hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06348121 id: WK2024003 briefTitle: Impact of Probiotics on Children With ADHD overallStatus: NOT_YET_RECRUITING date: 2024-05-07 date: 2024-08-31 date: 2024-12-31 date: 2024-04-04 date: 2024-04-26 name: Wecare Probiotics Co., Ltd. class: INDUSTRY briefSummary: To evaluate the efficacy and safety of probiotic product WecProB as food supplements for the treatment of clinical symptoms in children with ADHD, in comparison with placebo. conditions: Attention Deficit Hyperactivity Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 80 type: ESTIMATED name: Probiotic measure: Clinical symptoms of ADHD sex: MALE minimumAge: 6 Years maximumAge: 14 Years stdAges: CHILD hasResults: False
nctId: NCT06348095 id: WK2024004 briefTitle: Effect of Probiotics on Viral Pneumonia overallStatus: NOT_YET_RECRUITING date: 2024-05-07 date: 2024-10-31 date: 2024-12-31 date: 2024-04-04 date: 2024-04-26 name: Wecare Probiotics Co., Ltd. class: INDUSTRY briefSummary: To evaluate the effectiveness and safety of compound probiotic in shortening the course of illness in children with viral pneumonia, in comparison with placebo. conditions: Viral Pneumonia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 72 type: ESTIMATED name: Probiotic name: Placebo measure: Respiratory syncytial virus (RSV) viral load sex: ALL minimumAge: 6 Months maximumAge: 3 Years stdAges: CHILD hasResults: False
nctId: NCT06348082 id: 2000036068 id: 1R18HS029812-01 type: AHRQ link: https://reporter.nih.gov/quickSearch/1R18HS029812-01 briefTitle: Project Women's Insomnia Sleep Health Equity Study (WISHES) acronym: Project WISHES overallStatus: NOT_YET_RECRUITING date: 2025-09 date: 2028-07 date: 2028-07 date: 2024-04-04 date: 2024-04-05 name: Yale University class: OTHER name: Department of Health and Human Services briefSummary: The purpose of this study is to achieve health and healthcare equity by implementing an equity-focused, mindfulness-based sleep intervention to reduce stress and sleep deficiency-related cardiometabolic disease burden in Black women. conditions: Insomnia conditions: Sleep Health conditions: Cardiometabolic Health studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Hybrid Type 1 effectiveness/implementation study using a pragmatic randomized controlled trial (RCT) with MBTI and a waitlist control. Participants will be randomly assigned by a computer-generated sequence to either the MBTI or waitlist control in a 1:1 ratio using permuted blocks stratified by age (2 strata: ≤50 or postmenopausal age \>51) with random block sizes of 2 or 4 to reduce predictability. primaryPurpose: SUPPORTIVE_CARE masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 340 type: ESTIMATED name: Mindfulness-based therapy for insomnia (MBTI) measure: Change in Insomnia Severity measure: Change in Perceived Stress measure: Acceptability of Intervention (AIM) measure: Feasibility of Intervention (FIM) measure: Treatment Fidelity sex: FEMALE minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Yale School of Nursing Biobehavioral Lab city: West Haven state: Connecticut zip: 06516 country: United States lat: 41.27065 lon: -72.94705 hasResults: False
