hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06334354 id: 23-320 briefTitle: A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC) acronym: TRAC overallStatus: RECRUITING date: 2024-03-19 date: 2029-03 date: 2029-03 date: 2024-03-28 date: 2024-04-26 name: Memorial Sloan Kettering Cancer Center class: OTHER briefSummary: The purpose of this study is to look at how differences in cognitive (mental) function develop over time in breast cancer survivors compared to volunteers without a history of cancer (healthy volunteers). Both cancer survivors and healthy volunteers (who are the same age as the cancer survivors) will participate in this study so the researchers can compare the results of neurocognitive testing (which looks at memory, attention, and information processing) on each group of participants. conditions: Breast Cancer Survivors studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 420 type: ESTIMATED name: Assessments name: Assessment (Survivors Only) name: APOE and DNA Isolation measure: examine cognitive effects measure: measure levels of smoking exposure sex: FEMALE minimumAge: 65 Years maximumAge: 80 Years stdAges: OLDER_ADULT facility: Memorial Sloan Kettering Basking Ridge (All Protocol Activities) status: RECRUITING city: Basking Ridge state: New Jersey zip: 07920 country: United States name: James Root, PhD role: CONTACT phone: 646-888-0035 lat: 40.70621 lon: -74.54932 facility: Memorial Sloan Kettering Monmouth (All protocol activities) status: RECRUITING city: Middletown state: New Jersey zip: 07748 country: United States name: James Root, PhD role: CONTACT phone: 646-888-0035 lat: 40.39652 lon: -74.09211 facility: Memorial Sloan Kettering Bergen (All Protocol Activities) status: RECRUITING city: Montvale state: New Jersey zip: 07645 country: United States name: James Root, PhD role: CONTACT phone: 646-888-0035 lat: 41.04676 lon: -74.02292 facility: Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities) status: RECRUITING city: Commack state: New York zip: 11725 country: United States name: James Root, PhD role: CONTACT phone: 646-888-0035 lat: 40.84288 lon: -73.29289 facility: Memorial Sloan Kettering Westchester (All Protocol Activities) status: RECRUITING city: Harrison state: New York zip: 10604 country: United States name: James Root, PhD role: CONTACT phone: 646-888-0035 lat: 40.96899 lon: -73.71263 facility: Memorial Sloan Kettering Cancer Center status: RECRUITING city: New York state: New York zip: 10065 country: United States name: James Root, PhD role: CONTACT phone: 646-888-0035 name: Tim Ahles, PhD role: CONTACT phone: 646-888-0048 name: James Root, PhD role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 facility: Memorial Sloan Kettering Nassau (All Protocol Activities) status: RECRUITING city: Uniondale state: New York zip: 11553 country: United States name: James Root, PhD role: CONTACT phone: 646-888-0035 lat: 40.70038 lon: -73.59291 hasResults: False
nctId: NCT06334328 id: 2205009237 briefTitle: Virtual Reality-based Mindful Movement Therapy for Seniors overallStatus: COMPLETED date: 2022-08-15 date: 2023-09-30 date: 2024-01-31 date: 2024-03-28 date: 2024-03-28 name: Drexel University class: OTHER briefSummary: The current proposal aims to 1) develop a technical platform and implementation plan for the delivery of a virtual reality-based mindful movement therapy (VR-MMT) protocol for older adults; and 2) conduct a clinical trial to examine the feasibility and preliminary efficacy of an 8-week, 16-session module VR-MMT intervention for this population. The findings of this study will help us to identify engagement barriers and refine the intervention contents as well as the study protocol necessary for the preparation of grant applications to conduct a controlled clinical trial. This study is innovative and high impact as this is the first study to examine the feasibility and preliminary efficacy of a VR-MMT intervention that could potentially ameliorate cognitive and mobility decline and promote psychological wellbeing in older adults by combining a widely accessible technology and creative embodiment-based approach. conditions: Cognitive Decline conditions: Physical Activity conditions: Psychological Wellbeing studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 12 type: ACTUAL name: Virtual reality based mindful movement therapy measure: Treatment adherence measure: Treatment acceptability measure: Treatment satisfaction measure: Qualitative feedback measure: Safety measure: Montreal Cognitive Assessment (MoCA) measure: Trail making test measure: The Warwick-Edinburgh Mental Well-being Scale (WEMWBS) measure: Physical Activity Scale for the Elderly (PASE) measure: Physical Performance Battery (SPPB) measure: General Self-Efficacy Scale measure: Positive Affect and Negative Affect Scale (PANAS) sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Drexel Universitsy city: Philadelphia state: Pennsylvania zip: 19102 country: United States lat: 39.95233 lon: -75.16379 hasResults: False
