nctId: NCT06294730 id: 2018/1891-31 briefTitle: COronary Microcirculation and Troponin Elevation in Septic Shock acronym: COMTESS overallStatus: RECRUITING date: 2019-06-13 date: 2024-06 date: 2024-12 date: 2024-03-05 date: 2024-03-05 name: Karolinska Institutet class: OTHER briefSummary: Plasma cardiac troponin (cTn) elevation is an indicator of increased mortality in patients with sepsis yet the underlying cause of troponin elevation in sepsis is not known. The COMTESS study investigates whether elevated high-sensitive cardiac Troponin T (hs-cTnT) levels in hemodynamically unstable patients with sepsis can be explained by an underlying coronary artery disease or a process within the coronary microcirculation. Fifty patients with sepsis and with hs-cTnT elevation (\>15 ng/L) will undergo coronary angiography, including an assessment of coronary flow using a method called thermo-dilution to record the index of microcirculatory resistance (IMR) in the left anterior descending artery (LAD). The relationship between IMR and hs-cTnT will subsequently be analysed. It is important to identify the underlying causes of elevated cTn during sepsis to target further research with an aim to improve the survival in patients suffering from this condition. conditions: Sepsis conditions: Myocardial Injury conditions: Coronary Microvascular Dysfunction conditions: Endothelial Dysfunction studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED measure: Relationship between hs-cTnT and IMR measure: Relationship between hs-cTnT and CFR measure: Relationship between hs-cTnT and BRI measure: Relationship between hs-cTnT and number of diseased epicardial coronary vessels measure: Relationship between hs-cTnT and Synergy Between PCI With Taxus and Cardiac Surgery (SYNTAX)-score measure: Relationship between hs-cTnT and left ventricular end diastolic pressure (LVEDP) measure: Relationship between hs-cTnT and Tricuspid annular plane systolic excursion (TAPSE) measure: Relationship between hs-cTnT and echocardiographic measurements of left ventricular global strain measure: Relationship between hs-cTnT and echocardiographic measurements of left diastolic dysfunction measure: Relationship between measures of endothelial dysfunction and IMR measure: Relationship between measures NETs and IMR sex: ALL minimumAge: 40 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Karolinska Institutet, Danderyd University Hospital status: RECRUITING city: Stockholm zip: 182 88 country: Sweden name: Jonas Persson, MD, PhD role: CONTACT phone: +46 70-089 1412 email: jonas.persson@regionstockholm.se name: Samantha Lörstad, MD role: CONTACT phone: +46708693973 email: samantha.rutherford-lorstad@regionstockholm.se name: Jonas Persson, MD, PhD role: PRINCIPAL_INVESTIGATOR name: Samantha Lörstad, MD role: SUB_INVESTIGATOR name: Tomas Jernberg, MD, PhD role: SUB_INVESTIGATOR name: Sara Tehrani, MD, PhD role: SUB_INVESTIGATOR name: Per Åstrand, MD role: SUB_INVESTIGATOR name: Christina Ekenbäck, MD role: SUB_INVESTIGATOR name: Fadi Jokhaji, MD role: SUB_INVESTIGATOR name: Kambiz Shahgaldi, PhD role: SUB_INVESTIGATOR name: Charlotte Thålin, MD, PhD role: SUB_INVESTIGATOR name: Patrik Gille-Johnson, MD, PhD role: SUB_INVESTIGATOR lat: 59.33258 lon: 18.0649 hasResults: False