hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06308315 id: REC/RCR&AHS/23/0297 briefTitle: Effects of Rhythmic Balance Auditory Vision Training And Strength Training With Autism Spectrum Disorder. overallStatus: RECRUITING date: 2024-02-25 date: 2024-05-01 date: 2024-05-15 date: 2024-03-13 date: 2024-03-13 name: Riphah International University class: OTHER briefSummary: Autism, a complex neurodevelopmental disorder that is marked by limited interests, and challenges in communication and social interactions and problem includes difficulties in understanding and responding to social cues, repetitive behaviors, intense focus on specific interests, and challenges with verbal and nonverbal communication. Rhythmic Balance Auditory Vision Training (RBAVT) a therapeutic approach which helps in improving coordination and balance in individuals with various neurological conditions. Strength training enhance physical health and muscle development. Thus, the purpose of this study is to compare the effects of rhythmic balance auditory vision training and strength training on motor function and cognition in children with autism spectrum disorder. conditions: Autism Spectrum Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The study would be single blinded as assessor of the study would be kept blind of the treatment groups to which patient would be allocated. whoMasked: OUTCOMES_ASSESSOR count: 76 type: ESTIMATED name: Rhythmic balance visual auditory exercise + Routine physical therapy name: Strength Training + Routine Physical Therapy measure: Bruininks-Oseretsky Test of Motor Proficiency (BOT-2) measure: Wisconsin Card Sorting Test (WCST) sex: ALL minimumAge: 6 Years maximumAge: 12 Years stdAges: CHILD facility: Riphah International University status: RECRUITING city: Lahore state: Punjab zip: 54660 country: Pakistan name: Muhammad Kashif, PhD-PT role: CONTACT phone: 03333125303 email: Kashif.shaffi@riphah.edu.pk lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06308302 id: REC/RCR&AHS/23/0355 briefTitle: Comparative Effects of IMT Vs EMT Along With AIT in COPD Patients overallStatus: COMPLETED date: 2023-05-23 date: 2024-01-30 date: 2024-02-15 date: 2024-03-13 date: 2024-03-13 name: Riphah International University class: OTHER briefSummary: Chronic Obstructive Pulmonary Disease (COPD) is the 3rd leading cause of mortality and 7th leading cause of ill-health worldwide. It is characterized by persistent and progressive air flow resistance with expiratory flow more compromised as compared to inspiratory flow leading to CO2 retention and prominent hyperinflation of lungs. The overall effects of COPD on the patient's entire body include pulmonary, followed by extra-pulmonary manifestations in which musculoskeletal derangements are more pronounced and interfere with daily activities, further deteriorating the patient's health. Restricted air flow leads to an increase in shortness of breath on slight exertion and early fatigue or exhaustion of respiratory muscles due to over work. Literature from the past describes how COPD care has advanced and emphasizes the value of pulmonary rehabilitation in addition to medicinal management to treat decadence. Many studies show that Inspiratory muscle training has positive effect on ABG's, some PFT's and diaphragmatic function. Endurance and strength training improve patient activity of daily living and dyspnea.
This study intricate the collation of Respiratory Muscle Training and Aerobic Interval Training on functional performance, exertional dyspnea and fatigue level in patients diagnosed with COPD. A randomized controlled trial will be integrated with the sample size of 53 patients which is calculated through epi-tool. Age of selected Patients will fall between 30-55 years and will be randomly assigned into 2 groups. Group A (Experimental group A) will get Inspiratory breather training along-with Aerobic Interval Training, Group B (Experimental group B) will get Expiratory muscle training along-with Aerobic Interval Training (Same Protocol). Data will be gathered from Pulmonology wards and OPD of selected hospital. Clinical Assessment will be incorporated through Karnofsky performance scale, Fatigue Severity Scale, MmRC Dyspnea scale, Digital Spirometer, and 6MWT. Pre-intervention assessment measures and Post-intervention measures will be noted and results will be compared. Study Duration will be of 06 months after approval of synopsis. Data analysis will be done through SPSS.
Key words: Aerobic Interval training (AIT), The Breather Device (BD), 6-min walk test (6MWT), Fatigue severity scale (FSS), Modified Medical Research Council dyspnea scale (mMRC), Chronic Obstructive Pulmonary Disease (COPD). conditions: COPD studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: PARTICIPANT count: 53 type: ACTUAL name: Group A (Inspiratory Muscles Training + Aerobic Interval Training) name: Group B (Expiratory Muscles Training +Aerobic Interval Training) measure: Modified Medical Research Council (mMRC) Dyspnea Scale measure: 6 Minute Walk Test measure: Karnofsky Performance Scale (KPS) measure: Fatigue Severity Scale (FSS) measure: FEV1 measure: FVC measure: FEV1/FVC sex: ALL minimumAge: 30 Years maximumAge: 55 Years stdAges: ADULT facility: Al-Zahra Rehabilitation Center, Gulab Devi Teaching Hospital city: Lahore state: Punjab zip: 42000 country: Pakistan lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06308289 id: REC/RCR&AHS/23/0361 briefTitle: Combined Effects of Global Posture Re-education and Active Cycle of Breathing Technique in COPD overallStatus: RECRUITING date: 2024-03-03 date: 2024-06-05 date: 2024-06-15 date: 2024-03-13 date: 2024-03-13 name: Riphah International University class: OTHER briefSummary: The randomized controlled trial will involve 30 participants, with Group A receiving GPRM and ACBT, while Group B follows the conventional COPD model that includes ACBT only.Assessments of heart rate, physical fitness, and quality of life will contribute to a nuanced understanding of joint function, informing future COPD treatment paradigms. conditions: Chronic Obstructive Pulmonary Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized controlled trial primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 68 type: ESTIMATED name: Global Posture Re-education name: Active Cycle of Breathing Technique measure: SF- 36 Questionnaire measure: FEV1/FVC ratio measure: 6-minute walk test measure: Photogrammetry measure: Forced expiratory volume (FEV1) measure: Forced vital capacity (FVC) sex: ALL minimumAge: 40 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Social Security Hospital status: RECRUITING city: Gujranwala state: Punjab zip: 52200 country: Pakistan name: Akhtar Hunjra, Phd role: CONTACT phone: 03041049249 email: ms.sshgw@pessi.punjab.gov.pk name: Komal Munir, DPT role: SUB_INVESTIGATOR lat: 32.15567 lon: 74.18705 hasResults: False
nctId: NCT06308276 id: REC/RCR&AHS/23/0363 briefTitle: Effects of Aerobic Versus Resistance Training in Post Percutaneous Coronary Intervention Obese Patients overallStatus: RECRUITING date: 2024-03-01 date: 2024-06-05 date: 2024-06-15 date: 2024-03-13 date: 2024-03-13 name: Riphah International University class: OTHER briefSummary: The randomized clinical trial (RCT) endeavors to enroll 50 participants, divided equally into aerobic exercise and resistance exercise groups. The study employs rigorous tools such as blood pressure measurement, SF-36 questionnaire, and the Six-Minute Walk Test (6MWT) to assess VO2max. conditions: Cardiovascular Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized Clinical Trial primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Aerobic Training name: Resistance Training measure: Blood Pressure measure: Six Minute Walk Test measure: SF 36 Questionnaire sex: ALL minimumAge: 40 Years maximumAge: 60 Years stdAges: ADULT facility: Sialkot Medical and Physiotherapy Center status: RECRUITING city: Sialkot state: Punjab zip: 51310 country: Pakistan name: Fasih Ahmed Rehmani, MS-OMPT role: CONTACT phone: 03348005240 email: Fasih12190@gmail.com name: Teenat Fatima, DPT role: SUB_INVESTIGATOR lat: 32.49268 lon: 74.53134 hasResults: False
nctId: NCT06308250 id: REC/RCR&AHS/23/0294 briefTitle: Comparative Effects of Mime Therapy and Action Observation Therapy in Bell's Palsy overallStatus: RECRUITING date: 2024-02-25 date: 2024-05-01 date: 2024-05-15 date: 2024-03-13 date: 2024-03-13 name: Riphah International University class: OTHER briefSummary: The aim of this study is to determine comparative effects of mime therapy and action observation therapy on facial symmetry and quality of life in Bell's palsy. Bell's palsy is characterized as an abrupt paralysis of the peripheral facial nerve, typically without a known cause. Mime Therapy is a performing technique that helps patients regain the ability to use their face muscles. Action observation therapy is novel rehabilitation approach exploiting this mirror mechanism. conditions: Bell Palsy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The study would be single blinded as assessor of the study would be kept blind of the treatment groups to which patient will be allocated. whoMasked: OUTCOMES_ASSESSOR count: 62 type: ESTIMATED name: MIME THERAPY name: ACTION OBSERVATION THERAPY measure: Sunny Brook Facial Grading System measure: Facial Disability Index sex: ALL minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Riphah International University status: RECRUITING city: Lahore state: Punjab zip: 54660 country: Pakistan name: Muhammad Kashif, PhD-PT role: CONTACT phone: 03333125303 email: kashif.shaffi@riphah.edu.pk lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06308237 id: REC/RCR&AHS/23/0293 briefTitle: Effects of Resisted Versus Balance Exercises on Cognitive And Motor Function In Patients With Mild Cognitive Impairment overallStatus: RECRUITING date: 2024-02-25 date: 2024-06-20 date: 2024-06-25 date: 2024-03-13 date: 2024-03-13 name: Riphah International University class: OTHER briefSummary: Mild cognitive impairment affects older adults and it includes memory and attentions deficits, and problem-solving difficulties in activities of daily living. Resisted exercises is considered a viable strategy to improve balance and motor function in older population. Balance exercises comprises proprioceptive, visual and motor learning to a larger degree and has positive effects on memory and spatial cognition and improves balance and motor function. This study aims to determine the effects of resisted and balance exercises on cognition and motor function in patients with mild cognitive impairment. conditions: Mild Cognitive Impairment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The study would be single blinded as assessor of the study would be kept blind of the treatment groups to which patient will be allocated. whoMasked: OUTCOMES_ASSESSOR count: 66 type: ESTIMATED name: RESISTED EXERCISES name: BALANCE EXERCISES measure: MoCA (Montreal Cognitive Assessment ) measure: Mini-Balance Evaluation Systems Test (BESTest). measure: Timed UP and GO Test (TUG) : measure: Computerized battery test (CBT) sex: ALL minimumAge: 60 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Riphah International University status: RECRUITING city: Lahore state: Punjab zip: 54660 country: Pakistan name: Muhammad Kashif, PhD-PT role: CONTACT phone: 03333125303 email: kashif.shaffi@gmail.com lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06308224 id: REC/RCR&AHS/23/0290 briefTitle: Comparison of Modified-Otago and Tai Chi Exercises in Patients With Stroke overallStatus: RECRUITING date: 2024-02-25 date: 2024-05-01 date: 2024-05-24 date: 2024-03-13 date: 2024-03-13 name: Riphah International University class: OTHER briefSummary: The study aims to determine the comparative effects of Modified-Otago and Tai Chi Exercises on Balance and Motor Function in Patients with Stroke. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The study would be single-blinded as the assessor of the study would be kept blind of the treatment groups to which the patient would be allocated. whoMasked: OUTCOMES_ASSESSOR count: 64 type: ESTIMATED name: Modified-Otago Exercises name: Tai-Chi Exercises measure: Berg Balance Scale (BBS) measure: Timed Up and Go (TUG) measure: Motor Assessment Scale (MAS) sex: ALL minimumAge: 40 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Riphah International University status: RECRUITING city: Lahore state: Punjab zip: 54660 country: Pakistan name: Muhammad Kashif, PhD-PT role: CONTACT phone: 03333125303 name: Muhammad Kashif, PhD-PT role: CONTACT phone: 03333125303 email: kahif.shaffi@riphah.edu.pk lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06308211 id: REC/RCR&AHS/23/0289 briefTitle: Comparative Effects of Motor Imagery and Mirror Therapy Versus Motor Relearning Program