hackint0sh/New-Dataset huggingface dataset:
* the in vitro therapeutic response of hepatocellular carcinoma organoids conditions: Hepatocellular Carcinoma studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 10 type: ESTIMATED name: Liver biopsy measure: Success rate of hepatocellular carcinoma organoids integrated with host gut microbiota and peripheral blood mononuclear cells measure: Analysis of hepatocellular carcinoma organoid transcriptome distribution within a reference set from The Cancer Genome Atlas measure: Evaluation of the concordance of somatic genetic mutations between the organoid and the original tumor measure: Correlation between gut microbiota community profiling and growth rate of hepatocellular carcinoma organoids measure: Treatment response evaluation in vitro sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione Policlinico Agostino Gemelli IRCCS status: RECRUITING city: Roma zip: 00168 country: Italy name: Francesca Ponziani, MD role: CONTACT phone: +390630156018 email: comitato.etico@policlinicogemelli.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06355687 id: FMASU MD304/2023 briefTitle: Melatonin in Obese Patients in Laparoscopic Cholecystectomy overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-04-09 date: 2024-04-09 name: Ain Shams University class: OTHER briefSummary: Opioid free anesthesia (OFA) means a technique in which no intraoperative opioid is administered through any route. Perioperative pain management in an obese patient is challenging. The incidence of respiratory depression is higher in obese patients and is exaggerated with opioids, so the investigators are searching for a drug that has analgesic effect without any effect on respiratory function. In this study, the investigators will add melatonin to OFA in obese patients undergoing laparoscopic cholecystectomy. conditions: Anesthesia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 60 type: ESTIMATED name: Melatonin name: Vitamin Supplement measure: Postoperative Pain. measure: Postoperative Pain. measure: Analgesics usage. measure: Postoperative nausea and vomiting. measure: Recovery time. measure: Number of participants with hemodynamic instability. measure: Number of participants with hemodynamic instability. sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT hasResults: False
nctId: NCT06355674 id: HRÜ/23.21.12 briefTitle: Adolescent Mother and Breastfeeding Education overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2024-09-15 date: 2024-10-15 date: 2024-04-09 date: 2024-04-09 name: Adiyaman University class: OTHER briefSummary: In low-income and developing countries, 30% of adolescents marry before the age of 18, and 14% marry before the age of 15. Additionally, adolescents between the ages of 15 and 19 are often coerced into marriage or sexual relationships with partners older than themselves. 10% of adolescents under the age of 15 in the world are forced to have sexual intercourse and as a result, unwanted teenage pregnancies occur. In high-income countries like Latin America, there is a high prevalence of adolescent non-marital pregnancies. When considering the fertility, health, and social outcomes of adolescence, it emerges as a significant issue. Adolescent motherhood carries numerous adverse effects from both demographic and social perspectives.
