hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06380140 id: cami3zgmxf3vqyc30ndmdqh6gfjid1 briefTitle: Relationship Between Acute Phase Markers and Post-operative Pain in Open Tension-free Inguinal Hernia Repair: An Observational Study overallStatus: RECRUITING date: 2023-05-03 date: 2024-03-03 date: 2025-12-31 date: 2024-04-23 date: 2024-04-23 name: University of Roma La Sapienza class: OTHER briefSummary: Many patients undergoing inguinal hernia repair are prone to developing acute and chronic post-operative pain.
* select most suitable pain relief therapy for the patient. conditions: Post Operative Pain conditions: Inguinal Hernia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 71 type: ESTIMATED name: Open Tension-free Inguinal Hernia Repair measure: Relationship Between Post-operative Pain and C Reactive Protein (CRP) in Open Tension-free Inguinal Hernia Repair measure: Relationship Between Post-operative Pain and D-dimer in Open Tension-free Inguinal Hernia Repair measure: Relationship Between Post-operative Pain and Fibrinogen in Open Tension-free Inguinal Hernia Repair measure: Relationship Between Post-operative Pain and white blood cell count in Open Tension-free Inguinal Hernia Repair measure: Relationship Between Post-operative Pain and Neutrophil to Lymphocyte Ratio (NLR) in Open Tension-free Inguinal Hernia Repair sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Augusto Lauro status: RECRUITING city: Roma zip: 000186 country: Italy name: Augusto Lauro role: CONTACT phone: +39 388 8663 879 email: augusto.lauro@uniroma1.it lat: 41.89193 lon: 12.51133 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-05-03 uploadDate: 2024-04-18T14:17 filename: Prot_SAP_000.pdf size: 274127 hasResults: False
nctId: NCT06380127 id: CEFADE012021 briefTitle: Feasibility and Effectiveness of Concurrent Exercise Training on Frail Older Adults Living in Nursing Homes overallStatus: COMPLETED date: 2021-10-01 date: 2023-09-30 date: 2023-12-15 date: 2024-04-23 date: 2024-04-24 name: Universidade do Porto class: OTHER briefSummary: The present study is a crossover randomized controlled trial that aims to investigate the effects of concurrent exercise training over usual care on physical performance, muscle strength, and myokines concentrations in frail older adults living in nursing homes.The main questions it aims to answer is: Can a 12-week exercise intervention provide beneficial effects on physical performance, muscle strength and myokines among the most frail participants? Researchers will compare this intervention to usual care. Nursing homes (comprising participants) will be randomly assigned to a sequence of interventions (AB or BA), being A -exercise and B usual care. Participants will be assessed before and after each intervention. conditions: Frailty studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: The trial will follow a 28-week crossover design: 12 weeks for the first intervention period, a 4-week washout, and another 12 weeks for the second intervention period. Nursing homes (clusters) were randomized into sequences (AB or BA), where intervention A involve concurrent exercise training, and B is usual care.
Data collection will occurre at four points: baseline, post-first intervention period, post-washout/pre-second intervention period and post-crossover. primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 46 type: ACTUAL name: Exercise training measure: Change from Baseline on Short Physical Performance Battery (SPBB) measure: Change from Baseline on Handgrip test measure: Change from baseline on isokinetic knee strength measure: Change from Baseline on circulating levels of myostatin measure: Change from Baseline on circulating levels of Decorin sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Faculty of Sports, University of Porto city: Porto zip: 4000 country: Portugal lat: 41.14961 lon: -8.61099 hasResults: False
nctId: NCT06380114 id: STUDY00009296 briefTitle: Stand Up 2 HPV: Standing Orders to Improve HPV Vaccination overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2026-04 date: 2027-11 date: 2024-04-23 date: 2024-04-25 name: University of Rochester class: OTHER name: National Institutes of Health (NIH) briefSummary: Each year in the U.S., ≥20,000 women and 14,000 men are affected by HPV-related cancers, including cervical and oropharyngeal cancer. However, in 2020, only 59% of U.S. adolescents aged 13-17 were up-to-date for HPV vaccination, and rates for 11-12 year olds, the primary target age group for HPV vaccination (when the immune reaction is better and before exposure to HPV infection), are even lower. Standing orders (written protocols that authorize designated members of the healthcare team to vaccinate without first obtaining a patient-specific physician order) have been shown to work in inpatient settings and for adults, but have not been evaluated for HPV vaccine, which some parents consider controversial. Also, the ways in which organizational readiness for change (resources, motivation, staff attributes, leadership support and culture) moderate the effect of standing orders has not been studied. A physician's recommendation is correlated with HPV vaccine acceptance, and the investigators have developed a successful online, interactive, communication education program that will be adapted to train nurses and staff in addition to physicians. The investigators propose testing standing orders for HPV vaccine in an Accountable Care Organization (ACO) in Western New York, and assessing which provider and practice factors moderate the effect of standing orders. Advantages of this setting include a diverse group of rural, urban and suburban practices, and the ACO provides data infrastructure and analytics that allow practices to evaluate vaccination rates in real time.
