hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06302803 id: NFEC-2024-033 briefTitle: Modified Intermittent Eating on Weight Loss (INTEREST-3 Trial) acronym: INTEREST-3 overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-12-31 date: 2027-07-01 date: 2024-03-12 date: 2024-04-02 name: Nanfang Hospital, Southern Medical University class: OTHER briefSummary: Calorie restriction (CR) is the most important treatment for weighting loss. In recent years, two novel types of intermittent fasting recently have gained more attention: the 5:2 diet and time-restricted eating (TRE). TRE requires individuals to eat in a specified number of hours per day (typically 4 to 10 hours) without energy intake restriction. The 5:2 diet involves 5 feast days and 2 fast days per week; participants eat ad libitum without restriction on feast days while 25% of energy needs (approximately 500-800 kcal per day) are consumed on fast days. However, the effects of dietary strategy of intermittent fasting plus time-restricted eating (modified time-restricted eating: TRE 5 days and fasting 2days per week) on weight loss and cardiometabolic risk factors in obese adults have not been proved. This randomized controlled trial aimed to evaluate the effect of modified time-restricted eating (mTRE) and CR on weight loss and cardiometabolic risk factors in obese adults compared to usual health care over 12 months. conditions: Obesity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 225 type: ESTIMATED name: Intermittent fasting plus time-restricted eating name: Calorie restriction measure: Change in body weight over 12 months measure: Change in body mass index （BMI） measure: Change in waist circumference measure: Change in body fat composition meassured by DEXA measure: Change in liver fat measure: Change in systolic blood pressure measure: Change in diastolic blood pressure measure: Change in concentration of serum triglyceride measure: Change in concentration of serum total cholesterol measure: Change in concentration of serum LDL-c measure: Change in concentration of HbA1c measure: Change in insulin sensitivity measure: Change in β cell function measure: Change in arterial stiffness measured by pulse wave velocity measure: Change in depression score measured by the Patient Health Questionnaire-9 measure: Change in quality of sleep score measured by the Pittsburgh sleep quality index measure: Change in quality of life score measured by the 12-item Short-Form Health Survey Questionnaire sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Nanfang Hospital of Southern Medical University city: Guangzhou state: Guangdong zip: 510515 country: China lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06302790 id: AcuteMolliiSuitEffects briefTitle: Examination of the Acute Effect of Mollii Suit in Children With Cerebral Palsy overallStatus: RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-05-01 date: 2024-03-12 date: 2024-03-12 name: Kırıkkale University class: OTHER name: Gazi University briefSummary: The aim of our study is to examine the acute effect of Mollii Suit application on balance and muscle tone problems in children with spastic cerebral palsy. conditions: Mollii Suit conditions: Cerebral Palsy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: The statistician in the study and the physiotherapist performing the evaluation will be blinded. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Molli Suit Apply measure: Gross Motor Function Classification System (GMFCS) measure: Modified Tardiue Scale (MTS) measure: Modifiye Modified Ashworth Scale (MAS) measure: NMC Tests with Seansamove Sensbalance sex: ALL minimumAge: 4 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Gazi University status: RECRUITING city: Ankara country: Turkey name: Kübra Uğurlu role: CONTACT phone: +905077295353 email: kubra.ozdamar06@gmail.com lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06302777 id: 2023-1184 briefTitle: MAIN-IMAGE Registry acronym: MAIN-IMAGE overallStatus: RECRUITING date: 2023-09-26 date: 2028-09-26 date: 2031-09-26 date: 2024-03-12 date: 2024-03-12 name: Goethe University class: OTHER briefSummary: All comers registry with patients with chronic coronary syndrome or acute coronary syndrome who underwent intracoronary imaging during cardiac catherization. The aim is to identify plaque characteristics on OCT or IVUS that are associated with adverse cardiac events including myocardial infarction and atherosclerotic progression. conditions: Coronary Artery Disease studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 500 type: ESTIMATED measure: Major adverse cardiovascular Events (MACE) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Frankfurt University Hospital status: RECRUITING city: Frankfurt state: Hesse zip: 60590 country: Germany name: Lena Seegers role: CONTACT phone: +496963016666 lat: 50.11552 lon: 8.68417 facility: Frankfurt University Hospital status: RECRUITING city: Frankfurt country: Germany name: Lena Seegers role: CONTACT lat: 50.11552 lon: 8.68417 hasResults: False
