* answer daily surveys about how they are feeling and functioning. conditions: Arthritis of Carpometacarpal Joint of Left Thumb conditions: Arthritis of Carpometacarpal Joint of Right Thumb studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: The study design will be a double-blind, randomized controlled trial with crossover. primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Double-blind Randomized Controlled Trial whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Curcumin name: Placebo measure: Change from Baseline in Pain on the Visual Analog Pain (VAS) Score measure: Change from Baseline in Pain on the Visual Analog Pain (VAS) Score - crossover condition measure: Change from Baseline in Normal Function on the Single Assessment Numerical Evaluation (SANE) Score measure: Change from Baseline in Normal Function on the Single Assessment Numerical Evaluation (SANE) Score - crossover condition measure: Change from Baseline in Quality of Life on the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health-10 Score measure: Change from Baseline in Quality of Life on the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health-10 Score - crossover condition measure: Change from Baseline in Pain interference on the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference Score measure: Change from Baseline in Pain interference on the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference Score - crossover condition measure: Change from Baseline in Pain interference on the Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity (UE) Score measure: Change from Baseline in Pain interference on the Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity (UE) Score measure: Change from Baseline in Pain on the Australian/Canadian Hand Osteoarthritis (AUSCAN) Index measure: Change from Baseline in Pain on the Australian/Canadian Hand Osteoarthritis (AUSCAN) Index measure: Change from Baseline in Disability on The Quick Disability of the Arm, Shoulder (QuickDASH). measure: Change from Baseline in Disability on The Quick Disability of the Arm, Shoulder (QuickDASH) - crossover condition measure: Change from Baseline in perseverance on the Brief Resilience Index (BRI) measure: Change from Baseline in perseverance on the Brief Resilience Index (BRI) - crossover condition measure: Number of Participants With Treatment-Related Adverse Events measure: Change from Baseline in the Mean Seated Trough Cuff Systolic Blood Pressure measure: Change from Baseline in heart rate measure: Change from Baseline in the Mean Seated Trough Cuff Systolic Blood Pressure measure: Change from Baseline in heart rate measure: Change from baseline in serum liver panel parameters: Alanine transaminase (ALT), Alkaline phosphatase (ALP) and Aspartate aminotransferase (AST) measure: Change from baseline in serum comprehensive metabolic panel (CMP) parameters: glucose, blood urea nitrogen (BUN), Creatinine, Calcium measure: Change from baseline in serum comprehensive metabolic panel (CMP) parameters: estimated glomerular filtration rate (eGFR) measure: Change from baseline in serum comprehensive metabolic panel (CMP) parameters: Bilirubin measure: Change from baseline in serum comprehensive metabolic panel (CMP) parameters: Sodium, Potassium, Chloride, Carbon Dioxide measure: Change from baseline in serum comprehensive metabolic panel (CMP) parameters: Protein, Albumin measure: Change from baseline in serum comprehensive metabolic panel (CMP) parameters: Prothrombin time- International normalized ratio (PT-INR) measure: Change from baseline in serum complete blood count (CBC) parameters: Red Blood Cells (CBC), White Blood Cells (WBC), Platelets measure: Change from baseline in serum complete blood count (CBC) parameters: Hemoglobin measure: Change from baseline in serum complete blood count (CBC) parameters: Hematocrit measure: Change from baseline in serum complete blood count (CBC) parameters: Mean Corpuscular Volume (MCV) measure: Change from baseline in serum complete blood count (CBC) parameters: the amount of hemoglobin per red blood cell.(MCH) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False