hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06326892 id: CHR1-101-2024 briefTitle: Natural Orifice Specimen Extraction in Low Rectal Cancer Surgery acronym: NOSES overallStatus: RECRUITING date: 2023-07-31 date: 2024-04-30 date: 2024-10-15 date: 2024-03-22 date: 2024-03-25 name: Istituto Clinico Humanitas class: OTHER briefSummary: This study aims to compare the postoperative outcomes of low rectal cancer patients who underwent surgery with Natural Orifice Specimen Extraction (NOSE) versus traditional Pfannenstiel extraction. conditions: Rectal Cancer conditions: Surgery studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 350 type: ESTIMATED name: Natural Orifice Specimen Extraction (NOSE) name: Traditional specimen extraction measure: Surgical Site Infections (SSI) measure: Opioid rescue measure: Postoperative pain measure: Postoperative ileus measure: Incisional hernia measure: Overall postoperative complications sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Humanitas Research Hospital status: RECRUITING city: Rozzano state: MI zip: 20089 country: Italy name: Annalisa Maroli, PhD role: CONTACT phone: 02 8224 7776 phoneExt: 0039 email: colorapp@humanitas.it name: Stefano De Zanet, MS role: CONTACT phone: 02 8224 4623 phoneExt: 0039 email: colorapp@humanitas.it lat: 45.38193 lon: 9.1559 hasResults: False
nctId: NCT06326879 id: 3527 briefTitle: A Comparative Study Between Early Onset Colorectal Cancer and Late Onset Colorectal Cancer Patients acronym: EOrOS overallStatus: RECRUITING date: 2023-11-30 date: 2026-12-31 date: 2027-10-30 date: 2024-03-22 date: 2024-03-25 name: Istituto Clinico Humanitas class: OTHER briefSummary: This study aims to investigate the clinical, socioeconomic, behavioral, genetic, and molecular factors characterizing Early Onset Colorectal Cancer (EOCRC) patients compared with Late Onset Colorectal Cancer (LOCRC) patients conditions: Colorectal Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 340 type: ESTIMATED name: No intervention measure: Incidence rate ratio of colorectal cancer recurrence measure: Correlation between lifestyle and incidence rate of colorectal cancer recurrence measure: Correlation between genetic profile and incidence rate of colorectal cancer recurrence measure: Correlation between molecular profile and incidence rate of colorectal cancer recurrence measure: Correlation between socioeconomic characteristics and incidence rate of colorectal cancer recurrence sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Humanitas Research Hospital status: RECRUITING city: Rozzano state: MI zip: 20089 country: Italy name: Annalisa Maroli, PhD role: CONTACT phone: 02 8224 7776 phoneExt: 0039 email: colorapp@humanitas.it name: Stefano De Zanet, MS role: CONTACT phone: 02 8224 4623 phoneExt: 0039 email: colorapp@humanitas.it lat: 45.38193 lon: 9.1559 hasResults: False
nctId: NCT06326866 id: E-74555795-050.04-941208 briefTitle: Otoacoustic Emissions in Different Blood Types overallStatus: COMPLETED date: 2024-02-07 date: 2024-03-12 date: 2024-03-18 date: 2024-03-22 date: 2024-03-26 name: Istanbul University - Cerrahpasa (IUC) class: OTHER briefSummary: The objective of this study is to examine whether ABO and Rhesus (Rh) blood group systems have an association with distortion product otoacoustic emission (DPOAE) and transient otoacoustic emission (TEOAE) amplitudes with the hypothesis of blood groups may affect hearing thresholds. conditions: Hearing Loss, Cochlear studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 70 type: ACTUAL name: Otoacoustic emissions (non-invasive) measure: Signal to noise ratios sex: ALL minimumAge: 18 Years maximumAge: 26 Years stdAges: ADULT facility: Eyyup KARA city: İstanbul zip: 34107 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06326853 id: Adipofisi briefTitle: Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-03 date: 2026-12 date: 2024-03-22 date: 2024-03-25 name: IRCCS San Raffaele class: OTHER briefSummary: The goal of this observational study is to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary pathologies, and to evaluate the potential beneficial effect of surgical and medical treatments with agonists and antagonists of hypothalamic neuropeptides, currently available, on the development and treatment of adiposity and negative cross-talk