hackint0sh/New-Dataset huggingface dataset:
After an up to 28-day screening period, eligible participants will be randomized in a 2:1 ratio to receive efgartigimod PH20 SC or placebo PH20 SC, respectively. Study drug will be administered subcutaneously during the 24-week double-blinded treatment period (DBTP). At the end of the DBTP (week 24), proptosis responders will enter a follow-up observational period (52 weeks) to assess the safety, tolerability, and durability of efgartigimod PH20 SC treatment while off therapy. Proptosis nonresponders and participants who have proptosis relapse during the 52-week follow-up observational period will receive open-label treatment with efgartigimod PH20 SC for up to 24 weeks. conditions: Thyroid Eye Disease studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 108 type: ESTIMATED name: Efgartigimod PH20 SC name: Placebo PH20 SC measure: Percentage of participants who were proptosis responders measure: Change in proptosis measurement in the study eye from baseline measure: Change in the total Graves' Orbitopathy Quality of Life (GO-QoL) score from baseline measure: Percentage of participants with a resolution of diplopia (responders) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Advanced Clinical Research status: RECRUITING city: Coral Springs state: Florida zip: 33067 country: United States name: Shailesh Gupta, MD role: CONTACT phone: 857-350-4834 email: clinicaltrials@argenx.com lat: 26.27119 lon: -80.2706 hasResults: False
nctId: NCT06307600 id: BHCT-RD06-03 briefTitle: The Safety and Efficacy of RD06-03 CART Cell Injection in Patients With R/R Acute B-lymphoblastic Leukemia overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2025-03-15 date: 2027-04-01 date: 2024-03-13 date: 2024-03-13 name: Anhui Provincial Hospital class: OTHER_GOV briefSummary: This study is designed to explore the safety and efficacy for patients with relapsed and/or refractory B-cell lymphoblastic leukemia. conditions: B Lymphoblastic Leukemia/Lymphoma studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 9 type: ESTIMATED name: RD06-03 cell injection measure: Dose-limiting toxicity sex: ALL minimumAge: 3 Years maximumAge: 70 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Anhui Provincial Hospital city: Hefei state: Anhui zip: 230036 country: China lat: 31.86389 lon: 117.28083 hasResults: False
nctId: NCT06307587 id: 2023/2355 briefTitle: Vastus Intermedius Dry Needling for Knee Stiffness Resulted From Surgically Managed Femoral Fractures With Open Reduction & Internal Fixation. overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-03-01 date: 2027-03-12 date: 2024-03-13 date: 2024-03-13 name: Al-Razi Hospital class: OTHER_GOV briefSummary: Orthopedic traumatic injuries are considered a major health epidemic, challenged by high morbidity, mortality, and socioeconomic burden. The management of traumatic orthopedic injuries is challenging and complex, with high resources utilization. Particularly, the prevalence of femoral fractures in Kuwait is 8.8%, being one of the most prevalent injuries. Open reduction and internal fixation (ORIF) is a common surgical procedure for the management of femoral fractures demonstrating successful outcome for allowing minimally invasive percutaneous plate osteosynthesis, early union of 93% to 100%, and low infection rate of only 0% to 2%. Yet, one of the major complications post ORIF is knee stiffness and reduced function, which brings many inconveniences to patients' daily lives, lead to disability, and could seriously threaten the functional activities of patients. The incidence of knee stiffness requiring surgical intervention is 14.5%. Particularly, the potential loss of knee flexion is 30 to 40 degrees, 13% of the patients failed to reach 90 degrees of knee flexion, and only 48% of patients reached \>120 degrees of flexion. Ultimately, knee stiffness in flexion forms a major issue in distal femoral fractures. Various reasons could explain such complication including intrinsic adhesions, fibrosis and shortening of the vastus intermedius muscle.
