hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06286748 id: DeniseMafra19 briefTitle: Beetroot Extract Supplementation Associated With an Exercise Protocol for Chronic Kidney Disease Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-12-10 date: 2024-12-10 date: 2024-02-29 date: 2024-02-29 name: Universidade Federal Fluminense class: OTHER briefSummary: Chronic kidney disease (CKD) patients often present systemic inflammation and oxidative stress, resulting in metabolic disorders and high rates of disease-associated cardiovascular death. The literature has indicated that dietary control, the use of bioactive compounds, and the practice of regular physical exercise are essential for the prevention and management of CKD and its complications. In this context, beetroot (Beta vulgaris rubra) deserves attention as it is a source of several bioactive compounds, such as nitrate, betaine, and betalain, with beneficial effects for CKD patients, including anti-inflammatory, antioxidant effects, reduction of blood pressure, and vasodilatory action. The antioxidant and anti-inflammatory properties, in addition to their vasodilatory and antihypertensive capacity, can make supplementation of beetroot an excellent nutritional strategy to help in the treatment of CKD patients. So, this research project will bring contributions to the scientific world, providing strategies for application in clinical practice and the care of patients with CKD, on the use of beetroot associated with an exercise protocol as a non-pharmacological strategy in modulating inflammation, oxidative stress, and improved functional capacity. Furthermore, when supplemented hours before physical training, has been identified as an important factor in improving performance in these activities. Therefore, this study aims to evaluate the effects of supplementation (acute and chronic) of beetroot extract associated with an exercise protocol on complications associated with CKD. conditions: Chronic Kidney Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 25 type: ESTIMATED name: Beetroot juice name: Placebo measure: Change individual quality of life measure: Change physical activity level sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06286735 id: DeniseMafra18 briefTitle: Effects of Cinnamomum Supplementation in Chronic Kidney Disease Patients overallStatus: NOT_YET_RECRUITING date: 2024-06-22 date: 2024-11-22 date: 2024-12-22 date: 2024-02-29 date: 2024-03-25 name: Universidade Federal Fluminense class: OTHER briefSummary: Patients with chronic kidney disease (CKD) experience many complications related to inflammation and oxidative stress that are closely related to the progression of kidney failure and increased mortality. Furthermore, these patients may have intestinal dysbiosis associated with persistent uremia, generating greater production of uremic toxins arising from the metabolism of intestinal bacteria and also helping to maintain the inflammatory process and oxidative stress. In this context, some nutritional strategies have been proposed as an adjuvant therapeutic alternative to modulate inflammation and improve the antioxidant response of patients with CKD, and even more so to modulate the intestinal microbiota. Based on the consolidated knowledge of the role of nutrients and bioactive compounds on the expression of genes related to inflammation, oxidative stress, and also the modulation of the intestinal microbiota, cinnamon, a member of the Lauraceae family, has been widely used as a spice and traditional herbal medicine for centuries and has indicated beneficial benefits in cardiovascular diseases, obesity, diabetes. The bioactive compounds in cinnamomum, such as cinnamaldehyde, cinnamic acid, and cinnamate, can attenuate oxidative stress, inflammation, hyperglycemia, intestinal dysbiosis, and dyslipidemia, which are common complications in CKD patients. Therefore, the present project proposes a longitudinal clinical trial study that aims to evaluate the effects of cinnamomum on transcription factors and inflammatory markers, oxidative stress and modulation of intestinal health in patients with CKD on hemodialysis. conditions: Chronic Kidney Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 30 type: ESTIMATED name: cinnamomum name: Placebo measure: Concentration of Nuclear factor kappa B (NF-KB) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06286722 id: LollandCD briefTitle: Optimized Rehabilitation of Older Adults With Hip Fracture and Signs of Cognitive Impairment - Feasibility Study acronym: ENHANCE overallStatus: RECRUITING date: 2024-02-08 date: 2025-06-30 date: 2025-06-30 date: 2024-02-29 date: 2024-02-29 name: Lolland Community, Denmark class: OTHER name: Vordingborg Municipality name: Stevns Municipality name: Guldborgsund Municipality briefSummary: Older adults suffering from a hip fracture are a significant concern, with higher incidence rates among women. Mortality rates post-hip fracture are alarming, with up to 8-fold increased risk within 3 months and significant percentages within 30 days and 12 months. Older adults with hip fracture face challenges in regaining pre-fracture level of function, especially those with cognitive impairment, which affects 25% to 40% of cases and increases mortality risk. While interventions exist, such as progressive strength training and structured exercise programs, patients with hip fracture don't consistently restore pre-fracture function, particularly in cognitively impaired patients, who are often excluded from studies. Limited evidence exists on effective management for this subgroup, with a lack of clarity on community-based rehabilitation. Although guidelines suggest exercise interventions for patients with mild to moderate cognitive impairment, the specifics remain uncertain due to insufficient research focused solely on this population.
