hackint0sh/New-Dataset huggingface dataset:
There are no major risks associated with this study. conditions: Insomnia studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Participants will complete a 5-week study consisting of screening assessments, baseline scales and surveys, objective digital measure, 2 weeks of product use (1 week on - 1 week off - 1 week on), scales and surveys, and end of study assessments and surveys. This is a remote observational study that will use the People Science app-based data collection platform Consumer Health Learning and Organizing Ecosystem (CHLOE) for study participants to report their assessments and collect objective sleep data from personal wearable devices. Participants will receive the study product during the baseline period. Demographic and medical history data will be collected for the study. primaryPurpose: TREATMENT masking: NONE maskingDescription: This study is not blinded. Participants consume the intervention on alternating weeks. All participants receive the intervention count: 77 type: ACTUAL name: Sip2Sleep: Montmorency Cherry and Apocynum Venetum measure: Subjective Sleep Quality measure: Insomnia Sleep Index measure: Generalized Anxiety Disorder-7 (GAD-7) measure: Subjective Alertness measure: Exploratory: Sleep Duration measure: Exploratory: Sleep Latency measure: Participant Satisfaction sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: People Science Inc. city: West Hollywood state: California zip: 90069 country: United States lat: 34.09001 lon: -118.36174 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-03-24 uploadDate: 2024-02-28T17:22 filename: Prot_SAP_000.pdf size: 436932 hasResults: False
nctId: NCT06299475 id: 2023-06755-01 briefTitle: Structured Online Contraceptive Counseling (LOWE Trial) at Emergency Contraception (EC) Pharmacy Provision LOWE+EC=LOWEC acronym: LOWEC overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-07 date: 2026-09 date: 2024-03-07 date: 2024-03-07 name: Karolinska Institutet class: OTHER name: the Swedish Pharmacy Association briefSummary: To increase sexual and reproductive health and rights through the improvement of contraceptive counseling and easy access to service and, thus, women's use of effective contraceptives after purchase of an emergency contraceptive pill (ECP). conditions: Contraception studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: A cluster randomized crossover trial primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 600 type: ESTIMATED name: Online counseling and invitation measure: Use of effective contraception measure: Contraceptive use measure: Incidence of pregnancy and abortion measure: Satisfaction with the intervention measure: Contraceptive use, pregnancy, abortion and satisfaction in vulnerable groups measure: Process evaluation sex: FEMALE minimumAge: 15 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06299462 id: PTCy-ATG-001 briefTitle: PTCy and ATG for MSD and MUD Transplants overallStatus: NOT_YET_RECRUITING date: 2024-05-21 date: 2031-06-01 date: 2031-06-01 date: 2024-03-07 date: 2024-03-07 name: Instituto Nacional de Cancer, Brazil class: OTHER_GOV briefSummary: Hematopoietic stem cell transplantation is a curative treatment for a number of benign and malignant hematologic diseases. One of the key parts of hematopoietic stem cell transplantation is the prophylaxis of graft-versus-host disease. Since the end of the 1970s, with the introduction of cyclosporine, calcineurin inhibitors (cyclosporine and tacrolimus) have become part of almost all prophylactic regimens, even though they are a group of drugs with a poor toxicity profile that requires monitoring. constant serum level. Since 2008, post-transplant cyclophosphamide has been introduced with great success, associated with a calcineurin inhibitor and mycophenolate, in the prophylaxis of graft-versus-host disease in haploidentical transplantation (50% matched).
