hackint0sh/New-Dataset huggingface dataset:
Participants will receive 1 intramuscular injection of PHV01 or placebo on Day 1 and will be followed for 181 days. conditions: Marburg Virus Disease studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: PREVENTION masking: QUADRUPLE maskingDescription: Single-blind whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 36 type: ESTIMATED name: PHV01 name: Placebo measure: Solicited Adverse Events (AEs) measure: Unsolicited AEs measure: Other AEs measure: Immunogenicity, Antibodies (Ab) measure: Immunogenicity, Neutralizing antibodies (NEUT) sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: CenExel RCA status: RECRUITING city: Hollywood state: Florida zip: 33024 country: United States name: Terry Piedra role: CONTACT phone: 305-596-3125 email: t.piedra@cenexel.com name: Amanda Gonzalez role: CONTACT phone: 813-817-7984 email: amanda.gonzalez@cenexel.com name: Craig Shapiro, MD role: PRINCIPAL_INVESTIGATOR lat: 26.0112 lon: -80.14949 hasResults: False
nctId: NCT06264999 id: 427976 briefTitle: Robotic Assisted Knee Arthroplasty - Retain the Anterior Cruciate Ligament or Not overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-04 date: 2026-04 date: 2024-02-20 date: 2024-02-23 name: St. Olavs Hospital class: OTHER name: Smith & Nephew, Inc. briefSummary: The goal of this clinical trial is to compare the function of the knee after retaining or sacrificing the anterior cruciate ligament in robotic assisted knee arthroplasty.
* CT based Micromotion analysis of the implant micromovement conditions: Arthritis Knee conditions: Arthroplasty conditions: Gait Analysis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Journey II CR name: Journey II XR measure: Preferred walking speed (meter/minute) after surgery measure: CT-RSA measured maximum total point of motion(MTPM) measure: evaluation of max walking speed(m/minute) measure: stride length(cm) measure: step length in mid stance phase (cm) measure: single leg support time(s) measure: double-leg support time(s) measure: stair performance(s) measure: Rating pain using NRS (Numeric Rating Scale). measure: KOOS-PS (Knee Injury and Osteoarthritis Outcome score) measure: Clinical evaluation of range of motion . measure: Rating outcome using EQ-5D-5L(European quality of life index version 5D-5L), measure: IKSS (International Knee Society System knee and function score) measure: FJS-12 (Forgotten Joint score) measure: Clinical evaluation of Anteroposterior stability. measure: Clinical evaluation of Mediolateral stability. measure: A long leg X-Ray identifying outliers with Hip Knee Ankle angle Varus <-3 ºor Valgus >3 º measure: Presence of eminence fractures sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: St.Olavs Hospital city: Trondheim state: Trøndelag zip: 7006 country: Norway name: Anders Sjøstrøm, MD role: CONTACT phone: +4772575241 email: anders.sjostrom@stolav.no name: Siri Bjørgen Winther, PhD role: SUB_INVESTIGATOR name: Sølvi Liabekk Selli role: SUB_INVESTIGATOR lat: 63.43049 lon: 10.39506 hasResults: False
nctId: NCT06264986 id: 2023-09-02 briefTitle: The Effects of Ashwagandha (Withania Somnifera) Supplementation on Exercise Performance in Female Footballers overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-13 date: 2024-02-21 date: 2024-02-21 date: 2024-02-20 date: 2024-02-20 name: Blanca Roman-Viñas, MD class: OTHER briefSummary: The goal of this clinical trial is to evaluate the effects of short-term root extract ashwagandha supplementation on exercise performance in female footballers. The main question it aims to answer are:
Participants will either supplement 600mg (5% withanolides) root extract ashwagandha or placebo once a day for 28 days. There will be three data points: baseline, 14 days and 28 days. Researchers will compare values of intervention against placebo to see if there is an effect on muscle strength or perception of recovery. conditions: Muscle Strength studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Double-blind, placebo-controlled, randomised trial primaryPurpose: BASIC_SCIENCE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 30 type: ACTUAL name: Ashwagandha name: Placebo measure: Increased lower body muscle strength measure: Increased maximum voluntary muscle strength measure: Increased upper body muscle strength and explosiveness measure: Improved overall muscle strength measure: Improved perception of wellbeing measure: Improved perception of recovery sex: FEMALE minimumAge: 17 Years maximumAge: 40 Years stdAges: CHILD stdAges: ADULT facility: Club Esportiu Seagull city: Badalona state: Barcelona zip: 08917 country: Spain lat: 41.45004 lon: 2.24741 hasResults: False