This feasibility study aims to assess the practicality and safety of implementing a 12-week individualized, progressive exercise program for older adults with hip fracture and cognitive impairment in an outpatient setting. Additionally, the investigators seek to gather qualitative insights through observations and interviews regarding participants' experiences and the perceived value of rehabilitation post-hip fracture, particularly focusing on the exercise intervention provided. conditions: Hip Fractures conditions: Cognitive Impairment studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Feasibility study primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Progressive, individualized and structured exercise program measure: The New Mobility Score measure: Mini Mental State Examination measure: Height measure: Weight measure: Tandem balance test measure: The Barthel-20 measure: 30 sec chair raise test measure: Brief Assessment of Impaired Cognition Questionaire measure: Handgrip strength measurement measure: The Cumulated Ambulation Score measure: Four meter walk test measure: Euroqol 5 dimensions measure: Clinical Frailty Scale measure: The Verbal Rating Scale measure: Activity accelerometers sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Stevns Healthcare Center, Stevns Municipality status: NOT_YET_RECRUITING city: Hårlev zip: 4652 country: Denmark name: Lotte Bylov role: CONTACT email: jover@lolland.dk lat: 55.34936 lon: 12.23382 facility: Maribo Health Center, Lolland Municipality status: RECRUITING city: Maribo zip: 4930 country: Denmark name: Jan Arnholtz Overgaard, MSc. role: CONTACT phone: +4554677700 email: jover@lolland.dk name: Gwen Tremmel role: CONTACT phone: +4554677700 email: gptr@lolland.dk name: Jan A Overgaard, MSc. role: PRINCIPAL_INVESTIGATOR lat: 54.77662 lon: 11.50017 facility: Guldborgsund Healthcare Center, Guldborgsund Municipality status: RECRUITING city: Nykøbing Falster zip: 4800 country: Denmark name: Cecilie Kristensen role: CONTACT email: jover@lolland.dk lat: 54.76906 lon: 11.87425 facility: Vordingborg Healthcare Center, Vordingborg Municipality status: RECRUITING city: Vordingborg zip: 4760 country: Denmark name: Line Flemmer, Bachelor role: CONTACT email: jover@lolland.dk lat: 55.00801 lon: 11.91057 hasResults: False
nctId: NCT06286696 id: NL84914.058.23 briefTitle: Optic Nerve Sheath Diameter in Hypertensive Emergency acronym: OpticUS overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-07-01 date: 2024-02-29 date: 2024-02-29 name: Leiden University Medical Center class: OTHER briefSummary: This prospective observational study investigates the potential of point-of-care ultrasonography of the optic nerve sheath diameter (ONSD) to rule out papilledema in patients with suspected hypertensive emergency. The primary focus is on assessing ONSD sensitivity in identifying papilledema (hypertensive retinopathy grade 4), while secondary endpoints include hypertensive retinopathy grade 3, hypertensive encephalopathy, and the need for intravenous rapid-acting medications to lower elevated blood pressure. This study aims to determine the diagnostic characteristics of this procedure for the diagnosis of hypertensive retinopathy, thus assessing its potential as a screening tool to rule out hypertensive retinopathy by the acute internal medicine doctor. conditions: Hypertensive Emergency conditions: Papilledema conditions: Hypertension studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 375 type: ESTIMATED name: Optic Nerve Sheath Diameter measure: Papilledema measure: Hypertensive retinopathy grade 3 & 4 combined measure: Hypertensive encephalopathy measure: Rapid acting medications administered intravenously to lower the elevated blood pressure measure: Presence of a bulging optic nerve disc and/or crescent sign found by ultrasonography of the optic nerve sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06286683 id: APHP231706 briefTitle: Impact of Early Mobilization on SAH Patients Physiological Parameters acronym: MOBALPAH overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2027-02 date: 2027-02 date: 2024-02-29 date: 2024-03-08 name: Assistance Publique - Hôpitaux de Paris class: OTHER briefSummary: The aim