hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06365580 id: Kylo-0603-I-C01 briefTitle: Dose Escalation Study of Kylo-0603 in Healthy Subjects overallStatus: RECRUITING date: 2023-05-23 date: 2024-06-30 date: 2024-06-30 date: 2024-04-15 date: 2024-04-16 name: Kylonova (Xiamen) Biopharma co., LTD. class: INDUSTRY briefSummary: This clinical trial is the first-in-human study of Kylo-0603. The purpose of this randomized, double-blind, placebo-controlled phase 1 study is to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and effect of food of Kylo-0603 in healthy Chinese adult subjects. conditions: Nonalcoholic Steatohepatitis studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 124 type: ESTIMATED name: Kylo-0603 capsule name: Placebo measure: incidence of adverse events measure: Pharmacokinetics (PK) parameter of maximum observed concentration (Cmax) measure: PK parameter of time of maximum observed concentration (Tmax) measure: PK parameter of area under the concentration time curve (AUC) sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: The first affiliated hospital, Zhejiang University School of Medicine status: RECRUITING city: Hangzhou state: Zhejiang zip: 310000 country: China lat: 30.29365 lon: 120.16142 hasResults: False
nctId: NCT06365567 id: CE209/2023 briefTitle: Dietary Fructose: a Metabolic Switch in Pediatric Obesity-related Disease. acronym: EO2022 overallStatus: RECRUITING date: 2024-03-04 date: 2025-03-05 date: 2026-03-02 date: 2024-04-15 date: 2024-04-15 name: Azienda Ospedaliero Universitaria Maggiore della Carita class: OTHER name: Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari briefSummary: The increase in childhood obesity is a multifactorial phenomenon influenced by dietary patterns, commercial factors, and social determinants; it has long-term consequences for both individual health and society as a whole. Despite recommendations for maintaining good health throughout life and promoting the Mediterranean Diet, due to the increased availability of ultra-processed and more appealing foods, children and adolescents are shifting towards a "Western" diet. One in four children consumes sugary and carbonated drinks every day, which contributes to a high intake of fructose in the diet, while fruits and vegetables are consumed less, and legumes are included in the diet of only 38% of children less than once a week.
Fructose is a monosaccharide naturally found in fruits, vegetables, and honey; due to its high sweetness and taste-enhancing properties, fructose is widely used in the food industry. High-fructose corn syrup, in particular, is one of the most widely used ingredients in the production of soft drinks, jams, breakfast cereals, and bakery products. Non-alcoholic fatty liver disease (NAFLD), now also called metabolic dysfunction-associated fatty liver disease (MAFLD), is considered the hepatic manifestation of metabolic syndrome and currently represents the most common chronic liver disease in pediatric age in Western countries. Recent studies suggest that fructose consumption is implicated in the development of NAFLD both directly by providing metabolites that can be used for triglyceride and free fatty acid synthesis, and indirectly through increased uric acid production. High-fructose foods also appear to be a risk factor for bone loss. Numerous studies conducted over the past 25 years, during which fructose consumption has exponentially increased, have shown that this sweetener tends to increase the incidence of fractures and osteoarthritis and decrease bone mineral density (BMD) and new bone tissue deposition.
