hackint0sh/New-Dataset huggingface dataset:
METHOD: This would be a hospital based randomized controlled trial comparing intravenous paracetamol to intramuscular tramadol as labour analgesia in pregnant women in active phase of labour in the department of obstetrics and gynecology at Alex-Ekwueme Federal University Teaching Hospital and St. Patrick Mile 4 hospital, Abakaliki. A total of 194 pregnant women in active phase of labour will be included in study after fulfilling the inclusion criteria. These women will be divided into 2 groups of 97 each. Group A will receive a 100ml intravenous infusion containing 1000mg of paracetamol single dose over 15min. Group B: will receive intramuscular tramadol hydrochloride 100mg single dose. Pain intensity of women with both drugs will be noted before administration of drug, one hour, two hours and three hours after administration of drug using the visual analog scale. Perinatal outcome will also be recorded.
10 ANALYSIS AND RESULTS: Data will be collated, tabulated and then statistically analyzed using Statistical Package for Social Science (IBM SPSS) software (version 24, Chicago II, USA). Continuous variables will be presented as mean and standard deviation (Mean ± 2SD) or median and range as appropriate, while categorical variables will be presented as frequencies and percentages. Chi-square test( or Fisher's exact test where applicable) will be used for comparison between groups for categorical variables while student t test or Mann-Whitney U test will be used for comparison between groups for continuous variables KEYWORDS Labour analgesia, intravenous paracetamol, intramuscular tramadol, visual analog scale, neonate, side effects. conditions: Pain studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: To compare intravenous paracetamol versus intramuscular tramadol as labour analgesia and to evaluate the incidence of side effects on mother and baby of both drugs primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Double blinded whoMasked: PARTICIPANT count: 194 type: ACTUAL name: Paracetamol measure: Mean pain score sex: FEMALE minimumAge: 15 Years maximumAge: 45 Years stdAges: CHILD stdAges: ADULT facility: AEFUTHA city: Abakaliki state: Ebonyi zip: 234 country: Nigeria lat: 6.32485 lon: 8.11368 hasResults: False
nctId: NCT06371118 id: PI 20210032 briefTitle: HPV Self-sampling for Women Who do Not Attend Cervical Cancer Screening Programme acronym: HERSELF overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-09 date: 2024-11 date: 2024-04-17 date: 2024-04-17 name: Universidade do Porto class: OTHER name: Unidade de Saúde Familiar de Garcia de Orta, Porto name: Unidade de Saúde Familiar da Prelada, Porto name: Unidade de Saúde Familiar de Cedofeita, Porto name: Instituto Portugues de Oncologia, Francisco Gentil, Porto briefSummary: This study aims to test the effectiveness and cost-effectiveness of two different strategies of home-delivered HPV self-sampling, in comparison to the standard of care strategy, to increase adherence to cervical cancer screening.
An experimental and population-based study will be implemented at three primary healthcare centers located in the Western Porto region: Cedofeita, Garcia de Orta, and Prelada. Eligible women will be randomized into a control group or an intervention group. The control group will correspond to the standard of care (invitation to screening in a clinical setting). The intervention group will be randomized into two subgroups: 1) a "directly mailed" group that will receive a self-sampling kit at their home addresses by post; 2) an "opt-in" group that will receive an invitation at home asking if they want to receive a self-sampling kit, with a pre-paid envelope to return the answer to this question. Women who answer "yes" will receive the self-sampling kit at their home addresses by post.
nctId: NCT06371105 id: 014_2018 briefTitle: Aquatic_Training in Obese Women overallStatus: COMPLETED date: 2019-01-02 date: 2019-03-30 date: 2019-03-30 date: 2024-04-17 date: 2024-04-17 name: University of Taipei class: OTHER briefSummary: This study aims to assess the effects of 10-week water-based aerobic training (thrice a week) on anthropometrics, biochemicals, cardiovascular parameters, and explosive strength in young overweight and obese women. The findings indicate that water-based aerobic training could be a useful program to enhance body composition, biochemical, cardiovascular, and explosive strength parameters in young overweight and obese women compared to inactive persons conditions: Obesity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE whoMasked: PARTICIPANT count: 31 type: ACTUAL name: 10-week water-based aerobic training measure: fasting glycemia in millimoles per liter measure: total cholesterol in millimoles per liter measure: high-density lipoprotein cholesterol in millimoles per liter measure: low-density lipoprotein cholesterol in millimoles per liter measure: triglyceride concentrations in millimoles per liter measure: systolic blood pressure in millimeters of mercury measure: diastolic blood pressure in millimeters of mercury measure: heart rate in beat per minute measure: fasting glycemia in millimoles per liter measure: total cholesterol in millimoles per liter measure: high-density lipoprotein cholesterol in millimoles per liter measure: low-density lipoprotein cholesterol in millimoles per liter measure: triglyceride concentrations in millimoles per liter measure: systolic blood pressure in millimeters of mercury measure: diastolic blood pressure in millimeters of mercury measure: heart rate in beat per minute measure: countermovement jump in centimetres measure: squat jump in centimeters measure: chest 3-kg medicine ball throw in meters measure: countermovement jump in centimetres measure: squat jump in centimeters measure: chest 3-kg medicine ball throw in meters sex: FEMALE minimumAge: 29 Years maximumAge: 35 Years stdAges: ADULT facility: Department of Exercise and Health Sciences, University of Taipei city: Taipei zip: 11153 country: Taiwan lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06371092 id: 2023/01 briefTitle: Efficacy of a Desensitizing Agent During At-home Bleaching overallStatus: COMPLETED date: 2023-01-31 date: 2023-02-22 date: 2023-03-01 date: 2024-04-17 date: 2024-04-17 name: University of Santiago de Compostela class: OTHER briefSummary: The main objective of this study is to evaluate if the use of UltraEZ during at-home bleaching treatment is effective in reducing tooth sensitivity, as well as doesn't affect the degree of tooth bleaching. conditions: Sensitivity, Tooth studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized, triple-blind clinical trial primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 32 type: ACTUAL name: UltraEZ name: Placebo measure: Questionnaire of dental sensitivity measure: Shade evaluation with a dental spectrophotometer sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: School of Medicine and Dentistry city: Santiago De Compostela state: A Coruña zip: 15705 country: Spain lat: 42.88052 lon: -8.54569 hasResults: False
nctId: NCT06371079 id: NO-OVD-ICL briefTitle: Safety and Suitability of ICL for Correction of Refractive Errors Without the Use of Dispersive OVDs overallStatus: RECRUITING date: 2024-03-01 date: 2024-05-30 date: 2024-06 date: 2024-04-17 date: 2024-04-17 name: Loay Abdulmutalib Almusawi class: OTHER briefSummary: The goal of this observational study is to test whether surgeries for lenses designed to be implanted in the eye to correct refractive error can be done without the need for using viscoelastic substances that are used routinely nowadays to make it easier to introduce them inside the human eye and protect the inside of the eye during the operation.
The main question it aims to answer is that is it safe to do the surgery without using them? to answer this question researchers will access recorded data of patients that underwent refractive surgeries in a private clinic since 2017 and compare them as two groups: those who underwent the traditional procedures and those who had it without the use of dispersive viscoelastics in regard to their vision before and after surgery, their ocular pressure and biomicroscopic analysis of the inside of their corneas before and after surgery. conditions: Refractive Errors conditions: Myopia conditions: Myopic Astigmatism conditions: Hypermetropia studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 400 type: ESTIMATED name: phakic intraocular lens implantation traditional name: phakic intraocular lens implantation reduced OVD measure: unaided visual acuity after the procedure measure: best corrected visual acuity after the procedure measure: Intraocular pressure postoperatively measure: Specular microscopy parameter: endothelial cell density measure: Specular microscopy parameter: endothelial cells hexagonality measure: Specular microscopy parameter: coefficient of variation of corneal endothelial cells measure: postoperative complications sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Al-Ferdows private eye hospital status: RECRUITING city: Baghdad country: Iraq name: Sohaib A Mahmood, CABMS role: CONTACT phone: 00971585358111 email: sohaib.mahmood@meciq.edu.iq name: Sami A Hasoon role: CONTACT phone: +9647901867279 email: Ferdouseyeshospital@yahoo.com name: Sohaib A Mahmood, CABMS role: PRINCIPAL_INVESTIGATOR name: Loay A Almusawi, FIBMS role: SUB_INVESTIGATOR name: Hamid M Altaha, CABMS role: SUB_INVESTIGATOR name: Bashar Alwash, CABMS role: SUB_INVESTIGATOR lat: 33.34058 lon: 44.40088 hasResults: False
nctId: NCT06371066 id: EAkyuz-2 briefTitle: The Effect of Video-based Training on the Knowledge Levels of Nursing Students overallStatus: COMPLETED date: 2021-02-01 date: 2021-04-01 date: 2021-06-10 date: 2024-04-17 date: 2024-04-17 name: Kırıkkale University class: OTHER briefSummary: Although face-to-face education is widely used as a traditional method, emerging computer technology has allowed new training approaches such as video-based training (VBT) platforms to flourish, especially in the last four decades. Educators adopted VBT as a cost-effective and accessible medium to address some of their training needs. It contains purposely designed visual cues and draws learners' attention during the learning process, and the dynamic details enable learners to better understand the learning contents. The use of new technologies such as e-learning, computer-assisted learning, VBT, and web-based applications for clinical skill education has increased learner satisfaction compared with conventional education methods. Preoperative patient preparation is a crucial element of preoperative nursing care. A surgical nurse is a specialized coordinator of patient care, and the main purposes of this role are to meet the patient's and the family's needs individually and to prepare them for the scheduled procedure and postoperative recovery. Preoperative patient preparation contains multiple components and steps such as preoperative education, including physical, social, psychological, and legal preparation, and preparation for the night and day of surgery. the nature of the process has many components and steps, it is not easy for students to learn this subject, and nursing educators were able to experience this in a clinical practice environment. And the educators started to search for new teaching techniques to teach this subject like the other colleagues. the investigator's aim in this project is to determine the effect of VBT on the knowledge levels of nursing students on preoperative patient preparation when compared to traditional training methods. conditions: Student Nursing conditions: Medical-surgical Nursing conditions: Nursing Care conditions: Education studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: intervention, control primaryPurpose: OTHER masking: SINGLE maskingDescription: it was an educational intervention. All participants were in the same class so we blinded only statisticians. whoMasked: OUTCOMES_ASSESSOR count: 97 type: ACTUAL name: experimental group name: Control group measure: The Student Information Form measure: The Knowledge Form for Preoperative Patient Preparation sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kirikkale University city: Kirikkale country: Turkey lat: 39.84528 lon: 33.50639 hasResults: False
