hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06331130 id: 6363 briefTitle: Mesenteric Infiltration in Ovarian Cancer acronym: MIO overallStatus: RECRUITING date: 2024-03-01 date: 2025-06-30 date: 2025-12-31 date: 2024-03-26 date: 2024-03-26 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER name: Danube University Krems name: Institut du Cancer de Montpellier - Val d'Aurelle name: Ente Ospedaliero Cantonale, Ticino, Switzerland briefSummary: To evaluate if CT features at diagnosis in patients with HGSOC can be used to build an Artificial Intelligence model capable of discerning the pathological involvement of the mesentery, assessing the potential impediments for an optimal debulking surgery and predicting the development of resistance to platinum based chemotherapeutic agents. conditions: Ovary Cancer studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 510 type: ESTIMATED name: Computed Tomography measure: Preoperative Artificial Intelligence assisted CT-based evaluation measure: Evaluation of the Radiologist Assessment of the CT measure: Prediction of Platinum Resistance measure: Prediction of Progression Free Survival (PFS) and Overall Survival (OS) sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Advanced Radiology Center status: RECRUITING city: Roma zip: 00168 country: Italy name: Camilla Panico, MD role: CONTACT phone: +390630158637 email: camilla.panico@policlinicogemelli.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06331117 id: 3776 briefTitle: Effect of RAS/MAPK Pathway Hyperactivation on Growth' and Bone' Profile of the RASopathies acronym: 3776 overallStatus: RECRUITING date: 2021-04-22 date: 2021-12-22 date: 2026-04-22 date: 2024-03-26 date: 2024-03-26 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: Costello syndrome (CS) and cardio-facio cutaneous syndrome (CFCS) belongs to RASopathies, a group of multisystemic disorders caused by unregulated signalling through the RAS/MAPK pathway, an intracellular signalling pathway regulating multiple processes such as cellular proliferation, differentiation, survival, apoptosis and also contributing to oncogenesis. They share a recognizable facial appearance, aged appearance, growth delay, muscle-skeletal anomalies, heart defects, neuropsychological features, skin and ocular abnormalities, and cancer predisposition.
Even though life expectancy of individuals with CS and CFCS has increased in the last years due to the improvement of patients' care and a more effective prevention of comorbidities, some of the most challenging aspects impacting on everyday living such as growth failure, accelerate senescence and skeletal-muscle defects, still need to be fully understood. This statement underlies the need to improve clinical research protocols with more innovative techniques (multi-omics profiling) in order to better understand the effect of RAS/MAPK pathway hyperactivations on different systems and to define possible personalized treatments. conditions: RASopathy conditions: Costello Syndrome conditions: Noonan Syndrome conditions: Cardio-Facio-Cutaneous Syndrome studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 120 type: ESTIMATED name: Diagnostic test measure: Metabolomic profile of the RASopathies sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Woman and Child Health and Public Health, Fondazione Policlinico A. Gemelli, IRCCS status: RECRUITING city: Roma zip: 00168 country: Italy name: Chiara Leoni, MD, PhD role: CONTACT phone: 0039063381344 email: chiara.leoni@policlinicogemelli.it lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06331104 id: ChangyeZou briefTitle: Network Pharmacology Prediction: Mechanism Study of Puerarin in the Treatment of Giant Cell Tumors of Bone overallStatus: COMPLETED date: 2012-06-14 date: 2023-08-31 date: 2023-08-31 date: 2024-03-26 date: 2024-04-02 name: Changye Zou class: OTHER briefSummary: Based on network pharmacology analysis, this study aims to explore the potential therapeutic targets and molecular mechanisms of puerarin on giant cell tumor of bone (GCTB) genes. conditions: Giant Cell Tumors studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 145 type: ACTUAL name: gene expression levels measure: P27 expression levels measure: ESR1 expression levels sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Churong Yan city: Guangzhou state: Guangdong zip: 518010 country: China lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06331091 id: YuzuncuYıl2022/2 