hackint0sh/New-Dataset huggingface dataset:
3. Derive polygenic risk scores on post-transplant blood and/or kidney biopsy samples which predict kidney allograft dysfunction conditions: Transplant Complication conditions: Kidney Transplant Rejection studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: Biomarker discovery and validation - with focus on genomic biomarkers measure: Death censored graft loss (DCGL) measure: Biopsy proven rejection (BPAR) measure: All cause graft loss measure: Death measure: Treatment resistant rejection measure: Hospital admission or emergency attendance measure: Delayed Graft Function (DGF) measure: Kidney function measure: Albuminuria measure: Surrogate end-point markers measure: Borderline rejeciton measure: chronic rejection; chronic transplant glomerulopathy; and interstitial fibrosis and tubular atrophy (IFTA) scores measure: Recurrent disease measure: BK virus complications measure: Major cardiovascular complications measure: Major infectious complications measure: Malignancy post transplantation measure: Kidney biopsy transcriptomic signature measure: Kidney cell type composition measure: Proteinomic signature sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06365398 id: SELECT id: XWHL-2018010 type: OTHER_GRANT domain: Xuanwu Hospital, Capital Medical University briefTitle: Safety and Efficacy of Low-dose hEparinization in Cerebral Angiography sTudy acronym: SELECT overallStatus: COMPLETED date: 2018-01-01 date: 2021-06-01 date: 2022-01-01 date: 2024-04-15 date: 2024-04-15 name: Xuanwu Hospital, Beijing class: OTHER briefSummary: Purpose: Systemic heparinization is a widely used technique on digital subtraction angiography (DSA). Heparin, however, is associated with a variety of complications, including hemorrhage, thrombocytopenia, and hematomas. This study aimed to investigate the safety and efficacy of micro-dose systemic heparinization or no heparinization on cerebral angiography for cerebrovascular diseases.
Methods: A prospective, single-blind, randomized controlled study on patients who experienced transient ischemic attacks (TIAs) or acute ischemic strokes and underwent DSA is performed. Participants are randomized into three groups: regular-dose systemic heparinization, micro-dose systemic heparinization, and no heparinization. Information on patient demographics, laboratory tests, perioperative complications, and back pain scores is collected. Safety endpoints are defined as cerebral ischemic events and local complications of puncture site. Efficacy endpoints were defined as the recovery of the patients. conditions: Cerebral Angiography conditions: Heparinization studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: All patients enrolled are randomly divided into three groups according to the random number principle, which includes conventional systemic heparinization group, micro-dose systemic heparinization, and heparin-free angiography. It is carried out with a 1:1:1 ratio and variable block sizes. primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 180 type: ACTUAL name: Heparin name: Heparin Sodium Injection name: No heparinization measure: postoperative cerebral infarction measure: Numerical Rating Scale (NRS) for back pain measure: the incidence of paralysis of surgical limb measure: the incidence of pain of surgical limb measure: the incidence of postoperative urethral catheterization sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Xuanwu Hospital, Capital Medical University city: Beijing state: Beijing country: China lat: 39.9075 lon: 116.39723 facility: Xuanwu Hospital, Capital Medical University. city: Beijing zip: 100053 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06365385 id: FOODSEQ-MARS briefTitle: Postprandial Metabolic and Appetite Responses to Different Food Intake Sequences in Athletes overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-09 date: 2024-10 date: 2024-04-15 date: 2024-04-15 name: Universidade do Porto class: OTHER name: Federação Portuguesa de Futebol name: Fundação para a Ciência e a Tecnologia briefSummary: Emerging evidence suggests that following a 'carbohydrate-last meal pattern', wherein foods rich in protein, fat, fiber, and/or polyphenols are consumed before sources of simple carbohydrate (CHO) in a meal, results in reduced postprandial glycaemic responses than the reverse food order or a co-ingestion pattern. This effect has been observed across the spectrum of glucose tolerance, from patients with diabetes to individuals with normal glucose tolerance (Kuwata et al., 2016; Nishino et al., 2018; Lu et al., 2019; Sun et al., 2020). Furthermore, reduced glucose excursions have been linked to decreased subsequent hunger and energy intake (Lu et al., 2019; Wyatt et al., 2021).