of the study is to evaluate the physiological response to out-of-bed mobilization in patients admitted to the intensive care unit for subarachnoid hemorrhage. More specifically, the aim is to measure the impact on cerebral perfusion, lung aeration, cardiovascular and respiratory parameters. conditions: Subarachnoid Hemorrhage studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: lung ultrasound name: Transcranial Doppler name: near-infrared spectroscopy (NIRS) name: clinical examination measure: Impact on lung aeration measure: Impact on cerebral blood flow measure: Impact on cerebral tissue oxygenation measure: Impact on heart rate measure: Impact on arterial pressure measure: Impact on Saturation measure: Impact on neurological examination measure: Impact on patient comfort sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Adéla FOUDHAÏLI city: Paris zip: 75010 country: France lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06286670 id: IRB00108312 id: HT94252311075 type: OTHER domain: Department of Defense briefTitle: Single Versus Dual Implant Fixation of Distal Femur Fractures acronym: PRORP overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-12 date: 2027-12 date: 2024-02-29 date: 2024-04-16 name: Wake Forest University Health Sciences class: OTHER name: United States Department of Defense briefSummary: The goal of this clinical trial is to compare two types of surgical fixation in patients with specific kinds of distal femur fractures. The main questions it aims to answer is which operation for distal femur fractures is better for efficient return to work and everyday activities. conditions: Articular Fractures studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: adult patients with extra-articular or complete articular distal femur fractures that will be operatively treated recruited from one of the participating sites during the index hospitalization primaryPurpose: TREATMENT masking: NONE count: 144 type: ESTIMATED name: Single Implant Fixation name: Dual Implant Fixation measure: Return to Work - International Physical Activity Questionnaire (IPAQ) Scores measure: Return to Work - International Physical Activity Questionnaire (IPAQ) Scores measure: Return to Work - International Physical Activity Questionnaire (IPAQ) Scores measure: Return to Work - International Physical Activity Questionnaire (IPAQ) Scores measure: Number of Unions measure: Number of Resource Utilizations measure: Number of Reoperations measure: Number of Complications measure: Time to Walking Without an Assistive Device measure: Prescribed Weight Bearing Status measure: Fear of Movement - Change in Tampa Scale for Kinesiophobia (TSK) Scores measure: Health Related Quality of Life - Change in Patient-Reported Outcomes Measurement Information System (PROMIS) Scores measure: Global Health Status - Change in Veterans RAND 12 Item Health Survey (VR12) Scores measure: Change in the Work Productivity and Activity Impairment Questionnaire Scores measure: Change in Numeric Pain Rating measure: Change in Pain Inventory (BPI) measure: Change in Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Subscale--Pain Interference measure: Presence of Post-Traumatic Arthritis (PTOA) - Kellgren Lawrence (KL) classification measure: Presence of Post-Traumatic Arthritis (PTOA) - Paley Grading System (PGS measure: Isokinetic Knee Flexion/Extension Strength Testing measure: Counter-Movement Jump measurement measure: Single Leg Static and Dynamic Postural Stability Index measure: Triple Hop Performance Assessment sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Atrium Health Musculoskeletal Institute city: Charlotte state: North Carolina zip: 28204 country: United States name: Erica Grochowski role: CONTACT email: Erica.Grochowski@atriumhealth.org name: Laurence Kempton, MD role: PRINCIPAL_INVESTIGATOR lat: 35.22709 lon: -80.84313 hasResults: False
nctId: NCT06286657 id: UVienna23a briefTitle: Xanthohumol and Viral Infections (XL) overallStatus: RECRUITING date: 2023-08-01 date: 2024-04-30 date: 2024-12-30 date: 2024-02-29 date: 2024-02-29 name: University of Vienna class: OTHER briefSummary: The aim of the present study is to determine if a regular oral supplementation of xanthohumol attenuate the severity of symptoms and duration of´viral infections. conditions: Infection Viral studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 100 type: ESTIMATED name: Xanthohumol name: Placebo measure: Changes in severity and duration of viral infections measure: Changes in blood lipid levels measure: Changes in cognitive skills sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Vienna status: RECRUITING city: Vienna zip: 1090 country: Austria name: Ina Bergheim, Prof. Dr. role: CONTACT phone: +43-1-4277-54981 email: ina.bergheim@univie.ac.at lat: 48.20849 lon: 16.37208 hasResults: False
nctId: NCT06286644 id: UVienna23 briefTitle: Hop Compounds on the Immune System (VH) overallStatus: RECRUITING date: 2022-05-30 date: 2024-05-30 date: 2024-12-30 date: 2024-02-29 date: 2024-02-29 name: University of Vienna class: OTHER briefSummary: The aim of the present study is to determine the effect of Iso-alpha-Acids and Xanthohumol from hops on the immune response of healthy participants over a timeframe of 6 hours. conditions: Inflammatory Response studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 14 type: ESTIMATED name: Xanthohumol name: Iso-alpha-Acids name: Xanthohumol + Iso-alpha-Acids measure: Changes in parameters of immune response measure: Changes in parameters of immune response sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Vienna status: RECRUITING city: Vienna zip: 1090 country: Austria name: Ina Bergheim, Prof. Dr. role: CONTACT phone: +431427754981 email: ina.bergheim@univie.ac.at lat: 48.20849 lon: 16.37208 hasResults: False
nctId: NCT06286618 id: HHSN268201800015I briefTitle: Nutrition360: Moving to Integrated and Holistic Disease Prevention Among Underserved Mississippians overallStatus: ACTIVE_NOT_RECRUITING date: 2022-09-01 date: 2024-08-31 date: 2024-08-31 date: 2024-02-29 date: 2024-02-29 name: University of Southern Mississippi class: OTHER name: My Brother's Keeper briefSummary: The objective for the study is to implement a pilot study to establish essential components to address diet quality in healthcare settings and examine what value an integrated service model delivery has for the primary prevention of cardiometabolic diseases with an initial focus on dietary behaviors. This objective will be met by 1: Utilizing a multiphase optimization study design to select and optimize essential components to address diet behaviors and 2: Comparing an integrated and referral-based delivery model for healthcare-based strategies that address structural and psychosocial barriers to a healthy diet for racial/ethnic minority, marginalized and disadvantaged background young to middle aged adult populations in Mississippi. conditions: Cardiovascular Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: HEALTH_SERVICES_RESEARCH masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 24 type: ACTUAL name: Psychosocial Intervention name: Structural Intervention name: Traditional Psychosocial+Structural name: Integrated Psychosocial+Structural measure: Participant Burden measure: Diet Quality measure: cost effectiveness sex: ALL minimumAge: 25 Years maximumAge: 50 Years stdAges: ADULT facility: The University of Southern Mississippi city: Hattiesburg state: Mississippi zip: 39406-0001 country: United States lat: 31.32712 lon: -89.29034 hasResults: False
nctId: NCT06286605 id: UNISS_PHD_Osstem_4 briefTitle: RCT GBR One Stages Comparing A-Oss and Autogenous Bone Versus A-Oss and LCR-A overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-12-30 date: 2028-12-30 date: 2024-02-29 date: 2024-02-29 name: Università degli Studi di Sassari class: OTHER name: Dr. Dario Melodia name: Dr. Milena Pisano name: Dr. Aurea Lumbau name: Prof. Silvio Mario Meloni name: Prof. Edoardo Baldoni briefSummary: The aim of this randomized controlled trial is to evaluate the tridimensional bone stability after horizontal one-stage GBR using collagene membrane (OssMem) with a mix of Bovine Bone Substitute (A-Oss) and autogenous bone (test group) versus A-Oss and LCR-A, a synthetic bone (control group). conditions: Guided Bone Regeneration conditions: Dental Implant studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Multicenter, randomized controlled trial of