hackint0sh/New-Dataset huggingface dataset:
Purple sweet potatoes, scientifically known as Ipomoea batatas (L.) Lam., contains of high anthocyanin specifically peonidin and cyanidin that has antioxidant, anti-inflammatory, and potentially phytoestrogenic activity. These anthocyanins have been linked to a reduced risk of obesity, diabetes, and high cholesterol. They also show potential in improving endothelial function, thereby enhancing blood vessel vasomotor function and potentially reducing the risk of cardiovascular diseases. Anthocyanins and their metabolites can cross the blood-brain barrier and affect signaling pathways, gene expression, and protein function at the molecular level. In addition to their ability to enhance vascular flow, anthocyanins can also help mitigate the risk factors associated with CSVD by counteracting oxidative stress in the body. These findings exploring the potential benefits of anthocyanins for individuals with CSVD by giving purple sweet potatoes extract comparing with placebo.
The outcomes that will be assessed are vasomotor reactivity measured by Breath Holding Index in Transcranial Doppler, Nitric Oxide, L-Arginine and Adiponectin levels in blood, Cognitive Test and Gait. conditions: Cerebral Small Vessel Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The participant who meet the inclusion criteria and have signed the consent will be subjected to a baseline assessment followed by randomization into 2 groups/arms consisting of 2 treatments (1 group getting the water extract pf purple sweet potato) and 1 control group that got placebo. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: The research was conducted using a single-blind approach, where the participants were unaware of the intervention being implemented whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: The water extract of "Biang" variety purple sweet potato measure: Breath Holding Index measure: Nitric Oxide measure: L-Arginine measure: Adiponectin measure: Cognitive measure: Gait sex: ALL minimumAge: 40 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-12-02 uploadDate: 2024-04-18T03:49 filename: ICF_000.pdf size: 332637 hasResults: False
nctId: NCT06380452 id: SKABUP id: 2023-507925-41-00 type: OTHER domain: EU-Trial-Nr. (EMA) briefTitle: Therapy for Scabies With Two Differently Concentrated Permethrin Creams acronym: SKABUP overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-07 date: 2028-12 date: 2024-04-23 date: 2024-04-23 name: Infectopharm Arzneimittel GmbH class: INDUSTRY name: Winicker Norimed GmbH briefSummary: The multi-center, prospective, randomized, double-blind phase III clinical trial will primarily investigate the efficacy and safety of treatment of scabies with Permethrin Cream 5% (approved drug InfectoScab 5% Cream) in direct comparison with Permethrin Cream 10%.
The trial participants will be randomly assigned and blinded to either Permethrin Cream 5% or Permethrin Cream 10%. conditions: Scabies studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The SKABUP study is a prospective, randomized, double-blind, 2-arm superiority study in a group sequential design with recruitment stop and interim analysis after 172 patients. If there is no evidence of superiority in the interim analysis, the study will be continued unchanged up to the planned number of 220 patients and will be terminated and analyzed regularly. primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: double-blind whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 220 type: ESTIMATED name: 5% Permethrin Creme name: 10% Permethrin Creme measure: clinical efficacy (yes/no) measure: effectiveness at Visit 1 measure: frequency of therapy success measure: itching measure: patients with evidence of mites measure: patients with use of antiscabiosa not compliant with the protocol measure: patients with new scabies efflorescences measure: patients with "additional confirmed" treatment failure measure: AEs, SAEs, ADRs, SUAWs sex: ALL minimumAge: 2 Years maximumAge: 85 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06380439 id: 23-10-1763 briefTitle: The Effect of Wrist Ankle Acupuncture on Post-Total Hip Arthroplasty Pain overallStatus: RECRUITING date: 2024-04-23 date: 2024-07 date: 2024-07 date: 2024-04-23 date: 2024-04-29 name: Indonesia University class: OTHER briefSummary: Total hip arthroplasty is one of the most cost-effective orthopedic surgical procedures which can restore hip function and improve the patient's quality of life. However, total hip arthroplasty is significantly associated with postoperative pain. Pain after total hip arthroplasty surgery can adversely affect the patient's early postoperative recovery, postoperative mobility, and hinder rehabilitation.
Wrist ankle acupuncture (WAA) is a simpler acupuncture technique, using fewer points, shallow needle insertion and lighter stimulation. Wrist-ankle acupuncture as multimodal analgesia after orthopedic surgery is useful for reducing pain and reduce the incidence of post-surgical side effects. The primary aim of this study is to investigate whether wrist ankle acupuncture therapy gives better and results for post total hip arthroplasty pain than sham wrist ankle acupuncture conditions: Pain, Postoperative conditions: Hip Osteoarthritis conditions: Hip Fractures conditions: Hip Injuries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 32 type: ESTIMATED name: wrist ankle acupuncture measure: Visual Analog Scale measure: recovery rate sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Cipto Mangunkusumo Hospital status: RECRUITING city: Jakarta Pusat state: Jakarta zip: 10430 country: Indonesia name: Cipto Mangunkusumo Hospital role: CONTACT phone: 1 500 135 lat: -6.1818 lon: 106.8223 facility: Fatmawati Hospital status: RECRUITING city: Jakarta zip: 12430 country: Indonesia name: Fatmawati Hospital role: CONTACT phone: 0217501524 lat: -6.21462 lon: 106.84513 facility: Persahabatan Hospital status: RECRUITING city: Jakarta zip: 13230 country: Indonesia name: Persahabatan Hospital role: CONTACT phone: (021) 4891708 lat: -6.21462 lon: 106.84513 hasResults: False
nctId: NCT06380426 id: APHP230441 id: IDRCB : 2023-A02003-42 type: OTHER domain: ANSM briefTitle: Real-life Evaluation of WEGOVY (Semaglutide) Treatment in Adults With Monogenic Obesity (ObGeSema) acronym: ObGeSema overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2027-04-30 date: 2027-11-30 date: 2024-04-23 date: 2024-04-23 name: Assistance Publique - Hôpitaux de Paris class: OTHER briefSummary: Rare genetic forms of obesity, so called monogenic obesity are linked to alteration in energy balance involving hypothalamic pathways.
The hypothesis in this study is that treatment with Semaglutide 2.4mg/week (WEGOVY®) could be as effective in monogenic obesities as in common obesity. conditions: Monogenic Obesity studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 175 type: ESTIMATED measure: Change in weight and Body Mass Index (BMI) measure: Change in weight and Body Mass Index (BMI) measure: Reduction of body weight equal to or above 5% measure: Change in Hunger score measure: Change in eating behaviour measured by Food Craving questionnaire measure: Change in eating behaviour measured by the Binge Eating Scale (BES) measure: Change in eating behaviour measured by the Dutch Eating Behaviour Questionnaire (DEBQ) measure: Change in eating behaviour measured by the Dykens questionnaire measure: Change in eating behaviour measured by the Child Eating Behaviour Questionnaire (CEBQ) measure: Change in the International physical activity questionnaire (IPAQ - short form) measure: Change in Digestive disorders (GIQLI ) measure: Change in sleep disorder (MCTQ score) measure: Change in score of quality of life scores (patient and parents) measure: Change in anxiety and depression score measure: Treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre de référence Syndrome de Prader-Willi et autres obésités avec troubles du comportement alimentaire (PRADORT). Service de Nutrition, GH Pitié-Salpêtrière, APHP city: Paris zip: 75013 country: France name: Emilie GUILLON role: CONTACT email: emilie.guillon-ext@aphp.fr name: Sarra POCHON role: CONTACT phone: +33(1)42167574 email: sarra.pochon@aphp.fr lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06380413 id: 78972024.7.0000.5313 briefTitle: Tai Chi Chuan Combined With Walking on Physical and Mental Parameters of Older Adults overallStatus: NOT_YET_RECRUITING date: 2024-05-20 date: 2024-12-31 date: 2025-07-31 date: 2024-04-23 date: 2024-04-23 name: Federal University of Pelotas class: OTHER briefSummary: Background: Tai Chi Chuan, a Chinese martial art style, is a mind-body modality that has shown positive impacts on health markers in various populations, particularly older adults. This study aims to investigate the effects of a 12-week program of Tai Chi Chuan exercises based on the Yang 16-movement form and walking on older adults' physical and mental markers.
Methods: This study is a randomized, single-blinded, two-arm, parallel, superiority trial. Forty older adults between 60 and 75 years old who are not engaged in any systematic strength and aerobic training program will be recruited. Candidates with language and cognitive problems, a history of cardiovascular diseases (except controlled hypertension), osteoarticular limitations and fractures, severe injuries, and prosthetic placement in the last six months will be excluded. Participants will be randomly allocated on a 1:1 ratio to a 12-week intervention with Tai Chi Chuan and walking two times per week, or an active-control group with walking two times per week. Physical measures will be muscle strength (i.e., knee extensors maximum strength and lower limbs functional performance -primary outcomes-, dynamic knee extensors endurance, handgrip strength, back-leg-chest strength), functional capacity, static balance, muscle thickness and muscle quality of quadriceps. Mental measures will be quality of life, sleep quality, cognitive function, and depressive and anxiety symptoms. Outcomes will be measured before and after 12 weeks of intervention. The analysis plan will use an intention-to-treat approach and protocol criteria.
Discussion: The conceptual hypothesis is that the intervention training program with Tai Chi Chuan and walking will lead to greater improvements in both physical and mental parameters due to its multi-component character compared to the walking active-control group. conditions: Aging studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This study is a randomized, single-blinded, two-arm, parallel, superiority trial. Forty healthy and physically inactive subjects, 60 to 75 years of age, are recruited. Participants are randomly allocated on a 1:1 ratio to a 12-week intervention of Tai Chi Chuan plus walking program twice a week, or an active-control group of walking twice a week. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Blinding will be implemented for the outcome assessors. All tests and questionnaires will be supervised by an evaluator blinded to the participant's group. Due to the type of intervention, the investigator conducting exercise sessions and participants will not be blinded. whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: Tai Chi Chuan Plus Walking name: Walking measure: Maximal dynamic strength measure: Functional test - 30-s Chair-stand test measure: Dynamic muscular endurance measure: Isometric handgrip strength measure: Isometric back-leg-chest strength measure: Functional tests - arm curl measure: Functional tests - 8-ft Up-and-Go measure: Functional tests - Chair Sit-and-Reach measure: Functional tests - Back Scratch measure: Funcional tests - 6-min Walk measure: Static balance - 30-second single-leg stance test measure: Quadriceps muscle thickness measure: Quadriceps muscle quality measure: Objective cognitive function - Trail Making Test (TMT) measure: Objective cognitive function - Controlled Oral Word Association Test (COWAT) measure: Quality of Life - Abbreviated World Health Organization Quality of Life (WHOQOL-Bref) measure: Sleep quality - Pittsburgh Sleep Quality Index measure: Depressive and anxiety symptoms is measured using the Hospital Anxiety and Depression Scale (HADS) measure: Body mass measure: Height measure: Waist and hip circumferences measure: Monitoring the intensity of training sessions - Borg Category-Ratio 10 (CR-10) measure: Follow-up questionnaire measure: Adherence assessments measure: Health Questionnaire measure: Level of physical activity - International Physical Activity Questionnaire (IPAQ) - extended version measure: Cognitive screening - Mini-mental state examination (MMSE) sex: ALL minimumAge: 60 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Escola Superior de Educação Física e FIsioterapia city: Pelotas state: Rio Grande Do Sul zip: 96055630 country: Brazil name: Cristine L Alberton, PhD role: CONTACT lat: -31.77194 lon: -52.3425 hasResults: False
nctId: NCT06380400 id: 0000-0001-5786-4385 briefTitle: The Effect of Foot Bath on Birth Pain and Birth Comfort overallStatus: RECRUITING date: 2024-02-01 date: 2024-07-30 date: 2024-07-30 date: 2024-04-23 date: 2024-04-23 name: Selcuk University class: OTHER briefSummary: Although childbirth is seen as a natural, happy, meaningful and universal experience, women are often faced with severe pain, discomfort and a sensory state that can be overwhelming. There are two ways to reduce labour pain: pharmacological (drugs) and non-pharmacological (non-drug methods). Non-pharmacological methods, in particular, attempt to relieve pain by addressing emotional, cognitive, behavioural and socio-cultural dimensions. These methods provide relief and reduce the perception of pain. One of the non-pharmacological methods used to reduce labour pain is footbaths. Footbaths are widely used as a nurse/midwife intervention in many countries. Footbathing is a simple technique used to induce a sense of comfort and relaxation. It involves gently immersing the patient's legs and feet (below the knees) in a basin of warm water. Local heat treatments are generally safe and are considered an effective form of complementary medicine. In its simplest form it means "a tool to be part of supportive care, promoting peace, positive emotions, comfort, satisfaction and enjoyment". The mechanisms responsible for the effects of footbathing are not fully understood, but soaking the feet in warm water and stimulating the sense of touch through massage or washing can reduce sympathetic nerve activity, thereby reducing pain and increasing comfort. In other words, reducing pain during labour means providing support and comfort to the woman. This study was designed to evaluate the effect of a foot bath applied in the first stage of labour on labour pain and comfort in nulliparous women. conditions: Parturition studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: PARTICIPANT count: 196 type: ESTIMATED name: Foot bath measure: Visuell analog scale score of the pregnant woman measure: Birth comfort scale score of the pregnant woman sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Habibe Bay Ozcalik status: RECRUITING city: Konya zip: 42250 country: Turkey name: Habibe Bay Ozcalik role: CONTACT phone: 05424469343 email: habiberk@hotmail.com lat: 37.87135 lon: 32.48464 hasResults: False
nctId: NCT06380387 id: H-21046543 briefTitle: Whole Body Metabolism in Children Before and After Treatment of CNS Tumor overallStatus: RECRUITING date: 2023-03-23 date: 2025-12 date: 2026-12 date: 2024-04-23 date: 2024-04-23 name: Rigshospitalet, Denmark class: OTHER briefSummary: At the center of pediatric oncology in Copenhagen the investigators experience that the children with brain tumor, more or less have a healthy body with normal skeletal muscle mass and are physical active to the same level as their friends at the same age. The treatment period for brain tumor is approximately two years. After the treatment period, the children are more sedative with less interest in coming out doing physical activities and thus the investigators suspect that they have altered hormonal response, low skeletal muscle mass and perhaps are in risk of developing metabolic syndrome.
The investigators aim to include 10 children (aged 6-18 years) with newly diagnosed CNS tumor, 10 children (aged 6-18 years) finished treated for CNS tumor and 10 healthy controls (aged 6-18 years). By using stable isotope technique the investigators will investigate systemic fat, glucose and protein metabolism together with liver protein degradation and glucose production. Furthermore, by using DXA scan the investigators will describe the quality and distribution of skeletal muscle. Lastly, the investigators will determine the skeletal muscle signal pathway and metabolism in skeletal muscle via the Bergström biopsy technique in vastus lateralis. conditions: CNS Tumor, Childhood studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 30 type: ESTIMATED name: Meal measure: Protein breakdown measure: Protein synthesis measure: Phenylalanine concentration measure: Phe oxidation to TYR measure: Whole-body protein synthesis measure: Whole-body protein degradation measure: Netto protein balance measure: Glucose Rate of appearance measure: Total glucose Rate of appearance measure: Total glucose Rate of disappearance measure: Endogenous glucose measure: Oral phenylalanine Rate of appearance measure: Phenylalanine oxidation measure: Rate of Appearance of Palmitate in Plasma measure: Rate of Disappearance of Palmitate measure: Concentration of ketones measure: Glucose measure: Quality of Skeletal Muscle measure: Protein synthesis rate measure: Pain score measure: Life quality score measure: Muscle biopsy measure: Incretins measure: Glucagon measure: Liver parameters ALT, AST, GGT measure: Bilirubin measure: International normalized ratio (INR) measure: LDH measure: Insulin measure: catecholamines measure: Blood pressure measure: Waist- and hip circumference measure: Lipids measure: Concentration of Plasma Amino Acids measure: Concentration of Plasma Glucose measure: Concentration of Plasma Palmitate measure: Concentration of Plasma Free Fatty Acids measure: Level of HbA1c sex: ALL minimumAge: 6 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Department of Pediatrics and Adolescent Medicine and Copenhagen Neuromuscular Center, Rigshospitalet status: RECRUITING city: Copenhagen state: Copenhagen Ø zip: 2100 country: Denmark name: Mette Cathrine Ørngreen, MD, DMSc role: CONTACT phone: 35455935 email: mette.cathrine.oerngreen.01@regionh.dk name: Mette Cathrine Ørngreen, MD, DMSc role: PRINCIPAL_INVESTIGATOR lat: 55.67594 lon: 12.56553 hasResults: False
