nctId: NCT06308406 id: HRS-1167-201-Bev briefTitle: A Phase Ib/II Clinical Study of HRS-1167 in Combination With Bevacizumab in Patients With Recurrent Ovarian Cancer overallStatus: RECRUITING date: 2024-03-15 date: 2025-10 date: 2025-10 date: 2024-03-13 date: 2024-04-11 name: Jiangsu HengRui Medicine Co., Ltd. class: INDUSTRY briefSummary: This study is a multicenter, open-label Phase Ib/II clinical trial to observe and evaluate the safety, tolerability and pharmacokinetics of HRS-1167 in combination with bevacizumab in patients with recurrent ovarian cancer mechanical characterization and preliminary evaluation of the efficacy of HRS-1167 in combination with bevacizumab in patients with recurrent ovarian cancer. conditions: Recurrent Ovarian Cancer studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 54 type: ESTIMATED name: Bevacizumab； HRS-1167 measure: The number of subjects with dose-limiting toxicity (DLT) measure: Determination of Recommended Phase II dose (RP2D) measure: Objective Response Rate (ORR) measure: Disease Control Rate (DCR) measure: Duration of Response (DoR) measure: Progression free Survival (PFS) measure: Overall Survival (OS) measure: Time To Response(TTR) sex: FEMALE minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: First Affiliated Hospital of University of Science and Technology of China status: NOT_YET_RECRUITING city: Hefei state: Anhui zip: 230002 country: China name: Ying Zhou role: PRINCIPAL_INVESTIGATOR lat: 31.86389 lon: 117.28083 facility: Cancer Hospital Chinese Academy of Medical Sciences status: NOT_YET_RECRUITING city: Beijing state: Beijing zip: 100021 country: China name: Lingying Wu role: PRINCIPAL_INVESTIGATOR lat: 39.9075 lon: 116.39723 facility: Beijing Cancer Hospital status: NOT_YET_RECRUITING city: Beijing state: Beijing zip: 100142 country: China name: Hong Zheng role: PRINCIPAL_INVESTIGATOR lat: 39.9075 lon: 116.39723 facility: Chongqing University Cancer Hospital status: NOT_YET_RECRUITING city: Chongqing state: Chongqing zip: 400000 country: China name: Yu Huang role: PRINCIPAL_INVESTIGATOR lat: 29.56278 lon: 106.55278 facility: The First Affiliated Hospital of Chongqing Medical University status: NOT_YET_RECRUITING city: Chongqing state: Chongqing zip: 400016 country: China name: Junying Tang role: PRINCIPAL_INVESTIGATOR lat: 29.56278 lon: 106.55278 facility: Guangxi Medical University Affiliated Tumor Hospital status: NOT_YET_RECRUITING city: Nanning state: Guangxi zip: 530022 country: China name: He Wang role: PRINCIPAL_INVESTIGATOR lat: 22.81667 lon: 108.31667 facility: The Fourth Hospital of Hebei Medical University status: NOT_YET_RECRUITING city: Shijiazhuang state: Hebei zip: 050001 country: China name: Hui Zhang role: PRINCIPAL_INVESTIGATOR lat: 38.04139 lon: 114.47861 facility: Harbin Medical University Cancer Hospital status: NOT_YET_RECRUITING city: Harbin state: Heilongjiang zip: 150001 country: China name: Ge Lou role: PRINCIPAL_INVESTIGATOR lat: 45.75 lon: 126.65 facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology status: NOT_YET_RECRUITING city: Wuhan state: Hubei zip: 430030 country: China name: Qinglei Gao role: PRINCIPAL_INVESTIGATOR lat: 30.58333 lon: 114.26667 facility: Hunan Cancer Hospital status: RECRUITING city: Changsha state: Hunan zip: 410013 country: China name: Jing Wang role: PRINCIPAL_INVESTIGATOR lat: 28.19874 lon: 112.97087 facility: Liaoning Cancer Hospital status: NOT_YET_RECRUITING city: Shenyang state: Liaoning zip: 110042 country: China name: Danbo Wang role: PRINCIPAL_INVESTIGATOR lat: 41.79222 lon: 123.43278 facility: Qilu Hospital of Shandong University status: NOT_YET_RECRUITING city: Jinan state: Shandong zip: 250000 country: China name: Hualei Bu role: PRINCIPAL_INVESTIGATOR lat: 36.66833 lon: 116.99722 facility: Shandong First Medical University Affiliated Cancer Hospital status: NOT_YET_RECRUITING city: Jinan state: Shangdong zip: 250117 country: China name: Liang Chen role: PRINCIPAL_INVESTIGATOR lat: 36.66833 lon: 116.99722 facility: Shanxi Provincial Cancer Hospital status: NOT_YET_RECRUITING city: Taiyuan state: Shanxi zip: 030006 country: China name: Hongwei Zhao role: PRINCIPAL_INVESTIGATOR lat: 37.86944 lon: 112.56028 facility: Sichuan Cancer Hospital status: NOT_YET_RECRUITING city: Chengdu state: Sichuan zip: 610042 country: China name: Guonan Zhang role: PRINCIPAL_INVESTIGATOR lat: 30.66667 lon: 104.06667 facility: Tianjin Cancer Hospital status: NOT_YET_RECRUITING city: Tianjin state: Tianjin zip: 300000 country: China name: Ke Wang role: PRINCIPAL_INVESTIGATOR lat: 39.14222 lon: 117.17667 facility: Yunnan Cancer Hospital status: NOT_YET_RECRUITING city: Kunming state: Yunnan zip: 650118 country: China name: Hongying Yang role: PRINCIPAL_INVESTIGATOR lat: 25.03889 lon: 102.71833 facility: Zhejiang Cancer Hospital status: NOT_YET_RECRUITING city: Hangzhou state: Zhejiang zip: 310005 country: China name: Tao Zhu role: PRINCIPAL_INVESTIGATOR lat: 30.29365 lon: 120.16142 hasResults: False