hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06376565 id: 22-000647 id: NCI-2024-02090 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: R01CA271034 type: NIH link: https://reporter.nih.gov/quickSearch/R01CA271034 briefTitle: Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps overallStatus: NOT_YET_RECRUITING date: 2024-05-05 date: 2027-03-31 date: 2028-03 date: 2024-04-19 date: 2024-04-24 name: Jonsson Comprehensive Cancer Center class: OTHER name: National Cancer Institute (NCI) briefSummary: This clinical trial tests a multilevel intervention at the clinic, provider and patient levels, to improve colonoscopy surveillance in patients with high risk colon polyps. Colorectal cancer (CRC) is a common and deadly disease that is largely preventable through the detection and removal of colorectal polyps. One million Americans are diagnosed with high risk polyps of the colon or rectum annually and are at increased risk for CRC; however, uptake of recommended repeat colonoscopy in 3 years to reduce CRC risk is low in this group. This multilevel intervention may work to improve timely colonoscopy screening for patients with high risk colon polyps. conditions: Colorectal Carcinoma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: NONE count: 1680 type: ESTIMATED name: Best Practice name: Communication Intervention name: Communication Intervention name: Communication Intervention name: Interview name: Interview measure: Stakeholder perspectives on the multilevel intervention (Aim 1) measure: Completion of surveillance colonoscopy (Aim 2) measure: Implementation quality (Aim 3a) measure: Cost effectiveness (Aim 3b) measure: Time from high risk neoplasia (HRN) diagnosis to colonoscopy (Aim 2) sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: UCLA / Jonsson Comprehensive Cancer Center city: Los Angeles state: California zip: 90095 country: United States name: Folasade P. May role: CONTACT phone: 617-620-7806 email: FMAY@MEDNET.UCLA.EDU name: Folasade P. May role: PRINCIPAL_INVESTIGATOR lat: 34.05223 lon: -118.24368 hasResults: False
nctId: NCT06376552 id: AI4Cardio briefTitle: Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome acronym: AI4Cardio overallStatus: COMPLETED date: 2018-12-19 date: 2022-06-06 date: 2022-06-06 date: 2024-04-19 date: 2024-04-19 name: IRCCS San Raffaele class: OTHER briefSummary: Brugada Syndrome (BS) is an inherited heart condition that can cause sudden cardiac arrest in young individuals. It's diagnosed through specific changes seen on an electrocardiogram (ECG). Currently, the only treatment option is a cardioverter defibrillator (ICD). Despite advances, much about BS remains unclear, including its genetic basis. This study aims to use advanced genetic sequencing and artificial intelligence to uncover new genetic factors contributing to BS. By understanding these factors better, we hope to improve risk assessment and treatment for affected individuals. conditions: Brugada Syndrome studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 200 type: ACTUAL measure: New candidate genes, likely associated with Brugada Syndrome using an AI based approach. measure: Identification of genetic risk factors associated with the worse phenotype. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS San Raffaele city: Milan zip: 20132 country: Italy lat: 45.46427 lon: 9.18951 facility: Milano-Bicocca University city: Milan country: Italy lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06376539 id: CEAVEC: 111/2024/Oss/IOR briefTitle: Functional Recovery of Patients Undergoing Resection and Reconstruction of the Lower Limbs for Bone Tumor. acronym: FISIO-ONCO overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-05 date: 2025-04 date: 2024-04-19 date: 2024-04-19 name: Istituto Ortopedico Rizzoli class: OTHER briefSummary: The aim of the present study is to describe the course of functional recovery of patients with musculoskeletal tumours and undergone resection and reconstruction operations of lower limbs in the first six months post-surgery, differentiating them on the basis of the anatomical level involved. conditions: Bone Neoplasm conditions: Rehabilitation studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 100 type: ESTIMATED measure: Toronto Extremity Salvage Score (TESS) measure: Toronto Extremity Salvage Score (TESS) measure: Range of motion (ROM) measure: Rang of motion - 2 (ROM) measure: Number of participants able to walk measure: Time Up and Go -2 (TUG) measure: Time Up and Go (TUG) measure: Muscle Strength measure: Muscle Strength-2 measure: Number of day from surgery to first walking sex: ALL minimumAge: 12 Years maximumAge: 70 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06376526 id: 20230236 briefTitle: IMMUNOPLANT for Newly Diagnosed Multiple Myeloma acronym: IMMUNOPLANT overallStatus: NOT_YET_RECRUITING date: 2024-06-30 date: 2027-06-30 date: 2029-06-30 date: 2024-04-19 date: 2024-04-19 name: Dickran Kazandjian, MD class: OTHER name: Regeneron Pharmaceuticals briefSummary: The purpose of this study is to determine whether Linvoseltamab therapy in patients with newly diagnosed multiple myeloma will convert the disease status from minimal residual disease (MRD)-positive to MRD-negative, and increase the length of time that the disease is controlled. The researchers also want to find out the effects (good and bad) that Linvoseltamab has on participants and the condition. conditions: Multiple Myeloma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 28 type: ESTIMATED name: Linvoseltamab measure: Minimal Residual Disease (MRD) Negativity Rate measure: Sustained MRD-Negativity Rate measure: Progression-Free Survival (PFS) measure: Overall Survival measure: Number of Participants Experiencing Treatment-Related Adverse Events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Miami city: Miami state: Florida zip: 33136 country: United States name: Dickran Kazandjian, MD role: CONTACT phone: 305-243-5001 email: dkazandjian@miami.edu name: Dickran Kazandjian, MD role: PRINCIPAL_INVESTIGATOR lat: 25.77427 lon: -80.19366 hasResults: False
nctId: NCT06376513 id: 69HCL24_0031 briefTitle: Evaluation of Penile Prosthesis Pump Manipulation acronym: ECM3P overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-12-01 date: 2025-12-01 date: 2024-04-19 date: 2024-04-19 name: Hospices Civils de Lyon class: OTHER briefSummary: Erectile dysfunction is a highly prevalent pathology. When oral or injectable pharmacological treatments prove ineffective, the treatment of choice is penile prosthesis which provides the possibility of sexual activity with penetration.
* Satisfaction related to pump manipulation conditions: Penile Prosthesis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 60 type: ESTIMATED name: Evaluation measure: Describing the manipulation abilities of patients with penile prosthesis : overall hand grip strength measure: Describing the manipulation abilities of patients with penile prosthesis : pinch grip strength measure: Describing the manipulation abilities of patients with penile prosthesis : proprioception measure: Describing the manipulation abilities of patients with penile prosthesis :discrimination measure: Describing the manipulation abilities of patients with penile prosthesis :upper limb function for activities of daily living measure: Correlation of manipulation parameters (main outcome) with rigidity of erections measure: Correlation of manipulation parameters (main outcome) with patient's sexual satisfaction modified EDITS measure: Correlation of manipulation parameters (main outcome) with patient's sexual satisfaction QoLSPP measure: Correlation of manipulation parameters (main outcome) with partner's sexual satisfaction measure: Correlation of manipulation parameters (main outcome) with satisfaction related to pump manipulation (self-made questionnaire) sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Urology, Lyon Sud Hospital, city: Pierre-Bénite zip: 69310 country: France name: Nicolas MOREL role: CONTACT phone: + 33 4 72 6788 37 email: nicolas.morel-journel@chu-lyon.fr name: Clément PARAT role: CONTACT phone: + 33 4 72 6788 37 email: clement.parat@chu-lyon.fr lat: 45.7009 lon: 4.82511 hasResults: False
