hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06268210 id: 4-2023-1546 briefTitle: Neoadjuvant Lazertinib With or Without Chemotherapy for Patients With EGFR-mutated Resectable Non-small Cell Lung Cancer acronym: NeoLazer overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-06 date: 2028-06 date: 2024-02-20 date: 2024-02-20 name: Yonsei University class: OTHER briefSummary: In the randomized, multicenter Phase II clinical trial, we aim to evaluate the efficacy and safety of Lazertinib monotherapy or the combination of Lazertinib and cytotoxic chemotherapy as neoadjuvant therapy in patients with resectable, treatment-naive EGFR-mutant (exon 19 deletion or exon 21 L858R) non-small cell lung cancer, ranging from clinical stage IB to IIIB. The study is designed to assess the impact on pathological response, as well as effectiveness and safety considerations. conditions: Non-small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 160 type: ESTIMATED name: Lazertinib+Pemetrexed+Carboplatin name: Lazertinib measure: Primary pathological response measure: Surgical Resection Methods (Segmentectomy or Lobectomy) measure: Pathologic Complete Response measure: Objective Response Rate measure: Event-Free Survival measure: Disease-Free Survival measure: Overall Survival measure: Number of patients with Adverse events according to CTCAE v5.0 sex: ALL minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Severance hospital city: Seoul country: Korea, Republic of name: Hye Ryun Kim role: CONTACT phone: 82-2-2228-8125 email: nobelg@yuhs.ac lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06268197 id: IRB23-0329 briefTitle: Interoception-Based Yoga for Chronic Pain overallStatus: RECRUITING date: 2024-02-16 date: 2024-12-30 date: 2024-12-30 date: 2024-02-20 date: 2024-02-20 name: University of Illinois at Urbana-Champaign class: OTHER briefSummary: The purpose of this research is to examine the feasibility and acceptability of an interoception-based yoga program for chronic pain. Interoception involves your ability to feel sensations in your body (such as your heartbeat or muscle tension) as well as how you think about and interpret those sensations. Interoception may be an important component of chronic pain and the research team is studying whether yoga can change how you feel, think about, and interpret sensations in your body. conditions: Chronic Pain studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 32 type: ESTIMATED name: Yoga Intervention measure: Feasibility measure: Acceptability measure: Interoceptive Sensibility measure: PROMIS Pain Interference measure: Interoceptive Accuracy measure: Mindfulness measure: PROMIS Pain Intensity measure: Quality of Life measure: Spiritual Wellbeing measure: Pain Impact sex: ALL minimumAge: 18 Years maximumAge: 64 Years stdAges: ADULT facility: University of Illinois Urbana-Champaign status: RECRUITING city: Urbana state: Illinois zip: 61801 country: United States name: Project Coordinator role: CONTACT phone: 217-265-0741 email: svoss2@illinois.edu name: Neha P Gothe, PhD role: PRINCIPAL_INVESTIGATOR name: Steven Petruzzello, PhD role: SUB_INVESTIGATOR lat: 40.11059 lon: -88.20727 hasResults: False
nctId: NCT06268184 id: omega3 in oxidative stress briefTitle: Effect of Omega 3 on Oxidative Stress and Nutritional Status of Children on Regular Dialysis overallStatus: RECRUITING date: 2021-10-04 date: 2024-03-01 date: 2024-04-01 date: 2024-02-20 date: 2024-02-20 name: Tanta University class: OTHER briefSummary: evaluaion the effects of oral omega-3 supplementation on nutritional status and oxidative stress in pediatric patients with end stage renal disease on regular hemodialysis conditions: Oxidative Stress studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: group 1: 30 children with ESRD receive omega 3 supplementation group 2:15 children with ESRD receive lpacebo primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: PARTICIPANT count: 45 type: ESTIMATED name: D3 LAB SYRUP name: placebo capsule measure: decrease oxidative stress measure: increase antioxidant activity measure: improvement of nutritional status assessed by anthropometric measurements. measure: mid upper arm circumference in centimeters measure: triceps skin fold thickness in millimeter's measure: improvement of nutritional status assessed by Bioelectrical Inbody Analysis(BIA) measure: improvement of