hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06373510 id: ELCAV briefTitle: Longitudinal Evaluation of Antibody Kinetics of Vaccinated Patients With Non-mandatory Vaccine Following Administration of a Non-public Marketed Vaccine in the General Population, Real-life Study acronym: ELCAV overallStatus: NOT_YET_RECRUITING date: 2024-06-20 date: 2027-04-03 date: 2027-04-03 date: 2024-04-18 date: 2024-04-18 name: CerbaXpert class: OTHER briefSummary: The study would make it possible to document more explicitly the evolution of antibody titers at following a non-public vaccination over a large post-vaccination period in the French population .
Analysis of real-life data would enhance knowledge of vaccine response kinetics It would be useful to identify possible early declines requiring doses Similarly, by analyzing antibody kinetics by age, sex, and vaccination status, the would be possible to determine whether there are differences in the immune response between these different sub-groups. In addition, it would provide additional information to assess the real impact of these non-public vaccines in public health and guide vaccine policies. conditions: Vaccination Reaction studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 10000 type: ESTIMATED name: Blood collection measure: Quantification of specific serum antibodies (IgM, IgG) at different times before and/or after vaccination by a reference technique such as ELISA. sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06373497 id: IIT2023-08-ATKINS-ATHERO-RT briefTitle: Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2026-04 date: 2026-04 date: 2024-04-18 date: 2024-04-18 name: Katelyn Atkins class: OTHER briefSummary: The prospective single-arm pilot study, ATHERO-RT: Real-Time Atherosclerosis Activity after Thoracic Radiotherapy using Sodium Fluoride Positron Emission Tomography, will aim to:
Eligible patients will be adults (≥18 years old) with Stage II-III or oligo-metastatic stage IV malignancy (any histology) at high risk for RT-associated cardiac toxicity (defined as receiving ≥30 Gy (Gray) RT where the heart is in the treatment field54). The study will enroll a total of 10 subjects, recruited from Cedars-Sinai Medical Center. The primary endpoint will be successful completion of 18F-NaF PET imaging at the baseline and 6-month post-RT time points. Blood will be collected at baseline, end of RT, and 6-months post-RT. conditions: Oligometastatic Disease studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: 18-F-NaF Cardiac PET/MRI and name: CT Angiogram measure: Feasibility of using F-NaF PET/MRI imaging measure: To measure changes in standard uptake value (SUV) measure: To measure changes in coronary microcalcification activity (CMA) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cedars Sinai Medical Center city: Los Angeles state: California zip: 90048 country: United States name: Clinical Trial Recruitment Navigator role: CONTACT phone: 310-423-2133 email: cancer.trial.info@cshs.org name: Katelyn Atkins, MD, PhD role: PRINCIPAL_INVESTIGATOR name: Alan Kwan, MD, MS role: SUB_INVESTIGATOR name: Louise Thomson, MD role: SUB_INVESTIGATOR name: Andriana Nikolova, MD, PhD role: SUB_INVESTIGATOR name: Anja Karlstaedt, MD, Phd role: SUB_INVESTIGATOR name: Eric Vail, MD role: SUB_INVESTIGATOR name: Celeste Eno, PhD role: SUB_INVESTIGATOR name: Stephen Shiao, MD, PhD role: SUB_INVESTIGATOR name: Elizabeth McKenzie, PhD role: SUB_INVESTIGATOR lat: 34.05223 lon: -118.24368 hasResults: False
nctId: NCT06373484 id: 018-2022 briefTitle: Matching Assessment and Treatment for Children With Disruptive Behaviour and Their Parents acronym: MATCH-DB overallStatus: RECRUITING date: 2022-10-01 date: 2026-09 date: 2027-09 date: 2024-04-18 date: 2024-04-18 name: Centre for Addiction and Mental Health class: OTHER briefSummary: This study will develop and test whether personalized profiles of children with Disruptive Behaviour Disorder (DBD) and their parents based on important psychological, emotional, and neuropsychological indicators predict their response to child cognitive behavioral treatment and Behavioral Parent Training. conditions: Disruptive Behavior Disorder conditions: Emotional Disorder conditions: Behavioural Disorder conditions: Attention Deficit Hyperactivity Disorder conditions: Conduct Disorder conditions: Oppositional Defiant Disorder studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 200 type: ESTIMATED name: Behavioral Parent Training measure: Changes in parenting skills between baseline, post-treatment, and follow-up (6 months - 1 year) measure: Changes in parenting competencies between baseline, post-treatment, and follow-up (6 months - 1 year) measure: Changes in child emotional and behavioral problems between baseline, post-treatment, and follow-up (6 months - 1 year) sex: ALL minimumAge: 6 Years maximumAge: 12 Years stdAges: CHILD facility: Centre for Addiction and Mental Health status: RECRUITING city: Toronto state: Ontario zip: M6J 1H4 country: Canada name: Brendan F. Andrade, PhD role: CONTACT phone: 416-535-8501 phoneExt: 33642 email: brendan.andrade@camh.ca lat: 43.70011 lon: -79.4163 hasResults: False
nctId: NCT06373471 id: S-20230101 briefTitle: Improving Quality of Life in Older Patients With Frailty and Hematological Cancer Through Geriatric Assessment acronym: IMPROVE overallStatus: RECRUITING date: 2024-04-02 date: 2026-03-31 date: 2026-09-30 date: 2024-04-18 date: 2024-04-18 name: Odense University Hospital class: OTHER name: Velux Fonden name: Danish Cancer Research Foundation name: The Dagmar Marshall Foundation briefSummary: The Improve study is a randomized controlled trial investigating the efficacy of adding comprehensive geriatric assessment and treatment to standard of care compared with standard of care in older, frail patients with hematological cancer. The investigators aim to recruit 152 study participants who will be randomized 1:1 to intervention- or control group. Study participants in the intervention group will receive the intervention comprehensive geriatric assessment and treatment integrated in the cancer treatment. Study participants in the control group will receive cancer treatment and evaluation of comorbidity and frailty as is usual standard at Department of Hematology. Primary endpoint is elderly functional Index at 12 weeks. conditions: Hematologic Malignancy conditions: Treatment Adherence conditions: Treatment Complication conditions: Frailty conditions: Quality of Life studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 152 type: ESTIMATED name: Comprehensive geriatric assessment (CGA) and treatment measure: Elderly functional Index measure: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). measure: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Elderly14 (EORTC QLQ-Eld14). measure: Handgrip strength measure: 30-second chair stand test measure: Treatment toxicity measure: Adherence to hematological cancer treatment measure: Polypharmacy yes/no measure: Unplanned hospital admissions measure: Overall and cancer specific survival sex: ALL minimumAge: 70 Years stdAges: OLDER_ADULT facility: Odense University Hospital status: RECRUITING city: Odense C zip: 5000 country: Denmark name: Nina Andersen, M.D. role: CONTACT phone: +4540437488 email: nina.andersen@rsyd.dk lat: 55.39594 lon: 10.38831 hasResults: False
nctId: NCT06373458 id: STUDY-23-01508 briefTitle: Ritlecitinib in Patients With Keloids or Those Undergoing Keloidectomy overallStatus: RECRUITING date: 2024-04-15 date: 2026-03 date: 2026-05 date: 2024-04-18 date: 2024-04-18 name: Icahn School of Medicine at Mount Sinai class: OTHER name: Pfizer briefSummary: Keloids are common, benign cutaneous overgrowths that manifest clinically as raised, hypertrophic, often hyperpigmented lesions which are formed in response to dermal injury or idiopathic stimuli. Although keloids are a common disease, it's exact incidence and prevalence is not known. Despite the debilitating nature of keloids, current treatment modalities are limited in efficacy; there is no universally effective therapy available to patients. The research team hypothesize that ritlecitinib as a JAK3/TEC inhibitor will be able to reverse both the systemic and local keloid disease process by re-establishing immune homeostasis. conditions: Keloid studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Ritlecitinib measure: Recurrence Rate measure: Change in Detroid Keloid Scale Score measure: Change in Peak keloid tension measure: Change in Detroid Keloid Scale Score (DKS) measure: Change in Pain Numerical Rating Scale (Pain-NRS) measure: Change in Itch-NRS measure: Change in PGIC (Patient Global Impression of Change) measure: Change in DLQI (Dermatology Life Quality Index) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Icahn School of Medicine at Mount Sinai status: RECRUITING city: New York state: New York zip: 10029 country: United States name: Giselle Singer role: CONTACT phone: 212-241-3288 email: giselle.singer@mssm.edu name: Sharlene Martin role: CONTACT phone: 212-241-3288 name: Emma Guttman role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06373445 id: 36264PR596 briefTitle: Interventional Neuromodulation in Fibromyalgia overallStatus: RECRUITING date: 2022-11-01 date: 2023-09-01 date: 2024-04-15 date: 2024-04-18 date: 2024-04-18 name: Tanta University class: OTHER briefSummary: This study was conducted on 40 eligible fibromyalgia patients with sleep disorders. They were randomized to have 20 sessions of active or sham rTMS (1 Hz, 120% of resting motor threshold with total 1200 pules /session) over the right dorsolateral prefrontal area (DLPFC) for 5 sessions/week for 4 weeks. All participants were subjected to baseline evaluation with Fibromyalgia Impact Questionnaire, polysomnography, sleep quality and sleep characteristics assessment using the Pittsburgh Sleep Quality Index and The Medical Outcomes Study Sleep Scale respectively.FM patients were reevaluated at 1, 3 months after the end of rTMS sessions. conditions: Neuromodulation and Sleep Disorders studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL interventionModelDescription: participants randomly allocated to either no, one, some or all interventions simultaneously primaryPurpose: TREATMENT masking: SINGLE whoMasked: CARE_PROVIDER count: 60 type: ESTIMATED name: repetitive transcranial magnetic stimulation active stimulation name: repetitive transcranial magnetic stimulation sham stimulation measure: Pittsburgh Sleep Quality Index (PSQI) measure: The Medical Outcomes Study Sleep Scale (MOS ) measure: polysomnography measure: Pittsburgh Sleep Quality Index (PSQI) measure: The Medical Outcomes Study Sleep Scale (MOS) measure: polysomnography sex: ALL minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT facility: Faculty of medicine status: RECRUITING city: Tanta state: ElGharbia zip: 6620010 country: Egypt name: Marwa Y Badr role: CONTACT phone: 01003639125 phoneExt: Tanta email: drmoroneuro@yahoo.com lat: 30.78847 lon: 31.00192 hasResults: False
nctId: NCT06373432 id: STUDY-22-01607 briefTitle: Frequency of Glucose Monitoring in Labor overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-11-26 date: 2024-11-26 date: 2024-04-18 date: 2024-04-18 name: Icahn School of Medicine at Mount Sinai class: OTHER briefSummary: The aim of this study is to assess rates of neonatal hypoglycemia with differing intrapartum glucose protocols. Currently at this time there is no guidance from professional medical organizations about when and how frequent to assess maternal glucose levels intrapartum. Several institutions have no protocols in place. The study will be a randomized controlled trial placing patients with Gestational Diabetes Mellitus (GDM) in "frequent" vs "infrequent" glucose monitoring intrapartum and assessing neonatal glucose levels at birth. conditions: Neonatal Hypoglycemia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 160 type: ESTIMATED name: Fingerstick measure: Neonatal Hypoglycemia sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mount Sinai West Hospital city: New York state: New York zip: 10019 country: United States lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06373419 id: RP-1007 briefTitle: TFL vs MOSES Holmium Laser in the En-bloc Resection of Bladder Tumors overallStatus: RECRUITING date: 2023-10-16 date: 2025-10 date: 2026-10 date: 2024-04-18 date: 2024-04-18 name: Thunder Bay Regional Health Research Institute class: OTHER briefSummary: The goal of this randomized clinical trial is to determine if there is difference in pathological and clinical outcomes between MOSES and TFL in the transurethral laser enucleation of bladder tumors.
