hackint0sh/New-Dataset huggingface dataset:
The proposed study is a pilot randomized controlled trial of 30 patients with ALD who received a liver transplant; 15 will be randomized to receive a 10-week CM intervention while 15 will receive treatment as usual (TAU or control). Subjects will be asked to complete 12 study visits (including Screening and Baseline Visits) that will last 1 to 2 hours each depending on the visit. All visits will be completed via Zoom. Study staff will instruct participants on how to use Zoom, if necessary. During the Screening and Baseline Visits, subjects will be: 1) asked to provide a urine test and blood draw, 2) complete the SCID-5 AUD, a semi-structured interview guide for making the major DSM-5 diagnoses, 3) complete the Iowa Gambling Test which looks at decision-making skills, 4) complete a survey that looks at the subject's quality of life after liver transplant, 4) review how much alcohol the subject has consumed in the last 30 days, 5) and if the subject has received any current AUD treatments. Once the Screening and Baseline visits are completed, subjects will be randomized to either the CM group or the TAU group. During the weekly visits, subjects will be asked to provide blood and urine samples and will be asked if they have had any alcohol since their last visit. All subjects will receive $20 for completing the visits. For those in the CM group, subjects will also receive a CM reward for negative urine and/or blood tests, depending on which results we receive first-with rewards ranging from $5 to $80 depending on the week. Additionally, during weeks 1, 5, and 10, those in the CM group will also complete the Client Satisfaction Questionnaire-8 to assess client satisfaction with CM and complete a semi-structured interview about the CM protocol as well as CM acceptability and feasibility. conditions: Alcohol Use Disorder conditions: Alcohol; Liver conditions: Post Liver Transplant conditions: Contingency Management conditions: Alcohol Liver Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Contingency Management measure: Number of Non-Drinking Days measure: Patient-Reported Outcomes Measurement Information System (PROMIS® 29+2 Profile v2.1 (PROPr)) measure: Client Satisfaction Questionnaire-8. sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06304454 id: P5_BG briefTitle: Board Games at Kindergarten (5 Years Old) to Improve Cognitive and Emotional Processes overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-15 date: 2024-02-29 date: 2024-03-15 date: 2024-03-12 date: 2024-03-12 name: Brain In Game scientific-technical service class: OTHER briefSummary: Cognitive (i.e. executive functions, memory) and socio-emotional (i.e. affection recognition) processes emerges at first years. These processes have been frequently related to adequate academic performance in the scientific literature (Passolunghi et al, 2015). Current research aimed at training cognitive processes found promising results using board game as a cognitive tool in children (Passolunghi \& Costa, 2016). Considering the growing interest of teachers in this playful and possibly educational, cognitive and socio-emotional resource, a game program for these purposes has been designed to be used in kindergarten classrooms.
The main aim of the present study is to test the efficacy of a cognitive and emotional training program in the classroom based on board games in kindergarten students (5 years old). For this, there will be an experimental group that will carry out the cognitive and emotional game program in the classroom implemented by the teachers of the participating centers, and a control group that will be on board games that do not directly activate cognitive and emotional processes. At the end of the interventions, the groups will be compensated by carrying out inversely both board game programs. The classes will be randomly assigned to an experimental group and a passive control group. conditions: Kindergarten Children studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Cluster RCT primaryPurpose: PREVENTION masking: DOUBLE maskingDescription: Double (outcomes assessor and participants) whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 26 type: ACTUAL name: Board game intervention measure: Visual Memory measure: Processing speed and inhibition measure: Affect recognition measure: Hollingshead Index (Hollingshead, 1975) measure: CHEXI (Giménez et al. 2022) sex: ALL minimumAge: 5 Years maximumAge: 6 Years stdAges: CHILD facility: Faculty of Education, Psychology and Social Work; University of Lleida city: Lleida zip: 25001 country: Spain lat: 41.61674 lon: 0.62218 hasResults: False
