hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06293235 id: 2024/2120 briefTitle: Towards Optimal Fertility, Fathering and Fatherhood studY acronym: TOFFFY overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2026-06 date: 2027-03 date: 2024-03-05 date: 2024-03-05 name: KK Women's and Children's Hospital class: OTHER_GOV briefSummary: This case-control study involving fertile and subfertile couples aims to identify male factors related to pregnancy likelihood, create a fertility index measure combining male and female factors to predict pregnancy likelihood, and examine how male factors relate to the semen physical and biological characteristics. conditions: Reproductive Issues conditions: Fertility Issues studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 960 type: ESTIMATED name: Lifestyle and metabolic indicators measure: Pregnancy rate measure: Fertility index measure: Oxidative stress measure: Semen volume measure: Sperm concentration measure: Sperm total motility measure: Sperm progressive motility measure: Total progressive motile sperm count measure: Single strand sperm DNA fragmentation measure: Double strand sperm DNA fragmentation measure: mRNA level measure: sncRNA level measure: DNA methylation measure: Sperm morphology sex: ALL minimumAge: 21 Years maximumAge: 49 Years stdAges: ADULT hasResults: False
nctId: NCT06293222 id: SCD Support briefTitle: Patient and Public Involvement and Engagement in Research With Children and Young People With Sickle Cell Disorder and Their Families overallStatus: ACTIVE_NOT_RECRUITING date: 2023-08-21 date: 2024-04-30 date: 2024-04-30 date: 2024-03-05 date: 2024-03-07 name: King's College London class: OTHER name: Sickle Cell Society briefSummary: Aim: To co-produce resources for inclusive and equitable Patient and Public Involvement and Engagement in research on life-limiting conditions, with children and young people with sickle cell disorder and their families.
Methods: Workshops with a) members of a patient advocacy organisation (Sickle Cell Society n=5) b): i) Children and young people (10-18 years) with sickle cell disorder (n=15) and ii) their siblings (10-18 years, n=10) and iii) their parents (n=15), c) Researchers form the Cicely Saunders Institute Outputs: Resources that enable children and young people with sickle cell disorder and their families to engage in research conditions: Sickle Cell Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED measure: Workshops with participants to develop resources that enable children and young people with sickle cell disorder and their families to engage in research sex: ALL minimumAge: 10 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: King's College London city: London zip: SE5 9RS country: United Kingdom lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06293209 id: Sunpasitthiprasong Hospital id: Sunpasitthiprasong Hospital type: OTHER domain: Sunpasitthiprasong Hospital briefTitle: Effect of Cool Spray and Cold Packs in Reducing Preoperative Edema and Pain in Ankle Fractures in Ubonratchathani acronym: 3-armRCT overallStatus: ACTIVE_NOT_RECRUITING date: 2023-08-01 date: 2024-02-28 date: 2024-05-28 date: 2024-03-05 date: 2024-03-05 name: Thai Traditional Medical Knowledge Fund class: OTHER_GOV briefSummary: The use of evaporative coolants in the management of acute musculoskeletal injury has received increasing attention recently. However, its efficacy compared with conventional cryotherapy in treating injured human subjects remains unclear.
The sample group comprises 30 patients admitted for treatment in the male orthopedic surgery department, female orthopedic surgery department, and accident orthopedic surgery department at Sunpasitthiprasong Hospital, Ubon Ratchathani from August 2023 to January 2024. . primaryPurpose: TREATMENT masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 90 type: ACTUAL name: 3M cold pack name: Perskindol cold spray name: Placebo measure: swelling measure: pain score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Orthopedics, Sunpasitthiprasong hospital, Ubonratchathani, Thailand. city: Multiple Locations state: Ubonrachathani zip: 34000 country: Thailand hasResults: False
nctId: NCT06293196 id: 20231107 briefTitle: Effects of Acupoint Massage Around Eyes on Ocular Biological Indexes overallStatus: RECRUITING date: 2023-09-01 date: 2024-03-31 date: 2025-06-30 date: 2024-03-05 date: 2024-03-05 name: Zhongnan Hospital class: OTHER briefSummary: This study aims to investigate whether the acupoint eye exercise could impact the biological parameters of the eye. conditions: Investigating the Effects of Periocular Acupressure on Ocular Biological Indicators studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 55 type: ESTIMATED name: acupressure measure: Changes in blood flow to the eye sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Zhongnan Hospital of Wuhan University status: RECRUITING city: Wuhan state: Hubei zip: 430000 country: China name: Min Ke, doctor of medicine role: CONTACT phone: 18672395959 email: Keminyk@163.com lat: 30.58333 lon: 114.26667 hasResults: False
nctId: NCT06293183 id: EGE-HEM-STO-01 briefTitle: The Effect of Artificial Intelligence Supported Mobile Learning on Nutrition/Hydration Control and Individual Management overallStatus: NOT_YET_RECRUITING date: 2024-04-04 date: 2024-09-30 date: 2024-12-30 date: 2024-03-05 date: 2024-03-05 name: Ege University class: OTHER briefSummary: The adherence to recommended nutrition and fluid restrictions is crucial for the success of hemodialysis treatment. However, approximately 80% of patients receiving HD treatment are non-compliant with fluid restriction, leading to various complications. Cardiovascular complications are among the most common complications associated with this issue. When reviewing national and international literature on the subject, it is observed that in order to improve treatment adherence in HD patients, written materials are often used in addition to individual or group education sessions, focusing mainly on assessing patients\' quality of life and self-efficacy. However, a mobile-supported learning method that enables patients to manage their nutrition and fluid control individually is not commonly utilized.
