hackint0sh/New-Dataset huggingface dataset:
3. SmartRPD digital workflow Adopts a different teeth profile capture method by using the intraoral scanner to digitally scan and save the subject's teeth profile. From the intraoral scan, a digital model of the subject's teeth profile is created but on the digital model instead, the design of RPD is digitally performed. The digital design is used for additive manufacturing. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 141 type: ESTIMATED name: Group 3 - 3D Printed Removable Partial Denture name: Group 2 - 3D Printed Removable Partial Denture measure: Evaluation of Precision in Fabricated Metal Frameworks Across Three Workflows measure: Comparison of Patient Satisfaction with RPD Prostheses Fabricated Using Three Workflows measure: Comparison of Fabrication Cost and Time Across Three Workflows sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Dental Centre Singapore status: RECRUITING city: Singapore zip: 168938 country: Singapore name: Hazel Goh Si Ying role: CONTACT phone: 63248754 email: goh.si.ying@ndcs.com.sg name: Zi Ying Phang role: PRINCIPAL_INVESTIGATOR name: Khim Hean Teoh role: SUB_INVESTIGATOR name: Janice Tan Zhi Hui role: SUB_INVESTIGATOR lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06273436 id: Pro00130902 briefTitle: Healing, Equity, Advocacy and Respect for Mamas acronym: HEAR4Mamas overallStatus: NOT_YET_RECRUITING date: 2024-04-29 date: 2028-11-30 date: 2028-11-30 date: 2024-02-22 date: 2024-04-22 name: Medical University of South Carolina class: OTHER name: Patient-Centered Outcomes Research Institute briefSummary: The goal of the proposed research is to test the comparative effectiveness of AIM safety bundles for post-partum women delivered in-person vs. via text/phone to improve early detection of and timely care for complications during the first six weeks postpartum for women experiencing significant health disparities. conditions: Postpartum Complication studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 2894 type: ESTIMATED name: H.E.A.R. for Mamas measure: Emergency Department (ED) visits within six weeks postpartum measure: Patient Reported Outcomes (PROs) measure: Social Determinants of Health (SDoH), Patient Activation, Shared Decision Making measure: Patient Activation measure: Shared Decision Making sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT hasResults: False
nctId: NCT06273423 id: OULA for Postpartum Depression briefTitle: Feasibility Evaluation of a Dance Fitness Program overallStatus: NOT_YET_RECRUITING date: 2024-10 date: 2025-05 date: 2025-06 date: 2024-02-22 date: 2024-02-22 name: Montana State University class: OTHER briefSummary: The objective of this pilot project is to assess the feasibility, acceptability, and mental health impact of OULA for women with postpartum depression (PPD). conditions: Postpartum Depression studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 40 type: ESTIMATED name: OULA, Mind-body Physical Activity measure: Feasibility and acceptability measure: Changes in postpartum depression measure: Changes in postpartum anxiety sex: FEMALE minimumAge: 20 Years maximumAge: 39 Years stdAges: ADULT hasResults: False
nctId: NCT06273410 id: 0453-6/2022 briefTitle: Clinical Performance of An Alkasite Based Restorative Material With And Without Adhesive overallStatus: COMPLETED date: 2022-10-13 date: 2023-11-28 date: 2023-11-28 date: 2024-02-22 date: 2024-02-22 name: Hams Hamed Abdelrahman class: OTHER briefSummary: Despite significant advances in composite materials, they are still perceived as technique-sensitive and exhibit failure related to excessive wear and polymerization shrinkage. Cention N is a recently introduced alkasite restorative that contains special reactive fillers. Its application in restorative dentistry may be significant, promoting remineralization of carious lesions \& reduction of polymerization shrinkage. The study will aim to compare the clinical performance of Cention N (with and without adhesive) and composite resin (Filtek Bulk Fill) in class I restorations using FDI criteria. Thirty-six class I cavities will be selected and equally allocated into 3 groups: Group I (n=12): (Cention N with adhesive), Group II (n=12): (Cention N without adhesive) \& Group III (n=12): composite resin (Filtek Bulk Fill) in class I cavities. Patients will be followed up at 1 week 3, 6, and 12 months and evaluated using the FDI criteria. Postoperative sensitivity, staining, and recurrent caries will be evaluated in this clinical trial. conditions: Dental Restoration Failure studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 36 type: ACTUAL name: Cention N name: Cention N + Adhesive name: Bulk Fill Composite measure: Change in pain sensitivity measure: Change in occurrence of recurrent caries measure: Change in occurrence of marginal stains sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Alexandria Faculty of Dentistry city: Alexandria country: Egypt lat: 31.21564 lon: 29.95527 hasResults: False
nctId: NCT06273397 id: ACME-AHF briefTitle: Acetazolamide or Metolazone in Acute Heart Failure acronym: ACME-AHF overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-03-01 date: 2027-05-01 date: 2024-02-22 date: 2024-03-18 name: Clinica Alemana de Santiago class: OTHER briefSummary: Impact of Acute Heart Failure:
According to the World Health Organization (WHO), approximately 26 million people suffer from Heart Failure (HF), with a mortality rate of up to 50% within five years of diagnosis. Acute Heart Failure (AHF) exacerbations, leading to hospitalization, are common and represent the primary cause of hospital admissions in those over 65. Effective decongestion during hospitalization is crucial, as failure to achieve it doubles the risk of rehospitalization and mortality, incurring significant healthcare costs.
Diuretics, particularly loop diuretics like furosemide, are a cornerstone in managing AHF by inducing natriuresis and achieving decongestion. Clinical experience supports their use, though limited clinical trials exist. Pharmacological concepts guide their administration, emphasizing intravenous delivery in high doses and adjusting subsequent doses based on decongestive efficacy. Additionally, sequential tubular blockade with other diuretics like metolazone and acetazolamide is explored to enhance decongestion.
Sequential tubular blockade, using metolazone and acetazolamide in conjunction with furosemide, aims to achieve rapid and effective decongestion. While metolazone targets the distal tubule, inhibiting sodium-chloride channels, acetazolamide affects proximal tubular function. Studies like ADVOR (acetazolamide) and CLOROTIC (thiazide-like diuretic) demonstrate the potential benefits of combining these diuretics for quicker decongestion but with potential risks (in the case of Hydrochlorothiazide).
The ACME-AHF trial is designed to compare the efficacy and safety of two diuretic combination strategies: acetazolamide with furosemide and metolazone with furosemide. The primary objective is to relieve congestion, assessed using a congestion score, within the first three days of treatment during an hospitalization for acute heart failure. conditions: Heart Failure Acute conditions: Decompensated Heart Failure studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is an Open, Multicenter, Prospective, and Randomized study with three treatment arms. The outcomes to be assessed in the initial phase will be at 4 days post-randomization, followed by evaluation at 90 days after hospital discharge. primaryPurpose: TREATMENT masking: NONE count: 1050 type: ESTIMATED name: Acetazolamide 250 MG name: Metolazone 2.5 MG name: Furosemide Injection measure: Treatment success measure: Mortality measure: Worsening Heart Failure measure: Cumulative 24-hour Natriuresis measure: Cumulative weight loss measure: Subclinical congestion measure: Change in Hematocrit value measure: Change in NT-proBNP concentration measure: Change in CA125 value measure: Any adverse event measure: Changes in pH value measure: Change in plasma electrolyte values sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06273384 id: Si 062/2023 briefTitle: Diagnostic Performance of CIM for Helicobacter Pylori Infection in Patients With Peptic Ulcer Bleeding acronym: CIM overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-09-30 date: 2024-12-31 date: 2024-02-22 date: 2024-02-22 name: Mahidol University class: OTHER briefSummary: The goal of this cross-sectional study is to evaluate the efficacy of current infection marker (CIM) method for H. pylori detection. The main questions it aims to answer are:
* To evaluate the efficacy of CIM method for H. pylori detection compared to rapid urease test(RUT), histopathology, polymerase chain reaction (PCR), and urea breath test (UBT) in patients who presented with upper gastrointestinal hemorrhage from peptic ulcer, and their sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio, and negative likelihood ratio.
* To study the associated factors in false negative value of H. pylori detection methods with CIM, RUT, histopathology, PCR, and UBT. conditions: Helicobacter Pylori Infection conditions: Peptic Ulcer Hemorrhage studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 135 type: ESTIMATED measure: The efficacy of CIM method for H. pylori detection measure: The advantages of CIM method for H. pylori detection sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Medicine Siriraj Hospital, Mahidol University city: Bangkok Noi state: Bangkok zip: 10700 country: Thailand lat: 13.76266 lon: 100.47798 hasResults: False
nctId: NCT06273371 id: DELISA2023 briefTitle: Tolerance and Growth Outcomes in Children Diagnosed With Cow's Milk Protein Allergy and Prescribed an Extensively Hydrolyzed Casein Formula (Damira 2000©) in Spain acronym: DELISA overallStatus: COMPLETED date: 2023-12-12 date: 2023-12-21 date: 2023-12-21 date: 2024-02-22 date: 2024-02-22 name: Lactalis class: INDUSTRY briefSummary: Damira 2000© is a 100% extensive casein hydrolysate (eHCF). It is formulated to help reverse growth retardation as a result of cow's milk proteins allergy (CMPA), to be well tolerated and to help improve symptoms.Damira 2000 is indicated for allergy/intolerance to cow's milk proteins, atopic dermatitis secondary to CMPA, intestinal malabsorption processes and prevention of allergy/intolerance to cow's milk proteins.The study aimed at evaluating the tolerance of Damira 2000 in a cohort of children with CMPA. conditions: Cow's Milk Protein Allergy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 61 type: ACTUAL name: Damira 2000 Infant formula measure: Tolerance measure: Weight measure: Height measure: Weight for height and BMI measure: Head circumference sex: ALL minimumAge: 0 Months maximumAge: 12 Months stdAges: CHILD facility: Hospital Quirónsalud de Córdoba city: Córdoba state: Andalucia country: Spain lat: 37.89155 lon: -4.77275 facility: H. Virgen del Rocío city: Sevilla state: Andalucia country: Spain lat: 37.38283 lon: -5.97317 facility: H. Virgen Macarena city: Sevilla state: Andalucia country: Spain lat: 37.38283 lon: -5.97317 facility: Instituto Hispalense de pediatría city: Sevilla state: Andalucia country: Spain lat: 37.38283 lon: -5.97317 facility: Hospital Materno infantil de Ourense city: Orense state: Galicia country: Spain lat: 42.33669 lon: -7.86407 facility: H. Clínico de Santiago city: Santiago De Compostela state: Galicia country: Spain lat: 42.88052 lon: -8.54569 facility: Clínica privada Dr. Romera city: Madrid country: Spain lat: 40.4165 lon: -3.70256 facility: Fundación Jiménez Día city: Madrid country: Spain lat: 40.4165 lon: -3.70256 hasResults: False
nctId: NCT06273358 id: Study Sleep Quality briefTitle: Preoperative Sleep Quality and Postoperative Delirium overallStatus: COMPLETED date: 2023-08-01 date: 2023-12-18 date: 2024-01-27 date: 2024-02-22 date: 2024-02-22 name: Konya City Hospital class: OTHER briefSummary: Background: Delirium is a neurocognitive illness that has lately been connected to sleep difficulties. It is a stressful condition. is still not fully understood. A poor sleep burden and its progress were investigated in this study to determine their correlations with the risk of delirium following surgical procedures.
Methods: Between August 1st and December 5th, 2023, 124 patients undergoing non-cardiac general anesthesia (mean age 63.68 ± 8.81 years \[SD\]; range 46-82 years) reported on their sleep characteristics. PSQI, 1- sleep duration, 2- sleep disturbance, 3- sleep latency, 4- daytime dysfunction resulting from sleepiness, 5- sleep efficiency, 6- overall sleep quality, and 7- usage of sleep medications were among these sleep characteristics. Seven component scores, ranging from 0 (no difficulty) to 3 (extreme difficulty), are obtained while assessing the PSQI. The global score ranges from 0 to 21 and is calculated by adding the component scores. Higher scores indicate poorer sleep quality. A three-day median follow-up time was used to analyze hospitalization records to gather data on new-onset delirium (n = 26). Approximately 124 people on average, with a mean. conditions: PREOPERATIVE SLEEP QUALITY ON POSTOPERATIVE DELIRIUM studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 150 type: ACTUAL measure: Sleep quality and delirium index measure: Preop. and postop. sleep quality index measure: Sleep quality and QR 15 score sex: ALL minimumAge: 45 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Yasin Tire city: Konya state: Meram zip: 42140 country: Turkey lat: 37.87135 lon: 32.48464 hasResults: False
nctId: NCT06273345 id: IOV-PR-1-2022-OLIGOS briefTitle: OLIGOS: Impact of Treatment on Primary Tumour in Patients With Newly Diagnosed Oligometastatic Neoplasia of the Prostate acronym: OLIGOS overallStatus: RECRUITING date: 2023-01-23 date: 2025-01 date: 2025-01 date: 2024-02-22 date: 2024-02-22 name: Istituto Oncologico Veneto IRCCS class: OTHER briefSummary: The proposed study consists of a multicentre prospective observational study involving patients with oligometastatic prostatic neoplasia defined according to CHAARTED criteria.
The aim of the study is the creation of a registry including patients with newly diagnosed OMPCa, belonging to the main urological centres in the Triveneto region, in order to evaluate the oncological outcomes and the impact on the quality of life of local treatment of the primary neoplasm (surgical or radiotherapy) in addition to systemic hormonal treatment (ADT as monotherapy or in combination with Docetaxel/androgen receptor signal inhibitors (ARTA)).
nctId: NCT06273332 id: AI surgery protocol briefTitle: Assessment of the Artifical Intelligence Assisted Registration Versus Conventional Point Based Registration on Cone Beam-computed Tomography (CBCT) With Heavy Metal Artifacts overallStatus: ACTIVE_NOT_RECRUITING date: 2023-12-20 date: 2024-01-20 date: 2024-02-25 date: 2024-02-22 date: 2024-02-22 name: Ain Shams University class: OTHER briefSummary: Our study investigates the accuracy and duration needed for 3D model registration using artifical intelligence (AI) assistance compared to conventional point-based registration. Manual segmentation of all cone beam computed tomography (CBCT) scans will be performed before the registration procedure. conditions: Registration Accuracy studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 16 type: ESTIMATED name: AI-assisted registration name: Point-based registration measure: Registration accuracy measure: Duration for registration sex: ALL minimumAge: 15 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Private maxillofacial digital lab city: Cairo country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06273319 id: 010656 briefTitle: The Effect of Oxygen Application With Double Nasal Cannula on Respiratory Complications overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-05-01 date: 2024-06-01 date: 2024-02-22 date: 2024-02-22 name: Inonu University class: OTHER briefSummary: To compare desaturation and respiratory complications by applying oxygen therapy with double nasal cannula to patients who are planned to undergo gastrointestinal endoscopy. conditions: Gastric Disease conditions: Gastric Distress studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: 2 whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 200 type: ESTIMATED name: OXYGEN THERAPY measure: Determination of the amount of oxygen to prevent the peripheral oxygen saturation of the patients from falling below 95% sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Inonu universitesi city: Malatya zip: 44050 country: Turkey lat: 38.35018 lon: 38.31667 hasResults: False
nctId: NCT06273306 id: HULP.PI-4519 id: PI22/00777 type: OTHER_GRANT domain: Fondo de investigaciones sanitarias.Instituto de Salud Carlos III briefTitle: Towards Telemonitoring in Immune-Mediated Inflammatory Diseases: Implementation of a Mixed Attention Model (IMIDOC) acronym: IMIDOC overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-12-31 date: 2026-12-31 date: 2024-02-22 date: 2024-02-22 name: Instituto de Investigación Hospital Universitario La Paz class: OTHER briefSummary: The main objective is to evaluate the implementation of a hybrid care model called the mixed attention model (MAM) in clinical practice and to evaluate whether its implementation improves clinical outcomes compared to conventional follow-up.
This is a multicenter prospective observational study involving 360 patients with rheumatoid arthritis (RA) and Spondylarthritis (SpA) from five Spanish Hospitals. Patients will be followed-up by the MAM protocol, which is a care model that incorporates the use of digital tool consisting of a mobile application (App) that patients can use at home and that professionals can review asynchronously to detect incidents and to follow their patients; clinical evolution between face-to-face visits. Another group of patients, whose follow-up will be conducted in accordance with a traditional face-to-face care model, will be assessed as the control group. Sociodemographic characteristics, treatments, laboratory parameters, assessment of tender and swollen joints, visual analogue scale for pain and electronic patient reported outcome reports (ePROs) will be collected for all subjects. In the MAM group, these items will be self-assessed both by the mobile App and during face-to-face visits with rheumatologist, who will do the same for patients included in the traditional care model. Patients will be able to report any incidence related to their disease or treatment through the mobile App. conditions: Telemedicine conditions: Telehealth conditions: eHealth conditions: Rheumatic Diseases conditions: Arthritis, Rheumatoid conditions: Spondylarthritis studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 360 type: ESTIMATED name: IMIDOC measure: To assess the primary objective, composite endpoints that consider the viability, adherence and degree of satisfaction of the MAM are included measure: To identify features associated with adherence to follow-up through the MAM. sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06273293 id: EPIC35-PROMETEUS briefTitle: Postprocedural Contrast Mediated FFR Plus Intracoronary Infusion of Nitroglycerin in Multivessel Patients (PROMETEUS TRIAL) overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2025-01-20 date: 2026-01-20 date: 2024-02-22 date: 2024-03-13 name: Fundación EPIC class: OTHER briefSummary: the use of pressure wires is the standar of care to evaluate angiographically intermediate coronary lesions, however, limitations in the management of these type of lesions continue to be a challenge for the interventional cardiologist. The use of FFR has some limitations such as the use of adenosine due to its cost, adverse effects (e.g. transient atrioventricular block, angina, headache, etc.), time consuming and some relative contraindications for its use. In this sense, in recent years new rest indices (iFR, RFR, dPR) and hyperemic indices without adenosine (cFFR-NTG, Pd/Pa-NTG or cFFR) have been developed, demonstrating an improvement in terms of outcomes with its use, so they can also be used as a tool to guide us to plan our strategy. These new indices, particularly the cFFR-NTG, are simpler, at least as safe and have an excellent correlation with the FFR with adenosine in the assessment of intermediate coronary lesions.
In recent years, functional assessment after intervention has also been increasingly implemented, which, like intracoronary imaging, can make us change our attitude and correlate with the prognosis. The lower implementation of this practice, especially in multivessel patients, may result from having to lose the position of the wire to check equalization, difficulty in crossing the wire, wear/breakage of the material after diagnosis (2-3 vessels), use more time and contrast, etc. These problems could be reduced, at least partially, with the use of the workhorse coronary guidewire pressure microcatheter to measure post-PCI functional assessment. Although the usefulness of post-PCI FFR has been demonstrated, there is no clearly established cut-off value (0.84-0.96) and it seems that in reality the values are a continuum of risk so that the higher the value, the better the prognosis . Furthermore, other simpler indices such as rest or hyperemic indices without adenosine have not been correlated with FFR in post-PCI.
The purpose of this study is to evaluate the correlation between cFFR-NTG and other indices taking FFR as a reference in multivessel patients after undergoing intervention. Establish cut-off points and correlate it with adverse cardiovascular events (MACE) in a 1-year clinical follow-up. conditions: Coronary Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 150 type: ESTIMATED name: Fractional Flow Reserve measure: Agreement between cFFR+NTG and FFR measure: SAFETY: MACE measure: Agreement between Pd/Pa or dPR and FFR measure: Cut-off point for cFFR+NTG post-ICP measure: Evaluate the change in strategy that the measurement of FFR values ≤0.90 post-PCI measure: Cardiac death measure: Cardiovascular death measure: Acute myocardial infarction of the lesion treated/functionally evaluated measure: Acute myocardial infarction from any lesion measure: Need for revascularization of the lesion treated/functionally evaluated measure: Need for revascularization of any lesion sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06273280 id: Z-2023025 briefTitle: Renal-based Optimization of QUADruple Therapy in Patients With Heart Failure With Reduced Ejection Fraction. acronym: ReQUAD-HF overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-14 date: 2025-12 date: 2026-03 date: 2024-02-22 date: 2024-02-28 name: Ziekenhuis Oost-Limburg class: OTHER name: King Baudouin Foundation briefSummary: The goal of this clinical trial is to evaluate guideline-directed medical therapy (GDMT) up-titration in patients with heart failure with reduced ejection fraction.The main question it aims to answer is the improvement in prescription rate and dose uptitration of quadruple GDMT in patients with HFrEF, assessed by a weighed composite score.