hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06289049 id: HREBA.CC-24-0021 briefTitle: Heavy Strength Training in Head and Neck Cancer Survivors acronym: LIFTING2 overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-01 date: 2026-04 date: 2024-03-01 date: 2024-03-05 name: University of Alberta class: OTHER briefSummary: Despite improvements in treatments, head and neck cancer survivors (HNCS) still endure acute and chronic side effects such as loss of muscular strength, limitations in physical functioning, fatigue, and swallowing difficulties that impact quality of life (QoL) and limit return to work. Light-to-moderate intensity strength training (LMST) has been shown to improve some side effects. Heavy lifting strength training (HLST) may further improve outcomes in some populations, however, only one small pilot study has focused on HNCS. The LIFTING 2 trial will be the first to examine the feasibility and effects of a HLST program versus no exercise in HNCS. conditions: Head and Neck Neoplasms conditions: Head and Neck Cancer conditions: Head and Neck Squamous Cell Carcinoma conditions: Head and Neck Carcinoma studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE maskingDescription: Participants and investigators will not be blinded to group assignment given the nature of the intervention. count: 60 type: ESTIMATED name: Experimental measure: Recruitment rate measure: Adherence to a heavy lifting strength training program measure: Completion of maximal strength testing measure: Followup assessment rate measure: Safety measure: Muscular Strength measure: Cancer Specific Quality of Life measure: Fear of Cancer Recurrence measure: Symptom Burden measure: Perceived Stress measure: Self-Esteem measure: Sleep Habits measure: Malnutrition Status measure: Swallowing Abilities measure: Shoulder Range of Motion measure: Body composition measure: Handgrip Strength measure: Physical Function sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Alberta city: Edmonton state: Alberta country: Canada name: Stephanie Ntoukas role: CONTACT email: ntoukas@ualberta.ca name: Kerry Courneya role: PRINCIPAL_INVESTIGATOR lat: 53.55014 lon: -113.46871 hasResults: False
nctId: NCT06289036 id: H2020206632 briefTitle: Prognosis in Subacute Ischemic Stroke Using Multimodal Imaging overallStatus: COMPLETED date: 2021-02-01 date: 2023-12-31 date: 2023-12-31 date: 2024-03-01 date: 2024-03-01 name: The First Hospital of Hebei Medical University class: OTHER briefSummary: We enrolled patients with subacute IS, associated with moderate-to-severe stenosis of the unilateral cervical internal carotid artery, who underwent 4D ASL. Perfusion levels and collateral circulation were compared between groups with favorable prognosis (modified Rankin scale \[mRS\] ≤ 2) and poor prognosis (mRS \> 2). conditions: The Levels of Cerebral Perfusion and Collateral Circulation in Patients With Subacute Stroke studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 28 type: ACTUAL measure: Modified Rankin Scale（mRS） score after 3 months of onset sex: ALL minimumAge: 18 Years maximumAge: 88 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The First Hospital of Hebei Medical University city: Shijia Zhuang state: Hebei country: China lat: 34.17775 lon: 109.84894 hasResults: False
nctId: NCT06289023 id: NCC1278 briefTitle: HA-WBRT-SIB for Brain Metastasis of Lung Cancer overallStatus: COMPLETED date: 2016-01-01 date: 2020-01-01 date: 2022-12-31 date: 2024-03-01 date: 2024-03-01 name: Cancer Institute and Hospital, Chinese Academy of Medical Sciences class: OTHER briefSummary: Patients with lung cancer and brain metastases undergo HA-WBRT-SIB using image-guided radiotherapy, receiving a total dose of 30-36 Gy delivered in 18-20 fractions to the whole brain (CTV), while the dose to the GTV is boosted to 44 Gy-52 Gy in 18-20 fractions, ﬁve times a week. The optimal mean dose (Dmean) to the bilateral hippocampus should optimally be ≤ 8 Gy, with a mandatory maximum dose (Dmax) to the hippocampus not exceeding 10 Gy; the preferred Dmean to the hippocampus PRV should optimally be ≤ 9 Gy, while the mandatory Dmax to the hippocampus PRV should be ≤ 12 Gy. The HVLT-R immediate recall scores are obtained at baseline and 1, 3, and 6 months after treatment. conditions: Lung Neoplasm conditions: Brain Metastases conditions: Simultaneous Integrated Boost conditions: Hippocampal Avoidance conditions: Cognitive Function studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 40 type: ACTUAL name: HA-WBRT-SIB measure: OS measure: PFS measure: iPFS measure: HVLT-R learning score sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciecnces and Peking Union Medical College city: Beijing state: Beijing country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06289010 id: 7354E briefTitle: Neural Mechanisms of Family-Focused Treatment for Youth Depression overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2027-03 date: 2027-11 date: 2024-03-01 date: 2024-03-04 name: Boston University Charles River Campus class: OTHER name: Massachusetts Institute of Technology briefSummary: The goal of this interventional study is to compare the baseline neural mechanisms and parenting in depressed and non-depressed children and to examine baseline neural mechanisms and parenting as predictors of Family-Focused Treatment for Childhood-Depression (FFT-CD) outcomes. The main questions it aims to answer are:
* complete follow up evaluations and neuroimaging conditions: Childhood Depression studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 80 type: ESTIMATED name: Family-Focused Treatment for Childhood-Depression (FFT-CD) measure: Depression Treatment Response measure: Children's Self Report of Depressive Symptoms measure: Depression Remission sex: ALL minimumAge: 7 Years maximumAge: 12 Years stdAges: CHILD facility: Boston University city: Boston state: Massachusetts zip: 02215 country: United States name: Martha C Tompson, PhD role: CONTACT phone: 617-358-4584 email: mtompson@bu.edu name: Natalie Marr, BS role: CONTACT phone: 6173539610 email: nmarr@bu.edu name: Martha C Tompson, PhD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Athinoula A. Martinos Imaging Center at Massachusetts Institute of Technology city: Charlestown state: Massachusetts zip: 02129 country: United States name: John DE Gabrieli, PhD role: CONTACT phone: 617-253-8946 email: gabrieli@mit.edu name: John DE Gabrieli, PhD role: PRINCIPAL_INVESTIGATOR lat: 42.37787 lon: -71.062 hasResults: False
nctId: NCT06288997 id: TFYuan_tACS briefTitle: tACS Intervention for Methamphetamine Addiction acronym: tACS for MUD overallStatus: COMPLETED date: 2021-11-21 date: 2023-05-09 date: 2023-11-09 date: 2024-03-01 date: 2024-03-01 name: Shanghai Mental Health Center class: OTHER briefSummary: A growing body of evidence suggests a wide range of brain areas are critical for regulating cognitive control over decisions and involving in drug related cue processing. Previous studies have demonstrated that transcranial alternating current stimulation (tACS) over prefrontal cortex reduces craving for meth dependences. In this study, the investigators investigated whether a current level of 15mA with a patented frequency of 77.5Hz tACS intervention of prefrontal cortex cortices in methamphetamine addiction could reduce the subjective craving and improve the cognitive abilities. conditions: Methamphetamine-dependence studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 23 type: ACTUAL name: transcranial alternating current stimulation name: sham tACS measure: Changes of Cue-induced craving measure: Changes of cognition: behavioral inhibition measure: Changes of cognition: choice under ambiguity measure: changes of neural mechanism measure: Changes of depression status measure: Changes of anxiety status measure: Changes of sleep status measure: Changes of impulsivity measure: event-related potential in passive viewing task measure: side effect measurements sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beijing Tiantanghe Addiction Rehab Center city: Beijing state: Beijing zip: 100054 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06288984 id: NFEC-2024-061 briefTitle: Effects of rTMS on Respiratory Function and Gut Microbiota in Patients With Brain Injury overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-06-30 date: 2026-12-31 date: 2024-03-01 date: 2024-03-01 name: Nanfang Hospital, Southern Medical University class: OTHER briefSummary: Impaired respiratory function may occur after brain injury, and will progress to restricted respiratory dysfunction without early intervention. At present, there is a lack of effective treatment options for respiratory dysfunction. Repetitive Transcranial Magnetic Stimulation(rTMS) is a non-invasive, painless and non-invasive neuroregulatory technique. In healthy people, rTMS applied to the respiratory motor cortex induces a contralateral respiratory muscle response. However, whether rTMS can improve respiratory function in patients with brain injury remains unclear. gut microbiota can affect muscle function and mass, and animal experiments have shown that probiotics can increase skeletal muscle mass and grip strength in mice. On the other hand, studies have found that rTMS can improve the nutritional status of patients with vegetative state by regulating the structure of gut microbiota. However, it remains unclear whether rTMS can improve respiratory muscle function in patients with brain injury by regulating gut microbiota. Therefore, the investigators intend to apply rTMS to the respiratory motor cortex to observe whether rTMS can improve respiratory function and reduce the incidence of pneumonia in patients with brain injury, and to observe the role of gut microbiota in this process. conditions: Brain Injuries conditions: Respiratory Function Impaired conditions: Gut Microbiota studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 74 type: ESTIMATED name: active rTMS name: sham rTMS measure: Diaphragm thickness measure: Thickening fraction measure: Diaphragm mobility measure: Surface EMG of diaphragm measure: Forced vital capacity(FVC) measure: Forced expiratory volume at one second（FEV1） measure: Peak expiratory flow (PEF) measure: Maximum voluntary ventilation (MVV) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06288958 id: Fondazione Stella Maris briefTitle: Quality of Life in Children With Cerebral Palsy overallStatus: COMPLETED date: 2019-04-01 date: 2020-12-31 date: 2021-12-31 date: 2024-03-01 date: 2024-03-01 name: IRCCS Fondazione Stella Maris class: OTHER briefSummary: Cerebral Palsy (CP) is an umbrella term that defines a group of permanent disorders of movement and posture, happening during the developing foetal or infant brain. In addition to the main motor symptoms, other clinical disturbances are associated. CP represents a clinical condition with an impact in Quality Of Life (QOL) and social participation, as reported in different countries. QOL is a multidimensional construct defined as "an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards, and concerns" (WHOQOL, 1998).