nctId: NCT06304441 id: IPVO briefTitle: Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer overallStatus: RECRUITING date: 2024-03 date: 2025-03 date: 2026-03 date: 2024-03-12 date: 2024-03-12 name: Guangzhou Medical University class: OTHER briefSummary: Intrathecal chemotherapy is one of the mainstay treatment options for leptomeningeal metastases. Pemetrexed is one of the first-line chemotherapeutic agents for non-squamous non-small cell lung cancer (NSCLC). Since 2017, intrathecal pemetrexed has shown good efficacy for patients with leptomeningeal metastases from NSCLC. It has been recommended as the preferred drug for intrathecal chemotherapy by the Chinese Society of Clinical Oncology (CSCO) guidelines. Tyrosine kinase inhibitors (TKIs) play a promising role in the treatment of non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations. Due to its small molecule properties, it can effectively penetrate the central nervous system barrier and deliver an effective antitumor effect. An international multi-center clinical study published in 2019 confirmed that double-dose of osimertinib showed significant improvement in leptomeningeal metastases from NSCLC with EGFR exon 19 deletion or exon 21 L858R/T790M mutation. It makes TKIs the mainstay of treatment for patients with EGFR-mutant NSCLC with leptomeningeal metastases. However, whether third-generation small molecule TKI drugs (e.g. 'osimertinib') combined with intrathecal pemetrexed could benefit patients with LM from EGFR- mutant NSCLC remains undetermined. conditions: Leptomeningeal Metastasis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Osimertinib name: Pemetrexed measure: Clinical response rate measure: Overall survival measure: Incidence of treatment-related adverse events sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Third People's Hospital of Huizhou (Huizhou Hospital of Guangzhou Medical University) status: RECRUITING city: Huizhou state: Guangdong country: China name: Zhenyu Pan role: CONTACT phone: +8615804302753 email: dr-zypan@163.com name: Guozi Yang role: CONTACT phone: +8615804302755 email: guoziyang_1982@163.com lat: 23.11147 lon: 114.41523 hasResults: False
nctId: NCT06304428 id: Pro00114580 briefTitle: Prevention of Injury in Skilled Nursing Facilities Through Optimizing Medications acronym: PRISM overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2028-07-01 date: 2028-07-01 date: 2024-03-12 date: 2024-03-12 name: Duke University class: OTHER name: Patient-Centered Outcomes Research Institute name: Hebrew SeniorLife name: Brown University name: The American Health Care Association name: University of North Carolina, Chapel Hill briefSummary: The goal of this clinical trial is to compare three care models for optimizing medications and preventing falls with broken bones in patients receiving rehabilitation after a hospitalization for a broken bone.
This study has three aims. See Detailed Description for more details. This ClinicalTrials.gov record represents the Comparative Effectiveness Aim of the protocol. conditions: Accidental Falls/Prevention and Control conditions: Osteoporosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: PREVENTION masking: NONE count: 3780 type: ESTIMATED name: Deprescribing Care Model name: Bone Health Service Model name: Injury Prevention Service Model measure: Injurious falls measure: Number of patients who initiate treatment for osteoporosis measure: Medication Possession Ratio during follow-up, as measured by EHR and Medicare claims measure: Number of patients who had deprescribing ordered measure: Modified Drug Burden Index during follow-up, as measured by EHR and Medicare claims measure: Patient medication side effect burden, measured via Living with Medicines Questionnaire (LMQ3). measure: Patient falls self-efficacy (i.e. fear of falling), measured via Falls Efficacy Scale measure: Patient pain, measured via Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference Short Form measure: Patient depression, measured via Patient Health Questionnaire survey (PHQ-8) measure: Patient anxiety, measured via PROMIS anxiety short form survey measure: Patient sleep, measured via PROMIS sleep disturbance short form sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT hasResults: False
nctId: NCT06304415 id: CIRB2023/2651 briefTitle: Elevated Lipoprotein(a) in Hospital Staff acronym: LPACO overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2035-12-01 date: 2036-12-31 date: 2024-03-12 date: 2024-03-13 name: Changi General Hospital class: OTHER briefSummary: The objective of this study is to investigate the prevalence of elevated Lp(a) in the working general population. conditions: Hypercholesterolemia conditions: Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia conditions: Cardiovascular Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2800 type: ESTIMATED measure: Distribution and prevalence of elevated Lipoprotein(a) measure: Correlation of lipoprotein(a) with cardiovascular outcomes measure: Genetic variants of lipoprotein(a) and cardiovascular outcomes atherosclerotic events sex: ALL minimumAge: 21 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clinical Trials & Research Unit city: Singapore zip: 529889 country: Singapore lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06304402 id: 7978-GOA