briefTitle: Physiotherapy and Reaction Time in Hemophilia overallStatus: COMPLETED date: 2022-12-10 date: 2024-01-19 date: 2024-01-19 date: 2024-03-26 date: 2024-04-02 name: Yuzuncu Yıl University class: OTHER briefSummary: This randomised controlled study was conducted to investigate the comprehensive physiotherapy combined with home exercises on individuals with hemophilic arthropathy in the lower extremity. There are two groups in the study: home exercises and comprehensive physiotherapy combined with home exercises. Is physiotherapy combined with home exercises superior to home exercises on joint health, bleeding frequency, reaction time, dynamic balance, muscle strength? The aim of this study is to increase the compliance of hemophilic individuals to physiotherapy and adapt home exercises to their lives with weekly sessions. conditions: Hemophilia Arthropathy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomised controlled study primaryPurpose: TREATMENT masking: NONE count: 21 type: ACTUAL name: Home exercise name: Manual therapy name: Neuromuscular electrical stimulation name: Supervised exercise measure: Hemophilia Joint Health Score measure: Reaction time sex: MALE minimumAge: 10 Years maximumAge: 32 Years stdAges: CHILD stdAges: ADULT facility: Van Yüzüncü Yıl University city: Van zip: 65080 country: Turkey lat: 38.49457 lon: 43.38323 hasResults: False
nctId: NCT06331078 id: 29.02.2024/45 briefTitle: Square Step Exercises in Healthy Young Adults overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2025-02-01 date: 2025-08-01 date: 2024-03-26 date: 2024-03-29 name: Fenerbahce University class: OTHER briefSummary: This study aims to compare the effectiveness of Square Stepping Exercise and aerobic exercise on cognitive function and physical fitness in young adults. Participants aged 18-30 with low physical activity levels will be randomly assigned to either the Square Stepping Exercise Group or Aerobic Exercise Group. Both interventions will be supervised by a physiotherapist, performed twice a week for 40 minutes over 4 weeks. Cognitive function will be assessed using various tests, including attention, short-term memory, and executive function evaluations. Physical fitness will be evaluated through jump tests and balance assessments. Blinded assessors will conduct evaluations at baseline and post-intervention in both groups to determine the impact of square stepping exercise and aerobic exercise on cognitive and physical health in young adults. conditions: Exercise conditions: Square Step Exercises conditions: Aerobic Exercise conditions: Cognitive Function conditions: Physical Fitness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 50 type: ESTIMATED name: Square Stepping Exercise training name: Aerobic Exercise Training measure: Schulte Grid Test measure: Stroop Test measure: Verbal Fluency Test measure: Digit Span Test measure: Vertical jump test measure: Horizontal jump test measure: Y Balance Test sex: ALL minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Marmara University city: Maltepe country: Turkey lat: 40.93567 lon: 29.15507 hasResults: False
nctId: NCT06331065 id: 69HCL21_1180 id: ID-RCB type: OTHER domain: 2023-A01756-39 briefTitle: Promoting Mental Health at Work Among Hospital Professionals acronym: PROMIND overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-03 date: 2025-06 date: 2024-03-26 date: 2024-03-26 name: Hospices Civils de Lyon class: OTHER briefSummary: Mental health is a state of well-being in which a person can realize his/her potential, cope with the normal stresses of life, work productively and contribute to his/her community. It refers to a continuum that extends from the promotion of well-being and the prevention of mental disorders to the treatment and rehabilitation of people suffering from these disorders.
Mindfulness meditation is one of the most extensively studied non-medication interventions in mental health. Declined in different modalities, its effects focus on improving resilience with efficacy on physical and mental well-being (stress, anxiety, burnout, affect), and their physiological corollary (cardiac and respiratory rhythms), acceptance of reality in stressful situations, reduced interpersonal conflict in emergencies and, more broadly, impact on relational behaviours (anti- and pro-social), teamwork. Managers also benefit, with a strengthening of the aspiration to lead, in a vision fully at the disposal of others.