In order to best capture the peculiarities of CP, specific questionnaires were carried out to analyse the QOL in this clinical population. The Cerebral Palsy Quality of Life Questionnaire for Children (CP QOL-Child) is an internationally recognized CP-specific instrument based on the International Classification of Functioning, Disability and Health (ICF) framework. Many studies have used this instrument, showing a lower QOL in children with CP compared to their typical developing peers. In literature, several studies have shown that children with CP are at risk of experiencing activity limitations and participation restriction and which can potentially affect their QOL. Participation in daily-life activities, defined as a person's "involvement in a life situation," and participation restriction, characterised as "problems an individual may experience in involvement in life situations" (ICF, World Health Organization, 2001). Studies aimed at describing participation in daily-life activities in CP have consistently found lower frequencies and fewer activities in children and adolescents with CP. In order to gain an overall picture of the QOL and participation of children and adolescents with CP, several studies underline the importance of analysing other background factors, such as motor and cognitive functioning, pain perception, and individual characteristics.
The present study aims to deeper understand the perception of QOL and social participation in a group of Italian children with CP, as reported by their parents, using two commonly used questionnaires in the CP population (CP-QOL and PEM-CY). In addition, this study aims to explore the roles of specific clinical variables, such as motor function and cognitive level, on parental perceptions of QOL, in the development of QOL and participation. conditions: Unilateral and Bilateral Cerebral Palsy studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 80 type: ACTUAL name: Quality of Life and social participation in Italian children with CP measure: Score of CP-QOL Child questionnaire measure: Score of PEM-CY questionnaire measure: Scores of Wechsler Intelligence scales sex: ALL minimumAge: 4 Years maximumAge: 12 Years stdAges: CHILD facility: IRCCS Fondazione Stella Maris city: Pisa zip: 56128 country: Italy lat: 43.70853 lon: 10.4036 hasResults: False
nctId: NCT06288945 id: Dry eye syndrome briefTitle: Effect of an Educational Program on Health-related Outcomes of Patients With Dry Eye Syndrome overallStatus: COMPLETED date: 2023-01-15 date: 2023-09-14 date: 2023-09-14 date: 2024-03-01 date: 2024-03-01 name: Alexandria University class: OTHER briefSummary: Dry eye syndrome (DES) is a widespread ocular disease affecting the general population. It is a complex disorder affecting the surface of the eye, marked by an imbalance in the tear film and ocular symptoms. Therefore this study was done to determine the effect of an educational program on health-related outcomes of patients with DES including the severity of symptoms related to DES and their influence on visual-related functions conditions: Dry Eye Syndrome studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ACTUAL name: Educational Program measure: ocular irritation symptoms associated with Dry eye syndrome and their effect on functions related to vision sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Faculty of Nursing, Alexandria university city: Alexandria country: Egypt lat: 31.21564 lon: 29.95527 hasResults: False
nctId: NCT06288932 id: NIBD/IRB-263/08-2023 briefTitle: Outcome Study of Conventional Steroids vs. Steroids Combined With Mycopehnolate in Newly Diagnosed Immune Thrombocytopenia Purpura. overallStatus: RECRUITING date: 2024-02 date: 2024-05 date: 2025-01 date: 2024-03-01 date: 2024-03-01 name: National Institute of Blood and Marrow Transplant (NIBMT), Pakistan class: OTHER_GOV briefSummary: Immune thrombocytopenia Purpura (ITP) is an autoimmune condition delineated by humoral as well as cell mediated immune response against thrombocyte surface proteins GPIIb/IIIa receptors, affecting primary homeostasis leading to mucocutaneous bleeding.ITP is characterized by platelet count \<100 x 109/L. The conventional line of treatment for newly diagnosed ITP is steroids but significant disadvantages have been associated with long term use and a high risk of relapse when reducing the dose. The addition of MMF to the first line treatment of ITP resulted in substantial response and a lower risk of refractory ITP with decreased financial burden and improved outcome. conditions: Immune Thrombocytopenia Purpura studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study will comprise the newly diagnosed patients of Immune thrombocytopenia purpura aged 5-60 year. Patients will be included in this trial, with a 1:1 ratio among the two group patients will be in each group. One group will receive steroids alone and the other will receive steroids and MMF. primaryPurpose: TREATMENT masking: NONE count: 104 type: ESTIMATED name: Mycophenolate Mofetil (MMF) Treatment measure: Platelet count monitoring measure: Assessment of Health-Related Quality of Life questionnaire measure: Incidence of adverse events sex: ALL minimumAge: 5 Years maximumAge: 60 Years stdAges: CHILD stdAges: ADULT facility: National Institute of Blood Diseases and Bone Marrow Transplantation status: RECRUITING city: Karachi state: Sindh zip: 75300 country: Pakistan lat: 24.8608 lon: 67.0104 hasResults: False
nctId: NCT06288919 id: 2023-IMPLHYGIENE briefTitle: Erythritol vs Ultrasonic Scaler Prophylaxis Systems on Dental Implants With Crowns Made by Different Materials overallStatus: ENROLLING_BY_INVITATION date: 2024-03-01 date: 2026-04-01 date: 2026-04-10 date: 2024-03-01 date: 2024-04-26 name: University of Pavia class: OTHER briefSummary: The aim of the study is to assess which prophylaxis methods is the most suitable for peri-implant hygiene between erythritol and ultrasonic scaler with peek inserts.