briefTitle: Comparing Shoulder Stretching and Percussive Massage on Shoulder Rotation and Attack Speed in Female Volleyball Players overallStatus: RECRUITING date: 2024-03-10 date: 2024-05-01 date: 2024-06-01 date: 2024-03-12 date: 2024-04-22 name: Dokuz Eylul University class: OTHER briefSummary: This study aims to investigate the acute effects of PNF modified sleeper stretches and percussive massage treatment on shoulder rotation movements and attack speed in female volleyball players and compare these applications. conditions: Sports Physical Therapy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 56 type: ESTIMATED name: The Percussive Massage Treatment name: The Proprioceptive Neuromuscular Facilitation Stretching measure: Shoulder internal rotation range of motion measure: Attack Speed sex: FEMALE minimumAge: 14 Years maximumAge: 40 Years stdAges: CHILD stdAges: ADULT facility: Dokuz Eylul University, School of Physical Therapy and Rehabilitation status: RECRUITING city: İzmir state: Balçova zip: 35340 country: Turkey name: Gonca Sahiner, PhD role: CONTACT lat: 38.41273 lon: 27.13838 hasResults: False
nctId: NCT06304389 id: BLUELIGHT-VNS briefTitle: Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy acronym: BLUELIGHTVNS overallStatus: RECRUITING date: 2023-07-01 date: 2023-07-01 date: 2026-04 date: 2024-03-12 date: 2024-03-12 name: Cliniques universitaires Saint-Luc- Université Catholique de Louvain class: OTHER briefSummary: Vagus nerve stimulation (VNS) is an adjunctive treatment for refractory epilepsy. Although widely used, there is still a substantial number of patients with insufficient response. Light, and particularly blue light, can stimulate alertness, attention and cognition through modulation of anatomical targets which are common to the vagal afferent network. This project aims at understanding how exposure to blue enriched light may influence VNS effects in patients with refractory epilepsy by exploring the modulation of a series of biomarkers of VNS action. This could possibly lead to new therapeutic strategies to increase efficacy of VNS. conditions: Refractory Epilepsy studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients with refractory epilepsy (divided in non responders \& responders), and healthy subjects primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 34 type: ESTIMATED name: electroencephalography, electrocardiogram, pupillometry, evoked potentials, light administration name: transcutaneous vagus nerve stimulation, electroencephalography, pupillometry, electrocardiogram, light administration measure: Effect of blue light on VNS biomarkers measure: Effect of blue light on VNS biomarkers measure: Effect of blue light on VNS biomarkers sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Cliniques Universitaires Saint Luc status: RECRUITING city: Woluwe-Saint-Lambert zip: 1200 country: Belgium name: Inci Cakiroglu, Phd student role: CONTACT phone: +32470612917 email: inci.cakiroglu@uclouvain.be name: Inci Cakiroglu, Phd student role: SUB_INVESTIGATOR lat: 50.84389 lon: 4.42912 hasResults: False
nctId: NCT06304376 id: OMFS/FSDC002 briefTitle: Evaluation of Shell Technique in Secondary Alveolar Cleft Grafting acronym: Alveolar cleft overallStatus: COMPLETED date: 2022-03-12 date: 2023-11-30 date: 2024-02-22 date: 2024-03-12 date: 2024-03-12 name: October 6 University class: OTHER name: Ministry of Health, Kuwait briefSummary: This study aims to evaluate the sufficiency of Khoury shell technique for reconstruction of alveolar cleft. Khoury technique was carried out using cortical bone shell fixed away from alveolar bone using two micro-screws, which was harvested from anterior iliac bone crest. The gap between the shell cortical bone and the native alveolar bone was filled by cancellous bone which was harvested from anterior iliac crest bone. The whole graft was covered by collagen membrane. The volumetric bone gain of the defect was determined via CBCT. conditions: Alveolar Cleft conditions: Alveolar Ridge Cleft studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 14 type: ACTUAL name: Alveolar ridge grafting measure: Volumetric bone gain measure: Eruption of the tooth in the cleft sex: ALL minimumAge: 7 Years maximumAge: 14 Years stdAges: CHILD facility: Ministry of Health, Farwaniya Hospital city: Al Farwānīyah zip: 81004 country: Kuwait lat: 29.2775 lon: 47.95861 hasResults: False
nctId: NCT06304363 id: Braining booster briefTitle: Braining - Evaluation of Acute Effects of Physical Exercise overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2025-12-31 date: 2026-12-31 date: 2024-03-12 date: 2024-03-12 name: Region Stockholm class: OTHER_GOV name: Karolinska Institutet briefSummary: "Braining" is a clinical method for physical exercise as adjunctive therapy in psychiatric care. The core components are personnel-led group training sessions and motivating contact with psychiatric staff, as well as measurements and evaluations before and after a training period.
