hackint0sh/New-Dataset huggingface dataset:
The study is prospective and involves the verification of performance through clinical and instrumental evaluations in the population of subjects treated with the GRAIL device at the IRCCS Medea-Bosisio Parini. conditions: Acquired Brain Injury conditions: Cerebral Palsy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Physical Rehabilitation name: Gait Real-time Analysis Interactive Lab measure: 6 minute walking test measure: Gross Motor Function Measure -total score sex: ALL minimumAge: 5 Years maximumAge: 20 Years stdAges: CHILD stdAges: ADULT facility: Scientific Institute IRCCS Eugenio Medea status: RECRUITING city: Bosisio Parini state: Lecco zip: 23842 country: Italy name: Elena Beretta, MD role: CONTACT phone: 031877851 phoneExt: +39 email: elena.beretta@lanostrafamiglia.it lat: 45.80075 lon: 9.29 hasResults: False
nctId: NCT06317506 id: RC 43/2022 briefTitle: Methylation Pattern and Pain Sensation in Children With Intellectual Disability overallStatus: COMPLETED date: 2022-05-30 date: 2023-10-10 date: 2023-10-10 date: 2024-03-19 date: 2024-03-19 name: IRCCS Burlo Garofolo class: OTHER briefSummary: Previous literature data indicate that children with intellectual disability (ID) experience more severe pain and more frequently than their cognitively healthy peers, during their daily life. Repeated and chronic pain exposure triggers a vicious circle of hyperalgesia and reduction of the impaired cognitive and adaptive function. Furthermore, these children are unable to rationalize any intervention targeted to contain potentially painful actions.
Several epigenetic studies evaluated genes coding proteins involved in recycling of neurotransmitters (SCL6A4), in transmission of painful stimuli (TRPA1) and in response to analgesics (OPRM1). In particular, some studies assessed TRPA1 gene, coding for a cationic channel responsible for the transmission of thermal-painful sensations, and SCL6A4, a serotonin-recycling transmembrane protein presents at inter-synaptic level, have highlighted the importance of methylation in a pathological experience of chronic pain and anxiety disorder in the adult population. Opioid receptor OPRM1 is involved in the endogenous and exogenous opioid-mediated analgesia and a recent work in a group of adolescents treated for idiopathic scoliosis highlights a link between greater pain post-surgery and methylation of this gene. In this context, children with ID are at greater risk of undertreatment both for the difficulty in pain recognition and for the fear of medication-adverse reactions.
The epigenetic study of the aforementioned genes in children with ID associated with an evaluation of painful experiences and clinical history, could help understanding a scenario that it is still complex nowadays before the eyes of parents and caregivers and healthcare workers.The finding of a different methylation pattern in children with ID could in part explain the different pain experience. conditions: Intellectual Disability studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 36 type: ACTUAL measure: Between groups differences in methylation levels sex: ALL minimumAge: 3 Years maximumAge: 17 Years stdAges: CHILD facility: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" city: Trieste zip: 34137 country: Italy lat: 45.64953 lon: 13.77679 hasResults: False
nctId: NCT06317493 id: RC 15/2021 briefTitle: Hearing Impairment in Children: Pupillometry and Hearing Thresholds Assessment overallStatus: RECRUITING date: 2021-01-03 date: 2024-12-31 date: 2024-12-31 date: 2024-03-19 date: 2024-03-22 name: IRCCS Burlo Garofolo class: OTHER briefSummary: The results of the previous study on auditory effort in young children with cochlear implants show that pupils respond to the presence or the absence of the perceived stimuli. The investigators hypothesize that the perceived sounds will elicit increased pupil dilation compared to the non-perceived sounds and that the hearing threshold as measured with pure tone audiometry will correlate to the results in pupillometry test. The investigators hypothesize that the effect will be visible in all testing groups albeit the relative increase of pupil size with age. Hypothesis confirmed, the investigators will develop a standardised procedure for the auditory signal detection using pupillometry. Such a procedure could represent an important bridge between automatic and behavioral hearing tests. With a more precise test of auditory threshold of young children, post-operative monitoring and fitting of cochlear implants or hearing aids, and rehabilitation procedures, could be considerably more targeted and consequentially more efficient. conditions: Hearing Impaired Children studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 180 type: ESTIMATED name: Stimuli measure: Sensitivity index of pupillometry test sex: ALL minimumAge: 4 Months maximumAge: 36 Months stdAges: CHILD facility: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" status: RECRUITING city: Trieste zip: 34137 country: Italy name: Eva Orzan, MD role: CONTACT phone: +39.040.3785.537 email: eva.orzan@burlo.trieste.it lat: 45.64953 lon: 13.77679 hasResults: False
