hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06363539 id: Adeel5 briefTitle: Silver Nitrate Versus Topical Steroid For Umbilical Granuloma overallStatus: COMPLETED date: 2022-09-20 date: 2023-03-20 date: 2023-05-01 date: 2024-04-12 date: 2024-04-12 name: Children Hospital and Institute of Child Health, Lahore class: OTHER briefSummary: Umbilical granuloma is most frequent abnormality of umbilicus in infants that is defined as a moist, fleshy and pink granulation tissue at the center of umbilicus. The most commonly used treatment for umbilical granuloma is silver nitrate cauterization. Various other treatment options for umbilical granuloma include dressing with alcohol and antiseptic solutions, topical table salt, topical steroid application, suture ligation, surgical excision, electrocautery and cryotherapy. Topical steroid ointment is easily available in market, it is cheaper and safer than silver nitrate. OBJECTIVE: To compare the outcome of treatment with silver nitrate versus topical steroid for umbilical granuloma in terms of healing after 3 weeks of treatment. MATERIALS AND METHODS Study Design: Randomized Controlled Trial Setting: Department of Pediatric Surgery, Children Hospital, Lahore Duration: 6 months after approval of synopsis \[Sept 20, 2022 till March 20, 2023\] DATA COLLECTION PROCEDURE 2 After approval of study from hospital Ethical committee \& CPSP, all patients fulfilling the inclusion criteria were admitted through the pediatric surgery outpatient department of The Children's Hospital Lahore. 354 Patients were divided in two equal groups randomly, using lottery method Group A (control group) in which silver nitrate was applied to the lesion once a week and Group B (experimental group) in which topical steroid ointment was applied to the lesion twice a day. Patients were followed after 3 weeks to see healing of umbilical granuloma. Photographs were taken before start of treatment and on regular intervals at each follow up visit. All data was collected by myself. conditions: Umbilical Granuloma studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: randomized control trial primaryPurpose: TREATMENT masking: NONE count: 354 type: ACTUAL name: Clobetasol Propionate .05 Mg in 100 mL TOPICAL LOTION name: Silver Nitrate measure: healing sex: ALL minimumAge: 1 Month maximumAge: 1 Year stdAges: CHILD facility: Children Hospital city: Lahore state: Punjab zip: 42000 country: Pakistan lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06363526 id: UMalagaDRIP briefTitle: Effectiveness of 5-week Digital Respiratory Practice in a Group of Children With Duchenne Muscular Dystrophy and Becker Muscular Dystrophy. acronym: DMDrespy2024 overallStatus: NOT_YET_RECRUITING date: 2024-05-05 date: 2024-10-30 date: 2024-11-30 date: 2024-04-12 date: 2024-04-12 name: University of Malaga class: OTHER briefSummary: The purpose of this study is to analyze the effectiveness of a 5-weeks respiratory digital intervention program in patients with Duchenne muscular dystrophy and Becker muscular dystrophy. conditions: Duchenne Muscular Dystrophy conditions: Becker Muscular Dystrophy conditions: Muscular Dystrophy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: 12 participants were randomized to follow a digital respiratory physiotherapy program for 5 weeks. The participants were evaluated at the beginning and at the end of the study, and the results will be measured before and after each intervention during the study. primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: Digital respiratory intervention program measure: Analyze the improvement of the forced vital capacity (FVC). measure: Perform an anthropometric study of the patient's characteristics, taking into account weight; and also a general physical examination. measure: Perform an anthropometric study of the patient's characteristics, taking into account age. measure: Perform an anthropometric study of the patient's characteristics, taking into account height. measure: Perform an anthropometric study of the patient's characteristics, taking into account sex. measure: Examine changes in forced expiratory pressure measure: Analyze changes in maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP). measure: Check if there are changes in the sniff nasal inspiratory pressure (SNIP) measure: Evaluate the fatigue in patients using an EPInfant test. measure: Evaluate the quality of life of patients using a scale called "Kindscreen-52". sex: ALL minimumAge: 5 Years maximumAge: 20 Years stdAges: CHILD stdAges: ADULT facility: Rocío Martín-Valero city: Málaga country: Spain lat: 36.72016 lon: -4.42034 hasResults: False
nctId: NCT06363513 id: SUR2567-0150 briefTitle: The Efficacy of Aescin in Combination With MPFF in the Early Control of Bleeding From Acute Internal Hemorrhoids, A Randomized Controlled Trial overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-05 date: 2024-05 date: 2024-04-12 date: 2024-04-12 name: Chiang Mai University class: OTHER briefSummary: Hemorrhoidal disease, characterized by symptomatic enlargement and distal displacement of anal cushions, has been a subject of recognition and management for centuries. The etymology of "hemorrhoid" is traced back to the Greek words haima (blood) and rhoos (flow). Prevalent in over 20% of the population across various life stages, this anorectal condition impacts both genders. The multifaceted development of the disease incorporates theories encompassing abnormal dilation of hemorrhoidal plexuses, distension of arteriovenous anastomoses, prolapse of anal pads, and a myriad of genetic, anatomical, dietary, and lifestyle factors. Manifestations range from venous distension to bleeding and thrombosis, with classification based on location (internal/external/combined) and degree of prolapse (grade 1-4).
