hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06279299 id: LLND briefTitle: Lateral Pelvic Lymph Node Dissection for Rectal Neuroendocrine Neoplasms Undergoing Laparoscopic Total Mesenteric Excision overallStatus: RECRUITING date: 2022-08-01 date: 2028-08-01 date: 2028-08-01 date: 2024-02-28 date: 2024-02-28 name: National Cancer Center, China class: OTHER briefSummary: The purpose of this study is to investigate the metastatic status of lateral pelvic lymph nodes in rectal neuroendocrine neoplasms (rNENs) undergoing laparoscopic total mesenteric excision (TME). The hypothesis is that the rate of lateral lymph node metastasis is underestimated in rNENs undergoing TME, necessitating concurrent lateral Pelvic lymph node dissection. conditions: Rectal Neuroendocrine Neoplasm studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: lateral pelvic lymph node dissection measure: The rate of lateral pelvic lymph node metastasis measure: The rate of lymph node metastasis measure: Disease-free survival rate measure: Overall survival rate measure: Locoregional recurrence free survival rate measure: Radical resection (R0) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Cancer Center status: RECRUITING city: Beijing state: Beijing zip: 100000 country: China name: Haitao Zhou, M.D. role: CONTACT phone: +8613381167333 email: zhouhaitao01745@163.com name: Yueyang Zhang, M.D. role: CONTACT phone: +8613552910035 email: yyzhang0129@163.com lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06279286 id: HS-10506-201 briefTitle: Phase Ⅰb/Ⅱ Study of HS-10506 in Chinese Participants With Insomnia Disorder overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-01 date: 2025-01 date: 2024-02-28 date: 2024-04-23 name: Jiangsu Hansoh Pharmaceutical Co., Ltd. class: INDUSTRY briefSummary: The primary purpose of this phase Ⅰb/Ⅱ study is to investigate the safety, tolerability, pharmacokinetics (the study of the way a drug enters and leaves the blood and tissues over time) after multiple dose administration and the efficacy of HS-10506 (change versus placebo) on latency to persistent sleep (LPS) measured by polysomnography (PSG) in Chinese adult participants with insomnia disorder. conditions: Insomnia Disorder studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 312 type: ESTIMATED name: HS-10506 name: Placebo measure: Incidence and severity of adverse events (AE) measure: Incidence and severity of serious adverse events (SAE) measure: Changes in laboratory test before and after drug administration measure: Changes in ECG before and after drug administration measure: Changes in Karolinska Sleepiness Scale (KSS) scores before and after drug administration measure: Change from baseline in the mean LPS measured by PSG on Night 13 and Night 14 measure: The maximum plasma concentration (C[max]) measure: Time to reach the maximum plasma concentration (T[max]) measure: Area under the plasma concentration-time curve from time zero to last time of quantifiable concentration (AUC[0-t]) measure: Terminal elimination half-life (t1/2) measure: Change in latency to persistent sleep (LPS) relative to baseline on night 5 of PSG monitoring measure: Change in Wake After Sleep Onset (WASO) relative to baseline on night 5 of PSG monitoring measure: Change from baseline in mean LPS measured by PSG measure: Change from baseline in mean TST measured by PSG measure: Change from baseline in mean WASO measured by PSG measure: Change from baseline in the mean values of self-reported sleep-onset latency (sSOL) recorded in the sleep diary measure: Change from baseline in the mean values of self-reported total sleep time (sTST) recorded in the sleep diary measure: Incidence and severity of adverse events (AE) measure: Incidence and severity of serious adverse events (SAE) sex: ALL minimumAge: 18 Years maximumAge: 64 Years stdAges: ADULT facility: Xuanwu Hospital Capital Medical University city: Beijing country: China name: yuping Wang, PhD role: CONTACT email: wangyuping01@sina.cn lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06279273 id: NZhong-005 briefTitle: A Study for the Risky Decision-making Deficits Among Methamphetamine Dependence Individuals and Treatment overallStatus: ACTIVE_NOT_RECRUITING date: 2023-01-01 date: 2024-07-31 date: 2025-12-31 date: 2024-02-28 date: 2024-02-28 name: Shanghai Mental Health Center class: OTHER name: Wuhan Mental Health Centre name: Wuhan Judicial Bureau Hanyang Compulsory Isolated Detoxification Center briefSummary: The risky decision-making deficits is the core feature of the methamphetamine (MA) dependence. Our previous research found that MA dependents have network abnormalities such as decision-making and rewarding. The feedback-related negativity amplitude in the prefrontal central area of MA users becomes smaller and blunted after a loss. Moreover, the neural modulation over the prefrontal cortex showed potent to decrease the craving, and the functional connectivity between frontal cortex and subparietal lobules increases. It suggests that there is a correlation between the decision-making network and the reward network of MA addicts, but there is no real-time observation of the dynamic changes of these brain network activities, so it is difficult to correct the interaction mechanism.
