hackint0sh/New-Dataset huggingface dataset:
2. NIRAF coronary artery signal level is a predictor of plaque progression on a per patient, per artery, or per lesion basis. conditions: Cardiovascular Diseases conditions: Coronary Artery Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 40 type: ESTIMATED name: OCT-NIRAF measure: Plaque size estimation using OCT-NIRAF measure: Plaque progression estimate using OCT-NIRAF sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Massachusetts General Hospital city: Boston state: Massachusetts zip: 02114 country: United States name: Nitasha Bhat, MD role: CONTACT phone: 617-724-4515 email: Tearneylabtrials@partners.org lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06374485 id: AU409-LEES-2021-03 briefTitle: Study of AU409 Capsule in Advanced Hepatocellular Carcinoma Patients Who Failed Standard Treatment overallStatus: RECRUITING date: 2024-04-12 date: 2026-02-28 date: 2026-08-28 date: 2024-04-18 date: 2024-04-18 name: Lee's Pharmaceutical Limited class: INDUSTRY briefSummary: This study is a Phase I, dose-escalation study of AU409 in advanced hepatocellular carcinoma patients who failed standard treatment. A '3+3' dose-escalation design will be utilized to gradually increase the dose of AU409, aiming to assess the safety, tolerability, pharmacokinetics, and preliminary antitumor efficacy of multi-dose AU409 in patients with advanced HCC. conditions: Advanced Hepatocellular Carcinoma studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 18 type: ESTIMATED name: AU409 capsules measure: Dose Limiting Toxicity measure: Maximum Tolerated Dose measure: Recommended Phase 2 Dose measure: Objective Response Rate measure: Disease Control Rate measure: Duration of Response measure: Progression-free Survival measure: Overall Survival sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Clinical Oncology, Queen Mary Hospital status: RECRUITING city: Hong Kong country: China name: Chi Leung Chiang role: PRINCIPAL_INVESTIGATOR name: Albert Chan role: SUB_INVESTIGATOR name: Aya El HELALI role: SUB_INVESTIGATOR lat: 22.39407 lon: 114.13737 hasResults: False
nctId: NCT06374472 id: IRB00001194 briefTitle: Surgical Treatment of Fractures of the Dorso-lombar Spine overallStatus: COMPLETED date: 2018-01-01 date: 2022-01-01 date: 2022-01-01 date: 2024-04-18 date: 2024-04-18 name: Ibn Jazzar Hospital class: OTHER briefSummary: Trauma to the thoracolumbar spine is responsible for potentially serious lesions, most often involving the functional prognosis in the short, medium and long term, and rare The frequency of these traumas is explained by falls from high places, especially during work accidents or suicide attempts, but also by the perpetual increase in accidents on public roads ly the vital prognosis conditions: Spine Fracture studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 80 type: ACTUAL name: Osteosynthesis measure: Age (in years) measure: Sex measure: Neurological status ( Frenkel classification) sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: IBN jazzar hospital city: Kairouan zip: 3190 country: Tunisia lat: 35.6781 lon: 10.09633 hasResults: False
nctId: NCT06374446 id: 22-172 briefTitle: Effect of Virtual Reality in Patients With Long Covid-19 overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2024-06-15 date: 2024-06-30 date: 2024-04-18 date: 2024-04-18 name: Istinye University class: OTHER briefSummary: SARS-CoV-2 was first detected in Wuhan, Hubei Province, China, in late 2019. It is a highly contagious virus that has been reported to occur in humans and is said to cause pneumonia.
Covid-19 infection is transmitted through droplets during coughing and sneezing and through contact with the mouth, nose or eyes after contaminated hands. The most obvious symptoms of Covid-19 symptoms include cough, dyspnea and fever. Covid-19, which can also be seen asymptomatic, is in intensive care it may be severe enough to require hospitalization, cause multiple organ failure and even death it could be. Musculoskeletal symptoms such as fatigue, myalgia, and arthralgia are common with Covid-19 are the symptoms. The first case in Turkey was reported on March 11, 2020.
