nctId: NCT06342440 id: 23228/AACRC briefTitle: Early Detection of Advanced Adenomas and Colorectal Cancer acronym: AACRC overallStatus: RECRUITING date: 2020-03-15 date: 2025-12-15 date: 2025-12-15 date: 2024-04-02 date: 2024-04-02 name: City of Hope Medical Center class: OTHER briefSummary: This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses. conditions: Colorectal Cancer conditions: Colorectal Neoplasms conditions: Colorectal Polyp conditions: Colorectal Adenocarcinoma conditions: Colorectal Disorders conditions: Colorectal Dysplasia conditions: Colorectal Cancer Stage I conditions: Colorectal Cancer Stage II conditions: Colorectal Cancer Stage III conditions: Colorectal Cancer Stage IV conditions: Colorectal Neoplasms Malignant conditions: Colorectal Serrated Adenocarcinoma conditions: Colorectal Adenoma With Severe Dysplasia conditions: Colorectal Adenoma With Mild Dysplasia conditions: Colorectal Adenoma With Moderate Dysplasia conditions: Colorectal Adenoma and Carcinoma 1 conditions: Colorectal Adenomatous Polyp conditions: Colorectal Adenocarcinoma Metastatic in the Liver studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 2000 type: ESTIMATED name: DENEB measure: Sensitivity measure: Specificity measure: Proportion of correct predictions (true positives and true negatives) among the total number of cases (i.e., accuracy) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: City of Hope Medical Center status: RECRUITING city: Monrovia state: California zip: 91016 country: United States name: Ajay Goel, PhD role: CONTACT phone: 626-218-3452 email: AJGOEL@COH.ORG name: Ajay Goel, PhD role: PRINCIPAL_INVESTIGATOR name: Caiming Xu role: SUB_INVESTIGATOR name: Alessandro Mannucci role: SUB_INVESTIGATOR name: James Lin role: SUB_INVESTIGATOR name: Gregory Idos role: SUB_INVESTIGATOR name: Trilokesh Kadambi role: SUB_INVESTIGATOR lat: 34.14806 lon: -117.99895 facility: University of California San Diego status: RECRUITING city: San Diego state: California zip: 92093 country: United States name: C Richard Boland, MD, PhD role: CONTACT name: C Richard Boland, MD, PhD role: SUB_INVESTIGATOR lat: 32.71533 lon: -117.15726 facility: The First Affiliated Hospital of Dalian Medical University status: RECRUITING city: Dalian country: China name: Jing Zhang role: CONTACT name: Jing Zhang role: SUB_INVESTIGATOR name: Caiming Xu role: SUB_INVESTIGATOR lat: 38.91222 lon: 121.60222 facility: IRCCS San Raffaele status: RECRUITING city: Milan country: Italy name: Giulia Martina Cavestro, MD, PhD role: CONTACT email: cavestro.giuliamartina@hsr.it name: Giulia Martina Cavestro role: SUB_INVESTIGATOR name: Alessandro Mannucci role: SUB_INVESTIGATOR lat: 45.46427 lon: 9.18951 facility: Mie University status: RECRUITING city: Mie country: Japan name: Yuji Toiyama role: CONTACT name: Yuji Toiyama role: SUB_INVESTIGATOR name: Yoshinaga Okugawa role: SUB_INVESTIGATOR name: Tadanobu Shimura role: SUB_INVESTIGATOR facility: Barcelona University status: RECRUITING city: Barcelona country: Spain name: Francesc Balaguer, MD, PhD role: CONTACT email: fprunes@clinic.cat name: Francesc Balaguer role: SUB_INVESTIGATOR name: Miguel Pera role: SUB_INVESTIGATOR name: Lorena Moreno role: SUB_INVESTIGATOR name: Luis Bujanda role: SUB_INVESTIGATOR lat: 41.38879 lon: 2.15899 hasResults: False