hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06352359 id: ONC-841-002 briefTitle: Safety, Pharmacokinetics (PK), and Efficacy of ONC 841 in Advanced Solid Tumors overallStatus: NOT_YET_RECRUITING date: 2024-06-30 date: 2025-06-30 date: 2027-06-30 date: 2024-04-08 date: 2024-04-10 name: OncoC4, Inc. class: INDUSTRY briefSummary: This is a Phase I open label, dose-escalation study of intravenous (IV) infusion of ONC-841 as a single agent in patients with advanced/metastatic solid tumors. The study will evaluate seven dose levels of ONC-841 starting from 0.03 mg/kg to 30 mg/kg. conditions: Advanced Solid Tumor studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: ONC-841 measure: Dose Limiting Toxicity (DLT) measure: Maximum Toxicity Dose (MTD) measure: Cmax of ONC-841 measure: The serum half-life of ONC-841 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of California at Davis Cancer Center city: Sacramento state: California zip: 95817 country: United States name: Tianhong Li, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 38.58157 lon: -121.4944 facility: Norton Cancer Center city: Louisville state: Kentucky zip: 40202 country: United States name: John Hamm, MD role: PRINCIPAL_INVESTIGATOR lat: 38.25424 lon: -85.75941 facility: Tranquil Clinical Research city: Houston state: Texas zip: 77598 country: United States name: John Knecht, MD role: PRINCIPAL_INVESTIGATOR lat: 29.76328 lon: -95.36327 hasResults: False
Phase A acts as a control and is therefore compared with phase B. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The target behavior (i.e. performance on an untrained shopping task) will be measured repeatedly, on a minimum of six occasions in each phase where possible, in accordance with the recommendations of the What Works Clearinghouse and RoBiNT criteria. Repeated measures of target behavior will be assessed via the OxMET-NL task and is scored automatically: no assessor input is required to either save or score the main outcome data. The secondary outcome measure(s) are scored by an outcome assessor who is blind to the order in which the secondary outcome measure(s) were taken. whoMasked: OUTCOMES_ASSESSOR count: 4 type: ESTIMATED name: Compensatory brain game supporting Goal Management Training intervention measure: Change in performance on the Oxford Multiple Errands Test- Dutch version (OxMET-NL) from phase A to phase B measure: Change on the Visual Analogue Scale (VAS) from phase A to phase B to follow-up measure: Change in performance on treatment goals as measured with the Goal Attainment Scale (GAS) measure: Change in performance on two trained IADL task (treatment goals) measure: Change in everyday difficulties in activities/participation as measured on the Daily Living Questionnaire (DLQ-R-NL) measure: Change in strategy use during the performance of trained and untrained IADL tasks measure: Change in subjective experience of strategy use in daily life measure: Change in subjectively experienced psychological symptoms such as depressive, anxiety and stress symptoms. sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ProPersona city: Wolfheze state: Gelderland zip: 6874 BE Wolfheze country: Netherlands name: Bea Tiemens, PhD role: CONTACT email: b.tiemens@propersona.nl name: Floor Poerschke, MSc role: SUB_INVESTIGATOR name: Emily Vink, MSc role: SUB_INVESTIGATOR lat: 52.00333 lon: 5.79028 hasResults: False
nctId: NCT06352333 id: Parasagittal Vs Cornerpocket briefTitle: Parasagittal Vs Cornerpocket Approaches overallStatus: NOT_YET_RECRUITING date: 2024-04-02 date: 2024-11-01 date: 2025-01-01 date: 2024-04-08 date: 2024-04-08 name: Sohag University class: OTHER briefSummary: Brachial plexus blocks are widely used to provide anesthesia for upper limb surgery.