In pregnancies occurring during adolescence, both maternal and infant mortality rates are two to three times higher compared to pregnancies at later ages. Many infant and child deaths occur due to preventable causes. Breastfeeding is a significant factor in reducing infant and child mortality. Since infants born to adolescent mothers are at higher risk of death and illness, breastfeeding these infants becomes even more important. However, one of the significant challenges adolescent mothers face during the postpartum period is initiating and maintaining lactation. Research has shown that maternal age plays a significant role in initiating and sustaining breastfeeding, with a strong positive correlation between maternal age and duration of breastfeeding. This study was designed as a randomized controlled trial to examine the effect of breastfeeding education provided to adolescent mothers on maternal breastfeeding self-efficacy, mother-infant attachment, and infant anthropometric measurements. conditions: Adolescent Mother studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 80 type: ESTIMATED name: Breastfeeding education provided with Lactation Simulation Model measure: Postnatal Breastfeeding Self-Efficacy Scale-Short Form measure: Maternal-Infant Attachment Scale sex: FEMALE minimumAge: 12 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06355661 id: HP/231102/PA/URTI briefTitle: A Study for Assessing the Efficacy and Safety ParActin® in Individuals With Upper Respiratory Tract Infections overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-05-15 date: 2024-06-01 date: 2024-04-09 date: 2024-04-09 name: Vedic Lifesciences Pvt. Ltd. class: INDUSTRY briefSummary: The present study is a randomized, double-blind, placebo-controlled, comparative study. 176 individuals will be screened, and considering a screening failure rate of 15 percent approximately 150 will be randomized in a ratio of 1:1 to receive either IP or placebo and will be assigned a unique randomization code. Each group will have at least 60 completed participants after accounting for a dropout/withdrawal rate of 20percent. The intervention duration for all the study participants is 7 days conditions: Upper Respiratory Tract Infections studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A Double-blind, Randomized, Placebo-Controlled primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: ParActin®: 300 mg + MCC: 100 mg (± 10%) per Capsule name: MCC: 400 mg (± 10%) per Capsule measure: To evaluate the effect of investigational products on participant's severity of common cold like symptoms measure: To evaluate the effect of investigational products on Time (in days) taken to resolution of common cold like symptoms measure: To evaluate the effect of investigational products on Percentage of participants with unresolved common cold symptoms measure: To evaluate the effect of investigational products on Percentage of population with minimal important difference of ≥ 10.3 as per change in Wisconsin Upper Respiratory Symptom Survey-21 total score. (daily score will be analysed in study) measure: To evaluate the effect of investigational products on Number of days taken to be afebrile (temp < 100 oF/< 37.7 ºC) in the population with fever (temp ≥100oF or ≥37.7 ºC ) at baseline- as assessed by 10-point visual analogue scale. measure: To evaluate the effect of investigational products on Percentage population with fever during the study. measure: To evaluate the effect of investigational products on Quality of life as assessed by Wisconsin Upper Respiratory Symptom Survey Quality of Life sex: ALL minimumAge: 16 Years maximumAge: 50 Years stdAges: CHILD stdAges: ADULT facility: Biswas health care & Diagnostic Centre city: Nainital state: Uttaranchal country: India name: Dr Bijay Biswas, MBBS,MD role: CONTACT phone: 919760010003 email: biswasclinic058@gmail.com lat: 29.39743 lon: 79.44686 hasResults: False
nctId: NCT06355648 id: IRAS 337181 briefTitle: Advanced Clinical Practitioners in the ED overallStatus: NOT_YET_RECRUITING date: 2024-05-03 date: 2024-10-01 date: 2025-03-01 date: 2024-04-09 date: 2024-04-09 name: King's College London class: OTHER briefSummary: No patient data is involved in the study. This study is designed to understand better how Emergency Care Advanced Clinical Practitioners (EC-ACPs) work in emergency departments (EDs). The main research question is:
In the UK, a health care role has been developed called Advanced Clinical Practitioners (ACPs). ACPs work in various clinical settings, but this study focuses on those in Emergency Care. While non-medical practitioners have worked in Emergency Departments (EDs) for over 20 years, the ACP role is relatively new. Most ACPs in ED are from a nursing or paramedical background, but they can also be from other allied health professions like physiotherapy. After the base qualification, ACPs undertake a three-year master\'s degree with clinical portfolios. Once qualified, the goal is to create clinicians who work alongside doctors, seeing, treating, and discharging patients. Unlike previous practitioner roles, EC-ACPs treat the whole spectrum of ED patients, from minor injuries and illnesses to the sickest patients needing the highest level of care.
