hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06323798 id: 2024PI035 briefTitle: Diffusion Weighted MRI Enables Differential Diagnosis Between Pyocele and Mucocele overallStatus: NOT_YET_RECRUITING date: 2024-04-28 date: 2024-07-28 date: 2024-12-28 date: 2024-03-21 date: 2024-03-21 name: Central Hospital, Nancy, France class: OTHER briefSummary: Diffusion MRI should allow for differentation of pus and simple retention in the paranasal sinuses, but this remained to be determined conditions: Pyocele; Sinus studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 20 type: ESTIMATED name: MRI measure: apparent diffusion coefficient sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06323785 id: 2022-D0067 briefTitle: Whole-body Hyperthermia for Depression overallStatus: RECRUITING date: 2024-04-30 date: 2026-03-01 date: 2026-03-01 date: 2024-03-21 date: 2024-04-24 name: University of Zurich class: OTHER briefSummary: The goal of this clinical trial is to test the efficacy of whole-body hyperthermia in major depression. The main question it aims to answer is:
Participants will be randomised to sham or active whole-body hyperthermia. The study will last 6 weeks during which five visits will take place. Depression will be measured repeatedly and biological mechanisms will be investigated. conditions: Major Depressive Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Active whole-body hyperthermia name: Sham whole-body hyperthermia measure: Hamilton Rating Scale for Depression (HAMD-17; minimum: 0, maximum: 68, higher scores indicate higher depression) measure: Beck Depression Inventory (BDI; minimum: 0, maximum: 63; higher scores indicate higher depression) measure: Medical Outcomes Study 36-item short-form health survey (MOS-SF; minimum: 0, maximum: 100, higher scores indicate better health status) measure: Hamilton Rating Scale for Depression (HAMD-17; minimum: 0, maximum: 68, higher scores indicate higher depression) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Zurich, Institute of Psychology status: RECRUITING city: Zurich zip: 8050 country: Switzerland name: Susanne Fischer, PhD role: CONTACT phone: +41446357460 email: s.fischer@psychologie.uzh.ch lat: 47.36667 lon: 8.54999 hasResults: False
nctId: NCT06323772 id: RDC-RP-01 briefTitle: Natural History Study in Patients With PDE6A-, PDE6B- and RHO-linked Retinitis Pigmentosa overallStatus: RECRUITING date: 2023-11-17 date: 2027-03 date: 2027-03 date: 2024-03-21 date: 2024-03-21 name: University Hospital Tuebingen class: OTHER briefSummary: The aim of the study is to apply a novel clinical investigation protocol in patients with Phosphodiesterase 6A (PDE6A), PDE6B and Rhodopsin (RHO)-based retinitis pigmentosa. This novel, multimodal clinical examination protocol describes and correlates structural, functional and metabolic aspects during natural disease development.
Test-retest variability of new measurements as well as correlations of the structural, functional, and metabolic changes will be defined to be able to define well-suited readouts for safety and efficacy of future treatment developments before they reach the clinical phase. conditions: Retinitis Pigmentosa studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 40 type: ESTIMATED measure: Optical coherence tomography (OCT) measure: Fundus autofluorescence imaging measure: Wide-field fundus photography measure: Adaptive optics imaging measure: V1 morphology (MRI) measure: Diffusion Tensor Imaging (DTI) measure: flavoprotein fluorescence (FPF) measure: Retinal oxymetry measure: Local dark adapted adaptation curves measure: best corrected visual acuity (BCVA) measure: Static cone perimetry and dark adapted perimetry measure: chromatic pupil campimetry (CPC) measure: electroretinogram (ERG) measure: Virtual reality (VR) functional test sex: ALL minimumAge: 5 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Institute for Ophthalmic Research, University Tübingen status: RECRUITING city: Tübingen state: Baden-Württemberg zip: 72076 country: Germany name: Katarina Stingl, Prof role: CONTACT phone: 070712988088 email: katarina.stingl@med.uni-tuebingen.de lat: 48.52266 lon: 9.05222 hasResults: False
nctId: NCT06323759 id: 2022-14 briefTitle: Perinatal EDucation: Pedagogical Strategy and Facilitators for the PROMotion of BreastFeeding acronym: PED-PROM-BF overallStatus: COMPLETED date: 2023-02-06 date: 2024-03-01 date: 2024-03-01 date: 2024-03-21 date: 2024-03-21 name: Lépine Alexandra class: OTHER briefSummary: Breastfeeding up to 6 months of a child's life, for its benefits to mother and child, has become a global public health goal. However, there is a disparity in the prevalence of breastfeeding (BF) in different regions of the world. According to French perinatal surveys, the rate of BF at birth decreased significantly between 2010 and 2016. Even if that figure remains stable according to the last perinatal survey in 2021, it decreases sharply, to 34.4%, at 2 months.While many plans at the national level advocate for BF, it is rare to see an action plan or an education intervention for women and couples aimed at promoting BF. However, women's needs to educate about BF and the need for professionals to reflect on their practices are highlighted by numerous perinatal surveys. It should be noted that despite the importance given to the promotion of BF found in all National Nutrition and Health Programs, none of them provide pedagogical means or an education program to achieve the objectives set. At present, in France, there is no breastfeeding education program and professionals accompany women by implementing experimental actions without considering the complexity of the promotional dimension (producing a behavioral change) and the educational dimension (understanding the pedagogy of the proposed actions) conditions: Breast Feeding studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: This intervention is based on a pedagogical engineering that proposes a favorable learning environment more adapted than the courses already offered in preparing for parenthood and promoting breastfeeding primaryPurpose: OTHER masking: NONE count: 128 type: ACTUAL name: educational intervention measure: To find out the contribution of educational engineering to the choice and continuation of breastfeeding from the point of view of women until 4 months after the birth of the child. measure: To explain contexts and generative mechanisms of pedagogical design that influence breastfeeding management up to 4 months afther birth. measure: To explain interactions between existing contexts, generative mechanisms and effects on women's breastfeeding management skills. measure: To determine contexts and generative mechanisms of pedagogical design that influence women's knowledge of breastfeeding up to 4 months afther birth. measure: To evaluate the level of satisfaction about the educational intervention among nursing mothers. sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Université Sorbonne Paris Nord - Laboratoire d'Educations et Promotion de la Santé - UR 3412 city: Bobigny zip: 93017 country: France lat: 48.9 lon: 2.45 hasResults: False
nctId: NCT06323746 id: HR-EEG-CSAR briefTitle: Exploring Heart Rate Variability, EEG Pattern, and Corticomuscular Coherence After Cervical Sagittal Alignment Restoration overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-03 date: 2026-12 date: 2024-03-21 date: 2024-03-21 name: University of Sharjah class: OTHER briefSummary: The goal of this Randomized clinical trial is to learn about how fixing neck curvature and head posture right away affects heart rate, brainwaves, and muscle coordination in college athletes. The main question it aims to answer:
- Whether forward head posture (FHP) may play a crucial role in affecting heart rate variability, brainwaves, and muscle coordination. conditions: Cervical Lordosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Permuted block randomization to ensure an equal number of allocations in each of the two groups (intervention and wait list group). Each random block will be stored in opaque sealed envelopes consecutively numbered with a third researcher. Once each participant officially joins the study the researcher will open the subsequent envelop. whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Denneroll cervical traction orthodontic measure: Cervical Sagittal Alignment Radiographs measure: Cervical Sagittal Alignment Radiographs measure: Heart rate Variability (HRV) physiological parameter measure: Corticomuscular Coherence sex: ALL minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: University of Sharjah city: Sharjah zip: 0000 country: United Arab Emirates name: Ibrahim Mostafa Abuamr, professor role: CONTACT email: iabuamr@sharjah.ac.ae name: Shima Zadeh, Research Assistant role: SUB_INVESTIGATOR name: Ibrahim Mostafa Abuamr, Professor role: PRINCIPAL_INVESTIGATOR lat: 25.33737 lon: 55.41206 hasResults: False
