hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06378528 id: 2023-1706 id: Protocol Version Jan 2024 type: OTHER domain: UW Madison id: A538900 type: OTHER domain: UW Madison briefTitle: Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP) overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-08 date: 2025-08 date: 2024-04-22 date: 2024-04-22 name: University of Wisconsin, Madison class: OTHER briefSummary: The objectives of this study are to investigate the feasibility, tolerability, and efficacy of repeated ketamine-assisted psychotherapy sessions in adolescents with severe posttraumatic stress disorder. The study will enroll adolescents with a current diagnosis of posttraumatic stress disorder (PTSD) to complete three intravenous ketamine administrations immediately prior to a psychotherapy session over the span of six weeks. All participants will complete an initial set of preparatory sessions, and each dosing session will be followed by three integration sessions. Finally, participants will complete 7 nights of at-home sleep recordings. The investigators hypothesize that this protocol will be well-tolerated by adolescents and that patients will experience decreases in PTSD symptom severity at follow-up. conditions: Posttraumatic Stress Disorder studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: single group, open label, pilot study primaryPurpose: TREATMENT masking: NONE count: 5 type: ESTIMATED name: Ketamine name: SmartSleep EEG recording headband measure: Summary of Adverse Events Attributable to Ketamine Administration measure: Number of Participants Adhering to the Study Protocol measure: Number of Visits Completed Throughout the Study Duration measure: Changes in PTSD symptom severity as measured by the Clinician Administered PTSD Scale Child/Adolescent Version (CAPS-CA) measure: Exploratory Measurements: Change waveform recorded with Philips SmartSleep headband, measured in Hz sex: ALL minimumAge: 15 Years maximumAge: 17 Years stdAges: CHILD facility: University of Wisconsin city: Madison state: Wisconsin zip: 53705 country: United States name: Sara Heyn, JD, PhD role: SUB_INVESTIGATOR name: Stephanie Jones, PhD role: SUB_INVESTIGATOR name: Steven Garlow, MD, PhD role: SUB_INVESTIGATOR name: Paul Hutson, PharmD role: SUB_INVESTIGATOR lat: 43.07305 lon: -89.40123 hasResults: False
nctId: NCT06378515 id: Glymphactive briefTitle: Physical Activity, Sleep and Brain Health Based on the Glymphatic System overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-04 date: 2025-12 date: 2024-04-22 date: 2024-04-22 name: University of Valencia class: OTHER name: University of Oulu briefSummary: This study is aiming to analyze the impact of physical activity on neurohydrodynamics and glymphatic activity on young adults. This study is designed as a multicenter descriptive observational study with information collection at two different times: before performing a short exercise routine and during its performance using a wearable wireless device Glymphometer. conditions: Brain Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 77 type: ESTIMATED name: Physical activity, postural changes and cognitive tasks measure: Brain health measure: Physical activity (habitual) measure: Sleep duration measure: Sleep Quality measure: Chronotype measure: Self-reported health status measure: Other variables sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT hasResults: False
nctId: NCT06378502 id: antibiotic-resistence briefTitle: The Effect of Different Antibiotic Protocols on Peri-implant Tissue Health overallStatus: NOT_YET_RECRUITING date: 2024-05-03 date: 2025-12-30 date: 2026-06-30 date: 2024-04-22 date: 2024-04-22 name: Universita degli Studi di Genova class: OTHER briefSummary: The aim of the present project (non-inferiority trial) is to evaluate the effect of different antibiotic strategies (long-span vs. short-span) for implant surgery on peri-implant tissue health, oral microbiome (included resistome) and salivary MiRNomics in healthy patients. conditions: Antibiotic studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 80 type: ESTIMATED name: Amoxicillin Short name: Amoxicillin Long measure: Mean peri-implant bone loss measure: Incidence of biological and technical complications at the implant site measure: implant survival rate measure: Antibiotic sensitivity measure: Peri-implant myco-, microbiome and resistome measure: Salivary miRNomics measure: Adverse reactions measure: Development of a 3D bone model measure: Plaque index (PI) measure: Bleeding on probing (BOP) measure: Peri-implant pocket probing depth (PPD) sex: ALL minimumAge: 35 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06378489 id: 2022-0346-01 briefTitle: The Use of Etonogestrel Contraceptive Implant as Treatment for Endometrial Hyperplasia Without Atypia: A Cohort Study overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-01-31 date: 2025-05-31 date: 2024-04-22 date: 2024-04-22 name: University of the Philippines class: OTHER name: Organon briefSummary: Endometrial hyperplasia without atypia is a condition in which the endometrium (the lining of the uterus) becomes abnormally thick. Although endometrial hyperplasia without atypia is not cancer, it can lead to endometrial cancer in 1-3% of women. This disease is treated by giving progestins. The optimal route, dosage and duration of progestin treatment for endometrial hyperplasia has not yet been determined until now. However, several publications have suggested the use of levonorgestrel releasing IUD as first-line treatment for endometrial hyperplasia without atypia. The other common medications used are the oral progestins medroxyprogesterone (MPA) and norethisterone acetate (NETA).