nctId: NCT06264973 id: NL9318 briefTitle: Maternal and Fetal/Neonatal Pharmacokinetics and - Dynamics of Corticosteroids During Pregnancy acronym: MaDyCo overallStatus: RECRUITING date: 2021-01-01 date: 2025-06-01 date: 2025-12-01 date: 2024-02-20 date: 2024-02-20 name: Erasmus Medical Center class: OTHER briefSummary: Improving pregnancy outcome is essential in improving health of both parents and their offspring during the life course. Preterm birth (PTB) occurs in 10-15% of all pregnancies, is the leading cause of perinatal mortality and morbidity {Goldenberg, 2008}, has long-term adverse consequences for postnatal health {Huddy, 2001} and is a burden for health care expenditure. In order to improve neonatal outcome, antenatal corticosteroids (ACS) are routinely administered to women at risk for preterm delivery before 34 weeks of pregnancy. {Jobe, 2018;Roberts, 2017;Travers, 2018} However, the current, worldwide standard of care, for the use of ACS is still based on animal experiments performed in the 1970's. {Liggins, 1969} Although ACS treatment to improve neonatal outcome was clinically introduced in the 70's, still only two dosing regimens are used, neither of which have been investigated, re-evaluated or refined to determine the optimal doses or treatment interval. With the current health care approach of personalized medicine in mind, the same universal approach for everybody, independent of gestational age, number of fetus, maternal weight or comorbidity one dose does not fit all since it often has not the desired effect. Due to the lack of optimization of the above mentioned synthetic corticosteroid drug regimens {Kemp, 2019}, significant gaps in knowledge exist. An important aspect to set up, investigate and understand dosing and also dosing interval experiments, is knowledge of the maternal individual pharmacokinetics and pharmacogenetics of the drug of interest during pregnancy. conditions: Preterm Birth studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED measure: Pharmacokinetics of antenatal corticosteroids by investigation of betamethasone concentrations in serum measure: Maternal age measure: Fetal sex measure: Maternal weight/BMI measure: Number of fetus measure: Parity: the number of times a woman has given birth to a live neonate (any gestation) or at 24 weeks or more measure: PE by urine measurement of protein-creatinine ratio measure: Oestradiol concentration in serum measure: Cord blood and neonatal blood measure: CYP3A4 level sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Erasmus Medical Center status: RECRUITING city: Rotterdam state: Zuid Holland zip: 3015GD country: Netherlands name: Sam Schoenmakers, MD, PhD role: CONTACT phone: +31107037439 email: s.schoenmakers@erasmusmc.nl name: Emma Ronde-Salminen, MD role: CONTACT phone: 0031683997312 email: e.ronde@erasmusmc.nl lat: 51.9225 lon: 4.47917 hasResults: False
nctId: NCT06264960 id: E10208771 briefTitle: The Effect of Music Therapy and Breathing Exercise on Anxiety and Pain in Patients Undergoing Coronary Angiography overallStatus: COMPLETED date: 2022-09-15 date: 2023-05-30 date: 2023-10-02 date: 2024-02-20 date: 2024-02-20 name: Ulku Gunes class: OTHER briefSummary: Coronary angiography serves as the primary diagnostic technique for cardiovascular disease. However, this invasive procedure commonly triggers pain, anxiety, and fear in patients. The objective of this randomized controlled trial was to examine the impact of music and breathing exercises on anxiety and pain levels in individuals undergoing coronary angiography. The study, conducted as a single-blind, randomized controlled trial, involved a sample of 165 patients, with 55 in each group: the control group, the breathing exercise group, and the music therapy group. Patients in the music group listened to music during angiography, those in the breathing exercise group practiced exercises 30 minutes before the procedure, while the control group received standard treatment. Anxiety levels were assessed both before and after the procedure, and pain levels were measured post-procedure. The study strictly adhered to the CONSORT statement guidelines. conditions: Procedural Pain conditions: Procedural Anxiety studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: This single-center, single-blind, randomized controlled trial was conducted in Izmir, Turkey, from July 2021 to July 2022. Participants were randomly assigned to one of three groups: intervention 1 (music), intervention 2 (breathing exercises), or control (standard care), in a 1:1:1 ratio. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The nurse responsible for conducting all measurements, including pain and anxiety assessments using the Visual Analog Scale (VAS) and State-Trait Anxiety Inventory (STAI), was not part of the research team.
