hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06284876 id: IY-NTNS03 briefTitle: Study to Evaluate the Efficacy and Safety of Ilaprazole 10 mg in Prevention NSAIDs Associated Peptic Ulcer overallStatus: NOT_YET_RECRUITING date: 2024-08-30 date: 2026-08-30 date: 2027-02-28 date: 2024-02-29 date: 2024-02-29 name: Il-Yang Pharm. Co., Ltd. class: INDUSTRY briefSummary: To demonstrate the non-inferiority of Ilaprazole 10 mg to the active control in prevention of NSAIDs-associated peptic ulcer, as assessed by the proportion of subjects with peptic ulcer by Week 24 conditions: Peptic Ulcer studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 416 type: ESTIMATED name: Ilaprazole name: Lansoprazole name: Ilaprazole Placebo name: Lansoprazole Placebo measure: Ilaprazole, Lansoprazole peptic ulcer measure: Ilaprazole, Lansoprazole peptic ulcer measure: Ilaprazole, Lansoprazole GI bleeding sex: ALL minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chung Ang University Hospital city: Seoul country: Korea, Republic of lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06284863 id: 04-2023-200315 briefTitle: Impact Of Nutritional Education Program In Hemodialysis Patients overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-03 date: 2026-04 date: 2024-02-29 date: 2024-02-29 name: Assiut University class: OTHER briefSummary: The study aims to improve the health status of chronic renal failure patients on hemodialysis using nutritional education program on quality of life anserum d electrolytes level by application of physical and clinical evaluation and some biochemical analysis before and after a specified nutritional program conditions: Hemodialysis Complication studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 100 type: ESTIMATED name: Natritional Education Program In Hemodialysis Patients measure: The percentage patients responded to nutritional education program on hemodialysis patients. sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
nctId: NCT06284850 id: Christina Trakatelli briefTitle: Empagliflozin and Red Blood Cell 2,3-biphosphoglycerate Levels overallStatus: RECRUITING date: 2023-11-30 date: 2025-11 date: 2025-11 date: 2024-02-29 date: 2024-02-29 name: Aristotle University Of Thessaloniki class: OTHER briefSummary: The aim of this study is to investigate the hypothesis that treatment with empagliflozin may have an impact on red blood cell 2,3-biphosphoglycerate levels affecting tissue oxygen supply and thus mediating part of the cardio- and reno- protective effect of SGLT-2 inhibitors. conditions: Hematocrit Change conditions: Cardiovascular Prevention conditions: Empagliflozin conditions: SGLT2-Inhibitors conditions: Tissue Oxygenation studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 40 type: ESTIMATED name: Empagliflozin10Mg Tab measure: Mean change in red blood cell 2,3-biphosphoglycerate levels (μmol/ml) measure: Mean change in Hct (%) measure: Hb (mg/dl) measure: RBC (x1000000/μl) measure: MCV (fl), measure: HbA1c (%, mmol/mol), measure: erythropoietin (mU/ml) measure: eGFR (ml/min/1.73m2), measure: Urine Albumin to Creatinine Ratio (mg/g) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Papageorgiou General Hospital status: RECRUITING city: Thessaloniki state: Central Macedonia zip: 56403 country: Greece name: KONSTANTINOS KITSIOS, MD,MSc,PhD role: CONTACT phone: +306977295744 email: kitsios_k@yahoo.gr lat: 40.64361 lon: 22.93086 hasResults: False
nctId: NCT06284837 id: HREC/99382/Alfred-2023 briefTitle: Secondary Access - FEmoral or Radial in Transcatheter Aortic Valve Implantation? acronym: SAFER-TAVI overallStatus: RECRUITING date: 2023-12-04 date: 2025-07 date: 2025-08 date: 2024-02-29 date: 2024-03-04 name: The Alfred class: OTHER name: Epworth Healthcare name: Cabrini Health briefSummary: Transcatheter aortic valve implantation (TAVI) is a well known safe treatment for severe aortic stenosis. To perform TAVI safely, there is a need for two vascular entry (access) sites: the primary and secondary access sites. While the femoral approach remains the most common site for primary access, secondary access (which is needed for guidance during the procedure) has drawn little attention in trials of TAVI. The two secondary access sites most commonly used are the radial (through an artery in the wrist) and femoral (through an artery in the groin) access sites. Observational studies comparing the two have shown a lower risk of complications with radial access compared to femoral access, but there are no randomized controlled data to confirm these findings. Accordingly, investigators aim to undertake a multicenter, randomized controlled trial among