No study was found in the literature investigating the effect of virtual reality application on fatigue, functional capacity and respiratory function in long-term Covid-19 patients. The purpose of this study; To investigate the effect of virtual reality application on fatigue, functional level and respiratory function in long-term Covid-19 patients. conditions: COVID-19 studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 56 type: ESTIMATED name: Classical Treatment name: Virtual Reality Combined with Classical Treatment name: Virtual Reality name: Control Group measure: Fatigue measure: Kinesiophobia measure: Evaluation of Respiratory Function measure: Shuttle Walking Test measure: Endurance Shuttle Walking Test measure: Sit and Reach Test measure: Peripheral Muscle Strength measure: The Nottingham Health Profile measure: Dyspnea measure: Energy Consumption measure: Posture Analysis measure: Covid-19 Yorkshire Performance measure: FACIT Fatigue Scale sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06374433 id: PREDICOM-01 briefTitle: Investigating the Plasticity of Human Predictive Coding Through Neuromodulation acronym: PREDICOM overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-04-30 date: 2026-12-31 date: 2024-04-18 date: 2024-04-18 name: Università Vita-Salute San Raffaele class: OTHER name: Alessia Santoni name: Sara Stottmeier name: Klara Hemmerich name: Giuseppe Di Dona name: Luigi Ferini-Strambi briefSummary: The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults. conditions: Human Brain and Cognition studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 210 type: ESTIMATED name: Occipital tACS at IAF-2Hz name: Occipital tACS at IAF+2Hz name: Frontal tACS at 4-7 Hz name: Occipital tRNS name: Frontal tRNS name: Sham/placebo tACS name: Sham/placebo tRNS measure: Behavioral measures sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT hasResults: False
nctId: NCT06374420 id: MD.21.11.564 briefTitle: Small Airway Disease And Bronchial Hyperreactivity In Patients With Post Acute Covid-19 Syndrome overallStatus: COMPLETED date: 2021-09-01 date: 2023-09-01 date: 2024-04-01 date: 2024-04-18 date: 2024-04-19 name: Mansoura University class: OTHER briefSummary: The aim of this work is to estimate the frequency of small airway disease and/or the bronchial hyperreactivity in follow up of postacute covid survivors. conditions: COVID-19 studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 100 type: ACTUAL measure: investigating pulmonary sequelae of covid-19. measure: investigating pulmonary sequelae of covid-19. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mansoura University city: Mansoura state: Dakhlia zip: 050 country: Egypt lat: 31.03637 lon: 31.38069 hasResults: False
nctId: NCT06374381 id: 854990 briefTitle: PEACE for ImPACT Study overallStatus: ENROLLING_BY_INVITATION date: 2023-12-01 date: 2027-11 date: 2027-11 date: 2024-04-18 date: 2024-04-18 name: University of Pennsylvania class: OTHER name: Institute of Education Sciences name: Michigan State University briefSummary: Investigators will test the impact of the PEACE implementation toolkit and determine the level of implementation support needed to improve early intervention providers use of caregiver coaching with families of young children with autism who receive early intervention services. The study will also assess caregiver and child outcomes for families receiving caregiver coaching and the cost effectiveness of the PEACE implementation toolkit. The investigators will enroll 200 early intervention providers, and 400 parent-child dyads. conditions: Autism Spectrum Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Outcome assessors will be masked to randomization condition. whoMasked: OUTCOMES_ASSESSOR count: 600 type: ESTIMATED name: PEACE Online Resources name: PEACE Weekly Group Facilitation name: PEACE Weekly Individual Facilitation measure: Parent Empowerment and Coaching in Early Intervention (PEACE) Caregiver Coaching Fidelity Tool measure: Parenting Interactions with Children: Checklist of Observations Linked to Outcomes (PICCOLO) measure: Autism Impact Measure (AIM) measure: Social Communication Checklist (SCC) measure: Confusion, Hubbub, and Order Scale (CHAOS) measure: Acceptability, Appropriateness, and Adoption measure measure: Qualitative Interview sex: ALL minimumAge: 12 Months stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Center for Mental Health city: Philadelphia state: Pennsylvania zip: 19104 country: United States lat: 39.95233 lon: -75.16379 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-11-30 uploadDate: 2024-04-12T13:20 filename: Prot_SAP_000.pdf size: 508769 hasResults: False
