hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06315153 id: KS2023077-1 briefTitle: Comprehensive Assessment of Atherosclerotic Ischemic Stroke Risk and Development of a Prediction Model acronym: CAIS-pre overallStatus: ACTIVE_NOT_RECRUITING date: 2022-01-03 date: 2024-04-01 date: 2026-04-01 date: 2024-03-18 date: 2024-03-18 name: Xuanwu Hospital, Beijing class: OTHER name: The First Hospital of Jilin University briefSummary: This observational study was designed for the assessment of plaque vulnerability in patients with carotid atherosclerotic stenosis and the development of predictive models for the occurrence and recurrence of atherosclerotic ischemic stroke.
The objectives of the study were as follows: first, to integrate the degree of carotid stenosis and plaque characteristics assessed by vascular ultrasound for a comprehensive assessment of plaque vulnerability; second, to develop an assessment tool for the risk of future ischemic stroke in patients with asymptomatic carotid stenosis by combining vascular risk factors, serologic markers, carotid ultrasound characteristics, and contrast-enhanced ultrasonographic parameters; and third, to incorporate vascular ultrasound parameters into existing predictive models of ischemic stroke recurrence risk to develop a risk assessment tool for atherosclerotic ischemic stroke.
* How to improve the prediction accuracy of atherosclerotic ischemic stroke based on existing prediction models for secondary prevention of stroke. conditions: Carotid Stenosis conditions: Ischemic Stroke studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 500 type: ESTIMATED measure: The occurrence of ischemic stroke measure: The recurrence of ischemic stroke sex: ALL minimumAge: 40 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The first hospital of Jilin university city: Changchun state: Jilin zip: 130021 country: China lat: 43.88 lon: 125.32278 facility: Xuanwu Hospital, Capital Medical University city: Beijing zip: 100053 country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06315140 id: 22-00248 id: 1R01ES033545-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R01ES033545-01 id: 5R01ES033545-02 type: NIH link: https://reporter.nih.gov/quickSearch/5R01ES033545-02 briefTitle: Assessing and Addressing Community Exposures to Environmental Contaminants overallStatus: RECRUITING date: 2023-02-16 date: 2027-04 date: 2027-04 date: 2024-03-18 date: 2024-03-18 name: NYU Langone Health class: OTHER name: National Institute of Environmental Health Sciences (NIEHS) briefSummary: The purpose of this study is to build on our equitable, eight-year Tribal-academic partnership with the Ramapough Nation of northern NJ to advance tradition-centered farming practices and management strategies supporting sustainable food systems to relieve local food insecurity and nutritional deficiency, prevent disease and promote health. Furthermore, assessing the extent of environmental contamination, individual toxicant burdens and micronutrient levels and health disorders in Ramapough Tribal members of both sexes as outlined in the following:
* Test soil, plants and surface water where Turtle Clan residents live, recreate and attend church in Ringwood, NJ using a community-based, citizen scientist approach. conditions: Environmental Exposure studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: PROSPECTIVE count: 400 type: ESTIMATED measure: Proportion of individuals with heavy metal contaminants in home water samples measure: Proportion of individuals with heavy metal and metalloid contaminations in blood biospecimens measure: Proportion of individuals with heavy metal and metalloid contaminations in urine biospecimens measure: Proportion of individuals with insufficient blood serum micronutrient levels measure: Proportion of individuals with health disorders sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: NYU Langone Health status: RECRUITING city: New York state: New York zip: 10016 country: United States lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06315101 id: K-2023-092 briefTitle: Effectiveness and Safety of Lenvatinib Combined With Chinese Herbal Medicine for Patients With Unresectable Hepatocellular Carcinoma: A Real-world Study in China overallStatus: COMPLETED date: 2023-09-01 date: 2023-12-31 date: 2023-12-31 date: 2024-03-18 date: 2024-03-18 name: Guangzhou University of Chinese Medicine class: OTHER briefSummary: This study aims to assess the effectiveness and safety of lenvatinib plus Chinese Herbal Medicine (CHM) for patients with uHCC in China. conditions: Unresectable Hepatocellular Carcinoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 142 type: ACTUAL name: Chinese Herbal Medicine measure: Efficacy outcomes measure: Survival analysis measure: Survival analysis measure: Adverse Events assessment sex: ALL minimumAge: 18 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: the First Affiliated Hospital of Guangzhou University of Chinese Medicine city: Guangzhou state: Guangdong zip: 510407 country: China lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06315088 id: 69HCL24_0144 briefTitle: Food Biodiversity and Human Health acronym: BIOQUALIM overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2025-03-01 date: 2025-03-01 date: 2024-03-18 date: 2024-03-18 name: Hospices Civils de Lyon class: OTHER briefSummary: In Western countries, one of the major nutritional challenges requires reducing the proportion of animal proteins and increasing the proportion of vegetable proteins in the daily plate. Added to this nutritional challenge is an environmental challenge, with plant proteins being much less expensive to produce. However, plant proteins are mainly provided by cereals and legumes, a large diversity of which is necessary to cover the recommended daily intake of amino acids. However, given the collapse of cultivated biodiversity (loss of 75% in 100 years, FAO), the diversity of the supply is very reduced.
