The sub study investigating the impact of discontinuing and continuing hypertonic saline is registered under NCTXXXXXXX (will add once available). conditions: Cystic Fibrosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 477 type: ACTUAL name: Discontinuation of dornase alfa (Dnase) name: Continuation of dornase alfa (Dnase) measure: Absolute Change in FEV1 % Predicted From Week 0 to Week 6 measure: Absolute Change in LCI 2.5 From Baseline to Week 6 measure: Absolute Change in Respiratory Symptoms, as Measured by the CF Respiratory Symptoms Diary-Chronic Respiratory Infection Symptom Severity Score (CRISS) From Week 0 to Week 6 measure: Absolute Change in Respiratory Symptoms, as Measured by CFQ-R Respiratory Domain From Week 0 to Week 6 measure: Absolute Change in FEV1 % Predicted From Week -2 to Week 0 measure: Absolute Change in FEV1 % Predicted From Week 0 to Week 2 measure: Number and Percent of Participants Initiating Acute Antibiotics From Week 0 to Week 6 measure: Number and Percent of Participants Hospitalized From Week 0 to Week 6 measure: Number and percent of participants Experiencing Pulmonary Exacerbations from Week 0 to Week 6 measure: Number and Percent of Participants Experiencing Adverse Events (AEs) From Week 0 to Week 6 measure: Rate of Adverse Events (AEs) From Week 0 to Week 6 Therapy Arms measure: Number and Percent of Participants with Temporary or Permanent Changes From Assigned Therapy Regimen Due to Adverse Event From Week 0 to Week 6 sex: ALL minimumAge: 12 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: University of Alabama at Birmingham city: Birmingham state: Alabama zip: 35294 country: United States lat: 33.52066 lon: -86.80249 facility: Providence Alaska Medical Center city: Anchorage state: Alaska zip: 99508 country: United States lat: 61.21806 lon: -149.90028 facility: Tucson Cystic Fibrosis Center city: Tucson state: Arizona zip: 85724 country: United States lat: 32.22174 lon: -110.92648 facility: Arkansas Children's Hospital city: Little Rock state: Arkansas zip: 72202 country: United States lat: 34.74648 lon: -92.28959 facility: Miller Children's and Women's Hospital Long Beach city: Long Beach state: California zip: 90806 country: United States lat: 33.76696 lon: -118.18923 facility: CHOC Children's Hospital city: Orange state: California zip: 92868 country: United States lat: 33.78779 lon: -117.85311 facility: Stanford University Medical Center city: Palo Alto state: California zip: 94304 country: United States lat: 37.44188 lon: -122.14302 facility: Rady Children's Hospital and Health Center at the University of California San Diego city: San Diego state: California zip: 92123 country: United States lat: 32.71533 lon: -117.15726 facility: University of California, San Francisco - Adult Center city: San Francisco state: California zip: 94143 country: United States lat: 37.77493 lon: -122.41942 facility: University of California, San Francisco - Peds Center city: San Francisco state: California zip: 94158 country: United States lat: 37.77493 lon: -122.41942 facility: Children's Hospital Colorado city: Aurora state: Colorado zip: 80045 country: United States lat: 39.72943 lon: -104.83192 facility: National Jewish Health city: Denver state: Colorado zip: 80206 country: United States lat: 39.73915 lon: -104.9847 facility: Yale University School of Medicine city: New Haven state: Connecticut zip: 06520 country: United States lat: 41.30815 lon: -72.92816 facility: University of Florida city: Gainesville state: Florida zip: 32610 country: United States lat: 29.65163 lon: -82.32483 facility: Nemours Children's Clinic - Jacksonville city: Jacksonville state: Florida zip: 32207 country: United States lat: 30.33218 lon: -81.65565 facility: Central Florida Pulmonary Group city: Orlando state: Florida zip: 32803 country: United States lat: 28.53834 lon: -81.37924 facility: The Nemours Children's Clinic - Orlando city: Orlando state: Florida zip: 32827 country: United States lat: 28.53834 lon: -81.37924 facility: Nemours Children's Clinic - Pensacola city: Pensacola state: Florida zip: 32514 country: United States lat: 30.42131 lon: -87.21691 facility: All Children's Hospital city: Saint Petersburg state: Florida zip: 33701 country: United States lat: 27.77086 lon: -82.67927 facility: Tampa General Hospital city: Tampa