hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06307041 id: OSATAGUN briefTitle: Effects of 0.2% Hyaluronic Acid Gel-Impregnated Dental Flosses on Clinical Gingival Parameters overallStatus: COMPLETED date: 2023-04-03 date: 2023-07-07 date: 2023-08-11 date: 2024-03-12 date: 2024-03-12 name: Özlem SARAÇ ATAGÜN class: OTHER briefSummary: This study aimed to evaluate the effects of 0.2% HA-impregnated dental flosses on the clinical periodontal parameters of patients with gingivitis. conditions: Gingivitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: single-center, single-blinded, split-mouth, randomized clinical trial primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: The investigator who performed the measurements was blinded to which side of patients was the test group whoMasked: INVESTIGATOR count: 30 type: ACTUAL name: Dental floss+Gengigel name: Dental Floss measure: Clinical Periodontal Parameter-Gingival Index (GI) measure: Clinical Periodontal Parameter-Papillary Bleeding Index (PBI) measure: Clinical Periodontal Parameter-Plaque Index(PI) sex: ALL minimumAge: 18 Years maximumAge: 47 Years stdAges: ADULT facility: Sağlık Bilimleri Üniversitesi Gülhane Diş Hekimliği Fakültesi city: Ankara zip: 06010 country: Turkey lat: 39.91987 lon: 32.85427 hasResults: False
nctId: NCT06307028 id: Pro2023002116 id: K01DA050496 type: NIH link: https://reporter.nih.gov/quickSearch/K01DA050496 briefTitle: Sistas Informing Sistas on Topics About AIDS and Prevention (SISTA-P) acronym: SISTA-P overallStatus: RECRUITING date: 2024-01-08 date: 2024-07-01 date: 2024-08-31 date: 2024-03-12 date: 2024-03-12 name: Rutgers, The State University of New Jersey class: OTHER name: National Institutes of Health (NIH) name: National Institute on Drug Abuse (NIDA) briefSummary: In this project, the investigators will provide a new HIV prevention training and empowerment sessions to Black women in Washington D.C. who are at high risk for getting HIV. This training is tailored to the experience of Black women and seeks to reduce the high HIV transmission rates in the Black community. conditions: Health Behavior, Risky conditions: Health Knowledge, Attitudes, Practice conditions: Health-Related Behavior studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 30 type: ESTIMATED name: SISTA-P Intervention measure: Feasibility of the Intervention Scale measure: Acceptability of the Intervention Scale measure: Appropriateness of the Intervention Scale measure: Recruitment measure: Intervention Fidelity- participant characteristics measure: Intervention Fidelity measure: Acceptability of the intervention delivery measure: Participant Enrollment measure: Participant Retention measure: Feasibility of delivering 6 sessions in 6 weeks measure: Visual confirmation of self-reported PrEP uptake measure: Post-Intervention Follow-up sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Women's Collective status: ACTIVE_NOT_RECRUITING city: Washington state: District of Columbia zip: 20002 country: United States lat: 38.89511 lon: -77.03637 facility: Rutgers University status: RECRUITING city: New Brunswick state: New Jersey zip: 08854 country: United States name: Shawnika Hull, PhD role: CONTACT phone: 520-661-3300 email: shawnika.hull@rutgers.edu name: Shawnika Hull, PhD role: PRINCIPAL_INVESTIGATOR lat: 40.48622 lon: -74.45182 hasResults: False
nctId: NCT06307015 id: 2023/ETH02441 briefTitle: De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE) acronym: DE-RADIATE overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-12 date: 2031-12 date: 2024-03-12 date: 2024-03-12 name: Royal North Shore Hospital class: OTHER briefSummary: The goal of this prospective clinical trial is to determine if HPV-associated oropharyngeal squamous cell carcinoma that is non-hypoxic on FMISO PET can be successfully treated with a lower dose of radiation therapy.
Patients with cT1-2N1-2b (AJCC 7th edition) oropharyngeal tumours will undergo surgical resection of the primary tumour. Following this, they will be allocated to standard radiation therapy (70Gy with concurrent cisplatin chemotherapy) or de-escalation radiation therapy (30Gy with concurrent cisplatin chemotherapy) based on the results of FMISO PET. Patients with non-hypoxic tumours at baseline OR after two weeks of radiation therapy will be allocated to the de-escalated group. 3-4 months after completion of radiation therapy, all patients in the de-escalated group will undergo mandatory neck dissection to assess pathologic response.