Upon comprehensive history-taking and examinations, including digital rectal and proctoscope assessments, a definitive diagnosis is established, leading to the treatment phase. Although outpatient procedures demonstrate efficacy, patients may persist with pain and discomfort. Medical intervention assumes significance for stages 1 and 2, incorporating approaches such as rubber-band ligation, injection sclerotherapy, and dietary modifications. Micronized Purified Flavonoid Fraction (MPFF), integral to hemorrhoid treatment, has been scrutinized for its ability to mitigate pathogenic processes culminating in acute bleeding. The stagnation of blood in vascular plexuses prompts an inflammatory response, activating white cells and increasing vessel wall permeability. MPFF's flavonoid compounds are posited to alleviate bleeding by augmenting venous tone, reducing stasis, inhibiting inflammatory mediators, and enhancing lymphatic drainage\[8\]. Multiple trials substantiate MPFF's efficacy in ceasing bleeding, alleviating symptoms, and preventing hemorrhoid relapse.
Aescin, a saponin mixture found in Aesculus hippocastanum (horse chestnut). The primary active component, β-aescin, contributes to the plant's medicinal attributes. Experimental investigations in animal models underscore its anti-edematous, anti-inflammatory, and venotonic properties, attributed to molecular mechanisms facilitating ion entry into channels and elevating venous tension. While the therapeutic benefits of aescin for hemorrhoids are acknowledged, the absence of randomized control trials impedes the conclusive validation of its efficacy. In the realm of diverse treatment options, this proposed randomized controlled trial aims to assess the comparative effectiveness of combining aescin with MPFF versus MPFF alone in managing hemorrhoid-related symptoms. The study aspires to furnish valuable insights for refining therapeutic strategies in the management of hemorrhoids and enhancing patient outcomes. conditions: Anorectal Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Aescin in Horse Chestnut name: Flavonoid measure: Cessation of bleeding sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Maharaj Chiang Mai hospital city: Chiangmai state: Maung zip: 50200 country: Thailand name: WITCHA VIPUDHAMORN, FRCS role: CONTACT phone: 0863645085 email: witcha.vip@cmu.ac.th lat: 18.79038 lon: 98.98468 hasResults: False
nctId: NCT06363500 id: ChantalIRCB briefTitle: Characterization of HIV-1 Reservoirs in HIV-1 Non-B Infected Adolescents on ART in Cameroon acronym: AVIR overallStatus: COMPLETED date: 2021-11-01 date: 2023-10-30 date: 2023-11-30 date: 2024-04-12 date: 2024-04-12 name: Chantal Biya International Reference Centre for Research on Prevention and Management of HIV/AIDS class: OTHER_GOV briefSummary: Background: Combination antiretroviral therapy (cART) can bring HIV-1 in blood plasma to level undetectable by standard tests and allow a near-normal life expectancy for HIV-infected individuals. Unfortunately, cART is not curative, as within a few weeks of treatment cessation, HIV viremia in most patients rebounds except for rare elite or post-treatment controllers of viremia. The primary source of this rebound is the highly stable reservoir of latent yet replication-competent HIV-1 proviruses integrated into the genomic DNA of resting memory CD4+ T cells. To achieve a cure for HIV, understanding the cell reservoir environment is of paramount importance. The size and nature of viral reservoir might vary per timing of therapy, therapeutic response, ART duration, and immune response. Mechanisms of reservoir maintenance generally depend on levels/type of immune recognition, dynamics of viral persistence are different between pediatric and adult populations, owing to, but not limited to, types/numbers of target cells, efficiency in clearing HIV-infected cells, plasma viremia and HIV drug resistance patterns. This difference could become more evident as these children grow toward adolescence (increasing population due to ART benefits), a stage during which suboptimal adherence is frequent, leading to viral rebound and archiving of resistant patterns.