The etonogestrel implant (Implant NXT) has been approved for contraceptive use by the US FDA in 2006. The mchanism of action of the implant for contraception suggests a potential application for its use in the treatment on hyperplasia. Off-label use of the implant for adrnomyosis, endometriosis and chronic pelvic pain has already been described in various studies. However, its therapeutic effect on endometrial hyperplasia without atypia has not been studied yet. The researchers propose to use the etonogestrel implant (Implant NXT) as novel treatment for endometrial hyperplasia without atypia. The study aims to determine the rate of regression to normal endometrium among patients with endometrial hyperplasia without atypia at 3 and 6 months after insertion of the implant. conditions: Endometrial Hyperplasia Without Atypia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: Etonogestrel implant measure: Rate of (resolution) regression to normal endometrium measure: Endometrial thickness (by ultrasound) sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06378476 id: 855188 briefTitle: Supportive Understanding and Patient-centered Partnership for Optimizing Renal Treatment acronym: SUPPORT overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-06 date: 2025-09 date: 2024-04-22 date: 2024-04-24 name: University of Pennsylvania class: OTHER briefSummary: Black and Hispanic people face higher risks of chronic kidney disease (CKD) but have unequal access to the highest-quality kidney care. Black adults with CKD face 1.5 times higher hospitalization risks than non-Black adults with CKD. Once reaching end stage kidney disease (ESKD), Black patients are half as likely to receive a transplant and are often excluded from home dialysis. Structural racism creates complex barriers to optimal CKD care, providing an explanation for these findings. The Penn Medicine IMPaCT Community Health Worker (CHW) program is a rigorously tested approach to employ people from local communities to dismantle structural racism within health care systems and improve outcomes for marginalized patients. This trial will innovate by training CHWs to focus specifically on CKD care for minoritized people. The investigators will also train primary care clinicians caring for CKD patients on how to provide trauma-informed care (TIC). The first aim is to determine the feasibility, acceptability, and reach of a clinic-level TIC training to address the needs and concerns of Black and other minoritized patients. The second aim will be to conduct a three arm trial comparing individuals in usual care to individuals randomized to either our tailored CHW intervention in conjunction with clinic-level TIC training or to clinic-level TIC intervention only. The investigators will examine whether patients in the intervention arms have greater improvements in quality of life (primary). The investigators will also explore the impact of the interventions on patient activation, hospitalizations, and ESKD treatment preferences. conditions: Chronic Kidney Diseases conditions: Racism, Systemic conditions: Trauma, Psychological studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE maskingDescription: Research coordinators collecting baseline and outcomes data from participants will be blinded to arm. whoMasked: OUTCOMES_ASSESSOR count: 150 type: ESTIMATED name: IMPaCT Community Health Worker Program name: Trauma-Informed Care Training measure: Kidney Disease Quality of Life Instrument (KDQOL) measure: Patient Activation Measure measure: All-Cause Hospitalizations measure: Patient preferences for end-stage renal disease treatment sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06378450 id: 2022-23892-31512-2 briefTitle: Dose-Response Effects of Mindfulness Meditation overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2024-11-30 date: 2024-11-30 date: 2024-04-22 date: 2024-04-24 name: University of Melbourne class: OTHER briefSummary: The goal of this randomized controlled trial is to test for evidence of dose-response effects in a sample of healthy adults with little to no prior experience with meditation.
Participants will take a 28-day mindfulness meditation course, with guided audio instructions provided daily throughout the intervention period (excluding one rest day per week). They will also be asked to respond to surveys before, during, and after the intervention. conditions: Well-Being, Psychological conditions: Depression studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 860 type: ESTIMATED name: Mindfulness meditation guided practice measure: Psychological wellbeing measure: Psychological Distress measure: Anxiety measure: Depression measure: Nonattachment measure: Trait Mindfulness measure: Decentering measure: Equanimity measure: Repetitive Negative Thoughts measure: Emotional Regulation measure: Attentional Control measure: Emotional Reactivity measure: Social Anxiety measure: Sleep Quality measure: Momentary Mood measure: State Mindfulness measure: Attention measure: Decentering measure: Mindful Attitudes sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06378424 id: 2023-6/6 briefTitle: The Effectiveness of Local Dry Cold, Hot and Vibration Applications in Peripheral Intravenous Catheterization overallStatus: COMPLETED date: 2023-03-22 date: 2023-03-22 date: 2023-08-23 date: 2024-04-22 date: 2024-04-22 name: Uludag University class: OTHER briefSummary: Aim: The aim of the present study was to examine the effect on venous dilation, procedure duration and pain severity of local hot, cold and vibration applications performed on the intervention area before peripheral intravenous catheterization in adults.
