hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06335654 id: 24K056-001 briefTitle: Real-time Artificial Intelligence-based Endocytoscopic Diagnosis of Colorectal Neoplasms overallStatus: RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2024-12-31 date: 2024-03-28 date: 2024-04-18 name: The First Hospital of Jilin University class: OTHER briefSummary: Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related death worldwide. Colonoscopy is considered the preferred method of screening for colorectal cancer, and resection of colorectal lesions can significantly reduce the incidence and mortality of colorectal cancer. In order to improve the qualitative and quantitative diagnosis of colorectal lesions, many endoscopic techniques, such as image-enhanced endoscopy (IEE), including narrowband imaging (NBI), magnifying endoscopy, pigment endoscopy, confocal laser endoscopy, and endocytoscopy (EC) are applied clinically. However, with the increasing number of endoscopic resection, the costs associated with the pathological diagnosis of endoscopic resection and resection specimens increase year by year. In clinical practice, some non-neoplastic colorectal lesions may not require resection, so it is important to distinguish neoplastic from non-neoplastic during colonoscopy. The application of EC is intended to achieve the purpose of real-time histopathological endoscopic diagnosis without biopsy. Several studies have shown that EC is effective in identifying the nature of colorectal lesions and judging the depth of invasion in CRC. Based on the endoscopic diagnosis, the endoscopist can determine the treatment plan for the colorectal lesions. The latest EC is an integrated endoscope with a contact light microscopy system with a maximum magnification of 520 x. EC can demonstrate the atypical of gland structure and cells after staining and display the super-amplified surface microvessels of the lesion under the EC-NBI mode. However, the judgment of endocytoscopic images needs a lot of experience to improve the diagnostic accuracy. Moreover, endoscopists have certain subjective judgments and errors in endocytoscopic diagnosis. There is an artificial intelligence system which has been developed to identify colorectal neoplasms. However, there is still a lack of prospective clinical verification based on Chinese population. In the study, the investigators performed a prospective clinical study to determine the diagnostic accuracy of artificial intelligence system. conditions: Colorectal Neoplasms studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 350 type: ESTIMATED name: artificial intelligence system measure: sensitivity measure: specificity measure: accuracy measure: positive predictive value measure: negative predictive value measure: high confidence diagnosis rate sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: First hospital of Jilin University status: RECRUITING city: Changchun state: Jilin zip: 130021 country: China lat: 43.88 lon: 125.32278 hasResults: False
nctId: NCT06335641 id: COOLHD24-CAN briefTitle: Head COOLing in iscHemic Stroke Patients Undergoing EndovAscular Thrombectomy: a Feasibility and Safety stuDy acronym: COOLHEAD-2-CAN overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-04-01 date: 2024-03-28 date: 2024-03-28 name: University of Calgary class: OTHER briefSummary: This is an investigator-initiated, prospective, open-label, single-arm, non-randomized study to assess the safety and feasibility of external active conductive head cooling during endovascular thrombectomy procedures. conditions: Stroke, Acute studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: External active conductive head cooling measure: Adherence to the intervention. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06335628 id: RCT: CTG-VCMX briefTitle: Volumetric Dimensional Changes After Surgical Pontic Site Development Procedures With Connective Tissue Graft or Collagen Matrix overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2029-04 date: 2024-03-28 date: 2024-03-28 name: University of Bern class: OTHER briefSummary: The aim of this research project is to compare two surgical procedures to improve soft tissue volume. Both procedures have already been validated, but despite their great clinical relevance, little data exists in the literature. With this study, the investigators aim to evaluate volumetric changes of connective tissue graft versus biomaterial (membrane). In addition, further clinical measurements will be taken and patient satisfaction will be assessed. conditions: Connective Tissue Graft conditions: Volume Collagen Matrix Xenograft studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 38 type: ESTIMATED name: Geistlich Fibro-Gide® measure: Volumetric dimensional changes measure: Clinical: PPD measure: Clinical BoP measure: Clinical: Suppuration measure: Clinical: Mucosa measure: Clinical: ktw measure: Clinical: Mobility measure: Clinical: Thickness measure: Clinical: Contributing factors measure: Patient-reported satisfaction measure: Patient-reported esthetics measure: Patient-reported discomfort measure: Patient-reported pain measure: Prosthetics Survival measure: Prosthetics Sucess measure: Prosthetics Complications measure: Prosthetics PES-WES measure: Prosthetics: Occlusal measure: Prosthetics: Interproximal measure: Radiographics BL measure: Radiographics PP measure: Radiographics distance measure: Radiographics Contacts sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Bern city: Bern zip: 3010 country: Switzerland name: Martin Schimmel, Prof. role: CONTACT phone: +41316840630 email: martin.schimmel@unibe.ch name: Manrique Fonseca, Dr. med. dent. role: PRINCIPAL_INVESTIGATOR lat: 46.94809 lon: 7.44744 hasResults: False
nctId: NCT06335615 id: FMG-5790_2023 briefTitle: A Brief Acceptance Intervention for Stress to Improve Students' Well-Being overallStatus: COMPLETED date: 2023-11-27 date: 2023-12-19 date: 2023-12-19 date: 2024-03-28 date: 2024-03-28 name: VU University of Amsterdam class: OTHER briefSummary: The goal of this randomized controlled trial is to test a brief psychological intervention that focusses on acceptance of stress in a student population. The main questions it aims to answer are:
Students that receive the intervention will be compared to students that merely received psychoeducation about stress and acceptance to see if the intervention lead to larger increases in well-being. conditions: Stress studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 116 type: ACTUAL name: Brief Acceptance Intervention name: Psychoeducation measure: Psychological Well-Being measure: State Anxiety measure: Study Stress measure: Interoceptive awareness measure: Psychological Flexibility sex: ALL minimumAge: 17 Years maximumAge: 29 Years stdAges: CHILD stdAges: ADULT facility: University of Amsterdam city: Amsterdam state: Noord-Holland zip: 1018 WS country: Netherlands lat: 52.37403 lon: 4.88969 hasResults: False
nctId: NCT06335602 id: 202301283A3 briefTitle: TCM for Post-operative Edema overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2025-09-30 date: 2025-12-31 date: 2024-03-28 date: 2024-03-28 name: Chang Gung Memorial Hospital class: OTHER briefSummary: There are loads of research on knee surgery, including surgical methods, rehabilitation strategies, and complication prevention. Whether it is general surgery or endoscopic surgery, there may be postoperative joint swelling, which may last for several weeks depending on the patient's condition. Therefore, reducing swelling as soon as possible is important in post-operative treatment. Swelling of the knee joint may increase soft tissue tension, causing pain and discomfort, and affecting the range of motion and functional recovery of the joint. It may also affect wound healing and increase the risk of complications such as infection and thrombosis. Most clinical research related to traditional Chinese medicine focuses on reducing pain, and little attention is paid to reducing swelling, relatively. Nevertheless most relevant literatures discuss total knee replacement surgery.