There are various surgical procedures which could be used to manage knee stiffness. However, there is no consensus regarding the ideal approach and strategy with many postoperative complications including deep sepsis, quadricep tendon rupture, skin dehiscence and infection, delayed wound healing, patella fracture, lateral femoral condyle fracture and extension lag. In contrast, dry needling (DN) is a minimal invasive intervention for the management of musculoskeletal dysfunction, and it could be used to reduce the adhesion and fibrosis between the vastus intermedius and the femoral bone. However, there is limited research investigating the effect of DN on the vastus intermedius muscle after ORIF of the femoral fractures. The effectiveness of DN was explored for the management of various musculoskeletal conditions, and a systematic review addressing DN in the lower quarter concluded that DN is an effective procedure (Morihisa et a,., 2016). In ACL reconstruction, DN for the vastus medialis improved ROM at short-term and improved function at both short and long term. DN has been proposed as a useful addition to the rehabilitation of ACL reconstructed in reducing pain intensity, increasing knee flexion range, and modifying the mechanical properties of the quadriceps muscle during the late-stage of rehabilitation. DN has also altered the passive mechanical properties of the quadriceps muscle where decrement and resistance of the vastus medialis were significantly reduced. It is hypothesized that releasing the adhesions and fibrosis of the vastus intermedius could play an important role in managing knee stiffness post ORIF of the distal femur fractures. Therefore, the aim of this project is to identify the incidence rate and risk factors of knee stiffness resulted from surgically managed femoral fractures with open reduction and internal fixation in Kuwait, and to investigate the effect of DN on the vastus intermedius muscle in improving knee joint range of motion and function after ORIF of the distal femur using single blind randomized controlled trial (RCT). conditions: Femur Fracture studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 44 type: ESTIMATED name: dry needling measure: knee flexion range of motion sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT hasResults: False
nctId: NCT06307561 id: GGurzoglu briefTitle: The Effect of Dystonia Severity on Participation in Daily Living Activities and Caregivers in Children of Cerebral Palsy With Secondary Dystonia overallStatus: COMPLETED date: 2021-01-01 date: 2024-01-01 date: 2024-01-01 date: 2024-03-13 date: 2024-03-13 name: Acıbadem Atunizade Hospital class: OTHER briefSummary: Dystonia is the most common movement disorder in the pediatric population after spasticity. It can affect normal motor development and cause significant motor retardation. The presence of dystonia may affect motor function, pain, and ease of care in CP. Additionally, it can cause serious difficulties in daily living activities and social participation and long-term joint deformity. The increase in the severity of dystonia in CP children with secondary dystonia may affect the quality of life, activity and participation of the children, as well as the caregiver. The importance of caregivers is an undeniable fact, especially in these patient groups. This study aims to investigate the burden of dystonia severity on the participation in daily living activities and caregivers of children with CP with secondary dystonia. conditions: Secondary Dystonia conditions: Cerebral Palsy, Mixed studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 20 type: ACTUAL measure: The Barry-Albright Dystonia Scale (BADS) measure: The Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD) measure: The Care and Comfort Hypertonicity Questionnaire (CCHQ) sex: ALL minimumAge: 3 Years maximumAge: 15 Years stdAges: CHILD facility: Acıbadem Altunizade Hospital city: Istanbul state: Altunizade zip: 34662 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06307535 id: 23-376 briefTitle: A Study of Meaning-Centered Psychotherapy for Caregivers to People With Cancer overallStatus: RECRUITING date: 2024-02-29 date: 2029-03-01 date: 2029-03-01 date: 2024-03-13 date: 2024-04-11 name: Memorial Sloan Kettering Cancer Center class: OTHER briefSummary: Participants will complete 1 set of questionnaires about 2 weeks before beginning their Meaning-Centered Psychotherapy for Caregivers/MCP-C or standard Supportive Psychotherapy for Caregivers/SP-C sessions. These questionnaires will ask about participants' sense of meaning and purpose in life, spiritual well-being, depression and/or anxiety, and social support. Participants will then be assigned to receive either MCP-C or SP-C for 7 sessions. Participants will complete additional sets of questionnaires about 2 weeks, 6 months, and 12 months after their last session of MCP-C or SP-C. It will take between 35 and 50 minutes to complete each set of questionnaires.
