hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06313385 id: 22-10-1180 briefTitle: Investigating the Impact of Indocyanine Green Titration on Fluorescent Intensity in Free Flap : An Exploration of Alternative Indicators overallStatus: ACTIVE_NOT_RECRUITING date: 2023-01-01 date: 2024-03-29 date: 2024-03-29 date: 2024-03-15 date: 2024-03-15 name: Indonesia University class: OTHER briefSummary: This study is a randomized clinical trials that aim to determine the effect of Indocyanine Green (ICG) titration dose on the intensity degree of ICG fluorescence imaging results. In addition, this study will also determine the relationship of other indicators such as flap surface temperature, transcutaneous pressure of carbon dioxide (TcPCO2), transcutaneous pressure of oxygen (TcPCO2), HIF - 1 alpha expression, and flap histopathology morphology to the intensity degree of ICG fluorescence imaging results with titrated doses. conditions: Free Flap conditions: Indocyanine Green conditions: Microsurgery conditions: Temperature Change, Body studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: The population were divided into three equal groups of indocyanine green concentration : 5 milligram per milliliter (mg/mL), 2,5 mg/mL, and 0,5 mg/mL primaryPurpose: DIAGNOSTIC masking: QUADRUPLE maskingDescription: The participants didn't know about indocyanine green (ICG) drug groups as well as the concentration that they received. The ICG was added into the syringe by research assistant without any label near the end of operation time. The ICG injection to the patient was performed by anesthesiologist who didn't know about the concentration at all. Outcome assessor didn't know about the given concentration. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 63 type: ESTIMATED name: Indocyanine Green Fluorescence (ICG) name: Temperature name: Transcutaneous oxygen and carbon dioxide pressure name: Histopathology name: Hypoxia inducible factor-1 (HIF-1) alpha measure: The Effect of Indocyanine Green Fluorescence Intensity to evaluate free flap perfusion measure: The ICG fluorescence intensity in different titration dose with flap surface Temperature measure: Correlation between ICG fluorescence intensity in different titration dose with transcutaneous carbon dioxide and oxygen pressure measure: Correlation between ICG fluorescence intensity concentration in different titration dose with flap neutrophile count measure: Correlation between ICG fluorescence intensity concentration in different titration dose with flap necrosis volume measure: Correlation between ICG fluorescence intensity concentration in different titration dose with vascular flap proliferation of the tissue measure: Correlation between ICG fluorescence intensity in different titration dose with HIF-1 Alpha sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia city: Jakarta Pusat state: Jakarta zip: 10430 country: Indonesia lat: -6.1818 lon: 106.8223 hasResults: False
nctId: NCT06313372 id: CA2085 briefTitle: Interpreting Respiratory Oscillometry in Adult Asthma and COPD: a Delphi Study overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-11 date: 2025-01 date: 2024-03-15 date: 2024-03-18 name: Scius Healthcare Solutions Pty Ltd class: INDUSTRY name: Chiesi Australia briefSummary: This is an international Delphi study to consolidate expert consensus on the use of respiratory oscillometry in the management of adult patients with asthma or chronic obstructive pulmonary disease (COPD).
Questions and statements will be repeated in subsequent rounds until the predefined level of consensus is met or the maximum number of rounds is achieved (limited to a maximum of 3 rounds). Aggregated results for each statement or question, including distribution of results and consensus status, will be provided to participants after each round to facilitate informed decisions in subsequent rounds. conditions: Asthma conditions: Chronic Obstructive Pulmonary Disease studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: OTHER count: 50 type: ESTIMATED name: Respiratory oscillometry measure: Identification of which respiratory oscillometry parameters (resistance, [R5, R20, R5-R20], reactance [X5, delta X5] or reactance area [AX]) are used to guide clinical management of asthma or COPD as determined by expert consensus using a ranking scale. measure: Identification of cut-off values used for respiratory oscillometry parameters (R5, X5, AX, R5-R20) to define an abnormal test result as determined by expert consensus using a 6-point categorical scale (Agree strongly to Disagree strongly) measure: Identification of cut-off values used for respiratory oscillometry parameters (R5, X5, and AX) to define a bronchodilator response as determined by expert consensus using a 6-point categorical scale (Agree strongly to Disagree strongly) measure: Identification of cut-off values used for oscillometry parameters (R5, X5, AX, R5-R20) to define a significant clinical change between visits as determined by expert consensus using a 6-point categorical scale (Agree strongly to Disagree strongly) sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06313359 id: FY2024-125 briefTitle: Fall Risk and Quality of Life: in Individuals With Cancer Treatment Related Peripheral Neuropathy. overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2025-03-30 date: 2025-06 date: 2024-03-15 date: 2024-03-15 name: Texas Woman's University class: OTHER briefSummary: The purpose of this research is to examine the impact of peripheral neuropathy on fall risk and quality of life in people who had cancer. Specifically, we are interested to find out if you have any difficulty with thinking, feeling, balancing, or moving around that will contribute to risk for falls or quality of life. We are also interested to see if you have any difficulty with doing two activities at the same time, such as walking and texting. conditions: Peripheral Neuropathy Due to Chemotherapy studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 40 type: ESTIMATED measure: Fall risk measure: Quality of life- in cancer patients measure: Trail Making Test (TMT) Parts A & B measure: Single Task- Working Memory measure: Single Task- Visual Attention Cognitive Task measure: Protective Sensation measure: Grip Strength measure: LE strength assessment- HHD measure: Dynamic Balance measure: Single Task- Gait Speed measure: Dual Task- Working Memory & Gait Speed - Composite measure measure: Dual Task- Visual Attention Cognitive Task & Gait Speed - Composite measure sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06313346 id: 2023.200 briefTitle: Effect of a Probiotic on Microbiota Associated With the Immune System and Inflammation. acronym: FLORABIOTIC overallStatus: RECRUITING date: 2024-01-08 date: 2024-04-30 date: 2024-06-15 date: 2024-03-15 date: 2024-03-15 name: Clinica Universidad de Navarra, Universidad de Navarra class: OTHER briefSummary: The goal of this randomized clinical trial is to learn about the effect of consuming a probiotic on the microbiota associated with immune health and inflammation in healthy women and men after 6 weeks of intervention.
* Placebo group (n=30): daily consumption of one placebo capsule. conditions: Probiotic conditions: Microbiota studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomised, double blinded, parallel intervention primaryPurpose: PREVENTION masking: QUADRUPLE maskingDescription: The products (experimental and placebo), will be produced by an external producer, who will save the codes. None of the researchers involved in the study development or analyses will know the association until the end of the study. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Probiotic name: Placebo measure: Fecal microbiota measure: Salivary cortisol measure: Body weight measure: Height measure: Body mass index measure: Body fat percentage measure: Body muscle mass measure: Body lean mass measure: Body water mass measure: Body bone mass measure: The incidence of catarrhal episodes measure: The gravity of catarrhal episodes measure: Gastrointestinal symptoms measure: Dietary intake measure: Physical activity measure: Adherence to capsule consumption sex: ALL minimumAge: 40 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre for Nutrition Research status: RECRUITING city: Pamplona state: Navarre zip: 31008 country: Spain name: Fermin Milagro, PhD role: CONTACT phone: 948425600 phoneExt: 806553 email: fmilagro@unav.es lat: 42.81687 lon: -1.64323 hasResults: False
nctId: NCT06313333 id: SID01 briefTitle: National Register of Moderate and Severe Adult Atopic Dermatitis acronym: ATOPYREG overallStatus: RECRUITING date: 2020-06-15 date: 2024-12-31 date: 2030-06-15 date: 2024-03-15 date: 2024-03-15 name: Societa Italiana di Dermatologia Medica, Chirurgica, Estetica e di Malattie Sessualmente Trasmesse class: OTHER briefSummary: Collect clinical history and treatment data of AD in adulthood; conditions: Atopic Dermatitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1500 type: ESTIMATED measure: Epidemiological data measure: Identification of factors for specific treatment measure: clinical and therapeutic data measure: characterization of diagnostic criteria measure: Assessment of possible conditioning factors sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ASST Spedali Civili di Brescia status: RECRUITING city: Brescia zip: 25123 country: Italy name: Piergiacomo MD Calzavara Pinton role: CONTACT phone: 0303995305 email: piergiacomo.calzavarapinton@unibs.it lat: 45.53558 lon: 10.21472 hasResults: False
nctId: NCT06313320 id: OAIC1344-23 briefTitle: Intraoperative Electroencephalographic Biomarkers of Postoperative Pain overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-03 date: 2026-06 date: 2024-03-15 date: 2024-03-15 name: University of Chile class: OTHER briefSummary: The goal of this study is to explore whether specific intraoperative EEG signals (brain waves or neuronal electrical activity) are associated with the severity of acute postoperative pain. conditions: Pain Postoperative conditions: Nociceptive Pain studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 80 type: ESTIMATED measure: Maximum Pain in PACU measure: Opioid Consumption in PACU measure: Maximum Pain at 24h measure: Presence of surgical related pain at day 7 measure: Presence of surgical related pain at day 30 sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Hospital Clinico de la Universidad de Chile city: Santiago state: RM zip: 7563215 country: Chile name: Rodrigo Gutierrez, MD, PhD role: CONTACT phone: +56995993665 email: rodrgutierrez@uchile.cl lat: -33.45694 lon: -70.64827 facility: Centro de Investigacion Clinica Avanzada city: Santiago country: Chile lat: -33.45694 lon: -70.64827 hasResults: False
nctId: NCT06313307 id: famotidine and melasma briefTitle: The Efficacy in Treatment of Facial Melasma Combined With Thulium 1927-nm Fractional Laser and Topical H2R Antagonist overallStatus: COMPLETED date: 2023-04-01 date: 2023-11-25 date: 2023-11-25 date: 2024-03-15 date: 2024-03-15 name: Second Affiliated Hospital of Xi'an Jiaotong University class: OTHER briefSummary: Melasma is a hyperpigmentary disorder of the skin especially of the face. Compared with normal skin, histologic features of melasma include the enhanced activity of melanocytes, higher solar elastosis in upper dermis, basement membrane disruption which promotes melanocytes and melanin into the dermis, increased vascularization, and an increased number of mast cells.
1927nm fractional laser was approved to treat melasma with no major side effects, however,hyperpigmentation and recurrence occasionally happened after laser therapy. Mast cells may paly a key role in the refractory melasma and hyperpigmentation. We hypothesized that laser treatment may stimulate the activation of pre-existing mast cell in melasma skin and promote mast cell proliferation and degranulation to release mediators such as histamine (HA). HA has been demonstrated to increase the melanin content and tyrosinase activity of melanocytes and induce melanogenesis and morphological changes by activating cAMP-PKA pathway through H2 receptors on melanocytes5. H2R antagonist(H2RA) can suppress pigmentation by reducing the increase of activated melanocytes by UVB irradiation.
In the present study, the investigators speculated that H2RA can enhance the efficacy of laser treatment of melasma and block the histamine-mediated melanogenesis and dendricity to prevent postoperative hyperpigmentation. The investigators combined 1927nm fractional laser with topical famotidine for melasma as a new therapeutic strategy to treat melasma.The investigators performed a split-face, single-blinded study to evaluate the efficacy and safety of 1927nm fractional laser with topical famotidine for the treatment of facial melasma. conditions: Melasma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 16 type: ACTUAL name: topical H2R antagonist name: Thulium 1927-nm Fractional Laser measure: Modified Melasma Area Severity Score（mMASI） measure: melanin index（MI） measure: erythema index(EI) measure: Melasma Quality of Life Index(MELASQoL) sex: FEMALE minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: The second affiliated hospital of Xi'an Jiaotong University city: Xi'an state: Shaanxi zip: 710000 country: China lat: 34.25833 lon: 108.92861 hasResults: False
nctId: NCT06313294 id: 230929002 briefTitle: Postoperative Follow-up Via Text Messages Automated Versus Telephone in Patients With Continuous Regional Anesthesia acronym: txt-RA overallStatus: NOT_YET_RECRUITING date: 2024-04-04 date: 2024-09-30 date: 2024-12-31 date: 2024-03-15 date: 2024-03-29 name: Pontificia Universidad Catolica de Chile class: OTHER briefSummary: Monitoring performed by a trained operator has proven to be useful and valued by patients after the use of continuous regional anesthesia. A health professional calls each patient to gather information about their recovery. However, this direct communication strategy requires time and resources, especially if many patients are involved.
The objective of the project is to evaluate the feasibility of monitoring through automated electronic messaging by evaluating its usability using a validated scale in Spanish. response rate on the first day and adherence rate compared to that of the traditional method. Secondarily, adherence and differences in satisfaction will be compared. conditions: Anesthesia conditions: Regional Anesthesia conditions: Nerve Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants will are assigned to one of two groups in parallel for the duration of the study primaryPurpose: DIAGNOSTIC masking: SINGLE maskingDescription: The research patients will be blind to the proposed intervention. whoMasked: PARTICIPANT count: 100 type: ESTIMATED name: Tracking application app name: Telephone interview measure: Usability level of the tracking application measure: Patient satisfaction with Perception of Quality in Anesthesia measure: Patient adherence sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pontificia Universidad Catolica de Chile city: Santiago state: Metropolitana zip: 450881 country: Chile name: Victor Contreras, MSN role: CONTACT phone: 223549217 email: vecontre@uc.cl name: Erick Strange, MD role: PRINCIPAL_INVESTIGATOR lat: -33.45694 lon: -70.64827 hasResults: False
nctId: NCT06313281 id: E-18-3331 briefTitle: Effectiveness of Preoperative Antiseptic Preparation in Transnasal Skull Base Surgery overallStatus: COMPLETED date: 2019-02-01 date: 2021-09-30 date: 2021-09-30 date: 2024-03-15 date: 2024-03-20 name: King Saud University class: OTHER briefSummary: Objective: Transnasal skull-base surgery is a complex and invasive procedure that involves the use of preoperative antiseptic preparations. However, evidence supporting their use in preventing postoperative infectious complications is limited. The aim of this study is to assess the efficacy of preoperative antiseptic techniques in reducing postoperative infectious complications within 30 days of surgery.
Methods: A multicenter, prospective, randomized, single-blind, three-arm trial was conducted from February 2019 to October 2021. Participants were randomized to either of three antiseptic preparation techniques: external 0.9%NaCl nasal preparation, external 0.05% chlorhexidine gluconate, or intranasal irrigation with 80 mg of gentamicin added to 1000 ml of 0.9%NaCl plus external nasal preparation with chlorhexidine gluconate 0.05%. A total of 130 adults with skull-base pathologies were randomized, 12 were excluded before randomization for failure to meet inclusion criteria (n=9) or refusal to participate (n=3). The investigators excluded patients with evidence of infection adjacent to the surgical site, allergies to preparation methods, those who underwent craniotomy during the same admission, and pediatric patients. conditions: Meningitis and Sinusitis in Transnasal Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 142 type: ACTUAL name: Preoperative Antiseptic preparation prior to transnasal skull base surgery measure: the difference in the incidence of postoperative infections within 30 days of surgery between the three interventional groups sex: ALL minimumAge: 14 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: King Saud University city: Riyadh zip: 12394 country: Saudi Arabia lat: 24.68773 lon: 46.72185 hasResults: False
nctId: NCT06313268 id: LT-02-20 briefTitle: Safety of Effivia®, a Bevacizumab Biosimilar overallStatus: RECRUITING date: 2022-04-21 date: 2024-02-20 date: 2024-06-30 date: 2024-03-15 date: 2024-03-15 name: Laboratorios Liomont class: INDUSTRY name: Servicios Especializados en Ensayos Clínicos, S.C. briefSummary: This is a post-marketing observational study aimed to evaluated the safety profile of Effivia®, a biosimilar of bevacizumab, in mexican patients with different types of cancer. conditions: Metastatic Colorectal Cancer conditions: Metastatic Cervical Cancer conditions: Non Squamous Non Small Cell Lung Cancer studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 95 type: ESTIMATED name: Bevacizumab Biosimilar MB02 measure: Adverse events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UMAE Hospital de Especialidades No. 1 status: RECRUITING city: León state: Guanajuato zip: 37320 country: Mexico name: David Suárez García, M.D. role: CONTACT phone: +524777174000 name: David Suárez García, M.D. role: PRINCIPAL_INVESTIGATOR lat: 21.12908 lon: -101.67374 facility: Hospital de Gineco-Obstetricia No. 3 status: RECRUITING city: Azcapotzalco state: Mexico City zip: 02990 country: Mexico name: Eliseo Neftalí de la Cruz Escobar, M.D. role: CONTACT phone: +525557821088 name: Eliseo Neftalí de la Cruz Escobar, M.D. role: PRINCIPAL_INVESTIGATOR lat: 19.48698 lon: -99.18594 facility: Hospital de Oncología, UMAE Centro Médico Nacional Siglo XXI status: RECRUITING city: Cuauhtémoc state: Mexico City zip: 06720 country: Mexico name: Alberto Alfonso Pimentel Rentería, M.D. role: CONTACT phone: +525556276900 name: Alberto Alfonso Pimentel Rentería, M.D. role: PRINCIPAL_INVESTIGATOR lat: 19.44506 lon: -99.14612 facility: Instituto Nacional de Cancerología status: RECRUITING city: Tlalpan state: Mexico City zip: 14080 country: Mexico name: David Francisco Cantú de León, M.D., Ph.D. role: CONTACT phone: +525556280400 name: David Francisco Cantú de León, M.D., Ph.D. role: PRINCIPAL_INVESTIGATOR lat: 19.29513 lon: -99.16206 facility: Hospital de Oncología IMSS Puebla status: RECRUITING city: Puebla zip: 07200 country: Mexico name: José Gustavo Núñez Cerrillo, M.D. role: CONTACT phone: +522222230690 name: José Gustavo Núñez Cerrillo, M.D. role: PRINCIPAL_INVESTIGATOR lat: 19.03793 lon: -98.20346 hasResults: False
nctId: NCT06313255 id: KYLL-202301-008-1 briefTitle: A Retrospective Observational Study on the Effects of Prebiotics on HBsAg Clearance overallStatus: RECRUITING date: 2023-05-09 date: 2025-12-31 date: 2025-12-31 date: 2024-03-15 date: 2024-03-15 name: Qilu Hospital of Shandong University class: OTHER briefSummary: The goal of this retrospective observational study is to find out the effects of prebiotics on HBV clearance. The main question it aims to answer is:
Researchers will compare the HBV clearance rate in chronic hepatitis B patients receive prebiotics and antiviral therapy with those receiving solely antiviral therapy. conditions: Chronic Hepatitis B studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 40 type: ESTIMATED name: PegIFNα2b name: PegIFNα2b+prebiotics name: Nucleoside analog name: Nucleoside analog+prebiotics measure: HBsAg clearance sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Qilu Hospital of Shandong University status: RECRUITING city: Jinan state: Shandong zip: 250012 country: China name: Yu-Chen Fan role: CONTACT phone: 0086+053182169596 email: fanyuchen@sdu.edu.cn name: Yu-Chen Fan role: PRINCIPAL_INVESTIGATOR lat: 36.66833 lon: 116.99722 hasResults: False
nctId: NCT06313242 id: 202403 briefTitle: Different Bowel Preparations in Magnetically Controlled Capsule Endoscopy overallStatus: RECRUITING date: 2024-03-14 date: 2025-02 date: 2025-06 date: 2024-03-15 date: 2024-03-19 name: Qilu Hospital of Shandong University class: OTHER briefSummary: The study aimed to compare the effects of bowel preparation methods of a normal diet for 1 day, a low residue diet for 1 day, and laxative bowel cleaning on the image quality of magnetically controlled capsule endoscopy, and to assess the rate of completion of the examination, small intestine transit time, lesion detection, patient tolerance, and safety of the three regimens. conditions: Magnetically Controlled Capsule Endoscopy conditions: Bowel Preparation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 375 type: ESTIMATED name: Polyethylene Glycol Electrolytes Powder (II) name: Low residue diet name: Normal diet measure: Image quality of small intestine measure: Rate of completion of inspections measure: Small intestine transit time measure: Lesion detection rate measure: Patient tolerance measure: Rate of adverse events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Qilu Hospital of Shandong University status: RECRUITING city: Jinan country: China name: Feixue Chen role: CONTACT phone: +8618560086108 email: chenfeixue@email.sdu.edu.cn lat: 36.66833 lon: 116.99722 hasResults: False