Participants receive treatment and will complete questionnaires. The study is conducted in two phases. Its aim is to compare two different trauma-focused treatments (EMDR and PE) for patients with PTSD to one another and with a nontrauma-focused psychotherapy (IPT) and to investigate possible predictors and moderators for treatment success. Patients will first be randomized to PE or EMDR in the first treatment phase. After this first phase, non-responders are re-randomized for a second phase of treatment. They receive either the alternative phase 1 trauma-focused psychotherapy or IPT as non-trauma-focused therapy. In phase 1 researchers will compare the PE and EMDR group to see which treatment is most effective for whom. In phase 2 researchers will compare the trauma-focused treatments (PE and EMDR group) with the nontrauma-focused treatment (IPT group) to see which treatment is most effective for whom. conditions: Stress Disorders, Post-Traumatic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study is a randomized controlled trial (RCT) conducted in two phases. Patients with PTSD will first be randomized to PE or EMDR in the first treatment phase. After this first phase of treatment, non-responders are re-randomized for a second phase of treatment. They receive either the alternative phase 1 trauma-focused psychotherapy or IPT as non-trauma-focused therapy for PTSD. In both phases (phase 1 and 2) the treatment lasts 8 weeks. Patients receive 14 sessions of 1 hour in 8 weeks. primaryPurpose: TREATMENT masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 442 type: ESTIMATED name: Prolonged Exposure therapy name: Eye Movement Desensitization Reprocessing (EMDR) name: Interpersonal Psychotherapy (IPT) measure: PTSD Checklist for DSM-5 (PCL-5) measure: Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) measure: International Trauma Questionnaire (ITQ) measure: Hospital Anxiety and Depression Scale (HADS) measure: Mental Health Continuum Short Form (MHC-SF) measure: Positive and Negative Experiences of Psychotherapy questionnaire (PNEP) measure: Age measure: Gender measure: Education measure: Employment measure: Marital status measure: Ethnicity/race measure: Medication use measure: Treatment history measure: Mini-Schedules for Clinical Assessment in Neuropsychiatry (mini-SCAN) measure: Life Events Checklist for DSM-5 (LEC-5) measure: The Childhood Trauma Questionnaire-Short Form (CTQ-SF) measure: Symptom Checklist-90 (SCL-90), Hostility subscale measure: Experiences in Close Relationships-Relationship Structures (ECR-RS) measure: The Brief Experiental Avoidance Questionnaire (BEAQ) measure: Improving Access to Psychological Therapies (IAPT) measure: Posttraumatic Cognitions Inventory (PTCI) measure: Trauma Related Guilt Inventory (TRGI) measure: Trauma Related Shame Iventory (TRSI) measure: Working Alliance Questionnaire shortened version (WAV-12) measure: Expectancy rating (patients and therapists) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Dimence status: RECRUITING city: Deventer country: Netherlands name: Maarten K van Dijk, PhD role: CONTACT phone: +31 0570-604000 email: m.vandijk@dimence.nl name: Dominique Jonkers, Master role: CONTACT phone: +31 038-4692300 email: d.jonkers@dimence.nl lat: 52.255 lon: 6.16389 hasResults: False