The "RIALTO PRO" study is a randomized, multicentre, prospective, open-label, superiority trial comparing a personalised versus standard management in patients with MB. Consenting and eligible patients will be randomised 1:1 to either a "full-physiology approach", consisting of a comprehensive diagnostic algorithm aimed at unmasking the main pathophysiological mechanism of myocardial ischemia and consequently a tailored treatment, or a "standard approach", consisting of angiographic evaluation of the tunnelled segment. conditions: Myocardial Bridge studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 500 type: ESTIMATED name: "full-physiology approach" arm name: "standard approach" arm measure: The composite of significant angina and MACE measure: Rate of patients with significant angina (SAQ Angina Summary Score ≤ 70) measure: Incidence of MACE measure: Rate of cardiac death measure: Rate of MI measure: Rate of cardiac hospitalization measure: Rate of TLR sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ospedale Generale Regionale F. Miulli status: NOT_YET_RECRUITING city: Acquaviva Delle Fonti country: Italy lat: 40.89704 lon: 16.8433 facility: Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo status: NOT_YET_RECRUITING city: Alessandria country: Italy lat: 44.90924 lon: 8.61007 facility: Ospedale San Donato status: NOT_YET_RECRUITING city: Arezzo country: Italy lat: 43.46276 lon: 11.88068 facility: ASST Papa Giovanni XXIII status: NOT_YET_RECRUITING city: Bergamo country: Italy lat: 45.69601 lon: 9.66721 facility: Ospedale degli Infermi di Biella status: NOT_YET_RECRUITING city: Biella country: Italy lat: 45.56304 lon: 8.05796 facility: Policlinico S. Orsola IRCCS Azienda Ospedaliero Universitaria status: NOT_YET_RECRUITING city: Bologna country: Italy lat: 44.49381 lon: 11.33875 facility: Azienda Ospedaliera di Rilievo Nazionale Sant'Anna e San Sebastiano status: NOT_YET_RECRUITING city: Caserta country: Italy lat: 41.07262 lon: 14.33231 facility: Villa Maria Cecilia Hospital status: NOT_YET_RECRUITING city: Cotignola country: Italy lat: 44.38572 lon: 11.93852 facility: Azienda Ospedaliero Universitaria di Ferrara status: NOT_YET_RECRUITING city: Ferrara country: Italy lat: 44.83804 lon: 11.62057 facility: Azienda Ospedaliero Universitaria Careggi status: NOT_YET_RECRUITING city: Firenze country: Italy lat: 43.77925 lon: 11.24626 facility: Azienda Ospedaliera Universitaria Policlinico San Martino status: NOT_YET_RECRUITING city: Genova country: Italy lat: 44.40478 lon: 8.94438 facility: Ospedale Della Misericordia status: NOT_YET_RECRUITING city: Grosseto country: Italy lat: 42.76296 lon: 11.10941 facility: Centro Cardiologico Monzino IRCCS status: NOT_YET_RECRUITING city: Milano country: Italy lat: 45.46427 lon: 9.18951 facility: IRCCS Ospedale Galeazzi status: NOT_YET_RECRUITING city: Milano country: Italy lat: 45.46427 lon: 9.18951 facility: Fondazione IRCCS San Gerardo dei Tintori status: NOT_YET_RECRUITING city: Monza country: Italy lat: 45.58005 lon: 9.27246 facility: AOU Maggiore della Carità status: RECRUITING city: Novara zip: 28100 country: Italy name: Domenico D'Amario, Prof role: CONTACT phone: 0039 0321 3733141 email: domenico.damario@uniupo.it name: Domenico D'Amario, Prof role: PRINCIPAL_INVESTIGATOR name: Giuseppe Patti, Prof role: PRINCIPAL_INVESTIGATOR lat: 45.44694 lon: 8.62118 facility: Azienda Ospedaliero Universitaria di Parma status: NOT_YET_RECRUITING city: Parma country: Italy lat: 44.79935 lon: 10.32618 facility: Azienda Ospedaliera di Perugia status: NOT_YET_RECRUITING city: Perugia country: Italy lat: 43.1122 lon: 12.38878 facility: Azienda Ospedaliero Universitaria Pisana status: NOT_YET_RECRUITING city: Pisa country: Italy lat: 43.70853 lon: 10.4036 facility: Ospedale San Jacopo status: NOT_YET_RECRUITING city: Pistoia country: Italy lat: 43.93064 lon: 10.92365 facility: Ospedali Riuniti di Rivoli status: NOT_YET_RECRUITING city: Rivoli country: Italy lat: 45.07073 lon: 7.51465 facility: Aurelia Hospital status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Azienda Ospedaliera San Camillo-Forlanini status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Azienda Ospedaliero Universitaria Sant'Andrea status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS status: RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Ospedale Sandro Pertini status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Ospedale Santo Spirito status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Policlinico Universitario Tor Vergata Fondazione PTV status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Ospedale Civile Santissima Annunziata status: NOT_YET_RECRUITING city: Sassari country: Italy lat: 40.72586 lon: 8.55552 facility: Azienda Sanitaria Provinciale di Siracusa status: NOT_YET_RECRUITING city: Siracusa country: Italy lat: 37.08415 lon: 15.27628 facility: Azienda Ospedaliera Ordine Mauriziano status: NOT_YET_RECRUITING city: Torino country: Italy lat: 45.07049 lon: 7.68682 facility: Azienda Ospedaliero Universitaria Città Della Salute E Scienza status: NOT_YET_RECRUITING city: Torino country: Italy lat: 45.07049 lon: 7.68682 facility: Presidio Ospedaliero Sant'Andrea status: NOT_YET_RECRUITING city: Vercelli country: Italy lat: 45.32163 lon: 8.41989 facility: Azienda Ospedaliera Universitaria Integrata, Ospedale Borgo Trento status: NOT_YET_RECRUITING city: Verona country: Italy lat: 45.4299 lon: 10.98444 hasResults: False