Participants may remain in the study and continue to receive all 7 sessions of MCP-C or SP-C even if their loved one passes away. conditions: Caregiver Burden conditions: Caregiver Burnout conditions: Caregiver Stress Syndrome studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 200 type: ESTIMATED name: Meaning-Centered Psychotherapy for Caregivers name: Supportive Psychotherapy for Caregivers measure: Number of participants with improved primary outcomes sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Miami (Data Collection AND Data Analysis) status: NOT_YET_RECRUITING city: Miami state: Florida zip: 33136 country: United States name: Wendy Lichtenthal, PhD role: CONTACT phone: 305-243-8983 lat: 25.77427 lon: -80.19366 facility: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) status: RECRUITING city: Basking Ridge state: New Jersey zip: 07920 country: United States name: Allison Applebaum, PhD role: CONTACT phone: 646-888-0034 lat: 40.70621 lon: -74.54932 facility: Memorial Sloan Kettering Monmouth (Limited protocol activities) status: RECRUITING city: Middletown state: New Jersey zip: 07748 country: United States name: Allison Applebaum, PhD role: CONTACT phone: 646-888-0034 lat: 40.39652 lon: -74.09211 facility: Memorial Sloan Kettering Bergen (Limited Protocol Activities) status: RECRUITING city: Montvale state: New Jersey zip: 07645 country: United States name: Allison Applebaum, PhD role: CONTACT phone: 646-888-0034 lat: 41.04676 lon: -74.02292 facility: Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity) status: RECRUITING city: Commack state: New York zip: 11725 country: United States name: Allison Applebaum, PhD role: CONTACT phone: 646-888-0034 lat: 40.84288 lon: -73.29289 facility: Memorial Sloan Kettering Westchester (Consent only) status: RECRUITING city: Harrison state: New York zip: 10604 country: United States name: Allison Applebaum, PhD role: CONTACT phone: 646-888-0034 lat: 40.96899 lon: -73.71263 facility: Memorial Sloan Kettering Cancer Center status: RECRUITING city: New York state: New York zip: 10065 country: United States name: Allison Applebaum, PhD role: CONTACT phone: 646-888-0034 lat: 40.71427 lon: -74.00597 facility: Memorial Sloan Kettering Nassau (Limited Protocol Activites) status: RECRUITING city: Rockville Centre state: New York zip: 11553 country: United States name: Allison Applebaum, PhD role: CONTACT phone: 646-888-0034 lat: 40.65871 lon: -73.64124 hasResults: False
nctId: NCT06307522 id: MRG24ALC briefTitle: MRG-001 in Patients With Alcoholic Hepatitis overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2026-09-01 date: 2026-12-01 date: 2024-03-13 date: 2024-03-13 name: MedRegen LLC class: INDUSTRY briefSummary: The goal of this study is to test MRG-001 (an experimental medication). The purpose of this trial is to assess the dose related safety, Pharmacokinetics, and Pharmacodynamics of MRG-001 in patients with severe alcoholic hepatitis (AH). conditions: Alcoholic Hepatitis conditions: Acute Alcoholic Hepatitis studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 32 type: ESTIMATED name: MRG-001 measure: Assessment of Treatment-Emergent Adverse Events measure: Pharmacokinetic Response measure: Pharmacodynamic Response sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06307509 id: GN23AN097 briefTitle: Adiposity and Immunometabolism in Sepsis acronym: AIMS overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-04-30 date: 2025-07-31 date: 2024-03-13 date: 2024-03-13 name: NHS Greater Glasgow and Clyde class: OTHER name: University of Glasgow briefSummary: Obesity has been shown to increase adverse outcomes in some critically ill patients e.g. those with COVID-19. For patients with sepsis this association is less clear cut but there is evidence that body fat distribution, resulting from impaired subcutaneous adipose tissue function, is associated with adverse clinical outcomes in critical care. The investigators aim to study subcutaneous adipose tissue function in lean and obese sepsis patients in critical care and compare that to healthy controls.
