hackint0sh/New-Dataset huggingface dataset:
The present study investigates the effects of 8 weeks of TRE associated with aerobic training in a fasted state versus a fed state on body composition and cardiometabolic parameters in women with overweight and grade 1 obesity. conditions: Time Restricted Eating conditions: Obesity conditions: Intermittent Fasting conditions: Overweight and Obesity conditions: Time Restricted Feeding studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Dietary and Exercise Approaches name: Dietary and Exercise Approaches name: Dietary Approach measure: Insulin sensitivity (indices) measure: Insulin resistance (indices) measure: Fasting insulin levels (µIU/mL) measure: Fasting glucose levels (mg/dL) measure: Glucose tolerance measure: Fasting lipid profile levels measure: β cell function (indices) measure: Fat Mass (kg) measure: Fat Percentage (%) measure: Fat Free Mass (kg) measure: Body Weight (kg) measure: Body Weight (kg) measure: Bone Mineral Content (kg) measure: Body Mass Index (kg/m^2) measure: Fasting ketones (β-hydroxybutyrate) levels (mmol/L) measure: Resting metabolic rate (Kcal/day) measure: Substrate Oxidation (respiratory exchange ratio) measure: Absolute Peak oxygen consumption measure: Relative Peak oxygen consumption measure: Fasting Leptin Levels measure: Fasting Adiponectin Levels measure: Inflammatory Markers Levels measure: LDL-cholesterol levels measure: Non-HDL-cholesterol levels sex: FEMALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT hasResults: False
nctId: NCT06302218 id: 5/2024 briefTitle: ESPB vs iPACK+ACB in Total Knee Arthroplasty overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-09-30 date: 2025-10-30 date: 2024-03-08 date: 2024-03-08 name: Poznan University of Medical Sciences class: OTHER briefSummary: Effect of iPACK block with Adductor Canal Block and ESPB on pain management, and NLR and PLR following knee arthroplasty conditions: Knee Arthritis conditions: Knee Arthropathy conditions: Knee Osteoarthritis conditions: Knee Pain Chronic conditions: Knee Disease conditions: Knee Rheumatism studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Ropivacaine 0.2% Injectable Solution name: Ropivacaine 0.2% Injectable Solution name: control group measure: Opioid consumption measure: Time to first rescue opiate analgesia measure: Numerical Rating Scale [range 0:10] measure: Numerical Rating Scale [range 0:10] measure: Numerical Rating Scale [range 0:10] measure: Numerical Rating Scale [range 0:10] measure: Numerical Rating Scale [range 0:10] measure: Numerical Rating Scale [range 0:10] measure: Numerical Rating Scale [range 0:10] measure: Numerical Rating Scale [range 0:10] measure: Neutrophil-to-lymphocyte ratio measure: Neutrophil-to-lymphocyte ratio measure: Platelet-to-lymphocyte ratio measure: Platelet-to-lymphocyte ratio measure: Quadriceps muscle strength assessed using medical research council scale [range 0:5] sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Poznan University of Medical Sciences city: Poznan state: Poznań zip: 61-701 country: Poland lat: 52.40692 lon: 16.92993 hasResults: False
nctId: NCT06302205 id: S66232 briefTitle: A Home-based Exercise and Physical Activity Intervention After Liver Transplantation: Impact of Exercise Intensity acronym: PHOENIX-L overallStatus: RECRUITING date: 2023-03-01 date: 2026-01 date: 2026-12 date: 2024-03-08 date: 2024-04-01 name: Universitaire Ziekenhuizen KU Leuven class: OTHER name: KU Leuven briefSummary: Research demonstrated that transplant recipients benefit from physical activity, but there is a gap in knowledge regarding the required intensity. In the PHOENIX-Liver study, researchers aim to investigate the adequate intensity of rehabilitation programs after liver transplantation. Patients will be randomized into one of the three PHOENIX-Liver training groups (low, moderate, moderate to high). The six months rehabilitation program is conducted from the patient's home but supervised by a PHOENIX-investigator.