Previous research on advanced roles in ED has focused on direct clinical comparisons between doctors and practitioners. Researchers have investigated which professional (doctors vs. nurse practitioners) triages patients quickest or who is more accurate at interpreting X-rays. There are several problems with these approaches. The first is that they can create a professional rivalry. The second problem is that these approaches oversimplify what is a more complex system of care. conditions: Healthy Volunteers studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 30 type: ESTIMATED measure: Narrative data measure: Narrative data sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06355635 id: JohannesGUVA briefTitle: Application and Monitoring of Vasoactive and Inotrope Drugs acronym: Vasin overallStatus: RECRUITING date: 2024-04-04 date: 2024-06-01 date: 2024-11-01 date: 2024-04-09 date: 2024-04-09 name: Johannes Gutenberg University Mainz class: OTHER briefSummary: The investigators aimed to establish current practice of application and monitoring of vasoactive and inotrope Drugs in non-cardiac surgery patients. conditions: Hemodynamic Instability studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: Choice and Monitoring measure: current practice of correct application and monitoring of vasoactive and inotrope Drugs sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Anaesthesiology; status: RECRUITING city: Mainz state: Rhineland-Palatinate zip: D55131 country: Germany name: Marc Kriege, MD role: CONTACT phone: 00496131170 email: MaKriege@uni-mainz.de lat: 49.98419 lon: 8.2791 hasResults: False
nctId: NCT06355622 id: 3717 briefTitle: Prevalence and Characterization of Pain in RASopathies acronym: 3717 overallStatus: RECRUITING date: 2021-01-27 date: 2024-01-30 date: 2024-06-30 date: 2024-04-09 date: 2024-04-09 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: RASopathies are a group of syndromes caused by variants in genes belonging to the RAS/MAPK pathway. Pain is a neglected topic in RASopathies but it is frequently complained by affected individuals. conditions: RASopathy conditions: Costello Syndrome conditions: Cardio-Facio-Cutaneous Syndrome conditions: Noonan Syndrome studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 150 type: ESTIMATED name: Characterization of pain measure: Prevalence of pain in verbal patients with RASopathies measure: Prevalence of Pain in no-communitating patients with RASopathies measure: Characterization of pain in RASopathies sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Woman and Child Health and Public Health, Fondazione Policlinico A. Gemelli, IRCCS status: RECRUITING city: Roma zip: 00168 country: Italy name: Chiara Leoni, MD, PhD role: CONTACT phone: 0039063381344 email: chiara.leoni@policlinicogemelli.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06355609 id: DZ2023EI004-RW briefTitle: Sunvozertinib Plus Anlotinib as 1L Treatment in EGFR Mutant Advanced NSCLC-RW acronym: WUKONG-32-RW overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2025-12-30 date: 2027-12-30 date: 2024-04-09 date: 2024-04-09 name: Hunan Province Tumor Hospital class: OTHER briefSummary: This is a phase II, open-label, single-arm, single-center clinical study to evaluate the preliminary efficacy of sunvozertinib in combination with anlotinib in patients with EGFR-sensitive mutations and co-mutations in locally advanced or metastatic treatment-naive non-small cell lung cancer. conditions: Non-small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: sunvozertinib in combination with Anlotinib measure: Progression-free survival (PFS) measure: Objective Response Rate (ORR) measure: Overall survival (OS) measure: Duration of Response (DoR) measure: Adverse events (AEs) according to CTCAE 5.0 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hunan Cancer Hospital city: Changsha state: Hunan zip: 410013 country: China lat: 28.19874 lon: 112.97087 hasResults: False
nctId: NCT06355596 id: 20IC6361 briefTitle: Development and Validation of a Virtual Teaching Method for Minimally Invasive Surgery Skills overallStatus: COMPLETED date: 2022-03-11 date: 2022-04-08 date: 2022-04-08 date: 2024-04-09 date: 2024-04-09 name: Imperial College London class: OTHER briefSummary: The goal of this observational study is to develop and evaluate a virtual teaching method for minimally invasive surgery (MIS) skills among novice learners, using widely available technology and incorporating objective assessments of proficiency. The main questions it aims to answer are:
Have their performance and cognitive workload parameters (SURG-TLX score, heart rate, and pupil metrics) evaluated during the tasks. conditions: Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescription: Participants are randomly allocated to either face-to-face or virtual teaching groups primaryPurpose: OTHER masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 20 type: ACTUAL name: Virtual teaching measure: McGill Inanimate System for Training and Evaluation of Laparoscopic Skills (MISTELS) peg transfer task score measure: European Academy laparoscopic 'Suturing Training and Testing' (SUTT) assessment score measure: SURG-TLX score measure: Heart rate measure: Pupil metrics sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: St Mary's Hospital city: London zip: W2 1NY country: United Kingdom lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06355583 id: C/42/2022 id: 2022-003617-10 type: EUDRACT_NUMBER briefTitle: Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial acronym: MAST overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-02-01 date: 2027-05-01 date: 2024-04-09 date: 2024-04-09 name: Imperial College London class: OTHER briefSummary: The goal of this clinical trial is to test the ability to restore gut microbiota to healthier levels in patients with blood cancers scheduled to have stem cell transplant.
