hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06296758 id: SiFi_HIP FRACTURE briefTitle: SiFi vs FNB Local Anesthesia for Hip Fracture Surgeries overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05-01 date: 2026-05-01 date: 2024-03-06 date: 2024-03-06 name: University of Alberta class: OTHER briefSummary: The goal of this clinical trial is to compare two commonly used local/regional anesthesia techniques in adults patients undergoing hip fracture surgery. The main question\[s\] it aims to answer are: • the impact of both interventions on patient level of pain. • impact on postoperative analgesics administered Participants will be randomly assigned to one of two local/regional anesthesia techniques, either femoral nerve block (FNB) or suprainguinal fascia iliaca block (SiFi). Both techniques are the usual practice at the hospital, and we are NOT aiming to experiment on new anesthesia technique in this study. conditions: Hip Fractures conditions: Surgery conditions: Anesthesia, Local studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A concealed-allocation parallel-group blinded randomized controlled clinical primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Randomization will be conducted through blocked randomization with blocks of 4 according to a schedule not known to the investigators using a computerized algorithm. The attending surgeon, anesthetist, and nursing team will be blinded to the randomization assignment. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 106 type: ESTIMATED name: Regional anesthesia measure: Postoperative pain measure: Postoperative analgesics administered measure: Mobilization measure: Time to readiness for discharge measure: Complications sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Alberta Hospital city: Edmonton state: Alberta zip: t6g2b7 country: Canada lat: 53.55014 lon: -113.46871 hasResults: False
nctId: NCT06296745 id: 2024-KY-008-01 briefTitle: Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib. overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2026-01-20 date: 2026-03-20 date: 2024-03-06 date: 2024-03-06 name: Guangzhou Medical University class: OTHER briefSummary: Pemetrexed is one of the first-line chemotherapeutic agents for non-squamous non-small cell lung cancer (NSCLC). Since 2017, intrathecal pemetrexed has shown good efficacy for patients with leptomeningeal metastases from NSCLC. It has been recommended as the preferred drug for intrathecal chemotherapy by the Chinese Society of Clinical Oncology (CSCO) guidelines. Tyrosine kinase inhibitors (TKIs) play a promising role in treating non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations. An international multi-center clinical study published in 2019 confirmed that double dose of osimertinib showed significant improvement in leptomeningeal metastases from NSCLC with EGFR exon 19 deletion or exon 21 L858R/T790M mutation. It makes TKIs the mainstay of treatment for patients with EGFR-mutant NSCLC with leptomeningeal metastases. However, the choice of treatment after resistance to targeted therapy is a hot topic in clinical practice, with 78% of patients in the study above who responded to double-dose osimertinib still showing progression at the time of follow-up. The purpose of this study was to observe the safety and efficacy of intrathecal pemetrexed for leptomeningeal metastasis from lung adenocarcinoma that progressed after a double dose of a third-generation TKI such as osimertinib. conditions: Leptomeningeal Metastasis studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 36 type: ESTIMATED name: Pemetrexed measure: Clinical response rate measure: Neurological progression-free survival (NPFS) measure: Overall survival measure: Incidence of treatment-related adverse events sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06296732 id: NCPHOI-2024-01 briefTitle: Abdominal Neuroblastoma Laparoscopic Surgery Risk Factors Stratification acronym: ANLAP-R overallStatus: RECRUITING date: 2023-10-19 date: 2026-10-26 date: 2031-11-01 date: 2024-03-06 date: 2024-03-06 name: Federal Research Institute of Pediatric Hematology, Oncology and Immunology class: OTHER name: Corporate Fund University Medical Centre briefSummary: Surgery plays significant role in treatment of neurogenic tumors, both for benign ganglioneuroma and for high risk neuroblastoma. The world literature has accumulated large experience in laparoscopic surgery for abdominal neuroblastoma. The presence of IDRF (image-defined risk factors) and tumor size (\>4-7 cm) are considered as common contraindications for minimally invasive surgery in neuroblastoma. However, the recent studies have shown that presence of IDRF is not an absolute contraindication for laparoscopic surgery. This open-label, nonrandomized, observational, phase III evaluates role and weight of different surgical risk factors (including IDRF, tumor size, tumor localization, tumor volume/patient height ratio, previous open surgical procedures, previous chemotherapy etc.) in the laparoscopic neuroblastoma resections. The aim of this study is to create novel risk factors scoring system for laparoscopic surgery in abdominal neuroblastoma. conditions: Neuroblastoma conditions: Ganglioneuroma conditions: Ganglioneuroblastoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED name: Duration of surgery intervention measure: Duration of surgery intervention measure: The influence of surgical risk factors measure: Cases of conversion from laparoscopic to cavity access measure: Comparison of surgeon's visual assessment of the tumor resection measure: 1-, 3-, 5-years local recurrence-free survival sex: ALL minimumAge: 1 Day maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Research Institute of Pediatric Hematology, Oncology and Immunology status: RECRUITING city: Moscow country: Russian Federation name: Dmitry m Akhaladze, MD, Doc role: CONTACT phone: +7 (905) 587-89-92, email: d.g.akhaladze@gmail.com lat: 55.75222 lon: 37.61556 hasResults: False
nctId: NCT06296719 id: ACP Community 2024 briefTitle: The Chit-Chat Educational Intervention to Promote Advance Care Planning in the Community overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2025-06 date: 2024-03-06 date: 2024-03-06 name: The Hong Kong Polytechnic University class: OTHER briefSummary: The purpose of this study is to estimate the effect size of the Chit-Chat intervention on ACP engagement among family members of older adults with multi-morbidity. conditions: Old Age conditions: Family Members studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Chit-Chat measure: ACP engagement measure: Knowledge of ACP sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06296706 id: HB1801-010 briefTitle: A Clinical Study of Docetaxel for Injection (Albumin-bound) in Patients With Gastric Cancer overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-06-01 date: 2027-06-01 date: 2024-03-06 date: 2024-03-06 name: CSPC ZhongQi Pharmaceutical Technology Co., Ltd. class: INDUSTRY briefSummary: This trial is a multicenter, randomized, controlled phase Ш clinical study of comparison of Docetaxel for Injection (Albumin-bound) and Taxotere in locally advanced or metastatic gastric adenocarcinoma or gastroesophageal junction adenocarcinoma with previous first-line treatment failure. conditions: Gastric Cancer studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 630 type: ESTIMATED name: Docetaxel for injection (Albumin-bound) name: Taxotere (docetaxel) measure: OS measure: ORR by IRC measure: ORR by investigator measure: PFS measure: DCR measure: DoR measure: AE and SAE measure: Plasma concentration of docetaxel (free and total) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06296693 id: 2023.062(051-DEFI/053-CE) briefTitle: Diagnostic Accuracy of Pocket-size Lung Ultrasound in Pneumonia Etiology and Complications in Hospitalized Children acronym: POCUS-L overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2025-04-30 date: 2024-03-06 date: 2024-03-06 name: Centro Hospitalar Universitário de Santo António class: OTHER briefSummary: 1. Background and study aims Pneumonia is the leading infectious cause of death in children worldwide. Although the diagnosis is clinical, a chest radiograph (CXR) is often necessary to clarify it, exposing the patient to radiation. Ultrasound has been increasingly used in the evaluation of the lung parenchyma without exposing patients to radiation. The pocket-size Point-of-Care Ultrasound (POCUS) can be used at the patient's bedside proving comfort and saving time. Evidence suggests that ultrasound can detect CAP (community-acquired pneumonia) in children with similar accuracy and reliability as CXR. However, few studies evaluated the ability to distinguish the aetiology of pneumonia and none used a pocket-size POCUS device. This study aims to assess, for the first time, the diagnostic accuracy of a pocket-size POCUS device for the etiological diagnosis of CAP vs. CXR, in paediatric ages. Secondarily, the investigators intend to evaluate the correlation between CXR image vs. ultrasound, the correlation between clinical progression and ultrasound images, and the diagnostic accuracy to detect complications.
