BV is a type of drug called an antibody-drug conjugate (ADC). ADCs are a substance made up of a monoclonal antibody chemically linked to a drug. Antibodies are proteins made by the immune system to fight infections and other possible harms to the body. The monoclonal antibody binds to specific proteins or receptors found on certain types of cells, including cancer cells. The linked drug enters these cells and kills them without harming other cells. Researchers think BV may be an effective treatment for this type of cancer because the drug targets cells that have CD30, which play a role in cancer cell growth. By destroying these cells, BV may help slow or stop the growth of the cancer. AVD (doxorubicin, vinblastine, and dacarbazine) is a treatment regimen that works by stopping the growth of cancer cells, either by killing the cells or by stopping them from dividing. The researchers think that BV in combination with AVD may work better than AVD alone to slow or stop the growth of the cancer. conditions: Hodgkin Lymphoma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This is a multicenter, investigator-initiated, single-arm phase II trial. primaryPurpose: TREATMENT masking: NONE count: 71 type: ESTIMATED name: Brentuximab vedotin name: Doxorubicin name: Vinblastine name: Dacarbazine name: Pembrolizumab name: Gemcitabine name: Vinorelbine name: FDG-PET/CT scan measure: progression-free survival measure: overall survival sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Miami status: NOT_YET_RECRUITING city: Miami state: Florida zip: 33136 country: United States name: Craig Moskowitz, MD role: CONTACT phone: 305-243-5302 lat: 25.77427 lon: -80.19366 facility: Memorial Sloan Kettering Basking Ridge (All Protocol Activities) status: RECRUITING city: Basking Ridge state: New Jersey zip: 07920 country: United States name: Robert Stuver, MD role: CONTACT phone: 646-608-4308 lat: 40.70621 lon: -74.54932 facility: Memorial Sloan Kettering Monmouth (All Protocol Activities) status: RECRUITING city: Middletown state: New Jersey zip: 07748 country: United States name: Robert Stuver, MD role: CONTACT phone: 646-608-4308 lat: 40.39652 lon: -74.09211 facility: Memorial Sloan Kettering Bergen (All Protocol Activities) status: RECRUITING city: Montvale state: New Jersey zip: 07645 country: United States name: Robert Stuver, MD role: CONTACT phone: 646-608-4308 lat: 41.04676 lon: -74.02292 facility: Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities) status: RECRUITING city: Commack state: New York zip: 11725 country: United States name: Robert Stuver, MD role: CONTACT phone: 646-608-4308 lat: 40.84288 lon: -73.29289 facility: Memorial Sloan Kettering Westchester (All Protocol Activities) status: RECRUITING city: Harrison state: New York zip: 10604 country: United States name: Robert Stuver, MD role: CONTACT phone: 646-608-4308 lat: 40.96899 lon: -73.71263 facility: Memorial Sloan Kettering Cancer Center (All Protocol Activities) status: RECRUITING city: New York state: New York zip: 10065 country: United States name: Robert Stuver, MD role: CONTACT phone: 646-608-4308 lat: 40.71427 lon: -74.00597 facility: Memorial Sloan Kettering Nassau (All Protocol Activities) status: RECRUITING city: Uniondale state: New York zip: 11553 country: United States name: Robert Stuver, MD role: CONTACT phone: 646-608-4308 lat: 40.70038 lon: -73.59291 hasResults: False