Objectives: We plan to conduct a cross sectional study with the aim to characterize HIV reservoirs and their variability according to virological and immunological profiles of non-B HIV-1 vertically infected adolescents receiving antiretroviral therapy. Specifically, we shall (1) evaluate the size of HIV reservoir; (2) Determine HIV-1 genetic variability and drug resistance in cellular reservoirs; (3) Characterize immune activation/inflammation of HIV infected adolescents.
Methods: We plan to conduct an observational and comparative study involving 90 HIV-1 non-B infected adolescents aged 10-19 years vertically infected, have been on ART for at least 12 months selected from a cohort of the ongoing EDCTP-READY study; intravenous blood will be collected for CD4/CD8 count, plasmatic viral load, PBMCs isolation, immune activation/inflammatory markers, genotyping and Viral reservoir quantification. We will as well recruit a group of 30 HIV-negative adolescents as control for immunological profiling.
Overall impact: Our findings will help in advancing knowledge on HIV reservoir, in terms of size and genetic variability in adolescents living with HIV (ADLHIV). Such evidence will also help in understanding the effects of ART timing and duration on the size of reservoirs among ADLHIV, a unique population from whom findings generated will largely contribute in designing functional cure strategies in this vulnerable population. conditions: Characterization of HIV Reservoirs in Adolescents studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 140 type: ACTUAL name: non applicable measure: Archived HIV drug resistance mutations measure: HIV-1 reservoirs measurement sex: ALL minimumAge: 10 Years maximumAge: 19 Years stdAges: CHILD stdAges: ADULT facility: Chantal Biya International Reference Centre city: Yaounde state: Centre zip: 99999 country: Cameroon lat: 3.86667 lon: 11.51667 hasResults: False
nctId: NCT06363487 id: R87970/RE001 briefTitle: Semaglutide and Cognition in Healthy Volunteers acronym: OxSENSE overallStatus: NOT_YET_RECRUITING date: 2024-04-08 date: 2024-04-08 date: 2024-06-08 date: 2024-04-12 date: 2024-04-12 name: University of Oxford class: OTHER name: NIHR Oxford Health Biomedical Research Centre briefSummary: Semaglutide is a glucagon-like peptide 1 receptor agonist (GLP-1RA). It is a safe medication approved for use in type-2 diabetes mellitus (T2DM) and obesity. Primarily, it works by counteracting insulin-resistance and inducing weight loss. It also acts on several other interconnected neurobiological, immunological (esp. inflammatory), endocrine-metabolic, and gut-brain axis processes that play a role in depressive symptoms. Its effects on cognition and energy are currently unknown. In this study we are using semaglutide as an experimental tool to further investigate these relationships. conditions: Cognitive Change studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Semaglutide, 0.5 mg/mL name: Placebo, 0.9% NaCl 1.5mL measure: Reward (learning) measure: Reward (effort-based) measure: Reward (primary) measure: Emotional processing measure: Emotional impulsivity measure: Memory (short- and medium-term) processing measure: Memory (working) processing measure: Energy/activity sex: ALL minimumAge: 21 Years maximumAge: 55 Years stdAges: ADULT facility: Department of Psychiatry, University of Oxford city: Oxford state: Oxfordshire zip: OX3 7JX country: United Kingdom lat: 51.75222 lon: -1.25596 hasResults: False
nctId: NCT06363474 id: UHS 5532 briefTitle: Cisternostomy Vs Decompressive Craniectomy for Severe Traumatic Brain Injury overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-05-01 date: 2024-04-12 date: 2024-04-12 name: University of Health Sciences Lahore class: OTHER briefSummary: The objective of this clinical study is to compare the outcomes of two neurosurgical interventions, Cisternostomy and Decompressive Craniectomy (DC), for the management of severe Traumatic Brain Injury (TBI), assessed using the Glasgow Outcome Scale (GOS). Severe TBI presents challenges in managing intracranial pressure (ICP) and cerebral perfusion, often requiring surgical intervention. DC involves the removal of a section of the skull to reduce ICP, while Cisternostomy, a technique rooted in microsurgery, aims to alleviate brain edema and lower ICP by creating additional space for cerebrospinal fluid (CSF) circulation.