Using a 2-arm cluster randomized trial (n=40 practices), the investigators will assess the effectiveness of standing orders (SO) + HPV communication education (intervention arm) relative to HPV communication education alone (control arm) on HPV vaccination for 11-17 year-olds. conditions: Hpv studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 16000 type: ESTIMATED name: Communication name: Standing Orders measure: HPV vaccination sex: ALL minimumAge: 11 Years maximumAge: 17 Years stdAges: CHILD hasResults: False
nctId: NCT06380101 id: NEAAR-LARC briefTitle: Evaluating a Nonessential Amino Acid Restriction (NEAAR) Medical Food With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer (LARC) acronym: NEAAR-LARC overallStatus: RECRUITING date: 2023-09-08 date: 2024-12 date: 2025-06 date: 2024-04-23 date: 2024-04-23 name: University of South Florida class: OTHER briefSummary: This clinical study aims to assess feasibility, safety, tolerability, and compliance of a Nonessential Amino Acid Restriction (NEAAR) medical food in adult patients with locally advanced rectal cancer during standard of care short course radiotherapy followed by standard of care chemotherapy. conditions: Rectal Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 30 type: ESTIMATED name: NEAAR Medical Food measure: Rate of CTCAE v5.0 non-hematological Grade 3 and higher diarrhea measure: Proportion of clinical complete response 8 weeks post SCRT-TNT with NEAAR medical food defined by the MSK Regression Schema measure: Absolute and relative change from baseline of circulating non-essential amino acids measure: Proportion of clinical complete response at Week 4 post SCRT with NEAAR medical food measure: molecular ctDNA response. sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of South Florida status: RECRUITING city: Tampa state: Florida zip: 33606 country: United States name: Jennifer Burgess, MS role: CONTACT phone: 434-806-6445 email: jburgess@tgh.org name: Veronique Perry, MSHA role: CONTACT phone: 2549873658 email: vperry@tgh.org name: Richard Tuli, MD role: PRINCIPAL_INVESTIGATOR lat: 27.94752 lon: -82.45843 hasResults: False
nctId: NCT06380088 id: VEM-DINOGMI-24 briefTitle: Improving Motor Skills: The Role of Music and Encouragement overallStatus: COMPLETED date: 2022-07-01 date: 2023-08-05 date: 2024-03-15 date: 2024-04-23 date: 2024-04-23 name: Universita degli Studi di Genova class: OTHER briefSummary: This study used a randomised crossover design to analyse the effect of three different experimental interventions - i.e. standard conditions, music and verbal encouragement - on performance in an isometric endurance task, comparing results between untrained and trained individuals. The interval between each intervention was set at seven days. The outcome measures are muscle activity and fatigue, assessed by surface electromyography, and task duration.
