hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06277635 id: TAPAC001 briefTitle: Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases overallStatus: RECRUITING date: 2024-02-01 date: 2025-04 date: 2025-04 date: 2024-02-26 date: 2024-02-26 name: Phramongkutklao College of Medicine and Hospital class: OTHER briefSummary: To study the effect of silymarin against methotrexate-induced liver injury in rheumatic diseases including rheumatoid arthritis, psoriatric arthritis and psoriasis conditions: Rheumatoid Arthritis conditions: Psoriatic Arthritis conditions: Psoriasis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 72 type: ESTIMATED name: Silymarin name: Placebo measure: AST or ALT > 1X ULN ( normal AST and ALT 0-50 U/L) measure: AST or ALT > 2X ULN ( normal AST and ALT 0-50 U/L) AST or ALT > 2X ULN AST or ALT > 2X ULN measure: AST or ALT > 3X ULN ( normal AST and ALT 0-50 U/L) measure: AST or ALT > 5X ULN or >3X ULN ( normal AST and ALT 0-50 U/L) with symptom of hepatitis such as Fatique, abdominal pain, nausea, vomiting or total bilirubin > 2X with jaundice measure: Discontinuation rate of methotrexate measure: Adverse events measure: Change of DAS-28 ESR or CRP Score measure: Change of BASDAI Score measure: Change of ASDAS ESR or CRP Score measure: Change of BSA for psoriasis sex: ALL minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Rheumatic Disease Unit, Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine status: RECRUITING city: Bangkok, Thailand, 10400 state: Bangkok zip: 10400 country: Thailand name: Rattapol Pakchotanon, M.D. role: CONTACT phone: 66+23547980 email: rattapolpmk@gmail.com name: Rattapol Pakchotanon, M.D. role: SUB_INVESTIGATOR name: Supasa Niyompanichakarn, M.D. role: SUB_INVESTIGATOR lat: 13.75398 lon: 100.50144 hasResults: False
nctId: NCT06277622 id: PekingUTH ZFCY PFUN briefTitle: A Prospective Multicenter Cohort Study About Internal Fixation Using PFUN Versus PFNA for Femoral Intertrochanteric Fracture overallStatus: RECRUITING date: 2024-01-01 date: 2025-09-30 date: 2025-12-31 date: 2024-02-26 date: 2024-02-26 name: Peking University Third Hospital class: OTHER name: Beijing Yanqing Hospital briefSummary: This prospective multicenter cohort study is to compare the post-operative implant failure rate between the patients with femoral intertrochanteric fracture (AO classification 31-A) using Proximal Femoral Universal Nail (PFUN) versus Proximal Femoral Nail Antirotation (PFNA) at 21-month follow up. The patients are divided into the PFUN group and the PFNA group according to the internal fixation they choose. The internal fixation failure rate (IFFR) and differences in fracture prognosis of the two groups will be compared. Obtain clinical data of PFUN in the Chinese population, and verify the safety and efficacy of PFUN for patients with femoral intertrochanteric fracture. conditions: Femoral Intertrochanteric Fractures studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This prospective multicenter cohort study is to compare the post-operative implant failure rate between the patients with femoral intertrochanteric fracture (AO classification 31-A) using Proximal Femoral Universal Nail (PFUN) versus Proximal Femoral Nail Antirotation (PFNA) at 21-month follow up.The patients are divided into the PFUN group and the PFNA group according to the internal fixation they choose. primaryPurpose: TREATMENT masking: NONE count: 130 type: ESTIMATED name: PFUN name: PFNA measure: Internal fixation failure rate measure: Number of Participants with Bone nonunion measure: Harris hip score measure: operation time measure: The times of intraoperative fluoroscopy measure: Number of Participants with Postoperative adverse events sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking University Third Hospital status: RECRUITING city: Beijing state: Beijing zip: 100191 country: China name: Yuan Cao, MD role: CONTACT phone: +86-01082266699 email: cy6415@126.com name: Fang Zhou, MD role: CONTACT phone: +86010-82267010 email: zhouf@bjmu.edu.cn lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06277609 id: 20508A briefTitle: A Trial Investigating Lu AF28996 in Healthy Adult Participants overallStatus: RECRUITING date: 2024-02-27 date: 2024-05-18 date: 2024-05-18 date: 2024-02-26 date: 2024-03-07 name: H. Lundbeck A/S class: INDUSTRY briefSummary: The purpose of this study is to investigate repeated doses of Lu AF28996 in healthy participants and co-administered with two other compounds, and in a separate cohort following co-administration with antibiotics, to see how well the doses are tolerated and what the body does to the drug after administering it. conditions: Healthy Participants studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 24 type: ESTIMATED name: Lu AF28996 name: Acetylsalicylic Acid name: Mefenamic Acid name: Amoxicillin/clavulanic acid measure: Maximum Observed Concentration (Cmax) of Lu AF28996 measure: Area Under the Plasma Concentration-Time Curve From Time 0 to Infinity (AUC0-inf) of Lu AF28996 measure: Nominal Time Corresponding to the Occurrence of Cmax sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Covance Dallas CRU status: RECRUITING city: Dallas state: Texas zip: 75247 country: United States lat: 32.78306 lon: -96.80667 hasResults: False