Graft-versus-host disease prophylaxis will be performed on D+3 and D+4 with cyclophosphamide and with ATG on D-1 or on D-2 and D-1, depending on ATG de-escalation, for matched-sibling transplants, according to prespecified criteria based on the 3+3 approach; and on D+3 and D+4 with cyclophosphamide and with ATG on D-2 and D-1, for unrelated donors. conditions: Acute Myeloid Leukemia conditions: Acute Lymphoblastic Leukemia conditions: Myelodysplastic Syndromes conditions: Hodgkin Lymphoma conditions: Non-hodgkin Lymphoma studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients with a matched sibling donor will be assigned to the PTCy+ATG2.5±1.5 arm, while patients with an matched unrelated donor will be assigned to the PTCy+ATG5.0 arm primaryPurpose: PREVENTION masking: NONE count: 50 type: ESTIMATED name: ATG 5.0 name: Cyclophosphamide injection name: ATG 2.5±1.5 measure: Cumulative incidence of grades III-IV acute GVHD by the MAGIC criteria measure: Cumulative incidence of grades II-IV acute GVHD by the MAGIC criteria measure: Cumulative incidence of steroid-refractory acute GVHD as defined by Mohty et al PMID 32756949 measure: Cumulative incidence of chronic GVHD as defined by the NIH criteria measure: Cumulative incidence of steroid-requiring chronic GVHD as defined by the NIH criteria measure: Cumulative incidence of non-relapse mortality, i.e., death not following disease relapse measure: Cumulative incidence of relapse, defined as > 5% blasts in bone marrow or 1% blasts in peripheral blood (acute leukemias/myelodysplasia) or biopsy proven relapse or positve PET-CT (lymphoma) measure: Rate of overall survival measure: Rate of disease-free survival (death or relapse) measure: Cumulative incidence of clinically significant CMV reactivation (which led to antiviral treatment) measure: Cumulative incidence of posttransplant lymphoproliferative disorder (biopsy-proven or positive EBV PCR combined with clinical symptoms) measure: Cumulative incidence CMV disease (biopsy-proven CMV disease OR suggestive CMV+ BAL) measure: Measuremnt of quality of life using the FACT-BMT scale sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-03-23 uploadDate: 2023-03-23T15:38 filename: Prot_SAP_000.pdf size: 322979 hasResults: False
nctId: NCT06299449 id: KFSIRB200-174 briefTitle: Artificial Intelligence Assisted Socket Shield With Computer Guided Implant Placement overallStatus: RECRUITING date: 2024-03-05 date: 2025-03-15 date: 2025-03-20 date: 2024-03-07 date: 2024-03-12 name: Kafrelsheikh University class: OTHER briefSummary: Aim of the current randomized clinical trial is to evaluate and compare the effectiveness of computer-guided immediate implant placement performed simultaneously with artificial intelligence assisted socket shield technique versus conventional approach. conditions: Implant Complication conditions: Dental Implant Failed studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 46 type: ESTIMATED name: free-hand socket shield name: AI/guided socket shield measure: Stability Quotient of dental implant measure: pink esthetic score measure: Midfacial Mucosal Alterations measure: facial marginal bone level sex: ALL minimumAge: 19 Years maximumAge: 40 Years stdAges: ADULT facility: faculty of dentistry, kafrelsheikh University status: RECRUITING city: Kafr Ash Shaykh state: Kafrelsheikh zip: 214312 country: Egypt name: walid elamrousy role: CONTACT phone: +201005724781 email: Waled_Hammed@den.kfs.edu.eg lat: 31.11174 lon: 30.93991 hasResults: False
nctId: NCT06299436 id: IRB00426760 id: R01HL172830 type: OTHER domain: NHLBI/NIH briefTitle: Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure acronym: HALT-RHF overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2029-03-31 date: 2029-03-31 date: 2024-03-07 date: 2024-03-07 name: Johns Hopkins University class: OTHER name: National Heart, Lung, and Blood Institute (NHLBI) briefSummary: Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best clinical indicators of intrinsic RV myocyte contractile failure in humans with HFrEF-PH, (2) clarify underlying mechanisms, and (3) test novel treatments on RV myocytes. The long-term goal of this proposal will be to better identify and treat RV failure in humans suffering from HFrEF-PH. conditions: Heart Failure With Reduced Ejection Fraction conditions: Pulmonary Hypertension conditions: Right Heart Failure Due to Left Heart Failure studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED measure: Diagnostic accuracy based on Area Under Curve (AUC) measure: Percentage improvement in ex vivo right ventricular tissue sample measure: Predictive capacity (based on likelihood ratio) sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06299423 id: 3677 briefTitle: Perioperative Monitoring to Assess Preoperative Anxiety in Inflammatory Bowel Disease Patients acronym: PeRseo overallStatus: RECRUITING date: 2023-11-22 date: 2025-06-30 date: 2025-11-30 date: 2024-03-07 date: 2024-03-08 name: Istituto Clinico Humanitas class: OTHER briefSummary: Anxiety and depression are extremely common among Inflammatory Bowel Disease (IBD) patients undergoing surgery and may increase the risk of postoperative adverse outcomes. This study aims to objectively evaluate preoperative psychological distress by remotely measuring the patient's physiological parameters and Heart Rate Variability (HRV) with the Howdy Senior ® device (Comftech Srl). Additionally, the study will also investigate the feasibility and effectiveness of the Howdy Senior® device in improving the postoperative patient's monitoring. conditions: Inflammatory Bowel Diseases conditions: Surgery studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: Single-center, interventional, case-series study with a historical cohort of comparison primaryPurpose: PREVENTION masking: NONE count: 80 type: ESTIMATED name: Howdy Senior® device measure: Correlation between preoperative anxiety and preoperative Heart Rate Variability (HRV) measure: Correlation between preoperative anxiety and 90-day Comprehensive Complication Index (CCI) measure: Correlation between preoperative anxiety and preoperative Patient Health Engagement Scale (PHE-S) measure: Correlation between preoperative anxiety and C-Reactive Protein (CRP) level 24 hour after surgery measure: 90-day postoperative complications measure: Correlation between the 90-day Postoperative Recovery Profile (PRP) and 90-day Heart Rate Variability (HRV) measure: Healthcare costs sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Humanitas Research Hospital status: RECRUITING city: Rozzano state: MI zip: 20089 country: Italy name: Annalisa Maroli, PhD role: CONTACT phone: 02 8224 7776 phoneExt: 0039 email: colorapp@humanitas.it lat: 45.38193 lon: 9.1559 hasResults: False
nctId: NCT06299410 id: ITI-1284-008 briefTitle: PET Study to Evaluate Brain Receptor Occupancy, Safety and Pharmacokinetics of ITI-1284 in Healthy Subjects overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-03 date: 2025-03 date: 2024-03-07 date: 2024-03-07 name: Intra-Cellular Therapies, Inc. class: INDUSTRY briefSummary: The study will be conducted as an open-label and single-center study to evaluate the occupancy of ITI-1284 to the dopamine D2 receptor in healthy subjects. Subjects will enroll in one of the 2 cohorts, will have a baseline PET/CT scan, will receive a single dose of ITI-1284, and undergo one postdose PET/CT scan. conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: ITI-1284 10 mg name: ITI-1284 20 mg measure: % Receptor occupancy measure: Pharmacokinetics: AUC0-t measure: Pharmacokinetics: Cmax measure: Pharmacokinetics: Tmax measure: Percentage of subjects with treatment-emergent adverse events measure: Change from baseline in ECG QT interval measure: Change from baseline in aspartate aminotransferase measure: Change from baseline in alanine aminotransferase sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Clinical Site 1 city: New Haven state: Connecticut zip: 06520 country: United States lat: 41.30815 lon: -72.92816 hasResults: False
nctId: NCT06299397 id: Inonu-SBF-4 briefTitle: Breastfeeding Education and Humor-Based Practices on Breastfeeding overallStatus: COMPLETED date: 2023-06-14 date: 2023-07-14 date: 2024-02-14 date: 2024-03-07 date: 2024-03-12 name: Inonu University class: OTHER briefSummary: The aim of this study is to determine the effect of breastfeeding education and humor-based practices in the antenatal period on breastfeeding motivation and attachment. 