nutritional status assessed by Bioelectrical Inbody Analysis(BIA) measure: improvement of nutritional status assessed by Bioelectrical Inbody Analysis(BIA) measure: improvement of nutritional status assessed by Bioelectrical Inbody Analysis(BIA) measure: improvement of nutritional status assessed by Bioelectrical Inbody Analysis(BIA) measure: improvement of nutritional status assessed by laboratory investigations. measure: s. ionized calcium level measure: s.phosphorus level measure: alkaline phosphatase level measure: parathormone hormone level measure: 25(oh)vitamin D level sex: ALL minimumAge: 6 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Faculty of Medicine status: RECRUITING city: Tanta state: Gharbia country: Egypt name: Noha sayed ahmed, M.Sc role: CONTACT phone: 01016919217 phoneExt: 01097722167 email: noooooha1990@gmail.com name: rasha gamal elshafaay, MD role: CONTACT phone: 01227405988 phoneExt: 01114277784 email: rashagamal1978@gmail.com lat: 30.78847 lon: 31.00192 hasResults: False
nctId: NCT06268171 id: 2023_0214 id: 2023-A02390-45 type: OTHER domain: ANSM briefTitle: Ultrasound Assessment of Rectus Femoris Cross-sectionnal Area Following Lung Transplantation acronym: EchoSS-TP overallStatus: NOT_YET_RECRUITING date: 2024-03-04 date: 2025-09-04 date: 2025-11-05 date: 2024-02-20 date: 2024-02-20 name: Hopital Foch class: OTHER briefSummary: In France, the profile of patients receiving lung transplants has changed in recent years, mainly due to the advent of treatment for cystic fibrosis. This progress has led to an evolution in the patient profile, with an increase in cases of pulmonary fibrosis or COPD, and an increase in the average age of patients. In these older patients, sarcopenia, a condition characterized by loss of muscle mass, is a major concern, as it exacerbates morbidity and mortality.
Muscle ultrasound, a simple, non-invasive technique, is already used to assess muscle function in intensive care patients. This study aims to evaluate the use of ultrasound to measure muscle loss in lung transplant patients, in particular by examining the rectus femoris muscle. Objectives include observing variations in the surface area of the rectus femoris muscle before and after transplantation, identifying factors influencing this variation, and exploring its relationship with post-transplant morbidity.
In summary, this study seeks to better understand muscle loss in lung transplant patients using ultrasound, in order to identify risk factors and guide the development of post-transplant rehabilitation strategies. conditions: Lung Transplant conditions: Physiotherapy conditions: Sarcopenia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 42 type: ESTIMATED name: ultrasound measurement of the cross-sectional area of the rectus femoris measure: Evaluation of the change at D7 in the cross-sectional area of the rectus femoris following lung transplantation measure: Measure change in CSA-RF at D7 according to LT pattern measure: Evaluate the relationship between length of stay in intensive care unit and variation in CSA-RF at D7 measure: Determine the relationship between CSA-RF at D-1 and Body Mass Index sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06268158 id: 2023/45 briefTitle: The Effect of Eye Mask and Music on Sleep Quality and Delirium in Patients Monitored in Intensive Care Unit overallStatus: RECRUITING date: 2023-04-01 date: 2024-04-01 date: 2024-06-01 date: 2024-02-20 date: 2024-02-20 name: TC Erciyes University class: OTHER briefSummary: After abdominal surgery, most patients experience problems such as respiratory complications, surgical wound infection, cardiac problems, renal failure, delirium, and insomnia, along with surgical trauma and underlying comorbidities. Postoperative delirium (POD) is an adverse postoperative complication that can occur in patients of all ages, from children to the elderly. Effective non-pharmacological treatment approaches for delirium include using an orientation board, calendar, clock, ensuring hydration, improving sleep quality, therapeutic activities, providing companionship of family members, and building private rooms. This study will be conducted as a randomized controlled and experimental study to determine the effect of eye patch and music on sleep quality and delirium in patients followed after abdominal surgery in the surgical intensive care unit.
