nctId: NCT06341582 id: 2023-10-14 briefTitle: Prediction and Evaluation by ETCOc of Neonatal Hyperbilirubinemia Cohort acronym: PREVENT overallStatus: RECRUITING date: 2023-12-11 date: 2025-11 date: 2025-11 date: 2024-04-02 date: 2024-04-02 name: Guangzhou Women and Children's Medical Center class: OTHER briefSummary: The hemolytic disease of newborns (HDN) is one of the most significant risk factors for hyperbilirubinemia. Studies have shown that end-tidal carbon monoxide-corrected (ETCOc) correlated with the rate of bilirubin production in the body and thus can be a good surrogate to quantify hemolysis and identifying the high-risk infants. However, there is insufficient clinical evidence regarding the early prediction of hemolytic hyperbilirubinemia using ETCOc. This study hypothesizes that early postnatal ETCOc levels are significantly associated with the risk of hemolytic hyperbilirubinemia requiring treatments within 14 days after birth, and early postnatal ETCOc can be a good indicator for early prediction of hemolysis. In addition, the investigators aim to investigate the relationship between the characteristics of treatments for hyperbilirubinemia and ETCOc. conditions: Neonatal Jaundice conditions: Neonatal Hyperbilirubinemia conditions: Hemolysis Neonatal studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2700 type: ESTIMATED name: End-tidal carbon monoxide-corrected (ETCOc) measure: The incidence of hemolytic hyperbilirubinemia within 14 days of life (DOL) measure: The incidence of neonatal hyperbilirubinemia within 14 days of life (DOL) measure: The incidence of hemolytic diseases of newborns within 14 days of life (DOL) measure: The rate of readmission due to neonatal hyperbilirubinemia within 28 days of life (DOL) sex: ALL minimumAge: 1 Hour maximumAge: 72 Hours stdAges: CHILD facility: Dongguan Maternity and Child Healthcare Hospital status: NOT_YET_RECRUITING city: Dongguan state: Guangdong zip: 523700 country: China name: Minxu Li, M.D. role: PRINCIPAL_INVESTIGATOR lat: 23.01797 lon: 113.74866 facility: Foshan Shunde Women and Children Health Care Hospital status: NOT_YET_RECRUITING city: Foshan state: Guangdong zip: 528300 country: China name: Runzhong Huang, M.D. role: PRINCIPAL_INVESTIGATOR lat: 23.02677 lon: 113.13148 facility: Guangdong Maternity and Child Healthcare Hospital status: NOT_YET_RECRUITING city: Guangzhou state: Guangdong zip: 510010 country: China name: Chuan Nie, M.D. role: PRINCIPAL_INVESTIGATOR lat: 23.11667 lon: 113.25 facility: The First affiliated Hospital, Sun Yat-sen University status: NOT_YET_RECRUITING city: Guangzhou state: Guangdong zip: 510080 country: China name: Muxue Yu, M.D. role: PRINCIPAL_INVESTIGATOR lat: 23.11667 lon: 113.25 facility: Guangzhou Women and Children's Medical Center status: RECRUITING city: Guangzhou state: Guangdong zip: 510623 country: China name: Ge Yang, M.D. role: CONTACT phone: (86)020-38076329 email: geyang99@outlook.com name: Huayan Zhang, M.D. role: PRINCIPAL_INVESTIGATOR lat: 23.11667 lon: 113.25 facility: The First Affiliated Hospital of Jinan University, Guangzhou Overseas Chinese Hospital status: NOT_YET_RECRUITING city: Guangzhou state: Guangdong zip: 510632 country: China name: Bingxiao Li, M.D. role: PRINCIPAL_INVESTIGATOR name: Shasha Han, M.D. role: PRINCIPAL_INVESTIGATOR lat: 23.11667 lon: 113.25 facility: Shenzhen Maternity and Child Healthcare Hospital status: NOT_YET_RECRUITING city: Shenzhen state: Guangdong zip: 518000 country: China name: Chuanzhong Yang, M.D. role: PRINCIPAL_INVESTIGATOR lat: 22.54554 lon: 114.0683 hasResults: False