hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06314633 id: ICO-2023-13 briefTitle: Socioeconomic Determinants of the Chemical Exposome and Its Genotoxic Effects in Children acronym: PESTIFOL overallStatus: RECRUITING date: 2024-01-29 date: 2026-01 date: 2026-06 date: 2024-03-18 date: 2024-03-21 name: Institut Cancerologie de l'Ouest class: OTHER name: ANSES briefSummary: PESTIFOL will include children over 8 and under 12 years old of different socioeconomic positions (SEP), mostly living in the region of Pays de la Loire. This approach should enable us to assess the impact of the SEP, and therefore social inequalities, on chemical expositions and DNA damage, and to characterize which (classes/mixture of) pollutants are major source of DNA damage. The study will also address potential effects associated with geographical location on the exposome and its biological consequences. conditions: Healthy Volunteer Children studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Hair collection and parents questionnaires primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 140 type: ESTIMATED name: Hair cut name: Socio-economic questionnaires measure: Describe DNA damage measure: Describe DNA damage measure: Describe socio-economic characteristics. measure: Describe socio-economic characteristics. measure: Characterize chemical exposome variations measure: Characterize chemical exposome variations measure: Characterize socio-economic indicators measure: Characterize socio-economic indicators, geographical area, seasons measure: Characterize socio-economic indicators, geographical area, seasons measure: Characterize socio-economic indicators, geographical area, seasons measure: Describe DNA damage measure: Describe DNA damage sex: ALL minimumAge: 8 Years maximumAge: 12 Years stdAges: CHILD facility: Institut de Cancérologie de l'ouest status: RECRUITING city: Saint-Herblain zip: 44800 country: France name: Marie ROBERT, MD role: CONTACT email: Marie.Robert@ico.unicancer.fr name: Pierre VIDI, PhD role: CONTACT email: Pierre.Vidi@ico.unicancer.fr name: Marie ROBERT, MD role: PRINCIPAL_INVESTIGATOR name: PIERRE VIDI, PhD role: SUB_INVESTIGATOR name: Martine BELLANGER, PhD role: SUB_INVESTIGATOR lat: 47.21765 lon: -1.64841 hasResults: False
nctId: NCT06314620 id: FF-2024-043 briefTitle: Normal Saline Flushing With And Without Heparin Lock In Maintaining Small Bore Intercostal Chest Catheter (ICC) Patency acronym: SENSHIP overallStatus: RECRUITING date: 2024-03-15 date: 2027-03-01 date: 2027-06-01 date: 2024-03-18 date: 2024-03-26 name: National University of Malaysia class: OTHER briefSummary: Pleural diseases are among the most common clinical problems encountered in healthcare settings in Malaysia and even worldwide. Most patients presented in a hospital setting with pleural diseases will need pleural aspirations or thoracentesis and chest drains for a variety of reasons. Healthcare providers will often be exposed to patients requiring pleural drainage hence it is important to be aware of safe techniques and procedures of insertion and also maintaining the pleural drainage systems to yield beneficial results.
Most often, smaller catheters were deemed to be less effective in view of slower drainage rates and associated with high risk of blockage. However presently , in tertiary hospital settings small bore intercostal chest catheters (SBICC) have become an alternative to large bore intercostal catheters (LBICC). SBICC has been found to be equally effective, less painful and easily tolerated by patients. Hence, proper maintenance of SBICC should be undertaken to reduce rates of occlusion and to yield most benefits from the pleural aspirations procedures.
