hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06262646 id: NTEC-2023-677 briefTitle: Video-conferencing FACT for Young Children With Special Needs overallStatus: RECRUITING date: 2024-02-01 date: 2025-01-31 date: 2026-01-31 date: 2024-02-16 date: 2024-02-16 name: Chinese University of Hong Kong class: OTHER name: Hong Kong Christian Service name: Hong Kong Federation of Youth Groups name: Hong Kong Young Women's Christian Association name: Yang Memorial Methodist Social Service name: Hong Kong Sheng Kung Hui Welfare Council briefSummary: Objective: This RCT evaluates the efficacy of Focused Acceptance and Commitment Therapy (FACT) delivered via videoconferencing for parents of special needs children, targeting reducing parental stress (primary outcome), symptoms of depression and anxiety, as well as psychological flexibility.
Conclusion: By leveraging videoconferencing for therapy delivery, the RCT aims to improve access to mental health interventions and emphasize the importance of psychological health among parents of special needs children. This could foster greater recognition and proactive management of mental health within this population. conditions: Autism Spectrum Disorder conditions: Attention Deficit Hyperactivity Disorder conditions: Specific Learning Disorder conditions: Communication Disorders conditions: Motor Disorders studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two-arm Randomised Controlled Trial (RCT) with a repeated-measures parallel-group design primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: Eligible parents consenting to participate will be randomly assigned to either the FACT or Control Group in a 1:1 ratio, using the permuted block size of 6 through sequentially numbered, opaque and sealed envelopes with number cards (1=intervention, 2=control). A separate set of random numbers, concealed from the research team and RAs, will be generated by a statistician. Clerical staff uninvolved in the project will administer the randomisation. The research assistant (RA-1), blinded to subject selection, will open the envelopes only after informed consent and baseline assessments are completed. The research assistant (RA-2) is also blinded to group assignments and will conduct assessments/evaluations. whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 253 type: ESTIMATED name: Focused Acceptance and Commitment Therapy name: Control Group measure: Parenting stress measure: Parental depressive symptoms measure: Parental anxiety symptoms measure: Parental Psychological Flexibility measure: ACT Core Process Utilization sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Chinese University of Hong Kong status: RECRUITING city: Hong Kong country: Hong Kong name: Pui Tik YAU role: CONTACT phone: (852) 3943-9915 email: jamyau@cuhk.edu.hk lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06262633 id: CRE-2023.079 briefTitle: A Multi-centre Trial on Targeted Microwave Ablation (TMA) for Localized Prostate Cancer overallStatus: RECRUITING date: 2024-03-15 date: 2026-04-30 date: 2026-06-30 date: 2024-02-16 date: 2024-03-19 name: Chinese University of Hong Kong class: OTHER briefSummary: This study is to investigate the efficacy of Targeted Microwave Ablation (TMA) under MRI-Ultrasound fusion and organ-based tracking (OBT) navigation in localized prostate cancer (PCa) in a multi-centre trial. conditions: Prostate Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 103 type: ESTIMATED name: Targeted Microwave Ablation (TMA) for localized prostate cancer using organ based tracking (OBT) navigation measure: The oncological control of prostate cancer measure: Cancer detection on biopsy of each ablated MRI visible lesion measure: Cancer detection on biopsy of each ablated MRI invisible lesion measure: Gleason 4 or 5 cancer detected on biopsy of ablated area measure: Out-of-field recurrence: Any cancer outside treated area on systematic biopsy measure: Common Terminology Criteria for Adverse Events (CTCAE) v5.0 measure: PSA change measure: Urinary Symptoms after treatment measure: Sexual side effects after treatment measure: Continence side effects after treatment measure: Common Terminology Criteria for Adverse Events (CTCAE) rectal toxicity measure: Quality of life measured by ED-5Q-5Lquestionnaire measure: Quality of life in patients with prostate cancer measured by EPIC-26 measure: Quality of life measured by QLQ-C30, sex: MALE minimumAge: 45 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peter Ka-Fung CHIU status: RECRUITING city: Sha Tin country: Hong Kong name: Peter Ka-Fung CHIU, PhD,MBChB role: CONTACT phone: 35052625 email: peterchiu@surgery.cuhk.edu.hk lat: 22.38333 lon: 114.18333 hasResults: False
nctId: NCT06262620 id: 2022-NHLHCRF-LX-01-0201-06 briefTitle: The Comparisonof Mediastinal/Hilar Lymph Node Biopsies by EBUS-TBNA, EBUS-TBCB, and EBUS-TBFB overallStatus: NOT_YET_RECRUITING date: 2024-02-18 date: 2026-02-18 date: 2026-02-18 date: 2024-02-16 date: 2024-02-16 name: China-Japan Friendship Hospital class: OTHER briefSummary: The goal of this prospective, multi-centre, randomised controlled clinical study is to compare the diagnostic efficacy and safety of the three biopsy techniques (EBUS-TBNA, EBUS-TBCB, and EBUS-TBFB) in mediastinal/hilar lymph node biopsies.
