hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06298344 id: 002 briefTitle: The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-12-31 date: 2025-01-01 date: 2024-03-07 date: 2024-03-07 name: Universitas Sumatera Utara class: OTHER briefSummary: Currently, research on the effect of thiamine administration during transcatheter closure on the structure and function of the left ventricle by examining levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in children with left to right shunt congenital heart disease has never been carried out in Indonesia, so it is necessary carried out this research. This research was carried out by administering 100 mg of thiamine once per day to patients post transcatheter closure for 28 days. The parameters assessed were MMP-9, TIMP-1, and echocardiography to assess the structure and function of the left ventricle in CHD patients with left to right shunt lesions. conditions: Congenital Heart Disease conditions: Thiamine Deficiency conditions: Patent Ductus Arteriosus conditions: Ventricular Septal Defect conditions: Atrial Septal Defect studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Double blind primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 88 type: ESTIMATED name: Thiamine measure: Correlation between transcatheter closure and left ventricular structure change after thiamine treatment measure: Correlation between transcatheter closure and left ventricular function change after thiamine treatment measure: Correlation between transcatheter closure and serum matrix metalloproteinase-9 level change after thiamine treatment measure: Correlation between transcatheter closure and serum tissue inhibitor of metalloproteinase-1 level change after thiamine treatment sex: ALL minimumAge: 6 Months maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Universitas Sumatera Utara city: Medan state: North Sumatera zip: 20155 country: Indonesia name: Putri Amelia role: CONTACT phone: +6285261000273 email: putri.amelia@usu.ac.id lat: 3.58333 lon: 98.66667 hasResults: False
nctId: NCT06298331 id: KA-23073 briefTitle: Investigation of the Additional Effects of Aerobic Exercise Training to Abdominal Massage in Functional Constipation overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2026-03-15 date: 2026-03-15 date: 2024-03-07 date: 2024-03-07 name: Hacettepe University class: OTHER briefSummary: The aim of this study was to investigate the additional effects of aerobic exercise to abdominal massage in patients with functional constipation. There are several studies investigating the effects of massage and aerobic exercise separately in functional constipation. However, to the best of our knowledge, there are no studies combining abdominal massage and aerobic exercise to demonstrate additional effects. By combining these two approaches, we believe that a higher and broader effect (local and systemic) and perhaps a cure for constipation (reaching the ideal defecation frequency or asymptomatic status) can be achieved. Therefore, this study will include individuals between the ages of 18-65 who have a diagnosis of functional constipation and who agree to participate in the study. This study is designed as a randomized controlled trial. conditions: Constipation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 44 type: ESTIMATED name: Aerobic Exercise name: Abdominal Massage name: Patient Education measure: Weekly defecation frequency measure: Average weekly defecation time measure: Average weekly frequency of laxative use measure: Average weekly stool consistency score measure: The severity of constipation and associated discomfort measure: The severity of constipation measure: Gastrointestinal symptom level measure: Constipation-related quality of life measure: Patient perception of global change measure: Abdominal muscle strength measure: Functional exercise capacity sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ceren Gursen city: Ankara zip: 06100 country: Turkey name: Serap ÖZGÜL role: CONTACT phone: +905339390803 email: serapky@yahoo.com name: Hatice Yasemin Balaban role: SUB_INVESTIGATOR name: Türkan Akbayrak role: SUB_INVESTIGATOR name: Halis Şimşek role: SUB_INVESTIGATOR name: Beyza Atay role: SUB_INVESTIGATOR name: Ege Nur Atabey Gerlegiz role: SUB_INVESTIGATOR name: İrem Gül Doğan role: SUB_INVESTIGATOR lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06298318 id: Acute Binge Drink briefTitle: Metabolic Changes in Healthy Subjects With Acute Binge Drink acronym: MeABD overallStatus: ENROLLING_BY_INVITATION date: 2024-04-18 date: 2024-07-19 date: 2026-07-18 date: 2024-03-07 date: 2024-04-17 name: Zhejiang Chinese Medical University class: OTHER_GOV briefSummary: The goal of this double-blinded, randomized trial is to investigate the effects of acute binge drink on liver function, liver fat content and lipid metabolism in healthy young subjects. The main questions it aims to answer are:
1. if acute binge drink could alleviate liver injury and hepatic steatosis. conditions: Binge Drinking conditions: Liver Injury conditions: Hepatic Steatosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: vodka name: water measure: Hepatic fibrosis change measure: hepatic function change measure: hepatic injury change measure: Lipid metabolism change measure: Laboratory markers of inflammation measure: Fecal metabolites measure: Ethanol concentration measure: Acetaldehyde concentration measure: hangover cognition assessment tools after drinking sex: MALE minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Zhejiang Chinese Medical University city: Hangzhou state: Zhejiang zip: 310053 country: China lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06298305 id: QUANTIB briefTitle: Artificial Intelligence & Prostate Cancer acronym: QUANTIB overallStatus: ACTIVE_NOT_RECRUITING date: 2022-09-01 date: 2023-10-10 date: 2024-12 date: 2024-03-07 date: 2024-03-07 name: IRCCS San Raffaele class: OTHER briefSummary: This is a single center, blinded (the mpMRI will be read by expert personnel not aware of the patient's diagnosis ), retrospective study. A total of 200 patients with suspicious prostate cancer (PCa) who underwent, between January 2014 and January 2022, mpMRI of the prostate and subsequent prostate biopsy will identified. All mpMRI images will be retrospectively collected and evaluated using the Quantib Prostate software. In particular, 200 mpMRI with endorectal coil will be read by the expert radiologist and by the Quantib prostate (Quantib B.V. Rotterdam, The Netherlands) software, thus evaluating the predictive characteristics of Quantib Prostate for the identification of suspicious lesions. The sensitivity, specificity, negative predictive value, positive predictive value and accuracy of Quantib Prostate vs. radiologist in detecting csPCa will be evaluated using the biopsy report as reference standard. conditions: Prostate Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ACTUAL name: Quantib prostate (Quantib B.V. Rotterdam, The Netherlands) software measure: To evaluate the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in detecting csPCa of Quantib Prostate vs. traditional radiologist reading of mpMRI measure: To assess the impact of Quantib Prostate in predicting pathologic outcomes in patients who received radical prostatectomy measure: To report time reduction in the diagnosis of suspicious PCa sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Ospedale San Raffaele city: Milan state: MI zip: 20132 country: Italy lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06298292 id: ZerominisCT01 briefTitle: Acceptability/Tolerance of Protein Substitutes in Tablet Form for the Dietary Management of Rare Aminoacidopathies acronym: ZeroMinisMR overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-03-31 date: 2026-06-30 date: 2024-03-07 date: 2024-03-07 name: metaX Institut fuer Diatetik GmbH class: INDUSTRY name: Birmingham Women's and Children's NHS Foundation Trust name: Great Ormond Street Hospital for Children NHS Foundation Trust briefSummary: The purpose of this prospective, observational study is to evaluate the tolerability and acceptability of Zero minis, a range of protein substitute tablets for use in the dietary management of children with either TYROSINAEMIA Type I, II, III or ALKAPTONURIA, HOMOCYSTINURIA, or MAPLE SYRUP URINE DISEASE (MSUD) over the age of 7 years. conditions: Tyrosinemia, Type I conditions: Tyrosinemia, Type II conditions: Tyrosinemia, Type III conditions: Alkaptonuria conditions: Homocystine; Metabolic Disorder conditions: MSUD (Maple Syrup Urine Disease) studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 15 type: ESTIMATED name: Zero minis (range of protein substitutes in tablet form) measure: Daily compliance measure: Treatment-Emergent tolerability measure: Patient Acceptability measure: Metabolic control measure: Incidence of study product emergent events. sex: ALL minimumAge: 7 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06298279 id: 2023-436 briefTitle: Assessing Social Learning and Course Delivery Timing in Internet-delivered Cognitive Behaviour Therapy for Public Safety Personnel overallStatus: NOT_YET_RECRUITING date: 2024-03-12 date: 2025-04-30 date: 2025-04-30 date: 2024-03-07 date: 2024-03-07 name: University of Regina class: OTHER name: Government of Canada briefSummary: This study is a randomized factorial trial designed to evaluate unguided (i.e., purely self-help), transdiagnostic internet delivered cognitive behaviour therapy tailored for public safety personnel with tunneled of personalized course delivery and with or without the incorporation of social learning resources. conditions: Depression conditions: Anxiety conditions: Stress Disorders, Post-Traumatic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL interventionModelDescription: Factor 1: Tunneled or Personalized Course Delivery Factor 2: Standard or Enhanced Social Learning Resources Participants will be randomly assigned to one of four treatment conditions (tunneled delivery of ICBT with standard resources, tunneled delivery of ICBT with enhanced social learning resources, personalized delivery ICBT with standard resources, personalized delivery of ICBT with enhanced social learning resources) primaryPurpose: TREATMENT masking: NONE maskingDescription: Participants cannot be blinded to condition because ICBT (like other psychotherapies) cannot be both provided to and concealed from a participant. However, the difference between the four conditions (i.e., presence or absence of social learning resources, tunneled versus personalized course navigation) will be concealed from all participants. Because outcomes will be assessed via self-report questionnaire measures, outcomes assessor masking is not applicable. count: 164 type: ESTIMATED name: Tunneled Delivery name: Personalized Delivery name: Standard Resources name: Enhanced Social Learning Resources name: Transdiagnostic Self-Guided ICBT measure: Generalized Anxiety Disorder 7-item (GAD-7) measure: Patient Health Questionnaire-9 (PHQ-9) measure: PTSD Checklist for the DSM-5 (PCL-5) measure: Engagement measure: Work and Social Adjustment Scale (WSAS) measure: Brief Resilience Scale (BRS) measure: Healthcare Use Questionnaire measure: Case Story Questionnaire measure: Treatment Satisfaction Questionnaire measure: Digital Behavior Change Interventions Engagement Scale (DCBI) measure: Post-treatment Semi-structured interview sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Psychology, University of Regina city: Regina state: Saskatchewan zip: S4S 0A2 country: Canada name: Heather D Hadjistavropoulos, PhD role: CONTACT phone: 306-585-5133 email: heather.hadjistavropoulos@uregina.ca name: Caeleigh A Landry, MSc role: CONTACT phone: 306-337-2473 email: caeleigh.landry@uregina.ca name: Heather D Hadjistavropoulos, PhD role: PRINCIPAL_INVESTIGATOR lat: 50.45008 lon: -104.6178 hasResults: False
nctId: NCT06298266 id: GD2H-XYK-001 briefTitle: To Assess Safety, Tolerability, and Efficacy of Anti-GPRC5D-CD19-CAR-T in Relapsed/Refractory Multiple Myeloma overallStatus: NOT_YET_RECRUITING date: 2024-03-29 date: 2026-05-31 date: 2026-12-31 date: 2024-03-07 date: 2024-03-07 name: Guangdong Second Provincial General Hospital class: OTHER briefSummary: To evaluate the safety and tolerability of anti-GPRC5D-CD19 CAR-T cells infusion in subjects with relapsed and refractory multiple myeloma conditions: Relapsed or Refractory Multiple Myeloma studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 15 type: ESTIMATED name: infusion of GPRC5D-CD19 CAR T injection measure: Objective Response Rate sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Guangdong Second Provincial General Hospital city: Guangzhou state: Guangdong zip: 510317 country: China name: Qing Zhang role: CONTACT phone: +862089169186 email: zhqing@vip.163.com lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06298253 id: 2024P000832 briefTitle: Behavioral Economics to Implement a Traffic Light Nutrition Ranking System: Study 2 acronym: BeWell overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2027-06 date: 2028-06 date: 2024-03-07 date: 2024-04-09 name: Massachusetts General Hospital class: OTHER briefSummary: This is a cluster randomized controlled trial of 30 food pantries affiliated with