There is limited data comparing the use of normal saline flushing versus fibrinolytic drug lock in maintaining patency of small bore intercostal chest drains in draining pleural effusions. This has lead us in conducting this research to compare the rates of partial or complete occlusions among normal saline flush with and without heparin saline lock in maintaining the patency of small bore intercostal chest catheter among patients with pleural diseases in Hospital Canselor Tuanku Muhriz, UKM requiring chest drains insertion. conditions: Pleural Effusion studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 40 type: ESTIMATED name: Heparin saline lock name: Without heparin saline lock measure: To compare the rate (in percentage) of occlusions of intercostal chest catheter in participants underwent normal saline flushing with and without heparin lock measure: To determine the onset of intercostal chest catheter occlusions (in hours) measure: To determine the change of hemoglobin (in g/dL) post ICC insertion measure: To determine the change of platelet (in 10 9/L) post ICC insertion measure: To determine the adverse effects of heparin saline lock measure: To assess the number of fenestrations occluded (in numbers from 0-5) with fibrin or blood clots sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: National University of Malaysia status: RECRUITING city: Kuala Lumpur state: Wilayah Persekutuan zip: 53300 country: Malaysia name: Mohamed Faisal Abdul Hamid role: CONTACT phone: 0391455555 phoneExt: 6082 email: faisal.hamid@ppukm.ukm.edu.my lat: 3.1412 lon: 101.68653 typeAbbrev: Prot_SAP_ICF hasProtocol: True hasSap: True hasIcf: True label: Study Protocol, Statistical Analysis Plan, and Informed Consent Form date: 2024-02-17 uploadDate: 2024-03-13T04:03 filename: Prot_SAP_ICF_000.pdf size: 521443 hasResults: False
nctId: NCT06314607 id: APHP220498 briefTitle: Genetic and Molecular Characterization of Nervous System Lesions acronym: ONCONEUROTEK 2 overallStatus: RECRUITING date: 2024-03-26 date: 2034-03 date: 2034-03 date: 2024-03-18 date: 2024-04-29 name: Assistance Publique - Hôpitaux de Paris class: OTHER briefSummary: Primary and secondary brain tumors, the leading cause of death from cancer before the age of 35, represent a complex and heterogeneous group of pathologies with a generally poor prognosis. Knowledge of these tumors has made enormous strides thanks to access to biological samples, leading to a much more robust, reliable and precise histo-pronostic classification, but also, increasingly, to the identification of theranostic targets.
This project aims to make a decisive contribution to these objectives. conditions: Brain Tumor conditions: Brain Lesion (General) studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 10000 type: ESTIMATED name: Prospective Biological Collection name: Retrospective Biological Collection measure: Study the clinical markers with the evolution of brain lesions. measure: Study the biological markers with the evolution of brain lesions. measure: Study the anatomopathological markers with the evolution of brain lesions. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Service de Neurochirurgie - Hôpital de la Pitié Salpêtrière status: RECRUITING city: Paris zip: 75013 country: France name: Bertand Mathon, Dr role: CONTACT phone: 01 84 82 73 63 phoneExt: +33 email: bertrand.mathon@aphp.fr lat: 48.85341 lon: 2.3488 facility: Service de Neurologie 2 -Hôpital de la Pitié Salpêtrière status: RECRUITING city: Paris zip: 75013 country: France name: Marc Sanson, Prof role: CONTACT phone: 01 42 16 03 91 phoneExt: +33 email: marc.sanson@aphp.fr lat: 48.85341 lon: 2.3488 facility: Service de Radiothérapie - Hôpital de la Pittié Salpêtrière status: NOT_YET_RECRUITING city: Paris zip: 75013 country: France name: Julian Jacob, Dr role: CONTACT phone: 01 84 82 74 90 phoneExt: +33 email: julian.jacob@aphp.fr lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06314594 id: 2024KY920 briefTitle: the Individualized Stepwise Treatment Mode of Adolescent Idiopathic Scoliosis overallStatus: RECRUITING date: 2023-12-20 date: 2025-12-01 date: 2026-12-01 date: 2024-03-18 date: 2024-03-18 name: Hangzhou Medical College class: OTHER briefSummary: Based on the risk factors affecting adolescent scoliosis found in the previous social survey, this project adopts the paradigm based on transfer learning and semi-supervised learning, and uses mathematical methods such as multiple learning methods and Transformer image classification algorithms to develop and verify the early warning model and stepped treatment model of adolescent scoliosis, and conducts cost-effect analysis. conditions: Adolescent Scoliosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 76 type: ESTIMATED name: Conventional treatment name: intervention treatment measure: Number of Cobb angles measure: Accuracy of new screening modalities measure: Hamilton Depression Volume sex: ALL minimumAge: 3 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: the Affiliated Zhejiang Provincial People's Hospital to Hangzhou Medical College. status: RECRUITING city: Hangzhou state: Zhejiang zip: 311000 