hackint0sh/New-Dataset huggingface dataset:
Participants will be randomised into two groups. Patients assigned to the PENG group will receive spinal anaesthesia with local anaesthetic (isobaric bupivacaine) alone and a PENG block. Patients assigned to the intrathecal morphine (ITM) group will receive spinal anaesthesia with a mixture of local anaesthetic (isobaric bupivacaine) and morphine (100 mcg) and a sham PENG block to ensure patient blinding. conditions: Analgesia conditions: Hip Arthropathy conditions: Post Operative Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: single centered, prospective, double blinded non inferiority trial primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: quadruple whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Intrathecal morphine name: Pericapsular nerve group block (PENG) measure: Cumulative postoperative morphine consumption at day 1 measure: Morphine consumption in the recovery room measure: PCA administered morphine consumption at day 2 measure: rest and dynamic pain scores measure: Incidence of postoperative nausea and vomiting measure: Incidence of pruritus measure: Incidence of urinary retention requiring bladder catheterisation measure: Duration of analgesia measure: operated limb quadriceps strength measure: Walking test sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital of Lausanne city: Lausanne state: Vaud zip: 1011 country: Switzerland name: Marta Szyszko du Bois d'Aische role: CONTACT phone: +41795564002 email: marta.szyszko@chuv.ch name: Corey Kull role: CONTACT phone: +41795561781 email: corey.kull@chuv.ch lat: 46.516 lon: 6.63282 hasResults: False
nctId: NCT06317857 id: 14422021443228 briefTitle: Clinical Performance of an Alkasite-based Restorative Material overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-06-30 date: 2025-06-30 date: 2024-03-19 date: 2024-03-19 name: Cairo University class: OTHER briefSummary: The evolution of restorative dental materials and technology has enabled the use of tooth-colored restorative materials in dental restorations, with all dentists hoping for the presence of materials that combine biocompatible qualities and aesthetics . Although resin composite materials' mechanical and aesthetic properties have greatly improved over the past 20 years, research is currently on to find ways to prevent secondary caries from forming beneath and at the margins of restorations. In order to circumvent these problems, there is a growing tendency towards the use of resin-based bioactive and remineralizing restorative materials to strengthen and lengthen the lifespan of bonded dental restorations. conditions: Caries, Dental studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 68 type: ESTIMATED name: Centio Forte measure: Retention success rate % with modified USPH criteria measure: Marginal adaptation with modified USPH criteria marginal discolouration, recurrent caries, anatomic form and postoperative sensitivity. measure: Postoperative sensitivity sex: ALL minimumAge: 16 Years maximumAge: 55 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06317844 id: BlackHillsHealthPsych id: P20GM103443 type: NIH link: https://reporter.nih.gov/quickSearch/P20GM103443 briefTitle: Examination of Psychological and Physiological Pathways Linking Gratitude and Pain overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2026-08 date: 2027-05 date: 2024-03-19 date: 2024-03-19 name: Black Hills State University class: OTHER name: National Institute of General Medical Sciences (NIGMS) briefSummary: The goal of this clinical trial is to compare the effects of a brief gratitude intervention on individuals' psychological and physiological responses to acute pain. Furthermore, these associations will be examined in the context of genetic variations associated with both pain and psychological processes. conditions: Acute Pain conditions: Positive Thinking conditions: Emotions studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: NONE count: 300 type: ESTIMATED name: Behavioral Writing Intervention measure: Change in Subjective Pain Ratings from Baseline to 10-minutes Post Cold Pressor Test measure: Differences in Pain Tolerance to Cold Pressor Test measure: Differences in Pain Onset to Cold Pressor Test measure: Differences in Pain-Related Cognition measure: Differences in Autonomic Nervous System Responsivity sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06317831 id: 2023.03936.BDANA briefTitle: LetS Get fUnctional! FuNctional Status in pEople With intersTitial Lung Disease acronym: SUNSET overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-12-30 date: 2028-07-30 date: 2024-03-19 date: 2024-03-19 name: Aveiro University class: OTHER name: Fundação para a Ciência e a Tecnologia briefSummary: This study aims to i) To characterize the functional status and explore the determinants of functional status decline of people with IlD ii)To determine the measurement properties of functional status instruments in people with Interstitial lung diseases (ILD) iii) To identify the impact of ILD and the participants' perspectives on functional status through interviews iv) Explore the progression of functional status progression in people with ILD and v) Develop a multidimensional index, incorporating functional status parameters, to predict mortality in people with ILD.
Patients with ILD will be recruited via the pulmonology services at hospitals, namely from Centro Hospitalar de Vila Nova de Gaia/Espinho (CHVNG/E), Centro Hospitalar do Baixo Vouga (CHBV) and Centro Hospitalar de Entre o Douro e Vouga (CHEDV). Sociodemographic, clinical characteristics (i.e., smoking habits, vital signs and symptoms), anthropometric (i.e., height and weight to compute body mass index) and general clinical data (i.e., medication, oxygen therapy, non-invasive ventilation, acute exacerbations, hospitalizations and number of hospital admissions in the last month and year, length of stay), as well as prior and follow-up spirometric measurements and arterial blood gas will be collected from clinical records for patients' characterization. Mortality and rehospitalizations will be explored during the study period. Peripheral muscle strength, functional status, daily physical activity, self-reported symptoms, functional status, impact of the disease and health-related quality of life. Qualitative data from interviews.
It is expected that: i) Functional status limitations can be comprehensively identified and measured in individuals with ILD. ii) Some measures are valid and reliable indicators of functional status in individuals with ILD. iii) Different profiles of functional status progression will be identified in individuals with ILD, including stable, slow, and fast decline. iv) A multidimensional index incorporating functional status will improve the accuracy of predicting mortality and outperform the predictive ability of the current GAP Index. conditions: Interstitial Lung Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 150 type: ESTIMATED measure: Short physical performance battery (SPPB) measure: Six Minute Walk Test (6MWT) measure: The 1-minute sit-to-stand measure: The grocery shelving task measure: The Physical Performance Test (PPT) measure: Handgrip strenght measure: Peripheral muscle strength measure: The Tilburg Frailty Indicator (TFI) measure: The Canadian Occupational Performance Measure (COPM) measure: Symptoms of fatigue measure: Symptoms of fatigue measure: Symptoms of dyspnoea measure: The Pulmonary Functional Status and Dyspnea Questionnaire Modified version (PFSDQ-M) measure: Health-related quality of life (HRQOL) measure: Health-related quality of life (HRQOL) measure: London Chest Activities of Daily Living (LCADL) measure: Daily physical activity measure: Qualitative data: Interviews measure: Number of hospitalizations measure: Acute exacerbations measure: Non-invasive ventilation measure: Oxygen therapy measure: Medication measure: Mortality measure: Weight measure: Height measure: Body mass index measure: Heart rate measure: Respiratory rate measure: Blood pressure measure: Peripheral Oxygen Saturation sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Aveiro city: Aveiro zip: 3810-193 country: Portugal lat: 40.64427 lon: -8.64554 hasResults: False
nctId: NCT06317818 id: TJT2301 briefTitle: Is Local Injection of Mesenchymal Stem Cells After Endoscopic Dilation Safe and Does it Improve the Outcome of Intestinal Stricture in Patients With Crohn's Disease? overallStatus: RECRUITING date: 2023-06-06 date: 2025-08 date: 2025-08 date: 2024-03-19 date: 2024-03-19 name: Centre Hospitalier Universitaire de Liege class: OTHER briefSummary: This is an exploratory phase II study, to evaluate the impact of these Mesenchymal Stem Cells (MSCs) on strictures in Crohn's disease patients with symptomatic intestinal stricture eligible to endoscopic dilatation. The impact of combined treatment by endoscopic dilation and local injection of MSCs will be compared with that of a control group. conditions: Safety Issues conditions: Efficacy studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized, double-blind, controlled study primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Mesenchymal Stem Cells name: Comparative placebo measure: Assessment of safety of local MSCs injection, in association with endoscopic dilation, in strictures of patients with Crohn's disease. measure: Assessment of efficacy of local MSCs injection, in association with endoscopic dilation, in strictures of patients with Crohn's disease by evaluating symptomatic clinical response measure: Assessment of efficacy of local MSCs injection, in association with endoscopic dilation, in strictures of patients with Crohn's disease by evaluating endoscopic response measure: Assessment of efficacy of local MSCs injection, in association with endoscopic dilation, in strictures of patients with Crohn's disease by evaluating radiological response measure: Evaluation of studying, in addition to biomarkers (CRP and fecal calprotectin), sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU de Liège status: RECRUITING city: Liège zip: 4000 country: Belgium name: Sophie Vieujean, MD role: CONTACT phone: + 32 4 323 72 56 email: s.vieujean@chuliege.be name: Layla Boutaffala role: CONTACT phone: +32 4 323 38 10 email: lboutaffala@chuliege.be lat: 50.63373 lon: 5.56749 hasResults: False
nctId: NCT06317805 id: TREV1-10P.401 id: 2023-504351-26-01 type: CTIS briefTitle: Initial Triple Therapy Including Parenteral Treprostinil vs Initial Double Oral Therapy in PAH Group I Patients acronym: TripleTRE overallStatus: RECRUITING date: 2023-12-06 date: 2027-06 date: 2027-06-30 date: 2024-03-19 date: 2024-03-19 name: AOP Orphan Pharmaceuticals AG class: INDUSTRY name: ANOVA CRO s.r.o. name: PharmaLex Belgium name: Aixial s.r.o. name: GCP-Service International Ltd. & Co. KG briefSummary: TripleTRE investigates the effect of initial triple combination therapy (oral endothelin receptor antagonist (ERA) + oral phosphodiesterase tyüe-5 inhibitor (PDE-5i) + parenteral treprostinil) compared to double oral therapy (oral ERA + oral PDE-5i) in pulmonary arterial hypertension (PAH) patients (group I) with intermediate-high risk or patients with intermediate-low risk with severe hemodynamic impairment at baseline in a prospective, randomized, unblinded setting with scope of increasing evidence for optimization of therapy concepts in PAH.