A new Parasagittal approach for brachial plexus block at the supraclavicular level was studied by Adrian Searle where the arc of the first rib was used to provide a deep limit to needle transit in order to minimize the risk of pneumothorax ;the aim of our study is to further evaluate the parasagittal approach for brachial plexus block and compare it with the popular corner pocket approach conditions: Supraclavicular Brachial Plexus Block studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Inclusion criteria:
* Elective upper limb surgery primaryPurpose: SCREENING masking: NONE count: 80 type: ESTIMATED name: supraclavicular ultrasound guided brachial plexus block measure: Needle visibility in both approaches measure: Duration of sensory and motor block measure: Success rate measure: Complications sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Sohag university Hospital city: Sohag country: Egypt name: Magdy M Amin, professor role: CONTACT lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06352320 id: XJTU1AF2023LSK-533 briefTitle: Risk Stratification and New Early Prevention and Treatment Strategies for Patients With Cardiomyopathy (STRENGTH） overallStatus: NOT_YET_RECRUITING date: 2024-12-31 date: 2030-08-31 date: 2032-08-31 date: 2024-04-08 date: 2024-04-08 name: First Affiliated Hospital Xi'an Jiaotong University class: OTHER briefSummary: This study will include patients with different types of cardiomyopathy from multiple centers were prospectively enrolled in a retrospective study to establish a natural population cohort of cardiomyopathy patients. By collecting clinical data and biological samples from surgical patients, we will construct a prognostic system for cardiomyopathy, optimize risk stratification, explore new strategies for the early prevention and treatment of cardiomyopathy, and improve the efficiency of clinical cardiomyopathy patients' diagnosis and treatment. conditions: Cardiomyopathies studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 500 type: ESTIMATED name: Diagnosis of HCM name: Diagnosis of DCM name: Diagnosis of ARVC name: Diagnosis of NDLVC name: Diagnosis of RCM name: Diagnosis of LVNC measure: Change in the incidence of mortality rate sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: First Affiliated Hospital of Xi'an Jiantong University city: Xi'an state: Shaanxi zip: 710061 country: China lat: 34.25833 lon: 108.92861 hasResults: False
nctId: NCT06352307 id: XJTU1AF2023LSK-532 briefTitle: Risk Stratification, Early Prevention and Treatment Strategies for Arrhythmogenic Cardiomyopathy acronym: STARTER overallStatus: NOT_YET_RECRUITING date: 2024-12-31 date: 2030-08-31 date: 2032-08-31 date: 2024-04-08 date: 2024-04-08 name: First Affiliated Hospital Xi'an Jiaotong University class: OTHER briefSummary: This study will include patients diagnosed with Arrhythmogenic cardiomyopathy (ACM) in the First Affiliated Hospital of Xi 'an Jiaotong University and other centers, and collect clinical data and biological samples of patients with different ACM phenotypes. Through the establishment of disease cohort and long-term follow-up, to explore the disease characteristics, development law, clinical characteristics, natural course of disease and long-term prognosis of ACM. conditions: Arrhythmogenic Cardiomyopathy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 1500 type: ESTIMATED name: Diagnosis of ACM measure: Change in the incidence of mortality rate sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: First Affiliated Hospital of Xi'an Jiantong University city: Xi'an state: Shaanxi zip: 710061 country: China name: Guoliang Li role: CONTACT phone: 008613759982523 email: liguoliang_med@163.com name: Yang Yan role: CONTACT phone: +86.29.85323869 email: yangyan3@xjtu.edu.cn lat: 34.25833 lon: 108.92861 hasResults: False
nctId: NCT06352294 id: MSDALAKCI briefTitle: The Effects of Myofascial Relaxation Technique Applied Together With Core Stabilization Trainings on Balance, Pain, Joint Range of Motion and Functionality in Individuals With Chronic Neck Pain overallStatus: RECRUITING date: 2024-03-29 date: 2024-07 date: 2024-07 date: 2024-04-08 date: 2024-04-08 name: Kirsehir Ahi Evran Universitesi class: OTHER briefSummary: Chronic neck pain is a musculoskeletal disorder that affects people frequently in life. Nov.