During the data collection phase, the Patient Information Form, Richard-Campbell Sleep Scale, Nursing Delirium Screening Scale and Richmond Agitation-Sedation Scale, will be used. conditions: Abdominal Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 34 type: ESTIMATED name: Eye patch measure: Richard-Campbell Sleep Scale measure: Nursing Delirium Screening Scale measure: Richmond Agitation-Sedation Scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Erciyes University status: RECRUITING city: Kayseri state: Talas zip: 38080 country: Turkey name: Yeliz Sürme, PhD role: CONTACT phone: +0905532051130 email: yelizsurme@erciyes.edu.tr name: Tuğçe TOPAL role: CONTACT phone: +9005075698312 email: tugcetopal5@gmail.com name: Tuğçe TOPAL, Msn role: PRINCIPAL_INVESTIGATOR name: Yeliz SÜRME, PhD role: PRINCIPAL_INVESTIGATOR lat: 38.73222 lon: 35.48528 hasResults: False
nctId: NCT06268145 id: EC0006 briefTitle: ECC5004 RBA FE Study in Healthy Participants overallStatus: RECRUITING date: 2024-02-06 date: 2024-03-30 date: 2024-03-30 date: 2024-02-20 date: 2024-02-20 name: Eccogene class: INDUSTRY briefSummary: This study is a Phase 1, open-label, randomized, single dose, fixed sequence, crossover study designed to compare the relative bioavailability of 50 mg ECC5004 current tablet formulation (F1) and 50 mg ECC5004 new tablet formulation (F2) under fasted and fed conditions in healthy participants conditions: Type 2 Diabetes Mellitus studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 14 type: ESTIMATED name: ECC5004 measure: ECC5004 PK parameters: AUC0-tlast measure: ECC5004 PK parameters: AUC0-inf measure: ECC5004 PK parameters: Cmax measure: ECC5004 PK parameters: tmax measure: Number of participants with adverse events, with abnormal laboratory test results, abnormal ECGs, abnormal vital signs, and abnormal physical examinations measure: ECC5004 PK parameters: AUC0-tau measure: ECC5004 PK parameters: AUC 0-24 measure: ECC5004 PK parameters: tlag measure: ECC5004 PK parameters: t1/2 measure: ECC5004 PK parameters: CL/F measure: ECC5004 PK parameters: AUC(extr) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Eccogene Investigational Site status: RECRUITING city: Anaheim state: California zip: 92801 country: United States name: Eccogene role: CONTACT lat: 33.83529 lon: -117.9145 hasResults: False
nctId: NCT06268132 id: MLS90 briefTitle: Longevity in Russia overallStatus: RECRUITING date: 2019-12-25 date: 2024-12-31 date: 2025-12-31 date: 2024-02-20 date: 2024-02-22 name: Center for Strategic Planning, of the Federal Medical and Biological Agency class: OTHER name: Pirogov Russian National Research Medical University briefSummary: This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia.
The study is expected to result in the development of a panel of markers of healthy longevity and/or a model of healthy aging based on the analysis of all factors under consideration. conditions: LONGEVITY 1 conditions: Frailty conditions: Aging conditions: Age-related Cognitive Decline conditions: Aging Disorder studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 4000 type: ESTIMATED measure: Mortality among long-living adults measure: Morbidity among long-living adults measure: Aging phenotypes measure: Social, economic, and medical- history-related determinants measure: Genetic determinants measure: Epigenetic determinants measure: Metagenomic determinants sex: ALL minimumAge: 90 Years stdAges: OLDER_ADULT facility: RUSSIAN CLINICAL AND RESEARCH CENTER OF GERONTOLOGY, Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation status: RECRUITING city: Moscow zip: 129226 country: Russian Federation name: Irina D. Strazhesko, M.D., Ph.D role: CONTACT phone: +7 (499) 187-64-67 email: Istrazhesko@gmail.com lat: 55.75222 lon: 37.61556 hasResults: False
nctId: NCT06268119 id: MustafaKU-SBF-GKS-01 briefTitle: Effectiveness of Delirium Care Protocol After Cardiac Surgery overallStatus: COMPLETED date: 2023-03-06 date: 2023-05-15 date: 2023-05-22 date: 2024-02-20 date: 2024-02-20 name: Gonul Kara Soylemez class: OTHER briefSummary: This study was conducted as a quasi-experimental study to determine the effectiveness of the postoperative delirium prevention, diagnosis and intervention protocol in patients monitored in the intensive care unit after cardiac surgery. conditions: Delirium, Postoperative studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The control group received standard care. The intervention group received care in line with postoperative delirium prevention, diagnosis, and intervention. primaryPurpose: PREVENTION masking: NONE count: 64 type: ACTUAL name: training nurses and caring for patients to prevent, diagnose, and intervene in postoperative delirium. measure: Confusion Assessment Scale in the Intensive Care Unit (CAM-ICU) measure: Glasgow Coma Scale (GCS) measure: Richmond Agitation-Sedation Scale (RASS) measure: Information Assessment Form for Postoperative Delirium (Pretest-Posttest) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Antalya Training and Research Hospital city: Antalya state: Center zip: 07000 country: Turkey lat: 36.90812 lon: 30.69556 hasResults: False
nctId: NCT06268106 id: IRB N/A briefTitle: Graphic Novel for Patients Undergoing EUS-FNB overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-07-30 date: 2024-08-01 date: 2024-02-20 date: 2024-02-20 name: The Mediterranean Institute for Transplantation and Advanced Specialized Therapies class: OTHER briefSummary: Endoscopy with endoscopic ultrasound (EUS) is a primary technique for diagnosing and treating severe pancreatic disorders. However, the procedure can cause fear and anxiety in patients, especially when a biopsy is involved. Graphic medicine, a form of visual storytelling that explores narratives of healthcare, is being used to alleviate this anxiety.