nctId: NCT06317792 id: 202201719B0 briefTitle: The Efficacy of Online Exergaming-Integrated Physiotherapy for Parkinson's Disease overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-03-31 date: 2026-06-30 date: 2024-03-19 date: 2024-03-19 name: Chang Gung Memorial Hospital class: OTHER name: National Science and Technology Council briefSummary: To validate the efficiency of online exergaming-based physiotherapy. We will enroll patients with Parkinson's disease in postural instability and gait disturbance motor phenotype in the study and divide them into two groups in a randomized controlled study. conditions: Parkinsonism in Diseases Classified Elsewhere studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants will be divided into two groups in a randomized controlled study primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: online exergaming-based physiotherapy programs measure: Unified Parkinson's Disease Rating Scale score assessment measure: Tinetti balance and gait score assessment measure: Fall Risk assessment using Berg Balance Scale measure: Depression severity assessment sex: ALL minimumAge: 20 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine city: Kaohsiung zip: 83304 country: Taiwan lat: 22.61626 lon: 120.31333 hasResults: False
nctId: NCT06317779 id: abdominal laparotomy briefTitle: Evaluation of Laparoscopic Cholecystectomy and Concomitant Paraumbilical Hernia Repair overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-02-01 date: 2027-03-01 date: 2024-03-19 date: 2024-03-19 name: Assiut University class: OTHER briefSummary: Umbilical hernia frequently accompanies cholelithiasis. It is possible to repair these hernias after completing cholecystectomy. conditions: Abdominal Disorder studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 50 type: ESTIMATED measure: Evaluation of Laparoscopic cholecystectomy and concomitant paraumbilical hernia repair measure: Secondary outcomes measures sex: ALL minimumAge: 10 Years maximumAge: 90 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06317766 id: UC 20-2023 briefTitle: Histological Study of the Effects of a 2910 nm Fiber Laser Technology overallStatus: ENROLLING_BY_INVITATION date: 2024-02-05 date: 2024-04 date: 2024-05 date: 2024-03-19 date: 2024-03-19 name: FA Corporation class: INDUSTRY name: University of Texas Southwestern Medical Center briefSummary: The goal of this interventional clinical study is to conduct a comprehensive evaluation of the 2910 nm fiber laser focusing on its diverse energy settings. 2 subjects will be recruited for this 2 part histology study. The main This study will provide valuable insights into the device\'s capabilities and expand knowledge of its clinical utility. The first part of this study is intended to optimize treatment parameters based on observed effects at the molecular level. The second part will investigate the state of tissue at different timepoints following treatment.
* On the day of their procedure, a member of the study team will administer 1 final pulse immediately post-surgery and all 5 timepoints will be harvested for analysis. conditions: Skin Laxity studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: NONE count: 2 type: ESTIMATED name: 2910 nm Fiber Laser Treatment; Pre-Clinical Histology Evaluation name: 2910 nm Fiber Laser Treatment; Part 2 Histology Evaluation measure: TUNEL Staining measure: Mason's Trichrome sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UT Soutwestern Medical Center city: Dallas state: Texas zip: 75390 country: United States lat: 32.78306 lon: -96.80667 hasResults: False
nctId: NCT06317753 id: UMinho1 briefTitle: Can Exercise Rewire the Brain Addiction Circuitry? acronym: REWIRED overallStatus: NOT_YET_RECRUITING date: 2025-01 date: 2027-12 date: 2027-12 date: 2024-03-19 date: 2024-03-22 name: University of Minho class: OTHER briefSummary: The aim of the present study is to apply neuroimaging techniques to investigate how physical exercise may influence the addiction circuitry, ultimately reducing alcohol consumption and craving in youth binge drinkers. This proposal will advance knowledge on how exercise may modulate the neurocircuitry of addiction. Uncovering the neurobiological mechanisms underlying the interactive neural effects of exercise and alcohol intake may provide additional scientific insights for the development of preventive and intervention programs for youth BD and AUD. conditions: Physical Exercise studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The protocol includes a randomized controlled trial with a follow-up at three months involving three groups of adolescents (18-24 Y) -experimental group 1, will be enrolled in the Aerobic program, experimental group 2 will be involved in the agility program, and an active control group that will be participating in a stretching program. Participants will be randomly assigned to each group. primaryPurpose: PREVENTION masking: NONE count: 60 type: ESTIMATED name: Aerobic Exercise name: Agility-Cognitive Exercise name: Stretching/relaxation measure: Behavioral: alcohol consumption measure: Behavioral: binge episodes measure: Behavioral : drunkenness measure: Psychological (craving levels) measure: Brain structure measure: Brain structural connectivity- FA measure: Brain structural connectivity - MD measure: Brain structural connectivity - AD measure: Brain structural connectivity - RD measure: Brain function measure: Brain function-resting state measure: Monetary Incentive Delay Task (included in the fMRI paradigm) - hits measure: Monetary Incentive Delay Task (included in the fMRI paradigm) - reaction time measure: Maximal oxygen consumption (VO2max) measure: Brain-derived neurotrophic factor (BDNF) measure: Dopamine sex: ALL minimumAge: 18 Years maximumAge: 24 Years stdAges: ADULT hasResults: False