The study included 45 people between the ages of 18 and 65 Dec. In two groups, the core stabilization group will be 22 people, and the core stabilization and myofascial relaxation group will be 23 people. The study period is planned as 6 weeks and 3 sessions per week. conditions: Neck Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 45 type: ESTIMATED name: Core stability training name: Core stability training and myofascial relase measure: Pain severity measure: Pressure pain threshold (PPT) measure: Balance measure: Range of motion measure: Neck Disability İndex measure: DASH sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kırşehir Ahi Evran Üniversitesi status: RECRUITING city: Merkez state: Kırşehir country: Turkey name: Muhammed Samed Dalakçı role: CONTACT phone: 905445325572 email: samed.dalakci@gmail.com hasResults: False
nctId: NCT06352281 id: KM-007 briefTitle: Efficacy and Safety of CAR-T Cells Therepy for Chronic or Refractory Primary Immune Thrombocytopenia (ITP) overallStatus: RECRUITING date: 2024-02-01 date: 2026-01-01 date: 2027-12-31 date: 2024-04-08 date: 2024-04-08 name: 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China class: OTHER briefSummary: It is a single-center, single-arm, open-labeled clinical trial to evaluate the efficacy and safety of CAR-T cells therapy for Chronic or Refractory Primary Immune Thrombocytopenia (ITP). conditions: ITP - Immune Thrombocytopenia studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: CAR-T cells measure: Portion of patients with response (R) measure: Portion of patients with complete response (CR) measure: Portion of patients with relapse measure: Time (in days) from treatment start to response (R) measure: Time (in days) from treatment to complete response (CR) measure: Duration (in days) of response (R) measure: Incidence of adverse events(AE) after infusion sex: ALL minimumAge: 8 Years maximumAge: 75 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China status: RECRUITING city: Kunming state: Yunnan zip: 650000 country: China name: Wang Sanbin, Doctor role: CONTACT phone: 13187424131 phoneExt: +86 email: sanbin1011@163.com lat: 25.03889 lon: 102.71833 hasResults: False
nctId: NCT06352268 id: IEC-368/17.07.2023 briefTitle: Lesioning Procedures for Movement Disorders overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2027-12-31 date: 2028-12-31 date: 2024-04-08 date: 2024-04-08 name: All India Institute of Medical Sciences, New Delhi class: OTHER briefSummary: Dystonia is a rare syndrome with varying etiologies. Similarly, tremor conditions refractory to medical management and disabling that they need surgical interventions are rare in our setting. So far there are no randomized controlled trials of pallidotomy for management of dystonia. There is scant literature on the long term efficacy and safety of Pallidotomy, thalamotomy and other such lesioning procedures in the management of movement disorders. The current literature is significantly plagued by publication bias as case reports with successful outcomes are likely to be selectively published in journals or conference abstracts. Lesioning procedures though seem to be effective are often considered to be risky, especially bilateral pallidotomy is not preferred by several centres. However, our center routinely performs simultaneous bilateral pallidotomy. To generate long term data on the efficacy and safety of lesioning procedures in rare diseases like dystonias especially the effect of functional neurosurgery on varying etiologies of the disease, robust registries are required which collect data on all consecutive patients who undergo the procedure. conditions: Dystonia conditions: Parkinson Disease conditions: Essential Tremor studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 250 type: ESTIMATED name: Pallidal, subthalamic or thalamic lesioning measure: Long term functional outcomes measure: Long term functional outcomes measure: Predictors of outcomes measure: Demography measure: Clinical features measure: Laboratory findings measure: Imaging features measure: Treatment trends measure: Clinical features measure: Treatment trends sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: All India Institute of Medical Sciences, New Delhi city: New Delhi state: Delhi zip: 110029 country: India name: Arunmozhimaran Elavarasi, MD DM role: CONTACT phone: +919013844274 email: arun_ela@yahoo.com lat: 28.63576 lon: 77.22445 hasResults: False
nctId: NCT06352255 id: AR1937 briefTitle: Pain and Anxiety During Local Block overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2024-12 date: 2025-07 date: 2024-04-08 date: 2024-04-08 name: University of Seville class: OTHER briefSummary: INTRODUCTION: Currently, there is no scientific evidence about pain in the anesthetic blockage of the first finger according to the application method. However, clinical evidence has valued the use of carpule, due to the low pain it generates in the patient to the application of anesthetic. Most studies on anesthesia and pain, especially with the use of carpule and distracting methods, belong to the field of dentistry.
