hackint0sh/New-Dataset huggingface dataset:
3. Explore physical activity measures subjectively and objectively. Exploratory outcomes include pre and post Timed Up and Go test, patient reported outcome surveys and activity as measured by wearable devices. conditions: Stroke, Acute Ischemic studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 30 type: ESTIMATED name: CATCHES measure: Percentage of intervention completers to demonstrate feasibility measure: Change in Activities-specific Balance Confidence Scale Score measure: Timed Up and Go Test Score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Neurological Institute of New York, Columbia University city: New York state: New York zip: 10032 country: United States name: Carmen Castillo role: CONTACT phone: 212-305-7755 email: cec34@cumc.columbia.edu name: Imama Naqvi, MD role: CONTACT email: ian2108@cumc.columbia.edu name: Imama A. Naqvi, MD role: PRINCIPAL_INVESTIGATOR name: Lori Quinn, PhD role: SUB_INVESTIGATOR name: Olajide A Williams, MD, MS role: SUB_INVESTIGATOR lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06314295 id: BeijingH-WF briefTitle: Automated Echocardiographic Detection of Coronary Artery Disease Using Artificial Intelligence Methods overallStatus: NOT_YET_RECRUITING date: 2024-03-11 date: 2026-03-11 date: 2026-04-11 date: 2024-03-18 date: 2024-03-18 name: Beijing Hospital class: OTHER_GOV briefSummary: The incidence rate and mortality of coronary artery disease are increasing year by year. Exploring non-invasive, accurate, and widely applicable methods to screen and diagnosis is of great significance. New ultrasound techniques, such as non-invasive myocardial work, have been proven to be superior to traditional ultrasound techniques in screening and diagnosis. However, diagnostic analysis based on ultrasound video images is time-consuming and subjective. The progress of artificial intelligence technology in fully automated quantitative evaluation of video images provides the possibility for computer-aided design screening and diagnosis. At present, the application of artificial intelligence in computer-aided design is a cutting-edge issue in the field of cardiovascular disease research. The application of artificial intelligence technology in the construction of computer-aided diagnostic models based on ultrasound video images is still in its early stages. conditions: Coronary Artery Disease studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 1500 type: ESTIMATED measure: Different coronary angiography results sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06314282 id: D3461R00072 briefTitle: INTERSTELLAR - International Study Evaluating Lupus Outcomes After Anifrolumab Real World Use acronym: INTERSTELLAR overallStatus: NOT_YET_RECRUITING date: 2024-06-30 date: 2027-08-31 date: 2027-08-31 date: 2024-03-18 date: 2024-03-18 name: AstraZeneca class: INDUSTRY briefSummary: INTERSTELLAR study will generate critical prospective real-world evidence on the benefits of adding Anifrolumab to standard of care treatment for SLE in routine clinical practice, to inform physicians, payers and patients. The study will use clinical assessments that are relevant for SLE-treating physicians in routine clinical practice, as well as introduce a specific measure for skin manifestations to affirm the potency of anifrolumab in treating SLE-related skin manifestations. The study will use standardized objectives, inclusion/exclusion criteria and outcome measures across all countries participating in this study including GCC (Qatar, KSA), Mexico, CAMCAR (Costa Rica, Panama, Dominican Republic), Colombia, Argentina, Taiwan, and Egypt, and any other countries that may be included in the study, in order to facilitate a comparison and analysis across all countries included in this study. conditions: Systemic Lupus Erythematosus (SLE) studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: PGA measure: SLEDAI-2K measure: CLASI measure: FACIT-Fatigue measure: LupusQoL measure: EQ-5D-5L sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06314269 id: 246810121416 briefTitle: Incidence of Perioperative Cerebrovascular Stroke in Assuit University Hospitals , Hospital Based Study overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-03-31 date: 2025-09-30 date: 2024-03-18 date: 2024-03-20 name: Assiut University class: OTHER briefSummary: Stroke is the most common cause of disability in elderly people (over 65years of age) and the third most common cause of death in the world . The World Health Organization estimates that one in six people globally will suffer from stroke in their lifetime.
