hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06312254 id: N-20230071 briefTitle: Pharmacological Modulation of Peripheral Nerve Excitability overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-02 date: 2025-08 date: 2024-03-15 date: 2024-03-15 name: Aalborg University class: OTHER briefSummary: The present project is a human experimental study. The aim is to assess the pharmacologically modulated excitability of peripheral sensory nerves with a human experimental model.
The study measures the excitability of peripheral sensory nerves before and after application of different topical drugs (lidocaine (5%), phenytoin (10%),mepyramine (2%) and placebo). conditions: Peripheral Neuropathy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: DOUBLE maskingDescription: Participant and investigator/project involved personal is blinded to which cream is applied. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 20 type: ESTIMATED name: Topical lidocaine 5% name: Topical Phenytoin 10% name: Topical Mepyramine 2% name: Topical Placebo measure: Change in PTT-value sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Center for Neuroplasticity and Pain city: Aalborg country: Denmark lat: 57.048 lon: 9.9187 hasResults: False
nctId: NCT06312241 id: MCT-Silver BeWell briefTitle: Metacognitive Training-Silver BeWell in Older Adults overallStatus: RECRUITING date: 2024-02-21 date: 2025-08 date: 2025-12 date: 2024-03-15 date: 2024-03-15 name: Universitätsklinikum Hamburg-Eppendorf class: OTHER briefSummary: The present study seeks to examine the feasibility, acceptance and efficacy of Metacognitive Training-Silver (MCT-Silver) BeWell among older adults (ages 60 years and older) delivered in a community setting (e.g., social-psychiatric community center, nursing homes, etc.). conditions: Depressive Symptoms conditions: Well-Being, Psychological studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: Metacognitive Training-Silver BeWell measure: Number of sessions attended measure: Participants' appraisal of the training measure: Negative effects questionnaire (NEQ) measure: Depression (Beck Depression Inventory - II) measure: Dysfunctional beliefs (18-item Dysfunctional Attitudes Scale) measure: Mental Well-Being (Warwick-Edinburgh Mental Well-being Scale) measure: Resilience (Resilience Scale) measure: Rumination (Ruminative Responses Scale) measure: Loneliness (UCLA Loneliness scale) measure: Self-rated health (EQ5D5L Visual Analog Scale ) measure: Session-specific effects sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Medical Center Hamburg-Eppendorf status: RECRUITING city: Hamburg zip: 20246 country: Germany name: Brooke Viertel, PhD role: CONTACT phone: 040 7410 24014 email: b.viertel@uke.de lat: 53.57532 lon: 10.01534 hasResults: False
nctId: NCT06312228 id: 2023/05 briefTitle: The Effect of the Helper Skin Tap Technique and Buzzy® During Vaccination overallStatus: COMPLETED date: 2023-05-01 date: 2023-10-02 date: 2023-10-02 date: 2024-03-15 date: 2024-03-15 name: Tarsus University class: OTHER briefSummary: Aim: This randomised controlled experimental study was conducted to determine the effect of Helfer Skin Tap Technique and Buzzy® application on the pain level during measles-mumps-rubella-mumps (MMR) vaccine injection in 4-year-old children.Method: The study was a randomised controlled experimental study. The sample of the study consisted of 96 children (buzzy: 32, helfer skin tap: 32, control: 32) who underwent MMR vaccination at Bakırköy Family Health Centre No. 9 between May 2023 and October 2023. Data Collection Form, Wong-Baker pain scale, Fear scale and Buzzy® device were used as data collection tools. Buzzy® and Helfer skin tap technique were applied to the children in the intervention group before and after the vaccine injection, while routine vaccine injection was applied to the children in the control group. Children's pain and fear responses were evaluated by the nurse and parents before and after vaccine injection, and physiological parameters were evaluated by the nurse before and after vaccine injection. conditions: Child, Only studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE whoMasked: PARTICIPANT count: 96 type: ACTUAL name: Helfer Skin Tap name: Buzzy measure: Child Information Form measure: Wong-Baker Scale (Pain Facial Expression Scale) measure: Child Fear Scale sex: ALL minimumAge: 4 Years maximumAge: 4 Years stdAges: CHILD facility: Tarsus University city: Mersin zip: 33400 country: Turkey lat: 36.79526 lon: 34.61792 hasResults: False
nctId: NCT06312215 id: 1763831 briefTitle: Effect Of Open And Closed System Peripheral Catheters Used In Pediatric Services overallStatus: COMPLETED date: 2023-05-26 date: 2023-10-02 date: 2023-10-02 date: 2024-03-15 date: 2024-03-15 name: Tarsus University class: OTHER briefSummary: The study was conducted as a randomized controlled experimental research to examine the effects of open and closed system peripheral catheters on the success of insertion, duration of stay, and development of complications in children aged 1-18 years in pediatric services. The population of the study consisted of children admitted to the Pediatric Services of the Istanbul Faculty of Medicine, and the sample included a total of N=80 children who met the sample criteria and underwent catheter insertion between May 2023 and October 2023. The sample was divided into two groups: closed system peripheral venous catheter group (n=40) and open system peripheral venous catheter group (n=40). The data of the study were collected using a Data Collection Form, Peripheral Venous Catheter Monitoring Form, Visual Infusion Phlebitis Detection Scale, and Pediatric Peripheral Intravenous Infiltration Scale conditions: Child, Only conditions: Catheter Infection conditions: Catheter Complications studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE whoMasked: PARTICIPANT count: 80 type: ACTUAL name: Closed-system catheter measure: Patient Identification Form measure: Daily Monitoring Form measure: Visual Infusion Phlebitis Assessment Scale, Staging Key - Peripheral IV'sVIPAS measure: Pediatric peripheral intravenous infiltration assessment tool sex: ALL minimumAge: 1 Month maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Tarsus University city: Mersin zip: 33400 country: Turkey lat: 36.79526 lon: 34.61792 hasResults: False
nctId: NCT06312202 id: DROWN_HARBOUR briefTitle: Drowning Incidents in Danish Harbours acronym: DROWN_HARBOR overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-31 date: 2024-12-31 date: 2024-03-15 date: 2024-03-25 name: Prehospital Center, Region Zealand class: OTHER briefSummary: A recent study reported significantly increased mortality from drowning-related out-of-hospital cardiac arrest in Danish harbours compared to other public places (e.g., public pools, coastlines, and lakes). Accurate and reliable data are necessary before establishing specific educational, preventative, rescue, or treatment strategies to reduce the number of drowning incidents in Danish harbours and improve survival. Therefore, it is essential to characterise drowning incidents in Danish harbours and analyse risk factors associated with fatal drowning. conditions: Drowning conditions: Drown conditions: Drowning; Anoxia conditions: Drowning, Near conditions: Drowning; Asphyxia conditions: Drowning and Nonfatal Submersion conditions: Drowning or Immersion of Unknown Intent conditions: Drowning and Submersion, Undetermined Intent conditions: Drowning and Submersion While in Natural Water conditions: Drowning and Submersion Due to Sailboat Sinking conditions: Drowning and Submersion Due to Fall Off Ship studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 400 type: ESTIMATED name: Drowning measure: Yearly incidence of drowning incidents measure: Fatal to non-fatal drowning ratio measure: Assess risk factors associated with 30-day mortality sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Prehospital Center city: Næstved state: Region Zealand zip: 4700 country: Denmark lat: 55.22992 lon: 11.76092 hasResults: False
nctId: NCT06312189 id: NBI-98854-HD3022 briefTitle: Long-term Study to Evaluate Safety and Tolerability of Valbenazine in Participants With Chorea Associated With Huntington Disease in Canada overallStatus: ENROLLING_BY_INVITATION date: 2024-03 date: 2026-03 date: 2026-03 date: 2024-03-15 date: 2024-03-15 name: Neurocrine Biosciences class: INDUSTRY briefSummary: This study will evaluate long-term safety and tolerability of valbenazine in participants with chorea associated with Huntington Disease (HD) who participated in Study NBI-98854-HD3006 (NCT04400331) in Canada. conditions: Chorea, Huntington studyType: INTERVENTIONAL phases: PHASE3 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 7 type: ESTIMATED name: Valbenazine measure: Number of Participants with Treatment-Emergent Adverse Events (TEAEs) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Neurocrine Clinical Site city: Vancouver state: British Columbia zip: V6T 2B5 country: Canada lat: 49.24966 lon: -123.11934 facility: Neurocrine Clinical Site city: Ottawa state: Ontario zip: K1Y 4E9 country: Canada lat: 45.41117 lon: -75.69812 facility: Neurocrine Clinical Site city: Toronto state: Ontario zip: MK2 1E1 country: Canada lat: 43.70011 lon: -79.4163 hasResults: False
nctId: NCT06312176 id: 2870-010 id: MK-2870-010 type: OTHER domain: Merck id: 2023-504918-29 type: REGISTRY domain: EU CT id: U1111-1289-8119 type: OTHER domain: UTN briefTitle: A Study of MK-2870 as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010) overallStatus: RECRUITING date: 2024-04-13 date: 2027-07-11 date: 2031-04-12 date: 2024-03-15 date: 2024-04-05 name: Merck Sharp & Dohme LLC class: INDUSTRY briefSummary: The purpose of this study is to compare MK-2870 as a single agent, and in combination with pembrolizumab, versus Treatment of Physician's Choice (TPC) in participants with hormone receptor positive/human epidermal growth factor receptor-2 negative (HR+/HER2-) unresectable locally advanced, or metastatic, breast cancer.
The primary hypotheses are that MK-2870 as a single agent and MK-2870 plus pembrolizumab are superior to TPC with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) by blinded independent central review (BICR) in all participants. conditions: Breast Neoplasms studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 1200 type: ESTIMATED name: MK-2870 name: Pembrolizumab name: Paclitaxel name: Nab-paclitaxel name: Capecitabine name: Liposomal doxorubicin measure: Progression-Free Survival (PFS) (MK-2870 versus treatment of physician's choice [TPC]; MK-2870 + pembrolizumab versus TPC) measure: Overall Survival (OS) measure: Progression-Free Survival (PFS) (MK-2870 + pembrolizumab versus MK-2870) measure: Objective Response Rate (ORR) measure: Duration of Response (DOR) measure: Change from baseline in global health status/quality of life scores, on the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) measure: Change from baseline in physical functioning score, on the EORTC QLQ-C30 measure: Change from baseline in emotional functioning score, on the EORTC QLQ-C30 measure: Change from baseline in fatigue score, on the EORTC QLQ-C30 measure: Change from baseline in diarrhea score, on the EORTC QLQ-C30 measure: Time to first Deterioration (TTD) in global health status/quality of life scores, on the EORTC QLQ-C30 measure: TTD in physical functioning score, on the EORTC QLQ-C30 measure: TTD in emotional functioning score, on the EORTC QLQ-C30 measure: TTD in fatigue score, on the EORTC QLQ-C30 measure: TTD in diarrhea score, on the EORTC QLQ-C30 measure: Number of participants who experience one or more adverse events (AEs) measure: Number of participants who discontinue study treatment due to an AE sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Rambam Health Care Campus-Oncology Division ( Site 1452) status: RECRUITING city: Haifa zip: 3109601 country: Israel name: Study Coordinator role: CONTACT phone: 972-4-777-6700 lat: 32.81841 lon: 34.9885 hasResults: False
nctId: NCT06312163 id: EHRD1001 briefTitle: Validation of Innovative Scheimpflug Topography Derived RGP Contact Lens Designs In Optometry Network acronym: VISION overallStatus: COMPLETED date: 2022-06-06 date: 2023-12-15 date: 2023-12-15 date: 2024-03-15 date: 2024-03-15 name: Moorfields Eye Hospital NHS Foundation Trust class: OTHER briefSummary: The goal of this Prospective, single-site, cohort study is to validate rigid gas permeable corneal contact lens (RGP) designs for keratoconus derived from combining the data from corneal topography scans and contact lenses ordered in patients with keratoconus (KC) attending a UK tertiary NHS Hospital contact lens clinic. The main questions it aims to answer are:
• Visit 1: Pentacam topography scans and optimal 'virtual' lens selection will take place. • • Visit 2: Participants are fitted with 4 contact lenses (i) the optimal lens design as specified by the virtual fitting module, (ii) a contact lens with a clinically significant step flatter AEL (iii) a contact lens steeper in axial edge lift (AEL) (iv) the participant's own contact lens.