between adiposity and muscle/bone tissue conditions: Endocrine Disorders conditions: Adiposity conditions: Pituitary Adenoma conditions: Cushing Syndrome conditions: Acromegaly conditions: Hypopituitarism studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 200 type: ESTIMATED measure: Rate of patients with BMI greater than 30 with hypothalamic-pituitary pathologies sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06326840 id: 98107 briefTitle: Clinical Efficacy and Adverse Reactions of Antipsychotic Treatment overallStatus: COMPLETED date: 2010-05-31 date: 2011-06-10 date: 2011-06-10 date: 2024-03-22 date: 2024-03-22 name: Taipei Medical University Hospital class: OTHER name: Taipei Medical University briefSummary: The goal of this clinical trial is to explore the potential of metformin in managing olanzapine-induced metabolic disturbance and hyperprolactinemia in patients with schizophrenia. The main questions it aims to answer are:
Participants will receive metformin 1500 mg/day for 8 weeks and assessments every 2 weeks. conditions: Metabolic Disturbance conditions: Hyperprolactinemia conditions: Schizophrenia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 42 type: ACTUAL name: Metformin measure: Glucose level measure: prolactin level measure: Insulin level measure: low-density lipoprotein cholesterol (LDL-C) level measure: high-density lipoprotein cholesterol (HDL-C) level measure: cholesterol level measure: triglycerides level measure: leptin level measure: Clinical Global Impression scale sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Taipei Medical University-Wan Fang Hospital city: Taipei zip: 116 country: Taiwan lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06326827 id: P231127IBSORTHO briefTitle: In'Oss™ (MBCP® Putty) Ortho overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-05 date: 2026-08 date: 2024-03-22 date: 2024-03-29 name: Advanced Medical Solutions Ltd. class: INDUSTRY briefSummary: Study of the osteoconductive potential of the injectable bone substitute In'Oss™ (MBCP® Putty) in the filling of orthopaedic bone defects to collect Post-Market Clinical Follow-up (PMCF) data for the CE-marked In'Oss™ (MBCP® Putty) device in the orthopaedic trauma surgery conditions: Orthopedic Disorder conditions: Trauma Injury conditions: Extremity Injury studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: In'Oss™ (MBCP® Putty) measure: Successful bone defect reconstruction in the extremities measure: Evaluation of functional mobility restoration in the extremities with PRO measures measure: Evaluation of patient's pain intensity with VAS pain scale measure: Evaluation of safety of In'Oss measure: Evaluation of device usability sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06326814 id: TDU16837 id: U1111-1298-7281 type: REGISTRY domain: ICTRP briefTitle: A Study to Test if SAR443809 is Tolerated and Safe When Taken as a Single Dose in Healthy Adults overallStatus: COMPLETED date: 2021-10-11 date: 2023-05-05 date: 2023-05-05 date: 2024-03-22 date: 2024-03-22 name: Sanofi class: INDUSTRY briefSummary: Primary objective
* The immunogenicity of SAR443809 conditions: Paroxysmal Nocturnal Hemoglobinuria studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 54 type: ACTUAL name: Humanized anti-Factor Bb monoclonal antibody name: Placebo measure: Number of participants with adverse events (AEs)/treatment-emergent adverse events (TEAEs) measure: Incidence of potentially Clinical laboratory abnormalities measure: PK parameters of SAR443809 for IV and SC administrations: Maximum plasma concentration observed (Cmax measure: PK parameters of SAR443809 for IV and SC administrations: First time to reach Cmax (tmax measure: PK parameters of SAR443809 for IV and SC administrations: Area under the plasma concentration versus time curve calculated using the trapezoidal method from time zero to tlast (AUClast) measure: PK parameters of SAR443809 for IV and SC administrations: Area under the plasma concentration versus time curve extrapolated to infinity (AUC0-∞) measure: PK parameters of SAR443809 for IV and SC administrations: Terminal half-life associated with the terminal slope (λz) (t1/2z) measure: PK parameters of SAR443809 for IV and SC administrations: Time corresponding to the last concentration above the limit of quantification (Clast tlast) measure: PK parameters of SAR443809 for IV and SC administrations: total body clearance of a drug from the plasma calculated by dividing dose by AUC (CL) measure: PK parameters of SAR443809 for SC administrations: apparent total body clearance of the SC formulation (CL/F) measure: PK parameters of SAR443809 for IV and SC administrations: volume of distribution at steady-state (Vss) measure: PK parameters of SAR443809 for SC administrations: apparent volume of distribution at steady-state (Vss/F) measure: PK parameters of SAR443809 for SC administrations: absolute bioavailability (F) measure: Complement alternative pathway activity (Wieslab AP and alternative pathway hemolytic activity [AH50]) measure: Complement classical pathway activity (Wieslab CP) measure: Incidence of treatment -emergent Anti-SAR443809 antibodies sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Parexel International Site Number : 8400002 city: Glendale state: California zip: 91206 country: United States lat: 34.14251 lon: -118.25508 facility: Parexel International Site Number : 8400003 city: Baltimore state: Maryland zip: 21255 country: United States lat: 39.29038 lon: -76.61219 hasResults: False
nctId: NCT06326801 id: REC/014220 Muhammad Iqbal briefTitle: Resistive Diaphragmatic Breathing Exercise With Pursed Lips Breathing Exercise in Sub-acute Stroke Patients overallStatus: COMPLETED date: 2023-09-01 date: 2024-01-15 date: 2024-01-18 date: 2024-03-22 date: 2024-03-22 name: Riphah International University class: OTHER briefSummary: To determine whether resistive diaphragmatic breathing exercise with pursed lips breathing exercise improve pulmonary function in sub-acute ischemic stroke, To determine whether resistive diaphragmatic breathing exercise with pursed lips breathing exercise improve Trunk Control in sub-acute ischemic stroke, To determine whether resistive diaphragmatic breathing exercise with pursed lips breathing exercise improve Functional Capacity in sub-acute ischemic stroke conditions: Stroke, Ischemic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 27 type: ACTUAL name: Resistive Diaphragmatic breathing exercise name: Diaphragmatic breathing exercise name: Conventional stroke physiotherapy measure: pulmonary function measure: Trunk Control measure: Functional Capacity sex: ALL minimumAge: 40 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Northwest General Hospital, Peshawar; city: Peshawar state: Punjab zip: 44000 country: Pakistan lat: 34.008 lon: 71.57849 hasResults: False
nctId: NCT06326788 id: 3912 Mehnoor Butt briefTitle: Effects of Moderate Intensity Soleus Push-ups vs Sustained Soleus Push-ups on Lipid Profile Among Young Population overallStatus: RECRUITING date: 2023-10-01 date: 2024-07-28 date: 2024-07-30 date: 2024-03-22 date: 2024-03-22 name: Riphah International University class: OTHER briefSummary: To determine the effects of Short duration moderate intensity soleus push- ups VS Sustained Soleus Push-ups on lipid profile among Young Population. conditions: Health Behavior studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE whoMasked: PARTICIPANT count: 33 type: ESTIMATED name: Short Duration Moderate Intensity Soleus Push-ups name: SUSTAINED SOLEUS PUSH-UPS measure: Change in Lipid Profile measure: Adherence to Exercise Protocol sex: ALL minimumAge: 18 Years maximumAge: 26 Years stdAges: ADULT facility: Riphah Rehabilitation Center status: RECRUITING city: Islamabad zip: 46600 country: Pakistan name: Mehnoor Butt, MSPT role: CONTACT phone: 335 5400831 email: mehnoorarshad1109@gmail.com name: Waqar Ahmed Awan, PHD role: CONTACT phone: 333 5348846 email: waqar.ahmed@riphah.edu.pk lat: 33.72148 lon: 73.04329 hasResults: False
