset with noise cancelling headphones measure: Total amount of sedative drugs administered during the procedure measure: Patient-reported discomfort or pain (using 0-10 pain scale) measure: Duration of the procedure measure: Overall patient satisfaction scores measure: Number of events of complications from VR measure: Number of technical failures measure: Troubleshooting time measure: PACU length of stay sex: ALL minimumAge: 21 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: NYU Langone Brooklyn city: Brooklyn state: New York zip: 11220 country: United States lat: 40.6501 lon: -73.94958 hasResults: False
nctId: NCT06349551 id: RC23_0586 briefTitle: Clot Formation and Coagulation Factors Consumption in the Clearing Fluid After Arterial Catheter Blood Sampling. acronym: SECU-BIO2 overallStatus: RECRUITING date: 2024-04-17 date: 2025-03-20 date: 2025-03-20 date: 2024-04-05 date: 2024-04-18 name: Nantes University Hospital class: OTHER briefSummary: After blood sampling from an arterial catheter, the reinjection of the clearing fluid (a mixture of saline solution and blood) is proposed to limit blood loss. However, the status of coagulation in this clearing liquid remains poorly documented. conditions: Intensive Care Units conditions: Arterial Lines studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 211 type: ESTIMATED name: Patients of intensive care unit measure: Composite score of the coagulation activation over time in the clearing fluid during blood sampling from an arterial catheter measure: Concentration of prothrombin over time in the clearing fluid during blood sampling from an arterial catheter measure: Concentration of factor II over time in the clearing fluid during blood sampling from an arterial catheter measure: Concentration of factor V over time in the clearing fluid during blood sampling from an arterial catheter measure: Concentration of fibrin monomer over time in the clearing fluid during blood sampling from an arterial catheter sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Nantes university hospital status: RECRUITING city: Nantes state: Loire-atlantique zip: 44093 country: France name: Jerôme Dauvergne role: CONTACT phone: +33240165289 email: jerome.dauvergne@chu-nantes.fr lat: 47.21725 lon: -1.55336 facility: Hospital center status: NOT_YET_RECRUITING city: Saint-Nazaire zip: 44606 country: France name: Damien Muller, Dr role: CONTACT phone: 02 72 27 89 89 email: dmuller.med@gmail.com lat: 47.28333 lon: -2.2 hasResults: False
nctId: NCT06349538 id: 35-435 ex 22/23 briefTitle: Identifying Markers of Disease Subtypes and Disease Progression in the Syndrome of Essential Tremor overallStatus: ENROLLING_BY_INVITATION date: 2024-04-04 date: 2026-04-30 date: 2034-04-30 date: 2024-04-05 date: 2024-04-16 name: Medical University of Graz class: OTHER briefSummary: The goal of this observational study is to learn about epidemiology, biologic markers, disease subtypes and possible prognostic factors in essential tremor (ET) patients. The main question\[s\] it aims to answer are: