hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06308133 id: CD34+CE_2023 briefTitle: Biological Variables Affecting CD34+ Peripheral Cells Collection Efficiency acronym: CD34+CE_2023 overallStatus: COMPLETED date: 2023-09-01 date: 2023-12-01 date: 2023-12-31 date: 2024-03-13 date: 2024-03-13 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico class: OTHER briefSummary: All procedures performed during the study will comply with current clinical practice, international and national guidelines. Main object of the study is the PBSC apheresis procedure performed by using the continuous mononuclear cells collection (cMNC) system with Spectra Optia (Terumo BCT), specifically the biological and clinical factors affecting the procedure efficiency. conditions: Optimize PBSC Harvest Through Automated Buffy Coat studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 113 type: ACTUAL name: apheresis procedure measure: measured by statistical correlation measure: Correlation of clinical sex: ALL minimumAge: 16 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Istituto di Ricovero e Cura a Carattere Scientifico di natura pubblica city: Milan state: Milano zip: 20122 country: Italy lat: 45.46427 lon: 9.18951 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-07-10 uploadDate: 2024-03-06T12:44 filename: Prot_SAP_000.pdf size: 378344 hasResults: False
nctId: NCT06308120 id: ISI-IONCN-002 briefTitle: A Trial to Compare Robotic Assisted Bronchoscopy Ion's Clinical Utility for Peripheral Lung Nodule Access and Diagnosis to ENB acronym: ARTICULAtE overallStatus: RECRUITING date: 2024-03-20 date: 2026-06-30 date: 2026-09-30 date: 2024-03-13 date: 2024-04-03 name: Intuitive Surgical class: INDUSTRY name: Intuitive Surgical-Fosun Medical Technology (Shanghai) Co., Ltd briefSummary: Multi-center randomized controlled study designed to compare the diagnostic yield of ION™ Endoluminal System with electromagnetic navigation bronchoscopy in patients undergoing transbronchial sampling procedure of peripheral pulmonary nodules. conditions: Pulmonary Nodule, Solitary conditions: Lung Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Stratified, randomized controlled trial with parallel group assignment primaryPurpose: DIAGNOSTIC masking: SINGLE maskingDescription: Pathologist reviewing biopsy results will be blinded whoMasked: OUTCOMES_ASSESSOR count: 354 type: ESTIMATED name: Ion Endoluminal System name: superDimension Navigation System and Accessories measure: Diagnostic Yield measure: Sensitivity for malignancy of biopsy obtained samples measure: Incidence of pneumothorax that requires chest tube placement and/or re-hospitalization or extended hospitalization measure: Incidence of intraoperative severe airway bleeding sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai Chest Hospital status: RECRUITING city: Shanghai state: Shanghai country: China name: Jiyuan Sun, M.D. role: CONTACT name: Jiyuan Sun, M.D. role: PRINCIPAL_INVESTIGATOR lat: 31.22222 lon: 121.45806 facility: Zhongshan Hospital status: NOT_YET_RECRUITING city: Shanghai state: Shanghai country: China name: Yuanlin Song, M.D. role: CONTACT name: Yuanlin Song, M.D. role: PRINCIPAL_INVESTIGATOR lat: 31.22222 lon: 121.45806 facility: West China Hospital status: NOT_YET_RECRUITING city: Chengdu state: Sichuan country: China name: Dan Liu role: CONTACT name: Dan Liu, M.D. role: PRINCIPAL_INVESTIGATOR lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06308107 id: IRB00433127 briefTitle: Safety and Feasibility of Hyperkalemic Cardioplegia With Diazoxide in Cardiac Surgery (CPG-DZX) Trial overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-04-30 date: 2028-04-30 date: 2024-03-13 date: 2024-03-13 name: Johns Hopkins University class: OTHER briefSummary: This study aims to confirm the safety and efficacy of diazoxide as an additive to hyperkalemic cardioplegia in patients undergoing cardiac surgery with cardiopulmonary bypass. The investigators hypothesize that diazoxide combined with hyperkalemic cardioplegia provides superior myocardial protection and reduced myocardial stunning compared with standard cardioplegia alone. Thirty patients will receive treatment. Safety will be assessed by comparing mean arterial blood pressure measurements, glucose levels and incidence of adverse events between the two groups. Efficacy will be assessed by comparing right and left ventricular function in pre-operative vs post-operative transesophageal echocardiograms, need for mechanical circulatory support, ease of separation from bypass and Vasoactive Inotrope Score (VIS) between the two groups. The information gained could pave the way for the use of Katp (Potassium-atp) channel openers to prevent stunning, improve patient outcomes, and reduce health care costs related to myocardial stunning that requires inotropic and mechanical support following cardiac surgery. conditions: Myocardial Stunning studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 30 type: ESTIMATED name: IV Diazoxide measure: Safety as assessed by mean change in blood pressure measure: Safety as assessed by change in blood glucose levels measure: Safety as assessed by incidence of adverse events measure: Efficacy as assessed by change in ejection fraction measure: Efficacy as assessed by use of mechanical circulatory support measure: Efficacy as assessed by change in Vasoactive Inotropic Score (VIS) measure: Efficacy as assessed by time to separate from Cardiopulmonary Bypass (CPB) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Johns Hopkins Hospital city: Baltimore state: Maryland zip: 21287 country: United States lat: 39.29038 lon: -76.61219 hasResults: False
nctId: NCT06308094 id: IRB00429859 briefTitle: 320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation. overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-04-01 date: 2025-04-01 date: 2024-03-13 date: 2024-04-26 name: Johns Hopkins University class: OTHER briefSummary: This study explores the relationship between myocardial fibrosis and patient outcomes in Atrial Fibrillation (AF), specifically after catheter ablation. It aims to use Cardiac CT, an accessible tool, to measure left ventricular extracellular volume (ECV) as an indicator of fibrosis. The study will assess if higher ECV levels correlate with increased risks of AF recurrence, hospitalization, and poor cardiac function recovery. Positive findings could make ECV a key factor in deciding AF treatment strategies. conditions: Atrial Fibrillation studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE maskingDescription: Two independent blinded trained readers will detect, interpret and quantify interstitial fibrosis using CT images, to ascertain intra- and inter-observer variability. The readers will determine the region of interest (ROI), myocardial and blood pool attenuation values in the pre-contrast and 5 minutes delayed acquisition. count: 100 type: ESTIMATED name: CT measure: Recurrence of Atrial Fibrillation measure: Occurrence of ER visits, hospitalizations for cardiovascular causes measure: Change in Ejection Fraction measure: Quality of Life as assessed by the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06308068 id: BE24-002 briefTitle: Bioequivalence Study of Diacerein 50 mg Capsule in Healthy Thai Volunteers overallStatus: NOT_YET_RECRUITING date: 2024-07-30 date: 2024-08-03 date: 2024-08-18 date: 2024-03-13 date: 2024-03-13 name: International Bio service class: NETWORK briefSummary: To determine and compare the rate and extent of absorption of a test formulation with that of a reference innovator formulation when given as equal labeled dose in healthy subjects under fed conditions conditions: Healthy Volunteer studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: NONE count: 30 type: ESTIMATED name: Diacerein 50 mg Capsule measure: Bioequivalence based on Cmax period measure: Bioequivalence based on AUC parameters sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT hasResults: False
nctId: NCT06308055 id: 2022-R01 briefTitle: Abiomed Impella RT-DAQ - Observational Study overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-04-01 date: 2024-03-13 date: 2024-03-13 name: Abiomed Inc. class: INDUSTRY briefSummary: Abiomed IMPELLA-RT-DAQ - Impella Real Time Data AcQuisition conditions: Cardiogenic Shock studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 125 type: ESTIMATED name: Data Acquisition measure: Collection of hemodynamic parameters (Cardiac Output in l/min) measure: Collection of hemodynamic parameters (Blood Pressure in mmHg, Pulmonary Artery Pressure in mmHg, Central Venous Pressure in mmHg, Pulmonary Capillary Wedge Pressure in mmHg) measure: Collection of hemodynamic parameters (Mixed Venous Saturation in %) measure: Collection of hemodynamic parameters (Pulmonary Vascular Resistance in In dynes/sec/cm-5 ) measure: Rate of Patient Survival sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06308042 id: 2024/5558 briefTitle: Remote Evaluation in Patients With Multiple Sclerosis overallStatus: NOT_YET_RECRUITING date: 2024-03-11 date: 2024-06-24 date: 2024-06-29 date: 2024-03-13 date: 2024-03-13 name: Inonu University class: OTHER briefSummary: This study aimed to demonstrate the remote reliability of the 30-second sit-to-stand test in patients with multiple sclerosis. conditions: Multiple Sclerosis studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 10 type: ESTIMATED name: 30 second sit and stand test measure: 30 second sit and stand test sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06308029 id: Edge003203 id: T001122N type: OTHER_GRANT domain: Research Foundations Flanders id: s68058 type: OTHER domain: UZ/KU Leuven ID briefTitle: Effectiveness of an eHealth Self-management Support Program for Persistent Pain After Breast Cancer Treatment acronym: PECAN overallStatus: RECRUITING date: 2024-04-12 date: 2027-03-20 date: 2028-03-20 date: 2024-03-13 date: 2024-04-15 name: Universiteit Antwerpen class: OTHER name: Universitaire Ziekenhuizen KU Leuven name: University Ghent name: KU Leuven name: University Hospital, Antwerp briefSummary: The scientific goals of the project are:
* To examine the implementation process, mechanisms of impact and contextual factors. conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Pragmatic randomized, multi-centric, three-arm controlled trial primaryPurpose: TREATMENT masking: NONE count: 270 type: ESTIMATED name: eHealth self-management support program name: Face-to-face rehabilitation program measure: Pain-related disability measure: Pain related disability measure: Pain severity measure: Severity of neuropathic Pain measure: Medication use measure: Pain location measure: Knowledge of neurophysiology of pain measure: Physical Activity pattern measure: Physical functioning measure: Fatigue measure: Sleep disturbance measure: Pain Beliefs measure: Pain-related worrying measure: Vigilance to bodily sensations measure: Depression measure: Anxiety measure: Determinants for physical activity measure: Participation measure: Well-being measure: Social Support measure: Return to work rate measure: Medical costs of medical consumption measure: Indirect costs related to disease outside health care measure: Health-related quality of life measure: Patient Global Impression of Change sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Universiteit Antwerpen status: RECRUITING city: Antwerpen country: Belgium name: An De Groef, PhD role: CONTACT email: an.degroef@uantwerpen.be name: Lore Dams, PhD role: CONTACT email: lore.dams@uantwerpen.be lat: 51.21989 lon: 4.40346 facility: KU Leuven status: RECRUITING city: Leuven country: Belgium name: Nele Devoogdt, PhD role: CONTACT email: nele.devoogdt@kuleuven.be name: An De Groef, PhD role: CONTACT email: an.degroef@kuleuven.be lat: 50.87959 lon: 4.70093 hasResults: False
nctId: NCT06308016 id: 25/IRE/23 briefTitle: Study of the Risk of Pharyngocutaneous Fistula in a Population of Patients Undergoing Total Laryngectomy and Creation of a Score for Pre-operative Risk Stratification. overallStatus: RECRUITING date: 2023-12-01 date: 2024-12-01 date: 2024-12-01 date: 2024-03-13 date: 2024-03-13 name: Regina Elena Cancer Institute class: OTHER briefSummary: Multicenter retrospective study of a cohort of patients affected by laryngeal carcinoma and subjected to total laryngectomy surgery at the centers participating in the reference period and responding to inclusion criteria. conditions: Laryngeal Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 500 type: ESTIMATED measure: Identification of risk factors measure: Stratify patients sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: "Regina Elena" National Cancer Institute status: RECRUITING city: Rome zip: 00144 country: Italy name: Raul Pellini, MD role: CONTACT phone: ND email: raul.pellini@ifo.it name: Francesco Mazzola, Doctor role: CONTACT phone: 06 5266 4485 email: francesco.mazzola@ifo.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06308003 id: PTA CONF briefTitle: Effect of Surgical Approach on Postoperative Bleeding in Patien Arthroplasty overallStatus: RECRUITING date: 2023-02-13 date: 2025-04 date: 2025-09 date: 2024-03-13 date: 2024-03-13 name: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio class: OTHER briefSummary: The study is, in accordance with current legislation, definable as monocentric Prospective Observational.