Methods: The study included 120 adults who were randomly selected between March and August 2023. One application group (n=30) received local hot application, one group (n=30) received local cold application, and one (n=30) received local vibration using the Buzzy® device. The applications, to the site of the peripheral intravenous catheterization, lasted one minute. The control group (n=30) the received standard peripheral intravenous catheterization application. The groups' venous dilation was assessed on the vein assessment scale and the level of pain felt during catheterization was assessed using a visual analog scale. conditions: Pain Management conditions: Emergency Unit conditions: Diarrhea conditions: Nausea conditions: Vomiting studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 120 type: ACTUAL name: Cold Application name: Heat Application name: Vibration Application measure: pain intensity in mm measure: venous dilation in score measure: procedure duration in sec measure: weight measure: height sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bursa Uludag University Hospital city: Bursa state: Nilüfer country: Turkey lat: 40.19559 lon: 29.06013 hasResults: False
nctId: NCT06378411 id: P109 briefTitle: Development and Application of a Musical Game for Motor Rehabilitation overallStatus: RECRUITING date: 2024-04-04 date: 2024-07 date: 2024-10 date: 2024-04-22 date: 2024-04-22 name: Universidade da Madeira class: OTHER briefSummary: The aim of this study is to develop, adapt a musical game for residents of RAM, and evaluated the usability and correlation between this game with the improvement of motor coordination in short time. conditions: Health People conditions: Survivors of Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 45 type: ESTIMATED name: Music Game Intervention measure: Motor Coordination measure: Usability sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Universidade da Madeira status: RECRUITING city: Funchal country: Portugal name: Yasmim Moniz, Master role: CONTACT phone: +351 968412551 email: yasmimfernandes08@hotmail.com role: CONTACT email: yasmimfernandes08@hotmail.com lat: 32.66568 lon: -16.92547 hasResults: False
nctId: NCT06378398 id: UMCC 2023.037 id: HUM00247729 type: OTHER domain: University of Michigan id: UMI23-13-01 type: OTHER domain: DCP Protocol Number id: 1UG1CA242632-01A1 type: NIH link: https://reporter.nih.gov/quickSearch/1UG1CA242632-01A1 briefTitle: A Trial of Omeprazole and Low Dose Aspirin to Identify Colorectal Biomarkers of Preventive Efficacy overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-08 date: 2024-08 date: 2024-04-22 date: 2024-04-22 name: University of Michigan Rogel Cancer Center class: OTHER name: National Cancer Institute (NCI) briefSummary: This trial will obtain biomarker data on the possible preventive effects of omeprazole and low-dose aspirin in colorectal tissue. Persons who have had 5 or more adenomas, 5 or more serrated polyps, or an incompletely removed adenoma or serrated polyp in the colon or rectum are potentially eligible. Before participating in the study, study staff will explain the study and review the consent form. If you are interested and provide consent, study staff will then confirm your eligibility. Once enrolled, participants will take two 20 mg omeprazole tablets and two 81 mg aspirin tablets each day before the first meal each day for 25-45 days.
The study does involve biopsies of the colorectal tissue before and after taking the study medications. The biopsies are samples of tissue, about the size of a grain of rice, that will be taken from the colon or rectum before and after taking the study medications. This is done during a usual, clinical colonoscopy exam and during one more limited exam, called flexible sigmoidoscopy, that is done for the research study. The flexible sigmoidoscopy requires less preparation. Which procedure comes first depends on what fits best with each participant's clinical scenario. Biopsies of both normal mucosa and polyps (if possible) are collected. conditions: Colorectal Neoplasia studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 24 type: ESTIMATED name: Omeprazole name: Aspirin measure: Identification of biomarkers for omeprazole/aspirin combination treatment in the human colorectum measure: Evaluation of gene expression changes sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The University of Michigan Rogel Cancer Center city: Ann Arbor state: Michigan zip: 48109 country: United States name: Kirsten Tuck role: CONTACT phone: 734-763-1141 email: KLtuck@med.umich.edu name: Elena Stoffel, MD role: PRINCIPAL_INVESTIGATOR lat: 42.27756 lon: -83.74088 facility: Ohio State University Comprehensive Cancer Center city: Columbus state: Ohio zip: 43210 country: United States name: Kebire Gofar role: CONTACT email: Kebire.Gofar@osumc.edu name: Peter Stanich, MD role: PRINCIPAL_INVESTIGATOR lat: 39.96118 lon: -82.99879 hasResults: False
nctId: NCT06378385 id: DevelopmentCEOAS briefTitle: Development and Content Validation of the Childhood Early Oral Aging Syndrome (CEOAS) Index for the Deciduous Dentition overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-10-31 date: 2024-12-20 date: 2024-04-22 date: 2024-04-25 name: University of Nove de Julho class: OTHER briefSummary: Premature, non-physiological tooth wear in childhood has numerous repercussions for oral health. This is a growing problem with multifactorial causes and associated with the current lifestyle. The aim of the present study was the development and determination of content validity of the Childhood Early Oral Aging Syndrome (CEOAS) index for the primary dentition as a diagnostic and epidemiological survey tool considering the current changes found in this population. conditions: Aging studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 6 type: ESTIMATED name: Childhood Early Oral Aging Syndrome index measure: Development of CEOAS index measure: Validation of CEOAS index sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Universidade Metropolitana de Santos - UNIMES city: Santos state: São Paulo zip: 11045-002 country: Brazil lat: -23.96083 lon: -46.33361 hasResults: False
nctId: NCT06378372 id: ETICA-ULE-064-2023 briefTitle: How Does Pianistic Musical Training Influence the Development of Alzheimer's Disease? overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-08-01 date: 2025-06-01 date: 2024-04-22 date: 2024-04-22 name: David Franco Castellanos class: OTHER name: Jesús Ángel Seco Calvo name: Javier Tejada Garcia briefSummary: The goal of this clinical trial is to learn about and describe how pianistic training influences the development of Alzheimer's disease.
