hackint0sh/New-Dataset huggingface dataset:
Aim 1: To create the CCM-C training program. Aim 2: To assess preliminary training effectiveness. Aim 3: To gather training program quality improvement feedback from corrections stakeholders. conditions: Knowledge, Attitudes, Practice studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: NONE count: 100 type: ESTIMATED name: Core Competency Model for Corrections (CCM-C) Self-Directed Violence Prevention Training measure: Feasibility measure: Acceptability measure: Appropriateness measure: Usability measure: Perceived self-directed violence prevention skills measure: Willingness to intervene with a suicidal person measure: Beliefs about incarcerated persons engaging in self-directed violence measure: Self-directed violence prevention knowledge measure: Perceived importance of training measure: Compassion fatigue: Job burnout measure: Compassion fatigue: Traumatic stress sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: North Carolina Department of Adult Corrections city: Raleigh state: North Carolina zip: 27699 country: United States lat: 35.7721 lon: -78.63861 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-02-14 uploadDate: 2024-03-20T14:21 filename: ICF_000.pdf size: 256435 hasResults: False
nctId: NCT06359561 id: 2023-2201 - Cervical lead briefTitle: Assessment of Effectiveness and Stimulation Coverage of Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy in Patients With Cervical Lead Placement overallStatus: ENROLLING_BY_INVITATION date: 2023-10-05 date: 2025-12-31 date: 2025-12-31 date: 2024-04-11 date: 2024-04-11 name: Rijnstate Hospital class: OTHER name: Saluda Medical Pty Ltd briefSummary: This observational, prospective data collection is designed to evaluate the effectiveness and stimulation coverage of closed-loop spinal cord stimulation (CL-SCS) therapy in patients with cervical lead placement. conditions: Chronic Pain Syndrome conditions: Multi Focal Pain conditions: Failed Neck Surgery Syndrome conditions: Polyneuropathies studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 40 type: ESTIMATED name: cervical lead placement measure: Pain intensity in pain region(s) of pain using the 11-box pain numeric rating scale (NRS) measure: Pain distribution using Patient Reported Dermatomal Coverage Map measure: Assessment of holistic outcomes: quality of life in seven domains (physical function, fatigue, pain interference, depression, anxiety, ability to participate in social roles and activities, and sleep disturbance) assessed by the PROMIS-29 questionnaire measure: Pain-related medication intake. measure: Programming parameters. measure: Programming parameters. measure: Evaluate stimulation sensation (awareness and quality) measure: Evaluate stimulation coverage in pain region(s) measure: Posture Change Measurements sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Rijnstate Hospital city: Arnhem state: Gelderland zip: 6815AD country: Netherlands lat: 51.98 lon: 5.91111 hasResults: False
nctId: NCT06359548 id: XH-24-002 briefTitle: PEELED INTERNAL LIMITING MEMBRANE REPOSITION overallStatus: RECRUITING date: 2024-04-15 date: 2026-06 date: 2026-11 date: 2024-04-11 date: 2024-04-11 name: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine class: OTHER briefSummary: Macular hiatus (MH) refers to a tissue defect in the photoreceptor cell layer of the inner boundary membrane of the optic disc in the macular region. Among them, idiopathic macular hiatus (IMH) is more common in people over 60 years old and is a common eye disease. With the aging of society, the number of patients increases, and it severely damages the patients' vision and life quality. Previously, the conventional surgical approach for treating MH was vitrectomy combined with inner limiting membrane (ILM) peeling. Although the closure rate of MH is high, many damages to the morphology and function of the ILM peeled area have been found. Our team firstly report a novel technique of peeled ILM reposition. Compared to traditional ILM peeling, the novel technique peeled ILM reposition maintains the integrity of internal retina by "pull" back the ILM flap. The previous pilot clinical study suggests that the novel technique peeled ILM reposition surgical intervention can achieve better morphology and functional prognosis. However, there is currently a lack of larger sample size prospective randomized controlled studies to further clarify the clinical efficacy of this new surgical technique in treating IMH. This study aims to conduct a single center, prospective, and randomized controlled study, combined with previous work, to analyze the efficacy of this novel technique peeled ILM peeling in the treatment of IMH. We hypothesize that this novel technique can achieved better morphological and functional prognosis compared to traditional ILM peeling. conditions: Macular Holes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: Peeled ILM Reposition name: ILM Peeling measure: The change in the best corrected visual acuity (BCVA) from baseline to 6 months postoperatively measure: The MH closure rate measure: The range of inner retinal dimpling measure: Postoperative retinal thickness measure: The fixation stability and sensitivity threshold measure: mfERG P1 wave density amplitudes measure: M-score values measure: NEI-VFQ-25 questionnaire scores sex: ALL minimumAge: 50 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Xinhua Hospital Affiliated to Shanghai Jiaotong University Medicine School status: RECRUITING city: Shanghai country: China name: Tian Tian, Dr. role: CONTACT lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06359535 id: HSK21542-IIT-02 briefTitle: An Economic Study of HSK21542 Injection for Prevention of Postoperative Nausea and Vomiting overallStatus: RECRUITING date: 2024-02-23 date: 2024-11-06 date: 2024-11-06 date: 2024-04-11 date: 2024-04-11 name: Mengchang Yang class: OTHER briefSummary: This study analyzed the efficacy and safety results of HSK21542 injection for the prevention of postoperative nausea and vomiting in a multicentre, randomized, double-blind, placebo-controlled dose-exploration study, as well as the real-world clinical routine use of troisisone and other (not limited to other setron drugs) for the prevention of postoperative nausea and vomiting and related adverse reaction treatment data. It was transformed into an effect indicator, and the possible costs involved in the study were analyzed, reasonable price parameters of HSK21542 injection were set, and the economic value of HSK21542 was explored. conditions: Nausea and Vomiting, Postoperative studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 200 type: ESTIMATED name: HSK21542 name: Placebo measure: Total direct medical costs, direct non-medical costs, indirect costs sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Sichuan Provincial People's Hospital status: RECRUITING city: Chengdu state: Sichuan country: China name: Mengchang Yang, Doctor role: CONTACT phone: +8618140049936 email: ymc681@126.com name: Mengchang Yang role: PRINCIPAL_INVESTIGATOR name: Yu He role: SUB_INVESTIGATOR name: Mengxia Lan role: SUB_INVESTIGATOR name: Ai Wei role: SUB_INVESTIGATOR name: Lina Yang role: SUB_INVESTIGATOR lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06359522 id: 22.0334 briefTitle: PDA Occlusion Using NIRS overallStatus: RECRUITING date: 2023-04-18 date: 2025-03-31 date: 2025-09-30 date: 2024-04-11 date: 2024-04-11 name: University of Louisville class: OTHER name: Norton Healthcare briefSummary: Our study will be a prospective observational study of all patients in the Norton Children's Hospital NICU (Neonatal Intensive Care Unit) who undergo a transcatheter PDA occlusion or medical closure of PDA to compare the two populations regarding changes in organ perfusion determined by using NIRS monitoring to follow the regional saturation of oxygen (rSO2) of the cerebral and renal regions. We suspect that medical treatment will have no significant change in rSO2 as described in previous literature. We also suspect that transcatheter occlusion will have minimal effects on rSO2 and be comparable to medical therapy. conditions: Organ Perfusion Determined by Using NIRS Post Transcatheter PDA Occlusion or Medical Closure of PDA studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients who are being treated for PDA closure either via transcatheter occlusion or medical closure as part of routine care are eligible for this study. primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: NIRS monitor measure: Measure changes in rScO2 and SrO2 after TCPC of a PDA and compare to baseline readings. measure: Measure changes in rScO2 and SrO2 after medical closure of PDA with Tylenol. measure: Compare rates of co-morbid conditions between the two groups such as but not limited to necrotizing enterocolitis, feedings intolerance, or failed to extubate within 5 days post treatment. sex: ALL minimumAge: 0 Months maximumAge: 3 Months stdAges: CHILD facility: Norton Children's Hospital status: RECRUITING city: Louisville state: Kentucky zip: 40202 country: United States name: Scott D Duncan, MD role: CONTACT phone: 502-629-5283 email: scottd.duncan@louisville.edu name: Janice E. Sullivan, MD role: CONTACT phone: 502-629-5283 email: sully@louisville.edu name: Joshua D Kurtz, MD role: SUB_INVESTIGATOR name: Joshua Lee, MD role: SUB_INVESTIGATOR name: John N Juneau, MD role: SUB_INVESTIGATOR lat: 38.25424 lon: -85.75941 hasResults: False
nctId: NCT06359509 id: SYS6020-001 briefTitle: Study of SYS6020 in BCMA-positive Multiple Myeloma overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-05 date: 2032-05 date: 2024-04-11 date: 2024-04-11 name: Wuhan Union Hospital, China class: OTHER briefSummary: This is a multi-center, phase I trial that studies the efficacy and recommended dose of BCMA CART cells in treating patients with BCMA-positive multiple myeloma (MM) that have not respond or relapsed after chemotherapy. B-cell maturation antigen (BCMA), a cell surface protein expressed on malignant plasma cell, has emerged as a very selective antigen to be targeted in novel immunotherapy for MM. conditions: Multiple Myeloma studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: BCMA Targeted CAR T-cells measure: Incidence of adverse events (AEs) measure: Dose limiting toxicities (DLTs) measure: Overall response rate (ORR) measure: Percentage of subjects who achieved complete response or strict complete response (CR/sCR) measure: Percentage of subjects who achieved very good partial response (VGPR) and higher response rate sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06359496 id: CT2024-ZJU-OBS8 briefTitle: Split or Whole Liver Transplantation? A Multicenter Retrospective Cohort Study of Patients With Benign and Malignant Liver Disease overallStatus: COMPLETED date: 2024-02-23 date: 2024-04-02 date: 2024-04-02 date: 2024-04-11 date: 2024-04-11 name: Zhejiang University class: OTHER briefSummary: The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and WLT also .
This retrospective study analyze outcomes among adults who underwent SLT and whole liver transplantation (WLT) at two centers from January 2018 to August 2022. A 1:1 propensity score matching (PSM) analysis was performed based on important donor and recipient variables. Baseline characteristics and postoperative outcomes of the above recipients were analyzed and compared. Statistical significance was determined using a two-sided p-value threshold of less than 0.05. conditions: Zhejiang University studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 1 type: ACTUAL name: No intervention factor measure: Postoperative complications were evaluated by postoperative imaging reports and serological indicators measure: The survival rate of each group was evaluated by follow-up survey and K-M curve sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Xiao Xu city: Hangzhou country: China lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06359483 id: 108/2021 briefTitle: The Impact of Meal Frequency on Bone Remodeling in Healthy Adults overallStatus: COMPLETED date: 2021-06-19 date: 2021-07-04 date: 2021-07-04 date: 2024-04-11 date: 2024-04-11 name: University of Jordan class: OTHER name: United Arab Emirates University briefSummary: The study aimed to investigate the effect of meal frequency on bone remodeling using the marker Procollagen Type 1 N-terminal propeptide (P1NP). Thirty healthy adult males from Jordan participated in a randomized controlled intervention trial. They were randomly assigned to three or eight daily meals for three consecutive days over two phases. Blood samples were obtained at the beginning and end of each phase, and P1NP levels were analyzed. The results showed a substantial drop in P1NP levels compared to the baseline, indicating that meal frequency influences bone development. There were no significant changes between the groups eating three and eight meals per day. The study emphasizes the importance of dietary patterns in bone health and advises additional research to understand the relationship between meal frequency and bone metabolism. conditions: Healthy Adults studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: NONE count: 30 type: ACTUAL name: Meal Frequency Manipulation measure: The title of the primary outcome is "Procollagen Type 1 N-terminal propeptide (P1NP) Levels." sex: ALL minimumAge: 19 Years maximumAge: 30 Years stdAges: ADULT facility: University of Jordan city: Amman country: Jordan lat: 31.95522 lon: 35.94503 hasResults: False
nctId: NCT06359470 id: CaiUni briefTitle: the Modified Reversed Contralateral Axial Rotation Position overallStatus: COMPLETED date: 2022-11-05 date: 2023-10-01 date: 2024-01-14 date: 2024-04-11 date: 2024-04-11 name: Noha Khaled Shoukry class: OTHER briefSummary: This study aimed to investigate the effect of specific three-dimensional (3D) positions of the trunk on patients with lumbar discogenic pain with radiculopathy aiming to find a position that directly decompresses the impinged root as well as the effect of this position on the CSA of the L3-L4, L4-L5 and L5-S1 intervertebral foramen (IVF) using 3D-CT scan imaging of the real spine conditions: Disc Prolapse With Radiculopathy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SEQUENTIAL interventionModelDescription: This study was conducted on ninety male patients (30 in each group), ages ranged from 20 - 40 years old, and were diagnosed with unilateral lumbar disc prolapse (group1: L3-L4), (group 2: L4- L5) and (group 3: L5-S1) for at least three months in a radiology center specialized in the spine (Egyscan center). Each group was imaged three times (from the supine position, then from the oblique position after 10 minutes, and finally from the oblique position again after 48 hours). The oblique image was taken during a specific trunk position the modified reversed contralateral rotation (side-lying with side bending to the non-affected side and rotation to non affected side).The CSA of LIVF and SLR test was assessed at the three times of testing primaryPurpose: TREATMENT masking: NONE count: 90 type: ACTUAL name: Positioning technique measure: Straight leg raising test measure: Foraminal cross sectional area sex: MALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Faculty of Physical Therapy city: Giza zip: 12556 country: Egypt lat: 30.00808 lon: 31.21093 hasResults: False
nctId: NCT06359457 id: P.T.REC/012/005016 briefTitle: Correlation Between Serum Progesterone Level And Primary Dysmenorrhea overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-06 date: 2024-07 date: 2024-04-11 date: 2024-04-11 name: Cairo University class: OTHER briefSummary: This study will be conducted to determine Correlation between the levels of serum progesterone and Menstrual Symptoms In Young Females conditions: Primary Dysmenorrhea studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 100 type: ESTIMATED measure: Serum progesterone level measure: Pain intensity measure: Physical and psychological symptoms sex: FEMALE minimumAge: 17 Years maximumAge: 24 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06359444 id: ONZ-2023-0453 briefTitle: Effect of High Intensity Exercise Rehabilitation on Liver Function and Insulin Sensitivity in Patients With MASLD acronym: CENSORIAL overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-03-15 date: 2026-03-15 date: 2024-04-11 date: 2024-04-11 name: University Ghent class: OTHER name: University Hospital, Ghent briefSummary: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide, and is associated with obesity and the metabolic syndrome. Physical activity and lifestyle interventions are among the most recommended treatments for individuals with MASLD.
In this RCT, we will evaluate the effect of combined exercise training "strength and aerobic training" versus "strength and high intensity training (HIIT)". The main outcome parameter is the severity of liver steatosis. Patients will be recruited at the fatty liver clinic of the UZ Gent. conditions: Exercise Therapy conditions: Metabolic Dysfunction-associated Steatotic Liver Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients will be randomized in two groups: (a) combined aerobic and strength and (b) combined high intensity and strength. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: The training will be given by the care provider, but in exercise therapy it is not possible to mask. The assessor will assess the patients without knowing in which group they will be randomized. Randomization will be done by an external person who is only involved for randomization. The investigator, who will be analysing data afterwords, will only see 1 or 2 as group number, but will not know which number is corresponding to which group. whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 92 type: ESTIMATED name: Combined aerobic + strength training name: Combined strength + HIIT training measure: Liver steatosis by CAP measure: Liver steatosis on ultrasound measure: Insulin sensitivity measure: Liver transaminases measure: Maximal exercise test measure: Strength measure: Cardiovascular function measure: Weight measure: Heigth measure: BMI measure: waist measure: BIA measure: Interleukine measure: TNF-alfa measure: Hepatokines measure: Myokines measure: Adipokines measure: SF-36 sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT typeAbbrev: SAP hasProtocol: False hasSap: True hasIcf: False label: Statistical Analysis Plan date: 2024-01-29 uploadDate: 2024-03-23T04:06 filename: SAP_000.pdf size: 133707 hasResults: False
nctId: NCT06359431 id: 1604/CE/CNERSH/SP briefTitle: A Novel Smart Speculum Versus a Standard Speculum for Easy Visualisation of the Cervix and Performing Remote Cervical Cancer Screening overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-06-30 date: 2024-07-30 date: 2024-04-11 date: 2024-04-11 name: GICMED class: OTHER briefSummary: Objective: The main objective of this study is to verify the level of comfort for patients and the degree of cervical visibility for health providers using a novel smart speculum compared to the standard speculum. In addition, establish the feasibility of using this novel smart speculum device with telemedicine for cervical cancer screening in a low-resource setting using VIA compared to the standard of care.
Study design: The study will be a multicentre, randomised control single blind trial. Patient participation will be a single study visit. Eligible subjects, consenting to participate will act as their own controls, and will receive speculum examination and cervical cancer screening with both the novel speculum and a traditional speculum. The order of usage of the specula will be randomised, and the women will be blinded on knowing which speculum is being used at a particular time. Level of patient comfort will be evaluated using a visual analogue scale, percentage visualisation of the cervix will be determined following insertion of each of the specula, and results of cervical cancer screening following VIA screening method will be compared between the standard of care procedure to that using the novel smart speculum associated to telemedicine.
Enrolment size: 81 women will be enrolled in the study. Study procedure: A speculum examination will be done on the day of consultation. Level of patient comfort determined using a visual analogue scale and proportion of the cervix visualised would be recorded into questionnaires. Cervical cancer screening through VIA will be performed with results confirmed on site by the clinician using the standard speculum, while two other clinicians for each case will do a remote diagnosis after reviewing images captured through the novel speculum device and forwarded to them through telemedicine. The remote clinicians will be blinded on the diagnosis proposed by the clinician on site.
Ethical considerations: The protocol will be submitted for the approval of the National Human Health Research Committee. Written informed consent will be sought for all participants before enrolment into the study. conditions: Cervical Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: SCREENING masking: SINGLE whoMasked: PARTICIPANT count: 81 type: ESTIMATED name: Novel Smart Speculum name: Standard speculum measure: Visualization measure: Reliability in cervical cancer screening using a questionnaire sex: FEMALE minimumAge: 21 Years maximumAge: 49 Years stdAges: ADULT hasResults: False
nctId: NCT06359405 id: UBeykentUni briefTitle: Evaluation of Nursing Students' Crisis Management Skills in Medication Safety Simulation acronym: RCS overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2024-05-01 date: 2024-05-02 date: 2024-04-11 date: 2024-04-16 name: University of Beykent class: OTHER briefSummary: This study aims to objectively evaluate student nurses' crisis management skills in drug safety simulation and examine an effective intervention to improve these skills through a randomized controlled study. The research aims to provide important findings that will contribute to the determination of strategies to increase the competencies of student nurses in the fields of drug safety and crisis management.