The intervention duration for all the study participants is 12 weeks (intervention phase). Subsequently, the participants will be invited to return to site for an end of study assessment after 21 days of no intervention (post-intervention phase). conditions: Diarrhea-Predominant Irritable Bowel Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized, Double-blind, Placebo-controlled primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 380 type: ESTIMATED name: Pasteurized Akkermansia muciniphila (pAKK) name: Placebo measure: To assess the impact of Investigational Product relative to placebo on percentage responders in terms of improvement of the IBS-Symptom Severity Scores (SSS) in participants with moderate to severe diarrhea-predominant irritable bowel syndrome. measure: To assess the impact of the Investigational Product in comparison to placebo on the percentage of participants who are responders in terms of improvement of the IBS-SSS from baseline at week 8 measure: To assess the impact of the Investigational Product in comparison to placebo on mean change in Generalized Anxiety Disorder (GAD)-7 score measure: To assess the impact of the Investigational Product in comparison to placebo on the percentage of participants who are responders in terms of improvement of the GAD-7 from baseline at week 12. measure: To assess the impact of the Investigational Product in comparison to placebo on mean change in Patient Health Questionnaire (PHQ)-9 score measure: To assess the impact of the Investigational Product in comparison to placebo on the percentage of participants who are responders in terms of improvement of the PHQ-9 from baseline at week 12. measure: To assess the impact of the Investigational Product in comparison to placebo on mean change in Perceived Stress Scale (PSS) measure: To assess the impact of the Investigational Product in comparison to placebo on mean change in Bristol Stool Form Score (BSFS) measure: To assess the impact of the Investigational Product in comparison to placebo on occurrence of normal BSFS score at the end of the study measure: To assess the impact of the Investigational Product in comparison to placebo on the quality of life as assessed by the mean change in IBS-QOL scores measure: To assess the impact of the Investigational Product in comparison to placebo on mean change in IBS-SSS value measure: To assess the impact of the Investigational Product in comparison to placebo on compliance with the intake of the investigational product measure: To assess the impact of the Investigational Product in comparison to placebo on Safety and tolerance measure: To assess the impact of the Investigational Product in comparison to placebo on the impact of IBS on their quality of life using the IBS-Quality of Life (IBS-QoL) instrument. sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: HCG Hospital city: Ahmedabad state: Gujarat zip: 380006 country: India name: Dr. Manoj Vithalani, MBBS, MD role: CONTACT phone: 9825024355 email: drmvithalani@gmail.com name: Dr. Manoj Vithalani, MBBS, MD role: PRINCIPAL_INVESTIGATOR lat: 23.02579 lon: 72.58727 facility: Anand Multispeciality Hospital city: Vadodara state: Gujarat zip: 390016 country: India name: Dr. Himanshu Patel, MBBS, DNB role: CONTACT phone: 8141001672 email: dr.himanshuvpatel@gmail.com name: Dr. Himanshu Patel, MBBS, DNB role: PRINCIPAL_INVESTIGATOR lat: 22.29941 lon: 73.20812 facility: Stress Test Clinic city: Mumbai state: Maharashtra zip: 400059 country: India name: Dr. Ramesh Dargad, MBBS, MD role: CONTACT phone: 9820152828 email: rohitdargad@outlook.com name: Dr. Ramesh Dargad, MBBS, MD role: PRINCIPAL_INVESTIGATOR lat: 19.07283 lon: 72.88261 facility: Criticare Asia Multispeciality Hospital & Research Centre city: Mumbai state: Maharashtra zip: 400069 country: India name: Dr. Sanjeev Khanna, MD, MNAMS role: CONTACT phone: 9820055090 email: dr.sanjeevkhanna@yahoo.com name: Dr. Sanjeev Khanna, MD, MNAMS role: PRINCIPAL_INVESTIGATOR lat: 19.07283 lon: 72.88261 facility: Surya Multispeciality Hospital city: Nashik state: Maharashtra zip: 422003 country: India name: Dr. Gaurav Bachhav, MD, DM role: CONTACT phone: 9867111119 email: drgauravbachhav@gmail.com name: Dr. Gaurav Bachhav, MD, DM role: PRINCIPAL_INVESTIGATOR lat: 19.99727 lon: 73.79096 facility: Astha Clinic city: Nashik state: Maharashtra zip: 422011 country: India name: Dr. Mohit Chaudhary, MBBS, MD role: CONTACT phone: 7744825746 email: m.chaudhary8@gmail.com name: Dr. Mohit Chaudhary, MBBS, MD role: PRINCIPAL_INVESTIGATOR lat: 19.99727 lon: 73.79096 facility: Apollo Hospital city: Navi Mumbai state: Maharashtra zip: 400614 country: India name: Dr. Amey Sonavane, MBBS, DNB role: CONTACT phone: 9619879955 email: amey_max@yahoo.com name: Dr. Amey Sonavane, MBBS, DNB role: PRINCIPAL_INVESTIGATOR lat: 19.03681 lon: 73.01582 facility: Swara Hospital city: Palghar state: Maharashtra zip: 401303 country: India name: Dr. Prashant Walke, MBBS, MD role: CONTACT phone: 9860844434 email: walkedrprashant@gmail.com name: Dr. Prashant Walke, MBBS, MD role: PRINCIPAL_INVESTIGATOR lat: 19.69693 lon: 72.76543 facility: Gastrohub Hospital city: Pune state: Maharashtra zip: 411027 country: India name: Dr. Mandar Doiphode, MBBS, DNB role: CONTACT phone: 9850077168 email: mandardoiphode22@gmail.com name: Dr. Mandar Doiphode, MBBS, DNB role: PRINCIPAL_INVESTIGATOR lat: 18.51957 lon: 73.85535 facility: Umarji Mother and Child Care Hospital city: Pune state: Maharashtra zip: 411045 country: India name: Dr. Prasad Bhatte, MD DM role: CONTACT phone: 9920039265 email: prasadbhate07@gmail.com name: Dr. Prasad Bhatte, MD DM role: PRINCIPAL_INVESTIGATOR lat: 18.51957 lon: 73.85535 facility: Lifeline Multispeciality Hospita city: Pune state: Maharashtra zip: 412101 country: India name: Dr. Shrikant Kote, MBBS, MD role: CONTACT phone: 7506360679 email: shri.kote86@gmail.com name: Dr. Shrikant Kote, MBBS, MD role: PRINCIPAL_INVESTIGATOR lat: 18.51957 lon: 73.85535 facility: Asian Institute of Medical sciences city: Thāne state: Maharashtra zip: 421203 country: India name: Dr Vineet Chaudhari, MD, DNB role: CONTACT phone: 7337422597 email: chaudhari.vineet@gmail.com name: Dr Vineet Chaudhari role: PRINCIPAL_INVESTIGATOR lat: 19.19704 lon: 72.96355 facility: Maharaja Agrasen Superspeciality Hospital city: Jaipur state: Rajasthan zip: 302039 country: India name: Dr. Prabhat K Sharma, MBBS, MD role: CONTACT phone: 9983995050 email: pksharma.clinical@gmail.com name: Dr. Prabhat K Sharma, MBBS, MD role: PRINCIPAL_INVESTIGATOR lat: 26.91962 lon: 75.78781 facility: Samvedna Hospita city: Varanasi state: Uttar Pradesh zip: 221005 country: India name: Dr. Hemant K Gupta, MBBS, MD, DM role: CONTACT phone: 8573888800 email: drhemantg26@gmail.com name: Dr. Hemant K Gupta, MBBS, MD, DM role: PRINCIPAL_INVESTIGATOR lat: 25.31668 lon: 83.01041 hasResults: False