nctId: NCT06376500 id: HSEARS20240223001 briefTitle: Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2027-08 date: 2028-02 date: 2024-04-19 date: 2024-04-19 name: The Hong Kong Polytechnic University class: OTHER briefSummary: Globally, 10 million new traumatic brain injury (TBI) cases are estimated annually, with mild traumatic brain injury (mTBI) accounting for 75-90% of all TBI cases. It is estimated that 40-80% of individuals with mTBI may experience the post-concussion syndrome (PCS), which is characterized by a range of physical, cognitive, and emotional symptoms. Although the underlying basis of cognitive dysfunction of patients with persistent PCS remains to be clarified, converging evidence shows that the clinical symptoms is underpinned by abnormal neural information processing as a result of axonal injury due to mTBI. Recent studies have demonstrated abnormalities in both structural and functional cortical connectivity, and a loss of cortical excitability-inhibitory (E/I) balance after TBI. Yet, there is no consensus for treating chronic symptoms of concussion, and PCS remains a chronic and highly disabling condition. One potential treatment option is transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique that has been shown to modify behavior by enhancing connectivity between targeted brain areas. However, research on the therapeutic effect of tDCS on PCS symptoms is limited, and the neurologic mechanisms underlying its effects are not well understood. The proposed study aims to address these knowledge gaps by examining the effects of tDCS on the central nervous system function in patients with PCS, with a specific focus on functional cortical connectivity and cognitive functions such as processing speed and executive function. The study also aims to add value to existing evidence by potentially opening new directions for designing intervention programs for the treatment of PCS after mTBI. conditions: Transcranial Direct Current Stimulation conditions: Post-Concussion Syndrome conditions: Functional Magnetic Resonance Imaging conditions: Magnetic Resonance Spectroscopy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: tDCS with cognitive training programme measure: Executive function measure: Change in CANTAB® cognitive test - Reaction Time (RTI) measure: Change in CANTAB® cognitive test - Multitasking Test (MTT) measure: Change in CANTAB® cognitive test - Spatial Working Memory (SWM) measure: Exploratory mediator - default mode network (DMN) activation measure: Exploratory mediator - excitability-inhibitory (E/I) ratio sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Hong Kong Polytechnic University city: Hung Hom state: Kowloon country: Hong Kong lat: 22.30715 lon: 114.18532 hasResults: False
nctId: NCT06376487 id: 75202423.2.0000.0071 briefTitle: Pulmonary Aeration and Muscle Thickening Fraction: Association of Electrical Impedance Tomography and Ultrasound overallStatus: RECRUITING date: 2024-05-01 date: 2025-07-31 date: 2026-01-31 date: 2024-04-19 date: 2024-04-19 name: Hospital Israelita Albert Einstein class: OTHER name: Fundação de Amparo à Pesquisa do Estado de São Paulo name: Feculdade de Medicina da Universidade de Sao Paulo - Brasil briefSummary: The goal of this prospective clinical study is to evaluate the effect of different High Flow Nasal Cannula (HFNC) flow rates on diaphragm, rectoabdominal, and oblique thickening fraction, and to determine whether this effect depends on the action of HFNC flow rates on Functional Residual Capacity (FRC) in Infants under 2 years of age with a diagnosis of bronchiolitis and indication for use of HFNC. The main question\[s\] it aims to answer are:
Four different randomized flow rates will be used for evaluation: 2.0 liter.Kg-1.min-1, 1.5 liter.Kg-1.min-1, 1.0 liter.Kg-1.min-1, 0.5 liter.Kg-1.min-1. At the end of the randomized order evaluation the infant will remain in the flow of 0.5 liter.Kg-1.min-1 for 5 minutes and then return to the flow of 2.0 liter.Kg-1.min-1. The EIT parameters, ultrasound assessment, and clinical variables will be collected at the end of the 5-minute stay in each lane.