nctId: NCT06374368 id: JID-SURG briefTitle: Small Bowel Diversion overallStatus: ACTIVE_NOT_RECRUITING date: 2019-05-01 date: 2024-12-31 date: 2024-12-31 date: 2024-04-18 date: 2024-04-24 name: University of Ostrava class: OTHER name: Institute for Clinical and Experimental Medicine name: Vitkovice Hospital briefSummary: In an effort to replicate metabolic surgery's durable results in metabolic disease while minimizing its risks, two innovative methods has been created. Two surgical methods to create a bowel-to-bowel anastomosis, similar to the type used in current metabolic surgeries. It be to create a jejuno-ileal, side-to-side anastomosis and jejunocolic side-to-side anastomosis. The side-to-side jejuno-ileal anastomosis and side-to-side jejunocolic anastomosis provides two routes for ingested food. The new, shorter route has a malabsorptive effect similar to that seen in Roux en-Y gastric bypass (RYGB) and biliopancreatic diversion (BPD) - procedures which leads to weight loss. Additionally, delivery of non-absorbed macronutrients to the distal ileum, or transverse colon can enhance incretin effect and improve Type 2 Diabetes parameters. However, the native route is also preserved, which theoretically reduces the risk of malnutrition, diarrhea, and metabolic derangements seen in other metabolic surgeries.The side-to-side jejuno-ileal anastomosis was already tested in the Pilot Study of the GI Windows Self-Forming Magnetic (SFM) Anastomosis Device for Crea-tion of an Incisionless Small Bowel Bypass for Treatment of Obesity and Diabetes in year 2015 (15). The results of this study demonstrated the safety of this approach without seri-ous adverse events. This non-surgical approach resulted in Significant weight loss, favorable changes in insulin and incretin responses to a mixed meal and Significant improvement in A1C in T2DM (16).In summary, metabolic disease is a growing pandemic with suboptimal clinical solutions. The surgical side-to-side jejuno-ileal anastomosis and side-to-side jejuno-colic anastomosis without gastrectomy potentially represents a new class of therapy that may produce durable clinical results generally associated with surgery while minimizing its attendant risks. conditions: Obesity conditions: Type2 Diabetes studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 30 type: ACTUAL name: jejuno-ileal diversion name: jejuno-colic diversion measure: Total body weight loss measure: Glycated hemoglobin loss measure: Diabetes medication loss measure: Total cholesterol loss measure: Low density lipoprotein loss measure: High density lipoprotein loss measure: Leptin metabolism evaluation measure: Adiponectin metabolism evaluation measure: Change from baseline quality of life-Lite measure: Change from baseline quality of life - Sort Form Survey sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Ostrava, Faculty of Medicine city: Ostrava country: Czechia lat: 49.83465 lon: 18.28204 hasResults: False
nctId: NCT06374355 id: Semibranch_Retro briefTitle: Semibranch Registry - Retrospective overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-04 date: 2030-10 date: 2024-04-18 date: 2024-04-22 name: University Hospital Muenster class: OTHER briefSummary: The goal of this registry is to evaluate the semibranch in branched endovascular arotic repair, which is a new tool in endovascular branched aortic repair. conditions: Aortic Aneurysm conditions: Endovascular Aortic Repair conditions: Stent-Graft Endoleak studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 100 type: ESTIMATED name: Semibranch CMD branched aortic stentgraft measure: Freedom from target vessel instability measure: Mortality measure: Technical success measure: Morbidity measure: Freedom of Endoleak type I and III measure: Long term mortality measure: Branch patency sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Muenster University Hospital city: Münster country: Germany lat: 51.96236 lon: 7.62571 hasResults: False
nctId: NCT06374342 id: SO01-TK-SUBSTITUTES briefTitle: BONE SUBSTITUTES OUTCOMES overallStatus: RECRUITING date: 2021-09-16 date: 2026-09-16 date: 2032-09-30 date: 2024-04-18 date: 2024-04-18 name: Teknimed class: INDUSTRY briefSummary: A Post-Market Clinical Follow-Up (PMCF) Study to collect clinical data on safety and performance of all TEKNIMED Bone Substitute range of products: CERAFORM, TRIHA+, NANOGEL, and all their private labels.