This research aims to investigate the impact of an artificial intelligence-supported mobile application developed for HD patients on the control of nutrition/fluid intake and individual management. conditions: Cronich Kidney Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 76 type: ESTIMATED name: Mobile app measure: Fluid intake compliance measure: Change of individual management sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06293170 id: 2024-DETECTIVENEUROLOGYUKD0001 briefTitle: Automated Screening for Clinically Ascertained Loss of Cerebral Functions acronym: DETECT-IVE overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-11-01 date: 2026-11-01 date: 2024-03-05 date: 2024-03-05 name: Technische Universität Dresden class: OTHER briefSummary: Rationale: The low organ donation rate in Germany is associated with the inadequate identification of patients at risk of developing irreversible loss of brain function (ILBF; i.e. brain death). An automated digital screening tool, DETECT (AutomateD ScrEening for Clinically AscerTainEd Loss of Cerebral FuncTions in Patients with Severe Brain Damage), has been developed to prospectively identify intensive care patients who are at risk of developing ILBF.
Intervention: DETECT periodically processes real-time data from the corresponding electronic medical record system to screen for a combination of coma, indicated by a Richmond Agitation Sedation Scale (RASS) score of - 4 or - 5 or Glasgow Coma Scale (GCS) score of 6-3, along with manually assessed absence of bilateral pupillary light reflexes. Both findings are considered early indicators of impending ILBF. In case of positive screening results, an automated notification will be sent via the hospital's email server to the corresponding transplant coordinators and intensivists. The email sent aims to prompt clinical assessment of the reported patient and, if necessary, initiate a guideline-based ILBF examination.
Secondary study endpoints: Secondary outcomes encompass the missed identification of potential ILBF cases (as retrospectively classified) and the rate of deceased organ donations. Upon completion of the study, a survey will be conducted to investigate the stakeholders' experiences with DETECT. conditions: Irreversible Loss of Brain Function (ILBF) studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: SCREENING masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 4800 type: ESTIMATED name: DETECT name: Conventional care measure: Number of patients with diagnosis of ILBF measure: Number of patients who undergo deceased organ donation measure: Number of patients in whom diagnosis of ILBF was missed sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden city: Dresden zip: 01307 country: Germany name: Kristian Barlinn, MD role: CONTACT phone: +49 (0)351 458 3565 email: kristian.barlinn@ukdd.de lat: 51.05089 lon: 13.73832 hasResults: False
nctId: NCT06293157 id: 2023/ABM/01/00013 briefTitle: Carbon Fiber Transpedicular Screws in Treatment of Spinal Metastatic Disease overallStatus: RECRUITING date: 2023-12-01 date: 2028-12-31 date: 2033-12-31 date: 2024-03-05 date: 2024-03-05 name: Copernicus Memorial Hospital class: OTHER name: Medical Research Agency, Poland briefSummary: Background: Spinal metastatic disease constitute a serious clinical problem in oncology. Bones are the third most common organ where metastases are located, and the spine is the place where they are most often located. Due to the complexity of the clinical problem, metastatic spine disease remains of interest to many medical specialties: neurosurgery, orthopedics, clinical oncology, radiotherapy and rehabilitation. With the development of modern diagnostic methods and wider access to them, the demand for neurosurgical treatment in this group of patients is growing. Surgical treatment is undertaken in cases of spinal cord compression, instability, spinal deformation or pain that is resistant to radiotherapy. The standard treatment in most cases is posterior instrumentation of the spine using titanium pedicle screws. Unfortunately, these systems cause numerous artifacts in diagnostic imaging, both in CT and MRI. These distortions make it difficult to plan radiotherapy and determine the optimal dose that would avoid healthy tissues. Moreover, artifacts could make difficult postoperative follow-ups aimed at assessing local recurrence. The solution to these problems is the use of radiolucent implants. There are systems based on carbon fibers embedded in PEEK which do not cause typical artifacts for titanium implants.
