hackint0sh/New-Dataset huggingface dataset:
• \[Observing the effectiveness and safety of the combination of Adebrelimab and TP regimen in neoadjuvant therapy for clinical IVB stage oral squamous cell carcinoma patients\] Participants will \[Received treatment with Adebrelimab combined with TP regimen, followed by surgery after 2 cycles of neoadjuvant therapy. After surgery, radiotherapy and chemotherapy combined with immunotherapy were chosen based on the patient\'s condition, with a total follow-up of two years.\]. conditions: Clinical IVb Stage Oral Squamous Cell Carcinomas Patients studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 35 type: ESTIMATED name: Adebrelimab measure: Effective mitigation rate（EMR） measure: DFS measure: R0 resection rate measure: ORR measure: mOS sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: School of Stomatology Wuhan University status: RECRUITING city: Hubei state: Wuhan zip: 430079 country: China name: JJia Associate Professor role: CONTACT phone: +8613277924848 email: junjia@whu.edu.cn name: zili Yu role: PRINCIPAL_INVESTIGATOR hasResults: False
nctId: NCT06277778 id: HSEARS20211117003-03 briefTitle: Effect of Combined Music and Taekwondo Training for Children With Autism Spectrum Disorder overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-06-30 date: 2026-12-31 date: 2024-02-26 date: 2024-02-26 name: The Hong Kong Polytechnic University class: OTHER briefSummary: The goal of this randomized controlled trial is to evaluate the effect of combined music and taekwondo training on the mental and physical condition of children with autism spectrum disorder. Participants will be asked to do combined music and taekwondo training or taekwondo training alone to evaluate if the combined training is better than the taekwondo training alone on mental and physical performance for children with autism spectrum disorder. conditions: Autism Spectrum Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 70 type: ESTIMATED name: Taekwondo training with music therapy name: Taekwondo training alone measure: Engagement in the Training Sessions measure: Gross Motor Skills measure: Physical Activity Level measure: Enjoyment State measure: Rate of Perceived Exertion measure: Taekwondo skills performance measure: Conners' Continuous Performance Test II measure: Comprehensive Trail-Making Test (CTMT) measure: Social Responsiveness Scale, second edition (SRS-2) measure: Childhood Autism Spectrum Test measure: Strength and Difficulties Questionnaires (SDQ) measure: Clinical Global Improvement (CGI) score sex: ALL minimumAge: 7 Years maximumAge: 9 Years stdAges: CHILD hasResults: False
nctId: NCT06277765 id: CM310-101212 briefTitle: Study of CM310 Injection in Adolescent Subjects With Atopic Dermatis overallStatus: NOT_YET_RECRUITING date: 2024-05-30 date: 2025-05-30 date: 2025-05-30 date: 2024-02-26 date: 2024-02-26 name: Keymed Biosciences Co.Ltd class: INDUSTRY briefSummary: This is a multi-center, randomized, double blind, placebo-controlled phase 3 study to evaluate the efficacy, safety, PK, PD and immunogenicity of CM310 in children patients with moderate-to-severe atopic dermatitis. conditions: Atopic Dermatitis studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 180 type: ESTIMATED name: CM310 name: placebo measure: Proportion of subjects achieving EASI-75 at week 18 sex: ALL minimumAge: 12 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Peking University People's hospital city: Beijing country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06277752 id: CIBI128A101 briefTitle: A Study to Investigate the Pharmacokinetic/Pharmacodynamic Characteristics of IBI128(A New Xanthine Oxidase Inhibitor) overallStatus: COMPLETED date: 2024-03-05 date: 2024-03-16 date: 2024-03-16 date: 2024-02-26 date: 2024-03-22 name: Innovent Biologics (Suzhou) Co. Ltd. class: INDUSTRY briefSummary: A Phase I study to evaluate the pharmacokinetic/pharmacodynamic characteristics,safety and tolerability of IBI128 after multidosing in Chinese health subjects. conditions: Gout Arthritis studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ACTUAL name: dose-5 group name: dose-1 group name: dose-2 group name: dose-4 group name: dose-3 group measure: PK parameter: Cmax measure: PK parameter: AUC measure: PK parameter: Tmax measure: PK parameter: T1/2 measure: Safety parameter: AE measure: PD parameter: serum UA (uric acid） measure: Tolerability parameter: SAE sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: The First Affiliated city: Zhengzhou state: Henan zip: 450000 country: China lat: 34.75778 lon: 113.64861 hasResults: False