However, to date, no studies on food intake sequence have targeted athletes, despite their increased CHO demands (Thomas et al., 2016) which could expose them to repeated episodes of hyperglycaemia and high glycaemic variability, known to increase the risk of adverse cardiovascular outcomes and all-cause mortality (Loader et al., 2015; Cavero-Redondo et al., 2017; Faerch et al., 2018). Additionally, athletes often face pressure to meet body composition standards and may benefit from strategies that enhance satiety and craving control. Finally, there is reason to believe that better glycaemic control could lead to improved performance, given that enhancements in endurance activities have been observed with a low-glycemic-index diet compared to a high-glycemic-index diet (Heung-Sang Wong et al., 2017).
Therefore, this randomised crossover trial is part of a wider project which seeks to explore the impact of food intake sequence on metabolic health and performance in athletes. Specifically, this trial aims to investigate the acute, postprandial metabolic and appetite responses to consuming an identical meal in two intake sequences (CHO-last versus CHO-first) in athletes, while in the resting state. conditions: Healthy conditions: Nutrition, Healthy conditions: Postprandial Hyperglycemia conditions: Hunger conditions: Craving studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: This study is a randomised controlled trial with a counterbalanced crossover design. Block randomisation will be performed by an external researcher, and allocation concealment will be ensured through the use of sequentially numbered, opaque, sealed envelopes. primaryPurpose: BASIC_SCIENCE masking: SINGLE maskingDescription: This is a non-blind trial, since both participants and the investigator delivering the test-meal will be able to see the ingredients and the order in which they are consumed. However, outcome assessors will be blinded to the intervention sequence. whoMasked: OUTCOMES_ASSESSOR count: 15 type: ESTIMATED name: Carbohydrate-last meal pattern name: Carbohydrate-first meal pattern measure: Postprandial blood glucose concentrations measure: Postprandial subjective appetite ratings measure: Prospective ad libitum energy intake measure: Prospective ad libitum nutritional intake measure: Postprandial serum insulin concentrations measure: Postprandial plasma total GLP-1 concentrations measure: Postprandial plasma total GIP concentrations measure: Postprandial serum total ghrelin concentrations measure: Postprandial plasma total PYY concentrations measure: Postprandial serum triglyceride concentrations measure: Postprandial serum NEFA concentrations sex: MALE minimumAge: 18 Years maximumAge: 64 Years stdAges: ADULT hasResults: False
nctId: NCT06365372 id: MrgD and PAH briefTitle: Circulating MrgD in Pulmonary Hypertension overallStatus: RECRUITING date: 2024-04-10 date: 2024-05-10 date: 2024-06-01 date: 2024-04-15 date: 2024-04-15 name: Qilu Hospital of Shandong University class: OTHER briefSummary: The aim of the study is to observe the change of the circulating MrgD level in patients with pulmonary hypertension compared with subjects without pulmonary hypertension. conditions: Pulmonary Hypertension studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 90 type: ESTIMATED name: Western blot measure: Circulating MrgD level sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Qilu Hospital of Shandong University status: RECRUITING city: Jinan state: Shandong zip: 250012 country: China name: Panpan Hao, MD, PHD role: CONTACT email: panda.how@126.com name: Hongyu Zhong, MD role: SUB_INVESTIGATOR lat: 36.66833 lon: 116.99722 hasResults: False
nctId: NCT06365359 id: 23_RIPH2-12 briefTitle: Systemic Lupus Erythematosus and Chlordecone Impregnation in Martinique acronym: LUNEK overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-10-15 date: 2025-11-15 date: 2024-04-15 date: 2024-04-15 name: University Hospital Center of Martinique class: OTHER name: Institut Pasteur de Guadeloupe name: Centre de Ressources Biologiques de la Martinique (CeRBiM) briefSummary: Chlordecone, an organochlorine pesticide, was widely used on banana farms in the French West Indies. Studies by Inserm and health authorities have confirmed the contamination of the food chain and the majority of the population of the French West Indies by chlordecone.
Epidemiological studies conducted in the French West Indies have shown that exposure to chlordecone at the levels observed is associated with an increased risk of developing several diseases, including premature birth and prostate cancer. Many of the adverse effects associated with chlordecone could be explained by its estrogenic hormonal properties, and systemic lupus erythematosus (SLE) is an autoimmune disease whose sensitivity to estrogen is well known and is reflected by 1) its clear predominance in women, 2) its predominance in women of childbearing age, 3) its risk of exacerbation in the event of pregnancy.
Chlordecone also has a cellular effect that reduces the apoptosis of potentially auto-reactive lymphocytes and stimulates the production of GM-CSF, IL-2, TNF-alpha, and IFN-gamma. The latter is central to the pathophysiology of SLE. While experimental studies suggest a potential impact of chlordecone on SLE, no human studies have been conducted to date, and the chlordecone impregnation of lupus patients in Martinique remains unknown.
The most serious and feared complication of SLE is kidney damage. Kidney damage from the disease and the necessary immunosuppressive treatments can lead to significant morbidity and mortality, including death and end-stage chronic renal failure. Therefore, it is important to manage the disease carefully. Suspected lupus nephritis is confirmed by a renal biopsy, which allows for formal diagnosis and categorization into several classes. Suspected cases are identified by a proteinuria to creatininuria ratio greater than 0.5 g/g (or 24-hour proteinuria greater than 0.5g).
The objective of this project is to determine whether there is a positive association between lupus nephritis occurrence in patients followed by the internal medicine department of the Martinique University Hospital and organochlorine pesticide chlordecone impregnation. conditions: Systemic Lupus Erythematosus conditions: Renal Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED name: Blood sample for analysis of plasma of organochlorine pesticides concentration name: Blood sample for cell collection measure: To estimate the risk of presenting a renal complication of lupus disease based on the level of impregnation with chlordecone in the lupus patients seen at the Martinique University Hospital. measure: To compare the activity of lupus according to the level of impregnation with chlordecone. measure: To compare the after-effects of lupus according to the level of impregnation with chlordecone. measure: To describe the distribution of the plasma concentration of chlordecone in lupus patients followed by the internal medicine department of the Martinique University Hospital. measure: To describe the distribution of the plasma concentration of p,p'-DDE in lupus patients followed by the internal medicine department of the Martinique University Hospital. measure: To describe the distribution of the plasma concentration of βHCH in lupus patients followed by the internal medicine department of the Martinique University Hospital. measure: To describe the distribution of the plasma concentration of γHCH in lupus patients followed by the internal medicine department of the Martinique University Hospital. measure: To describe the distribution of the plasma concentration of PCB 153 in lupus patients followed by the internal medicine department of the Martinique University Hospital. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Center of Martinique city: Fort-de-France zip: 97261 country: France hasResults: False
nctId: NCT06365346 id: 2024.075-T briefTitle: Music Breathing Therapy for Children With Attention-deficit Hyperactivity Disorder and Their Caregivers overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-05-31 date: 2025-08-31 date: 2024-04-15 date: 2024-04-15 name: Chinese University of Hong Kong class: OTHER briefSummary: This pilot randomized controlled trial aims to evaluate the feasibility (in terms of rates of recruitment, retention, and attendance), acceptability, and potential effects of the dyadic video-assisted gamified music breathing therapy on dyads' resilience, children's emotional and behavioral symptoms, parents' parenting stress, and psychological distress. conditions: Resilience studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 48 type: ESTIMATED name: Dyadic video-assisted gamified group-based music breathing therapy name: Online educational modules measure: Resilience levels of children measure: Resilience levels of parents measure: Children's emotional and behavioral symptoms measure: Parenting stress measure: Parents' psychological distress (i.e., depression, anxiety and stress) measure: Feasibility outcomes - recruitment rate measure: Feasibility outcomes - retention rate measure: Feasibility outcomes - attendance measure: Acceptability of the intervention - level of satisfaction measure: Acceptability of the intervention sex: ALL minimumAge: 7 Years maximumAge: 12 Years stdAges: CHILD facility: The Chinese University of Hong Kong city: Hong Kong country: Hong Kong name: Ankie Tan Cheung, PhD role: CONTACT phone: 852 39430515 email: ankiecheung@cuhk.edu.hk lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06365333 id: 1451_04/BVNTW-VNCSKTE briefTitle: Pneumatic Reduction For Intussusception In Children: A Retrospective Cohort Study overallStatus: COMPLETED date: 2016-01 date: 2017-12 date: 2024-04 date: 2024-04-15 date: 2024-04-15 name: National Children's Hospital, Vietnam class: OTHER name: Vinmec Research Institute of Stem Cell and Gene Technology briefSummary: In pediatric patients, intussusception predominantly occurs in the ileocecal region, with over 90% of cases lacking identifiable causative factors, initiating through peristalsis-driven invagination of bowel segments leading to compromised blood flow and subsequent bowel edema. Persistent obstruction may progress to bowel ischemia and infarction. Vietnam exhibits a higher incidence of intussusception compared to other countries, albeit with similar clinical presentations and anatomical locations, hinting at shared pathophysiology. Despite evidence supporting the safety and efficacy of non-surgical reduction techniques, many medical centers in low- to middle-income countries (LMICs) have not adopted these methods, resulting in unnecessary surgical interventions. The Vietnam National Hospital of Pediatrics (NCH) has employed air enema reduction since the early 2000s but lacks a comprehensive study on fluoroscopic-guided air-enema reduction (FGAR) techniques or success rates. Thus, this study aims to evaluate the long-term outcomes of pneumatic reduction for intussusception at NCH, a high-volume institution in a lower-middle-income country. conditions: Intussusception studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 3562 type: ACTUAL name: Fluoroscopic-guided air-enema reduction (FGAR) measure: Complicated intussusception measure: ICU admission measure: Death measure: Failed FGAR measure: Recurrence sex: ALL minimumAge: 2 Months maximumAge: 30 Months stdAges: CHILD facility: The National Hospital of Pediatrics city: Hanoi country: Vietnam lat: 21.0245 lon: 105.84117 facility: Vinmec Research Institute of Stem Cell and Gene Technology city: Hanoi country: Vietnam lat: 21.0245 lon: 105.84117 hasResults: False
nctId: NCT06365320 id: PROTEOMET briefTitle: Association Between Training Load and Lactate and Other Metabolites Analyzed by Metabolomic and Proteomic Techniques acronym: PROTEOMET overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-07 date: 2024-07 date: 2024-04-15 date: 2024-04-15 name: Fundació Eurecat class: OTHER name: University Rovira i Virgili briefSummary: Physical exercise induces numerous changes in the body in a complex signalling network caused by or in response to increased metabolic activity of contracting skeletal muscles.