nctId: NCT06355570 id: 331314 id: RFPR2324_29 type: OTHER_GRANT domain: Imperial Health Charity id: 24/YH/0011 type: OTHER domain: UK Health Research Authority (Research Ethics Committee) briefTitle: Delirium After Cardiac Surgery in Intensive Care Units acronym: DaCsi-ICU overallStatus: RECRUITING date: 2024-03-20 date: 2024-12-31 date: 2025-03-20 date: 2024-04-09 date: 2024-04-11 name: Imperial College Healthcare NHS Trust class: OTHER briefSummary: STUDY SUMMARY
DURATION 12 months at Hammersmith Hospital, ICHT conditions: Intensive Care Unit Delirium conditions: Cardiac Surgery conditions: Post Operative Delirium studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: 12-patient participants will be submitted to the study intervention. primaryPurpose: BASIC_SCIENCE masking: NONE count: 30 type: ESTIMATED name: Personal Pictures name: Family Videos name: Family Videos - Intervention as required measure: Feasibility of implementing the study intervention measure: Practicalities of introducing the study intervention measure: Acceptability of implementing the study intervention measure: Short-term delirium outcomes post-ICU discharge sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Imperial College Healthcare NHS Trust status: RECRUITING city: London zip: W12 0HS country: United Kingdom name: Maria Reguenga, BSN role: CONTACT phone: +442033131703 email: maria.reguenga@nhs.net name: Sanooj Soni, PhD role: CONTACT phone: 07714329708 email: sanooj.soni@nhs.net lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06355557 id: DSRB 2023/00640 briefTitle: Human vs Machine: a RCT Comparing Traditional In-person Instruction, AI Versus VR for Learning Basic CCE overallStatus: RECRUITING date: 2024-04-04 date: 2024-12-31 date: 2025-01 date: 2024-04-09 date: 2024-04-09 name: Tan Tock Seng Hospital class: OTHER briefSummary: The aim of the study is to investigate if hands-on training for basic CCE with virtual reality simulators or guided by artificial intelligence is non-inferior to training by an experienced instructor. conditions: Ultrasound studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 3-arm prospective randomised controlled trial. primaryPurpose: OTHER masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 66 type: ESTIMATED name: AI enabled ultrasound system for self-directed learning name: Simulator for self-directed learning name: traditional with human instructors measure: Improvement in image acquisition and structure identification at the end of 3 months. sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tan Tock Seng Hospital status: RECRUITING city: Singapore zip: 319581 country: Singapore name: Yie H Lau role: CONTACT phone: 6563577771 email: yie_hui_lau@ttsh.com.sg name: Yie H Lau role: PRINCIPAL_INVESTIGATOR lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06355544 id: PINEAPPL2023 id: 2023-A02494-41 type: OTHER domain: Agence nationale de sécurité du médicament et des produits de santé briefTitle: Individual Factors Related to Chronic Low-grade Inflammation and Cardiometabolic Disease Risk acronym: PINEAPPL overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-05-30 date: 2026-06-30 date: 2024-04-09 date: 2024-04-09 name: Integrative Phenomics class: INDUSTRY name: Assistance Publique - Hôpitaux de Paris name: Assistance Publique Hopitaux De Marseille name: University Hospital, Bordeaux name: Centre Hospitalier Universitaire Dijon name: Institut Pasteur de Lille name: Hopitaux Civils de Colmar briefSummary: The goal of this observational study is to learn about low-grade inflammation in healthy individuals and individuals with overweight or obesity.