This prospective study will be conducted at the Department of Neurosurgery, Punjab Institute of Neurosciences, Lahore. Patients meeting inclusion criteria will be randomized into Group A (DC) and Group B (Cisternostomy) following brain CT scans. Clinical evaluation will include regular follow-ups for 6 months post-surgery, recording data on GOS, duration of mechanical ventilation, ICU, and hospital stays. Analysis will be performed using SPSS 24, comparing outcomes between groups using Chi-square test and t-test. A significance level of p≤0.05 will be applied.
It is hypothesized that Cisternostomy, as an adjunct to traditional TBI management, will effectively reduce ICP, resulting in improved GOS and reduced complications postoperatively, including decreased duration of mechanical ventilation and ICU stay, with sustained improvement observed at 6 months conditions: Severe Traumatic Brain Injury studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The intervention model of this study is a parallel model. Patients meeting inclusion criteria are enrolled from the neurosurgery department of Punjab Institute of Neurosciences, Lahore. After obtaining consent, patients undergo detailed assessments and investigations. They're randomly assigned to Group A (decompressive craniectomy) or Group B (cisternostomy). Both procedures are performed by a single surgical team under anesthesia. Postoperatively, patients are monitored for mechanical ventilation duration, ICU and hospital stay lengths, and Glasgow Outcome Scale at discharge. This model enables outcome comparison between intervention groups while controlling confounding variables. primaryPurpose: TREATMENT masking: NONE count: 190 type: ESTIMATED name: Decompressive Craniectomy name: Cisternostomy measure: comparison of patient outcomes between the two intervention groups (Decompressive Craniectomy and Cisternostomy) in terms of the Glasgow Outcome Scale (GOS). sex: ALL maximumAge: 60 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06363448 id: Soh-Med-24-3-04PD briefTitle: Yamani Technique Versus Proline Mesh for Intraocular Lens Scleral Fixation in Aphakia overallStatus: RECRUITING date: 2024-01-01 date: 2024-06-30 date: 2024-07-30 date: 2024-04-12 date: 2024-04-12 name: Sohag University class: OTHER briefSummary: The study aims to describe a new method of sulcus fixation of intraocular lenses (IOLs) using a prolene mesh and to compare its outcomes with Yamani technique. conditions: Aphakia, Postcataract studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 20 type: ESTIMATED name: Yamani Technique versus Prolene Mesh for Intraocular Lens Scleral Fixation in Aphakia measure: Best corrected visual acuity (BCVA) in LogMAR sex: ALL minimumAge: 40 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ophthalmology department, Sohag University status: RECRUITING city: Sohag zip: 82511 country: Egypt name: Elshimaa A.Mateen role: CONTACT phone: 0201282223427 email: elshimaa.moussa@yahoo.com lat: 26.55695 lon: 31.69478 facility: Elshimaa A.Mateen status: RECRUITING city: Sohag country: Egypt name: Elshimaa A.Mateen, Doctor role: CONTACT phone: 0201282223427 email: elshimaa.moussa@yahoo.com lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06363435 id: #2022-01302-02-PSMA briefTitle: AI-based Measurements of Tumour Burden in PSMA PET-CT overallStatus: RECRUITING date: 2024-03-29 date: 2031-03 date: 2033-03 date: 2024-04-12 date: 2024-04-12 name: Elin Tragardh class: OTHER name: Lund University briefSummary: The primary aim of the present study is to evaluate how automatically calculated (by an AI-based method) tumour burden, measured as tumour volume (TV) and as tumour uptake (TU: TV x SUVmean) in the prostate/prostate bed, pelvic lymph nodes, distant lymph nodes, bone and as the total tumour burden predicts overall survival (OS) in patients with prostate cancer (newly diagnosed and patients with biochemical recurrence). conditions: Prostate Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1500 type: ESTIMATED name: AI-based detection and quantification of suspected tumour/metastases in PSMA PET/CT scans measure: Tumour burden (cm3) in relation to overall survival measure: Tumour burden (cm3) in relation to biochemical