In order to clarify the dynamic brain network mechanism of the risky decision-making deficits among MA dependents, firstly, based on magneto-encephalography source information reconstruction methods, firstly, based on magneto-encephalography source information reconstruction methods, the investigators will observe the sequence and interaction among decision-making network, rewarding network, and emotion network. Besides, the investigators clarify that the trans-cranial current stimulation over prefrontal cortex could improve the speed and intensity of the key network interactions among MA dependents, which could improve risky decision-making and craving. The successful implementation of the study is expected to provide important clues for elucidating the pathological mechanism of risky decision-making deficits in MA dependents and providing a theoretical basis for the treatment of addiction. conditions: Methamphetamine Use Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Transcranial direct current stimulation measure: Frontal lobe activation level measure: cue-induced craving measure: Cognitive function measure: Attention bias towards methamphetamine sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Shanghai Mental Health Center city: Shanghai country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06279260 id: 2023.295RMH21343Protocol_V2.0 briefTitle: National Robotics-Assisted Radical Prostatectomy Database overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2029-12 date: 2030-12 date: 2024-02-28 date: 2024-04-25 name: Melbourne Health class: OTHER name: Peter MacCallum Cancer Centre, Australia name: Epworth Healthcare name: St Vincent's Hospital name: Austin Health briefSummary: Surgical notes are detailed reports written by surgeons during and after surgeries. These notes cover everything from the techniques, instruments used, any issues with the surgical procedure and post-surgical care for the patient. This information is a treasure trove for researchers because they can study it to understand how surgeries go, what works best, and how certain treatments affect patients.
To address this issue, we aim to create a database that collects information from surgical notes effortlessly. This includes details about how surgeons are trained and how they progress. It's important to make sure that doctors work aligns with research - which is the best way to address data collection issues. This data can also help record different technical aspects of surgery and different surgeons' learning curve, making it easier to compare and improve training. Thus, we aim to standardise notes that are the same across different hospitals conducting robotic-assisted surgeries for prostatectomy. conditions: Database conditions: Prostate Cancer conditions: Robotic-assisted Radical Prostatectomy conditions: Surgical Outcomes conditions: Oncological Outcomes conditions: Patient Reported Outcome Measures conditions: Learning Curve studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 10000 type: ESTIMATED measure: To provide a standardized framework, enabling robust evidence strengthening & analyses, trend identification, and the formulation of evidence-based guidelines for the individualized management of PCa. measure: Patient reported quality of life outcome measures measure: Surgical measure: Oncological sex: MALE minimumAge: 16 Years maximumAge: 90 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Austin Healthcare city: Melbourne state: Victoria zip: 2084 country: Australia name: Damien Bolton role: CONTACT lat: -37.814 lon: 144.96332 facility: E.J Whitten Prostate Cancer Centre, Epworth Healthcare city: Melbourne state: Victoria zip: 3002 country: Australia lat: -37.814 lon: 144.96332 facility: St. Vincent's Private Hospital city: Melbourne state: Victoria zip: 3002 country: Australia name: Lih-Ming Wong role: CONTACT lat: -37.814 lon: 144.96332 facility: Peter MacCallum Cancer Centre city: Melbourne state: Victoria zip: 3050 country: Australia name: Marlon Perara role: CONTACT lat: -37.814 lon: 144.96332 facility: Royal Melbourne Hospital city: Melbourne state: Victoria zip: 3050 country: Australia name: Nathan Lawrentschuk role: CONTACT lat: -37.814 lon: 144.96332 hasResults: False
nctId: NCT06279247 id: KYLL-202212-011 briefTitle: Proteomics and Metabolomics of Body Fluid in Patients With Narcolepsy overallStatus: RECRUITING date: 2022-09-01 date: 2024-09 date: 2024-09 date: 2024-02-28 date: 2024-03-15 name: Qilu Hospital of Shandong University class: OTHER briefSummary: Narcolepsy (NRL) is a rare chronic central nervous system dysfunction disease, which is more common in children and adolescents, and less common in adults. Its typical clinical features include excessive daytime sleep, paroxysmal cataplexy, sleep paralysis and sleep hallucination. In addition to the above typical manifestations, patients with narcolepsy can also manifest as hyperappetite, weight gain, multiple dreams, sleep fragmentation, anxiety and depression and other emotional disorders. In particular, in narcolepsy type 1 with cataplexy, cataplexy episodes can be confused with falls caused by seizures, transient ischemic attacks or neuromuscular disorders, or even mental conversion disorders. Due to its diverse clinical symptoms, it is easy to be missed and misdiagnosed.