state: Florida zip: 33606 country: United States lat: 27.94752 lon: -82.45843 facility: Emory University city: Atlanta state: Georgia zip: 30324 country: United States lat: 33.749 lon: -84.38798 facility: Saint Luke's Cystic Fibrosis Center of Idaho city: Boise state: Idaho zip: 83702 country: United States lat: 43.6135 lon: -116.20345 facility: Northwestern University city: Chicago state: Illinois zip: 60611 country: United States lat: 41.85003 lon: -87.65005 facility: OSF Saint Francis Medical Center city: Peoria state: Illinois zip: 61637 country: United States lat: 40.69365 lon: -89.58899 facility: Riley Hospital for Children city: Indianapolis state: Indiana zip: 46202 country: United States lat: 39.76838 lon: -86.15804 facility: University of Iowa city: Iowa City state: Iowa zip: 52242 country: United States lat: 41.66113 lon: -91.53017 facility: University of Kansas Medical Center city: Kansas City state: Kansas zip: 66160 country: United States lat: 39.11417 lon: -94.62746 facility: University of Kentucky city: Lexington state: Kentucky zip: 40506 country: United States lat: 37.98869 lon: -84.47772 facility: University of Louisville city: Louisville state: Kentucky zip: 40202 country: United States lat: 38.25424 lon: -85.75941 facility: Tulane University city: Metairie state: Louisiana zip: 70001 country: United States lat: 29.98409 lon: -90.15285 facility: Maine Medical Partners Pediatric Specialty Care city: Portland state: Maine zip: 04102 country: United States lat: 43.66147 lon: -70.25533 facility: John Hopkins Hospital city: Baltimore state: Maryland zip: 21205 country: United States lat: 39.29038 lon: -76.61219 facility: Boston Children's Hospital city: Boston state: Massachusetts zip: 02115 country: United States lat: 42.35843 lon: -71.05977 facility: University of Michigan, Michigan Medicine city: Ann Arbor state: Michigan zip: 48109 country: United States lat: 42.27756 lon: -83.74088 facility: Wayne State University Harper University Hospital city: Detroit state: Michigan zip: 48201 country: United States lat: 42.33143 lon: -83.04575 facility: Corewell Health Helen DeVos city: Grand Rapids state: Michigan zip: 49546 country: United States lat: 42.96336 lon: -85.66809 facility: Children's Hospitals and Clinics of Minnesota city: Minneapolis state: Minnesota zip: 55404 country: United States lat: 44.97997 lon: -93.26384 facility: The Minnesota Cystic Fibrosis Center city: Minneapolis state: Minnesota zip: 55455 country: United States lat: 44.97997 lon: -93.26384 facility: Children's Mercy Kansas City city: Kansas City state: Missouri zip: 64108 country: United States lat: 39.09973 lon: -94.57857 facility: Washington University School of Medicine city: Saint Louis state: Missouri zip: 63110 country: United States lat: 38.62727 lon: -90.19789 facility: Billings Clinic city: Billings state: Montana zip: 59101 country: United States lat: 45.78329 lon: -108.50069 facility: Dartmouth Hitchcock Medical Center city: Lebanon state: New Hampshire zip: 03756 country: United States lat: 43.64229 lon: -72.25176 facility: Monmouth Medical Center city: Eatontown state: New Jersey zip: 07724 country: United States lat: 40.29622 lon: -74.05097 facility: Morristown Medical Center city: Morristown state: New Jersey zip: 07960 country: United States lat: 40.79677 lon: -74.48154 facility: Rutgers - Robert Wood Johnson Medical School city: New Brunswick state: New Jersey zip: 08903 country: United States lat: 40.48622 lon: -74.45182 facility: Cohen Children's Medical Center of New York city: New Hyde Park state: New York zip: 11042 country: United States lat: 40.7351 lon: -73.68791 facility: Beth Israel Medical Center city: New York state: New York zip: 10003 country: United States lat: 40.71427 lon: -74.00597 facility: Lenox Hill Hospital Cystic Fibrosis Center city: New York state: New York zip: 10028 country: United States lat: 40.71427 lon: -74.00597 facility: Columbia University Cystic Fibrosis Program city: New York state: New York zip: 10032 country: United States lat: 40.71427 lon: -74.00597 facility: University of Rochester Medical Center Strong Memorial city: Rochester state: New York zip: 14642 country: United States lat: 43.15478 lon: -77.61556 facility: SUNY Upstate Medical University city: Syracuse state: New York zip: 13210 country: United States lat: 