hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06370663 id: SDZLEC2023-109-01 briefTitle: First-line Treatment for Unresectable Locally Advanced Distal Cholangiocarcinoma Combining Radiotherapy and HAIC overallStatus: RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-04-01 date: 2024-04-17 date: 2024-04-17 name: Shandong Cancer Hospital and Institute class: OTHER briefSummary: The median survival of intrahepatic cholangiocarcinoma remains less than one year, highlighting the need for new treatments. Hepatic arterial infusion chemotherapy (HAIC), especially with fluoropyrimidine-based regimens, has shown promise in ICC treatment due to increased local drug concentration and reduced systemic toxicity. A combined approach of radiotherapy and HAIC with gemcitabine infusion may offer a hopeful strategy for locally advanced cholangiocarcinoma. However, clinical research on this combination is lacking as first-line therapy for unresectable ICC. Therefore, a single-center, single-arm study aims to assess this treatment approach's safety, efficacy, and molecular predictors. Improved HAIC delivery through modified percutaneous implantation provides a reliable pathway for effective treatment. In conclusion, exploring the synergistic effects of radiotherapy and HAIC in ICC could pave the way for more effective and personalized treatment strategies for this challenging cancer type. conditions: Intrahepatic Cholangiocarcinoma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Combining radiotherapy with Hepatic Arterial Infusion Chemotherapy primaryPurpose: TREATMENT masking: NONE count: 32 type: ESTIMATED name: Radiotherapy name: HAIC (GEMOX) name: Chemotherapy measure: Adverse Events measure: Progression-Free Survival (PFS) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Jinbo Yue status: RECRUITING city: Jinan state: Shandong zip: 250000 country: China name: Jin Bo Yue, Doctor role: CONTACT phone: 0531-67626929 email: Len.Xu@hotmail.com lat: 36.66833 lon: 116.99722 hasResults: False
nctId: NCT06370650 id: soh-med-24-1-9 briefTitle: Effect of Platelet Rich Plasma on Outcome of Narrow Band UVB in Treatment of Vitiligo; Clinical and Histopathological Study overallStatus: ACTIVE_NOT_RECRUITING date: 2023-12-08 date: 2024-01-25 date: 2024-06-30 date: 2024-04-17 date: 2024-04-17 name: Sohag University class: OTHER briefSummary: For each patient, one side of body will be treated with NB-UVB alone while the other side will be treated with NB-UVB therapy in addition to intradermal injection of PRP every 2 weeks. Patients will be photographed at the first visit, in the middle and at the end of therapy. Each patient will sign a written consent form to be included in the study and to be photographed. conditions: Management of Stable Vitiligo studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ACTUAL name: platelet rich plasma, narrow band UVB measure: Improvement of vitiligo sex: ALL minimumAge: 15 Years maximumAge: 50 Years stdAges: CHILD stdAges: ADULT facility: Faculty of Medicine, Sohag University city: Sohag zip: 82515 country: Egypt lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06370637 id: Survey Protocol briefTitle: Efficacy of Cream for Moisture Associated Skin Damage From Fecal Incontinence and/or Diarrhea acronym: Survey overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2026-05 date: 2024-04-17 date: 2024-04-17 name: Scotiaderm class: OTHER briefSummary: Scotiaderm Inc. has developed a cream formulation to be used in the treatment of MASD caused diarrhea or fecal incontinence. This study aims to evaluate the efficacy and safety of a plant extract incorporated into a standard barrier in the treatment of MASD from diarrhea and/or fecal incontinence. The goal of this research is to conduct an open-label outpatient study of this novel cream in a population with MASD secondary to diarrhea and/or fecal incontinence. conditions: Incontinence-associated Dermatitis conditions: Moisture Associated Skin Damage (MASD) (E.G., Incontinence-Associated Dermatitis [IAD], Perspiration, Drainage) conditions: Fecal Incontinence Incontinence-associated Dermatitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescription: The aim of this study is to evaluate the efficacy and safety of a plant extract incorporated into a standard barrier in the treatment of MASD from diarrhea and/or fecal incontinence. The goal of this research is to conduct an open-label outpatient study of this novel cream in a population with MASD secondary to diarrhea and/or fecal incontinence. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: A total of 40 patients will be enrolled in the study. If the patient agrees to participate and written consent is given to participate, the research coordinator will assess the eligibility criteria of the patient based on the inclusion and exclusion criteria. Participants will be provided 2x2cm patch test on the forearm to test for contact dermatitis to the cream D after obtaining consent. Participants do not react to the Cream D will be randomized. Participants who react will be excluded from the study. The research coordinator will have a list for arm 1 and arm 2 where the code for the participant enrolled will be entered daily. The first participants to be enrolled on any given day will be assigned to arm 1, and the second patient to arm 2. The research coordinator will have 40 envelopes with the protocols coded with arm 1 or arm 2, and cream containers also coded with arm 1 and arm 2. whoMasked: PARTICIPANT count: 40 type: ESTIMATED name: MASD Control Arm measure: Analysis of Efficacy and Safety for Cream D Primary Outcome measure: Analysis of Efficacy and Safety for Cream D Secondary Outcome sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06370624 id: 2022/03OCT/360 briefTitle: PEDI-REAVASC Resonance Imaging of Infants With Hypoxic Ischemic Encephalopathy After Hypothermia Treatment. acronym: PEDI-REAVASC overallStatus: ACTIVE_NOT_RECRUITING date: 2023-01-17 date: 2025-09-15 date: 2025-10-01 date: 2024-04-17 date: 2024-04-17 name: Cliniques universitaires Saint-Luc- Université Catholique de Louvain class: OTHER briefSummary: This study is a prospective, observational, single-center study to assess the correlation between rs-fMRI measures and clinical measures of standard MRI, NIRS, EEG and clinical scores.
A one-year clinical and imaging follow-up is planned. As the aim of the present study is to assess the predictiveness of the outcome one year after the HIE event, no follow-up is planned. conditions: Encephalopathy, Hypoxic-Ischemic studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: One group will be followed - with both the standard of care continuous EEG monitoring and near infrared spectroscopy (NIRS) \& the MRI-scan performed at the same time. primaryPurpose: DIAGNOSTIC masking: NONE count: 30 type: ESTIMATED name: MRI-scan measure: quantifying cerebrovascular reactivity (CVR) by resting-state functional MRI (r-fMRI) in infants with moderate to severe hypoxic-ischaemic encephalopathy (HIE) sex: ALL minimumAge: 1 Hour maximumAge: 14 Months stdAges: CHILD facility: Cliniques Universitaires Saint Luc city: Brussels zip: 1200 country: Belgium lat: 50.85045 lon: 4.34878 hasResults: False
nctId: NCT06370611 id: 2314027 briefTitle: Early Remote Rehabilitation to Improve Health of the Elderly After Cardiac Surgery. (RECARD Trial) acronym: RECARD overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-09-30 date: 2026-09-30 date: 2024-04-17 date: 2024-04-17 name: Ivy susanne Modrau, MD class: OTHER name: Aalborg University Hospital briefSummary: An increasing number of older patients undergo heart surgery. Despite seemingly successful outcomes, these vulnerable patients may face prolonged decreased functional capacity, reduced self-efficacy, and impaired quality of life after discharge. Early engagement in physical activity and education plays a key role in health and well-being after heart surgery The goal of this clinical trial is to evaluate the effectiveness of an app-based exercise program and weekly calls from a physiotherapist in the early stages after open heart surgery.