nctId: NCT06277596 id: ETK00-2023-0101 briefTitle: The Effects of Progressive Clinical Pilates Exercises Applied as 2 Different Ways in Fibromyalgia overallStatus: RECRUITING date: 2024-04-10 date: 2024-07-30 date: 2024-08-30 date: 2024-02-26 date: 2024-04-16 name: Eastern Mediterranean University class: OTHER briefSummary: The aim of this study is to compare the effects of progressive clinical Pilates exercises applied as group under the supervision of a physiotherapist and home exercise programs on pain level, physical condition, functional status, psychosocial status and quality of life in individuals with fibromyalgia between the ages of 20-50. conditions: Fibromyalgia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 48 type: ESTIMATED name: Exercise measure: Visual Analog Scale ( VAS ) measure: Sociodemographic information (age) measure: Sociodemographic information (height) measure: Sociodemographic information (weight) measure: Trunk Muscle Endurance (McGill Endurance Test and Plank Test) measure: Chair Sit to stand test measure: 6 minute walk test measure: Fatigue Severity Scale measure: Pittsburgh Sleep Quality Index measure: Revised Fibromyalgia Impact Questionnaire measure: Fear-Avoidance Beliefs Questionnaire measure: Pain Self-Efficacy Questionnaire measure: Body Awareness Questionnaire measure: Cognitive Exercise Therapy Approach-Biopsyhosocial Questionnaire (BETY-BQ) measure: Short form-36 (SF-36) measure: Treatment Satisfaction Evaluation sex: ALL minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT facility: Eastern Mediterranean University status: RECRUITING city: Famagusta zip: 99628 country: Cyprus name: Sevim Oksüz, Asst.Prof.Dr role: CONTACT phone: 5488351465 phoneExt: +90 email: sevim.oksuz@emu.edu.tr lat: 35.12054 lon: 33.93894 hasResults: False
nctId: NCT06277570 id: 2023-487 briefTitle: Investigation of the Effect of Superimposed Neuromuscular Electrical Stimulation in Patients With Knee Osteoarthritis. overallStatus: RECRUITING date: 2023-10-31 date: 2025-03-31 date: 2025-06-30 date: 2024-02-26 date: 2024-02-26 name: Gulhane School of Medicine class: OTHER briefSummary: The aim of the study is to investigate the effects of superimposed neuromuscular electrical stimulation with active contraction on physical function, muscle and joint structure, functionality, and quality of life in patients with knee osteoarthritis. conditions: Knee Osteoarthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The sample of the study will consist of participants who applied to Etlik City Physical Therapy and Rehabilitation Hospital, were diagnosed with knee osteoarthritis by the physician, and will receive routine treatment in the electrotherapy unit. Patients will be randomly assigned to groups. primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 63 type: ESTIMATED name: conventional physiotherapy name: NMES name: Superimposed NMES measure: Muscle strength measure: Joint position sense measure: Muscle structure and knee joint cartilage thickness measure: Joint range of motion measure: Short Form-36 measure: Western Ontario and McMaster Universities Osteoarthritis Index Scale measure: Visual Analog Scale (VAS) measure: Balance assessment measure: Functional capacity sex: ALL minimumAge: 40 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Physiotherapy and Rehabilitation, University of Health Sciences status: RECRUITING city: Ankara state: Etlik zip: 06018 country: Turkey name: Oğuzhan METE role: CONTACT email: oguzhan.mete@sbu.edu.tr lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06277557 id: HSEARS20211229002 briefTitle: Evaluation of the Effects of Virtual Reality Learning Environment on Nursing Student Non-technical Skills Development overallStatus: COMPLETED date: 2022-01-10 date: 2023-08-31 date: 2023-08-31 date: 2024-02-26 date: 2024-02-26 name: The Hong Kong Polytechnic University class: OTHER briefSummary: The goal of this waitlist control study is to evaluate the benefits of virtual reality teaching pedagogy to developing non-technical skills in nursing students.
Participants will attend the Virtual Reality training program. Researchers will compare the use of high-fidelity simulation to see if the non-technical skills were developed. conditions: Educational Problems studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SEQUENTIAL interventionModelDescription: Waitlist-control study primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 180 type: ACTUAL name: Virtual Reality measure: Situation awareness and communication skills measure: Student's self-confidence in learning measure: Participants' sense of presence in this virtual clinical environment sex: ALL minimumAge: 18 Years maximumAge: 22 Years stdAges: ADULT facility: Timothy LAI city: Kowloon country: Hong Kong lat: 22.31667 lon: 114.18333 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2022-01-01 uploadDate: 2024-02-18T20:16 filename: Prot_SAP_000.pdf size: 840053 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2022-01-01 uploadDate: 2024-02-18T20:16 filename: ICF_001.pdf size: 720367 hasResults: False
nctId: NCT06277544 id: M2024087 briefTitle: Analysis of Prognosis and Risk Factors of LAL Reconstruction Procedure for Patients With AF of the LAL: a Prospective Cohort Study overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-27 date: 2026-06-30 date: 2026-06-30 date: 2024-02-26 date: 2024-02-26 name: Peking University Third Hospital class: OTHER briefSummary: To compare the clinical outcomes of CAI patients with and without lateral ankle avulsion fracture after ligament repair/reconstruction, and to analyze the risk factors associated with the outcome. conditions: Avulsion Fracture of Lateral Ankle Ligament studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 120 type: ESTIMATED name: lateral ankle ligament repair or reconstruction measure: Karlsson score measure: Visual Analogue Scale (VAS) measure: American Orthopaedic Foot and Ankle Society (AOFAS) measure: Tegner Scale sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Peking University Third Hospital city: Beijing country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06277531 id: IRB00006761-M2024086 briefTitle: Evaluation of diagnostiC Capacity of eccDNAs as Biomarkers in Indetermined biLiary Stricture(ECCBILE) acronym: ECCBILE overallStatus: RECRUITING date: 2024-03-01 date: 2026-03-01 date: 2027-03-01 date: 2024-02-26 date: 2024-04-03 name: Peking University Third Hospital class: OTHER name: Beijing Tsinghua Changgeng Hospital briefSummary: Biliary stricture is mainly malignant in the adults and caused by several types of fatal malignancies such as pancreatic cancer, cholangiocarcinoma, and metastatic tumor, which have poor prognosis that the overall survival of unresectable lesions is no more than 15 months. The poor outcome often relates to a lack of reliable strategies for early diagnosis, which results in most patients with malignant biliary stricture being already advanced-stage disease at presentation. Therefore, it is critical to discover novel and effective strategies for the early diagnosis of malignant biliary strictures.
