hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06381141 id: CLN-619-002 briefTitle: A Study of CLN-619 (Anti-MICA/MICB Antibody) in Patients With Relapsed and Refractory Multiple Myeloma overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2026-09 date: 2027-03 date: 2024-04-24 date: 2024-04-24 name: Cullinan Therapeutics Inc. class: INDUSTRY briefSummary: A Phase 1b, Multicenter, Open-Label, Study to Investigate the Safety and Efficacy of CLN-619 (anti-MICA/MICB Antibody) in Patients with Relapsed and Refractory Multiple Myeloma conditions: Multiple Myeloma studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: CLN-619 measure: Proportion of participants reporting Adverse Events (AEs) and Serious Adverse Events (SAEs) measure: Changes in Eastern Cooperative Oncology Group (ECOG) performance measure: Incidence of Dose-Limiting toxicity (DLTs) measure: Best Overall Response (BOR) per patient measure: Overall Response Rate (ORR) measure: Duration of Response (DoR) measure: Clinical Benefit Rate (CBR) measure: Progression Free Survival (PFS) measure: Overall Survival (OS) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06381128 id: CAA by CT in children with CHD briefTitle: Coronary Arteries Anomalies by CT in Children With CHD overallStatus: NOT_YET_RECRUITING date: 2025-01-01 date: 2026-01-01 date: 2029-12-31 date: 2024-04-24 date: 2024-04-24 name: Assiut University class: OTHER briefSummary: Delineate coronary artery anatomy and detection of coronary anomalies in children with complex cardiac anomalies by cardiac CT-angiography before total surgical correction. conditions: Cardiac Congenital Defects studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 100 type: ESTIMATED name: Cardiac CT measure: Detection of coronary arteries anomalies by computed tomography angiography in children with congenital heart disease sex: ALL minimumAge: 1 Day maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06381115 id: 23-006685 briefTitle: App-Based Optimization of Long-Term CPAP Adherence and Quality of Life overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-11 date: 2024-11 date: 2024-04-24 date: 2024-04-24 name: Mayo Clinic class: OTHER name: Arizona State University (ASU) briefSummary: The purpose of this study is to optimize the time of CPAP usage to at least 6 hours a night for 6 nights per week for people who have OSA with the help of a smartphone application called SmartWell24. This application aims to target CPAP adherence. conditions: Obstructive Sleep Apnea studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: SleepWell24 Application measure: CPAP Adoption measure: Change in Quality of Life measure: Change in sleep time measure: Change in physical activity measure: Change in sedentary time sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mayo Clinic in Arizona city: Scottsdale state: Arizona zip: 85259 country: United States lat: 33.50921 lon: -111.89903 facility: Mayo Clinic in Rochester city: Rochester state: Minnesota zip: 55905 country: United States lat: 44.02163 lon: -92.4699 hasResults: False
nctId: NCT06381102 id: 20240134 briefTitle: Transcutaneous Vagus Nerve Stimulation (taVNS) Dosage Study 1 overallStatus: RECRUITING date: 2024-04-13 date: 2024-10-01 date: 2024-10-01 date: 2024-04-24 date: 2024-04-24 name: University of Miami class: OTHER briefSummary: The purpose of this research study is to investigate the effects of different forms of a gentle form of electrical stimulation applied to the ear, known as transcutaneous auricular vagus nerve stimulation (taVNS). The research team is interested in how the different forms affect comfort and tolerability, as well as how well it works. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: transcutaneous auricular vagus nerve stimulation 30/30 name: transcutaneous auricular vagus nerve stimulation 10/10 measure: Tolerability measured by tolerability questionnaire measure: Tolerability measured by self-report measure: Change in heart rate variability (HRV) sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Miami status: RECRUITING city: Miami state: Florida zip: 33136 country: United States name: Gabriel Gonzalez, DPT role: CONTACT phone: 305-243-8117 email: gxg651@miami.edu name: Marlon Wong, PT, PhD role: PRINCIPAL_INVESTIGATOR name: Gabriel Gonzalez, DPT role: SUB_INVESTIGATOR name: Jessica Bolanos, DPT role: SUB_INVESTIGATOR lat: 25.77427 lon: -80.19366 hasResults: False
nctId: NCT06381089 id: VNS004 briefTitle: Effect Of Robotic Rehabilitation And Vagus Nerve Stimulation In Ischemia Stroke Patients acronym: ERRVNS overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2024-07-10 date: 2024-08-10 date: 2024-04-24 date: 2024-04-24 name: SEFA HAKTAN HATIK class: OTHER briefSummary: This study was conducted in patients with ischemic stroke; This study was conducted to examine the effect of robotic rehabilitation and transcutaneous auricular vagal nerve stimulation applied in addition to robotic rehabilitation on the patient's functional level and autonomic nervous system.