The primary endpoint is the 30-second Chair Stand Test serving as a measurement of physical function. conditions: Cardiac Rehabilitation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Bi-center, prospective, randomized, controlled, parallel (1:1), two-arm, open-label, blinded evaluation (PROBE) trial primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Allocation cannot be concealed from the participants, care providers or investigator. Outcome assessors will be blinded regarding allocation. whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: Early mobile health intervention supplemented by weekly calls from a physiotherapist measure: Change (Δ) 30-second chair stand test (30CST) baseline vs. 6-week FU measure: Change (Δ) in 10-meter Walk Test (10MWT) baseline vs. 6-week FU measure: Difference in 6-minute Walk Test (6MWT) between groups at 6-week FU measure: Change (Δ) in WHO-5-score baseline vs. 6-week FU measure: Change (Δ) in ASS-2-score baseline vs. 6-week FU measure: Change (Δ) in MDI-2-score baseline vs. 6-week FU measure: Change (Δ) in Self-reported Physical Activity baseline vs. 6-week FU measure: Change (Δ) in EuroQol-score baseline vs. 6-week FU measure: Change in skeletal muscle mass maximum 3 months prior to surgery vs. 6-week FU measure: Cost-effectiveness analysis measure: Changes in markers of musculoskeletal health through blood samples baseline vs. 6-week FU measure: Changes in markers of inflammation through blood samples baseline vs. 6-week FU measure: Changes in markers of nutrition through blood samples baseline vs. 6-week FU measure: Changes in markers of liver function through blood samples baseline vs. 6-week FU measure: Changes in markers of kidney function through blood samples baseline vs. 6-week FU measure: Changes in markers of hormone levels through blood samples baseline vs. 6-week FU sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Aarlborg University Hospital city: Aalborg zip: 9000 country: Denmark name: Stian Ingemann-Molden, PT, MHSc role: CONTACT phone: +45 97664210 email: s.ingemannmolden@rn.dk lat: 57.048 lon: 9.9187 facility: Aarhus University Hospital city: Aarhus zip: 8200 country: Denmark name: Rikke Daugaard, PT, MHSc role: CONTACT phone: +45 41282266 email: daugaard@clin.au.dk lat: 56.15674 lon: 10.21076 hasResults: False
nctId: NCT06370598 id: TP-122 briefTitle: Phase 1/2a to Assess the Safety and Tolerability of TP-122A for the Treatment of Ventilator-Associated Pneumonia acronym: RECOVER overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2025-05 date: 2025-06 date: 2024-04-17 date: 2024-04-17 name: Technophage, SA class: INDUSTRY name: VectorB2B briefSummary: Given the challenges of treating complex cases of VAP caused by P. aeruginosa and K. pneumoniae, TechnoPhage developed a bacteriophage cocktail (TP-122) against those pathogens, aiming to provide a hospital-based add-on therapy to the SoC including antibiotic therapy, administered by nebulization. TP-122 is a bacteriophage cocktail divided in two different components: TP-122A is comprised of three bacteriophages against infections caused by Pseudomonas aeruginosa and TP-122B includes three bacteriophages against K. pneumoniae . For this study, an effective sample of 15 subjects will be randomly allocated into two arms, in a 3:2 ratio, with 9 subjects receiving TP-122A, in addition to SoC, and 6 subjects receiving the SoC alone. conditions: Pneumonia, Ventilator-Associated studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 15 type: ESTIMATED name: TP-122A measure: Evaluate safety and tolerability following nebulization of multiple doses of TP-122A measure: Proportion of subjects achieving "Clinical Cure" CR measure: Time to achieve "Clinical Cure" CR measure: Proportion of subjects achieving "Eradication" or "Presumed Eradication" MR of TP-122A target bacteria measure: Time to achieve "Eradication" or "Presumed Eradication" MR sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CH Nantes city: Nantes country: France name: Antoine Roquilly, MD role: CONTACT name: Antoine Roquilly, MD role: PRINCIPAL_INVESTIGATOR lat: 47.21725 lon: -1.55336 hasResults: False