nctId: NCT06277739 id: 20220117020315695 briefTitle: Brain Effect Mechanism of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI overallStatus: ACTIVE_NOT_RECRUITING date: 2022-06-01 date: 2026-09-01 date: 2026-09-01 date: 2024-02-26 date: 2024-02-28 name: Zhou Xingchen class: OTHER briefSummary: The clinical symptoms of Lumbar Disc Herniation (LDH) can be effectively ameliorated through Spinal Manipulative Therapy (SMT), which is closely linked to the brain's pain-regulating mechanisms. Magnetic Resonance Imaging (MRI) offers an objective and visual means to study how the brain orchestrates the characteristics of analgesic effects. From the perspective of multimodal MRI, the investigators applied functional MRI (fMRI) and Magnetic Resonance Spectrum (MRS) techniques to comprehensively evaluate the characteristics of the effects of SMT on the brain region of LDH from the aspects of brain structure, brain function and brain metabolism. This multimodal MRI technique provides a biological basis for the clinical application of SMT in LDH. conditions: Lumbar Disc Herniation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: Spinal Manipulative Therapy name: Sham Laser Treatment measure: visual analogue scale (VAS) measure: Japanese Orthopaedic Association Scores (JOA) measure: Amplitude of Low-Frequency Fluctuation (ALFF) measure: Regional Homogeneity (ReHo) measure: Functional Connectivity (FC) measure: Magnetic Resonance Spectrum （MRS） sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Third Affiliated Hospital of Zhejiang Chinese Medical University city: Hangzhou state: Zhejiang zip: 310053 country: China lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06277726 id: IU-SBE-CGI-01 briefTitle: The Effect of Two Non-pharmacological Methods on Pain and Anxiety Experienced During Intrauterine Device Application. overallStatus: RECRUITING date: 2023-07-01 date: 2024-04 date: 2024-04 date: 2024-02-26 date: 2024-02-26 name: Inonu University class: OTHER name: The Scientific and Technological Research Council of Turkey briefSummary: The purpose of this study is to determine the effect of emotional freedom technique and music, which are effective in relieving pain and anxiety, on the pain and anxiety that occur during intrauterine device application. conditions: Intrauterine Devices studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized controlled study with pre-test post-test group primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: In order to ensure randomization and prevent contamination between groups, data will be collected in a sequence such that emotional freedom technique is collected one week, music is collected one week, and control group data is collected one week. It will be decided by drawing lots which group's data will be collected first. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 168 type: ESTIMATED name: Emotional freedom technique group name: Music group name: Control group measure: Visual Analog Scale (VAS) measure: State Anxiety Inventory sex: FEMALE minimumAge: 18 Years maximumAge: 49 Years stdAges: ADULT facility: Şırnak State Hospital status: RECRUITING city: Şırnak zip: 73000 country: Turkey name: Ceylan GÜZEL İNAL, Lecturer role: CONTACT phone: +095432588644 email: cylngzl@hotmail.com lat: 37.51393 lon: 42.45432 hasResults: False
nctId: NCT06277713 id: CME2023/069 briefTitle: Preventing Exercise Resistance With Sedentary Interruptions acronym: PERSI overallStatus: RECRUITING date: 2024-02-19 date: 2024-10-30 date: 2025-07-01 date: 2024-02-26 date: 2024-03-04 name: Hasselt University class: OTHER briefSummary: The goal of this randomised cross-over trial is to learn about the interaction between sedentary behaviour throughout the day and the metabolic effect of an exercise bout on that same day in office workers with an increased risk for chronic disease.
