nctId: NCT06290505 id: PALEO briefTitle: A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study acronym: PALEO overallStatus: RECRUITING date: 2021-12-08 date: 2027-07-31 date: 2028-01-31 date: 2024-03-04 date: 2024-03-04 name: Australasian Gastro-Intestinal Trials Group class: NETWORK briefSummary: The purpose of this study is to investigate the effects of the addition of the stereotactic body radiotherapy and durvalumab to a well tolerated 2 week chemotherapy and radiation treatment regimen in people with oesophageal cancer that has spread to another are of the body (metastasised). conditions: Oesophageal Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 54 type: ESTIMATED name: Durvalumab measure: Progression free survival rate is the proportion of patients alive and progression free (the cancer has not worsened) assessed by CT Scan and clinical review. measure: Duration of dysphagia relief measure: Nutritional status measure: Quality of life change using the - European organisation for the research and treatment of cancer quality of life questionnaire QLQ-C30 measure: Quality of life change using the - European organisation for the research and treatment of cancer quality of life questionnaire QLQ-OES18 measure: Response rate in metastatic lesions measure: Physician graded toxicity measure: SAE Rate measure: Overall survival. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Border Medical Oncology status: RECRUITING city: Albury state: New South Wales zip: 2640 country: Australia name: Jacqui McBurnie role: CONTACT email: jacqui.mcburnie@bordermedonc.com.au lat: -36.07482 lon: 146.92401 facility: Calvary Mater Newcastle status: RECRUITING city: Newcastle state: New South Wales zip: 2298 country: Australia name: Kim Adler role: CONTACT email: paleo@calvarymater.org.au lat: -32.92715 lon: 151.77647 facility: Royal Brisbane and Women's Hospital status: RECRUITING city: Herston state: Queensland zip: 4029 country: Australia name: Jacqui Keller role: CONTACT email: jacqui.keller@health.qld.gov.au lat: -27.44453 lon: 153.01852 facility: Flinders Medical Centre status: RECRUITING city: Bedford Park state: South Australia country: Australia name: Aleksandra Kuruni, Dr role: CONTACT email: Aleksandra.Kuruni@sa.gov.au lat: -35.03333 lon: 138.56667 facility: St Vincent's Hospital status: RECRUITING city: Fitzroy state: Victoria zip: 3065 country: Australia name: Nadia Ranieri role: CONTACT email: Nadia.RANIERI@svha.org.au lat: -37.79839 lon: 144.97833 facility: Peter MacCallum Cancer Centre status: RECRUITING city: Melbourne state: Victoria zip: 3000 country: Australia name: Shandelle Norman role: CONTACT email: Shandelle.Norman@ctaust.org lat: -37.814 lon: 144.96332 facility: Sir Charles Gairdner Hospital status: RECRUITING city: Nedlands state: Western Australia zip: 6009 country: Australia name: Aylin Yahya role: CONTACT email: Aylin.Yahya@health.wa.gov.au lat: -31.98184 lon: 115.8073 facility: Auckland Hospital status: RECRUITING city: Grafton state: Auckland zip: 1023 country: New Zealand name: Sophie Goodger role: CONTACT email: SophieGo@adhb.govt.nz lat: -36.86029 lon: 174.76566 hasResults: False