Cruciate ligament surgery is very common in sports medicine orthopedics. It is expected that ordinary patients get function recovery quickly after surgery, and athletes can return to play as soon as possible. This study is a prospective study, with partially double-blinded, randomized controlled study design. The investigators are aiming to TCM intervention for knee swelling after cruciate ligament surgery, and evaluation of postoperative swelling and functional improvement. TCM intervention methods are laser acupuncture and external application of herbal medicine. conditions: Anterior Cruciate Ligament Injuries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: LASER acupuncture measure: Leg girth measurement measure: VAS measure: WOMAC measure: Tegner score sex: MALE minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT hasResults: False
nctId: NCT06335589 id: CDX 24-002 briefTitle: Adapting Treatment Delivery to Improve Retention in Evidence-Based PTSD Treatment overallStatus: NOT_YET_RECRUITING date: 2024-06-17 date: 2026-12-31 date: 2026-12-31 date: 2024-03-28 date: 2024-03-28 name: VA Office of Research and Development class: FED briefSummary: Posttraumatic stress disorder (PTSD) is prevalent among Veterans and effective evidence-based psychotherapies (EBPs) for PTSD have been implemented within the Veterans Health Administration (VHA). However, retention in PTSD EBPs is poor. Premature dropout is associated with worse clinical outcomes and greater healthcare utilization. Delivery of PTSD EBPs in a massed format, typically three or more days per week delivered within a month, have shown promise for increasing retention. The present study is a pilot feasibility and acceptability study comparing massed PTSD treatment to treatment as usual (e.g., typically weekly treatment). conditions: Stress Disorders, Post-Traumatic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Massed PTSD treatment (e.g., cognitive processing therapy \[CPT\] or prolonged exposure \[PE\] therapy delivered at least 3 times per week) will be compared to CPT \& PE delivered as usual, which is usually once per week. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Clinical interviewers who assess primary outcomes will not be informed of participant's randomization assignment. whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: EBP-Massed name: EBP-TAU measure: Treatment completion measure: Acceptability of Intervention (AIM) measure: Client Satisfaction Questionnaire-8 (CSQ-8) measure: Clinician Administered PTSD Scale for DSM-5 (CAPS-5) Severity Score measure: Clinician Administered PTSD Scale for DSM-5 (CAPS-5) Severity Score measure: Session attendance measure: Patient Health Questionnaire-9 (PHQ-9) measure: Patient Health Questionnaire-9 (PHQ-9) measure: Brief Inventory of Psychosocial Functioning (BIPF) measure: Brief Inventory of Psychosocial Functioning (BIPF) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Durham VA Medical Center, Durham, NC city: Durham state: North Carolina zip: 27705-3875 country: United States name: Stephanie Y Wells, PhD MS BA role: CONTACT phone: 919-286-0411 phoneExt: 134053 email: stephanie.wells2@va.gov name: Laurel B Koss, MS OTR role: CONTACT phone: (919) 286-0411 phoneExt: 775648 email: laurel.koss@va.gov name: Stephanie Y Wells, PhD MS BA role: PRINCIPAL_INVESTIGATOR lat: 35.99403 lon: -78.89862 hasResults: False
nctId: NCT06335576 id: ZSGCproteomics briefTitle: Establishment of Serum Proteomics Subtypes of Gastric Cancer and Its Clinical Application overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2026-10-31 date: 2026-12-31 date: 2024-03-28 date: 2024-03-28 name: Shanghai Zhongshan Hospital class: OTHER briefSummary: This study is a prospective, single-center, observational study aimed at detecting the status of serum protein profiles at key time points in gastric cancer patients receiving neoadjuvant therapy for advanced disease, and constructing a serum protein model for evaluating the efficacy of neoadjuvant therapy for gastric cancer. Subjects will receive neoadjuvant therapy (treatment regimen determined by the primary physician, limited to systemic therapy, with options including immune checkpoint inhibitor-based regimens and non-immune checkpoint inhibitor-based regimens). After four cycles of treatment, the efficacy will be assessed. Patients eligible for R0 resection will undergo D2 radical surgery regardless of tumor regression, while those ineligible for R0 resection will enter the palliative treatment phase (Note: Subjects are all patients who require neoadjuvant therapy even if they do not participate in this clinical study). Patients will receive regular follow-up evaluations for metastasis/recurrence and survival until tumor recurrence/progression or the last known date of patient survival (Note: Regular follow-up in this study follows the frequency of routine clinical follow-ups). The primary endpoint is progression-free survival (PFS), and the secondary endpoint is pathological response rate (based on Becker tumor regression grading, with residual tumor less than 50% considered effective preoperative treatment).
Peripheral venous blood samples will be collected before the start of neoadjuvant therapy (blood sampling point 1 - baseline) and before surgery after neoadjuvant therapy (blood sampling point 2 - post-treatment). Approximately 3 ml of blood will be collected each time, and about 1.5 ml of serum will be obtained after processing. Serum protein profiling will be conducted to assess the expression of protein profiles at these treatment time points. conditions: Gastric Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 89 type: ESTIMATED name: This study is a single-arm and observational study with no intervention. measure: C-index measure: Sensitivity and specificity of model sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06335563 id: STAR009 briefTitle: Augmented Reality Navigation Versus Traditional CT Guidance for Preoperative Localization of Pulmonary Nodules overallStatus: RECRUITING date: 2024-03-14 date: 2024-12-01 date: 2024-12-01 date: 2024-03-28 date: 2024-04-12 name: Shanghai Pulmonary Hospital, Shanghai, China class: OTHER briefSummary: This study aims to conduct a large-sample randomized controlled clinical trial, using traditional CT-guided thoracic puncture localization as a comparison, to explore the accuracy, safety and clinical advantages of Intelligent AR glasses in assisting preoperative localizing of small pulmonary nodules. conditions: Pulmonary Nodule studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: AR glasses-assisted puncture localizing group versus CT-guided conventional pulmonary nodule puncture localizing group primaryPurpose: TREATMENT masking: NONE maskingDescription: no masking count: 166 type: ESTIMATED name: AR glasses-assisted pulmonary nodule puncture localization name: CT-guided pulmonary nodule puncture localization measure: Accuracy of puncture localization of pulmonary nodules measure: Success rate of puncture localization of pulmonary nodules measure: Adjust the number of needle punctures measure: Operating time measure: Radiation dose sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shanghai Pulmonary Hospital status: RECRUITING city: Shanghai state: Shanghai zip: 200433 country: China name: Shenghao Huang role: CONTACT email: huangshplus5@163.com lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06335550 id: 2021/2680 briefTitle: Surgical and Patient Reported Outcomes in Robotic Mastectomy overallStatus: COMPLETED date: 2022-11-24 date: 2023-12-31 date: 2024-03-01 date: 2024-03-28 date: 2024-03-28 name: Changi General Hospital class: OTHER briefSummary: Conventional nipple and/or skin-sparing mastectomy (NSM/SSM) with or without immediate reconstruction is becoming one of the mainstream surgical treatment for breast cancer and risk reducing mastectomy in recent years. While this technique provides satisfactory oncologic and aesthetic outcomes, its disadvantages include skin flap and/or nipple-areolar complex (NAC) necrosis, NAC malposition/distortion as well as visible scar(s) on the breast.
The aim of this study is to conduct a single-arm prospective pilot study to investigate the safety and feasibility as well as learning curve of R-NSM/R-SSM. conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 29 type: ACTUAL name: Robotic mastectomy measure: Surgical Outcomes - Operative parameters measure: Surgical Outcomes - Length of stay (days) measure: Surgical Outcomes- 30-days morbidity/complications measure: Oncologic outcomes measure: Learning curve sex: FEMALE minimumAge: 21 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Changi General Hospital city: Singapore zip: 529889 country: Singapore lat: 1.28967 lon: 103.85007 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-07-05 uploadDate: 2024-03-08T05:13 filename: Prot_SAP_000.pdf size: 785756 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-05-03 uploadDate: 2024-03-08T05:19 filename: ICF_001.pdf size: 704077 hasResults: False
nctId: NCT06335537 id: 2405 briefTitle: Impact of Sodium Bicarbonate on 24-hour Urine Parameters in Hypocitriuric and Uric Acid Stone Formers overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-07 date: 2026-02 date: 2024-03-28 date: 2024-04-24 name: University of California, Irvine class: OTHER briefSummary: The incidence of kidney stone disease continues to rise globally. Although the treatment of kidney stone disease has dramatically improved in recent years, surgical management remains invasive and expensive. Patients who develop kidney stones are at high risk of recurrence during their lifetime; therefore, prevention of stones should be a primary focus. Low levels of citrate and acidic urine are risk factors for the formation of kidney stones such as calcium oxalate and uric acid, respectively. Calcium oxalate stones are the predominant stone composition in the United States, accounting for over 2/3rds of stones. Citrate is a key inhibitor of calcium oxalate crystal formation and thus increasing it in the urine of a calcium oxalate stone former is quite beneficial. Uric acid stones account for approximately 10 percent of all stone types. These stones form primarily due to an acidic urinary environment which is a prerequisite for crystal formation. Common medications for stone formers include potassium citrate which help to make the urine more alkaline. Although effective, these medications have side effects and may prove to be too expensive (upwards of $450/month). Consuming baking soda (sodium bicarbonate) may prove to be an inexpensive ($0.34/month) equally effective alternative with respect to increasing urinary citrate levels and alkalinizing the urine. Investigators hypothesize that twice a day oral baking soda in a liquid medium (e.g., water, orange juice, soda, etc.) can be an effective, and inexpensive alternative to urocit K with regard to alkalinizing the urine and raising urinary citrate levels. conditions: Uric Acid Stones studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: The following study will be a randomized cross-over trial evaluating the effects of baking soda and Urocit-K on 24-hour urinary parameters in hypocitrituric calcium oxalate and uric acid stone formers. All participants that consent to participate in the study will undergo the same tests.
Participants will begin a 2-week washout period of Urocit-K as their standard of care. After completion of the washout period subjects will be randomized to take either Urocit-K or Baking Soda for 4 weeks. After participants undergo a secondary 2-week washout period, then they are assigned to medication not taken in the first study period for 4 weeks. primaryPurpose: TREATMENT masking: NONE maskingDescription: This is an unblinded study. count: 100 type: ESTIMATED name: Potassium citrate name: Sodium bicarbonate measure: Change in 24-hour Urinary pH measure: Change in 24-hour Urinary Citrate measure: Change in Supersaturation of Calcium Oxalate measure: Change in Supersaturation of Uric acid sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of California, Irvine Medical Center city: Orange state: California zip: 92868 country: United States lat: 33.78779 lon: -117.85311 hasResults: False
nctId: NCT06335524 id: IRB-300012718 briefTitle: Infant-Maternal Partnership and Cognitive Training Study for Preterm Infants acronym: IMPACT overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2026-08 date: 2028-08 date: 2024-03-28 date: 2024-03-28 name: University of Alabama at Birmingham class: OTHER briefSummary: This study will test the hypothesis that in preterm infants a caregiver-implemented early developmental intervention (EDI) using finger puppets to develop joint attention and encourage interactive communication with routine EDI care including Bookworm training compared with routine EDI care including Bookworm training alone will increase the Ages and Stages Questionnaire® score at 12 months corrected age. conditions: Child Development conditions: Infant Development conditions: Infant, Premature, Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 188 type: ESTIMATED name: Finger puppet name: Bookworm reading intervention training and routine EDI care. measure: ASQ-3 scores measure: ASQ-3 scores measure: ASQ scores below -2SD measure: ASQ scores below -2SD measure: ASQ scores below -1SD measure: ASQ scores below -1SD measure: ASQ-SE2 scores measure: ASQ-SE2 scores measure: Severe neurodevelopmental impairment measure: Moderate or severe neurodevelopmental impairment measure: Cognitive Composite Score on BSID-IV measure: Language Composite Score on BSID-IV measure: Motor Composite Score on BSID-IV measure: Edinburgh Postnatal Depression Scale measure: MCHAT score sex: ALL minimumAge: 1 Day maximumAge: 17 Weeks stdAges: CHILD hasResults: False