Researchers will compare the adequacy of sampling by the three biopsy techniques, their sample quality, diagnostic rate, and incidence of each adverse events. conditions: Lymphadenopathy Hilar conditions: Lymphadenopathy Mediastinal studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 723 type: ESTIMATED name: EBUS-TBNA name: EBUS-TBCB name: EBUS-TBFB measure: Dignostic rate of EBUS-TBNA, EBUS-TBCB, and EBUS-TBFB measure: Incidence rate of adverse events measure: the adequacy of sample acquisition measure: the quality of sample acquisition sex: ALL minimumAge: 15 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06262607 id: CLE400-NP-201 briefTitle: A Study of CLE-400 (Topical Gel) for the Treatment of Chronic Pruritus in Adult Subjects With Notalgia Paresthetica overallStatus: RECRUITING date: 2024-01-29 date: 2024-12-31 date: 2025-01-15 date: 2024-02-16 date: 2024-04-17 name: Clexio Biosciences Ltd. class: INDUSTRY briefSummary: This is a Phase 2, randomized, double-blind, vehicle-controlled study to assess the efficacy and safety of CLE-400 topical gel for the treatment of chronic pruritus in adult subjects with Notalgia Paresthetica (NP). conditions: Chronic Pruritus in Adult Subjects With Notalgia Paresthetica (NP) studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 40 subjects, 2 arms, parallel primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: double whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 40 type: ESTIMATED name: CLE-400 name: Vehicle measure: Percent change from baseline in weekly mean of the daily 24-hour Worst Itch-Numeric Rating Scale (WI-NRS) score at Week 4. sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clinical site 11 status: RECRUITING city: Bryant state: Arkansas zip: 72022 country: United States lat: 34.59593 lon: -92.48905 facility: Clinical site 01 status: RECRUITING city: Coral Gables state: Florida zip: 33134 country: United States lat: 25.72149 lon: -80.26838 facility: Clinical Site 10 status: RECRUITING city: North Miami Beach state: Florida zip: 33116 country: United States lat: 25.93315 lon: -80.16255 facility: Clinical Site 02 status: RECRUITING city: Indianapolis state: Indiana zip: 46250 country: United States lat: 39.76838 lon: -86.15804 facility: Clinical Site 23 status: RECRUITING city: Methuen state: Massachusetts zip: 01844 country: United States lat: 42.7262 lon: -71.19089 facility: Clinical Site 09 status: RECRUITING city: Dublin state: Ohio zip: 43016 country: United States lat: 40.09923 lon: -83.11408 facility: Clinical site 16 status: RECRUITING city: Houston state: Texas zip: 77004 country: United States lat: 29.76328 lon: -95.36327 facility: Clinical Site 06 status: RECRUITING city: San Antonio state: Texas zip: 78213 country: United States lat: 29.42412 lon: -98.49363 hasResults: False
nctId: NCT06262594 id: L'ÉTOILE briefTitle: Lemborexant Treatment of Insomnia Linked to Epilepsy acronym: L'ÉTOILE overallStatus: NOT_YET_RECRUITING date: 2024-02-08 date: 2025-02-08 date: 2026-02-08 date: 2024-02-16 date: 2024-02-16 name: University of Manitoba class: OTHER name: Duke University briefSummary: The goal of this clinical trial is to assess whether Lemborexant can improve sleep in patients with epilepsy. conditions: Epilepsy conditions: Sleep studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 26 type: ESTIMATED name: Lemborexant measure: WASO sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06262568 id: Soh-Med-23-03-18MS briefTitle: Effect of Guidelines on Nurses' Awareness Toward HRP and Maternal Near Miss Cases overallStatus: RECRUITING date: 2023-04-01 date: 2024-03-01 date: 2024-06-01 date: 2024-02-16 date: 2024-02-16 name: Sohag University class: OTHER briefSummary: The current