hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06348823 id: BritishUE briefTitle: Relationship Between Soft Tissue Volume and Gingival Phenotype: A Novel Classification System overallStatus: RECRUITING date: 2024-02-25 date: 2024-06 date: 2024-10 date: 2024-04-05 date: 2024-04-09 name: Ain Shams University class: OTHER name: British University In Egypt briefSummary: Different classifications to describe alveolar ridge defects have been published over the past years but no single classification has been developed concerning soft tissue volume around teeth or dental implants. Moreover, while several studies investigated the effect of various augmentation techniques and materials on soft tissue volume change and volume stability there is a real gap of knowledge regarding how to evaluate the available soft tissue volume and when to consider it sufficient or deficient which would definitely improve clinical decision making and treatment planing. Therefore, our primary aim was to assess the application of a novel classification system based on the correlation between buccal soft tissue volume and gingival biotypes and, also to assess the sensitivity of such novel method. conditions: Gingival Biotype conditions: Soft Tissue studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: CROSS_SECTIONAL count: 56 type: ESTIMATED name: volume survey measure: soft tissue volume - biotype correlation sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ahmed Hamdy status: RECRUITING city: Cairo zip: 11234 country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06348810 id: DTT2024 briefTitle: Dual-Task Training for People With Mild Cognitive Impairment and Mild Dementia acronym: DTT overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-01-15 date: 2025-01-15 date: 2024-04-05 date: 2024-04-05 name: Taipei Medical University class: OTHER briefSummary: Evidence shows that people with dementia have a higher prevalence of sleep disturbance, cognitive decline, behavioral disturbance, and experience motor dysfunction. These symptoms are interrelated. However, few randomized controlled trial (RCT) studies implement dual-task training for mild cognitive impairment and mild dementia, especially for those who experience sleep problems and behavioral disturbances.
The length of dual-task training is 6 weeks; sessions are 3 times per week, each session lasts 45 minutes, and total sessions are 18. While the control group receives the usual care. Researchers will compare the experiment and control groups to see the effect of the dual-task training. conditions: Dementia conditions: Mild Cognitive Impairment conditions: Older Adult studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: eksperimental group receive dual-task training, while control group receive usual care and both conduct at the same time primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: Outcomes Assessor will be blind, so they didnt know which is intervention group or control group whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Dual-task training name: Usual care measure: Global cognitive function measure: Executive function measure: Working memory measure: Sleep Quality measure: Behavioral disturbance measure: Balance measure: Flexibility sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Nursing Home city: Malang state: Jawa Timur zip: 65216 country: Indonesia name: Nur Aini, MSc role: CONTACT phone: +6285234727354 email: d432110003@tmu.edu.tw lat: -7.9797 lon: 112.6304 hasResults: False
nctId: NCT06348797 id: BHP01-01 briefTitle: Phase I Clinical Study of α-PD-L1/DLL3 CAR-T in Patients With R/R SCLC overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-07-31 date: 2026-12-31 date: 2024-04-05 date: 2024-04-05 name: Sichuan University class: OTHER name: Chengdu Brilliant Pharmaceutical Co., Ltd. briefSummary: A study to evaluate the safety and feasibility of α-PD-L1/4-1BB DLL3 Chimeric Antigen Receptor (CAR)-T (BHP01) in patients with Relapsed/Refractory Small Cell Lung Cancer (SCLC) and determine the appropriate CAR-T cell dose. Next, In dose expansion phase, patients were assign two groups with/without bridge radiotherapy. conditions: Small Cell Lung Cancer Extensive Stage studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 28 type: ESTIMATED name: α-PD-L1/4-1BB DLL3 CAR-T (BHP01) measure: Dose-limiting toxicity (DLT) measure: Objective Response Rate (ORR) measure: Progression-free survival (PFS) measure: Disease control rate (DCR) measure: Duration of response (DOR) measure: Overall-Survival (OS) measure: CAR-T cell numbers sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06348784 