hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06390072 id: 23-X-71 briefTitle: Project Hypnos: The Impact of a Brief Hypnosis Intervention on Single-limb Dynamic Balance in People With Chronic Ankle Instability overallStatus: COMPLETED date: 2023-09-25 date: 2023-11-27 date: 2023-11-27 date: 2024-04-29 date: 2024-04-29 name: Ohio University class: OTHER briefSummary: This study will determine the relationship of one's self-reported awareness of their body and their ankle motor control for people with chronic ankle instability. This study will further identify the correlates between certain psychological characteristics (i.e., fear and anxiety) and autonomic nervous system arousal (i.e., heart rate variability). Furthermore, this study will elucidate the potential impact of a brief hypnosis practice on balance performance. conditions: Ankle Sprains conditions: Motor Coordination or Function; Developmental Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: This basic experimental pilot study involved a randomized cross-over design of two brief interventions with a 1:1 allocation ratio primaryPurpose: TREATMENT masking: NONE count: 24 type: ACTUAL name: Self-Hypnosis name: Ankle Education measure: Balance test 1 measure: Balance test 2 measure: Heart rate variability measure: Ankle disability measure 1 measure: Ankle disability measure 2 measure: Interoceptive awareness measure 1 measure: Interoceptive awareness measure 2 measure: Emotional Distress-Anxiety measure: Kinesiophobia measure: Pain self-efficacy sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ohio University city: Athens state: Ohio zip: 45701 country: United States lat: 39.32924 lon: -82.10126 hasResults: False
nctId: NCT06390059 id: EF-39 id: EF-39 type: OTHER domain: Sponsor id: 2022-003157-55 type: EUDRACT_NUMBER briefTitle: EF-39 PANOVA-4: Study of Tumor Treating Fields Concomitant With Atezolizumab, Gemcitabine and Nab-Paclitaxel as First-LineTreatment for Metastatic Pancreatic Ductal Adenocarcinoma overallStatus: RECRUITING date: 2023-08-28 date: 2026-08 date: 2026-08 date: 2024-04-29 date: 2024-04-29 name: NovoCure GmbH class: INDUSTRY briefSummary: The PANOVA-4 study is designed to evaluate the safety and efficacy of Tumor Treating Fields (TTFields) therapy together with atezolizumab, gemcitabine and nab-paclitaxel, for the treatment of metastatic pancreatic cancer. The study is intended for patients who have been diagnosed with metastatic pancreatic cancer and have not received prior systemic therapy. conditions: Metastatic Pancreatic Ductal Adenocarcinoma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Prospective, open-label, single arm, multi-center, historical control pilot study. primaryPurpose: TREATMENT masking: NONE count: 76 type: ESTIMATED name: Tumor Treating Fields name: Atezolizumab name: Gemcitabine name: nab-paclitaxel measure: Disease control rate (DCR) measure: Overall survival (OS) measure: Progression-free survival (PFS) measure: 1-Year survival rate measure: Objective response rate (ORR) measure: Progression free survival at 6 months (PFS6) measure: Duration of response (DOR) measure: Rate of of patients with treatment emergent adverse events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Hospital Vall d'Hebron status: RECRUITING city: Barcelona zip: 08035 country: Spain name: Teresa Macarulla Mercade role: CONTACT phone: 34 (93) 274 6085 email: tmacarulla@vhebron.net lat: 41.38879 lon: 2.15899 facility: University Hospital Foundation Jimenez Diaz status: RECRUITING city: Madrid zip: 28040 country: Spain name: Angela Lamarca Lete role: CONTACT phone: 34 951 504800 email: angela.lamarca@quironsalud.es name: 1 role: CONTACT lat: 40.4165 lon: -3.70256 facility: Clara Campal Comprehensive Cancer Center (CIOCC) status: RECRUITING city: Madrid zip: 28050 country: Spain name: Antonio Cubillo Gracian role: CONTACT phone: 34 91 756 7800 email: acubillo@hmhospitales.com lat: 40.4165 lon: -3.70256 facility: Regional University Hospital of Malaga status: RECRUITING city: Málaga zip: 29010 country: Spain name: Inmaculada Ales role: CONTACT phone: 34 951308129 email: inales@hotmail.com lat: 36.72016 lon: -4.42034 facility: University Clinic of Navarra - Pamplona status: RECRUITING city: Pamplona zip: 31008 country: Spain name: Mariano Ponz-Sarvise role: CONTACT phone: 34 948 255 400 email: mponz@unav.es lat: 42.81687 lon: -1.64323 hasResults: False