Isometric endurance task requires participants to keep their arm flexed at a 90° angle while holding a dumbbell with a supine grip loaded to 80% of 1RM on the dominant side of the body. During execution, the back and head should remain in contact with a vertical wall, with the feet shoulder width apart and firmly planted on the floor. The bar is held with the dominant arm while the other arm remains in a neutral position close to the body. It is imperative to avoid any form of rocking or movement that would make it easier to maintain the position. The test officially begins when the bar is handed to the subject, who is already in the correct position, and ends as soon as the angle of the arm varies by more than five degrees from the starting position. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: NONE count: 25 type: ACTUAL name: Isometric Task measure: Duration of the task measure: Biceps Brachii muscle fatigue measure: Triceps Brachii muscle fatigue measure: Biceps Brachii activity measure: Triceps Brachii activity sex: ALL minimumAge: 27 Years maximumAge: 40 Years stdAges: ADULT facility: Università degli Studi di Genova city: Genova zip: 16122 country: Italy lat: 44.40478 lon: 8.94438 hasResults: False
nctId: NCT06380075 id: 2024-0480 id: A536000 type: OTHER domain: UW Madison id: SMPH/OPHTHAL&VIS SCI/GEN type: OTHER domain: UW Madison id: Protocol Version 3/22/24 type: OTHER domain: UW Madison briefTitle: COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Inherited Retinal Disease acronym: COCO-IRD overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-05 date: 2024-04-23 date: 2024-04-23 name: University of Wisconsin, Madison class: OTHER briefSummary: The goal of this research study is to compare two ultrawide field cameras to the gold standard imaging system to evaluate the back of the eye. The main question it aims to answer is the same results and information can be acquired from all of the cameras for evaluating and monitoring inherited retinal diseases (IRDs).
* have photographs taken of the inside of the eyes using three different cameras conditions: Retinal Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 50 type: ESTIMATED name: Spectralis FAF imaging name: Optos imaging name: Clarus imaging measure: Compare FAF retinal patterns by Clarus and standard Spectralis FAF imaging measure: Compare FAF retinal patterns by Optos and standard Spectralis FAF imaging measure: Compare FAF retinal patterns by Clarus and Optos FAF imaging measure: Compare Spectralis FAF imaging to Spectralis OCT imaging measure: Prevalence of FAF retinal pattern changes beyond the standard 30 degress in Clarus and Optos ultrawide field images measure: Prevalence of other autofluorescence abnormalities unique to the IRD across all imaging sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Ophthalmology and Visual Sciences city: Madison state: Wisconsin zip: 53705 country: United States name: Amy Remm role: CONTACT phone: 608-262-3377 email: amy.remm@wisc.edu name: Kimberly Stepien, MD role: PRINCIPAL_INVESTIGATOR lat: 43.07305 lon: -89.40123 hasResults: False
nctId: NCT06380062 id: Choline Prostate Cancer briefTitle: Choline Metabolites in People With Prostate Cancer and Those With Benign Hyperplasia overallStatus: COMPLETED date: 2012-01-12 date: 2015-11-30 date: 2015-11-30 date: 2024-04-23 date: 2024-04-25 name: Universität des Saarlandes class: OTHER briefSummary: The aim of this study was to investigate plasma concentrations of one-carbon metabolites and phospholipid classes in participants with primary prostate cancer and those with benign hyperplasia. Moreover, the metabolites were studied in relation to tumor grade and age. conditions: Primary Prostate Urothelial Cancer conditions: Benign Prostatic Hyperplasia studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 350 type: ACTUAL name: Plasma concentration of choline measure: Plasma choline concentrations measure: Whole blood choline concentrations measure: Plasma and whole blood folate forms measure: Plasma phospholipids measure: Plasma S-adenosylmethionine concentrations measure: Plasma betaine concentrations measure: Plasma methylmalonic acid concentrations measure: Plasma homocysteine concentrations sex: MALE minimumAge: 50 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Saarland city: Homburg state: Saarland zip: 66424 country: Germany lat: 49.32637 lon: 7.33867 hasResults: False
nctId: NCT06380049 id: 0720242110 id: 20240012366 type: OTHER domain: Ministry of Food and Drug Safety briefTitle: Predicting Fall Risk in Stroke Patients Using a Machine Learning Model and Multi-Sensor Data overallStatus: NOT_YET_RECRUITING date: 2024-04-29 date: 2025-04-28 date: 2026-04-28 date: 2024-04-23 date: 2024-04-23 name: Seoul National University Hospital class: OTHER name: Ministry of Trade, Industry & Energy, Republic of Korea briefSummary: The study assesses a machine learning model developed to predict fall risk among stroke patients using multi-sensor signals. This prospective, multicenter, open-label, sponsor-initiated confirmatory trial aims to validate the safety and efficacy of the model which utilizes electromyography (EMG) signals to categorize patients into high-risk or low-risk fall categories. The innovative approach hopes to offer a predictive tool that enhances preventative strategies in clinical settings, potentially reducing fall-related injuries in stroke survivors. conditions: Stroke conditions: Fall studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 90 type: ESTIMATED name: EMG Analysis Software measure: Sensitivity of the Machine Learning Model