Researchers will assess the pathologic response rate after surgery in the de-escalation group. They will also compare the outcomes (oncological outcomes and quality of life) between the group receiving the standard treatment (70Gy) and the group receiving de-escalated radiation therapy (30Gy). conditions: HPV Positive Oropharyngeal Squamous Cell Carcinoma studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 25 type: ESTIMATED name: De-escalation name: Standard of care measure: Pathologic complete response measure: Correlation between MRI and FMISO PET assessment of hypoxia measure: Quality of Life of patients undergoing de-escalation radiation therapy measure: Quality of Life of patients undergoing de-escalation radiation therapy measure: Local control measure: Regional control measure: Distant metastases measure: Acute toxicities measure: Late toxicities sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Northern Sydney Cancer Centre, Royal North Shore Hospital city: Saint Leonards state: New South Wales zip: 2065 country: Australia name: Carol Kwong role: CONTACT phone: 9463 1300 email: carolyn.kwong@health.nsw.gov.au name: Anna Lawless role: PRINCIPAL_INVESTIGATOR name: Sarah Bergamin role: PRINCIPAL_INVESTIGATOR lat: -33.82344 lon: 151.19836 hasResults: False
nctId: NCT06307002 id: CAS_EB_2024 briefTitle: Evaluating What's My Method? in Barbados overallStatus: RECRUITING date: 2024-03-11 date: 2024-06-15 date: 2024-07-30 date: 2024-03-12 date: 2024-03-15 name: Quinnipiac University class: OTHER name: Barbados Family Planning Association briefSummary: The purpose of this study is to measure the impact of the What's My Method game on participants' sense of agency, education, and empowerment around contraceptive decision-making. Patients receiving standard of care contraceptive counseling will be compared to those who play the game in addition to counseling. conditions: Contraception Behavior studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a 2 arm randomized controlled trial comparing standard of care (SOC) counseling alone to What's My Method? (WMM) gameplay in addition to SOC. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 70 type: ESTIMATED name: Playing a contraception education videogame measure: Contraceptive Self-Efficacy (CSE) score measure: Method Adoption measure: Qualitative feedback on game intervention sex: FEMALE minimumAge: 18 Years maximumAge: 48 Years stdAges: ADULT facility: Barbados Family Planning Association status: RECRUITING city: Bridgetown state: Saint Michaels zip: BB11085 country: Barbados name: Anderson Langdon, MA role: CONTACT phone: 2462336750 email: anderson@bfpaonline.com name: Tiffany Jordan, MD role: CONTACT phone: 2468324827 email: tiffany@bfpaonline.com name: Tiffany Jordan, MD role: SUB_INVESTIGATOR lat: 13.10731 lon: -59.62021 hasResults: False
nctId: NCT06306989 id: Zhengzhou University briefTitle: Observational Clinical Study of Letermovir for Preventing CMV Infection After Allo-HSCT overallStatus: RECRUITING date: 2023-01-01 date: 2024-09-01 date: 2025-12-01 date: 2024-03-12 date: 2024-03-12 name: Cao Weijie class: OTHER briefSummary: The goal of this observational study is to get a series of clinical data related to the prevention of CMV infection after allo-HSCT with letemovir. The main question it aims to answer are:
* Optimal initiation of letemovir to prevent CMV infection. Participants will be categorized into high-risk and intermediate-risk groups based on risk factors for CMV infection.Initiate letemovir prophylaxis on day +1 in high-risk patients and on days +7 to +14 in non-high-risk patients.(240 mg, qd in patients with concomitant cyclosporine; 480 mg, qd in patients with concomitant tacrolimus) to +100 days. For patients with comorbid GVHD who require intensive immunosuppression, consider extending the regimen to +200 days.Treatments they will be given and use bullets. conditions: Letemovir for the Prevention of CMV Infection After Allo-HSCT studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 150 type: ESTIMATED name: Letermovir measure: Prevalence of CMV viremia and CMV disease within 100 days after allogeneic hematopoietic stem cell transplantation. measure: +30-day CMV viremia, CMV disease; +30-day overall survival, non-relapse mortality; +30-day relapse rate; +30-day aGVHD incidence. measure: +100-day overall survival, non-relapse mortality; + 100-day relapse rate; + 100-day aGVHD incidence. measure: +180-day CMV viremia, CMV disease; +30-day overall survival, non-relapse mortality; +180-day relapse rate; +180-day aGVHD incidence. sex: ALL minimumAge: 14 Years maximumAge: 100 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Cao, Weijie status: RECRUITING city: Zhengzhou state: Henan zip: 450000 country: China name: Weijie W Cao, doctor of medicine role: CONTACT phone: +8618937390269 email: 2549509184@qq.com name: Mengyang M Zhu, Postgraduate medical students role: CONTACT phone: +8615093360671 phoneExt: 0371-66913114 email: Caoweijie2003@126.com lat: 34.75778 lon: 113.64861 hasResults: False
nctId: NCT06306976 id: 2066031 briefTitle: Shear-Wave Elastography acronym: ELASTOGRAPHY overallStatus: ENROLLING_BY_INVITATION date: 2024-03 date: 2024-07 date: 2025-08 date: 2024-03-12 date: 2024-03-13 name: Prisma Health-Upstate class: OTHER briefSummary: Prospective cohort study of patients with midline ventral incisional hernia with a range of hernia morphology who plan to undergo open retromuscular VHR.