To gather information on the potential for implementation in a real-world setting, a 15-month-long physical activity phase will start after the intervention phase. This entails a maintenance physical activity program tailored to the patients' preferences. A follow-up at UZ Leuven is planned at three and at 15 months where the same clinical evaluations will be conducted as during the test moments of the intervention phase. conditions: Liver Transplantation conditions: Physical Fitness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two interventional groups and one control group primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The nature of the intervention does not allow blinding of study participants. However, outcome assessors and data investigators will be blinded to the participants' group allocation. whoMasked: OUTCOMES_ASSESSOR count: 147 type: ESTIMATED name: Physical activity name: Sham intervention measure: Cardiorespiratory fitness measure: Functional exercise capacitiy measure: Hand grip strength measure: Knee-extensor strength measure: Endothelial function measure: Arterial stiffness measure: Graft function measure: Occurence of adverse events measure: Motor fitness measure: Blood pressure measure: Blood profile sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UZ Leuven status: RECRUITING city: Leuven state: Vlaams-Brabant zip: 3000 country: Belgium name: Hanne Van Criekinge role: CONTACT phone: +3216343162 email: hanne.vancriekinge@kuleuven.be name: Diethard Monbaliu, MD PhD role: PRINCIPAL_INVESTIGATOR lat: 50.87959 lon: 4.70093 hasResults: False
nctId: NCT06302192 id: 4302 briefTitle: Renal Doppler to Predict Acute Kidney Injury (AKI) in ARDS Patients. (RED-AKI Study) acronym: RED-AKI overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-01-31 date: 2026-06-30 date: 2024-03-08 date: 2024-03-08 name: Policlinico Hospital class: OTHER briefSummary: This is a multicenter international observational prospective cohort study. The main questions it aims to answer are:
* SECONDARY AIMS: A)Describe the capability of IRVF demodulation or pattern of IRVF (continuous, pulsatility, biphasic, monophasic) to predict development of AKI within 14 days from the ARDS onset. B) To describe the RD parameters and VexUS in the AKI and no AKI patients over time. C) Describe the impact of invasive mechanical ventilation (IMV) on the intrarenal venous congestion and VexUS., D) Evaluation of effect of CRRT on IRVF pattern, VexUS and parameters. E) Describe the feasibility of renal doppler to assess IRVF in critically ill respiratory patients. F) Evaluate the incidence of AKD and CKD Participants will Adult patients with diagnosis of ARDS admitted to intensive care unit and undergoing invasive mechanical ventilation conditions: Acute Kidney Injury conditions: ARDS, Human studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 164 type: ESTIMATED name: ARDS+AKI measure: cumulative incidence measure: AKI14 measure: AKIstage measure: cross talk lung-kidney measure: CRRT measure: incidence of failed exam measure: CKD progression sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06302179 id: 140-14/24 briefTitle: Risk Factors of Venous Thromboembolism After Colorectal Cancer Surgery overallStatus: COMPLETED date: 2015-01 date: 2017-12 date: 2023-05 date: 2024-03-08 date: 2024-03-08 name: Pirogov Russian National Research Medical University class: OTHER briefSummary: Aim of our study is to find frequency and identify risk factors for venous thromboembolism development in patients who underwent surgery for colorectal cancer. There were 137 patients enrolled in our retrospective observational cohort study. Included patients were operated for incisional hernia in Saveljev University Surgery Clinic from January 2016 to December 2017. Compression duplex ultrasound of lower legs veins was performed in 2-14 days after surgery for all participants. The primary endpoint was the occurrence of the venous thromboembolism event, including pulmonary embolism. conditions: Colorectal Cancer conditions: Venous Thromboembolism studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 137 type: ACTUAL measure: Venous Thromboembolism sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pirogov Russian National Research Medical University city: Moscow zip: 117997 country: Russian Federation lat: 55.75222 lon: 37.61556 hasResults: False
nctId: NCT06302166 id: HafsaJaved briefTitle: Effects of HICT and Intermittent Fasting on PCOS overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-07-01 date: 2024-07-01 date: 2024-03-08 date: 2024-03-08 name: Riphah International University class: OTHER briefSummary: The goal of this randomized controlled trial is to compare the effects of High intensity circuit training, Intermittent Fasting, and their combination on PCOS morphology, Anthropometrics, clinical hyperandrogenism and body image concerns in females with PCOS.
Participants will be divided into three groups who will receive High intensity circuit training, Intermittent fasting and their combination. The outcomes will be PCOS morphology, anthropometrics', clinical hyperandrogenism and body image concerns. conditions: Polycystic Ovary Syndrome conditions: PCO studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 33 type: ESTIMATED name: High Intensity Circuit training (HICT) name: Intermittent Fasting (IF) name: Combination of HICT and IF measure: PCOS Morphology measure: Anthropometrics measure: Clinical Hyperandrogenism measure: Body Image concerns sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: AlMuratza Hospital city: Rawalpindi state: Punjab zip: 44000 country: Pakistan name: Sarah Ehsan, PP-DPT role: CONTACT phone: 03217770829 email: sarah.ehsaan@riphah.edu.pk name: Hafsa Javed, DPT role: PRINCIPAL_INVESTIGATOR lat: 33.6007 lon: 73.0679 hasResults: False
nctId: NCT06302153 id: amnashahid briefTitle: Progressive Loading Exercises and Conditioning Exercises on Calf Strain acronym: runners overallStatus: COMPLETED date: 2023-06-01 date: 2024-02-10 date: 2024-02-10 date: 2024-03-08 date: 2024-03-08 name: Riphah International University class: OTHER briefSummary: Calf pain is a common complaint among runners of all ages but is most frequent in masters athletes. The most common calf injury is a tear of the medial gastrocnemius muscle (Tennis Leg) but other structures including the lateral gastrocnemius, plantaris and soleus also may be the cause of muscular pain.There are multiple techniques for the management that involves loading the strained calf musculature through rest, taping techniques, and appropriate soft tissue massage techniques, modalities such as dry needling or western acupuncture can be popular amongst runners and may also be useful. Progressive loading is a principle of resistance training exercise program design that typically relies on increasing load to increase neuromuscular demand to facilitate further adaptations whereas Athletic performance is based on a number of skills that can be developed through a sports conditioning program. This particular program focuses on improving both muscular strength and power using a technique called post-activation potentiation (PAP), also commonly referred to as complex training. conditions: Range of Motion, Pain, Sports Injuries, Stretching, Triceps Surae studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 40 type: ACTUAL name: Progressive Loading Exercises measure: pain , range of motion, functions sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Jawad club, Alfatah sports complex city: Faisalābad state: Punjab zip: 38000 country: Pakistan lat: 31.41554 lon: 73.08969 facility: Riphah International University, Raiwind Campus city: Faisalābad state: Punjab zip: 5400 country: Pakistan lat: 31.41554 lon: 73.08969 hasResults: False
nctId: NCT06302140 id: VT3996-102 briefTitle: A Mass Balance Study of [14C]-Nanatinostat and Relative Bioavailability Study of Nanatinostat in Patients With Advanced Cancers overallStatus: RECRUITING date: 2024-02-28 date: 2025-02 date: 2025-10 date: 2024-03-08 date: 2024-03-29 name: Viracta Therapeutics, Inc. class: INDUSTRY briefSummary: This study will determine how nanatinostat is absorbed, modified, and removed from the body (Part A), the amount of nanatinostat that becomes available to the body (Part B), and will evaluate the safety and tolerability of nanatinostat (Part C) in patients with advanced cancers. conditions: Advanced Cancer studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: This clinical trial is divided into 3 parts (Part A, Part B, and Part C).
Part C will allow patients to continue receiving nanatinostat treatment as long as they are deriving clinical benefit. This part will not require a hospital stay. primaryPurpose: BASIC_SCIENCE masking: NONE count: 14 type: ESTIMATED name: [14C]-Nanatinostat name: Nanatinostat (free base) tablets in combination with Valganciclovir name: Nanatinostat mesylate tablets in combination with Valganciclovir name: Single-agent Nanatinostat (free base) tablets measure: The amount of radioactivity in excreta [Part A] measure: Pharmacokinetic Parameter: area under the plasma concentration versus time curve (AUC) [Part B] measure: Pharmacokinetic Parameter: maximum plasma concentration (Cmax) [Part B] measure: Pharmacokinetic Parameter: time to maximum observed plasma concentration (Tmax) [Part B] measure: Pharmacokinetic Parameter: Fraction of the administered dose in comparison with a standard (Frel) [Part B] measure: Incidence of adverse events and serious adverse events [Part C] measure: Incidence of adverse events and serious adverse events [Parts A and B] measure: Incidence of clinically significant changes in selected safety assessments [Parts A and B] measure: Pharmacokinetic Parameter: area under the plasma concentration versus time curve (AUC) [Part A] measure: Pharmacokinetic Parameter: maximum plasma concentration (Cmax) [Part A] measure: Pharmacokinetic Parameter: time to maximum observed plasma concentration (Tmax) [Part A] measure: Pharmacokinetic Parameter: elimination half-life (t1/2) [Part A] measure: Pharmacokinetic Parameter: apparent total clearance (CL/F) [Part A] measure: Pharmacokinetic Parameter: apparent volume of distribution during terminal phase (Vz/F) [Part A] measure: Pharmacokinetic Parameter: elimination rate constant from the central compartment (Kel) [Part A] measure: The ratio of total radioactivity in blood relative to plasma [Part A] measure: [14C]-metabolic profile and identification of metabolites in plasma [Part A] measure: Major radioactive peak/metabolites in urine and fecal radiochromatograms as a percentage of the radioactive dose [Part A] measure: Pharmacokinetic Parameter: elimination half-life (t1/2) [Part B] measure: Pharmacokinetic Parameter: metabolite-to-parent ratio [Part B] measure: Objective Response Rate (ORR) [Part C] measure: Time to Response (TTR) [Part C] measure: Duration of Response (DOR) [Part C] measure: Disease Control Rate (DCR) [Part C] sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: START Madrid - CIOCC - Hospital Universitario HM Sanchinarro status: RECRUITING city: Madrid zip: 28050 country: Spain role: CONTACT email: ClinicalTrials@Viracta.com lat: 40.4165 lon: -3.70256 hasResults: False
nctId: NCT06302127 id: CCHDS briefTitle: County Medical Community-based, Cardiovascular Risk Stratified Integrated Care Model: a Pragmatic Cluster Randomised Control Trial acronym: RISIMA overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2025-04-20 date: 2025-05-20 date: 2024-03-08 date: 2024-03-08 name: Peking University class: OTHER briefSummary: The goal of this cluster randomized trial is to evaluate the effectiveness of the RISIMA model based on an integrated county healthcare consortium implemented by multi-level family health teams (FHTs)on patients with diabetes and/or hypertension, including CVD risk assessment, treatment, and management. conditions: Hypertension conditions: Diabetes Mellitus Type 2 conditions: Cardiovascular Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE maskingDescription: The follow-up data collection, data entry, and data quality checks will be conducted by researchers unaware of the group assignments. The analysis of results will also be performed by statisticians unaware of the allocation. whoMasked: OUTCOMES_ASSESSOR count: 2560 type: ESTIMATED name: Team-based care name: Risk-stratified care pathway name: Strengthened health education name: Financial incentives for integration of care name: Supporting health information system measure: CVD 10-year risk measure: CVD incidence rate measure: systolic blood pressure measure: total cholesterol sex: ALL minimumAge: 40 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06302114 id: Tubitak briefTitle: Upper Extremity Asymmetries in Overhead Athletes overallStatus: RECRUITING date: 2023-12-01 date: 2024-03-27 date: 2024-03-30 date: 2024-03-08 date: 2024-03-26 name: Pamukkale University class: OTHER name: Tübitak briefSummary: Although overhead sports have different characteristics, the movements in the shoulder and upper extremity are similar. These sports may involve a combination of symmetrical, asymmetrical, bilateral and unilateral movements. In sports involving asymmetric movements, biomechanical changes are observed in that area due to the use of the dominant extremity. One of the reliable methods to reveal the stress effects caused by biomechanical stresses is to determine limb asymmetries. Considering the literature, limb asymmetries may be related to injury and performance. conditions: Extremity Asymmetries conditions: Injury;Sports conditions: Performance studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 58 type: ESTIMATED name: Assessment of overhead athletes measure: Medicine ball forward throw measure: Y balanced test measure: Range of motion of internal and external rotation measure: Strength of Internal and External Rotator Muscles sex: ALL minimumAge: 15 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Pamukkale University status: RECRUITING city: Pamukkale state: Denizli zip: 20000 country: Turkey name: Fatma Ünver role: CONTACT email: funver@pau.edu.tr name: Erhan Kızmaz role: CONTACT phone: +905418966676 email: erhankizmaz@hotmail.com lat: 37.91644 lon: 29.11729 hasResults: False
nctId: NCT06302101 id: Exercise in older adults briefTitle: Telerehabilitation Exercise in Older Adults overallStatus: RECRUITING date: 2024-02-21 date: 2024-04-18 date: 2024-04-30 date: 2024-03-08 date: 2024-03-08 name: Pamukkale University class: OTHER briefSummary: The aim of this study was to investigate the effectiveness of chair-based exercises and cognitive exercises through synchronous telerehabilitation in older adults.