The study is a retrospective and prospective global, single arm, non-controlled, multicentric, prospective observational study. Patients will be followed as per local standard medical care of the sites. conditions: Bone Resorption studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 425 type: ESTIMATED name: Bone defect name: Spine fusion name: Cage filling measure: Successful bone repair measure: Alleviation of Pain measure: Bone reconstruction measure: Well-being measure: Patient satisfaction sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pôle Rachis Hôpital Privé d'Eure et Loir status: RECRUITING city: Mainvilliers state: Eure Et Loir zip: 28300 country: France name: Jean MEYBLUM, MD role: CONTACT email: jeanmeyblum@hotmail.com name: Jean MEYBLUM, MD role: PRINCIPAL_INVESTIGATOR lat: 48.45003 lon: 1.45607 facility: Hôpital Joseph Ducuing status: RECRUITING city: Toulouse state: Haute Garonne zip: 31000 country: France name: Gérard GIORDANO, MD role: CONTACT email: ortho.giordano@gmail.com name: Gérard GIORDANO, MD role: PRINCIPAL_INVESTIGATOR lat: 43.60426 lon: 1.44367 facility: Clinique Médipole Garonne status: RECRUITING city: Toulouse state: Haute Garonne zip: 31100 country: France name: Dominique VARDON, MD role: CONTACT email: dr-dominique.vardon@orange.fr name: Dominique VARDON, MD role: PRINCIPAL_INVESTIGATOR lat: 43.60426 lon: 1.44367 facility: CHRU Brabois status: RECRUITING city: Nancy state: Meurthe Et Moselle zip: 54000 country: France name: Didier MAINARD, MD role: CONTACT email: didier.mainard@univ-lorraine.fr name: Didier MAINARD, MD role: PRINCIPAL_INVESTIGATOR lat: 48.68439 lon: 6.18496 facility: Clinique du Pré status: RECRUITING city: Le Mans state: Sarthe zip: 72000 country: France name: Jean-Patrick RAKOVER, MD role: CONTACT phone: 02 43 77 54 21 email: jeanpatrickrakover@me.com name: Jean-Patrick RAKOVER, MD role: PRINCIPAL_INVESTIGATOR lat: 48.0 lon: 0.2 facility: OCM Klinik GmbH status: RECRUITING city: München state: Bavière zip: D-81369 country: Germany name: Markus SCHROEDEL, MD role: CONTACT email: Markus.schroedel@ocm-muenchen.de name: Markus SCHROEDEL, MD role: PRINCIPAL_INVESTIGATOR lat: 48.13743 lon: 11.57549 hasResults: False
nctId: NCT06374329 id: S68717 briefTitle: Effect of Interceptive Strategies on the Clinical Outcome of Impacted Maxillary Permanent Canines acronym: RCTcanines2 overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2026-08-01 date: 2027-08-01 date: 2024-04-18 date: 2024-04-24 name: Universitaire Ziekenhuizen KU Leuven class: OTHER name: Karolinska Institutet name: University of Copenhagen name: Palacky University name: The University of Hong Kong briefSummary: Canine impaction is a sign of abnormal dental development with potentially far-reaching consequences (such as significant root resorption and loss of lateral incisors. This compromises both aesthetics and function of the teeth, making the prediction of canine tooth impaction increasingly important. Interceptive orthodontic measures, such as extraction of deciduous canines or molars or maxillary expansion aim to create extra space in the dental arch, allowing the canines to position themselves better and normalizing their eruption pattern.