study will evaluate the impact of awareness of maternity nurses toward instructional guidelines and evaluate the knowledge, practice and attitude of nurses toward high risk pregnancy and maternal near miss cases before and after education. conditions: High Risk Pregnancy and Maternal Near Miss Cases studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: OTHER count: 71 type: ESTIMATED name: assess the nurse knowledge and practices. measure: Evaluate the outcome of instructional guidelines on maternity nurses' awareness toward high-risk pregnancy and Maternal Near Miss Cases by questionnaire before and after training sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Sohag University hospitals status: RECRUITING city: Sohag country: Egypt name: ghona Abd EL-Nasser, Professor role: CONTACT phone: 01123067894 email: mahmoud.hazem@nursing.sohag.edu.eg lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06262555 id: TYGH111061 briefTitle: Novel Light Delivery Method for Performing Transbronchial Photodynamic Therapy for Peripheral Lung Cancer overallStatus: RECRUITING date: 2024-03 date: 2024-06-30 date: 2024-12-31 date: 2024-02-16 date: 2024-02-16 name: Taoyuan General Hospital class: OTHER_GOV briefSummary: This research aims to develop an innovative photodynamic therapy (PDT) for peripheral lung tumors. Current treatments involve surgery, chemotherapy, and radiation. Photodynamic therapy, using light and photosensitizing drugs, is promising but has limitations. Our team proposes using Lipiodol, a contrast agent, instilled into the trachea via bronchoscopy, surrounding the tumor. Preliminary pig model trials showed safety. Clinical trials, building on a U.S. study (NCT02916745), commenced in October 2021, treating three cases. Initial results suggest safety, but efficacy requires further investigation. Based on ongoing trials, we propose a phase I trial with multiple light treatments from different directions and an additional dose after 48 hours to assess safety and efficacy. This study will guide future clinical trials for optimal PDT dosage. conditions: Lung Cancer conditions: Lung Cancer Metastatic studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 3 type: ESTIMATED name: Transbronchial PDT peripheral lung tumor ablation measure: Technical Feasibility measure: Technical Safety measure: Tumor remission rate sex: ALL minimumAge: 20 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Taoyuan General Hospital, Ministry of Health and Welfare status: RECRUITING city: Taoyuan City zip: 320 country: Taiwan name: Yei-San Hsieh, MD role: CONTACT phone: +886-975061108 email: yeisanh@gmail.com name: Yei-San Hsieh, Dr. role: PRINCIPAL_INVESTIGATOR name: Hwi-Lu Chang, Dr. role: SUB_INVESTIGATOR lat: 24.95233 lon: 121.20193 hasResults: False
nctId: NCT06262542 id: 111016 briefTitle: Efficacy and Safety of Chinese Herb Medicine-Moxibustion Therapy on Chemotherapy-Induced Leukopenia overallStatus: RECRUITING date: 2024-03-13 date: 2024-12-31 date: 2024-12-31 date: 2024-02-16 date: 2024-04-12 name: Taichung Armed Forces General Hospital class: OTHER_GOV briefSummary: Cancer is the second leading cause of death globally, with an estimated 9.6 million deaths in 2018, accounting for one-sixth of total deaths. The economic burden of cancer continues to rise globally, causing significant physiological, psychological, and economic pressures on individuals, families, communities, and healthcare systems. The toxic effects of chemotherapy, such as nausea, vomiting, decreased blood cells, fatigue, etc., can impair patients' function, activities, and quality of life. Chemotherapy-induced leukopenia (CIL), particularly low white blood cell counts (48.9%), is a major concern for cancer patients.