nctId: NCT06348069 id: 2022-11-15783 briefTitle: Pharmacy-based PrEP for Young Women Who Sell Sex in Zimbabwe acronym: TOPAZ overallStatus: RECRUITING date: 2024-03-25 date: 2025-03-11 date: 2025-12-31 date: 2024-04-04 date: 2024-04-04 name: University of California, Berkeley class: OTHER name: Centre for Sexual Health and HIV/AIDS Research Zimbabwe (CeSHHAR Zimbabwe) name: University of California, San Francisco name: Liverpool School of Tropical Medicine briefSummary: Pharmacy-based PrEP for Young Women who Sell Sex in Zimbabwe is a cluster-randomized control trial and pilot study co-led by Dr. Euphemia Sibanda, Reader (Associate Professor) of Global Health and Epidemiology at Liverpool School of Tropical Medicine, UK and Research Director at the Centre for Sexual Health and HIV Research (CeSHHAR Zimbabwe) and Dr. Sandra McCoy, Professor of Epidemiology and Biostatistics at the University of California, Berkeley. The goal of the proposed study is to optimize, refine and pilot a pharmacy-based PrEP intervention for female sex workers (FSW) in Zimbabwe. Despite efforts to reach the most impacted and vulnerable populations with PrEP, retention rates, particularly among FSW in Africa, are very low. Relatively high levels of uptake indicate that FSW are interested in PrEP and ready to initiate it, but in most cases fewer than 50% of those who initiate return for medication refills by month 4. Pharmacy-based PrEP has the potential to address known barriers to PrEP retention among FSW such as stigma and access, and coupled with a small escalating incentive in the form of a gift card incentive, could also boost motivation for effective use of PrEP. conditions: Adherence, Medication conditions: HIV Prevention studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Groups (sites/clusters) are randomized to either the intervention (pharmacy-based PrEP refills plus gift card incentives) or the control (standard of care) and are followed and compared over time. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 200 type: ESTIMATED name: Pharmacy-based PrEP refill and gift voucher name: Control (Standard of care) measure: PrEP retention at 6 months measure: PrEP retention at 6 months among FSW who are 18-24 years of age measure: : PrEP retention at 6 months among participants who have remained active in sex work measure: FSW (overall) and FSW (18-24 years) patronage for PrEP services at pharmacies measure: HIV tests measure: HIV care referrals sex: ALL minimumAge: 16 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: CESHHAR Zimbabwe status: RECRUITING city: Harare zip: 0000 country: Zimbabwe name: Oppah Kuguyo role: CONTACT email: oppah.kuguyo@ceshhar.co.zw lat: -17.82772 lon: 31.05337 hasResults: False
nctId: NCT06348056 id: 2022-07-15499 briefTitle: A Comparison of the Metabolic Effects of Zinc-Amino Acid (ZnAA) Versus Zinc Gluconate overallStatus: RECRUITING date: 2024-01-22 date: 2024-08-30 date: 2024-12-31 date: 2024-04-04 date: 2024-04-08 name: University of California, Berkeley class: OTHER briefSummary: Food consumption affects zinc metabolism within the body. Lowe and colleagues demonstrated that zinc is directed out of plasma and into tissues, such as into the liver, postprandially . It is likely that zinc absorbed with a meal is directed to the liver via the portal circulation whereas that zinc taken in the fasted state is more readily directed to peripheral blood plasma. Zinc taken with food is more likely to be bound to components of the food matrix and, therefore, it is not absorbed as efficiently by Zip4 ionic zinc transporters in the upper gastrointestinal tract. Some of the zinc in the food matrix may, however, be co-absorbed with amino acids over the whole length of the small intestine . Co-absorption of zinc with amino acids may explain the greater effects of zinc taken with food on omega-6 fatty acid desaturation . The investigators propose that this effect may be maximized by providing supplemental zinc complexed with amino acids. Since the zinc amino acid complex likely mimics the absorption and retention of zinc bound to protein in food, the investigators further propose that zinc, bound to amino acids taken in the fasted state will be directed into the cellular compartments more efficiently than zinc associated with gluconate.
