nctId: NCT06308328 id: NFEC-2024-090 briefTitle: A Real-world Observational Study of a Mucosal Contouring Method for Radiation-induced Oropharyngeal Mucositis overallStatus: RECRUITING date: 2024-04-01 date: 2026-11-30 date: 2027-01-31 date: 2024-03-13 date: 2024-03-13 name: Nanfang Hospital, Southern Medical University class: OTHER briefSummary: The performance of the predictive models for the occurrence and severity of oropharyngeal mucositis established using either oral cavity contouring method or mucosa surface contouring method was unsatisfactory in nasopharyngeal carcinoma (NPC). Whereas the predictive model of a mucosal contouring method based on swallowing-induced breakthrough pain exhibited better overall performance in locally advanced NPC. Therefore, the investigators aimed to conduct a prospective, multicenter, real-world observational study to further assess the predictive efficacy of this mucosal delineation method for radiation-induced oropharyngeal mucositis in NPC. conditions: Radiation-induced Oropharyngeal Mucositis conditions: Swallowing-induced Breakthrough Pain studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 718 type: ESTIMATED measure: The AUC of the predictive model measure: The accuracy of the predictive model measure: The sensitivity of the predictive model measure: The specificity of the predictive model measure: The positive predictive value of the predictive model measure: The negative predictive value of the predictive model measure: The F1 score of the predictive model measure: The important predictors of severe oropharyngeal mucositis in the predictive model sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Affiliated Cancer Hospital & Institute of Guangzhou Medical University status: NOT_YET_RECRUITING city: Guangzhou state: Guangdong country: China name: Ronghui Zheng role: CONTACT lat: 23.11667 lon: 113.25 facility: Nanfang hospital, Southern medical university status: RECRUITING city: Guangzhou state: Guangdong country: China name: Jian Guan, Ph.D. role: CONTACT phone: 86+13632102247 email: guanjian5461@163.com lat: 23.11667 lon: 113.25 facility: Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University status: NOT_YET_RECRUITING city: Guangzhou state: Guangdong country: China name: Yimin Liu role: CONTACT lat: 23.11667 lon: 113.25 facility: Sun Yat-sen University Cancer Center status: NOT_YET_RECRUITING city: Guangzhou state: Guangdong country: China name: Linglong Tang role: CONTACT lat: 23.11667 lon: 113.25 facility: The First Affiliated Hospital, Sun Yat-sen University status: NOT_YET_RECRUITING city: Guangzhou state: Guangdong country: China name: Yong Bao role: CONTACT lat: 23.11667 lon: 113.25 facility: Yuebei People's Hospital status: NOT_YET_RECRUITING city: Shaoguan state: Guangdong country: China name: Suming Pan role: CONTACT lat: 24.8 lon: 113.58333 facility: Peking University Shenzhen Hospital status: NOT_YET_RECRUITING city: Shenzhen state: Guangdong country: China name: Min Chen role: CONTACT lat: 22.54554 lon: 114.0683 facility: The Fifth Affiliated Hospital, Sun Yat-sen University status: NOT_YET_RECRUITING city: Zhuhai state: Guangdong country: China name: Siyang Wang role: CONTACT lat: 22.27694 lon: 113.56778 facility: Fudan University Shanghai Cancer Center status: NOT_YET_RECRUITING city: Shanghai state: Shanghai country: China name: Xueguan lv role: CONTACT lat: 31.22222 lon: 121.45806 facility: Sichuan Cancer Hospital status: NOT_YET_RECRUITING city: Chendu state: Sichuan country: China name: Wenjun Liao role: CONTACT hasResults: False