The randomization of the order of application of the phases will be carried out in blocks, so that the homogeneity of the sequences is maintained even if the collection is interrupted before reaching the total number of individuals. The blocks will be of size two and four and the test and production lists will be generated with the help of the R packages. conditions: Bronchiolitis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: A prospective clinical study to evaluated four different flow rate in infants with bronchiolitis using high flow nasal cannula primaryPurpose: SUPPORTIVE_CARE masking: NONE maskingDescription: Patient will not know the flow rate sequence used during the assessment count: 82 type: ESTIMATED name: Flow rate evaluation measure: diaphragm thickening fraction measure: abdominal muscle thickening fraction measure: EELZ (end-expiration lung impedance) sex: ALL maximumAge: 24 Months stdAges: CHILD facility: Hospital Israelita Albert Eisntein status: RECRUITING city: São Paulo zip: 05653000 country: Brazil name: Milena S Nascimento role: CONTACT phone: 55 11 984520061 email: milena.nascimento@einstein.br lat: -23.5475 lon: -46.63611 hasResults: False
nctId: NCT06376474 id: HM005PS1S06 briefTitle: To Evaluate the Pharmacokinetics of Hemay005 Tablets in Subjects With Liver Damage overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2024-12 date: 2024-04-19 date: 2024-04-19 name: Ganzhou Hemay Pharmaceutical Co., Ltd class: INDUSTRY briefSummary: The purpose of this study was to evaluate the pharmacokinetics of Hemay 005 tablets in subjects with mild, moderate liver impairment and normal liver function, and to provide a basis for the formulation of clinical medication regimens for patients with liver impairment. conditions: Psoriasis studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 24 type: ESTIMATED name: Hemay005 measure: Relevant pharmacokinetic parameters，Peak Plasma Concentration（Cmax） measure: Relevant pharmacokinetic parameters，Area under the plasma concentration versus time curve（AUC0-t） measure: Relevant pharmacokinetic parameters，Area under the curve from time 0 extrapolated to infinite time (AUC0-inf) measure: Relevant pharmacokinetic parameters，half-life (T1/2) measure: Relevant pharmacokinetic parameters，clearance (CL/F) measure: Relevant pharmacokinetic parameters，volume of distribution (Vz/F) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06376461 id: 333874 briefTitle: Prospective, Multicentre Study to Validate the GastroIntestinal Dysfunction Score (GIDS) and Describe Prevalence, Outcomes, and Management of Phosphate Disorders in Intensive Care Patients acronym: GUTPHOS overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-07 date: 2024-12 date: 2024-04-19 date: 2024-04-22 name: University Hospitals of North Midlands NHS Trust class: OTHER briefSummary: Part A Multiple organ dysfunction syndrome is one of the main problems in critically ill patients. Several organ dysfunctions are routinely and systematically monitored in patients admitted to intensive care units. Gastrointestinal dysfunction is currently not included in multiple organ dysfunction scores and lacks a standardised approach. At the same time, investigators earlier studies have shown that gastrointestinal dysfunction plays an essential role in the course of illness in intensive care patients. A tool for measuring dysfunction is needed to enable future studies on interventions to improve gastrointestinal function. The GIDS (GastroIntestinal Dysfunction Score) combines different clinical signs and symptoms commonly observed and documented in patients in the ICU into a scoring system, allowing distinguishing between different grades of severity of dysfunction. The investigators will only use observations documented during the patient's stay in the intensive care unit without additional measurements and calculate gastrointestinal (GIDS) and other organ dysfunction scores.
Part B Phosphate is an electrolyte commonly measured and often corrected, while the indications and clear guidance for correction are insufficiently studied. The results of this study will assist in specifying indications for the correction of phosphate levels better and refine the management strategies in the future. Only phosphate levels measured as part of routine care will be documented, no additional samples for study purposes will be taken, and the study will not influence the treatment of phosphate disorders. conditions: Gastrointestinal Dysfunction studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 120 type: ESTIMATED name: Data collection measure: 28 day outcome measure: 90 day outcome measure: ICU length of stay measure: ICU length of stay measure: Hospital length of stay measure: Hospital length of stay measure: Free of organ support sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospitals of North Midlands NHS Trust city: Stoke-on-Trent country: United Kingdom lat: 53.00415 lon: -2.18538 hasResults: False
nctId: NCT06376448 id: cc-obs-01 briefTitle: An Observational Study Using Novel Questionnaire to Characterize Cough Phenotypes in Patients With Chronic Cough overallStatus: RECRUITING date: 2022-10-24 date: 2024-10-04 date: 2025-02-10 date: 2024-04-19 date: 2024-04-19 name: Hull University Teaching Hospitals NHS Trust class: OTHER_GOV briefSummary: Cough has previously been described by the type of cough you have ie such as wet, dry, and chesty, and also by its features such as how often you are coughing its,intensity, and severity, but never has the varying patterns of cough been studied in any detail and it could be that the pattern of the cough is closely related to patient-perceived intensity, frequency and most importantly severity. Cough is a symptom and like any other symptom (such as pain) the severity of it can only be gauged by the patient experiencing it.