Preoperative T0: clinical visit/medical history, completion of the VAS questionnaire, Blood sampling to assess hemoglobin values Operative T1: hip arthroplasty surgery using one of the surgical approaches routinely used within our Institute T2 - Postoperative at 1 day from T1: VAS questionnaire, evaluation of any Adverse events T3 - Postoperative at 3 days from T1: blood loss based on the values of hemoglobin (Hb), assessment of any adverse events, and VAS questionnaire T4- Post operative at 45 days +/- 10 days from T1: evaluation of any events adverse, follow-up visit. conditions: Hip Arthropathy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: Anterior hip arthroplasty measure: The primary outcome will be blood loss calculated on the basis of hemoglobin (Hb) on the third postoperative day. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istituto Clinico San Siro status: RECRUITING city: Milan country: Italy name: Elena Cittera role: CONTACT phone: 0283502224 email: elena.cittera@grupposandonato.it name: Alberto Ventura role: PRINCIPAL_INVESTIGATOR lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06307990 id: 05M202 briefTitle: Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects acronym: ADAM-THAD overallStatus: RECRUITING date: 2023-01-01 date: 2024-12-31 date: 2025-04-30 date: 2024-03-13 date: 2024-03-13 name: Istituto Auxologico Italiano class: OTHER name: ASST Fatebenefratelli Sacco name: Federico II University briefSummary: The goal of this observational study is to learn about the neurological and cardiological phenotype of patients with resistance to thyroid hormone (RTH) syndromes beta and alpha (RTHß and RTHa) due to dominant negative variants in the genes encoding the thyroid hormone receptors alpha (THRA) and beta (THRB).
Participants, recruited at neonatal screening or from cohorts of patients with unexplained specific neuro-cognitive or cardiovascular phenotypes will be submitted to biochemical and genetic investigations. In addition pluripotent stem cells will be generated from peripheral blood cells of RTHs patients and studied in vitro to understand the molecular mechanisms underlying neurological and cardiovascular consequences. In vitro and clinical data, will be correlated to identify biomarkers for monitoring treatment. conditions: Resistance, Thyroid Hormone studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 150 type: ESTIMATED name: NGS sequencing name: serological tests measure: to define the frequency and improve early diagnosis for RTH syndromes. measure: to demonstrate that zebrafish zygotes are useful for screening of the pathogenicity of new TR mutations measure: Direct differentiation of THRA mutant patients-derived human induced pluripotent stem cells (hiPSCs) to neural progenitors (hiPSc-CNeu) and cardiomyocyte (hiPSC-CMs) measure: To identify TH-target genes involved in determining stemness, proliferation potential and differentiation of hiPSC measure: to define the prevalence of RTH syndromes in specific cohorts of patients with unexplained phenotypes measure: Generation of a comprehensive RTH database sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Istituto Auxologico Italiano IRCCS status: RECRUITING city: Milan zip: 20145 country: Italy name: Irene Campi, MD, PhD role: CONTACT lat: 45.46427 lon: 9.18951 facility: Department of Endocrine & Metabolic Diseases, San Luca Hospital status: RECRUITING city: Milan country: Italy name: Luca Persani, Prof role: CONTACT lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06307977 id: R01DA059272 type: NIH link: https://reporter.nih.gov/quickSearch/R01DA059272 briefTitle: Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples acronym: CHP overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2028-01 date: 2029-02 date: 2024-03-13 date: 2024-04-08 name: Hunter College of City University of New York class: OTHER name: National Institute on Drug Abuse (NIDA) briefSummary: This study utilizes a randomized controlled trial design to evaluate the efficacy of couples motivational interviewing (MI) to reduce the frequency and severity of illicit drug use and frequency of HIV transmission risk behavior (TRB). Participants are randomized to one of two conditions: couples MI or standard couples HIV testing and counseling (CHTC). conditions: Substance Use conditions: HIV Infections studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL interventionModelDescription: This study utilizes a randomized controlled trial design to evaluate the efficacy of couples motivational interviewing (MI) to reduce the frequency and severity of illicit drug use and frequency of HIV transmission risk behavior (TRB). Participants are randomized to one of two conditions: couples MI or standard couples HIV testing and counseling (CHTC). primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 360 type: ESTIMATED name: Couples Health Project measure: Drug use Frequency measure: Urine assay for drug use measure: CAS with casual partners measure: Bacterial sexually transmitted infections measure: Binge Drinking measure: PrEP Uptake sex: MALE minimumAge: 18 Years maximumAge: 34 Years stdAges: ADULT facility: Wayne State University city: Detroit state: Michigan zip: 48201 country: United States name: Angulique Outlaw, PHD role: CONTACT email: aoutlaw@med.wayne.edu lat: 42.33143 lon: -83.04575 facility: Hunter College city: New York state: New York zip: 10018 country: United States lat: 40.71427 lon: -74.00597 facility: University of Virginia city: Charlottesville state: Virginia zip: 22904 country: United States name: Karen Ingersoll role: CONTACT email: kes7a@virginia.edu lat: 38.02931 lon: -78.47668 hasResults: False
nctId: NCT06307964 id: 69HCL23_1137 id: ID-RCB type: OTHER domain: 2024-A00480-47 briefTitle: Intra-Hepatic Microbiota in Alcoholic Hepatitis acronym: HepMAH overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-01 date: 2026-07 date: 2024-03-13 date: 2024-03-13 name: Hospices Civils de Lyon class: OTHER briefSummary: Alcoholic hepatitis (AH) is a serious complication of alcoholic liver disease (ALD). The histological presentation of AH is characterized by neutrophilic lobular inflammation, macrovesicular steatosis, hepatocyte ballooning and necrosis and the presence of Mallory bodies. In cases of severe HA, defined by a modified Maddrey score of 32 or above, mortality at 1 month is estimated at between 10 and 50%. The only treatment to reduce early mortality is corticosteroid therapy. However, only 60% of patients respond to corticosteroids, and no benefit has been demonstrated on late mortality. Identifying new therapeutic targets is therefore a major challenge in this disease.
The aim of this study is to determine the composition of the intrahepatic (obtained from transjugular liver biopsy), blood and fecal microbiota in patients with suspected severe AH from a monocentric prospective cohort in the Hepatology Department at Croix-Rousse Hospital (Lyon). Fifty consecutive patients with clinical suspicion of AH and indication for transjugular liver biopsy will be included. About thirty-five patients are expected in the confirmed AH group, and 15 in the group "alcoholic liver disease with no AH", based on data from the literature. The composition of the various microbiota will be determined by sequencing the 16S rRNA gene, and the results will be correlated with clinical data (corticosteroid sensitivity, overall survival, transplant-free survival, MELD score in particular) and histological data.
This exploratory study will enable to analyze the intra-hepatic microbiota, and to study its link with intra-hepatic inflammation and the clinical course of patients with AH. The data generated by HepMAH will thus help identify potential new therapeutic targets linked to the gut microbiota, and provide a scientific basis for the development of therapeutic interventions targeting the microbiota in HA. conditions: Cirrhosis conditions: Alcoholic Liver Disease conditions: Alcoholic Hepatitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: Biological sampling measure: Microbiota composition sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06307951 id: JCDC/BHR/24/012 briefTitle: Exploration of Infant and Young Child Feeding Practices and Their Determinants overallStatus: RECRUITING date: 2023-04-25 date: 2025-11-30 date: 2025-11-30 date: 2024-03-13 date: 2024-03-13 name: Hirabai Cowasji Jehangir Medical Research Institute class: OTHER briefSummary: The goal of this observational study is to assess infant and young child-feeding practices among women living in urban areas and slums in Pune and rural areas around Pune, India, and to investigate the reasons for the adopted infant and young child-feeding practices in Slum-dwelling women aged 18 to 49 years who have an infant/s less than 24 months of age.