Microsampling systems emerge as an alternative to venipuncture by facilitating self-sampling, which can be carried out outside healthcare centres, in a comfortable and precise way from a small finger prick that the user can perform. These systems are less expensive and can be effective in measuring the levels of glucose metabolism products, such as lactate, through the application of metabolomics and proteomics. On the other hand, the use of non-invasive methods of measuring lactate levels is becoming increasingly popular in sports medicine. The use of saliva as an alternative fluid to the blood shows promise for identifying the concentrations of metabolites that occur during and after sports training. conditions: Lactate conditions: Sports Performance conditions: Metabolomics conditions: Proteomics studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single-group pretest-posttest design (quasi- experimental) primaryPurpose: OTHER masking: NONE maskingDescription: Given the nature of the study (pretest-posttest design), masking will not be possible. count: 70 type: ESTIMATED name: Single basketball training measure: Correlation between blood lactate levels and the subjective sensation of perceived effort measure: Change in saliva lactate levels measure: Change in blood lactate levels measure: Change in levels of lipid metabolic markers determined in capillary blood samples measure: Change in levels of other lipid metabolic markers determined in capillary blood samples measure: Change in levels of polar metabolites determined in capillary blood samples measure: Change in levels of lipid metabolic markers determined in saliva samples measure: Change in levels of other lipid metabolic markers determined in saliva samples measure: Change in levels of polar metabolites determined in saliva samples measure: Change in levels of proteomic markers determined in capillary blood samples measure: Change in levels of proteomic markers determined in saliva samples measure: Pittsburgh Sleep Quality Index measure: Heart rate variations measure: Sociodemographic data: age and birth date measure: Sociodemographic data: sex measure: Lifestyle data: weekly training load measure: Lifestyle data: playing position measure: Clinical data: use of supplementation measure: Clinical data: use of medication measure: Clinical data: previous muscle injuries measure: Physiological data measure: Anthropometric data: weight measure: Anthropometric data: height measure: Anthropometric data: body mass index measure: Anthropometric data: fat mass percentage measure: Anthropometric data: muscle mass percentage sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Fundació Eurecat, Center for Omic Sciences city: Reus state: Tarragona zip: 43204 country: Spain name: Nuria Canela, PhD role: CONTACT phone: +34977300431 email: nuria.canela@eurecat.org name: Anna Crescenti, PhD role: CONTACT phone: +34977770958 phoneExt: 4832 email: anna.crescenti@eurecat.org lat: 41.15612 lon: 1.10687 hasResults: False
nctId: NCT06365307 id: Histograft-SF-2023 briefTitle: Comparative Study of Gene-Activated Bone Substitute "Histograft" for Lumbar and Cervical Spinal Fusion overallStatus: RECRUITING date: 2023-11-13 date: 2024-04 date: 2025-04 date: 2024-04-15 date: 2024-04-15 name: Histograft Co., Ltd. class: INDUSTRY name: Petrovsky National Research Center of Surgery briefSummary: The goal of this clinical trial is to evaluate the safety and efficacy of the combination product "Histograft", a bone substitute based on octacalcium phosphate (OCP) and plasmid DNA encoding VEGFA gene, in spinal fusion prosedure in comparison with bone autografts and synthetic material based on β-TCP conditions: Cervical Disc Disorder With Radiculopathy conditions: Spinal Stenosis conditions: Lumbar and Other Intervertebral Disc Disorders With Radiculopathy conditions: Biomechanical Lesion, Unspecified studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: During the preliminary screening and indication for surgical treatment, patients are divided into 2 groups depending on the location of the pathological process: 1 - cervical spine, 2 - lumbar spine. During independent sequential randomization in a 1:1 ratio, patients in each of these groups are divided into clinical (A) and control (B) groups.
2B - use of bone autograft for spinal fusion of the lumbar spine, 100 patients primaryPurpose: TREATMENT masking: NONE count: 300 type: ESTIMATED name: Osteoplastic material based on octacalcium phosphate and biologically active nucleic acids for bone tissue regeneration Nucleostim-VEGF ("Histograft") name: Synthetic osteoplastic material based on β-TCP or bone autograft measure: Spinal fusion measure: Adverse events and Severe Adverse Events measure: SF- 36 score (The Short Form-36) measure: Unexpected Adverse Drug Reaction sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Scientific Clinical Center No. 2 of Federal State Budgetary Research Institution "Russian research center of surgery named after academician B.V.Petrovsky" status: RECRUITING city: Moscow state: Moscow Oblast zip: 117588 country: Russian Federation name: Renat Nurmukhametov role: CONTACT email: ethic@med.ru name: Mark Aleksanyan role: CONTACT name: Renat Nurmukhametov, MD role: PRINCIPAL_INVESTIGATOR lat: 55.75222 lon: 37.61556 hasResults: False