The objective of this study is to understand the effect of fructose on the molecular events that contribute to the evolution of the pediatric age, and its effective relationship with the onset of liver and osteoarticular complications in this population. Understanding the mechanisms of fructose regulation and its effects on the body could be an important target to address the clinical and social problems arising from its spread in children. conditions: Pediatric Obesity studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 100 type: ESTIMATED measure: assessment of fructose intake with questionnaires measure: correlation of fructose consumption with hepatic complications, detected trough echo-abdomen and blood analysis measure: Correlation of fructose consumption with bone metabolism, detected through QUS measure: Characterization of the concentration of intestinal microorganisms measure: Evaluate sociodemographic and cultural determinants with questionnaires ( questions with multiple answers) sex: ALL minimumAge: 3 Years maximumAge: 16 Years stdAges: CHILD facility: SCDU Pediatria, AOU Ospedale Maggiore della Carità status: RECRUITING city: Novara zip: 28100 country: Italy name: Flavia Prodam, MD PHD role: CONTACT lat: 45.44694 lon: 8.62118 typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2023-12-21 uploadDate: 2024-04-11T05:17 filename: Prot_SAP_000.pdf size: 972421 hasResults: False
nctId: NCT06365554 id: 2 briefTitle: On-Premise and Remote Robotic Neurointervention overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-01-01 date: 2025-06-01 date: 2024-04-15 date: 2024-04-15 name: Remedy Robotics, Inc. class: INDUSTRY name: Unity Health Toronto briefSummary: This study is a prospective, single arm, single-center study to evaluate the safety and feasibility of the Remedy Robot for on premise and remote robotic Neurointervention. conditions: Cerebrovascular Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DEVICE_FEASIBILITY masking: NONE count: 10 type: ESTIMATED name: Remedy Robot measure: Procedural safety measure: Procedural Technical Success sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06365541 id: GYLLPJ-2024006 briefTitle: The Efficacy and Safety of Dapagliflozin in Improving Heart Failure in Dialysis Patients overallStatus: RECRUITING date: 2024-03-01 date: 2024-08-31 date: 2024-08-31 date: 2024-04-15 date: 2024-04-15 name: The People's Hospital of Gaozhou class: OTHER briefSummary: Dialysis patients have a higher incidence of cardiovascular events and require more effective measures to delay the progression of heart failure. Many studies have shown that dapagliflozin has cardioprotective effect, but most studies focus on non-dialysis patients with eGFR more than 20ml/min/1.73m2. However, the data on patients with eGFR less than 20ml/min/1.73m2 or dialysis patients, especially peritoneal dialysis patients, is less. Exploring the efficacy and safety of Dapagliflozin in improving heart failure in dialysis patients is of great clinical significance. conditions: The Efficacy and Safety of Dapagliflozin in Improving Heart Failure in Dialysis Patients studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Exploring the efficacy and safety of dapagliflozin in improving heart failure in dialysis patients by the analysis and comparison of patients' own data before and after dapagliflozin treatment primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: Dapagliflozin measure: N-terminal B-type natriuretic peptide precursor (NT-proBNP) measure: Left ventricular ejection fraction (LVEF) sex: ALL minimumAge: 20 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The People's Hospital of Gaozhou status: RECRUITING city: Maoming state: Guangdong zip: 525200 country: China name: Mingsheng Zhu role: CONTACT phone: 15016656405 email: ms160@163.com lat: 21.65 lon: 110.9 hasResults: False
nctId: NCT06365528 id: 2023-0232 briefTitle: Tunneled Peripherally Inserted Central Catheter (PICC) in Adult Patients and Associated Outcomes overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2025-12-31 date: 2026-07-31 date: 2024-04-15 date: 2024-04-15 name: Hospital de Clinicas de Porto Alegre class: OTHER name: Hospital Moinhos de Vento name: Irmandade Santa Casa de Misericórdia de Porto Alegre briefSummary: The aim of this multicenter randomized clinical trial is to compare the tunneling technique of PICC insertion with the non-tunneled insertion technique in the incidence of the combined or isolated outcome of catheter-related bloodstream primary infection, thrombosis, obstruction, and accidental dislodgement in the adult population within a period of up to 30 days. conditions: CLABSI - Central Line Associated Bloodstream Infection conditions: Deep Vein Thrombosis conditions: Dislodged Catheter conditions: Occlusion conditions: Catheter Rupture conditions: Catheter (Other); Complications studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE maskingDescription: Prospective Randomized Open, Blinded End-point (PROBE Study) whoMasked: OUTCOMES_ASSESSOR count: 840 type: ESTIMATED name: Subcutaneous tunnelling name: Non-tunnelling measure: End of therapy or catheter removal free from complications sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital de Clínicas de Porto Alegre city: Porto Alegre country: Brazil name: Eneida R Rabelo da Silva, ScD role: CONTACT lat: -30.03306 lon: -51.23 hasResults: False
nctId: NCT06365515 id: TUE010_IRTG_P5 briefTitle: Dopamine, Reward Learning and Sex Hormones overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-12 date: 2025-12 date: 2024-04-15 date: 2024-04-15 name: University Hospital Tuebingen class: OTHER name: German Research Foundation name: Uppsala University briefSummary: Hormonal transition periods during the menstrual cycle may predispose women to mental disorders. Hormonal fluctuations provide specific neuroendocrine conditions that modulate brain structure and function and these actions affect cognitive and emotional behaviors and affect energy and mood homeostasis. It is thought that these changes are driven by altered dopamine transmission. Here, we aim to examine (1) how sex hormones and dopamine are linked and also (2) how hormonal changes affect motivation, mood, and energy homeostasis.
The investigator hypothesizes that women in EF cycle phase (1) have naturally less dopamine and show less effort, and (2) they show greater improvement in effort-based decision-making after Levodopa administration. We have exploratory outcomes about (3) sex differences in reward-learning with and without Levodopa administration and explore if these differences correlate with elevated female sex hormone levels. Moreover, it is hypothesized that (4) hormonal fluctuations affect energy homeostasis, thus women in their EF cycle phase have higher energy expenditure and (5) they report more negative mood than in their mid-luteal (ML) cycle phase. conditions: Hormonal Changes conditions: Menstrual Cycle studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: The investigators will assess the effects of Levodopa administration on reward-learning using a double-blind randomized cross-over design. In a within-subject design, participants will get both conditions (Levodopa/placebo) at different time points (a few days apart). After drug/placebo administration we will assess cerebral blood flow and functional connectivity at rest (via functional MR imaging) during effort-based decision making task. primaryPurpose: BASIC_SCIENCE masking: TRIPLE maskingDescription: Neither participants nor investigators will know at which time point the participant will receive Levodopa and placebo tablets. The tablets will be prepared by independent members of the university hospital. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: Levodopa administration name: Placebo administration measure: Motivation to work for rewards: force of pressing grip force device (GFD) to gain food and monetary rewards circuitry during effort-based decision-making measure: Reward-related brain responses in the reward network during effort-based decision-making measure: Reward anticipation on a neural level measure: Execution of effort on a neural level measure: Resting-state functional connectivity measure: Changes in reinforcement learning measure: Menstrual cycle induced changes in mood and food cravings measure: Changes in resting energy expenditure measure: Changes in metabolic hormone levels during the menstrual cycle sex: ALL minimumAge: 20 Years maximumAge: 35 Years stdAges: ADULT facility: Department of Psychiatry & Psychotherapy, University of Tübingen city: Tübingen state: BW zip: 72076 country: Germany name: Andrea Heberle role: CONTACT email: Andrea.Heberle@med.uni-tuebingen.de lat: 48.52266 lon: 9.05222 hasResults: False
nctId: NCT06365489 id: 113293 briefTitle: Comparison of Brachial Wrist Index Before and After Implantation of Arteriovenous Fistulas, Based on Brachial Artery overallStatus: ACTIVE_NOT_RECRUITING date: 2022-12-11 date: 2023-02-20 date: 2024-09 date: 2024-04-15 date: 2024-04-15 name: Golestan University of Medical sciences class: OTHER briefSummary: Arterio-Venous Fistula (AVF) is the most recommended vascular access for hemodialysis. Steal syndrome is a potential complication of AVF implantation and occurs secondary to diversion of the arterial flow of a limb to the venous system resulting in limb ischemia. Measuring wrist pressure compared to arm pressure before and after fistula implantation can be a suitable tool in predicting the possibility of Steal syndrome. In this study, the ratio of wrist to arm pressure and its relationship with Steal syndrome symptoms before and after fistula implantation are investigated. conditions: Vascular Access Complication studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 78 type: ACTUAL measure: Early post operative WBI changes following AVF implantation measure: Two-week post operative WBI changes following AVF implantation measure: Three-month post operative WBI changes following AVF implantation measure: Correlation between WBI changes following AVF implantation with age measure: Correlation between WBI changes following AVF implantation with sex measure: Correlation between WBI changes following AVF implantation with co-morbidities measure: Correlation between WBI changes following AVF implantation with steal syndrome sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pezhman Kharazm, MD city: Gorgan state: Golestan zip: 4917956808 country: Iran, Islamic Republic of lat: 36.8427 lon: 54.44391 hasResults: False
