hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06293079 id: BiruniUnive id: Researcher type: OTHER domain: Biruni University briefTitle: The Effect of Hybrid Telerehabilitation-Based Structured Exercise Programs in Patients With Multiple Sclerosis overallStatus: RECRUITING date: 2023-08-30 date: 2024-02-12 date: 2024-08-30 date: 2024-03-05 date: 2024-03-05 name: Biruni University class: OTHER briefSummary: The aim of our study is to compare the effects of hybrid telerehabilitation (TR)-based exercise program applied in patients with MS, only TR-based exercise program and only clinical-based exercise program on walking speed, functional capacity, peripheral muscle saturation and fatigue. Forty-five individuals with MS with EDSS scores between 0-4 will be included in the study. The patients will be randomized into three groups: Group A, Group B, and Group C. Group A- Telerehabilitation group will be included in an aerobic and strengthening exercise program over the synchronized videoconference system with the physiotherapist 2 days a week for 8 weeks. Group B- Hybrid Telerehabilitation group will be included in the same exercise program 2 days a week for 2 weeks in the clinic, and will continue remotely over the synchronized videoconference system with the physiotherapist 2 days a week for 6 weeks. In Group C-Clinical Based Rehabilitation group, the same exercise program will be applied in the clinic 2 days a week for 8 weeks. In addition to aerobic and strengthening exercises, traditional breathing exercises and energy conservation techniques will be taught to all three groups within the scope of patient education Demographic and clinical information of all patients to be included in the study will be recorded with a "Case Evaluation Form". The gait speed of the patients will be evaluated with the Timed 25-step walking test, their functional capacity with the 6-minute walking test, their Quadriceps muscle activation will be tested with the EMG muscle activation, the fatigue will be evaluated with the "Modified Fatigue Impact Scale", and the Patient Satisfaction with the "Global Rating Scale". In addition, feasibility evaluation will be made by calculating the attendance rate of the patients to the programs. All data will be evaluated by statistical analysis methods. conditions: Multiple Sclerosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized Controlled Trial primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 45 type: ESTIMATED name: Exercise Program measure: Gait Speed measure: Functional Capacity measure: EMG muscle activation measure: EMG muscle activation measure: Modified Fatigue Impact Scale measure: Global Rating of Change Scale sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Biruni University status: RECRUITING city: İstanbul country: Turkey name: Güzin Kaya Aytutuldu role: CONTACT phone: 05366265884 email: guzinkaya14@gmail.com lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06293066 id: KCH23-257 briefTitle: Performance of Ultrasound in Women With Postmenopausal or Abnormal Uterine Bleeding Between White and Black Ethnic Groups- a Retrospective Cohort Study. overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-31 date: 2024-03-01 date: 2024-03-01 date: 2024-03-05 date: 2024-03-05 name: King's College Hospital NHS Trust class: OTHER briefSummary: Primary Objective:
To assess whether there is a higher incidence of uninformative ultrasound in black vs white women conditions: Postmenopausal Bleeding conditions: Endometrial Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 330 type: ACTUAL name: Ultrasound measure: To assess whether there is a higher incidence of uninformative ultrasound in black vs white women sex: FEMALE minimumAge: 45 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Suite 8, King's College Hospital city: London zip: SE5 9RS country: United Kingdom lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06293053 id: PKM17836 id: U1111-1287-7255 type: REGISTRY domain: ICTRP briefTitle: A Study to Investigate the Pharmacokinetics and Safety of Dupilumab in Participants ≥6 Months to <18 Years of Age With Prurigo Nodularis overallStatus: NOT_YET_RECRUITING date: 2024-02-28 date: 2027-10-28 date: 2027-11-03 date: 2024-03-05 date: 2024-03-05 name: Sanofi class: INDUSTRY name: Regeneron Pharmaceuticals briefSummary: This is a Phase 3, multicenter, open-label, pharmacokinetics (PK)/safety study.