* Attend three assessment days at the research facility where postprandial metabolism will be evaluated after a standardised meal test. conditions: Sedentary Behavior conditions: Lipid Metabolism Disorder conditions: Exercise studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Participants will follow three regimes of 2 days each including a sedentary control, a sedentary with exercise and a standing breaks with exercise regimen. The sequence of the regimens will be randomised. Each regimen will be followed by a minimum wash-out period of 7 days during which subjects will continue their normal lifestyle.
We will use a balanced design with 6 randomisation blocks (ABC, ACB, BAC,BCA, CAB, CBA). The randomisation will be computer-generated and allocation will be determined by a member of the research team drawing a sealed, non-translucent envelop with herein written the scheme. primaryPurpose: PREVENTION masking: SINGLE maskingDescription: The outcome assessor will be blinded to the allocation of participants as samples will be code labeled. whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: Standing interruptions name: Exercise bout name: Sedentary measure: Total and incremental area under the curve of postprandial response in lipid metabolism measure: Total and incremental area under the curve of glucose and insulin postprandial responses measure: Resting metabolic rate sex: ALL minimumAge: 30 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hasselt University status: RECRUITING city: Diepenbeek state: Limburg zip: 3590 country: Belgium name: Bert Op 't Eijnde, Prof. dr. role: CONTACT phone: +3211292121 email: bert.opteijnde@uhasselt.be name: Jen Vanherle, Drs. role: CONTACT email: jen.vanherle@uhasselt.be name: Bert Op 't Eijnde, Prof. dr. role: PRINCIPAL_INVESTIGATOR name: Jen Vanherle, Drs. role: SUB_INVESTIGATOR lat: 50.90769 lon: 5.41875 hasResults: False
nctId: NCT06277700 id: CMT001 briefTitle: Effects Of Dynamic Stabilizatıon Exercises And HVLA Manipulatıon in Low Back Paın acronym: DNSHVLA overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-03-01 date: 2024-06-01 date: 2024-02-26 date: 2024-02-26 name: SEFA HAKTAN HATIK class: OTHER briefSummary: Our aim is to contribute to the literature by comparatively examining the effects of DNS exercises and chiropractic HVLA manipulation on pain, pain-related functional impairment (disability), physical competence level, dynamic fitness level of core muscles and postural deviations in patients with chronic nonspecific low back pain. conditions: Low Back Pain conditions: Neuromuscular Subluxation of Joint studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 60 people will participate in the study and the participants will be divided into four groups. The groups will be formed as chiropractic manipulation (CM) group (n=15), dynamic neuromuscular stabilization (DNS) group (n=15), CM + DNS group (n=15) and control group (CG) (n=15). Chiropractic manipulation will be performed once in the side-lying position. An individualized exercise program will be applied to the DNS group under the supervision of a physiotherapist. Kruskal Wallis test for comparisons of quantitative variables between 4 independent groups; Mann Whitney U test with Bonferonni correction will be used in double subgroup comparisons of significant variables. Friedman test was used for comparisons of quantitative variables in 3 dependent groups. Wilcoxon test with Bonferonni correction will be used for two-way subgroup comparisons for significant variables. In all statistical analyzes in the study, results with a p value below 0.05 will be considered statistically significant. primaryPurpose: BASIC_SCIENCE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Chiropractic Manipulation (HVLA - high velocity low amplitude) name: Dynamic Neuromuscular Stabilization measure: Visual Analog Scale measure: Physical Adequacy Level measure: Disability Level measure: Dynamic Stabilization and Adaptibility measure: Posture sex: ALL minimumAge: 20 Years maximumAge: 45 Years stdAges: ADULT facility: Sefa Haktan Haktik city: Sinop country: Turkey lat: 42.02683 lon: 35.16253 hasResults: False
nctId: NCT06277687 id: SYSKY-2024-023-02 briefTitle: Exploratory Study on the Application of Virtual Augmented Reality Combined With Finder in Preoperative Anterolateral Thigh Flap Perforator Positioning overallStatus: RECRUITING date: 2024-02-15 date: 2025-01-01 date: 2026-01-01 date: 2024-02-26 date: 2024-03-19 name: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University class: OTHER briefSummary: Oral and maxillofacial region is an important anatomical part of human body, responsible for chewing, swallowing, language, expression, breathing and other physiological functions. The tissue defects in this area not only seriously affect the physiological function, but also lead to facial deformity and aesthetic damage, affecting the quality of life of patients. The anterolateral thigh flap has become one of the main methods for defect repair due to its large tissue volume and high survival rate, and one of the key steps to ensure a high survival rate is the location of the perforator. How to find the perforator more accurately by improving the detection scheme or locating the perforator according to the anatomical structure, and guide the preparation and cutting of the flap, is the main direction of current research. This study intends to conduct a exploratory study on perforator localization of flap , and explore its effectiveness and accuracy through sensitivity and specificity.