nctId: NCT06323733 id: 2CAPA briefTitle: Exercise Intervention for Patients With Cancer Cachexia: Effects of a 12-week Program and One-year Follow-up. acronym: 2CAPA overallStatus: ENROLLING_BY_INVITATION date: 2024-01-01 date: 2026-01 date: 2026-01 date: 2024-03-21 date: 2024-03-21 name: Peyrachon Romane class: OTHER briefSummary: The prevalence of cancer with cachexia is rising sharply. More than 80% of digestive cancer patients are affected by cancer cachexia. Cachexia leads to weight loss, and reduces quality of life (QoL), cancer treatment response and survival. Exercise could counteract the deleterious effects of cachexia. The 2CAPA study aims to assess the effectiveness of a 12-week exercise program on various symptoms associated with cancer cachexia, including Health-Related QoL (HRQoL), fatigue, appetite, body composition, physical fitness, and physical activity levels. Additionally, it seeks to examine compliance with the exercise program, identify barriers to regular exercise and determine how compliance influences physical and psychological effects. Furthermore, this study aims to determine the maintenance of physical activity levels and the effects post-program for one year follow-up on cachexia-related symptoms.
Methods: This study will include 31 cancer patients with cachexia. Participants will receive a supervised exercise program lasting 12-weeks with two sessions per week combining endurance and resistance training. Outcomes include HRQoL, fatigue, appetite, anthropometric parameters, physical performances, and physical activity levels at baseline, at the end of the 12-week exercise program, and at 3-, 6- and 12- months post-intervention. conditions: Cachexia-Anorexia Syndrome studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 31 type: ESTIMATED name: Exercise Intervention measure: Health-Related Quality of Life measure: Body weight measure: Body mass index measure: Lean mass measure: Fat mass measure: Aerobic fitness measure: Muscular strength of the lower limbs measure: Handgrip strength measure: Static balance ability measure: Appetite measure: Cancer-related Fatigue measure: Physical Activity and Sedentary Levels measure: Stages of change for exercise measure: Exercise beliefs measure: Compliance to exercise intervention measure: Reasons for absence measure: Timing of absences measure: Fidelity to session duration measure: Fidelity to session intensity measure: Reasons to modify exercise sessions measure: Incidence of Adverse Events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: SPORMED city: Rennes state: Bretagne zip: 35000 country: France lat: 48.11198 lon: -1.67429 hasResults: False
nctId: NCT06323720 id: ONZ-2023-0442 briefTitle: Signs of Central Sensitization in Tension-type Headache acronym: CSTTH overallStatus: RECRUITING date: 2024-02-23 date: 2025-07 date: 2025-12 date: 2024-03-21 date: 2024-04-01 name: University Ghent class: OTHER briefSummary: The goal of this observational study is to assess the pain sensitivity in tension-type headache patients. The main question it aims to answer is:
Researchers will compare tension-type headache patients with healthy controls to see if signs of central sensitization are only present in the tension-type headache group. conditions: Tension-Type Headache studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 66 type: ESTIMATED name: Quantitative Sensory Testing measure: Pain sensitivity for heat stimuli measure: Pain sensitivity for cold stimuli measure: Pain sensitivity for electrical stimuli measure: Pain sensitivity for pressure measure: Function of the pain facilitating pathways measure: Function of the pain inhibiting pathways sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ghent University status: RECRUITING city: Ghent state: East-Flanders zip: 9000 country: Belgium name: Jessica Van Oosterwijck, Prof. role: CONTACT lat: 51.05 lon: 3.71667 hasResults: False
nctId: NCT06323707 id: IMPACT briefTitle: The IMPACT Implementation-Effectiveness Trial acronym: IMPACT overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2027-03-15 date: 2027-03-15 date: 2024-03-21 date: 2024-03-21 name: McMaster University class: OTHER name: Canadian Cancer Society (CCS) name: Hamilton Health Sciences Corporation name: Niagara Health System briefSummary: More Canadians are surviving cancer, however, individuals with cancer live with side effects for years after treatments have ended. The physical and psychosocial benefits of regular physical activity (PA) during and after cancer treatment are well established. However, less than 30% of individuals with cancer meet current PA recommendations and PA levels decline significantly during treatment. PA services within the cancer institution to support well-being during treatment are not available for survivors across Ontario. Strategies are needed within cancer centres to close the gap between the evidence and clinical practice.
