hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06324383 id: 1782599 briefTitle: Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners overallStatus: NOT_YET_RECRUITING date: 2024-03-28 date: 2025-03-28 date: 2025-03-28 date: 2024-03-22 date: 2024-03-22 name: University of Michigan class: OTHER briefSummary: The goal of this study is to refine and test a strategy for engaging Veterans with symptoms of depression, anxiety, and/or PTSD as volunteers to help English language learners (ELLs) improve their speaking skills via structured conversations using videoconferencing. conditions: Depression, Anxiety, PTSD studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 80 type: ESTIMATED name: Intervention (videoconferencing) measure: France and Finney "Mattering" measure: (Patient Health Questionnaire) PHQ-8 measure: (Generalized Anxiety Disorder) GAD-7 measure: (Posttraumatic Stress Disorder Checklist) PCL-5 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Center for Clinical Management Research (CCMR), North Campus Research Complex city: Ann Arbor state: Michigan zip: 48109 country: United States lat: 42.27756 lon: -83.74088 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-12-28 uploadDate: 2024-03-12T11:49 filename: ICF_000.pdf size: 166776 hasResults: False
nctId: NCT06324370 id: FIERC-2022-023 briefTitle: Exploratory Pharmacokinetic Study of Virgin Coconut Oil (VCO) overallStatus: ACTIVE_NOT_RECRUITING date: 2023-04-13 date: 2024-06-30 date: 2024-06-30 date: 2024-03-22 date: 2024-03-22 name: Food and Nutrition Research Institute, Philippines class: OTHER_GOV name: Ateneo de Manila University name: De La Salle Medical and Health Sciences Institute briefSummary: This is a balanced, open-label, single- and multiple-dose pharmacokinetic (PK) study of virgin coconut oil (VCO) among healthy Filipino male adults 18-45 years of age in Dasmariñas, Cavite. This study aims to determine the rate and extent of absorption of virgin coconut oil (VCO) administered in healthy male human study participants under fed conditions in single and multiple doses and to monitor the safety and tolerability of virgin coconut oil (VCO) following the standard protocol developed by the De La Salle Medical and Health Sciences Institute (DLSMHSI). conditions: Pharmacological Action studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SEQUENTIAL interventionModelDescription: This will be a two-sequence (single- and multiple-dose) pharmacokinetic study in healthy Filipino male human participants under fed conditions. primaryPurpose: BASIC_SCIENCE masking: NONE maskingDescription: This will be an open-label pharmacokinetic study in healthy Filipino male human participants under fed conditions. count: 16 type: ACTUAL name: Virgin Coconut Oil measure: Pharmacokinetics (AUC0-t) measure: Pharmacokinetics (Cmax) measure: Pharmacokinetics (AUC0-inf) measure: Pharmacokinetics (tmax) measure: Pharmacokinetics (Kel) measure: Pharmacokinetics (t1/2) measure: Vital Signs (Systolic and Diastolic Blood Pressure) measure: Vital Signs (Pulse rate) measure: Vital Signs (Body temperature) measure: Vital Signs (Respiratory rate) measure: Safety and Tolerability (Adverse events) measure: Post Study Evaluation (Fasting Blood Sugar Test) measure: Post Study Evaluation (Blood Urea Nitrogen Test) measure: Post Study Evaluation (Creatinine) measure: Post Study Evaluation (Uric Acid) measure: Post Study Evaluation (Serum Glutamic Pyruvic Transaminase Test) measure: Post Study Evaluation (Serum Glutamic-oxaloacetic Transaminase Test) measure: Post Study Evaluation (Alkaline Phosphatase Test) measure: Post Study Evaluation (TPAG- Total Protein, Albumin, Globulin Ratio Test) measure: Post Study Evaluation (Indirect, Direct and Total Bilirubin) measure: Post Study Evaluation (Lipid Profile - High-density lipoprotein, Low-density lipoprotein, Cholesterol and Triglycerides) measure: Post Study Evaluation (Lipase Test) measure: Post Study Evaluation (Amylase Test) measure: Post Study Evaluation (Complete Blood Count with Platelet Count Test) measure: Post Study Evaluation (Complete Urinalysis) measure: Post Study Evaluation (Fecalysis) sex: MALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Department of Science and Technology-Food and Nutrition Research Institute (DOST-FNRI) city: Taguig state: Metro Manila zip: 1630 country: Philippines lat: 14.52429 lon: 121.07921 hasResults: False
nctId: NCT06324357 id: 1479-0012 briefTitle: Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib in Combination With Trastuzumab Deruxtecan or With Trastuzumab Emtansine and to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2027-02-22 date: 2028-08-21 date: 2024-03-21 date: 2024-04-24 name: Boehringer Ingelheim class: INDUSTRY briefSummary: This study is open to adults aged 18 years and older with different types of HER2+ cancer that has spread and cannot be removed by surgery. People can take part in this study if their tumours show HER2 aberrations and previous treatment was not successful. The purpose of this study is to find a suitable dose of zongertinib that people with different types of HER2+ cancer that has spread can tolerate best when taken together with trastuzumab deruxtecan (T-DXd) or with trastuzumab emtansine (T-DM1). Another purpose is to check whether zongertinib in combination with T-DXd or with T-DM1 can make tumours shrink. Zongertinib inhibits HER2. HER2 causes cancer cells to grow.
During the study, the participants visit the study site regularly. In this study, researchers want to find the highest dose of zongertinib that participants can tolerate when taken together with T-DXd or with T-DM1. To find this out, researchers look at certain severe health problems that a number of participants have. The doctors regularly check the size of the tumour with imaging methods (CT/MRI) during the study. The doctors also regularly check participants' health and take note of any unwanted effects. conditions: Metastatic Breast Cancer conditions: Metastatic Gastric Adenocarcinoma conditions: Gastroesophageal Junction Adenocarcinoma conditions: Esophageal Adenocarcinoma studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 240 type: ESTIMATED name: Zongertinib name: Trastuzumab deruxtecan name: Trastuzumab emtansine measure: Dose escalation (Phase Ib): Occurrence of dose-limiting toxicities (DLTs) in the maximum tolerated dose (MTD) evaluation period measure: Dose optimization (Phase II): Objective response (OR) measure: Dose escalation (Phase Ib): Objective response (OR) measure: Dose escalation (Phase Ib): Occurrence of dose-limiting toxicities (DLTs) during the entire treatment period measure: Dose escalation (Phase Ib): Maximum measured concentration of the analyte in plasma (Cmax) measure: Dose escalation (Phase Ib): Area under the concentration-time curve of the analyte in plasma from 0 to t2 (AUC0-t2) measure: Dose optimization (Phase II): Progression-free survival (PFS) measure: Dose optimization (Phase II): Disease control (DC) measure: Dose optimization (Phase II): Occurrence of treatment-emergent AEs leading to zongertinib (BI 1810631) dose reduction during the on-treatment period measure: Dose optimization (Phase II): Maximum measured concentration of the analyte in plasma (Cmax) measure: Dose escalation (Phase II): Area under the concentration-time curve of the analyte in plasma from 0 to t2 (AUC0-t2) measure: Dose optimization (Phase II): Patient-reported outcome (PRO) - PRO-CTCAE measure: Dose optimization (Phase II): Patient-reported outcome (PRO) - EORTC IL46 measure: Dose optimization (Phase II): Patient-reported outcome (PRO) - EORTC IL19 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06324344 id: H-50753-B briefTitle: Transcutaneous Electrical Nerve Stimulation (TENS) for Chemotherapy Induced Peripheral Neuropathy (CIPN) overallStatus: RECRUITING date: 2023-10-02 date: 2025-10-02 date: 2025-10-02 date: 2024-03-21 date: 2024-03-25 name: Baylor College of Medicine class: OTHER name: NeuroMetrix, Inc. briefSummary: The purpose of this pilot study is to examine the acceptability and proof of concept effectiveness of a wireless Transcutaneous Electrical Nerve Stimulation (TENS) technology to address Chemotherapy Induced Peripheral Neuropathy (CIPN). Participants, who satisfy the inclusion and exclusion criteria and sign the informed consent form will be randomly assigned with ratio of 1:1 into two groups. The patients and clinicians will be blinded for group allocation. One group will utilize TENS high-dose devices (Intervention group, IG); the other group will utilize low-dose TENS devices (Placebo group, PG). The baseline measurements will be performed, and the patients will take the programmed device home for a duration of 8 weeks. Then, the patients will come back after four weeks (4W) and after 8 weeks (8W) for outcome assessment. The primary outcome will be pain. Secondary outcomes include: nerve conduction and velocity, vibration perception threshold, quality of life. Exploratory outcomes include gait assessment (gait speed, stride length, double stance, and gait steadiness), and balance. conditions: Chemotherapy-induced Peripheral Neuropathy conditions: Pain conditions: Neuropathy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants who satisfy the inclusion and exclusion criteria and sign the informed consent form will be randomly assigned into two groups in a 1:1 ratio. One group will utilize high-dose TENS therapy (Intervention group, AG); the other group will utilize low-dose TENS devices (Placebo group, PG).
Throughout this 8-week period the participants may receive follow-up phone calls assessing their compliance. All subjects will keep their active device after completion of the 8-week study. primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: Double whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 30 type: ESTIMATED name: High-Dose TENS name: Low-Dose TENS measure: Change in pain level at 8 weeks from baseline measure: Change in vibration perception threshold at 8 weeks from baseline measure: Change in sural nerve conduction velocity and amplitude at 8 weeks from baseline measure: Changes in Quality of Life at 8 weeks from baseline measure: Changes in stride time at 8 weeks from baseline measure: Changes in cadence at 8 weeks from baseline measure: Changes in double-support phase at 8 weeks from baseline measure: Changes in Range of Motion (RoM) at 8 weeks from baseline sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Baylor College of Medicine status: RECRUITING city: Houston state: Texas zip: 77030 country: United States name: Bijan Najafi, PhD role: CONTACT phone: 713-798-7536 email: bijan.najafi@bcm.edu name: Maria Noun, BS role: CONTACT phone: 713-798-7538 email: maria.noun@bcm.edu lat: 29.76328 lon: -95.36327 hasResults: False
nctId: NCT06324331 id: Decidual sparing & CS niche briefTitle: Effect of Decidual Sparing in cs Niche Formation overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-09-01 date: 2025-12-01 date: 2024-03-21 date: 2024-03-21 name: Assiut University class: OTHER briefSummary: Assessing the impact of endometrial sparing at double-layer uterine closure as a specific surgical technique in CS to reduce the rate of post-cessarian delivery niche develoment conditions: Cesarean Section Complications conditions: Cesarean Section Niche studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: SCREENING masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 184 type: ESTIMATED name: Decidual sparing name: Non decidual sparing measure: Impact of decidual sparing on niche formation measure: Impact of uterine closure technique on post CS niche criteria sex: FEMALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06324305 id: SRF drainage techniques in RRD briefTitle: Comparative Study Between Three Different Techniques in Drainage of SRF During PPV in RRD overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12 date: 2025-04 date: 2024-03-21 date: 2024-03-21 name: Ain Shams University class: OTHER briefSummary: The study will investigate and compare the three techniques in drainage of subretinal fluid in patients with macula off RRD: namely using the original break, performing a posterior drainage retinotomy and using PFC with drainage through the original break or peripheral retinotomy regarding the presence of persistent sub-retnal fluid and related intra or postoperative complications conditions: Rhegmatogenous Retinal Detachment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 66 type: ESTIMATED name: Pars plana vitrectomy (PPV) and drainage of subretinal fluid measure: The presence versus absence of sub-macular fluid using each of the three different techniques in pars plana vitrectomy (PPV) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06324292 id: FDASU-RecID112324 briefTitle: Effect Of Digital Smile Design on Quality Of Life In Complete Denture Wearers overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-09-01 date: 2024-09-15 date: 2024-03-21 date: 2024-03-26 name: Ain Shams University class: OTHER briefSummary: The aim of the current study protocol is to compare the effect of two complete dentures made for completely edentulous patients; one digitally constructed using digital smile design (DSD) and another one conventionally constructed on the patient's quality of life and patient's satisfaction.
It is a clinical trial in which two dentures will be made for each patient, one will be digitally constructed using digital smile design (DSD) and the other one using the conventional method with a washout period of 3 weeks. Each patient will receive a questionnaire "Oral Health Impact Profile -19" (OHIP -19) for the edentulous patients to evaluate his satisfaction with the denture. conditions: Complete Edentulism studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: The participants allocated into two groups; a conventional denture followed by a digital group (CG) and a digital denture followed by a conventional one group (DG). primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: complete denture, CG name: complete denture, DG measure: quality of life assessment sex: ALL minimumAge: 40 Years maximumAge: 55 Years stdAges: ADULT facility: Faculty of Dentistry Ain Shams University city: Cairo zip: 11361 country: Egypt lat: 30.06263 lon: 31.24967 facility: Faculty of Dentistry, Ain Shams University city: Cairo zip: 11361 country: Egypt name: ahmed MA mohamed, Bsc, Msc,MD role: CONTACT phone: 01111191337 phoneExt: 020 email: ahmedmostafa@dent.asu.edu.eg lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06324279 id: 000017585 briefTitle: Cervical Sliding Sign to Predict Outcome of Induction of Labor overallStatus: ACTIVE_NOT_RECRUITING date: 2023-09-01 date: 2024-04-01 date: 2024-04-01 date: 2024-03-21 date: 2024-03-21 name: Ain Shams Maternity Hospital class: OTHER briefSummary: Assess the role of transvaginal ultrasound specifically a sign called cervical sliding sign, in the prediction of success of induction of labor.
The prediction of outcome of induction of labor has always been an important topic to all obstetricians. Bishop score is traditionally considered reliable way to predict the outcome of induction of labor by assessing the cervical dilatation, effacement, position, and consistence and assessing the level of the fetal head in the birth canal. Since The bishop score remains a highly subjective method for prediction of outcome of induction of labor, the use of sonographic measurements such as cervical sliding sign can be a better predictor of successful induction of labor.The presence of CSS was defined as the sliding of the anterior cervical lip on the posterior one under gentle pressure of the transvaginal probe.
Patients undergoing induction of labor with misoprostol will be checked for the cervical sliding sign. The mode of delivery, induction to active labor time and active labor to delivery time will be recorded and analysed to assess whether the sliding sign is an independent predictor of success of induction. conditions: Induction of Labor conditions: Transvaginal Ultrasound: Cervical Sliding Sign studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 130 type: ACTUAL name: Transvaginal ultrasound name: Misoprostol 200mcg Tab measure: Mode of delivery measure: Induction to active labor time measure: Active labor to delivery time sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Maternity hospital, ainshams university hospitals city: Cairo zip: 11799 country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06324266 id: 2023NZKY-044-02 briefTitle: Study on the Efficacy and Safety of Low-dose CTX as Maintenance Therapy for MM Unsuitable for Transplantation overallStatus: RECRUITING date: 2023-04-16 date: 2025-12-31 date: 2025-12-31 date: 2024-03-21 date: 2024-03-21 name: Jinling Hospital, China class: OTHER briefSummary: The investigators will conduct randomized and controlled clinical studies in order to preliminarily explore the efficacy and safety of low-dose cyclophosphamide and lenalidomide in maintenance therapy for MM that is not suitable for transplantation in the standard-risk group. conditions: Newly Diagnosed Multiple Myeloma studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 80 type: ESTIMATED name: Cyclophosphamide name: Lenalidomide measure: PFS1 measure: Incidence of Efficacy as assessed by IMWG measure: Incidence of Safety as assessed by CTCAE 4.0 sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Jinling Hospital status: RECRUITING city: Nanjing state: Jiangsu country: China name: Zhao Qian role: CONTACT phone: 18251835035 email: 540598707@qq.com lat: 32.06167 lon: 118.77778 hasResults: False
nctId: NCT06324253 id: 1/24 UROL2 briefTitle: Thoracic Epidural Analgesia With Bilateral Erector Spinae Plane Block in Radical Cystectomy Surgery acronym: TEAvsESB overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-01 date: 2024-05-10 date: 2024-06-10 date: 2024-03-21 date: 2024-03-21 name: Menoufia University class: OTHER name: Amal Ismael Abdelrahman Hassan name: Ibrahim Mowafy Gomaa Atawia briefSummary: The aim of this study is to compare between Thoracic Epidural Analgesia (TEA) with ultrasound-guided bilateral erector spinae plane (ESP) block in radical cystectomy surgery for analgesic efficacy and hemodynamic effects conditions: Post Operative Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Group A: will receive bilateral Erector Spinae Block after induction of anesthesia.
Group B: will receive Thoracic Epidural Block before induction of anesthesia. primaryPurpose: OTHER masking: NONE count: 20 type: ACTUAL name: bilateral Erector spine block,A dose of 30 ml 0.125% Bupivacaine will be injected. name: Thoracic epidural analgesia measure: Time for first rescue analgesia measure: Visual analogue scale score at 1st,2nd,4th,6th,8th,12th and 24 h (where 0 is interpreted as no pain, 1-4 mild pain, 5-6 moderate pain, 7-10 severe pain) measure: the number of rescue analgesics within 24hrs after surgery measure: The heart rate, mean arterial blood pressure measure: Complications like bradycardia or hypotension, intraoperative and postoperative dysrhythmia, nausea and vomiting sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Menoufia university city: Cairo state: Shibin Elkom country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06324227 id: 311203003 briefTitle: Effects of Multimodal Music Intervention on Mild Cognitive Impairment Elderly overallStatus: RECRUITING date: 2023-09-17 date: 2024-03-26 date: 2024-05-26 date: 2024-03-21 date: 2024-03-21 name: National Yang Ming University class: OTHER briefSummary: The goal of this clinical trial is to learn about whether music therapy can ameliorate cognitive function, physical fitness and psychology in mild cognitive impairment and mild dementia population. The main questions it aims to answer are:
2. To discuss the effect of twelve-week multimodal music therapy in ameliorating community-based elders with MCI and mild dementia. Main outcome variables: cognitive function (Montreal Cognitive Assessment Scale, trail making test, Saint Louis University Mental Status Examination). Secondary outcome variables: physical fitness (muscle strength, muscular endurance, flexibility, balance ability), depression. conditions: Mild Cognitive Impairment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: PREVENTION masking: NONE count: 50 type: ESTIMATED name: multimodal music therapy name: no intervention measure: Montreal Cognitive Assessment measure: Saint Louis University Mental Status measure: Trail Making Test measure: 30s chair stand measure: back scratch test measure: sit and reach test measure: 8-foot up-and-go test measure: handgrip measure: Geriatric Depression Scale 15 items sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: NationalYangMingU status: RECRUITING city: Taipei country: Taiwan name: Wei Zu Lo role: CONTACT phone: 02-2823-9753 phoneExt: 66378 email: weitzu@nycu.edu.tw lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06324214 id: 2023-9352 briefTitle: Oral Supplementation During PR Participation in COPD overallStatus: RECRUITING date: 2024-03-11 date: 2025-03-04 date: 2025-05-31 date: 2024-03-21 date: 2024-04-02 name: McGill University Health Centre/Research Institute of the McGill University Health Centre class: OTHER name: Amazentis SA briefSummary: Chronic obstructive pulmonary disease (COPD) is a very common and chronic lung condition and is a leading cause of morbidity and death. These patients have persistent breathlessness and exercise intolerance, affecting their ability to carry out routine daily tasks. Standard COPD treatments include medicines/puffers as well as participation in a Pulmonary Rehabilitation (PR) program. PR programs are delivered by a diverse team of healthcare experts in exercise and nutrition. It is possible that an emerging nutritional oral supplement could target the muscular dysfunction seen in patients with COPD in part by promoting better working mitochondria, the energy 'engine' of muscle. A series of recently published studies in sedentary adults and in older adults have demonstrated the safety, tolerability, and potential clinical effectiveness of this supplement.
In this regard, the investigators plan to lead a large randomized controlled trial (RCT) to test whether oral supplementation in patients with COPD who are also participating in a standard PR program will improve overall exercise performance. The investigators will also test muscle strength, cognition, body composition, and other clinically important outcomes such as quality of life. Lastly, the investigators will use muscle tissue from a subgroup of volunteers to investigate the effect on muscle/mitochondrial structure/function.