hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06389331 id: IRC/1971/020 briefTitle: Study on Effects of Defect Closure in Laparoscopic Repair of Direct Inguinal Hernia overallStatus: COMPLETED date: 2020-09-01 date: 2021-06-30 date: 2021-08-31 date: 2024-04-29 date: 2024-04-29 name: B.P. Koirala Institute of Health Sciences class: OTHER briefSummary: The defect closure was found to have higher pain and less seroma formation at various intervals of time following TEP for moderate-large direct inguinal hernia. Although these findings were statistically insignificant, they may be clinically significant, and further studies with a larger sample size are suggested. conditions: Hernia conditions: Direct Inguinal Hernia conditions: Seroma Following Procedure studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 88 type: ACTUAL name: closed the defect with barbed suture measure: seroma sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Vijay Pratap Sah city: Malangwa state: Madhesh Pradesh country: Nepal lat: 26.85679 lon: 85.55811 typeAbbrev: Prot_ICF hasProtocol: True hasSap: False hasIcf: True label: Study Protocol and Informed Consent Form date: 2020-09-01 uploadDate: 2024-04-24T12:06 filename: Prot_ICF_000.pdf size: 190465 hasResults: False
nctId: NCT06389318 id: RC 29-11-2023 briefTitle: Buccal Midazolam Versus Intranasal Dexmedetomidine Plus Oral Chloral Hydrate in Inguinal Hernia Repair overallStatus: COMPLETED date: 2023-03-26 date: 2024-03-26 date: 2024-04-24 date: 2024-04-29 date: 2024-04-29 name: Benha University class: OTHER briefSummary: Inguinal hernia surgery is one of the most common surgical procedures in early infancy. Preoperative anxiety remains a vexing issue, and it exists in nearly 50% of pediatric patients conditions: Inguinal Hernia Repair studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Group A (40 patients): Children received oral placebo syrup, Group B (40 patients): Children received oral chloral hydrate (Chloral Hydrate mixture) primaryPurpose: PREVENTION masking: DOUBLE maskingDescription: Both participant and the care-provider in this trial were blinded. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 80 type: ACTUAL name: buccal midazolam +oral placebo syrup name: oral chloral hydrate,intranasal dexmedetomidine and buccal normal saline measure: Ramsay sedation score measure: Parental separation anxiety scale sex: ALL minimumAge: 2 Years maximumAge: 7 Years stdAges: CHILD facility: Benha University city: Banha zip: 13511 country: Egypt lat: 30.45906 lon: 31.17858 hasResults: False
nctId: NCT06389305 id: BJGBYY-IIT-LCYJ-2024-012 briefTitle: CIK Cell Therapy for Relapsed or Refractory Acute B-Lymphoblastic Leukemia: Prognostic Impact on Patients With Early CAR-T Cell Dysfunction overallStatus: RECRUITING date: 2024-05-01 date: 2025-04-30 date: 2026-04-30 date: 2024-04-29 date: 2024-04-29 name: Beijing GoBroad Hospital class: OTHER briefSummary: This is a single-center, double-blind, randomized trial. Patients with r/r B-ALL experiencing early functional exhaustion of CAR-T cells will be randomly allocated into three groups: the control cell group, the CIK treatment group, and the mRNA-CIK treatment group. The primary objective of the study is to evaluate the prognostic impact of CIK cell therapy on the early functional exhaustion of CAR-T cells in children and adolescent and young adult (AYA) with r/r B-ALL. The primary endpoint of the study is the event-free survival rate of these patient in the CIK cell therapy group.A total number of 213 subjects will be enrolled. conditions: B-cell Acute Lymphoblastic Leukemia conditions: Acute Lymphoblastic Leukemia, in Relapse conditions: Refractory Acute Lymphoid Leukemia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: a prospective cohort study primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 213 type: ESTIMATED name: peripheral blood lymphocytes name: CIK cell measure: EFS in CIK infusion group measure: PFS in CIK infusion group measure: DOR in CIK infusion group measure: OS in CIK infusion group measure: EFS in mRNA-CIK infusion group sex: ALL minimumAge: 1 Year maximumAge: 39 Years stdAges: CHILD stdAges: ADULT facility: Beijing GoBroad Hospital status: RECRUITING city: Beijing state: Beijing zip: 102206 country: China name: Tengyu Wang role: CONTACT phone: 86+18333186020 email: tengyu.wang@gohealtharo.com lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06389292 id: APG2575AG301 briefTitle: A Pivotal Phase 3 Study of APG-2575 (Lisaftoclax) Combined With Azacytidine in the Treatment of Acute Myeloid Leukemia overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2028-05-25 date: 2029-03-26 date: 2024-04-29 date: 2024-04-29 name: Ascentage Pharma Group Inc. class: INDUSTRY briefSummary: An international multicenter, randomized, double-blind, placebo-controlled, phase III pivotal registration study, to evaluate the efficacy of APG-2575 (Lisaftoclax) combined with azacitidine (AZA) versus placebo combined with azacitidine in newly diagnosed acute myeloid leukemia who are not eligible for standard induction chemotherapy. conditions: Acute Myeloid Leukemia studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 486 type: ESTIMATED name: Lisaftoclax (APG-2575) name: Placebo name: Azacitidine Injection measure: Overall Survival（OS） measure: Percentage of Participants with Objective Response Rate (ORR) measure: Safety evaluation based on the adverse event concurrence sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hematology Hospital of the Chinese Academy of Medical Sciences city: Tianjin state: Tianjin zip: 300020 country: China name: Hui Wei, M.D. role: CONTACT phone: 022-23909120 email: weihui@ihcams.ac.cn name: Hui Wei, M.D. role: PRINCIPAL_INVESTIGATOR lat: 39.14222 lon: 117.17667 facility: The First Affiliated Hospital of Zhejiang University School of Medicine city: Hangzhou state: Zhejiang zip: 310003 country: China name: Jie Jin, M.D. role: CONTACT email: jiej0503@163.com role: CONTACT phone: 0571-87236896 name: Jie Jin, M.D. role: PRINCIPAL_INVESTIGATOR lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06389279 id: 2023-18/11 briefTitle: The Effect of Facial Plane Blocks on Postoperative Recovery Quality in Hip Surgery overallStatus: NOT_YET_RECRUITING date: 2024-04-24 date: 2024-09-24 date: 2024-10-24 date: 2024-04-29 date: 2024-04-29 name: Antalya Training and Research Hospital class: OTHER_GOV briefSummary: The aim of this study was to evaluate the effect of ultrasound-guided pericapsular nerve block, fascia iliaca compartment block, and femoral block on the quality of recovery as part of multimodal analgesia before hip surgery under spinal anesthesia. conditions: Hip Fracture studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 80 type: ESTIMATED name: PENG block group name: FIC block group name: Femoral block group name: Control group measure: recovery quality measure: postoperative Numeric Rating Scale (NRS) pain score measure: postoperative opioid consumption sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Health Sciences, Antalya Training and Researh Hospital city: Antalya country: Turkey name: Antalya Training and Research Hospital role: CONTACT lat: 36.90812 lon: 30.69556 hasResults: False
nctId: NCT06389266 id: 221550 briefTitle: Network-Targeted Neuromodulation for Nicotine Dependence in Schizophrenia overallStatus: RECRUITING date: 2023-06-15 date: 2029-01-10 date: 2029-01-10 date: 2024-04-29 date: 2024-04-29 name: Vanderbilt University Medical Center class: OTHER briefSummary: The goal of this clinical trial is to compare two active types of transcranial magnetic stimulation in two nicotine-using populations: nicotine-using people with psychosis and nicotine-using people without a diagnosis of a psychotic disorder. The main questions it aims to answer are:
Participants will complete tasks assessing their cognitive performance and craving before and after each week of TMS. Researchers will compare the effect of each TMS intervention on participants with and without psychosis to see if one type of TMS has an effect on nicotine craving. conditions: Schizophrenia conditions: Nicotine Dependence studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: All participants receive five days of DMN-targeted cTBS and five days of L DLPFC-targeted iTBS. The order in which participants receive the two types of TMS is randomized. primaryPurpose: BASIC_SCIENCE masking: NONE maskingDescription: The study is not sham-controlled, as both arms are active TMS treatments. The type of TMS is not masked from the participant or the investigator. Statistician will be blinded to intervention. count: 100 type: ESTIMATED name: Repetitive Transcranial Magnetic Stimulation (rTMS) measure: Resting-state functional connectivity measure: Cue-induced craving measure: Tiffany Brief Questionnaire of Smoking Urges (QSU) measure: Self-reported craving measure: Wisconsin Smoking Withdrawal Scale (WSWS) measure: Fagerstrom Test for Nicotine Dependence (FTND) measure: Self-reported nicotine use sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Vanderbilt University Medical Center status: RECRUITING city: Nashville state: Tennessee zip: 37232 country: United States name: Heather B Ward, MD role: CONTACT phone: 615-327-7000 email: heather.b.ward@vumc.org name: Sophia H Blyth, BA role: CONTACT phone: 6154345891 email: sophia.h.blyth@vumc.org name: Stephan Heckers, MD, MSc role: SUB_INVESTIGATOR name: Hilary A Tindle, MD, MPH role: SUB_INVESTIGATOR lat: 36.16589 lon: -86.78444 hasResults: False
nctId: NCT06389253 id: HTSW1 briefTitle: Subtalar Extra-articular Screw Arthroereisis overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-05 date: 2024-04-29 date: 2024-04-29 name: Università Vita-Salute San Raffaele class: OTHER briefSummary: The aim of the study is to investigate the effect of subtalar extra-articular calcaneo-stop screw on the proprioceptive and nociceptive pathways of the ankle before and after implantation. The hypothesis of the study is that an increased number of receptors related to proprioception will be detected in the sinus tarsi. conditions: Flatfoot, Flexible conditions: Ankle Proprioception studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 40 type: ESTIMATED name: Histological Analysis measure: Primary Endpoint (%) measure: Secondary Endpoint sex: ALL minimumAge: 10 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Ircss Ospedale San Raffaele city: Milan state: Lombardy zip: 20149 country: Italy lat: 45.46427 lon: 9.18951 facility: Università Vita-Salute San Raffaele city: Milan zip: 20132 country: Italy name: Francesco Pezone role: CONTACT role: CONTACT email: f.pezone@studenti.unisr.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06389240 id: 160848 briefTitle: Early Weight Bearing in Unicondylar Tibial Plateau Fractures overallStatus: ACTIVE_NOT_RECRUITING date: 2022-12-21 date: 2025-12 date: 2025-12 date: 2024-04-29 date: 2024-04-29 name: University of Utah class: OTHER briefSummary: The investigators aim of the study is to assess the effects of early mobilization after surgically treated unicondylar tibia plateau fractures (6 weeks without weight bearing) on gait, patient satisfaction, return to work/sports and complication rate. The data will be compared to a 10-12 week non-weight bearing group (standard of care).
It is assumed that earlier mobilization does not lead to an increase in the complications - in particular osteosynthesis failure and infections -, but leads to improved patient satisfaction, reduced return to work/sports times, and has a positive impact on the overall outcome conditions: Early Mobilization studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: 6 weeks post-operatively early weight bearing name: 10 weeks post-operatively weight bearing (standard of care) measure: Average peak load (Newtons (N)) measure: Average peak load (Newtons (N)) measure: Average peak load (Newtons (N)) measure: Average peak load (Newtons (N)) measure: Average peak load (Newtons (N)) measure: Average peak load (Newtons (N)) measure: Average peak load (Newtons (N)) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Utah Orthopedics city: Salt Lake City state: Utah zip: 84108 country: United States lat: 40.76078 lon: -111.89105 hasResults: False
