hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06388096 id: PERGCLAD001 briefTitle: CLAD Deconvolved PERG Responses in Glaucoma Patients overallStatus: RECRUITING date: 2023-06-01 date: 2025-06-01 date: 2025-06-01 date: 2024-04-29 date: 2024-04-29 name: Jorvec Corp. class: INDUSTRY name: University of Miami briefSummary: Glaucoma is a progressive disease resulting in blindness. Determining the onset of the disease is critical so patients may obtain treatment to preserve useful vision. This study will collect data from a population of glaucoma suspects (with positive factors for the disease but with normal vision) along with a population of age matched controls using the pattern electroretinogram (PERG) and other standard eye tests for glaucoma. The PERG measures the function of retinal ganglion cells (RGCs) which come together to form the optic nerve. RGCs may become dysfunctional before dying. The Continuous loop deconvolution technique (CLAD) will be used to extract transient PERG responses in both glaucoma suspects and age matched controls. All patients will be monitored with PERG, Optic Coherence Tomography (OCT) and other ancillary tests over 2 years. CLAD will be compared with conventional techniques of monitoring glaucoma (standard PERG, OCT, visual field etc) to see if the CLAD is better at distinguishing between glaucoma suspects and controls. conditions: Glaucoma, Suspect studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 120 type: ESTIMATED name: No Intervention Provided measure: PERG Amplitude measure: PERG Latency sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Miami, Bascom Palmer Eye Institute 900 NW 17th Street status: RECRUITING city: Miami state: Florida zip: 33136 country: United States name: Vittorio Porciatti, MD/PhD role: CONTACT email: vporciatti@med.miami.edu lat: 25.77427 lon: -80.19366 hasResults: False
nctId: NCT06388083 id: LBS-008-CT07 briefTitle: A Phase 2/3 Study to Evaluate the Efficacy and Safety of Tinlarebant in Subjects With Stargardt Disease acronym: DRAGON II overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2027-06 date: 2027-07 date: 2024-04-29 date: 2024-04-29 name: Belite Bio, Inc class: INDUSTRY briefSummary: The goal of this clinical trial is to evaluate the safety, tolerability, and efficacy of tinlarebant in subjects with Stargardt Disease conditions: STGD1 conditions: Stargardt Disease 1 studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: Tinlarebant name: Placebo measure: To measure the annualized rate of change from baseline lesion size in aggregate area of atrophy measure: To measure the annualized rate of change in total area of atrophy measure: Change in BCVA measured by the ETDRS method sex: ALL minimumAge: 12 Years maximumAge: 20 Years stdAges: CHILD stdAges: ADULT facility: Belite Study Site city: Dallas state: Texas zip: 75231 country: United States lat: 32.78306 lon: -96.80667 hasResults: False
nctId: NCT06388070 id: HUC3-053 briefTitle: To Evaluate the Efficacy and Safety of HUC3-053 in Patients With Dry Eye Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-03 date: 2025-04 date: 2024-04-29 date: 2024-04-29 name: Huons Co., Ltd. class: INDUSTRY briefSummary: This is a multi-center, randomized, double-blinded, non-inferiority study to evluate the efficacy and safety of HUC3-053 in patients with dry eye syndrome.
