* Patients in Group B will be debrided as well and the infected bone will be debrided without eliminating completely the structure of the bone, but instead preserving the cortex, while all the soft bone visibly infected will be removed and then replaced with Bioactive glass, as per IFU, (S53P4 - Bonalive® granules and putty, Bonalive Biomaterials Ltd. Finland) and then closed for primary intention whenever possible. conditions: Osteomyelitis - Foot studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 140 type: ESTIMATED name: Bioactive Glass name: Standard of Care measure: healing rate measure: Duration of antibiotic therapy measure: Rate of recurrences measure: Number of re-interventions because of the same lesion measure: Timing of re-interventions because of the same lesion measure: Proportion of patients undergoing amputations measure: Patients' Quality of Life measure: Patients' Quality of Life measure: Time back to walk measure: Characteristics of surgery measure: Length of surgery sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ASUGI Azienda Sanitaria Universitaria Giuliano Isontina - Ospedale Monfalcone status: NOT_YET_RECRUITING city: Monfalcone state: Gorizia zip: 34074 country: Italy name: Dr. Roberto Da Ros, Med Doctor role: CONTACT phone: +39 3470606008 email: roberto.daros@aas2.sanita.fvg.it name: Dr. Roberto Da Ros, Med Doctor role: PRINCIPAL_INVESTIGATOR lat: 45.80463 lon: 13.53292 facility: ASST Ovest Milanese - Ospedale di Abbiategrasso status: RECRUITING city: Abbiategrasso state: Milano zip: 20081 country: Italy name: Dr. Roberto De Giglio, Med Doctor role: CONTACT phone: +39 331 6989775 email: roberto.degiglio@asst-ovestmi.it name: Dr. Roberto De Giglio, Med Doctor role: PRINCIPAL_INVESTIGATOR name: Dr. Ilaria Formenti, Med Doctor role: SUB_INVESTIGATOR name: Dr. Vincenzo Curci, Med Doctor role: SUB_INVESTIGATOR lat: 45.39821 lon: 8.91678 facility: Casa di Cura Abano Terme - POLICLINICO ABANO TERME status: NOT_YET_RECRUITING city: Abano Terme state: Padova zip: 35031 country: Italy name: Dr. Christine Whisstock, Med Doctor role: CONTACT phone: +39 338 8924624 email: cwhisstock@casacura.it name: Dr. Christine Whisstock, Med Doctor role: PRINCIPAL_INVESTIGATOR lat: 45.35753 lon: 11.78725 facility: USL Sud Est Toscana - Ospedale San Donato status: NOT_YET_RECRUITING city: Arezzo zip: 52100 country: Italy name: Dr. Alessia Scatena, Med Doctor role: CONTACT phone: +39 328 3281501 email: alessia.scatena@uslsudest.toscana.it name: Dr. Alessia Scatena, Med Doctor role: PRINCIPAL_INVESTIGATOR name: Dr. Matteo Apicella, Med Doctor role: SUB_INVESTIGATOR lat: 43.46276 lon: 11.88068 facility: AUSL Romagna - Ospedale Morgagni Pierantoni status: NOT_YET_RECRUITING city: Forlì zip: 47121 country: Italy name: Dr. Silvia Acquati, Med Doctor role: CONTACT phone: +39 335 1239344 email: silvia.acquati@auslromagna.it name: Dr. Silvia Acquati, Med Doctor role: PRINCIPAL_INVESTIGATOR lat: 44.22177 lon: 12.04144 facility: Azienda USL Toscana Nord Ovest - Ospedale Campo di Marte status: NOT_YET_RECRUITING city: Lucca zip: 55100 country: Italy name: Dr. Ilaria Casadidio, Med. Doctor role: CONTACT phone: +39 3284882078 email: ilaria.casadidio@uslnordovest.toscana.it name: Dr. Ilaria Casadidio, Med Doctor role: PRINCIPAL_INVESTIGATOR lat: 43.84369 lon: 10.50447 facility: AOU Pisana - Ospedale di Cisanello status: NOT_YET_RECRUITING city: Pisa zip: 5612 country: Italy name: Prof. Alberto Piaggesi, Med Doctor role: CONTACT phone: +39 3473331949 email: alberto.piaggesi@med.unipi.it name: Dr. Chiara Goretti, Med Doctor role: CONTACT phone: +39 3294125791 email: chiara.goretti@gmail.com name: Prof. Alberto Piaggesi, Med Doctor role: PRINCIPAL_INVESTIGATOR name: Dr. Chiara Goretti, Med Doctor role: SUB_INVESTIGATOR lat: 43.70853 lon: 10.4036 hasResults: False