Furthermore, for several years, public health studies have indicated a chronic deficit in micronutrients (minerals/trace elements, vitamins, antioxidants) as well as fiber in the diet of the French population. This comes in particular from the impoverishment of the nutritional quality of the fruits/vegetables/cereals/legumes consumed. In general, diet plays a major role in the primary prevention of chronic diseases (cardiovascular, diabetes, cancer) including periodontal disease. Thus, a diet low in sugars, saturated fats and rich in fiber would reduce the appearance of periodontal disease by strengthening salivary capacity. However, certain pathogenic periodontal bacteria (such as Porphyromonas gingivalis) can migrate (blood, digestive or respiratory routes) to reach other organs and represent a risk factor for other chronic diseases. Thus, the prevention of periodontal diseases through diet control would also contribute to the prevention of other chronic diseases.
Furthermore, the potential impact of the oral microbiota on chronic diseases is now being studied: in healthy adults, a dysbiotic periodontal microbiota may be likely to lead to systemic para-inflammation. It has also been shown that a dietary change (Mediterranean diet) could lead to a reduction in pathogenic bacteria in the oral microbiota (including P. gingivalis). However, the link between the introduction of cereals into the diet and the evolution of cancer risk factor bacteria in the oral microbiota has never been demonstrated.
This pilot clinical study plans to focus on the oral microbiota, with the aim of objectivizing a possible link between a modification of the diet by the introduction of cereals (einkorn type) and the evolution of certain bacteria of this microbiota. , notably P. gingivalis (but also T. forsythia, S. anginosus, A. actinomycetemcomitans, T. denticola and F. nucleatum), considered as cancer risk factors and thus observe an improvement in health status oral and general. conditions: Oral Microbiota conditions: Periodontal Diseases studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 10 type: ESTIMATED name: Einkorn Diet name: Intermediate oral microbiota name: Periodontal health status name: General health status measure: Total periodontal bacteria count measure: Intermediate periodontal bacteria count measure: Periodontal health analysis:plaque index measure: Periodontal health analysis: gingival index measure: Periodontal health analysis : pocket depth and loss of clinical attachment measure: Periodontal health analysis : interdental inflammation measure: Periodontal health analysis : salivary pH measure: General health analysis : body mass index measure: General health analysis : measurement of abdominal circumference measure: General health analysis : blood pressure measure: General health analysis : MOS SF-36 quality of life questionnaire measure: General health analysis : eating habits sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Maison des professionnels city: Lyon zip: 69000 country: France name: Bourgeois Denis, MD,PhD role: CONTACT phone: 04 27 85 40 00 email: denis.bourgeois@chu-lyon.fr lat: 45.74848 lon: 4.84669 hasResults: False
nctId: NCT06315075 id: 657876 briefTitle: Dialectical Behavior Therapy for Adolescents With Self-harm and Suicidal Behavior- an Open Trial overallStatus: RECRUITING date: 2024-01-15 date: 2025-12-31 date: 2029-12-31 date: 2024-03-18 date: 2024-03-18 name: Haukeland University Hospital class: OTHER briefSummary: The goal of this pre-post-follow-up study is to examine how well the treatment Dialectical behavior therapy for adolescents (DBT-A) with a duration of 20 weeks for adolescents with self-harm and suicidal behavior works in routine clinical practice. The main questions it aims to answer are:
* to investigate whether pre-treatment factors can predict who will benefit from treatment conditions: Self-harm conditions: Suicidal Ideation conditions: Suicide and Self-harm studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single group, uncontrolled, pre-post-one year follow-up study primaryPurpose: TREATMENT masking: NONE maskingDescription: An independent evaluator will assess participants at post treatment and one year follow-up. Due to the single group design, the assessor will be aware that participants have received the intervention, but will not be involved in recruitment and treatment. count: 140 type: ESTIMATED name: Dialectical behavior therapy for adolescents (DBT-A) measure: Lifetime Parasuicide Count Interview measure: Number of participants in need of emergency department visits caused by suicidal behavior measure: Depressive symptom score measured by Short Mood and Feelings questionnaire (SMFQ) measure: Health related quality of life measured by SCREENing for and Promotion of Health Related Quality of Life in Children an Adolescents (Kidscreen 10) measure: Barriers to Treatment Participation Scale (BTPS) score measure: Perceived benefit of skills training in DBT-A measured by a study specific questionnaire. sex: ALL minimumAge: 13 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Dept. of child and adolescent psychiatry, Haukeland University Hospital status: RECRUITING city: Bergen zip: 5021 country: Norway name: Gro Janne H. Wergeland, MD, PhD role: CONTACT phone: +47 48176828 email: gneh@helse-bergen.no name: Anne Mari Syversen, Psychol role: CONTACT phone: +4755975000 email: anne.mari.syversen@helse-bergen.no lat: 60.39299 lon: 5.32415 hasResults: False
nctId: NCT06315062 id: CEC-UNIBE-07-2023 briefTitle: Efficacy of Rezum® in Reducing Prostate Volume overallStatus: COMPLETED date: 2020-01-01 date: 2022-12-31 date: 2023-12-31 date: 2024-03-18 date: 2024-03-18 name: Urología Costa Rica class: OTHER briefSummary: This study aimed to assess the efficacy of Rezum® water vapor therapy in reducing prostate volume in patients aged 40 years or older with Benign Prostate Hyperplasia (BPH) at UNIBE Hospital in Costa Rica. A retrospective analysis will be conducted on 289 patient records, focusing on prostate volume, International Prostate Symptom Score (IPSS), and urinary flow rate. Statistical analyses included two-sample mean comparisons, effect size estimation, and linear regression. conditions: Benign Hyperplasia of Prostate studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 289 type: ACTUAL measure: Prostate volume measure: International Prostate Symptome Score measure: Urinary flow rate sex: MALE minimumAge: 40 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital UNIBE city: San José zip: 11301 country: Costa Rica lat: 9.93333 lon: -84.08333 hasResults: False
nctId: NCT06315049 id: 2023-ENFPOD-2621979 briefTitle: Music Therapy to Reduce Anxiety in Community-Dwelling Individuals With Severe Mental Illness overallStatus: COMPLETED date: 2023-06-26 date: 2023-07-31 date: 2023-07-31 date: 2024-03-18 date: 2024-03-18 name: Universitat Politècnica de València class: OTHER name: University of Valencia briefSummary: This study aims to measure the effectiveness of the Music Therapy nursing intervention in reducing anxiety in outpatients diagnosed with severe mental illness (SMI) (bipolar disorder and schizophrenia). The intervention was structured over five weeks (ten 1-hour sessions, twice weekly). Objective measures (blood pressure, heart rate, and respiratory rate) and subjective measures (anxiety response and the subjective perception of relaxation) were taken before and after every session. conditions: Severe Mental Disorder conditions: Schizophrenia conditions: Bipolar Disorder conditions: Anxiety studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 14 type: ACTUAL name: Music therapy measure: IDARE test measure: SBP measure: DBP measure: HR measure: RR sex: ALL minimumAge: 35 Years maximumAge: 50 Years stdAges: ADULT facility: Universitat Politècnica de València city: Valencia zip: 46022 country: Spain lat: 39.46975 lon: -0.37739 hasResults: False
