nctId: NCT06365060 id: 00003143 id: R01CA279808 type: NIH link: https://reporter.nih.gov/quickSearch/R01CA279808 briefTitle: Screening for AL Amyloidosis in Smoldering Multiple Myeloma overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2029-02-27 date: 2029-02-27 date: 2024-04-15 date: 2024-04-15 name: Tufts Medical Center class: OTHER name: National Cancer Institute (NCI) briefSummary: In this multicenter study, we will recruit 400 patients 40 years of age or older at 15 centers with a diagnosis of smoldering multiple myeloma (SMM), a group of patients for whom standard of care is observation not treatment. The main goal of this study is to screen for the diagnosis of light-chain amyloidosis (AL) before the onset of symptomatic disease and to develop a training set for a likelihood algorithm. conditions: Smoldering Multiple Myeloma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 400 type: ESTIMATED measure: Creating a network to enroll patients on a collaborative study requiring marrow and blood specimens, to collect data for a training set of likelihood statistics and to plan a future validation study. measure: Validating an NGS assay that identifies IGLV genes in clonal plasma cells sex: ALL minimumAge: 40 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Alabama Hospital city: Birmingham state: Alabama zip: 35233 country: United States name: Susan Bal, MD role: PRINCIPAL_INVESTIGATOR lat: 33.52066 lon: -86.80249 facility: Cedars-Sinai Medical Center city: Los Angeles state: California zip: 90048 country: United States name: Robert Vescio, MD role: PRINCIPAL_INVESTIGATOR lat: 34.05223 lon: -118.24368 facility: University of California, Irvine city: Orange state: California zip: 92868 country: United States name: Lisa Lee, MD role: PRINCIPAL_INVESTIGATOR lat: 33.78779 lon: -117.85311 facility: University of California, San Francisco city: San Francisco state: California zip: 94143 country: United States name: Tom Martin, MD role: PRINCIPAL_INVESTIGATOR lat: 37.77493 lon: -122.41942 facility: Cleveland Clinic Florida, Weston Hospital city: Weston state: Florida zip: 33331 country: United States name: Chakra Chaulagain, MD role: PRINCIPAL_INVESTIGATOR lat: 26.10037 lon: -80.39977 facility: Tufts Medical Center city: Boston state: Massachusetts zip: 02111 country: United States name: Denis Toskic, BS role: CONTACT phone: 617-636-5907 email: denis.toskic@tuftsmedicine.org name: Raymond Comenzo, MD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Dana-Farber Cancer Institute city: Boston state: Massachusetts zip: 02215 country: United States name: Giada Bianchi, MD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 facility: Columbia University Medical Center city: New York state: New York zip: 10032 country: United States name: Suzanne Lentzsch, MD role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 facility: Memorial Sloan Kettering Cancer Center city: New York state: New York zip: 10065 country: United States name: Heather Landau, MD role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 facility: Atrium Health Levine Cancer Institute city: Charlotte state: North Carolina zip: 28204 country: United States name: Cindy Varga, MD role: PRINCIPAL_INVESTIGATOR lat: 35.22709 lon: -80.84313 facility: UNC Lineberger Comprehensive Cancer Center city: Durham state: North Carolina zip: 27705 country: United States name: Sascha Tuchman, MD role: PRINCIPAL_INVESTIGATOR lat: 35.99403 lon: -78.89862 facility: UT Southwestern, Harold C. Simmons Comprehensive Cancer Center city: Dallas state: Texas zip: 75390 country: United States name: Gurbakhash Kaur, MD role: PRINCIPAL_INVESTIGATOR lat: 32.78306 lon: -96.80667 facility: University of Utah, Huntsman Cancer Hospital city: Salt Lake City state: Utah zip: 84112 country: United States name: Amandeep Godara, MD role: PRINCIPAL_INVESTIGATOR lat: 40.76078 lon: -111.89105 facility: VCU Medical Center city: Richmond state: Virginia zip: 23219 country: United States name: Hashim Mann, MD role: PRINCIPAL_INVESTIGATOR lat: 37.55376 lon: -77.46026 hasResults: False