hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06318689 id: 2023/0211/OB briefTitle: In Situ Exploration of Vascular Function in Vasoplegic Shock Following Cardiac Surgery With Cardiopulmonary Bypass acronym: Vaso-shock overallStatus: RECRUITING date: 2024-02-05 date: 2026-02-05 date: 2026-05-05 date: 2024-03-19 date: 2024-03-19 name: University Hospital, Rouen class: OTHER briefSummary: The goal of this observational study is to assess in situ vascular function, glycocalyx and microcirculation in postoperative vasoplegic shock following cardiac surgery with cardiopulmonary bypass.
Researchers will compare a group of patients with vasoplegic shock against a group without vasoplegic shock in order to study possible alterations in function in the vasoplegic shock group. conditions: Cardiac Surgical Procedures studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 124 type: ESTIMATED measure: Association between the percentage of brachial artery variation measured by the flow-mediated vasodilation method and the presence of vasoplegic shock at incusion. measure: Association between the percentage of brachial artery variation measured by the flow-mediated vasodilation method and the presence of vasoplegic shock at 48 hours. measure: Pefused boundary region (PBR, µm) obtained from Glycocheck with the presence of vasoplegic shock. measure: Microvascular blood flow (10^3 microns^3 / sec / mm^2) obtained from Glycocheck with the presence of vasoplegic shock measure: Total density (number of 10 micron long vessel segments with diameter of 4 to 25 microns per tissue surface area /mm^2) obtained from Glycocheck with the presence of vasoplegic shock measure: Endothelial function markers (Endothelin-1, pg/mL) with the presence of vasoplegic shock measure: Endothelial function markers (syndecan-1, pg/mL) with the presence of vasoplegic shock measure: Endothelial function markers (interleukin-6, pg/mL) with the presence of vasoplegic shock measure: Endothelial function markers (VCAM-1, pg/mL) with the presence of vasoplegic shock measure: Multivariate analysis explaining the occurrence of vasoplegic shock. measure: Multivariate analysis explaining the occurrence of an altered perfused boundary region (µm). sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Rouen University Hospital status: RECRUITING city: Rouen state: Normandie zip: 76000 country: France name: Emmanuel Besnier, MD, PhD role: CONTACT phone: 33232881705 email: emmanuel.besnier@chu-rouen.fr name: Domitille Renard, MD role: CONTACT phone: 33232881705 email: domitille.renard@chu-rouen.fr lat: 49.44313 lon: 1.09932 hasResults: False
nctId: NCT06318676 id: CA057-1009 briefTitle: A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2025-03-05 date: 2025-03-05 date: 2024-03-19 date: 2024-03-19 name: Celgene class: INDUSTRY briefSummary: The purpose of this study is to evaluate the drug levels of mezigdomide in participants with renal impairment. conditions: Renal Impairment studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 32 type: ESTIMATED name: Mezigdomide measure: Maximum observed concentration (Cmax) measure: Area under the plasma concentration-time curve (AUC) measure: Area under the plasma concentration-time curve from time 0 to time of last quantifiable concentration (AUC(0-T)) measure: Number of participants with adverse events (AEs) measure: Number of participants with serious adverse events (SAEs) measure: Number of participants with physical examination findings measure: Number of participants with vital sign abnormalities measure: Number of participants with 12-lead electrocardiogram (ECG) findings measure: Maximum observed concentration (Cmax) measure: Time of maximum observed concentration (Tmax) measure: Area under the plasma concentration-time curve (AUC) sex: ALL minimumAge: 18 Years maximumAge: 82 Years stdAges: ADULT stdAges: OLDER_ADULT facility: PANAX city: Miami Lakes state: Florida zip: 33014 country: United States name: Robert Perry, Site 0002 role: CONTACT phone: 3056984500107 lat: 25.90871 lon: -80.30866 facility: Local Institution - 0003 city: Orlando state: Florida zip: 32808 country: United States name: Site 0003 role: CONTACT lat: 28.53834 lon: -81.37924 facility: Orlando Clinical Research Center OCRC city: Orlando state: Florida zip: 32809 country: United States name: Thomas Marbury, Site 0001 role: CONTACT phone: 407-257-3462 lat: 28.53834 lon: -81.37924 hasResults: False
nctId: NCT06318663 id: STUDY00007685 briefTitle: Survivor Mom Companion Comparison Study acronym: SMC overallStatus: RECRUITING date: 2023-12-12 date: 2024-12-12 date: 2024-12-12 date: 2024-03-19 date: 2024-03-20 name: State University of New York at Buffalo class: OTHER briefSummary: The overall goal of the SMC is to help reduce posttraumatic stress symptomology for pregnant persons with a history of trauma. conditions: Posttraumatic Stress Symptom studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Survivor Mom Companion measure: Childhood Trauma Questionnaire measure: Primary Care Post Traumatic Stress Disorder Screen for Diagnostic and Statistical Manual of Mental Disorders-5 measure: Adverse Childhood Experiences Questionnaire measure: Post Traumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental Disorders measure: Dissociative Subtype of Post Traumatic Stress Scale measure: Patient Health Questionnaire-9 measure: State Trait Anger Expression Inventory measure: Symptoms Checklist-90 Revised/Interpersonal Sensitivity Subscale measure: Difficulties in Emotion Regulation Scale Short Form sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Buffalo Prenatal-Perinatal Network status: RECRUITING city: Buffalo state: New York zip: 14203 country: United States name: LuAnne Brown role: CONTACT email: lb@bppn.org lat: 42.88645 lon: -78.87837 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-08-28 uploadDate: 2024-03-15T14:52 filename: Prot_SAP_000.pdf size: 217043 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-08-28 uploadDate: 2024-03-15T14:53 filename: ICF_001.pdf size: 270737 hasResults: False
nctId: NCT06318650 id: 19124PER6_3_1 briefTitle: Post Extraction Changes After Ridge Preservation Using Allogeneic Dentin Matrix Vs Demineralized Freeze Dried Allograft overallStatus: RECRUITING date: 2024-02-01 date: 2024-06-01 date: 2024-12-01 date: 2024-03-19 date: 2024-03-19 name: Cairo University class: OTHER briefSummary: the aim of this study is to establish if there are clinical, radio-graphical and histomorphometrical differences between using Allogenic Demineralized Dentin matrix versus Demineralized Freeze-Dried Bone Allograft (DFDBA) as a clinical application in alveolar bone regeneration procedures related to implant dentistry, including socket preservation, alveolar ridge augmentation, after tooth extraction in the esthetic zone.Will ridge preservation using Allogeneic Dentin Matrix be more effective than Demineralized Freeze-Dried Bone Allograft in managing the post extraction hard tissue alterations?
For both groups, All the subjects will be evaluated at pre-surgical, baseline and 6 months post surgical months for clinical parameters and baseline( immediate post-surgical and 6 months post-surgical . Outcomes: Change in ridge width clinically after 6 months, Change in the radiographic buccal vertical bone level, Change in the radiographic palatal vertical bone level,Change in the radiographic horizontal bone level,Percentage of new vital bone formation,Percentage of residual bone graft and Implant Primary Stability. conditions: Socket Preservation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A Randomized Controlled Clinical Trial primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 22 type: ESTIMATED name: Demineralized Dentin Matrix name: Demineralized freeze-dried bone allograft (DFDBA) measure: Change in Ridge width over 6 months measure: Change in the radiographic vertical bone level measure: Change in the radiographic horizontal bone level measure: Percentage of new vital bone formation and residual graft measure: Implant Primary Stability sex: ALL minimumAge: 20 Years maximumAge: 55 Years stdAges: ADULT facility: Faculty of Dentistry Cairo University status: RECRUITING city: Cairo zip: 12613 country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06318637 id: CCSSKB005432 briefTitle: A Study to Evaluate the Acceptability and Feasibility of a Bedtime Routine for Neonates overallStatus: NOT_YET_RECRUITING date: 2024-03-21 date: 2024-12-23 date: 2024-12-23 date: 2024-03-19 date: 2024-03-19 name: Johnson & Johnson Consumer Inc. (J&JCI) class: INDUSTRY briefSummary: The purpose of this study is to assess, via caregiver questionnaire, the acceptability and feasibility of implementing a bedtime routine for newborns. conditions: Newborn studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 100 type: ESTIMATED name: Baby Wash/Shampoo name: Daily Activities name: Body Lotion measure: Bedtime Routine Acceptability and Feasibility to Caregivers measure: Bedtime Routine Acceptability and Feasibility to Caregivers measure: Bedtime Routine Acceptability and Feasibility to Caregivers measure: Bedtime Routine Acceptability and Feasibility to Caregivers sex: ALL minimumAge: 2 Weeks stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: SGS North America, Inc. city: Richardson state: Texas zip: 75081 country: United States lat: 32.94818 lon: -96.72972 hasResults: False
nctId: NCT06318624 id: KHSU-2023/11 briefTitle: Immediate Effects of Ankle MWM and Taping on Gait and Balance in Stroke Patients overallStatus: RECRUITING date: 2024-02-14 date: 2024-09-15 date: 2024-10-11 date: 2024-03-19 date: 2024-03-19 name: Kutahya Health Sciences University class: OTHER briefSummary: Disorders caused by stroke may lead to significant limitations, especially in ankle range of motion, and may cause impairments in walking and balance functions. This limitation in ankle range of motion leads to difficulties in weight transfer, stability, and balance. As a result, there is a decrease in walking performance and an increased risk of falls. Various interventions have been used to improve ankle dorsiflexion passive range of motion, including gastrosoleus muscle stretching, muscle strengthening training, functional electrical stimulation training, proprioceptive control training, taping, manual therapy, different mobilization techniques, and ankle mobilization with motion (MWM).There are limited studies investigating the immediate effects of MWM and taping on gait and balance in stroke patients. This study was planned to investigate the effect of Mulligan's ankle MWM technique and talus stabilization taping on spatiotemporal gait and balance parameters in stroke patients. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: There are 2 different groups in the study. One of them is the intervention group and the other is the sham group. whoMasked: PARTICIPANT count: 100 type: ESTIMATED name: Mobilisation with Movement and Taping name: Sham measure: Stride length measure: Stride width measure: Cadance measure: Walking speed measure: The symmetry of the center of pressure changes during walking measure: The maximum force on the feet during walking measure: The distribution of pressure on the feet measure: Balance measure: 10-meter walk test measure: Timed up and go test sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kutahya Health Sciences University status: RECRUITING city: Kütahya zip: 43100 country: Turkey name: Fatıma Yaman, PhD, MD role: CONTACT phone: +905066802926 email: fatimacakir84@hotmail.com name: Berna Kılıç, PT role: SUB_INVESTIGATOR lat: 39.42417 lon: 29.98333 hasResults: False
nctId: NCT06318611 id: 09.2022.575 briefTitle: Sleep Patterns and Chronotype in Children With and Without Type 1 Diabetes overallStatus: COMPLETED date: 2022-05-01 date: 2023-05-01 date: 2023-05-01 date: 2024-03-19 date: 2024-03-19 name: Koç University class: OTHER name: Marmara University briefSummary: Type 1 diabetes (T1D) is one of the most common chronic childhood diseases. Recent studies have highlighted the strong association between type 1 diabetes and sleep health problems. Sleep problems have been reported to include sleep onset, sleep maintenance, frequent nighttime awakenings, and daytime sleepiness. Studies show that children with T1D sleep significantly less than their peers without diabetes, and that this is associated with poorer glycemic control in type 1 diabetes due to impaired glucose metabolism.
The sleep health composite dimensions were measured using actigraphy, sleep diaries, and self- or parental reports. Sleep disturbance will be assessed using the Diagnostic and Statistical Manual for Mental Disorders (DSM-5) Level 2-Sleep Disturbance Scale Short Form, and the Children's Chronotype Questionnaire will be used to determine the chronotype. Sleep/wake patterns were also assessed using sleep diaries. Glycemic variability was assessed using continuous glucose monitoring (CGM) device parameters. conditions: Type1diabetes conditions: Sleep conditions: Chronotype studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 168 type: ACTUAL name: sleep, chronotype measure: Sleep health composite measure: Chronotype measure: Glycemic variability measure: Glycemic control sex: ALL minimumAge: 6 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Necla İpar city: İstanbul zip: 34010 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06318598 id: 23M202 briefTitle: Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis acronym: DRIVEALS overallStatus: RECRUITING date: 2023-04-11 date: 2026-04-10 date: 2026-04-10 date: 2024-03-19 date: 2024-03-19 name: Istituto Auxologico Italiano class: OTHER name: Azienda Ospedaliera Città della Salute e della Scienza di Torino name: Ospedale San Raffaele briefSummary: The goal of this observational study is to understand the clinical variability in a population of ALS patients using multidimensional biomarkers. The main questions it aims to answer are:
* biomarker measurement in CSF and plasma conditions: Amyotrophic Lateral Sclerosis conditions: Motor Neuron Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: genetic screening measure: biomarker assessment measure: clinical assessment measure: neuropsychological assessment sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ospedale San Raffaele status: RECRUITING city: Milano state: MI zip: 20132 country: Italy name: Yuri Falzone, MD, PhD role: CONTACT lat: 45.46427 lon: 9.18951 facility: Ospedale San Luca status: RECRUITING city: Milano state: MI zip: 20149 country: Italy name: Alberto Doretti, MD role: CONTACT phone: +0261911 phoneExt: 2937 email: a.doretti@auxologico.it lat: 45.46427 lon: 9.18951 facility: AOU Città della Salute e della Scienza status: RECRUITING city: Torino state: TO zip: 10126 country: Italy name: Adriano Chiò, MD role: CONTACT lat: 45.07049 lon: 7.68682 hasResults: False
nctId: NCT06318585 id: 23C306 briefTitle: Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases acronym: ALS-PHENO overallStatus: RECRUITING date: 2023-04-03 date: 2026-12-31 date: 2026-12-31 date: 2024-03-19 date: 2024-03-19 name: Istituto Auxologico Italiano class: OTHER briefSummary: Study Description: Characterization of Motor Neuron Disease Phenotypes
* Collection of biological materials for genetic screening and biomarker assessment, if necessary. conditions: Amyotrophic Lateral Sclerosis conditions: Motor Neuron Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: no. of patients with classic ALS measure: no. of patients with bulbar ALS measure: no. of patients with LMN phenotypes (flail arm, flail leg, PMA) measure: no. of patients with UMN phenotypes (pyramidal ALS, PLS) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ospedale San Luca status: RECRUITING city: Milano state: MI zip: 20149 country: Italy name: Alberto Doretti, MD role: CONTACT phone: +0261911 phoneExt: 2937 email: a.doretti@auxologico.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06318572 id: PR(AG)166/2021 briefTitle: Development of Self-administrable Psychological Intervention Programs Supported by New Technologies as a Treatment for Patients With Functional Digestive Disorders. overallStatus: RECRUITING date: 2023-03-09 date: 2024-12-30 date: 2025-04-30 date: 2024-03-19 date: 2024-03-19 name: Hospital Universitari Vall d'Hebron Research Institute class: OTHER briefSummary: Disorders of gut-brain interaction (DGBI) are produced by disturbances in the interplay between the gut and the central nervous system. Several psychological factors like anxiety, depression and altered coping are over-represented in these disorders. Recent surveys have shown that DGBI affect up to 40 % of the general population.
METHODOLOGY: After development of a program of psycho-education on DGBI using interactive immersion by means of virtual reality (VR) a randomized clinical trial will be developed. Consecutive patients will be randomized 1:1 to active treatment or placebo. In each patient in the active treatment group a session of psychoeducation using specifically developed VR-video leaded by a gastroenterologists, will be followed by telematic weekly group sessions of psycho-education leaded by a psychologist. During the 6 weeks of the treatment period patients will be instructed to perform self-administrable sessions of psychotherapy at home (by means VR). Patients in the placebo group willl take a placebo capsule daily.
OUTCOME MEASURES. In all patients, severity of symptoms (primary outcome), QoL, somatic and psychological comorbidities (using specific questionnaires), visceral sensitivity (by means of a barostat) and microbiota analysis, will be performed before and at the end of the treatment period. Symptom severity will be assess also in follow-up phone calls at 3 and 6 months. conditions: Irritable Bowel Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 100 type: ESTIMATED name: Psychological intervention name: Placebo measure: Severity of abdominal symptoms measure: IBS related Quality of life measure: Stress measure: Anxiety and depression measure: Somatic co-morbidities measure: Rectal sensitivity measure: Analysis of gut microbiota composition sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Universitari Vall d'Hebron status: RECRUITING city: Barcelona zip: 08035 country: Spain name: Jordi Serra, MD role: CONTACT phone: 34 932746259 email: jordi.serra@vallhebron.cat role: CONTACT email: jordi.serra@vallhebron.cat lat: 41.38879 lon: 2.15899 hasResults: False
nctId: NCT06318559 id: 027-FPO22 briefTitle: Artificial Intelligence 3D Augmented Reality Robot-Assisted-Radical- Prostatectomy v.s. no3D Intervention acronym: RIDERS overallStatus: RECRUITING date: 2022-06-29 date: 2025-12-31 date: 2027-12-31 date: 2024-03-19 date: 2024-03-19 name: Fondazione del Piemonte per l'Oncologia class: OTHER name: San Luigi Gonzaga Hospital briefSummary: This is a prospective randomized multicenter study aimed at comparing 3D AI-AR-RARP vs. no 3D, verifying the impact of this new technology on oncological and functional outcomes after the procedure. conditions: Cancer of Prostate studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients will be randomized using an Excel® macro in 2 group: 3D and no3D, stratifying them by age, PSA, cT, PSA density, prostate volume, lesion volume, extracapsular extension (ECE), seminal vesicle invasion (SVI), biopsy ISUP. primaryPurpose: DIAGNOSTIC masking: NONE count: 120 type: ESTIMATED name: 3D Robot-assisted laparoscopic radical prostatectomy and pelvic lymphadenectomy measure: Perioperative surgical oncological outcomes measure: Micturition outcomes measure: Sexual function outcomes measure: Oncological outcomes measure: Verify the potential application of AI sex: MALE minimumAge: 40 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione del Piemonte per l'Oncologia-IRCCS Candiolo status: RECRUITING city: Candiolo state: Turin zip: 10060 country: Italy name: Enrico Checcucci, MD role: CONTACT phone: +390119933632 email: enrico.checcucci@ircc.it lat: 44.95858 lon: 7.59812 facility: AOU san Luigi Gonzaga status: RECRUITING city: Orbassano state: Turin zip: 10060 country: Italy name: Francesco Porpiglia, MD role: CONTACT lat: 45.00547 lon: 7.53813 hasResults: False
nctId: NCT06318546 id: FMASU MS59/2024 briefTitle: Dexmedetomidine in Spinal Anesthesia Decreasing Post Spinal Shivering in Caesarean Section overallStatus: NOT_YET_RECRUITING date: 2024-04-03 date: 2024-10 date: 2024-11 date: 2024-03-19 date: 2024-04-01 name: Ain Shams University class: OTHER briefSummary: The investigators will test the effects of intrathecal dexmedetomidine as adjuvant to intrathecal bupivacaine and it's direct effect in decreasing incidence of post spinal shivering in Parturients Undergoing Caesarean section conditions: Post Spinal Shivering studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: Dexmedetomidine Injection [Precedex],,, name: Fentanyl measure: Post spinal shivering sex: FEMALE minimumAge: 20 Years maximumAge: 35 Years stdAges: ADULT hasResults: False