40 people over the age of 18 participated in the study. They were randomly divided into two groups: robotic rehabilitation and transcutaneous auricular vagal nerve stimulation applied in addition to robotic rehabilitation. While the robotic rehabilitation group received Lokomat and neurological rehabilitation, the other group received stimulation with the Vagustim device, which is applied non-invasively through the ear, in addition to Lokomat and neurological rehabilitation. Spasticity, autonomic nervous system, walking speed, motor function, quality of life, muscle activity and pain were evaluated in both groups before starting treatment and six weeks after treatment. In the study, significance was evaluated at p\<0.05 level. conditions: Ischemic Stroke conditions: Vagus Nerve Stimulation conditions: Robotic Rehabilitation conditions: Autonomic Nervous System studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 40 type: ESTIMATED name: Robotic Rehabilitation name: Transcutaneous Auricular Vagal Nerve Stimulation measure: Numerical Pain Rating Scale measure: Stroke Specific Quality of Life Scale measure: 10 Meter Walk Test measure: Fugl-Meyer Assessment Lower Extremity measure: Modified Ashworth Scale measure: Electromyography measure: Autonomic Nervous System sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06381076 id: IRB202400087 briefTitle: Examining the Impact of High-protein Oral Supplement With Liposomal Curcumin on Inflammation Markers and Oxidative Stress in Adults Undergoing Hemodialysis. overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-12 date: 2025-12 date: 2024-04-24 date: 2024-04-26 name: University of Florida class: OTHER briefSummary: A 12-week double-blind randomized control trial will be conducted among adults on hemodialysis (n=15) to determine the impact of liposomal curcumin in a high-protein product on inflammation markers and oxidative stress. Participants will be randomized via a computer-generator into either the control or intervention group. Participants in each group will be given a total of 38 g of a high protein product with or without 7 mls of liposomal curcumin for a total of 8 weeks. At baseline, weeks 8 and 12, participants will have blood sampled and complete a 3-day 24-hour recalls (2 non-dialysis days and 1 dialysis day) and a quality of life survey. conditions: Chronic Kidney Disease 5D studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized comparator-controlled trial primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Participants will receive a 3-digit coded product that either contains 7 mls of liposomal curcumin or food colorant. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 30 type: ESTIMATED name: Liposomal curcumin name: Food colorant measure: high-sensitivity C-reactive protein measure: Advanced glycation end products measure: fatty acid byproduct - 4-hydroxynon-enal measure: fatty acid byproduct - malondialdehyde measure: fatty acid byproduct - 8-F2 isoprostanes measure: Klotho sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06381063 id: PI2023_843_0152 briefTitle: Non-steroidal Anti-inflammatory in Cardiac Surgery acronym: KETOPAIN overallStatus: RECRUITING date: 2024-03-27 date: 2027-03 date: 2027-07 date: 2024-04-24 date: 2024-04-24 name: Centre Hospitalier Universitaire, Amiens class: OTHER name: University Hospital, Rouen name: University Hospital, Lille briefSummary: Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication. conditions: Acute Postoperative Pain conditions: Non-steroidal Anti-inflammatory Drugs conditions: Cardiac Surgery conditions: Pain Intensity conditions: Multimodal Pain Management studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 238 type: ESTIMATED name: pain management name: ketoprofen name: PLacebo measure: reduction in pain intensity during chest physiotherapy at 24 hours from the end of surgery measure: NSAIDs reduce postoperative at rest at 24 hours from the end of surgery measure: Change in pain trajectory during the first 7 days after cardiac surgery measure: Change in cumulative opioid within 48 hours after surgery measure: Change in pulmonary postoperative complications within 7 days after surgery sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU Amiens Picardie status: RECRUITING city: Amiens country: France name: Osama ABOU ARAB role: CONTACT email: abouarab.osama@chu-amiens.fr name: Emmanuel BESNIER, MD role: PRINCIPAL_INVESTIGATOR name: Mouhamed MOUSSA, MD role: PRINCIPAL_INVESTIGATOR lat: 49.9 lon: 2.3 hasResults: False
nctId: NCT06381050 id: SHR-7631-101 briefTitle: The Clinical Study of SHR-7631 for Injection in Patients With Advanced Solid Tumors overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2027-04 date: 2024-04-24 date: 2024-04-24 name: Suzhou Suncadia Biopharmaceuticals Co., Ltd. class: INDUSTRY briefSummary: This study is an open-label, phase I clinical trial of SHR-7631 in patients with advanced solid tumors. The whole study is divided into three stages: dose escalation, dose expansion and efficacy expansion. conditions: Advanced Solid Tumors studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 150 type: ESTIMATED name: SHR-7631 measure: Maximum tolerated dose (MTD) or maximum administered dose (MAD) measure: Incidence and severity of adverse events (AEs)/serious adverse events (SAEs) (CTCAE v5.0) measure: PK parameter: Tmax measure: PK parameter: Cmax measure: PK parameter: AUC0-t measure: PK parameter: AUC0-∞ measure: PK parameter: t1/2 measure: PK parameter: MRT (mean residence time) sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06381037 id: PID2021-127986OB-I00 briefTitle: Quality of Life and Psychological Strengths of Older People acronym: QUALIFRAG overallStatus: RECRUITING date: 2023-09-01 date: 2026-01-31 date: 2026-08-31 date: 2024-04-24 date: 2024-04-24 name: CEU San Pablo University class: OTHER briefSummary: As the 2019 coronavirus pandemic (COVID-19) overspreads around the world, and scientists try to elucidate about the complexity of the virus, there is clear potential for it to become a long-lasting global illness. In this picture, Spain has emerged as one of the most affected countries with a high prevalence rate. The possibility of illness or even death, the uncertainty of the future, or the required physical estrangement, make this epidemic a highly stressful situation with potential long-term consequences on the physical and psychological wellbeing of the population, just isolation raises the probability of health problems like depression and anxiety. However, the same event does not affect everybody equally. The ultimate effect of a stressor will depend on its appraisal as a threat and the resources the person counts on to copy and several biopsychosocial variables could play an important role, as risk or protective factors. conditions: Quality of Life conditions: Skills, Coping studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Quantitative, observational and longitudinal study with three measurements (pre-intervention, post-intervention and monitoring). primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 110 type: ESTIMATED name: "How to improve your strengths and quality of life". measure: Quality of life measure: Psychological wellbeing measure: Loneliness measure: Anxiety and depression Anxiety and depression measure: Gratitude measure: Experiential acceptance measure: Resilience measure: Family functioning sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: San Pablo CEU University (Campus Montepríncipe) status: RECRUITING city: Alcorcón state: Madrid zip: 28925 country: Spain name: Leyre Galarraga Cristóbal role: CONTACT phone: 913724700 phoneExt: 14607 email: leyre.galarragacristobal@ceu.es name: Gema Pérez Rojo role: CONTACT phone: 913724700 phoneExt: 14999 email: gema.perezrojo@ceu.es lat: 40.34582 lon: -3.82487 typeAbbrev: SAP hasProtocol: False hasSap: True hasIcf: False label: Statistical Analysis Plan date: 2023-12-01 uploadDate: 2023-12-11T03:43 filename: SAP_000.pdf size: 70923 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-12-01 uploadDate: 2023-12-11T03:42 filename: ICF_001.pdf size: 71559 hasResults: False
nctId: NCT06381024 id: 2022 A02702-41 briefTitle: A Study of Telemonitoring in Cancer Patients acronym: MINERVA overallStatus: RECRUITING date: 2023-04-04 date: 2024-12-30 date: 2024-12-30 date: 2024-04-24 date: 2024-04-24 name: Centre Hospitalier de Bligny class: OTHER name: Exystat name: Cureety name: Pharmaspecific name: ProPens briefSummary: The goal of this prospective, randomized, unblinded, single-centre, interventional study is to assess the effectiveness of standard of care with Cureety, compared to standard of care alone, to reduce the number of all telephone calls during the first 4 months of oral or intravenous cancer treatment for patients older than 18 years of age, initiating oral or intravenous cancer treatment at the Centre Hospitalier de Bligny.