nctId: NCT06326775 id: KY20240311-KS-02 briefTitle: Research on Precision Pharmaceutical Care for Heart Transplant Recipients overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-12 date: 2026-12 date: 2026-12 date: 2024-03-22 date: 2024-03-22 name: Nanjing First Hospital, Nanjing Medical University class: OTHER name: Wuhan Union Hospital, China name: Changhai Hospital name: Shanghai Zhongshan Hospital briefSummary: Establishing personalized dose prediction and related adverse drug reaction prediction models for immunosuppressive drugs after heart transplantation using multiple methods to construct a precise pharmaceutical service system for heart transplant patients has important research value and clinical significance in improving the safety and effectiveness of medication for patients. conditions: Heart Transplant Patients studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: RETROSPECTIVE count: 500 type: ESTIMATED measure: Steady state whole blood trough concentration of tacrolimus sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Pharmacy Department of Nanjing First Hospital city: Nanjing state: Jiangsu zip: 210006 country: China lat: 32.06167 lon: 118.77778 hasResults: False
nctId: NCT06326762 id: younes briefTitle: Gap CO2 in Septic Patient to Predict Cardiomyopathy Septic overallStatus: COMPLETED date: 2023-01-01 date: 2023-10-30 date: 2023-10-30 date: 2024-03-22 date: 2024-03-22 name: Mohammed VI University Hospital class: OTHER briefSummary: the investigators included 98 patients admitted for sepsis and septic shock (68.4% men, 31.6% women) with an average age of 60.42 years ± 15.13, ranging from 21 to 96 years. The average length of hospital stay was 7.53 days. The most noted medical histories were diabetes (38.8%), hypertension (28.6%), and renal insufficiency (17.1%). Regarding laboratory findings: the mean white blood cell count was 15,985.16 cells/mm³, the mean C-reactive protein (CRP) level was 227.69 mg/L, and the mean procalcitonin level was 50.43 µg/L. In terms of blood gas analysis: the mean lactate level was 3.67 mmol/L, and the mean PCO2 gap (DELTAPCO2) was 4.85. All our patients were continuously monitored by pulse wave analysis: the mean cardiac output was 5.69 L/min, and the mean cardiac index was 4.14 L/s/m² All our patients underwent an echocardiogram, which is a routine examination in our department and is performed at the patient's bedside. The average left ventricular ejection fraction (LVEF) was 51.73%, and the average subaortic peak velocity (ITV) was 14.66 cm.
Subsequently. the investigators examined the clinical and paraclinical profile of patients with septic cardiomyopathy. the investigators identified 19 patients with this condition, while 79 patients did not exhibit cardiac involvement. The percentage was significantly higher in the population with cardiac involvement, accounting for 28.3%. Among the patients with cardiac involvement, 76.5% had a PCO2 gap (DELTAPCO2) ≥ 6 mmHg, a significantly reduced cardiac output with an average of 3.3 L/min, and a predominantly low cardiac index, with 64.3% having an index \< 2.2 L/min/m². The mortality rate was significantly increased at 73.7%. conditions: Gap co2 conditions: Cardiac Output, Low conditions: Cardiac Defect studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 98 type: ACTUAL name: comparaison measure: gapCO2 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: younes Oujidi city: Berkane zip: 9999 country: Morocco lat: 34.92 lon: -2.32 hasResults: False
nctId: NCT06326749 id: 2024/19 briefTitle: Effectiveness of Modified Graded Motor Imagery Training in Stroke Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-11-15 date: 2025-03-15 date: 2024-03-22 date: 2024-03-22 name: Inonu University class: OTHER briefSummary: In the study, movement observation training, Modified Graded Motor Imaging Training, which includes upper extremity functional exercises, and Graded Motor Imaging Training, where the standard protocol is applied, will be used in stroke patients to improve their upper extremity motor functions and daily lives. It is aimed to present it on an evidence-based basis by investigating its effects on Daily Living Activity, quality of life, upper extremity-specific right/left lateralization performance, mental stopwatch performance and motor imagery skills. conditions: Graded Motor Imagery conditions: Stroke conditions: Action Observation Training conditions: Motor Imagery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 21 type: ESTIMATED name: Modified Graded Motor Imagery and Conventional Treatment Group name: Graded Motor Imagery and Conventional Treatment Group name: Conventional Treatment Group measure: Fugl-Meyer Upper Extremity Motor Rating Scale measure: Wolf Motor Function Test (WMFT) measure: Modified Barthel Index measure: Stroke-Specific Quality of Life Scale measure: Lateralization Assessment measure: Mental Chronometry Time measure: Kinesthetic and Visual Imagery Questionnaire (KGIA) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Inonu University city: Malatya zip: 44280 country: Turkey name: Havva ADLI role: CONTACT phone: 05369831133 email: h.adli@hotmail.com name: Kezban BAYRAMLAR, Prof. Dr. role: SUB_INVESTIGATOR lat: 38.35018 lon: 38.31667 hasResults: False