measure: Specificity of the Machine Learning Model measure: Area Under the Receiver Operating Characteristic Curve measure: Matthews Correlation Coefficient sex: ALL minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06380036 id: 003AEstb/EC/01/2022 briefTitle: Two Approaches to Lower the Chances of Recurrence of Anal Fistula After Surgery overallStatus: COMPLETED date: 2022-11-01 date: 2023-10-31 date: 2023-10-31 date: 2024-04-23 date: 2024-04-23 name: Sairah Sadaf class: OTHER_GOV briefSummary: A total of 80 patients with complex fistula in ano of both genders were included. All patients in Group A underwent a loose seton technique. In group B, video-assisted fistula tract surgery (VAAFTS) was performed.Twice daily Sitz baths, analgesics, and stool bulking agents (bran) were used in follow-up care. Repeated examinations were carried out every four weeks and recurrence was noted at the end of three months conditions: Fistula in Ano studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 80 type: ACTUAL name: video assisted fistula tract surgery measure: recurrence sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sheikh Zayed Medical College city: Rahim yar khan state: Punjab zip: 64200 country: Pakistan lat: 28.41987 lon: 70.30345 hasResults: False
nctId: NCT06380023 id: 2022.354 briefTitle: An Investigation Into the Dispersion Pattern During Coughing and Open Nasopharyngeal Suction Using Various Barrier Devices overallStatus: COMPLETED date: 2022-09-01 date: 2024-03-03 date: 2024-03-03 date: 2024-04-23 date: 2024-04-23 name: North District Hospital class: OTHER name: The Hong Kong Polytechnic University briefSummary: The aim of the study is to examine the air dispersion pattern and the environmental influence of open airway suction in general ward setting. Secondly, the study is aimed at identifying a simple \& practical enclosure device in general ward. Suction will be performed in manikin in supine lying.
3. To evaluate how effective the enclosure barrier in reducing the air particle dispersion during open airway suction. conditions: Airway Aspiration studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 13 type: ACTUAL name: Enclosure barrier measure: Air particle count measure: A fluorescent Dye sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: North District Hospital city: Hong Kong zip: 000000 country: Hong Kong lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06380010 id: IASO HOSPITAL (ATHENS-GREECE) briefTitle: Mediterranean Diet Intervention in Adolescents With Polycystic Ovary Syndrome overallStatus: COMPLETED date: 2019-12-01 date: 2020-03-31 date: 2020-06-30 date: 2024-04-23 date: 2024-04-23 name: Iaso Maternity Hospital, Athens, Greece class: OTHER name: Harokopio University name: University of Peloponnese briefSummary: The aim of the present randomized controlled study was to examine wether a clinical decision support stystem would increase the adherence to the Mediterranean diet (MD) of adolescent girls, aged 15-17 years, diagnosed with polycystic ovary syndrome. The intervention lasted for 3 months and in total, 40 girls were randomly assigned to either the MD group (n=20) or a Control group receiving general nutritional advice (n=20). Anthropometry, nutritional intake, psychological well-being, and blood markers were analyzed at the begninning and the end of the trial. conditions: Polycystic Ovary Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Recruitment involved adolescents with polycystic ovary syndrome. Participants, who expressed their willingness to take part, attended personal meetings with the appointed dieticians who provided comprehensive explanations on the objectives, methods, and the potential benefits/risks of the study. A leaflet with related information was provided to all patients. Every eligible volunteer, and their guardian, signed a written informed consent and then kept a hard copy of the signed document. All eligible females were recruited in 12/2019 and were randomly allocated in groups of one to either the Control group (CG) or the Intervention group (IG). The IG received a personalized Mediterranean dietary plan, delivered through a clinical decision support system, while the CG received general dietary advice. Every participant had two individual sessions with the assigned dietician, at the beginning and at the trial endpoint, which involved anthropometry, dietary assessment, and blood withdrawal. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Treatment allocation was not revealed to the appointed statistician until the end of the study and release of the final outcomes. whoMasked: OUTCOMES_ASSESSOR count: 40 type: ACTUAL name: Mediterranean diet group measure: Adherance to the Mediterranean diet measure: Improvement of psychological well-being sex: FEMALE minimumAge: 15 Years maximumAge: 17 Years stdAges: CHILD facility: IASO Hospital city: Athens zip: 15123 country: Greece lat: 37.97945 lon: 23.71622 hasResults: False
nctId: NCT06379997 id: SANTA LUCIA IRCCS briefTitle: Oral Supplementation Compared With Hyaluronic Acid Infiltration in Rotator Cuff Tendinopathies overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2025-11-01 date: 2025-12-31 date: 2024-04-23 date: 2024-04-25 name: I.R.C.C.S. Fondazione Santa Lucia class: OTHER briefSummary: The present study aims to investigate the effectiveness of oral supplementation with a nutraceutical containing Collagen, Hyaluronic Acid, Vitamin C, and Manganese in functional outcome and pain reduction in cases of shoulder rotator cuff tendinopathy compared to a cycle of intra-articular hyaluronic acid injections.