43.04812 lon: -76.14742 facility: New York Medical College at Westchester Medical Center city: Valhalla state: New York zip: 10595 country: United States lat: 41.07482 lon: -73.77513 facility: University of North Carolina at Chapel Hill city: Chapel Hill state: North Carolina zip: 27517 country: United States lat: 35.9132 lon: -79.05584 facility: Atrium Health Wake Forest Baptist city: Winston-Salem state: North Carolina zip: 27157 country: United States lat: 36.09986 lon: -80.24422 facility: Children's Hospital Medical Center of Akron city: Akron state: Ohio zip: 44308 country: United States lat: 41.08144 lon: -81.51901 facility: Cincinnati Children's Hospital Medical Center city: Cincinnati state: Ohio zip: 45229 country: United States lat: 39.12713 lon: -84.51435 facility: Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center city: Cleveland state: Ohio zip: 44146 country: United States lat: 41.4995 lon: -81.69541 facility: Cleveland Clinic Cystic Fibrosis Program city: Cleveland state: Ohio zip: 44195 country: United States lat: 41.4995 lon: -81.69541 facility: Nationwide Children's Hospital city: Columbus state: Ohio zip: 43205 country: United States lat: 39.96118 lon: -82.99879 facility: Dayton Children's Hospital city: Dayton state: Ohio zip: 45404 country: United States lat: 39.75895 lon: -84.19161 facility: Oregon Health & Sciences University city: Portland state: Oregon zip: 97239 country: United States lat: 45.52345 lon: -122.67621 facility: Hershey Medical Center Pennsylvania State University city: Hershey state: Pennsylvania zip: 17033 country: United States lat: 40.28592 lon: -76.65025 facility: University of Pennsylvania city: Philadelphia state: Pennsylvania zip: 19104 country: United States lat: 39.95233 lon: -75.16379 facility: University of Pittsburgh Medical Center city: Pittsburgh state: Pennsylvania zip: 15224 country: United States lat: 40.44062 lon: -79.99589 facility: Medical University of South Carolina city: Charleston state: South Carolina zip: 29425 country: United States lat: 32.77657 lon: -79.93092 facility: Dell Children's Medical Center of Central Texas city: Austin state: Texas zip: 78723 country: United States lat: 30.26715 lon: -97.74306 facility: University of Texas Southwestern / Children's Health city: Dallas state: Texas zip: 75207 country: United States lat: 32.78306 lon: -96.80667 facility: University of Texas Southwestern city: Dallas state: Texas zip: 75390 country: United States lat: 32.78306 lon: -96.80667 facility: Cook Children's Medical Center city: Fort Worth state: Texas zip: 76104 country: United States lat: 32.72541 lon: -97.32085 facility: University of Texas Health Center at Tyler city: Tyler state: Texas zip: 75708 country: United States lat: 32.35126 lon: -95.30106 facility: Primary Children's Cystic Fibrosis Center city: Salt Lake City state: Utah zip: 84113 country: United States lat: 40.76078 lon: -111.89105 facility: University of Vermont Medical Center city: Burlington state: Vermont zip: 05401 country: United States lat: 44.47588 lon: -73.21207 facility: University of Virginia city: Charlottesville state: Virginia zip: 22904 country: United States lat: 38.02931 lon: -78.47668 facility: Virginia Commonwealth University city: Richmond state: Virginia zip: 23219 country: United States lat: 37.55376 lon: -77.46026 facility: Seattle Children's Hospital city: Seattle state: Washington zip: 98105 country: United States lat: 47.60621 lon: -122.33207 facility: University of Washington Medical Center city: Seattle state: Washington zip: 98195 country: United States lat: 47.60621 lon: -122.33207 facility: Providence Medical Group, Cystic Fibrosis Center city: Spokane state: Washington zip: 99204 country: United States lat: 47.65966 lon: -117.42908 facility: West Virginia University - Morgantown city: Morgantown state: West Virginia zip: 26506 country: United States lat: 39.62953 lon: -79.9559 facility: University of Wisconsin city: Madison state: Wisconsin zip: 53792 country: United States lat: 43.07305 lon: -89.40123 facility: Children's Wisconsin city: Milwaukee state: Wisconsin zip: 53226 country: United States lat: 43.0389 lon: -87.90647 facility: Froedtert & Medical College of Wisconsin city: Milwaukee state: Wisconsin zip: 53226 country: United States lat: 43.0389 lon: -87.90647 hasResults: False