hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06260969 id: TJHH-2023-WM13 briefTitle: Endovascular Treatment of Acute Ischemic Stroke With Underlying Intracranial Artery Stenosis overallStatus: RECRUITING date: 2022-09-01 date: 2025-09-30 date: 2025-09-30 date: 2024-02-15 date: 2024-02-15 name: Tianjin Huanhu Hospital class: OTHER briefSummary: The study is a prospective multicentre registry study. Patients admitted to 10 stroke centres nationwide from September 2022 to September 2025 with acute ischaemic stroke due to large vessel occlusion considering underlying ICAS and treated with emergency endovascular thrombolysis were included for analysis. Patients who met the general inclusion criteria underwent thrombectomy and the necessary remedial treatment. conditions: Large Vessel Occlusion conditions: Intracranial Artery Occlusion With Cerebral Infarction conditions: Endovascular Treatments conditions: Acute Ischemic Stroke studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 470 type: ESTIMATED name: balloon dilatation measure: Proportion of patients achieving a clinical prognosis of mRS 0-2 at 90 days measure: Proportion of patients with a good prognosis early after treatment measure: Change in final cerebral infarct volume relative to baseline at 24 (-2/+12) hours postoperatively on CT/MR measure: Vascular recanalization sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tianjin Huanhu Hospital status: RECRUITING city: Tianjin state: Tianjin country: China name: Ming Wei role: CONTACT phone: 13502182903 email: drweiming@163.com lat: 39.14222 lon: 117.17667 hasResults: False
nctId: NCT06260956 id: U01-ROC-001 id: 1U01AI173032 type: NIH link: https://reporter.nih.gov/quickSearch/1U01AI173032 briefTitle: Expecting Mother's Study of Consumption or Avoidance of Peanut and Egg acronym: ESCAPE overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2026-09 date: 2029-09 date: 2024-02-15 date: 2024-02-15 name: University of Rochester class: OTHER name: National Institute of Allergy and Infectious Diseases (NIAID) briefSummary: Peanut allergy is the most common cause of fatal and near-fatal food-allergic reactions and egg allergy is among the two most common causes of food-induced anaphylaxis. The proposed research will explore the development of sensitization to these food(s) in infants based on maternal consumption or avoidance during pregnancy and breastfeeding. conditions: Allergy and Immunology conditions: Peanut and Nut Allergy conditions: Egg Allergy conditions: Food Allergy in Infants conditions: Food Allergy Peanut studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: National, parallel, two arm (one-to-one allocation), single blinded, randomized controlled trial. primaryPurpose: PREVENTION masking: TRIPLE maskingDescription: Due to the nature of the intervention, the subjects must know which arm they are assigned to, however, biostatistician and investigators will be blinded to study assignment. whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 400 type: ESTIMATED name: Avoidance name: Consumption measure: Egg sensitization measure: Peanut and egg specific IgG and IgG4 measure: Antibodies in maternal blood measure: Egg allergy measure: Antigen concentrations measure: Exploratory: Peanut sensitization measure: Exploratory: Symptoms measure: Exploratory: Peanut sensitization sex: FEMALE minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: University of Rochester city: Rochester state: New York zip: 14642 country: United States lat: 43.15478 lon: -77.61556 hasResults: False
nctId: NCT06260943 id: 20221220 id: NCI-2024-00566 type: REGISTRY domain: NCI Clinical Trials Reporting Program (CTRP) briefTitle: Targeted Navigation in Hepatocellular Carcinoma (HCC) overallStatus: NOT_YET_RECRUITING date: 2024-05-31 date: 2026-10-31 date: 2026-10-31 date: 2024-02-15 date: 2024-02-15 name: University of Miami class: OTHER name: The V Foundation briefSummary: The investigators are trying to learn more about the personal perceptions and experiences regarding the needs of patients with liver cancer to help improve the care of all patients. The investigators would like to know whether there are needs that patients have or are aware of, especially those needs that the investigators have not been able to address. The investigators aim to develop a program that helps participants and participant's families to navigate the process of being diagnosed with liver cancer and receiving treatment. conditions: Hepatocellular Carcinoma conditions: Cholangiocarcinoma conditions: Hepatobiliary Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 50 type: ESTIMATED name: Target Navigation Pilot Program measure: Number of Days to First Contact measure: Number of Hours for Each Contact measure: Number of Days to First Appointment measure: Number of Days to First Treatment measure: Number of Months of Total Navigation measure: Number of Participants that Die Within One Year measure: Proportion of Participants Enrolled in Clinical Research sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Miami city: Miami state: Florida zip: 33136 country: United States name: Gloria Figueroa role: CONTACT phone: 305-243-0779 email: gef44@med.miami.edu name: Patricia Jones, MD role: CONTACT phone: (305) 243-0779 email: pdjones@med.miami.edu name: Patricia Jones, MD role: PRINCIPAL_INVESTIGATOR lat: 25.77427 lon: -80.19366 hasResults: False
nctId: NCT06260930 id: Value of chest ultrasonography briefTitle: Value of Chest Ultrasonography in ILD Screening overallStatus: COMPLETED date: 2017-01 date: 2019-09 date: 2019-12 date: 2024-02-15 date: 2024-02-15 name: Aswan University class: OTHER briefSummary: The main aim of this study is to detect the value of transthoracic ultrasonography in the diagnosis and assessment of ILDs in correlation to chest X- ray, blood gases, pulmonary function test and echocardiography and to compare it with high resolution CT (HRCT) as a golden diagnostic investigation. conditions: Interstitial Lung Disease studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 80 type: ACTUAL measure: Sensitivity and specificity of the lung sonography for interstitial lung disease screening sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06260917 id: E2-23-4148 briefTitle: The Effect of Urinating Through the Zipper or by Pulling Down the Trousers on Uroflowmetry Parameters in LUTS overallStatus: COMPLETED date: 2023-11-01 date: 2023-12-31 date: 2023-12-31 date: 2024-02-15 date: 2024-02-15 name: Ankara City Hospital Bilkent class: OTHER briefSummary: There are many factors that affect uroflowmetry parameters. One of these is the urination position. Research has mostly focused on standing and sitting urination positions. However, those who prefer the standing position as a habit can urinate by opening the zipper or lowering the trousers. Although the effect of these two applications on uroflowmetry parameters in healthy men has been investigated in only one study, their effect on patients with lower urinary tract symptoms has not been examined. conditions: Benign Prostatic Hyperplasia conditions: Micturition Disorder conditions: Urinary Obstruction conditions: Urinary Tract Disease conditions: Urologic Diseases studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 80 type: ACTUAL name: position of urination measure: Qmax measure: PVR measure: Qave measure: Duration of voiding sex: MALE minimumAge: 45 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ankara Bilkent City Hospital city: Ankara country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06260904 id: AIIMS BBSR/PGThesis/23-24/112 briefTitle: Efficacy and Safety of add-on Apremilast Versus add-on Methotrexate in Patients With Oral Lichen Planus overallStatus: NOT_YET_RECRUITING date: 2024-02-26 date: 2025-01-31 date: 2025-05-31 date: 2024-02-15 date: 2024-02-15 name: All India Institute of Medical Sciences, Bhubaneswar class: OTHER briefSummary: Lichen planus is an inflammatory disorder of unknown aetiology affecting the stratified squamous epithelia, with an estimated global prevalence of 0.22 to 0.5 %. Oral mucosa (Oral Lichen Planus; OLP) is the most commonly affected region. Corticosteroids are the primary treatment of choice. A prolonged treatment with steroids is required for clinical improvement, which increases the chances of long-term adverse effects. So, there is a need for newer, effective treatment modalities, such as retinoids, methotrexate, Janus kinase inhibitors, PDE4 inhibitors, etc.
Of these, methotrexate is a dihydrofolate reductase inhibitor that inhibits the replication and function of T and B lymphocytes. It has shown a good response to OLP (around 83%) in a study by Lajevardi et al. and can be considered a treatment option in patients with moderate to severe OLP. Apremilast is a drug with a novel immunomodulatory mechanism of action. It inhibits phosphodiesterase type IV, which increases levels of cyclic adenosine monophosphate (cAMP), thus activating protein kinase A and inhibiting various inflammatory mediators. Based on a pilot study by Paul et al., apremilast is associated with clinical improvement in lichen planus.
Among the various treatment options, there is a lack of head-on trials. Methotrexate is an immunosuppressant with various systemic adverse effects and requires close monitoring. Whereas apremilast is a non-immunosuppressive drug with a better safety profile, it does not show such adverse effects. These drugs can be used as an add-on to low-dose steroids in view of reducing the adverse effects associated with steroid therapy. To the best of our knowledge, there is no randomized controlled trial comparing these two drugs to date. Hence, the present study has been planned to evaluate the safety and efficacy of methotrexate versus apremilast as an add-on to the standard steroid therapy in OLP patients. conditions: Oral Lichen Planus studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: randomized, add-on, active-controlled, open-label, parallel-design clinical trial primaryPurpose: TREATMENT masking: NONE count: 64 type: ESTIMATED name: Prednisolone name: Apremilast name: Methotrexate measure: Pain by Visual Analogue Scale (VAS) score measure: Severity by Physician global assessment of disease (PGA) score measure: Severity and pain by oral mucosal disease severity score measure: serum IL 6 level measure: Quality of life by using oral health-related quality of life score (ORAL HEALTH IMPACT PROFILE - 14 ) measure: Incidence of treatment-emergent adverse events of both test and control group sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: AIIMS Bhubaneswar city: Bhubaneswar state: Odisha zip: 751019 country: India name: Monalisa Jena, MD role: CONTACT phone: 09438884193 email: pharm_monalisa@aiimsbhubaneswar.edu.in name: Biswanath Behera, MD role: CONTACT phone: 07978351200 email: dermat_biswanath@aiimsbhubaneswar.edu.id name: Biswanath Behera role: SUB_INVESTIGATOR name: Madhusmita Sethy role: PRINCIPAL_INVESTIGATOR name: Mowdharani PS role: PRINCIPAL_INVESTIGATOR lat: 20.27241 lon: 85.83385 hasResults: False
nctId: NCT06260891 id: ZnSCD briefTitle: Zinc Supplementation in Sickle Cell Disease acronym: ZnSCD overallStatus: NOT_YET_RECRUITING date: 2025-04-01 date: 2026-09-30 date: 2026-09-30 date: 2024-02-15 date: 2024-03-13 name: University of California, San Francisco class: OTHER name: American Society Hematology, Research Collaborative name: Children's Hospital of Philadelphia name: Johns Hopkins University name: Baylor College of Medicine name: Children's National Research Institute name: Children's Hospital Medical Center, Cincinnati name: Newark Beth Israel Medical Center name: University of Pennsylvania briefSummary: The goal of this short term prospective Phase II study is to compare the effects of two alternate daily doses of zinc (25 and 40 mg/day) in 34 randomly assigned homozygous Sickle Cell Disease (SCD-SS) patients aged 15-35 years old. The main question it aims to answer is: Which biomarkers are most responsive to zinc supplementation, and what is the maximum tolerated zinc dose that induces the desired changes in biomarkers of bone turnover? Participants will be recruited from 7 American Society Hematology Research Collaborative SCD Centers. Eligible SCD subjects will be invited to participate in the 16-week study, involving 2 baseline blood draws 4 weeks apart, followed by a 12-week zinc intervention. The findings from this study will be used to determine the dosage of zinc to be used in a larger, future study on the long term impact of zinc supplementation on bone health in SCD-SS. conditions: Sickle Cell Disease studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a delayed start parallel design where all subjects will have a usual care period, 2 baseline samples 4 weeks apart, followed by a 12 week zinc intervention, with samples at 8 and 12 weeks. primaryPurpose: OTHER masking: QUADRUPLE maskingDescription: n/a the 2 zinc capsule dosages (25 and 40 mg) will be compounded to look identical whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 34 type: ESTIMATED name: 25 mg/day zinc name: 40 mg/day zinc measure: Biomarker of Bone Formation (PINP) measure: Biomarker of Bone Resorption (CTx) measure: Biomarker of Bone Formation (BSAP) measure: Biomarker of Bone Resorption (TRAP 5b) sex: ALL minimumAge: 15 Years maximumAge: 35 Years stdAges: CHILD stdAges: ADULT facility: UCSF Benioff Children's Hospital Oakland city: Oakland state: California zip: 94609 country: United States name: Ellen Fung, PhD role: CONTACT phone: 510-428-3885 phoneExt: 4939 email: ellen.fung@ucsf.edu name: Beth Anne Martin role: CONTACT email: beth.martin@ucsf.edu lat: 37.80437 lon: -122.2708 hasResults: False
nctId: NCT06260878 id: REB23-0625 briefTitle: Short-term Intravenous Fluids for Prevention of Post-ERCP Pancreatitis acronym: STRIPE overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2027-12-31 date: 2028-06-30 date: 2024-02-15 date: 2024-02-15 name: University of Calgary class: OTHER briefSummary: This study will explore the efficacies of several practical short-term (peri-procedural) intravenous fluid regimens in the prevention of post- endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). PEP is the most common serious ERCP-related adverse event (AE), occurring in 5-15% of patients, and associated with significant morbidity, mortality, and healthcare utilization. Given the current lack of data on effectiveness of short-term fluid regimens in PEP prevention to inform practice, the results of the proposed study have the strong potential to impact ERCP practices worldwide, whether positive or negative. conditions: Post-ERCP Acute Pancreatitis studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 505 type: ESTIMATED name: Intravenous Ringer's lactate measure: Serum amylase measure: Pancreatitis measure: Bleeding measure: Cholangitis measure: Cardiorespiratory adverse event measure: Serum lipase measure: Electrolytes measure: Creatinine measure: Brain natriuretic peptide sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06260865 id: E-ETH-01K-CI02 briefTitle: A Confirmatory Trial of Multidisciplinary Digital Therapeutics for Patellofemoral Pain Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2024-07-31 date: 2024-08-30 date: 2024-02-15 date: 2024-02-15 name: EverEx Inc. class: INDUSTRY briefSummary: This randomized controlled confirmatory study will be evaluating an mobile application, MORA Cure (ETH-01K), owned by EverEx, Inc., to examine safety and effectiveness in individuals with patellofemoral pain syndrome. conditions: Patellofemoral Pain Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Multicenter randomized controlled trial primaryPurpose: TREATMENT masking: NONE count: 216 type: ESTIMATED name: MORA Cure name: Treatment as Usual measure: Usual pain severity assessed by the Visual Analogue Scale (VAS) measure: Usual pain severity assessed by the Visual Analogue Scale (VAS) measure: Worst pain severity assessed by the Visual Analogue Scale (VAS) measure: Functional disability assessed by the Kujala Patellofemoral Scale measure: Health-related quality of life assessed by EuroQol five-dimensional (EQ-5D) measure: Assessment of mental health symptoms specific to depression as assessed by the Patient Health Questionnaire-9 (PHQ-9) measure: Assessment of catastrophic thinking measured by Pain Catastrophizing Scale (PCS) measure: Flexion and extension strength of knee measure: Treatment adherence sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Myongji Hospital city: Goyang-si state: Gyeonggi-do zip: 10475 country: Korea, Republic of lat: 37.65639 lon: 126.835 facility: Hanyang University Guri Hospital city: Guri-si state: Gyeonggi-do zip: 11923 country: Korea, Republic of lat: 37.5986 lon: 127.1394 facility: CHA Bundang Medical Center city: Seongnam-si state: Gyeonggi-do zip: 13496 country: Korea, Republic of lat: 37.43861 lon: 127.13778 facility: Inha University Hospital city: Junggu state: Incheon-si zip: 22332 country: Korea, Republic of lat: 37.69175 lon: 126.60024 facility: Chung-Ang University Hospital city: Dongjak state: Seoul zip: 06973 country: Korea, Republic of lat: 35.15713 lon: 126.8166 facility: Seoul Metropolitan Government-Seoul National University Boramae Medical Center city: Dongjak state: Seoul zip: 07061 country: Korea, Republic of lat: 35.15713 lon: 126.8166 facility: Kyung Hee University Hospital at Gangdong city: Gangdong state: Seoul zip: 05278 country: Korea, Republic of facility: The Catholic University of Korea Seoul St. Mary's Hospital city: Seocho state: Seoul zip: 06591 country: Korea, Republic of lat: 37.49056 lon: 127.02 facility: Seoul National University Bundang Hospital city: Gyeonggi-do zip: 13620 country: Korea, Republic of lat: 37.58944 lon: 126.76917 facility: Asan Medical Center city: Seoul zip: 05505 country: Korea, Republic of lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06260852 id: ES20/Th8/23-11-2023 briefTitle: Identification of Minimum Focal Points in Vision Curve Formation overallStatus: RECRUITING date: 2024-02-01 date: 2024-08 date: 2024-08 date: 2024-02-15 date: 2024-03-07 name: Democritus University of Thrace class: OTHER briefSummary: The primary objective of this study is to identify how many focal points and at which distances are necessary for reliable visual curve formation and area of the curve (AoC) calculation using mathematical models and comparing the results to measurements acquired from participants that underwent uncomplicated pseudophakic presbyopia surgery. conditions: Presbyopia conditions: Pseudophakia conditions: Cataract conditions: Refractive Errors studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 80 type: ESTIMATED name: Diagnostic Test: Visual Acuity Assessment measure: Visual curves interpolation measure: Area of the curve (AOC) assessment measure: Visual acuity assessment sex: ALL minimumAge: 40 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Ophthalmology, University Hospital of Alexandroupolis status: RECRUITING city: Alexandroupolis state: Evros zip: 68100 country: Greece name: Georgios Labiris, MD, PhD role: CONTACT phone: 00302551030405 email: labiris@usa.net lat: 40.84995 lon: 25.87644 hasResults: False
nctId: NCT06260839 id: KY20232442-F-1 briefTitle: the Effect of Minimally Invasive Technique Assisted by Magnetic Resonance Neurography overallStatus: RECRUITING date: 2024-02-16 date: 2024-12-01 date: 2024-12-31 date: 2024-02-15 date: 2024-02-26 name: He Xiang class: OTHER briefSummary: The goal of this clinical trial is to to compare the therapeutic effect of minimally invasive surgery guided by magnetic resonance neurography(MRN) compared with non-magnetic resonance assisted minimally invasive surgery in patients with moderate to severe gluteal muscle contracture(GMC). The main question it aims to answer are: magnetic resonance neurography can better help optimize the surgical path of minimally invasive surgery in the treatment of gluteal muscle contracture.
Participants will underwent preoperative magnetic resonance examination according to different groups, and then the experimental group designed individualized surgical approach and MRN-assisted minimally invasive release according to the imaging findings. In the control group, preoperative magnetic resonance examination was only used to assist in the diagnosis and evaluation of gluteal muscle contracture, and the magnetic resonance results were not used to assist in the design of surgical approach. In the control group, non-MRN-assisted minimally invasive release was performed. The researchers will compare the intraoperative surgery-related indicators and postoperative hip function scores and complications of patients in different groups to see if magnetic resonance-assisted surgery has a better postoperative effect. conditions: Orthopedic Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 44 type: ESTIMATED name: magnetic resonance neurography name: no magnetic resonance neurography measure: Hip joint outcome score(HOS) scale measure: Objective hip function scoring scale measure: Hip joint function of patients measure: Imaging data of patients with gluteal muscle contracture measure: Record the duration of the patient 's surgery measure: The record of the length of the surgical incision of the patient measure: Measurement of intraoperative blood loss measure: The first ambulation time after operation measure: postoperative pain score measure: Postoperative patients were satisfied with the appearance measure: The record of postoperative wound infection measure: The occurrence of postoperative wound fat liquefaction measure: Postoperative wound peripheral nerve vascular injury measure: Postoperative incision hematoma formation measure: Gluteal muscle contracture severity ZHAO 's classification measure: Demographic characteristics of patients sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Xijing Hospital, the Fourth Military Medical University status: RECRUITING city: Xian state: Shaanxi zip: 710032 country: China name: Xiang He, MS role: CONTACT phone: 8684771013 email: caruya@163.com name: Long Bi, Prof. role: CONTACT phone: 8684771013 email: bilong@fmmu.edu.cn name: Long Bi, Prof. role: PRINCIPAL_INVESTIGATOR lat: 34.25833 lon: 108.92861 hasResults: False