Study plan: The open, three-arm, prospective randomized study is planned to involve 226 patients with metastatic disease of the spine, with a known or undiagnosed primary site. Patients will be qualified for 2 types of interventions. The first one includes treatment with stereotactic radiotherapy (SBRT) in the first stage of treatment and early instrumentation of the spine with titanium implants. The second type of intervention includes patients qualified for surgical treatment using spine stabilization and postoperative SBRT. Patients within this arm will be randomized into two groups differing in the type of material the instrumentation is made of: carbon-PEEK or titanium. The study group will be patients stabilized with carbon implants, and the control group will be those who will have titanium implants.
Assumed effects: It is assumed that the treatment proposed in the project would extend progression free survival by several months or achieve local control in an additional 5% of patients. Moreover, by improving the quality of imaging, earlier diagnosis of local recurrences and implementation of appropriate locoregional treatment would be possible. conditions: Metastatic Spinal Cord Compression conditions: Metastasis Spine studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 226 type: ESTIMATED name: Transpedicular spinal stabilization - carbon fibers-based implants name: Transpedicular spinal stabilization - titanium implants name: Stereotactic body radiotherapy measure: The assessment of time to local recurrence after treatment with SBRT. measure: The assessment of frequency of local recurrence after treatment with SBRT. measure: DICE convergence factor evaluation between groups of patients. measure: The subjective difficulty of planning radiotherapy treatment. measure: The frequency of radiation complications assessed according to the National Cancer Institute Common Toxicity Criteria (NCI CTC). measure: Failure rate of stabilizing systems. measure: Pain assessment on the VAS scale between groups. measure: Frequency of postoperative infections. measure: Differences in dosimetric parameter Dmin PTV/CTV. measure: Differences in dosimetric parameter D95. measure: Differences in dosimetric parameter D98. measure: Differences in dosimetric parameter D100. measure: Differences in dosimetric parameter conformity index (CI) / homogeneity index (HI)). sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Copernicus Memorial Hospital in Lodz status: RECRUITING city: Łódź state: Łódzkie zip: 93-513 country: Poland name: Krystkiewicz role: CONTACT lat: 51.75 lon: 19.46667 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2022-05-16 uploadDate: 2024-02-25T03:37 filename: ICF_000.pdf size: 249036 hasResults: False
nctId: NCT06293144 id: yuewei20231129 briefTitle: the 95% Effective Dose of Ciprofol for Adjunctive Sedation Undergoing Knee Arthroplasty in Elderly People overallStatus: RECRUITING date: 2023-11-29 date: 2024-05 date: 2024-05 date: 2024-03-05 date: 2024-03-05 name: Second Hospital of Shanxi Medical University class: OTHER briefSummary: Regional anesthesia is a common clinical anesthesia method, and regional anesthesia-assisted sedation play a central role in promoting patient comfort and relieving anxiety. With increasing age, elderly people experience changes in pharmacokinetics and pharmacodynamics and increased drug sensitivity. Ciprofol has advantages in adverse events such as hypotension and respiratory depression. There are fewer studies on the recommended dosage of ciprofol-assisted sedation for intrathecal anesthesia in elderly patients. The aim of study is to identify the 95% effective dose of ciprofol-assisted sedation in elderly patients undergoing spinal anesthesia using a biased coin design up-and-down sequential method(BCD-UDM) conditions: Sedation conditions: ED95 conditions: Knee Arthroplasty studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SEQUENTIAL primaryPurpose: OTHER masking: NONE count: 70 type: ESTIMATED name: Ciprofol measure: Modified Alertness Sedation Score (MOAA/S) measure: Bispectral index (BIS) measure: systolic blood pressure （SBP） measure: diastolic blood pressure（DBP） measure: heart rate (HR) measure: pulse oxygen saturation（SpO2） measure: Occurrence of Sedation-related adverse events sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Second Hospital of Shanxi Medical University status: RECRUITING city: Taiyuan state: Shanxi zip: 030001 country: China name: Zheng Guo, M.B.,Ph.D. role: CONTACT phone: +863513365790 email: guozheng713@yahoo.com lat: 37.86944 lon: 112.56028 hasResults: False
nctId: NCT06293131 id: yuewei20230705 briefTitle: Median Effective Dose of Ciprofol-Assisted Sedation for Elderly Patients Undergoing Knee Arthroplasty overallStatus: COMPLETED date: 2023-05-29 date: 2023-09-28 date: 2023-09-28 date: 2024-03-05 date: 2024-03-05 name: Second Hospital of Shanxi Medical University class: OTHER briefSummary: Regional anesthesia is a common clinical anesthesia method, and regional anesthesia-assisted sedation play a central role in promoting patient comfort and relieving anxiety. With increasing age, elderly people experience changes in pharmacokinetics and pharmacodynamics and increased drug sensitivity. Ciprofol has advantages in adverse events such as hypotension and respiratory depression. There are fewer studies on the recommended dosage of ciprofol-assisted sedation for intrathecal anesthesia in elderly