Control groups: The study plans to enlist 5 volunteers with no incisional hernia or prior laparotomy to establish internal baseline SWE values and interrater reliability. The study will also plan to recruit 5 patients undergoing primary laparotomy in order to correlate SWE findings with closure tension. conditions: Ventral Incisional Hernia studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescription: Specific Aim 1:
Correlate SWE-determined elasticity of abdominal wall to intraoperative assessment of tension required to achieve fascial closure. primaryPurpose: OTHER masking: NONE count: 70 type: ESTIMATED name: Elective Midline Laparotomy name: Imaging: Ultrasound name: Tensiometry measure: Determine Elasticity of Abdominal Wall Muscles (Specific Aim 1) measure: Correlate Elastography measurements with MFR (Specific Aim 2) measure: Correlate SWE Assessment to Tensiometer (Specific Aim 3) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Prisma Health city: Greenville state: South Carolina zip: 29615 country: United States lat: 34.85262 lon: -82.39401 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2023-06-01 uploadDate: 2024-03-11T16:32 filename: Prot_000.pdf size: 301771 typeAbbrev: SAP hasProtocol: False hasSap: True hasIcf: False label: Statistical Analysis Plan date: 2023-07-12 uploadDate: 2024-03-11T16:33 filename: SAP_001.pdf size: 170975 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-07-12 uploadDate: 2024-03-11T16:33 filename: ICF_002.pdf size: 179351 hasResults: False
nctId: NCT06306963 id: 23-004669 briefTitle: Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias acronym: GAVE overallStatus: RECRUITING date: 2024-03-22 date: 2026-03-01 date: 2026-09-01 date: 2024-03-12 date: 2024-04-26 name: Mayo Clinic class: OTHER briefSummary: The researchers are trying to find out more about Gastric Antral Vascular Ectasia (GAVE). This is a condition that affects the blood vessels in the stomach, leading to their enlargement and possible bleeding. It can also cause symptoms such as abdominal pain and nausea. By participating in this study, you will help us learn how often these symptoms occur and how they relate to stomach functioning. conditions: Gastric Antral Vascular Ectasia conditions: Cirrhosis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 30 type: ESTIMATED name: Gastric Emptying measure: Abridged Bowel Disease Questionnaire measure: Nepean Dyspepsia Index measure: Leuven Postprandial Distress Scale measure: Gastric Emptying Half Time (T 1/2) of Solids measure: Gastric Emptying Half Time (T 1/2) of liquids sex: ALL minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mayo Clinic status: RECRUITING city: Rochester state: Minnesota zip: 55905 country: United States name: Taylor N Hines role: CONTACT phone: 507-538-9959 email: hines.taylor@mayo.edu name: Anjali Rajagopal, MBBS role: CONTACT phone: 507-266-8779 email: Rajagopal.Anjali@mayo.edu name: Xiao Jing Wang, MD role: PRINCIPAL_INVESTIGATOR lat: 44.02163 lon: -92.4699 hasResults: False
nctId: NCT06306950 id: PMK-00098 briefTitle: Prioritization of Cerebral Deoxygenation in Severe Traumatic Brain Injury and Mortality Benefit. overallStatus: COMPLETED date: 2021-04-01 date: 2024-02-28 date: 2024-02-28 date: 2024-03-12 date: 2024-03-15 name: Phramongkutklao College of Medicine and Hospital class: OTHER briefSummary: Severe traumatic brain injury with a decrease in cerebral oximetry is associated with multiple impaired systemic microcirculations, more morbidities, and a higher mortality rate. When using the brain as an index organ, interventions to improve brain oxygen delivery may have systemic benefits for these patients. conditions: Cerebral Hypoxia conditions: Severe Traumatic Brain Injury studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: In a prospective study, 80 patients were randomized to either application of near-infrared reflectance spectroscopy (NIRS) monitoring with active display or attempt to make an intervention to keep regional cortical cerebral oxygen saturation (rSO2) ≥ 55% by increased cardiac output, mean arterial pressure, and adjusting