hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06290908 id: TF2018-001-01 briefTitle: RPE-P/TLIF for Lumbar Spinal Stenosis With Instability overallStatus: COMPLETED date: 2018-09-04 date: 2022-04-30 date: 2024-02-01 date: 2024-03-04 date: 2024-03-04 name: Wen-xi Sun class: OTHER name: Guangdong Provincial Hospital of Traditional Chinese Medicine briefSummary: Objective To analyze the effectiveness and safety of robot-assisted percutaneous endoscopic posterior/transforaminal lumbar interbody fusion (RPE-P/TLIF) in the treatment of lumbar spinal stenosis with instability. Methods A single-center prospective study from September 2018 to April 2022, patients with lumbar spinal stenosis and instability who met the inclusion and exclusion criteria were treated with RPE-P/TLIF. Pain visual analog scale (VAS) was used to evaluate the degree of low back pain and lower limb pain before operation, 1 month, 6 months, 1 year after operation and at the final follow-up, and the Oswestry disability index (ODI) was used to evaluate the degree of lumbar spinal function. At the last follow-up, MacNab criteria were used to evaluate the clinical efficacy. Imaging evaluation included the measurement of intervertebral space height, lumbar physiological curvature, fusion rate and pedicle screw accuracy by preoperative and lateral X-ray films. conditions: Spinal Stenosis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 26 type: ACTUAL name: RPE-P/TLIF measure: Pain visual analog scale (VAS) measure: Oswestry disability index (ODI) measure: MacNab criteria measure: intervertebral space height measure: lumbar physiological curvature measure: fusion rate measure: pedicle screw accuracy sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Guangdong Provincial Hospital of Traditional Chinese Medicine city: Guangzhou country: China lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06290895 id: 3465 briefTitle: Artificial Oocyte Activation overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-22 date: 2024-12-31 date: 2025-02-19 date: 2024-03-04 date: 2024-03-04 name: Clinique Ovo class: INDUSTRY briefSummary: Studies reported that calcium signal deficiency or insufficiency during oocyte activation are related with embryo arrest and blastocyst quality. The utilization of Artificial Oocyte Activation (AOA) is safe and does not increase birth defects, cognition, language and motor skills. AOA is the first line of treatment in patients with globozoospermia (round headed spermatozoa). Poor responders in in-vitro fertilization (IVF) cycles represent a major challenge for fertility specialists and comprises about 10-15% of patients undergoing controlled ovarian hyperstimulation. The absence of synergy between the oocyte and sperm leads to a negative impact on oocyte activation. The European Society of Human and REproduction (ESHRE) recommends AOA in cases with failed fertilization/ low fertilization. conditions: Infertility conditions: Ovarian Insufficiency studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 54 type: ACTUAL name: women having had a second IVF cycle with AOA measure: Blastocyst rate sex: FEMALE minimumAge: 18 Years maximumAge: 42 Years stdAges: ADULT facility: Clinique Ovo city: Montréal state: Quebec zip: H4P 2S4 country: Canada lat: 45.50884 lon: -73.58781 hasResults: False
nctId: NCT06290882 id: ERMA trial briefTitle: Endoscopic Versus Robotic Myotomy for Treatment of Achalasia acronym: ERMA overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-01 date: 2026-01-31 date: 2027-01-01 date: 2024-03-04 date: 2024-03-05 name: Germans Trias i Pujol Hospital class: OTHER briefSummary: Achalasia is a primary esophageal motor disorder of unknown etiology characterized by degeneration of the myenteric plexus, resulting in impaired relaxation of the esophagogastric junction (EGJ), along with loss of peristalsis in the esophageal body. The standard criteria for diagnosing achalasia is high-resolution esophageal manometry, which shows incomplete relaxation of the EGJ along with absence of esophageal body peristalsis. These anomalies usually cause dysphagia and regurgitation as the main symptoms of this pathology. Different treatment options have been described for this pathology, with pneumatic dilation (PD) and myotomy being considered first-line, whether surgical (laparoscopic Heller myotomy, LHM) or endoscopic (peroral endoscopic myotomy, POEM). The arrival of POEM as a less invasive alternative for the treatment of achalasia has revolutionized expectations to the point that it has become a routine procedure in many centers around the world. In recent years, a large amount of data examining the effectiveness of POEM have appeared, including several meta-analyses. The success rate of POEM in prospective cohorts has been greater than 90%. Two randomized studies have been published comparing POEM with LHM, providing a framework to evaluate the comparative efficacy and safety of these two interventions and to determine which should be first-line for the treatment of these patients. According to these data, it seems that the two procedures offer the same clinical results in the medium term. On the other hand, in recent years, there has been a growing expansion of the application of robot-assisted technology. Robotic Heller myotomy (RHM) has been proposed as an alternative minimally invasive approach to traditional laparoscopy with a lower complication rate. Based on the evidence, POEM and RHM could have comparable results in short term, but there is no clear certainty about the results in medium-long term. Likewise, there is a lack of studies that confirm postoperative reflux results in both procedures.
The purpose of the study is to evaluate the clinical and quality of life results of the RHM and compare them with the results of POEM in treatment of achalasia. conditions: Achalasia Cardia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized controlled trial primaryPurpose: TREATMENT masking: NONE count: 144 type: ACTUAL name: Robotic Heller Myotomy name: Peroral Endoscopic Myotomy measure: Eckhard symptom scores measure: GERD-Q score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Elisenda Garsot Savall city: Badalona state: Barcelona zip: 08016 country: Spain lat: 41.45004 lon: 2.24741 hasResults: False
nctId: NCT06290869 id: STUDY00006070 briefTitle: Tobacco Education and Lung Health Study (TEAL) acronym: TEAL overallStatus: RECRUITING date: 2024-02-22 date: 2026-02 date: 2026-04 date: 2024-03-04 date: 2024-03-06 name: Georgetown University class: OTHER briefSummary: Primary Objective To compare two smoking cessation interventions among individuals undergoing lung cancer screening. Primary outcomes are: 3-month self-reported abstinence from cigarettes and 6-month self-reported and bioverified abstinence from cigarettes.
Secondary Objectives 1) To evaluate reach and engagement overall and by subgroup (e.g., race and ethnicity, underinsured, readiness to quit). 2) To conduct an economic analysis to evaluate intervention costs from the health system perspective. conditions: Smoking Cessation studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 1188 type: ESTIMATED name: Phone-based Tobacco Treatment, Nicotine Replacement, and Stepped Care Intervention name: E-Referral to the Tobacco Quitline measure: Biochemically verified smoking abstinence- MHS vs. QL-E arms measure: Biochemically verified smoking abstinence--continued MHS arm vs Stepped Care measure: self-reported smoking status measure: cigarettes per day measure: readiness to quit measure: Patient reach and patient engagement measure: Costs per arm from the health system perspective sex: ALL minimumAge: 50 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Georgetown University Medical Center status: RECRUITING city: Washington state: District of Columbia zip: 20007 country: United States name: Kathryn L Taylor, PhD role: CONTACT phone: 202-215-9402 email: taylorkl@georgetown.edu lat: 38.89511 lon: -77.03637 hasResults: False
nctId: NCT06290856 id: 651397 briefTitle: Clinical Utility of Selected Circulating Tumor DNA Assays in Patients With Advanced Malignancy overallStatus: RECRUITING date: 2024-01-15 date: 2025-12-15 date: 2025-12-15 date: 2024-03-04 date: 2024-03-07 name: Oslo University Hospital class: OTHER briefSummary: Circulating tumor DNA assays are becoming relevant for routine diagnostics, but many related aspects are yet unresolved. With this project, the investigators aim to develop pragmatic molecular diagnostic pathways of liquid biopsies relevant in advanced gastrointestinal malignancies with focus on clinical utility and sensible use of resources. They want to evaluate the ctDNA assays on a fully automated "low-cost" multiplex platform which is already implemented in routine molecular diagnostics of solid biopsies. The project will evaluate to what extent these ctDNA assays are relevant for clinical decision-making. conditions: Metastatic Colorectal Cancer conditions: Pancreas Adenocarcinoma conditions: Cholangiocarcinoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Multiplex PCR-test for circulating tumor DNA measure: Clinical validity of ctDNA tests measure: Resources needed for ctDNA assays in routine diagnostics sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Oslo university Hospital status: RECRUITING city: Oslo country: Norway name: Ragnhild Nome, MD, PhD role: CONTACT lat: 59.91273 lon: 10.74609 hasResults: False
nctId: NCT06290843 id: AWFiS/2024_1_PE briefTitle: Analysis of Body Balance Parameters in Children With Idiopathic Scoliosis overallStatus: NOT_YET_RECRUITING date: 2024-04-05 date: 2024-05-30 date: 2024-05-30 date: 2024-03-04 date: 2024-04-04 name: Gdansk University of Physical Education and Sport class: OTHER briefSummary: The aim of the study is to compare body balance parameters assessed using the AMTI dynamometric platform in children with idiopathic scoliosis (with and without Schroth therapy) compared to control group. conditions: Idiopathic Scoliosis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: Schroth method measure: Analysis of body balance on the AMTI force platform measure: Analysis of body balance on the AMTI force platform measure: Analysis of body balance on the AMTI force platform measure: Analysis of body balance on the AMTI force platform measure: Photographic analysis of body posture measure: Analysis of x-ray in the frontal plane measure: Analysis of x-ray in the frontal plane measure: Analysis of x-ray in the frontal plane measure: Analysis of x-ray in the frontal plane measure: Analysis of x-ray in the sagittal plane measure: Analysis of x-ray in the sagittal plane sex: FEMALE minimumAge: 10 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Gdansk University of Physical Education and Sport city: Gdańsk state: Pomorskie zip: 80-336 country: Poland lat: 54.35205 lon: 18.64637 hasResults: False
nctId: NCT06290830 id: OMUŞükranBaşgöl01 briefTitle: Abdominal Massage and Kegel Exercises on Constipation and Quality of Life in Female Students overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-05-31 date: 2024-06-01 date: 2024-03-04 date: 2024-03-12 name: Ondokuz Mayıs University class: OTHER briefSummary: In this prospective, randomized controlled study, n=140 female students with functional constipation studying at two universities Faculty of Health Sciences and meeting the Rome-IV Diagnostic Criteria for Constipation will be included in the study. Between 15.03.2024 and 31.05.2024, n=140 (35=control group, 35=kegel exercise group, 35=abdominal exercise group, 35=abdominal and kegel exercise group) volunteered to participate in the study. Female students with functional constipation will be randomly divided into four groups as intervention and control groups. Personal Information Form", "Bristol Stool Scale", "Constipation Severity Scale", and "Patient Assessment of Constipation Quality of Life Questionnaire" will be used in this study. The scales will be used in the research two times: pre and post-test (scales were reassessed at the end of the study after the exercise intervention). Descriptive statistics, Pearson, and Spearman's correlation analyses will be used in the analysis of research data. conditions: Functional Constipation conditions: Constipation conditions: Quality of Life studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 140 type: ESTIMATED name: Abdominal massage group name: Kegel Exercises group name: Both abdominal massage and kegel exercises to gether measure: Constipation severity change measure: Quality of Life change measure: Bristol stool form score change sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT hasResults: False
nctId: NCT06290817 id: 2023-0724 briefTitle: Orelabrutinib Combined With R-CDOP for DLBCL Patients With High-risk of CNS Relapse Defined by CNS-IPI overallStatus: RECRUITING date: 2023-03-30 date: 2025-03-30 date: 2026-03-20 date: 2024-03-04 date: 2024-03-04 name: Second Affiliated Hospital, School of Medicine, Zhejiang University class: OTHER name: Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University name: Huizhou Municipal Central Hospital name: Ningbo Medical Center Lihuili Hospital name: Affiliated Hospital of Jiaxing University name: The Second Affiliated Hospital of Jiaxing University briefSummary: This is a prospective, multicenter, single-arm clinical study on the treatment of newly diagnosed diffuse large B-cell lymphoma with high-risk of CNS relapse defined by CNS-IPI using Orelabrutinib in combination with R-CDOP regimen. conditions: Diffuse Large B-cell Lymphoma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 62 type: ESTIMATED name: Orelabrutinib combined with R-CDOP regimen measure: 2-year central nervous system relapse rate measure: Complete Response Rate measure: Overall Response Rate (ORR) measure: 2-year Overall survival (OS) rate measure: 1-year Overall survival (OS) rate measure: 2-year progression-free survival (PFS) rate measure: 1-year progression-free survival (PFS) rate measure: Occurrence of hematologic adverse events and non-hematologic adverse events according to CTCAE V4.03 measure: Occurrence of adverse events and serious adverse events according to CTCAE V4.03 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Second Affiliated Hospital, School of Medicine, Zhejiang University status: RECRUITING city: Zhejiang state: Zhejiang country: China name: Wenbin Qian role: CONTACT name: Xibin Xiao role: SUB_INVESTIGATOR facility: Huzhou Central Hospital status: RECRUITING city: Huzhou country: China name: Lihong Shou role: CONTACT phone: 13362216921 email: SLH077@126.COM lat: 30.8703 lon: 120.0933 facility: Affiliated hospital of Jiaxing University , the First Hospital of Jiaxing status: RECRUITING city: Jiaxing country: China name: Hui Zeng role: CONTACT phone: 13957330440 email: zhwuhqn@163.com lat: 30.7522 lon: 120.75 facility: Affiliated hospital of Jiaxing University , the Second Hospital of Jiaxing status: RECRUITING city: Jiaxing country: China name: Beili Hu role: CONTACT phone: 0573-82080930 email: 87718916@qq.com lat: 30.7522 lon: 120.75 facility: Ningbo Medical Center LiHuili Hospital status: RECRUITING city: Ningbo country: China name: Jing Le role: CONTACT phone: 13566511755 email: nblejing@aliyun.com lat: 29.87819 lon: 121.54945 facility: Taizhou Hospital of Zhejiang status: RECRUITING city: Taizhou country: China name: Yiqun Guo role: CONTACT phone: 13515861286 email: guoqunyi@163.com lat: 32.49069 lon: 119.90812 hasResults: False
nctId: NCT06290804 id: drezgiyucel0000000193593877 briefTitle: Assessing Sustainable Behaviors and Health Impacts of Climate Change overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-15 date: 2024-03 date: 2024-07 date: 2024-03-04 date: 2024-03-04 name: Eskisehir Osmangazi University class: OTHER briefSummary: The relationship between climate change, sustainability and child health is complex and important. These three concepts are interacting factors and have significant impacts on children's health. Sustainability measures are vital to protect child health by mitigating the impacts of climate change. At the same time, children's education and awareness is an important factor that will contribute to future generations living in a sustainable world. As a society, tackling climate change and striving for a sustainable future is crucial to ensure that children live healthy and safe lives. The aim of this study is to evaluate the effectiveness of the education program and educational videos to be applied to children in terms of environmentally sustainable behaviors and awareness of the health effects of climate change in 60-72-month-old children studying in Eskişehir Odunpazarı Municipality Day Care Center and Nurseries. In addition, in this study, it was aimed to measure the level of global climate change awareness of parents and to evaluate the relationship with children's environmentally sustainable behaviors. conditions: Climate Change conditions: Child Health studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 38 type: ESTIMATED name: education measure: increasing sustainable behaviors measure: raising awareness of the health impacts of climate change measure: raising awareness of global climate change sex: ALL minimumAge: 60 Months maximumAge: 72 Months stdAges: CHILD facility: Ezgi Yücel city: Odunpazarı state: Eskişehir zip: 553 723 43 57 country: Turkey lat: 39.76821 lon: 30.53538 hasResults: False
nctId: NCT06290791 id: K2020214 briefTitle: Does a Drain Tube Influence the Postoperative Epidural Haematoma for Lumbar Biportal Endoscopic Surgery? overallStatus: COMPLETED date: 2020-12-31 date: 2023-12-31 date: 2024-02-10 date: 2024-03-04 date: 2024-03-04 name: The Fourth Affiliated Hospital of Zhejiang University School of Medicine class: OTHER briefSummary: The purpose of this study was to evaluate if wound drains could influence postoperative spinal epidural hematoma (POSEH) in biportal endoscopic spinal surgery (BESS) procedures for decompression of lumbar spinal stenosis. conditions: Drain Tube Influence the Postoperative Epidural Haematoma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 89 type: ACTUAL name: two level lumbar decompression with BESS procedure received one drain. name: two level lumbar decompression with BESS procedure received two drain. measure: the cross-sectional area of POSEH measure: the volume of drain output sex: ALL minimumAge: 20 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Zhonglin Zhong city: Yiwu state: Zhejiang zip: 322000 country: China lat: 29.31506 lon: 120.07676 hasResults: False
nctId: NCT06290778 id: Baylor IRB #023-445 briefTitle: Peer Delivered, Emotion Regulation-Focused Mental Health Prevention Training for Fire Fighter Trainees acronym: PEER UP overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2027-08 date: 2027-08 date: 2024-03-04 date: 2024-03-05 name: Baylor Research Institute class: OTHER name: University of Pittsburgh name: Boston University name: Texas A&M University briefSummary: The goal of this clinical trial is to determine if a peer-delivered emotion regulation training (Brief-Unified Protocol) workshop is effective for preventing posttraumatic stress and other psychological health symptoms in firefighter trainees. The main questions it aims to answer are:
Researchers will compare firefighters who receive a peer-delivered Brief-Unified Protocol workshop to firefighters who receive peer-delivered psychoeducation to see if the Brief-Unified Protocol is effective for preventing posttraumatic stress and other psychological health symptoms. conditions: PTSD conditions: Alcohol Use Disorder conditions: Depression conditions: Anxiety studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 480 type: ESTIMATED name: Brief Unified Protocol name: Psychoeducation measure: PTSD Symptoms measure: Alcohol Use Disorder symptoms measure: Depression symptoms measure: Anxiety symptoms measure: Functional Impairment sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06290765 id: A23-401 briefTitle: Efficacy and Safety of Ropeginterferon Alfa 2b (P1101) for Patients With Low-Risk Polycythemia Vera acronym: PV overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-12-31 date: 2027-02-28 date: 2024-03-04 date: 2024-03-04 name: PharmaEssentia class: INDUSTRY briefSummary: This is a randomized, open-label, multicenter, two-arm study to assess the efficacy and safety of ropeginterferon alfa-2b for patients with low-risk PV. Approximately 110 patients with low-risk PV will be enrolled. The whole study period is 108 weeks, including a main treatment phase (56 weeks), an extension treatment phase (48 weeks), and a safety follow-up phase (four weeks). conditions: Polycythemia Vera conditions: Myeloproliferative Neoplasm studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 110 type: ESTIMATED name: Ropeginterferon alfa-2b name: Phlebotomy measure: The proportion of patients with treatment response evaluated. Treatment response is defined as the maintenance of the median HCT values <45% over time, without progression of disease, and no need of any extra-protocol cytoreductive drugs. sex: ALL minimumAge: 18 Years maximumAge: 59 Years stdAges: ADULT hasResults: False
nctId: NCT06290752 id: KY-2024-030 briefTitle: Determining the Learning Curve for Ultrasound-guided Caudal Epidural Block overallStatus: RECRUITING date: 2024-03-01 date: 2024-11-30 date: 2024-12-31 date: 2024-03-04 date: 2024-03-12 name: The Fourth Affiliated Hospital of Zhejiang University School of Medicine class: OTHER briefSummary: mastering ultrasound-guided sacral canal block entails traversing a multifaceted learning curve characterized by anatomical intricacies, technical challenges, and patient variability. Through systematic education, deliberate practice, and clinical experience, clinicians can ascend this learning curve and harness the full potential of this innovative technique in pain management. As the landscape of regional anesthesia continues to evolve, a commitment to ongoing learning and proficiency attainment is paramount for delivering safe, effective, and patient-centered care. conditions: Anesthesia studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: PROSPECTIVE count: 6 type: ESTIMATED measure: operation time sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Dongmei Ma status: RECRUITING city: Yiwu state: Zhejiang zip: 322000 country: China name: Zhu Xinqiang role: CONTACT phone: +8657989935052 lat: 29.31506 lon: 120.07676 hasResults: False