nctId: NCT06271837 id: D781AC00001 briefTitle: A Study of T-DXd in Patients With Selected HER2-overexpressing Tumors overallStatus: RECRUITING date: 2024-02-18 date: 2025-10-30 date: 2026-04-17 date: 2024-02-22 date: 2024-04-23 name: AstraZeneca class: INDUSTRY name: Daiichi Sankyo Co., Ltd. briefSummary: This is an open-label, multicenter, Phase II study to evaluate the efficacy and safety of trastuzumab deruxtecan for the treatment in locally advanced, unresectable, or metastatic patients with selected HER2 overexpressingsolid tumors which are not eligible for curative therapy. conditions: Advanced Solid Tumors (Excluding Gastric Cancer and Breast Cancer) studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE maskingDescription: This study is Open-Label Study. count: 50 type: ESTIMATED name: Trastuzumab deruxtecan measure: Confirmed Objective Response Rate (ORR) by Independent Central Review (ICR) measure: Confirmed Objective Response Rate (ORR) by investigator assessment measure: Duration of Response (DoR) by Independent Central Review (ICR) measure: Duration of Response (DoR) by investigator assessment measure: Disease control rate (DCR) by Independent Central Review (ICR) measure: Disease control rate (DCR) by investigator assessment measure: Confirmed best objective response (BOR) by Independent Central Review (ICR) measure: Confirmed best objective response (BOR) by investigator assessment measure: Progression-free survival (PFS) by Independent Central Review (ICR) measure: Progression-free survival (PFS) by investigator assessment measure: Overall survival (OS) measure: Occurrence of adverse events (AEs) and serious adverse events (SAEs) measure: Pharmacokinetics (PK) of T-DXd measure: Immunogenicity of T-DXd sex: ALL minimumAge: 18 Years maximumAge: 130 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Research Site status: NOT_YET_RECRUITING city: Beijing zip: 100142 country: China lat: 39.9075 lon: 116.39723 facility: Research Site status: NOT_YET_RECRUITING city: Changchun zip: 130021 country: China lat: 43.88 lon: 125.32278 facility: Research Site status: NOT_YET_RECRUITING city: Changsha zip: 410013 country: China lat: 28.19874 lon: 112.97087 facility: Research Site status: NOT_YET_RECRUITING city: Changzhou zip: 213004 country: China lat: 31.77359 lon: 119.95401 facility: Research Site status: NOT_YET_RECRUITING city: Chengdu zip: 610041 country: China lat: 30.66667 lon: 104.06667 facility: Research Site status: NOT_YET_RECRUITING city: Chongqing zip: 400030 country: China lat: 29.56278 lon: 106.55278 facility: Research Site status: NOT_YET_RECRUITING city: Dongyang zip: 322100 country: China lat: 29.26778 lon: 120.22528 facility: Research Site status: NOT_YET_RECRUITING city: Guangzhou zip: 510145 country: China lat: 23.11667 lon: 113.25 facility: Research Site status: NOT_YET_RECRUITING city: Guangzhou zip: 510630 country: China lat: 23.11667 lon: 113.25 facility: Research Site status: WITHDRAWN city: Haikou zip: 570311 country: China lat: 20.04583 lon: 110.34167 facility: Research Site status: NOT_YET_RECRUITING city: Hangzhou zip: 310022 country: China lat: 30.29365 lon: 120.16142 facility: Research Site status: RECRUITING city: Harbin zip: 150081 country: China lat: 45.75 lon: 126.65 facility: Research Site status: NOT_YET_RECRUITING city: Hefei zip: 230031 country: China lat: 31.86389 lon: 117.28083 facility: Research Site status: NOT_YET_RECRUITING city: Kunming zip: 650118 country: China lat: 25.03889 lon: 102.71833 facility: Research Site status: NOT_YET_RECRUITING city: Lishui zip: 323000 country: China lat: 28.46042 lon: 119.91029 facility: Research Site status: NOT_YET_RECRUITING city: Nanchang zip: 330029 country: China lat: 28.68396 lon: 115.85306 facility: Research Site status: NOT_YET_RECRUITING city: Shanghai zip: 200011 country: China lat: 31.22222 lon: 121.45806 facility: Research Site status: NOT_YET_RECRUITING city: Shanghai zip: 200032 country: China lat: 31.22222 lon: 121.45806 facility: Research Site status: NOT_YET_RECRUITING city: Shenyang zip: 110016 country: China lat: 41.79222 lon: 123.43278 facility: Research Site status: NOT_YET_RECRUITING city: Xuzhou zip: 221009 country: China lat: 34.18045 lon: 117.15707 facility: Research Site status: NOT_YET_RECRUITING city: Yinchuan zip: 750004 country: China lat: 38.46806 lon: 106.27306 facility: Research Site status: NOT_YET_RECRUITING city: Zhengzhou zip: 450008 country: China lat: 34.75778 lon: 113.64861 hasResults: False