nctId: NCT06334315 id: 2000037337 id: R01HD111436 type: OTHER_GRANT domain: NIH briefTitle: Oral Contraceptive Pill (OCP) Pharmacogenomics overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2028-05 date: 2028-05 date: 2024-03-28 date: 2024-03-28 name: Yale University class: OTHER name: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) briefSummary: The goal of this clinical trial is to evaluate how differences in specific parts of our DNA can influence how our bodies break down the hormones contained within oral contraceptive pills, which could affect how well these birth control pills work to prevent pregnancy. We also interested in exploring how these differences in our DNA can also explain why patients taking the exact same formulation of birth control pill will experience very different side effects. The main questions it aims to answer are:
* A transvaginal ultrasound to measure any ovarian follicles (optional procedure) conditions: Contraception conditions: Pharmacogenomic Drug Interaction studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 700 type: ESTIMATED name: Desogestrel / Ethinyl Estradiol Pill measure: Serum etonogestrel concentration measure: Serum ethinyl estradiol concentration measure: Serum estradiol concentration measure: Serum progesterone concentration measure: Modified Hoogland score measure: Positive and Negative Affect Scheduled measure: Sex hormone binding globulin levels measure: Serum albumin concentration sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: University of Colorado Anschutz Medical Campus city: Aurora state: Colorado zip: 80045 country: United States lat: 39.72943 lon: -104.83192 facility: Yale city: New Haven state: Connecticut zip: 06520 country: United States lat: 41.30815 lon: -72.92816 hasResults: False
nctId: NCT06334302 id: RMC0362-23ctil briefTitle: The Effect of Omega Galil Hazelnut Chocolate Spread "O'Sweet Spread" With 80% Reduced Sucrose on Glucose Response of People With TID overallStatus: RECRUITING date: 2024-03-25 date: 2024-04-25 date: 2024-04-25 date: 2024-03-28 date: 2024-04-12 name: Rabin Medical Center class: OTHER name: Omega 3 Galilee briefSummary: Omega Galil has developed a novel fatty sweetener that allows the use of up to 80% less sugar (particularly sucrose) and yet achieves a natural sweet flavor, using a novel technology of milling the natural sucrose crystals together with oil and thus creating a micro-suspension of sugar in oil or fat. The suspension increases the surface area of the sugar particles and thus a lower quantity of sugar is required in order to reach an enhanced perception of sweetness at the sweet taste receptors in the mouth. Omega Galil provides fatty food products that use up to 80% less sucrose, while tasting as sweet as regular sugar sweetened foods, with no aftertastes of sugar substitutes, and no chemical modifications or additives.
Postprandial glucose (PPG) excursions in Type 1 Diabetes happen mainly due to a delay in subcutaneous insulin absorption and action, but also among other factors, depend on the meal composition. The glycemic index (GI) ranks foods based on acute glycemic response over a 2-h period of 50 g of available carbohydrates (CHO) of a test food compared with the reference standard glucose. Glycemic Load (GL) is a GI-weighted measure of carbohydrate content, which estimates the impact of carbohydrate intake using the GI while taking into account the amount of carbohydrates that are eaten in a serving. Several studies have demonstrated differences in PPG after consumption of low versus high GI meals, with rapid glucose spikes following high GI meals . Helping people with T1D achieve a diet with a lower glycemic load can improve both their quality of life and their diabetes-associated complications.
2. compare the acceptance ("Not sweet enough, just right or too sweet") Labeled Magnitude score of O'Sweet compared to the control spread (Nutella). conditions: Type1diabetes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 30 type: ESTIMATED name: Omega Galil Hazelnut Chocolate Spread "O'Sweet Spread" name: Active Control-Nutella hazelnut cocoa spread measure: Delta postprandial glucose level measure: Incremental area under the curve (iAUC) measure: Peak postprandial glucose level measure: Time in range (TIR) of 70-180 mg/dl measure: Percentage of subjects who reached the desired glucose target measure: The percentage of time spent above 180 mg/dl measure: The percentage of time spent above 250 mg/dl measure: The percentage of time spent above 350 md/dl measure: Labeled Magnitude Scale (gLMS) sex: ALL minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Schneider Children Medical Center of Israel status: RECRUITING city: Petach-Tikva country: Israel name: Alona Hamou, MSc role: CONTACT phone: 972-545-950-277 email: alonah@clalit.org.il lat: 32.08707 lon: 34.88747 hasResults: False
nctId: NCT06334289 id: YXLL-KY-2024(017) briefTitle: A Predictive Study of Peripheral Blood Biomarkers on Postoperative Neurocognitive Dysfunction in Elderly Frail and Non-frail Patients Undergoing Gastrointestinal Surgery overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2024-12-31 date: 2024-03-28 date: 2024-03-28 name: Qianfoshan Hospital class: OTHER briefSummary: Perioperative neurocognitive impairment (PND) mainly includes acute postoperative delirium (POD) and persistent postoperative cognitive impairment (POCD), which are common postoperative complications in elderly patients. Perioperative neurocognitive impairment (PND) is attracting increasing attention, but its exact mechanism is still unclear. The diagnosis of PND lacks the gold standard, so it is difficult to determine the incidence rate. At present, the diagnosis is mainly conducted through the scale. Therefore, this study aims to explore the correlation between peripheral blood biomarkers and PND in elderly frail patients undergoing gastrointestinal surgery. conditions: Perioperative Neurocognitive Disorders conditions: Frail Elderly studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 338 type: ESTIMATED measure: Postoperative 7-day incidence of PND sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT hasResults: False
nctId: NCT06334276 id: DROWN_INHOS briefTitle: Developing an Utstein-style Danish Drowning Registry: Nationwide Fatal and Nonfatal Drowning Data Since 2016 acronym: DROWN_INHOS overallStatus: NOT_YET_RECRUITING date: 2025-01-01 date: 2025-12-31 date: 2025-12-31 date: 2024-03-28 date: 2024-03-28 name: Prehospital Center, Region Zealand class: OTHER briefSummary: This nationwide, registry-based study aims to link Danish Prehospital Drowning Data data with inhospital data to develop a Utstein-style Danish Drowning Registry. This study will report mortality and neurological outcomes 30 days after a drowning incident since 2016. conditions: Drowning conditions: Drowning, Near conditions: Drowning; Asphyxia conditions: Drowning and Nonfatal Submersion conditions: Drowning or Immersion of Unknown Intent conditions: Drowning and Submersion, Undetermined Intent conditions: Drowning and Submersion While in Bath-Tub conditions: Drowning and Submersion While in Natural Water conditions: Drowning and Submersion While in Swimming-Pool studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 1500 type: ESTIMATED name: Drowning measure: 30-day mortality measure: Neurological outcome measure: Hospital length of stay measure: Intensive care unit admission measure: Intensive care unit length of stay measure: Need for mechanical ventilation measure: Duration of mechanical ventilation measure: Survival to hospital discharge sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Prehospital Center city: Næstved state: Region Zealand zip: 4700 country: Denmark lat: 55.22992 lon: 11.76092 hasResults: False
nctId: NCT06334263 id: 332302 briefTitle: Splenic Embolisation Decisions acronym: SPEED overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-09-30 date: 2025-09-30 date: 2024-03-27 date: 2024-03-27 name: University Hospital Plymouth NHS Trust class: OTHER briefSummary: The spleen is often injured when the body sustains trauma. This leads to bleeding. The bleeding can be stopped by a big operation cutting open the belly or a small hole in your groin where a blood vessel can be accessed and through which the bleeding can be stopped. We do not know what types of injuries it is best to use this procedure. We do not know why we do not use the smaller technique in some instances. We also do not know exactly which of a number of ways to stop the bleeding could be better. We have a big data set in the trauma and audit research network (TARN) which we would like to use to help answer these questions and design further studies to better answer the questions. Adding a few other pieces of data, we are able to answer key questions into how the spleen will best be treated in trauma. conditions: Trauma conditions: Spleen Injury studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: OTHER count: 8000 type: ESTIMATED measure: To determine if service design significantly affects splenic embolisation (SE) rates