In this study, a total of 24 patients with maxillofacial defects caused by tumors, trauma and other reasons requiring anterolateral femoral flap repair were included, and the perforator branch of femoral anterolateral flap was positioned preoperatively by Virtual augmented reality combined with perforator positioning device and color Doppler ultrasound. After the anterolateral thigh flap was prepared, the incision was closed in the donor area of the leg, and the flap was transplanted free to the maxillofacial defect area for repair. The sensitivity, specificity, positive predictive value, negative predictive value, distance difference and odds ratio of the two methods were calculated respectively, and the differences of each evaluation index between the two groups were compared, mainly to evaluate the sensitivity and specificity between the two groups. conditions: Blood Vessel Perforation studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: After performing CTA examination, input the CTA data into Cinematic Anatomy reconstruction software to analyze blood vessels, muscles and other tissues are reconstructed in three dimensions. Before the operation, the Finder is used to restore the position of the thigh during CTA examination. The Hololens is used to match the reconstructed three-dimensional image with the Finder and the thigh. Before the operation, the pedicles of the descending branches of the lateral arteries and the perforating vessels are marked on the skin of the thigh to achieve the positioning and marking of the perforating branches. primaryPurpose: DIAGNOSTIC masking: NONE count: 24 type: ESTIMATED name: Virtual Augmented Reality Combined With Finder measure: Sensitivity measure: Specificity measure: positive predictive value measure: negative predictive value measure: Youden Index sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University status: RECRUITING city: Guanzhou state: Guangdong zip: 510000 country: China name: Song Fan, Doctor degree role: CONTACT phone: 020-81332477 email: fansong2@mail.sysu.edu.cn name: Song Fan, Doctor degree role: PRINCIPAL_INVESTIGATOR hasResults: False
nctId: NCT06277674 id: ZF2023-252 briefTitle: Efficacy of Cadonilimab in Non-squamous Non-small Cell Lung Cancer Patients Resistant to EGFR-TKI overallStatus: RECRUITING date: 2023-11-02 date: 2024-12 date: 2025-06 date: 2024-02-26 date: 2024-03-08 name: Guangzhou University of Traditional Chinese Medicine class: OTHER name: Akeso Pharmaceuticals, Inc. briefSummary: This study was designed to evaluate the efficacy and safety of cadonilimab (anti PD-1 and CTLA-4 bispecific antibody) in combination with pemetrexed and anlotinib for treatment of elderly patients with T790M-negative advanced non-squamous non-small cell lung cancer following resistance to EGFR-TKI. conditions: Non-small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Cadonilimab plus Pemetrexed and Anlotinib measure: ORR(Objective response rate) measure: Progression-free survival (PFS) measure: (Disease control rate assessed by investigators) DCR (CR+PR+SD) measure: Overall survival (OS) sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Guangdong Provincial Hospital of Traditional Chinese Medicine status: RECRUITING city: Guangzhou state: Guangdong zip: 510120 country: China name: Haibo Zhang, Prof role: CONTACT phone: 86-020-81887233 phoneExt: 34830 email: haibozh@gzucm.edu.cn lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06277661 id: 2023H0305 briefTitle: The Mom and Infant Outcomes (MOMI) Study overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-06-30 date: 2028-05-30 date: 2024-02-26 date: 2024-04-09 name: Ohio State University class: OTHER briefSummary: The investigator's long-term goal is to mitigate pregnancy-related mortality (PRM) risk by systematically