nctId: NCT06287138 id: KY2023-182-03 briefTitle: The Effect of Ciprofol on Breathing Patterns, Respiratory Drive, and Inspiratory Effort in Mechanically Ventilated Patients overallStatus: RECRUITING date: 2023-05-10 date: 2024-12-31 date: 2025-03-31 date: 2024-02-29 date: 2024-02-29 name: Capital Medical University class: OTHER briefSummary: Sedatives and analgesics are usually given for analgesic, anxiolytic, or sedating purposes for patients with critical illness, while they inevitably inhibit respiratory and circulatory function. Sometimes, patients receive deep sedation to induce hypoventilation or suppress spontaneous respiratory effort. The sedation level in clinical practice is usually assessed with subjective sedation scoring systems, such as the Richmond Agitation Sedation Scale (RASS). However, studies have found that sedation depth based on RASS is not a reliable marker of respiratory drive during critical illness. In recent years, researchers have proposed to monitor the effects of sedatives and analgesics on respiratory indicators and to implement lung-protective sedation, such as P0.1, Pocc, Pmus, WOB, and PTP. However, different pharmacological characteristics, different depths of sedation, and different sedation regimens among different sedatives and analgesics make a great difference in their effects on respiration. Ciprofol is an analog of propofol, with increased stereoselective effects adding to its anesthetic properties, is increasingly used in the intensive care unit, but its effects on respiration are not well understood. Therefore, this study aims to investigate the effects of ciprofol on respiratory patterns, respiratory drive, and inspiratory effort in mechanically ventilated patients. conditions: Mechanical Ventilation conditions: Sedation and Analgesia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: ciprofol measure: Explore the effect of ciprofol on tidal volume measure: Explore the effect of ciprofol on respiratory rate measure: Explore the effect of ciprofol on minute ventilation measure: Explore the effect of ciprofol on P0.1 measure: Explore the effect of ciprofol on PMI measure: Explore the effect of ciprofol on ΔPocc measure: Explore the effect of ciprofol on tidal volume measure: Explore the effect of ciprofol on respiratory rate measure: Explore the effect of ciprofol on minute ventilation measure: Explore the effect of ciprofol on P0.1 measure: Explore the effect of ciprofol on PMI measure: Explore the effect of ciprofol on ΔPocc measure: Explore the effect of ciprofol on systolic blood pressure measure: Explore the effect of ciprofol on diastolic blood pressure measure: Explore the effect of ciprofol on mean arterial pressure measure: Explore the effect of ciprofol on heart rate measure: Explore the effect of ciprofol on saturation of pulse oxygen measure: Explore the effect of ciprofol on end-tidal carbon dioxide pressure measure: Explore the effect of ciprofol on RASS score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beijing Tiantan Hospital status: RECRUITING city: Beijing state: Beijing zip: 100071 country: China name: Jian-Xin Zhou, MD role: CONTACT phone: 8610 59978019 email: zhoujx.cn@icloud.com name: Rui Su role: CONTACT phone: +8618611993866 email: surui1969@163.com lat: 39.9075 lon: 116.39723 hasResults: False