hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06354998 id: mRNA-1273-P401 briefTitle: A Study of an Investigational mRNA-1273.815 COVID-19 Vaccine in Previously Vaccinated Adults overallStatus: RECRUITING date: 2024-04-08 date: 2024-06-01 date: 2024-06-01 date: 2024-04-09 date: 2024-04-22 name: ModernaTX, Inc. class: INDUSTRY briefSummary: To evaluate immune responses of an Investigational mRNA-1273.815 vaccine against the Omicron subvariant strain (XBB.1.5) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). conditions: SARS-CoV-2 studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 200 type: ESTIMATED name: Investigational mRNA-1273.815 name: Licensed Spikevax Vaccine measure: Geometric Mean of Neutralizing Antibodies (nAbs) Against SARS-CoV-2-specific Strain at Day 15 measure: Number of Participants with Serious Adverse Events (SAEs), Adverse Events (AEs) of Special Interest (AESIs), and AEs Leading to Withdrawal From the Study measure: Seroresponse Rate of nAb Against the SARS-CoV-2-specific Strain at Day 15 measure: Geometric Mean Ratio of nAb Against the SARS-CoV-2-specific Strain for Investigational mRNA-1273.815 Over the Licensed Spikevax Vaccine at Day 15 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Paratus Canberra status: RECRUITING city: Canberra state: Australian Capital Territory zip: 2617 country: Australia lat: -35.28346 lon: 149.12807 facility: Holdsworth House status: RECRUITING city: Darlinghurst state: New South Wales zip: 2010 country: Australia lat: -33.87939 lon: 151.21925 facility: Paratus Brisbane status: RECRUITING city: Brisbane state: Queensland zip: 2617 country: Australia lat: -27.46794 lon: 153.02809 facility: USC Morayfield status: NOT_YET_RECRUITING city: Morayfield state: Queensland zip: 4506 country: Australia lat: -27.10876 lon: 152.94907 facility: University of the Sunshine Coast, South Bank status: RECRUITING city: South Brisbane state: Queensland zip: 4101 country: Australia lat: -27.48034 lon: 153.02049 facility: Emeritus Melbourne status: RECRUITING city: Camberwell state: Victoria zip: 3124 country: Australia lat: -37.84205 lon: 145.0694 facility: AusTrials Sunshine Hospital status: RECRUITING city: Melbourne state: Victoria zip: 3021 country: Australia lat: -37.814 lon: 144.96332 hasResults: False
nctId: NCT06354985 id: 23-5996 id: MODEX2023 type: OTHER domain: Clinical Trial Protocol Number id: FRN:183960 type: OTHER_GRANT domain: CIHR id: CTO Project ID: 4701 type: OTHER domain: Clinical Trials Ontario briefTitle: Modafinil and Exercise for Post Stroke Fatigue acronym: MODEX overallStatus: NOT_YET_RECRUITING date: 2024-10 date: 2027-09 date: 2027-09 date: 2024-04-09 date: 2024-04-09 name: University Health Network, Toronto class: OTHER briefSummary: A stroke happens when blood flow to the brain is stopped and the brain gets damaged. At least half of people with a stroke have fatigue months and even years later. A lot of people report fatigue as one of the worst symptoms post stroke that can affect daily activities and the length and quality of life. Though all the reasons for fatigue after stroke and how to best treat it are not fully understood, the investigators think that fatigue results from the stroke changing the brain, reducing physical fitness, and decreasing muscle strength. A stroke can also affect sleep and mood, which can impact how people feel too. It is also not known why women experience more fatigue than men after a stroke.
The investigators will assess the results to identify the best treatment for post stroke fatigue and hope to be able to find a treatment that will help reduce fatigue and improve quality of life after a stroke. conditions: Stroke conditions: Fatigue conditions: Modafinil conditions: Exercise studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: All members of the research team and the participants will be blinded to medication group allocation, but cannot be blinded to exercise group allocation. Evaluators and the study statistician will be blinded to the exercise group allocation. The study statistician and the rest of the Data Safety Monitoring Board will have access to the medication assignment if needed (e.g. adverse drug reaction). whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 224 type: ESTIMATED name: Modafinil 200mg name: Placebo name: Exercise Program One name: Exercise Program Two measure: Severity of Fatigue Symptoms measure: Severity of Fatigue Symptoms measure: Impact on Quality of Life measure: Walking Recovery measure: Leg Strength and Coordination measure: 3-Day Physical Activity Assessment measure: Mood and Anxiety measure: Attention measure: Cognition measure: Health Resource Utilization measure: Quality Adjusted Life Years sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06354972 id: SASP Turin briefTitle: Impact of SASP in the GCF on the Outcomes of Periodontal Regeneration overallStatus: COMPLETED date: 2022-01-02 date: 2022-11-02 date: 2024-01-02 date: 2024-04-09 date: 2024-04-09 name: University of Turin, Italy class: OTHER briefSummary: Objectives: To test the impact of clinical inflammation and molecular expression profile (senescence-associated secretory phenotype; SASP) in the gingival crevicular fluid (GCF) on the outcomes of minimally-invasive periodontal regeneration in intra-bony defects.
Methods: Sites associated with intrabony defects ≥ 3 mm requiring periodontal regeneration through minimally-invasive surgical technique were included. Pre-operatively, GCF was sampled for inflammatory biomarker analysis related to SASP \[interleukin (IL)-1β, IL-6 and IL-12; matrix-metalloproteinases (MMP)-8 and -9\]. Correlation analyses and logistic regression models were performed to assess the impact of predictors on clinical and radiographic outcomes. conditions: Periodontal Diseases studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 40 type: ACTUAL name: Minimally invasive surgical procedure measure: Clinical attachment level change measure: Achievement of composite outcome measure measure: Radiographic bone level change measure: Probing pocket depth change sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CIR Dental School city: Turin zip: 10126 country: Italy lat: 45.07049 lon: 7.68682 hasResults: False
nctId: NCT06354959 id: 1030020 briefTitle: Prehab for Lung and Esophageal Cancer overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-06-01 date: 2027-01-01 date: 2024-04-09 date: 2024-04-09 name: Nova Scotia Health Authority class: OTHER name: Dalhousie University briefSummary: Research indicates that individuals diagnosed with lung or esophageal cancer who enter treatment with higher functional capacities, improved body composition, and better nutrition status tend to experience better outcomes and a higher quality of life. The primary objective of a prehabilitation health coaching program is to enhance the overall health and well-being of patients before they undergo major surgery.This personalized 8-week program encompasses elements such as nutrition, smoking cessation, sleep hygiene, and movement, equipping participants with the knowledge and tools needed to adopt healthier lifestyles. conditions: Neoplasm of Lung conditions: Neoplasms conditions: Exercise conditions: Surgery studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 25 type: ESTIMATED name: Prehabilitation measure: Feasibility- Recruitment measure: Feasibility- Participant fidelity measure: Feasibility - Safety measure: Feasibility - Retention/Attrition measure: Feasibility - Participant Experience measure: Feasibility- Attendance measure: Functional Assessment of Cancer Therapy - Lung OR Esophageal (FACT-L/ FACT- E) measure: Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) measure: 5x chair stand measure: Stair climb test measure: Grip strength measure: Resting Heart rate measure: Resting blood pressure sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Victoria General Hospital city: Halifax state: Nova Scotia country: Canada name: Jodi Langley role: CONTACT email: jodi.langley@dal.ca lat: 44.64533 lon: -63.57239 hasResults: False
nctId: NCT06354946 id: SCORE 4C briefTitle: External Validation of Simplified 4C Mortality Score by Deleting CRP acronym: 4Cs overallStatus: COMPLETED date: 2020-01-01 date: 2022-11-30 date: 2022-12-30 date: 2024-04-09 date: 2024-04-09 name: University of Monastir class: OTHER briefSummary: The (Coronavirus Clinical Characterisation Consortoum) 4C mortality score is an accessible risk stratification score developed by the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) based on eight different parameters: age, sex, number of comorbidities, respiratory rate, peripheral oxygen saturation, level of consciousness (Glasgow Coma Scale), urea or blood urea nitrogen (BUN) level, and C reactive protein (CRP). It was derived and internally validated on a large, diverse cohort within the United Kingdom but requires external validity to confirm its generalizability. A recent validation study demonstrated that the score could be simplified by deleting CRP item which is favorable to its widespread use. we aim to validate a modified 4C score. conditions: COVID-19 Pandemic studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 1500 type: ACTUAL measure: The primary outcome was all-cause in-hospital mortality rate The primary outcome was all-cause in-hospital mortality rate measure: Number of patients admitted to the ICU sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: EPS Fattouma Bourguiba University hospital city: Monastir zip: 5020 country: Tunisia lat: 35.77799 lon: 10.82617 hasResults: False
nctId: NCT06354933 id: DemeNSS (3785) briefTitle: Neurological Soft Signs in Neurodegenerative Dementias acronym: DemeNSS overallStatus: COMPLETED date: 2022-04-01 date: 2023-11-30 date: 2024-02-01 date: 2024-04-09 date: 2024-04-15 name: University of Milano Bicocca class: OTHER briefSummary: The goal of this observational study is to investigate the prevalence of Neurological Soft Signs (NSS) in various categories of dementia patients compared to matched controls. The main questions it aims to answer are:
Researchers will compare dementia groups (Alzheimer's disease, Frontotemporal dementia, Corticobasal syndrome and Lewy body dementia) to controls to determine differences in NSS prevalence. Additionally, associations between NSS and neuropsychiatric symptoms, as well as cognitive performance, will be explored. conditions: Alzheimer Disease conditions: Dementia With Lewy Bodies conditions: Frontotemporal Dementia conditions: Corticobasal Degeneration studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 186 type: ACTUAL name: Neurological Soft Signs measure: Difference in NSS measure: Association between NSS and Neuropsychiatric Inventory (NPI) scores measure: Correlation between NSS scores and cognitive function assessed by Mini-Mental State Examination (MMSE) measure: Correlation between NSS scores and cognitive function assessed by Frontal Assessment Battery (FAB) measure: Longitudinal changes in NSS scores sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione IRCCS San Gerardo dei Tintori city: Monza state: Lombardia zip: 20900 country: Italy lat: 45.58005 lon: 9.27246 hasResults: False
nctId: NCT06354920 id: HUM00247781 id: R18HS028963 type: AHRQ link: https://reporter.nih.gov/quickSearch/R18HS028963 briefTitle: M-Well Bonding Bundle to Improve Patient-Physician Relationships overallStatus: RECRUITING date: 2024-04-08 date: 2026-06 date: 2026-06 date: 2024-04-09 date: 2024-04-10 name: University of Michigan class: OTHER name: Agency for Healthcare Research and Quality (AHRQ) briefSummary: The goal of this clinical trial is to learn more about the interaction between a patient in the hospital and their treating doctor. A good relationship between patients and their doctors can help improve patient care. Doctors will be asked to use strategies to improve their interactions with patients in the hospital. The main questions it aims to answer are:
2. Complete a brief survey after meeting with their doctor. conditions: Physician-Patient Relations studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Quasi-experimental randomized controlled trial primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 3624 type: ESTIMATED name: Bonding Bundle measure: Jefferson Scale of Empathy (JSE) measure: Jefferson Scale of Patient's Perceptions of Physician Empathy (JSPPPE) measure: Communication Assessment Tool measure: Frequency of use of intervention methods measure: Perceived duration of interaction measure: Wake Forest Physician Trust Scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Michigan status: RECRUITING city: Ann Arbor state: Michigan zip: 48109 country: United States name: Sanjay Saint, MD, MPH role: CONTACT phone: 734-615-8341 email: Saint@umich.edu name: Karen Fowler, MPH role: CONTACT phone: 734-845-3611 email: Karen.Fowler@va.gov name: Sanjay Saint, MD, MPH role: PRINCIPAL_INVESTIGATOR name: Christopher Smith, MD role: SUB_INVESTIGATOR lat: 42.27756 lon: -83.74088 facility: VA Ann Arbor Healthcare System status: NOT_YET_RECRUITING city: Ann Arbor state: Michigan zip: 48109 country: United States name: Nathan Houchens, MD role: CONTACT phone: 734-845-5922 email: nathanho@med.umich.edu name: Karen Fowler, MPH role: CONTACT phone: 734-845-3611 email: Karen.Fowler@va.gov name: Nathan Houchens, MD role: PRINCIPAL_INVESTIGATOR name: Sanjay Saint, MD, MPH role: SUB_INVESTIGATOR lat: 42.27756 lon: -83.74088 hasResults: False
nctId: NCT06354894 id: MACOXS id: 133/2020/U type: REGISTRY domain: MACOXS briefTitle: Percutaneous Pinning Versus Plate and Screws for Surgical Fixation of Proximal Humeral Fractures overallStatus: RECRUITING date: 2020-11-01 date: 2024-11-01 date: 2024-11-01 date: 2024-04-09 date: 2024-04-09 name: University of Turin, Italy class: OTHER briefSummary: The aim of this multicenter nonrandomised study is to prospectively compare the clinical and radiographic results of two different techniques of surgical fixation of proximal humeral fractures: percutaneous pinning versus plate and screws. conditions: Proximal Humeral Fractures studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 120 type: ESTIMATED name: Proximal humeral fracture fixation measure: Oxford Shoulder Score (OSS) measure: Quick Disabilities of the arm, shoulder and hand (DASH) score measure: Subjective Shoulder Value (SSV) measure: Radiographic outcomes sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: San Luigi Gonzaga Hospital status: RECRUITING city: Orbassano state: Turin zip: 10043 country: Italy name: Enrico Bellato, MD role: CONTACT phone: +393406429207 email: enrico.bellato@unito.it lat: 45.00547 lon: 7.53813 hasResults: False
nctId: NCT06354881 id: 0967 id: TM61008S3 type: OTHER_GRANT domain: British Heart Foundation briefTitle: The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke acronym: LACUNAR_CA overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-03 date: 2026-03 date: 2024-04-09 date: 2024-04-09 name: University of Leicester class: OTHER name: British Heart Foundation name: University Hospitals, Leicester briefSummary: The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke. Participants will be asked to undergo a simple brain blood flow assessment at their initial appointment, whereby they will be asked to sit and stand twice. The patients will then be asked for a follow-up assessment 4 weeks after, identical to the first. This will allow us to look at any changes in brain blood flow from before management of risk factors and 4 weeks after management of risk factors. conditions: Lacunar Stroke studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 75 type: ESTIMATED name: Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres measure: Cerebral blood velocity measurements before and after management of uncontrolled risk-factors in those diagnosed with lacunar stroke syndromes. measure: Arterial blood pressure measurements before and after management of uncontrolled risk-factors in those diagnosed with lacunar stroke syndromes. measure: Heart rate measurements before and after management of uncontrolled risk-factors in those diagnosed with lacunar stroke syndromes. measure: End-tidal carbon dioxide measurements before and after management of uncontrolled risk-factors in those diagnosed with lacunar stroke syndromes. measure: Compare cerebral haemodynamics in lacunar stroke patients with older patients experiencing advanced chronic cerebrovascular disease with lacunar stroke syndromes, whose risk-factors are already managed.(CA). measure: Compare cerebral haemodynamics in lacunar stroke patients with older patients experiencing advanced chronic cerebrovascular disease with lacunar stroke syndromes, whose risk-factors are already managed. (VMR). measure: Compare cerebral haemodynamics in lacunar stroke patients with older patients experiencing advanced chronic cerebrovascular disease with lacunar stroke syndromes, whose risk-factors are already managed.(ARI). sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospitals of Leicester NHS Trust city: Leicester state: Leicestershire zip: LE1 5WW country: United Kingdom name: Amit Mistri role: CONTACT email: amit.mistri@uhl-tr.nhs.uk lat: 52.6386 lon: -1.13169 hasResults: False
nctId: NCT06354868 id: NNBioEP004 briefTitle: A Study to Assess utiLity of BIoEP as an Early Prognostic Indicator for Predicting Anti-Seizure Medication (ASM) Efficacy acronym: ECLIPSE overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-12 date: 2027-06 date: 2024-04-09 date: 2024-04-12 name: Neuronostics Ltd class: INDUSTRY name: Cornwall Partnership NHS Foundation Trust briefSummary: This multisite prospective clinical study is to investigate the relationship between seizure type and frequency with the BioEP result during ASM titration in newly diagnosed patients with epilepsy, and to assess the utility of BioEP as an early prognostic indicator of ASM efficacy conditions: Epilepsy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 158 type: ESTIMATED measure: The relationship between BioEP and seizure frequency. measure: Association between the 12-month change from baseline in BioEP result and the patients reported global impression of change sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06354855 id: NEU-FTR-FE-04 briefTitle: "Which Type of Exercise is More Effective in Chronic Constipation? overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-15 date: 2024-10 date: 2024-12 date: 2024-04-09 date: 2024-04-09 name: Necmettin Erbakan University class: OTHER briefSummary: In this study, it will be investigated whether a daily 30-minute walk or abdominal breathing exercise is more effective on chronic constipation. conditions: Chronic Constipation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two groups with a conventional therapy control group primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The assignment of people to groups will be done by a statistician, apart from the research using a computer program. Randomization will be determined by entering the total number of cases through the program whose URL address is https://www.randomizer.org. whoMasked: OUTCOMES_ASSESSOR count: 54 type: ESTIMATED name: Group is doing breathing exercises while watching videos name: Medium pace walking group measure: Visual Analog Scale (VAS) measure: Constipation Severity Scale (CSS) measure: Chronic Constipation Quality of Life Scale sex: ALL minimumAge: 20 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Nezahat Keleşoğlu Health Sciences Necmettin Erbakan University city: Konya state: Meram zip: 42000 country: Turkey lat: 37.87135 lon: 32.48464 hasResults: False
nctId: NCT06354842 id: 12345678 briefTitle: Measurement of Sweat Sodium Concentration in Patients With Chronic Kidney Disease overallStatus: COMPLETED date: 2018-10-05 date: 2020-12-11 date: 2020-12-11 date: 2024-04-09 date: 2024-04-09 name: Medical University of Vienna class: OTHER briefSummary: It has been shown that excretion of sodium and water through the skin in the form of sweat represents a regulatory mechanism of electrolyte- and fluid balance. Since patients with chronic kidney disease (CKD) exhibit increased skin sodium content, we investigated the feasibility of sweat testing as a novel experimental tool to a more complete assessment of fluid- and sodium homeostasis.
Decline of kidney function showed a significant association with lower sweat rates: adj R²= 0.2278, F(2, 61) = 10.29, p = 0.000141. Sweat sodium concentrations were increased in moderate CKD, however this effect was lost in end stage renal disease: adj R² = 0.3701, F(4, 59) = 10.26, p = 2.261e-06. We observed higher sweat weight in males compared to females.
Diagnostic sweat analysis represents an innovative and promising noninvasive option for more thorough investigation of sodium- and fluid homeostasis in CKD patients. Lower sweat rates and higher sweat sodium concentrations represent a unique feature of CKD patients with potential therapeutic implications. conditions: Chronic Kidney Diseases studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 64 type: ACTUAL name: pilocarpine iontopheresis measure: Sweat sodium concentration sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Medical University of Vienna city: Vienna zip: 1090 country: Austria lat: 48.20849 lon: 16.37208 hasResults: False
nctId: NCT06354829 id: MEDICALBUM briefTitle: Medical Images Collection Research acronym: MEDICALBUM overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2049-04 date: 2049-04 date: 2024-04-09 date: 2024-04-09 name: Mario Negri Institute for Pharmacological Research class: OTHER name: Papa Giovanni XXIII Hospital briefSummary: This is a not-for-profit project for the collection, archiving and reuse of magnetic resonance imaging, computed tomography and ultrasound images, and related demographic and clinical data, for research purposes only. conditions: Kidney Diseases conditions: Brain Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 300 type: ESTIMATED name: Medical imaging procedures measure: Creation of a medical images collection sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clinical Research Center for Rare Disease Aldo e Cele Daccò city: Ranica state: BG zip: 24020 country: Italy name: Anna Caroli, PhD role: CONTACT phone: +3903545351 email: anna.caroli@marionegri.it lat: 45.72328 lon: 9.71335 hasResults: False