At present, the pathogenesis of narcolepsy is still unclear, and its pathogenesis may be related to immune, genetic, environmental, infection, central nervous system degeneration and other factors. This study aims to investigate the changes of body fluid proteomics and metabolomics in patients with narcolepsy, and to provide an important basis for the pathogenesis of narcolepsy. conditions: Narcolepsy studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 60 type: ESTIMATED measure: To screen potential molecular markers related to the biological characteristics and prognosis of narcolepsy. sex: ALL minimumAge: 5 Years maximumAge: 100 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Qilu Hospital of Shandong University status: RECRUITING city: Jinan state: Shandong zip: 250012 country: China name: Wenjing Jiang role: CONTACT phone: 18560082210 email: jiangwenjing@qiluhospital.com lat: 36.66833 lon: 116.99722 hasResults: False
nctId: NCT06279234 id: C4001002 briefTitle: A Study to Learn How Different Amounts of PF-06954522 Are Tolerated and Act in Adults With Type 2 Diabetes Mellitus overallStatus: RECRUITING date: 2024-02-20 date: 2024-12-31 date: 2024-12-31 date: 2024-02-28 date: 2024-04-11 name: Pfizer class: INDUSTRY briefSummary: The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of multiple escalating oral doses of PF-06954522 in adult participants with inadequately controlled type 2 diabetes mellitus (T2DM) on metformin (Part A) and optionally in non-diabetic participants with obesity (Part B). conditions: Type 2 Diabetes Mellitus (T2DM) conditions: Obesity studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: NONE count: 122 type: ESTIMATED name: Placebo name: Rosuvastatin name: Midazolam name: Omeprazole name: PF-06954522 measure: Number of Participants Reporting Adverse Events measure: Number of Participants with Clinically Significant Change From Baseline in Laboratory Abnormalities measure: Number of Participants With Clinically Significan Change From Baseline in Vital Signs measure: Number of Participants With Clinically Significant Change From Baseline in 12-Lead ECGs measure: Number of Participants with categorical scores on the Columbia Suicide Severity Rating Scale (C-SSRS) measure: Number of Participants With Change From Baseline in Physical Examination measure: Maximum Observed Plasma Concentration (Cmax) measure: Area Under the Curve from Time Zero to end of dosing interval (AUCtau) measure: Time to Reach Maximum Observed Plasma Concentration (Tmax) measure: Plasma Decay Half-Life (t1/2) measure: Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) measure: Percentage of Dose of PF-06751979 Excreted Unchanged in the Urine Over the Dosing Interval Tau (Aetau%) measure: Renal Clearance (CLr) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Anaheim Clinical Trials, LLC status: RECRUITING city: Anaheim state: California zip: 92801 country: United States lat: 33.83529 lon: -117.9145 facility: Qps-Mra, Llc status: RECRUITING city: South Miami state: Florida zip: 33143 country: United States lat: 25.7076 lon: -80.29338 hasResults: False
nctId: NCT06279221 id: B7981055 briefTitle: Litfulo Capsules Special Investigation overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2030-06-25 date: 2030-06-25 date: 2024-02-28 date: 2024-02-28 name: Pfizer class: INDUSTRY briefSummary: The objective of this Study is to confirm the safety during the long-term use of this drug and the effectiveness during the use of this drug under the actual use in the patients treated with this drug. conditions: Alopecia Areata studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 850 type: ESTIMATED name: LITFULO measure: Proportion of participants with adverse events (AEs) measure: Percentage of patients achieving SALT≤20 [SALT score (absolute value) 20 or less] sex: ALL minimumAge: 12 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06279208 id: 2023-A00272-43 briefTitle: Phosphoproteomic Profile of Children With Down Syndrome acronym: PEPS overallStatus: RECRUITING date: 2024-03-18 date: 2024-09 date: 2024-09 date: 2024-02-28 date: 2024-04-01 name: Perha Pharmaceuticals class: INDUSTRY name: Proteas Bioanalytics name: Göteborg University briefSummary: One of the major causes of cognitive disorders limiting the learning abilities of children with Down's syndrome is excess activity of the DYRK1A protein kinase, whose gene is located on chromosome 21. Consequently, variations in the level of phosphorylation, and hence activity, of DYRK1A target proteins involved in synaptic transmission, could identify mechanisms underlying these cognitive disorders.