The total number of planned study visits for each participant will be 6. conditions: Prurigo Nodularis studyType: INTERVENTIONAL phases: PHASE3 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 18 type: ESTIMATED name: Dupilumab measure: Concentration of dupilumab in serum measure: Incidence of treatment-emergent adverse events (TEAEs) or serious adverse events (SAEs) measure: Incidence of anti-drug antibodies (ADA) to dupilumab over time sex: ALL minimumAge: 6 Months maximumAge: 17 Years stdAges: CHILD hasResults: False
nctId: NCT06293027 id: IMAGINER FXS briefTitle: Optical Imaging as a Tool for Monitoring Brain Function in Fragile X Syndrome overallStatus: RECRUITING date: 2023-06-01 date: 2025-06-15 date: 2025-12-15 date: 2024-03-05 date: 2024-03-05 name: IRCCS Fondazione Stella Maris class: OTHER briefSummary: The objective of this project is to explore the potential of functional near- infrared spectroscopy (fNIRS) as innovative functional biomarker for clinical trial readiness in Fragile X Syndrome (FXS) that is still without cure. The limited availability of objective and quantitative biomarkers to monitor brain function poses challenges to advancing therapeutic research. With clinical trials on the horizon, the need for precise measurement to evaluate treatment efficacy is pressing. The investigators seek to address this gap by assessing the prognostic reliability of both resting and task- evoked fNIRS. The primary objectives of this pilot study are: 1. to determine the feasibility of fNIRS in individuals with FXS; 2. to collect pilot data on individuals with FXS to determine the patterns of cerebral oxygen consumption as measured by fNIRS; 3. to compare cerebral oxygen consumption changes at rest and from visual/auditory tasks in affected individuals versus age-appropriate healthy volunteers. The secondary objectives of this study are: 1. to correlate cerebral oxygen consumption changes from visual/auditory task in affected individuals to other measures of disease state (e.g., neuropsychological assessment, disease- specific severity rating scales); 2. to examine test-retest reliability of our fNIRS measures in both affected individuals and healthy controls. conditions: Fragile X Syndrome studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 40 type: ESTIMATED measure: Resting-state functional connectivity measure: Amplitude of sensory-evoked hemodynamic responses measure: Correlation between neurophysiology endpoints and the response on neuropsychological scale. sex: MALE minimumAge: 2 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Fondazione Stella Maris status: RECRUITING city: Marina di Pisa-Tirrenia-Calambrone state: Toscana zip: 56128 country: Italy name: Roberta Battini, MD role: CONTACT phone: +39 050886282 email: roberta.battini@fsm.unipi.it name: Laura Baroncelli, PhD role: CONTACT phone: +39 050886233 email: laura.baroncelli@fsm.unipi.it name: Elena Scaffei, MD role: SUB_INVESTIGATOR lat: 43.62719 lon: 10.29204 hasResults: False
nctId: NCT06293014 id: QLMA-CRC-IIT-001 briefTitle: TAS-102 Combined With Bevacizumab for Second-line Maintenance Treatment of Advanced Colorectal Cancer overallStatus: RECRUITING date: 2024-02-23 date: 2025-10-15 date: 2026-11-28 date: 2024-03-05 date: 2024-03-05 name: Henan Cancer Hospital class: OTHER_GOV briefSummary: This study is a randomized, controlled, open-label, multicentre clinical study. This study is designed to evaluate the efficacy and safety of TAS-102 combined with bevacizumab as second-line maintenance therapy versus standard chemotherapy combined with bevacizumab as second-line continuous therapy in advanced colorectal cancer after second-line induction therapy. conditions: Colorectal Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 224 type: ESTIMATED name: TAS-102+bevacizumab name: Standard chemotherapy+bevacizumab measure: Time to treatment failure (TTF) measure: Objective response rate (ORR) measure: Disease control rate (DCR) measure: Duration of Response (DoR) measure: Progression-free survival (PFS) measure: Overall survival（OS） measure: Adverse Events measure: European Quality of Life Five Dimensions Five Level Scale Questionnaire (EQ-5D-5L) measure: European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Henan Cancer Hospital/The affiliated Cancer Hospital of ZhengZhou university status: RECRUITING city: ZhengZhou state: Henan zip: 450008 country: China name: Ying Liu, MD role: CONTACT phone: +86-13783604602 email: Yaya7207@126.com lat: 34.75778 lon: 113.64861 hasResults: False
nctId: NCT06293001 id: SBA 23/349 briefTitle: Cross-Cultural Adaptation, Validity and Reliability of the Turkish Version of the ADAP Shoulder Scale overallStatus: RECRUITING date: 2023-11-28 date: 2024-04-26 date: 2024-04-26 date: 2024-03-05 date: 2024-04-29 name: Hacettepe University class: OTHER briefSummary: Shoulder pain is a common musculoskeletal problem that increases disability and decreases quality of life in addition to socio-economic impact. Chronic pain is defined as pain lasting longer than three months. Chronic pain is a multidimensional and complex experience. According to this model, chronic pain is a multidimensional and complex experience. This experience may be accompanied by different pain beliefs, pain avoidance behaviours, pain-related fear of movement, anxiety and depression. Many conditions involving the shoulder complex including traumatic and non-traumatic pain, subacromial impingement, postoperative pain, rotator sheath tears, rotator sheath tendinopathy, shoulder arthritis, adhesive capsulitis, shoulder instabilities may lead to pain-related fear of movement.