in AAST grade 2-5 acute traumatic splenic injuries (ATSI) across the 22 Major Trauma Centres (MTCs) in the UK. measure: To determine if variation in treatment affects SE outcomes in ATSI sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06334250 id: IRAS:327077 briefTitle: Pulsed Field Ablation During Left Atrial Appendage Occlusion: A Randomised Controlled Trial acronym: PLANET-AF overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2026-12 date: 2024-03-27 date: 2024-03-27 name: Liverpool Heart and Chest Hospital NHS Foundation Trust class: OTHER briefSummary: Atrial fibrillation (AF) is the most common abnormal heart rhythm. It is also a leading cause of stroke, due to blood clots forming within an area called the 'left atrial appendage'. Usually, blood thinners (anticoagulants) are given to patients to reduce this risk. However, some patients are not able to take these medications due to a high bleeding risk. In this situation, these patients are sometimes offered a 'left atrial appendage occlusion' (LAAO) procedure - this is performed by inserting wires through the veins in the groin into the heart, then deploying a device which blocks the appendage, thus stopping blood clots from forming. There is increasing interest within our professional community of combining this procedure with another, called 'catheter ablation', which is performed to improve the symptoms of AF. This procedure uses similar access to the heart, but is not often performed in the same sitting - and often not performed at all in this patient group as they are felt to be at higher risk of complications due to bleeding or clotting. Pulsed Field Ablation (PFA) is a new technology which significantly improves safety of ablation. In this randomised controlled trial, patients referred for LAAO will be randomised to receive LAAO+PFA (intervention) or LAAO alone (control). Patients will be blinded to treatment received, which allows thorough assessment of the benefit of ablation. conditions: Atrial Fibrillation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 66 type: ESTIMATED name: Catheter ablation of atrial fibrillation using Pulsed Field Ablation name: Left atrial appendage occlusion measure: Change in quality of lfie measure: Time to atrial fibrillation recurrence measure: Requirement for unplanned further ablation or cardioversion procedures measure: Procedural metrics measure: Procedural safety outcomes sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Liverpool Heart and Chest Hospital city: Liverpool state: Merseyside zip: L14 3PE country: United Kingdom name: Mark Mills role: CONTACT phone: +441516001616 email: mark.mills@lhch.nhs.uk lat: 53.41058 lon: -2.97794 hasResults: False
nctId: NCT06334237 id: Y_113_0009 briefTitle: Psychosomatic Factors Influencing the Efficacy of Holistic Care for Migraine overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-02-21 date: 2026-02-21 date: 2024-03-27 date: 2024-03-27 name: Changhua Christian Hospital class: OTHER briefSummary: This research project aims at exploring the psychosomatic factors that influence and moderate the efficacy of holistic care and personalized treatment for migraine patients. It is a prospective longitudinal observational study. The project's goal is to understand how physical, psychological, spiritual, and social factors affect the care and treatment outcomes for migraineurs. The study will include participants aged 18 to 65, who meet the International Headache Society's criteria for migraines. It will utilize a range of methodologies including questionnaires, interviews, and medical records to collect data on various factors like lifestyle, psychological state, and social support. The project will assess the effectiveness of treatments, compliance, and other outcomes such as emotional and sleep conditions. conditions: Migraine studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 120 type: ESTIMATED name: personalized treatment measure: Migraine attack frequency measure: Migraine attack intensity measure: Migraine attack duration measure: Effectiveness of acute medication measure: Compliance rate of migraine diary measure: Compliance rate of lifestyle modification measure: depression measure: anxiety measure: well-being measure: Pain Resilience sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Changhua Christian Hospital city: Chang Hua zip: 500 country: Taiwan name: Yen-Yu Chen, MD role: CONTACT phone: +886-4-7238595 email: 107281@cch.org.tw lat: 24.07327 lon: 120.56276 hasResults: False
nctId: NCT06334224 id: 2242/MODREC/23 briefTitle: Acute Physiological Responses to Twice Daily Blood Flow Restriction Training overallStatus: RECRUITING date: 2023-11-06 date: 2024-09 date: 2024-09 date: 2024-03-27 date: 2024-03-27 name: Defence Medical Rehabilitation Centre, UK class: OTHER_GOV name: University of Bath briefSummary: The Academic Department of Military Rehabilitation (ADMR) is currently conducting a pan-defence, randomised control trial (RCT) investigating the utility of twice daily blood flow restriction training in UK military personnel with persistent knee pain (NCT05719922). Due to logistical confinements, this pan-defence RCT is confined to collecting outcome data pre and post-intervention. Therefore, the acute physiological mechanisms which underpin adaptation will remain unknown.