In the previous study, the investigators found that bcf-eccDNA has excellent diagnostic value in predicting uncertain bile duct stricture, and the sensitivity and specificity of a related eccDNA in 40 samples are 80.8% and 100%. The sensitivity and specificity of another eccDNA were 92.3% and 92.9%, respectively. However, the sample size is still relatively small, and further prospective studies are needed to evaluate its diagnostic efficacy. conditions: Biliary Stricture conditions: Bile Duct Cancer conditions: Pancreas Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 99 type: ESTIMATED measure: Patient is diagnosed with malignant disease from biliary system sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking University Third Hospital status: RECRUITING city: Beijing state: Beijing zip: 1000191 country: China name: Zhuo Cheng, M.D. role: CONTACT phone: +86-18701012781 email: chengzhuo321@pku.edu.cn lat: 39.9075 lon: 116.39723 facility: Beijing Tsinghua Changgung Hospital status: RECRUITING city: Beijing state: Beijing zip: 102218 country: China name: Xiue Yan, M.D. role: CONTACT phone: +86-15811117418 email: pskyq@163.com lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06277518 id: Liqin Deng briefTitle: System for Postoperative Admission to ICU for Patients With Digestive System Malignancy overallStatus: ACTIVE_NOT_RECRUITING date: 2023-09-20 date: 2025-12 date: 2026-06-20 date: 2024-02-26 date: 2024-02-26 name: General Hospital of Ningxia Medical University class: OTHER briefSummary: Postoperative admission to ICU for patients with digestive system tumors is one of the most common postoperative complications of all non-cardiac surgeries. The study found that supportive treatment of critically ill patients admitted to ICU after surgery was conducive to reducing mortality, and the most common complications of postoperative ICU admission were infections, especially respiratory infections and surgical site infections. A growing body of evidence supports that ICU stays are expensive, always occupy major hospital resources, and are associated with the worst outcomes. To date, there is insufficient evidence to determine which patients with digestive system tumors benefit the most from being admitted to the ICU after surgery. Therefore, this study intends to adopt retrospective study to determine the risk factors of postoperative ICU transfer for patients with digestive system malignant tumor, and build a risk prediction model for postoperative ICU admission, so as to guide the decision of postoperative ICU transfer for patients with digestive system malignant tumor. conditions: Intensive Care Unit Syndrome studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: RETROSPECTIVE count: 2000 type: ACTUAL name: Surgery for malignant tumors of the digestive system measure: admitted to ICU after surgery sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: General Hospital of Ningxia Medical University city: Yinchuan state: Ningxia zip: 750004 country: China lat: 38.46806 lon: 106.27306 hasResults: False
nctId: NCT06277505 id: 2023(164) briefTitle: Efficacy and Safety Evaluation of Prebiotics Combined With Quadruple Probiotics in Improving Functional Constipation. overallStatus: ENROLLING_BY_INVITATION date: 2024-02-20 date: 2024-04-20 date: 2024-06-20 date: 2024-02-26 date: 2024-02-26 name: The First Affiliated Hospital of Xiamen University class: OTHER briefSummary: The purpose of this study is to analyze the intestinal microecology of patients with functional constipation before and after treatment through intestinal microecological intervention, mainly using the combination of probiotics and prebiotics. We will record the patient's stool diary, including bowel movements, stool quality, bowel time, defecation difficulty, emptying sensation, manual operation and medication. At the same time, we will use the Bristol Fecal Traits Scale (BSFS) and the Constipation Patient Self-Rating Scale (PAC-SYM) and Constipation Patient Quality of Life Scale (PAC-QOL) scores completed weekly. In addition, we will monitor indicators of inflammation (IL-1β, IL-6, TNF-alpha) and intestinal barrier function (LPS), neurotransmitter (serotonin, acetylcholine)) to assess constipation improvement in patients with functional constipation. conditions: Effect of Prebiotics and Probiotics on Functional Constipation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Take prebiotics and probiotics name: lifestyle guidance measure: Change in the number of fully autonomous bowel movements per week at the end of treatment sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: The First Affiliated Hospital of Xiamen Univisity city: Xiamen state: Fujian zip: 350000 country: China lat: 24.47979 lon: 118.08187 hasResults: False