• Oral versus intravenous cancer treatment. The number of patients initiating oral treatment at randomization will be restricted to 20 patients. primaryPurpose: TREATMENT masking: NONE count: 82 type: ESTIMATED name: remote patient monitoring measure: Number of all telephone calls during the first 4 months of oral or intravenous cancer treatment measure: Duration of all telephone calls during the first 4 months of oral or intravenous cancer treatment measure: Numbers of telephone calls during the first 4 months of cancer treatment in subgroups measure: Hospital-free survival rate measure: Quality of life at 2 and 4 months after initiation of cancer treatment. measure: Patient satisfaction with the healthcare provided measure: CH Bligny staff satisfaction with the healthcare provided sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre Hospitalier de Bligny status: RECRUITING city: Briis-sous-Forges zip: 91640 country: France name: Ingrid Alexandre, MD role: CONTACT phone: +33169263138 email: i.alexandre@chbligny.fr name: Ingrid Alexandre, MD role: PRINCIPAL_INVESTIGATOR lat: 48.62399 lon: 2.12112 hasResults: False
nctId: NCT06381011 id: BEUFTR-4 briefTitle: Local Vibration in Cervical Radiculopathy overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-06-01 date: 2024-09-01 date: 2024-04-24 date: 2024-04-24 name: Bitlis Eren University class: OTHER briefSummary: The aim of this study is to evaluate the effect of local vibration application on the upper extremity pain, paresthesia, neck pain, and limitations in cervical joint range of motion experienced by patients with cervical radiculopathy. conditions: Cervical Radiculopathy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: The evaluator and the researcher administering the local vibration application will be different. Patients will be blinded to their group assignment. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 34 type: ESTIMATED name: Local Vibration measure: Neck Pain measure: Upper Limb Pain measure: Paresthesia measure: Cervical Range of Motion measure: The Change in the Pressure Pain Threshold of the Upper Trapezius measure: The Change in the Viscoelastic Properties of the Upper Trapezius sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Bitlis Eren University city: Bitlis state: Merkez zip: 13000 country: Turkey name: Ömer Dursun, Asst. Prof. role: CONTACT phone: 5426088687 phoneExt: +90 email: fztomrdrsn@gmail.com name: Erhan Dincer, M.Sc. role: CONTACT phone: 5442543857 phoneExt: +90 email: fzterhan@hotmail.com lat: 38.40115 lon: 42.10784 hasResults: False
nctId: NCT06380998 id: EPCPHCFAPAEWPSPSWAG briefTitle: Effects of Petroleum Compounds on Psychological Health and Cognitive Functions overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2025-10-01 date: 2027-10-01 date: 2024-04-24 date: 2024-04-24 name: Assiut University class: OTHER briefSummary: Over the last decade, awareness of the effects of hydrocarbon fuels on neurodegenerative disorders has increased significantly, as they are ubiquitous environmentally toxic chemicals that affect the central nervous system and result in irreversible neuronal damage, as many hydrocarbons can cross the blood-brain barrier through multiple pathways and cause direct toxicity. conditions: Cognitive Deterioration studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 196 type: ESTIMATED name: whey protien measure: Effects of petroleum compounds on psychological health and cognitive functions of petrol station workers in Assiut measure: To explore the relation between the level of petroleum hydrocarbon metabolites and the severity of psychological heath and cognitive functions disturbance of petrol station workers measure: To explore the role of supplements with whey protein in ameliorating these effects measure: To assess the relationship between the psychological effects, cognitive functions, and nutritional status of petroleum station workers sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Faculty of medicine city: Assiut state: Assiut University zip: 71515 country: Egypt lat: 27.18096 lon: 31.18368 hasResults: False