nctId: NCT06370585 id: SOPH229-0823/I briefTitle: Clinical Study to Evaluate the Safety and Tolerability of PRO-229 Ophthalmic Solution Compared to Lagricel® Ofteno PF overallStatus: NOT_YET_RECRUITING date: 2024-05-30 date: 2024-09-30 date: 2024-09-30 date: 2024-04-17 date: 2024-04-17 name: Laboratorios Sophia S.A de C.V. class: INDUSTRY briefSummary: This is a phase I study evaluating safety and tolerability of PRO-229 ophthalmic solution through he incidence of unexpected adverse events, changes in Best Corrected Visual Acuity (BCVA), incidence of chemosis, and changes in ocular surface staining using the Sjögren's International Collaborative Clinical Alliance (SICCA) Ocular Staining Score (OSS) scale compared to Lagricel® Ofteno PF in clinically healthy subjects. conditions: Dry Eye Disease conditions: Ocular Surface Disease studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Phase I, controlled, comparative, double-masked, single-center, randomized, controlled clinical trial. primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 36 type: ESTIMATED name: PRO-229 name: Lagricel® Ofteno PF measure: Incidence Unexpected Related Adverse Reactions measure: Changes in Best Corrected Visual Acuity (BCVA) measure: Changes in ocular surface staining using SICCA ocular staining score scale measure: Incidence of chemosis measure: Incidence of grade 3 or 4 conjunctival hyperemia. measure: Adherence to treatment (adherence) sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT hasResults: False
nctId: NCT06370572 id: CIRB23-1162 id: U54AG063546 type: NIH link: https://reporter.nih.gov/quickSearch/U54AG063546 briefTitle: Pragmatic Use of PAIN-Advanced Dementia Scale in Emergency Departments overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-05 date: 2025-05 date: 2024-04-17 date: 2024-04-19 name: University of Chicago class: OTHER name: National Institute on Aging (NIA) name: University of North Carolina, Chapel Hill briefSummary: The purpose of this study is to learn if the Pain in Advanced Dementia (PAINAD) scale can improve emergency pain care in persons living with dementia (PLWD). It is hypothesized that a PAINAD electronic health record (EHR) prompt that appears to emergency department (ED) staff will enable them to accurately assess pain levels and lead to better pain treatment for PLWD. conditions: Dementia conditions: Hip Pain conditions: Emergency Department Patient conditions: Pain in Advanced Dementia Scale studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: This is a interrupted time series intervention, which allows a pre- and post-intervention assessment of the effect of PAINAD scale. primaryPurpose: TREATMENT masking: NONE count: 1899 type: ESTIMATED name: PAINAD EHR Prompt measure: Percentage of eligible patients receiving a PAINAD assessment upon ED arrival measure: Change in time to administration of first analgesic medication measure: Change in pain score for patients receiving a repeat PAINAD assessment sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: University of Chicago city: Chicago state: Illinois zip: 60637 country: United States name: Teresita M Hogan, MD role: CONTACT phone: 773-702-9500 name: Teresita M Hogan, MD role: PRINCIPAL_INVESTIGATOR lat: 41.85003 lon: -87.65005 facility: University of North Carolina at Chapel Hill city: Chapel Hill state: North Carolina zip: 27599 country: United States name: Michelle Meyer, PhD, MPH, CPH role: CONTACT phone: (919) 966-6442 name: Michelle Meyer, PhD, MPH, CPH role: PRINCIPAL_INVESTIGATOR lat: 35.9132 lon: -79.05584 hasResults: False
nctId: NCT06370559 id: 339042 briefTitle: Relationship Between Repetitive Negative Thinking and CBT Outcomes overallStatus: COMPLETED date: 2022-01-01 date: 2024-02-01 date: 2024-02-01 date: 2024-04-17 date: 2024-04-17 name: South London and Maudsley NHS Foundation Trust class: OTHER briefSummary: The goal of this observational study is to learn about the role of repetitive negative thinking (measured by the RTQ) in adult populations from an anxiety disorders and trauma clinic.