The investigators hypothesize that taking a zinc amino acid (Zn-AA) complex in a fasted state daily for two weeks has a greater effect on the Fatty Acid Desaturase 1 (FADS1) activity compared with zinc gluconate. Also, if the uptake of ionic zinc gluconate into cellular compartments is reduced in comparison to Zn-AA because the zinc gluconate is retained in the plasma, two weeks of a daily zinc gluconate will have a greater effect on fasting plasma zinc concentrations compared to a Zn- AA complex. conditions: Response of Fatty Acid Desaturation to Zinc Intake studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Participants will take the first zinc supplement for two weeks, followed by a two-week washout period, and then take the second zinc supplement for two weeks. The order of whether the first supplement is the zinc amino acid complex, or zinc gluconate, will be randomized. primaryPurpose: BASIC_SCIENCE masking: QUADRUPLE maskingDescription: The two zinc supplements will have the same appearance, and will be in coded bottles, such that the participant, care provider, investigator, and outcomes assessor may be kept unaware of the order of the supplements for each participant until the data analysis is complete. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: 30 mg Zn Amino Acid daily for 13 days name: 30 mg Zn Gluconate daily for 13 days measure: FADS1 activity index measure: Fasted plasma zinc concentration sex: MALE minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: University of California, Berkeley status: RECRUITING city: Berkeley state: California zip: 94720 country: United States name: Yasaman Massih, MPH role: CONTACT phone: 415-279-2171 email: ynmassih@berkeley.edu lat: 37.87159 lon: -122.27275 hasResults: False
nctId: NCT06348043 id: SU_PumpKIN id: 1UG3HL163311-01A1 type: NIH link: https://reporter.nih.gov/quickSearch/1UG3HL163311-01A1 briefTitle: Pumps for Kids, Infants and Neonates (PumpKIN): The Jarvik 2015 Pivotal Trial acronym: PumpKIN overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2028-12 date: 2029-12 date: 2024-04-04 date: 2024-04-04 name: Stanford University class: OTHER name: University of Texas name: Carelon Research name: National Heart, Lung, and Blood Institute (NHLBI) briefSummary: This is a 22-subject prospective, multicenter, single-arm clinical trial to evaluate the safety and effectiveness of the Jarvik 2015 left ventricular assist device (LVAD) as a bridge to heart transplant in children weighing 8 to 30 kilograms. Data generated from the study will be used to support FDA review and potential approval of the device under the Humanitarian Device Exemption (HDE) regulation, the FDA approval pathway for devices intended to treat rare and orphan diseases. conditions: Heart Failure With Reduced Ejection Fraction conditions: Pediatric HD, Stage IV conditions: LVAD studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 22 type: ESTIMATED name: Jarvik 2015 LVAD measure: Survival to heart transplant, recovery or 180 days of support in the absence of severe stroke. measure: Freedom from symptomatic stroke measure: Incidence rate of all protocol-defined SAE's through 180 days of support definitely or probably related to the device measure: Distribution of Pediatric Stroke Outcomes Measures measure: The KOSCHI score measure: Overall survival on Jarvik 2015 support to 180 days sex: ALL minimumAge: 6 Months maximumAge: 16 Years stdAges: CHILD hasResults: False
nctId: NCT06348030 id: 17401 briefTitle: Totally Robotic Versus Surgeon-Assisted Robotic Lung Resection For Early-Stage NSCLC overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-03 date: 2026-03 date: 2024-04-04 date: 2024-04-08 name: St. Joseph's Healthcare Hamilton class: OTHER briefSummary: Robotic-assisted thoracoscopic surgery (RTS) is safe and effective for patients with early-stage non-small cell lung cancer (NSCLC). During RTS, division, dissection, and sealing of lung tissue, bronchi, and blood vessels can be performed using handheld staplers with assistance from a bedside surgeon (Surgeon-Assisted), or totally robotically with robotic staplers and energy devices by the console surgeon (Totally Robotic). Totally Robotic lung resection enables the operating surgeon to perform the case independently, but its implication on costs and patient outcomes remains unknown. There also is, however, a lack of prospective research evaluating the costs of the two methods for dissection and vessel sealing in RTS. This RCT aims to evaluate the costs and perioperative patient outcomes of Totally Robotic lung resection using the Vessel Sealer Extend energy device (for vessels \<7mm) and the SureForm robotic stapler (Intervention) versus Surgeon-Assisted robotic lung resection using the Signia stapler (Control) during RTS for NSCLC using the da Vinci system. conditions: Lung Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 120 type: ESTIMATED name: Medtronic Signia Stapler name: Vessel Sealer Extend Energy Device and SureForm Stapler measure: Costs of Totally Robotic versus Surgeon-Assisted Robotic Lung Resection measure: Operating Room Time measure: Length of Stay in Hospital measure: Duration of Chest Tube measure: Intraoperative Complications and Adverse events (AEs) sex: ALL minimumAge: 18 Years maximumAge: 120 Years stdAges: ADULT stdAges: OLDER_ADULT facility: St. Joseph's Healthcare Hamilton city: Hamilton state: Ontario zip: L8N 4A6 country: Canada name: Yogita S Patel, BSc role: CONTACT phone: 905-522-1155 phoneExt: 35096 email: patelys@mcmaster.ca name: Waël C Hanna, MDCM, MBA, FRCSC role: PRINCIPAL_INVESTIGATOR lat: 43.25011 lon: -79.84963 hasResults: False
nctId: NCT06348017 id: Yozgat City Hospital briefTitle: Frequency of Neuropathic Pain in Patients With Plantar Fasciitis overallStatus: COMPLETED date: 2023-10-19 date: 2024-03-01 date: 2024-03-15 date: 2024-04-04 date: 2024-04-09 name: Yozgat City Hospital class: OTHER briefSummary: Study Design This prospective cross-sectional study was undertaken between November 2023 and March 2024. Written and verbal informed consent was obtained from all patients. The study protocol was approved by University Human Research Ethics Committee (AEŞH-EK 1-2023-612).