Perioperative stroke is the most unwanted complication for patients, as well as for surgeons and anesthesiologists . The reported risk of perioperative stroke varies with the type of surgery. Its incidence is generally not high (approximate 0.1-1.9%) in non-cardiac, non-neurologic, and non-major surgery However, it may occur in up to 10% of patients undergoing high-risk cardiac or brain surgery . Patients with perioperative stroke are less likely to have a good functional outcome and have an eight-fold higher mortality compared with those without perioperative stroke conditions: Perioperative Complication studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 1 type: ESTIMATED measure: 1- To determine incidence and prevalence of perioperative cerebrvosacular stroke in General surgery, cardiothorasic surgery and vascular surgery departments , Assuit university hospitalis , Egypt. sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06314256 id: 2023/218 briefTitle: Clinical Evaluation of Hyaluronic Acid and Platelet Rich Fibrin Injection Efficacy in Interdental Papilla Reconstruction overallStatus: RECRUITING date: 2024-04-10 date: 2024-10-10 date: 2024-11-10 date: 2024-03-18 date: 2024-03-18 name: Altinbas University class: OTHER briefSummary: The goal of this clinical trial is to evaluate and compare the efficacy of injectable platelet rich fibrin (i-PRF) and hyaluronic acid (HA) in reconstruction of interdental papilla loss. The main questions it aims to answer are:
* Which treatment option is better accepted by patients? Which treatment option would patients be more satisfied with? Participants with multiple interdental papilla loss will be treated with both i-PRF and HA in split-mouth design. Researchers will compare two treatment options to see if black triangles caused by interdental papilla loss closes and if yes, for how long do they last. conditions: Interdental Papilla Loss studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A type of study used frequently in oral research: the mouth is divided into two or more subunits. Active and control (comparison) treatments are applied to the subunits (e.g., to the left and right sides). primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Participant will be masked which side of her/his mouth treated with either i-PRF or HA. whoMasked: PARTICIPANT count: 15 type: ESTIMATED name: Injection name: Injection measure: Reduction in Black Triangle Area measure: Reduction in Black Triangle Height measure: Reduction in Black Triangle Width measure: Volume Gain of Interdental Papilla measure: Patient Satisfaction Score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Altinbas University status: RECRUITING city: Istanbul country: Turkey name: Baris Impram role: CONTACT phone: +905343148500 email: barisimpram@gmail.com lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06314243 id: RHDIRB2020110301 REC #241 briefTitle: The Impact of Pumpkin Seed Oil Supplementation on Hemodialysis Patients overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-08 date: 2025-05 date: 2024-03-18 date: 2024-03-18 name: Ain Shams University class: OTHER briefSummary: The goal of this clinical trial is to investigate the effects of Pumpkin Seed Oil (PSO) supplementation on systemic inflammation, oxidative stress, and lipid profile in hemodialysis patients.