nctId: NCT06302764 id: WZiKS.4.1.2023.2 id: WZiKS.4.1.2023 type: OTHER_GRANT domain: Jagiellonian University in Kraków briefTitle: Emergency Medical Staff Workload Analysis overallStatus: RECRUITING date: 2023-10-01 date: 2024-04-20 date: 2024-06-30 date: 2024-03-12 date: 2024-04-16 name: Jagiellonian University class: OTHER briefSummary: The aim of this study is to identify trauma determinants and leverage this understanding to develop solutions applicable to the prevention and treatment of PTSD among emergency medical personnel. By categorizing stimuli associated with traumatic professional experiences, the study aims to enhance existing therapeutic protocols through exposure therapy. The specific objectives are as follows:
5. Formation of an interdisciplinary international research team. conditions: Stress conditions: Work Related Stress conditions: PTSD conditions: Mental Stress conditions: Medical Emergencies studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 400 type: ESTIMATED name: Qualitative & Quantitative Research measure: Focused Interview measure: Posttraumatic Stress Disorder Checklist (PCL-5) measure: Patient Health Questionnaire (PHQ-9) measure: Depersonalization Mechanism Scale (DMS) sex: ALL minimumAge: 21 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Institute of Applied Psychology, Jagiellonian University in Krakow, Poland status: RECRUITING city: Krakow state: Małopolska zip: 30-348 country: Poland name: Krystyna Golonka, Prof role: CONTACT email: krystyna.golonka@uj.edu.pl name: Katarzyna Sitnik-Warchulska, PhD role: CONTACT email: katarzyna.sitnik-warchulska@uj.edu.pl name: Krystyna Golonka, Prof role: PRINCIPAL_INVESTIGATOR name: Katarzyna Sitnik-Warchulska, PhD role: SUB_INVESTIGATOR name: Dominika Fortuna, MS role: SUB_INVESTIGATOR lat: 50.06143 lon: 19.93658 facility: University of Coimbra status: RECRUITING city: Coimbra country: Portugal name: João Ferreira, PhD role: CONTACT email: naquelepordosol@gmail.com name: João Ferreira, PhD role: SUB_INVESTIGATOR lat: 40.20564 lon: -8.41955 facility: Bogomolets National Medical University status: RECRUITING city: Kyiv country: Ukraine name: Sergii Tukaiev, PhD role: CONTACT email: tsv.serg.69@gmail.com name: Borys Palamar, Prof role: CONTACT email: palamar.bi@ukr.net name: Borys Palamar, Prof role: SUB_INVESTIGATOR name: Sergii Tukaiev, PhD role: PRINCIPAL_INVESTIGATOR lat: 50.45466 lon: 30.5238 hasResults: False
nctId: NCT06302751 id: 3647 briefTitle: A Mobile Application to Improve Postoperative Outcomes in Colorectal Cancer acronym: RAISe-Care overallStatus: RECRUITING date: 2024-02-26 date: 2026-02-26 date: 2026-08-31 date: 2024-03-12 date: 2024-03-15 name: Istituto Clinico Humanitas class: OTHER briefSummary: The unplanned readmission rate after colorectal cancer surgery is still high, despite the implementation of enhanced recovery programs. The use of a mobile-based application for perioperative remote monitoring may improve the postoperative outcomes and reduce the unplanned postoperative readmissions. conditions: Colorectal Cancer conditions: Surgery studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Single-center, prospective, interventional case-series study with a historical cohort of comparison primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 600 type: ESTIMATED name: Care 4 Today ® (Johnson and Johnson) mobile app measure: Unplanned hospital readmissions measure: Severity of postoperative complications measure: Length of hospital stay measure: Time from symptoms onset to diagnosis measure: Healthcare costs sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Humanitas Research Hospital status: RECRUITING city: Rozzano state: MI zip: 20089 country: Italy name: Annalisa Maroli, PhD role: CONTACT phone: 02 8224 7776 phoneExt: 0039 email: colorapp@humanitas.it name: Stefano De Zanet, MS role: CONTACT phone: 02 8224 4623 phoneExt: 0039 email: colorapp@humanitas.it lat: 45.38193 lon: 9.1559 hasResults: False
nctId: NCT06302738 id: 09C221 briefTitle: Phenotypisation of Sleep Pattern in Hypertensive Patients With Non Dipper Pattern acronym: INTO-DIP overallStatus: RECRUITING date: 2023-05-04 date: 2024-12-31 date: 2024-12-31 date: 2024-03-12 date: 2024-04-16 name: Istituto Auxologico Italiano class: OTHER briefSummary: High blood pressure is the most common modifiable risk factor for cardiovascular diseases (CV). The large interindividual variability in clinical expression of the disease and response to treatment, however, makes the management of the hypertensive patient complex.Therefore, identifying phenotypes of hypertensive patients associated with a specific CV outcome or who tend to respond/not respond to treatment is of paramount importance for improving CV prevention.
