hackint0sh/New-Dataset huggingface dataset:
Patients will be divided into two groups based on whether they have a more than 25% decrease in estimated glomerular filtration rate (t-GFH) and/or a 1.5-fold increase in serum creatinine and/or a 6-hour urine volume of less than 0.5 ml/kg/h. The patients will be divided into two groups based on this definition, and the risk factors between these groups will be analysed.
The preoperative routine blood values, demographic data (age, gender, height, weight, and BMI), ASA physical status, smoking and alcohol habits, comorbidities, and regular medication use will be recorded. Intraoperative urine output and haemodynamic parameters will also be monitored. Routine blood gas analysis, blood urea nitrogen (BUN), glomerular filtration rate (GFR), albumin, haemoglobin, sodium, potassium, chlorine, and magnesium will be measured and recorded, along with urine output and t-GFH. Patients will be evaluated in the hospital on the day the surgeon calls for a postoperative check-up and on the 30th postoperative day to see if there are any complications. conditions: Acute Kidney Injury conditions: Surgery conditions: Lung Cancer studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Duration of Surgery name: Volume of Fluid in Surgery name: Blood Loss measure: Glomerular Filtration Rate measure: Serum Creatinine measure: Amount of Urine sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ankara Atatürk Sanatorium Training and Research Hospital city: Ankara state: Keçiören zip: 06290 country: Turkey name: Ali ALAGÖZ, professor role: CONTACT phone: 5079193765 phoneExt: +9 email: mdalagoz@gmail.com name: Fatma ÖZTÜRK YALÇIN, specialist role: SUB_INVESTIGATOR name: Onur KÜÇÜK, specialist role: SUB_INVESTIGATOR lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06341920 id: RS198 - 332551 briefTitle: BoneFit: Multimodal Prehabilitation for People Preparing for Orthopaedic Surgery acronym: BoneFit overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-07-01 date: 2027-12-01 date: 2024-04-02 date: 2024-04-02 name: University of Hull class: OTHER name: Hull University Teaching Hospitals NHS Trust briefSummary: To conduct a pilot feasibility study to determine the effect of a student-led prehabilitation service in people awaiting total hip or knee replacement surgery. conditions: Orthopedic Disorder studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Intervention v control primaryPurpose: TREATMENT masking: NONE maskingDescription: Masking is not possible - referrals/care providers know whether they/referral is involved in the intervention or not. count: 50 type: ESTIMATED name: Experimental: BoneFit intervention name: Placebo Comparator: Control measure: Recruitment measure: Adherence and attendance measure: Acceptability measure: Physical fitness measure: Length of stay measure: Readmission rates measure: Overall quality of life measure: Knee or hip specific pain, function and quality of life sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2024-02-13 uploadDate: 2024-03-12T06:12 filename: Prot_000.pdf size: 218343 hasResults: False
nctId: NCT06341907 id: SAHoWMU-CR2024-07-107 briefTitle: Application of MRD Combined With Personalized Vaccine in the Treatment of Postoperative Recurrence Prevention of EOC overallStatus: RECRUITING date: 2024-01-01 date: 2026-12-31 date: 2026-12-31 date: 2024-04-02 date: 2024-04-02 name: Second Affiliated Hospital of Wenzhou Medical University class: OTHER briefSummary: The goal of this clinical trial is as follows:(1) Establish a clinical technical system for ctDNA dynamic monitoring of MRD in postoperative EOC patients, providing a new technical means for postoperative recurrence prevention and monitoring of EOC patients.(2) Establish a clinical technical system for adjuvant treatment of postoperative recurrence prevention for EOC patients with conventional protocols combined with personalized vaccines, so as to provide a new treatment method for postoperative recurrence prevention for EOC patients, with a view to obtaining a better survival prognosis.(3) To establish and improve the prediction process of Neoantigen for ovarian cancer and the in vitro evaluation system of the effectiveness of neoantigen vaccine, achieve independent innovation of tumor neoantigen vaccine treatment technology, and cultivate a group of technical forces to master the development of modern tumor vaccine drugs.(4) The new technology system has been promoted and applied in 5 hospitals in the province. conditions: Epithelial Ovarian Cancer studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: Neoantigen polypeptide vaccine measure: ORR measure: PFS measure: OS measure: CA 125 measure: Safety Index sex: FEMALE minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Second Affiliated Hospital of Wenzhou Medical University status: RECRUITING city: Wenzhou state: Zhejiang zip: 325000 country: China name: Xinxin Zhang role: CONTACT phone: +86 150 6781 0815 email: zhxinxin1122@163.com lat: 27.99942 lon: 120.66682 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2024-01-13 uploadDate: 2024-03-13T05:17 filename: Prot_SAP_000.pdf size: 541225 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-01-16 uploadDate: 2024-03-13T05:18 filename: ICF_001.pdf size: 254239 hasResults: False
nctId: NCT06341894 id: OBU-II-BC-126 briefTitle: Efficacy and Safety of Dalpiciclib With Endocrine Therapy as Adjuvant Treatment in HR+/ HER2- Early Breast Cancer overallStatus: RECRUITING date: 2023-11-17 date: 2027-06 date: 2029-06 date: 2024-04-02 date: 2024-04-02 name: The First Affiliated Hospital with Nanjing Medical University class: OTHER briefSummary: The investigator conduct a phase II multi-center, open-label trial to evaluate efficacy and safety of dalpiciclib with endocrine therapy as adjuvant treatment in patients with medium /high risk hormone receptor-positive, HER2-negative Early Breast Cancer. conditions: Early Breast Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 1163 type: ESTIMATED name: Dalpiciclib name: Endocrine therapy measure: invasive Disease-free Survival (iDFS) measure: Disease-free Survival (DFS) measure: AEs and SAEs sex: FEMALE minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The First Affiliated Hospital of Nanjing Medical University status: RECRUITING city: Nanjing state: Jiangsu country: China name: Xiaoan Liu, Professor role: CONTACT phone: 025-68308162 email: liuxiaoan@126.com lat: 32.06167 lon: 118.77778 hasResults: False
nctId: NCT06341881 id: KMU/DIR/CTU/2024/006 id: KMU-CTU-2024-2001 type: OTHER domain: Khyber Medical University Clinical Trial Unit briefTitle: Understanding the Need and Feasibility of Transitional Care Training Program Among Family Caregivers of Geriatric Stroke Survivors in Pakistan overallStatus: RECRUITING date: 2024-02-27 date: 2024-05 date: 2025-01 date: 2024-04-02 date: 2024-04-02 name: Khyber Medical University Peshawar class: OTHER briefSummary: The main intention of the study is to understand the need and feasibility of transitional care training program among family caregivers of geriatric stroke survivors in Pakistan conditions: Stroke conditions: Stroke, Ischemic conditions: Stroke Hemorrhagic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The most commonly two armed parallel study design would be used to conduct the current study. The study participants in an intervention group would be compared with that of a control group. Equal number of Participants would be allocated with random assignment in the two groups. primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: The study participants would not be informed of what group they are in. Independent outcome assessors would be utilized for the assessment. Further outcomes assessors and data analysts' would be kept unaware of intervention or group allocations to carry out their assessment after inclusion of participants into the study. whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Transitional Care Training Program measure: Physical care measured via Training Evaluation Assessment Checklist (TEAC) Questionnaire measure: Psychological care measured via Training Evaluation Assessment Checklist (TEAC) Questionnaire measure: Social Care measured via Training Evaluation Assessment Checklist (TEAC) measure: Training Need Assessment measure: Training Program Development sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Khyber Medical University status: RECRUITING city: Peshawar state: Khyber Pakhtunkhwa zip: 25000 country: Pakistan name: Sardar Ali, PHD Scholar role: CONTACT phone: +92 349-5182270 email: sardar.ins@kmu.edu.pk lat: 34.008 lon: 71.57849 facility: MTI-HMC (Medical Teaching Institution-Hayatabad Medical Complex), -Peshawar status: RECRUITING city: Peshawar state: Khyber Pakhtunkhwa zip: 25000 country: Pakistan name: Awal Khan, MSN role: CONTACT phone: +92 343 9757103 email: awalkhanmsn@gmail.com name: Sardar Ali, PHD Scholar role: PRINCIPAL_INVESTIGATOR lat: 34.008 lon: 71.57849 facility: MTI-KTH (Medical Teaching Institution-Khyber Teaching Hospital), Peshawar-Pakistan status: RECRUITING city: Peshawar state: Khyber Pakhtunkhwa zip: 25000 country: Pakistan name: Asmat Pasha, MSN role: CONTACT phone: +92 3319205016 email: asmat.pasha@kth.edu.pk lat: 34.008 lon: 71.57849 hasResults: False
nctId: NCT06341868 id: KACH.2023.0067 id: 23KACH008 type: OTHER domain: Keller Army Community Hospital briefTitle: Dynamic Muscular Electrical Stimulation Following Anterior Cruciate Ligament Reconstruction in Military Academy Cadets overallStatus: RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-09-01 date: 2024-04-02 date: 2024-04-02 name: Keller Army Community Hospital class: FED name: Medical Technology Enterprise Consortium briefSummary: The goal of this clinical trial is to examine the effects of 12 weeks of post-operative use of a novel wearable electrical stimulation knee sleeve device (KneeStim) on post-operative biomechanical function (gait). Participants will be United States Military Academy cadets aged 17-27 years. The main questions it aims to answer are:
Researchers will compare a control group (standard of care + KneeStim controlled low intensity) to an experimental group (standard of care + KneeStim flexible intensity) to assess the aims previously mentioned.. conditions: Anterior Cruciate Ligament Injuries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: KneeStim measure: Change in gait post-operatively assessed by the KneeStimTM Device measure: change in gait post-operatively assessed by 3D Motion capture measure: change in gait post-operatively assessed by force plate instrumented treadmill measure: change in muscle volume assessed by MRI measure: ACL graft healing assessed by MRI measure: Change in isometric muscle strength assessed by CSMi HUMAC NORM measure: Change in skeletal muscle mass assessed by bioelectrical impedance analysis (SECA BIA) measure: Change in lean body mass assessed by bioelectrical impedance analysis (SECA BIA) measure: Change in fat mass assessed by bioelectrical impedance analysis (SECA BIA) measure: Change in knee pain and function assessed by the Knee Injury and Osteoarthritis Score (KOOS) measure: Change in knee pain and function assessed by the International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) measure: Change in knee pain assessed by the Patient-Reported Outcome Measure Information System (PROMIS-29) measure: Change in knee function assessed with the Single Assessment Numeric Evaluation Method (SANE) measure: Change in knee function assessed by the Marx Activity Rating Scale (MARS) measure: Impact of ACL surgery on overall quality of life assessed by the Anterior Cruciate Ligament-Quality of Life (ACL-QOL) measure: Change of running gait function from the patients' perspective assessed by the University of Wisconsin Running Injury and Recovery Index (UWRI) measure: Change of knee pain from the patients' perspective assessed by the Visual Analog Scale (VAS) measure: Time to return to full duty sex: ALL minimumAge: 17 Years maximumAge: 27 Years stdAges: CHILD stdAges: ADULT facility: Keller Army Community Hospital status: RECRUITING city: West Point state: New York zip: 10996 country: United States name: Natalia B Prando, BA role: CONTACT phone: 845-938-5325 email: natalia.b.prando.ctr@health.mil name: Paige A McHenry, MS role: CONTACT phone: 845-938-2630 email: paige.a.mchenry.ctr@health.mil lat: 41.39148 lon: -73.95597 hasResults: False
nctId: NCT06341855 id: 23K294001 briefTitle: Exploring the Potential of ctDNA-MRD for Recurrence Surveillance and Prognostic Evaluation in High-risk Endometrial Cancer overallStatus: RECRUITING date: 2024-01-25 date: 2026-01-30 date: 2026-01-30 date: 2024-04-02 date: 2024-04-02 name: The First Hospital of Jilin University class: OTHER name: Geneplus-Beijing Co. Ltd. briefSummary: Patients with high-risk endometrial cancer may have MRD after surgical treatment, which is a potential source of follow-up early recurrence and metastasis, and because of its limited resolution, traditional imaging (including PET/CT) or laboratory methods may not be reliable to detect. For patients with radical treatment, the uncured population can be identified by the detection of MRD, suggesting that patients may benefit from further intervention. The purpose of this study is to explore the prognostic value and recurrence monitoring value of ctDNA-MRD in patients with endometrial carcinoma. conditions: Endometrial Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: NONE count: 100 type: ESTIMATED name: MRD-ctDNA measure: monitoring recurrence and evaluating prognosis measure: Treatment benefit sex: FEMALE minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: the 1st hospital of Jilin University status: RECRUITING city: Chang Chun state: Jilin country: China name: Xiaosen Li Li role: CONTACT phone: +8618343116682 email: xiaosensen@jlu.edu.cn lat: 42.74694 lon: 126.24667 hasResults: False