* Group 2 (Control group): consists of 28 patients who will not receive the intervention. primaryPurpose: TREATMENT masking: NONE count: 56 type: ESTIMATED name: Pumpkin Seed Oil " Ronkin®, KMT PHARMA, Egypt. " measure: To evaluate the effect of PSO supplementation on oxidative stress in hemodialysis patients. measure: To evaluate the effect of PSO supplementation on the systemic inflammation in hemodialysis patients. measure: To evaluate the effect of PSO supplementation on the lipid profile in hemodialysis patients. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06314230 id: AUSCAD briefTitle: Australian Genomics Of Chronic Allograft Dysfunction Study acronym: AUSCAD overallStatus: RECRUITING date: 2012-04-26 date: 2040-01-01 date: 2040-01-01 date: 2024-03-15 date: 2024-04-10 name: Western Sydney Local Health District class: OTHER briefSummary: The goal of the Australian Genomics of Chronic Allograft Dysfunction (AUSCAD) study is a single centre (Westmead Hospital), prospective, observational study, which enrols patients at time of kidney (or kidney-transplant) transplant and tracks the post transplant course. The AUSCAD study aims to generate new knowledge and improve outcomes following kidney transplantation. The primary aim is to determine whether important outcomes (including chronic rejection and graft loss) are correlated with patterns of allograft reactivity, gene expression and susceptibility profiles. conditions: Kidney Transplant Rejection conditions: Kidney Transplant; Complications studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 500 type: ESTIMATED measure: Graft failure measure: Allograft rejection measure: Gene profile measure: Death measure: Major infectious adverse outcomes measure: Major malignancy related adverse outcomes measure: Major cardiovascular adverse outcomes measure: Chronic allograft dysfunction measure: BK virus associated nephropathy measure: Albuminuria measure: Surrogate end-points measure: Delayed graft function (DGF) measure: Death censored graft loss (DCGL) measure: Treatment resistant rejection sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Westmead Hospital status: RECRUITING city: Westmead state: New South Wales zip: 2145 country: Australia name: Jennifer SY Li, MBBS, FRACP role: CONTACT email: jennifer.li@health.nsw.gov.au lat: -33.80383 lon: 150.98768 facility: Westmead Institute for Medical Research status: RECRUITING city: Westmead state: New South Wales zip: 2145 country: Australia name: Philip J O'Connell, MBBS, FRACP role: CONTACT email: philip.oconnell@sydney.edu.au lat: -33.80383 lon: 150.98768 hasResults: False
nctId: NCT06314217 id: CL-00002 id: 202330714 type: REGISTRY domain: MOH ISRAEL briefTitle: Everads Injector in Suprachoroidal Administration of TA Suspension, for Treatment of Patients With DME overallStatus: RECRUITING date: 2024-02-18 date: 2024-12-30 date: 2025-03-30 date: 2024-03-15 date: 2024-03-15 name: Everads Therapy class: INDUSTRY briefSummary: This is an open-label pilot device study. The aim of the study is to evaluate the safety and performance of Everads Injector following single injection of suspension approved for ocular use into the suprachoroidal space.
The study will involve 6 visits during a period of 6 weeks conditions: Diabetic Macular Edema studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Everads Injector: For targeted suprachoroidal delivery of therapy primaryPurpose: OTHER masking: NONE count: 10 type: ESTIMATED name: Everads Injector measure: Frequency of treatment-emergent adverse events measure: Frequency of adverse device effects measure: Confirmation of TA delivery into the suprachoroidal space measure: Change from baseline in central macular thickness sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Rambam MC status: RECRUITING city: Haifa country: Israel name: Meital Abecassis role: CONTACT phone: 047772668 name: Yoreh Barak, MD role: PRINCIPAL_INVESTIGATOR lat: 32.81841 lon: 34.9885 hasResults: False
nctId: NCT06314204 id: 2015-A01222-47 briefTitle: Impact of Cannabis Consumption on the Course, Modalities of Hospitalization and the Short-term Prognosis of Inpatients Suffering From Psychotic Symptoms acronym: canhope overallStatus: RECRUITING date: 2016-09-20 date: 2025-09-06 date: 2026-09-06 date: 2024-03-15 date: 2024-03-15 name: Centre hospitalier de Ville-Evrard, France class: OTHER briefSummary: Few studies have evaluated, in patients with symptomatology the impact of cannabis use on the duration of hospitalization and on short- and medium-term developments. The objective of this study will be to assess the impact of cannabis on the duration, the hospitalization and the short- and medium-term evolution of patients with psychotic symptoms and cannabis use. We hypothesize that these patients (in comparison with patients with psychotic symptomatology and not using cannabis) would