32-36 patients who applied to Bartın Gynecology and Children's Hospital for the project. It will consist of 64 pregnant women (32 experimental and 32 control group) at gestational week. Pregnant women who agree to participate in the project between these months will receive 30-45 minutes of humor practice after 30 minutes of breastfeeding training in the first session. The education and humor application will be implemented again a week later, on the same day, at the same time and in the same place. In the humor application, dance performances, applause, singing and laughter accompanied by 5 songs determined by the researchers will be included. The training program prepared for breastfeeding education will be applied to pregnant women. Then, humor will be applied. A pre-test will be administered before the training, a mid-test 1 month after the training, and a post-test in the 3rd month. Project data will be collected using the 'Introductory Information Form', 'Breastfeeding Motivation Scale' and 'Maternal Attachment Scale'. conditions: Humor as Topic conditions: Breast Feeding conditions: Mother-Child Relations conditions: Breastfeeding, Exclusive studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants determined by the researchers before starting the study were divided into experimental and control groups by randomization method. Humor-based breastfeeding education was given to women in the experimental group for 35-45 minutes once a week for 2 weeks on specified days and hours. Breastfeeding education was given in practice. Then, humor was practiced with songs and clown costumes. An interim test was administered one month after this application and a final test was administered three months later. primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: After randomization was performed by a researcher independent of the study, it was decided by lottery method which group would be the experiment and which group would be the control group. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 64 type: ACTUAL name: breastfeeding - humor training name: Control Group measure: Breastfeeding Motivation Scale measure: Maternal Attachment Scale sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Simge OZTURK city: Bartin zip: 74100 country: Turkey lat: 41.63583 lon: 32.3375 hasResults: False
nctId: NCT06299384 id: R44MH133517 type: NIH link: https://reporter.nih.gov/quickSearch/R44MH133517 briefTitle: The Use of Voice-Based AI in 988 Crisis Counseling overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-06 date: 2026-08 date: 2024-03-07 date: 2024-03-07 name: Lyssn.io, Inc. class: INDUSTRY name: ProtoCall Services, Inc. briefSummary: Effective training requires repeated opportunities for skills practice with performance-based feedback, which is challenging to provide at scale. This research study focuses on developing an AI-based, coding and feedback tool ("LyssnCrisis") for implementation in a nationally utilized crisis call center, training counselors (call-takers) in suicide risk assessment skills, and evaluating LyssnCrisis to improve services and client outcomes. Our goal is to maximize the human capacity of call-takers to help assess their callers for risk of suicidality, and thus, a core aspect of the current research is developing a novel training process that supports human call-taker capacities. conditions: Suicide conditions: Suicide and Self-harm studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: NONE count: 100 type: ESTIMATED name: LyssnCrisis measure: Post-Call Survey measure: Call-taker crisis counseling fidelity measure: System Usability Scale (SUS) measure: Acceptability of Intervention Measure; AIM measure: Intervention Appropriateness Measure; IAM measure: Feasibility of Intervention Measure; FIM sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06299371 id: MA-NSCLC-II-033 briefTitle: Adebrelimab Plus Chemotherapy as Neoadjuvant Therapy in Resectable NSCLC Harboring Driver Gene Mutations overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-04-15 date: 2029-04-15 date: 2024-03-07 date: 2024-03-07 name: Liaoning Tumor Hospital & Institute class: OTHER briefSummary: This is a prospective, single-arm study to investigate the efficacy and safety of Adebrelimab in combination with paclitaxel for injection (albumin bound) and platinum chemotherapy as neoadjuvant therapy in resectable non-small cell lung cancer harboring driver gene mutations conditions: Non Small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 36 type: ESTIMATED name: Adebrelimab name: paclitaxel for injection (albumin bound) name: Cisplatin or Carboplatin measure: Pathological complete response rate measure: Major pathologic response rate measure: R0 rate measure: Event Free Survival measure: Overall