hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06376916 id: IRB00110863 briefTitle: Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR acronym: ATRIUM overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-12 date: 2026-12 date: 2024-04-22 date: 2024-04-24 name: Aurora Health Care class: OTHER briefSummary: The purpose of this prospective, randomized, double-blinded study is to further evaluate the safety and efficacy of varying doses of intravenous magnesium in the treatment of AFF RVR. conditions: Tachycardia Atrial conditions: Atrial Fibrillation conditions: Atrial Flutter With Rapid Ventricular Response studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 153 type: ESTIMATED name: Magnesium Sulfate 2 G name: Magnesium Sulfate 4 G name: Saline measure: Ventricular rate control measure: Time to achieve goal HR (heart rate) measure: Rate of conversion measure: Incidence of hypotension measure: Change in heart rate measure: Clinical need for rescue medication administration measure: Adverse effects sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Advocate Christ Medical Center Emergency Department (ACMC ED) city: Oak Lawn state: Illinois zip: 60453 country: United States name: Marc McDowell, PharmD role: CONTACT phone: 708-684-6230 email: marc.mcdowell@aah.org lat: 41.71087 lon: -87.75811 hasResults: False
nctId: NCT06376903 id: P.T.REC/012/004860 briefTitle: Effect of Pilates Exercises on Stress Urinary Incontinence in Posmenopausal Women overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2024-08-20 date: 2024-09-20 date: 2024-04-22 date: 2024-04-22 name: Cairo University class: OTHER briefSummary: • This study will be conducted to determine the effect of pilates exercises on stress urinary incontinence in postmenopausal women conditions: Urinary Stress Incontinence studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: Pilates exercise - pelvic floor exercise - home advices measure: • Revised urinary incontinence scale measure: • Quality of Life Questionnaire (QOL) for stress urinary incontinence sex: FEMALE minimumAge: 50 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
nctId: NCT06376877 id: 2024P000900 briefTitle: Connectomic Targeted TMS Target for Refractory Anxiety acronym: ConTRA overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2028-08-01 date: 2029-02-01 date: 2024-04-19 date: 2024-04-19 name: Brigham and Women's Hospital class: OTHER briefSummary: We will perform a randomized sham-controlled trial of aiTBS to an anxiosomatic circuit in patients with anxiety-related disorders (i.e., panic disorder, generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder). 80 participants with an anxiety-related disorder (defined below) will receive 50 active or sham TMS treatments over 5 days (following the SAINT protocol, which is FDA-cleared for MDD. The primary outcome will be the BAI, with a modified recall window to reflect the short treatment interval. Participants randomized to sham will be offered an open-label crossover extension. conditions: Anxiety Disorders conditions: Mental Disorder conditions: Psychiatric Disorder studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Nonresponders may have the option for open label active treatment. primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Transcranial magnetic stimulation name: Sham transcranial magnetic stimulation measure: Beck Anxiety Inventory (BAI) measure: Inventory of Depression and Anxiety Symptoms-II measure: Hierarchical Taxonomy of Psychopathology (HiTOP)-Self Report, Distress, Fear, and Mania subfactors measure: State-Trait Anxiety Inventory measure: Penn State Worry Questionnaire (PSWQ) measure: Mood/Anxiety Symptoms Questionnaire: Anxious Arousal (MASQ:AA) measure: Anxiety Sensitivity Index (ASI) measure: Intolerance of Uncertainty Scale (IUS) measure: Beck Depression Inventory (BDI) measure: TCI-R140 (Temperament and character inventory, revised 140-question format) measure: Emotional Conflict Resolution Task measure: Laboratory Fear Extinction Paradigm sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Emma Jones city: Boston state: Massachusetts zip: 02115 country: United States name: Emma Jones role: CONTACT email: bwhtmsanxiety@mgb.org lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06376864 id: RC- FNRA-IG /20-21/SOSC/01 briefTitle: Physical Activity Intervention Effects on Executive Function, Physical Activity and