Consequently, ADMR is undertaking an additional, single centre RCT which will compare the acute physiological responses to low load resistance training with and without the addition of blood flow restriction. Specifically, this study will elucidate the effect of twice daily blood flow restriction training on measures of muscle swelling, muscle damage and inflammation. This data may aid in the optimisation of blood flow restriction exercise prescription within UK Defence Rehabilitation and elsewhere. conditions: Muscle Weakness conditions: Muscle Damage studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two arm randomised control trial primaryPurpose: BASIC_SCIENCE masking: NONE maskingDescription: Due to the nature of the intervention, it is not possible to blind participants or outcome assessors to the treatment allocation. There is also no effective sham condition available. This is a common limitation within all blood flow restriction training research. count: 18 type: ESTIMATED name: Low load resistance training with blood flow restriction name: Low load resistance training measure: Maximum isometric voluntary contraction of knee extensor muscles measure: Vastus lateralis muscle thickness measure: Venous blood sampling for markers of exercise induced muscle damage measure: Delayed onset muscle soreness measure: Quadriceps discomfort measure: Discomfort caused by the BFR cuff measure: Rating of perceived exertion measure: Knee joint range of motion measure: Daily wellness questionnaire measure: Venous blood sampling for inflammatory markers sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Defence Medical Rehabilitation Centre status: RECRUITING city: Loughborough zip: LE12 5QW country: United Kingdom name: Kieran M Lunt, MSc role: CONTACT phone: +44(0) 1509 251 500 phoneExt: 3401 email: kieran.lunt103@mod.gov.uk name: Peter Ladlow, PhD role: CONTACT phone: +44(0) 1509 251 500 phoneExt: 3407 email: peter.ladlow100@mod.gov.uk name: Kieran M Lunt, MSc role: PRINCIPAL_INVESTIGATOR lat: 52.76667 lon: -1.2 hasResults: False
nctId: NCT06334198 id: Naldemedine_OIBD id: 2023-507744-36-00 type: CTIS briefTitle: The Effect of Naldemedine on Opioid-induced Bowel Dysfunction overallStatus: RECRUITING date: 2024-03-12 date: 2025-03 date: 2025-03 date: 2024-03-27 date: 2024-03-28 name: Asbjørn Mohr Drewes class: OTHER briefSummary: Opioid-induced bowel dysfunction is a frequent condition during opioid therapy for chronic pain. Indeed, up to 90% of people on opioid treated patients experience constipation. Standard laxative treatment is often ineffective in opioid-induced constipation, but peripheral acting mu-receptor antagonists (PAMORAs) have the potential to block the effects of opioids in the gastrointestinal tract while preserving the central analgesic effect. In this study, we will investigated the effects of Naldemedine in preventing the development of opioid-induced bowel dysfunction and constipation during treatment with tramadol conditions: Opioid-Induced Bowel Dysfunction conditions: Constipation studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 20 type: ESTIMATED name: Naldemedine name: Placebo name: Tramadol measure: Total gastrointestinal transit time measure: Colorectal transit time measure: Constipation symptoms measure: Bowel movement frequency measure: Stool consistency measure: Gastrointestinal symptoms measure: Opioid-induced constipation measure: Diagnostic evaluation of opioid-induced constipation measure: Colonic motility patterns measure: Opiate withdrawal symptoms measure: Colon volume measure: Colonic water content measure: Defecation assessment sex: MALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Aalborg University Hospital status: RECRUITING city: Aalborg zip: 9000 country: Denmark name: Asbjørn Mohr Drewes role: CONTACT lat: 57.048 lon: 9.9187 hasResults: False