The non-dipper profile and nocturnal hypertension are caused by several factors including excessive salt intake and dysautonomia. However, they are also inevitably influenced by sleep duration and the presence of sleep disorders: obstructive sleep apnea (OSA), but also insomnia and periodic movements of the lower limbs,such as those frequently seen in restless legs syndrome, are among the the main determinants related to altered nighttime pressure pattern. However, such disturbances are not systematically assessed during the performance of monitoring 24h pressor and their impact in the outcome of the hypertensive patient is unknown.
nctId: NCT06302712 id: TIIP briefTitle: Traditional Islamically Integrated Psychotherapy for Muslims With OCD in Pakistan overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-10-01 date: 2024-11-30 date: 2024-03-12 date: 2024-03-18 name: International Islamic University Malaysia class: OTHER name: Foundation University Islamabad briefSummary: The current study aims to determine the effectiveness of the first culturally adapted Traditional Islamically Integrated Psychotherapy (TIIP) for Muslims with OCD in Pakistan along with the module effectiveness in reducing OCD symptoms with comorbidities like anxiety, depression, stress, thought control, thought-action fusion, and enhancing the spiritual quality of life of participants. conditions: Obsessive-Compulsive Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: Traditional Islamically Integrated Psychotherapy measure: Yale Brown Obsessive Compulsive Scale measure: Depression, Stress, Anxiety measure: Thought Action Fusion measure: Thought Control measure: Spiritual Quality sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT hasResults: False
nctId: NCT06302699 id: UCAD-MM-001 briefTitle: Detecting Minimal Residual Diseases (MRD) and Monitoring Clonal Evolution Using Ultrasensitive Chromosomal Aberrations Detection (UCAD) in Multiple Myeloma overallStatus: RECRUITING date: 2023-05-01 date: 2024-05-01 date: 2026-03-01 date: 2024-03-12 date: 2024-03-12 name: Institute of Hematology & Blood Diseases Hospital, China class: OTHER briefSummary: The presence of minimal residual disease (MRD) is an important prognostic factor for multiple myeloma, while copy number variation (CNV) is a widely accepted biomarker used for multiple myeloma (MM). Detecting MRD and monitoring clonal evolution by monitoring CNV using low-pass whole genome sequencing is promising due to its high analytical sensitivity. To evaluate the correlation between MRD detected by flow cytometry and low-pass whole genome sequencing, nearly 200 samples were collected for this study. We applied ultrasensitive chromosomal aberrations detection to detect CNV for each patient. The follow-up samples were then collected and sequencing used the same method. conditions: Multiple Myeloma studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 80 type: ESTIMATED measure: Detection of copy number variation measure: Serial monitoring of treatment response sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06302686 id: INRCA_004_2023 briefTitle: engAGE: Managing cognitivE decliNe throuGh Theatre Therapy, Artificial Intelligence and Social Robots drivEn Interventions acronym: engAGE overallStatus: RECRUITING date: 2023-10-09 date: 2024-06-24 date: 2024-06-24 date: 2024-03-12 date: 2024-03-12 name: Istituto Nazionale di Ricovero e Cura per Anziani class: OTHER name: European Union briefSummary: The objectives of the engAGE project are to counteract and slow down cognitive decline progression, to enhance the intrinsic capacity of the users, and to support the wellbeing of older persons with mild cognitive impairment (MCI) by providing an ecosystem of services based on an innovative system that integrates social robots. conditions: Mild Cognitive Impairment conditions: Older Adults studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 78 type: ESTIMATED name: engAGE system name: Group practicing with only the support of a booklet measure: Change in perceived stability of cognitive status by the older adults measure: Change in cognitive impairment in older adults measure: Change in depression in older adults