WP3. Clinicians not involved in the study will be invited to examine a demo version of the virtual fitting module and complete the validated system usability scale tool. conditions: Keratoconus studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 120 type: ACTUAL name: The contact lens to be investigated in this study (Scheimpflug topography derived corneal RGP contact lens design). A CE (UKCA) marked class 2 medical devices. measure: Rigid gas permeable contact lens fit measure: The changes in contact lens fit from increased and decreased Axial Edge lift measure: Best corrected Visual Acuity measure: Clinician Usability Assessment sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Moorfields Eye Hospital NHS Foundation Trust city: London zip: EC1V 2PD country: United Kingdom lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06312150 id: BETA 3 2019 briefTitle: Role of Tumoral Biomarker B3 Adrenergic Receptor in Paediatric Solid Tumours overallStatus: RECRUITING date: 2019-12-17 date: 2025-09 date: 2025-12 date: 2024-03-15 date: 2024-03-18 name: Meyer Children's Hospital IRCCS class: OTHER briefSummary: Childhood cancers are the third leading cause of death among children between the ages of 1 and 4, and the second leading cause of death among children aged 5-14 years. Biologically, it has been demonstrated that tumour aggressiveness and invasive capacity are caused by genetic modifications and cellular microenvironmental factors in a sequential and multifactorial process. The search for genetic alterations, proteins, or entire intracellular signalling pathways involved in the process of carcinogenesis and metastatisation is always evolving in order to identify new prognostic factors or potential therapeutic targets. In recent years, β-adrenergic receptors (β-ARs) have been associated with tumour progression.
This is a multicentre biological samples study which main aim is to evaluate the β3 receptor expression in the peripheral blood of patients with solid tumours compared to a healthy control group. The biological samples collected during the study are: peripheral blood sample, bone marrow aspirate and fresh or fresh paraffin biopsy tumour. conditions: Tumor studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: NONE count: 60 type: ESTIMATED name: Analysis of peripheral blood (control group) name: Analysis of biological sample (Substudy-solid neoplasms) name: Analysis of biological sample (substudy-leukaemia patients) measure: Evaluation of β3 receptor expression in the peripheral blood, bone marrow and bioptic samples of patients with solid tumours compared to a healthy control group measure: Assessment of oxidative stress in peripheral blood samples from enrolled patients measure: Evaluation of the role of the β3 receptor in apoptosis resistance (substudy) sex: ALL minimumAge: 1 Day maximumAge: 75 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Ospedale San Donato di Arezzo status: NOT_YET_RECRUITING city: Arezzo country: Italy name: Carlo Milandri role: CONTACT email: carlo.milandri@uslsudest.toscana.it lat: 43.46276 lon: 11.88068 facility: Meyer Children's Hospital IRCCS status: RECRUITING city: Florence country: Italy name: Annalisa Tondo role: CONTACT phone: 0555662489 email: annalisa.tondo@meyer.it lat: 43.77925 lon: 11.24626 facility: Azienda Ospedaliera Pisana status: ACTIVE_NOT_RECRUITING city: Pisa country: Italy lat: 43.70853 lon: 10.4036 hasResults: False
nctId: NCT06312111 id: 62/2021 briefTitle: Physical Activity and Various Aspects of Quality of Life in Patients With Pulmonary Arterial Hypertension (Ph-PAH) acronym: PhA-PAH overallStatus: COMPLETED date: 2021-04-22 date: 2021-07-15 date: 2022-07-17 date: 2024-03-15 date: 2024-03-15 name: Centre of Postgraduate Medical Education class: OTHER briefSummary: Evaluate whether education, a simple doctor's recommendation to increase physical activity in inactive patients, and self-monitoring of physical activity using a pedometer were effective and beneficial for patients with pulmonary arterial hypertension (PAH) conditions: Pulmonary Arterial Hypertension conditions: Physical Inactivity studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 48 type: ACTUAL name: recommendation to increase physical activity measure: Number of steps per day measure: Change in 6-minute walk distance measure: Change in quality of life (SF-36) measure: Change in the hospital anxiety and depression scale (HADS) measure: Change in the acceptance of illness (AIS) measure: Change in N-Terminal Pro-B-Type Natriuretic Peptide level (NT-proBNP) measure: Change in World Health Organization (WHO) functional Class recorded by investigator in conjunction with the 6MWD measure: Compliance with counting steps sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, European Health Centre, Otwock, Centre of Postgraduate Medical Education city: Otwock state: Borowa 14/18 zip: 05-400 country: Poland lat: 52.10577 lon: 21.26129 hasResults: False
nctId: NCT06312098 id: KC21RISI0576 briefTitle: Perioperative Factors and Living Donor Liver Transplantation overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-06-01 date: 2024-07-01 date: 2024-03-15 date: 2024-03-18 name: Min Suk Chae class: OTHER briefSummary: Liver transplant surgery is one of the treatments provided to patients suffering from end-stage liver disease, and has a successful treatment prognosis. However, it is clear that patient management before, during, and after surgery is a difficult task for medical staff due to the complex clinical and pathological problems of end-stage liver disease. Moreover, the complex surgical technique of the liver transplant surgery itself and the severe hemodynamic fluctuations and multi-organ dysfunction that patients experience during the surgery have been shown to have a tremendous impact on the patient's prognosis after surgery.
A study on which clinical, laboratory, and hemodynamic factors experienced by patients during the perioperative period, including before, during, and after surgery, affect the survival rate of patients and transplanted organs. will definitely be helpful in the treatment of patients suffering from end-stage liver disease. conditions: Liver Transplant Disorder studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 533 type: ESTIMATED name: remote ischemic preconditioning (RIPC) measure: Incidence of postreperfusion syndrome sex: ALL minimumAge: 19 Years maximumAge: 79 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06312085 id: EF_5301_V1.0_CIP briefTitle: A Study to Assess the Clinical Success of Root Canal Treatment Using Novel Obturation Material. overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-12 date: 2026-12 date: 2024-03-15 date: 2024-03-15 name: Lumendo AG class: INDUSTRY name: Avania briefSummary: The goal of this study is prospective, single-arm, non-randomized controlled trial to test the effectiveness, safety and performance of a novel dental obturation material. The main question sit answers is
The participants requiring root canal treatment will be treated with obturated using Endofill material and post-treatment follow-up vistis will be conducted for 1 year. This is a single-arm study with no comparison groups. conditions: Endodontic Treatment studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 63 type: ESTIMATED name: Endofill measure: Effectiveness of root canal treatment using Endofill measure: Safety of root canal treatment using endofill sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Medipol University city: Istanbul country: Turkey name: Tan Firat Eyuboglu role: CONTACT phone: +905304636059 email: tfeyuboglu@yahoo.com lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06312072 id: 23-019 briefTitle: Understanding Risk Factors for Progressive Chronic Kidney Disease in Malawi overallStatus: RECRUITING date: 2024-02-14 date: 2025-12 date: 2025-12 date: 2024-03-15 date: 2024-03-15 name: Liverpool School of Tropical Medicine class: OTHER name: Wellcome Trust name: Malawi Epidemiology and Intervention Research Unit name: London School of Hygiene and Tropical Medicine name: University of Glasgow name: Malawi-Liverpool-Wellcome Trust Clinical Research Programme briefSummary: Worldwide, the number of people living with long-term health conditions, including chronic kidney disease (CKD), is increasing. CKD is usually asymptomatic in early stages but can progress to advanced disease, including kidney failure, causing significant morbidity and mortality.