The nurse, being independent and not aware of the participants' group assignments, helps to ensure that the assessments are conducted impartially, without knowledge of which intervention each participant received. whoMasked: OUTCOMES_ASSESSOR count: 512 type: ACTUAL name: Music therapy name: Breathing exercise measure: State-Trait Anxiety Inventory measure: Visual Analog Scale sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ege University city: Bornova state: İzmir zip: 35100 country: Turkey lat: 38.47921 lon: 27.2399 facility: Ülkü Güneş city: Bornova state: İzmir zip: 35100 country: Turkey lat: 38.47921 lon: 27.2399 hasResults: False
nctId: NCT06264947 id: CMUH112-REC2-141 briefTitle: Efficacy of Laser Acupuncture on Zanzhu (BL02) for Dry Age-related Macular Degeneration overallStatus: ENROLLING_BY_INVITATION date: 2024-01-26 date: 2024-11-01 date: 2024-11-01 date: 2024-02-20 date: 2024-02-20 name: China Medical University Hospital class: OTHER briefSummary: This study is to see if laser acupuncture is a better way to treat dry-AMD (Age-related Macular Degeneration) compared to sham laser acupuncture, in the aspect of visual acuity. Investigators planed to recruit participants who are diagnosed with dry-AMD, and not younger than 20 years old. Before the study, investigators will measure the participants' BCVA (Best Corrected Visual Acuity), and then practice laser acupuncture and sham-laser acupuncture on experiment group and control group respectively. After the 4-week study, investigators will measure the participants' BCVA again. conditions: Age-related Macular Degeneration studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: laser acupuncture name: sham laser acupuncture measure: BCVA (Best Corrected Visual Acuity) sex: ALL minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT facility: China Medical University Hospital city: Taichung zip: 404 country: Taiwan lat: 24.1469 lon: 120.6839 hasResults: False
nctId: NCT06264934 id: DiCECT briefTitle: An Investigation Into Dielectric Assessment of Permittivity and Cancer in Human Using a Novel Electrical Capacitance Tomography Scanner acronym: DiCECT overallStatus: RECRUITING date: 2024-01-25 date: 2024-12 date: 2024-12 date: 2024-02-20 date: 2024-02-23 name: Zedsen Limited class: INDUSTRY name: Imperial College Healthcare NHS Trust briefSummary: The goal of this observational study is to investigate the ability of a the Z-scanner to identify and differentiate cancer and benign lesions from healthy breast tissue based on permittivity. The main questions it aims to answer are:
2. Determine the repeatability, reproducibility, inter-and intra-operator variability of the Z-scanner. conditions: Breast Cancer conditions: Benign Breast Disease studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 90 type: ESTIMATED name: Breast scan using the Z-scanner name: Breast scan using the Z-scanner measure: Measurement of complex permittivity of breast tissue components measure: Permittivity target-to-background contrast ratios for targets of interest (e.g. malignant lesion, benign lesion) measure: Repeatability of the Z-scanner measure: Reproducibility of the Z-scanner sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Imperial College Healthcare NHS Trust status: RECRUITING city: London country: United Kingdom name: Lesley Honeyfield role: CONTACT name: Adrian Lim role: PRINCIPAL_INVESTIGATOR name: Deborah Cunningham role: SUB_INVESTIGATOR name: Sylvie Flais role: SUB_INVESTIGATOR lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06264908 id: 20240125-010-000 briefTitle: An Integrated Self Management Programme to Improve Outcomes in Patients With Hand Osteoarthritis acronym: OASIS-H overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-12 date: 2028-04 date: 2024-02-20 date: 2024-02-20 name: Dr Iris Tang Yan Ki class: OTHER name: Hospital Authority, Hong Kong briefSummary: The goal of this trial is to evaluate the efficacy of an integrated self-management programme in improving clinical outcomes in patients with hand osteoarthritis (OA).