Current conventional treatments primarily involve colony-stimulating factors (G-CSF and GM-CSF) to accelerate neutrophil recovery and regulate granulocyte production. However, G-CSF is costly and adds financial burden, and its use is restricted to cases meeting specific criteria. Additionally, rapid changes in patients' symptoms, weakness, and poor appetite may lead to swift deterioration of their condition, making it challenging to predict and prevent. Moreover, G-CSF has frequent side effects, including skin rash, liver function abnormalities, nausea, vomiting, fever, headache, fatigue, palpitations, and increased levels of ALP, LDH, and uric acid, with bone pain being the most common.
Traditional Chinese Medicine (TCM) has been a long-standing medical practice in Eastern societies and is a legally recognized healthcare option in Taiwan, covered by national health insurance. TCM includes acupuncture, moxibustion, and Chinese herbal medicine, all of which have been researched for their potential in addressing chemotherapy-induced leukopenia. conditions: Cancer, Chemotherapy-induced Leukopenia, Chinese Herb Medicine-moxibustion studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: moxibustion and Chinese herbal medicine group measure: Track the number of white blood cells sex: ALL minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Taichung Armed Force General Hospital status: RECRUITING city: Taichung state: Taiping zip: 411228 country: Taiwan name: ming huei cheng role: CONTACT phone: 0921059072 email: u9630091@cmu.edu.tw lat: 24.1469 lon: 120.6839 hasResults: False
nctId: NCT06262529 id: 22-AOI-06 briefTitle: Neurocognitive Impairment After Ischemic Stroke acronym: COG-TRA-Y MRI overallStatus: RECRUITING date: 2024-02-09 date: 2025-02-09 date: 2027-02-09 date: 2024-02-16 date: 2024-02-16 name: Centre Hospitalier Universitaire de Nice class: OTHER briefSummary: Affecting more than 150,000 patients in France, stroke is a major public health issue and a leading cause of disability worldwide. In western countries, 80-85% of strokes are of ischemic subtype. This study will focus on young adults, aged 18-45, with a diagnosis of ischemic stroke.
Studies assessing post-stroke cognition in young patients reported an alarming prevalence of cognitive impairment, affecting about 60% of stroke survivors between 4 and 12 months after the acute event. However, longitudinal data on neurocognitive trajectories (i.e., the evolution of cognitive impairment over time) in young patients with ischemic stroke are lacking. Collecting such data requires an exhaustive neuropsychological assessment and several functional evaluations, at different times, for the same patient.
Up to date, the clinic-radiological predictors and associated factors of neurocognitive impairment after ischemic stroke in young patients have not been studied. Ischemic stroke causes acute brain lesions of the gray matter (GM) and white matter (WM). Numerous studies suggest that cognitive health may be more closely linked to the integrity of WM than to GM. Magnetic resonance imaging (MRI), and in particular diffusion tensor imaging (DTI) sequences, analyze WM bundles. By using fiber tracking algorithms image analysis enable the WM fiber bundle reconstruction and allow quantifying the volume of lesions (pre-existing and ischemic stroke-induced) in the WM tract.
The aim of this study is to study whether the extension of pre-existing and acute white matter lesions is associated with poorer cognitive recovery after ischemic stroke, both in terms of global cognitive performance and impairment in specific neurocognitive domains. conditions: Acute Ischemic Stroke studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 16 type: ESTIMATED name: Cerebral MRI measure: evolution of neurocognitive disorders (trajectories of global cognitive efficiency) over 1 year after stroke sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: cannes Hospital status: NOT_YET_RECRUITING city: Cannes zip: 06600 country: France name: sylvain LACHAUD role: CONTACT email: s.lachaud@ch-cannes.fr name: Sylvain Lachaud role: PRINCIPAL_INVESTIGATOR lat: 43.55135 lon: 7.01275 facility: Nice University Hospital status: RECRUITING city: Nice zip: 06000 country: France name: Marina Passalboni role: CONTACT phone: 04 92 03 27 90 email: passalboni.m@chu-nice.fr name: barbara CASOLLA role: PRINCIPAL_INVESTIGATOR lat: 43.70313 lon: 7.26608 hasResults: False