Result: after the completion of the study CONCLUSIONS: After the completion of the study conditions: Anesthesia, Local conditions: Pain conditions: Anxiety studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 200 type: ESTIMATED name: Digital block measure: Grade of Pain postinyection measure: Anxiety before the intervention sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06352242 id: RECHMPL24-0076 UF 9572 briefTitle: Is Trogocytosis a Predictive Marker of CAR-T Cell Response in Diffuse Large B-cell Lymphoma? acronym: CARTROG overallStatus: NOT_YET_RECRUITING date: 2024-04-08 date: 2026-04-08 date: 2026-04-08 date: 2024-04-08 date: 2024-04-08 name: University Hospital, Montpellier class: OTHER briefSummary: CAR-T cell therapy has improved survival in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL R/R). However, only 65% of patients achieve a complete metabolic response after this treatment. To date, there is no predictive test for therapeutic response after injection of CAR-T cells. Recent studies have shown that the level of trogocytosis by immune cells correlates with the persistence of tumor cells in patients with hematological malignancies. Our main objective is to identify a phenotypic "signature" of trogocytosis predictive of therapeutic response 6 months after injection of CAR-T cells for DLBCL. conditions: Diffuse Large B Cell Lymphoma studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 85 type: ESTIMATED name: Flow cytometry analysis to determine the level of trogocytosis by effector immune cells in patients name: Flow cytometry analysis to determine the level of trogocytosis by effector immune cells in volunteers measure: Identification of a phenotypic "signature" of trogocytosis predictive of failure to achieve a complete metabolic response for patients with diffuse large B-cell lymphoma. measure: Identification of a phenotypic "signature" of trogocytosis predictive of the occurrence of grade II or more immunological adverse events measure: Identification of a phenotypic "signature" of trogocytosis predictive of the occurrence of serious hematological side effects. measure: Determination of the trogocytosis level of normal lymphocytes and NK cells in healthy subjects sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06352229 id: 514-0335/23-2000 briefTitle: The Playful Learning in Infancy Program acronym: PLIP overallStatus: RECRUITING date: 2023-06-01 date: 2026-11-30 date: 2026-11-30 date: 2024-04-08 date: 2024-04-08 name: University of Copenhagen class: OTHER name: LEGO Foundation briefSummary: In the Playful Learning in Infancy Program, parents receive research-based educational guidance on playful interactions with their infants aged 0-1 year. They learn to recognize their infants' cues indicating readiness to engage in play and they are introduced to specific, developmentally appropriate activities for interactive engagement. The guidance is delivered to parents during routine home visits by public health visitors.
Evaluation is based on a parallel group study design, with half of the participants receiving care as usual and half of the participants receiving care as usual along with the Playful Learning in Infancy Program. conditions: Parent-Child Relations conditions: Infant Development studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Evaluation is based on a parallel group study, with half of the participants receiving care as usual and half of the participants receiving care as usual along with the Playful Learning in Infancy Program. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 2327 type: ESTIMATED name: Playful Learning in Infancy Program name: Postnatal care as usual measure: Parental Playful interactions measure: Parental Stress measure: Infant Socio-emotional Development measure: Infant Level of Play measure: Parental Mind-Mindedness measure: Parental Attachment Style measure: Parental Mental Well-Being measure: Infant Screen Time measure: Questions developed for the study regarding Parental Involvement measure: Questions developed for the study regarding Parental Knowledge of Play measure: Parental Experience of the PLIP measure: Health Visitors' Experience of the PLIP sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Center for Early Interventions and Family Studies, Department of Psychology, University of Copenhagen status: RECRUITING city: Copenhagen zip: 1353 country: Denmark name: Mette S. Væver, PhD role: CONTACT phone: +45 35324906 email: mette.vaever@psy.ku.dk name: Maja Nyström-Hansen, PhD role: CONTACT phone: +4535336499 email: mnh@psy.ku.dk lat: 55.67594 lon: 12.56553 hasResults: False
