hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06294275 id: P-10-LP001-2022-01 briefTitle: A Study of Single and Multiple Dose Administration of LP-001 in Healthy Subjects overallStatus: ACTIVE_NOT_RECRUITING date: 2022-09-16 date: 2024-01-02 date: 2024-04-06 date: 2024-03-05 date: 2024-03-05 name: Longbio Pharma class: INDUSTRY briefSummary: The purpose of this study is to evaluate safety, tolerability, immunogenicity, pharmacokinetics, pharmacodynamics, and efficacy of LP-001 in healthy volunteers. The study will be conducted in 2 parts: Part 1, the single ascending dose (SAD) is the first in human (FIH) study of LP-001 and Part 2, multiple ascending dose (MAD). conditions: Myelodysplastic Syndrome (MDS) studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 68 type: ESTIMATED name: LP-001 Dose 1 (Single) name: LP-001 Dose 2 (Single) name: LP-001 Dose 3 (Single) name: LP-001 Dose 4 (Single) name: LP-001 Dose 5 (Single) name: LP-001 Dose 6 (Single) name: Placebo (Single) name: LP-001 Dose 7 (Multiple) name: LP-001 Dose 8 (Multiple) name: Placebo (Multiple) measure: Adverse events measure: Time to peak concentration (Tmax) of LP-001 measure: Maximum concentration (Cmax) of LP-001 measure: Elimination half-life (t1/2) of LP-001 measure: Area under the concentration-time curve (AUC0-t) of LP-001 measure: Apparent clearance rate (CL/F) of LP-001 measure: Assessment of immunogenicity measure: Assessment of hemoglobin (Hb) change measure: Assessment of red blood cell (RBC) count change measure: Assessment of reticulocyte (Rtc) count change sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Shanghai Public Health Clinical Center city: Shanghai country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06294262 id: 2023-508230-33-00 briefTitle: Safety, Tolerability, Immunogenicity and Immunological Mechanisms of TETRALITE, a Novel Seasonal Influenza Vaccine acronym: TETRALITE-Ib overallStatus: RECRUITING date: 2024-01-29 date: 2024-09 date: 2025-03 date: 2024-03-05 date: 2024-03-05 name: LiteVax BV class: INDUSTRY name: University Hospital, Ghent name: HarmonyCR, Melle, Belgium briefSummary: The effect of LiteVax Adjuvant supplemented to licensed seasonal influenza vaccine on safety and immunogenicity will be investigated in both younger and older healthy participants. Local and systemic adverse events, and humoral and cellular immune responses will be determined at different time intervals after a single administration. Mode of action of LiteVax Adjuvant will examined by detailed genetic analysis and omics approaches such as transcriptomics, proteomics and metabolomics. conditions: Vaccination Reaction studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 84 type: ESTIMATED name: TETRALITE measure: Characterise local and systemic AEs, and SAEs, pIMDs and AESIs to TETRALITE measure: Characterise clinical hematology and biochemistry to TETRALITE measure: Characterise HI antibody response to the four vaccine strains of TETRALITE in serum measure: Characterise MN antibody response to the four vaccine strains of TETRALITE in serum measure: Characterise mechanisms of action of LiteVax Adjuvant measure: Characterise T-cell responses to TETRALITE in PBMCs measure: Characterise B-cell response to TETRALITE in PBMCs measure: Characterise molecular features of vaccine-induced immunity by RNA sequencing measure: Characterise antibody response to influenza virus antigens other than hemaglutunin of the vaccine strains of TETRALITE sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Gent status: RECRUITING city: Ghent zip: 9000 country: Belgium lat: 51.05 lon: 3.71667 hasResults: False
nctId: NCT06294249 id: 20045125 briefTitle: Pain Severity in Flapless Dental Implant Placement Using Laser overallStatus: COMPLETED date: 2020-01-01 date: 2023-12-01 date: 2023-12-04 date: 2024-03-05 date: 2024-03-26 name: Shiraz University of Medical Sciences class: OTHER name: Shahid Beheshti University of Medical Sciences briefSummary: The goal of this split-mouth randomized clinical trial study was to investigate the effect of using a laser on pain and discomfort following flapless dental implant surgery. It was hypothesized that laser did not have any impact on post-op pain. Therefore, the study aimed to compare pain and discomfort following flapless dental implant surgeries with or without a laser. conditions: Jaw, Edentulous, Partially studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 40 type: ACTUAL name: Laser-induced Incision name: Punch Incision name: Implant Placement measure: Pain Severity sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: shiraz University of medical sciences city: Shiraz state: Fars country: Iran, Islamic Republic of lat: 29.61031 lon: 52.53113 hasResults: False