Older adults will be divided into two groups (intervention group n=16; control group n=16) . conditions: Pain conditions: Elderly conditions: Balance studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 32 type: ESTIMATED name: chair-based exercises name: cognitive exercises measure: Berg Balance Scale measure: Timed Up and Go Test During Dual Tasking measure: Geriatric Pain Measure measure: Older people's quality of life-brief (OPQOL-brief) measure: Hodkinson Mental Test measure: Dominant Side One Leg Stand Test measure: Timed Up and Go Test measure: chair sit and stand test measure: Geriatric Depression Scale measure: Successful Aging Scale sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Elif Gur Kabul status: RECRUITING city: Usak state: Center zip: 64200 country: Turkey name: Elif Gur Kabul role: CONTACT lat: 38.67351 lon: 29.4058 hasResults: False
nctId: NCT06302088 id: STUDY00026205 briefTitle: The Safety Integration Stakeholders (SAINTS) Program to Integrate Worker and Patient Safety in Oregon Rural Hospitals acronym: SAINTS overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2027-10 date: 2027-12 date: 2024-03-08 date: 2024-03-22 name: Oregon Health and Science University class: OTHER briefSummary: The safety integration stakeholders (saints) program to integrate worker and patient safety in Oregon rural hospitals. The rationale is that the saints program will positively impact outcomes by identifying and training peer leaders on strategies to optimize environmental, administrative, and educational components to become a saint and regularly collaborate with safety stakeholders/administrative leaders at each site through continuous improvement cycles (e.g. plan-do-study-act). conditions: Accidental Falls conditions: Injuries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: All participating clinics will take part in baseline surveys of unit staff (n=240-360) and safety stakeholders will be identified. Following surveys, hospitals will be randomized to the control arm (n=3) or the intervention arm (n=3). Both groups will engage in key informant interviews on safety culture (n=30-60). Control group hospitals will continue standard operating procedures. Intervention group hospitals will engage in social network analysis of surveys, have peer leaders identified, and engage in safety leadership training and quality improvement cycles. All hospitals regardless of arm will take part in 6-and-12-month surveys and 24-month interviews. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 240 type: ESTIMATED name: SAINTS program measure: Safety participation sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06302075 id: UKA-L2086 briefTitle: Functional Recovery After Medial Monocompartmental Knee Prosthesis: One Day Protocol Versus Fast Protocol acronym: UKA-L2086 overallStatus: RECRUITING date: 2021-11-16 date: 2024-12-31 date: 2025-12-01 date: 2024-03-08 date: 2024-03-12 name: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio class: OTHER briefSummary: The study is defined as prospective, randomized, interventional single-center; the general aim is to evaluate the post-operative recovery of the patient who carries out rehabilitation with the one day protocol (Group A), compared to the patient who carries out rehabilitation during the hospital stay with the fast protocol (group B). conditions: Gonarthrosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: One Day Rehabilitation name: Fast Rehabilitation measure: Knee Society Score (KSS) from 0 to 100 (whether higher scores mean a better outcome) sex: ALL minimumAge: 40 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istituto Clinico San Siro status: RECRUITING city: Milan state: Italia country: Italy name: Elena Cittera role: CONTACT phone: 0283502224 email: direzionescientifica.iog@grupposandonato.it name: Andrea Parente, MD role: PRINCIPAL_INVESTIGATOR lat: 45.46427 lon: 9.18951 hasResults: False