hackint0sh/New-Dataset huggingface dataset:
Hypothesis 3: Improvements in muscle soreness would only be observed in localized muscles around where the CBD cream was applied. conditions: Muscle Soreness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: The research participant's and research personnel conducting the testing will be blinded to who is in the CBD and placebo groups throughout the study. Those in Group 3 (the control group) will be aware that they are in the control group, as they will be skipping the steps involving cream application. The protocols for Group 1 and Group 2 will be identical and the respective cream will be made available to the testers and participants in identical containers. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 30 type: ACTUAL name: Cannabidiol cream name: Placebo cream measure: Vertical Jump Test measure: Peak Isokinetic Torque Test measure: Pressure-Pain Threshold Test sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Seaton Center Building city: Lexington state: Kentucky zip: 40502 country: United States lat: 37.98869 lon: -84.47772 facility: Multidisciplinary Science Building city: Lexington state: Kentucky zip: 40536 country: United States lat: 37.98869 lon: -84.47772 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2022-08-04 uploadDate: 2024-03-13T17:59 filename: ICF_000.pdf size: 187622 hasResults: False
nctId: NCT06320314 id: LRP23021-E serum briefTitle: Efficacy and Tolerability of Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins overallStatus: RECRUITING date: 2024-02-19 date: 2024-05-22 date: 2024-05-22 date: 2024-03-20 date: 2024-03-20 name: Cosmetique Active International class: INDUSTRY briefSummary: The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to moderate melasma, or mild to moderate acne induced post-inflammatory hyperpigmentation, or solar lentigo. conditions: Hyperpigmentation studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 60 type: ESTIMATED name: tested product (2039125 03) measure: IGA score for patients with melasma or acne induced post-inflammatory hyperpigmentation (PIHP) measure: modified Melasma Area and Severity Index (mMASI) for patients with melasma measure: Post-Acne Hyperpigmentation Index (PAHPI) measure: colorimetry measurements sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: PhDTrials Center status: RECRUITING city: Lisboa country: Portugal name: Pedro Pinto role: CONTACT phone: +351 216034267 phoneExt: 501 email: geral@phdtrials.com lat: 38.71667 lon: -9.13333 hasResults: False
nctId: NCT06320301 id: SYSKY-2024-027-01 briefTitle: Adebrelimab and a TKI in Combination With GEMOX in First-line Treatment of Advanced Biliary Tract Cancers (BTC) overallStatus: RECRUITING date: 2024-04-01 date: 2026-02-01 date: 2026-06-01 date: 2024-03-20 date: 2024-03-20 name: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University class: OTHER name: Suzhou Suncadia Biopharmaceuticals Co., Ltd. briefSummary: Patients with advanced biliary tract malignant tumors who had not received systematic treatment before and could not be cured were selected as the subjects of the study. The primary endpoint of the study was investigator-assessed 6-month progression-free survival (6-month PFS%) based on the RECIST v1.1 criteria, and 43 subjects were planned to be enrolled. Patients eligible for enrollment will receive Adebrelimab and a tyrosine kinase inhibitor (TKI) in combination with gemcitabine and oxaliplatin (GEMOX). conditions: Biliary Tract Cancer conditions: Gemox Chemotherapy studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 43 type: ESTIMATED name: Adebrelimab + GEMOX + TKI measure: the effectiveness of first-line treatment with Adebrelimab and a tyrosine kinase inhibitor (TKI) in combination with gemcitabine and oxaliplatin (GEMOX) in patients with advanced BTC measure: To assess the progression-free survival (PFS) measure: To evaluate the time to progression (TTP) measure: To evaluate the disease control rate (DCR), measure: To evaluate the objective response rate (ORR) measure: To evaluate the duration of response (DoR) measure: To evaluate the overall survival (OS). measure: To explore the correlation between biomarkers and the efficacy of the combination regimen. measure: The PFS based on an immunomodified RECIST (imRECIST） measure: The TTP based on an immunomodified RECIST (imRECIST） measure: The ORR based on an immunomodified RECIST (imRECIST） measure: The DCR based on an immunomodified RECIST (imRECIST） measure: The DoR based on an immunomodified RECIST (imRECIST） sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Sun Yat-sen Memorial Hospital, Sun Yat-sen University status: RECRUITING city: Guanzhou state: Guangdong zip: 512000 country: China name: Junkai Ren role: CONTACT phone: 86-18664506517 email: rjk119234@163.com name: Wenbin Li role: CONTACT phone: 86-13602773101 hasResults: False
nctId: NCT06320288 id: IRR-FLAVIGNY-2023-1 briefTitle: Analysis of Trunk and Center of Mass Control Development During Gait in Children With Cerebral Palsy (VERTEBRAL) acronym: VERTEBRAL overallStatus: RECRUITING date: 2023-09-20 date: 2025-09 date: 2028-09 date: 2024-03-20 date: 2024-03-20 name: Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est class: OTHER briefSummary: During the acquisition of posturokinetic abilities such as walking, postural control of the trunk is of paramount importance. Indeed, its development is strongly linked to the overall motor function of children. In cerebral palsy (CP), a term that refers to a set of motor disorders following a perinatal lesion, deficits in axial control are present from early childhood. These deficits are strongly correlated with the functional deficits observed in this population. In particular, during walking, deviations of the trunk (amplitudes, accelerations) are observed in the three planes of space. While recent literature increasingly questions the impact of trunk control deficit on the walking of children with CP, elements are still missing for a holistic understanding of the interaction between locomotor and postural disorders in children with CP. In particular, no study has focused on the deviations of trunk control and the center of mass (which is a global indicator of balance strategies) during the development and maturation of walking in children with CP. Therefore, the primary objective of this cross-sectional observational study will be to characterize the development of trunk control and center of mass during walking in children with CP. conditions: Children With Cerebral Palsy studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 270 type: ESTIMATED measure: Trunk and center-of-mass accelerations and acceleration variability measure: Gait Variability Index measure: Trunk Control Measurement Scale score (TCMS) measure: Early Clinical Assessment of Balance score sex: ALL minimumAge: 18 Months maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Institut Régional de Médecine Physique et de Réadaptation status: RECRUITING city: Nancy zip: 54000 country: France name: Jonathan Pierret, PhD role: CONTACT phone: +33 3 82 52 6761 email: jonathan.pierret@ugecam.assurance-maladie.fr lat: 48.68439 lon: 6.18496 hasResults: False
nctId: NCT06320275 id: self-efficiency briefTitle: Fathers' Breastfeeding Self-efficiency overallStatus: COMPLETED date: 2023-02-01 date: 2023-05-30 date: 2023-07-30 date: 2024-03-20 date: 2024-03-20 name: Cukurova University class: OTHER briefSummary: The purpose of this study was planned to examine the effect of the education given through digital storytelling method on fathers' breastfeeding self-efficacy perception. The research is in a quasi-experimental design with no pretest-posttest control group. conditions: FATHER conditions: BREASTFEEDING studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: INVESTIGATOR count: 80 type: ACTUAL name: Storytelling Intervention measure: Breastfeeding Self-Efficacy Scale for Fathers Short Form sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cukurova University city: Adana state: Balcalı zip: 01 330 country: Turkey lat: 37.00167 lon: 35.32889 facility: Çukurova city: Adana state: Balcalı zip: 01330 country: Turkey lat: 37.00167 lon: 35.32889 facility: Çukurova University city: Adana zip: 01330 country: Turkey lat: 37.00167 lon: 35.32889 hasResults: False
nctId: NCT06320262 id: NRC/TDF/01/F briefTitle: Evaluation of the Effect of Wet Cupping (Hijama) on Primary Fibromyalgia overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-10 date: 2025-04 date: 2024-03-20 date: 2024-03-22 name: Rasmia Elgohary class: OTHER briefSummary: Fibromyalgia has become one of the most prevalent chronic pain conditions that impair quality of life. Wet cupping has gained increasing popularity in treating painful conditions.
This study aims to investigate the effectiveness of wet cupping therapy combined with home-based exercise compared to home-based exercise alone in improving patients diagnosed with primary fibromyalgia syndrome. conditions: Treatment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized controlled drugs primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: Wet cupping therapy (WCT) measure: Change from baseline brain MRS measure: Change from baseline Visual Analog Scale (VAS) measure: Change from baseline in the individual components of the Fibromyalgia Impact Questionnaire Revised (FIQR) measure: Change from the baseline sleep disturbance using the Jenkins sleep score (JSS) measure: Change from baseline Fatigue- VAS. measure: Change from baseline of Hospital Anxiety and Depression Scale (HADS) measure: Change from baseline of the Montreal Cognitive Assessment (MoCA) measure: Change from baseline of the Widespread pain index (WPI) measure: Change from baseline hemoglobin measure: patient compliance on exercise as instructed sex: FEMALE minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT hasResults: False
nctId: NCT06320236 id: 4603 briefTitle: Emergency Medicine Pulmonary Embolism Testing Multicentre Study acronym: EMPET overallStatus: RECRUITING date: 2024-01-01 date: 2026-09-30 date: 2027-09-30 date: 2024-03-20 date: 2024-03-20 name: Dr. Kerstin de Wit class: OTHER name: Canadian Institutes of Health Research (CIHR) briefSummary: It is important to diagnose pulmonary embolism in a timely manner to prevent death and long-term disability. More than half a million people (4-5% of emergency department patients) are tested for pulmonary embolism, although positive results are low. Imaging for PE testing exposes patients to radiation, is expensive, adds time to the emergency visit, and can lead to a false positive diagnoses. Existing protocols aimed at reducing unnecessary pulmonary embolism imaging are complex and seldom used by emergency physicians. Too many patients undergo unnecessary pulmonary embolism imaging.
Our study aim is to prospectively validate Adjust-Unlikely pulmonary embolism testing in emergency patients with suspected pulmonary embolism. conditions: Pulmonary Embolism conditions: D-dimer conditions: Diagnosis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 4000 type: ESTIMATED name: Adjust-Unlikely measure: Venous thrombosis measure: Venous thrombosis measure: Index presentation Adjust-Unlikely testing results sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kingston Health Sciences Centre status: RECRUITING city: Kingston state: Ontario zip: K7L 2V7 country: Canada name: Natasha Clayton, CRA, RA role: CONTACT phone: 4165663590 email: natasha.clayton@queensu.ca name: Kerstin de Wit, MD role: PRINCIPAL_INVESTIGATOR lat: 44.22976 lon: -76.48101 hasResults: False
nctId: NCT06320223 id: PROMISE PET Registry briefTitle: PROMISE PET Registry on PSMA-PET and Outcome in Prostate Cancer acronym: PROMISE-PET overallStatus: RECRUITING date: 2024-03-05 date: 2034-03-05 date: 2035-03-05 date: 2024-03-20 date: 2024-03-20 name: University Hospital, Essen class: OTHER briefSummary: Background:
* Patients with metastasized or disseminated malignancy other than prostate cancer conditions: Prostate Cancer conditions: PET/CT conditions: Survivorship conditions: PSMA studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 10000 type: ESTIMATED measure: Overall survival measure: Metastasis-free survival sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Essen status: RECRUITING city: Essen zip: 45147 country: Germany name: Wolfgang P Fendler, M.D. role: CONTACT phone: +492017232032 email: redcap@ikim.nrw lat: 51.45657 lon: 7.01228 hasResults: False
nctId: NCT06320210 id: IRB19-1308 briefTitle: Chicago Asthma School-Directed Child-Centered Assessment and Dissemination of Evidence acronym: CASCADE overallStatus: RECRUITING date: 2023-08-31 date: 2025-08-31 date: 2025-12-30 date: 2024-03-20 date: 2024-04-11 name: University of Chicago class: OTHER briefSummary: Research has shown that adherence to evidence-based asthma guidelines leads to improved outcomes, yet critical gaps remain in the implementation of these guidelines, particularly among minority and low-income youth. Schools represent a crucial point of intervention, as demonstrated by school-based asthma programs that have addressed individual components of the guidelines with promising results. This project aims to develop, implement, and evaluate a pragmatic, multi-component asthma program that builds upon existing targeted interventions to fully implement the asthma guidelines and integrate them in school practices to foster sustainability. The investigator seeks to understand whether this type of program will improve asthma outcomes at the child and school level. conditions: Asthma in Children studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 400 type: ESTIMATED name: Multicomponent program measure: Asthma control measure: Missed work days in parents measure: Asthma knowledge - parents measure: Asthma knowledge - child measure: Asthma quality of life - child measure: Caregiver quality of life measure: Asthma impact - parent measure: Missed school days measure: Healthcare utilization measure: Asthma impact - child sex: ALL minimumAge: 4 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: University of Chicago Charter Schools status: RECRUITING city: Chicago state: Illinois zip: 60640 country: United States lat: 41.85003 lon: -87.65005 hasResults: False
nctId: NCT06320197 id: DROWN_INSITU briefTitle: In Situ Simulation Training in Lifeguard Organisations acronym: DROWN_INSITU overallStatus: RECRUITING date: 2018-01-01 date: 2024-12-31 date: 2024-12-31 date: 2024-03-20 date: 2024-03-20 name: Prehospital Center, Region Zealand class: OTHER briefSummary: This retrospective study will analyse a dataset consisting of 919 in situ simulation assessments collected between 2018 and 2023 in a Danish nationwide surf lifeguard organisation. The primary objective is to estimate the pass/fail ratio of in situ simulation assessments. The secondary objective is to analyse risk factors associated with a failed assessment. These results may guide future efforts to improve the Danish surf lifeguard training program. conditions: Drowning conditions: Drowning, Near conditions: Drowning and Nonfatal Submersion conditions: Drowning/Submersion conditions: Drowning and Submersion While in Natural Water studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 1000 type: ESTIMATED name: In situ simulation assessment measure: Pass/fail ratio of in situ simulation assessments measure: Risk factors associated with a failed assessment sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Prehospital Center status: RECRUITING city: Næstved state: Region Zealand zip: 4700 country: Denmark name: Niklas Breindahl, MD role: CONTACT phone: 004528566410 email: niklas.breindahl@regionh.dk name: Helle Collatz Christensen, MD, PhD role: CONTACT phone: 004521673452 email: helle.collatz.christensen.02@regionh.dk lat: 55.22992 lon: 11.76092 hasResults: False
nctId: NCT06320184 id: INT 0083/23 briefTitle: AI for Lung Cancer Risk Definition in Computed Tomography Screening Programs overallStatus: ACTIVE_NOT_RECRUITING date: 2023-04-30 date: 2024-10-30 date: 2026-04-30 date: 2024-03-20 date: 2024-03-22 name: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano class: OTHER name: University of Milano Bicocca briefSummary: Low-dose computed tomography (LDCT) lung cancer (LC) screening can reduce mortality among heavy smokers, but there is a critical need to better identify people at higher risk and to reduce harms related to management of benign nodules. The most promising strategy is to combine novel tools to optimize clinical decisions and increase the benefit of screening.
In this respect, the investigators already demonstrated that the combination of baseline LDCT features with a minimal invasive microRNA blood test was able to more precisely estimate the individual risk of developing LC. The investigators posit that additional immune-related and radiologic features can be integrated with the help of artificial intelligence (AI) to further implement LDCT screening strategies. The project will answer whether the combination of (bio)markers of different origin can predict LC development at baseline and over time, indicate which screen-detected lung nodules are likely to be malignant and ultimately reduce LC and all cause mortality. conditions: Lung Cancer conditions: Blood Biomarkers studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 650 type: ACTUAL name: Artificial Intelligence risk model measure: Aim 1 measure: Aim 2 measure: Aim 3 sex: ALL minimumAge: 50 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione IRCCS Istituto Nazionale dei Tumori city: Milan zip: 20133 country: Italy lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06320171 id: 240118,2024-481 briefTitle: Efectivity of Non-invasive Neuromodulation in Parasympathic Nervous System and Vascular System overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-04 date: 2024-06 date: 2024-03-20 date: 2024-03-20 name: Universidad Europea de Madrid class: OTHER briefSummary: The study, conducted by the Universidad Europea de Madrid, examines the immediate effects of a single session using NESA microcurrents on various circulatory system variables in healthy subjects. It