hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06281327 id: TX-ITP-001 briefTitle: Avatrombopag in the Treatment of Pediatric Immune Thrombocytopenia overallStatus: RECRUITING date: 2024-03 date: 2025-12 date: 2025-12 date: 2024-02-28 date: 2024-02-28 name: Institute of Hematology & Blood Diseases Hospital, China class: OTHER name: Henan Cancer Hospital name: Tianjin Medical University Second Hospital name: Tianjin Children's Hospital name: The Second Affiliated Hospital of Kunming Medical University briefSummary: To evaluate the safety and efficacy of avatrombopag in the treatment of pediatric primary immune thrombocytopenia in patients who have been treated with eltrombopag before and switched to avatrobopag because of poor efficacy, excessive platelet fluctuation or intolerance, or patient preference, economic reasons, and other reasons. conditions: Immune Thrombocytopenia conditions: Treatment studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Avatrombopag measure: Overall efficacy response after AVA treatment within 12 weeks measure: Treatment response-1 measure: Treatment response-2 measure: Time to Response measure: Persistent response measure: Emergency treatment measure: Reduction of concomitant drug measure: Number of participants with clinically significant bleeding as assessed using the world health organization (WHO) bleeding scale. measure: Number of participants with clinically significant bleeding as assessed using the bleeding scale for pediatric patients with ITP. measure: Health-related quality of life survey of subjects(HRQoL)-1 measure: Health-related quality of life survey of subjects(HRQoL)-2 measure: Health-related quality of life survey of subjects(HRQoL)-3 measure: Health-related quality of life survey of subjects(HRQoL)-4 sex: ALL minimumAge: 6 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College status: RECRUITING city: Tianjin country: China name: Lei Zhang, MD role: CONTACT phone: +8602223909009 email: zhanglei1@ihcams.ac.cn name: Ting Sun, MD role: CONTACT phone: +8602223909009 email: sunting@ihcams.ac.cn lat: 39.14222 lon: 117.17667 hasResults: False
nctId: NCT06281314 id: VESPA 2.0 briefTitle: The Efficacy of VESPA 2.0 for Cognitive Rehabilitation in Patients With Mild Cognitive Impairment overallStatus: COMPLETED date: 2021-03-01 date: 2022-12-27 date: 2023-12-31 date: 2024-02-28 date: 2024-03-08 name: IRCCS Centro Neurolesi "Bonino-Pulejo" class: OTHER briefSummary: VESPA 2.0 is based on an integrative and ecological approach used for the treatment of cognitive dysfunction in patients with MCI or other neurodegenerative disorders. conditions: Neurodegenerative Diseases conditions: Cognitive Decline conditions: Parkinson Disease Dementia conditions: Alzheimer Disease conditions: Multiple Sclerosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ACTUAL name: Vespa software measure: Montreal cognitive assessment (MoCA) sex: ALL minimumAge: 50 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Centro Neurolesi Bonino Pulejo city: Messina state: Sicily zip: 98124 country: Italy lat: 38.19394 lon: 15.55256 hasResults: False
nctId: NCT06281301 id: HSC-MS-23-1023 briefTitle: Improving Patient Understanding of Macrosomia overallStatus: RECRUITING date: 2024-01-30 date: 2024-04-30 date: 2024-09-01 date: 2024-02-28 date: 2024-02-28 name: The University of Texas Health Science Center, Houston class: OTHER briefSummary: The purpose of this study is to evaluate the effectiveness of a graphic based education tool on patient knowledge of macrosomia through the use of a survey and to evaluate knowledge at 1-2 weeks after initial review of the education tool. conditions: Macrosomia, Fetal studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 176 type: ESTIMATED name: education tool name: no additional information measure: Number of participants that showed Macrosomia knowledge greater than 50 percent as assessed by the score on a survey sex: FEMALE minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: The University of Texas Health Science Center at Houston status: RECRUITING city: Houston state: Texas zip: 77030 country: United States name: Kristen Cagino, MD role: CONTACT phone: 713-500-6412 email: Kristen.A.Cagino@uth.tmc.edu name: Suneet Chauhan role: CONTACT email: mfmchauhan@gmail.com lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06281288 id: P.T.REC/012/004754 briefTitle: Cognitive-Behavioral Therapy With Exercise Training in Adolescent Females With Elevated Depression Symptoms overallStatus: ENROLLING_BY_INVITATION date: 2023-12-25 date: 2024-03 date: 2024-03 date: 2024-02-28 date: 2024-03-19 name: Doaa Tammam Atia class: OTHER briefSummary: PURPOSE: To Study the Effect of Cognitive-behavioral therapy combined with exercise training in adolescent females with elevated depression symptoms
BACKGROUND: Teenagers are more likely than any other age group to experience psychological issues due to depression, Adolescents have gotten active attention from society for their mental health difficulties since they are a high-level reserve talent stratum in society. Adolescent depression rates have increased in recent years, and "silent killers" are preying on them. Teenagers are more likely than any other age group to experience psychological issues due to depression, Adolescents have gotten active attention from society for their mental health difficulties since they are a high-level reserve talent stratum in society. Adolescent depression rates have increased in recent years, and "silent killers"
RESEARCH QUESTION: Is there is an effect of exercise on depression in adolescent girls. conditions: Depression studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Cognitive-Behavioral Therapy name: Exercise Training measure: Center for Epidemiological Studies Depression Scale for Children (CES-DC), sex: FEMALE minimumAge: 12 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: doaa Tammam Atia city: Suez country: Egypt lat: 29.97371 lon: 32.52627 hasResults: False
nctId: NCT06281275 id: TJ-IRB202402008 briefTitle: A Study of the Association Between Frailty and Acute Postoperative Pain in Elderly Thoracoscopic Surgery Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-12 date: 2024-09-30 date: 2024-10-30 date: 2024-02-28 date: 2024-04-12 name: Huazhong University of Science and Technology class: OTHER briefSummary: To gain a clearer understanding of the association between frailty and postoperative acute pain in elderly thoracoscopic surgery patients and its underlying mechanisms, to provide new solution ideas to reduce the level of postoperative acute pain and improve the debilitating state of elderly thoracoscopic surgery patients, and consequently improve their quality of life and mental status. conditions: Frailty conditions: Acute Postoperative Pain studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 78 type: ESTIMATED measure: All patients' Numerical Rating Scale （NRS） scores for most significant pain at rest in the 48h postoperative period measure: Numerical Rating Scale （NRS） scores for the most pronounced pain in the patient's coughing state in the 48h postoperative period measure: PCA pump consumption measure: Number of PCA pump presses sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology city: Wuhan state: Hubei zip: 430030 country: China lat: 30.58333 lon: 114.26667 hasResults: False
nctId: NCT06281262 id: GIP-23-L-04-223 briefTitle: Selected Immunological Indicators and Microbiota in Patients With Premature Birth and Preeclampsia acronym: PRIME overallStatus: RECRUITING date: 2023-06-30 date: 2025-03-30 date: 2025-03-30 date: 2024-02-28 date: 2024-03-01 name: General University Hospital, Prague class: OTHER name: Charles University, Czech Republic name: Institute of Hematology and Blood Transfusion, Czech Republic briefSummary: The goal is to demonstrate the relationship of the circulating pool of T-regulatory lymphocytes in the mother's peripheral blood with populations in the placentas and to compare with controls, what is the difference in the expression of individual regulatory molecules of T-regulatory lymphocytes according to new paradigms. The proportional and functional characteristics of T-regulatory lymphocytes will be correlated with the composition of the intestinal and vaginal microbiota. conditions: Preterm Birth conditions: Preeclampsia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Peripheral blood collection name: Swab sample collection measure: Changes in selected T cell subpopulations in the first trimester associated with subsequent spontaneous preterm birth measure: Changes in selected T cell subpopulations in the first trimester associated with subsequent pre-eclampsia measure: Association of maternal microbiota and maternal T regulatory cell populations. sex: FEMALE minimumAge: 19 Years maximumAge: 40 Years stdAges: ADULT facility: Department of Gynaecology, Obstetrics and Neonatology of the First Faculty of Medicine of the Charles University and General University Hospital in Prague status: RECRUITING city: Prague zip: 128 08 country: Czechia name: Zdeněk Laštůvka, MUDr., Ph.D. role: CONTACT phone: +420777724640 email: zdenek.lastuvka@vfn.cz name: Michal Koucký, Doc., MUDr., Ph.D. role: CONTACT phone: +420603219916 email: michal.koucky@vfn.cz lat: 50.08804 lon: 14.42076 hasResults: False
