hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06274398 id: RITE Study briefTitle: Rectal Insert TAF/EVG Pre-Exposure Prophylaxis (RITE PrEP) Study acronym: RITE PrEP overallStatus: RECRUITING date: 2024-01-16 date: 2024-10-31 date: 2024-12-31 date: 2024-02-23 date: 2024-02-23 name: Eastern Virginia Medical School class: OTHER name: CONRAD name: Emory University name: Centers for Disease Control and Prevention briefSummary: This is a double-blind, placebo-controlled, randomized two-phase study to evaluate the safety and pharmacokinetics (PK) of two TAF/EVG inserts administered rectally for 3 consecutive days, then every other day for 14 days. conditions: Safety Issues studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized, Placebo-controlled, Double-blind primaryPurpose: OTHER masking: QUADRUPLE maskingDescription: Double-blind whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: TAF/EVG rectal insert name: Matching placebo rectal insert measure: Frequency and intensity of Adverse Events measure: Pharmacokinetics (PK) (maximum concentration (Cmax)) in blood measure: PK (Cmax) in rectal secretions measure: PK (Cmax) in rectal mucosal tissue measure: PK (Cmax) in cervicovaginal secretions measure: PK (Cmax) in cerviocovaginal mucosal tissues measure: Cytokine Profiles measure: Microbiome Profiles sex: ALL minimumAge: 18 Years maximumAge: 59 Years stdAges: ADULT facility: Emory Clinic status: RECRUITING city: Atlanta state: Georgia zip: 30322 country: United States name: Cassie Grimsley Ackerley, MD, MSc role: CONTACT email: cassie.marie.grimsley.ackerley@emory.edu lat: 33.749 lon: -84.38798 hasResults: False
nctId: NCT06274385 id: 2311010178 briefTitle: The Effects of an Acute Dose of a Betalain-rich Concentrate on Repeated-sprint Cycling Performance and Recovery. acronym: BET_RSE overallStatus: RECRUITING date: 2024-02 date: 2024-06 date: 2024-06 date: 2024-02-23 date: 2024-02-23 name: Drexel University class: OTHER briefSummary: Betalains have well-known antioxidant and anti-inflammatory properties. Recent investigations examining the effects of a betalain-rich concentrate (BRC) on exercise and recovery performance show promise of BRC as an ergogenic aid. To date, no study has examined the effects of a single dose of a BRC on supramaximal performance and recovery. Therefore, the purpose of this study is to examine the effects of an acute dose of BRC on repeated-sprint cycling performance and recovery. conditions: Nutraceuticals studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 10 type: ESTIMATED name: Betalain-rich concentrate (AltRed) name: Placebo measure: Repeated Sprint Performance measure: Neuromuscular Fatigue sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Drexel University - Health Sciences Building status: RECRUITING city: Philadelphia state: Pennsylvania zip: 19102 country: United States name: Arun Ramakrishnan, PhD role: CONTACT phone: 215-553-7018 email: ar88@drexel.edu lat: 39.95233 lon: -75.16379 hasResults: False
nctId: NCT06274372 id: FCV,V-2202 briefTitle: The Effect of Flow-controlled Ventilation on Hemodynamic and Respiratory Parameters in Laparoscopic Surgeries overallStatus: ACTIVE_NOT_RECRUITING date: 2023-08-07 date: 2024-08-06 date: 2024-08-06 date: 2024-02-23 date: 2024-03-06 name: Derince Training and Research Hospital class: OTHER briefSummary: It is aimed to investigate the effect of flow controlled ventilation on intraoperative respiratory parameters and hemodynamic parameters in laparoscopic operations. conditions: Laparoscopic Surgeries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE whoMasked: PARTICIPANT count: 30 type: ESTIMATED name: flow controlled ventilation name: volume controlled ventilation measure: effects of flow controlled ventilation on heamodynamic parameters measure: effectcs of flow controlled ventiletion on respiratory parameters measure: effects of flow controlled ventilation on heamodynamic parameters measure: effects of flow controlled ventilation on heamodynamic parameters measure: effectcs of flow controlled ventiletion on respiratory parameters measure: respiratory related complications sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kocaeli Derince Training and Research Hospital city: Derince state: Kocaeli zip: 41900 country: Turkey hasResults: False
nctId: NCT06274359 id: 21-3985 briefTitle: Digital Storytelling to Reduce Pediatric Influenza Vaccination Disparities overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-03-31 date: 2027-08-31 date: 2024-02-23 date: 2024-02-23 name: Denver Health and Hospital Authority class: OTHER briefSummary: While the COVID-19 pandemic has highlighted health disparities, Black children have unduly suffered and died from seasonal influenza for decades. Through sustained partnership with Black community stakeholders, novel community-engaged research methods, and an innovative intervention approach, this proposal will explore, develop, and test a Digital Storytelling intervention to reduce influenza vaccination disparities in Black children aged 6 months to 5 years. This project will advance our understanding of engagement methods and interventions that improve health equity and serve as a model for future work to address vaccination disparities, ensuring all individuals have the chance to fulfill their potential free of preventable diseases. conditions: Influenza studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Caregivers will be assigned randomly to receive a series of digital stories by text message or to receive usual care. primaryPurpose: PREVENTION masking: SINGLE whoMasked: INVESTIGATOR count: 200 type: ESTIMATED name: Digital storytelling measure: Child influenza vaccination status at influenza season's end (defined as March 31, 2025 for season 1 and March 31, 2026 for season 2 if a 2nd season of recruitment is necessary) measure: Intervention Feasibility measure: Intervention Acceptability measure: Intervention Appropriateness sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Denver Health Eastside Clinic city: Denver state: Colorado zip: 80205 country: United States lat: 39.73915 lon: -104.9847 facility: Denver Health Park Hill Clinic city: Denver state: Colorado zip: 80207 country: United States lat: 39.73915 lon: -104.9847 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-01-26 uploadDate: 2024-01-30T11:52 filename: ICF_000.pdf size: 298169 hasResults: False
nctId: NCT06274346 id: ahmedU briefTitle: Effect of Retro Walking Versus Isometric Multi-angular Exercises on Pain and Functional Performance in Knee Osteoarthritis in Geriatric Population overallStatus: COMPLETED date: 2023-06-01 date: 2023-11-10 date: 2023-11-30 date: 2024-02-23 date: 2024-02-23 name: Delta University for Science and Technology class: OTHER briefSummary: Osteoarthritis is a leading musculoskeletal cause of disability in elderly persons all over the world and a major cause of physical limitations and reduced quality of life (1). Its onset is around 40 years of age and it is estimated that over 80% of people over 55 have evidence of radiographic changes in the knee due to osteoarthritis. It has been estimated that the incidence has increased by the increase in life expectancy and it has been identified as a frequent cause for health services demand in patients over 65(2).
Isometric exercises are types of strength training in which the joint angle and muscle length do not change during contraction, and therefore this approach can be advantageous in the early stages of knee rehabilitation in cases where the range of motion is restricted due to pain (13). No physical work is performed during isometric exercise. Intensity and duration combination reflects the energy consumption of an isometric contraction (14). In addition, muscle strength increases in isometric exercise are specific to the angle applied. It was also concluded that isometric exercise performed at different angles should be especially considered as an alternative strength training since it induces the most noticeable and fastest increase in muscle moment (15). A study was conducted to investigate the effects of isometric quadriceps exercise on muscle strength, pain, and function in knee osteoarthritis, it was concluded that isometric quadriceps exercise program showed beneficial effects on quadriceps muscle strength, pain, and functional disability in patients with osteoarthritis of the knee (16).
Another study was conducted to assess the effectiveness of Isometric exercise and counseling on level of pain among patients with Knee osteoarthritis, the authors concluded that Isometric exercise and counseling program has significantly reduced pain, stiffness and improved physical function and the authors recommended that Isometric exercise and counselling should be adopted as a routine care in the hospitals treating patients with knee osteoarthritis (17) Thus, we hypothesized that a less intensive walking program such as retro walking program could provide an additional benefit more than those experienced by forward walking program in the previous studies. Therefore, the primary aim of the present study was to compare the effect of retro walking versus isometric multiangular exercises group on knee pain and function in geriatric people.