recurrence measure: Number of tumours/metastases in relation to OS measure: Comparing two different segmentation methods in relation to OS measure: Comparing total tumour burden (cm3) measured manually and by the AI-based mehtod sex: MALE minimumAge: 20 Years maximumAge: 120 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Skåne University Hospital status: RECRUITING city: Lund country: Sweden name: Elin Tragardh, Prof role: CONTACT phone: +4640338724 email: elin.tragardh@skane.se lat: 55.70584 lon: 13.19321 facility: Skåne university hospital status: RECRUITING city: Malmö country: Sweden name: Elin Tragardh, Prof role: CONTACT phone: +4640338724 email: elin.tragardh@skane.se lat: 55.60587 lon: 13.00073 hasResults: False
nctId: NCT06363422 id: JY2024-012 briefTitle: The Value of Epicanthoplasty on the Modification of Upper-eyelid Appearance overallStatus: COMPLETED date: 2024-01-01 date: 2024-03-15 date: 2024-04-01 date: 2024-04-12 date: 2024-04-12 name: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University class: OTHER briefSummary: In East Asian populations, the combination of an epicanthic fold and mono-eyelid is one of their anatomical characteristics. Misalignment of the orbicularis oculi muscle and fibrous connections leads to longitudinal tension, forming the epicanthic fold. The epicanthic fold may diminish the aesthetic effects of eyelid cosmetic surgery, shorten the horizontal length, and affect the postoperative shape of double eyelids. As upper eyelid cosmetic surgery is one of the most common cosmetic procedures in Asia, there is increasing attention on the modification of the epicanthic fold and its impact on the formation of double eyelids. conditions: Patient Satisfaction conditions: Epicanthus; Fold studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 14 type: ACTUAL name: Epicanthoplasty measure: inter-epicanthal distance (IED) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai ninth people's hospital city: Shanghai country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06363409 id: 2023-1353 briefTitle: The Acute and Accumulative Effects of Snack Foods on Exercise Recovery overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-06-01 date: 2027-01-01 date: 2024-04-12 date: 2024-04-12 name: San Diego State University class: OTHER briefSummary: The purpose of the research is two-fold. One goal is to determine if post-exercise almond or cereal bar consumption can promote muscle gain as well as increasing muscular strength throughout an eight-week weight training program. The other goal is to assess the short-term effects of almonds or cereal bar on recovery that may explain the overall long-term adaptations. conditions: Muscle Strength studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 60 type: ESTIMATED name: Cereal Bar as a recovery food snack name: Almond measure: delayed onset of muscle soreness measure: markers of muscle damage measure: changes in strength measure: changes in body composition sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT hasResults: False
nctId: NCT06363396 id: K 2023-7081 briefTitle: Fatigue and Cognitive Dysfunction After Allogeneic Stemcell Transplantation, Prospective PET Study overallStatus: RECRUITING date: 2024-02-22 date: 2026-02-22 date: 2027-02-22 date: 2024-04-12 date: 2024-04-12 name: Karolinska Institutet class: OTHER name: Karolinska University Hospital briefSummary: This study is the academic study and continuation and further development of a prior project under the leadership of Professor LeBlanc. Patients undergoing allogenic stem cell transplantation are followed up in the outpatient clinic. Here, patients are offered participation the fatigue study measuring both fatigue and cognitive impairment systematically by international standard. Previous study by Boberg et al suggested distinct mRNA and proteomic profiles segregating fatigued from non-fatigued patients as well as patients with or without cognitive impairment. A larger well-defined patient cohort is necessary to confirm these results. Investigators aim to identify specific sets of proteins in the CSF that can serve as potential biomarkers of cognitive dysfunction and/or fatigue. This will be performed with two methods: