nctId: NCT06346639 id: LithuananianSportsU-17 briefTitle: Effect of a 16-day Hot and Cold Acclimation on Adaptive Responses and Health-related Indicators overallStatus: RECRUITING date: 2024-04-04 date: 2029-04-04 date: 2029-04-04 date: 2024-04-04 date: 2024-04-15 name: Lithuanian Sports University class: OTHER briefSummary: There are no previous studies of the effects of a combination of whole-body immersions in hot and cold baths on adaptive responses and health-related markers. Thus, the primary aim of this project is to determine whether interventions consisting of whole body immersion in hot and cold baths over 16 days develop heat and/or cold adaptation by remodeling thermoregulatory, metabolic, cardiovascular and physiological responses, and the secondary aim is to determine if current cold-hot acclimation has any effects on physical and mental health-related markers. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE maskingDescription: The researchers who will analyze the saliva and venous blood samples will be blinded. count: 31 type: ESTIMATED name: 16-day hot and cold acclimation measure: Change in body mass and body composition (kg) measure: Change in skinfold thickness (mm) measure: Change in body mass index (kg/m^2) measure: Change in body surface area (m^2) measure: Change in substrate oxidation measure: Change in substrate oxidation (g/day) measure: Change in ventilation (l/min) measure: Change in breathing frequency (t/min) measure: Change in resting energy expenditure (kcal/day) measure: Change in metabolic heat production (W) measure: Change in heart rate (bpm) measure: Change in blood pressure (mmHg) measure: Change in mean arterial pressure (mmHg) measure: Change in heart rate variability (ms) measure: Change in heart rate variability (time domain) (ms) measure: Change in heart rate variability (time domain) (Ln) measure: Change in heart rate variability (frequency domain) (ms^2) measure: Change in heart rate variability (frequency domain) (Ln) measure: Change in stroke volume (ml) measure: Change in stroke volume index (ml/m^2) measure: Change in cardiac output index (l/min//m^2) measure: Change in cardiac output index (l/min) measure: Change in contractility index measure: Change in ventricular ejection time (ms) measure: Change in ventricular ejection fraction (percent) measure: Change in end diastolic volume (ml) measure: Change in systemic vascular resistance (dyn.s/cm5.m^2) measure: Change in cardiac work index (kg.m/m^2) measure: Change in early diastolic filling ratio (percent) measure: Change in testosterone concentration (µg/dl) measure: Change in female sex hormones concentration (pg/mL) measure: Change in salivary cortisol concentration (µg/dl) measure: Change in cytokines concentrations (pg/ml) measure: Change in complete blood count (10^9/L) measure: Change in complete blood count (percent) measure: Change in lipid profile (mmol/l) measure: Change in catecholamines concentration (ng/ml) measure: Change in insulin concentration (μIU/ml) measure: Change in glucose tolerance (mmol/l) measure: Change in anxiety and depression (points) measure: Change in plasma metabolites of the kynurenine pathway (μm) measure: Change in body temperature (°C) measure: Change in physiological strain index measure: Change in cold strain index measure: Change in root mean square (RMS) amplitude (mV) measure: Change in pain sensations measure: Change in thermal sensations (points) measure: Change in shivering/sweating (points) measure: Change in thermal comfort (points) measure: Height (m) measure: Change in physical activity (in h) measure: Change in sleep (in h) measure: Change in oxygen saturation (percent) sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Lithuanian Sports University status: RECRUITING city: Kaunas zip: LT-44221 country: Lithuania name: Diana Reklaitienė, PhD role: CONTACT lat: 54.90272 lon: 23.90961 hasResults: False