nctId: NCT06365476 id: 202309126RIND briefTitle: FlexWave Trial: Efficacy of Extracorporeal Shock Wave Therapy in Post-Stroke Upper Limb Spasticity overallStatus: RECRUITING date: 2024-04-15 date: 2026-04-15 date: 2027-04-15 date: 2024-04-15 date: 2024-04-22 name: National Taiwan University Hospital class: OTHER briefSummary: Extracorporeal shock wave therapy (ESWT) has emerged as an effective therapeutic intervention for addressing post-stroke limb spasticity. This research aims to explore the therapeutic implications of focused ESWT for wrist and finger flexor muscles in patients suffering from post-stroke upper limb spasticity. conditions: Stroke conditions: Spasticity, Muscle studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: focused extracorporeal shock wave therapy (ESWT) measure: passive range of motion for the wrist and finger joints measure: hand grip strength measure: Visual Analogue Scale (VAS) measure: modified Ashworth scale (MAS) measure: modified Tardieu scale (MTS) measure: Fugl-Meyer Assessment for the Upper Extremity (FMA-UE) measure: Action Research Arm Test (ARAT) measure: Barthel index measure: Functional Independence Measure (FIM) measure: ultrasound assessment measure: Box and Block Test measure: Wolf Motor Function Test sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Physical Medicine & Rehabilitation , National Taiwan University Hospital status: RECRUITING city: Taipei zip: 100 country: Taiwan name: Shu-mei Yang, MD role: CONTACT phone: 886-2- 23123456 email: b99401109@gmail.com name: Shu-mei Yang, MD role: PRINCIPAL_INVESTIGATOR lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06365463 id: URIS202401 briefTitle: Telerehabilitation to Improve Balance and Mobility in Patients After Stroke acronym: TeleHome overallStatus: RECRUITING date: 2024-04-09 date: 2024-05-31 date: 2024-05-31 date: 2024-04-15 date: 2024-04-23 name: University Rehabilitation Institute, Republic of Slovenia class: OTHER briefSummary: Telerehabilitation is an effective rehabilitation method that allows patients to receive physiotherapy remotely in their homes. The purpose of this study was to investigate the effects of home-based remote group training for balance and mobility on activities and body functions. conditions: Hemorrhagic Stroke conditions: Ischemic Stroke studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 16 type: ESTIMATED name: Telerehabilitation measure: Change in balance measure: Change in limits of stability measure: Change in weight-bearing symmetry measure: Change in mobility measure: Change in walking speed measure: Satisfaction with the remote training sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Rehabilitation Institute, Republic of Slovenia status: RECRUITING city: Ljubljana zip: 1000 country: Slovenia name: Urška Puh, PT, PhD role: CONTACT phone: +386 1 4758152 email: urska.puh@ir-rs.si lat: 46.05108 lon: 14.50513 hasResults: False
nctId: NCT06365450 id: IRB00315481 briefTitle: Breast and Cervical Cancer Education Program acronym: OCEAP overallStatus: COMPLETED date: 2022-09-22 date: 2024-02-28 date: 2024-04-05 date: 2024-04-15 date: 2024-04-15 name: Johns Hopkins University class: OTHER name: Older Women Embracing Life name: The John G. Bartlett Specialty Practice briefSummary: The primary goal of this study is to improve cancer literacy in Black women living with HIV and ultimately improve breast and cervical cancer screening uptake. This study involves an educational intervention delivered virtually and in person, depending on the participants' preference. conditions: Cervical Cancer conditions: Breast Cancer conditions: Health Behavior studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Each participant is required to attend (in person or virtually via Zoom) two educational sessions one on breast cancer and the other on cervical cancer. primaryPurpose: OTHER masking: NONE count: 60 type: ACTUAL name: Educational Intervention measure: Health Literacy in Cancer Screening as assessed by the Assessment of Health Literacy in Cancer Screening (AHL-C) tool. measure: Number of participants recruited from each community partner measure: Number of participants who preferred virtual or in person sessions measure: Number of participants who were lost of follow up measure: Number of participants who needed help redeeming their gift codes sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Johns Hopkins University School of Nursing city: Baltimore state: Maryland zip: 21205 country: United States lat: 39.29038 lon: -76.61219 hasResults: False
