The primary purpose of this study is to search for a potential correlation between dosimetry and physician- and patient-rated symptoms in patients treated with exclusive radiotherapy for head and neck cancer. conditions: Head and Neck Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 180 type: ESTIMATED name: Exclusive radiotherapy measure: Evaluation of nausea (acute toxicity) using CTCAE V5.0 measure: Evaluation of nausea (acute toxicity) using M.D. Anderson Symptom Inventory (MDASI-SCORE) questionnaire measure: Identification of the organs at risk most strongly correlated with the onset of nausea measure: Identification of dosimetric cutoffs for the onset of nausea measure: Comparison of dosimetric analysis between 3D conformal, IMRT and proton therapy techniques measure: Development of machine-learning predictive models for the onset of nausea sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona status: RECRUITING city: Ancona country: Italy name: Giovanna Mantello role: CONTACT email: clelia.dicarlo@ospedaliriuniti.marche.it lat: 43.5942 lon: 13.50337 facility: Ospedale "Mons. Dimiccoli" status: RECRUITING city: Barletta country: Italy name: Alessia Di Rito role: CONTACT email: aledirito@yahoo.it lat: 41.31429 lon: 16.28165 facility: Azienda Ospedaliera S.Pio status: RECRUITING city: Benevento country: Italy name: Angela Argenone role: CONTACT email: angela.argenone@ao-rummo.it lat: 41.1307 lon: 14.77816 facility: Ospedale MultiMedica status: RECRUITING city: Castellanza country: Italy name: Gianpiero Catalano role: CONTACT email: gianpiero.catalano@multimedica.it lat: 45.61079 lon: 8.89616 facility: IRCCS Ospedale Policlinico San Martino status: RECRUITING city: Genova country: Italy name: Liliana Belgioia role: CONTACT email: liliana.belgioia@unige.it lat: 44.40478 lon: 8.94438 facility: European Institute of Oncology status: RECRUITING city: Milan country: Italy name: Stefania Volpe role: CONTACT lat: 45.46427 lon: 9.18951 facility: IRCCS Ospedale San Raffaele status: RECRUITING city: Milan country: Italy name: Italo Dell'Oca role: CONTACT email: delloca.italo@hsr.it lat: 45.46427 lon: 9.18951 facility: Azienda Ospedaliero-Universitaria di Modena status: RECRUITING city: Modena country: Italy name: Elisa D'Angelo role: CONTACT email: dangelo.elisa@policlinico.mo.it lat: 44.64783 lon: 10.92539 facility: Azienda Ospedaliero Universitaria Ospedale Maggiore della Carità di Novara status: RECRUITING city: Novara country: Italy name: Carla Pisani role: CONTACT email: carla.pisani@maggioreosp.novara.it lat: 45.44694 lon: 8.62118 facility: Fondazione IRCCS Policlinico San Matteo status: RECRUITING city: Pavia country: Italy name: Sara Colombo role: CONTACT email: s.colombo@smatteo.pv.it lat: 45.19205 lon: 9.15917 facility: Azienda Ospedaliera Complesso Ospedaliero San Giovanni - Addolorata status: RECRUITING city: Roma country: Italy name: Giuseppina Apicella role: CONTACT email: gapicella@hsangiovanni.roma.it lat: 41.89193 lon: 12.51133 facility: Azienda Ospedaliero Universitaria Policlinico Umberto I status: RECRUITING city: Roma country: Italy name: Francesca De Felice role: CONTACT email: francesca.defelice@uniroma1.it lat: 41.89193 lon: 12.51133 facility: Ospedale San Giovanni Calibita Fatebenefratelli Isola Tiberina status: RECRUITING city: Roma country: Italy name: Orietta Caspiani role: CONTACT email: o.caspiani@gmail.com lat: 41.89193 lon: 12.51133 facility: I.R.C.C.S. MultiMedica - Sesto San Giovanni status: RECRUITING city: Sesto San Giovanni country: Italy name: Gianpiero Catalano role: CONTACT email: gianpiero.catalano@multimedica.it lat: 45.53329 lon: 9.22585 hasResults: False