nctId: NCT06294236 id: SC291-102 briefTitle: Study Evaluating SC291 in Subjects With Severe r/r B-cell Mediated Autoimmune Diseases (GLEAM) overallStatus: RECRUITING date: 2024-04 date: 2027-12 date: 2028-03 date: 2024-03-05 date: 2024-04-01 name: Sana Biotechnology class: INDUSTRY briefSummary: SC291-102 is a Phase 1 study to evaluate SC291 safety and tolerability, preliminary clinical response, cellular kinetics and exploratory assessments for subjects with severe autoimmune diseases. conditions: Lupus Erythematosus conditions: Systemic Lupus Erythematosus conditions: SLE (Systemic Lupus) conditions: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis conditions: Granulomatous Polyangiitis conditions: Microscopic Polyangiitis studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 36 type: ESTIMATED name: SC291 measure: Evaluate safety and tolerability of SC291 measure: Evaluate preliminary clinical response to SC291 measure: Evaluate preliminary clinical response to SC291 measure: Evaluate preliminary clinical response to SC291 measure: Evaluate preliminary clinical response to SC291 measure: Evaluate preliminary clinical response to SC291 (LN and ERL Cohorts) measure: Evaluate preliminary clinical response to SC291 (LN Cohort) measure: Evaluate preliminary clinical response to SC291 (ERL Cohort) measure: Evaluate preliminary clinical response to SC291 (AAV Cohort) measure: Evaluate preliminary clinical response to SC291 (AAV Cohort) measure: Evaluate cellular kinetics and persistence of SC291 sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Swedish Medical Center status: RECRUITING city: Seattle state: Washington zip: 98122 country: United States name: Richie Satira, RN role: CONTACT phone: 206-386-2000 email: richard.satira@swedish.org name: Danna Caceres-Reyes, RN role: CONTACT phone: 206-386-2000 email: Danna.Caceres-Reyes@swedish.org name: Philip J. Mease, MD, MACR role: PRINCIPAL_INVESTIGATOR lat: 47.60621 lon: -122.33207 hasResults: False
nctId: NCT06294223 id: SaglikBilU briefTitle: Upper Extremity and Muscle Oxygenation overallStatus: RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-03-01 date: 2024-03-05 date: 2024-03-18 name: Saglik Bilimleri Universitesi class: OTHER briefSummary: The aim of this study was to measure the acute change in oxygen saturation of skeletal muscle during resistance exercise in the upper extremity using near-infrared spectroscopy. conditions: Near-infrared Spectroscopy conditions: Muscle Oxygenation studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Exercise follow up with near-infrared spectroscopy measure: Determination of Blood Pressure measure: Saturation Measurement measure: Muscle Oxygenation Measurement measure: Determination of Heart Rate sex: ALL minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Saglik Bilimleri University status: RECRUITING city: Istanbul zip: 34010 country: Turkey name: Esra Pehlivan, Ass Prof role: CONTACT phone: 05058527913 email: esra.pehlivan@sbu.edu.tr lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06294210 id: REC202307012 briefTitle: Supporting Secondary School Student Wellbeing Through a Mobile App and Wearable Biofeedback acronym: EWSSS overallStatus: NOT_YET_RECRUITING date: 2024-03-11 date: 2025-06-01 date: 2025-07-01 date: 2024-03-05 date: 2024-03-05 name: Royal College of Surgeons, Ireland class: OTHER briefSummary: This study aims to investigate the effects of an app and wearable device on the wellbeing of secondary school students. The app will offer support for stress management, sleep improvement, and time management. Additionally, it will provide access to educational resources, text-based coaching, and biofeedback monitoring through the wearable device. The device, worn around the wrist, will measure heart rate variability as an indicator of stress response. Throughout the study, students will complete bi-monthly surveys on sleep, stress, and overall wellbeing. To assess the specific impact of each feature, the app features will be released incrementally over the course of a year. The intervention group, comprising students in their last two years of secondary school, will have access to the app and wearable device, while a control group within the same class will not use the system but will complete the same wellness surveys. Coaches on this platform will come from the Centre for Positive Health Sciences MSc in Positive Health Coaching as part of their continued training in coaching. Coaching will be asynchronous so that students can post questions at any time during the day, but coaches will respond within 24 hours, during office hours. It will be made clear that this is not a therapeutic service and will be directed to other resources for these services. Coaches will file an incident report if a risk arises from a message with participants. Participants will be given guidelines for the type of questions they can ask such as asking for advice for setting goals related to their digital habits and sleeping better. The study\'s findings will provide valuable insights into the effectiveness of the app and wearable device in enhancing student wellbeing leading up to their leaving certification exams. conditions: No Disease or Condition is Being Studied conditions: Stress Psychological conditions: Overall Wellness studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: A group of students will be using the mobile app and wrist-monitor to support their wellbeing while a control group of students will be followed at the same time who will not be using the app or wearable. The survey wellbeing, stress, and sleep scores will be compared between these groups. primaryPurpose: BASIC_SCIENCE masking: NONE count: 50 type: ESTIMATED name: Mobile app and wrist-worn monitor measure: Wellbeing Survey Results measure: Heart Rate Variability Metrics measure: Routine check-ins measure: App Engagement sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06294197 id: PhD Thesis briefTitle: Examination of the Effects of Pelvic Floor Exercises on Vaginal and Sexual Health in Postmenopausal Women. overallStatus: RECRUITING date: 2024-01-13 date: 2024-07-13 date: 2024-12-13 date: 2024-03-05 date: 2024-03-05 name: Hatice Gulsah Kurne class: OTHER briefSummary: The purpose of this study; To investigate the effects of pelvic floor muscle exercises on vaginal and sexual health in postmenopausal women. Vaginal symptoms such as vaginal dryness, burning and dyspareunia occur in the postmenopausal period. Vaginal symptoms affect sexual function, leading to a decrease in quality of life. In our study, we plan to evaluate vaginal dryness, one of the vaginal symptoms, using Schirmer's Test. Also in our study; Severities of vaginal dryness, burning and dyspareunia will be evaluated with the visual analog scale (VAS), sexual function will be evaluated with the Post-Menopausal Sexuality Questionnaire and Female Sexual Function Scale, vaginal aging will be evaluated with the Daily Effect of Vaginal Aging Scale, and the presence/severity of pelvic floor symptoms will be evaluated with the Pelvic Floor Distress Inventory-20. The cases will be randomized into two groups and pelvic floor exercises will be given to one group. After the exercises are given, vaginal pH and moistness will be evaluated for acute effect. In the other group, vaginal PH and moisture will be measured after 5 minutes. The cases will be followed without any intervention to the control group. After 12 weeks, the same evaluations will be made to both groups and the results will be compared. The data will be compared using appropriate statistical methods (statistical significance value will be taken as p\<0.05) and discussed with the literature. conditions: Sexual Dysfunction conditions: Postmenopausal Symptoms conditions: Pelvic Floor Muscle Weakness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Parallel Assignment Randomized Healthy Participants primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Pelvic Floor Exercises measure: Schirmer's Test measure: Visual Analogue Scale (VAS) measure: Female Sexual Function Index (FSFI) measure: Postmenopausal Sexuality Questionnaire (PMSQ) measure: Vaginal Daily Impact of Aging Scale (VDIAS) measure: Disturbing Pelvic Floor Inventory-20 measure: Evaluation of Pelvic Floor Muscle Strength sex: FEMALE minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istanbul Training and Research Hospital status: RECRUITING city: Istanbul state: Fatih zip: 34098 country: Turkey name: Nebahat Uzunay, MD role: CONTACT phone: +905052609436 email: nebahatuzunay@gmail.com lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06294184 id: Guangzhou PH tDCS in SD briefTitle: tDCS Interventions for Subthreshold Depressive Symptoms in Young Individuals. overallStatus: RECRUITING date: 2023-11-01 date: 2024-11 date: 2024-12 date: 2024-03-05 date: 2024-03-05 name: Guangzhou Psychiatric Hospital class: OTHER_GOV briefSummary: The purpose of this study is to assess the mechanisms of the effect of transcranial direct current stimulation (tDCS) in alleviating subthreshold depressive symptoms in young individuals, and individualized outcome prediction is carried out. conditions: Subthreshold Depression conditions: Young People conditions: Transcranial Direct Current Stimulation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 150 type: ESTIMATED name: tdcs lDLPFC name: tdcs rVLPFC name: Sham measure: The effect of tDCS in alleviating subthreshold depressive symptoms measure: Neuroaffective mechanisms of tDCS in alleviating subthreshold depressive symptoms measure: To predict the individual effect of tDCS in alleviating subthreshold depressive symptoms sex: ALL minimumAge: 12 Years maximumAge: 25 Years stdAges: CHILD stdAges: ADULT facility: Guangzhou Brain hospital(Guangzhou Huiai Hospital) status: RECRUITING city: Guangzhou state: Guangdong zip: 510370 country: China name: Kangguang Lin, M.D;Ph.D role: CONTACT phone: 86-13560360144 email: klin@gzhmu.edu.cn lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06294171 id: Modified Alveolar Bone Cut briefTitle: Efficacy of Modified Piezosurgery Alveolar Bone Cut With Osseodensification Drills in Expanding Narrow Alveolar Bone overallStatus: COMPLETED date: 2022-11-15 date: 2023-05-01 date: 2023-11-01 date: 2024-03-05 date: 2024-03-05 name: University of Baghdad class: OTHER briefSummary: The aim of the study is to determine the efficacy of modified piezosurgery with osseodensification drills in expanding narrow alveolar bone. conditions: Dental Implant Failed studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 14 type: ACTUAL name: measurement of alveolar ridge width measure: expansion rate measure: expansion rate sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: University of Baghdad College of Dentistry city: Baghdad zip: 10011 country: Iraq lat: 33.34058 lon: 44.40088 hasResults: False
nctId: NCT06294158 id: LANYARD-ICU-1.1 briefTitle: Light and Noise: Objectively Assessing Environmental Risk Factors for Delirium in the ICU acronym: LANYARD-ICU overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-07 date: 2025-11 date: 2024-03-05 date: 2024-03-05 name: Medical University of Graz class: OTHER briefSummary: Recognition of delirium as a medical entity with relevance to both morbidity and mortality, especially in critically ill patients, is a relatively recent development. However, research into delirium prevention and treatment is now in focus of scientific efforts internationally.
This project is planned to be carried out as an observational pilot study at three perioperative ICUs at the University Medical Centre Graz. Adult patients shall be screened for inclusion, if not deeply sedated. Suitable patients shall be included into the study after written informed consent or deferred consent if they can be expected to remain in the ICU for at least another two days, if they are not already in delirium, if the ICU environment is not actively modified for therapeutic reasons and if no treatment limitations are in place. Over a study duration of one year, 250 to 300 patients are expected to be enrolled into the study. Of those, 60 to 120 patients are likely to develop delirium.
Baseline data known to be of relevance for outcome prediction in critically ill patients and factors known to predispose for development of delirium during ICU and hospital stay will be collected. Study equipment will be deployed to measure noise levels and illumination repeatedly over the day. Daily assessments for delirium using the Confusion Assessment Method in Intensive Care Units (CAM-ICU) will be performed. Vital status, physiologic parameters and parameters of ongoing treatment will concomitantly be documented on a daily basis.
Data on light and noise levels are then to be unified with parameters of physiology and treatment, vital status, and results of daily assessments for delirium. Statistical analysis using methods of descriptive and comparative statistics as well as both unadjusted and adjusted logistic regression analysis will be performed to identify factors significantly associated with the development of delirium (i.e., risk factors). conditions: Delirium conditions: Critical Illness studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 250 type: ESTIMATED name: Brightness measurement name: Sound level measurement measure: Delirium sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Medical Centre Graz, Dept. of Anaesthesiology and Intensive Care Medicine city: Graz state: Styria zip: 8036 country: Austria name: Andrea Berghofer, Mag role: CONTACT phone: +43 316 385 0 phoneExt: 84663 email: anaesthesie-allgemein@medunigraz.at name: Paul Zajic, MD PhD role: PRINCIPAL_INVESTIGATOR name: Philipp G. H. Metnitz, MD PhD role: SUB_INVESTIGATOR name: Andreas Münch, MD role: SUB_INVESTIGATOR name: Andreas Waltensdorfer, MD role: SUB_INVESTIGATOR name: Gabriel Honnef, MD PhD role: SUB_INVESTIGATOR name: Christian Regvar, MD role: SUB_INVESTIGATOR name: Barbara Hallmann, MD role: SUB_INVESTIGATOR name: Martin Rief, MD PhD role: SUB_INVESTIGATOR name: Alexander Pichler, MD role: SUB_INVESTIGATOR name: Michael Eichlseder, MD role: SUB_INVESTIGATOR lat: 47.06667 lon: 15.45 hasResults: False
nctId: NCT06294145 id: U24AG072699 type: NIH link: https://reporter.nih.gov/quickSearch/U24AG072699 briefTitle: Effects of a Wellbeing Intervention on Inflammation Through Reward and Threat Processes acronym: SAVOR overallStatus: RECRUITING date: 2024-02-07 date: 2025-01-31 date: 2025-01-31 date: 2024-03-05 date: 2024-03-05 name: University of California, Los Angeles class: OTHER name: Network for Emotional Wellbeing name: National Institutes of Health (NIH) briefSummary: This study aims to evaluate how savoring influences reward and threat processes and downstream inflammation. Savoring is designed to enhance positive affect, which may blunt stress responses and reduce downstream inflammation. The investigators aim to examine changes in the brain following the savoring intervention. The investigators are particularly interested in changes in brain activity that are correlated with changes in inflammation-related markers in the blood. In this single-armed pilot trial, the investigators will assess how savoring alters reactivity to rewarding and threatening experiences, and then examine related changes in downstream inflammation. The investigators intend to recruit 20 undergraduate students to complete a 7-week standardized savoring intervention. Participants will complete brain scans, daily diaries, questionnaires, a behavioral task, and blood collection at pre- and post-intervention assessments. conditions: Low Positive Affect studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: All 20 participants will be assigned to the same 7-week savoring intervention. primaryPurpose: BASIC_SCIENCE masking: NONE count: 20 type: ESTIMATED name: Savoring Intervention measure: Positive affect measure: Negative affect measure: Depression measure: Anxiety measure: Perceived stress measure: Psychological wellbeing measure: Emotions measure: Reward measure: Savoring strategies measure: Interoception measure: Inflammation measure: Sustained Attention measure: Neural Reward Activity measure: Neural Threat Activity measure: Daily diary sex: ALL minimumAge: 18 Years maximumAge: 22 Years stdAges: ADULT facility: University of California, Los Angeles status: RECRUITING city: Los Angeles state: California zip: 90095 country: United States name: Robin B Blades role: CONTACT phone: 510-520-5780 email: robinblades@gmail.com name: Julienne Bower, PhD role: CONTACT phone: 310-825-3004 email: jbower@g.ucla.edu name: Julienne Bower, PhD role: PRINCIPAL_INVESTIGATOR name: Chloe Boyle, PhD role: SUB_INVESTIGATOR name: Naomi Eisenberger, PhD role: SUB_INVESTIGATOR name: Steve Cole, PhD role: SUB_INVESTIGATOR name: Michelle Craske, PhD role: SUB_INVESTIGATOR name: Aileen Echiverri, PhD role: SUB_INVESTIGATOR name: Robin Blades role: SUB_INVESTIGATOR lat: 34.05223 lon: -118.24368 hasResults: False
nctId: NCT06294132 id: 4016601 briefTitle: Effect of Lumbar Manipulation on Intervertebral Motion, Pain, and Disability overallStatus: RECRUITING date: 2024-02-27 date: 2024-10-21 date: 2024-10-28 date: 2024-03-05 date: 2024-03-08 name: Ithaca College class: OTHER briefSummary: Background / Purpose:
There is an ongoing debate regarding the ability of physical therapists to manually sense intervertebral motion. Physical therapists use intervertebral hypomobility as a clinical indicator for spinal manipulation. Also in question is the mechanism of improvement observed after spinal manipulation. Some argue that the improvement is purely neurophysiologic and unrelated to changes in intervertebral motion. This study aimed to determine the diagnostic accuracy of a physical therapist's manual assessment of lumbar intervertebral motion compared to ultrasound imaging and the effect of lumbar manipulation on intervertebral motion, pain, and disability,