nctId: NCT06275360 id: SPLP-002-23F briefTitle: Repositioning Immunotherapy in VetArans With Lung Cancer acronym: RIVAL overallStatus: RECRUITING date: 2024-03-01 date: 2027-02-28 date: 2030-03-31 date: 2024-02-23 date: 2024-03-12 name: VA Office of Research and Development class: FED briefSummary: This study is a multicenter Phase II single arm trial to assess the safety and efficacy of chemotherapy and immunotherapy followed by radiotherapy in patients with unresectable Stage III NSCLC. conditions: Non-Small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Carboplatin, paclitaxel, and nivolumab for three cycles followed by radiotherapy followed by nivolumab (for squamous cell lung cancer) OR Carboplatin, pemetrexed, and nivolumab for three cycles followed by radiotherapy followed by nivolumab (for lung adenocarcinoma) primaryPurpose: TREATMENT masking: NONE count: 25 type: ESTIMATED name: Nivolumab measure: Progression-free survival measure: Treatment Tolerance measure: Adverse Events measure: Best overall response rate (BOR) measure: Overall survival sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: VA Greater Los Angeles Healthcare System, West Los Angeles, CA status: NOT_YET_RECRUITING city: West Los Angeles state: California zip: 90073-1003 country: United States name: Daniel Shin, MD role: CONTACT phone: 310-478-3711 email: Daniel.Shin@va.gov name: Michelle Treadwell role: CONTACT phone: 3104783711 phoneExt: 45003 email: Michelle.Treadwell@va.gov lat: 34.0464 lon: -118.44813 facility: VA Connecticut Healthcare System West Haven Campus, West Haven, CT status: RECRUITING city: West Haven state: Connecticut zip: 06516-2770 country: United States name: Michal Rose, MD role: CONTACT phone: 203-932-5711 phoneExt: 2832 email: Michal.Rose@va.gov name: Alicia Roy role: CONTACT phone: 2039325711 phoneExt: 3006 email: Alicia.Roy@va.gov lat: 41.27065 lon: -72.94705 facility: VA Ann Arbor Healthcare System, Ann Arbor, MI status: RECRUITING city: Ann Arbor state: Michigan zip: 48105-2303 country: United States name: Brittany M Pannecouk, BS role: CONTACT phone: 734-845-3966 email: brittany.pannecouk@va.gov name: Laura A Randolph, BA role: CONTACT phone: (734) 845-5091 email: Laura.Randolph@va.gov name: Michael D Green role: PRINCIPAL_INVESTIGATOR name: Nithya Ramnath, MD role: PRINCIPAL_INVESTIGATOR lat: 42.27756 lon: -83.74088 facility: Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE status: NOT_YET_RECRUITING city: Omaha state: Nebraska zip: 68105-1850 country: United States name: Apar Kishor P Ganti, MD role: CONTACT phone: 402-346-8800 phoneExt: 3846 email: Aparkishor.Ganti@va.gov name: Anna Kellogg role: CONTACT phone: 4029954143 email: Anna.Kellogg@va.gov lat: 41.25626 lon: -95.94043 facility: Durham VA Medical Center, Durham, NC status: NOT_YET_RECRUITING city: Durham state: North Carolina zip: 27705-3875 country: United States name: Michael Kelley, MD role: CONTACT phone: 919-286-0411 phoneExt: 172199 email: Michael.Kelley6@va.gov name: Maya Robinson role: CONTACT phone: 9192866926 email: Maya.Robinson@va.gov lat: 35.99403 lon: -78.89862 facility: Louis Stokes VA Medical Center, Cleveland, OH status: NOT_YET_RECRUITING city: Cleveland state: Ohio zip: 44106-1702 country: United States name: Charles Nock, MD role: CONTACT phone: 216-791-3800 phoneExt: 64825 email: Charles.Nock@va.gov name: Margaret Titkin role: CONTACT phone: 2167913800 phoneExt: 36241 email: MargaretTiktin@va.gov lat: 41.4995 lon: -81.69541 facility: Hunter Holmes McGuire VA Medical Center, Richmond, VA status: NOT_YET_RECRUITING city: Richmond state: Virginia zip: 23249-0001 country: United States name: Bhaumik Patel, MD role: CONTACT phone: 804-675-5446 email: Bhaumik.Patel@va.gov lat: 37.55376 lon: -77.46026 hasResults: False