Participants will receive piano lessons for 4 weeks (20 sessions) and we will evaluate the evolution of the different parameters described by the tests carried out. conditions: Dementia of Alzheimer Type conditions: Dementia conditions: Dementia, Vascular conditions: Dementia, Mixed conditions: Dementia Frontal conditions: Dementia With Lewy Bodies conditions: Cognitive Decline conditions: Neurologic Disorder conditions: Neurologic Dysfunction conditions: Neurologic Deficits studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: An intervention based on teaching the piano in an individualized way primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 20 type: ESTIMATED name: Music therapy based on piano learning measure: State of global deterioration measure: Minimental Test measure: RDRS-2 Rapid Disability Assessment Scale measure: MONTREAL COGNITIVE ASSESSMENT (MOCA) measure: WAIS-IV measure: Behavioral disorders: BEHAVE-AD measure: NPI - CUMMINGS measure: Evaluation of the caregiver's burden (Zarit test) sex: ALL minimumAge: 50 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Universidad de León city: León state: Castilla Y León zip: 24004 country: Spain lat: 42.60003 lon: -5.57032 hasResults: False
nctId: NCT06378359 id: IDIM-2023-32364 briefTitle: Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients overallStatus: RECRUITING date: 2024-01-29 date: 2025-12-31 date: 2026-12-31 date: 2024-04-22 date: 2024-04-22 name: University of Minnesota class: OTHER briefSummary: The purpose of the study is to determine the effectiveness, safety, and health-care utilization and costs of a preoperative Staphylococcus aureus (SA) screening and decolonization bundle, (5 days of nasal mupirocin ointment, chlorhexidine gluconate (CHG) body wash, and CHG mouth rinse), in eradicating SA carriage compared to other SA decolonization approaches. The study will conduct a single center pilot trial to compare efficacy of different SA decolonization approaches in pre-surgical patients, in eradicating SA carriage, after obtaining informed consent.
The study will compare four different approaches, Arm 1) screen for SA carriage and using the three-drug decolonization bundle for 5 days among patients with SA colonization, non SA carriers in this arm will get two pre-op showers with CHG soap, Arm 2) all participants receive the three drug decolonization bundle, Arm 3) all receive pre-op nasal povidone iodine the day of surgery plus two pre-op showers with CHG soap, and Arm 4) all receive nasal alcohol gel the day of surgery plus two pre op showers with CHG soap.
The primary efficacy outcome will be eradication of SA colonization at all 5 body sites. Secondary outcomes will be SA surgical site infections (SSIs), all SSIs, and SA healthcare associated infections (HAIs). The study will also compare eradication of SA from each of the 5 body sites as a secondary outcome. conditions: Staphylococcus Aureus Colonization conditions: Surgical Site Infections conditions: Healthcare Associated Infections studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 250 type: ESTIMATED name: Screening and decolonization for SA carriers with the 3 drug bundle name: No screening for SA name: no screening name: Nasal povidone-iodine on surgery day plus 2 CHG pre-op showers without screening. name: Nasal alcohol gel on surgery day plus 2 CHG pre-op showers without screening measure: Efficacy in eradicating Staphylococcus aureus (SA) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Minnesota Medical Center and Clinics status: RECRUITING city: Minneapolis state: Minnesota zip: 55414 country: United States name: Pragya Karki, MD role: CONTACT phone: 612-301-6316 email: pkarki@umn.edu lat: 44.97997 lon: -93.26384 hasResults: False