hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06372106 id: MA_PM_Mountain_2022_11496 briefTitle: Project Mountain - Comparing SpO2 and SaO2 for Accuracy overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2024-12 date: 2024-04-17 date: 2024-04-17 name: Philips Clinical & Medical Affairs Global class: INDUSTRY briefSummary: The main goal of this study is to look at the performance of the neonatal, infant, and pediatric Philips SpO2 sensors with the Philips FAST Pulse Oximetry technology. Oxygen saturation measurements (SpO2) will be obtained via pulse oximetry and invasive arterial oxygen measurements (SaO2) will be obtained via arterial blood samples as part of your clinical care and assessed by co-oximetry. The study will aim to enroll a diverse population to help us understand the impact of skin pigmentation. conditions: SpO2 conditions: Nasal Alar Collapse, Bilateral conditions: Oxygen conditions: Measurement studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: OTHER count: 560 type: ESTIMATED name: SaO2 Sampling measure: To observed accuracy expressed in ARMS of SpO2 measurements obtained from neonatal, infant, and pediatric sensors with the Philips FAST Pulse Oximetry technology within the range of 70-100% in comparison to the SaO2 as ground truth. measure: Secondary Endpoint -Non-disparate bias with consideration to skin pigmentation for each neonatal, infant, and pediatric SpO2 sensor under test with the Philips FAST Pulse Oximetry technology. measure: Secondary Endpoint- Proportion of paired SaO2 and SpO2 readings in which occult hypoxemia (i.e., SaO2 <88% with SpO2 ≥92%) is identified among patients within the broad categories of light, medium, and dark pigmentation. sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06372093 id: PMH 2/11AII briefTitle: Evaluation of Bilirubin Measurements in Newborns From Smartphone Digital Images in a Population in Botswana overallStatus: COMPLETED date: 2023-03-16 date: 2024-02-26 date: 2024-02-26 date: 2024-04-17 date: 2024-04-17 name: Picterus AS class: INDUSTRY name: University of Copenhagen name: University of Botswana briefSummary: The general objective of this study is to evaluate the accuracy of a novel smartphone application for jaundice screening (Picterus Jaundice Pro) in a population with high melanin content in the skin.
ii. To determine the accuracy of Picterus Jaundice Pro in newborns with high melanin content in the skin. conditions: Jaundice, Neonatal studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 172 type: ACTUAL name: Picterus Jaundice Pro measure: Enable high qualitative estimation of bilirubin levels in the blood of newborns in a population in Botswana using Picterus JP. measure: Correlation of bilirubin levels obtained by Picterus JP with Tsb and TcB measure: Sensitivity and specificity of Picterus JP to detect jaundice in newborns with high melanin content in the skin sex: ALL minimumAge: 1 Day maximumAge: 14 Days stdAges: CHILD facility: Princess Marina Hospital city: Gaborone country: Botswana lat: -24.65451 lon: 25.90859 hasResults: False
nctId: NCT06372080 id: 19/SPS/054 briefTitle: Resistance Training and Hydrolyzed Collagen Supplementation in Healthy Young Adults overallStatus: COMPLETED date: 2020-01-06 date: 2021-09-29 date: 2023-03-31 date: 2024-04-17 date: 2024-04-17 name: Liverpool John Moores University class: OTHER briefSummary: The goal of this clinical trial is to investigate the effects of resistance training with hydrolyzed collagen ingestion on changes in muscle and tendon adaptation in healthy young men and women.