the Greater Boston Food Bank to test the use of behavioral economics (BE) tools to encourage food pantries to implement the Supporting Wellness at Pantries (SWAP) program, with the goal of fostering accurate use of SWAP traffic light labels on pantry shelves and increasing the healthfulness of foods chosen by pantry clients. Primary outcomes will be assessed at 6 and 12 months to compare the implementation and effectiveness of the SWAP program in the intervention vs. control pantries. conditions: Food Insecurity conditions: Implementation Science conditions: Diet, Healthy conditions: Behavioral Economics studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 3750 type: ESTIMATED name: Behavioral economics-enhanced SWAP implementation name: Basic SWAP implementation measure: Pantry SWAP implementation measure: Percent items (by weight) ordered by pantry that are labeled green or red measure: Percent of pantry clients' selected food that is green or red measure: Client dietary quality score measure: Skin carotenoid level sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06298240 id: 4R22/074 briefTitle: Implementation of Nursing Demand Management as a Factor for Improvement in a Primary Care Emergency Center. overallStatus: ACTIVE_NOT_RECRUITING date: 2022-10-01 date: 2024-01-05 date: 2024-09-01 date: 2024-03-07 date: 2024-04-15 name: Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina class: OTHER briefSummary: Background: Nurse Demand Management was born in 2009 out of the need to address the growth of spontaneous acute demand in primary care. But it is not until 2013 that guidelines for the exercise of nursing actions in demand management were established in Catalonia, Spain. Nurses trained specifically to solve acute and low complexity health problems generate a quality of care comparable to that provided by family medicine doctors. On the other hand, it is worth highlighting the need to rationalise medical resources in primary care centres, primary care emergency centres or points of continuous care (different emergency facilities in the territory in terms of size and services) in order to give priority to doctors being able to dedicate more time to medium or high complexity pathology. Although nurse demand management has been implemented in primary care teams for years, it is being carried out in different intensities according to the needs or priorities of each health territory.
Hypothesis: The implementation of nurse demand management is a factor of improvement in the efficiency and quality of care in the Primary Care Emergency Centre of the city of Mataró (Barcelona, Spain). Objectives: The main objective of this study was to determine whether the implementation of nurse demand management is a factor in improving efficiency and quality of care in the CUAP of Mataró. Methodology: Non-randomised controlled experimental intervention study. Application of a consensual guide with 5 reasons for health consultations where demand management nursing can be applied. conditions: Nurse's Role conditions: Disease, Acute studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 312 type: ACTUAL name: nursing procedure for acute health problems of low complexity measure: Waiting time and resolution of the visit measure: Number of reconsultations measure: patient experience measure: Prescribed drugs measure: Processed labour disabilities measure: Diagnoses change sex: ALL minimumAge: 16 Years maximumAge: 65 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Mataró primary care emergency center city: Mataró state: Barcelona zip: 08301 country: Spain lat: 41.54211 lon: 2.4445 hasResults: False
nctId: NCT06298227 id: Medipol Hospital 1 briefTitle: Erector Spinae Plane Block vs Quadratus Lumborum Block for Laparoscopic Nephrectomy overallStatus: RECRUITING date: 2024-03-11 date: 2024-07-20 date: 2024-07-30 date: 2024-03-07 date: 2024-03-15 name: Istanbul Medipol University Hospital class: OTHER briefSummary: Ultrasound (US) guided Quadratus Lumborum Block (QLB) is performed at the level of the 12th rib, in the parasagittal oblique plane, at the L1-L2 level. As there are modifications of the block generally local anesthetic is given between quadratus lumborum (QL) and psoas major (PM) muscles (Anterior QLB). The QLB provides a sensory block between T7 - L1. Therefore, QLBs are used to provide postoperative analgesia for abdominal, obstetric, gynecologic, and urologic surgeries.
