hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06268366 id: UEvansville briefTitle: Effects of Exercise-Based Interventions on Symmio Self-Movement Screen overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-08-01 date: 2025-03-01 date: 2024-02-20 date: 2024-02-29 name: University of Evansville class: OTHER briefSummary: Musculoskeletal screening for physical risk factors requires equipment and a trained healthcare or fitness professional to perform and interpret the scoring so that appropriate exercise interventions can be prescribed. However, barriers such as healthcare costs and accessibility, low perceived need to seek medical care, and previous unfavorable evaluation of seeking medical care are associated with healthcare avoidant behaviors. This research aims to explore the effectiveness of the Symmio Self-Screen application to generate specific exercise interventions to address an individual's associated physical risk factors. The ability of the Symmio application to prescribe a targeted exercise program which can reduce asymmetries, improve movement quality, and enhance overall function is unknown. Therefore, the purpose of this study is to determine the effectiveness of the Symmio application in designing individualized exercise interventions which target the unique movement limitations and asymmetries in adults. conditions: Movement Disorders studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The primary investigators and statisticians will be blinded to the group allocation whoMasked: OUTCOMES_ASSESSOR count: 180 type: ESTIMATED name: Exercise measure: Symmio Self-Movement Screen measure: Global Rating of Change sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06268353 id: 109324-1 briefTitle: Is the Plasma Concentration of CAPGDF15 Increased in Pregnancy? A Pilot Study acronym: CAP overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2026-03-15 date: 2026-03-15 date: 2024-02-20 date: 2024-02-26 name: University of Copenhagen class: OTHER name: Stanford University briefSummary: Background and Purpose During pregnancy, the hormone GDF15 rises between 100-200 times higher than before pregnancy. The significance of this dramatic increase is not clarified, but it has been shown that pregnant women with insufficient increase in GDF15 have a higher risk of spontaneous abortion. CAPGDF15 is a small peptide consisting of 12 amino acids recently found in plasma in both mice and humans, and this peptide is part of the prohormone from which GDF15 is synthesized. Therefore, the assumption is that CAPGDF15 is secreted simultaneously with GDF15. The significance of CAPGDF15 in the organism is completely unknown, except that injection into mice reduces food intake. Therefore, the investigators are interested in investigating whether there is a similar dramatic upregulation of CAPGDF15 as with GDF15 itself. The investigators will not set up a large-scale study without having some prior knowledge of whether this is indeed the case. Therefore, the investigators will conduct a pilot study on 3 pregnant women and 3 control women to examine whether there is any reason to proceed with an actual scientific experiment. Since the increase in GDF15 itself is very large at least100 fold, a pilot study involving only 3 pregnant women and 3 non-pregnant women will be sufficient to gain an impression of whether there is also a significant increase in CAPGDF15. The data will be used to assess whether an actual research project is worth establishing.