parallel-group design. primaryPurpose: TREATMENT masking: NONE count: 42 type: ESTIMATED name: A-oss and autogenous bone name: A-oss an LCR-A measure: Rate of Implants survival measure: Number of Participants with prosthesis failure measure: Number of complications measure: Horizontal and volumetric dimensional changes measure: Rate of peri-implant marginal bone level measure: Plaque Index and bleeping on probing measure: Valuation of patient satisfaction measure: Valuation of soft tissue thickness and amount of keratinized tissue measure: Rate of pes score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Marco Tallarico city: Sassari zip: 07100 country: Italy name: Dario Melodia, Dr role: CONTACT phone: 3331226618 email: dariomld1@gmail.com name: Marco Tallarico, Prof role: CONTACT phone: 3280758769 email: me@studiomarcotallarico.it lat: 40.72586 lon: 8.55552 hasResults: False
nctId: NCT06286592 id: Pro2023002053 briefTitle: LUNGevity: Lung Cancer Stigma Community Based Participatory Research overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-11 date: 2025-11 date: 2024-02-29 date: 2024-03-29 name: Rutgers, The State University of New Jersey class: OTHER briefSummary: Lung cancer survival rates are low for intersectional underserved groups. Lung cancer stigma and intersectional stigma related to minoritized group status leads to increased morbidity and mortality and health disparities. Mindfulness interventions have been shown to decrease stigma and the negative impacts of stigma, however, these interventions have never been tested to decrease lung cancer stigma specifically. In this study, the investigators will use Community Based Participatory Research framework and MOST methodology to build and optimize a brief virtual mindfulness intervention to decrease lung cancer stigma, through first building a diverse coalition of lung cancer patients on a participatory action council. conditions: Lung Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL interventionModelDescription: Details of the specific interventions will be selected in collaboration with the Community Advisory Board.
Then, in a Phase IB trial, we will use a MOST design to assign patients to promising intervention components, combining them and altering exposure time, measuring preliminary effects of possible components of interventions. Details of the specific interventions will be selected in collaboration with the Community Advisory Board. primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Ultra-brief mindfulness intervention video name: Forgiveness video name: ACT values video measure: Lung Cancer Stigma Inventory (LCSI) measure: Tobacco use quit likelihood sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06286579 id: UNISS_PHD_Osstem_3 briefTitle: SOI Immediately vs Delayed overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-12-31 date: 2028-01-31 date: 2024-02-29 date: 2024-02-29 name: Università degli Studi di Sassari class: OTHER name: Dr. Dario Melodia name: Dr. Milena Pisano name: Dr. Aurea M. I. Lumbau name: Prof. Silvio Mario Meloni name: Prof. Edoardo Baldoni briefSummary: The aim of this randomized controlled trial is to compare the clinical and radiographic of immediately loaded, immediate (post-extractive, test group) versus delayed (control group) implants with new SOI surface conditions: Dental Implant conditions: Dental Implant-Abutment Design studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomised controlled trial of parallel group design. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: One "blinded (when possible)" independent assessor whoMasked: OUTCOMES_ASSESSOR count: 70 type: ESTIMATED name: Immediately implant placement name: Delayed measure: Number of prosthesis failure measure: Number of implant failure measure: Number of complications measure: Rate of peri-implant marginal bone level changes measure: Valuation of patient satisfaction measure: Rate of implant stability quotient (ISQ) measure: Valuation of soft tissue thickness and amount of keratinized tissue measure: Number of PES score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Marco Tallarico city: Sassari zip: 07100 country: Italy lat: 40.72586 lon: 8.55552 hasResults: False