2. Complete questionnaires and collect a stool sample at home. conditions: Overweight conditions: Obesity conditions: Metabolic Syndrome conditions: Healthy conditions: Low-grade Inflammation conditions: Normal Weight Adults conditions: Risk Factor, Cardiovascular conditions: Hypertension conditions: Hypercholesterolemia conditions: Abdominal Obesity conditions: Metabolically Healthy Controls studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 3000 type: ESTIMATED measure: Low-grade inflammation measure: Gut microbiome metabolites measure: Fasting glucose measure: Stool microbiome composition measure: Stool microbiome functional pathways measure: Systolic blood pressure measure: Resting heart rate measure: Serum glycated hemoglobin (HbA1c) measure: Diastolic blood pressure measure: Height measure: Waist circumference measure: Neck circumference measure: Hip circumference measure: Body fat mass measure: Water body mass measure: Lean body mass measure: Serum fasting low-density lipoprotein measure: Fasting serum high-density lipoprotein measure: Fasting total serum cholesterol measure: Consumption of dietary macronutrients measure: Consumption of dietary micronutrients measure: Consumption of dietary metabolites measure: Food item consumption measure: Food group consumption measure: Body weight measure: Serum Alanine Transaminase (ALT) measure: Serum Aspartate Aminotransferase (ALT) measure: Serum gamma-glutamyl transferase (GGT) measure: Fasting serum triglycerides measure: Fasting serum uric acid measure: Fasting serum creatinine measure: Fasting serum insulin measure: Blood hemoglobin measure: Blood hematocrit measure: Red blood cells measure: Red blood cell volume measure: Hemoglobin relative red blood cell size measure: Mean cell hemoglobin (MCH) measure: Blood platelets measure: White blood cells measure: Perceived quality of life measure: Eating behavior measure: Physical activity measure: Stool consistency measure: Stress measure: Deprivation measure: Sleep measure: Sleep apnea sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06355531 id: FNP223-CT-2301 briefTitle: A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP) overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-11 date: 2026-11 date: 2024-04-09 date: 2024-04-09 name: Ferrer Internacional S.A. class: INDUSTRY briefSummary: PROSPER trial is a trial to assess the efficacy of FNP-223 in slowing disease progression in participants with PSP as measured by the PSP Rating Scale (PSPRS) over 52 weeks and to assess the safety and tolerability of FNP-223 for 52 weeks in participants with PSP. conditions: Progressive Supranuclear Palsy studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 220 type: ESTIMATED name: FNP-223 name: Placebo measure: Change From Baseline to Week 52 in the PSPRS Outcome measure: Number of Participants Experiencing Treatment-emergent Adverse Events (TEAEs) measure: Number of Participants Experiencing Serious Adverse Events (SAEs) measure: Change From Baseline to Week 52 in Clinical Global Impression of Severity Scale (CGI-S) measure: Change From Baseline to Week 52 Participant Global Impression of Severity Scale (PGI-S) measure: Change From Baseline to Week 52 in Caregiver Global Impression of Severity Scale (CaGI-S) measure: Slope of Decline in PSPRS measure: Change From Baseline to Week 52 in Individual Subitems of PSPRS measure: Change From Baseline to Week 52 in Schwab and England Activities of Daily Living Scale measure: Change From Baseline to Week 52 in PSP Clinical Deficits Scale (PSP-CDS) measure: Change From Baseline to Week 52 in Montreal Cognitive Assessment (MoCA) measure: Change From Baseline to Week 52 in PSP Quality of Life Scale (PSP-QoL) measure: Pharmacokinetic characterization of FNP-223 sex: ALL minimumAge: 50 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False