The purpose of conducting this pilot study is to investigate whether there is an upregulation of CAPGDF15 similar to that of the hormone GDF15 during pregnancy. By conducting a pilot study on 3 pregnant women and 3 control women, the investigators will see if this is actually the case before setting up an actual scientific experiment. conditions: Pregnancy Related studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SEQUENTIAL interventionModelDescription: Non-pregnant controls and pregnant women primaryPurpose: BASIC_SCIENCE masking: NONE count: 6 type: ESTIMATED name: blood sampling measure: CAPGDF15 levels in plasma sex: FEMALE minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT hasResults: False
nctId: NCT06268340 id: ABIntl-23-25 briefTitle: Hearing and Structure Preservation Via ECochG acronym: PRESERVE overallStatus: NOT_YET_RECRUITING date: 2024-02-29 date: 2026-06-30 date: 2026-06-30 date: 2024-02-20 date: 2024-02-20 name: Advanced Bionics AG class: INDUSTRY briefSummary: The goal of the study is to determine the benefit of using an ECochG-based corrective action guide during cochlear implant surgery compared to the traditional surgical approach without ECochG surveillance and guidance. conditions: Hearing Loss, Sensorineural conditions: Severe-to-profound Hearing Loss studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 102 type: ESTIMATED name: ECochG monitored CI surgery incl. corrective action guide name: Routine CI surgery without ECochG monitoring measure: Hearing Preservation measure: Structure Preservation measure: Speech perception measure: Surgeons' feedback sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Universitair Ziekenhuis Gent city: Gent zip: 9000 country: Belgium name: Lara Derycke, Ms role: CONTACT phone: +3293321246 email: Lara.derycke@ugent.be name: Ingeborg Dhooge, Dr role: PRINCIPAL_INVESTIGATOR name: Freya Swinnen, Dr role: PRINCIPAL_INVESTIGATOR lat: 51.05 lon: 3.71667 facility: Le Centre Hospitalier Régional Universitaire de Tours city: Tours zip: 37000 country: France name: Mme Nollet role: CONTACT email: promotions.externes@chu-tours.fr name: David Bakhos, Prof role: PRINCIPAL_INVESTIGATOR name: Mathieu Robier, Mr role: PRINCIPAL_INVESTIGATOR lat: 47.38333 lon: 0.68333 facility: Universitätsklinikum Freiburg Klinik city: Freiburg zip: 79106 country: Germany name: Claudia Greulich, Ms role: CONTACT email: claudia.greulich@uniklinik-freiburg.de name: Antje Aschendorff, Prof role: PRINCIPAL_INVESTIGATOR name: Thomas Wesarg, Dr role: PRINCIPAL_INVESTIGATOR lat: 47.9959 lon: 7.85222 facility: Ospedale Martini city: Torino state: TO zip: 10141 country: Italy name: Diego Di Lisi, Dr role: PRINCIPAL_INVESTIGATOR name: Patrizia Consolino, Dr role: PRINCIPAL_INVESTIGATOR lat: 45.07049 lon: 7.68682 facility: World Hearing Center city: Warsaw state: Nadarzyn zip: 05-830 country: Poland name: Iwona Tomaszewska-Hert, Ms role: CONTACT email: i.tomaszewska@csim.home.pl name: Piotr Skarżyński, Prof role: PRINCIPAL_INVESTIGATOR name: Adam Walkowiak, Dr role: PRINCIPAL_INVESTIGATOR lat: 52.22977 lon: 21.01178 facility: Cambridge University Hospitals NHS Foundation Trust city: Cambridge state: England zip: CB2 0QQ country: United Kingdom name: Sophie McKenny, Ms role: CONTACT phone: +441223586625 email: sophie.mckenny@nhs.net name: Matthew E Smith, Dr role: PRINCIPAL_INVESTIGATOR name: Patrick Axon, Dr role: PRINCIPAL_INVESTIGATOR lat: 52.2 lon: 0.11667 hasResults: False
nctId: NCT06268327 id: Adjuvant treatment in BC briefTitle: Adding Adjuvant Cisplatin and Gemicitabine Versus Capecitabine in Triple-negative Breast Cancer Patients in Non pCR After Neoadjuvant Standard Chemotherapy overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2025-10-30 date: 2026-10-30 date: 2024-02-20 date: 2024-02-20 name: Assiut University class: OTHER briefSummary: In our study; investigator aim To show efficacy and toxicity of Adjuvant cisplatin and gemcitabine in triple-negative breast cancer patients with non pathologically complete response after neoadjuvant chemotherapy To compare outcome of adjuvant cisplatin and gemcitabine versus capecitabine conditions: Breast Cancer studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Cisplatin injection and gemcitabine name: Capecitabine tablets measure: Adding adjuvant cisplatin and gemcitabine versus capecitabine in triple-negative Breast cancer patients with non pathologically complete response