After a 2-week run-in period, patients will be randomized equally to the HUC3-053 or Hyalein Mini Drops administered bilaterally five to six times a day for 12 weeks. conditions: Dry Eye Syndromes studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 280 type: ESTIMATED name: HUC3-053 name: Hyalein Mini Drops measure: Change from Baseline in Corneal staining score measure: Change from Baseline in Corneal staining score measure: Change from Baseline in Conjunctival staining score measure: Change from Baseline in Schirmer test measure: Change from Baseline in Tear film break-up time measure: Change from Baseline in Ocular surface disease index measure: Change from Baseline in Soreness after eye drop assessed by NRS sex: ALL minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06388057 id: 5836 briefTitle: Intraoperative Ultrasound in Crohn's Disease overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-06-30 date: 2025-09-01 date: 2024-04-29 date: 2024-04-29 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: To study the role of intraoperative ultrasound of small bowel as a possible tool that can reduce the rate of histologically involved resection margins from Crohn's Disease. conditions: Crohn Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Patients with Crohn's disease with an indication for surgery primaryPurpose: DIAGNOSTIC masking: NONE count: 100 type: ESTIMATED name: Intraoperative Small Bowel Ultrasonography measure: Specificity and sensibility of intraoperative ultrasound of small bowel in identifying resection margins histologically involved by Crohn's disease sex: ALL minimumAge: 12 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06388044 id: PRO00115010 briefTitle: ACT for Infertility: Case Series overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-04-29 date: 2024-04-29 name: Duke University class: OTHER briefSummary: In the United States, around 19% of reproductive-aged couples suffer from infertility. The psychological distress associated with infertility is well-established; those diagnosed commonly experience depression and anxiety symptoms, diminished quality of life, and relationship dissatisfaction. In the current study, the investigators report on a case series, in which up to 10 infertility patients will receive 12 sessions of Acceptance and Commitment Therapy (ACT). The overarching goal for the current case series is to determine whether ACT might be well-suited for infertility patients experiencing distress. The specific aims are: 1) to describe the components of the intervention that was delivered; 2) to determine the extent to which infertility patients perceive a 12-session ACT intervention beneficial and acceptable; 3) to describe change in mood, stress, and ACT processes across 12 sessions of ACT; and 4) to highlight potential processes through which ACT might promote benefits to the patient by describing how change in mood, stress, and ACT processes relate to each other over the course of 12 sessions of ACT. conditions: Infertility conditions: Psychological Distress conditions: Acceptance and Commitment Therapy conditions: Psychological Flexibility studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: Acceptance and Commitment Therapy measure: Acceptability of the Intervention measure: Change in Fertility Problem Inventory (FPI) measure: Change in Patient Health Questionnaire 9 (PHQ-9) measure: Change in Patient Health Questionnaire 2 (PHQ-2) measure: Change in Generalized Anxiety Disorder Questionnaire 7 (GAD-7) measure: Change in Generalized Anxiety Disorder Questionnaire 2 (GAD-2) measure: Change in Modified Differential Emotions Scale (mDES) measure: Change in Comprehensive Assessment of Acceptance and Commitment Therapy (CompACT-15) measure: Change in Intolerance of Uncertainty (IUS) measure: Change in Valuing Questionnaire (VQ) measure: Change in Values-Based Behavior sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Duke North Pavilion city: Durham state: North Carolina zip: 27705 country: United States name: Francesca Scheiber, PhD role: CONTACT phone: 919-668-8696 email: fs158@duke.edu name: Julia Woodward, PhD role: SUB_INVESTIGATOR name: Ashley Moskovich, PhD role: SUB_INVESTIGATOR lat: 35.99403 lon: -78.89862 hasResults: False
nctId: NCT06388031 id: CAPTRAL2024v1 briefTitle: ICI Rechallenge for Advanced NSCLC With Long-Term Response to First-Line ICI overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2027-01-10 date: 2027-12-10 date: 2024-04-29 date: 2024-04-29 name: Peking Union Medical College Hospital class: OTHER briefSummary: An exploratory phase II trial of immune checkpoint inhibitors (ICIs, anti-PD-1/anti-PD-L1) as second-line treatment with advanced non-small cell lung cancer (NSCLC) who had long-term response to first-line immunotherapy (with or without chemotherapy).