nctId: NCT06380972 id: HDM6009A-301 briefTitle: A Prospective, Randomized, No-treatment Controlled, Evaluator-blinded Clinical Trial to Evaluate the Efficacy and Safety of Polycaprolactone Microspherical Injectable to Improve Forehead Contour overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-09 date: 2025-10 date: 2024-04-24 date: 2024-04-24 name: AQTIS Medical B.V. class: OTHER briefSummary: A Prospective, Multicenter, Randomized, No-treatment-controlled, Evaluator-blinded, Superiority Clinical Trial to Evaluate the Efficacy and Safety of Polycaprolactone Based Facial Injectable to Improve Forehead Contour conditions: Forehead Contouring studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: the method of endpoint blind evaluation is adopted, that is, it's blinded for the evaluator. whoMasked: OUTCOMES_ASSESSOR count: 189 type: ESTIMATED name: Polycaprolactone (PCL) Based Facial Injectable measure: The response rate for improving the forehead contour is assessed by the blinded investigator using the Asian Sloping Forehead Scale (ASFS) measure: The response rate of forehead contour improvement assessed by blinded investigator using Asian Sloping Forehead Scale (ASFS) measure: The response rate of forehead contour improvement assessed by injection investigator using Asian Sloping Forehead Scale (ASFS) measure: The global aesthetic improvement rate assessed by the injection investigator based on the Global Aesthetic Improvement Scale (GAIS) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Guangdong Second Provincial General Hospital city: Guangzhou state: Guangdong zip: 510317 country: China name: Shengkang Luo role: CONTACT phone: 02089168071 email: luoshengkang63@hotmail.com name: WEIJIN HONG role: CONTACT phone: 02089168071 name: shengkang luo role: PRINCIPAL_INVESTIGATOR name: weijin hong role: SUB_INVESTIGATOR lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06380959 id: 223K879 briefTitle: Art-based Activities in Stroke Patients overallStatus: COMPLETED date: 2023-10-02 date: 2023-12-31 date: 2024-02-29 date: 2024-04-24 date: 2024-04-29 name: Ege University class: OTHER briefSummary: Introduction and Aim: Life after stroke begins a difficult period in which functional capacity is very limited. Disability persists for a long time, and various problems such as hemiparesis, hemiplegia, dysarthria, dysphagia, urinary and bowel incontinence, which are frequently encountered after stroke, can affect the quality of life in the long term. As non-pharmacological approaches, especially non-invasive methods, have gained attention, creative arts-based therapies have often been recommended for stroke survivors because they have an arts-based approach without side effects. It is thought that the study conducted will contribute to the literature as there are not many studies in the literature. The aim of this study is to examine the effects of art-based activities on stroke patients' hope and self-efficacy levels. Its sub-purpose is to reveal the feelings and thoughts that arise with art objects obtained from art-based activities applied to stroke patients.
Materials and Methods: The study was conducted as a randomised controlled design. After the groups were determined, art-based activities module was applied to the intervention group for one week, while no additional intervention was made to the control group. Research data were collected using "Individual Introduction Form", "Herth Hope Index", "Generalized Self-Efficacy Scale. Data were analyzed with Statistical Package for the Social Sciences 25.0 package program. Written permission was obtained from the relevant ethics committee, hospital and participants to conduct the study. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomised Controlled primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 72 type: ACTUAL name: Art Based Activity measure: Herth Hope Index measure: Generalized Self-Efficacy Scale measure: Individual Introduction Form measure: Art Object Concretization Form sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ege University city: Bornova state: İzmir zip: 35100 country: Turkey lat: 38.47921 lon: 27.2399 hasResults: False