nctId: NCT06262516 id: CASE2824 briefTitle: Nephroureterectomy With and Without Lymph Node Dissection for Upper Tract Urothelial Cell Carcinoma overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2027-01-01 date: 2029-01-01 date: 2024-02-16 date: 2024-02-16 name: Case Comprehensive Cancer Center class: OTHER briefSummary: The goal of this study is to conduct the first randomized-controlled trial to determine the oncologic efficacy of lymph node dissection in participants with upper tract urothelial cell carcinoma. The main questions it aims to answer are:
Participants will undergo nephroureterectomy with or without lymph node dissection. Researchers will compare these two groups to determine the oncologic efficacy of performing lymph node dissection. conditions: Urothelial Carcinoma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This study is designed as a 1:1 two armed randomized-controlled trial. primaryPurpose: TREATMENT masking: NONE count: 94 type: ESTIMATED name: Nephroureterectomy name: Lymph Node Dissection measure: Recurrence-free survival measure: Treatment-free survival measure: Cancer-specific survival measure: Overall Survival measure: Time to recurrence measure: Use of adjuvant therapies measure: Perioperative complications sex: ALL minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cleveland Clinic Glickman Urological and Kidney Institute city: Cleveland state: Ohio zip: 44195 country: United States name: Mohamed Eltemamy, MD role: CONTACT phone: 216-444-5888 email: Eltemam@ccf.org lat: 41.4995 lon: -81.69541 hasResults: False
nctId: NCT06262503 id: P.T.REC/012/004810 briefTitle: the Influence of Virtual Reality Approach on Phantom Pain in Trans Tibial Amputation overallStatus: ACTIVE_NOT_RECRUITING date: 2023-10-01 date: 2024-02 date: 2024-03 date: 2024-02-16 date: 2024-02-20 name: Cairo University class: OTHER briefSummary: 1. To investigate the effect of Virtual reality (VR) on phantom limb pain in trans tibial amputation.
A sample size of 60 will be randomly allocated to two groups(30 in each group) , by using computer-generated random number list method. Control group will receive conventional physiotherapy(TENS- Phantom exercises and mirroring exercise) for reducing phantom pain in trans -tibial amputation and the experimental group will receive conventional physiotherapy(TENS- Phantom exercises and mirroring exercise) and Virtual Reality for reducing phantom pain in trans -tibial amputation . conditions: Phantom Pain Following Amputation of Lower Limb studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Group1:conventional physiotherapy for phantom Pain Group2:conventional physiotherapy and Virtual Reality for phantom Pain primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 75 type: ESTIMATED name: Virtual Reality name: Transcutaneous Electrical Nerve Stimulation (TENS) name: Mirroring Therapy name: Phantom Exercises measure: Pain Intensity Level measure: Lower Extremity Functional sex: ALL minimumAge: 18 Months maximumAge: 75 Months stdAges: CHILD facility: Faculty of Physical therapy, Cairo university city: Giza zip: 12613 country: Egypt lat: 30.00808 lon: 31.21093 hasResults: False
nctId: NCT06262490 id: P.T.REC/012/004765 briefTitle: Impact of Pelvic Floor Rehabilitation Combined With Ultrasound Therapy on Osteomyoarticular Symptoms in Chronic Perineal Pain overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-08-01 date: 2024-09-01 date: 2024-02-16 date: 2024-02-16 name: Cairo University class: OTHER briefSummary: The purpose of the study is to find out the effect of pelvic floor rehab combined with ultrasound have effect in chronic perineal pain subjects associated with osteomyoarticular symptoms . conditions: Chronic Perineal Pain conditions: Pelvic Floor Disorders studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: Traditional ultrasound therapy name: Pelvic floor rehabilitation measure: Assessment of osteomyoarticular symptoms measure: Assessment of perineal pain intensity measure: Assessment of pelvic floor muscle strength measure: Assessment of pelvic floor muscle tightness measure: Assessment of lumbar spine mobility sex: FEMALE minimumAge: 20 Years maximumAge: 35 Years stdAges: ADULT facility: Cairo University city: Giza country: Egypt name: Aya T- Allah M. Nabil, PhD student role: CONTACT phone: 01063028038 email: drayanabil1993@gmail.com name: Salwa M. El Badry role: CONTACT name: Amel M. Yousef, Prof. role: PRINCIPAL_INVESTIGATOR name: Hazem S. Al-Ashmawy, Ass. Prof role: PRINCIPAL_INVESTIGATOR lat: 30.00808 lon: 31.21093 hasResults: False