nctId: NCT06365437 id: TCD601B101 briefTitle: A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation overallStatus: RECRUITING date: 2021-06-06 date: 2025-08 date: 2025-08 date: 2024-04-15 date: 2024-04-15 name: ITB-Med LLC class: INDUSTRY briefSummary: The purpose of this study is to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of escalating doses of TCD601 when compared to rATG in de novo renal transplant patients. conditions: Kidney Transplantation studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: BASIC_SCIENCE masking: NONE count: 40 type: ESTIMATED name: TCD601 name: Tacrolimus (TAC) name: Corticosteroids (CS) name: Mycophenolate Mofetil (MMF) name: ATG measure: Number of participants with treatment-related adverse events as assessed by CTCAE v5.0. measure: Measure Peak Plasma Concentration (Cmax) over time. measure: Measure the Area under the plasma concentration versus time curve (AUC). measure: Assess changes in peripheral immunophenotype, including T-, B-, and NK-cells, via Fluorescence-activated Cell Sorter (FACS) over time. measure: Measure anti-TCD601 antibodies in serum via Enzyme-linked Immunosorbent (ELISA) assay over time. measure: Measure peripheral CD2-receptor occupancy following TCD601 administration Receptor Occupancy will be reported as the % of target saturation. sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Innsbruck Medical University status: RECRUITING city: Innsbruck zip: A-6020 country: Austria name: Research Coordinator role: CONTACT lat: 47.26266 lon: 11.39454 facility: University of Vienna status: RECRUITING city: Vienna zip: 1090 country: Austria name: Research Coordinator role: CONTACT lat: 48.20849 lon: 16.37208 facility: Hospital Clinic de Barcelona status: RECRUITING city: Barcelona zip: 08036 country: Spain name: Research Coordinator role: CONTACT lat: 41.38879 lon: 2.15899 facility: Hospital Universitari de Bellvitge status: RECRUITING city: Barcelona zip: 08907 country: Spain name: Research Coordinator role: CONTACT lat: 41.38879 lon: 2.15899 facility: Karolinska University Hospital status: RECRUITING city: Stockholm state: Huddinge zip: 14157 country: Sweden name: Research Coordinator role: CONTACT lat: 59.33258 lon: 18.0649 facility: Sahlgrenska University Hospital status: RECRUITING city: Göteborg zip: 41345 country: Sweden name: Research Coordinator role: CONTACT lat: 57.70716 lon: 11.96679 facility: Skåne University Hospital status: RECRUITING city: Malmö zip: 20502 country: Sweden name: Research Coordinator role: CONTACT lat: 55.60587 lon: 13.00073 hasResults: False
nctId: NCT06365424 id: KY20151230-5-1 briefTitle: Fenofibrate in Patients With Primary Biliary Cholangitis (PBC) overallStatus: RECRUITING date: 2017-04-08 date: 2027-04 date: 2027-04 date: 2024-04-15 date: 2024-04-15 name: Xijing Hospital of Digestive Diseases class: OTHER briefSummary: An Open Label Long-Term Study to Evaluate the Safety and Effectiveness of Fenofibrate in Subjects with Primary Biliary Cholangitis (PBC) conditions: Primary Biliary Cholangitis studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 117 type: ESTIMATED name: Fenofibrate name: UDCA measure: Treatment emergent adverse events (TEAEs) measure: Percentage of patients with biochemical response sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Xijing Hospital status: RECRUITING city: Xi'an state: Shaanxi country: China name: Ying Han role: CONTACT lat: 34.25833 lon: 108.92861 hasResults: False
nctId: NCT06365411 id: GEM-KiT briefTitle: GEnomic Medicine in Kidney Transplantation Study acronym: GEM-KiT overallStatus: NOT_YET_RECRUITING date: 2024-06-03 date: 2030-01-01 date: 2035-01-01 date: 2024-04-15 date: 2024-04-24 name: Western Sydney Local Health District class: OTHER briefSummary: Investigator led, prospective, observational cohort study to detect genomic features which can predict outcomes following kidney transplantation.