This study aims to evaluate efficacy and safety of ICI rechallenge in long-term responders to prior ICI. Furthermore, it seeks to identify biomarkers capable of predicting the efficacy of immunotherapy and prognosis. conditions: Non-small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 27 type: ESTIMATED name: Immune checkpoint inhibitor measure: Progression Free Survival (PFS) measure: Overall Survival (OS) measure: Objective Response Rate (ORR) measure: Progression Free Survival 2 (PFS 2) measure: Safety profile sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking Union Medical College Hospital city: Beijing zip: 100730 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06388018 id: NRG-GY032 id: NCI-2023-09355 type: REGISTRY domain: CTRP id: CCTG EN.10 type: OTHER domain: CCTG id: U10CA180868 type: NIH link: https://reporter.nih.gov/quickSearch/U10CA180868 briefTitle: Tailoring Therapy in Post-surgical Patients With Low-risk Endometrial Cancer overallStatus: SUSPENDED date: 2024-04-16 date: 2025-01-09 date: 2025-01-09 date: 2024-04-29 date: 2024-04-29 name: NRG Oncology class: OTHER name: National Cancer Institute (NCI) name: Canadian Cancer Trials Group briefSummary: This phase II trial tests how well tailoring therapy in post-surgery works in patients with low-risk endometrial cancer. The usual approach for patients with low-risk endometrial cancer is treatment with surgery. In this study, tissue that is removed as part of the surgical procedure is analyzed in the pathology laboratory to help guide the doctor to decide whether or not additional treatment such as radiation and or chemotherapy should be recommended. conditions: Stage I Uterine Corpus Endometrial Stromal Sarcoma AJCC V8 conditions: Stage II Uterine Corpus Endometrial Stromal Sarcoma AJCC V8 conditions: Stage III Uterine Corpus Endometrial Stromal Sarcoma AJCC V8 studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 325 type: ESTIMATED name: Clinical Observation name: External Beam Radiation Therapy name: High-Dose-Rate Vaginal Brachytherapy name: Computed Tomography name: Positron Emission Tomography name: X-Ray Imaging name: Magnetic Resonance Imaging name: Questionnaire Administration measure: Time to pelvic recurrence measure: Time to isolated vaginal recurrence measure: Recurrence-free survival measure: Endometrial cancer-specific survival measure: Fear of recurrence sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Washington University School of Medicine city: Saint Louis state: Missouri zip: 63110 country: United States lat: 38.62727 lon: -90.19789 hasResults: False
nctId: NCT06388005 id: 2021-060 briefTitle: The Application of Emotion Release Technology in Anxiety Patients Before Daytime Thyroid Surgery overallStatus: COMPLETED date: 2022-03-01 date: 2022-07-31 date: 2022-07-31 date: 2024-04-29 date: 2024-04-29 name: Yantai Yuhuangding Hospital class: OTHER briefSummary: Research methods
2 Intervention method of the control group The control group was given routine nursing. After entering the pre-anesthesia room, the patients were scored using the VAS-A, and those with VAS-A score ≥ 5 were considered to meet the inclusion criteria. After identity authentication, the preoperative precautions and reasons for waiting in the pre-anesthesia room were explained to the patients, and answers were provided to the questions raised by the patients. After routine nursing, VAS-A score was recorded, blood pressure and heart rate were monitored, and nursing satisfaction was inquired. The survey of patient satisfaction with nursing was completed before entering the operating room.
3.2 Operating instructions The acupoint diagram was distributed to the experimental group by nurses, and the essentials and precautions of acupoint tapping were explained. The nurses demonstrated and tapped the acupoints on the patients while explaining, and then instructed them to tap on their own until they were able to complete the task independently and proficiently. For patients with upper limb vein puncture, proper fixation and close observation were needed, and the flexible nature of the puncture needle that would not affect operations was explained to the patients to eliminate their concerns.
1. Preparation stage The patients with VAS-A score ≥ 5 meeting the inclusion criteria were in a comfortable position with eyes closed, and adopted breathing exercise to relax their whole body. The patients were guided to summarize the main current distresses, such as fear, tension, pain, surgical prognosis, economic burden, etc., name the caused negative emotions, and use the SUDS to evaluate the intensity of negative emotions. The patients were asked to recite silently the prompt "Although I am very \*\* (a negative emotional word) now, I still deeply and completely love and accept myself" while tapping.
2. Tapping stage The patients were guided to gently massage the sore points on both sides of the body (2-3 fingers below the midpoint of the clavicle) with their five fingers together in a clockwise direction, while silently reciting the prompt 3 times. Then, the patients were guided to close their index and middle fingers together and gently tap the Zanzhu, Tongziliao, Chengqi, Renzhong, Chengjiang, Shufu, Dabao and Baihui acupoints successively with their fingertips at 2-3 times/s and the force they can bear. The prompt was recited silently when tapping each acupoint. After 3-5 rounds of tapping, 3 deep breaths were taken to re-evaluate the intensity of negative emotions.
