hackint0sh/New-Dataset huggingface dataset:
This project proposes the concept of achieving precise diagnosis of RA based on synovial pathology classification, and explores the efficacy of early methotrexate combined with tofacitinib intensified treatment for patients with synovial medullary stromal RA who have poor conventional treatment efficacy, providing high-level clinical evidence for achieving precise initial treatment of RA treatment guidelines. conditions: Rheumatoid Arthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 130 type: ESTIMATED name: Methotrexate Combined With Tofacitinib name: Methotrexate measure: The proportion of subjects who achieved ACR20 measure: Changes in disease activity scores (DAS28-CRP) relative to baseline measure: Changes in disease activity scores (DAS28-ESR) relative to baseline measure: Changes in disease activity scores (SDAI) relative to baseline measure: Changes in disease activity scores (CDAI) relative to baseline measure: Proportion of subjects with low disease activity and remission (SDAI standard) at weeks 4, 8, 12, 24, 36, and 48 after treatment measure: The proportion of subjects who met ACR50 criteria at weeks 4, 8, 12, 24, 36, and 48 after treatment measure: The proportion of subjects who met ACR70 criteria at weeks 4, 8, 12, 24, 36, and 48 after treatment measure: Changes in the Disability Index (HAQ-DI) of the Health Assessment Questionnaire relative to baseline measure: Changes in EQ-5D-5L relative to baseline measure: The proportion of subjects with joint destruction progression at 48 weeks after treatment measure: The proportion of adverse events (AE) in subjects at 4, 8, 12, 24, 36, and 48 weeks after treatment measure: The proportion of severe adverse events (SAE) in subjects at 4, 8, 12, 24, 36, and 48 weeks after treatment measure: Changes in serum MMP-3 levels relative to baseline sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06301360 id: KOSMOS2 2023-04956-01 briefTitle: Internet Based Emotional Awareness and Expression Therapy for Functional Somatic Disorder With and Without Therapist Support overallStatus: RECRUITING date: 2023-12-01 date: 2025-06-01 date: 2025-12-31 date: 2024-03-08 date: 2024-03-12 name: Daniel Maroti class: OTHER name: Wayne State University briefSummary: Functional somatic syndromes (e.g. irritable bowel syndrome, fibromyalgia) and medically unexplained symptoms (e.g. chronic primary pain) are very common in primary care. These patients make 14 times more doctor visits than the general population, but describe themselves as less satisfied with the care they receive. Although Region Stockholm in Sweden recently developed care flows based on 'step up' care for the most common patient groups in primary care, patients with functional or medically unexplained symptoms are not mentioned.
Short-term psychodynamic therapies such as Emotional Awareness and Expression Therapy (EAET) and Intensive Short Term Psychodynamic Therapy (ISTDP) have recently been evaluated in three systematic reviews and show good results for patients with medically unexplained symptoms. Short-term psychodynamic therapy considers that good treatment outcomes for patients with functional somatic syndromes can be achieved by increasing awareness of emotions and teaching patients to better experience, express and regulate emotions. In several randomized studies, short-term psychodynamic therapy has shown good effects even compared to other treatments, including cognitive behavioral therapy (CBT).
Is internet-based Emotional Awareness and Expression Therapy (I-EAET) with therapist more effective than without therapist support for patients with FSD? conditions: Functional Somatic Disorder conditions: Somatic Symptom Disorder conditions: Functional Somatic Syndromes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: RCT with two treatment arms primaryPurpose: TREATMENT masking: NONE count: 150 type: ESTIMATED name: Internet based Emotional Awareness and Expression Therapy (I-EAET) measure: Patient Health Questionnaire -15 (PHQ-15) measure: Numeric Rating Scales according to EURONET-SOMA measure: Generalized Anxiety Disorder-7 (GAD-7) measure: Patient Health Questionnaire-9 (PHQ-9) measure: Post traumatic stress disorder checklist-5 (PCL-5) measure: Difficulties in Emotion Regulation Scale-16 (DERS-16) measure: Sheehan Disability Scale (SDS) measure: The revised illness perception questionnaire (IPQ-R) measure: Mediational measure: DERS-16 measure: Mediational measure: PHQ-15 measure: Mediational measure: PHQ-4 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Stockholm University status: RECRUITING city: Stockholm zip: 10691 country: Sweden name: Daniel Maroti, Med Dr role: CONTACT phone: +46738028474 email: daniel.maroti@su.se lat: 59.33258 lon: 18.0649 facility: Stockholm University status: RECRUITING city: Stockholm zip: 11419 country: Sweden name: Daniel Maroti role: CONTACT phone: 0738028474 email: daniel.maroti@su.se lat: 59.33258 lon: 18.0649 hasResults: False
nctId: NCT06301347 id: LTP+P briefTitle: Learning Through Play Plus for Psychosis overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-30 date: 2025-12-30 date: 2024-03-08 date: 2024-03-08 name: Pakistan Institute of Living and Learning class: OTHER briefSummary: Evidence reports that parents with schizophrenia are particularly vulnerable to parenting difficulties and also experience problems in sensitively interacting with their children. This may cause insecure attachment in infants of mothers with psychosis. Children of parents with schizophrenia have poor developmental and clinical outcomes. However, there is no published trial, to the best of our knowledge, for children of parents with schizophrenia. Learning through Play (LTP) is a potentially low cost intervention to improve maternal mental health and child outcomes by promoting health child development. The proposed study will integrate LTP with existing culturally appropriate Cognitive Behaviour Theray (CBT) for psychosis (CaCBT-p) and test its feasibility and acceptability for parents with schizophrenia. conditions: Psychosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants will be randomized into one of the two treatment conditions (LTP Plus or TAU) through computer generated algorithm. primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: Learning through Play Plus measure: Recruitment Rate measure: Attrition Rate measure: Intervention attendance log measure: Positive and Negative Syndrome Scale measure: Psychotic Rating Scale measure: Parenting Stress Index measure: Maternal Attachment Inventory measure: Knowledge attitude and practices of Child Development measure: Calgary Depression Scale measure: Social and Occupational Functioning Scale measure: Euro-Qol 5 Dimensions measure: Client Service Receipt Inventory measure: Ages and Stages Questionnaire measure: Manchester Assessment of Caregiver-Infant Interaction measure: Bayley Scale of infant development measure: Child Height measure: Child Weight measure: Child head circumference sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06301334 id: Soh-Med-24-01-11MS briefTitle: Block and Erector Comparative Study Between Costotransverse Spinae Plane Block in Patients Undergoing Thoracotomy overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-08-01 date: 2024-08-01 date: 2024-03-08 date: 2024-03-08 name: Sohag University class: OTHER briefSummary: A thoracotomy requires a very painful incision, involving multiple muscle layers, rib resection and continuous motion as the patient breathes. Treatment of acute post thoracotomy pain is particularly important not only to keep the patient comfortable but also to minimize pulmonary complications
Though epidural analgesia was once considered as the gold standard for post-thoracotomy pain management, it is not recommended for pain control after thoracotomy surgery because it is associated with high potential risks of dural puncture, nerve lesions, epidural hematoma and hypotension(4). Thoracic paravertebral block (TPVB) and intercostal nerve block are well described and recognized techniques for postoperative analgesia following thoracic surgeries, such as thoracotomy and mastectomy conditions: Pain Mangement of Thoracotomy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Bupivacaine 0.25% Injectable Solution measure: study aims to compare the analgesic efficacy of CTB and ESPB for post-operative analgesia in patients undergoing thoracotomy. measure: The secondary outcome is the total postoperative morphine consumption, time of first analgesic, sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06301321 id: 461_2566 briefTitle: The Evaluation and Comparison of BCR-ABL p210 mRNA Transcripts (%IS Unit) Results Between Dr. PCR™ BCR-ABL1 Major IS Detection Kit (Optolane) and QXDx™ BCR-ABL %IS Kit (Bio-Rad) in Chronic Myeloid Leukemia Patients acronym: BCR-ABL1 overallStatus: RECRUITING date: 2024-03-20 date: 2024-03-30 date: 2024-07-30 date: 2024-03-08 date: 2024-03-08 name: Siriraj Hospital class: OTHER briefSummary: Today, there are many commercial kits for detecting BCR-ABL fusion transcripts. The QXDx™ BCR-ABL %IS kit (Bio-Rad, Hercules, CA, USA) is the first ddPCR-based in vitro diagnostics (IVD) product with the US Food and Drug Administration clearance and European Conformity (CE) mark which launched in 2017. Dr. PCR™ BCR-ABL1 Major IS Detection Kit (Optolane, South Korea) is one of CE-IVD commercial kits based on digital RT-PCR. Both commercial kits are digital PCR-based, also evaluated their correlation, pros and cons in order for users to select a reagents kit that are appropriate for themselves. conditions: Chronic Myelogenous Leukemia studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 80 type: ESTIMATED measure: Sensitivity measure: Specificity sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Siriraj hospital status: RECRUITING city: Bangkok zip: 10700 country: Thailand name: weerapat Owattanapanich, MD role: CONTACT phone: 0891081963 email: weerapato36733@gmail.com name: Wananchi Saisaard, MT role: CONTACT phone: 0817141717 email: wern.si12@gmail.com name: weerapat Owattanapanich, MD role: PRINCIPAL_INVESTIGATOR lat: 13.75398 lon: 100.50144 hasResults: False
nctId: NCT06301308 id: 2022021 briefTitle: A Novel Application of 2% Lidocaine Injection for Male Rigid cycstoscopy-a Patient-blinded Randomised Trial overallStatus: WITHDRAWN date: 2023-10-01 date: 2024-02-29 date: 2024-02-29 date: 2024-03-08 date: 2024-04-24 name: Second Xiangya Hospital of Central South University class: OTHER briefSummary: The goal of this clinical trial is to learn about a novel application of lidocaine injection in male patients who needs rigid cycstoscopy test. The main question it aims to answer is:Does New Application of Lidocaine Liquid Provide Pain Relief for Patients During Cystoscopy? Before the cycstoscopy,Participants will be randomly divided into three different anesthesia mode groups,namely are Group A (intraurethral lidocaine gel alone), Group B (intraurethral lidocaine gel + lidocaine 2% injection), and Group C (intraurethral lidocaine gel + liquid paraffinl).Patients only need to prepare and cooperate according to routine surgical operations，which is group B or group C. conditions: Bladder Cancer studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: PARTICIPANT count: 0 type: ACTUAL name: Intraurethral lidocaine gel alone name: Intraurethral lidocaine gel + lidocaine 2% injection name: intraurethral lidocaine gel + liquid paraffinl measure: Access the pain score using the Visual Analogue Scale (VAS) measure: Postoperative complications sex: MALE maximumAge: 50 Years stdAges: CHILD stdAges: ADULT facility: The second xiangya hospital city: Changsha state: Hunan zip: 410000 country: China lat: 28.19874 lon: 112.97087 typeAbbrev: Prot_SAP_ICF hasProtocol: True hasSap: True hasIcf: True label: Study Protocol, Statistical Analysis Plan, and Informed Consent Form date: 2024-01-01 uploadDate: 2024-03-03T08:40 filename: Prot_SAP_ICF_000.pdf size: 387410 hasResults: False
nctId: NCT06301295 id: 2402-017-136 briefTitle: Feasibility of Targeted Bronchial Washing Fluid for Molecular Testing With Next Generation Sequencing in Patients Suspicious of Early-stage Lung Cancer overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-12-31 date: 2026-12-31 date: 2024-03-08 date: 2024-03-08 name: Pusan National University Hospital class: OTHER briefSummary: This is a single center, clinical trial evaluating the relevance of intratumoral washing for detection of generic alteration with Next Generation Sequencing. conditions: Lung Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 50 type: ESTIMATED name: Ultarthin bronchoscopy with intratumoral washing measure: Genetic alteration with Next Generation Sequencing detection rate in intratumoral washing fluid measure: Concordance rate of genetic alteration with Next Generation Sequencing detection rate among intratumoral washing fluid, plasma, and tissue measure: Turn-around time measure: Genetic alteration with Next Generation Sequencing sensitivity & specificity in intratumoral washing fluid sex: ALL minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06301282 id: 2021-02341 briefTitle: Electroencephalographic Signatures of Neuropsychiatric Fluctuations in Parkinson's Disease acronym: Transition overallStatus: RECRUITING date: 2023-03-03 date: 2025-12 date: 2025-12 date: 2024-03-08 date: 2024-03-08 name: University Hospital, Geneva class: OTHER briefSummary: Dopaminergic replacement therapy while efficient at reducing symptoms of Parkinson's disease is however often associated with motor and non-motor fluctuations which have a severe impact on patient quality of life. To date, the interplay between cortical activity linked to motor and non-motor symptoms and Parkinson's disease fluctuations linked to dopaminergic medication remain poorly understood.
This research will allow to precisely disentangle the network dynamics subtending motor and non-motor symptoms of Parkinson's disease as well as precisely identify the electroencephalographic spectral modulations explaining the neuropsychiatric effects of levodopa. The identification of such biomarkers could pave the way toward innovative therapeutic approaches such as neurofeedback and transmagnetic stimulation. conditions: Parkinson Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 30 type: ESTIMATED name: assessment during the transition between OFF-levodopa (i.e. withdrawal of levodopa phase) and ON-levodopa (i.e. effect of Levodopa phase)states measure: Correlation of electroencephalographic resting-state oscillatory activity with neuropsychiatric clinical scores during the levodopa challenge measure: Correlation of electroencephalographic resting-state oscillatory activity with motor scores during the levodopa challenge sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital, Geneva status: RECRUITING city: Geneva zip: 1204 country: Switzerland name: Vanessa Fleury, MD role: CONTACT phone: +41223728337 email: Vanessa.FleuryNissen@hcuge.ch lat: 46.20222 lon: 6.14569 hasResults: False
nctId: NCT06301269 id: 202312124RINA briefTitle: A Study on Self-Compassion,Depression,and Quality of Life Among Primary Caregivers of People With Dementia overallStatus: RECRUITING date: 2024-03-10 date: 2024-05-30 date: 2024-07-30 date: 2024-03-08 date: 2024-03-08 name: National Taiwan University Hospital class: OTHER briefSummary: The goal of this observational study is to investigate the correlation between self-compassion, depression, and quality of life among primary caregivers of persons with dementia.
Participants will fill out the questionnaire to complete the study. conditions: Dementia studyType: OBSERVATIONAL observationalModel: FAMILY_BASED timePerspective: CROSS_SECTIONAL count: 160 type: ESTIMATED measure: Self-Compassion Scale measure: PHQ-9 Scale measure: Quality-of-Life Scale sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Taiwan University Hospital status: RECRUITING city: Taipei zip: 100 country: Taiwan name: wen lin YE role: CONTACT phone: +886-2312-3456 email: vovo951357@ntuh.gov.tw lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06301256 id: I8F-NS-I002 briefTitle: Evaluate the Efficacy of TIRZEPATIDE for the Treatment of Moderate to Severe HS Hidradenitis Suppurativa overallStatus: NOT_YET_RECRUITING date: 2024-03-11 date: 2025-03-11 date: 2025-03-11 date: 2024-03-08 date: 2024-03-08 name: Florida Academic Centers Research and Education, LLC class: INDUSTRY briefSummary: The purpose of this study is to determine the clinical efficacy and safety of tirzepatide in subjects with moderate to severe hidradenitis suppurativa. The study will be conducted over 24 weeks on active therapy followed by a eight-week observational follow-up visit. The total length of the study will be 32 weeks . conditions: Hidradenitis Suppurativa studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: TIRZEPATIDE measure: Hidradenitis Suppurativa Clinical Response (HiSCR) 50% sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06301243 id: FY24-62 briefTitle: Molecular Signature of Inactivity Induced Exercise Responsiveness overallStatus: RECRUITING date: 2024-01-01 date: 2025-12-31 date: 2025-12-31 date: 2024-03-08 date: 2024-03-08 name: Concordia University Wisconsin class: OTHER briefSummary: Fitness is one of the best predictors for heart and brain disease. To increase ones fitness, the American Heart Association (AHA) says to exercise at least 150 minutes per week or 75 minutes per week if really hard. These exercise guides are pretty effective, however not everyone will get the same results. What individuals do outside of the exercise bout can influence the effectiveness of exercise. One of these factors is our time sitting, which has caused the phrase "sitting is the new smoking". Other studies have said that the metabolic benefits of exercise are decreased when you exercise after a few days of low activity (less than 5,000 steps per day). This is important in that exercise may not be able to fully offset these times of inactivity. However, these studies were only looking at different fats in the blood. As exercise increases fat burn up to 10 times in the muscle, more research is needed to understand how inactivity affects the muscle during exercise and after exercise. This study will help answer two questions: 1) How does a day of sitting a lot affect the muscle's ability to respond to exercise? and 2) How does a day of sitting a lot affect carbohydrate and fat burn during and after a bout of exercise? The investigators will answer these questions by having people complete one day of inactivity (less than 5,000 steps) or normal activity (more than 8,500 steps). Subjects will then come in the next day to bike somewhat hard for 1 hour. The investigators will take blood samples before, during, and after exercise to measure energy sources. The investigators will also collect pieces of skeletal muscle before and after exercise to see how the muscle responded to exercise. This study is significant for the publication of exercise guidelines to minimize risk of heart and metabolic diseases. conditions: Metabolic Diseases conditions: Aerobic Exercise studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: NONE count: 10 type: ESTIMATED name: Inactivity measure: Circulating lipid and carbohydrate metabolism measure: Basal and post-exercise gene expression with inactivity sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Kevin J Gries status: RECRUITING city: Mequon state: Wisconsin zip: 53092 country: United States name: Kevin J Gries, PhD role: CONTACT phone: 262-243-4293 email: kevin.gries@cuw.edu lat: 43.21573 lon: -88.02962 hasResults: False
nctId: NCT06301230 id: PLET-2022 briefTitle: Home- vs. Hospital-based Surgical Training overallStatus: COMPLETED date: 2020-09-01 date: 2021-12-31 date: 2021-12-31 date: 2024-03-08 date: 2024-03-08 name: Clarunis - Universitäres Bauchzentrum Basel class: OTHER name: University of Basel briefSummary: The purpose of this study was to assess the effect of training with a personal, portable laparoscopic endo-trainer (PLET) on residents' laparoscopic skills. All participants were randomised to either a home- or hospital-based PLET training group and surgical skill performance was assessed using five laparoscopic exercises. Endpoints consisted ofsubjective and objective assessment ratings as well as exercise time and qualitative data up to 12 weeks. The primary outcome was the difference in exercise time and secondary outcomes included performance scores as well as qualitative data. conditions: Surgical Training studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 24 type: ACTUAL name: Portable Laparoscopic Trainer (PLET) measure: Exercise time measure: Assessment rating measure: Qualitative feedback sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clarunis Universitäres Bauchzentrum Basel city: Basel zip: 4002 country: Switzerland lat: 47.55839 lon: 7.57327 hasResults: False
nctId: NCT06301217 id: NO: PT. BU. EC. 7 briefTitle: Are Axioscapular Muscles Activity and Cervical Curvature Associated With Disability in Neck Pain overallStatus: ACTIVE_NOT_RECRUITING date: 2023-12-17 date: 2024-03-10 date: 2024-03-20 date: 2024-03-08 date: 2024-03-08 name: Delta University for Science and Technology class: OTHER briefSummary: Despite the important role of axioscapular muscles electromyography and cervical posture as outcomes for the management of chronic neck non specific pain , there is gab of evidence that highlight their association to the commonly used neck disability index. The quest to improve outcomes for individuals suffering from chronic nonspecific neck pain is underscored by the need to identify key prognostic variables that can guide clinical decision-making and intervention strategies. This study seeks to bridge the gap in research by examining the association between neck disability index score, cervical sagittal curvature, and axioscapular muscles electromyography in forms of both trapezius and levator scapula root mean squares to indicate muscular activities and median frequencies to indicate muscular fatigue. conditions: Neck Pain conditions: Electromyohgraph studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ACTUAL name: There is no intervention measure: Neck disability measure: Curvature angle of the cervical spine measure: root-mean-square value (RMS) of Surface electromyography for both upper trapezius and levator scapula sex: ALL minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Delta university for science and technology city: Gamasa state: Dakahleya zip: 7731168 country: Egypt lat: 31.44112 lon: 31.53675 hasResults: False