The main objective is to compare the addition of Abacavir/Lamivudine (Add-on) to standard care for 6 months, on the value of the interferon (IFN) transcriptomic signature of patients with systemic lupus with low activity as defined by the Lupus Low Disease Activity State (LLDAS). conditions: Systemic Lupus Erythematosus studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Open-label randomized, controlled study with 2 parallel arms (Add-on treatment versus standard of care treatment) primaryPurpose: TREATMENT masking: NONE count: 70 type: ESTIMATED name: Blood sample name: Treatment :Abacavir 600 mg/lamivudine 300 mg name: Lupus Impact Tracker questionnaire measure: Absolute variation in interferon signature (IFN) measure: percentage of patients maintaining LLDAS criteria measure: number of relapses measure: anti-native double-stranded DNA quantification measure: anti-extractable nuclear antigens (anti-ENA) quantification measure: interferon-α production quantification measure: Number of successful patients measure: Cumulative dose of intravenous (IV) corticosteroids measure: Lupus Impact Tracker questionnaire score measure: number of missed treatment measure: number of adverse event (AE) measure: number of serious adverse event (SAE) measure: HERVs transcription quantification sex: ALL minimumAge: 12 Years maximumAge: 65 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Groupe Hospitalier Pellegrin-CHU de Bordeaux city: Bordeaux zip: 33076 country: France name: Christophe RICHEZ, MD, PhD role: CONTACT phone: 05 56 79 56 79 phoneExt: +33 email: christophe.richez@chu-bordeaux.fr name: Christophe RICHEZ, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 44.84044 lon: -0.5805 facility: Hôpital Femme-Mère-Enfant (HCL) city: Bron zip: 69677 country: France name: Alexandre BELOT, MD, PhD role: CONTACT phone: 04 27 85 61 26 phoneExt: +33 email: Alexandre.belot@chu-lyon.fr name: Alexandre BELOT, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 45.73333 lon: 4.91667 facility: CHU de Clermont-Ferrand - Hôpital Gabriel Montpied city: Clermont-Ferrand zip: 63003 country: France name: Marc ANDRE, MD, PhD role: CONTACT phone: 0473751440 phoneExt: +33 email: mandre@chu-clermontferrand.fr name: Marc ANDRE, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 45.77966 lon: 3.08628 facility: CHU Nord de Grenoble - Albert Michallon city: Grenoble zip: 38043 country: France name: Laurence BOUILLET, MD, PhD role: CONTACT phone: 04 76 76 76 40 phoneExt: +33 email: lbouillet@chu-grenoble.fr name: Laurence BOUILLET, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 45.16667 lon: 5.71667 facility: Hôpital Claude Huriez city: Lille zip: 59037 country: France name: Éric HACHULLA, MD, PhD role: CONTACT phone: 03 20 44 56 50 phoneExt: +33 email: eric.hachulla@chru-lille.fr name: Éric HACHULLA, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 50.63297 lon: 3.05858 facility: Hôpital de la Croix-Rousse (HCL) city: Lyon zip: 69004 country: France name: Yvan JAMILLOUX, MD, PhD role: CONTACT phone: 0426732636 phoneExt: +33 email: yvan.jamilloux@chu-lyon.fr name: Yvan JAMILLOUX, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 45.74848 lon: 4.84669 facility: Hôpital Edouard Herriot (HCL) city: Lyon zip: 69437 country: France name: Thomas BARBA, MD role: CONTACT phone: 0472119583 phoneExt: +33 email: thomas.barba@chu-lyon.fr name: Thomas BARBA, MD role: PRINCIPAL_INVESTIGATOR lat: 45.74848 lon: 4.84669 facility: Hôpital Necker-Enfants malades city: Paris zip: 75015 country: France name: Brigitte BADER-MEUNIER, MD role: CONTACT phone: 0144494332 phoneExt: +33 email: brigitte.bader-meunier@aphp.fr name: Brigitte BADER-MEUNIER, MD role: PRINCIPAL_INVESTIGATOR lat: 48.85341 lon: 2.3488 facility: Hôpital Pitié-Salpêtrière city: Paris zip: 75651 country: France name: Zahir AMOURA, MD, PhD role: CONTACT phone: 01 42 17 80 01 phoneExt: +33 email: zahir.amoura@aphp.fr name: Zahir AMOURA, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 48.85341 lon: 2.3488 facility: Hôpital Lyon Sud (HCL) city: Pierre-Bénite zip: 69310 country: France name: Mael Richard, MD role: CONTACT phone: 0478861352 phoneExt: +33 email: mael.richard@chu-lyon.fr name: Mael Richard, MD role: PRINCIPAL_INVESTIGATOR lat: 45.7009 lon: 4.82511 facility: CHU de Saint-Etienne - Hôpital Nord city: Saint-Priest-en-Jarez zip: 42270 country: France name: Martin KILLIAN, MD, PhD role: CONTACT phone: 04 77 82 91 79 phoneExt: +33 email: martin.killian@chu-st-etienne.fr name: Martin KILLIAN, MD, PhD role: PRINCIPAL_INVESTIGATOR lat: 45.47501 lon: 4.37614 hasResults: False