nctId: NCT06317740 id: 0306369 briefTitle: Green Management Intervention Program For Nurse Managers overallStatus: COMPLETED date: 2023-04-01 date: 2023-12-31 date: 2023-12-31 date: 2024-03-19 date: 2024-03-19 name: Matrouh University class: OTHER briefSummary: Green management is the organization-wide strategy that aims to integrate environmental sustainability development into organizational management procedures for maintaining safety and striving high quality of care. The study aimed to examine the effect of a randomized trial of a green management intervention program on nurse manager outcomes. conditions: Intervention conditions: Knowledge, Attitudes, Practice studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A randomized controlled trial using two-group pretest-posttest designs primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE maskingDescription: The study was carried out as a randomized controlled trial using two-group pretest-posttest designs in which the intervention group received an intervention program, in contrast to the comparison group. The study design of the present work followed the CONSORT 2010statement whoMasked: PARTICIPANT count: 200 type: ACTUAL name: green management intervention program measure: Questionnaire to measure nurse managers' knowledge measure: Questionnaires to measure nurse manager outcomes sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Nursing, Matrouh University city: Marsa Matruh zip: 002 country: Egypt lat: 31.3529 lon: 27.23725 hasResults: False
nctId: NCT06317727 id: IRAS 337105 briefTitle: PULSed Field ablAtion of coloRectal Polyps acronym: PULSAR overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-11 date: 2030-05 date: 2024-03-19 date: 2024-03-19 name: King's College Hospital NHS Trust class: OTHER name: Mirai Medical briefSummary: The goal of this observational study is to learn about the role of electroporation (the use of small electric pulses applied to tissue) in the treatment (ablation) of colorectal polyps. The main questions to answer in this pilot phase of the study are:
2. The efficacy and feasibility of PFA in the treatment of colorectal polyps using metrics such as treatment coverage, treatment time, post treatment fibrosis, post treatment recurrence and patient satisfaction conditions: Colon Polyp studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED name: Irreversible Electroporation using EndoVE(Endoscopic Vacuum Electrode) and electrical pulses generated using ePORE(electroporation device) measure: Incidence of Treatment-Emergent Adverse Events measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps measure: Evaluation of Quality of Life following pulsed field ablation treatment of colorectal polyps sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06317714 id: IR-2023/0002 id: 2023-A02233-42 type: OTHER domain: ANSM briefTitle: Long-term Follow-up and Quality of Life of Patients Treated With Anticancer Drugs acronym: THERAPINNOV overallStatus: RECRUITING date: 2024-03-08 date: 2027-03-08 date: 2027-03-08 date: 2024-03-19 date: 2024-03-19 name: Institut Rafael class: OTHER briefSummary: Currently, aspects related to the effects of anticancer treatments and the quality of life of patients and their needs are still poorly documented at the Rafael Institute. Thus this study will meet a dual objective: (1) the establishment of a registry to collect data on the safety and effectiveness of innovative and expensive anticancer drugs when administered in real life and (2) a measurement quantitative quality of life of patients treated with these drugs. conditions: Oncology conditions: Quality of Life conditions: Symptoms and Signs studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 300 type: ESTIMATED name: questionnaires measure: overall survival measure: progression free survival measure: incidence of adverse events measure: incidence of serious adverse events measure: Change from Baseline in European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QoL) Questionnaire Core 30 (QLQ-C30) Score measure: change from baseline in quality of life measured with the EQ5D5L questionnaire sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Institute Rafaël status: RECRUITING city: Levallois Perret state: Institut Rafael zip: 92300 country: France name: Alain Toledano role: CONTACT phone: 33 (0)1 47 58 05 96 lat: 48.89389 lon: 2.28864 hasResults: False