Participants will be randomized into early intervention group and routine clinical care groups in a 1:1 ratio. Patients who randomized into early intervention group will receive 8 week integrated self-management programme delivered by occupational therapists and rheumatology nurse on hand OA management. Patients who randomized into routine clinical care group will receive usual clinical care for OA for 26 weeks and then receive an identical 8 weeks integrated self-management programme. The primary outcome is the improvement in pain at 26 weeks between the two groups. conditions: Hand Osteoarthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Patients will be randomized into early intervention and routine clinical care (control) group. Patients in control group will crossover to receive the intervention at week 26. primaryPurpose: TREATMENT masking: NONE count: 90 type: ESTIMATED name: Integrated self-management programme measure: Change in Pain visual analogue scale (VAS) measure: Change in pain Visual Analogue Scale (VAS) measure: Change in Functional index hand osteoarthritis (FIHOA) measure: Change in Quick Disabilities of the Arm, Shoulder, and Hand (DASH) score measure: Change in Australian/Canadian Hand Osteoarthritis Index (AUSCAN) 3.1 measure: Change in Short-form 36 items health survey measure: Change in hand grip strength measure: Change in hand dexterity measurement measure: Radiographic changes measure: Adverse events measure: Use of rescue pain medication sex: ALL minimumAge: 40 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06264895 id: Trinity College Dublin 211202 briefTitle: Protocol for a Low Threshold Exercise Intervention for Women Experiencing Homelessness and Addiction. acronym: LEAP-W overallStatus: NOT_YET_RECRUITING date: 2024-02-26 date: 2024-07-31 date: 2024-07-31 date: 2024-02-20 date: 2024-02-20 name: University of Dublin, Trinity College class: OTHER briefSummary: Background: Frailty is a complex multi-dimensional state of increased vulnerability to adverse health outcomes and is usually associated with older age but there is growing evidence of accelerated ageing and frailty in non-geriatric populations, including those experiencing socio-economic deprivation and extreme social exclusion, such as people experiencing homelessness. Addiction, as a coping mechanism for prior trauma, is common among people who are homeless and can have a gendered dimension. Women experiencing homelessness and addiction have unique needs which require a gendered approach. The aim of this study is to explore the effectiveness of an exercise intervention to target the known physical functioning deficits and frailty which this population experiences.
Methods: This mixed-methods study will explore physical functioning deficits and frailty in women experiencing homelessness and addiction, using a bespoke test battery and an exercise intervention. Physical function (10m Walk Test, 2 Minute Walk Test, Single Leg Stance Test, Chair Stand Test, hand grip dynamometry), frailty (Clinical Frailty Scale and the SHARE-FI) and nutritional status (Mini-Nutritional Status), pain (Numerical Pain Rating Scale) and quality of life (SF 12-V2) will be evaluated. The intervention will involve a 3-times weekly exercise programme with protein supplementation for 10 weeks. Following this, qualitative interviews, which will be thematically analysed using Braun \& Clarke methodology, will be conducted. This study will be conducted in Dublin from February to July 2024.