country: China name: Xinyun Dr LI, Doctor role: CONTACT phone: 8618069783240 email: lxyjasmine2010@163.com lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06314581 id: 673_BPPV-Teaching briefTitle: Effect of a Multifaceted Educational Intervention on the Implementation of Evidence-based Practices for Benign Paroxysmal Positional Vertigo in an Emergency Department acronym: BPPV-Teaching overallStatus: RECRUITING date: 2023-05-01 date: 2024-05-01 date: 2024-12-01 date: 2024-03-18 date: 2024-03-18 name: Fondation Hôpital Saint-Joseph class: OTHER briefSummary: Acute vertigo accounts for around 4% of emergency room visits. Triggered episodic vestibular syndrome is the most commonly encountered symptomatic context. BPPV (Benign Paroxysmal Positional Vertigo) is the main cause, representing 40-50% of the vertigo cases assessed in emergency departments. It results from the migration of calcium carbonate particles (otoliths), from the sticky membrane of the utricle and saccule of the inner ear, to one of the 3 semicircular canals (SCC), posterior, horizontal or lateral, and anterior. It occurs idiopathically with head movement, through degeneration, or following head trauma. The otolith impulse causes the endolymph to move, temporarily and aberrantly displacing the cup of the affected canal, resulting in the transmission of erroneous information to the vestibular nuclei. This leads to the sudden onset of vertigo and eye deviation, resulting in transient nystagmus. The location of the displaced otoliths determines the variant of BPPV: BPPV of the posterior semicircular canal is the most common (around 65% of BPPVs), followed by BPPV of the horizontal canal, while BPPV of the anterior canal is rare, as it resolves spontaneously and rapidly. Although a benign condition, BPPV leads 9 times out of 10 to a medical consultation, interruption of daily activities, or sick leave. Untreated, it will usually recur, and can impact on patients' quality of life. conditions: Benign Paroxysmal Positional Vertigo studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 185 type: ESTIMATED measure: accurate BPPV diagnostics measure: therapeutic maneuvers performed measure: Satisfaction of clinicians who received the educational interventio sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Groupe Hospitalier Paris Saint-Joseph status: RECRUITING city: Paris zip: 75014 country: France name: Camille GERLIER, MD role: CONTACT phone: +331441228023 email: cgerlier@ghpsj.fr lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06314568 id: 6350 briefTitle: Radiochemotherapy and Interventional Radiotherapy in Vaginal Cancer acronym: TRIDENT overallStatus: RECRUITING date: 2024-03-15 date: 2026-03-31 date: 2028-12-31 date: 2024-03-18 date: 2024-04-04 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: Prospective observational multicenter study, aimed at evaluating the effectiveness on local control and cancer-specific survival of radiochemotherapy followed by interventional radiotherapy in patients affected by vaginal cancer conditions: Vaginal Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 278 type: ESTIMATED name: Radiochemotherapy plus interventional radiotherapy measure: Local Control measure: Cancer specific overall survival measure: Toxicities measure: Overall survivall measure: Disease free survivall measure: Metastasis free survival measure: Changes in quality of life over time sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fondazione Policlinico Universitario A. Gemelli IRCCS status: RECRUITING city: Roma zip: 00168 country: Italy name: VALENTINA LANCELLOTTA role: CONTACT phone: +390630155701 email: valentina.lancellotta@policlinicogemelli.it name: VALENTINA LANCELLOTTA role: PRINCIPAL_INVESTIGATOR lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06314555 id: CEROG2023 briefTitle: Impact of the sFlt-1/PlGF Ratio on Medical Decision-making and on Maternal and Neonatal Outcomes in Women Suspected of Preeclampsia overallStatus: COMPLETED date: 2019-10-01 date: 2021-01-27 date: 2021-01-27 date: 2024-03-18 date: 2024-03-18 name: Centre Hospitalier Universitaire de Saint Etienne class: OTHER briefSummary: Previous studies demonstrated that Placental Growth Factor (PIGF) and Vascular Endothelial Growth Factor (VEGF) produced by trophoblast cells decreases during Preeclampsia, whereas soluble fms-like tyrosine kinase-1 (sFlt-1), an antiangiogenic factor, increases. The ratio sFlt-1/PlGF has a higher positive predictive value than the isolated measurement. A ratio under 38 exclude risk of imminent preeclampsia and allows to outpatient follow-up with a negative predictive value of 99.3%. A ratio equal or higher than 38 permits to direct high-risk patients towards hospitalization with a positive predictive value of 36.7% of preeclampsia at 4 weeks. These findings suggest that the ratio can be used to select more appropriately women needing hospitalization for suspected preeclampsia. conditions: Preeclampsia Possible studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 314 type: ACTUAL name: Blood sample name: Vascular-renal sample measure: Doctor's medical care decisions on Hospitalization measure: Intensive monitoring measure: Corticosteroid administration for lung maturation measure: Birth induction sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chu Saint Etienne city: St Etienne zip: 42100 country: France lat: 45.43389 lon: 4.39 hasResults: False
