hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06309160 id: R324A230008 briefTitle: COMPASS Across Settings (CAST) for Improving Transition Outcomes for Students With ASD acronym: CAST overallStatus: RECRUITING date: 2023-12-01 date: 2027-07 date: 2027-07 date: 2024-03-13 date: 2024-03-13 name: Ball State University class: OTHER name: University of Toledo name: Indiana University briefSummary: Purpose: The purpose of this project is to develop and test the COMPASS \[Collaborative Model for Competence and Success\] Across Settings (CAST) intervention to enhance the goal setting and attainment skills of autistic youth. Despite federal education law mandating transition services as part of the Individualized Education Program (IEP) for ensuring good outcomes for students with disabilities, current educational practices have been unable to demonstrate that autistic students experience positive postsecondary outcomes. There are existing, evidence-based interventions aimed at supporting positive outcomes for these students. However, these interventions have not systematically provided coaching support to the caregivers, students, and employment specialists. To address these issues, CAST will integrate three evidence-based interventions for supporting student transitions while providing this critical coaching support. By doing so, CAST aims to align the priorities and goals of interventions across home, school, and community settings to better support positive postsecondary outcomes for autistic students. conditions: Autism conditions: Autism Spectrum Disorder conditions: Autistic Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Pre-post; randomized control primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Independent observer evaluating goal attainment outcomes whoMasked: OUTCOMES_ASSESSOR count: 297 type: ESTIMATED name: COMPASS Across Settings (CAST) measure: Goal Attainment of IEP progress (Ruble et al., 2012; 2018). measure: Attainment of Postsecondary Goals (Ruble et al., 2019) measure: Fidelity Assessment of Initial CAST consultation (Ruble et al., 2018) measure: Fidelity Assessment of CAST Coaching (Ruble et al., 2018) measure: Organizational Connectedness measure: Transition Plan Quality (Ruble et al., 2019) sex: ALL minimumAge: 16 Years maximumAge: 99 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Ball State University status: RECRUITING city: Muncie state: Indiana zip: 47306 country: United States name: Lisa Ruble, PhD role: CONTACT phone: 765-285-5702 email: laruble@bsu.edu lat: 40.19338 lon: -85.38636 hasResults: False
nctId: NCT06309147 id: ALX-923-107 briefTitle: A Study to Assess the Safety of BMS-984923 Compared to Placebo, in People With Parkinson's overallStatus: RECRUITING date: 2024-03-15 date: 2025-02-15 date: 2025-07-15 date: 2024-03-13 date: 2024-03-18 name: Allyx Therapeutics class: INDUSTRY name: Michael J. Fox Foundation for Parkinson's Research briefSummary: A Phase 1, randomized, double-blind, placebo-controlled study of BMS-984923 administered orally twice daily (BID) for 28 days in participants with Parkinson's disease. conditions: Parkinson Disease studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Double blind, parallel, 3-arm, placebo controlled primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Matching placebo whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 18 type: ESTIMATED name: BMS-9894923 measure: Incidence of treatment-emergent adverse events (TEAEs) measure: Area under the curve for the first 24 hours of dosing (AUC24h) and at steady state as determined by pharmacokinetic modeling measure: To evaluate changes in α-synuclein measure: Change from baseline dopamine transporter measure: Assess changes in motor function sex: ALL minimumAge: 50 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Duke Clinical Research Institute status: RECRUITING city: Durham state: North Carolina zip: 27701 country: United States name: Alexis Schuettke role: CONTACT phone: 919-668-2842 email: alexis.schuettke@duke.edu lat: 35.99403 lon: -78.89862 hasResults: False
nctId: NCT06309121 id: PIC-11-24 briefTitle: Effects of the Postbiotic Blend ABB C3 on Adiposity and Glucose Metabolism in Children and Adolescents acronym: PostOb overallStatus: RECRUITING date: 2024-04-10 date: 2025-01-31 date: 2025-04-30 date: 2024-03-13 date: 2024-04-22 name: Fundació Sant Joan de Déu class: OTHER briefSummary: This study investigates the effects of a postbiotic combination called ABB C3 on reducing body fat and improving metabolic health in children and teenagers. The study consists of a 3-month trial with half participants taking ABB C3 and the other half a placebo, monitoring body composition and blood markers. Afterward, participants can continue with ABB C3 for an additional 3 months. The goal is to determine if ABB C3 is a safe and