nctId: NCT06277037 id: AB-729-204 briefTitle: Long-Term Follow-up Study for Subjects With CHB Previously Treated With Imdusiran (AB729) overallStatus: NOT_YET_RECRUITING date: 2024-07-15 date: 2029-08-30 date: 2029-10-30 date: 2024-02-26 date: 2024-04-01 name: Arbutus Biopharma Corporation class: INDUSTRY briefSummary: This is a long term follow-up study for chronic hepatitis B (CHB) subjects who have received imdusiran treatment in a prior clinical trial, stopped NA therapy during that trial, and remain off therapy. Subjects may enroll after completing the end of study visit (baseline visit within 12 weeks ± 1 week from the end of study \[EOS\] visit) from their imdusiran clinical trial (the "parent study"). No interventions will be performed in this study other than blood sample collections, review of current medications, and reporting of any adverse events related to study procedures or NA therapy if restarted. Study participation will be for approximately 2 years (to complete a total of at least 3 years of follow-up while off NA therapy, inclusive of parent study participation). conditions: Long Term Follow-up studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: OTHER count: 35 type: ESTIMATED name: Non-interventional measure: To evaluate the durability of effect of imdusiran on HBV parameters measure: To evaluate the durability of effect of imdusiran on HBV parameters measure: To evaluate the durability of effect of imdusiran on HBV parameters sex: ALL minimumAge: 20 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Alfred Hospital city: Melbourne state: Victoria zip: 3004 country: Australia name: Stuart Roberts role: CONTACT role: CONTACT email: S.Roberts@alfred.org.au lat: -37.814 lon: 144.96332 facility: Fiona Stanley Hospital city: Murdoch zip: 6150 country: Australia name: Sam Galhenage role: CONTACT lat: -32.06987 lon: 115.83757 facility: Queen Mary Hospital city: Hong Kong country: Hong Kong lat: 22.27832 lon: 114.17469 facility: Prince of Wales Hospital city: Shatin country: Hong Kong name: Grace Wong role: CONTACT lat: 22.38333 lon: 114.18333 facility: Changhua Christian Hospital city: Changhua city zip: 600566 country: Taiwan lat: 24.07327 lon: 120.56276 facility: Chia-Yi Christian Hospital city: Chiayi City zip: 60002 country: Taiwan name: Chi-Yi Chen role: CONTACT lat: 23.47917 lon: 120.44889 facility: Kaohsiung Medical University Chung-Ho Memorial Hospital city: Kaohsiung zip: 80756 country: Taiwan name: Wan-Long Chuang role: CONTACT lat: 22.61626 lon: 120.31333 facility: E-Da Hospital city: Kaohsiung zip: 82445 country: Taiwan name: Gin-Ho Lo role: CONTACT lat: 22.61626 lon: 120.31333 facility: Taichung Veterans General Hospital city: Taichung zip: 40705 country: Taiwan name: Sheng-Shun Yang role: CONTACT lat: 24.1469 lon: 120.6839 facility: Chang Gung Medical Foundation Linkou city: Taoyuan zip: 33305 country: Taiwan name: Chao-Wei Hsu role: CONTACT lat: 24.95233 lon: 121.20193 facility: University Hospital of Wales, Cardiff city: Cardiff zip: CF144XW country: United Kingdom name: Jonathan Underwood role: CONTACT lat: 51.48 lon: -3.18 facility: Royal London Hospital city: London zip: E11FR country: United Kingdom lat: 51.50853 lon: -0.12574 facility: King's College Hospital city: London zip: SE59RS country: United Kingdom name: Kosh Agarwal role: CONTACT lat: 51.50853 lon: -0.12574 hasResults: False