The oral hygiene session will be carried out every 6 months (2-years follow-up; 6 sessions), after instruction and motivation of the patient, completion of the clinical chart with the recording of the Probing Depth (evaluation in mm of the peri-implant sulcus taken by a periodontal probe; 4 surfaces of the gingival margin are detected: vestibular, palatal/lingual, mesial, distal), Bleeding on Probing and Plaque Index. conditions: Dental Implant Failed conditions: Peri-implant Mucositis conditions: Peri-Implantitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Erythritol prophylactic powders name: Ultrasonic scaler with peek inserts measure: Probing Depth (PD) measure: Bleeding on Probing (BoP) measure: Plaque Index sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Unit of Dental Hygiene - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Paediatrics - University of Pavia city: Pavia state: Lombardy zip: 27100 country: Italy lat: 45.19205 lon: 9.15917 hasResults: False
nctId: NCT06288906 id: ASTER Study briefTitle: Acute and Subacute Iliofemoral and/or Caval Deep Vein Thrombosis: Evaluation of Mechanical Thrombectomy Systems acronym: ASTER overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2027-03 date: 2027-12 date: 2024-03-01 date: 2024-03-04 name: IRCCS San Raffaele class: OTHER briefSummary: This is a physician-initiated, observational, monocentric, retrospective and prospective Study. The study is intended to assess the feasibility of mechanical thrombectomy of caval and iliofemoral veins according to normal clinical practice in adult patients with symptomatic acute or subacute ileofemoral or caval deep vein thrombosis objectively diagnosed with CT scan imaging. conditions: Thrombosis, Venous studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 50 type: ESTIMATED name: mechanical thrombectomy of caval and iliofemoral veins measure: Rate of Technical success measure: Number of Participants presenting Bleeding sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: San Raffaele Hospital city: Milano zip: 20132 country: Italy lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06288893 id: DEU-2001 briefTitle: SHEN211 Tablets for the Treatment of Mild and Moderate Novel Corona Virus Infections (COVID-19) overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-08-01 date: 2025-01-01 date: 2024-03-01 date: 2024-03-04 name: JKT Biopharma Co., Ltd. class: INDUSTRY briefSummary: Randomized, double-blind, placebo-controlled, multicenter phase II clinical study of SHEN211 tablets conditions: COVID-19 studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized 2:1 to experimental and placebo arms primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: double-blind whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: SHEN211 Tablets name: Placebo for SHEN211 Tablets measure: Change from baseline in SARS-CoV-2 viral load at each time point measure: Time of recovery measure: Time to response measure: Time to negative measure: Percentage of subjects with disappearance of clinical symptoms measure: Change in COVID-19 symptom score measure: Ct value change from baseline measure: Change from baseline in chest CT scan (optional) measure: Percentage of Subjects Progressed measure: Percent of Subjects Who Died measure: Safety Assessment Results sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shenzhen Third People 's Hospital city: Shenzhen state: Guangdong zip: 518112 country: China name: Hongzhou Lu, ph.D role: CONTACT phone: 0755-61232898 email: luhongzhou@fudan.edu.cn name: Ximin Meng role: CONTACT phone: 0755-61222333 phoneExt: 16565 email: szywjd2015@163.com name: Hongzhou Lu, ph.D role: PRINCIPAL_INVESTIGATOR lat: 22.54554 lon: 114.0683 hasResults: False