3. Feedback stage After tapping, the patients communicated with the nurses at least once about their evaluated negative emotional intensity score and whether the score was accepted. If the tapping effect was not obvious, the evaluation was conducted by nurses, and the patients were guided to massage the sore points while silently reciting the prompt 3 times. To relieve reverse psychological drive, tapping was continued until the intensity of negative emotions reduced. conditions: Anxiety conditions: Day Surgery conditions: Preoperative Nursing Care conditions: Emotional Freedom Technique studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 237 type: ACTUAL name: emotional freedom technique (EFT) measure: VAS-A score measure: hemodynamic and endocrine indicators measure: nursing satisfaction sex: ALL minimumAge: 18 Years maximumAge: 64 Years stdAges: ADULT facility: Yantai Yuhuangding Hospital city: Yantai state: Shandong zip: 264000 country: China lat: 37.47649 lon: 121.44081 hasResults: False
nctId: NCT06387992 id: PP24023 briefTitle: Evaluation of the Agreement Between a Consultation With a Nurse Acquiring Three-dimensional Intraoral Images Made With a 3D Intraoral Camera and the Standard Consultation With a Dental Surgeon, in Institutionalized Elderly Subjects acronym: GEROdonto3D overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2027-06-01 date: 2027-06 date: 2024-04-29 date: 2024-04-29 name: CHU de Reims class: OTHER briefSummary: The primary objective of this study will be to assess the agreement between a dental consultation with a nurse acquiring intraoral images, using a 3D intraoral camera, and a standard consultation with a dental surgeon, in institutionalized elderly subjects Institutionalized subjects planned to have a dental consultation and eligible will be included once written informed consent is signed. Their dental consultation will start with a consultation with a nurse to record 3D intraoral images, then a consultation with a dental surgeon for standard dental care, blinded from the nurse consultation will be performed. Thereafter, 3D images will be analyzed by another dental surgeon blinded from the results of both consultations. Agreement on different outcomes between the analysis of the images acquired by the nurse and the standard dental evaluation by a dental surgeon will be assessed.
Indeed, training nursing home nurses to acquire 3D dental images would enable the identification of patients in need of immediate dental care and thus extend the possibilities of access to consultations with a dentist for these patients. This would increase the efficiency of care. conditions: Dental Care for Institutionalized Elderly Persons studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 50 type: ESTIMATED name: Three-dimensional dental acquisition measure: DMFT index measure: Plaque control record measure: General Oral Health Assessment Index (GOHAI) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Damien JOLLY city: Reims country: France name: Carole ETIENNOT role: CONTACT phone: 03 10 73 66 79 phoneExt: 0033 email: cetiennot@chu-reims.fr lat: 49.25 lon: 4.03333 hasResults: False
nctId: NCT06387979 id: 19-010725 id: NCI-2024-01000 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: 19-010725 type: OTHER domain: Mayo Clinic in Florida id: P30CA015083 type: NIH link: https://reporter.nih.gov/quickSearch/P30CA015083 id: R33CA240181 type: NIH link: https://reporter.nih.gov/quickSearch/R33CA240181 briefTitle: Advanced Development of Desorption Electrospray Ionization Mass Spectrometry for Intraoperative Molecular Diagnosis of Brain Cancer Using Pathology Biopsies overallStatus: RECRUITING date: 2020-10-26 date: 2025-10-15 date: 2025-10-15 date: 2024-04-29 date: 2024-04-29 name: Mayo Clinic class: OTHER name: National Cancer Institute (NCI) briefSummary: This study explores whether DESI-MS can be used to identify cancerous vs. noncancerous tissue during brain tumor surgery. conditions: Glioma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 185 type: ESTIMATED name: Non-Interventional Study measure: Pathological state of the tissue measure: Percentage of tumor infiltration measure: Presence of IDH mutations sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mayo Clinic in Florida status: RECRUITING city: Jacksonville state: Florida zip: 32224-9980 country: United States name: Clinical Trials Referral Office role: CONTACT phone: 855-776-0015 email: mayocliniccancerstudies@mayo.edu name: Alfredo Quinones-Hinojosa, M.D. role: PRINCIPAL_INVESTIGATOR lat: 30.33218 lon: -81.65565 hasResults: False