The project involves the recruitment of 50 adult individuals presenting with shoulder pain and instrumental evidence of rotator cuff tendinopathy. All participants will receive one intra-articular injection of 1 ml of triamcinolone acetonide 40 mg. After the injection, participants will be divided into two groups according to Good Clinical Practice guidelines. One group will begin taking one vial per day for 56 days of an oral supplement containing Hyaluronic Acid, Collagen, Vitamin C, and Manganese (HA-COL) (Tendogenial®, B2Pharma) starting from the day following enrollment (Group 1). The other group will undergo a cycle of 3 intra-articular injections with hyaluronic acid (HA) (Hyalotend®, Fidia) (Group 2).
T3) Follow-up at 28 days from T2, at the end of the 56-day oral treatment cycle for Group 1, and 28 days after the last injection for Group 2 (T3, 56 days from T0). conditions: Tendinitis of Shoulder conditions: Hyaluronic Acid conditions: Dietary Supplements conditions: Shoulder Pain studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: The enrolling physiatrist, in agreement with the patient and adhering to Good Clinical Practice standards related to safety and clinical-anthropomorphic characteristics, will decide whether to continue the treatment with oral supplements (Group 1 - G1) or with intra-articular hyaluronic acid (Group 2 - G2) primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Both study groups will undergo assessment using pain and functional scales by a clinician who is blinded to the treatment group whoMasked: INVESTIGATOR count: 50 type: ESTIMATED name: Collagen, Hyaluronic Acid, Vitamin C, and Manganese name: Intra-articular infiltration measure: Numeric rating scale (NRS) measure: Shoulder Disability Questionnaire (SDQ) for shoulder functionality sex: ALL minimumAge: 30 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06379984 id: 855013 briefTitle: Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use acronym: ROLDI overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-31 date: 2025-12-31 date: 2024-04-23 date: 2024-04-24 name: University of Pennsylvania class: OTHER name: National Institute on Drug Abuse (NIDA) briefSummary: The goal of this clinical trial is to learn if buprenorphine can be started for opioid use disorder with fentanyl use without requiring or precipitating opioid withdrawal. To be eligible, participants must have moderate or severe opioid use disorder and must have fentanyl detected on a urine drug test.
For standard initiation, participants will be instructed to arrive to the unit with at least 8 hours since last fentanyl use. Once they have at least moderately severe opioid withdrawal (Clinical Opiate Withdrawal Scale \[COWS\] 11 or higher), participants will receive 2 mg, 2 mg, 4 mg, and then 8 mg sublingual buprenorphine, with doses every 2 hours. They will then continue 8-12 mg twice daily. This is the current standard of care.
For ROLDI, participants will not be required to have a period abstinence, they will have no or minimal withdrawal (COWS 4 or less) when starting buprenorphine, and participants will take 0.5 mg, 0.5 mg, 1 mg, 1 mg, 1 mg, and then 4 mg sublingual buprenorphine with dosing every two hours. They will then continue 8-12 mg twice daily.