effective way to help young people improve their health by reducing body fat. conditions: Obesity, Childhood conditions: Obesity, Adolescent studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized double-blind placebo-controlled study with a treatment group and an active control parallel group. primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 70 type: ESTIMATED name: Postbiotic ABB C3 name: Placebo name: Follow-up Postbiotic ABB C3 (Optional) measure: Incidence of Adverse Events measure: Change in adiposity (% fat body mass) measure: Change in blood glycated hemoglobin (HbA1c) levels measure: Change in adiposity (% fat body mass) measure: Change in blood glycated hemoglobin (HbA1c) levels measure: Change in BMI z-score measure: Change in body composition measure: Change in insulin sensitivity measure: Change in lipid profile (triglycerides, cholesterol) measure: Change in blood pressure measure: Change in Beck Depression Inventory-II (BDI-2) measure: Change in Beck Anxiety Inventory-II (BAI-2) measure: Change in gut microbial abundance and diversity measure: Change in plasma metabolite concentrations sex: ALL minimumAge: 8 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Hospital Sant Joan de Déu status: RECRUITING city: Barcelona zip: 08950 country: Spain name: Marta Ramon Krauel, MD PhD role: CONTACT phone: (+34) 932804000 phoneExt: 71263 email: marta.ramon@sjd.es name: Carles Lerin, PhD role: PRINCIPAL_INVESTIGATOR lat: 41.38879 lon: 2.15899 hasResults: False
nctId: NCT06309108 id: 2022/68-04 id: İUC type: OTHER domain: İUC briefTitle: Bariatric Surgery and Patient Education overallStatus: COMPLETED date: 2022-01-02 date: 2022-05-02 date: 2023-07-18 date: 2024-03-13 date: 2024-03-13 name: Istanbul University - Cerrahpasa (IUC) class: OTHER briefSummary: Obesity is a disease that poses a health risk and is increasing worldwide. Bariatric surgery is the most effective method used in the treatment of obesity. Preoperative health education for bariatric surgery patients is important to support surgery. There is not enough nursing research in the literature regarding training patients with two different materials before bariatric surgery. The purpose of the randomized controlled experimental study designed in light of this information was to determine the effect of education given to patients with two different materials before bariatric surgery on early complications. The rates of the study were determined by randomizing trial I, trial II, and control treatment in 66 rooms that met the interval and study screening criteria offered between May 2022 and June 2023 in the general surgery service of a university hospital. Data from the research; was collected with the Veria Total Form, Autar Risk Assessment Scale, Apfel Risk Score, Visual Comparison Scale-VAS (Visual Analog Scale-VAS), Training Satisfaction Survey, and Complication Monitoring Form. In the first face-to-face meeting in the experimental groups, we were given training by the researcher with the removable Training Booklet I and Training Booklet II and were monitored until discharge. No control group training was given. conditions: Bariatric Surgery Candidate conditions: Education conditions: Patient Education studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: In our study, patients who would undergo bariatric surgery were selected randomly. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 66 type: ACTUAL name: Education Booklet name: Augmented Reality Group measure: Veria Total Form for sociodemographic features measure: Autar Risk Assessment Scale for DVT measure: Apfel Risk Score for nausea and vomiting measure: Visual Analog Scale-VAS for pain measure: Training Satisfaction Survey measure: Complication Monitoring Form to determine whether complications develop sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: İstanbul University- Cerrahpasa Instutite Graduate Studies city: İstanbul state: Avcılar zip: 34320 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06309095 id: AFSU_AhmetDemirhanUygun_001 briefTitle: Investigation of the Effect of Low Torque and Speed on Post-Operative Pain After Root Canal Treatment overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-03-15 date: 2024-04-15 date: 2024-03-13 date: 2024-03-13 name: Afyonkarahisar Health Sciences University class: OTHER briefSummary: Root canal preparation is one of the most important stages in root canal treatment. Nowadays, the use of Nickel-Titanium(Ni-Ti) rotary instrument systems for root canal expansion is becoming very popular. The force required to rotate the Ni-Ti file is defined as the torque force and is considered a parameter for the stress produced within the canal. Ni-Ti rotary instruments can be used with a wide speed scale between 150 rpm (rotary per minute) and 40,000 rpm in conventional endodontic engines.
Low torque and speed values mean low pressure applied by the instruments in the root canal. With low forces and vibrations, motor noise is generally negligible, and the instruments can easily shape most root canals in a reasonable amount of time and with minimal mechanical stress (in medium-easy canals). The use of lower torque values has been shown to reduce cyclic fatigue of Ni-Ti rotary tools. With reduced cyclic fatigue, the risk of instrument breakage in complex root canal morphologies is minimized and complications that may occur during root canal treatment are reduced. However, with low torque and speed values, cutting efficiency decreases and the process time increases as the instrument advances in the canal and during possible treatment. Decreasing cutting efficiency may also result in the operator applying force to move through the canal. With the applied force, the friction resistance within the canal increases and the heat produced increases. For this reason, it is thought that the risk of post-operative pain may increase during or after the procedure.
The aim of this study is to investigate the incidence of post-operative pain and procedure time using the visual analog scale (VAS) among groups where low torque and speed values were applied during the use of the Ni-Ti rotary instrument system. conditions: Dental Pulp Necrosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 80 type: ESTIMATED name: use of VDW Silver Endodontic motor measure: Visual analog scale measure: Preparation time sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Afyonkarahisar Health Science University city: Afyonkarahisar zip: 03030 country: Turkey name: Ahmet D Uygun, Assoc. Prof. role: CONTACT phone: +905057513705 email: ademirhan100@hotmail.com name: Betül Karaağaç, R.A. role: CONTACT phone: +905347934602 email: karaagacbetull@gmail.com lat: 38.75667 lon: 30.54333 hasResults: False
nctId: NCT06309082 id: DFU briefTitle: Assessing Diabetic Foot Ulcer Microcirculation With High-frequency Contrast Enhanced Ultrasound overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2026-12 date: 2026-12 date: 2024-03-13 date: 2024-03-13 name: First Affiliated Hospital of Wenzhou Medical University class: OTHER briefSummary: The objective of this observational study is to investigate and validate the utility of high-frame-rate ultrasound imaging technology for dynamic observation of the blood perfusion process at the site of ulcer wounds in real-time, focusing on patients with Diabetic Foot Ulcers (DFU). The primary research questions it seeks to address are as follows:
Researchers will compare ulcerated sites with normal sites to see whether the use of High-Frequency Contrast-Enhanced Ultrasound (H-CEUS) has any discernible impact on the visualization of microcirculation in ulcer wounds. conditions: Diabetes Mellitus studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED measure: H-CEUS score sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: the First Affiliated Hospital the First Affiliated Hospital city: Wenzhou state: Zhejiang zip: 325006 country: China name: Shihao Xu role: CONTACT phone: 13857766918 email: dcxshvip@wmu.edu.cn name: Shihao Xu role: PRINCIPAL_INVESTIGATOR lat: 27.99942 lon: 120.66682 hasResults: False
nctId: NCT06309069 id: LOCAL/2024/TP-01 id: IRB 24.01.01 type: OTHER domain: CHU de Nîmes briefTitle: Calcified Cerebral Embolism: a Descriptive Study in a Large Single Center Cohort acronym: CCE Cohorte overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-04 date: 2024-04 date: 2024-03-13 date: 2024-03-13 name: Centre Hospitalier Universitaire de Nīmes class: OTHER briefSummary: Calcified cerebral embolism (CCE) is a relatively rare but underdiagnosed cause of infarction. CCE diagnosis is made by CT. Radiological characteristics of CCE have been reported in small case series. The aim of this study was to describe clinical and radiological characteristics of CCE in a large number of patients, and to compare patients with different radiological CCE characteristics. conditions: Calcified Cerebral Embolism studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 79 type: ESTIMATED name: None, purely observational study measure: Calcified aortic brachiocephalic measure: cardiovascular risk measure: history of stroke measure: Population measure: Population measure: history of surgical/endovascular cardiovascular intervention measure: NIHSS measure: calcified aortic arch measure: calcified carotid measure: atherosclerotic plaques measure: calcified aortic valves measure: calcified mitral valves measure: CCE diameter measure: density measure: involved cerebral artery sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU de Nîmes city: Nîmes zip: 30029 country: France name: Teodora PARVU role: CONTACT phone: +33466685008 email: teodora.parvu@chu-nimes.fr lat: 43.83333 lon: 4.35 hasResults: False
nctId: NCT06309056 id: MP-05-2024-3903 briefTitle: Neuromuscular Electrical Stimulation for Children With Dysphagia overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-03 date: 2026-03 date: 2024-03-13 date: 2024-03-13 name: Sir Mortimer B. Davis - Jewish General Hospital class: OTHER briefSummary: This study aims to measure if using neuromuscular electrical stimulation (NMES) effectively improves swallowing, drooling (if applicable), feeding ability, physical growth and quality of life in children with severe dysphagia. This pilot study is for children aged over 18 months old with dysphagia. It aims to investigate a new approach to help children improve their swallowing function. Some published studies have shown that electrical stimulation to muscles involved in swallowing may help children with dysphagia.
In this pilot study, NMES will be used. This procedure delivers electrical stimulation to make participants' muscles contract. Electrodes are placed on the skin, over the muscles that help with swallowing, and an electric current is delivered through wires which are connected to a small machine. The current is controlled through a small, handheld device. NMES will be applied to muscles involved in eating, drinking and swallowing. NMES will be applied to the participant alongside their regular treatment. No medications or treatments will be added, modified or discontinued as part of this study.
The overall duration of the study per participant will last a total of nine months. For the first three months, the participant will receive the NMES twice a week. There will be no interventions or follow-up appointments scheduled for the following 6 months. Then, there will be a final follow-up meeting 9 months following the start of the intervention to evaluate for lasting changes. conditions: Dysphagia studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients being followed at the Lethbridge-Layton-Mackay Rehabilitation Centre Salivation Management Clinic and the Dysphagia and Feeding Disturbance Clinic who meet inclusion criteria will be recruited. If caregivers/participants consent to the study, they will be enrolled in the intervention arm. Any potentially eligible participant who declines to participate in the study will be recruited as a control group. These participants will complete the questionnaires at the same timepoints as the interventional group and data from the medical charts will be included in the study. primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: VitalStim measure: Feeding Intake - Functional Oral Intake Scale measure: Penetration and Aspiration Scale measure: Quality of Life - Pediatric Quality of Life Inventory 4.0 Generic Core Scale for Toddlers, Young Children, Children 8-12 years old OR Teenagers. measure: Body Mass Index (kg/m^2) sex: ALL minimumAge: 18 Months maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06309043 id: HLX05-001 briefTitle: A Randomized, Single Intravenous Dose, Parallel Phase I Clinical Study to Compare the Pharmacokinetic Characteristics, Safety, and Immunogenicity of HLX05 Vs. Erbitux® (Cetuximab) in Healthy Adult Male Chinese Subjects overallStatus: NOT_YET_RECRUITING date: 2024-04-12 date: 2025-06-01 date: 2025-12-31 date: 2024-03-13 date: 2024-03-13 name: Shanghai Henlius Biotech class: INDUSTRY briefSummary: This is a randomized, single intravenous dose, parallel study to compare the PK characteristics, safety, tolerability, and immunogenicity of HLX05 vs. Erbitux® (US-, EU-, and CN-sourced) in healthy adult male Chinese subjects. This study is divided into two parts. conditions: EGFR Overexpression studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 268 type: ESTIMATED name: recombinant anti-EGFR human/murine chimeric monoclonal antibody injection measure: AUC0-inf measure: Cmax measure: Tmax measure: CL measure: λz sex: MALE minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT hasResults: False