Until now, pain-related fear and avoidance behaviours in patients with shoulder pain have been evaluated with the Tampa Kinesiophobia Scale, Pain Avoidance Beliefs Scale and Fear of Pain Scale. However, only patients with low back pain were included in the development of these scales. There was no scale developed specifically for shoulder pain. To fill this gap in the literature, Ansanello et al. developed the "Avoidance Daily Activities Photo Scale for Patients With Shoulder Pain (ADAP)" scale to evaluate pain avoidance behaviours in individuals with shoulder pain. Cross-cultural adaptation, validity and reliability of the Turkish version of the ADAP scale has not been studied.
The aim of our study was to perform cross-cultural adaptation, validity and reliability of the Turkish version of the Avoidance of Daily Activities Photo Scale for Patients with Shoulder Pain (ADAP Shoulder Scale). conditions: Questionnaire conditions: Shoulder Pain conditions: Validity conditions: Reliability studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 162 type: ESTIMATED name: No intervention measure: Investigating Cross-Cultural Adaptation, Validity and Reliability of the Turkish Version of the Avoidance of Daily Activities Photo Scale for Patients with Shoulder Pain (ADAP Shoulder Scale) sex: ALL minimumAge: 18 Years maximumAge: 64 Years stdAges: ADULT facility: Elif Turgut status: RECRUITING city: Ankara zip: 06300 country: Turkey name: Elif Turgut, Assoc. Prof. role: CONTACT phone: +90 (544) 264 56 00 email: elifcamci@gmail.com name: Pınar KUYULU HAKSAL, Master role: SUB_INVESTIGATOR name: Kübra CAYLAN GURSES, Master role: SUB_INVESTIGATOR name: Birgül DINGIRDAN, Master role: SUB_INVESTIGATOR name: Büşra PAKOZ, Master role: SUB_INVESTIGATOR name: Irem DUZGUN, Proffessor role: SUB_INVESTIGATOR lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06292975 id: RS210 - 326709 briefTitle: Exercise for Improving Radiotherapy Efficacy in Rectal Cancer overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-02 date: 2026-02 date: 2024-03-05 date: 2024-04-24 name: University of Hull class: OTHER name: Hull University Teaching Hospitals NHS Trust briefSummary: This is a single arm feasibility study of exercise for improving short- course neoadjuvant radiotherapy efficacy in people diagnosed with locally advanced rectal cancer. The study aims to recruit up to 30 patients from the Queen's Centre for Oncology and Haematology of Castle Hill Hospital, Cottingham, diagnosed with locally advanced rectal cancer. Consenting patient's will be provided with a 7 weeks course of structured aerobic exercises and resistance training in the periods before, during and after their radiotherapy treatment. The patients will be followed up for 6 months post short course neoadjuvant radiotherapy, with a total of 3 assessment periods. conditions: Locally Advanced Rectal Carcinoma studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Feasibility study primaryPurpose: BASIC_SCIENCE masking: NONE count: 30 type: ESTIMATED name: Supervised Vigorous intensity aerobic interval exercise measure: Recruitment rate measure: Attendance rate measure: withdrawal rate measure: Serum Carcinoembryonic antigen levels measure: Quality of life assessment measure: Quality of life assessment measure: Physical activity levels sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06292962 id: SH-34988389 briefTitle: Evaluating the Impact of Vagus Nerve Stimulation on Diabetic Peripheral Neuropathic Pain acronym: VNSDPN overallStatus: COMPLETED date: 2023-10-01 date: 2024-03-01 date: 2024-03-03 date: 2024-03-05 date: 2024-04-22 name: Saima Abass Tahammal class: OTHER name: Al Ain University briefSummary: The purpose of the study is to investigate the effects of non-invasive invasive vagal nerve stimulation on diabetic peripheral neuropathic pain in people with diabetes. conditions: Diabetes Mellitus conditions: Diabetic Neuropathies conditions: Type2diabetes conditions: Neuropathic Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: a