Why is this work important? Findings from this trial will inform the way PA services are provided within cancer institutions across Ontario. This novel strategy incorporates both institution-based and home-based exercise strategies during treatment and highlights the importance of individuals with cancer taking an active role in managing their condition during treatment. This can prevent future complications and decrease burden on the individual and the healthcare system. Results will inform future decisions on PA implementation strategies for cancer survivors with diverse needs across Ontario. conditions: Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 129 type: ESTIMATED name: Exercise name: Self-management e-module measure: Physical activity level measure: Physical activity level measure: Physical activity level measure: Quality of life measure: Quality of life measure: Quality of life measure: Level of exercise knowledge measure: Level of exercise knowledge measure: Level of exercise knowledge measure: Health status measure: Health status measure: Health status measure: Aerobic capacity measure: Aerobic capacity measure: Aerobic capacity measure: Cardiovascular outcomes - Blood pressure measure: Cardiovascular outcomes - Blood pressure measure: Cardiovascular outcomes - Blood pressure measure: Cardiovascular outcomes - Heart rate measure: Cardiovascular outcomes - Heart rate measure: Cardiovascular outcomes - Heart rate measure: Health care utilization measure: Health care utilization measure: Health care utilization sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06323694 id: Attesa chirurgia-1 briefTitle: Quality of Life, Expectations, Thoughts and Fears of Patients on the Waiting List for Spinal Surgery acronym: chirurgia-1 overallStatus: COMPLETED date: 2022-05-15 date: 2024-01-25 date: 2024-02-16 date: 2024-03-21 date: 2024-04-16 name: Istituto Ortopedico Rizzoli class: OTHER name: University of Bologna briefSummary: The objective of this qualitative prospective observational study is to analyze the cognitive aspect, the emotional-behavioral state and the quality of life of patients during their stay on the waiting list for two categories of lumbar spinal surgery: arthrodesis and percutaneous vertebroplasty.
The two types of surgery differ both in the surgical procedure and in the duration of the wait before surgery, which is 1-2 months for vertebroplasty and more than one year for spinal arthrodeses which are not of urgency or priority. conditions: Spinal Surgery studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 15 type: ACTUAL name: quality of life measure: Descriptive survey for vertebroplasty patients measure: Descriptive survey for spinal arthrodeses patients sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istituto Ortopedico Rizzoli city: Bologna zip: 40136 country: Italy lat: 44.49381 lon: 11.33875 hasResults: False
nctId: NCT06323681 id: Leading Study briefTitle: Pegylated Interferon α in Previously Interferon-treated CHB（Leading Study） overallStatus: RECRUITING date: 2024-02-04 date: 2027-02 date: 2027-08 date: 2024-03-21 date: 2024-03-21 name: Qing XIe class: OTHER briefSummary: Previous clinical practice and exploratory studies suggest that some patients who have not achieved functional cure in the first round of interferon therapy can achieve HBsAg clearance by interferon retreatment (intermittent therapy), which can reduce the occurrence of complications such as liver fibrosis, liver cirrhosis and liver cancer, and its clinical benefit is expected to be higher than that of NAs monotherapy.