Participants will randomized to either TFL of MOSES arm for their bladder resection procedure. conditions: Urolithiasis of Bladder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: TFL name: MOSES holmium laser measure: Presence of muscularis propria measure: Incidence of inconclusive pathology measure: Tumor-free rate (TFR) measure: Total operative time measure: Total procedural time measure: Number of recurrences measure: Total blood loss measure: Rate of complications measure: Number of inconclusive pathology measure: Lasing time measure: Total energy used measure: Frequency and severity of peri-operative complications sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Thunder Bay Regional Health Sciences Centre status: RECRUITING city: Thunder Bay state: Ontario zip: P7B 6V4 country: Canada name: Rabail Siddiqui role: CONTACT phone: (807) 684-6000 email: rabail.siddiqui@tbh.net name: Hazem Elmansy role: SUB_INVESTIGATOR lat: 48.38202 lon: -89.25018 hasResults: False
nctId: NCT06373406 id: MHB036C-CP001CN briefTitle: A Study of MHB036C for Advanced Solid Tumor overallStatus: RECRUITING date: 2023-05-18 date: 2024-08 date: 2024-12 date: 2024-04-18 date: 2024-04-22 name: Minghui Pharmaceutical (Hangzhou) Ltd class: INDUSTRY briefSummary: Phase I/II, dose escalation and dose expansion study to evaluate the efficacy and safety of MHB036C in advanced malignant tumors. conditions: Advanced Solid Tumor studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 200 type: ESTIMATED name: MHB036C measure: Incidence of participants with adverse events (AE) measure: Number of participants with dose-limiting toxicity (DLT) measure: Maximum Plasma Concentration (Cmax) measure: The area under the plasma concentration-time curve (AUC) measure: To detectable anti-drug antibodies with treated subjects measure: Objective response rate (ORR) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai Chest Hospital status: RECRUITING city: Shanghai zip: 200030 country: China name: Shun Lu, MD role: CONTACT phone: 13601813062 email: shun_lu@hotmail.com lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06373393 id: 1 briefTitle: SPIRIT: Study of the Patency of Spinal aRteries After the STABILISE Technique acronym: SPIRIT overallStatus: ENROLLING_BY_INVITATION date: 2024-04-16 date: 2024-07-31 date: 2024-12-31 date: 2024-04-18 date: 2024-04-22 name: Associacao para Investigacao e Desenvolvimento da Faculdade de Medicina - CETERA class: OTHER name: Cardiovascular Center of the University of Lisbon name: Unidade Local de Saúde Santa Maria briefSummary: The aim of the study is to evaluate the impact of the stent-assisted balloon-induced intimal disruption and relamination in aortic dissection repair (STABILISE) technique in the patency of intercostal and lumbar arteries detectable on computed tomography angiography (CTA) in patients with type B aortic dissection and its correlation with the occurrence of spinal cord ischaemia (SCI).
Secondary end-point: spinal cord ischaemia conditions: Aortic Dissection conditions: Spinal Cord Ischemia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 50 type: ESTIMATED name: STABILISE measure: number of patent intercostal and lumbar arteries measure: number of patients with spinal cord ischemia sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Unidade Local de Saúde Santa Maria city: Lisbon zip: 1500 country: Portugal lat: 38.71667 lon: -9.13333 hasResults: False
nctId: NCT06373367 id: 461-24 briefTitle: Preeclampsia Educational Program Study (PrEPS) acronym: PrEPS overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-11-01 date: 2024-11-01 date: 2024-04-18 date: 2024-04-18 name: MemorialCare Health System class: OTHER briefSummary: Preeclampsia complicates approximately 8% of all pregnancies. A critical factor of outpatient monitoring is patient education; specifically, education regarding nature of the disease, ongoing short- and long-term risks, and warning signs and symptoms for worsening of disease. This study aims to compare patient knowledge using a novel illustration based app compared to standard discharge instructions. conditions: Preeclampsia conditions: Preeclampsia Severe conditions: Preeclampsia Mild conditions: Preeclampsia Postpartum studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 36 type: ESTIMATED name: Illustration based application name: Text based application measure: Preeclampsia knowledge score - short measure: Preeclampsia knowledge score - long measure: GAD-7 score measure: 72 hour BP check measure: Postpartum visit measure: Daily BP recordings measure: Accessed material measure: Unplanned readmission sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06373354 id: 2023-0924 id: NCI-2024-03341 type: OTHER domain: NCI-CTRP Clinical Registry briefTitle: Comparison of Conspicuity of Masses and Architectural Distortions Between Wide- and Narrow-angle Digital Breast Tomosynthesis Systems overallStatus: NOT_YET_RECRUITING date: 2024-09-30 date: 2025-12-31 date: 2027-12-31 date: 2024-04-18 date: 2024-04-18 name: M.D. Anderson Cancer Center class: OTHER name: Siemens Medical Solutions briefSummary: To compare narrow-angle digital breast tomosynthesis (DBT) and wide-angle DBT. conditions: Architectural Distortions conditions: Breast Tomosynthesis studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Digital Breast Tomosynthesis (DBT) measure: Safety and adverse events (AEs) sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: MD Anderson Cancer Center city: Houston state: Texas zip: 77030 country: United States name: Tanya Moseley, MD role: CONTACT phone: 713-792-5755 email: tstephens@mdanderson.org name: Tanya Moseley, MD role: PRINCIPAL_INVESTIGATOR lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06373341 id: NL85317.099.23 briefTitle: Hand and Arm Rehabilitation Using VR acronym: HANDQUEST overallStatus: RECRUITING date: 2024-01-15 date: 2026-01 date: 2027-01 date: 2024-04-18 date: 2024-04-18 name: Medical Centre Leeuwarden class: OTHER briefSummary: Patients admitted to the ICU due to critical illness often experience physical, mental, cognitive, or social issues. Research indicates that inadequate physical recovery is associated with lower handgrip strength, and hand function in ICU patients is lower compared to healthy individuals. To address this, a Virtual Reality (VR) exergame was developed to aid rehabilitation. This study aims to investigate the effect of a 4-week VR-exergame intervention on handgrip strength, hand and arm functionality, balance, mobility, and support needs in ICU patients staying for 48 hours or longer. It is a multicenter mixed-methods randomized controlled trial involving adult ICU patients. The intervention involves a 4-week VR-exergame program. Main study parameters include handgrip strength, hand and arm functionality, range of motion, balance, mobility, and support needs. The burden and risks associated with participation are minimal, as VR-based exercises are deemed safe and voluntary. Overall, the study aims to assess the effect of incorporating VR-based rehabilitation into standard care for ICU patients. conditions: Post-Intensive Care Syndrome conditions: ICU Acquired Weakness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 108 type: ESTIMATED name: VR training for arm and hand rehabilitation measure: Handgrip strength measure: Handgrip strength measure: Arm and hand functionality measure: Arm and hand functionality measure: Arm and hand range of motion measure: Balance and mobility measure: Support need and experience with VR training sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Dept of intensive care, Medical Centre Leeuwarden status: RECRUITING city: Leeuwarden state: Friesland zip: 8901 BR country: Netherlands name: Lise Beumeler, PhD role: CONTACT phone: (058) 286 6738 email: lise.beumeler@mcl.nl name: Lise Beumeler, PhD role: PRINCIPAL_INVESTIGATOR name: Carina Bethlehem, MD role: PRINCIPAL_INVESTIGATOR lat: 53.20139 lon: 5.80859 hasResults: False
nctId: NCT06373328 id: STUDY00006081 briefTitle: Post Pandemic Pneumococcal Carriage Among Children and Adults overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-09 date: 2026-03 date: 2024-04-18 date: 2024-04-18 name: University of Central Florida class: OTHER name: Merck Sharp & Dohme Corporation briefSummary: The PI propose to conduct a genomic epidemiology study of pneumococcal carriage among children and adults in a large metropolitan city. These data will allow PI to assess the post-pandemic population structure, investigate the phylogenetic relationship between isolates from children and adults, and compare pneumococcal populations across diverse geographic areas. conditions: Pneumococcal Carriage studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 900 type: ESTIMATED measure: Pneumococcal carriage prevalence and distribution of serotypes among children and adults calculated from the results of S. pneumoniae isolation using qPCR. measure: Phylogenetic relationship of pneumococcal isolates collected among child and adult populations using whole-genome sequencing libraries. measure: Putative transmission networks between children and adult populations from online questionnaires. sex: ALL minimumAge: 7 Months stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False