Researchers may also compare clients with different disorders to see the accuracy the RTQ can predict treatment outcomes for each disorder. conditions: Anxiety Disorders conditions: Obsessive-Compulsive Disorder conditions: Post-traumatic Stress Disorder conditions: Social Anxiety Disorder conditions: Specific Phobia conditions: Panic Disorder conditions: Body Dysmorphic Disorders studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 320 type: ACTUAL measure: Change in Repetitive Ruminative Thinking Questionnaire score measure: Change in disorder-specific measure score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre for Anxiety Disorders and Trauma city: London zip: SE5 8AZ country: United Kingdom lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06370546 id: 229/2022 briefTitle: Cardiac Response to Strength Training in Hypertensive Individuals overallStatus: RECRUITING date: 2023-03-20 date: 2024-07-20 date: 2024-07-20 date: 2024-04-17 date: 2024-04-25 name: Universidad Católica del Maule class: OTHER briefSummary: This study aims to determine the acute and chronic effects of high and low-intensity strength training on cardiac autonomic control in hypertensive subjects conditions: Physical Exercise conditions: Hypertension studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized clinical trial, single blinded. primaryPurpose: TREATMENT masking: NONE count: 28 type: ESTIMATED name: Low intensity name: high intensity measure: Heart rate variability measure: Blood pressure systolic measure: Blood pressure diastolic measure: Blood pressure mean measure: Heart Rate sex: ALL minimumAge: 30 Years maximumAge: 60 Years stdAges: ADULT facility: Universidad Católica del Maule status: RECRUITING city: Talca state: Maule zip: 3469001 country: Chile name: Luis Benavides Roca, PhD(c) role: CONTACT phone: +5699926 8137 email: benavides.roca@gmail.com name: Luis Benavides Roca, PhD(c) role: PRINCIPAL_INVESTIGATOR lat: -35.4264 lon: -71.65542 hasResults: False
nctId: NCT06370520 id: 123 briefTitle: Screening Emotions in Adolescents at the Hospital for mTBI acronym: SEARCH-mTBI overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2028-09 date: 2028-12 date: 2024-04-17 date: 2024-04-23 name: University of California, Davis class: OTHER name: Pediatric Emergency Care Applied Research Network briefSummary: The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing significant new or worsening mental health conditions.
nctId: NCT06370507 id: UPO2# briefTitle: Monitoring of Lung Ventilation Through Electrical Impedance Tomography During Pediatric Surgery acronym: VentiPed overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-12-31 date: 2025-07-31 date: 2024-04-17 date: 2024-04-17 name: Azienda Ospedaliero Universitaria Maggiore della Carita class: OTHER briefSummary: Given the scarcity of studies aimed at assessing the effect of anesthesia and m ventilation on the distribution of lung ventilation in pediatric patients undergoing surgery, with the exclusion of thoracic surgery, the present prospective observational study would shed the light on ventilation practice in pediatric anesthesia for surgery. This study wold fill the actual gap allowing the evaluation, through electrical impedance tomography (EIT) of the distribution of lung ventilation across the different phases of anesthesia for pediatric surgery. These insights could contribute to improve clinical practice and research in the management of ventilation in pediatric patients undergoing anesthesia for surgery. conditions: Ventilator Lung conditions: Surgery conditions: Pediatric studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: PROSPECTIVE count: 800 type: ESTIMATED name: Electrical impedance tomography assessment of ventilation distribution in course of sedation/general anesthesia for pediatric surgery measure: Ventilation distribution measure: Intraoperative ventilatory respiratory mechanics measure: Postoperative pulmonary complications measure: Intraoperative oxygenation measure: Intraoperative hemodynamics sex: ALL minimumAge: 0 Days maximumAge: 14 Years stdAges: CHILD hasResults: False
nctId: NCT06370494 id: IRB2020-0956D briefTitle: Testing New Models of Diabetes Self-Management to Improve Population Health overallStatus: COMPLETED date: 2019-02-01 date: 2022-03-31 date: 2022-03-31 date: 2024-04-17 date: 2024-04-17 name: Texas A&M University class: OTHER name: Blue Cross Blue Shield briefSummary: Aim 1.1 To understand if diabetes self-management education and support (DSMES) improves diabetes-related outcomes among those with Type 2 diabetes living in Texas.
These aims are based on a randomized controlled trial of different evidence-based diabetes self-management interventions. conditions: Diabetes Mellitus, Type 2 studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: A randomized controlled trial (RCT) was conducted to assess the outcomes associated with different technological intervention approaches. This 3-arm RCT assessed independent and combined interventions: primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 191 type: ACTUAL name: Living Healthier with Diabetes measure: A1C -Change in HbA1c between baseline, 3 months, and 6 months is the primary outcome. measure: Diabetes Knowledge: Knowledge of diabetes will be measured by the simplified version of the Revised Diabetes Knowledge Scale (True/False version). measure: Diabetes Self Care measure: Diabetes Care Confidence measure: Diabetes care distress measure: A1C sex: ALL minimumAge: 25 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Texas A&M Health city: College Station state: Texas zip: 77843-1266 country: United States lat: 30.62798 lon: -96.33441 hasResults: False