Discussion: Little is kn own about frailty-focussed interventions in women experiencing homelessness and addiction. This proposed study will help to increase the knowledge base regarding the physical health burden and frailty experienced by this extremely vulnerable population and will deliver a targeted intervention with a gendered dimension to mitigate its affects. The findings of this research will help narrow this research gap and will guide clinicians and policy makers to implement unique gender-based treatment strategies for this population. conditions: Social Exclusion conditions: Chronic Disease conditions: Physical Disability conditions: Addiction studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: single -arm longitudinal cohort study primaryPurpose: TREATMENT masking: NONE count: 45 type: ESTIMATED name: Exercise measure: Recruitment measure: Retention measure: Adverse events measure: Hand grip dynamometry measure: Limb circumference measure: 10 Metre Walk Test measure: 2 Minute Walk Test measure: The Chair Stand Test measure: Single Leg Stance Test measure: Numerical Rating Scale (NRS) measure: Clinical Frailty Scale (CFS) measure: SHARE-Frailty Instrument (FI) measure: Mini Nutritional Assessment (MNA) measure: Short Form-12 V2 sex: FEMALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06264869 id: 141123 briefTitle: Interdental Guided Creeping Technique overallStatus: NOT_YET_RECRUITING date: 2024-02 date: 2024-11 date: 2024-11 date: 2024-02-20 date: 2024-02-20 name: October 6 University class: OTHER briefSummary: The aim of this randomized clinical trial is to treat interdental papillary deficiency with minimally invasive interdental guided creeping technique (IGCT) comparing collagen membrane versus connective tissue graft. conditions: Interdental Papilla Recession studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: Interdental guided creeping technique (IGCT) and connective tissue graft (CTG) name: Interdental guided creeping technique (IGCT) and collagen membrane (CM) measure: Black triangle height measure: Percentage of interdental papillary fill measure: Papillary gain, black triangle reduction measure: Papillary height, attached gingiva width measure: Pocket depth, clinical attachment level, keratinized tissue thickness measure: Plaque index measure: Gingival index measure: Duration of surgery measure: Patient Reported Outcome measure: Patient Reported Outcome sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT hasResults: False
nctId: NCT06264856 id: 202210096RIND briefTitle: Bronchoscopy for Thoracic Trauma Patients overallStatus: SUSPENDED date: 2024-12-01 date: 2025-12-31 date: 2025-12-31 date: 2024-02-20 date: 2024-02-20 name: National Taiwan University Hospital class: OTHER briefSummary: The study aims to evaluate the effectiveness of bronchoscopic sputum suction in patients with severe thoracic illness-induced respiratory failure. The study will compare the outcomes of patients who receive bronchoscopic sputum suction versus blind negative pressure aspiration for sputum removal. The study will measure baseline data, postoperative blood gas conditions, and clinical parameters, such as time of invasive ventilation, total time of ventilation, hospital stay, weaning success rate, reintubation rate, ventilator-associated pneumonia incidence, and fatality rate. The study aims to determine whether bronchoscopy-assisted sputum removal is superior to blind negative pressure aspiration in improving patient outcomes. conditions: Chest Trauma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: bronchoscopic sputum suction name: negative pressure aspiration suction measure: Rate of pneumonia measure: Intensive Care Unit admission interval measure: admission interval measure: tracheostomy rate measure: intubation rate sex: ALL minimumAge: 20 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Traumatology, National Taiwain University Hospital city: Taipei zip: 10002 country: Taiwan lat: 25.04776 lon: 121.53185 facility: NTUH Hsin-Chu Branch; NTUH Yun-Lin Branch city: Taipei zip: 100; 300; 640; 280 country: Taiwan lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06264843 id: 724 briefTitle: Peripheral Bypass Trial for Completion Control acronym: PATENT overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2027-12 date: 2027-12 date: 2024-02-20 date: 2024-02-20 name: Medistim ASA class: INDUSTRY briefSummary: The goal of the study is to identify and validate flow measurement and ultrasound images in patients undergoing vein bypass surgery below-knee and above ankle conditions: Chronic Limb-Threatening Ischemia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 450 type: ESTIMATED name: Medistim MiraQ system with TTFM and L15 HFUS probes measure: Primary graft patency rate sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False