Several studies have shown that plasma proteins can reflect a pathophysiological brain state. The investigators plan to carry out a phosphoproteomic study to determine the phosphorylation profile of plasma proteins in children with Down's syndrome, and identify potential DYRK1A-dependent pathophysiological mechanisms and biomarkers involved in the natural course of cognition in children with Down's syndrome. conditions: Down Syndrome studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: Blood sample measure: Phosphoproteomic profile measure: Identification of brain proteins measure: Impact of environnement on phosphoproteomic profile measure: Impact of DYRK1A on Down Syndrome specific proteomic profile sex: MALE minimumAge: 6 Years maximumAge: 12 Years stdAges: CHILD facility: CHU Grenoble status: NOT_YET_RECRUITING city: Grenoble country: France name: Dr Marey role: CONTACT phone: 0476767285 lat: 45.16667 lon: 5.71667 facility: Hospices Civils de Lyon status: RECRUITING city: Lyon country: France name: Dr Sanlaville role: CONTACT phone: 0427855573 lat: 45.74848 lon: 4.84669 facility: Institut Jérôme Lejeune status: RECRUITING city: Paris country: France name: Dr Cieuta-Walti role: CONTACT phone: 0156586300 lat: 48.85341 lon: 2.3488 facility: CHU Rennes status: RECRUITING city: Rennes country: France name: Dr Jean-Marçais role: CONTACT phone: 0299266744 lat: 48.11198 lon: -1.67429 facility: CHU Saint-Etienne status: NOT_YET_RECRUITING city: Saint-Etienne country: France name: Dr Touraine role: CONTACT phone: 0477828116 lat: 45.43389 lon: 4.39 hasResults: False
nctId: NCT06279195 id: EH23-326 briefTitle: Phenotyping of Idiopathic Pelvic Pain With Real-time Uterine Imaging and Relugolix-Combination Therapy Treatment overallStatus: NOT_YET_RECRUITING date: 2024-04-05 date: 2025-08-02 date: 2025-08-02 date: 2024-02-26 date: 2024-02-28 name: NorthShore University HealthSystem class: OTHER name: Pfizer briefSummary: The mechanisms underlying variable efficacy of Relugolix-Combination Therapy (REL-CT) in mitigating unexplained pelvic pain will be evaluated with uterine imaging techniques and quantitative sensory testing. conditions: Pelvic Pain studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants in two groups with different conditions will be give REL-CT. primaryPurpose: BASIC_SCIENCE masking: NONE count: 60 type: ESTIMATED name: Relugolix (40 mg) /estradiol (1 mg)/norethisterone acetate (0.5 mg) oral tablet measure: Correlation between post-treatment pelvic pain and baseline uterine contraction frequency measure: Correlation between post-treatment pelvic pain and baseline sensory hypersensitivity Z-score. sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: NorthShore University HealthSystem city: Evanston state: Illinois zip: 60201 country: United States name: Kevin Hellman, PhD role: CONTACT phone: 847-570-2622 email: khellman@northshore.org lat: 42.04114 lon: -87.69006 hasResults: False
nctId: NCT06279182 id: IRB-FY2024-106 briefTitle: Impact of Barre Stretching Among Dental Hygiene Students overallStatus: NOT_YET_RECRUITING date: 2024-02 date: 2024-03 date: 2024-04 date: 2024-02-26 date: 2024-02-26 name: Idaho State University class: OTHER briefSummary: The healthcare profession of dental hygiene can be a highly stressful academic path and occupation. Physical stressors can quickly lead to postural disturbances and musculoskeletal disorders (MSDs) due to instrument grasping while under muscle tension, working with vibrating instruments, and performing repetitive micromovements. Chronic, high stress levels have the potential to lead to burnout, fatigue, and other health problems, which can impact a student's ability to perform well in their clinical rotations and didactic studies and may translate into their workforce experiences after graduation.