Researchers will compare collagen and placebo groups to see if hydrolyzed collagen ingestion with resistance exercise would have beneficial effects on changes in muscle and tendon more than resistance training alone. Therefore, using isokinetic dynamometer and ultrasonography, maximal leg strength, morphological, mechanical, and material properties of the patellar tendon and vastus lateralis muscle size and architecture will be assessed. conditions: Healthy Participants conditions: Nutrition conditions: Exercise Training studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study design is a single-blind (participants were unaware of their group allocation), randomized controlled trial. primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 23 type: ACTUAL name: Resistance training with hydrolyzed collagen ingestion in healthy young men name: Resistance training with hydrolyzed collagen ingestion in healthy young women measure: Maximal knee extensor (quadriceps) muscle strength measure: Maximal knee flexor (hamstring) muscle strength measure: Patellar tendon cross-sectional area measure: Patellar tendon stiffness measure: Vastus lateralis (VL) muscle size measure: Vastus lateralis (VL) muscle fascicle length measure: Vastus lateralis (VL) muscle fascicle pennation angle sex: ALL minimumAge: 18 Years maximumAge: 39 Years stdAges: ADULT facility: Research Institute for Sport and Exercise Sciences city: Liverpool state: Merseyside zip: L3 3AF country: United Kingdom lat: 53.41058 lon: -2.97794 hasResults: False
nctId: NCT06372067 id: 17378 briefTitle: IM Screw vs. K-wire Fixation of Proximal/Middle Phalanx Fractures acronym: HANDFIX overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-12-31 date: 2026-03-01 date: 2024-04-17 date: 2024-04-17 name: McMaster University class: OTHER briefSummary: When people break their fingers, sometimes surgery is needed to align the bones to heal them properly. There are different ways to fix broken bones in hands, such as plates, pins, or screws. Each method has pros and cons; fixing a broken bone with plates is usually a larger surgery with more cutting but holds the bones very securely. Pins require little to no cutting but the patient needs to immobilize their hand for a few weeks afterwards. Screws are a newer method of fixing broken fingers that requires little cutting and also holds the bones securely. The goal of this study is to compare the effectiveness of using pins versus screws in surgery for broken fingers. The investigators are studying whether using screws leads to better hand function, patient satisfaction, and quicker return to work. conditions: Hand; Fracture, Phalanx studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized, open-label, pilot randomized controlled trial primaryPurpose: TREATMENT masking: SINGLE maskingDescription: By nature of the interventions in this study, blinding will not be possible for the surgeon or the patient post-operatively. whoMasked: OUTCOMES_ASSESSOR count: 34 type: ESTIMATED name: Intramedullary screw name: Kirschner wire measure: Percentage of Patient Eligibility - Study Feasibility measure: Recruitment rate - Study Feasibility measure: Crossover rate - Study Feasibility measure: Compliance with intervention rate - Study Feasibility measure: Patient retention rate - Study Feasibility measure: Disability of the Arm, Shoulder, and Hand measure: Range of motion measure: Grip strength measure: Return to work measure: Complications/adverse events measure: Postoperative pain (visual analogue scale) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06372054 id: TORNADO briefTitle: TORNADO-Omics Techniques and Neural Networks for the Development of Predictive Risk Models overallStatus: RECRUITING date: 2024-02-05 date: 2025-02-05 date: 2027-02-05 date: 2024-04-17 date: 2024-04-17 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico class: OTHER name: University of Milan name: Italian Air Force name: A-Tono name: Ministry of Defense, Italy briefSummary: The goal of this observational study is to define a personalized risk model in the super healthy and homogeneous population of Italian Air Force high-performance pilots. This peculiar cohort conducts dynamic activities in an extreme environment, compared to a population of military people not involved in flight activity. The study integrates the analyses of biological samples (urine, blood, and saliva), clinical records, and occupational data collected at different time points and analyzed by omic-based approaches supported by Artificial Intelligence. Data resulting from the study will clarify many etiopathological mechanisms of diseases, allowing the creation of a model of analyses that can be extended to the civilian population and patient cohorts for the potentiation of precision and preventive medicine. conditions: Oxidative Injury conditions: Stress Physiological conditions: Discogenic Pain conditions: Cardiovascular Risk Factor conditions: Space Maintenance conditions: Epigenetic Changes conditions: LONGEVITY 1 conditions: Neuroplasticity conditions: NGS studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED name: Biological sample collection measure: Assessment of flight-related exposure data and molecular modifications measure: Assessment of General Health measure: Assessment of Sleep Quality measure: Assessment of eating habits measure: Creation of reliable AI and disease-based models for personalized medicine sex: ALL minimumAge: 26 Years maximumAge: 38 Years stdAges: ADULT facility: CeMATA - Joint Center for Aerospace Medicine and Advanced Therapy status: RECRUITING city: Milan zip: 20139 country: Italy name: Stefania E Navone, PhD role: CONTACT phone: 0256660100 phoneExt: +39 email: stefania.navone@policlinico.mi.it name: Giovanni Marfia, MD, PhD role: PRINCIPAL_INVESTIGATOR name: Laura Guarnaccia, PhD role: SUB_INVESTIGATOR name: Stefania E Navone, PhD role: SUB_INVESTIGATOR name: Monica R Miozzo, PhD role: SUB_INVESTIGATOR name: Orazio Granato, PhD role: SUB_INVESTIGATOR name: Silvana Pileggi, PhD role: SUB_INVESTIGATOR name: Luisella Vigna, MD, PhD role: SUB_INVESTIGATOR name: Matteo Bonzini, MD, PhD role: SUB_INVESTIGATOR name: Laura Fontana, PhD role: SUB_INVESTIGATOR name: Laura Begani, MSc role: SUB_INVESTIGATOR lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06372015 id: RC2023-24 briefTitle: Changes in the Lipidomic, Immunological and miRNA Profile in Patients Undergoing a Dietary Program or Bariatric Surgery overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-06-01 date: 2026-06-01 date: 2024-04-17 date: 2024-04-17 name: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis class: OTHER name: Notarnicola Maria name: Cozzolongo Raffaele name: Shahini Endrit name: De Pergola Giovanni name: Lippolis Giuseppe briefSummary: Obesity is a chronic disease characterized phenotypically by an increase in body weight (BMI\>30 kg/m2) and by a series of associated pathologies, such as hypertension, diabetes, hepatic steatosis.
The choice of the surgeon, assisted by the multidisciplinary team, is binding in the choice of the type of operation to which the patient will be subjected. conditions: Obesity conditions: Liver Disease Parenchymal studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: OTHER count: 60 type: ESTIMATED name: Nutritional Approach name: Surgery Approach measure: Variation of lipidomic parameters measure: The effect of intervention on routine blood chemistry parameters, relating to NAFLD and fibrosis measure: Variation in the microRNA profile sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS "Saverio de Bellis" city: Castellana Grotte state: Bari zip: 70013 country: Italy name: Rossella Donghia, Biologyst role: CONTACT phone: 0804994652 email: rossella.donghia@irccsdebellis.it lat: 40.88643 lon: 17.16549 hasResults: False
nctId: NCT06372002 id: 05/23 briefTitle: Effectiveness and Cost-Effectiveness of Cognitive Stimulation Therapy - Spain (CST-ES) in People Living With Dementia overallStatus: ACTIVE_NOT_RECRUITING date: 2023-10-16 date: 2024-07-31 date: 2024-07-31 date: 2024-04-17 date: 2024-04-17 name: Instituto de Mayores y Servicios Sociales (IMSERSO) class: OTHER_GOV name: University of Castilla-La Mancha name: Confederación Española de Alzheimer (CEAFA) briefSummary: This study aims to evaluate the effectiveness and cost-effectiveness of CST-ES, the Spanish adaptation of Cognitive Stimulation Therapy (CST), to improve cognition and quality of life in people with mild to moderate dementia.
The evaluation will be conducted as a pragmatic multicenter randomized controlled clinical trial. Participants will be randomized to receive 7 weeks of CST-ES followed by 24 weeks of maintenance CST-ES (intervention group) or to continue their usual treatment (control group). conditions: Dementia conditions: Neurocognitive Disorders conditions: Mild Cognitive Impairment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A pragmatic, multicenter, randomized, controlled clinical trial is proposed to compare treatment with CST-ES followed by maintenance treatment with CST-ES with treatment as usual:
* Second Phase: After the first phase is completed, participants assigned to the intervention group will receive one session of maintenance CST-ES per week for 24 weeks besides continuing their usual treatment, whereas participants in the control group will continue their usual treatment during this second phase. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: The technician in charge of the evaluation of those participating in the study must be blinded throughout the CST intervention, i.e., he/she will not know whether the users being evaluated belong to the intervention or the control group.