patients. The aim of study is to identify the median effective dose(ED50) of ciprofol-assisted sedation in elderly patients undergoing spinal anesthesia conditions: Sedation conditions: ED50 conditions: Knee Arthroplasty studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SEQUENTIAL primaryPurpose: OTHER masking: NONE count: 70 type: ACTUAL name: Ciprofol measure: Modified Alertness Sedation Score (MOAA/S) measure: Bispectral index (BIS) measure: systolic blood pressure （SBP） measure: diastolic blood pressure（DBP） measure: heart rate (HR) measure: pulse oxygen saturation（SpO2） measure: Occurrence of Sedation-related adverse events sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Second Hospital of Shanxi Medical University city: Taiyuan state: Shanxi zip: 030001 country: China lat: 37.86944 lon: 112.56028 hasResults: False
nctId: NCT06293118 id: 71055423.3.0000.0071 briefTitle: The Effects of Ischemic Conditioning in Individuals With Parkinson's Disease overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2028-01-15 date: 2024-03-05 date: 2024-03-05 name: Hospital Israelita Albert Einstein class: OTHER briefSummary: Ischemic conditioning (IC) is a promising therapy that can mimic the physiological effects of physical exercise. IC consists of using a cuff to measure blood pressure and calibrate 200 mmHg on the upper or lower limb. Thus, at alternating intervals of 5 minutes, ischemia or reperfusion occurs, depending on whether the cuff is inflated or deflated. IC induces changes in spinal cord excitability for the last reflex reactions of recruited motoneurons with improved balance control in healthy young people and improved learning in the elderly. The objective of the present study is to evaluate the chronic effect of IC on the motor function and cognitive performance of patients with Parkinson's disease. Furthermore, the investigators will evaluate secondary outcomes such as mobility, quality of life, and immunological responses. conditions: Parkinson Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 1. Ischemic conditioning group
2. control group (Sham) primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Patients were unaware of the allocation. whoMasked: PARTICIPANT count: 34 type: ESTIMATED name: Ischemic conditioning group name: Sham group measure: Motor function measure: Cognitive performance measure: PDQ-39 measure: Timed up and go (TUG) measure: Assessment of cellular and soluble immune response measure: Quantifications of systemic soluble mediators measure: PBMC acquisition and flow cytometry sex: ALL minimumAge: 40 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06293105 id: MR/T040688/1 briefTitle: Social Responses to Stigma overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-01-31 date: 2025-01-31 date: 2024-03-05 date: 2024-03-05 name: King's College London class: OTHER name: Groundswell name: Lambeth Service Users Council name: Museum of Homelessness name: Inclusive Insight briefSummary: The Social Responses to Stigma study will explore experiences of stigma and discrimination amongst people who are homeless in south London, and then seek to understand how this stigma is created, mediated or mitigated within health, social, housing and legal care and support systems and social contexts.
The results of the study will inform the design of a novel intervention strategy to address the social dimensions of stigma. Subject to additional funding applications, the intervention strategy will be piloted and evaluated from 2025 onwards. The study results will be disseminated through scientific publications, public reports and a range of public and policy engagement activities. conditions: Stigma, Social conditions: Drug Use studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: OTHER count: 200 type: ESTIMATED name: Qualitative interview, participant observation measure: Experiences of stigma and discrimination sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: to Be Determined city: London country: United Kingdom lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06293092 id: P.T.REC/012/004008 briefTitle: Effect of Intradialytic Exercises in Chronic Kidney Disease Patients overallStatus: COMPLETED date: 2022-04-30 date: 2023-10-30 date: 2024-01-30 date: 2024-03-05 date: 2024-03-05 name: Cairo University class: OTHER briefSummary: the purpose of this study is to compare between intradialytic aerobic versus resistive exercises on immunity response in patients with chronic kidney disease. conditions: Chronic Kidney Disease stage3 studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: control group receive medical treatment only ,first study group receive medical treatment and intradialytic aerobic exercise , second study group receive medical treatment and intradialytic resistive exercise primaryPurpose: TREATMENT masking: NONE count: 60 type: ACTUAL name: leg pedaling cycling device name: sand bags name: hemodialysis sessions measure: Concentration of immunoglobulin g measure: Total leukocyte count measure: lymphocyte count measure: neutrophil count measure: Concentration of HbA1c measure: hemoglobin concentration measure: thrombocytes count measure: diastolic blood pressure measure: Systolic blood pressure measure: six minute walk test measure: (KDQOL-SFTM) questionnaire sex: MALE minimumAge: 50 Years maximumAge: 60 Years stdAges: ADULT facility: Fayoum hospital city: Fayoum country: Egypt lat: 29.30995 lon: 30.8418 hasResults: False