divides participants into three groups based on session duration (15, 30, 45 minutes), measuring pre and post-intervention changes. The focus is on autonomic nervous system responses, aiming to understand the minimum treatment characteristics needed for significant autonomic changes. Variables studied include systolic and diastolic blood pressure, heart rate, and several ultrasound measurements of the common carotid artery (CSA), including thickness and peak systolic flow velocity. conditions: Hypertension studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: Non-Invasive neuromodulation measure: Systolic and diastolic Blood Pressure: measure: Heart rate measure: Ultrasonographic variables: Cross-sectional area of the jugular vein measure: Ultrasonographic variables:Cross-sectional area of the common carotid measure: Ultrasonographic variables:Thickness of the common carotid measure: Ultrasonographic variables:Peak systolic velocity. measure: Cortisol measurement sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06320158 id: PNRR-MAD-2022-12376672 briefTitle: Dissecting the Molecular and Cellular Pathophysiology of Sarcopenic Obesity in the Elderly overallStatus: RECRUITING date: 2023-05-22 date: 2024-10-31 date: 2024-12-31 date: 2024-03-20 date: 2024-03-28 name: IRCCS San Raffaele class: OTHER briefSummary: Ageing is characterised by a change in body composition with a parallel decrease in muscle mass and an increase and central redistribution of fat. When drastically exacerbated, these two processes culminate in a condition known as sarcopenic obesity (SO). SO is characterised by the coexistence of obesity and sarcopenia (i.e. reduced muscle mass and function) and is a growing public health problem in the elderly. The health risks of obesity and sarcopenia act synergistically, maximising the risk of disability of OS. The molecular mechanisms underlying OS are largely unknown. Increased fat mass induces chronic systemic inflammation and alters the profiles of adipokines and hormones, promoting the development of sarcopenia. On the other hand, the reduction in muscle tissue (SM) typical of sarcopenia is characterised by an alteration in the metabolic properties of skeletal muscle with an increase in insulin resistance and a reduction in energy expenditure that favours the accumulation and dysfunction of adipose tissue (AT). The cellular alterations that would seem to underlie OS are: altered autophagy, cellular senescence, epigenetic and mitochondrial alterations and maladaptive activation of intra- and intercellular inflammatory circuits (e.g. cytokines, extracellular vesicles, dysfunctional circulating leukocytes). However, the interconnections between these mechanisms are still unclear. The impact of OS can be dramatic on the health and quality of life of those affected. Therefore, the identification of early biomarkers that can recognise overweight and obese individuals at risk of developing SO is of paramount importance. This would shed light on the heterogeneity of an otherwise homogeneous clinical condition, opening new horizons towards the conscious design of more personalised therapeutic strategies, allowing a more rational use of the limited resources available for the growing elderly population.
The study design designed to achieve this aim is a cross-sectional observational study with an additional multicentre procedure lasting two years. conditions: Sarcopenic Obesity studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1108 type: ESTIMATED name: clinical evaluation of sarcopenic obesity measure: Identifying new molecular markers in elderly patients with sarcopenic obesity measure: Assessing the ability of new markers (identified in the pre-clinical phase of this project) to predict individual disease trajectories sex: ALL minimumAge: 65 Years maximumAge: 99 Years stdAges: OLDER_ADULT facility: Ospedale San Raffaele status: RECRUITING city: Milan zip: 20132 country: Italy name: Patrizia Rovere Querini, MD, PhD role: CONTACT phone: +390226433065 email: rovere.patrizia@hsr.it name: Rebecca De Lorenzo, MD role: CONTACT phone: +390226433065 email: delorenzo.rebecca@hsr.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06320145 id: P.T.REC/012/004045 briefTitle: Effect of Cryotherapy on Primary Dysmenorrhoea overallStatus: COMPLETED date: 2023-03-13 date: 2023-09-13 date: 2023-10-01 date: 2024-03-20 date: 2024-03-20 name: Cairo University class: OTHER briefSummary: Dysmenorrhea is a menstrual disorder defined by the presence of painful cramps of uterine origin that occur during menstruation. It is one of the most common causes of pelvic pain and short-term absenteeism from school or work, among young and adult women.