nctId: NCT06315036 id: 32/2021 briefTitle: Effects of Developmental Gymnastics on Preschoolers' Motor Skills acronym: GymKids overallStatus: COMPLETED date: 2021-09-05 date: 2021-09-10 date: 2022-05-10 date: 2024-03-18 date: 2024-03-18 name: University of Novi Sad class: OTHER briefSummary: Background: During childhood, physical activity (PA) is considered indispensable for developing motor skills through movement in the early stages of human development. Being active helps individuals develop fine and gross motor skills (GMS) by promoting an active lifestyle. Notably, this phase, characterized by regular PA and attaining motor competence, is associated with many health-related benefits. Early motor intervention programs have garnered attention for their positive influence on children's motor skills, as evidenced by various studies. A spectrum of more specialized methods is available alongside these general approaches, including programs designed to augment the time dedicated to general PA within school environments. Previous research has demonstrated the efficacy of incorporating experimental exercise interventions, grounded in enjoyable activities and game drills, into the curriculum, significantly improving children's basic motor skills. Many research articles have explored the impact of developmental gymnastics (DG) on children's fitness, indicating that gymnastics training can produce numerous beneficial outcomes for children's physical fitness.
Method and Materials: Three hundred preschool children were assigned to either a gender-balanced group participating in a DG exercise program (EG; n=99) or a control group (CG; n=121). While individuals in the CG followed three structured extracurricular physical activities per week in kindergarten, the EG participants received 60 minutes of the DG exercise program two days a week. The Test of Gross Motor Development-2 (TGMD-2) was used to assess GMS.
Aim: The study aimed to determine if participation in a structured DG program could improve GMS among preschool children compared to those in a group that attended extracurricular physical activities in a kindergarten. conditions: Motor Activity conditions: Child Development conditions: Exercise studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 300 type: ACTUAL name: Developmental gymnastics measure: Test of gross motor development (tgmd-2): Locomotor Skills - Run measure: Test of gross motor development (tgmd-2): Locomotor skills - Gallop measure: Test of gross motor development (tgmd-2): Locomotor skills - Hop measure: Test of gross motor development (tgmd-2): Locomotor skills - Leap measure: Test of gross motor development (tgmd-2): Locomotor skills - Horizontal jump measure: Test of gross motor development (tgmd-2): Locomotor skills - skip measure: Test of gross motor development (tgmd-2): Locomotor skills - slide measure: Test of gross motor development (tgmd-2): Object control skill- two-hand strike measure: Test of gross motor development (tgmd-2): Object control skill- stationary bounce measure: Test of gross motor development (tgmd-2): Object control skill- catch measure: Test of gross motor development (tgmd-2): Object control skill- kick measure: Test of gross motor development (tgmd-2): Object control skill- overhand throw measure: Test of gross motor development (tgmd-2): Object control skill- underhand roll measure: Sex measure: Date of birth measure: Weight measure: Height measure: Body Mass Index (BMI) measure: Adherence sex: ALL minimumAge: 4 Years maximumAge: 7 Years stdAges: CHILD facility: Faculty of sport and Physical Education, University of Novi Sad city: Novi Sad state: Vojvodina zip: 21000 country: Serbia lat: 45.25167 lon: 19.83694 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2024-03-07 uploadDate: 2024-03-13T15:29 filename: Prot_000.pdf size: 1944925 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2020-06-10 uploadDate: 2024-03-13T15:30 filename: ICF_001.pdf size: 147616 hasResults: False
nctId: NCT06315023 id: CP-0029 briefTitle: The Percutaneous Transmural Arterial Bypass -1 Study (Post Approval Registry) acronym: PTAB1 overallStatus: ENROLLING_BY_INVITATION date: 2023-10-06 date: 2028-06-07 date: 2032-06-07 date: 2024-03-18 date: 2024-03-26 name: Endologix class: INDUSTRY name: Fivos name: Massachusetts General Hospital name: Society for Vascular Surgery Patient Safety Organization briefSummary: The purpose of this post-market surveillance study will be to evaluate the real-world use of the DETOUR System in treated patients with symptomatic femoropopliteal lesions from 200 mm to 460 mm in length with chronic total occlusions (100 mm to 425 mm) or diffuse stenosis \> 70% who may be considered suboptimal candidates for surgical or alternative endovascular treatments. conditions: Peripheral Arterial Disease conditions: Symptomatic Femoropopliteal Lesions studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 450 type: ESTIMATED name: DETOUR System measure: Freedom from CD-TLR measure: Freedom from MAE sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: NYU Langone Medical Center city: New York state: New York zip: 10016 country: United States lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06315010 id: MedOPP662 id: CA127-1061 type: OTHER domain: Bristol-Myers Squibb GmbH & Co id: 2023-508112-35 type: EUDRACT_NUMBER briefTitle: REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis acronym: REPOSE overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2027-03 date: 2028-04 date: 2024-03-18 date: 2024-03-18 name: MedSIR class: OTHER name: Medical University of Vienna briefSummary: REPOSE is a phase II clinical trial exploring the safety and efficacy of repotrectinib in patients with non-small cell lung cancer (NSCLC) characterized by the presence of brain metastasis (BM) and whose tumors have mutated ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) gene. conditions: NSCLC conditions: Brain Metastases conditions: ROS1 Gene Rearrangement studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Repotrectinib measure: Intracranial Objective Response Rate (IC-ORR) measure: Clinical Benefit Rate (CBR) for intracranial (IC) lesions measure: Disease Control Rate (DCR) for IC lesions measure: Time to Response (TTR) for IC lesions measure: Duration of Response (DoR) for IC lesions measure: Objective Response Rate for extracranial (EC) and overall lesions (EC-ORR) measure: CBR for EC and overall lesions measure: DCR for EC and overall lesions measure: TTR for EC and overall lesions measure: DoR for EC and overall lesions measure: Best percentage of change in tumor burden measure: Progression-Free Survival (PFS) measure: Overall Survival (OS) measure: Neurologic function measure: Quality of life (QoL) with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-30) measure: QoL with the brain cancer specific questionnaire (QLQ-C20). measure: Safety and tolerability measure: Exploratory endpoint: Genetic studies using blood samples to investigate the potential association with clinical outcomes measure: Exploratory endpoint: ROS1 gene expression analysis using baseline tissue samples to investigate the potential association with clinical outcomes measure: Exploratory endpoint: Analysis of medical imaging to identify potential biomarkers associated with clinical outcomes sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06314997 id: 2013.34 briefTitle: Dynamic Changes in Circulating Tumour Cells Protein Expression acronym: Liquid-DRER2 overallStatus: RECRUITING date: 2019-01-14 date: 2024-12-17 date: 2027-12-18 date: 2024-03-18 date: 2024-03-18 name: Matteo's Friends class: OTHER briefSummary: This multicenter study, randomized, controlled of blood-based biomarker-driven targhet therapy. Patients were selectedm( at Hospital San Giovanni and Celio in Rome) according to CTCs results ( CTCs-guided managment performed at University Magna Graecia) or managed by the treating clinician according to standard pathological criteria (standard management). The participants were assigned to trial groups with the use of block randomization stratified according to the enrolling center location metropolitan) and tumor stage (T3 or T4). conditions: Recurrence Free Survival studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 150 type: ESTIMATED name: panitumumab (EGFR inhibitors) measure: The primary efficacy end point was recurrence- free survival at 12 months. sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Natalia Malara status: RECRUITING city: Germaneto zip: 88100 country: Italy lat: 38.88496 lon: 16.57673 hasResults: False
nctId: NCT06314984 id: A10040521 briefTitle: Jet Injectors Versus Conventional Anesthetic Technique in Children overallStatus: COMPLETED date: 2021-07-21 date: 2022-11-15 date: 2023-03-21 date: 2024-03-18 date: 2024-03-18 name: Mansoura University class: OTHER briefSummary: This clinical study was conducted to compare the needleless Comfort-in jet injector device and the conventional needle technique in terms of