This study is conducted according to the principles of the Declaration of Helsinki regarding experimentation involving human subjects, and written informed consent will be obtained from all participants before enrollment. conditions: Anxiety conditions: Pancreatic Cancer conditions: Pancreatic Cystic Lesions conditions: Stress studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Graphic novel will be visualized by interventional group before EUS-FNB primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE whoMasked: CARE_PROVIDER count: 50 type: ESTIMATED name: Graphic novel visualization measure: Anxiety and stress level according to BAI measure: Anxiety and stress level according to mASS-14 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Irccs - Ismett city: Palermo state: PA zip: 90127 country: Italy name: Giacomo Emanuele Maria Rizzo, MD role: CONTACT phoneExt: +393406602502 email: g.rizzo.gr@gmail.com name: Ilaria Tarantino, MD role: PRINCIPAL_INVESTIGATOR name: Giacomo Emanuele Maria Rizzo, MD role: PRINCIPAL_INVESTIGATOR name: Mario Traina, MD role: PRINCIPAL_INVESTIGATOR lat: 38.13205 lon: 13.33561 hasResults: False
nctId: NCT06268093 id: XWTETS briefTitle: The Therapeutic Effect of Thalidomide in Syringomyelia overallStatus: RECRUITING date: 2024-02 date: 2027-02 date: 2028-02 date: 2024-02-20 date: 2024-02-20 name: Xuanwu Hospital, Beijing class: OTHER briefSummary: Purpose: This phase II clinical trial aims to evaluate the indications, therapeutic effects and side effects of thalidomide in refractory syringomyelia.
Primary outcome measure: The primary endpoint is the change of ASIA at week 12. The clinical efficacy is defined as ASIA increase ≥ 1 at week 12, as compared with that before thalidomide usage. conditions: Syringomyelia conditions: Thalidomide studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Thalidomide measure: ASIA Score measure: syringomyelia remission measure: The evoked electromyographic signal (eEMG) potential measure: Visual Analog Scale (VAS) measure: Klekamp and Sammi syringomyelia scale measure: modified Japanese Orthopaedic Association Scores (mJOA) measure: xuanwu syringomyelia scale measure: Incidence of complications sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fengzeng Jian status: RECRUITING city: Beijing state: Beijing City zip: 100032 country: China name: fengzeng jian, md role: CONTACT email: jianfengzeng@xwh.ccmu.edu.cn lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06268080 id: A+9317 briefTitle: Depth of Anesthesia on Postoperative Delirium and Cognitive After Surgery acronym: Balanced-2 overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2027-12-31 date: 2028-12-31 date: 2024-02-20 date: 2024-02-20 name: Auckland City Hospital class: OTHER_GOV briefSummary: The goal of this clinical trial (Balanced-2 study) is to compare light to deep general anesthesia using widely available brain monitors, to see if 'light' anesthesia could reduce rates of delirium, cognitive decline, and disability in older adults undergoing major surgery.