Sedentary Behaviour in Children overallStatus: ACTIVE_NOT_RECRUITING date: 2023-01-01 date: 2024-06-30 date: 2024-07-30 date: 2024-04-19 date: 2024-04-19 name: Hong Kong Baptist University class: OTHER briefSummary: The current study aims to implement the Activity Breaks intervention and evaluate its effectiveness on outcome measures of executive function (EF), physical activity (PA), and sedentary behaviour (SB) in school children. conditions: Child Behavior studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 450 type: ACTUAL name: Activity Breaks measure: Executive function measure: Psychological capacities measure: Working memory measure: Attention measure: Physical activity (min/week) measure: Sedentary behavior (hour) measure: Body weight (kg) measure: Height (cm) sex: ALL minimumAge: 8 Years maximumAge: 12 Years stdAges: CHILD facility: Department of Sport, Physical Education, and Health, Hong Kong Bapist University city: Kowloon Tong country: Hong Kong lat: 22.33312 lon: 114.17969 hasResults: False
nctId: NCT06376851 id: CP-910-001 briefTitle: AI DErived Plaque Quantification: CCTA and AI-QCPA for Determining Effective CAD Management acronym: DECIDE overallStatus: ENROLLING_BY_INVITATION date: 2024-03-27 date: 2026-03-27 date: 2030-03-27 date: 2024-04-19 date: 2024-04-19 name: HeartFlow, Inc. class: INDUSTRY briefSummary: The objective of HeartFlow's DECIDE Registry is to collect observational data about the management of patients before and after HeartFlow Artificial Intelligence-Quantitative Coronary Plaque Analysis (AI-QCPA). conditions: Coronary Artery Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 10000 type: ESTIMATED name: AI-enabled quantitative coronary plaque analysis (AI-QCPA) measure: Primary Endpoint measure: Change in LDL levels measure: Change in HbA1c levels measure: Changes in Non HDL levels measure: Changes in HDL levels measure: Changes in TG levels measure: Changes in weight measure: Reclassification rate of medical management (across the groups) measure: Rates of referral to invasive coronary angiography and coronary revascularization (PCI+CABG) measure: Number of CV hospitalizations measure: Number of MACE (CV-related death, MI, or CAD hospitalization) measure: Timing of referral to other provider(s) for management measure: Timing of lab orders (Group 1 vs. Group 2) measure: Change in Lp(a) (Group 2) measure: Change in Lp(a) (Group 4 compared to Group 1) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Moses Cone Memorial Hospital city: Greensboro state: North Carolina zip: 27401 country: United States lat: 36.07264 lon: -79.79198 hasResults: False
nctId: NCT06376838 id: DLV-001-02 briefTitle: To Prove the Non-inferiority of DLMR01 by Evaluating the Injecting Efficacy and Safety DLMR01 and Control for Patients in Crow's Feet acronym: dermal filler overallStatus: COMPLETED date: 2020-07-07 date: 2021-10-15 date: 2023-05-04 date: 2024-04-19 date: 2024-04-19 name: DEXLEVO class: INDUSTRY briefSummary: This clinical study is a confirmatory clinical study to prove that the test device, DLMR01, is non-inferior to the control device, Rejuran®, in terms of temporary wrinkle improvement effect on crow's feet and safety. After applying DLMR01, a test device, and Rejuran®, a control device, respectively to wrinkles around the eyes, randomization to compare and evaluate the temporary wrinkle improvement effect and safety of the two clinical study medical devices, subject-evaluator blinding, pair matching, It was designed as a comparative clinical study. conditions: Crow's Feet Lines studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 218 type: ACTUAL name: DLMR01 name: Rejuran measure: Crow's Feet Grading Scale by independent evaluators after 12 weeks of using measure: (1) The improvement rate of wrinkles evaluated using the Crow's Feet Grading Scale measure: (2) The improvement rate of wrinkles assessed using the Crow's Feet Grading Scale by independent evaluators after 2 weeks and 4 weeks of using the medical device both during rest and when smiling was evaluated. sex: ALL minimumAge: 19 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Chung-ang University Hospital city: Seoul state: Dongjak-gu zip: 06973 country: Korea, Republic of lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06376825 id: CSV202401 briefTitle: The Efficacy and Acceptability of an Internet-Based Self-Help Program to Reduce Burnout overallStatus: RECRUITING date: 2024-04-15 date: 2024-06-15 date: 2024-06-15 date: 2024-04-19 date: 2024-04-19 name: Ahmet Nalbant class: OTHER briefSummary: The goal of this clinical trial is to determine whether an internet-based self-help program reduces burnout in teachers. The study will also evaluate the program's acceptability which means assessing the extent to which users complete the program and find it useful. The main questions it aims to answer are:
* How much of the program do teachers finish? conditions: Burnout, Professional studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: The study will be a concurrent multiple-baseline single-case experimental study with participiants randomized to baseline durations. primaryPurpose: TREATMENT masking: NONE maskingDescription: In this study participants will be randomized to different baseline durations and randomization will be done by one of the investigators who are blind to participants assessments. count: 25 type: ESTIMATED name: MyLife: An internet-based self-help program to reduce burnout measure: Burnout Assessment Tool measure: Valued Living Questionnaire measure: Acceptance and Action Questionnaire-2 measure: System Usability Scale measure: Attendance rate measure: Daily measures sex: ALL minimumAge: 22 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CanSagligi Foundation Center for Contextual Behavioral Science status: RECRUITING city: Istanbul country: Turkey name: Eda Aksoy role: CONTACT phone: +90(216) 269 66 11 email: eda.aksoy@cansagligivakfi.org name: Ahmet Nalbant, MD role: PRINCIPAL_INVESTIGATOR name: Havvanur Uysal Akdemir, MS role: SUB_INVESTIGATOR name: Edanur Gürbüz, BA role: SUB_INVESTIGATOR name: Meryem Gökçe Yavuz, BA role: SUB_INVESTIGATOR name: Kaasım Fatih Yavuz, MD role: SUB_INVESTIGATOR lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06376812 id: 23-0320 briefTitle: No Time to Pause: Physical Activity to Improve Health of Midlife Hispanic Women overallStatus: NOT_YET_RECRUITING date: 2026-05 date: 2029-01 date: 2029-01 date: 2024-04-19 date: 2024-04-19 name: The University of Texas Medical Branch, Galveston class: OTHER briefSummary: This study will test the effects of a physical activity intervention among midlife Hispanic women. conditions: Elevated Blood Pressure conditions: Perimenopause studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 40 type: ESTIMATED name: Physical activity intervention measure: Days the activity monitor was worn measure: Physical activity as measured by minutes of moderate-vigorous intensity physical activity at 6 months measure: Physical activity as measured by minutes of moderate-vigorous intensity physical activity at 6 months measure: Physical activity as measured by minutes of moderate intensity physical activity at 6 months measure: Physical activity as measured by minutes of moderate intensity physical activity at 6 months measure: Physical activity as measured by minutes of vigorous intensity physical activity at 6 months measure: Physical activity as measured by minutes of vigorous intensity physical activity at 6 months measure: Physical activity as measured by minutes of light intensity physical activity at 6 months measure: Physical activity as measured by minutes of light intensity physical activity at 6 months measure: Physical activity as measured by minutes of total physical activity at 6 months measure: Physical activity as measured by minutes of total physical activity at 6 months measure: Systolic blood pressure measure: Systolic blood pressure measure: Diastolic blood pressure measure: Diastolic blood pressure measure: Abdominal circumference measure: Abdominal circumference measure: Body mass index measure: Body mass index sex: FEMALE minimumAge: 45 Years maximumAge: 50 Years stdAges: ADULT hasResults: False
nctId: NCT06376799 id: 38RC23.0437 id: 2024-A00485-42 type: OTHER domain: ID RCB briefTitle: Which Health-care Professional(s) to Talk About Advance Care Planning ? acronym: QPSPAS overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-11-01 date: 2024-11-02 date: 2024-04-19 date: 2024-04-19 name: University Hospital, Grenoble class: OTHER briefSummary: The goal of this descriptive observational study is to evaluate the preference of French adult patients followed in the context of a oncological disease, regarding the choice of the preferred healthcare professional to discuss advance care planning.