Patients While 106 patients who applied to the City Hospital Physical Medicine and Rehabilitation outpatient clinic with heel pain that had been present for at least six months, received foot radiography and were diagnosed with PF were included in the study as a patient group; 100 patients who did not have foot pain and had musculoskeletal pain for at least 6 months were included in the study as a control group, between November 2023 and March 2024. All the participants were aged 18 to 65 years. Patients with a history of diabetes, hypothyroidism and CKD, a history of malignancy, with vasculitis, neurological diseases that may cause neuropathic pain, lumbar discopathy, those with a previous history of fracture or surgery in the heel area, received injections or ESWT treatment due to heel pain in the last 3 months, rheumatic diseases that may affect pain such as rheumatoid arthritis, ankylosing spondylitis, fibromyalgia, and severe circulatory disorders on the side with pain, were excluded from the study. The study was commenced after obtaining the approval of the local ethics committee and informed consent of the participants.
All patients' personal information (age, gender, occupation, education information), general health information (smoking and alcohol use information, known chronic disease history, body mass index), severity of heel pain and when it started were recorded. While the Foot Function Index (FFI) scale, which evaluates the functionality of the foot, was applied to the patient group; the Visual Analog Scale (VAS), which evaluates pain intensity, the Pain-DETECT scale, which evaluates neuropathic pain, and the Central Sensitization Scale (CSI), which evaluates central sensitization, were applied to the patient and control groups. The details of the implementation of the instruments are as follows: conditions: Chronic Plantar Fasciitis conditions: Control Group studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 206 type: ACTUAL measure: Pain-DETECT measure: Foot Function Index measure: Central Sensitization Scale sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Yozgat City Hospital city: Yozgat zip: 66100 country: Turkey lat: 39.82 lon: 34.80444 hasResults: False
nctId: NCT06348004 id: 2024IIT-0125 briefTitle: The Association Between Albumin Administration and Short-term Rebleeding Risk in Cirrhosis Patients With Acute Variceal Hemorrhage and Stable Hemodynamics overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-01 date: 2024-04 date: 2024-04 date: 2024-04-04 date: 2024-04-04 name: Zhejiang University class: OTHER briefSummary: The impact of albumin administration in cirrhotics with acute variceal hemorrhage (AVH) is controversial. We aim to investigate the short-term rebleeding risk associated with albumin administration in a retrospective study of hospitalized cirrhotics with AVH with stable hemodynamics. This retrospective analysis includes clinical data of cirrhosis patients with acute variceal bleeding admitted to our hospital from January 2021 to October 2023. Propensity score matching will be performed to account for potential confounders associated with albumin use for outcome analysis. According to the outcome, patients will be divided into rebleeding group and non-rebleeding group. To investigate the impact of albumin infusion on the rebleeding risk in the propensity-matched cohort, patients will be divided into albumin user group and albumin non-user group. The primary outcome is the rebleeding risk within 30 days after discharge. conditions: Cirrhosis conditions: Acute Variceal Haemorrhage studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 500 type: ESTIMATED measure: The rebleeding risk within 30 days after discharge. sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The First Affiliated Hospital, Zhejiang University School of Medicine city: Hangzhou state: Zhejiang zip: 310000 country: China lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06347991 id: Pro00140155 briefTitle: Alberta Chiropractic SelfBack Study overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-31 date: 2025-12-31 date: 2024-04-04 date: 2024-04-04 name: University of Alberta class: OTHER name: Chiropractic Association of Alberta briefSummary: Recurrent and persistent low back pain (LBP) is a massive problem in Canada that causes a substantial pain, disability, cost, and even premature death.