nctId: NCT06390046 id: 1072.6120.135.2023 briefTitle: Opioid-free Anesthesia, Optimization of Anesthesia After Bariatric Surgery overallStatus: RECRUITING date: 2024-03-14 date: 2025-12-31 date: 2025-12-31 date: 2024-04-29 date: 2024-04-29 name: Jagiellonian University class: OTHER briefSummary: Total intravenous general anesthesia and combined general anesthesia are recognized methods used during anesthesia. They allow you to effectively control pain and reduce the number of complications associated with taking large doses of opioid drugs. It should be emphasized that both methods of anesthesia are currently approved for use in routine anesthetic practice, and only the experience, knowledge and preferences of the anesthesiologist determine which technique will be used in a given patient. Both techniques are used in everyday anesthetic practice, but there is no conclusive scientific data confirming the superiority of either method in patients undergoing bariatric surgery, therefore currently only the individual experience, knowledge and preferences of the anesthesiologist determines which technique will be used in a given patient. conditions: Analgesics, Opioid conditions: Anesthesia; Adverse Effect studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study group will be male and female patients, ASA II or III, over 18 years of age and under 75 years of age. Each patient will undergo abdominal (bariatric) surgery. primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 200 type: ESTIMATED name: Intubation name: TIVA versus Inhalation measure: compare the effectiveness of analgesia measure: determine whether modern technologies such as videolaryngoscopy shorten intubation time. measure: incidence of postoperative nausea and vomiting sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Jagiellonian University status: RECRUITING city: Kraków state: Malopolskie zip: 31501 country: Poland name: Tomasz Skladzien, phd md role: CONTACT phone: 506602250 phoneExt: 48 email: t.skladzien@interia.pl lat: 50.06143 lon: 19.93658 hasResults: False
nctId: NCT06390033 id: ITS/133/21 briefTitle: Biomechanical Study of Different Prostheses for Unilateral Transtibial Amputees During Indoor and Outdoor Activities overallStatus: ENROLLING_BY_INVITATION date: 2023-06-30 date: 2024-04-30 date: 2024-06-30 date: 2024-04-29 date: 2024-04-29 name: The Hong Kong Polytechnic University class: OTHER briefSummary: The goal of this observational study is to evaluate and compare the performance of two prosthetic feet for unilateral transtibial amputees during both indoor and outdoor activities. The main research questions aim to answer are:
4. Participants will undergo a series of clinical tests, including: 1) Time to Go Up (measured in seconds), 2) Four Square Step Test (measured in seconds), 3) 10-Meter Walk Test (measured in seconds), 4) Eye Close Standing, 5) Tandem Test, and 6) Functional Reach Test. Each test will be conducted three times. The test items of 4) and 5) will be performed on a force plate (Bertect, Ohio, USA) with dimensions of 400 x 600 mm and a capturing frequency of 1,000 Hz.
8. Finally, participants will be asked to complete the Locomotion Capabilities Index questionnaire. conditions: Amputation conditions: Prosthesis User studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 6 type: ESTIMATED name: Prosthetic foot measure: Basic mobility function with two prostheses by Berg Balance Test measure: Basic mobility function with two prostheses by Time to Go Up measure: Basic mobility function with two prostheses by Four Square Step Test measure: Basic mobility function with two prostheses by 10-meter Walk Test measure: Stability index with two prostheses by Eye Close Standing measure: Stability index with two prostheses by Tandem Test measure: Functional Reach Test measure: Gait symmetry analysis of lower limb joint angle measure: Gait symmetry analysis of lower limb joint power measure: Gait symmetry analysis of lower limb joint moment measure: Walking feasibility with two prostheses measure: Jump feasibility with two prostheses measure: Subjective evaluation by Locomotion Capabilities Index questionnaire sex: ALL minimumAge: 36 Years maximumAge: 64 Years stdAges: ADULT facility: The Hong Kong Polytechnic University city: Kowloon zip: 999077 country: Hong Kong lat: 22.31667 lon: 114.18333 hasResults: False
nctId: NCT06390020 id: NL84880.091.23 briefTitle: Mindfulness-Based Stress Reduction (MBSR) for People High on the Personality Trait Sensory Processing Sensitivity: A Mixed Methods Study acronym: MindSens overallStatus: RECRUITING date: 2024-01-15 date: 2024-12 date: 2024-12 date: 2024-04-29 date: 2024-04-29 name: Radboud University Medical Center class: OTHER briefSummary: This study investigates the efficacy of MBSR training in alleviating stress-related symptoms among individuals with high sensory processing sensitivity. Participants will be randomly allocated to either the MBSR group or the control group.
The primary hypothesis is that participants in the MBSR group, relative to control group, will have lower depression-anxiety-stress scores post-intervention, after controlling for baseline scores. The secondary hypothesis is that in the MBSR group, relative to control group, other mental health, physical health and well-being outcomes, as well as potential mindfulness mechanisms will also improve, after controlling for baseline scores. conditions: Sensory Processing Sensitivity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 52 type: ESTIMATED name: MBSR measure: Change from Baseline to Post-intervention in self-reported depression, anxiety, and stress measure: Change from Baseline to Post-intervention in self-reported well-being measure: Change from Baseline to Post-intervention in self-reported burnout symptoms measure: Change from Baseline to Post-intervention in self-reported physical symptoms measure: Change from Baseline to Post-intervention in self-reported overstimulation measure: Change from Baseline to Post-intervention in self-reported mindfulness measure: Change from Baseline to Post-intervention in self-reported attention regulation measure: Change from Baseline to Post-intervention in self-reported strategies for cognitive emotion regulation measure: Change from Baseline to Post-intervention in self-reported body awareness measure: Change from Baseline to Post-intervention in self-reported self-compassion measure: Change from Baseline to Post-intervention in self-reported sensory processing sensitivity measure: Perceived facilitators, barriers, effects, and mechanisms of participating in the MBSR training sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Radboudumc Center for Mindfulness status: RECRUITING city: Nijmegen state: Gelderland zip: 6525 GC country: Netherlands name: Anne Speckens, prof. dr. role: CONTACT phone: (024) 36 68 456 email: mindfulness@radboudumc.nl lat: 51.8425 lon: 5.85278 hasResults: False
nctId: NCT06390007 id: 24916 briefTitle: The Efficacy of Acupuncture in the Management of Postoperative Pain in the Pediatric Intensive Care Unit at Cipto Mangunkusumo Hospital overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-11 date: 2024-12 date: 2024-04-29 date: 2024-04-29 name: Indonesia University class: OTHER briefSummary: Pain is an unpleasant sensory and emotional experience resulting from tissue damage. Pain management is typically conducted according to the World Health Organization (WHO) pain management ladder. Analgesics administered to pediatric patients vary in dosage and type, but these analgesics often have significant side effects. The acupuncture technique using press needles is a non-pharmacological pain therapy modality that has been studied for its ability to reduce the use of analgesic drugs, thereby potentially decreasing side effects associated with analgesic use.
The study was conducted using a randomized controlled trial (RCT) design involving 70 pediatric postoperative patients aged 1-18 years who were admitted to the Pediatric Intensive Care Unit at Cipto Mangunkusumo Hospital. Subjects were divided into two groups: a control group and an experimental group. The control group received standard analgesic therapy and sham press needle application (a patch resembling a press needle without a needle), while the experimental group received standard analgesic therapy and press needle application at acupuncture points after the patient had been in the Pediatric Intensive Care Unit for 24 hours. Pain scale monitoring was conducted at 1, 6, 24, 48, and 72 hours using the Face, Legs, Activity, Cry, and Consolability (FLACC) scale for children aged 1-8 years, and the Numeric Rating Scale (NRS) for children over 8 years old.