To this end, voluntary participants will be asked to indicate their preferences by answering a self-questionnaire available in electronic or paper format. conditions: Advance Care Planning conditions: Patient Preference studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 240 type: ESTIMATED name: Self-questionnaire measure: Determining the healthcare professional preferred by cancer patients to talk about advance care planning measure: Determining cancer patients' second choice of healthcare professional to talk about advance care planning measure: Evaluation of patient preferences regarding advance care planning, concerning the form, the moment it should be carried out, whether or not they wish to be accompanied by a relative, and the benefit of systematization sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06376786 id: ItaliTTP briefTitle: Italian iTTP Registry overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2030-05-31 date: 2030-05-31 date: 2024-04-19 date: 2024-04-19 name: Fondazione Luigi Villa class: OTHER briefSummary: ItaliTTP is an observational, prospective, single-arm, national, multicenter, non-pharmacological cohort study aimed at better defining and understanding the natural history, disease severity, and clinical outcomes of patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP) in Italy.
A minimum of 132 consecutive patients with acute iTTP (first event or relapse) will be enrolled for 3 years, with the possibility of extension, with a follow-up period of 3 years. conditions: TTP - Thrombotic Thrombocytopenic Purpura studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 132 type: ESTIMATED measure: Age at onset measure: Sex measure: Birth Country/Region measure: Race measure: Blood group measure: BMI measure: Proportion of patients with comorbidities, including: autoimmune diseases, cancer, HIV infection, hypertension, type 2 diabetes, hypercholesterolemia, cardiovascular disease, chronic renal failure, liver disease, depression. measure: Proportion of acute iTTP episodes preceded by potential triggering factors including: infections, pregnancy, surgery, psychological trauma, vaccination, drugs measure: Incidence, type and severity of clinical manifestations, including: bleeding, cardiovascular, neurological, renal and systemic signs and symptoms measure: Platelet count lactate dehydrogenase (LDH), total and indirect bilirubin, liver transaminases, creatinine, troponin measure: Hemoglobin lactate dehydrogenase (LDH), total and indirect bilirubin, liver transaminases, creatinine, troponin measure: Lactate dehydrogenase (LDH) lactate dehydrogenase (LDH), total and indirect bilirubin, liver transaminases, creatinine, troponin measure: Creatinine lactate dehydrogenase (LDH), total and indirect bilirubin, liver transaminases, creatinine, troponin measure: Cardiac troponin measure: ADAMTS13 activity measure: Anti-ADAMTS13 antibodies measure: Number of daily therapeutic plasma exchange procedures measure: Proportion of acute iTTP patients treated with rituximab measure: Proportion of acute iTTP patients treated with immunosuppressors other than steroids and rituximab measure: Proportion of iTTP patients treated with caplacizumab measure: Incidence, type and severity of TTP-related drugs adverse events measure: Proportion of iTTP patients achieving clinical remission measure: Proportion of iTTP patients refractory to acute iTTP treatment measure: Proportion of iTTP patients experiencing complications during hospitalization, including: bleeding, thrombosis, neurological, renal, cardiac complications measure: Proportion of iTTP patients experiencing clinical exacerbation measure: Proportion of iTTP patients achieving ADAMTS13 remission measure: Time to clinical response measure: Time to clinical remission measure: Time to ADAMTS13 remission measure: Proportion of iTTP patients with a clinical relapse measure: Proportion of iTTP patients with an ADAMTS13 relapse measure: Time to clinical relapse measure: Time to ADAMTS13 relapse measure: Incidence, type and severity of pregnancy complications in iTTP pregnant women measure: iTTP incidence in Italy sex: ALL minimumAge: 12 Years maximumAge: 99 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06376773 id: 2022KY123 briefTitle: Neoadjuvant Treatment Based on Gastric Cancer Molecular Subtyping. overallStatus: COMPLETED date: 2022-06-01 date: 2023-07-01 date: 2023-11-30 date: 2024-04-19 date: 2024-04-19 name: Fujian Medical University class: OTHER briefSummary: Extensive research employing diverse omics methodologies has unveiled a varied landscape of gastric cancer (GC). Recent progress in next-generation sequencing and other genomic technologies has facilitated a more intricate exploration