nctId: NCT06371053 id: community - dementia briefTitle: The Effect of Community Intervention on Different Degrees of Dementia overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-05 date: 2024-05 date: 2024-04-17 date: 2024-04-17 name: Babujinaya Cela class: OTHER_GOV briefSummary: The goal of this clinical trial is to explore the impact of Community Intervention on Dementia and Activities of Daily Living in community-dwelling elderly individuals (≥60 year old) with Alzheimer's disease. It primarily aims to address: the effects of Community Intervention on Dementia and Activities of Daily Living in community-dwelling elderly individuals with Alzheimer's disease in different degrees. All participants are required to undergo a continuous 2-week (14 days) Community Intervention, with weekends off and training conducted only on weekdays. The training will be conducted two sessions per day, lasting 30 minutes each. conditions: Alzheimer Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 200 type: ESTIMATED name: Community Intervention measure: Mini-Mental State Examination measure: Barthel Index measure: Functional near-infrared spectroscopy sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06371040 id: V1.0, CART-20230619 briefTitle: Safety and Efficacy of CD19-BCMA Targeted CAR-T Therapy for Refractory Generalized Myasthenia Gravis overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-03-01 date: 2026-12-01 date: 2024-04-17 date: 2024-04-17 name: Ting Chang, MD class: OTHER briefSummary: This study is a single-center, open-label, single-arm, dose-exploration study to evaluate the safety and preliminary effectiveness of CD19-BCMA CAR-T in the treatment of refractory, generalized myasthenia gravis. The study is a dose escalation trial in adult, refractory, systemic MG patients. The Keyboard method will be used to perform dose escalation to explore the maximum tolerated dose (MTD). A total of 12 MG patients who meet the inclusion criteria are expected to be recruited. conditions: Myasthenia Gravis studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SEQUENTIAL interventionModelDescription: CD19-BCMA Targeted CAR-T Dose 1 5.0 e5/ kg CD19-BCMA CAR-T positive T cells
CD19-BCMA Targeted CAR-T Dose 2 5 e6/ kg CD19-BCMA CAR-T positive T cells primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: CD19-BCMA Targeted CAR-T Dose 1 name: CD19-BCMA Targeted CAR-T Dose 2 name: CD19-BCMA Targeted CAR-T Dose 2 measure: Frequency, type, and severity of adverse events measure: Frequency, type, and severity of abnormal laboratory indicators related to treatment measure: Changes of blood pressure measure: Changes of pulse rate measure: Changes of weight measure: Changes of Myasthenia Gravis Activities of Daily Living (MG-ADL) scores measure: Changes of Quantitative Myasthenia Gravis (QMG) scores measure: Changes of Myasthenia Gravis Composite (MGC) scores measure: Proportion of subjects who achieved improvement measure: Time to achieve clinical improvement measure: Changes of myasthenia gravis-specific autoantibody titers measure: Changes of immunoglobulins measure: Changes in proportion of peripheral blood immune cell measure: serum inflammatory markers levels sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tangdu Hospital, The Fourth Military Medical University city: Xi'an state: Shaanxi zip: 710038 country: China lat: 34.25833 lon: 108.92861 hasResults: False
nctId: NCT06371027 id: RECO6U/22-2022 briefTitle: Novel Silk Fibroin Nanofiber Membrane Using Minimally Invasive Surgery in Treatment of Periodontal Intrabony Defects: A Randomized Clinical Trial overallStatus: COMPLETED date: 2022-11-01 date: 2024-02-15 date: 2024-04-01 date: 2024-04-17 date: 2024-04-17 name: October 6 University class: OTHER briefSummary: Clinically and radiographically by cone beam CT evaluate the regenerative potentials of silk fibroin (SF) nanofiber membrane, using minimally invasive surgery, for the regenerative treatment of intrabony periodontal defects. conditions: Intrabony Periodontal Defect studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 30 type: ACTUAL name: Minimally Invasive Surgery Technique (MIST) + Novel Silk Fibroin (SF) nanofiber membrane name: Minimally Invasive Surgery Technique (MIST) + collagen membrane name: Minimally Invasive Surgery Technique (MIST) measure: Novel Silk Fibroin Nanofiber Membrane using minimally invasive surgery in Treatment of Periodontal Intrabony Defects sex: ALL minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT facility: faculty of dentistry O6U city: Giza country: Egypt lat: 30.00808 lon: 31.21093 hasResults: False
nctId: NCT06371014 id: Ondansetron mouth soluble film briefTitle: Comparative Study on the Efficacy and Safety of Ondansetron Oral Membrane for the Prevention of Vomiting During Moderate Hypoemetic Chemotherapy acronym: Ondansetron overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-30 date: 2024-12-31 date: 2024-04-17 date: 2024-04-17 name: Shanghai Children's Medical Center class: OTHER briefSummary: Children aged 4-15 years scheduled to receive Moderate or low emetic chemotherapy were randomly assigned to arm-A (Ondansetron mouth soluble film) or arm-B (Ondansetron tablet). Children recruited to arm-A received ondansetron mouth soluble film plus dexamethasone. Children recruited to arm-B received Ondansetron tablet plus dexamethasone. Ondansetron and dexamethasone were given continuously until 48hours after completion of chemotherapy. The primary end point of the study was to determine the proportion of patients who achieved a CR, defined as no vomiting, no retching, and no use of rescue medication, the proportion of patients who achieved a CR during the acute phase (0-24 hours) after administration of the last dose of chemotherapy. Secondary end points were the proportion of patients who achieved a CR during the 24-120 hours (delayed phase) and overall after administration of the last dose of chemotherapy conditions: To Analyze and Compare the Efficacy and Safety of Ondansetron and Tablet for the Prevention of Moderate and Hypoemetic Chemotherapy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 200 type: ESTIMATED name: Ondansetron oral membrane measure: Complete Remission Rates in the Acute Phases measure: Complete Remission Rates in the Delayed Phases sex: ALL minimumAge: 4 Years maximumAge: 15 Years stdAges: CHILD hasResults: False
nctId: NCT06371001 id: Helicobacter Pyloi and CKD briefTitle: Prevalance Of Helicobacter Pylori Infection In Chonic Kidney Diseased Patient Admitted To Luxor Medical Complex overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-07-01 date: 2024-04-17 date: 2024-04-17 name: Assiut University class: OTHER briefSummary: Detect prevalence of Helicobacter pylori infection in chronic kidney diseased patient admitted to Luxor medical complex and possible role of Helicobacter pylori in pathogenesis of chronic kidney diseased patient of unknown etiology conditions: Chronic Kidney Diseases studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 122 type: ESTIMATED name: disease measure: Helicobacter pylori infection and Chronic kidney diseased patient measure: possible role of H pylori in pathogenesis of chronic kidney diseased patient of unkown etiology sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06370975 id: Fluid resuscitation in trauma briefTitle: Effect of Fluid Resuscitation on Lactate in Traumatic Injury Patients overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2025-08 date: 2025-09 date: 2024-04-17 date: 2024-04-17 name: Assiut University class: OTHER briefSummary: The study aims to investigate the effect of 3% hypertonic saline resuscitation on lactate clearance in comparison to ringer's lactated solution and 0.9% normal saline in traumatic injury patients.
Also to provide insights into the optimal fluid resuscitation strategy for traumatic injury patients conditions: Fluid Resuscitation studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 150 type: ESTIMATED name: 3% hypertonic Saline name: Ringer's lactated solution name: 0.9% Normal saline measure: Rate of lactate clearance following resuscitation with different solutions sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06370962 id: 69HCL24_0076 id: 2024-A00343-44 type: OTHER domain: ID-RCB briefTitle: Circadian Rhythm Disorders in Children With Cystic Fibrosis Under CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Modulators acronym: CHRONO-MUCO overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-11 date: 2026-01 date: 2024-04-17 date: 2024-04-17 name: Hospices Civils de Lyon class: OTHER briefSummary: Cystic fibrosis (CF) is a rare disease affecting one out of 4,500 newborns in France (INSERM 2021). Despite major advances in patient care over the past two decades, with significant improvements in life expectancy, cystic fibrosis remains a pathology that considerably impairs quality of life.
The existence of chronotype abnormalities has been suggested in CF patients, but no precise data are available (Louis 2022). The involvement of CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) protein dysfunction in the central nervous system (CNS) has been hypothesized as a contributory factor. In vivo, in a mouse model of CF, dysregulation of clock genes such as Clock, Cry2 and Per2 was found in the CNS (Barbato 2019). Among them, certain genes such as Rev-erbα could regulate endobronchial inflammation and contribute to the severity of respiratory pathology. All in all, chronotype abnormalities could be at the origin of sleep debt, impaired cognitive functions or metabolic disturbances.
In the era of highly effective modulator therapy (HEMT) for the treatment of CF, the impact of these new therapies on chronotype has been understudied. Assuming that chronotype abnormalities are a direct consequence of CFTR protein dysfunction in the retina and anterior hypothalamus, HEMT should improve sleep quality. However, between 20% and 30% of adult and pediatric patients express an increase in chronotype abnormalities following initiation of treatment.