after neoadjuvant standard chemotherapy measure: Comparison of patients who receive cisplatin and gemcitabine versus capecitabine in Triple negative breast cancer sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06268314 id: hypoalbuminemia in pediatrics. briefTitle: Feeding Pattern and Hypoalbuminemia in Pediatrics With Chronic Kidney Disease. overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-03-01 date: 2026-06-01 date: 2024-02-20 date: 2024-03-05 name: Assiut University class: OTHER briefSummary: To determine the impact of feeding pattern on the development of hypoalbuminemia and out come of pediatric patients with chronic kidney disease. conditions: Chronic Kidney Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 70 type: ESTIMATED measure: Feeding Pattern and Hypoalbuminemia in Pediatrics With Chronic Kidney Disease. sex: ALL minimumAge: 2 Years maximumAge: 16 Years stdAges: CHILD hasResults: False
nctId: NCT06268301 id: TAK-721-1003 briefTitle: A Study to Determine the Effect Food Has on TAK-721 (Budesonide Oral Suspension) in the Body of Healthy Adults overallStatus: COMPLETED date: 2023-02-06 date: 2023-02-17 date: 2023-02-20 date: 2024-02-20 date: 2024-02-20 name: Takeda class: INDUSTRY briefSummary: The main aim of this study is to check what the body of a healthy adult who either fasted or had eaten does to TAK-721 and how TAK-721 is distributed in and removed from the body. Other aims are to learn how safe the treatment with TAK-721 is and how suitable the TAK-721 is for healthy adults who either fasted or had eaten. All participants will receive TAK-721 but half will be assigned by chance to the participant group who are fasting first then getting the high-fat/high-calorie meal later or the group who gets meal first and fasts later. The group assignment will be switched once during the course of the study so that all participants will receive TAK-721 in both a fasted or fed condition. conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 20 type: ACTUAL name: Budesonide measure: Maximum Observed Concentration (Cmax) measure: Area Under the Concentration-time Curve From Time 0 to the Time of the Last Quantifiable Concentration (AUClast) measure: Area Under the Concentration-time Curve From Time 0 to Infinity (AUC∞) measure: Number of Participants who Experience at Least one Treatment Emergent Adverse Event (TEAE) by Severity, Serious Adverse Events (SAE) and Death measure: Number of Participants With Clinically Significant Abnormal Vital Sign Values measure: Number of Participants With Clinically Significant Abnormal Clinical Laboratory Values measure: Area Under the Concentration-time Curve From Time 0 to 12 Hours (AUC0-12) measure: Area Under the Curve From the Last Quantifiable Concentration to Infinity Expressed as a Percentage of AUC∞ (AUCextrap%) measure: Time to First Occurrence of Cmax (tmax) measure: Lag Time to First Quantifiable Concentration (tlag) measure: Terminal Disposition Phase Half-life (t1/2z) measure: Terminal Disposition Phase Rate Constant (λz). measure: Apparent Clearance (CL/F) Calculated Using the Observed Value of the Last Quantifiable Concentration measure: Apparent Volume of Distribution During the Terminal Disposition Phase (Vz/F) Calculated Using the Observed Value of the Last Quantifiable Concentration sex: ALL minimumAge: 19 Years maximumAge: 55 Years stdAges: ADULT facility: Celerion city: Lincoln state: Nebraska zip: 68502 country: United States lat: 40.8 lon: -96.66696 hasResults: False
nctId: NCT06268288 id: 22-011492 briefTitle: Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) overallStatus: NOT_YET_RECRUITING date: 2024-02-12 date: 2024-07-22 date: 2024-12-22 date: 2024-02-20 date: 2024-02-20 name: Mayo Clinic class: OTHER briefSummary: The purpose of this study is to determine if nVNS will decrease autonomic symptom intensity (COMPASS-31 and Child Functional Disability Inventory) in adolescent patients with postural orthostatic tachycardia syndrome (POTS) in comparison to standard recovery STEPS management. conditions: Postural Tachycardia Syndrome conditions: Autonomic Dysfunction conditions: Postural Orthostatic Tachycardia Syndrome conditions: POTS - Postural Orthostatic Tachycardia Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Half of the patient population will be randomized to standard management only. The other half of the population will be randomized to standard management