We have created a one-page brand newl questionnaire that shows 4 distinct cough patterns that we believe exist and an empty field designed so that patients can record a pattern of cough they experience which is not already a choice on the questionnaire. The questionnaire also records patients' experience of how frequent, and intense, the cough is, and how it disrupts their lives, on a 1-10 scale (Visual analogue scale), the sum of these scores is collated and this gives us a severity score. The first phase of the project is to determine whether 30 Chronic cough patients understand the questionnaire, and are able to complete it with little direction, and if the cough patterns we identified encompassed all pattern types. second part of the study is to look at how repeatable the questionnaire is when completed over a 6 week period. conditions: Chronic Cough studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ESTIMATED measure: The primary objective of the study is to characterize and identify the different patterns of cough in chronic cough patients measure: measure of cough severity measure: describe any correlation between severity of cough and cough pattern measure: reproducibility of questionnnare sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Redspiratory Medicine, First Floor, Daisy Building, Castle Hill Hospital status: RECRUITING city: Cottingham state: East Yorkshiure zip: HU16 5JQ country: United Kingdom name: Caroline Wright role: CONTACT phone: 01482624067 email: c.wright@hull.ac.uk name: Rachel H Thompson, Bsc role: CONTACT phone: 01482 461800 phoneExt: Thompson email: r.h.thompson@hull.ac.uk name: Caroline Wright, Bsc role: PRINCIPAL_INVESTIGATOR lat: 52.50243 lon: -0.7554 hasResults: False
nctId: NCT06376435 id: HBHQ-CTIT-RWS briefTitle: A Multicentre Real-world Study of Heptapopal Ethanolamine Tablets in Concurrent/Sequential Radioimmunoinduced Thrombocytopenia overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2026-07-01 date: 2026-07-01 date: 2024-04-19 date: 2024-04-19 name: Hebei Medical University Fourth Hospital class: OTHER briefSummary: The objective of this study was to observe and evaluate the efficacy and safety of hexapopal ethanolamine tablets in the treatment of synchronous/sequential radioimmunoinduced thrombocytopenia in the real world.
This study will retrospectively and prospectively collect real-world data related to investigational drugs, and will observe 500 patients to observe the diagnosis and treatment pattern of radiochemo-induced thrombocytopenia. The study included a screening period (no more than one week) and a treatment period (at least two cycles).Participants meeting protocol inclusion criteria were defined as having platelet values \< 100×109/L during radioimmunotherapy. conditions: Cancer, Therapy-Related studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 500 type: ESTIMATED name: Herombopag Olamine Tablets measure: The proportion of patients recovered to 100×109/L measure: The proportion of patients recovered to 75×109/L measure: Time for platelet recovery to 100×109/L measure: Proportion of patients with treatment delay or dose reduction measure: TRAE sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06376422 id: EU-CT-2023-508271-36-00 briefTitle: Sterile Allogeneic Spongioflex® Allograft as Partial Meniscal Replacement After Incomplete Meniscal Loss overallStatus: RECRUITING date: 2024-05-01 date: 2029-04-30 date: 2031-04-30 date: 2024-04-19 date: 2024-04-19 name: Privatpraxis für Knie- und Schulterchirurgie class: OTHER briefSummary: The goal of this clinical trial is to learn if partial meniscal replacement can prevent or postpone total meniscal replacement, in adult patients (female/male) with partial meniscal loss. The main questions it aims to answer are: