nctId: NCT06350617 id: 2023-12-028 briefTitle: Personalized rTMS Protocol Based on Functional Reserve to Enhance Ambulatory Function in PD Patients overallStatus: RECRUITING date: 2024-02-20 date: 2025-09-30 date: 2025-09-30 date: 2024-04-05 date: 2024-04-05 name: Samsung Medical Center class: OTHER name: National Research Foundation of Korea name: Ministry of Food and Drug Safety, Korea name: Seoul National University Hospital name: Bucheon St. Mary's Hospital name: Saint Vincent's Hospital, Korea name: Severance Hospital name: Kumoh National Institute of Technology name: NEUROPHET briefSummary: The objective of this study was to determine the effects of protocols of repetitive transcranial magnetic stimulation (rTMS) therapy based on the functional reserve of each patient with Parkinson's disease, compared to conventional high-frequency rTMS therapy on bilateral primary motor cortex (M1). Investigators hypothesized that the functional reserve of each patient with Parkinson's disease will be different, and therefore an appropriate simulating target for rTMS therapy is needed. In addition, this approach could be more effective compared to conventional protocols applied to patient with Parkinson's disease regardless of their severity, predicted mechanism of motor function recovery, or functional reserves. conditions: Parkinson's Disease and Parkinsonism studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: prospective, single-blind with blind observer, parallel-group design, multi-center, randomized controlled clinical trial primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: The participants, assessors, and investigators will be blinded, not be aware of the group allocation. Statistical analysis will also be conducted by data analysts without awareness of the group allocation. Only clinicians applying rTMS intervention will not be blinded, as they will apply rTMS over different stimulation sites based on the protocols. Blinding will be continued until the end of the study, including data analysis. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: High-Frequency, ipsilateral M1 name: High-Frequency, bilateral M1 name: High-Frequency, Lt. DLPFC name: High-Frequency, bilateral M1 measure: Differences of Timed Up and Go Test (TUG) measure: Differences of Timed Up and Go Test (TUG) measure: Differences of Timed Up and Go Test (TUG) measure: Differences of Timed Up and Go Test-Cognitive (TUG-Cog) measure: Differences of Timed Up and Go Test-Cognitive (TUG-Cog) measure: Differences of Timed Up and Go Test-Cognitive (TUG-Cog) measure: Differences of Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Part III measure: Differences of MDS-UPDRS, Part III measure: Differences of New Freezing of Gait Questionnaire (FoG-Q) measure: Differences of New Freezing of Gait Questionnaire (FoG-Q) measure: Differences of Digit span Test measure: Differences of Digit span Test measure: Differences of Trail making Test measure: Differences of Trail making Test measure: Differences of Gait lab parameter (Gait speed) measure: Differences of Gait lab parameter (Gait speed) measure: Differences of Gait lab parameter (Stride length) measure: Differences of Gait lab parameter (Stride length) measure: Differences of Gait lab parameter (Step count) measure: Differences of Gait lab parameter (Step count) measure: Differences of Gait lab parameter (Cadence) measure: Differences of Gait lab parameter (Cadence) measure: Differences of Gait lab parameter (Swing ratio) measure: Differences of Gait lab parameter (Swing ratio) measure: Differences of Gait lab parameter (Stride time) measure: Differences of Gait lab parameter (Stride time) measure: Differences of Gait lab parameter (Pressure distribution) measure: Differences of Gait lab parameter (Pressure distribution) sex: ALL minimumAge: 50 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Samsung Medical Center status: RECRUITING city: Seoul zip: 06351 country: Korea, Republic of name: Won Hyuk Chang, PhD role: CONTACT phone: +82-2-3410-6068 email: wh.chang@samsung.com lat: 37.566 lon: 126.9784 hasResults: False