id: 11 briefTitle: Screening for Ovarian Malignancy overallStatus: COMPLETED date: 2022-01-01 date: 2023-01-01 date: 2023-01-01 date: 2024-04-05 date: 2024-04-05 name: Ain Shams Maternity Hospital class: OTHER briefSummary: Ovarian cancer is the second most common gynecologic malignancy. In 2008, it was the seventh leading cause of cancer deaths in women worldwide. Estimating the risk of malignancy is essential in the management of adnexal masses and several mathematical models and scoring systems have been developed to be used for discrimination between benign and malignant adnexal masses. Knowledge of the specific type of adnexal pathology before surgery is likely to improve patient triage with high accuracy, and it also makes it possible to optimize treatment. The correct identification of stage I cancer is particularly important conditions: Early Detection of Ovarian Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ACTUAL name: Assesment of Different NEoplasias in the adenexa model name: Risk of malignancy index name: Histopathologic examination measure: Sensitivity, specificity, positive predictive, and negative predictive value of Assessment of Different NEoplasias in the adneXa model for differentiating between benign and malignant ovarian tumors sex: FEMALE minimumAge: 40 Years stdAges: ADULT stdAges: OLDER_ADULT facility: AinShams university maternity hospital city: Cairo country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06348771 id: Pro2023001579 briefTitle: Postprandial Inflammation and Nuts (PIN) in Older Adults acronym: PIN overallStatus: RECRUITING date: 2024-03-25 date: 2024-10-30 date: 2025-01-30 date: 2024-04-05 date: 2024-04-05 name: Rutgers, The State University of New Jersey class: OTHER briefSummary: The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice, but are not consumed frequently enough in older adults. Studies have shown that regular nut consumption is associated with lower adiposity and reduced weight gain and inflammation. Given these findings, this study will examine the postprandial effects of meals with 2 levels of saturated fatty acids (SFA) on metabolic endotoxemia, inflammation and satiety, using a randomized cross-over design. The low SFA meal includes peanuts that are high in monounsaturated fatty acids (MUFA) and this will be compared to a high SFA meal. The results of this study have the potential to provide valuable insights into the role of peanuts in promoting health and preventing disease in at-risk older adults. conditions: Healthy Aging conditions: Overweight and Obesity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Higher SFA meal vs higher MUFA (nut) meal in individuals with overweight and obese primaryPurpose: PREVENTION masking: NONE count: 18 type: ESTIMATED name: monounsaturated fatty acids (MUFA) peanut meal measure: Concentration of Endotoxin measure: Concentration of Interleukin-6 measure: Concentration of Glucose and Insulin measure: Concentration of Triglyceride measure: Appetite measure: Concentration of Inflammatory markers measure: Concentration of zonulin measure: Lipid Profile measure: Characterization of the Microbiome measure: Concentration of incretin hormones measure: Concentration of Bone regulating markers sex: ALL minimumAge: 55 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Foran Hall status: RECRUITING city: New Brunswick state: New Jersey zip: 08901 country: United States name: Sue Shapses, PhD role: CONTACT phone: 848-932-9403 email: shapses@rutgers.edu name: Rebecca Serrano, RD MPH role: CONTACT phone: 848-932-9403 email: rcjs@cinj.rutgers.edu lat: 40.48622 lon: -74.45182 facility: Rutgers University - NJ Inst Food Nutrition & Health status: RECRUITING city: New Brunswick state: New Jersey zip: 08901 country: United States name: Sue A Shapses role: CONTACT phone: 848-932-9403 email: shapses@rutgers.edu lat: 40.48622 lon: -74.45182 hasResults: False
nctId: NCT06348758 id: KAP towards AI briefTitle: Knowledge, Attitudes, And Perceptions of a Group of Egyptian Dental Students Towards Artificial Intelligence acronym: AIKnowledge overallStatus: ENROLLING_BY_INVITATION date: 2024-02-11 date: 2024-06-07 date: 2024-08-07 date: 2024-04-05 date: 2024-04-05 name: Cairo University class: OTHER briefSummary: In the context of this ongoing AI revolution, it is essential to ensure that current and future clinical practitioners are up to date regarding this technology's current state and potential. It is valuable to assess the current attitude of clinical dentists and undergraduate students in dentistry regarding the future role of AI.