The recruitment period is expected to start in January/2024 and end in January 2025. conditions: Pneumonia conditions: Pneumonia, Viral conditions: Pneumonia, Bacterial studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 76 type: ESTIMATED name: Pocket-size lung ultrasound for etiological definition of pneumonia and surveillance of complications in children hospitalized measure: POCUS vs. CXR for the etiological diagnosis of CAP measure: CXR image vs. ultrasound measure: Clinical progression and ultrasound images measure: Complications sex: ALL minimumAge: 12 Months maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06296680 id: EGE_UNI_SEVCAN_OZ_KAHVECI_0001 briefTitle: Reiki for Cancer: Pain, Anxiety, and Stress overallStatus: COMPLETED date: 2022-09-02 date: 2022-11-30 date: 2023-06-30 date: 2024-03-06 date: 2024-03-06 name: Ege University class: OTHER briefSummary: The goal of this clinical trial is to investigate the effects of Reiki, Sham Reiki, and Progressive Relaxation Exercise on the levels of pain, anxiety, and stress in cancer patients.
* At the 3rd month follow-up, pain and anxiety levels (0-10 Likert-type scale), state anxiety scale and perceived stress scale were evaluated. conditions: Therapeutic Touch conditions: Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL interventionModelDescription: This study is a three-arm intervention trial. Reiki was applied to the intervention group, Sham Reiki to the placebo group, and Progressive Relaxation Exercise to the control group. The effects of these three methods applied to cancer patients on their levels of pain, anxiety, and cortisol were examined. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: In order to prevent assessment bias, blinding was implemented throughout the collection of data from patients, evaluation of the effectiveness and reliability of the applied dependent variables, data processing, reporting, and statistical analysis. The researcher was provided with a randomization list by a statistical expert. The researcher was included in the study without knowing which group the patients would be assigned to, and the patients were also enrolled without knowledge of their group assignment. Therefore, this study was conducted as a three-arm, double-blind, randomized follow-up study in the experimental research model, with intervention, placebo, and control groups. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 58 type: ACTUAL name: Reiki name: Sham Reiki name: Progressive Relaxation Exercise measure: Stress levels measure: Anxiety levels measure: Pain levels sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ege University city: İzmir zip: 35100 country: Turkey lat: 38.41273 lon: 27.13838 hasResults: False
nctId: NCT06296667 id: P.T.REC/012/003644 briefTitle: Effect of Core Muscles Training On Patients With Chronic Mechanical Low Back Pain According To SALIBA'S Postural Classification System overallStatus: ACTIVE_NOT_RECRUITING date: 2023-05-01 date: 2024-03-15 date: 2024-04-01 date: 2024-03-06 date: 2024-03-06 name: Cairo University class: OTHER briefSummary: This study is designed as a pre and post experimental study. The purposes of this study are to evaluate the effect of core muscles training in patients with chronic mechanical low back pain according to SALIBA'S postural classification system (SPCS) in terms of pain intensity, function, and core muscles endurance. conditions: Chronic Low-back Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ACTUAL name: core muscles training exercises measure: pain intensity. measure: function disability measure: core muscles endurance measure: participants gender will be male and females, their age in years,their height in meters,weight in kilograms. sex: ALL minimumAge: 20 Years maximumAge: 55 Years stdAges: ADULT facility: Cairo University,Faculty of Physical Therapy city: Giza zip: 11432 country: Egypt lat: 30.00808 lon: 31.21093 hasResults: False
nctId: NCT06296654 id: 25/2021-22 dt. Dec. 12,2021 briefTitle: Effect of Empowerment-Based Interventions on Self-Efficacy and Self-Care Capacity Among Adults With Sickle Cell Disease overallStatus: COMPLETED date: 2022-03-20 date: 2022-10-21 date: 2022-10-22 date: 2024-03-06 date: 2024-03-06 name: University of Bahrain class: OTHER briefSummary: This study aimed to To investigate the effect of empowerment-based interventions (EBI) on self-efficacy and self-care capacity among adults with Sickle Cell Disease (SCD).
The hypotheses of this study were: Adults with SCD who receive EBI exhibit higher self-efficacy, self- management capacity and HRQoL than those who do not. conditions: Self-Efficacy conditions: Self-Care studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: PARTICIPANT count: 68 type: ACTUAL name: Empowerment-Based Interventions name: Standard Health Education measure: Sickle Cell Self-Efficacy measure: Self-Care Capacity sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: College of Health and Sport Sciences, University of Bahrain city: Manama zip: 11511 country: Bahrain lat: 26.22787 lon: 50.58565 hasResults: False
nctId: NCT06296641 id: AAAU9477 briefTitle: Needs Navigation for Caregivers of AYAs acronym: Cope-CAYAC overallStatus: RECRUITING date: 2024-02-16 date: 2025-02 date: 2025-05 date: 2024-03-06 date: 2024-03-06 name: Columbia University class: OTHER briefSummary: The overall aim of the study is to address unmet health-related social needs and reduce outcome disparities among AYA cancer survivors. Aim 1 aimed to refine a needs navigation model in partnership with expert consultants. Aim 2 and 3 will involve the deployment and pilot testing of the adapted needs navigation intervention among caregivers of younger AYAs with cancer. conditions: Cancer in Adolescence studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Participants who screen positive all move forward to receive the intervention primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 60 type: ESTIMATED name: Needs navigation intervention measure: Number of (OR percentage of) participants who completed the intervention measure: Percentage of eligible participants who consented to be in study measure: Personal Financial Wellness Scale (PFWS) / Comprehensive Score of Financial Toxicity (COST measure) sex: ALL minimumAge: 15 Years maximumAge: 26 Years stdAges: CHILD stdAges: ADULT facility: Columbia University Irving Medical Center status: RECRUITING city: New York state: New York zip: 10032 country: United States name: Melissa Beauchemin, PhD, MSN,CPNP-PC, CPO role: CONTACT lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06296628 id: 2000037049 id: 000 type: OTHER domain: CTGTY briefTitle: Rehabilitation Device for Hand Mirror Therapy overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-04 date: 2024-04 date: 2024-03-06 date: 2024-03-06 name: Yale University class: OTHER name: Management Center Innsbruck (MCI), Austria name: Yale School of Engineering Center for Engineering 26 Innovation and Design briefSummary: This study is a randomized and open comparative study that uses two parallel groups: a control group training with conventional therapy and another group that trains with the device "Miraπ". The participants are patients with stroke with motor weakness in one hand. Two measurement visits are required. During those visits, different hand function assessments will be carried out to analyze the motor function of the subjects hand. The measurements will be done during their inpatient rehabilitation stay, one at time of admission and the second at discharge, each taking 20 minutes. In the time between the measurement visits, the hand therapy takes place fivemtimes a week. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants are patients admitted to the acute inpatient rehabilitation unit for rehabilitation of the hand and fingers who have one paralyzed hand without pronounced spasticity. primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: Miraπ name: Mirror Therapy measure: Change in Jebsen-Taylor Hand Function Test score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Yale New Haven Health Inpatient Rehabilitation Unit, Bridgeport Hospital city: Bridgeport state: Connecticut zip: 06610 country: United States lat: 41.16704 lon: -73.20483 hasResults: False
nctId: NCT06296615 id: 2020-022 briefTitle: Whether Vaginal Microbiota Affects Pregnancy Outcomes After Embryo Transfer overallStatus: COMPLETED date: 2021-04-01 date: 2022-10-30 date: 2022-10-30 date: 2024-03-06 date: 2024-03-08 name: ShangHai Ji Ai Genetics & IVF Institute class: OTHER briefSummary: The goal of this observational study is to learn about vaginal microbial characteristics in the patients under in vitro fertilization treatment. The study aims to address the following questions: (1) Is there any difference in microbial composition between the pregnancy and non-pregnancy groups? (2) Is there any differences in specific bacterial species between the two groups? (3) What are the favorable or unfavorable profiles of vaginal microbiota associated with achieving pregnancy? Patients will be asked to complete a questionnaire regarding their basic characteristics, and vaginal secretions will be collected via vaginal swab during frozen-blastocyst transfer procedures. The study will compare vaginal microbiota between pregnant and non-pregnant patients to assess its potential influence on clinical outcomes. conditions: Infertility, Female conditions: Microbial Colonization studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 161 type: ACTUAL measure: Rate of clinical pregnancy sex: FEMALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Shanghai Ji Ai Genetics & IVF Institute city: Shanghai country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06296602 id: 2023/777 briefTitle: Screening Anal HPV Colonization in Men Sex Men Using Pre-exposure Prophylaxis for HIV (ANAPreP'HPV) acronym: ANAPreP'HPV overallStatus: RECRUITING date: 2024-03-04 date: 2024-11-04 date: 2024-11-04 date: 2024-03-06 date: 2024-03-08 name: Centre Hospitalier Universitaire de Besancon class: OTHER briefSummary: This is an interventional study investigating HPV carriage and liquid-based cytology at anal level. It will be offered to all patients undergoing PreP consultations at Besançon University Hospital. The anal swab will be taken by the doctor using a cyto-brush during the consultation. conditions: Pre-Exposure Prophylaxis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: A prelevement for HPV genotyping and anal cytology will be carried out in addition to the anal swabs taken quarterly to screen for other sexually transmitted infections.
A questionnaire will be completed by the doctor to record the data of interest. primaryPurpose: PREVENTION masking: NONE count: 100 type: ESTIMATED name: A prelevement for HPV genotyping and anal cytology will be carried out in addition to the anal swabs taken quarterly to screen for other sexually transmitted infections. measure: prevalence HPV measure: typing HPV measure: High risk HPV risk factors measure: Cytologist abnormalies sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU Besançon status: RECRUITING city: Besancon zip: 25000 country: France name: Cédric LEBRETON, Dr role: CONTACT lat: 47.24878 lon: 6.01815 hasResults: False
nctId: NCT06296589 id: HT94252310861 briefTitle: Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure acronym: PORT overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2027-07 date: 2027-08 date: 2024-03-06 date: 2024-03-06 name: Veterans Medical Research Foundation class: OTHER name: University of Minnesota name: Center for Veterans Research and Education briefSummary: The goal of this clinical trial is to learn if receiving Trauma-Informed Guilt Reduction (TrIGR) Therapy is as effective as receiving Prolonged Exposure Therapy among veterans with PTSD and trauma related guilt. The main questions it aims to answer are:
Will TrIGR be comparable to PE in terms of PTSD symptom reduction? Will it TrIGR be comparable to PE in improving functioning and reducing depression symptoms? Will it be superior in improving trauma-related guilt and shame? conditions: Stress Disorders, Post-Traumatic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 158 type: ESTIMATED name: Trauma Informed Guilt Reduction Therapy name: Prolonged Exposure Therapy measure: Clinician Administered PTSD Scale for DSM-5 (CAPS-5) measure: Patient Health Questionnaire-9 (PHQ-9) measure: Brief Psychosocial Functioning Inventory (B-IPF) measure: Trauma Related Guilt Inventory Cognitions Scale (TRGI) measure: Trauma Related Shame Inventory (TRSI) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Little Rock Veterans Health Care System (LRVHCS) city: Little Rock state: Arkansas zip: 72205 country: United States name: Brandon Griffin role: CONTACT phone: 501-257-1000 email: Brandon.Griffin2@va.gov lat: 34.74648 lon: -92.28959 facility: Southeast Louisiana Veterans Health Care System (SLVHCS) city: New Orleans state: Louisiana zip: 70119 country: United States name: Laurel Franklin, PhD role: CONTACT phone: 800-935-8387 email: Laurel.Franklin@va.gov lat: 29.95465 lon: -90.07507 facility: William S. Middleton Memorial Hospital city: Madison state: Wisconsin zip: 53705 country: United States name: Michael Messina, PhD role: CONTACT phone: 608-284-6302 email: Michael.Messina2@va.gov lat: 43.07305 lon: -89.40123 hasResults: False