The patient population will consist of adults men and women at least 18 years to younger than 66 years of age, who meet eligibility criteria. conditions: Multiple Myeloma studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 103 type: ESTIMATED name: Teclistamab name: Talquetamab name: Lenalidomide name: Bortezomib name: Daratumumab name: Dexamethasone measure: Rate of sustained MRD negativity (NGS, 10^-5) measure: Rate of conversion from positive MRD to negative MRD (NGS, 10^-5) measure: Number of adverse events measure: Rate of sustained MRD negativity (NGS, 10^-6) measure: Rate of conversion from positive MRD to negative MRD (NGS, 10^-6). measure: Rate of conversion from positive MRD to negative MRD (NGS, 10^-5). measure: Number of the death measure: Number of responses measure: Number of progression-free survival measure: Percentage of duration of response measure: Percenatge of time to response measure: Percentage of value of biological prognostic factors influencing outcome and response. measure: Percentage of score of quality of life sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CH de la Côte Basque city: Bayonne zip: 64109 country: France lat: 43.48333 lon: -1.48333 facility: CHU Caen city: Caen zip: 14033 country: France lat: 49.18585 lon: -0.35912 facility: CHRU DIjon city: Dijon zip: 21000 country: France lat: 47.31667 lon: 5.01667 facility: Chd Vendee city: La Roche-sur-Yon zip: 85925 country: France lat: 46.66667 lon: -1.43333 facility: CHRU LILLE - Hôpital Claude Huriez city: Lille zip: 59037 country: France lat: 50.63297 lon: 3.05858 facility: CHU Limoges city: Limoges zip: 87000 country: France lat: 45.83153 lon: 1.25781 facility: CH Lyon Sud city: Lyon zip: 69495 country: France lat: 45.74848 lon: 4.84669 facility: IPC Marseille Institut Paoli Calmettes city: Marseille zip: 13009 country: France lat: 43.29551 lon: 5.38958 facility: CHU Montpellier city: Montpellier zip: 34295 country: France lat: 43.61092 lon: 3.87723 facility: CHU de Nantes city: Nantes zip: 44093 country: France lat: 47.21725 lon: -1.55336 facility: APHP Hôpital Saint Louis city: Paris zip: 75010 country: France lat: 48.85341 lon: 2.3488 facility: APHP Hôpital Saint-Antoine city: Paris zip: 75012 country: France lat: 48.85341 lon: 2.3488 facility: APHP Hôpital La Pitié Salpétrière city: Paris zip: 75013 country: France lat: 48.85341 lon: 2.3488 facility: CHU BORDEAUX - Hôpital du Haut Lévêque city: Pessac zip: 33604 country: France lat: 44.81011 lon: -0.64129 facility: CHU Poitiers city: Poitiers zip: 86000 country: France lat: 46.58333 lon: 0.33333 facility: CHRU Rennes - Hôpital de Pontchaillou city: Rennes zip: 35033 country: France lat: 48.11198 lon: -1.67429 facility: ICANS Institut de Cancérologie Strasbourg Europe city: Strasbourg zip: 67200 country: France lat: 48.58392 lon: 7.74553 facility: CHU Toulouse city: Toulouse zip: 31059 country: France lat: 43.60426 lon: 1.44367 facility: CHU Tours Hôpital Bretonneau city: Tours zip: 37044 country: France lat: 47.38333 lon: 0.68333 facility: CHRU Nancy - Hôpitaux de Brabois city: Vandœuvre-lès-Nancy zip: 54511 country: France lat: 48.65 lon: 6.18333 hasResults: False