nctId: NCT06352216 id: Elo-Ger-2023-1642 briefTitle: Prevalence of Synovitis in Patients With Haemophilia A acronym: SynoPrev overallStatus: RECRUITING date: 2024-04-15 date: 2027-02 date: 2027-03 date: 2024-04-08 date: 2024-04-16 name: University Hospital, Bonn class: OTHER name: Swedish Orphan Biovitrum briefSummary: The aim of this study is to evaluate the prevalence of synovitis in adult patients with haemophilia A. conditions: Haemophilia A conditions: Synovitis conditions: Hemophilia Arthropathy conditions: Sonography studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 300 type: ESTIMATED name: Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US); Haemophilia joint health score (HJHS) measure: Haemophilia early arthropathy detection with ultrasound (HEAD-US) measure: The Hemophilia Joint Health Score version 2.1 (HJHS) measure: PROMIS-29 Questionaire measure: Haemophilia Activities List (HAL) measure: Baseline Characteristics sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Bonn status: RECRUITING city: Bonn state: NRW zip: 53113 country: Germany name: Andreas C. Strauss, PD Dr. med. role: CONTACT phone: 004922828714176 email: andreas.strauss@ukbonn.de name: Andreas C. Strauss, PD Dr. med. role: PRINCIPAL_INVESTIGATOR lat: 50.73438 lon: 7.09549 hasResults: False
nctId: NCT06352203 id: AUT/23.02 briefTitle: Effect of Probiotics on the Intestinal Microbiota of Pediatric Patients overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-09 date: 2025-11 date: 2024-04-08 date: 2024-04-08 name: ProbiSearch SL class: INDUSTRY briefSummary: Numerous studies have described an altered gut microbiota composition (dysbiosis) in patients with neurodevelopmental disorders that can be correlated with their symptoms, especially gastrointestinal symptoms.
Participants will be randomly assigned to one of the two study groups: control group with placebo administration or probiotic administration group. conditions: Neurodevelopmental Disorders studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: Probiotic name: Placebo measure: Number of children with intestinal dysbiosis after 6 months of treatment. sex: ALL minimumAge: 3 Years maximumAge: 7 Years stdAges: CHILD hasResults: False
nctId: NCT06352190 id: SY-5007-I-04 briefTitle: A Study to Evaluate the Mass Balance of [14C] SY-5007 in Healthy Adult Male Subjects in China overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-06-01 date: 2024-06-01 date: 2024-04-08 date: 2024-04-08 name: Shouyao Holdings (Beijing) Co. LTD class: OTHER briefSummary: This is a single-center, open-label, non-randomized, single dose study in healthy male subjects designed to assess mass balance recovery, metabolite profile and metabolite identification of radio-labeled SY-5007 administered orally. conditions: Healthy Subjects studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 8 type: ESTIMATED name: [14C] SY-5007 measure: Total radioactivity in plasma PK: Cmax measure: Total radioactivity in plasma PK: Tmax measure: Total radioactivity in plasma PK: AUC0-t measure: Total radioactivity in plasma PK: t½ measure: Total radioactivity in plasma PK: CL/F measure: Whole blood to plasma total radioactivity ratio measure: Cumulative total radioactivity in urine and faeces measure: Metabolic profiling in plasma, urinary and fecal excretion measure: Cmax of SY-5007 and its metabolites measure: Tmax of SY-5007 and its metabolites measure: AUC0-t of SY-5007 and its metabolites measure: t½ of SY-5007 and its metabolites measure: CL/F of SY-5007 and its metabolites measure: Incidence of adverse events sex: MALE minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Beijing Friendship Hospital, Capital Medical University city: Beijing zip: 100050 country: China name: Ruihua Dong, MD role: CONTACT phone: 86-010-63139033 email: ruihua_dong_rw@163.com lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06352177 id: protocol-1 briefTitle: Digital Therapeutic Lifestyle Intervention Program for Patients With MASLD acronym: ENLIGHTEN overallStatus: NOT_YET_RECRUITING date: 2025-04-01 date: 2029-12-31 date: 2030-08-01 date: 2024-04-08 date: 2024-04-08 name: Milton S. Hershey Medical Center class: OTHER briefSummary: The ENLIGHTEN study that will evaluate the efficacy of a novel DTx lifestyle intervention in participants with non-cirrhotic MASH. People who have MASH, the progressive subtype of MASLD, have the highest risk for liver disease progression and poor outcomes, including cirrhosis and hepatocellular carcinoma, and greater overall mortality. Thus, these participants are expected to experience the greatest benefit from treatment.