This study corresponds to the second phase of an RCT, based on the results of the first phase, published in July 2023 (S59030) (Willems G, Butaye C, Raes M, Zong C, Begnoni G, Cadenas de Llano-Pérula M. Early prevention of maxillary canine impaction: a randomized clinical trial. Eur J Orthod. 31;45(4):359-369). The first phase compared the effect of 3 interceptive strategies (expansion, extraction and no intervention) on the position of impacted maxillary canines, finding that maxillary expansion provides the most improvement on impacted canine position. In second phase, 8-year-old patients without posterior crossbite and lack of space in the dental arch are randomized to treatment with 'slow maxillary expansion with removable plates' or 'no treatment'. These groups are additionally compared with patients with a crossbite and lack of space, which always receive expansion treatment. All selected patients will be followed up for at least 18 months. The primary endpoint is to investigate the effect of maxillary expansion with removable plates on the position of maxillary canines prone to impaction during early mixed dentition, assessed on panoramic X-rays. The secondary endpoint is the assessment of the need for additional orthodontic treatment. conditions: Tooth Impaction conditions: Canine Teeth studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 75 type: ESTIMATED name: Interceptive Slow Maxillary Expansion with removable plates measure: Position of the impacted maxillary canine towards the dental midline (3^ML). measure: Need for subsequent interventions (extraction of deciduous or permanent teeth, other orthodontic interventions, surgical exposure) sex: ALL minimumAge: 7 Years maximumAge: 10 Years stdAges: CHILD hasResults: False
nctId: NCT06374316 id: 2302888 briefTitle: Air Purifiers in Classrooms for Infection Control - a Pilot Study overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-15 date: 2024-05-01 date: 2024-05-01 date: 2024-04-18 date: 2024-04-18 name: Norwegian Institute of Public Health class: OTHER_GOV name: SINTEF Health Research briefSummary: This study aims to investigate the acceptability and feasibility of deploying air purifiers equipped with HEPA (high-efficiency particulate air) filters in classrooms, to study air purifiers as an infection control measure. It will also evaluate the direct effect of air purifiers on air quality, comparing ceiling-mounted purifiers, portable purifiers and no purifier. conditions: Feasibility conditions: Acceptability studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: We will select schools for participation in arm 1 and 2, respectively, based on the feasibility of installing ceiling-mounted and placing portable air purifiers in each relevant classroom. In arm 3, all three classrooms will be equipped with both ceiling-mounted and portable air purifiers, as well as indoor air quality sensors.
Program 1) Week 1, 4, and 7: Ceiling-mounted ON, Week 2, 5, and 8: No purifier on, Week 3, 6, and 9: Portable ON. Program 2) Week 1, 4, and 7: Portable ON, Week 2, 5, and 8: Ceiling-mounted ON, Week 3, 6, and 9: No purifier on. Program 3) Week 1, 4, and 7: No purifier on Week 2, 5, and 8: Portable ON, Week 3, 6, and 9: Ceiling-mounted ON.
Each classroom will be assigned a computer-generated random number and will based on the ascending order of the random numbers be allocated to the three predetermined sequences of programs. primaryPurpose: OTHER masking: NONE count: 6 type: ACTUAL name: Ceiling-Mounted Air Purifiers name: Portable Air Purifiers name: Portable or Ceiling Mounted Air Purifiers measure: Effectiveness of air purifiers versus no air purifier on improving air quality in classrooms. measure: Effectiveness of ceiling mounted versus portable air purifier on improving air quality in classrooms. measure: Acceptability of having Air Purifiers in Classrooms measure: Untoward events when installing air purifiers in classrooms measure: Untoward events when running air purifiers in classrooms measure: How student absence data can be collected from existing school registration systems. measure: Response rate of class teachers to the study surveys. measure: Response rate of students/their guardians to study surveys. measure: Proportion of absence due to respiratory disease. measure: Absence frequency among students sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Norwegian Institute of Public Health city: Oslo country: Norway lat: 59.91273 lon: 10.74609 hasResults: False
nctId: NCT06374303 id: CHRBSS 00001940 briefTitle: Novel Intervention to Improve Food Insecurity Among Individuals With Opioid Use Disorder: A Randomized Clinical Trial overallStatus: COMPLETED date: 2022-04-19 date: 2023-11-20 date: 2023-11-20 date: 2024-04-18 date: 2024-04-18 name: University of Vermont class: OTHER briefSummary: The adverse consequences of illicit opioid use (e.g., overdose, premature death) are the focus of intensive research efforts. However, other serious health problems among individuals with opioid use disorder (OUD) have received far less attention. Food insecurity (FI) is 4-7 times greater among individuals with OUD than the general population. In addition to the increased healthcare utilization and costs, poor health outcomes, and adverse social consequences associated with FI in the general population, patients with co-occurring FI and OUD are at increased risk for licit and illicit drug use, sexual and drug risk behaviors, infectious disease, and a two-fold greater odds of premature death.
The NE+MD intervention was associated with significant improvements in household FI, with fewer NE+MD participants meeting criteria for FI vs. NE participants at all three assessment timepoints (p's\<.05). Retention rates were similar between the two groups (88% and 84% for NE+MD and NE conditions, respectively; p=.68). Intervention acceptability was also high, with NE+MD participants rating the enjoyment and convenience of the meals at 81 and 93, respectively (range: 0-100).