To the best of the author's knowledge, there is no study about Egyptian dental students' views and attitudes regarding the application of AI in dental practice. Therefore, this study aimed to evaluate the attitudes and perceptions of a group of dental students in Egypt towards AI. conditions: Health Knowledge, Attitudes, Practice studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: CROSS_SECTIONAL count: 384 type: ESTIMATED name: questionnaire measure: knowledge, attitudes, and perceptions about artificial intelligence in Dentistry sex: ALL minimumAge: 18 Years maximumAge: 25 Years stdAges: ADULT facility: Cairo University- Faculty of Dentistry city: Cairo country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06348745 id: diaphragmatic ultrasound briefTitle: Trans Thoracic Ultrasound to Assess Diaphragmatic Function in Stable COPD Versus Bronchial Asthma. overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-05-01 date: 2024-04-05 date: 2024-04-08 name: Assiut University class: OTHER briefSummary: * Assessment of diaphragmatic function (excursion, thickness variation, thickness ratio) in COPD and bronchial asthma patients.
* Assessment of possible association between diaphragmatic dysfunction and presence of reversibility in pulmonary function post bronchodilator. conditions: Diaphragm studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: SINGLE whoMasked: PARTICIPANT count: 80 type: ESTIMATED name: ultrasound measure: diaphragmatic function measure: pulmonary function . sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06348732 id: biomarkers in cardiomyopathy briefTitle: Diagnostic and Prognostic Role of Troponin and Brain Natriuretic Peptide in Pediatric Patients With Cardiomyopathy in Correlation to Echocardiography Findings overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2025-09 date: 2025-11 date: 2024-04-05 date: 2024-04-05 name: Assiut University class: OTHER briefSummary: This study aims to assess the the role of cardiac biomarkers (troponin and ProBNP) in pediatric Patients with all types of cardiomyopathy in correlation with echocardiography findings . conditions: Cardiomyopathies studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 65 type: ESTIMATED measure: Diagnostic and Prognostic Role of Troponin and Pro BNP in Pediatric Patients with Cardiomyopathy in correlation to Echocardiography findings . sex: ALL minimumAge: 1 Month maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06348719 id: 35RC21_9732_ROBOT-ECO-GYN briefTitle: Medico-economic Evaluation of Robot-assisted Laparoscopy Compared With Conventional Laparoscopy in Hysterectomy for Endometrial Cancer. acronym: ROBOT-ECO-GYN overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-10 date: 2027-10 date: 2024-04-05 date: 2024-04-05 name: Rennes University Hospital class: OTHER briefSummary: The standard treatment for endometrial cancer is surgery, as long as the stage of the disease and the patient's condition allow. It consists of hysterectomy (TSH) with bilateral adnexectomy. The recommended surgical approach is the minimally invasive or laparoscopic route, whose oncological safety has been demonstrated by the LAP2 study.
The investigators therefore hypothesise that robot-assisted laparoscopy could be more efficient than conventional laparoscopy for endometrial cancer hysterectomy in the context of an advanced learning curve in France. The investigators will also test the efficiency of the surgical technique as a function of age and Body mass Index. conditions: Hysterectomies for Low- or Intermediate-risk Endometrial Carcinoma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: As part of this project, we are proposing an original approach by combining a randomized controlled trial with a prospective observational cohort and a retrospective cohort.
nctId: NCT06348706 id: Ain Shams University25032024 briefTitle: Effect of Dipeptidyl Peptidase- 4 Inhibitors on Non-Alcoholic Steatohepatitis and Type 1 Diabetes overallStatus: COMPLETED date: 2022-11-10 date: 2023-12-01 date: 2024-01-15 date: 2024-04-05 date: 2024-04-05 name: Ain Shams University class: OTHER briefSummary: Background: Non-alcoholic steatohepatitis (NASH) is an advanced form of non-alcoholic fatty liver disease (NAFLD) that can precipitate to advanced fibrosis and leads to cardiovascular morbidity and mortality. Many patients with type 1 diabetes mellitus (T1DM) had histological evidence of steatosis and met the histological criteria for NASH. Matrix metalloproteinase-14 (MMP-14) is a type 1 transmembrane proteinase expressed in liver fibrosis and is involved in the development of atherosclerosis and cardiovascular disease. Hepatic dipeptidyl peptidase-4 (DPP-4) expression in NAFLD may be directly associated with hepatic lipogenesis and liver injury. Some studies showed the beneficial effect of dipeptidyl peptidase-4 (DDP-4) inhibitors in NAFLD/NASH for their role in improving hepatic glucose metabolism. Vildagliptin, a DPP-4 inhibitor, could be promising therapeutic agents for NAFLD/NASH.
Methods: This study included 60 adolescents with T1DM and NASH with a mean age 15.6 ± 2.08 years and disease duration ≥ 5 years. Forty age- and sex-matched healthy subjects with a mean age 14.9 ± 3.2 years were enrolled as healthy controls to compare MMP-14 levels. T1DM patients were randomly assigned to receive oral vildagliptin (50 mg daily) with lunch meal for six months or not. Fasting and 2 hours post-prandial blood glucose levels, HbA1c, liver function tests, fasting lipid profile, hepatic steatosis index and triglyceride glucose (TyG) index were assessed. MMP-14 levels were measured by enzyme-linked immunosorbent assay among all patients and healthy controls. CIMT was assessed using Doppler ultrasound and transient elastography with controlled attenuation parameter (CAP) was performed to assess liver stiffness and steatosis stage. conditions: Diabetes Mellitus, Type 1 conditions: NASH studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ACTUAL name: Dipeptidyl peptidase 4 (DPP-4) inhibitor measure: Number of participants with treatment-related effect on NASH status in adolescents with type 1 diabetes mellitus measure: Number of participants with treatment-related Matrix metalloproteinase-14 (MMP-14) level change measure: Number of participants with treatment-related Glycemic control (HbA1c%) level change sex: ALL minimumAge: 12 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Nancy Elbarbary city: Cairo zip: 11361 country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06348693 id: Gliotherapy briefTitle: Development of Therapeutic Approaches Modulating Molecular Targets Implicated on Cancer Stem Cell-related Aggressiveness overallStatus: RECRUITING date: 2017-04-19 date: 2025-11-21 date: 2025-11-21 date: 2024-04-05 date: 2024-04-05 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico class: OTHER briefSummary: Tumors of the central nervous system affect 21 people per 100,000 every year, a figure that refers to countries with advanced economies, with an increase in incidence over time. Experimental evidence suggests that cancer stem cells (CSCs) may play a key role in the malignancy of these tumors. In fact, due to the hypoxic tumor microenvironment, these cells are able to create compensatory pathways that confer stem-like, angiogenic and pro-tumoral functions. Furthermore, it has been demonstrated that brain tumor stem cells are radio- and chemo-resistant and therefore not treatable with the therapeutic protocols currently in use. To date, in fact, there are no definitive treatments for the eradication of brain tumors. In this scenario, sphingolips, a class of lipid deputized to several physiological functions, are also involved in tumor onset, progression, drug resistance, and aggressiveness. In hypoxic tumor microenvironment, CSCs present a modified rheostat in the metabolism of sphingolipid, in favor of Sphingosine-1-phosphate (S1P).