nctId: NCT06389227 id: 0433611 briefTitle: Developing the Physical Performance in Youth Soccer: Short-term Effect of Dynamic-Ecological Versus Traditional Training Approach for Sub-élite U13 Players: An Ecological Exploratory Cluster Randomised Trial overallStatus: COMPLETED date: 2023-10-15 date: 2023-10-30 date: 2024-02-15 date: 2024-04-29 date: 2024-04-29 name: University of Turin, Italy class: OTHER briefSummary: Therefore, this study aims to verify the effects of a soccer training program based on the dynamic-ecological approach on U13 sub-elité players' physical efficiency by analysing explosive strength, speed, resistance to speed and muscle flexibility. This study hypothe-sises that the dynamic-ecological approach can consistently help players develop adequate physical efficiency and motor coordination. conditions: Verify the Effects of a Soccer Training Program Based on the Dynamic-ecological Approach on U13 Sub-elité Players' Physical Efficiency studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 35 type: ACTUAL name: dynamic ecological approach (DEA) name: traditional training group measure: Number of participants evaluated on physical efficiency sex: MALE minimumAge: 12 Years maximumAge: 13 Years stdAges: CHILD facility: Cit Turin LDE city: Turin zip: 10100 country: Italy lat: 45.07049 lon: 7.68682 hasResults: False
nctId: NCT06389214 id: ADX-102-DED-030 briefTitle: A Phase 3 Clinical Trial to Assess the Efficacy and Safety of Subjects With Dry Eye Disease overallStatus: RECRUITING date: 2024-04-09 date: 2024-12-31 date: 2024-12-31 date: 2024-04-29 date: 2024-04-29 name: Aldeyra Therapeutics, Inc. class: INDUSTRY briefSummary: A Randomized, Double-Masked, Vehicle-Controlled Parallel Group Clinical Trial to Assess Efficacy and Safety of 0.25% Reproxalap Ophthalmic Solution Compared to Vehicle in Subjects with Dry Eye Disease conditions: Dry Eye Disease studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 110 type: ESTIMATED name: Reproxalap Ophthalmic Solution (0.25%) name: Vehicle Ophthalmic Solution measure: Ocular discomfort symptom score over 100 minutes in the dry eye chamber at Visit 2 and Visit 4 sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cliantha Research status: RECRUITING city: Mississauga state: Ontario country: Canada name: Patricia Couroux, MD role: CONTACT phone: (888) 989-1808 email: pcouroux@cliantha.com lat: 43.5789 lon: -79.6583 hasResults: False
nctId: NCT06389201 id: 2024HCQ briefTitle: Pretreatment With HCQ Before Radiotherapy and Chemotherapy in Advanced NPC Patients overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-31 date: 2026-12-31 date: 2024-04-29 date: 2024-04-29 name: Affiliated Hospital of Nantong University class: OTHER briefSummary: Dormant cancer cells that survive anti-cancer therapy can lead to cancer recurrence and disseminated metastases that prove fatal in most cases. Recently, specific dormant polyploid giant cancer cells (PGCC) have drawn our attention because of their association with the clinical risk of nasopharyngeal carcinoma (NPC) recurrence, as demonstrated by previous clinical data. In study, we report the biological properties of PGCC, and reveal that autophagy is a critical mechanism of PGCC induction. Moreover, pharmacological inhibition of autophagy greatly impaired PGCC formation, significantly suppressing metastasis and improving survival in a mouse model. Mechanistically, chemotherapeutic drugs partly damaged mitochondria, and activated autophagy to promote PGCC formation. High numbers of PGCCs correlated with shorter recurrence time and worse survival outcomes in NPC patients. Collectively, these findings suggest a therapeutic approach of targeting dormant PGCCs in cancer.