of GC at the molecular level. This study aimed to identify the most effective drug therapeutics for patients with the mesenchymal subtype of gastric cancer.Based on RNA-seq transcriptome, 234 patients were divided into four molecular subtypes: mesenchymal, immunogenic, metabolic, and classic.Our analysis has revealed that, for neoadjuvant therapy in advanced gastric cancer (AGC), the mesenchymal subtype stands out as the ideal patient population benefiting from Apatinib, without a concurrent increase in postoperative complications. conditions: Advanced Gastric Cancer conditions: Neoadjuvant Therapy conditions: Multi-omics Analysis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 234 type: ACTUAL name: combination chemotherapy with Apatinib or Camrelizumab measure: overall survival measure: objective response rate sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fujian Medical University Union Hospital city: Fuzhou state: Fujian zip: 350000 country: China lat: 26.06139 lon: 119.30611 hasResults: False
nctId: NCT06376760 id: KY2024-091-02 briefTitle: Changes in Intravenous Anesthetic Drug Dosage in Insomnia Patients Undergoing Digestive Endoscopy overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2027-03-31 date: 2027-03-31 date: 2024-04-19 date: 2024-04-19 name: Beijing Tiantan Hospital class: OTHER briefSummary: To compare the dosage requirement of intravenous anesthetics during digestive endoscopy between patients with insomnia and those with normal sleep pattern. conditions: Insomnia conditions: Digestive Endoscopy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 3360 type: ESTIMATED name: No interventions, it is a observational study measure: The total consumption of intravenous anesthetic drug measure: The dosage of intravenous anesthetic drug for successful insertion of digestive endoscope measure: The occurrence of the respiratory and cardiovascular adverse events measure: The occurrence of the other adverse events measure: The incidence of intraoperative recall or awareness measure: The recovery time measure: Duration of patients' PACU stay measure: The ease of operation at this level of sedation evaluated by the gastroenterologists measure: The satisfaction degree of anesthesia effect evaluated by the gastroenterologists measure: Patients' satisfaction measure: Patients' willingness sex: ALL minimumAge: 18 Years maximumAge: 64 Years stdAges: ADULT facility: Beijing Tiantan Hospital city: Beijing state: Beijing zip: 100070 country: China name: Fang Luo, M.D. role: CONTACT phone: 13611326978 email: 13611326978@163.com name: Fang Luo, M.D. role: PRINCIPAL_INVESTIGATOR lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06376747 id: KDAR- PBM 2024 briefTitle: The Influence of Blood Sampling Technique on the Total Amount of Blood Collected for Laboratory Testing Critically Ill Pediatric Patients acronym: PEDPBM overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-04-30 date: 2025-08-31 date: 2024-04-19 date: 2024-04-19 name: Brno University Hospital class: OTHER briefSummary: The aim of this prospective randomized study is to evaluate blood loss caused by laboratory blood draws in patients in the paediatric ICU (Intensive Care Unit) of a tertiary hospital among two groups of patients with established long-term or mid-term intravenous access. In the first group, patients will undergo blood draws using the standard method. In the second group of patients, blood draws will be performed using a closed system. conditions: Iatrogenic Anaemia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: SINGLE maskingDescription: Patients will be randomized into two groups: a group with standard blood sampling technique and a group with closed technique blood sampling by using randomizing software. whoMasked: INVESTIGATOR count: 100 type: ESTIMATED name: In line sampling name: Standard blood sampling technique measure: Average amount of blood collected for laboratory diagnostic purposes measure: Cumulative amount of blood drawn per day of ICU hospitalization measure: Absolute amount of blood drawn and blood used for laboratory testing measure: Trend of haemoglobin decline over time measure: Incidence of anaemia measure: Incidence of anaemia up to transfusion trigger measure: Frequency of blood product transfusions and their quantity measure: Type and frequency of laboratory tests measure: Incidence of coagulopathy measure: Incidence of catheter-related complications measure: Time to catheter replacement in case of catheter exchange sex: ALL minimumAge: 1 Month maximumAge: 19 Years stdAges: CHILD stdAges: ADULT facility: KDAR - department of pediatrics anesthesia and resuscitation city: Brno zip: 62500 country: Czechia lat: 49.19522 lon: 16.60796 hasResults: False