This study will be a 6-week experimental randomized control trial (RCT) where participants will be assigned to a 15-minute Barre stretching and breathing video two times a week for the experimental group or control group. The continuous dependent variables in this study will be the reported stress levels and reported pain levels of the entry-level dental hygiene students. The independent variable will be the Barre stretching intervention. The participants will include students at two universities enrolled in an entry-level dental hygiene program as first-year students.
Baseline data collection for each participant will be obtained, and the study will be analyzed using descriptive statistics, a paired t-test and independent t-test. The statistical significance level will be set at P=0.05. conditions: Musculoskeletal Disorders conditions: Stress Management conditions: Perceived Stress conditions: Reported Stress conditions: Perceived Pain conditions: Reported Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The experimental group will receive the Barre stretching intervention. The control group will not receive any intervention. primaryPurpose: PREVENTION masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 63 type: ESTIMATED name: Barre Stretching Intervention measure: Self-Reported Stress (Perceived Stress Scale) measure: Self-Reported Pain (Numerical Pain Rating Scale/Visual Analog Scale) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Idaho State University city: Pocatello state: Idaho zip: 83209 country: United States name: Crystal Kanderis Lane, MS role: CONTACT phone: 208-282-4209 email: crystalkanderisla@isu.edu name: Leciel Bono, PhD(s) role: CONTACT phone: (208)282-3076 email: lecielbono@isu.edu lat: 42.8713 lon: -112.44553 hasResults: False
nctId: NCT06279169 id: 2023-BRT-SBF-113355 briefTitle: The Effect of Heart Sound and White Noise on Pain and Physiological Parameters During Hepatitis B Vaccine Injection overallStatus: RECRUITING date: 2024-04-24 date: 2025-08-29 date: 2025-08-29 date: 2024-02-26 date: 2024-04-26 name: Bartın Unıversity class: OTHER briefSummary: It can cause physiological and behavioral changes in infants such as pain, tachycardia, hypoxemia, increased blood pressure, grimacing, prolonged crying, and irritability. Vaccination is an important part of neonatal nursing care. Newborns express their pain nonverbally and behaviorally. Therefore, any pain assessment is based on the ability of others to recognize pain symptoms. This randomized controlled trial was planned to evaluate the effect of heart sound and white noise on pain and physiological parameters during intramuscular injection of hepatitis B vaccine in newborns. This randomized controlled study used parallel trial design. conditions: Pain, Acute conditions: Newborn; Vitality studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 99 type: ESTIMATED name: Heart Sound name: White Noise measure: The Newborn Infant Pain Scale (NIPS) measure: oxygen saturation measure: heart rate measure: Crying Time sex: ALL minimumAge: 2 Days maximumAge: 28 Days stdAges: CHILD facility: Bartın University status: RECRUITING city: Bartın country: Turkey name: Fatma Dinç, Asst.Prof. role: CONTACT phone: +9005383555685 email: fatmadinc@bartin.edu.tr name: Aylin Kurt, Asst.Prof. role: CONTACT phone: +9005382087211 email: aylinkurt67@gmail.com lat: 41.63583 lon: 32.3375 hasResults: False