As a result, the 50% of Canadians who do not have extended health benefits often seek care for LBP from their publicly funded physicians. Physicians, in turn, have little choice but to reach for what they have available, including opioids, x-rays and referrals to specialists. Not only are these interventions unhelpful for chronic LBP, they are often harmful, sometimes deadly, and disproportionately affect lower socio-economic status households.
The results of this study will help us understand the barriers and facilitators of distributing and using the app through Alberta Chiropractors. This information will be used to apply for funding for a larger study to understand the effectiveness of the app as an intervention for persistent and recurrent LBP. conditions: Chronic Low-back Pain studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 100 type: ESTIMATED name: SelfBack measure: The percentage of patients who utilize the SelfBack app measure: The percentage of clinicians who utilize the SelfBack app sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06347978 id: 24-41296 briefTitle: Personalized DBS for OCD Guided by Stereoencephalography Mapping overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2028-04 date: 2028-04 date: 2024-04-04 date: 2024-04-04 name: Andrew Moses Lee, MD, PhD class: OTHER briefSummary: This is a double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months. The study will be conducted in 3 stages: Stage 1 will consist of SEEG brain mapping and optimization of stimulation parameters. Stage 2 will consist of 4-lead DBS surgery with bilateral IPGs and further optimization of stimulation parameters. Stage 3 will be randomized, crossover treatment, followed by open label treatment. conditions: Obsessive-Compulsive Disorder conditions: OCD studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 10 type: ESTIMATED name: Deep Brain Stimulation measure: Primary Feasibility Endpoint #1 - Stimulation Target That Acutely Improves OCD Symptoms measure: Primary Feasibility Endpoint #2 - Identifying an electrophysiological biomarker of OCD measure: Primary Feasibility Endpoint #3 - Acute Symptomatic Improvement measure: Primary Feasibility Endpoint #4 - Completion of Stages 1 and 2 measure: Primary Safety Endpoint - Serious Adverse Events measure: Primary Efficacy Endpoint - Treatment Response measure: Secondary Efficacy Endpoint #1 - Improvement in YBOCS scores from Baseline measure: Secondary Efficacy Endpoint #2 - Improvement in OCD Symptoms from Baseline measure: Secondary Efficacy Endpoint #3 - Improvement in Depression Symptoms from Baseline sex: ALL minimumAge: 22 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of California, San Francisco city: San Francisco state: California zip: 94143 country: United States lat: 37.77493 lon: -122.41942 hasResults: False
nctId: NCT06347965 id: IIT20220541B-R1 briefTitle: Construction and Effect Evaluation of the Low Load Blood Flow Restriction Training Program for Lung Cancer Patients Complicated With Sarcopenia During Chemotherapy overallStatus: COMPLETED date: 2023-02-01 date: 2023-11-30 date: 2024-02-20 date: 2024-04-04 date: 2024-04-04 name: Xin Wang class: OTHER briefSummary: The goal of this clinical trial is to verify the effectiveness and safety of the low load blood flow restriction training program. The intervention effect, tolerance and compliance of low load blood flow restriction training and progressive resistance training on lung cancer patients complicated with sarcopenia during chemotherapy will be compared, in order to provide new ideas for improving or reversing sarcopenia.
3. Progressive resistance training group (PRE): The researchers will provide participants with progressive resistance training. conditions: Sarcopenia conditions: Lung Neoplasms studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 104 type: ACTUAL name: Low load blood flow restriction training name: Progressive resistance training group measure: Grip strength measure: Appendicular Skeletal Muscle Index (ASMI) measure: Step speed measure: Body mass index (BMI) measure: Quality of life for lung cancer patients measure: Exercise compliance measure: Exercise safety sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The First Affiliated Hospital, Zhejiang University School of Medicine city: HangZhou state: Zhejiang zip: 310020 country: China lat: 30.29365 lon: 120.16142 hasResults: False