nctId: NCT06299722 id: N-20230055 briefTitle: Strength Training Exercises to Minimise Late Effects of Childhood Leukaemia or Lymphoma Among Adolescents acronym: STEEL overallStatus: RECRUITING date: 2024-03-15 date: 2025-07 date: 2025-07 date: 2024-03-08 date: 2024-03-19 name: Aalborg University class: OTHER briefSummary: We aim to include 60 children and adolescents aged 10 to 19 years who have undergone successful treatment for leukemia or lymphoma. Based on randomization, they will either 1) commence 16 weeks of training with STEEL or 2) commence 16 weeks of circuit training. STEEL training involves exercises for major muscle groups using free weights, body weight, or tailored machines. Circuit training is structured similarly to previous training for the target group and includes exercises using body weight, exercise balls, and rings. The training takes place in local centers either with friends or with other participants in the project. Before starting participation in the project, the child/adolescent and their parents or guardians will receive information about late effects, diet, sleep, and exercise, providing guidance and support regarding the project elements. The effects of the two training modalities will be evaluated based on self-reported quality of life, muscle strength, muscle mass, bone mineral content, fitness, and markers of metabolic syndrome (BMI, waist circumference, blood pressure, and blood analysis). conditions: Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: STEEL name: Circuit training measure: Isometric strength measure: Health-related quality of life measure: Step counts measure: Caloric expenditure measure: Maximal dynamic strength measure: Bone mineral density of the lumbar spine and body composition measure: Grip strength and rate of force development measure: Muscular strength, endurance, and rate of force development measure: Cardiorespiratory fitness and endurance measure: Exercise compliance and fidelity measure: Adverse events measure: Movement-evoked pain measure: Satisfaction with the intervention measure: Blood glucose measure: Glycated hemoglobin (Hba1c) measure: Insulin measure: Proinsulin c-peptide measure: Total cholesterol measure: High-density lipoprotein cholesterol measure: Low-density lipoprotein cholesterol measure: Very low-density lipoprotein cholesterol measure: Triglycerides measure: Glucagon measure: Homeostatic Model assessment for Insulin resistance score measure: Body Mass Index (BMI) measure: Lean body mass measure: Fat mass measure: Android/gynoid fat distribution measure: Abdominal circumference measure: Self-reported Tanner staging measure: Blood pressure sex: ALL minimumAge: 10 Years maximumAge: 19 Years stdAges: CHILD stdAges: ADULT facility: Rigshospitalet status: RECRUITING city: Copenhagen country: Denmark name: Martin K Fridh role: CONTACT email: martin.kaj.fridh@regionh.dk lat: 55.67594 lon: 12.56553 facility: Aalborg University status: RECRUITING city: Gistrup zip: 9260 country: Denmark name: Henrik Riel role: CONTACT email: hriel@dcm.aau.dk lat: 56.9943 lon: 9.99085 facility: Odense University Hospital status: RECRUITING city: Odense country: Denmark name: Mathias Rathe role: CONTACT email: mathias.rathe@rsyd.dk lat: 55.39594 lon: 10.38831 facility: Århus University Hospital status: RECRUITING city: Århus country: Denmark name: Clara Vad role: CONTACT email: claravad@live.dk lat: 56.15674 lon: 10.21076 hasResults: False