nctId: NCT06341829 id: PRISM1 briefTitle: Visuospatial and Affective Abilities in Parkinson Disease overallStatus: NOT_YET_RECRUITING date: 2024-04-17 date: 2024-04-18 date: 2026-02-28 date: 2024-04-02 date: 2024-04-16 name: IRCCS Centro Neurolesi "Bonino-Pulejo" class: OTHER briefSummary: The aim of the study is to investigate whether prismatic adaptation (AP), a non-invasive neuromodulation technique, that involves the use of lenses that deviate the visual field, can modulate alexithyima and performance in visuospatial tasks in patients with Parkinson disease. Furthermore, brain activity during the prismatic adaptation and post-adaptation phases will be recorded using functional near-infrared spectroscopy (fNIRS) and high-density electroencephalography (HD-EEG). conditions: Parkinson Disease conditions: Alexithymia conditions: Visuospatial/Perceptual Abilities studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: SINGLE whoMasked: PARTICIPANT count: 63 type: ESTIMATED name: Prismatic adaptation measure: Improve visuospatial skills; measure: Modulate alexithymia; measure: Investigation of brain activity; measure: Improve the quality of life with PDQ-39 questionnaire sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06341816 id: VEXUS2 briefTitle: Treatment According to Venous Excess Ultrasound Score in Patients With Heart Failure overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2024-10-01 date: 2024-12-01 date: 2024-04-02 date: 2024-04-23 name: Inonu University class: OTHER briefSummary: Heart failure is a syndrome that progresses with symptoms and signs caused by cardiac dysfunction and results in a shortened life expectancy (1). Acute heart failure resulting in hospitalization is a significant cause of morbidity and mortality. With the increase in the severity of the disease and rapid advances in the treatment of heart failure, these patients are frequently hospitalized and monitored in intensive care. (2) Five years after diagnosis, mortality can be up to 67%. Additionally, it is known that patients with heart failure are hospitalized on average once a year after diagnosis. (3) In a multicenter study, it constituted 14% of 3000 cardiac patients admitted to intensive care units. Additionally, due to longer ICU stays, these patients accounted for 33% of total inpatient days. An increasing number of heart failure patients require intensive care due to respiratory failure, regardless of left ventricular ejection fraction. Heart failure accounts for approximately one-third of patient days in intensive care units, and this burden is increasing. This shows that attention should be paid to the quality of care for patients requiring critical care. (2) Multidisciplinary programs have been implemented to deal with the high prevalence. However, the optimal follow-up frequency is unknown. Therefore, some tools are needed to improve patient prognosis (3).
Venous load ultrasonography score (VExUS) is a new systemic congestion scoring method based on inferior vena cava dilation and pulsed wave Doppler (PW-Doppler) morphology of the hepatic, portal and renal veins. It has been proposed as a score to assess systemic congestion. conditions: Heart Failure conditions: Acute Kidney Injury studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: VEXUS score name: NGAL measure: acute kidney injury measure: mortality sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06341803 id: DSRB 2023/00397 briefTitle: Personalized Transcranial Magnetic Stimulation Treatment for Depression acronym: APIC-TMS overallStatus: RECRUITING date: 2024-03-01 date: 2025-04-01 date: 2025-12-31 date: 2024-04-02 date: 2024-04-02 name: Institute of Mental Health, Singapore class: OTHER name: National University of Singapore briefSummary: This proposal seeks to conduct a pragmatic single arm, open label pilot implementation to validate our individualized functional Magnetic Resonance Imaging (fMRI) connectome-guided localization approach for accelerated TMS among Asian patients with depression.
The clinical outcome data will be analyzed using linear regression or repeated analysis of variance (ANOVA) after adjusting for baseline clinical characteristics and socio-demographics. Trajectories of the clinical outcome data at baseline, post-treatment and all follow-up time points will be plotted and compared with time series statistical analysis models with the other clinical and socio-demographic characteristics included as confounders. conditions: Depression studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Individually Neuronavigated accelerated intermittent theta burst stimulation with Magpro X100 measure: Montgomery-Åsberg Depression Rating Scale (MADRS) measure: Quick Inventory of Depressive Symptomatology (16-Item) (Self-Report) (QIDS-16) measure: Montreal Cognitive Assessment (MoCA), measure: EuroQol- 5 Dimension (EQ-5D) measure: Quality of Life Enjoyment and Satisfaction Questionnaire Short form (Q-LES-QS-SF) measure: Correlation of changes in functional connectivity with changes in MADRS scores sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Institute of Mental Health status: RECRUITING city: Singapore country: Singapore name: Phern-Chern Tor, MBBS role: CONTACT lat: 1.28967 lon: 103.85007 hasResults: False
nctId: NCT06341790 id: NAFLD-02 briefTitle: Effect of Consumption of Millet Diet in Patients With NAFLD overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2026-07-05 date: 2026-07-05 date: 2024-04-02 date: 2024-04-02 name: Institute of Liver and Biliary Sciences, India class: OTHER briefSummary: With NAFLD fast rising its ranks in becoming a major non communicable disease in India and across the globe, this study aims at primary prevention of the condition. NAFLD is a spectrum of diseases characterised by the deposition of fat within hepatocytes and is a precursor of liver inflammation. Global estimates peg the prevalence to be around 30 to 40%, but there are not many studies which have documented the prevalence in India. With the epidemiological transition, the cases of NAFLD are also on a rise as metabolic syndrome is an important risk factor.
It is apparent that the westernized way of our lifestyle especially the junk food culture comprising of super portions of loads of calories, sugars and salts is the main driver of this nutritional pandemic. The traditional diets in India were rich in fruits and vegetables, low in simple carbohydrates and high in fibre. Cereals are the main source of calories in any diet, forming the base of the food pyramid. Managing our cereals from being refined to the more complex ones being rich in fibre, protein and good quality fat could be a major player in the whole game of dietary modifications not just therapeutically but also prophylactically. Hence our therapeutic focus should be in increasing the consumption of cereals that are not only high in fibre, low in carbohydrates but also that have the potential to modulate the intestinal bacterial ecology to a more favourable type thus helping in intensifying the effects of overall dietary modifications.
Gut microbiota is currently explored for its role in NAFLD and there are gaps in knowledge which preclude having therapeutic strategies through its modulation. Millets, which were once considered to be poor man's diet are now becoming a part of the plate more frequently, especially for its unique nutritive content, with increased fiber, low carbohydrates, high protein and good quality fats. The processing methods may alter glycemic responses. Thus, the present study is proposed to look into the effect of millet based diets in reduction of hepatic steatosis and the resultant alterations in the gut microbiota . conditions: NAFLD studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: jowar based products measure: Assessment of hepatic steatosis in NAFLD patients measure: Assessment of blood sugar measure: Assessment of lipid function measure: Assessment of liver transaminases measure: Assessment of body composition measure: Assessment of Gut Microbiota sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: ILBS city: New Delhi zip: 110070 country: India name: Nida Athar, Msc role: CONTACT phone: 8601079163 email: nidaathar.20@gmail.com lat: 28.63576 lon: 77.22445 hasResults: False