be hospitalized more long, exposed to a higher risk of resistance to the usual therapeutics, would have a lack of therapeutic alliance and insight, relapses and hospitalizations more frequent, more marked negative symptoms and lower quality remission. They would also be more prone to impulsive and aggressive behaviour. conditions: Psychotic; Disorder, Cannabis studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: PANSS: Positive and Negative Syndrom Scale measure: PANSS: Positive and Negative Syndrom Scale measure: PANSS: Positive and Negative Syndrom Scale measure: PANSS: Positive and Negative Syndrom Scale measure: MCQ-SF :Marijuana Craving Questionnaire- Short Form measure: MCQ-SF :Marijuana Craving Questionnaire- Short Form) measure: MCQ-SF :Marijuana Craving Questionnaire- Short Form) measure: MCQ-SF :Marijuana Craving Questionnaire- Short Form) measure: CGI: Clinical Global Impression measure: CGI: Clinical Global Impression measure: CGI: Clinical Global Impression measure: CGI: Clinical Global Impression measure: MADRS: Montgomery Åsberg Depression Rating Scale measure: MADRS: Montgomery Åsberg Depression Rating Scale measure: MADRS: Montgomery Åsberg Depression Rating Scale measure: MADRS: Montgomery Åsberg Depression Rating Scale measure: PDS: Psychotic Depression Scale measure: PDS: Psychotic Depression Scale measure: PDS: Psychotic Depression Scale measure: PDS: Psychotic Depression Scale measure: YMRS: Young Mania Rating Scale measure: YMRS: Young Mania Rating Scale measure: YMRS: Young Mania Rating Scale measure: YMRS: Young Mania Rating Scale measure: CDS: Self-Consciousness Revised Scale measure: CTQ: Childhood Trauma Questionnaire measure: BFI: Big Five Inventory sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: unité de recherche clinique de l'E.P.S de Ville Evrard status: RECRUITING city: Neuilly Sur Marne zip: 93332 country: France name: Rusheenthira THAVASEELAN, Msc role: CONTACT phone: 0143093232 email: r.thavaseelan@epsve.fr lat: 48.85373 lon: 2.54903 hasResults: False
nctId: NCT06314191 id: 23-AOIP-02 briefTitle: Adipose Tissue and Symptomatic Gonarthrosis acronym: TAGS overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2025-04-15 date: 2025-09-15 date: 2024-03-15 date: 2024-03-15 name: Centre Hospitalier Universitaire de Nice class: OTHER briefSummary: 1. Prevalence of osteoarthritis in France Osteoarthritis (OA) is a very common disease, affecting almost 15% of the population. It is responsible for a significant socio-economic cost in connection with the chronic and disabling pain it causes . Gonarthrosis is the most frequently encountered arthritic localization . In a large 2010 meta-analysis, the main risk factors for developing knee OA were shown to be obesity, previous knee trauma, hand OA, female gender and advanced age. Smoking appeared to have a moderate protective effect . The risk of developing gonarthrosis in obese patients is 2.6 times higher than in the general population. Hypercholesterolemia itself is a risk factor for osteoarthritis, as are increased plasma levels of specific fatty acids and lipoproteins Inflammatory mechanism in osteoarthritis. Studies have shown that plasma levels of C-reactive protein, can be used to estimate individual susceptibility to developing osteoarthritis over a lifetime . In osteoarthritis patients, plasma concentrations of TNF-α, IL-6 and IL-1 are abnormally high, which appears to contribute to cartilage loss in these subjects .
3. Inflammatory mechanism in obesity. Obesity induces systemic and local joint mechanical stresses that increase the risk of developing gonarthrosis in obese or overweight individuals . Beyond the simple mechanical aspect, a body of evidence supports the assertion that obesity is responsible for a systemic inflammatory state, deleterious to joints. 1) Obesity is associated with radiographic and symptomatic osteoarthritis in non-weight-bearing joints, such as the hand In overweight and obese adults, plasma levels of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) are significantly increased .
4. Common inflammatory mechanisms between adipose tissue and obesity. The relationship between adipose tissue and inflammation is complex given the different types of adipose tissue and the action of cells derived from it. Adipose tissue is an active endocrine organ composed of mature and developing adipocytes, as well as fibroblasts, endothelial cells and a wide range of immune cells, namely adipose tissue macrophages, neutrophils, eosinophils, mast cells, T cells and B cells. Adipose tissue is recognized as an endocrine organ that secretes a large number of inflammatory mediators, including cytokines (IL-1, IL-6, IL-8, TNF-α) and adipokines (leptin, adiponectin, resistin, visfatin). Communication between adipocytes and immune cells maintains tissue homeostasis. Obesity, however, can upset this balance.