We recorded the height, weight, and medical history, and lower extremity dominance, level of education, occupation and duration of complaints of each patient. All were evaluated at the beginning of the treatment (week 0), at the endpoint of the treatment (week 4) conditions: Knee Osteoarthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients were randomly assigned into two groups through computer software. We put sixty patients on the software program and the program assigned them randomly. s exercise, straight leg raise, prone knee bending, side lying hip abduction, prone hip extension with 5 seconds hold and a rest interval of 2 seconds for 10 repetitions for each exercise for a period of 4 weeks, 3 days per week was given. Second group was treated by retrowalking exercises in addition to physical therapy interventions including short wave diathermy and strengthening exercise such as static quadriceps exercise, dynamic quadriceps exercise, straight leg raise, prone knee bending, side lying hip abduction, prone hip extension with 5 seconds hold and a rest interval of 2 seconds for 10 repetitions for each exercise for a period of 4 weeks, 3 days per week was given., which were given 3 times/week for 4 consecutive weeks. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Sixty male and female geriatric patients had chronic knee osteoarthritis were chosen the outpatient clinic of faculty of physical therapy, Delta University for science and technology. education, occupation and duration of complaints of each patient. All were evaluated at the beginning of the treatment (week 0), at the endpoint of the treatment (week 4). whoMasked: PARTICIPANT count: 60 type: ACTUAL name: Multiangular Isometric exercise measure: Pain intensity measure: Functional assessment: sex: ALL minimumAge: 60 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Delta University For Science and Technology city: Gamasa state: Almansourah zip: 38733 country: Egypt lat: 31.44112 lon: 31.53675 hasResults: False
nctId: NCT06274333 id: RC.18.1.2024 briefTitle: Adding Dexmedetomidine or Tramadol to Paracetamol- An Effort to Attenuate Catheter Related Bladder Discomfort overallStatus: RECRUITING date: 2024-02-28 date: 2024-05-30 date: 2024-05-30 date: 2024-02-23 date: 2024-03-15 name: Al-Azhar University class: OTHER name: Benha University briefSummary: The insertion of a urinary catheter in a patient undergoing a surgical procedure, especially urinary interventions, may lead to catheter-related bladder discomfort (CRBD) with varying degrees of severity during the postoperative period. Paracetamol is a drug with proven efficacy for the management of mild and moderate postoperative pain. Tramadol is a centrally acting, synthetic opioid analgesic with weak opioid agonist properties. It inhibits the detrusor activity by inhibition of type-1 muscarinic (M1) and type-3 muscarinic (M3) receptors. Dexmedetomidine, a highly selective α2-adrenergic receptor agonist, with analgesic, sedative, anxiolysis, sympatholytic, and sedative properties, is a very useful associated agent for general anesthesia. conditions: Percutaneous Nephrolithotripsy (PCNL) studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Dexmedetomidine 0.5 mic/kg name: Tramadol 1mg/kg name: Paracetamol 10mg/kg measure: The incidence of catheter-related bladder discomfort (CRBD) measure: Postoperative pain measure: Meperidine requirement measure: Patient satisfaction measure: Surgeon satisfaction sex: MALE minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT facility: Neveen Kohaf status: RECRUITING city: Cairo zip: 11865 country: Egypt name: Neveen Kohaf, Ph.D role: CONTACT phone: +201069482380 email: nevenabdo@azhar.edu.eg name: Hany Bauiomy, M.D role: PRINCIPAL_INVESTIGATOR name: Ahmed M. Abosakaya, M.D role: PRINCIPAL_INVESTIGATOR lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06274320 id: LRP22002 LIPIKAR UREA 30% briefTitle: Effect of Lipikar Urea 30% Before Actinic Keratoses Treatment overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-10 date: 2024-10 date: 2024-02-23 date: 2024-02-28 name: Cosmetique Active International class: INDUSTRY briefSummary: This study is conducted in one center in Germany, in adult subjects having actinic keratoses (grade I or II) lesions on the scalp and meeting specific inclusion/exclusion criteria. The purpose of the study is to evaluate a holistic management (efficacy, tolerability and lesion cosmetic outcomes) of Tolak® treatment. conditions: Actinic Keratoses studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: TRIPLE whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Group A: holistic approach name: Group B: Tolak® Standard of use measure: Change in lesion response rate measure: Percentage change sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CentroDerm GmbH city: Wuppertal country: Germany lat: 51.27027 lon: 7.16755 hasResults: False
nctId: NCT06274307 id: IRB-21-10-4045 briefTitle: Efficacy of Transversus Abdominis Plane Block overallStatus: RECRUITING date: 2023-06-22 date: 2024-07-01 date: 2024-09-01 date: 2024-02-23 date: 2024-02-23 name: Justin Hruska class: OTHER briefSummary: This study aims to assess the efficacy of Transversus Abdominus Plane (TAP) blocks, a well-established anesthetic technique, to decrease the amount of post-operative pain in patients who undergo minimally invasive gynecologic surgeries. During minimally invasive gynecologic surgeries, the abdomen is inflated with pressurized air for visualization purposes and released at the end of the surgery. Traditionally, TAP blocks are performed by injecting long-acting local anesthetic agents under ultrasound guidance into the abdominal wall after abdominal surgery after the air has been emptied from the abdomen for additional anesthetic coverage post-operatively. This study proposes a novel approach: that performing TAP blocks while the abdomen is still insufflated will result in better post-operative pain outcomes as compared to the traditional method. conditions: Anesthesia, Local studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The treatment group (Group 1) will have a transversus abdominis plane (TAP) block performed with an insufflated abdomen in the operating room. The control group (Group 2) will receive the traditionally performed standard of care TAP block performed in the post-anesthesia care unit primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: The patient will be unaware of their grouping allotment. The outcomes assessor will be unaware of the patient grouping allotment. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: Transversus abdominis plane block measure: Time to perform TAP Block measure: TAP block attempts measure: Pain Score Visual Analog Scale (VAS) 0 Hours Post Surgery measure: Pain Score Visual Analog Scale (VAS) 1 Hours Post Surgery measure: Pain Score Visual Analog Scale (VAS) 2 Hours Post Surgery measure: Pain Score Visual Analog Scale (VAS) 4 Hours Post Surgery measure: Pain Score Visual Analog Scale (VAS) 24 Hours Post Surgery measure: Postoperative Opioid Consumption measure: Ease of performing TAP Block-anatomical plane visualization measure: Ease of performing TAP Block-performance efficacy measure: Patient satisfaction sex: FEMALE minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Detroit Medical Center Detroit Receiving Hospital status: RECRUITING city: Detroit state: Michigan zip: 48201 country: United States name: George M McKelvey, PhD role: CONTACT phone: 313-598-6036 email: gmckelve@dmc.org name: Justin Hruska, M.D. role: PRINCIPAL_INVESTIGATOR lat: 42.33143 lon: -83.04575 facility: Detroit Medical Center, Harper University Hospital status: RECRUITING city: Detroit state: Michigan zip: 48201 country: United States name: George M McKelvey, PhD role: CONTACT phone: 313-598-6036 email: gmckelve@dmc.org name: Justin Hruska, MD role: PRINCIPAL_INVESTIGATOR lat: 42.33143 lon: -83.04575 hasResults: False
nctId: NCT06274294 id: 2023/12 briefTitle: Pharmacokinetics, Efficacy and Safety of CT-P13 Subcutaneous as Induction Therapy in Patients With Active CD or UC acronym: PASSPORT overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-01 date: 2025-01 date: 2024-02-23 date: 2024-02-23 name: CMC Ambroise Paré class: OTHER name: Paris IBD Center name: Celltrion HealthCare France briefSummary: The goal of this clinical trial is to compare induction treatment with CT-P13 SC to induction treatment with CT-P13 IV in terms of pharmacokinetics in adult patients with inflammatory bowel disease (IBD) who have been diagnosed for at least 3 months and for whom the physician has decided to initiate treatment with infliximab CT-P13 as part of the standard of care.