The project aims to identify new molecular and metabolic targets involved in the survival and chemo-resistance of tumor stem cells in relation to the tumor microenvironment. conditions: Glioblastoma conditions: Glioma conditions: Glioma Glioblastoma Multiforme studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 400 type: ESTIMATED name: cell isolation from tumor biopsies and biomarker investigation measure: Investigation of molecular and metabolic signature of cancer stem cells to assess specific markers related to gliomagenesis and cancerogenesis. measure: Biomarker investigation measure: Cellular response to pharmacological treatments sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico status: RECRUITING city: Milan zip: 20122 country: Italy name: Stefania E Navone, PhD role: CONTACT phone: 0255034268 phoneExt: +39 email: stefania.navone@policlinico.mi.it name: Giovanni Marfia, MD, PhD role: CONTACT phone: 0255034268 phoneExt: +39 email: giovanni.marfia@policlinico.mi.it name: Stefania Navone, PhD role: PRINCIPAL_INVESTIGATOR name: Giovanni Marfia, MD, PhD role: SUB_INVESTIGATOR name: Laura Guarnaccia, PhD role: SUB_INVESTIGATOR name: Laura Begani, MSc role: SUB_INVESTIGATOR name: Marco Locatelli, Md, PhD role: SUB_INVESTIGATOR name: Claudia Fanizzi, MD role: SUB_INVESTIGATOR name: Luigi Schisano, MD role: SUB_INVESTIGATOR name: Antonella Ampollini, MD role: SUB_INVESTIGATOR name: Manuela Caroli, MD role: SUB_INVESTIGATOR name: Giulio Bertani, MD role: SUB_INVESTIGATOR name: Giorgio Fiore, MD role: SUB_INVESTIGATOR name: Antonio D Ammando, MD role: SUB_INVESTIGATOR name: Elena Scagliotti, MSc role: SUB_INVESTIGATOR name: Giorgia Abete Fornara, MSc role: SUB_INVESTIGATOR lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06348680 id: AmasyaU-betuluzun-004 briefTitle: The Effect of Video-assisted Episiotomy Repair Training on Anxiety and Self-efficacy Levels in Midwifery Students overallStatus: NOT_YET_RECRUITING date: 2024-03-25 date: 2024-04-05 date: 2024-05-15 date: 2024-04-05 date: 2024-04-05 name: Amasya University class: OTHER briefSummary: The goal of midwifery undergraduate education is; To provide students with basic professional knowledge, skills and attitudes in cognitive, affective and psychomotor dimensions. Various practices are used to provide students with midwifery skills. Case studies, maintenance processes, laboratory applications, field studies, simulation application and video monitoring are some of these applications. Each of these approaches, which are especially preferred in applied courses, has an important place in increasing students' self-efficacy and reducing their anxiety. Episiotomy is one of the obstetric interventions that negatively affects the self-efficacy of midwifery students and causes anxiety. Midwives are responsible for performing and caring for episiotomy. In many countries, episiotomy repair training is given to midwifery students using sponges or models. However, today the use of calf tongue, which is very similar to perineal tissue, has become widespread. There are a limited number of studies in the literature using calf tongue simulation. These studies suggested that the practice improved the skills of midwifery students. No study has been found in the literature using video-assisted episiotomy repair training. conditions: Episiotomy Wound studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE whoMasked: PARTICIPANT count: 31 type: ESTIMATED name: Video assisted episiotomy repair training measure: State Anxiety Scale measure: Episiotomy Skills Self-Efficacy Scale sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT hasResults: False
nctId: NCT06348667 id: 3184794 briefTitle: Effects of a Short- and Long-term 'Blackboard' Intervention on Ankle Stability in Older Adults overallStatus: RECRUITING date: 2024-03-07 date: 2024-06-10 date: 2024-06-10 date: 2024-04-05 date: 2024-04-05 name: University of Valencia class: OTHER briefSummary: The goal of this clinical trial is to assess the effectiveness of adding specific Blackboard Training (BB) exercises to conventional physiotherapy in improving foot and ankle parameters essential for fall prevention among older adults.
Researchers will compare the intervention group's outcomes with those of the control group to determine the effectiveness of adding BB exercises in improving foot and ankle parameters related to fall prevention. conditions: Fall studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 32 type: ESTIMATED name: Specific ankle stability exercises name: Conventional physiotherapy exercises program measure: Foot and ankle pain measure: Foot and ankle strength measure: Foot and ankle ROM measure: Ankle dorsiflexion under load measure: Center of pressures variations (anteroposterior and mediolateral center of pressure displacement, velocity, and total surface) measure: Monopodal stability measure: Functional stability sex: ALL minimumAge: 75 Years maximumAge: 95 Years stdAges: OLDER_ADULT facility: Rodrigo Martin-San Agustin status: RECRUITING city: Valencia country: Spain name: Rodrigo Martin-San Agustin role: CONTACT phone: +34 963 983 853 email: rodrigo.martin@uv.es lat: 39.46975 lon: -0.37739 hasResults: False
nctId: NCT06348654 id: 6392 briefTitle: New Digital Person-based Care Model in Patients With HER2-negative Advanced Breast Cancer acronym: InPERSON overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2024-12-01 date: 2025-01-01 date: 2024-04-05 date: 2024-04-05 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: The goal of the InPerson study is to employ all resources in a digital listening platform to benefit the quality of life of patients (QoL) with advanced HER2-negative breast cancer.