nctId: NCT06317480 id: QH_2024 briefTitle: Outcomes Comparison Between Bone Resection and Subperiosteal Dissection for Specific Type of Soft Tissue Sarcoma overallStatus: COMPLETED date: 2000-05-01 date: 2020-05-01 date: 2023-09-01 date: 2024-03-19 date: 2024-03-19 name: Second Affiliated Hospital, School of Medicine, Zhejiang University class: OTHER briefSummary: the purpose of this study is to assess whether bone resection for thigh soft tissue sarcoma with cortical involvement of the adjacent bone result in better local control and survival compared to sub-periosteal dissection. Investigators also aim to find out the prognostic factors for clinical outcomes in this group of patients. conditions: Soft Tissue Sarcoma conditions: Cortical Contact studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 142 type: ACTUAL name: bone resection name: subperiosteal excision measure: survival measure: recurrence measure: metastasis measure: functional outcomes sex: ALL minimumAge: 8 Years maximumAge: 85 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06317467 id: RC 01/2023 briefTitle: Role of Anti-C1q Autoantibodies in Pregnancy overallStatus: RECRUITING date: 2023-09-13 date: 2026-12 date: 2026-12 date: 2024-03-19 date: 2024-03-19 name: IRCCS Burlo Garofolo class: OTHER briefSummary: Preeclampsia (PE) is a very frequent obstetric complication. C1q, the first recognition molecule of the classical pathway of complement system (C), represents a double-edged molecule in determining pregnancy outcomes. In animal models, C1q deficiency caused the development of a dysfunctional placenta and PE-like symptoms. Conversely, lower levels of C components were detected in the sera of patients with PE due to C consumption and increased deposition of activated C components in the placenta, as well as to the binding to placental apoptotic bodies, syncytiotrophoblast microvesicles (STBM) and debris which are increased in the circulation of patients with PE.
C1q is a hexameric glycoprotein of 460kDa composed by six copies of three polypeptide chains A, B and C, each made by a C-terminal globular head (gC1q) and a N-terminal collagen-like region (CLR). This molecule can be the target of an antibody response. Autoantibodies targeting C1q were first recognized in the serum of Systemic Lupus Erythematosus (SLE) patients. The presence of anti-C1q autoantibodies was also detected in patient affected by autoimmune disease (ie, kidney disorders, vasculitis, thyroiditis). Almost all of these autoimmune disorders are associated with an increased risk of developing PE during pregnancy.
Anti-C1q detection mainly concerns the prediction of the onset of lupus nephritis (LN) in SLE patients. Although anti-C1q autoantibodies do not deplete circulating C1q, their presence in maternal circulation and in placenta may trigger improper C activation and impair C1q activity. In pregnancies complicated by autoimmune affection such as SLE, autoimmune thyroid disorders and Antiphospholipid syndrome (APS) the prevalence of anti-C1q appeared to be higher than in control pregnancies and associated with miscarriage. High levels of anti-C1q have been found in a group of Japanese patients suffering recurrent pregnancy loss (RPL). In a group of anti-C1q positive healthy pregnancies and LN patients was assessed whether C1q autoantigenic behaviour could vary among individuals with or without correlated manifestation. Sera from healthy pregnancies and LN patients were screened for the presence of autoantibodies against the CLR fragment and/or the gC1q: antibodies against gC1q were found in both groups, whereas anti-CLR were only detected in the LN one, suggesting that only the latter may have a pathogenic role. Despite this, the biological functions of anti-C1q remain far from clear conditions: Pre-Eclampsia studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: OTHER count: 54 type: ESTIMATED name: Blood sampling name: Blood sampling measure: Between groups difference in percentage of anti-gC1q compared to the total anti-C1q autoantibodies measure: Between groups difference in percentage of anti-cC1q compared to the total anti-C1q autoantibodies measure: Between groups difference in percentage of anti-gC1q compared to the total anti-C1q autoantibodies measure: Between groups difference in percentage of anti-cC1q compared to the total anti-C1q autoantibodies measure: Between groups difference in percentage of anti-gC1q compared to the total anti-C1q autoantibodies measure: Between groups difference in percentage of anti-cC1q compared to the total anti-C1q autoantibodies measure: Between groups difference in percentage of anti-gC1q compared to the total anti-C1q autoantibodies measure: Between groups difference in percentage of anti-cC1q compared to the total anti-C1q autoantibodies sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" status: RECRUITING city: Trieste zip: 34137 country: Italy name: Chiara Agostinis, BSc role: CONTACT phone: 040/5588652 email: chiara.agostinis@burlo.trieste.it lat: 45.64953 lon: 13.77679 hasResults: False
nctId: NCT06317454 id: GR-2019-12369573 briefTitle: Determinants of Metabolic Control in Children With Type 1 Diabetes Mellitus overallStatus: RECRUITING date: 2021-11-11 date: 2024-12-31 date: 2024-12-31 date: 2024-03-19 date: 2024-03-19 name: IRCCS Burlo Garofolo class: OTHER briefSummary: A good metabolic control of type 1 diabetes mellitus (T1DM) is crucial to avoid long-term complications associated with the disease. Although recent evidences suggest that a good metabolic control of T1DM is partly independent of management intensity and could be anticipated since onset, factors that influence glycated haemoglobin (HbA1c) patterns remain poorly understood and are likely to be genetic.