White and brown adipose tissue appear to play a complementary role in the development of osteoarthritis. Increased white adipose tissue in obesity is thought to create a systemic environment of increased inflammation through the release of pro-inflammatory cytokines and adipokines such as leptin and visfatin, all of which have been associated with osteoarthritis . Locally, white adipocytes in infra patellar adipose tissue are architecturally different in patients without gonarthrosis compared with those with knee osteoarthritis. This difference suggests that adipocyte gene expression is directly influenced by inflammation . In obese individuals, there is elevated IL-6 production in brown adipose tissue . Furthermore, it would appear that brown adipose tissue, unlike white, down-regulates the inflammatory profile of macrophages . conditions: Gonarthrosis conditions: Obesity studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: NONE count: 20 type: ESTIMATED name: blood sampling name: knee radiography measure: lipolytic activity measure: lipolysis measurement sex: ALL minimumAge: 30 Years maximumAge: 55 Years stdAges: ADULT facility: Nice University Hospital city: Nice zip: 06000 country: France name: Christian Roux role: CONTACT phone: 0492039220 email: roux.c2@chu-nice.fr name: Isa Costantini role: CONTACT phone: 0492039220 email: constantini.i@chu-nice.fr name: Christian Roux role: PRINCIPAL_INVESTIGATOR name: Antonio Iannelli role: SUB_INVESTIGATOR lat: 43.70313 lon: 7.26608 hasResults: False
nctId: NCT06314178 id: p-2024-15469 briefTitle: Assessing Demographic Biases in Deep Learning Model for Fetal Growth Estimation in Clinical Practice. Patients Eligible for Inclusion Are Women With a Gestational Age Between 24-42 Weeks Undergoing a Third-trimester Growth Scan. The Image Data From the Scan Are Used to Calculate Fetal Weight. overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-07-30 date: 2024-07-30 date: 2024-03-15 date: 2024-03-15 name: Copenhagen Academy for Medical Education and Simulation class: OTHER briefSummary: The goal of this observational study is to compare a new artificial intelligence (AI) feedback tool with the traditional method for estimating fetal weight during ultrasound scans on pregnant women between 24-42 weeks of gestation. The study aims to investigate the presence of demographic bias in the AI model. The demographic factors examined in the study include Body Mass Index (BMI), the number of births, fetal age, mother\'s age, fetal sex, and the presence of preeclampsia. Moreover, the study will compare the accuracy of the AI model and the Hadlock model, a fetal growth formula, in estimating fetal weight. Participants will have their ultrasound scans pseudonymized and securely stored on password-protected removable drives, ensuring their identity and privacy are maintained. Afterward, the ultrasound data will be sent to the Technical University of Denmark (DTU), where the AI model will analyze the images to estimate fetal weight. conditions: Pregnancy Complications studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 300 type: ESTIMATED measure: Demographic biases measure: Comparing the accuracy of the Hadlock formula and the AI model sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06314165 id: PamukkaleU-SBE-RND-01 briefTitle: Evaluation of the Effect of Music Medicine Application on Menstrual Symptoms overallStatus: RECRUITING date: 2024-03-10 date: 2025-02 date: 2025-02 date: 2024-03-15 date: 2024-03-21 name: Pamukkale University class: OTHER briefSummary: In this study, the "Music Medicine Application" method was chosen in line with the literature and guidelines and it is aimed to determine whether it is effective in reducing the symptoms experienced by female students with "Music Medicine Application" during the menstrual period. conditions: Menstruation; Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two groups: comparative experiment and control primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: Participants included in the study will not know which group they are in. In this way, the study will be carried out in a single-blind manner. whoMasked: PARTICIPANT count: 62 type: ESTIMATED name: music medicine practice measure: menstruation symptom scale measure: Visual Analogue Scale sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Pamukkale University Faculty of Health Sciences status: RECRUITING city: Denizli zip: 20180 country: Turkey name: Rabia Nur Doğan role: CONTACT phone: +905528400797 email: rabianur_1997@hotmail.com lat: 37.77417 lon: 29.0875 hasResults: False