the ventilator to hypoventilation (PaCO2 40-45 mmHg) (exclude in radiographic brain herniation) (intervention, n = 40), compared with usual care (n = 40). Clinical outcomes were assessed by a blind observer. Data collection comprised of patients' demographic data, intervention process, and outcomes of treatment assessed by modified Rankin scale (mRS) followed up at 1 year. primaryPurpose: PREVENTION masking: TRIPLE maskingDescription: Upon arrival in the emergency department, the randomization envelope was opened, and patients were assigned into either active treatment (intervention) or usual care (control) groups with cerebral oximetry monitoring using NIRS bilaterally (Root; Prime Medical Corporation, MASIMO, USA). whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 80 type: ACTUAL name: Near infrared spectroscopy neuromonitor to prevent cerebral desaturation measure: modified Rankin scale (mRS) followed up at 1 year sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Phramongkutklao College of Medicine and Hospital city: Bangkok zip: 10400 country: Thailand lat: 13.75398 lon: 100.50144 hasResults: False
nctId: NCT06306937 id: A24020822 briefTitle: Serum Levels of Vitamin D and IL8 in Patients With Periodontitis overallStatus: COMPLETED date: 2022-09-01 date: 2023-09-30 date: 2023-09-30 date: 2024-03-12 date: 2024-03-12 name: Mansoura University class: OTHER briefSummary: We evaluated vitamin D and IL8 levels in the serum of patients with periodontitis as well as the healthy controls to correlate their levels with the degree of periodontitis. conditions: Periodontal Diseases studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 98 type: ACTUAL name: Evalution of serum levels of vitamin D and IL8 measure: Serum Levels of 25(OH)vitamin D measure: Serum Levels of IL8 measure: Plaque Index (Pl) measure: Clinical Attachment Loss (CAL) measure: Probing Pocket Depth (PPD) sex: ALL minimumAge: 21 Years maximumAge: 55 Years stdAges: ADULT facility: Mansoura University, Faculty of Dentistry city: Mansoura state: Dakahlia zip: 35516 country: Egypt lat: 31.03637 lon: 31.38069 hasResults: False
nctId: NCT06306924 id: LCCC2303 briefTitle: UNC Metastatic Cancer Radiation Therapy Registry overallStatus: RECRUITING date: 2024-04-21 date: 2033-05 date: 2033-05 date: 2024-03-12 date: 2024-04-26 name: UNC Lineberger Comprehensive Cancer Center class: OTHER briefSummary: The purpose of this registry is to collect clinical data from participants attending UNC Hospitals who present with metastatic cancer and are evaluated to receive radiation therapy as part of their standard of care treatment. The goal of this study is to provide a foundation for studies designed to identify projects across the translational continuum related to metastatic cancer and radiation therapy treatment. The relevant clinical data will be linked to patient-reported outcomes (PROs) thus allowing for a unique and robust dataset. Ultimately, this registry will provide current and future studies with the ability to analyze the correlation of radiation therapy regimens with metastatic cancer outcomes. conditions: Cancer conditions: Metastatic Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2000 type: ESTIMATED name: Radiation therapy measure: Clinical Data measure: Patient reported outcomes (PRO) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill status: RECRUITING city: Chapel Hill state: North Carolina zip: 27599 country: United States name: Shivani Sud, MS role: CONTACT phone: 919-918-5924 email: sshivani.sud@unchealth.unc.edu name: Shivani Sud, MD role: PRINCIPAL_INVESTIGATOR lat: 35.9132 lon: -79.05584 hasResults: False
nctId: NCT06306911 id: BB-BAM briefTitle: Bioavailability of Aronia Melanocarpa overallStatus: RECRUITING date: 2024-03 date: 2024-07 date: 2024-07 date: 2024-03-12 date: 2024-03-12 name: Maastricht University Medical Center class: OTHER name: BioActor briefSummary: The main objective of this study is to study the bioavailability and kinetics of acute Aronia Melanocarpa supplementation in healthy young (18-35 years) and older adults (55-75 years) adults. During the test day, participants will ingest a drink consisting of Aronia Melanocarpa extract (AME). The bioavailability and kinetics of AME will be assessed via frequent blood sampling, urine collection, and faecal sampling, in which AME and metabolite profiles will be quantified. conditions: Bioavailability conditions: Kinetics studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 16 type: ESTIMATED name: Aronia Melanocarpa extract measure: Aronia metabolites in blood measure: Aronia metabolites in urine measure: Aronia metabolites in feces measure: length - baseline characteristics measure: weight - baseline characteristics measure: blood pressure (systolic and diastolic) - baseline characteristics sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Maastricht University status: RECRUITING city: Maastricht country: Netherlands name: Sanne Ahles, Msc role: CONTACT email: s.ahles@maastrichtuniversity.nl name: Jogchum Plat, Prof role: CONTACT lat: 50.84833 lon: 5.68889 hasResults: False
nctId: NCT06306898 id: IAV-2024-01 briefTitle: Intra-Arrest-Ventilation in Human Cadavers overallStatus: NOT_YET_RECRUITING date: 2024-03-18 date: 2024-10-31 date: 2024-12-31 date: 2024-03-12 date: 2024-03-19 name: Gerrit Jansen class: OTHER name: Ruhr University of Bochum name: Bielefeld University briefSummary: The study investigates the influence of non-synchronized bag-device-ventilation and intermittent positive pressure ventilation (IPPV), as recommended in the current resuscitation guidelines of the European Resuscitation Concil (tidal Volume (Vt) = 5-6 mL/kg body weight, respiratory rate = 10 min-1) and Chest Compression Synchronized Ventilation (pInsp = 40 mbar; respiratory rate = chest compression rate) with regard to achieving a sufficient tidal volume and the tightness of various supraglottic airway devices (laryngeal mask, i-Gel-laryngeal mask, laryngeal tube) and endotracheal intubation. conditions: Cardiac Arrest studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Randomized crossover design primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: Endotracheal Intubation name: Laryngeal tube name: Laryngeal mask name: I-Gel-Laryngeal Mask measure: Expiratory Volume with different Airway Devices in IPPV measure: Ventilation Pressure with different Airway devices in CCSV sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06306885 id: CLF23/03 briefTitle: Effects of Early Sleep After Action Observation and Motor Imagery After Metacarpal Fracture Surgery overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-09-01 date: 2025-05-01 date: 2024-03-12 date: 2024-03-12 name: Istituto Clinico Humanitas class: OTHER briefSummary: The study aimed to investigate the effects of early sleep after action observation and motor imagery (AOMI) training sessions on manual dexterity in patients with hand immobilization after surgical fixation for metacarpals and phalanges fractures.
Fifty-one patients with hand immobilization for surgical fixation of IV or V metacarpals or first phalanges fractures will be randomized into AOMI-sleep (n=17), AOMI-control (n=17), and Control (n=17) group. AOMI-sleep and AOMI-control groups will perform an AOMI-training before sleeping or in the morning respectively, while Control group will be asked to observe landscape video-clips. Participants will be assessed for manual dexterity, hand range of motion, hand disability and quality of life at baseline before and after the training and at 1 month after the training end. conditions: Hand Injuries conditions: Action Observation conditions: Motor Imagery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 51 type: ESTIMATED name: Action observation plus motor imagery followed by sleep name: Action observation plus motor imagery name: Control measure: Changes in Purdue Pegboard Test measure: Changes in kinematic indexes during Nine Hole Peg Test measure: Changes in Visual Analogue Scale measure: Changes in Quick-DASH measure: Changes in EQ5D measure: Changes in Total Active Motion measure: Hand-grip strength sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT hasResults: False