nctId: NCT06309030 id: ZRJY2023-QM21 briefTitle: Clinical Study on the Deep Remission of Rheumatoid Arthritis With Kidney Deficiency and Excessive Cold Syndrome by Bushen Quhan Zhiwang Decoction overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-12-31 date: 2026-08-01 date: 2024-03-13 date: 2024-03-13 name: Liu Longxiao class: OTHER briefSummary: The investigators conduct this randomized controlled clinical trial to evaluate the efficacy and safety of the Bushen Quhan Zhiwang decoction in patients with RA with kidney deficiency and excessive cold syndrome who have not achieved deep remission and remained at a low level of disease activity despite the use of conventional synthetic disease-modifying antirheumatic drugs. conditions: Rheumatoid Arthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 72 type: ESTIMATED name: Bushen quhan zhiwang decoction name: Bushen quhan zhiwang decoction placebo measure: disease activity score derivative for 28 joints (DAS28) measure: patient reported outcomes（PRO） measure: visual analogue scale for pain measure: withdrawl mechanical threshold measure: erythrocyte sedimentation Rate（ESR） measure: C-reactive protein（CRP） measure: TCM symptom score sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06309017 id: 23-01243 briefTitle: Pre-operative Nutrition for Elective Resection Surgery in Inflammatory Bowel Disease overallStatus: NOT_YET_RECRUITING date: 2024-03-10 date: 2024-12 date: 2025-04 date: 2024-03-13 date: 2024-03-13 name: NYU Langone Health class: OTHER briefSummary: This study aims to determine if improved risk stratification tools and interventions to mitigate malnutrition reduce postoperative risk in patients undergoing elective or emergent resection surgery for inflammatory bowel disease (IBD), and if adding immune modulation nutrition improves surgical outcomes. The primary objective is to assess whether preoperative malnutrition screening and intervention minimize postoperative complications. The secondary objective is to evaluate whether immune modulation nutrition in the peri-operative period decreases length of stay and major complications. conditions: Inflammatory Bowel Diseases studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 150 type: ESTIMATED name: Nutrition specialist name: Ensure Surgery Immunonutrition shakes measure: Length of hospital stay measure: Proportion of patients who experienced postoperative major complications measure: Proportion of patients who participated in a nutritional intervention program before surgery measure: Proportion of patients who participated in a nutritional intervention program after surgery measure: Number of nutritional shakes completed measure: Percentage of nutritional shakes completed overall measure: Percentage of nutritional shakes completed pre-surgery measure: Percentage of nutritional shakes completed post-surgery measure: Proportion of patients who experienced any postoperative complications measure: Proportion of patients with 30 day readmission sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: NYU Langone Health city: New York state: New York zip: 10016 country: United States lat: 40.71427 lon: -74.00597 hasResults: False
nctId: NCT06309004 id: 2023-00741a briefTitle: Development of an Online ACT Intervention for Disorders of Gut-Brain Interaction acronym: iACTforDGBI overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-07-01 date: 2024-08-31 date: 2024-03-13 date: 2024-03-13 name: Örebro University, Sweden class: OTHER briefSummary: The goal of this clinical trial is to develop and test the iACTforDGBI intervention in a sample of Swedish individuals with DGBI (Disorders of Gut-Brain Interaction).
Participants (individuals with symptoms compatible with a DGBI and anxiety and/or depression, and healthcare professionals working in DGBI) will be asked to: a) Evaluate a preliminary version of the iACTforDGBI intervention, consisting of self-guided online sessions. b) Participate in online focus-group interviews and provide information on their views of a preliminary version of the iACTforDGBi intervention conditions: Clinically Meaningful Symptoms Levels of Symptoms of DGBI and Depression and/or Anxiety studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 30 type: ESTIMATED measure: Focus group interviews sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False