nctId: NCT06314542 id: REC-001 briefTitle: Quantitative Evaluation of the Impact of Relaxing Eligibility Criteria for Lung Cancer Based on Real-world Data overallStatus: RECRUITING date: 2013-01-01 date: 2025-12-31 date: 2026-06-30 date: 2024-03-18 date: 2024-03-18 name: Cancer Institute and Hospital, Chinese Academy of Medical Sciences class: OTHER name: AstraZeneca briefSummary: Eligibility criteria for cancer drug trials are generally too stringent, leading to key issues such as low enrolment rates and lack of population diversity. In order to evaluate the REC of NSCLC drug trials, this study will use deep learning methods to construct a structured real-world database of NSCLC across dimensions, and quantitatively assess the independent contribution of changes in each eligibility criterion to patient numbers, clinical efficacy and safety. conditions: Lung Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 50000 type: ESTIMATED name: relaxing eligibility criteria measure: Scale of eligibility criteria sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Cancer Hospital, Chinese Academy of Medical Sciences status: RECRUITING city: Beijing country: China name: Ning Li role: CONTACT lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06314529 id: 2022-LTF-BHC001 briefTitle: Long-term Follow-up Study of BHC001 for TDT overallStatus: RECRUITING date: 2022-12-14 date: 2036-12-10 date: 2037-05-10 date: 2024-03-18 date: 2024-03-18 name: Bioray Laboratories class: INDUSTRY name: The 923rd Hospital of Joint Logistics Support Force of People's Liberation Army name: Xiangya Hospital of Central South University briefSummary: Observe long-term safety risk and long-term efficacy after intravenous infusion of BHC001 in TDT subjects. conditions: Thalassemia, Beta studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 6 type: ESTIMATED name: Assessments measure: Incidence of hematologic malignancies measure: Frequency, grade, and relationship of SAEs sex: ALL minimumAge: 5 Years maximumAge: 35 Years stdAges: CHILD stdAges: ADULT facility: The 923rd Hospital of Joint Logistics Support Force of People's Liberation Army status: RECRUITING city: Nanning state: Guangxi zip: 530021 country: China name: Xinhua Zhang, PhD role: CONTACT lat: 22.81667 lon: 108.31667 facility: Xiangya Hospital of Central South University status: RECRUITING city: Changsha state: Hunan zip: 510510 country: China name: Bin Fu, PhD role: CONTACT lat: 28.19874 lon: 112.97087 hasResults: False
nctId: NCT06314516 id: CRP17122 briefTitle: Influence of Nutrition and Sarcopenia on Esophageal Cancer Outcomes acronym: INSPECT overallStatus: COMPLETED date: 2017-12-27 date: 2024-02-28 date: 2024-02-28 date: 2024-03-18 date: 2024-03-18 name: Benaroya Research Institute class: OTHER name: Imperial College London briefSummary: Prospective multicenter longitudinal (observational) study recruiting from tertiary centers for the surgical management of esophageal cancer; Virginia Mason Medical Center (Seattle, USA) and St Mary's Hospital (Imperial College, London, UK). This is intended to be a pilot study. conditions: Esophageal Cancer conditions: Sarcopenia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 1717 type: ACTUAL measure: Longitudinal variation in body composition measure: Patient and disease-specific factors sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Virginia Mason Medical Center city: Seattle state: Washington zip: 98101 country: United States lat: 47.60621 lon: -122.33207 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2019-12-10 uploadDate: 2024-03-11T13:52 filename: Prot_000.pdf size: 1135477 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2019-01-15 uploadDate: 2024-03-11T13:53 filename: ICF_001.pdf size: 135983 hasResults: False
nctId: NCT06314503 id: 23-075_CORDIAL_FIH id: NL83843.000.23 type: OTHER domain: CCMO (Centrale Commissie Mensgebonden Onderzoek) briefTitle: First-in-human Study to Examine Safety of a New Peritoneal Dialysis Device (WEAKID) in End-stage Kidney Disease Patients acronym: CORDIAL overallStatus: RECRUITING date: 2024-01-22 date: 2024-12-31 date: 2024-12-31 date: 2024-03-18 date: 2024-03-18 name: UMC Utrecht class: OTHER name: European Commission, Horizon 2020 name: Dutch Kidney Foundation name: Health Holland name: Nanodialysis Ltd name: Università degli studi di Modena e Reggio Emilia (UNIMORE) name: Servicio Madrileno De Salud (SERMAS) name: PPI Healthcare Consulting Ltd briefSummary: The goal of this first-in-human clinical trial is to examine the safety and efficacy of treatment with a new peritoneal dialysis (PD) device called WEAKID (WEarable Artificial KIDney for peritoneal dialysis). This device, unlike conventional PD, allows for continuous flow of dialysate inside the abdominal cavity combined with continuous regeneration of spent dialysate thanks to sorbents that remove toxins from the fluid.