nctId: NCT06371989 id: 19/160 briefTitle: Vacuum Assisted Biopsy and Surgery Correlation in HER2 and TN Breast Cancer Subtypes MRI Responders After Neoadjuvant Therapy: BISUCO TRIAL acronym: BISUCO overallStatus: COMPLETED date: 2019-03-11 date: 2021-03-20 date: 2022-12-20 date: 2024-04-17 date: 2024-04-17 name: Hospital Universitario 12 de Octubre class: OTHER briefSummary: BACKGROUND AND CURRENT STATUS:
Advancements in neoadjuvant systemic treatments (NST) for HER2 positive and triple-negative (TN) breast cancer (BC) subtypes have led to high rates of pathologic complete response (pCR), raising questions about the necessity of subsequent surgery, especially for those undergoing adjuvant radiotherapy. While Magnetic Resonance Imaging (MRI) remains the most effective imaging technique for assessing neoadjuvant treatment response, surgery is still required to confirm pCR in cases of almost complete or complete MRI response (iCR). To safely avoid surgery in these BC "exceptional responders," a technique with high negative predictive value is imperative.
A prospective study was conducted at "Hospital Universitario 12 de Octubre de Madrid" from June 25, 2018, to October 25, 2029. Twenty-five patients with HER2-positive or TN operable invasive ductal carcinoma (IDC) BC subtype, at stages cT1-3/N0-2 undergoing primary NST and showing complete or almost complete response on post NST-MRI, were enrolled. Ultrasound or stereotactic-guided vacuum-assisted biopsy (VAB) of the previous clip and tumor bed area was performed before surgery. VAB pathological results were compared with surgical pathological results to evaluate the diagnostic efficacy of predicting pCR with VAB after NST. Pathological representativeness of the VAB sample was ensured. pCR was defined as the absence of invasive ductal carcinoma and in situ ductal carcinoma. conditions: Breast Cancer conditions: Breast Biopsy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single Group Assignment primaryPurpose: DIAGNOSTIC masking: NONE count: 25 type: ACTUAL name: Image guided vacuum assisted biopsy measure: The negative Predictive Value (NPV), Positive predictive value, specificity and sensibility of the VAB compared to Standard Surgery with Pathologic Evaluation sex: FEMALE minimumAge: 18 Years maximumAge: 95 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sara Jimenez Arranz city: Madrid zip: 28020 country: Spain lat: 40.4165 lon: -3.70256 hasResults: False
nctId: NCT06371976 id: APH240230 briefTitle: Evaluation of the HPA Axis in Patients With Vasoplegic Syndrome After Cardiac Surgery acronym: VASOCORT overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-04-01 date: 2025-04-01 date: 2024-04-17 date: 2024-04-17 name: Assistance Publique - Hôpitaux de Paris class: OTHER briefSummary: Vasoplegic syndrome after cardiac surgery is common and is associated with increased morbidity and mortality. It is characterized by early and prolonged arterial hypotension, with preserved cardiac output and low systemic vascular resistance. Vasoplegic syndrome therefore shares pathophysiological features with septic shock. There are no data in the literature on the function of the hypothalamic-pituitary-adrenal (HPA) axis during vasoplegic syndrome after cardiac surgery. In situations of acute stress and systemic inflammation, relative adrenal insufficiency has been reported in the most severe patients, particularly those in septic shock. The term ""CIRCI"" (Critical Illness-Related Corticosteroid Insufficiency) is currently defined as an increase in total plasma cortisol of less than 9 µg/dl after stimulation with 250 µg tetracosactide (synthetic ACTH), or a basal total plasma cortisol level of less than 10 µg/dl. However, recent studies have called into question the usefulness of the cosyntropin stimulation test for exploring the HPA axis in intensive care patients.