nctId: NCT06281249 id: 73172 briefTitle: Neuraxial Ultrasound Device Study overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-03 date: 2025-03 date: 2024-02-28 date: 2024-03-15 name: Stanford University class: OTHER name: Rivanna Medical, Inc. briefSummary: The aim of the study is to develop a device that can eliminate failed neuraxial placements in challenging patients.The study will attempt to improve safety and efficacy of neuraxial anesthesia with high precision real-time needle visualization through automated real-time needle guidance at the bedside with an experimental device (Accuro 3S). Investigators will verify the clinical workflow for utilizing the Accuro 3S during epidural and spinal procedures and validation of needle visualization while using the device as well as anatomical guidance provided by the device during spinal imaging.The underlying bone imaging enhancement algorithms were introduced in the commercially available FDA approved Accuro. The Accuro 3S will be used to establish needle insertion point and trajectory, after which the clinician will use standard of care methods to advance the needle such as the loss of resistance method. conditions: Labor Pain conditions: Cesarean Delivery Regional Anesthesia Induction studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Ultrasound placement device measure: Incidence of difficult block placement measure: Incidence of failed block measure: Incidence of post-dural puncture headache sex: FEMALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Stanford University city: Stanford state: California zip: 94305 country: United States lat: 37.42411 lon: -122.16608 hasResults: False
nctId: NCT06281236 id: SPI-62-CL-1002 briefTitle: A Trial of Prednisolone in Combination With SPI-62 in Participants With Polymyalgia Rheumatica (PMR) overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-10-01 date: 2024-10-01 date: 2024-02-28 date: 2024-02-28 name: Sparrow Pharmaceuticals class: INDUSTRY briefSummary: This will be an open label phase 1b trial to characterize the pharmacodynamics and PK of prednisolone and SPI-62 when co-administered to participants with PMR. Up to 24 participants could be recruited. conditions: Polymyalgia Rheumatica studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 24 type: ESTIMATED name: Prednisolone name: SPI-62 measure: Erythrocyte sedimentation rate measure: C-reactive protein measure: Plasma fibrinogen sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Emovis Gmbh city: Berlin country: Germany name: Anna Wieczorek role: CONTACT phone: +49 30 439741221 email: anna.wieczorek@futuremeds.com name: Frank Zollmann role: PRINCIPAL_INVESTIGATOR lat: 52.52437 lon: 13.41053 facility: Klinische Forschung Hannover Mitte GmbH/Pratia city: Hannover zip: 30159 country: Germany name: Matilde Planer role: CONTACT phone: +49 511 169 7650 email: matilde.planer@pratia.com name: Jan Wagner role: PRINCIPAL_INVESTIGATOR lat: 52.37052 lon: 9.73322 facility: Klinische Forschung Schwerin GmbH/Pratia city: Schwerin zip: 19055 country: Germany name: Julia Grindel role: CONTACT phone: +49 385 557 740 email: julia.grindel@pratia.com name: Charlotte von Engelhardt role: PRINCIPAL_INVESTIGATOR lat: 53.62937 lon: 11.41316 hasResults: False
nctId: NCT06281223 id: JBR_2023_9 briefTitle: Study of Brain-spinal Cord Neural Connectivity in Spasticity acronym: MOVE overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-05 date: 2026-05 date: 2024-02-28 date: 2024-02-28 name: Fondation Ophtalmologique Adolphe de Rothschild class: NETWORK briefSummary: Little is known about the peripheral and central mechanisms of action of selective dorsal rhizotomy surgery for the treatment of spasticity. A better understanding of these mechanisms will enable us to improve the surgical procedure. This will require cortico-medullo-radiculo-muscular recordings never before performed and published in the literature, and the identification of variations in connectivity correlated with the clinic. conditions: Spasticity, Muscle studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: intraoperative neuroelectrophysiological monitoring measure: variation in "spontaneous/resting" cortico-medullo-radiculo-muscular synchronization before and after selective rhizotomy surgery sex: ALL minimumAge: 3 Years maximumAge: 17 Years stdAges: CHILD hasResults: False
nctId: NCT06281210 id: IEO 2034 briefTitle: Vabb After Neoadjuvant Therapy to Avoid Surgery-pCR to Avoid Breast Surgery acronym: BETTY-CRASY overallStatus: RECRUITING date: 2023-12-11 date: 2028-12-31 date: 2028-12-31 date: 2024-02-28 date: 2024-02-28 name: European Institute of Oncology class: OTHER briefSummary: This single arm study aims to evaluate the efficacy and safety of a non-surgical approach, consisting of radiotherapy (RT) alone, for patients who have achieved a complete pathological response (pCR) following neoadjuvant chemotherapy (NACT). The study design involves the histological confirmation of pCR using vacuum-assisted biopsy (VABB) or vacuum-assisted excision (VAE) guided by ultrasound. The primary objective is to demonstrate that the non-surgical, RT-only treatment and follow-up approach is not inferior to the traditional surgical approach in patients with pCR after NACT. conditions: Breast Cancer conditions: Triple Negative Breast Cancer conditions: HER2-positive Breast Cancer conditions: Neoadjuvant Chemotherapy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 77 type: ESTIMATED name: Omission of surgical treatment measure: Event-free survival measure: Positive predictive value of MRI measure: Contrast-Enhanced Mammography (CEM) positive predictive value sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istituto di Candiolo IRCCS status: NOT_YET_RECRUITING city: Candiolo state: Turin zip: 10060 country: Italy name: Antonio Toesca, MD role: CONTACT lat: 44.95858 lon: 7.59812 facility: European Institute of Oncology status: RECRUITING city: Milan zip: 20141 country: Italy name: Elisabetta Rossi, MD role: CONTACT phone: +390294372191 email: ElisabettaMariaCristina.Rossi@ieo.it name: Mara Negri role: CONTACT email: mara.negri@ieo.it name: Elisabetta Rossi, MD role: PRINCIPAL_INVESTIGATOR lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06281197 id: 2021/48 briefTitle: Does Subspinal Le Fort I Osteotomy Affect the Nasal Airway Volume overallStatus: COMPLETED date: 2021-01-15 date: 2021-08-15 date: 2022-05-15 date: 2024-02-28 date: 2024-02-28 name: TC Erciyes University class: OTHER briefSummary: After the description of Le Fort fractures, maxillary osteotomies are used to correct dentofacial deformities. The profile changes on nasolabial region resulting from a Le Fort I osteotomy, also that affects nasal airway. The Subspinal Le Fort I osteotomy (SLFIO) describe to prevent undesirable soft tissue changes. In the literature, too many articles have reported the effectiveness of SLFIO in preventing nasal deformation. However, there is no study to evaluate the nasal volume or septum deviation. conditions: Maxillofacial Abnormalities studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: double blind primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: double blind whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 47 type: ACTUAL name: Conventional name: Subspinal measure: Evaluation of Septum Deviation measure: Evaluation of Nasal Airway measure: nasal obstruction scale evaluation sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Selin Çelebi city: Kayseri state: Meligazi zip: 38320 country: Turkey lat: 38.73222 lon: 35.48528 hasResults: False
nctId: NCT06281184 id: DIA2024.1 id: 715758 type: REGISTRY domain: Regional committee for medical and health research ethics briefTitle: A Post-trial Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate Treatment in Adults With Erosive Hand OA. acronym: MERINO:2 overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2027-02-01 date: 2027-02-01 date: 2024-02-28 date: 2024-02-28 name: Diakonhjemmet Hospital class: OTHER briefSummary: In response to the high prevalence of synovitis in hand osteoarthritis (OA) and its association with pain, there\&#39;s a compelling rationale for investigating the efficacy of MTX in managing inflammatory erosive hand OA. Recent guidelines highlight the need for large, well-designed trials to assess the effectiveness of MTX. A recent trial (METHODS study) showed promising pain reduction with MTX, but due to pandemic-related protocol changes, the duration of the study was limited to six months. The ongoing MERINO trial randomizes participants to MTX or placebo for one year. After completing the MERINO trial, several participants asked for MTX open label. In the subsequent MERINO:2 study, participants completing the trial will be invited to a structured follow-up after one year, including electronic questionnaires and hand radiographs, providing valuable long-term data on the effects of MTX in hand OA. Together, these trials aim to fill gaps in understanding the long-term impact of MTX in hand OA, particularly on structural progression. conditions: Hand Osteoarthritis conditions: Erosive Osteoarthritis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 108 type: ESTIMATED name: Methotrexate name: No treatment measure: Effect of MTX on radiographic progression of erosive hand OA. measure: Effect of MTX on pain, function and life quality measure: Effect of MTX on radiographic progression of hand OA. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Diakonhjemmet Hospital city: Oslo zip: 0319 country: Norway name: Ida Løchting role: CONTACT phone: +4722451500 email: Ida.Lochting@diakonsyk.no name: Alexander Mathiessen, MD PhD role: PRINCIPAL_INVESTIGATOR lat: 59.91273 lon: 10.74609 hasResults: False
nctId: NCT06281171 id: 90BISB0022 briefTitle: Evaluation of SkillTalk for Autistic Young Adults overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-01 date: 2024-07-31 date: 2024-08-31 date: 2024-02-28 date: 2024-04-17 name: dfusion Inc class: INDUSTRY briefSummary: The goal of this clinical trial is to evaluate the effectiveness of using a Microskills video training library for young adults, aged 18-28, with autism spectrum disorder (ASD) to enhance their skills in developing and maintaining healthy relationships.
* Watch a minimum of 85% of the 60 minutes of video assigned conditions: Autism Spectrum Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 110 type: ESTIMATED name: SkillTalk for Autistic Young Adults name: Flyer Library measure: Demonstrated Skill Score in communication skills. measure: Participant Confidence & Satisfaction in their communication skills measure: Interpersonal Competence Score measure: Coping with Rejection, Jealousy and Relationship Anxiety measure: Mental Health and Wellbeing sex: ALL minimumAge: 18 Years maximumAge: 28 Years stdAges: ADULT facility: Virtual Study city: Santa Cruz state: California zip: 95060 country: United States lat: 36.97412 lon: -122.0308 hasResults: False
nctId: NCT06281158 id: DNLI-F-0009 briefTitle: A Phase 1, Open-label Study of the Absorption, Metabolism, and Excretion of [14C]-DNL343 Following a Single Oral Dose in Healthy Male Participants overallStatus: RECRUITING date: 2024-03 date: 2024-05 date: 2024-05 date: 2024-02-28 date: 2024-03-01 name: Denali Therapeutics Inc. class: INDUSTRY briefSummary: This is a Phase 1, open-label, nonrandomized, single-dose study in healthy male participants to investigate the absorption, metabolism and excretion of DNL343. conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 7 type: ESTIMATED name: [14C]-DNL343 measure: PK Parameter: AUC0-∞ measure: PK Parameter: AUC0-tlast measure: PK Parameter: Cmax measure: PK Parameter: Tmax measure: PK Parameter: t1/2 measure: Total radioactivity in plasma and whole blood measure: Total radioactivity in blood-to-plasma ratio measure: Extent and rate of recovery of total radioactivity in urine and feces measure: PK Parameter: AUC0-∞ measure: PK Parameter: AUC0-tlast measure: PK Parameter: Cmax measure: PK Parameter: Tmax measure: PK Parameter: t1/2 measure: DNL343 and a DNL343 metabolite recoveries in urine measure: Incidence, severity, and seriousness of treatment-emergent adverse events (TEAEs) sex: MALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clinical Site status: RECRUITING city: Madison state: Wisconsin zip: 53704 country: United States lat: 43.07305 lon: -89.40123 hasResults: False