Since this study, the moesin gene has been integrated into DNA chips used for the molecular diagnosis of immune deficiencies in several countries. Physicians in Canada, the United States, Japan, South Africa and Europe have contacted us with a total of 16 known participants to date. Because of their very low severe, uncontrolled CMV infection and the absence of treatment recommendations, two 2 American participants were treated with allogeneic transplantation with severe post-transplant complications (1), and one of the participants died as a result of the transplant. Management of XMAID participants therefore varies widely from country to country, depending on age at diagnosis and clinical picture. It ranges from no treatment treatment (associated with recurrent infections and skin manifestations), IgIv substitution and/or antibiotic prophylaxis antibiotic prophylaxis, with low toxicity and apparent efficacy, and allogeneic transplantation, with all the risks risks involved (graft-related toxicity, graft versus host, disease, rejection, risk of infection). The Investigators therefore feel it is important to review the diagnosis, clinical presentation and management of X-MAID participants. The study the investigator propose will enable to understand the presentation of X-MAID participants, establish guidelines and provide the best treatment for each patient according to his or her clinical picture conditions: Immune Deficiency conditions: Autoimmune Diseases conditions: Infections conditions: Diagnosis studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: RETROSPECTIVE count: 16 type: ESTIMATED name: genetic restrospective study measure: The main objective measure: Secondary objectives1 measure: secondary objectives 2 measure: secondary objective 3 measure: secondary objectives 4 measure: secondary objective 5 sex: MALE minimumAge: 4 Years maximumAge: 80 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: National Institutes of Health status: NOT_YET_RECRUITING city: Bethesda state: Maryland zip: 20892 country: United States name: Luigi Notarangelo, Doctor role: CONTACT lat: 38.98067 lon: -77.10026 facility: Perelman School of medecine status: NOT_YET_RECRUITING city: Philadelphia state: Pennsylvania zip: 19050 country: United States name: Jennifer Heimall, Pr role: CONTACT lat: 39.95233 lon: -75.16379 facility: Brown University status: NOT_YET_RECRUITING city: Providence state: Rhode Island zip: 02912 country: United States name: Anthony Hayward role: CONTACT lat: 41.82399 lon: -71.41283 facility: Genomic Research Centre, School of Biomedical Sciences Institute of Health and Biomedical Innovation status: NOT_YET_RECRUITING city: Brisbane zip: 4001 country: Australia name: Lyn Griffith, Pr role: CONTACT lat: -27.46794 lon: 153.02809 facility: Hôpital Universitaire de la Reine Fabiola status: NOT_YET_RECRUITING city: Bruxelles zip: 1020 country: Belgium name: Catherine Heijmans, Doctor role: CONTACT lat: 50.85045 lon: 4.34878 facility: Hôpital Necker status: RECRUITING city: Paris zip: 75015 country: France name: Benedicte NEVEN role: CONTACT lat: 48.85341 lon: 2.3488 facility: CHU Rennes, CNRS UMR 629 status: RECRUITING city: Rennes zip: 35000 country: France name: Virginie Gandemer, Doctor role: CONTACT lat: 48.11198 lon: -1.67429 facility: CHU St Etienne Hôpital Nord status: NOT_YET_RECRUITING city: Saint-Étienne zip: 42270 country: France name: Jean-Louis STEPHAN, Doctor role: CONTACT lat: 45.43389 lon: 4.39 facility: Tokyo Medical and Dental University (TMDU) status: NOT_YET_RECRUITING city: Bunkyō-Ku zip: 1138510 country: Japan name: Kohsuke Imai, Pr role: CONTACT lat: 35.37517 lon: 139.92991 facility: Departments of Internal Medicine and Immunology status: NOT_YET_RECRUITING city: Rotterdam country: Netherlands name: Virgil Dalm role: CONTACT lat: 51.9225 lon: 4.47917 hasResults: False