plus use of the vagal nerve stimulator primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: GammaCore intervention name: STEPS management protocol measure: The change in COMPASS-31 scores between individuals in both arms of the study measure: The change in Child Functional Disability Inventory scores between individuals in both arms of the study measure: The change in heart rate increase in head up tilt table tests in individuals in both arms of the study measure: Does nVNS influence headache frequency in adolescent patients with POTS measure: Does nVNS influence ability to increase exercise duration in adolescent patients with POTS measure: Does use of nVNS influence degree of depression in adolescent patients with POTS sex: ALL minimumAge: 12 Years maximumAge: 19 Years stdAges: CHILD stdAges: ADULT facility: Mayo Clinic in Rochester city: Rochester state: Minnesota zip: 55905 country: United States lat: 44.02163 lon: -92.4699 hasResults: False
nctId: NCT06268275 id: HE651314 briefTitle: Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy overallStatus: COMPLETED date: 2022-09-19 date: 2024-02-01 date: 2024-02-13 date: 2024-02-20 date: 2024-02-20 name: Khon Kaen University class: OTHER briefSummary: The goal of this clinical trial is to compare hemodynamic response (MAP, SBP, DBP and HR) between scalp block and intravenous esmolol while skull pins application in patients undergoing elective supratentorial craniotomy under general anesthesia. conditions: Hemodynamic Instability studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: RCT primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 90 type: ACTUAL name: Scalp block name: Esmolol measure: MAP measure: SBP measure: DBP measure: HR measure: BIS measure: Cumulative postoperative opioids consumption measure: Postoperative adverse events sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Khon Kaen University city: Khon Kaen state: Naimuang, Muang zip: 40002 country: Thailand lat: 16.44671 lon: 102.833 hasResults: False
nctId: NCT06268262 id: XYFY2023-KL045-01 briefTitle: Surgical-imaging Research on Obesity (SIRO) overallStatus: RECRUITING date: 2023-03-01 date: 2026-12 date: 2028-12 date: 2024-02-20 date: 2024-03-15 name: The Affiliated Hospital of Xuzhou Medical University class: OTHER briefSummary: The global obesity epidemic is well established, and is an important public health issue. The previous researches had applied the clues that obesity is a kind of systemic disease. The investigators hypothesized that a serious alteration of the body systems will occur after bariatric surgery, which may shed light on the mechanisms of obesity. Thus, the research aims to combine the imaging and surgery to investigate the alterations of the body that induced by obese and alterations after surgery. conditions: Overweight and Obesity studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: Imaging parameters of obesity measure: Imaging parameters of obesity measure: Imaging parameters of obesity measure: Neurotransmitter, inflammatory factors and hormones related to obesity in blood sample measure: Neurotransmitter, inflammatory factors and hormones relating to obesity in blood sample measure: Neurotransmitter, inflammatory factors and hormones related to obesity in blood sample measure: Genetic information from venous blood sample, biopsied liver tissue, biopsied fat tissue, and gastric tissue sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Affiliated Hospital of Xuzhou Medical University status: RECRUITING city: Xuzhou state: Jiangsu zip: 221000 country: China name: Kai Liu, M.D/Ph.D role: CONTACT phone: +86-15920157720 email: liu-k@hotmail.com lat: 34.18045 lon: 117.15707 hasResults: False
nctId: NCT06268249 id: TJ-IRB20231224 briefTitle: Ulinastatin Improves Post-Cardiac Surgery Cognitive Dysfunction overallStatus: COMPLETED date: 2015-01-01 date: 2022-12-30 date: 2023-12-30 date: 2024-02-20 date: 2024-02-20 name: Qin Zhang class: OTHER briefSummary: This study is a retrospective, observational study that aims to include patients undergoing cardiac surgery. 1. Evaluate the preventive effect of ursodeoxycholic acid on post-cardiac surgery cognitive dysfunction over the past eight years. 2. Utilize the pre-existing preoperative and postoperative 24-hour plasma samples from previous studies to measure the levels of glycocalyx and its related regulatory factors. 3. Assess the clinical correlation between the measured parameters and patient outcomes. conditions: Cardiac Complication studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 7065 type: ACTUAL name: Ulinastatin measure: POCD - Postoperative Cognitive Dysfunction measure: Survival time sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology city: Wuhan state: Hubei zip: 430030 country: China lat: 30.58333 lon: 114.26667 hasResults: False
