hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06347471 id: SBS-2023-477 briefTitle: The Transmission of Artemisinin Resistant Parasites Before and After Conventional Artemisinin-combination Therapy acronym: SPARTAN overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-12 date: 2026-04 date: 2024-04-04 date: 2024-04-04 name: Infectious Diseases Research Collaboration, Uganda class: OTHER name: London School of Hygiene and Tropical Medicine name: Radboud University Medical Center briefSummary: A prospective study will be carried out in an area where parasites with reduced sensitivity to malaria drugs (artemisinins) have recently emerged. The study will recruit participants from patients who attend the clinic with uncomplicated malaria and are treated with conventional artemisinin-combination therapies (ACT) as part of standard clinical care. From this population, we will select P. falciparum gametocyte carriers.
The study population will consist of passively recruited patients with uncomplicated P. falciparum malaria who are microscopy positive for gametocytes. Participants will be treated with conventional therapies for uncomplicated malaria without randomization: artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DHA-PPQ). All doses are supervised. Parasite clearance is assessed ex vivo by ring-stage survival assays and by daily slides during the first days of treatment.
Gametocyte carriage and gametocyte commitment/production will be determined for resistant and wild type infections before, during and after treatment. In addition, venous blood will be collected at three timepoints to assess transmission to mosquitoes before (d0), during (d2) and after treatment (d7). The total duration of participation will be 7 days, the primary endpoint will be the reduction in mosquito infection rates at d2 (artemether-lumefantrine) or d7 (dihydroartemisinin-piperaquine) compared to pre-treatment. conditions: Falciparum; Malaria studyType: INTERVENTIONAL phases: PHASE4 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: Artemether-lumefantrine name: Dihydroartemisinin-Piperaquine measure: Mean within person percent change (presented as percent reduction) in mosquito infection rate in infectious individuals from baseline. measure: Mean within person percent change (presented as percent reduction) in mosquito infection rate from baseline measure: Mean oocyst intensity (in all/all infected mosquitoes) measure: Male and female gametocyte sex ratio (proportion male) measure: Gametocyte circulation time measure: Gametocyte area under the curve measure: Asexual parasite prevalence measure: Asexual parasite density measure: Total parasite prevalence measure: Total parasite density measure: The density of ΔPfK13 vs wild type genotypes measure: The density of ΔPfK13 vs wild type genotypes in oocysts and sporozoites in mosquitoes that become infected before and after initiation of treatment sex: ALL minimumAge: 2 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Dr. Ambrosoli Memorial Hospital city: Kalongo state: Agago District country: Uganda name: Maurice Akao, MBChB role: CONTACT facility: Patongo Health Facility IV city: Patongo state: Agago District country: Uganda name: MD role: CONTACT lat: 2.74472 lon: 33.32417 hasResults: False
nctId: NCT06347458 id: BG-CA-23-001 briefTitle: BG1805 Injection in the Treatment of Relapsed or Refractory Acute Myeloid Leukemia in Children overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2027-08 date: 2024-04-04 date: 2024-04-04 name: Guangzhou Bio-gene Technology Co., Ltd class: INDUSTRY briefSummary: This is a single-arm, single-dose dose-escalation and dose-expansion study. conditions: Leukemia conditions: Acute Myeloid Leukemia studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 24 type: ESTIMATED name: BG1805 measure: 1.Dose Limited Toxicity Rate measure: 2.Incidence of Treatment-Emergent Adverse Events measure: 3.Concentration of CAR-T cells after Infusion (PK) measure: 4.overall response rate, ORR measure: 5.Concentration of Cytokine after Infusion (PD) sex: ALL minimumAge: 3 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06347445 id: GSM012024 briefTitle: Turkish Nationwide SurvEy of Glycemic and Other Metabolic Parameters of Patients With Diabetes Mellitus-2 (TEMD-2 Study) acronym: TEMD-2 overallStatus: COMPLETED date: 2022-10-01 date: 2023-01-30 date: 2023-01-30 date: 2024-04-04 date: 2024-04-04 name: Gulhane School of Medicine class: OTHER briefSummary: This study evaluates the metabolic control status, cardiovascular risk and frequency of comorbidities in diabetic patients followed in tertiary treatment centers in Turkey. conditions: Diabetes Mellitus studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 5707 type: ACTUAL name: There is no intervention. measure: Glycemia control status of Turkish adult patients with diabetes mellitus measure: Blood pressure control status of Turkish adult patients with diabetes mellitus measure: Lipid control status of Turkish adult patients with diabetes mellitus. measure: Weight control status of Turkish adult patients with diabetes mellitus. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Gulhane School of Medicine Department of Endocrinology and Metabolism city: Ankara zip: 06010 country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06347432 id: 24-119-H briefTitle: Em-power: Maximizing Functional Independence for Children With Severe Cerebral Palsy overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2027-03 date: 2027-03 date: 2024-04-04 date: 2024-04-04 name: Grand Valley State University class: OTHER briefSummary: For children with severe cerebral palsy, a powered wheelchair (PWC) may provide their only option for functional mobility and independence. PWC use is often restricted to a small percentage of children who can quickly demonstrate proficient PWC skills within a single 30-minute PWC trial. This 2-arm, parallel group, single blinded, pre-test-post-test randomized controlled trial will test our hypothesis that an 8-week PWC skills training intervention will produce greater improvements in children's PWC skills capacity immediately after the intervention and at an 8-week follow-up assessment. conditions: Cerebral Palsy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 16 type: ESTIMATED name: Power wheelchair skills training using the IndieTrainer system measure: Change in understanding how to use a power wheelchair measure: Change in power wheelchair skill performance measure: Change in parental/caregiver perceptions of changes in their children's performance of power wheelchair skill performance measure: Change in children's perceptions of changes in their performance of power wheelchair skill performance sex: ALL minimumAge: 5 Years maximumAge: 17 Years stdAges: CHILD facility: Grand Valley State University city: Grand Rapids state: Michigan zip: 49503 country: United States lat: 42.96336 lon: -85.66809 hasResults: False
nctId: NCT06347419 id: Iayas8 briefTitle: Body Awareness and Spinal Stability in Scoliosis overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2024-06-30 date: 2024-07-30 date: 2024-04-04 date: 2024-04-04 name: Gazi University class: OTHER briefSummary: Thirty volunteer patients diagnosed with scoliosis by a specialist physician at Gazi University Hospital Orthopedics and Traumatology Department and subsequently referred to Gazi University Physiotherapy and Rehabilitation Department for exercise training will be included in the study. The lumbar Pressure Measurement Test with Stabilizer and Rotation Stability Tests will be utilized to evaluate the spinal stability of the patients. Body awareness will be assessed using the Body Awareness Survey, comprising 18 questions. All assessments will be conducted at the Orthopedic Rehabilitation Clinic within the relevant department.
The results obtained from this study will elucidate the relationship between body awareness and spinal stability in individuals with scoliosis. conditions: Scoliosis Idiopathic studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 30 type: ESTIMATED name: Physiotherapy evaluation measure: Spinal stability measure: Rotary Stability measure: Body Awareness sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Gazi University Hospital city: Ankara zip: 06500 country: Turkey name: İnci H Ayas role: CONTACT phone: 0 312 216 26 21 email: inciayass@gmail.com lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06347406 id: FSKesihatan briefTitle: Effects of Combined Physiotherapy Management and Education overallStatus: RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-04-01 date: 2024-04-04 date: 2024-04-04 name: Fakulti Sains Kesihatan class: OTHER briefSummary: This observational study aims to determine the effects of combined physiotherapy programs and education in patellofemoral pain syndrome. The main questions it aims to answer are:
* Patient education Researcher will compare Blood flow exercises combined with physiotherapy exercises and education (Group A) with Physiotherapy exercises (Group B) to see if there is an effect on i) Pain ii) Muscle Functions (strength, muscle bulk, flexibility iii) Functional performance (anteromedial lunge, step-down, bilateral squat, balance, and reach) iv) Kinesiophobia v) Quality of life conditions: Patellofemoral Pain Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 128 type: ESTIMATED name: Blood flow restriction combined with physiotherapy and education measure: Numerical Pain Rating measure: The Knee injury and Osteoarthritis Outcome Score for patellofemoral pain and osteoarthritis (KOOS-PF) measure: Tampa Scale measure: Hand held dynamometer (HDD) measure: Knee Muscle performance Test with Dartfish software measure: Real time ultrasounds sex: ALL minimumAge: 18 Years maximumAge: 59 Years stdAges: ADULT facility: Fakulti Sains Kesihatan status: RECRUITING city: Shah Alam state: Selangor Darul Ehsan zip: 42300 country: Malaysia name: Zarina Zahari role: CONTACT phone: 0132094170 email: zarinazahari@uitm.edu.my name: Nurul Atiqah Mohamed Mosbi role: CONTACT phone: 603-3258 4300 email: atiqahmosbi@uitm.edu.my lat: 3.08507 lon: 101.53281 hasResults: False
nctId: NCT06347393 id: 6425 briefTitle: Transgender and Gender Diverse Individuals Screening for Breast Cancer acronym: GENESIS overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-03-31 date: 2026-03-31 date: 2024-04-04 date: 2024-04-24 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER name: Istituto Europeo di Oncologia name: Luigi Sacco University Hospital name: Fatebenefratelli Hospital name: Ospedale Policlinico San Martino name: Università degli studi di Messina, Messina name: IRCCS Azienda Ospedaliero-Universitaria di Bologna name: Arcispedale Santa Maria Nuova-IRCCS name: Federico II University name: Azienda Ospedaliero-Universitaria Careggi briefSummary: The goal of this multicentric prospective study is to evaluate the incidence of Breast Cancer in transgender and gender-diverse population. conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 1600 type: ESTIMATED name: Mammography and Breast Ultrasound measure: Incidence of Breast Cancer measure: The adherence rate to the screening sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06347380 id: CIP011 briefTitle: Usability Study of the FemPulse System overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-08-30 date: 2024-08-30 date: 2024-04-04 date: 2024-04-04 name: FemPulse Corporation class: INDUSTRY briefSummary: The objective of the study is to demonstrate that the FemPulse System can be used as indicated in the Instructions for Use (IFU), as applicable. conditions: Overactive Bladder studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: FemPulse System measure: Patient Satisfaction sex: FEMALE minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06347367 id: EU-FTR-GK-01 briefTitle: Short-term Effect of Exercise and Self-manual Approaches to Bloating - Distention overallStatus: RECRUITING date: 2023-01-01 date: 2024-04-17 date: 2024-04-19 date: 2024-04-04 date: 2024-04-04 name: Ege University class: OTHER briefSummary: Abdominal bloating and distension (ABD) are the most commonly gastrointestinal symptoms reported by patients with various functional gut disorders such as functional dyspepsia, irritable bowel syndrome and it is frequently associated with constipation. The pathophysiology of ABD is complex, often multifactorial and poorly understood. The reseach was hypothesised that short-term self-manual approaches and exercise for core muscles would have a positive effect on the symptoms of ABD. conditions: Gastrointestinal System Disease conditions: Functional Bloating conditions: Distension; Bowel conditions: Gastrointestinal Motility Disorder conditions: Pelvic Floor Dyssynergia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants will be assigned to Group 1 (exercise and self-manual approaches targeting only the diaphragm muscles) and Group 2 (exercise and self-manual approaches targeting both diaphragm and core muscles). primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: Triple (Participant, Investigator and Outcomes Assessor) whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: Group 1 (exercise and self-manual approaches targeting only the diaphragm muscles) name: Group 2 (exercise and self-manual approaches targeting both diaphragm and core muscles) measure: Abdominal bloating and distention (ABD) Perception of sensations measure: Superficial Electromyography (EMG) measure: Gastrointestinal Symptom Rating Scale (GSRS) measure: High-resolution anorectal manometry (HRAM) measure: Balloon Expulsion Test (BET) measure: Colon Transit Time (CTT) measure: Ultrasonography (USG) measure: Digital dynamometer sex: FEMALE minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ege University Faculty of Medicine, Department of Gastroenterology status: RECRUITING city: İzmir state: Bornova zip: 35100 country: Turkey name: Gülruh KARABAĞLI role: CONTACT phone: +90 5326612245 email: gulruhazad@gmail.com lat: 38.41273 lon: 27.13838 hasResults: False
nctId: NCT06347341 id: 2019-A02014-53 briefTitle: GlutN : Randomized, Double-blind, Crossover Clinical Trial to Confirm the Role of Gluten in Non-celiac Gluten Sensitivity acronym: GLUTN overallStatus: TERMINATED date: 2021-10-27 date: 2023-03-24 date: 2023-03-24 date: 2024-04-04 date: 2024-04-04 name: University Hospital, Clermont-Ferrand class: OTHER name: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement name: UCA (UFR de Médecine et UFR Pharmacie) briefSummary: For 25 years, non-celiac gluten sensitivity (NCGS) has been the subject of very prolific and confusing scientific literature. This clinical entity is defined by the appearance of digestive and extradigestive symptoms in the hours/days following the consumption of foods containing gluten, in the absence of celiac disease (CD) and wheat allergy (WA). The physiopathological mechanisms, neither allergic or autoimmune, remain poorly defined and no The main objective of the study was to demonstrate the role of gluten in triggering digestive symptoms and extradigestive products from the NCGS. The secondary objectives were to identify the pathophysiological mechanisms and diagnostic marker(s).usable diagnostic marker in the clinic has not yet been identified. conditions: The Objective is to Confirm the Role of Gluten in Triggering the Digestive and Extradigestive Symptoms of NCGS studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Prospective, crossover, randomized, double-blind clinical study comparing a gluten-containing diet to a gluten-free diet. primaryPurpose: DIAGNOSTIC masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 20 type: ACTUAL name: Clinical study comparing a gluten-containing diet to a gluten-free diet measure: The main objective of the study is to confirm the role of gluten in triggering the digestive and extradigestive symptoms of NCGS. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chu Estaing city: Clermont-Ferrand zip: 63100 country: France lat: 45.77966 lon: 3.08628 hasResults: False
nctId: NCT06347328 id: 23-AOI-01 briefTitle: The Benefits of Posterior Joint Infiltration in Chronic Low Back Pain acronym: InCHO overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2027-01 date: 2027-03 date: 2024-04-04 date: 2024-04-05 name: Centre Hospitalier Universitaire de Nice class: OTHER briefSummary: Lumbar facet joints have been implicated in chronic low back pain in over 45% of patients with isolated chronic common low back pain.
Facet joints have long been recognised as a source of back pain. In 1911, Goldthwait first recognised their role as a potential source of back pain. In 1933, Ghormley introduced the term "facet syndrome", defining lumbosacral pain with or without radicular pain. Badgley later suggested that facet joints could be a primary source of pain independently of spinal nerve compression. They demonstrated the role of posterior facet joints (PFJs) in a large number of patients with low back pain whose symptoms were not caused by a herniated disc. The underlying physiological concept of the PJF was introduced by Hirsch et al in 1963. They demonstrated that injecting a hypertonic saline solution into the region of the facet joints caused pain.
The management of chronic low back pain due to zygapophyseal involvement (lumbar facet joints) consists primarily of conservative treatment. This is based on analgesics, anti-inflammatory drugs, physiotherapy and weight loss, where appropriate. Other non-surgical options may be proposed, including glucocorticoid injections into the facet joints. Glucocorticoid injections, which act by reducing inflammation, are commonly used in routine care to treat spinal pain. This pain may be due to a variety of pathologies, including discogenic or facet-related, or mixed, ligamentous or muscular, linked to a regional or global disorder of spinal statics. They are commonly used as a standard treatment for chronic spinal pain.
In order to improve the clinical efficacy of the various interventional therapeutic solutions, some authors have supported the use of ultrasound guidance. Several studies have been published comparing ultrasound-guided infiltration and infiltration using anatomical location in the shoulder region, the iliopsoas and in epicondilitis. While ultrasound guidance in areas such as the iliopsoas or the shoulder seems useful, it has not yet been proven that guidance is advantageous in spinal areas, such as the facet joints.
The aim of our study is to show that ultrasound-guided zygoapophyseal infiltration is superior to anatomically-guided infiltration in terms of pain assessment. conditions: Chronic Low-back Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 102 type: ESTIMATED name: echo-guided infiltration name: non-echo-guided infiltration measure: Change of pain progression measure: measure function state by EIFEL questionnaire measure: measure function state by ODI questionnaire measure: pain evaluation by VAS scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU de NICE city: Nice state: CHU De Nice zip: 06000 country: France name: STEPHANIE FERRERO, MD role: CONTACT phone: +33492035477 email: ferrero.s@chu-nice.fr name: CHRISTIAN ROUX, Pr role: CONTACT email: roux.c2@chu-nice.fr name: STEPHANIE FERRERO, MD role: PRINCIPAL_INVESTIGATOR name: CHRISTIAN ROUX, Pr role: SUB_INVESTIGATOR lat: 43.70313 lon: 7.26608 facility: Ch Cannes city: Cannes country: France name: JOHANNA AZYLAY, MD role: CONTACT email: J.AZULAY@ch-cannes.fr lat: 43.55135 lon: 7.01275 hasResults: False
nctId: NCT06347315 id: 2302.CLI briefTitle: Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI) overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2027-12-15 date: 2027-12-15 date: 2024-04-04 date: 2024-04-29 name: Société des Produits Nestlé (SPN) class: INDUSTRY briefSummary: Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI) conditions: Mild Cognitive Impairment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: parallel and pivotal primaryPurpose: OTHER masking: TRIPLE maskingDescription: Randomized whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 380 type: ESTIMATED name: BrainXpert name: Placebo measure: Preclinical Alzheimer's Cognitive Composite (PACC) score measure: Preclinical Alzheimer's Cognitive Composite (PACC) (components effects) measure: Montreal Cognitive Assessment (MoCA) score measure: Preclinical Alzheimer's Cognitive Composite (PACC) accelerated decline measure: Wechsler Memory Scale - Fourth Edition (WMS-IV) Logical Memory IIb Delayed Recall Score accelerated decline measure: Mini-Mental State Examination (MMSE) score accelerated decline measure: Emergent Adverse Events (Safety and tolerability) sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06347302 id: EID 2023 briefTitle: Study of Vitreoretinal Molecular Changes During Rhegmatogenous Retinal Detachment acronym: LIPIDRET overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-10 date: 2025-10 date: 2024-04-04 date: 2024-04-04 name: Centre Hospitalier Universitaire Dijon class: OTHER briefSummary: Retinal detachment is a condition with an estimated incidence of between 9.5 and 18.2 cases per 100,000 individuals.
We therefore wish to demonstrate that the protein and PUFA contents of the vitreous humour are different between eyes with retinal detachment and eyes not affected by retinal detachment after macular surgery (epiretinal membrane or macular hole). We would like to show that the vitreous PUFA content is lower in the macular surgery group due to the absence of photoreceptor apoptosis and the absence of dehiscence causing communication between the subretinal space (photoreceptors whose membranes are very rich in PUFAs) and the vitreous space. We also hope to identify changes in the protein composition of vitreous fluid in patients with retinal detachment, with overexpression of proteins involved in inflammation pathways.
To do this, we will analyse intraoperative samples of vitreous humour, sub-retinal fluid and retinal fluid from patients undergoing vitrectomy for retinal detachment in the Ophthalmology Department of the Dijon University Hospital. A group of control patients will consist of patients operated on by vitrectomy for macular surgery (epiretinal membrane or macular hole) for whom a vitreous humour sample will also be taken.