The main task is to evaluate and compare the effectiveness of RPH-075 and Keytruda® drugs when used in patients with unresectable or metastatic skin melanoma as a 1 or 2 line therapy in monotherapy regimen, according to the objective response rate (ORR) parameter for up to 24 weeks of therapy. conditions: Skin Melanoma studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 266 type: ACTUAL name: RPH-075 name: Keytruda® measure: The objective response rate (ORR) measure: The disease control rate (DCR) measure: The time to response (TTR) measure: The Duration of response (DOR) measure: The Progression-free survival (PFS) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Federal State Budgetary Institution "National Medical Research Center of Radiology" of the Ministry of Health of the Russian Federation city: Obninsk state: Kaluga Region zip: 249036 country: Russian Federation lat: 55.09681 lon: 36.61006 facility: State Budgetary Healthcare Institution "Clinical Oncological Dispensary No. 1" of the Ministry of Health of the Krasnodar Territory city: Krasnodar state: Krasnodar Territory zip: 350040 country: Russian Federation lat: 45.04484 lon: 38.97603 facility: Regional Budgetary Healthcare Institution "Kursk Oncological Research and Clinical Center named after G.E. Ostroverkhov" city: Kislino state: Kursk Region zip: 305524 country: Russian Federation facility: State Budgetary Healthcare Institution of the city of Moscow "Moscow City Oncological Hospital No. 62 of the Department of Health of the City of Moscow" city: Istra state: Moscow Region zip: 143515 country: Russian Federation lat: 55.91997 lon: 36.86867 facility: The State budgetary healthcare Institution of the Stavropol Territory "Pyatigorsk Interdistrict Oncological Dispensary" city: Pyatigorsk state: Stavropol Territory zip: 357502 country: Russian Federation lat: 44.04861 lon: 43.05944 facility: The State Autonomous Healthcare Institution of the Sverdlovsk region "Sverdlovsk Regional Oncological Dispensary" city: Ekaterinburg state: Sverdlovsk Region zip: 620036 country: Russian Federation lat: 56.8519 lon: 60.6122 facility: State Autonomous Healthcare Institution Republican Clinical Oncological Dispensary of the Ministry of Health of the Republic of Bashkortostan city: Ufa state: The Republic Of Bashkortostan zip: 450054 country: Russian Federation lat: 54.74306 lon: 55.96779 facility: State Autonomous Healthcare Institution "Republican Clinical Oncological Dispensary of the Ministry of Health of the Republic of Tatarstan named after Professor M.Z.Segal" city: Kazan state: The Republic Of Tatarstan zip: 420029 country: Russian Federation lat: 55.78874 lon: 49.12214 facility: Budgetary Healthcare Institution of the Udmurt Republic "Sergey Grigoryevich Primushko Republican Clinical Oncological Dispensary of the Ministry of Health of the Udmurt Republic" city: Izhevsk state: Udmurt Republic zip: 426009 country: Russian Federation lat: 56.84976 lon: 53.20448 facility: State Budgetary Healthcare Institution of the Arkhangelsk region "Arkhangelsk Clinical Oncological Dispensary" city: Arkhangelsk zip: 163045 country: Russian Federation lat: 64.5401 lon: 40.5433 facility: State Budgetary Healthcare Institution "Regional Oncological Dispensary" city: Irkutsk zip: 664035 country: Russian Federation lat: 52.29778 lon: 104.29639 facility: Regional budgetary healthcare institution "Ivanovo Regional Oncological Dispensary" city: Ivanovo zip: 153040 country: Russian Federation lat: 56.99719 lon: 40.97139 facility: Kaluga Region State Budgetary Healthcare Institution "Kaluga Regional Clinical Oncological Dispensary" city: Kaluga zip: 248007 country: Russian Federation lat: 54.5293 lon: 36.27542 facility: State Budgetary healthcare Institution "Kuzbass Clinical Oncological Dispensary named after M.S. Rappoport" city: Kemerovo zip: 650036 country: Russian Federation lat: 55.33333 lon: 86.08333 facility: Regional State Budgetary Healthcare Institution "Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I. Kryzhanovsky" city: Krasnoyarsk zip: 660133 country: Russian Federation lat: 56.01839 lon: 92.86717 facility: State Budgetary Institution of healthcare of the city of Moscow "Moscow Multidisciplinary Clinical Center "Kommunarka" of the Department of Healthcare of the City of Moscow" city: Moscow zip: 108814 country: Russian Federation lat: 55.75222 lon: 37.61556 facility: Federal State Budgetary Institution "N.N. Blokhin National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation city: Moscow zip: 115478 country: Russian Federation lat: 55.75222 lon: 37.61556 facility: State Budgetary Healthcare Institution of the city of Moscow "City Clinical Oncological Hospital No. 1 of the Department of Health of the City of Moscow" city: Moscow zip: 117152 country: Russian Federation lat: 55.75222 lon: 37.61556 facility: Federal State Autonomous Education Insitution of High Education the First Moscow State Medical University named after I.M. Sechenov of Ministry of Healthcare of Russian Federation (Sechenov University) city: Moscow zip: 119991 country: Russian Federation lat: 55.75222 lon: 37.61556 facility: Branch Office of "Hadassah Medical Ltd" city: Moscow zip: 121205 country: Russian Federation lat: 55.75222 lon: 37.61556 facility: "Moscow Center for Rehabilitation Treatment" LLC city: Moscow zip: 121552 country: Russian Federation lat: 55.75222 lon: 37.61556 facility: Medsi Group of Companies JSC city: Moscow zip: 123056 country: Russian Federation lat: 55.75222 lon: 37.61556 facility: "Research lab" LLC city: Moscow zip: 127521 country: Russian Federation lat: 55.75222 lon: 37.61556 facility: State Budgetary Healthcare Institution of the Nizhny Novgorod region "Nizhny Novgorod Regional Clinical Oncological Dispensary" city: Nizhny Novgorod zip: 603126 country: Russian Federation lat: 56.32867 lon: 44.00205 facility: State Budgetary Healthcare Institution of the Novosibirsk region "Novosibirsk Regional Clinical Oncological Dispensary" city: Novosibirsk zip: 630108 country: Russian Federation lat: 55.0415 lon: 82.9346 facility: Budgetary healthcare institution of the Omsk region "Clinical Oncological Dispensary" city: Omsk zip: 644013 country: Russian Federation lat: 54.99244 lon: 73.36859 facility: State Budgetary Healthcare Institution of the Perm Territory "Perm Regional Oncological Dispensary" city: Perm zip: 614066 country: Russian Federation lat: 58.01046 lon: 56.25017 facility: State Budgetary Healthcare Institution Leningrad Regional Clinical Hospital city: Saint Petersburg zip: 188300 country: Russian Federation lat: 59.93863 lon: 30.31413 facility: Private healthcare institution "Clinical Hospital "Russian Railways-Medicine" of the city of St. Petersburg" city: Saint Petersburg zip: 195271 country: Russian Federation lat: 59.93863 lon: 30.31413 facility: "Euro Cityclinic" LLC city: Saint Petersburg zip: 197022 country: Russian Federation lat: 59.93863 lon: 30.31413 facility: St. Petersburg State Budgetary Healthcare Institution "City Clinical Oncological Dispensary" city: Saint Petersburg zip: 197022 country: Russian Federation lat: 59.93863 lon: 30.31413 facility: State Budgetary Healthcare Institution "Samara Regional Clinical Oncological Dispensary" city: Samara zip: 443031 country: Russian Federation lat: 53.20007 lon: 50.15 facility: State Healthcare Institution "Regional Clinical Oncological Dispensary" city: Saratov zip: 410053 country: Russian Federation lat: 51.54056 lon: 46.00861 facility: Regional State Budgetary Healthcare Institution "Smolensk Regional Oncological Clinical Dispensary" city: Smolensk zip: 214000 country: Russian Federation lat: 54.7818 lon: 32.0401 facility: Siberian State Medical University of the Ministry of Healthcare of Russian Federation city: Tomsk zip: 634050 country: Russian Federation lat: 56.49771 lon: 84.97437 facility: The State Autonomous healthcare Institution of the Tyumen region "Multidisciplinary clinical Medical Center "Medical City" city: Tyumen zip: 625041 country: Russian Federation lat: 57.15222 lon: 65.52722 hasResults: False