patients who are undergoing transfemoral TAVI, to assess if radial access is superior to femoral access as a secondary access site. conditions: Valve Stenoses, Aortic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 560 type: ESTIMATED name: Access site measure: All bleeding and vascular complications measure: All bleeding measure: All vascular complications measure: All-cause death measure: Stroke measure: Myocardial infarction measure: Major adverse cardiovascular events measure: Length of stay post-procedure measure: Overall procedure duration measure: Radiation dose measure: Conversion rate to alternative vascular access site measure: Tertiary site utilised to treat vascular complication measure: Failure to perform angiogram of primary access site at completion of TAVI sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Alfred Health status: RECRUITING city: Melbourne state: Victoria zip: 3004 country: Australia name: Jennifer Zhou, MBBS, BMedSc role: CONTACT email: je.zhou@alfred.org.au name: Antony Walton, MBBS role: PRINCIPAL_INVESTIGATOR name: Dion Stub, MBBS, PhD role: PRINCIPAL_INVESTIGATOR lat: -37.814 lon: 144.96332 facility: Epworth Healthcare status: NOT_YET_RECRUITING city: Melbourne state: Victoria zip: 3121 country: Australia name: Jennifer Zhou, MBBS, BMedSc role: CONTACT email: je.zhou@alfred.org.au name: Antony Walton, MBBS role: PRINCIPAL_INVESTIGATOR lat: -37.814 lon: 144.96332 facility: Cabrini Health status: NOT_YET_RECRUITING city: Melbourne state: Victoria zip: 3144 country: Australia name: Jennifer Zhou, MBBS, BMedSc role: CONTACT email: je.zhou@alfred.org.au name: Dion Stub, MBBS, PhD role: PRINCIPAL_INVESTIGATOR lat: -37.814 lon: 144.96332 hasResults: False
nctId: NCT06284824 id: DPS-JMP-2022-040 briefTitle: Comparison of Two Robotic-Assisted Total Knee Arthroplasty Systems overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-05 date: 2027-05 date: 2024-02-29 date: 2024-04-17 name: Southeast Orthopedic Specialists class: NETWORK name: DePuy Orthopaedics name: Stryker Orthopaedics briefSummary: The goal of this prospective study is to compare two different knee replacement robots. This study will look at patient reported outcome measures and data collected during the operation. The main questions this study aims to answer include:
* Will the intraoperative data differ between the two groups? Participants will undergo total knee replacement with one of the two robots, complete standardized surveys, and have x-rays taken. conditions: Knee Osteoarthritis conditions: Knee Arthritis conditions: Knee Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 120 type: ESTIMATED name: Stryker Triathlon with MAKO Robotic-Arm name: DePuy Attune with VELYS Robotic-Assistance measure: KSS measure: KSS measure: KSS measure: KSS measure: KOOS JR measure: KOOS JR measure: KOOS JR measure: KOOS JR measure: FJS-12 Knee measure: FJS-12 Knee measure: FJS-12 Knee measure: Operative step time measure: Bone resected measure: Costs for surgery sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06284811 id: 050.06.04/155 briefTitle: Massage and Percussion Therapy on Muscle and Performance Parameters overallStatus: RECRUITING date: 2023-12-31 date: 2024-04-15 date: 2024-04-20 date: 2024-02-29 date: 2024-02-29 name: Acibadem University class: OTHER name: Istanbul Aydın University name: Biruni University briefSummary: DOMS, muscle viscoelastic properties, quadriceps strength and vertical jump performance will be evaluated in physically active individuals before the exercise and after the exercise and intervention which is either Swedish massage or Percussion therapy conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 24 type: ESTIMATED name: Exercise program focusing on quadriceps measure: Muscle tone/tension(Hz) measure: Muscle dynamic stiffness (N/m) measure: Muscle elasticity (log) measure: DOMS measure: Vertical Jump Performance measure: Quadriceps isometric strength sex: ALL minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Acibadem University status: RECRUITING city: Istanbul state: Ataşehir zip: 34752 country: Turkey name: Özge Haklı, Research Assisstant role: CONTACT phone: +902165004221 email: ozge.kocaer@acibadem.edu.tr lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06284785 id: 2023.0121 briefTitle: The Effects of Bariatric Surgery on Kidney Oxygenation in Obese Adults With Type 2 Diabetes and Hyperfiltration acronym: ECSTASY overallStatus: RECRUITING date: 2023-08-01 date: 2026-01-01 date: 2026-03-01 date: 2024-02-29 date: 2024-02-29 name: Amsterdam UMC, location VUmc class: OTHER name: Dutch Kidney Foundation name: Dutch Diabetes Research Foundation briefSummary: In this study the investigators will examine the effects of VAT reduction by bariatric surgery on kidney hypoxia and compare kidney oxygenation before- and after surgery in both sexes using BOLD-MRI and measures of kidney hemodynamic function. Furthermore, the investigators will assess whether kidney oxygenation is reduced in obese T2D men and women versus various controls as described below. This will determine whether kidney hypoxia can be appointed as a modifiable pathogenic factor in early DKD and non-surgical interventions targeting kidney hypoxia can be designed to slow DKD progression. conditions: Kidney Hypoxia conditions: Diabetes Mellitus, Type 2 studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Bariatric surgery measure: Difference in kidney oxygenation before and after bariatric surgery measure: Difference in kidney oxygenation between men and women measure: Difference in kidney oxygenation between obese, hyperfiltering men and women with T2D versus non-diabetic lean controls sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: VU University Medical Center status: RECRUITING city: Amsterdam state: Noord-Holland zip: 1081HV country: Netherlands name: Daniel H van Raalte, MD role: CONTACT phone: +31 204442974 email: d.vanraalte@vumc.nl name: Daniel H van Raalte, MD role: PRINCIPAL_INVESTIGATOR lat: 52.37403 lon: 4.88969 hasResults: False
nctId: NCT06284772 id: 4457/2023 briefTitle: FINRISK 2002 Re-examination overallStatus: ENROLLING_BY_INVITATION date: 2023-11-13 date: 2024-06-25 date: 2024-06-25 date: 2024-02-29 date: 2024-02-29 name: University of Turku class: OTHER name: Finnish Institute for Health and Welfare briefSummary: The project aims to fill in the existing gaps in the study of the microbiome as a cardiometabolic driver 1) by determining the key demographic, environmental, genetic, dietary, and metabolic correlates of long-term within-individual microbiome and microbial metabolite changes; and 2) by assessing how the gut microbiome, microbial metabolites, and their long-term changes are prospectively related to the risk factors, surrogate markers, and overt outcomes of CMD. To achieve this goal, repeat stool samples will be collected of \~2300 Finnish individuals who gave stool samples in the year 2002. In addition, \~300 individuals will undergo a in-depth health examination in 2024. conditions: Cardiometabolic Syndrome conditions: Cardiovascular Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2300 type: ESTIMATED name: Questionnaire and fecal sampling name: Health examination measure: Gut microbiome change between 2002-2024 measure: Correlates of gut microbiome change between 2002-2024 sex: ALL minimumAge: 47 Years maximumAge: 96 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Turku city: Turku zip: 20100 country: Finland lat: 60.45148 lon: 22.26869 hasResults: False
nctId: NCT06284759 id: E-77082166-302.08.01-380534 briefTitle: The Effect of Tele-Nursing Application on Self-Care Ability and Daily Living Activities in Fracture Surgery Patients overallStatus: ACTIVE_NOT_RECRUITING date: 2023-09-15 date: 2024-03-28 date: 2024-03-28 date: 2024-02-29 date: 2024-02-29 name: Gazi University class: OTHER name: Lokman Hekim Üniversitesi name: Ankara City Hospital Bilkent briefSummary: This study aims to determine the effect of tele-nursing application based on Orem's Self-care Theory on self-care agency and daily living activities in trauma-related lower extremity fracture surgery patients. conditions: Lower Extremity Fracture studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: In the study, the statistician was blinded using the blind technique. whoMasked: OUTCOMES_ASSESSOR count: 52 type: ACTUAL name: post-discharge telenursing intervention measure: Self Care, Assessed using the Self-Care Agency scale. measure: Activities of daily living, Assessed using the Katz index of independence in activities of daily living (ADL) scale. measure: Instrumental activities of daily living, Assessed using the The Lawton instrumental activities of daily living scale. sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Lokman Hekim University city: Ankara zip: 06510 country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06284746 id: 301Qiaoz briefTitle: Tirelizumab Combined With Chemotherapy in the Treatment of HER-2 Negative Locally Advanced Gastric Cancer overallStatus: RECRUITING date: 2023-10-01 date: 2025-04-30 date: 2025-07-30 date: 2024-02-29 date: 2024-02-29 name: Lin Chen class: OTHER briefSummary: This study objectively analyzes the safety and survival evaluation of perioperative immunotherapy combined with chemotherapy in locally advanced gastric cancer patients through a prospective randomized controlled trial research method; By comparing the pathological response rate, disease-free survival rate, and incidence of adverse events between the combination therapy and chemotherapy alone group, we aim to verify the efficacy and safety of tirelizumab combined with SOX/XELOX chemotherapy in disease control of locally advanced gastric cancer patients, laying the foundation and providing a basis for large-scale multicenter clinical research. conditions: Locally Advanced Gastric Carcinoma conditions: HER2 Negative conditions: Efficacy conditions: Safety studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Tirolizumab+SOX/XELOX name: SOX/XELOX measure: Pathological complete response (pCR) measure: Objective Response Rate（ORR） measure: Disease-free survival（DFS） measure: Overall survival（OS） measure: Major Pathologic Response（MPR） measure: The incidence of adverse events during treatment sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: General Surgery Institute, China PLA General Hospital status: RECRUITING city: Beijing state: Beijing zip: 100853 country: China name: Yunhe Gao, Ph.D. role: CONTACT phone: 86-010-66937164 email: gaoyunhe@301hospital.org lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06284733 id: P.T.REC/012/004874 briefTitle: Whole-body Vibration Without Visual Feedback on Postural Steadiness in Unilateral Trans-femoral Traumatic Amputees overallStatus: COMPLETED date: 2023-11-05 date: 2024-04-08 date: 2024-04-20 date: 2024-02-29 date: 2024-04-23 name: MTI University class: OTHER briefSummary: This study will investigate the effects of Whole-body vibration without visual feedback on postural steadiness in unilateral trans-femoral traumatic amputees. This study will be carried out at the outpatient clinic of the faculty of physical therapy, modern university for technology and information, and El Wafaa wel Amal hospital.
All participants will sign a written consent form after receiving full information about the purpose of the study, procedure, possible benefits, privacy, and use of data. conditions: Amputation; Traumatic, Leg, Lower studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: They will be assigned into three equal groups: primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Double blinded whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 115 type: ACTUAL name: Whole-body vibration plus conservative care name: conservative care measure: Prosthetic leg stability test measure: Sway Index measure: Limits of Stability Test sex: ALL minimumAge: 40 Years maximumAge: 55 Years stdAges: ADULT facility: Ahmed Mohamed Ahmed Abdelhady city: Cairo country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06284720 id: Project number 144 briefTitle: Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-10-31 date: 2024-10-31 date: 2024-02-29 date: 2024-03-12 name: Universidade Católica Portuguesa class: OTHER name: Clínica NeuroVida (Portugal) briefSummary: Memory complaints are a common symptom among Subjective Cognitive Decline, Mild Cognitive Impairment and Alzheimer disease. Indeed, episodic memory and Alzheimer disease are highly sensitive to aging. Many brain areas become active when we remember an event from the past. The precuneus, part of the posterior system of default mode network, has been identified as a central node of episodic memory retrieval and a central node in various psychiatric and neurological disorders, such as Alzheimer disease. Age-related changes have been consistently found in the default mode network connectivity, occurring within its posterior areas and with the reduction of connectivity between anterior and posterior subnetwork. It has also been found that aging is associated with decreased functional connectivity in the precuneus and posterior cingulate of the default mode network. Furthermore, γ-Aminobutyric acid (GABA), which plays an essential role in regulating brain activity and modulating the default mode network, shows a decrease throughout the normal course of aging, in Mild Cognitive Impairment and Alzheimer disease. It was also verified a link between cognitive decline and the dysfunction of the inhibitory activity of GABAergic interneurons, particularly parvalbumin-positive interneurons, that play a role in control local circuitry, brain networks and memory processing. Parvalbumin interneurons are the fast-spiking interneurons that generate and maintain gamma frequency. Gamma band has been associated with the encoding and retrieval of episodic memory. Impairments of gamma oscillations have been observed in healthy aging, Mild Cognitive Impairment and Alzheimer disease.