measure: Change in frailty status in older adults measure: Change in mental well being in older adults measure: Change in quality of life in older adults measure: Change in acceptability of the engAGE system in older adults measure: Change in quality of life in informal caregivers measure: Change in mental well being in informal caregivers measure: Change in caregiver burden sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: IRCCS INRCA Hospital status: RECRUITING city: Ancona zip: 60127 country: Italy name: Elvira Maranesi role: CONTACT name: Roberta Bevilacqua role: PRINCIPAL_INVESTIGATOR lat: 43.5942 lon: 13.50337 facility: Karde A/S status: RECRUITING city: Oslo country: Norway name: Terje Grimstad role: CONTACT name: Terje Grimstad role: PRINCIPAL_INVESTIGATOR lat: 59.91273 lon: 10.74609 facility: HUG status: RECRUITING city: Geneva country: Switzerland name: Christian Lovis role: CONTACT name: Christian Lovis role: PRINCIPAL_INVESTIGATOR lat: 46.20222 lon: 6.14569 hasResults: False
nctId: NCT06302673 id: 23081229 briefTitle: The Role Of Laserpuncture For Prevention Of Nausea And Vomiting Post Strabismus Surgery With General Anesthesia In Adult Patients overallStatus: RECRUITING date: 2023-10-09 date: 2024-10 date: 2024-10 date: 2024-03-12 date: 2024-03-12 name: Indonesia University class: OTHER briefSummary: This study to determine the effectiveness of a combination of pre-surgical laserpuncture with standard anti-emetic therapy for PONV symptoms in adult patients after strabismus surgery under general anesthesia compared to a combination of pre-surgical placebo laserpuncture with standard anti-emetic therapy. Research design using a double blinded randomized controlled trial (RCT) where research subjects and data takers who will be disguised. The research will be carried out in the Operation and Inpatient Room, Kirana Building, RSUPN Dr. Cipto Mangunkusumo (RSCM) with research subjects as adult patients undergoing strabismus surgery under general anesthesia. Assessment of nausea and vomiting using AVS ( Analog Visual Scale) consists of scoring using a score from 1-5 which indicates the severity of nausea and vomiting. conditions: Nausea and Vomiting, Postoperative studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Double blinded randomized controlled trial (RCT) primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 32 type: ESTIMATED name: Laserpuncture and anti emetic standar therapy name: Sham Laserpuncture and anti emetic standar therapy measure: Analog Visual Scale for nausea vomitting sex: ALL minimumAge: 18 Years maximumAge: 59 Years stdAges: ADULT facility: RSUPN Dr. Cipto Mangunkusumo status: RECRUITING city: Jakarta Pusat state: Jakarta country: Indonesia name: Yossie Faudina Putri, MD role: CONTACT phone: 6281290371481 email: yossie.dina2@gmail.com lat: -6.1818 lon: 106.8223 hasResults: False
nctId: NCT06302660 id: 22/LO/0169 briefTitle: Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors acronym: MAPLES overallStatus: RECRUITING date: 2022-03-09 date: 2024-06-01 date: 2025-06-01 date: 2024-03-12 date: 2024-04-18 name: Imperial College London class: OTHER name: Imperial College Healthcare NHS Trust name: West Hertfordshire Teaching Hospitals NHS Trust name: Barking, Havering and Redbridge University Hospitals NHS Trust briefSummary: The goal of this observational study is to learn about long term symptoms in oesophageal cancer survivors. The main question it aims to answer is are:
Researchers will compare symptomatic and asymptomatic participants to detect the changes stated above. conditions: Oesophageal Cancer conditions: Quality of Life conditions: Bacterial Overgrowth studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 100 type: ESTIMATED name: Breath test name: Saliva sample name: Blood sample name: Urine sample name: Stool sample name: Health-related Quality of life questionnaires measure: Identify microbiome dysbiosis in saliva associated with long-term functional symptoms. measure: Identify microbiome dysbiosis in stool associated with long-term functional symptoms. measure: Identify underlying metabolic pathways associated with microbiome derived metabolites. measure: Develop a breath test to