This study hypothesizes that the acupuncture technique using press needles can reduce the pain scale in pediatric postoperative patients, leading to a decrease in the use of analgesics and a reduction in side effects associated with analgesic use. conditions: Pain, Postoperative conditions: Pediatric Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE whoMasked: PARTICIPANT count: 70 type: ESTIMATED name: Sham press needle name: Press needle acupuncture measure: Face, Legs, Activity, Cry, and Consolability (FLACC) pain scale measure: Numeric Rating Scale (NRS) pain scale sex: ALL minimumAge: 1 Year maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: RSUPN Dr. Cipto Mangunkusumo city: Jakarta Pusat state: DKI Jakarta zip: 10430 country: Indonesia name: Irene Yuniar role: CONTACT phone: +6281380327808 email: irene.tambunan@yahoo.co.id lat: -6.1818 lon: 106.8223 hasResults: False
nctId: NCT06389994 id: 23-021041 briefTitle: Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral Immunotherapy overallStatus: RECRUITING date: 2024-04-01 date: 2026-04-02 date: 2026-10-01 date: 2024-04-29 date: 2024-04-29 name: Children's Hospital of Philadelphia class: OTHER briefSummary: Patients with IgE mediated food Allergy have elevated risk of eosinophilic esophagitis, and new therapies like oral immunotherapy (OIT) carry additional risk of Eosinophilic Esophagitis (EoE). The goal of this study is to investigate the Esophageal String Test (EST) as a screening tool for Eosinophilic Esophagitis (EoE) during OIT therapy. Investigators will compare the efficacy of the Esophageal String Test to symptom assessment using a validated patient reported symptom questionnaire, the Pediatric Eosinophilic Esophagitis Symptom Score (PEESS) v2.0. Investigators will utilize these tools to screen patients at their baseline visit prior to the start of OIT, then at the 3- and 6-month OIT follow-up visits. conditions: Eosinophilic Esophagitis (EoE) studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 75 type: ESTIMATED name: Esophageal String Test measure: Esophageal String Test measure: Prevalence of Eosinophilic Esophagitis measure: Eosinophilic Esophagitis Symptoms sex: ALL minimumAge: 7 Years maximumAge: 17 Years stdAges: CHILD facility: The Children's Hospital of Philadelphia status: RECRUITING city: Philadelphia state: Pennsylvania zip: 19104 country: United States name: Sharon A Carbonara, MS, BSN, RN role: CONTACT phone: 267-426-8603 email: carbonara@chop.edu lat: 39.95233 lon: -75.16379 hasResults: False
nctId: NCT06389981 id: 1692052 briefTitle: Co-Design and Pilot Testing of Peer-led Community Outreach to Improve Equity, Veteran-Centeredness and Uptake of Lung Cancer Screening acronym: VPC overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-02-28 date: 2025-06-30 date: 2024-04-29 date: 2024-04-29 name: VA Boston Healthcare System class: FED briefSummary: Co-design will be implemented to develop an innovative, Veteran-centered intervention (Vet Peer Connects program) that meets the needs of Black Veterans.
Next, a feasibility pilot test of the Vet Peer Connects program will be conducted. The Peer will lead up to 4 group lung cancer screening orientations in community partner sites to reach around 40 lung cancer screening eligible Black Veterans. The Peer will provide one-to-one tailored support to up to 15 Veterans (coaching, goal-setting, navigation to access Veterans Affairs lung cancer screening). Then, the study team will evaluate program delivery through ethnographic observation and field notes, Peer activity logs, and weekly check-ins between the study team and Peer. Investigators will interview Veteran participants, community partners, and lung cancer screening clinical staff to explore feasibility and acceptability of the Vet Peer Connects program and solicit suggestions for improvement. Preliminary data on the outcomes of the Vet Peer Connects program will be collected by study team through administering surveys to assess change in Social Cognitive Theory constructs, and extracting lung cancer screening uptake and tobacco treatment 3 months post enrollment from VA's Corporate Data Warehouse. This work will inform a subsequent multi-site stepped-wedge trial to assess effectiveness, implementation, and cost of the Vet Peer Connects program in VA lung cancer screening sites and neighboring branches of the National Association for Black Veterans conditions: Lung Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 40 type: ESTIMATED name: Veterans peer connect Program measure: Lung Cancer Screening Uptake measure: Tobacco cessation Treatment measure: Stigma Related to Smoking measure: Perceived support from peer measure: Lung Cancer Screening Knowledge measure: Lung Cancer Screening Fatalism measure: Trust in VA measure: Lung Cancer Self-efficacy measure: General Cancer Self-efficacy measure: Intention to engage in shared decision making measure: Motivation to quit smoking measure: Intention to undergo lung cancer screening sex: ALL minimumAge: 50 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06389968 id: 2023-491-S-KH briefTitle: Light Stimulation to Improve Visual Function After Optic Neuritis in Persons With Multiple Sclerosis acronym: ONSTIM overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2025-12-31 date: 2025-12-31 date: 2024-04-29 date: 2024-04-29 name: Technical University of Munich class: OTHER briefSummary: The aim of this monocentric randomized controlled intervention study is to improve visual function in persons with multiple sclerosis (pwMS) following optic neuritis (neuritis nervi optici, NNO) by means of a light stimulation.
In the treatment arm, two 80-second light stimulations are to be administered daily for 12 days in 25 pwMS following recent NNO (1-3 months). For the standardized application of light stimulation in the sense of standardized training, the light stimulation is to be carried out by watching a generated flicker video on a mobile phone. In a sham-intervened control group (n=25), the spontaneous course after NNO will be recorded in parallel. Intensive neuronal stimulation of the visual pathway will be used to stimulate regenerative processes, which will be recorded by means of changes in high-contrast visual acuity (primary endpoint). Secondary endpoints are changes in a colored-contrast test, in 2.5% low contrast visual acuity (LCVA), the P100 conduction latency of visual evoked potentials, and retinal layer thicknesses and vessel densities measured in optical coherence tomography (OCT) and OCT angiography (OCTA). These physiological parameters should help to understand the underlying processes of a potentially altered visual performance. conditions: Multiple Sclerosis, Relapsing-Remitting conditions: Optic Neuritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: sham-controlled primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 50 type: ESTIMATED name: Light stimulation name: Sham light stimulation measure: High contrast visual sensitivity measure: Low contrast visual sensitivity measure: VEP measure: OCT measure: OCT Angiography measure: Color contrast sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
nctId: NCT06389955 id: TP-3654-103 briefTitle: Assessment of Relative Bioavailability and Effect of Food on Capsule and Tablet Formulations of TP-3654 overallStatus: COMPLETED date: 2023-05-22 date: 2023-08-01 date: 2023-08-24 date: 2024-04-29 date: 2024-04-29 name: Sumitomo Pharma America, Inc. class: INDUSTRY briefSummary: This study comprised of 2 parts, Part A and Part B. Part B will only be conducted if the relative bioavailability of the tablet formulation was at least 70% of the capsule formulation. conditions: Effect of Drug studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: NONE count: 12 type: ACTUAL name: TP 3654 measure: Part A - The maximum concentration (Cmax) of TP-3654 in a capsule formulation measure: Part A - The area under the curve (AUC) of TP-3654 in a capsule formulation measure: Part A - Ratio of Peak Plasma Concentration (Cmax) of TP-3654 tablet versus TP-3654 capsule under fasted conditions measure: Part B - The maximum concentration (Cmax) of TP-3654 in a tablet formulation measure: Number of participants with Treatment Emergent Adverse Events (TEAE) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Frontage Investigative Site city: Secaucus state: New Jersey zip: 07094 country: United States lat: 40.78955 lon: -74.05653 hasResults: False
nctId: NCT06389942 id: 9MW3011-2022-CP101 briefTitle: Single Ascending Dose Study of 9MW3011 in Chinese Healthy Subject overallStatus: ACTIVE_NOT_RECRUITING date: 2023-03-10 date: 2024-04 date: 2024-04 date: 2024-04-29 date: 2024-04-29 name: Mabwell (Shanghai) Bioscience Co., Ltd. class: INDUSTRY briefSummary: The objectives of the study are to evaluate the safety , tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of single ascending intravenous (IV) doses of 9MW3011 in Chinese healthy volunteers. conditions: Healthy studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 48 type: ACTUAL name: 9MW3011 name: 9MW3011 placebo measure: Adverse Event(including serious adverse event) measure: Number of subjects with abnormal vital signs measure: Number of subjects with abnormal clinically significant results from physical examination measure: Number of subjects with abnormal clinically significant 12-lead electrocardiogram (ECG) parameters measure: Number of subjects with abnormal clinically significant clinical laboratory results measure: Cmax measure: AUC0-t measure: AUC0-∞ measure: Tmax measure: λz measure: t1/2z measure: Vz measure: CL measure: MRT measure: Pharmacodynamic(PD)parameters-hepcidin measure: PD parameters-serum iron measure: PD parameters-TSAT measure: Anti-drug antibodies(ADA) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: PKUcare Luzhong Hospital city: Zibo state: Shandong country: China lat: 36.79056 lon: 118.06333 hasResults: False