nctId: NCT06277492 id: GN-001 briefTitle: A First-In-Human Study of Single and Multiple Ascending Doses of Oral SUL-238 in Healthy Subjects overallStatus: RECRUITING date: 2024-02-19 date: 2025-08-09 date: 2025-11-08 date: 2024-02-26 date: 2024-02-26 name: GEN İlaç ve Sağlık Ürünleri A.Ş. class: INDUSTRY name: Sulfateq B.V. briefSummary: The goal of this randomized, double-blind, placebo-controlled, single-center study is to evaluate the safety, tolerability, pharmacokinetics of single and multiple oral doses of SUL-238 in healthy subjects (aged ≥40 years). conditions: Healthy Subjects studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 69 type: ESTIMATED name: Single ascending doses SUL-238 name: Single dose Placebo name: Single dose SUL-238 name: Multiple ascending doses SUL-238 name: Multiple doses Placebo measure: Incidence of Treatment-Emergent Adverse Events as Measured by NCI-CTCAE criteria measure: Incidence of Treatment-Emergent Adverse Events as Measured by Clinical Laboratory Measurements According to Established Clinical Normal Ranges measure: Incidence of Treatment-Emergent Adverse Events as Measured by ECG measure: Incidence of Treatment-Emergent Adverse Events as Measured by physical examination and vital signs measure: Incidence of Treatment-Emergent Adverse Events as Measured by central nervous system (CNS) and autonomic nervous system (ANS) examination. measure: PK parameter: Maximum drug concentration in plasma (Cmax) of SUL-238 after a single ascending dose (Part 1 and Part 2). measure: PK parameter: Maximum drug concentration in plasma (Cmax) of SUL-238 after multiple ascending doses (Part 3). measure: PK parameter: Area under the concentration-time curve in plasma (AUC) of SUL-238 after single ascending dose (Part 1 and Part 2). measure: PK parameter: Area under the concentration-time curve in plasma (AUC) of SUL-238 after multiple ascending doses (Part 3). measure: Renal clearance and percentage of drug excreted in urine after single and multiple ascending doses of SUL-238. measure: Percentage of drug excreted in feces after multiple ascending doses of SUL-238. measure: The cerebrospinal fluid (CSF) levels of SUL-238 sex: ALL minimumAge: 40 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Erciyes University IKUM Center status: RECRUITING city: Kayseri zip: 38030 country: Turkey name: Zafer Sezer, MD role: CONTACT phone: +903522076666 phoneExt: 24405 email: drzafersezer@gmail.com lat: 38.73222 lon: 35.48528 hasResults: False
nctId: NCT06277479 id: Rigshospitalet. Hematology briefTitle: Late Effects and HRQoL in Survivors of Allo-HSCT - a Cross Sectional Study overallStatus: ENROLLING_BY_INVITATION date: 2024-03 date: 2024-09 date: 2024-09 date: 2024-02-26 date: 2024-02-29 name: Rigshospitalet, Denmark class: OTHER name: Danish Cancer Society briefSummary: The cross-sectional study aims to describe the burden of late effects and survivorship-specific health-related quality of life in a nationwide cohort of patients treated with allo-HSCT in Denmark. Further, identify demographic, medical or personal factors associated with better self-reported health and quality of life. conditions: Hematological Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 1600 type: ESTIMATED measure: EORTC Quality of Life Survivorship Core questionnaire (EORTC-QOL-SURV100) measure: Health literacy Questionnaire (HLQ) measure: Modified 7-day Lee Chronic-versus-Host Disease Symptom Scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mette Schaufuss Engedal city: Copenhagen zip: 2100 country: Denmark lat: 55.67594 lon: 12.56553 hasResults: False
nctId: NCT06277466 id: XYFY2023-KL478-01 briefTitle: Effect of Mutations in T2DM Susceptibility Genes on the Expression of Susceptibility Genes in Patients With T2DM and Controls overallStatus: RECRUITING date: 2024-01-01 date: 2028-01-31 date: 2028-01-31 date: 2024-02-26 date: 2024-02-28 name: The Affiliated Hospital of Xuzhou Medical University class: OTHER briefSummary: In this study, investigators wanted to determine the effect of T2DM susceptibility gene mutations on self-expression.