By identifying these functional connectivity changes, non-invasive neuromodulation techniques may offer a new strategy for improving cognitive functions. Transcranial Alternating Current Stimulation (tACS) is a form of non-invasive brain stimulation that modulates cortical activity by applying weak, oscillating electrical currents to the cortex via two or more scalp electrodes. By using alternating currents, it is possible to simulate the rhythmic pattern of electrophysiological activity of the brain. tACS can interact with neural firing at behaviorally relevant frequencies linked to memory.
In this randomized, double-blind, sham-controlled, cross-over study, the investigators will evaluate whether stimulation with gamma tACS on the precuneus can improve episodic memory in healthy older adults. conditions: Healthy Older Adults studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: PREVENTION masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 16 type: ESTIMATED name: Gamma tACS (40 Hz) over the precuneus name: Sham tACS over the precuneus measure: Changes in immediate and delayed free recall Auditory Verbal Learning Test scores measure: Changes in immediate free recall and delayed recognition Face-Name Memory Test scores measure: Change in functional connectivity sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Filipa Ribeiro city: Lisbon country: Portugal name: Filipa Ribeiro, PhD role: CONTACT phone: +351 217214147 email: filipa.nc.ribeiro@ucp.pt name: Joana Macedo, MSc role: PRINCIPAL_INVESTIGATOR name: Filipa Ribeiro, PhD role: PRINCIPAL_INVESTIGATOR lat: 38.71667 lon: -9.13333 hasResults: False
nctId: NCT06284707 id: Rhythmic_PAU_2024 briefTitle: Effect of Rhythmic Gymnastics Training in Children With Down Syndrome overallStatus: RECRUITING date: 2024-03-01 date: 2024-03-08 date: 2024-05-05 date: 2024-02-29 date: 2024-03-08 name: University of Castilla-La Mancha class: OTHER briefSummary: Some of the clinical characteristics of people with Down syndrome (DS) are orthopedic, cardiovascular, neuromuscular, visual, cognitive and perceptual disorders, which directly affect the quality of their movements. Children with DS often have a sedentary lifestyle or low levels of physical activity which exacerbates problems related to obesity and overall physical health. Therefore, the practice of physical exercise in this type of population is essential to improve their health-related physical fitness. The aim of this study was to analyze the influence of an adapted rhythmic gymnastics training program on body composition, tendon architecture and stiffness, and physical capacity in children with DS. conditions: Physical Conditioning, Human studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: TRIPLE maskingDescription: The care provider will be responsible for administering the training program. Two different people will develop swimming training and rhythmic gymnastics training. Each participant will be assigned a code. The researcher will process the data with the code of each participant. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 20 type: ESTIMATED name: swimming training name: rhythmic gymnastics training measure: Body composition measure: Tendon thickness measure: Stiffness tendon measure: Hamstrings flexibility measure: body mass index measure: visceral fat area measure: metabolism measure: tendon elastography measure: balance measure: functional capacity sex: ALL minimumAge: 6 Years maximumAge: 20 Years stdAges: CHILD stdAges: ADULT facility: Universidad de Castilla La Mancha status: RECRUITING city: Toledo zip: 45071 country: Spain name: Paula Esteban-García, PhD role: CONTACT phone: 925 26 88 00 email: paula.esteban@uclm.es lat: 39.8581 lon: -4.02263 hasResults: False