in Subacute Stroke Patients overallStatus: RECRUITING date: 2024-02-25 date: 2024-05-01 date: 2024-05-15 date: 2024-03-13 date: 2024-03-13 name: Riphah International University class: OTHER briefSummary: Use of motor imagery, mirror therapy and motor relearning program in rehabilitation of people with stroke is on rise and these are unique and emerging techniques. Motor imagery is a mental rehearsal through visualization while mirror therapy creates a reflection of non-effected limb by using a mirror. Moreover, motor relearning is task-oriented approach, benefacial for balance and motor funCtion in patients with stroke that emphasizes on relearning.The aim of the study is to determine the comparative effects of motor imagery and mirror therapy versus motor relearning program in addition to routine physical therapy on balance, motor function and activities of daily living in subacute stroke patients. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The study would be single blinded as assessor of the study would be kept blind of the treatment groups to which patient would be allocated. whoMasked: OUTCOMES_ASSESSOR count: 42 type: ESTIMATED name: MOTOR IMAGERY+MIRROR THERAPY+ROUTINE PHYSICAL THERAPY name: MOTOR RELEARNING PROGRAM+ROUTINE PHYSICAL THERAPY measure: Berg balance scale (BBS) measure: FUGL-MEYER ASSESMENT (FMA) measure: FUNCTIONAL INDEPENDENCE MEASURE (FIM) sex: ALL minimumAge: 40 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Muhammad Kashif status: RECRUITING city: Lahore state: Punjab zip: 54660 country: Pakistan name: Muhammad Kashif, Phd role: CONTACT phone: 03333125303 email: kashif.shaffi@gmail.com lat: 31.558 lon: 74.35071 hasResults: False
nctId: NCT06308198 id: M24-008 briefTitle: A Study to Evaluate AGN-151586 Intramuscular Injections in Adult Participants for Treatment of Glabellar Lines overallStatus: RECRUITING date: 2024-03-29 date: 2025-03-22 date: 2025-03-22 date: 2024-03-13 date: 2024-04-29 name: AbbVie class: INDUSTRY briefSummary: Facial lines that develop from repeated facial expression, such as glabellar lines (GL), are typically treated by selectively weakening specific muscles with small quantities of botulinum toxin. The purpose of this study is to evaluate the safety and efficacy of AGN-151586 compared to placebo in adult participants.
AGN-151586 is an investigational product being developed for the treatment of GL. In the first period, participants are randomly assigned to receive AGN-151586 or placebo. Each group receives a different treatment. There is a 1 in 3 chance that participants will be assigned to placebo. In the second period, all participants who meet retreatment criteria will receive open-label AGN-151586. Around 160 participants will be enrolled in the study at approximately 14 sites in China, Taiwan, and Japan.
nctId: NCT06308185 id: EPINEO briefTitle: Neonatal Seizures: Semiology, Etiology, Therapy and Prognosis Correlations overallStatus: ACTIVE_NOT_RECRUITING date: 2021-06-01 date: 2023-12-31 date: 2024-07-01 date: 2024-03-13 date: 2024-03-13 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico class: OTHER briefSummary: Epileptic seizures in newborns (often called "neonatal convulsions") represent the most frequent neurological problem in newborns (1-3/1000 newborns). The type of seizure and their etiology is very varied and therefore the therapeutic protocol also requires adaptations with a personalization of the therapeutic approach according to the characteristics of the case according to principles of precision medicine in particular for forms of neonatal epilepsy compared to epileptic seizures acute symptomatic. In recent years it has been highlighted that the clinical characterization and instrumental characterization, in particular electroencephalographic, of epileptic seizures represents an important biomarker that allows the choice of therapy to be oriented appropriately. In the literature there is a lack of single-center studies that relate the type of crisis according to the new ILAE 2017 classification (Fisher 2017) and its proposal for neonatal adaptation (Pressler 2021) with the etiology, type of therapy and outcome neurological after a few years.
The secondary aim is to evaluate the correlation between seizure type and etiology with effective therapy, length of hospitalization and neurobehavioral development outcome. The study design is a retrospective observational on the population of neonates managed at our center in the last decade. conditions: Neonatal Seizure conditions: Epilepsy studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 140 type: ACTUAL name: observational study measure: Seizure Type and etiology correlation measure: EEG and etiology correlation measure: Etiology and and effective drug correlation measure: Etiology and neurobehavioral outcome correlation sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico city: Milan zip: 20122 country: Italy lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06308172 id: CSI/2021 briefTitle: Impact of Single- Versus Double-layer Hysterotomy Closure on Cesarean Niche Development: a Randomized Controlled Trial overallStatus: RECRUITING date: 2021-12-01 date: 2024-12-01 date: 2026-12-01 date: 2024-03-13 date: 2024-03-13 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico class: OTHER briefSummary: The objective of this randomized monocentric study is to assess potential variations in the incidence and severity of isthmocele morbidity among women undergoing cesarean section with either single or double-layer closure of the hysterotomy. Our primary outcome aims to investigate whether there is a reduction in the median duration of intermenstrual spotting in patients belonging to the two respective closure groups conditions: Cesarean Section; Dehiscence conditions: Uterine Bleeding conditions: Uterus; Scar conditions: Uterus Abnormal conditions: Cesarean Section Complications studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE maskingDescription: Patients are recruited and randomly assigned to either the "single-layer" or "double-layer" arm of the study. The randomization process occurs on the day of the cesarean section. Following randomization, patients are informed about their assigned group, and the cesarean section procedure is then carried out. count: 150 type: ESTIMATED name: Hysterotomy closure measure: Intermenstrual bleeding reduction (days) measure: Intra-operatory time measure: Blood loss measure: Analgesics measure: Post-operatory recovery time measure: Time to full patient mobilization measure: Isthmocele sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione Cà Granda IRCCS Ospedale Maggiore Policlinico di Milano status: RECRUITING city: Milan state: Mi zip: 20122 country: Italy name: Giuseppe Perugino, MD role: CONTACT phone: 3383030553 email: giuseppe.perugino@policlinico.mi.it name: Floriana Carbone, MD role: SUB_INVESTIGATOR name: Ottavio Cassardo, MD role: SUB_INVESTIGATOR lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06308159 id: LT02-101 briefTitle: An Open-label Study of a Gene Therapy Product in Beta-Thalassemia overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-04-01 date: 2027-04-01 date: 2024-03-13 date: 2024-03-13 name: Lantu Biopharma class: INDUSTRY briefSummary: This is an interventional study to evaluate the safety and efficacy of autologous Hematopoietic Stem Cells (HSCs) transduced with lentiviral vector encoding functional hemoglobin subunit beta (HBB) gene in patients with transfusion-dependent beta-thalassemia. conditions: Beta-Thalassemia studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 3 type: ESTIMATED name: Vebeglogene autotemcel measure: Time and duration of the subject's hemoglobin (Hb)≥9.0 g/dL without receiving red blood cell infusion measure: The prevalence and severity of adverse events (AEs) and serious adverse events (SAEs) measure: The reduction of red blood cells (RBCs) transfusion requirement after product infusion compared to previous transfusion records measure: Number of days required to achieve successful neutrophil and platelet engraftment measure: Vector copy number (VCN) in peripheral blood over time sex: ALL minimumAge: 12 Years maximumAge: 35 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06308146 id: S21-1249496 briefTitle: Effect of Bacillus Subtilis ATCC 122264 Supplementation on Gas Symptoms and Quality of Life in Participants With Functional Bloating overallStatus: COMPLETED date: 2022-04-21 date: 2022-10-11 date: 2022-10-11 date: 2024-03-13 date: 2024-03-15 name: Kerry Group P.L.C class: INDUSTRY name: Nutrasource Pharmaceutical and Nutraceutical Services, Inc. briefSummary: A randomized, double blind, placebo-controlled, 2-arm parallel study to evaluate the efficacy of Bacillus subtillis in providing relief and improving quality of life in participants suffering from functional abdominal bloating/distension when administered for a period of 8 weeks. conditions: Functional Bloating studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants will be randomly assigned in a 1:1 ratio to receive either the probiotic or placebo. Study products (i.e., TP and placebo) will be dispensed by the site as per the randomization scheme at the study visits. primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: To minimize bias, the sponsor representatives involved in the study, the investigator, the participants, and any healthcare professionals or site personnel involved in participant management or outcome assessment remained blinded to interventional assignments whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ACTUAL name: Bacillus subtilis ATCC 122264 name: Placebo measure: Effect on intestinal gas symptoms and quality of life measure: Effect on intestinal gas symptoms and quality of life sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Apex Trials city: Guelph state: Ontario zip: N1G 0B4 country: Canada lat: 43.54594 lon: -80.25599 hasResults: False