delivering integrated clinical and supportive care that is effective, equitable, and scalable. The investigator's central hypothesis is that the Multi-modal Maternal Infant Perinatal Outpatient Delivery System (MOMI PODS) will mitigate postpartum (PP) risk and reduce disparities in PP risk by improving biopsychosocial profiles and facilitating access to evidence-based clinical and supportive care. To test this hypothesis, the investigators will conduct a hybrid type 1 randomized controlled trial (RCT) of MOMI PODS versus enhanced usual care (EUC, which we will term MOMI CARE) among a total sample of 384 mother-infant dyads (192/group) following pregnancy affected by a cardiometabolic and/or mental health condition. The investigators will enroll participants on PP day 1 and collect data at baseline and 6 months and 1 year PP. The investigators will collect implementation and service data across sites. conditions: Postpartum Depression conditions: Postpartum Anxiety conditions: Cardiometabolic Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 384 type: ESTIMATED name: MOMI PODS name: Enhanced Usual Care (EUC) measure: Change in Life's Essential 8 (LE8) Composite Score measure: Change in Life's Essential 8 (LE8) Composite Score measure: Change in Life's Essential 8 (LE8) Composite Score measure: Change in Patient Health Questionnaire-9 (PHQ-9) Score measure: Change in Patient Health Questionnaire-9 (PHQ-9) Score measure: Change in Patient Health Questionnaire-9 (PHQ-9) Score measure: Change in Generalized Anxiety Disorder-7 (GAD-7) Score measure: Change in Generalized Anxiety Disorder-7 (GAD-7) Score measure: Change in Generalized Anxiety Disorder-7 (GAD-7) Score sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: The Ohio State University city: Columbus state: Ohio zip: 43210 country: United States name: Shannon L. Gillespie, PhD, RN role: CONTACT phone: 614-292-4589 email: gillespie.175@osu.edu name: Sandra Solove, MA role: CONTACT phone: 6142478366 email: solove.3@osu.edu lat: 39.96118 lon: -82.99879 hasResults: False
nctId: NCT06277648 id: 18-2021 briefTitle: the Pericapsular Nerve Group (PENG) and Suprainguinal Fascia Iliaca Blocks (SIFIB) in Elderly Patients overallStatus: RECRUITING date: 2022-01-01 date: 2024-04-01 date: 2024-04-15 date: 2024-02-26 date: 2024-02-28 name: Haseki Training and Research Hospital class: OTHER briefSummary: This clinical trial aims to compare the effect of the pericapsular nerve group (PENG) and suprainguinal fascia iliaca blocks (SIFIB) on pain management in elderly patients with subtrochanteric femur fractures.
The participants will be patients determined to have proximal femoral nailing. According to randomisation, each participant will receive either PENG or SIFIB postoperatively after spinal anaesthesia. The investigator will measure postoperative pain scores, total amount of analgesic consumption and motor ability postoperatively. conditions: Collum Femoris Fracture conditions: Pericapsular Nerve Group Block conditions: Suprainguinal Fascia Iliaca Block studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: a double-blind, prospective, randomized, controlled study primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: The orthopaedic surgeon responsible for the study was blinded to the study groups. This surgeon was the sole evaluator of postoperative pain scores and total analgesia consumption. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 75 type: ESTIMATED name: PENG block name: SIFIB measure: pain scores measure: rescue analgesia sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Haseki Training and Research Hospital status: RECRUITING city: Istanbul state: Sultangazi country: Turkey name: Berna Caliskan role: CONTACT email: caliskan.b@gmail.com lat: 41.01384 lon: 28.94966 hasResults: False