The scientific purpose of this study is to investigate immediate and short-term effects of a booster-session of several Braining classes. conditions: Psychiatric Disorder studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Braining measure: Anxiety Visual Analogue Scale (VAS) measure: Beck Anxiety Inventory BAI measure: Montgomery-Åsberg Depression Rating Scale MADRS measure: High sensitivity C-reactive protein hsCRP measure: Brain-derived neurotrophic factor BDNF measure: Telomerase activity measure: Motivational factors of continued exercise sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Region Stockholm, Psykiatri Sydväst (Psychiatric Clinic Psychiatry Southwest) city: Stockholm zip: 14186 country: Sweden lat: 59.33258 lon: 18.0649 hasResults: False
nctId: NCT06304350 id: SGHDOT-24-20 briefTitle: Pembrolizumab Combined With Preoperative Chemotherapy (Albumin Paclitaxel+Carboplatin) Neoadjuvant Therapy for Resectable Locally Advanced (Stage II/III) Esophageal Squamous Cell Carcinoma overallStatus: RECRUITING date: 2024-02-17 date: 2026-02-25 date: 2026-12-31 date: 2024-03-12 date: 2024-03-13 name: Tongji University class: OTHER briefSummary: This study is a prospective, single center, open label, single arm clinical study. Select resectable locally advanced (cT3-4aN0M0, cT1-3N1-2M0, cII/III stage) esophageal cancer with pathological diagnosis of squamous cell carcinoma for inclusion, receive pembrolizumab combined with platinum containing dual drug (albumin paclitaxel+carboplatin) treatment for 2 courses, and undergo surgery. After surgery, continue pembrolizumab immunotherapy. Using pCR as the main endpoint of the study conditions: Esophageal Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 25 type: ESTIMATED name: Combination of pembrolizumab and platinum containing dual drugs measure: Pathological complete remission (pCR) measure: Major pathological remission (MPR) measure: R0 resection rate measure: Progression free survival (PFS) measure: Total survival time (OS) measure: Safety (incidence of adverse drug reactions) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai General Hospital status: RECRUITING city: Shanghai state: Shanghai zip: 200080 country: China name: Jiang Fan, MD role: CONTACT phone: 02163240090 email: fan_jiang@tongji.edu.cn name: Jiang Fan, MD role: PRINCIPAL_INVESTIGATOR lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06304337 id: YXLL-KY-2023(162) briefTitle: Application of New Oropharyngeal Airway Management in Patients Undergoing Painless Gastroenteroscopy overallStatus: NOT_YET_RECRUITING date: 2024-03-03 date: 2024-10-10 date: 2025-03-03 date: 2024-03-12 date: 2024-03-12 name: Qianfoshan Hospital class: OTHER briefSummary: The objective of this study was to investigate the application of new oropharyngeal airway management in patients undergoing painless gastroenteroscopy.To see if it can really solve the problem of airway obstruction during anesthesia.The incidence of hypoxia (Spo2\<90%, t\>10s) and severe hypoxia (Spo2\<85%) during anesthesia and sedation, as well as the incidence of cough and laryngeal spasm, as well as the dose, endoscopist satisfaction, and the incidence of various adverse events were observed.To accumulate clinical experience and reference of anesthesia in obese patients. conditions: Airway Management studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 228 type: ESTIMATED name: New oropharyngeal airway group measure: Incidence of hypoxia (Spo2<90%,t>10s) and severe hypoxia (Spo2<85%) during anesthetic sedation measure: The incidence of choking, reflux aspiration and laryngeal spasm were recorded measure: The dose of additional drugs during the operation measure: Endoscopist satisfaction measure: Record adverse events that occur throughout the process sex: ALL minimumAge: 18 Years maximumAge: 95 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06304324 id: 18/2023 briefTitle: Dexmedetomidine vs Dexamethasone in Popliteal Nerve Block overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-03-31 date: 2025-04-30 date: 2024-03-12 date: 2024-03-12 name: Poznan University of Medical Sciences class: OTHER briefSummary: Effect of Perineural Dexmedetomidine vs. Dexamethasone on the duration of popliteal nerve block for Anesthesia After Pediatric ankle/foot surgery. conditions: Ankle Disease conditions: Ankle Injuries and Disorders conditions: Foot Injury conditions: Foot Diseases studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: 0.9% Sodium chloride name: 0.1mg/kg Dexamethasone name: 0.05ug/kg Dexmedetomidine measure: time to the first need of opiate following the procedure measure: Face, Legs, Activity, Cry, Consolability (FLACC) Behavioral Scale measure: Face, Legs, Activity, Cry, Consolability (FLACC) Behavioral Scale measure: Face, Legs, Activity, Cry, Consolability (FLACC) Behavioral Scale measure: Face, Legs, Activity, Cry, Consolability (FLACC) Behavioral Scale measure: Face, Legs, Activity, Cry, Consolability (FLACC) Behavioral Scale measure: Face, Legs, Activity, Cry, Consolability (FLACC) Behavioral Scale measure: Face, Legs, Activity, Cry, Consolability (FLACC) Behavioral Scale measure: Face, Legs, Activity, Cry, Consolability (FLACC) Behavioral Scale measure: Face, Legs, Activity, Cry, Consolability (FLACC) Behavioral Scale measure: Neutrophil-to-lymphocyte ratio measure: Platelet-to-lymphocyte ratio measure: Platelet-to-lymphocyte ratio measure: Time to mobilization sex: ALL minimumAge: 3 Months maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Department of Spine Diseases and Pediatric Orthopedics, University of Medical Sciences, Poznań, Poland city: Poznań state: Wielkopolska zip: 61-545 country: Poland lat: 52.40692 lon: 16.92993 hasResults: False