nctId: NCT06327672 id: 162023 briefTitle: INOCA Spanish National Registry acronym: ESP-INOCA overallStatus: RECRUITING date: 2024-03-24 date: 2025-03 date: 2026-03 date: 2024-03-25 date: 2024-03-28 name: Eva Rumiz González class: OTHER name: Hospital San Carlos, Madrid name: Fundación de Investigación Biomédica - Hospital Universitario de La Princesa name: Hospital Universitario Virgen de la Arrixaca name: University Hospital Gregorio Marañón name: Hospital Clínico Universitario de Valladolid name: Hospital Universitario Puerta del Mar name: Hospital Universitari de Bellvitge name: Hospital Universitario La Fe name: Hospital Clínico Universitario de Valencia name: Hospital Universitario La Paz name: Hospital General Universitario de Alicante name: Complejo Hospitalario Universitario de Huelva name: Hospital General Universitario de Castellón name: Hospital de Manises name: Hospital Clinic of Barcelona name: Hospital Miguel Servet name: Hospital Clínico Universitario Lozano Blesa name: Hospital Universitario Donostia name: Hospital General Universitario Elche name: Hospital Universitario Virgen del Rocio name: Hospital de la Ribera name: Hospital de la Santa creu i Sant Pau - Barcelona name: Hospital Virgen de la Salud name: Hospital Universitario San Juan de Alicante name: Hospital Universitario de Torrevieja name: University Hospital of the Nuestra Señora de Candelaria name: Hospital de Basurto name: Hospital Universitario Ramon y Cajal name: Hospital Universitario Fundación Jiménez Díaz name: Puerta de Hierro University Hospital name: Hospital Universitario 12 de Octubre name: University of Salamanca name: Hospital Universitario Marqués de Valdecilla name: Hospital Clinico Universitario de Santiago name: Complexo Hospitalario Universitario de A Coruña briefSummary: Coronary atherosclerosis is the most common cause of ischaemic heart disease. About 40-50% of patients with symptoms and documented ischaemia on non-invasive tests do not show obstructive coronary artery disease on coronary angiography. This cause of ischaemic heart disease called INOCA (Ischemic Non-Obstructive Coronary Artery), far from having a benign prognosis, is associated with an increase in major adverse cardiac events (MACE) as well as increased functional limitation. The current European Society of Cardiology clinical practice guidelines for the management of chronic coronary syndrome establish for the first time a IIa recommendation for the invasive analysis of coronary flow reserve (CFR) and microvascular resistance index (MRI) in symptomatic patients with INOCA. The acetylcholine (Ach) test, based on intracoronary (ic) administration, is established as indication IIb for the assessment of micro or macrovascular vasospasm in patients with suspected vasospastic angina (VSA) (4). A national multicentre registry would allow us to determine the prevalence of INOCA and its different endotypes in our setting. conditions: Non-Obstructive Coronary Atherosclerosis conditions: Ischemia conditions: Coronary Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED measure: Prevalence of INOCA endotypes. measure: Incidence of combined event: death from all causes, acute myocardial infarction, readmission for heart failure and consultation for chest pain in the emergency department. measure: Targeted pharmacological treatment measure: Prognostic markers. measure: INOCA and risk of heart failure with preserved ejection fraction. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Universitario de la Princesa status: RECRUITING city: Madrid country: Spain name: Fernando Rivero Crespo, MD role: CONTACT lat: 40.4165 lon: -3.70256 facility: Hospital Universitario Virgen de Arrixaca status: RECRUITING city: Murcia country: Spain name: Ramón Lopez Palop, MD role: CONTACT lat: 37.98704 lon: -1.13004 facility: Hospital General Universitario de Valencia status: RECRUITING city: Valencia country: Spain name: Eva Rumiz Gonzalez, MD, PhD role: CONTACT phone: +34 626068935 email: evarumizgonzalez@gmail.com lat: 39.46975 lon: -0.37739 hasResults: False