nctId: NCT06326736 id: 2024NZKY-014-02 briefTitle: Study of Neoantigen mRNA Vaccines in Patients With Resectable Pancreatic Cancer overallStatus: RECRUITING date: 2024-04 date: 2025-12 date: 2026-12 date: 2024-03-22 date: 2024-03-22 name: Jinling Hospital, China class: OTHER name: Jiangsu Synthgene Biotechnology Co.Ltd. briefSummary: The purpose of this study is to evaluate the safety and efficacy of treating pancreatic cancer with surgery to remove cancerour tissue, followed by camrelizumab and a personalized cancer mRNA vaccines. conditions: Pancreatic Cancer studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: Surgery name: Camrelizumab name: SJ-Neo006 name: Gemcitabine+Abraxane measure: Incidence of Treatment Emergent Adverse Events (TEAEs) measure: Disease control rate (DCR) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Wang Sizhen status: RECRUITING city: Nanjing state: Jiangsu country: China name: wu qiong role: CONTACT phone: 02580863234 lat: 32.06167 lon: 118.77778 hasResults: False
nctId: NCT06326723 id: SIM0808-101 briefTitle: Investigate the PK, Safety, and Tolerability After Single and Multiple Dose Daridorexant in Chinese Healthy Subjects overallStatus: COMPLETED date: 2023-09-04 date: 2023-12-24 date: 2024-02-05 date: 2024-03-22 date: 2024-03-22 name: Jiangsu Simcere Pharmaceutical Co., Ltd. class: INDUSTRY briefSummary: This clinical study is a single-center, randomized, double-blind, placebo-controlled Phase 1 clinical study to assess the PK characteristics and safety and tolerability of single and multiple dose daridorexant in 32 healthy adult Chinese subjects. conditions: Healthy Volunteer studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 32 type: ACTUAL name: Daridorexant measure: Pharmacokinetic Endpoints1 measure: Pharmacokinetic Endpoints2 measure: Pharmacokinetic Endpoints3 measure: Pharmacokinetic Endpoints4 measure: Pharmacokinetic Endpoints5 measure: Pharmacokinetic Endpoints6 measure: Pharmacokinetic Endpoints7 measure: Safety Endpoints1 measure: Safety Endpoints2 measure: Safety Endpoints3 measure: Safety Endpoints4 measure: Safety Endpoints5 measure: Safety Endpoints6 measure: Safety Endpoints7 measure: Safety Endpoints8 sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Nanjing Drum Tower hospital city: Nanjing state: Jiangsu zip: 210000 country: China lat: 32.06167 lon: 118.77778 hasResults: False
nctId: NCT06326710 id: P0045122 briefTitle: The 'Outdoor Rehab-Fit' App-based Physical Activity Education Intervention for Frail Older Adults in Hong Kong overallStatus: RECRUITING date: 2024-04-01 date: 2024-10-01 date: 2024-12-31 date: 2024-03-22 date: 2024-04-09 name: The Hong Kong Polytechnic University class: OTHER briefSummary: In recent years, research teams around the world have developed interventions to educate older adults to use outdoor exercise facilities (OEFs) to improve health outcomes like strength, balance, mobility, PA level, and weight. These interventions employed trainers or therapists to instruct, and monitor exercise training for older adults using the public accessible OEFs. Apart from therapist or trainer-led intervention, an Australian research team developed a mobile application, and social support strategies to help participants to use OEFs to enhance their aerobic and resistance-based PA.
A recent local in-depth qualitative study discovered that OEFs in Hong Kong attracted frailer older adults (i.e., those who recovered from a major illness or who has chronic diseases), and their caregivers to use OEFs to support and maintain their daily PA behavior. Some used OEFs to complement their formal rehabilitation sessions. It appears that OEFs in Hong Kong serves as an important health maintenance space for frailer older adults in the city to "age in place", yet educational training related to OEFs has been lacking over the years. Signage besides the exercise equipment has been the only education material for users over the years.