nctId: NCT06380374 id: 2024\01 briefTitle: Gamification in Disaster Nursing Education overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2024-07-01 date: 2024-07-22 date: 2024-04-23 date: 2024-04-23 name: Selcuk University class: OTHER briefSummary: This research will be conducted as a randomized controlled study with a parallel design to evaluate the effectiveness of the disaster nursing training program prepared with a gamification strategy based on multiple intelligence theory for final-year public health nursing students. Research hypothesis "H1a: The disaster nursing knowledge level of the students participating in the program, which is prepared with a Gamification Strategy Based on Multiple Intelligence Theory, differs from the control group. H1b: The perception of volunteering towards disaster nursing differs for the students included in the Program Prepared with Gamification Strategy Based on Multiple Intelligence Theory compared to the control group. H1c: The self-efficacy level of students involved in the Program Prepared with Gamification Strategy Based on Multiple Intelligences Theory regarding disaster nursing differs from the control group." conditions: Gamification conditions: Nursing Students conditions: Multiple Intelligence Theory conditions: Disaster Nursing studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE whoMasked: PARTICIPANT count: 72 type: ESTIMATED name: Gamification in Disaster Nursing Education measure: Level of knowledge related to disaster nursing services measure: Volunteer intention to become a disaster nurse measure: Perception of self-efficacy related to disaster nursing sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Selcuk University Faculty of Nursing city: Konya state: Selcuklu zip: 42000 country: Turkey name: Sema Yilmaz Dean, MD role: CONTACT phone: +903322230763 email: hemsirelikfakultesi@selcuk.edu.tr lat: 37.87135 lon: 32.48464 hasResults: False
nctId: NCT06380361 id: SEN-ONCO-1 briefTitle: InvestigatioN of a Smart Probe for Lung lEsion Characterization Using Impedance Technology acronym: INSPECT overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2025-03-31 date: 2025-04-01 date: 2024-04-23 date: 2024-04-23 name: Sensome class: INDUSTRY briefSummary: The objective of the study is to evaluate the feasibility of the BioSpy System sensor to differentiate tissues that are encountered during bronchoscopic biopsy of endobronchial tumors and peripheral lung nodules and masses. conditions: Lung Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Patient with suspected lung cancer coming to the hospital for bronchoscopic biopsy will be selected for this trial. primaryPurpose: OTHER masking: NONE maskingDescription: No masking count: 30 type: ESTIMATED name: BioSpy System measure: The ability of BioSpy System to acquire electrophysiological measurements in the relevant tissues during bronchoscopic biopsy. measure: The ability of BioSpy Sysem to differentiate the lesion from healthy tissue measure: The ability of BioSpy Sysem to differentiate various lesion types sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06380348 id: JMT101-012 briefTitle: JMT101 in Combination With Osimertinib, Versus Cisplatin-pemetrexed in Participants With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Characterized by Epithermal Growth Factor Receptor (EGFR) Exon 20ins Mutations overallStatus: NOT_YET_RECRUITING date: 2024-04-26 date: 2027-03-26 date: 2028-03-26 date: 2024-04-23 date: 2024-04-23 name: Shanghai JMT-Bio Inc. class: INDUSTRY briefSummary: This is a multicenter, randomized, open-label, parallel-controlled phase 3 study. This study aims to evaluate the efficacy and safety of JMT101 combined with Osimertinib compared with Cisplatin combined with pemetrexed in participants with local advanced or metastatic non-small-cell lung cancer harboured EGFR 20ins mutation without prior systemic therapy.