This study aims to create a comprehensive database of genetic and phenotypic data in a cohort of children and young adults with T1DM and to evaluate genetic and environmental factors that might predict trajectories in glycemic control conditions: Diabetes Mellitus, Type 1 studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 800 type: ESTIMATED name: Blood and saliva analysis measure: Identification of environmental factors affecting T1DM metabolic control measure: Identification of genetic factors affecting T1DM metabolic control sex: ALL minimumAge: 6 Years maximumAge: 21 Years stdAges: CHILD stdAges: ADULT facility: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" status: RECRUITING city: Trieste zip: 34137 country: Italy name: Antonietta Robino role: CONTACT phone: +39.040.3785.470 email: antonietta.robino@burlo.trieste.it name: Silvia Tommasi role: CONTACT phone: +39.040.3785.863 email: silvia.tommasi@burlo.trieste.it lat: 45.64953 lon: 13.77679 hasResults: False
nctId: NCT06317441 id: NIMCSF137 briefTitle: The Safety and Efficacy of a Probiotic Intervention on SIBO and Related Gastrointestinal Symptoms overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-12 date: 2024-12 date: 2024-03-19 date: 2024-03-19 name: Nimble Science Ltd. class: INDUSTRY name: Lallemand Health Solutions briefSummary: In this study, the goal is to evaluate whether a probiotic formula may reduce symptoms of bloating and abdominal distension in a population suffering from Small Intestinal Bacterial Overgrowth (SIBO) in comparison to a placebo. In addition to the incidence of SIBO, changes to other gastrointestinal symptoms will be assessed. Lastly, the associations between the SIBO status and microbiome from the small and large intestines will be explored using the SIMBA capsule. conditions: Small Intestinal Bacterial Overgrowth studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 105 type: ESTIMATED name: Probiotic measure: Change in bloating/distension severity measure: Median bloating-free days measure: Change in median bloating/distension severity measure: Change in abdominal discomfort/pain measure: Changes in gastrointestinal symptoms measure: Changes in stool frequency and consistency measure: Changes in the quality of life measure: Changes in reflux incidence and severity measure: Changes in the severity of IBS symptoms measure: Recovery rate of the probiotic strain measure: Microbiome changes within small intestine, fecal and saliva samples measure: Investigation how the microbiome and SIBO associate with each other though bacterial population analyses. measure: Change in SIBO positivity rate measure: Exploratory metabolomic analysis measure: Exploratory: Quantifying B. subtilis cell proportions measure: Safety outcomes sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Nimble Science city: Calgary state: Alberta zip: T2L 1Y8 country: Canada name: Gwen Duytschaever role: CONTACT phone: 4037032436 email: Gwen@nimblesci.com name: Christopher N Andrews, MD role: PRINCIPAL_INVESTIGATOR lat: 51.05011 lon: -114.08529 facility: Nimble Science city: Calgary state: Alberta zip: T2L 1Y8 country: Canada name: Marsha Burnes role: CONTACT phone: 4037032436 email: Marsha@nimblesci.com name: Christopher N Andrews, MD role: PRINCIPAL_INVESTIGATOR lat: 51.05011 lon: -114.08529 hasResults: False