The aim of this study is to evaluate, on an exploratory basis, the impact of the presence of a post-cardiac surgery vasoplegic syndrome on adrenal function by steroidome mapping (LC-MS/MS). conditions: Vasoplegic Syndrome in Adult Cardiac Surgery studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED name: Blood sampling name: Vital status measure: Impact of post-cardiac surgery vasoplegic syndrome on corticotropic function. measure: Evaluate corticotropic function by measuring steroid metabolites according to the presence or absence of ""CIRCI"" in patients with vasoplegic syndrome. measure: Evaluate the association between CIRCI and the severity of vasoplegic syndrome after cardiac surgery. measure: To assess the association between ""CIRCI"" and the duration of post-cardiac surgery vasoplegic syndrome. measure: To assess the association between ""CIRCI"" and length of stay in intensive care. measure: Evaluate the association between ""CIRCI"" and in-hospital mortality sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pitié-Salpêtrière city: Paris state: Ile-de-France zip: 75013 country: France name: Adrien Bouglé, MD, PhD role: CONTACT phone: 00 33 42 16 29 91 email: adrien.bougle@aphp.fr name: Jérémie Guillemin, MD role: CONTACT phone: 00 33 84 82 82 58 email: jeremie.guillemin@aphp.fr lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06371963 id: LinnaeusU REDs briefTitle: Relative Energy Deficiency in Sports (REDs) in Swedish Athletes acronym: REDs-Sweden overallStatus: RECRUITING date: 2022-05-10 date: 2024-05 date: 2026-12 date: 2024-04-17 date: 2024-04-18 name: Linnaeus University class: OTHER name: Swedish Olympic Committee name: Swedish Research Council for Sport Science name: World Anti-Doping Agency briefSummary: Background: Relative Energy Deficiency in Sport (REDs) describes impairment of health and performance due to problematic (long-term/severe) low energy availability (LEA), with or without eating disorders. LEA is frequently reported in sports with high training volumes, especially in leanness demanding sports, and 20% of female and 9% of male Norwegian national team athletes have been reported to have eating disorders. Potential trigger factors are e.g., dieting, injuries, coaching behavior, and subculture aspects e.g., focus on low body weight. The main questions that will be addressed are: 1. What is the prevalence of eating disorders and REDs among Swedish elite athletes and controls? 2. What is the impact of problematic LEA on health and performance aspects in both male and female athletes? Methods: National team athletes and gender and matched controls will be invited to an anonymous on-line survey. Elite athletes who agree to participate, will be invited to assessment of eating disorders, nutritional and physiological status (e.g., metabolic and endocrine markers, bone health, microbiota, dietary intake, energy availability, and performance). conditions: RED S conditions: Eating Disorders studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 500 type: ESTIMATED measure: Self-reported eating disorders measure: Eating disorders measure: Self-reported reproductive function in females not using hormonal contraceptives measure: Reproductive function in females not using hormonal contraceptives measure: Self-reported reproductive function in males measure: Reproductive function in males measure: Gastrointestinal function measure: Injury measure: Self- reported symptoms of depression measure: Compulsive exercise measure: The motivation for behavioral changes measure: Psychological flexibility measure: Changes in immune markers from pre to post exercise measure: Microbiota measure: Dietary intake measure: Maximal aerobic capacity measure: Explosive lower body power measure: Whole body strength measure: Muscular power measure: Resting Metabolic Rate measure: Body composition measure: Body weight measure: Body height measure: Glucose levels sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Linnaeus University status: RECRUITING city: Kalmar state: Småland country: Sweden name: Anna Melin, PhD role: CONTACT phone: 0732629714 email: anna.melin@lnu.se lat: 56.66157 lon: 16.36163 hasResults: False
nctId: NCT06371950 id: 123608 briefTitle: Gut Microbiome in Orthopaedics acronym: GUMBO overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-04-01 date: 2027-01-01 date: 2024-04-17 date: 2024-04-17 name: Lawson Health Research Institute class: OTHER briefSummary: Patients having knee replacement surgery regularly experience joint pain and compromised bone quality leading to implant loosening and periprosthetic fractures. The role of the gut microbiome, which is the collection of bacteria and other microbes within the human gastrointestinal tract, is just beginning to be recognized, including its potential effects on pain, infection, and loosening after total joint replacement. Antibiotics are regularly used in orthopaedic surgery to reduce the risk of infection, but they also harm gut microbiota and reduce their potentially beneficial effects. Probiotics may have a role to play in enhancing bone quality and decreasing synovial inflammation after joint replacement surgery, and this study will explore the potential relationship of probiotic use with implant migration, bone density, and patient outcomes.