The aim is to better understand the relationship between obesity, inflammation, mitochondrial dysfunction and sepsis. The investigators hope that this may improve the understanding of the pathophysiology of sepsis and allow more targeted interventions for patients based on differences in their baseline metabolic state. conditions: Obesity conditions: Sepsis studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: Diagnosis of sepsis measure: Difference in adipocyte cytokine secretion between patients with sepsis, and patients without sepsis, and between SAT and VAT samples measure: Differences in adipocyte size measure: Differences in mitochondrial morphology measure: Differences in adipocyte pro-inflammatory gene expression measure: Differences in adipocyte mitochondrial number measure: Differences in adipocyte mitochondrial viability measure: Differences in SVF cytokine secretion measure: Differences in capacity of pre-adipocytes to differentiate into mature adipocytes sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Critical Care Medicine, Queen Elizabeth University Hospital city: Glasgow zip: G51 4TF country: United Kingdom lat: 55.86515 lon: -4.25763 hasResults: False
nctId: NCT06307496 id: Pro00133913 briefTitle: VIDeOS for Smoking Cessation overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-04 date: 2025-07 date: 2024-03-12 date: 2024-03-12 name: Medical University of South Carolina class: OTHER name: Alliance NCORP Research Base Cancer Control Program briefSummary: The purpose of the current study is to pilot the efficacy, feasibility, and acceptability of an evidence-based smoking cessation intervention adapted for cancer patients and delivered via video. Investigators aim to assess if this intervention is considered acceptable by participants, feasible to implement, and effective at increasing knowledge about smoking cessation before conducting a fully powered clinical trial. conditions: Cancer conditions: Smoking Cessation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 40 type: ESTIMATED name: Smoking cessation intervention name: Informational intervention measure: Acceptability measure: Feasibility measure: Retention Rates measure: Changes in knowledge about quitting smoking measure: Changes in smoking behaviors sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06307483 id: 20240108 briefTitle: Dose-effect Relationship of Tai Chi on Health Promotion in Different Age Groups overallStatus: COMPLETED date: 2023-08-25 date: 2023-11-25 date: 2023-11-25 date: 2024-03-12 date: 2024-03-26 name: Beijing Sport University class: OTHER briefSummary: The purpose of this study is to investigate the physical and mental health status of middle-aged and elderly people of different ages and practicing Tai chi for different periods of time, so as to provide a strong theoretical basis and practical guidance for delaying age-related aging and preventing and treating the occurrence and development of chronic diseases. conditions: Sleep Disorder conditions: Cardiovascular Diseases conditions: Hypertension conditions: Cognitive Impairment conditions: Metabolic Disease studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 499 type: ACTUAL name: Taichi group name: Exercise group measure: Pittsburgh Sleep Quality Index measure: Heart rate variability (HRV) measure: Flow-mediated dilation (FMD) measure: Cardiac Output (CO) measure: Intima-Media Thickness (IMT) measure: The Berg Balance Scale（BBS） measure: The 30-s Chair Stand Test measure: Lower limb muscle strength test measure: Body Fat Percentage measure: Finger-Ring Test measure: Hand Grip Strength measure: Upper and Lower Body Flexibility measure: The SARC-F scale measure: Shape Trail Test (STT) measure: 1-back Task more-odd shifting Task Stroop Task measure: Timed Up and Go measure: Close-eyed stepping in place measure: Single-leg stance with eyes closed measure: Ankle-Brachial Index (ABI) measure: Short-Physical Performance Battery (SPPB) measure: Hospital Anxiety and Depression Scale (HADS) measure: Blood pressure variability (BPV) measure: HUR Labs Balance Software Suite measure: E/A ratio measure: Star Excursion Balance Test