This study is aimed to conduct a large-scale, multicenter, prospective study to confirm the benefit of peginterferon-based therapies in these populations. It expected to enroll about 2000 patients with chronic hepatitis B who have received prior interferon therapy and achieved a good response but without function cure, patients receive either interferon-based therapy or NAs monotherapy, according to their wishes and doctors' professional recommendations, with a ratio of 2:1 between the two groups, and all patients treated for 48 weeks. The HBsAg clearance rate before and after treatment, safety, etc. will be analyzed. conditions: Chronic Hepatitis b studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 2016 type: ESTIMATED name: Peginterferon α-2b based treatment group name: NAs monotherapy group measure: Proportion of patients with HBsAg below the lower limit of detection. measure: Decrease of HBV DNA levels at week 48 compared to baseline. measure: Proportion of patients with HBV DNA below the lower limit of detection. measure: Decrease of HBsAg levels at week 48 compared to baseline. measure: Proportion of patients with HBsAg seroconversion. measure: Proportion of patients with HBeAg below the lower limit of detection for patients with baseline HBeAg positive. measure: Proportion of patients with HBeAg seroconversion for patients with baseline HBeAg positive. measure: Serious adverse events. sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Infectious Diseases , Ruijin Hospital, Shanghai Jiao Tong University School of Medicine status: RECRUITING city: Shanghai state: Shanghai country: China name: Qing Xie, MD, PhD. role: CONTACT phone: 0086-021-64370045 phoneExt: 680403 email: xieqingrjh@163.com name: Honglian Gui, MD,PhD role: CONTACT phone: 0086-021-64370045 phoneExt: 680419 email: lillian_ghl@163.com name: Qing Xie, MD, PhD. role: PRINCIPAL_INVESTIGATOR lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06323668 id: H-23067693 briefTitle: Cardiac Implantable Electronic Device remOval Versus Full coUrse Medical Treatment acronym: CIEDOUT overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2028-06 date: 2038-01-31 date: 2024-03-21 date: 2024-03-21 name: Rigshospitalet, Denmark class: OTHER briefSummary: The CIEDOUT study is an open label randomized trial in patients with possible cardiac implantable electronic device (CIED) infection.
The objective of this study is to test whether CIED removal + guideline antibiotic therapy is superior to 6-weeks antibiotic therapy alone in prevention of the composite endpoint of death or relapse bacteremia after 6 months of follow-up in patients with CIED and systemic infection but without definite CIED infection. conditions: Cardiac Implantable Electronic Device Infection studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized open label trial primaryPurpose: TREATMENT masking: NONE maskingDescription: None (Open Label) count: 180 type: ESTIMATED name: Cardiac implantable electronic device extraction name: Empirical antibiotic therapy measure: Rate of death or relapse bacteremia measure: Days alive and out-of-hospital measure: Rate of death measure: Rate of readmission for any cause measure: Rate of cardiac implantable electronic device extraction measure: Rate of relapse bacteremia (the same microorganism) measure: Rate of bacteremia (all species) measure: Rate of definite CIED infection sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06323655 id: VP-VEC-162-1201 briefTitle: Evaluation of Next-Day Residual Effects of Tasimelteon Compared With Placebo and Active Control in Healthy Subjects overallStatus: COMPLETED date: 2018-07-19 date: 2018-08-28 date: 2018-08-28 date: 2024-03-21 date: 2024-03-21 name: Vanda Pharmaceuticals class: INDUSTRY briefSummary: The aim of this study is to investigate next-day residual effects of tasimelteon compared with placebo and active control in healthy subjects. conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 48 type: ACTUAL name: Tasimelteon name: Active Control Placebo name: Tasimelteon Placebo name: Active Control measure: Next-day effects on simulated driving performance as measured by changes in Standard Deviation of Lateral Position (SDLP) sex: ALL minimumAge: 21 Years maximumAge: 55 Years stdAges: ADULT facility: Vanda Investigational Site city: Laval state: Quebec country: Canada lat: 45.56995 lon: -73.692 hasResults: False