detect volatile biomarkers associated with microbiome dysbiosis. measure: Propose a strategy for treatment of long-term symptoms in oesophageal adenocarcinoma survivors. sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Barking, Havering and Redbridge University Hospitals NHS Trust status: RECRUITING city: London country: United Kingdom name: Munir Tarazi, MB BCh BAO MRCS MCh role: CONTACT phone: +44 (0)20 7594 8197 email: m.tarazi@imperial.ac.uk lat: 51.50853 lon: -0.12574 facility: Imperial College Healthcare NHS Trust status: RECRUITING city: London country: United Kingdom name: Munir Tarazi, MB BCh BAO MRCS MCh role: CONTACT phone: +44 (0)20 7594 8197 email: m.tarazi@imperial.ac.uk lat: 51.50853 lon: -0.12574 facility: West Hertfordshire NHS Teaching Hospitals status: RECRUITING city: London country: United Kingdom name: Munir Tarazi, MB BCh BAO MRCS MCh role: CONTACT phone: +44 (0)20 7594 8197 email: m.tarazi@imperial.ac.uk lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06302647 id: PI-6022 briefTitle: Assessing Interest in Web/App Platforms for Early Phase Clinical Trial Recruitment overallStatus: NOT_YET_RECRUITING date: 2024-03-14 date: 2024-06-15 date: 2024-06-30 date: 2024-03-12 date: 2024-03-15 name: Instituto de Investigación Hospital Universitario La Paz class: OTHER briefSummary: Study objective:
Keywords: healthy volunteer, patient, pharma industry, patient associaiton, questionnaire, clinical trial, platform, recruitment, engagement. conditions: Assessing Interest in a Platform for Early Phase Clinical Trial Recruitment studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Questionnaires measure: percentage of each of the three groups that would find the platform useful sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06302621 id: 21-725 briefTitle: Pemigatinib + Afatinib in Advanced Refractory Solid Tumors overallStatus: RECRUITING date: 2024-07-01 date: 2024-12-01 date: 2025-12-01 date: 2024-03-12 date: 2024-04-26 name: Massachusetts General Hospital class: OTHER name: Boehringer Ingelheim name: Incyte Corporation briefSummary: This study is researching whether the combination of Afatinib and Pemigatinib is safe and effective in FGFR altered unresectable or metastatic advanced solid tumors.
This research study involves the study drugs Afatinib and Pemigatinib. conditions: Advanced Solid Tumor conditions: Unresectable Solid Tumor conditions: Metastatic Solid Tumor conditions: Cholangiocarcinoma studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 70 type: ESTIMATED name: Afatinib name: Pemigatinib measure: Maximum tolerated dose (MTD) measure: Objective response rate (ORR) measure: Disease Control Rate measure: Duration of Response measure: Overall Survival measure: Progression-free Survival measure: Best Overall Response measure: Time to response measure: Treatment Related Adverse Events measure: Maximum Plasma Concentration [Cmax]) and C trough of pemigatinib and afatinib measure: Molecular correlates of response sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Massachusetts General Hospital status: RECRUITING city: Boston state: Massachusetts zip: 02115 country: United States name: Andreas Varkaris, MD role: CONTACT phone: 617-724-4000 email: AVARKARIS@MGH.HARVARD.EDU name: Andreas Varkaris, MD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06302608 id: NGGT-BCD-P-2203 briefTitle: Safety and Efficacy Study of NGGT001 in Bietti Crystalline Corneoretinal Dystrophy overallStatus: ACTIVE_NOT_RECRUITING date: 2023-02-08 date: 2024-05-29 date: 2028-05-29 date: 2024-03-12 date: 2024-03-12 name: Xiamen Ophthalmology Center Affiliated to Xiamen University class: OTHER briefSummary: Evaluate the safety and tolerability of NGGT001 subretinal injection for the treatment of crystalline retinal degeneration (BCD) conditions: Bietti's Crystalline Dystrophy studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 6 type: ESTIMATED name: NGGT001 measure: BCVA measure: Incidence and severity of adverse events (AEs) and serious adverse events (SAEs) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Xiuju Chen city: Xiamen state: Fujian zip: 361000 country: China lat: 24.47979 lon: 118.08187 hasResults: False