nctId: NCT06387966 id: H-FNTN-PI-Ia briefTitle: A Randomized, Double-blind,Dose-escalating, Single-dose, Oral Phase I Clinical Study of Flunotinib Healthy People overallStatus: RECRUITING date: 2024-02-29 date: 2024-08-29 date: 2024-12-30 date: 2024-04-29 date: 2024-04-29 name: Chengdu Zenitar Biomedical Technology Co., Ltd class: INDUSTRY briefSummary: Evaluate the safety and tolerability of a single increasing dose of Flibanserin Maleate tablets administered orally to healthy adult Chinese subjects; preliminarily assess the pharmacokinetic characteristics of a single dose of oral Flibanserin Maleate tablets conditions: Healthy Person studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: flunotinib name: flunotinib placebo measure: Prilinostat Mesylate Pharmacokinetics (PK)：Cmax measure: Prilinostat Mesylate Pharmacokinetics (PK)：Tmax measure: The statistical parameters of fecal pharmacokinetics are the cumulative excretion of prototype drugs and major metabolites in feces (Ae0-144h) and excretion rate (Ae%); measure: Prilinostat Mesylate Pharmacokinetics (PK)：AUC0-∞ measure: Prilinostat Mesylate Pharmacokinetics (PK)：MRT measure: Prilinostat Mesylate Pharmacokinetics (PK)：Vd measure: Prilinostat Mesylate Pharmacokinetics (PK)：t1/2 measure: Prilinostat Mesylate Pharmacokinetics (PK)：CLz/F measure: Prilinostat Mesylate Pharmacokinetics (PK)：Vz/F measure: Prilinostat Mesylate Pharmacokinetics (PK)：Ke sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Chengdu Xinhua Hospital status: RECRUITING city: Chengdu state: Sichuan zip: 610000 country: China name: Xiaolan Yong, bachelor role: CONTACT phone: 13568843829 email: yongxlan@126.com lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06387953 id: STUDY00019480 briefTitle: Mitigation of Emergence Agitation Through Implementation of Masimo Bridge Therapy overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-06 date: 2025-06 date: 2024-04-29 date: 2024-04-29 name: University of Washington class: OTHER briefSummary: This is a randomized, prospective, double-blinded (patient and outcome-assessor) trial. Our goal is to assess efficacy of Bridge Therapy (versus sham bridge therapy) to prevent emergence agitation following general anesthesia.
Tertiary Objective: Activation of Bridge Therapy during a stable anesthetic state is associated with a reduced Patient State Index as measured on Sedline conditions: Emergence Delirium conditions: Agitation, Emergence studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Bridge Therapy name: Sham Therapy measure: Emergence agitation measure: Emergence agitation measure: Rescue pharmacologic treatment of agitation measure: Patient State Index sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06387940 id: UEC 2019 008 FHMS briefTitle: Acute Metabolic Effects of Carbohydrate Restriction at Varying Energy Levels overallStatus: COMPLETED date: 2019-11-05 date: 2020-04-01 date: 2022-11-20 date: 2024-04-29 date: 2024-04-29 name: University of Surrey class: OTHER briefSummary: This study investigates how different low-carbohydrate diets affect metabolism and hunger in overweight adults. We will measure metabolic rates and blood metabolites. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 12 type: ACTUAL name: nEB Diet, followed for 36 hours name: LC25 Diet, followed for 36 hours name: LCEB Diet, followed for 36 hours measure: Biomarkers in blood Measured measure: Resting metabolic rate measure: Perceived Appetite Scores measure: Food intake sex: ALL minimumAge: 20 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Surrey city: Guildford zip: GU2 7XH country: United Kingdom lat: 51.23536 lon: -0.57427 hasResults: False