Survival measure: Objective response rate measure: Adverse Events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06299358 id: KMU_MPEPE_1 briefTitle: Interventional Practices and Their Effectiveness in Infants With İnfantyl Colic overallStatus: ACTIVE_NOT_RECRUITING date: 2023-11-06 date: 2024-08-15 date: 2025-01-01 date: 2024-03-07 date: 2024-03-07 name: Karamanoğlu Mehmetbey University class: OTHER briefSummary: Infantile colic is a developmental disorder that reduces comfort levels in infants with intense crying crises and has negative effects on the infant and family. The study is planned to measure the effect of the combination of maternal heart sound simulation, aromatic foot massage and maternal heart sound simulation and aromatic foot massage on the colic and comfort levels of infants with infantile colic. It is aimed to alleviate colic symptoms, increase comfort levels, regulate daily crying and sleep durations (increase in sleep durations, decrease in crying durations) and support the development of infants in this context by using maternal heart sound simulation, aromatic foot massage and their combined application. conditions: Nurse's Role conditions: Infantile Colic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Type and Purpose of the Study The study was designed as a randomized experimental study. Sample of the Study G\* Power 3.1.9.7. program was used to calculate the sample size (Faul et al., 2007). As a result of the analysis, the sample size was calculated as 28 people for each of the three groups, and considering the possible data losses, it was decided to take 30 people for each group.
SPSS 22.0 package program will be used for data analysis. primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: In the study, interviews will be conducted at different times so that mothers or caregivers do not encounter mothers/caregivers in other groups. In this way, participant blinding will be ensured. Since the study will be conducted with newborns, no study will be conducted on other blinding techniques and biases. In order to prevent bias in the data evaluation process, each baby will be numbered by the researcher during the application and these numbers will be used by the statistical expert in statistical evaluations. The statistical expert will not learn the identity information of the participants and will only perform statistics according to the numbering. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: Foot massage name: Mother heart sound name: Foot massage and maternal heart sound measure: Changes in colic scale ratings induced by maternal heart sound measure: Changes in comfort scale ratings as a result of maternal heart sound measure: Changes in colic scale assessments induced by foot massage measure: Changes in comfort scale assessments induced by foot massage sex: ALL minimumAge: 2 Weeks maximumAge: 16 Weeks stdAges: CHILD facility: Karamanoglu Mehmetbey University city: Karaman state: Center zip: 70100 country: Turkey lat: 37.18111 lon: 33.215 hasResults: False
nctId: NCT06299345 id: 1870394-1 briefTitle: The Effect of Motor Imagery Dosage on Motor Learning in Healthy Adults overallStatus: COMPLETED date: 2022-03-01 date: 2022-04-20 date: 2022-04-28 date: 2024-03-07 date: 2024-03-12 name: Ahmed Mahmoud Kadry class: OTHER name: Concordia University Wisconsin briefSummary: The goal of this clinical trial is to compare the effects of different durations of Motor Imagery (MI) practice and physical practice on motor performance enhancement in healthy adults. The main questions it aims to answer are:
Compared the control group, low dose MI group, and high dose MI group to see if there are significant differences in motor performance enhancement, aiming to determine the effectiveness of MI and the optimal dose for practice. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE maskingDescription: The participants were blinded about which group they were allocated (control or intervention) whoMasked: PARTICIPANT count: 27 type: ACTUAL name: Motor imagery training name: NO motor imagery training measure: Time measure: Errors sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Concordia University Wisconsin city: Mequon state: Wisconsin zip: 53097 country: United States lat: 43.21573 lon: -88.02962 facility: Kafrelshaikh University city: Kafr Ash Shaykh zip: 12623 country: Egypt lat: 31.11174 lon: 30.93991 hasResults: False