The main aim of this study is to demonstrate that induction treatment with CT-P13 SC is non-inferior to CT-P13 IV in terms of pharmacokinetics at Week 6. conditions: Inflammatory Bowel Diseases studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The full sample size comprises 130 patients, with 65 patients allocated to each arm. The arms are defined as follows:
* Control Arm: Patients receive CT-P13 IV at weeks 0 and 2, followed by subcutaneous administration every two weeks until week 24. primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 130 type: ESTIMATED name: CT-P13 measure: Ratio SC/IV measure: Ctrough at week 24 (non-inferiority) measure: AUC at week 24 measure: Clinical response at week 6 and week 24 measure: IBD disability index at week 6 measure: Fecal calprotectin at week 24 measure: Clinical remission at week 6 and week 24 measure: Presence of antibodies to infliximab at Week 6 and Week 24 measure: Concentration of C-reactive protein up to week 6 (the samples are collected at weeks 0, 6 and 24) measure: Adverse events, including injection site reactions and hypersensitivity reactions measure: TSQM collected at Week 6 and Week 24 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06274281 id: TOMs_FMD briefTitle: Digital Telerehabilitation in Functional Motor Disorders overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-02-01 date: 2026-02-01 date: 2024-02-23 date: 2024-02-23 name: Universita di Verona class: OTHER briefSummary: Functional motor disorders (FMDs) are a broad spectrum of functional neurological disorders, including abnormal gait/balance disorders. Patients experience high degrees of disability and distress, equivalent to those suffering from degenerative neurological diseases. Rehabilitation is essential in their management. However, the current systems of rehabilitation delivery face two main challenges. Patients are not receiving the amount and kind of evidence-based rehabilitation they need due to the lack of rehabilitation professionals and experts in the field. The rehabilitation setting is not adequate for the long-term management and monitoring of these patients. Digital medicine is a new field that means "using digital tools to upgrade the practice of medicine to one that is high-definition and far more individualized." It can upgrade rehabilitation practice, addressing the existing critical components towards marked efficiency and productivity. Digital telerehabilitation will increase the accessibility to personalized rehabilitation by expert professionals placing tools to monitor the patient's health by themselves.
This feasibility study provides preliminary data on the integration of a real-time gait and activity analysis by wearable devices in the real world with a digital platform to improve the diagnosis, monitoring, and rehabilitation of patients with FMDs. conditions: Functional Movement Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is an experimental single-blind randomized-controlled trial (RCT) with 2-parallel arms comparing the effects between the experimental group (EG) and control group (CG). After screening, a simple randomization list will be generated by a physician using an automated randomization system (alloca-tion ratio 1:1) to assign eligible patients to either the EG or the CG. Group allocation will be kept concealed. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The outcome assessor will be blinded to the type of intervention performed by the patient. whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Digital Telerehabilitation name: Usual care measure: number of patients who accept/refuse the treatment, physiotherapy compliance and falls or event near falling occurred during rehabilitation measure: Budget issues related to TOMs measure: Time spent to train patients measure: Change in the Simplified Functional Movement Disorders Rating Scale (S-FMDRS) score measure: Multidimensional Fatigue Inventory Scale (MFI-20) score measure: Change in the Brief Pain Inventory (BPI) score measure: Change in the Beck Depression Inventory (BDI-II) score measure: Change in the Beck Anxiety Inventory (BAI) score measure: Change in the 12-item Short-Form Health Survey (SF-12) score measure: The EuroQol-5D (EQ-5D) measure: iMTA Productivity Cost Questionnaire measure: Change in the Clinical Global Impression (CGI) score measure: Gait outcome: Gait speed measure: Gait outcome: Stride length measure: Gait outcome: Cadence measure: Balance outcome: CoP trajectory measure: Balance outcomes: Sway area sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona city: Verona zip: 37131 country: Italy lat: 45.4299 lon: 10.98444 facility: USD Parkinson's Disease and Movement Disorders Unit city: Verona zip: 37134 country: Italy lat: 45.4299 lon: 10.98444 hasResults: False