nctId: NCT06314490 id: ASOSCN2A briefTitle: Personalized Antisense Oligonucleotide Therapy for Rare Pediatric Genetic Disease: SCN2A overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-16 date: 2026-02-16 date: 2026-02-16 date: 2024-03-18 date: 2024-03-18 name: University of California, San Diego class: OTHER name: California Institute for Regenerative Medicine (CIRM) name: n-Lorem Foundation briefSummary: This research project entails delivery of a personalized antisense oligonucleotide (ASO) drug designed for a single pediatric participant with SCN2A associated developmental epileptic encephalopathy conditions: Genetic Disease studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 1 type: ACTUAL name: nL-SCN2A-002 measure: Seizure frequency measure: Motor function as measured by Dyskinetic Cerebral Palsy Functional Impact Scale measure: Motor function as measured by the motor skills domain of Vineland Adaptive Behavior Scales measure: Motor function as measured by the motor skills domain of Bayley Scales of Infant and Toddler Development measure: Gastrointestinal assessment as measured by the Bristol Stool Chart measure: Neurodevelopmental Function as measured by Aberrant Behavior Checklist measure: Neurodevelopmental Function as measured by Observer-Reported Communication Ability Measure measure: Neurodevelopmental Function as measured by the Vineland Adaptive Behavior Scales measure: Neurodevelopmental Function as measured by the Bayley Scales of Infant and Toddler Development sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Rady Children's Hospital city: San Diego state: California zip: 92123 country: United States lat: 32.71533 lon: -117.15726 hasResults: False
nctId: NCT06314477 id: HCB/2022/1204 briefTitle: Effect of CPAP Treatment in Patients With Severe Uncontrolled Asthma: The ASTHMA-SLEEP Trial overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-12 date: 2026-12 date: 2024-03-18 date: 2024-03-18 name: Hospital Clinic of Barcelona class: OTHER briefSummary: The aim of the study is to evaluate the impact of CPAP treatment on asthma control in patients with severe uncontrolled asthma and obstructive sleep apnea (OSA) conditions: Obstructive Sleep Apnea conditions: Asthma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 138 type: ESTIMATED name: CPAP treatment name: Hygienic and dietary advice measure: Asthma control questionnaire measure: Asthma control test measure: Lung function- forced expiratory volume in the first second (FEV1) in spirometry measure: Lung function-forced vital capacity (FVC) in spriometry measure: Prevalence of OSA in severe uncontrolled asthma measure: Inflammatory profile measure: Quality of life (Abbreviated Asthma Quality of life Questionnaire- mini-AQLQ questionnaire) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06314464 id: C2023.055 briefTitle: Portable Mixed Reality-based Platform for Assessment of Progress in Multisensory Rehabilitation Strategies Post-TBI acronym: Praxis overallStatus: ENROLLING_BY_INVITATION date: 2024-02-12 date: 2025-04-30 date: 2025-09-30 date: 2024-03-18 date: 2024-03-18 name: BlueHalo class: INDUSTRY name: Brooke Army Medical Center name: University of Pittsburgh briefSummary: The goal of this comparative pilot study is to provide evidence that Praxis, a portable testbed with low-cost wearable sensors and a mixed reality environment, can deliver effective multisensory rehabilitation exercises with military face-validity in a military service member (SM) population after mild Traumatic Brain Injury (mTBI).