Pretreatment with an autophagy inhibitor (HCQ) before chemotherapy and radiotherapy could prevent formation of therapy-induced dormant polyploid giant cancer cells, thereby reducing recurrence and metastasis of nasopharyngeal carcinoma. conditions: Nasopharyngeal Carcinoma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 30 type: ESTIMATED name: HCQ name: Placebo measure: Recurrence and metastasis sex: ALL minimumAge: 20 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bo You city: Nantong state: Jiangsu zip: 226000 country: China lat: 32.03028 lon: 120.87472 hasResults: False
nctId: NCT06389188 id: JVT003 briefTitle: Effectiveness of Cervical Osteopathic Manipulation in Patients With Whiplash overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-09-01 date: 2024-10-01 date: 2024-04-29 date: 2024-04-29 name: Universidad Miguel Hernandez de Elche class: OTHER name: Consorci Sanitari de Terrassa briefSummary: To determine the mid- and long-term efficiency (15, 30 and 120 days after starting sessions) of the SAT technique in patients with grade II acute WL, comparing it with a conventional rehabilitation program. conditions: Whiplash studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: RHB Group measure: Subjective pain intensity measure: Neck specific disability measure: Cervical range of motion (CROM) measure: Cervical lordosis Cobb angle measure: Hospital anxiety and depression scale sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Consorci Sanitari de Terrassa. city: Terrassa state: Barcelona zip: 08227 country: Spain name: Joan Parera-Turull, PhD role: CONTACT phone: 937310007 phoneExt: 0007 email: joanparera@osteopatiaterrassa.com lat: 41.56667 lon: 2.01667 hasResults: False
nctId: NCT06389175 id: BON001 id: KR 4555/10-1 type: OTHER_GRANT domain: Deutsche Forschungsgemeinschaft (DFG) briefTitle: Non-invasive Vagus Nerve Stimulation as a Tool to Modulate Stomach-Brain Coupling in Depression overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-12 date: 2026-12 date: 2024-04-29 date: 2024-04-29 name: University of Bonn class: OTHER name: University Hospital Tuebingen briefSummary: The overarching goal of the project is to determine whether differences in stomach-brain coupling contribute to key symptoms of major depressive disorder (MDD) and whether transcutaneous non-invasive vagus nerve stimulation (tVNS) may serve as a non-invasive intervention to improve aberrant interoceptive signaling in participants suffering from MDD. conditions: Depressive Disorder, Major studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 80 type: ESTIMATED name: Transcutaneous non-invasive vagus nerve stimulation (tVNS) name: Sham stimulation measure: Stimulation-induced acute changes in stomach-brain coupling measure: Stimulation-induced acute changes in gastric motility measure: Stimulation-induced mid-term changes in gastric motility measure: Stimulation-induced mid-term changes in self-reported interoception measure: Stimulation-induced mid-term changes in somatic symptoms measure: Stimulation-induced mid-term changes in depressive symptoms measure: Stimulation-induced acute neural changes in food cue reactivity measure: Stimulation-induced acute behavioral changes in invigoration measure: Stimulation-induced acute neural changes during foraging measure: Stimulation-induced acute behavioral changes in foraging decisions measure: Stimulation-induced mid-term changes in positive and negative affect measure: Stimulation-induced mid-term changes in self-reported interoception measure: Stimulation-induced mid-term changes in motivation measure: Stimulation-induced mid-term changes in physical activity measure: Stimulation-induced mid-term changes in heart rate measure: Stimulation-induced acute changes in blood parameters measure: Stimulation-induced mid-term changes in blood parameters measure: Stimulation-induced mid-term changes in composition of microbiome measure: Stimulation-induced mid-term changes in discounting-related decision-making measure: Stimulation-induced mid-term changes in reward learning measure: Stimulation-induced mid-term changes in loneliness sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT hasResults: False
nctId: NCT06389162 id: UNLV-2024-115 briefTitle: Dorsolateral Prefrontal Cortex Transcranial Direct Current and Muscle Fatigue Stimulation on Muscle Fatigue overallStatus: ENROLLING_BY_INVITATION date: 2024-04-04 date: 2024-08-31 date: 2024-09-30 date: 2024-04-29 date: 2024-04-29 name: University of Nevada, Las Vegas class: OTHER briefSummary: The goal of this clinical trial is to learn if transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) can impact muscle fatigue. The main questions it aims to answer are:
Performing two experimental sessions held 3-10 days apart (usually 7 days) Perform a 9 hole pegboard test, maximum voluntary contractions, and a fatiguing contraction. conditions: Fatigue studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: Double-blind whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 20 type: ESTIMATED name: transcranial direct current stimulation measure: Time to Task Failure measure: Fatigue Index measure: Average EMG activity measure: Force error measure: Standard deviation of force measure: 9 Hole Pegboard Test sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: University of Nevada Las Vegas city: Las Vegas state: Nevada zip: 89154 country: United States lat: 36.17497 lon: -115.13722 hasResults: False
nctId: NCT06389136 id: M24-601 briefTitle: A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab acronym: Switch-Up overallStatus: NOT_YET_RECRUITING date: 2024-05-24 date: 2025-08-22 date: 2026-03-09 date: 2024-04-29 date: 2024-04-29 name: AbbVie class: INDUSTRY briefSummary: Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not be enough to control the AD in trial participants who require systemic anti-inflammatory treatment. This study aims to provide data on the efficacy and safety of upadacitinib at different doses in adult participants with moderate to severe AD.