nctId: NCT06331052 id: 23-2431 id: 1R01NS125386-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R01NS125386-01 briefTitle: 3-D Tractography FUS Ablation for Essential Tremor overallStatus: RECRUITING date: 2024-02-28 date: 2028-02-28 date: 2028-02-28 date: 2024-03-26 date: 2024-03-28 name: University of North Carolina, Chapel Hill class: OTHER name: Texas Tech University Health Sciences Center, El Paso name: University of Pittsburgh name: National Institute of Neurological Disorders and Stroke (NINDS) briefSummary: The investigators propose to advance Vim-FUSA (Ventral Intermediate Nucleus - Focused Ultrasound Ablation) with the support of 3-D tractography, a neuroimaging technique to visually represent nerve tracts within the brain. The investigators hypothesize that 3-D tractography Vim-FUSA will improve the Vim ablation compared to standard Vim-FUSA and prove safe and feasible in the clinical setting. The investigators also hypothesize that intraoperative magnetic resonance (i-MR) monitoring will differentiate ablated tissue from immediate perilesional edema and accurately predict the Vim-FUSA clinical outcomes. conditions: Essential Tremor studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 24 type: ESTIMATED name: MR-guided Focused Ultrasound Ablation measure: Number of Participants without Side Effects measure: Absolute Change in Tremor measure: Relative Change in Tremor measure: Number of Participants with Procedure-Related Side Effects measure: Relative Change in Tremor-Related Quality of Life measure: Number of Participants Who Are Satisfied with Treatment measure: Change in Tremor Based on Video Assessment measure: Change in Gait Based on Video Assessment sex: ALL minimumAge: 22 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of North Carolina at Chapel Hill status: RECRUITING city: Chapel Hill state: North Carolina zip: 27999 country: United States name: Mary Ann Barnett, MLS role: CONTACT phone: 919-966-8804 email: mary-ann_barnett@med.unc.edu name: Vibhor Krishna, MD, SM role: CONTACT phone: 919-445-2410 email: vibhor_krishna@med.unc.edu name: Vibhor Krishna, MD, SM role: PRINCIPAL_INVESTIGATOR lat: 35.9132 lon: -79.05584 hasResults: False
nctId: NCT06331039 id: CelalBayarU-5 briefTitle: The Effects of Pelvic Floor Muscle Training and Balance Exercises in Elderly People With Incontinence overallStatus: NOT_YET_RECRUITING date: 2024-04-05 date: 2024-04-05 date: 2024-07-30 date: 2024-03-26 date: 2024-03-27 name: Celal Bayar University class: OTHER name: Dokuz Eylul University name: Saglik Bilimleri Universitesi briefSummary: Pelvic floor muscle weakness is one of the most important causes of incontinence. There are many studies supporting that pelvic floor muscle training prevents incontinence and reduces symptom severity, and with A level of evidence, it is among the first in the conservative treatment of incontinence. Functional status and balance problems are common in elderly people with incontinence, and it is known that functional type incontinence is common. Elderly people with incontinence most often fall while trying to get to the toilet. Balance exercises are recommended for falls and balance problems.
The aim of this study is to examine the effects of pelvic floor muscle training and balance exercises on ankle muscle function, joint range of motion and balance in individuals aged 65 and over with urinary incontinence. conditions: Urinary Incontinence conditions: Pelvic Floor Muscle Weakness conditions: Muscle Weakness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 36 type: ESTIMATED name: PFMT name: PFMT+Balance measure: ankle muscle function measure: ankle range of motion measure: muscle strength measure: incontinence symptoms and severity measure: incontinence symptoms and severity measure: balance measure: bladdery diary measure: functional performance sex: ALL minimumAge: 65 Years maximumAge: 100 Years stdAges: OLDER_ADULT facility: Melda BAŞER SEÇER city: Mani̇sa state: Yunusemre zip: 45000 country: Turkey name: Melda BAŞER SEÇER, PhD role: CONTACT phone: +905547285453 email: melda.secer@cbu.edu.tr name: Özge ÇELİKER TOSUN, Assos. Prof. role: CONTACT phone: +905055252029 email: ozge.tosun@deu.edu.tr lat: 38.61202 lon: 27.42647 hasResults: False