nctId: NCT06268236 id: BF2023-252 briefTitle: Electro-acupuncture to Treat Disorder of Consciousness overallStatus: RECRUITING date: 2024-01-01 date: 2026-01-31 date: 2026-01-31 date: 2024-02-20 date: 2024-02-20 name: The Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine class: OTHER briefSummary: With the rapid development of life support technology, more and more people can survive severe brain injury. Some survivors regain consciousness after a period of coma, however, many patients develop prolonged disorders of consciousness (DOC), which poses a therapeutic challenge for clinicians and a heavy burden for their families. The investigators design an Electro-acupuncture to treat disorder of consciousness (AcuDoc) trial with the aim of validating the clinical effect of electroacupuncture in treating DOC and exploring its therapeutic mechanisms by integrating EEG, neuroimaging, evoked potential tests, and behavioral assessments. conditions: Disorder of Consciousness conditions: Electroacupuncture studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Electroacupuncture name: Sham electroacupuncture measure: Coma Recovery Scale - Revised score measure: phase locking value measure: amplitude of low-frequency fluctuation measure: Amide proton transfer-weighted signal measure: f value measure: neurite density index measure: latency value of N20 measure: latency between III and V potentials measure: Glasgow Outcome Scale-Extended score measure: Glasgow Outcome Scale-Extended score measure: brain-computer interface accuracy sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine status: RECRUITING city: Guangzhou state: Guangdong zip: 510120 country: China name: Fang Yuan, PhD role: CONTACT phone: +86-20-81887233 email: plawlx@gzucm.edu.cn lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06268223 id: 2023/315 briefTitle: Home-Based Action Observation Training for Chewing and Swallowing Function overallStatus: RECRUITING date: 2023-10-13 date: 2024-05-01 date: 2024-07-01 date: 2024-02-20 date: 2024-02-20 name: Ondokuz Mayıs University class: OTHER name: Hacettepe University briefSummary: The goal of this clinical trial is to investigate the effects of home-based Action Observation Training (AOT) applied together with Functional Chewing Training (FuCT) on chewing and swallowing functions and feeding behavior in children with Cerebral Palsy (CP) who have chewing disorders. The main questions it aims to answer are:
* Is the application of Home-Based AOT together with FuCT effective on feeding behavior in children with CP? Within the scope of the study, children with CP will be divided into two groups as the study group and the control group. All groups will implement FuCT routines, comprising 5 sets per day, 5 days a week, for 12 weeks. Additionally, the study group will be included in an AOT program, conducted via telerehabilitation, for 1 set per day, 3 days a week, for 12 weeks, with the guidance of a physiotherapist. All children with CP will be evaluated at the beginning, after 6 weeks, and at the end of the study. conditions: Cerebral Palsy conditions: Chewing Disease conditions: Action Obervation Training studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: Chewing Exercise Training measure: Karaduman Chewing Performance Scale measure: Turkish version of the Mastication Observation and Evaluation Instrument measure: Test of Masticating and Swallowing Solids in Children measure: Nutrient consistency according toInternational Dysphagia Diet Standardisation Initiative measure: The Pediatric version of the Eating Assessment Tool measure: Dysphagia Disorder Survey measure: Behavioral Pediatrics Feeding Assessment Scale sex: ALL minimumAge: 6 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Seda Nur Kemer,PT, MSc,PhD Candidate, Lecturer status: RECRUITING city: Samsun state: Atakum zip: 55200 country: Turkey name: Seda Nur Kemer, 1 role: CONTACT phone: +9005467861866 email: sedakemer@gmail.com lat: 41.27976 lon: 36.3361 hasResults: False