randomized, double-blinded, sham-controlled, parallel group clinical trial whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 165 type: ACTUAL name: non-invasive transcutaneous vagal nerve stimulation (tVNS) name: Sham device measure: Neuropathic pain scores measure: Quality of life score sex: ALL minimumAge: 30 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shifa Hospital city: Lahore country: Pakistan lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06292936 id: 30692 briefTitle: RemI for Post-Bariatric Surgery Weight Regain overallStatus: NOT_YET_RECRUITING date: 2024-03-04 date: 2027-12-31 date: 2028-04-01 date: 2024-03-05 date: 2024-03-05 name: Temple University class: OTHER name: Rush University briefSummary: The goal of this clinical trial is to test the effectiveness of remotely-delivered interventions (utilizing acceptance-based behavioral treatment skills (ABTi)) amongst bariatric surgery populations who are experiencing weight regain postoperatively (\> 5% from their lowest postoperative weight and after postoperative Month 6). Investigators aim to evaluate ABTi's efficacy for reversing weight regain and its effect on targeted weight control behaviors and weight-related comorbidities by comparing participants randomly assigned ABTi (n = 100) to those assigned to a Control group that also receives brief phone calls but that focus on reiterating instruction on the dietary and behavioral changes required of surgery and initially taught preoperatively (C, n = 100).
3. Exploratory - To test ABTi's theoretical mechanisms of action, including a) effects of theory-based active ingredients (i.e., acceptance, defusion, values clarity, mindfulness) on weight outcomes and b) changes in impact of internal states (i.e., hunger, cravings) on eating behavior. conditions: Obesity conditions: Bariatric Surgery Candidate studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 200 type: ESTIMATED name: Acceptance-Based Behavioral Intervention measure: Weight measure: Caloric Intake measure: Eating Behavior - Cognitive Constraint measure: Eating Behavior - Disinhibition measure: Eating Behavior - Hunger measure: Physical Activity measure: Weight-Related Medical Comorbidities - Number of participants with hypertension measure: Weight-Related Medical Comorbidities - Number of participants with diabetes measure: Weight-Related Medical Comorbidities - Number of participants with hypercholesterolemia measure: Weight-Related Medical Comorbidities - Number of participants with hyperlipidemia measure: Mechanisms of Action (Exploratory) - Acceptance of food-related internal experiences measure: Mechanisms of Action (Exploratory) - Mindfulness measure: Mechanisms of Action (Exploratory) - Defusion measure: Mechanisms of Action (Exploratory) - Values clarity measure: Mechanisms of Action (Exploratory) - Depressive symptoms measure: Mechanisms of Action (Exploratory) - Anxiety measure: Mechanisms of Action (Exploratory) - Internal states measure: Mechanisms of Action (Exploratory) - Maladaptive eating behaviors sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Rush University city: Chicago state: Illinois zip: 60612 country: United States name: Lauren Bradley, PhD role: CONTACT phone: 312-942-2714 email: lauren_e_bradley@rush.edu lat: 41.85003 lon: -87.65005 facility: Temple University city: Philadelphia state: Pennsylvania zip: 19104 country: United States name: David B Sarwer, PhD role: CONTACT phone: 215-707-8632 email: dsarwer@temple.edu name: Sarah R Fischbach, MPH role: CONTACT phone: 215-707-8633 email: sarah.fischbach@temple.edu lat: 39.95233 lon: -75.16379 hasResults: False
nctId: NCT06292923 id: TILS-021 briefTitle: A Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Sclerosis Patients overallStatus: RECRUITING date: 2023-11-15 date: 2024-11 date: 2024-11 date: 2024-03-05 date: 2024-03-19 name: Tiziana Life Sciences LTD class: INDUSTRY briefSummary: Foralumab is a human anti-CD3 monoclonal antibody being developed for the treatment of autoimmune and inflammatory diseases.