nctId: NCT06317428 id: INRCA_001_2024 briefTitle: NT-proBNP Levels During Triple Therapy With Formoterol/Glycopyrrolate/Budesonide in Patients With COPD. acronym: NTproBNP overallStatus: RECRUITING date: 2022-06-28 date: 2025-12-31 date: 2025-12-31 date: 2024-03-19 date: 2024-03-19 name: Istituto Nazionale di Ricovero e Cura per Anziani class: OTHER briefSummary: Observational prospective study to evaluate serum NT-proBNP levels in a population of COPD patients three months after the iniation of triple inhaled formoterol/glycopyrrolate/budesonide therapy. conditions: COPD studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 29 type: ESTIMATED measure: Change in serum NT-pro-BNP levels sex: ALL minimumAge: 50 Years stdAges: ADULT stdAges: OLDER_ADULT facility: INRCA Hospital status: RECRUITING city: Ancona country: Italy name: Francesco Spannella role: CONTACT email: f.spannella@inrca.it name: Riccardo Sarzani, MD role: PRINCIPAL_INVESTIGATOR lat: 43.5942 lon: 13.50337 facility: IRCCS INRCA Hospital status: RECRUITING city: Osimo country: Italy name: Erilda Kamberi, MD role: CONTACT email: e.kamberi@inrca.it name: Yuri Rosati role: PRINCIPAL_INVESTIGATOR lat: 43.48539 lon: 13.48222 hasResults: False
nctId: NCT06317415 id: HuazhongU20240312 briefTitle: Intervention on Non-prescription Antibiotic Use Among the Public overallStatus: COMPLETED date: 2023-04-01 date: 2023-12-31 date: 2024-03-01 date: 2024-03-19 date: 2024-03-20 name: Huazhong University of Science and Technology class: OTHER name: Fuyong People's Hospital, Bao 'an District, Shenzhen City, Guangdong briefSummary: The purpose of this study is to test the effectiveness of health education int led by community health workers for non-prescription antibiotic use among the public. In this two arm cluster randomised trial, In this two-arm cluster randomized controlled trial, 22 communities were randomly allocated in a 1:1 ratio to intervention and control groups. In the intervention group, family doctors will conduct WeChat-based health education on responsible use of antibiotic for the participants. In the control group, only routine public health education will be provided without any involvement in antibiotic use. The primary outcome is the incidence of antibiotic use without prescription in the past month. conditions: Non-Prescription Drug Misuse conditions: Antibiotic Use studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 1550 type: ACTUAL name: WeChat-based health education on antibiotic use name: Regular public health education measure: Rate of non-prescription antibiotic use among the public sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fuyong People's Hospital city: Shenzhen state: Guangdong zip: 518103 country: China lat: 22.54554 lon: 114.0683 hasResults: False
nctId: NCT06317402 id: APHP240133 briefTitle: Epidemiology and Management of Malnutrition of Patients Hospitalized at the Pitié-Salpêtrière Hospital: a One-day Survey Combined With Focus Groups (Mixed Methods) acronym: EPIDENUT_PSL overallStatus: RECRUITING date: 2024-03-09 date: 2025-09-09 date: 2025-09-09 date: 2024-03-19 date: 2024-04-09 name: Assistance Publique - Hôpitaux de Paris class: OTHER briefSummary: According to the literature, malnutrition affects between 30% and 50% of hospitalized patients. The most recent survey on the prevalence of malnutrition in hospitals in France dates back to 2003, and at the Pitié Salpêtrière Hospital to 2015. Malnutrition is a pathological process that can lead to complications for patients and prolong their length of stay.
Main objective: Evaluate the prevalence of malnutrition in adult patients hospitalized on a given day at Pitié-Salpêtrière Hospital (PSL) according to HAS ( High Authority for Health) criteria for 2019 (if age \<70 years) and 2021 (if age ≥ 70 years). conditions: Malnutrition studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 385 type: ESTIMATED name: malnutrition questionary measure: Prevalence of undernutrition diagnosed according to HAS 2019 and 2021 criteria on a given day in hospitalized PSL patients. measure: Compare the prevalence and the severity of undernutrition in hospitalized PSL patients according to the HAS criteria of 2019 (if age <70 years) and 2021 (if age ≥ 70 years) versus those of 2003 (if age <70 years) and 2007 (if age ≥ 70 years). measure: Evaluate the quality of nutritional management for malnourished patients hospitalized at PSL. Using PMSI coding, assess the value of activities associated with undernutrition in undernourished patients hospitalized at PSL. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Service de nutrition, Hôpital Pitié-Salpêtrière status: RECRUITING city: Paris zip: 75013 country: France name: Pauline Faucher, Dr role: CONTACT phone: 01 42 17 57 71 phoneExt: 33 email: pauline.faucher@aphp.fr lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06317389 id: 69HCL23_1237 briefTitle: PACOME (PAtient Cancer Oral MEdication) Cohort of Patients Treated With Oral Anticancer Drugs Benefiting From Oncoral Multidisciplinary Monitoring in Real Life: Predictive Factors and Safety of Treatments acronym: PACOME overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2034-11 date: 2037-01 date: 2024-03-19 date: 2024-03-19 name: Hospices Civils de Lyon class: OTHER briefSummary: With the shift to ambulatory care and the rise of ATCO oral anticancer drugs, a growing number of cancer patients are benefiting from oral treatment in an outpatient setting, which meets their needs and preference over injectable chemotherapy with more autonomy and less time spent in the hospital. However, outside the safe hospital context, the complex pharmacological profile of ATCO exposes patients to iatrogenic drug risks. These medicinal problems or Drug Related Problems DRP linked to ATCO are sources of dosage modifications and lead to sub-therapeutic doses compared to clinical trials and consequently to a reduction, in life actual, dose-intensity and expected response. Furthermore, insufficiently controlled in an ambulatory environment and due to a lack of city-hospital coordination, DRPs lead to an increase in the consumption of care.
Oncoral is the pioneering multidisciplinary city-hospital monitoring of outpatients treated with oral anticancer drugs. Set up in 2014 by the Hospices Civils de Lyon, this educational monitoring is based on a tripartite hospital intervention (oncologist, pharmacist, nurse) and a structured city-hospital link with private health professionals (attending doctor, community pharmacist and freelance nurse). Multidisciplinary interventions are focused on PROs and DRPs and combine an educational approach for the patient based on their needs and potential social vulnerabilities.
This base will make it possible to optimize the treatment of patients at the individual and population level and to generate evidence in addition to clinical trials, which are expected by health professionals and decision-makers. With patient data from the secure Oncoral pathway, PACOME brings together the three major and inseparable assets of real-life databases: quality, completeness and meaning of the data. It constitutes a basis for essential academic and private collaborations for studies on data and comparative observational or interventional studies, which will contribute to the animation of the new ecosystem of real-life health data in oncology. conditions: Cancer conditions: Oncology conditions: Oncoral Program studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 3000 type: ESTIMATED name: Questionnaires measure: Relative-Dose-Intensity (RDI) in real life with a prospective follow-up of 6 months within the limit of the duration of treatment with oral anticancer drugs by setting up a data platform for adult patients taking oral anticancer drugs sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Groupement Hospitalier Sud - Unité de Pharmacie Clinique Oncologique city: Pierre-Bénite zip: 69495 country: France name: Catherine RIOUFOL, Pr role: CONTACT name: Florence RANCHON, MCU-PH role: SUB_INVESTIGATOR name: Anne-Gaëlle CAFFIN, Dr role: SUB_INVESTIGATOR name: Marie-Anne CERFON, PH role: SUB_INVESTIGATOR lat: 45.7009 lon: 4.82511 hasResults: False
nctId: NCT06317376 id: REC/014131 Maria Haseen briefTitle: Group-based Cardiac Rehabilitation on Patients With Coronary Artery Bypass Graft Surgery overallStatus: COMPLETED date: 2023-09-01 date: 2024-01-15 date: 2024-01-18 date: 2024-03-19 date: 2024-03-19 name: Riphah International University class: OTHER briefSummary: 1. To determine the effect of Moderate intensity continuous training on Pulmonary function of CABG patients.
2. To determine the effect of MICT on aerobic Capacity of CABG patients. conditions: Post-cardiac Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 54 type: ACTUAL name: MICT with Aerobic exercise on treadmill name: standard hospital protocol measure: Borg rating of perceived exertion scale measure: 6min walk test sex: ALL minimumAge: 40 Years maximumAge: 60 Years stdAges: ADULT facility: RMI city: Peshawar country: Pakistan lat: 34.008 lon: 71.57849 hasResults: False