nctId: NCT06331026 id: GenSci004-106 briefTitle: A Bioequivalence Study of Two Different PEG-rhGH Preparations. overallStatus: NOT_YET_RECRUITING date: 2024-04-07 date: 2024-05-31 date: 2024-11-30 date: 2024-03-26 date: 2024-03-26 name: Changchun GeneScience Pharmaceutical Co., Ltd. class: INDUSTRY briefSummary: The purpose of this study is to investigate whether PEG-rhGH with new preparation is bioequivalent to PEG-rhGH with present preparation. conditions: Pediatric Growth Hormone Deficiency (PGHD) studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: NONE count: 87 type: ESTIMATED name: PEG-rhGH with new preparation (T) name: PEG-rhGH with present preparation (R) measure: Pharmacokinetics (Peak Plasma Concentration (Cmax) ) of PEG-rhGH with present and new preparation measure: Pharmacokinetics (Area under the concentration-time curve from time zero to time infinity (AUC0-inf)) of PEG-rhGH with present and new preparation measure: Pharmacokinetics (Area under the concentration-time curve from time zero to the time of the last quantifiable (AUC0- last )) of PEG-rhGH with present and new preparation measure: Safety and tolerability（Number of participants with treatment-related adverse events） measure: Anti-drug antibody (Number of Participants with positive ADA) sex: MALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Chengdu Xinhua Hospital city: Chengdu state: Sichuan zip: 610000 country: China name: Xiaolan Yong, Doctor role: CONTACT phone: +86-28-60212136 email: yongxlan@126.com lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06331013 id: IEO 1872 briefTitle: CyberKnife Ultra-hypofractionated SBRT for Localized PROStatE cancEr acronym: PRO-SPEED overallStatus: RECRUITING date: 2023-02-20 date: 2024-12-31 date: 2029-12-31 date: 2024-03-26 date: 2024-03-26 name: European Institute of Oncology class: OTHER briefSummary: This is a prospective observational study. The study will proceed with the enrollment of 60 patients in 2 years. he aim of the present study is to evaluate effectiveness of ultra-hypofractionated (UH) CyberKnife Stereotactic Body Radiation Therapy treatment on the whole prostate gland plus Simultaneous integrated boost (SIB) to the dominant intraprostatic lesions (DIL(s) in intermediate-unfavourable to high-risk Prostate Cancer (PCa) patients. conditions: Prostate Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: CyberKnife ultra-hypofractionated SBRT measure: Number of Participants with Acute GU and GI toxicities (RTOG) measure: Number of Participants with Late GU and GI toxicities (RTOG) measure: Evaluation of patient-reported toxicity measure: Evaluation of patient-reported quality of life sex: MALE minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: European Institute of Oncology status: RECRUITING city: Milan country: Italy name: Barbara Alicja Jereczek role: CONTACT lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06331000 id: 9248 briefTitle: Effect of One Year Elexacaftor-tezacaftor-ivacaftor Treatment acronym: DIATRIM overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-03 date: 2025-03 date: 2024-03-26 date: 2024-03-26 name: University Hospital, Strasbourg, France class: OTHER briefSummary: The development of CFTR (cystic fibrosis conductance transmembrane regulator) modulators for people with cystic fibrosis (pwCF) and eligible for these treatments is a true therapeutic revolution. The major beneficial effect of CFTR modulators (CFTRm) on pulmonary function and the reduction of pulmonary exacerbations should have a considerable impact on the quality of life and patient's life expectancy. Data on the impact of CFTRm on glucose tolerance abnormalities are still very fragmentary. The investigators can think that their use, earlier and earlier in the history of the disease, will transform the evolutionary trajectories of patients on the respiratory, nutritional and metabolic levels.
Diabetes represents a major challenge in the management of pwCF because it is a factor in morbidity and mortality at all stages of the disease, from children to patients with terminal respiratory failure requiring lung transplantation. Early abnormalities in glucose tolerance observed in childhood, before the stage of diabetes, are also associated with poor pulmonary and nutritional outcomes. Experimental data suggest a positive effect of CFTRm on insulin secretion. However, investigators do not currently know the impact of CFTRm in patients with very early glucose disorders or at the stage of diabetes treated with insulin. Recently continuous glucose measurement (CGM) devices represent very effective tools for assessing abnormalities in glucose tolerance before the stage of diabetes and for monitoring patients treated with insulin. conditions: Cystic Fibrosis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 100 type: ESTIMATED name: elexacaftor-tezacaftor-ivacaftor treatment measure: Evaluate time in range of blood glucose variation >140 mg/dl during 2 weeks in a cohort of adult patients treated for one year with elexacaftor-tezacaftor-ivacaftor measure: Evaluate other CGM parameters : time in range of blood glucose >180mg/dl ; >140mg/dl ; <70mg/dl ; 70-180 mg/dl ; 70-140mg/dl measure: Marker of metabolic status: HbA1c (mmol/l) measure: Marker of metabolic status: HbA1c (%) measure: Marker of metabolic status: C-Peptid (µg/L) measure: Marker of metabolic status: C-Peptid (nmol/L) measure: Markers of nutritional status: Evaluation of weight monitoring (kg) measure: Markers of nutritional status: Body Mass Index (BMI) measure: Diabetes treatment (assess insulin needs) : mean glucose value per day (mg/dl) measure: Assessment of respiratory function parameters : number of IV antibiotics measure: Number patients with severe hypoglycaemia and serious adverse events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06330987 id: 15110_MANNELLA briefTitle: Fetal Autonomic Nervous sysTem Evaluation acronym: FANTE overallStatus: RECRUITING date: 2019-08-13 date: 2025-09-28 date: 2025-12-28 date: 2024-03-26 date: 2024-03-26 name: University of Pisa class: OTHER name: Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy briefSummary: The autonomic nervous system (ANS) is involved in cardiovascular, metabolic and cognitive processes, so its study in the fetus can provide relevant functional diagnostic and prognostic information. In particular, the study of the fetal ANS allows us to understand the degree of nervous maturation reached by the fetus and any developmental disorders that could have an impact on the cardiovascular characteristics of the fetus.
Participants will be recruited during ultrasound visits, information sessions, and hospitalizations after signing informed consent. conditions: Pregnancy Related conditions: Pregnancy Disease conditions: Pregnancy Complications conditions: Pre-Eclampsia conditions: Gestational Diabetes conditions: ECG Electrode Site Reaction conditions: Fetal Growth Retardation conditions: Fetal Complications studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: PROSPECTIVE count: 186 type: ESTIMATED name: electrocardiograph measure: Fetal Autonomic Nervous sysTem Evaluation (FANTE) measure: Maternal Assesment measure: Obstetric Complications and mode of Delivery sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Azienda Ospedaliera Universitaria Pisana status: RECRUITING city: Pisa zip: 56126 country: Italy name: Paolo Mannella, MD. PhD. role: CONTACT phone: 0039.050.993523 email: paolo.mannella@unipi.it lat: 43.70853 lon: 10.4036 hasResults: False
nctId: NCT06330974 id: FinnATOPY briefTitle: Allergy, Asthma, and Atopic Eczema in Finland acronym: FinnATOPY overallStatus: NOT_YET_RECRUITING date: 2024-10 date: 2032-12 date: 2034-12 date: 2024-03-26 date: 2024-03-26 name: Tampere University class: OTHER name: Professor Lauri Lehtimäki name: Professor Mika Mäkelä name: Professor Sanna Toppila-Salmi name: Professor Ilkka Junttila briefSummary: The summary is available at --\> https://www.finnatopy.fi/summary conditions: Asthma conditions: Asthma in Children conditions: Allergy conditions: Rhinitis, Allergic conditions: Atopic Dermatitis conditions: Allergen Immunotherapy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 2000000 type: ESTIMATED name: No intervention measure: Epidemiology of atopic diseases and allergic sensitization profiles in Finland measure: Burden of atopic diseases (allergies, asthma, and atopic eczema) as well as comorbidities in Finland measure: Evaluate and improve the current use of diagnostic tests for atopic diseases measure: Use and effectiveness of allergen immunotherapy in real world setting measure: Direct and indirect costs related to atopic diseases and comorbidities sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Tampere University city: Tampere country: Finland lat: 61.49911 lon: 23.78712 hasResults: False
nctId: NCT06330961 id: 2023-MED-2756299 briefTitle: Effects of Different Kinds of Exercise in Low Back Pain overallStatus: RECRUITING date: 2024-01-08 date: 2024-06 date: 2025-02 date: 2024-03-26 date: 2024-03-26 name: University of Valencia class: OTHER briefSummary: Low back pain is considered one of the great global challenges in public health due to its high prevalence. Exercise have been shown to cause an increase in pain thresholds, through the effect known as exercise-induced hypoalgesia. Little is known about exercise-induced hypoalgesia induced by different modalities of exercise in low back pain, and its possible effects in lumbopelvic biomechanics.