Delirium is the most common serious surgical complication, occurring in an estimated one in four older adults undergoing major surgery. Delirium causes significant distress to patients and family, and is associated with prolonged hospital stay, physical disability, progression to dementia-like illnesses, and discharge to long-term care. Between 10 - 30% of adults aged 70 years and above have surgery every year, and preserving brain health and wellbeing is an important priority during this time.
Older adults (aged ≥65 years, or Indigenous, Pasific patients aged ≥55 years) undergoing major surgery with general anesthesia (excluding heart and brain surgery) and able to provide consent will be able to participate. Participants will be randomized to two groups - a lighter general anesthesia group and a deeper general anesthesia group using processed electroencephalography (a brain monitor that provides information on depth of anesthesia using brain waves). The anesthesiologist will titrate anesthetic drugs according to the brain monitor. Participants will be followed up to determine if they experience delirium after surgery, and longer term impact of delirium such as cognitive and physical decline will also be measured.
If found to be effect, this simple, cheap, and widely available treatment could reduce disability, preserve brain health and wellbeing of many older adults undergoing surgery worldwide, and save millions in healthcare dollars. conditions: Delirium, Postoperative conditions: Anesthesia conditions: Surgery-Complications conditions: Cognition Disorder conditions: Delirium conditions: Cognitive Decline studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Multicentre, prospective, randomized, active control, parallel group, intention to treat, safety and efficacy study. primaryPurpose: PREVENTION masking: TRIPLE maskingDescription: Blinding of procedural anesthesiologist is not possible. Patients, surgeons, and all outcome assessors will be blinded. One unblinded research coordinator at each site will collect pEEG related data points. Other research coordinators will be blinded as to treatment allocation and will collect data relating to primary and secondary outcomes. Clinicians carrying out participant usual care will be able to unblind study allocation if necessary by viewing the patients anesthesia record via password protected, accessing clinician identity logged, Electronic Health Record (EHR). This record will be unavailable for access by other means. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 2766 type: ESTIMATED name: Depth of anesthesia titration using pEEG measure: Incidence of postoperative delirium (POD) measure: Incidence of severe delirium measure: Incidence of new mild and major postoperative neurocognitive disorders measure: Postoperative cognitive decline measure: Functional decline measure: All-cause mortality measure: Duration of delirium measure: Incidence of awareness measure: Adverse and serious adverse events sex: ALL minimumAge: 55 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06268067 id: Renal uptake at F18 FDG PET/CT briefTitle: Kidney Uptake at F-18 FDG PET/CT Studies and Renal Function Status overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-04-01 date: 2024-02-20 date: 2024-02-20 name: Assiut University class: OTHER briefSummary: Searching for a possible correlation between renal uptake at F-18-FDG PET/CT and renal functional parameters in both normal subjects and patients with CKD. conditions: Renal Uptake at F-18-FDG PET/CT studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 97 type: ESTIMATED name: PET/CT measure: significance of renal uptake at F18-FDG PET CT studies measure: Early detection of patients with CKD sex: ALL minimumAge: 19 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06268054 id: DEH113-III-0123 briefTitle: Efficacy and Safety of DEH113 in the Treatment of Menstrual Cramp Pain Associated With Primary Dysmenorrhea acronym: LIBERTÀ overallStatus: NOT_YET_RECRUITING date: 2025-02 date: 2027-02 date: 2027-09 date: 2024-02-20 date: 2024-02-22 name: EMS class: INDUSTRY briefSummary: The purpose of this study if to evaluate the efficacy and safety of DEH113 in the Treatment of Menstrual Cramp Pain Associated With Primary Dysmenorrhea. conditions: Primary Dysmenorrhea studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 78 type: ESTIMATED name: DEH113 name: Placebo Comparator measure: Sum of Total Pain Relief (TOTPAR) over 0-6 hours post-dose measure: Sum of Total Pain Relief (TOTPAR) over 0-4 and 0-8 hours post-dose measure: Sum of Pain Intensity Difference (SPID) over 4, 6 and 8 hours post-dose. measure: Use of rescue medication measure: Number of additional drug intake measure: Patients' Global Impression of Change (PGIC) measure: Incidence of Adverse Events Associated with DEH113 in the Treatment of Primary Dysmenorrhea sex: FEMALE minimumAge: 16 Years maximumAge: 35 Years stdAges: CHILD stdAges: ADULT hasResults: False