apparatus（SEBT） measure: Montreal Cognitive Assessment(MoCA) measure: Brachial-ankle pulse wave velocity (BaPWV) sex: ALL minimumAge: 20 Years maximumAge: 79 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beijing Sport University city: Beijing country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06307470 id: 276879 briefTitle: Nurse-led Mind-body Intervention on Sexual Health for Breast Cancer Survivors overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-05-30 date: 2024-05-30 date: 2024-03-12 date: 2024-03-20 name: University of Arkansas class: OTHER name: Intimate Pathways Center for Sexual Health briefSummary: The goal of this clinical trial is to test the efficacy of a nurse-led psychoeducational sexual health intervention for young women breast cancer survivors. The main questions it aims to answer are:
Participants will participate in a nurse-led psychoeducational intervention for 8 sessions lasting approximately an hour each over the course of 8 - 10 weeks. Each participant will complete survey items at the beginning, end, and six-weeks after the last session. Participants will be compensated up to $150 in gift cards as a thank-you for their time. conditions: Women's Health: Neoplasm of Breast conditions: Menopause, Premature conditions: Body Image conditions: Sexual Dysfunction conditions: Cancer, Breast studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 42 type: ESTIMATED name: EMBRACE (Empowerment through Mind and Body Reclamation After Cancer Experience) measure: Vulvovaginal Symptoms Questionnaire (VSQ) measure: Body Image Scale measure: Female Sexual Functioning Index sex: FEMALE minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT hasResults: False
nctId: NCT06307457 id: A5481188 briefTitle: A Study of HR+/HER2- Metastatic Breast Cancer Patients Treated With Palbociclib Together With an Aromatase Inhibitor From 2017 to 2023 in Denmark. overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-06 date: 2024-08-31 date: 2024-08-31 date: 2024-03-12 date: 2024-03-27 name: Pfizer class: INDUSTRY briefSummary: The purpose of this study is to describe the effect of the medicine palbociclib when given together with an aromatase inhibitor for treatment of breast cancer. The study will consider participants who:
* Human epidermal growth factor receptor 2 negative (HER2-): cells that have a small amount or none of a protein called HER2 on their surface. In normal cells, HER2 helps control cell growth. Cancer cells that are HER2 negative may grow more slowly and are less likely to recur (come back) or spread to other parts of the body than cancer cells that have a large amount of HER2 on their surface. Checking to see if a cancer is HER2 negative may help plan treatment.
nctId: NCT06307444 id: stellate block and ESP block briefTitle: Ultrasound-Guided Erectro Spinae Plane Block Versus Stellate Ganglion Block for Patients With Upper Limb Acute Herpes Zoster Pain. overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-10-01 date: 2024-11-01 date: 2024-03-12 date: 2024-03-12 name: Tanta University class: OTHER briefSummary: Herpes zoster (HZ) is a painful, eruptive, viral condition results from reactivation of the latent varicella zoster virus after the primary infection. The selection of an effective analgesic method in the acute phase of herpes zoster can decrease the incidence of postherpetic neuralgia by reducing neural sensitization. The stellate ganglion is present in 80% of the general population and is composed of the inferior cervical ganglion and the first thoracic ganglion fusion. It lies anterior to the neck of the first rib and extends to the inferior aspect of the transverse process of C7. The erector spinae plane (ESP) block has been reported to provide diffuse and effective analgesia in the cervical, thoracic, and lumbar regions. conditions: Acute Herpes Zoster Pain Managment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 93 type: ESTIMATED name: Ultrasound-Guided Stellate Ganglion Block name: T2 T3 (High Thorathic) ESP Block measure: reduction of a numeric rating scale (NRS) pain score sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False