US-guided erector spinae plane block (ESPB) is performed at the level of the T11 transverse process. After visualization of the erector spinae (ES) muscle and the transverse process, local anesthetic is injected under the ES muscle. ESPB provides a sensory block of the anterior, posterior, and lateral thoracic and abdominal walls accordingly it's used for postoperative analgesia after thoracal wall repairs, thoracotomies, percutaneous nephrolithotomies, nephrectomies, and ventral hernia repairs.
This study aims to compare the effectiveness of US-guided ESPB and QLB on postoperative pain control after laparoscopic nephrectomy. conditions: Kidney Diseases conditions: Kidney Failure studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Sixty patients aged 18-65 years old with American Society of Anesthesiologists (ASA) classification I-II and scheduled for laparoscopic nephrectomy surgery will be included in the study. Patients will be randomly divided into two groups (Group ESPB = ESPB group, Group QLB = QLB group) including 30 patients each, before entering the operating room. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Outcomes assessor and participants will be blinded to the study whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Postoperative analgesia management with Paracerol® and IV PCA with Talinat® name: Erector spinae plane block name: Quadratus lumborum plane block measure: Amount of total opioid consumption (Fentanyl PCA) at the first 24 hours period postoperatively measure: Pain scores (Numerical rating scale-NRS) measure: Need for rescue analgesia (meperidine) measure: Adverse events sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istanbul Medipol University Mega Hospital Complex status: RECRUITING city: Istanbul state: Bağcılar country: Turkey name: Ayşe İnce, Assist Prof role: CONTACT lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06298214 id: RP-23-019 briefTitle: Testing the Effectiveness of the Her Health Program to Add Healthcare Value in the Fourth Trimester acronym: Her Health overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-01-01 date: 2026-06-01 date: 2024-03-07 date: 2024-03-07 name: Elizabeth F Sutton, PhD class: OTHER name: Donaghue Medical Research Foundation briefSummary: The goal of this clinical trial is to learn if a program Woman's Hospital has made, called the Her Health Program, can help women be healthy and get healthcare in the first year after having a baby.
Researchers will compare those who receive the Her Health Program and those who do not receive the program to see if the Her Health Program can help women get healthcare in the first year after having a baby. conditions: Postpartum conditions: Pregnancy Related studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 500 type: ESTIMATED name: Her Health Program measure: Postpartum visit attendance measure: Medical trust measure: Health literacy measure: Self-efficacy measure: Healthcare costs sex: FEMALE minimumAge: 16 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Woman's Hospital city: Baton Rouge state: Louisiana zip: 70817 country: United States lat: 30.45075 lon: -91.15455 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-12-05 uploadDate: 2024-02-02T12:19 filename: Prot_SAP_000.pdf size: 458232 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-12-06 uploadDate: 2024-02-02T12:21 filename: ICF_001.pdf size: 188057 hasResults: False
nctId: NCT06298201 id: IMAGINE2024 briefTitle: E-Based Physical Exercise in Patients With Multiple Sclerosis and Comorbidity acronym: COMPACT overallStatus: RECRUITING date: 2024-04 date: 2024-11 date: 2025-07 date: 2024-03-07 date: 2024-03-07 name: University of Southern Denmark class: OTHER briefSummary: Background: Physical exercise (PE) improves symptoms and quality of life in patients with multiple sclerosis (pwMS). Comorbidity is prevalent among pwMS and may contribute to disease progression. Integrating and sustaining PE is challenging and E-based PE solutions have been proposed as a tool to support the integration of PE into daily life.