2. To investigate the effect of foralumab relative to placebo on the change from baseline \[18F\]PBR06-positron emission tomography (PET) scans for microglial activation, after 12 weeks (3) months of study treatment. conditions: Secondary Progressive Multiple Sclerosis studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: The treating physician, study staff, and patients will be blinded to treatment. The research pharmacy at each site will have the treatment code assignments. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 54 type: ESTIMATED name: Foralumab name: Placebo measure: The number of patients with adverse event (AE) reports. measure: Changes in the Total Nasal Symptom Score (TNSS). measure: Change from baseline for [18F]PBR06-positron emission tomography (PET) scans for microglial activation after 12 weeks (3 months) of study treatment. measure: Changes in the Expanded Disability Status Scale (EDSS). measure: Changes in the Multiple Sclerosis Functional Composite-4 (MSFC-4). measure: Changes in the Modified Fatigue Impact Scale (MFIS). measure: Changes in the mean number of gadolinium-enhancing lesions per T1-weighted MRI scan, as measured by 3T MRI. measure: Changes in percent brain volume change by 3T MRI analysis pipeline between the Screening Visit (Baseline) and after 3 months of treatment, as measured by 3T MRI. measure: Paramagnetic rim lesions by quantitative susceptibility mapping sequences on MRI, as measured by 3T MRI (if center is able). sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Brigham and Women's Hospital status: RECRUITING city: Boston state: Massachusetts zip: 02115 country: United States name: Niveditha Gopalakrishnan role: CONTACT phone: 617-732-5588 email: foralumab@mgb.org name: Tanuja Chitnis, M.D role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06292910 id: REC 64-299-1-1 briefTitle: Central Venous to Arterial CO2 Difference and Low Cardiac Output Syndrome Related Outcomes in Children After Cardiac Surgery acronym: VACO2 overallStatus: COMPLETED date: 2021-08-08 date: 2023-12-21 date: 2023-12-26 date: 2024-03-05 date: 2024-03-05 name: Prince of Songkla University class: OTHER briefSummary: The goal of this clinical trial is to compare the capability of 3 different bedside surrogates in children who underwent cardiac surgery and were admitted in intensive care unit. These test are lactate, oxygen saturation from central venous and the carbon dioxide gap between central venous and arterial.
The main questions is which one is the best prognostication for post operation poor outcomes Participants will be taken routine blood test for post cardiac care (at ICU arrival, 6, 12, and 24 hour post operation) and follow the their outcomes. There is no any intervention or drug in this research conditions: Congenital Heart Disease conditions: Perioperative/Postoperative Complications conditions: Lactate Blood Increase studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 136 type: ACTUAL name: arterial and central venous blood gas analysis, lactate measure: number of participant who developed low cardiac output syndrome related poor outcomes within 24 hour post operation measure: ventilator days measure: inotrope days measure: length of stay in ICU sex: ALL minimumAge: 1 Day maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Faculty of Medicine, Prince of Songkla University city: Hat Yai state: Songkhla zip: 90110 country: Thailand lat: 7.00836 lon: 100.47668 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-11-05 uploadDate: 2024-02-09T09:23 filename: Prot_SAP_000.pdf size: 745529 hasResults: False
nctId: NCT06292897 id: 3312 briefTitle: Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression acronym: OBESITA'&PCa overallStatus: RECRUITING date: 2023-03-20 date: 2026-09-15 date: 2027-01-15 date: 2024-03-05 date: 2024-03-05 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico class: OTHER name: National Research Council briefSummary: Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI \> 27.5) and non-severely overweight/normoweight (BMI \< 27.5) patients affected by prostate carcinoma.