hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06288165 id: CopperHealthCentre2 briefTitle: Lower Silesia Sinus Reducer Registry acronym: LSSRR overallStatus: RECRUITING date: 2022-05-11 date: 2027-05-11 date: 2027-05-11 date: 2024-03-01 date: 2024-03-01 name: Regional Cardiology Center, The Copper Health Centre (MCZ), class: OTHER briefSummary: Lower Silesia Sinus Reducer Registry is a , single-center, single-arm registry including patients with chronic disabling refractory angina pectoris (Canadian Cardiovascular Society \[CCS\] classes 2-4) despite maximally tolerated anti-angina medical therapy who underwent Coronary Sinus Reducer implantation . conditions: Safety Issues conditions: Efficacy, Self studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED name: Coronary Sinus Reducer Implantation measure: The Clinical success - reduction of angina symptoms measure: Incidence of Treatment-Emergent Adverse Events measure: Change in potential aerobic capacity and endurance - The six minute walking test (6MWT) measure: Reducing the severity of angina and it impact on quality of life, as shown by the Seattle Angina Questionnaire. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Cardiology, The Copper Health Centre (MCZ) status: RECRUITING city: Lubin state: Lower Silesia zip: 59-300 country: Poland name: Adrian Włodarczak, M.D; Ph.D.Assoc Prof. role: CONTACT phone: +48768460300 email: wlodarczak.adrian@gmail.com name: Szymon Włodarczak, MD role: CONTACT phone: +4876 846 03 00 email: wlodarczak.szy@gmail.com lat: 51.40089 lon: 16.20149 facility: Cardiac Department of Copper Health Center status: RECRUITING city: Lubin state: Lower Silesia zip: 59301 country: Poland name: Adrian Włodarczak, Prof role: CONTACT phone: 76 846 03 00 phoneExt: 0048 email: wlodarczak.adrian@gmail.com name: Szymon Włodarczak, MD role: CONTACT phone: 76 846 03 00 phoneExt: 0048 email: wlodarczak.szy@gmail.com name: Piotr Rola, Ph D; MD role: SUB_INVESTIGATOR lat: 51.40089 lon: 16.20149 hasResults: False
nctId: NCT06288152 id: STS-Transplant briefTitle: Evaluation of Thiosulfate Enhanced Organ Preservation Solution in Kidney Transplantation overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-03-01 date: 2027-03-01 date: 2024-03-01 date: 2024-03-01 name: Alp Sener class: OTHER briefSummary: End-stage renal disease (ESRD) is a significant clinical problem for which dialysis or transplantation is required. The current need for kidneys for transplantation vastly exceeds the supply available from live donors, necessitating the use of kidneys from deceased donors. However, kidneys from deceased donors are associated with reduced viability, as lack of blood supply upon cardiac death increases tissue damage. In addition, the standard protocol for cold preservation of donor kidneys between procurement and transplantation increases the risk of delayed donor kidney function by 23% for every 6-hours of storage. Moreover, compared to other organs, the kidney is particularly prone to transplantation-induced injury due to its high metabolic activities and oxygen consumption. Hence, any minor disturbances in blood supply can easily lead to kidney injury. Therefore, it is not surprising that deceased donor kidneys have a low tolerance for damage associated with lack of blood supply. The focus of the investigators research has been to pioneer the development and supplementation of existing kidney preservation solutions with novel hydrogen sulfide (H2S) donor molecules to improve kidney viability for clinical transplantation. Specifically, the investigators demonstrated that supplementation of standard kidney preservation solutions with non-clinically viable H2S donor molecules significantly increased donor kidney protection and prolonged transplant recipient survival in murine and porcine models of kidney transplantation. Having shown the same salutary effect using sodium thiosulfate (STS; a clinically viable H2S donor drug) in rat kidney transplantation, the investigators aim to repeat this work using STS in porcine and clinical kidney transplantation.
This single-blind study will enroll participants receiving a kidney transplant. Through randomization, half of the participants will receive STS through administration into the pump the kidney is placed on after procurement from the donor and before transplant to the recipient. Participants will be followed for 1-year post transplant where blood and urine will be collected to determine graft function. conditions: Renal Transplant conditions: Kidney Transplant studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: PARTICIPANT count: 120 type: ESTIMATED name: Sodium Thiosulfate measure: Effects of STS will be measured by: Delayed graft function sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06288139 id: open fracture tibia briefTitle: Management of Open Fracture Tibia in Teenagers overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-01-01 date: 2025-02-01 date: 2024-03-01 date: 2024-03-01 name: Assiut University class: OTHER briefSummary: The aim of this study is to study the incidence of open tibial fractures in early teenagers and evaluate the management outcomes conditions: Open tíbia Fracture studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 100 type: ESTIMATED measure: Number measure: To evaluate treatment outcomes measure: Soft tissue healing measure: Complication sex: ALL minimumAge: 10 Years maximumAge: 19 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06288126 id: MoMM-FET briefTitle: Maternal and Fetal Metabolic Changes acronym: MoMM-FET overallStatus: COMPLETED date: 2019-08-01 date: 2020-10-09 date: 2021-01-18 date: 2024-03-01 date: 2024-03-01 name: Azienda Ospedaliero, Universitaria Pisana class: OTHER briefSummary: The goal of this observational prospective project is to study the metabolic alterations during normal and complicated pregnancies, obtaining an early detection of metabolic changes, offering new insights into future prevention and treatment strategies for both mother and offspring.
The participants will be recruited during first trimester ultrasound after signing the informed consent. conditions: Pregnancy Related conditions: Maternal-Fetal Relations conditions: Metabolism Disorder, Glucose studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 457 type: ACTUAL measure: Blood adipokine levels measure: Abdominal Fat Thickness measure: Fetal Adipose Tissue Deposits measure: Gestational diabetes prevalence measure: Obstetric complications and mode of delivery sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Azienda Ospedaliera Universitaria Pisana city: Pisa zip: 56126 country: Italy lat: 43.70853 lon: 10.4036 hasResults: False
nctId: NCT06288113 id: 23-001509 id: NCI-2024-00310 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: 23-001509 type: OTHER domain: UCLA / Jonsson Comprehensive Cancer Center briefTitle: Re-treatment With 177Lu-PSMA-617 for the Treatment of Metastatic Castration-Resistant Prostate Cancer, RE-LuPSMA Trial overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-01-27 date: 2027-01-27 date: 2024-03-01 date: 2024-03-06 name: Jonsson Comprehensive Cancer Center class: OTHER name: Novartis Pharmaceuticals briefSummary: This phase II trial tests how well re-treatment with 177Lu-PSMA-617 works in treating patients with prostate cancer that has spread from where it first started (primary site) to other places in the body (metastatic), that continues to grow or spread after the surgical removal of the testes or medical treatment to block androgen production (castration-resistant), and that has shown a favorable response to initial treatment with 177Lu-PSMA-617. 177Lu-PSMA-617 is a radioactive drug. It binds to a protein called prostate specific membrane antigen (PSMA), which is expressed by some types of prostate tumor cells. When 177Lu-PSMA-617 binds to PSMA-expressing tumor cells, it delivers radiation to the cells, which may kill them. Re-treatment with 177Lu-PSMA-617 in patients who had a favorable response to initial 177Lu-PSMA-617 treatment may improve survival outcomes and disease response in patients with metastatic castration-resistant prostate cancer. conditions: Castration-Resistant Prostate Carcinoma conditions: Stage IVB Prostate Cancer AJCC v8 studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: Biospecimen Collection name: Computed Tomography name: Gallium Ga 68 Gozetotide name: Lutetium Lu 177 Vipivotide Tetraxetan name: Positron Emission Tomography name: Questionnaire Administration name: Single Photon Emission Computed Tomography measure: 12-month overall survival measure: Incidence of adverse events (AEs) measure: Rate of prostate specific antigen (PSA) response measure: Biochemical progression-free survival (PFS) measure: Overall Survival from start of first regimen measure: Overall survival from the end of the first regimen measure: Radiographic progression-free survival (rPFS) measure: Bone Pain measure: Changes in health-related quality of life_Functional Assessment of Cancer Therapy - Radionuclide Therapy (FACT-RNT). measure: Changes in health-related quality of life_Brief Pain Inventory Short form measure: Changes in health-related quality of life_ Eastern Cooperative Oncology Group score sex: MALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: UCLA / Jonsson Comprehensive Cancer Center city: Los Angeles state: California zip: 90095 country: United States name: Ethan Lam role: CONTACT phone: 310-206-7372 email: clam@mednet.ucla.edu name: Stephanie Lira role: CONTACT phone: 3102060596 email: StephanieLira@mednet.ucla.edu name: Jeremie Calais role: PRINCIPAL_INVESTIGATOR lat: 34.05223 lon: -118.24368 hasResults: False
nctId: NCT06288100 id: OWHTOPTS briefTitle: The Effect of Open Wedge High Tibial Osteotomy on the Posterior Tibial Slope In Skeletally Mature Patient overallStatus: COMPLETED date: 2023-01-01 date: 2023-12-31 date: 2024-01-01 date: 2024-03-01 date: 2024-03-01 name: Al-Azhar University class: OTHER briefSummary: High tibial osteotomy has been established as an efficient surgical intervention for young patients with uni-compartmental osteoarthritis of the knee. The principle of this surgery involves the realignment of the lower extremity to shift the load distribution from the medial compartment into the lateral compartment, thus leading to a decrease in symptoms related to medial compartment knee Osteoarthritis However, medial opening wedge high tibial osteotomy is also known to affect the posterior tibial slope angle , and it is reported that posterior tibial slope angle increases after medial opening wedge high tibial osteotomy . conditions: Genu Varum studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 40 type: ACTUAL name: Observation measure: The Effect of Open Wedge High Tibial Osteotomy on the Posterior Tibial Slope In Skeletally Mature Patient sex: ALL minimumAge: 20 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mohamed Abdelfattah Abbas city: Assiut country: Egypt lat: 27.18096 lon: 31.18368 hasResults: False
nctId: NCT06288087 id: 2023-20/672 briefTitle: Comparing Machine Guided VR Based Training With Educator Guided Training in Metaverse overallStatus: RECRUITING date: 2024-03-04 date: 2024-03-29 date: 2024-04-11 date: 2024-03-01 date: 2024-03-01 name: Acibadem University class: OTHER briefSummary: The main aim of this study is to compare the learning outcomes of machine guided VR based training for adult advanced life support with educator guided training in metaverse environment. conditions: Advanced Cardiac Life Support conditions: Virtual Reality conditions: Serious Game studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized Controlled Trial primaryPurpose: OTHER masking: SINGLE maskingDescription: the group trained with VR Based Training with Machine Guidance will be referred as MG group and the group trained with VR Based Training with Educators Guidance in Metaverse will be referred as EG group. whoMasked: PARTICIPANT count: 62 type: ESTIMATED name: VR Based Training with Machine Guidance (MG Group) name: VR Based Training with Educator Guidance in Metaverse (EG Group) measure: Comparing Learning outcome of the Advanced Cardiac Life Support Training of the two interventions used in this study sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Acibadem University CASE (Center of Advanced Simulation and Education) status: RECRUITING city: Istanbul state: Non-US/Canada zip: 34752 country: Turkey name: Dilek Kitapcioglu, Assist.Prof role: CONTACT phone: +905323636115 email: dilek.kitapcioglu@acibadem.edu.tr name: Mehmet Emin Aksoy, Assoc.Prof role: CONTACT phone: +905052685158 email: emin.aksoy@acibadem.edu.tr name: Dilek Kitapcioglu, Assist.Prof role: PRINCIPAL_INVESTIGATOR name: Mehmet Emin Aksoy, Assoc.Prof role: PRINCIPAL_INVESTIGATOR name: Arun Ekin Ozkan, M.Sc. role: SUB_INVESTIGATOR name: Tuba Usseli, M.Sc. role: SUB_INVESTIGATOR lat: 41.01384 lon: 28.94966 facility: Acibadem University CASE (Center of Advanced Simulation and Education) status: NOT_YET_RECRUITING city: Istanbul state: Non-US/Canada zip: 34752 country: Turkey name: Mehmet Emin Aksoy, Assoc.Prof role: CONTACT phone: +902165004201 email: emin.aksoy@acibadem.edu.tr name: Dilek Kitapcioglu, Ph.D. role: CONTACT phone: +2165004202 phoneExt: Aksoy email: dilek.kitapcioglu@acibadem.edu.tr name: Dilek Kitapcioglu, MD, Ph.D. role: PRINCIPAL_INVESTIGATOR name: Mehmet Emin Aksoy, MD, Ph.D. role: PRINCIPAL_INVESTIGATOR name: Arun Ekin Ozkan, M.Sc. role: SUB_INVESTIGATOR name: Tuba Usseli, M.S role: SUB_INVESTIGATOR lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06288074 id: SF-2022-1-1061 briefTitle: Diagnosis and Treatment Strategy Optimization of Severe Pneumonia Based on Multi-omics Data Integration overallStatus: RECRUITING date: 2024-03-10 date: 2024-12-31 date: 2024-12-31 date: 2024-03-01 date: 2024-03-01 name: Capital Medical University class: OTHER briefSummary: Severe community-acquired pneumonia still has a high incidence and mortality, but the molecular mechanism and prognostic biomarkers of severe community-acquired pneumonia caused by different pathogens are still unclear, and the best treatment strategy has not been determined. Based on this, this project intends to take patients with severe community-acquired pneumonia caused by different pathogens as the research object, explore the molecular mechanism of severe community-acquired pneumonia from multiple angles, integrate relevant research data to evaluate the rationality of initial empirical medication, and lay the foundation for precise treatment of severe pneumonia. The research results will help to develop a new rapid and accurate target for clinical diagnosis and efficacy evaluation of severe pneumonia, and build a precise treatment system for severe pneumonia. conditions: Severe Community-acquired Pneumonia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 300 type: ESTIMATED name: Multi-omics tests measure: Hospital mortality measure: Cause of death measure: Length of stay measure: Length of ICU stay measure: Expense during hospitalization sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beijing Institute of Respiratory Medicine status: RECRUITING city: Beijing state: Beijing zip: 100027 country: China name: Zhaohui Tong, Dr role: CONTACT phone: +86 010 8523 1000 email: 13910930309@163.com lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06288061 id: Phrenic Nerve Neuromodulation briefTitle: Effectiveness of Non-invasive Phrenic Nerve Neuromodulation in Subjects With Inflammatory Bowel Disease and Neck Pain. overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2025-06-06 date: 2025-07-04 date: 2024-03-01 date: 2024-03-05 name: University of Seville class: OTHER briefSummary: Inflammatory bowel diseases (IBD) are chronic relapsing diseases that generate an autoimmune response against the bowel and its microbiota. Its prevalence is increasing worldwide. These include Ulcerative Colitis (UC) and Crohn's Disease(CD).
The Phrenic nerve originates at the roots C3-C4-C5 carrying motor and sensory information. Directly or through connections it innervates the diaphragm, pleura, right atrium, pericardium, oesophagus, peritoneum, stomach, falciform and coronary ligaments of the liver, Glisson's capsule, hepatic and inferior vena cava, liver (parenchyma), gallbladder and the rest of the biliary tract, pancreas, small intestine and adrenal glands. It also has fibres of the autonomic nervous system.
Non-invasive Phrenic nerve neuromodulation in subjects suffering from inflammatory bowel disease and neck pain will improve their quality of live, disability and sensitisation, as well as neck pain and mobility. conditions: Inflammatory Bowel Diseases conditions: Neck Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 68 type: ESTIMATED name: Non-invasive Neuromodulation name: Cervico-dorsal Massage measure: The Visual Analogue Scale (VAS) measure: Cervical mobility measure: The Neck Disability Index (NDI) measure: The Pressure Pain Threshold (PPT) measure: The Inflammatory Bowel Disease Questionnaire (IBDQ-32) measure: The World Health Organization Quality of Life (WHOQOL-BREF) measure: The Central Sensitization Inventory (CSI) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hospital Universitario Puerto Real city: Puerto Real state: Cádiz zip: 11510 country: Spain lat: 36.52819 lon: -6.19011 hasResults: False
nctId: NCT06288048 id: 23/107-EC X TFM 07/03/2023 briefTitle: Effect of Mirror Therapy on Post-Needling Pain Following Deep Dry Needling of Myofascial Trigger Point in Lateral Elbow Pain overallStatus: ACTIVE_NOT_RECRUITING date: 2023-04-01 date: 2024-03-07 date: 2024-06-30 date: 2024-03-01 date: 2024-03-01 name: Universidad Europea de Canarias class: OTHER briefSummary: The goal of this randomized, controlled pilot trial is to investigate the immediate effects of incorporating Mirror Visual Feedback Therapy (MFT) on pain sensitivity and motor performance in individuals experiencing Post-needling pain associated with lateral elbow pain. The main questions it aims to answer are:
Researchers will compare the Experimental Group to the Control Group to see if the incorporation of Mirror Visual Feedback Therapy results in a reduction in Post-needling pain intensity and improvement in pressure pain threshold. conditions: Lateral Elbow Pain studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: Allocation and data assessor were blinded. whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 49 type: ESTIMATED name: Experimental: Deep Dry Needling (DDN), Ischemic Compression, Cold Spray with Stretching + MFT name: Deep Dry Needling (DDN), Ischemic Compression, Cold Spray with Stretching measure: Pain Intensity measure: Pain pressure threshold measure: Two-point discrimination threshold measure: Maximum hand grip strength sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Universidad Europea de Canarias city: La Orotava state: Santa Cruz De Tenerife zip: 38300 country: Spain lat: 28.39076 lon: -16.52309 hasResults: False
nctId: NCT06288035 id: R.21.02.1191 briefTitle: Oral Dexamethasone for Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy overallStatus: RECRUITING date: 2024-03-04 date: 2025-03 date: 2025-03 date: 2024-03-01 date: 2024-03-12 name: Mansoura University class: OTHER briefSummary: Postoperative nausea and vomiting (PONV) are common complications after laparoscopic cholecystectomy. This study aims to evaluate the efficacy of the administration of prophylactic oral dexamethasone at night before surgery in preventing PONV after elective laparoscopic cholecystectomy. conditions: Postoperative Nausea and Vomiting studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a parallel, two-arm, randomized (1:1), controlled, single-center non-inferiority trial. Adults (≥18 years) with ASA physical status I-III scheduled for elective laparoscopic cholecystectomy will be eligible for inclusion. The participants will be randomized to receive either 8 mg of IV Dexamethasone at the time of induction of anesthesia or 8 mg of oral Dexamethasone at night before surgery. The primary outcome will be the incidence of postoperative nausea and vomiting. 814 patients are intended to be recruited for this non-inferiority trial. primaryPurpose: PREVENTION masking: SINGLE maskingDescription: The outcome assessors will be blinded to the group allocation. whoMasked: OUTCOMES_ASSESSOR count: 814 type: ESTIMATED name: Dexamethasone Oral name: Dexamethasone measure: Postoperative nausea or vomiting (PONV) measure: Rescue antiemetic measure: Early PONV measure: Late PONV measure: Visual Analogue Scale (VAS) at the time of discharge from PACU measure: VAS at the time of discharge from hospital measure: Postoperative fatigue measure: Postoperative quality of recovery measure: Post-Discharge Nausea and Vomiting (PDNV) measure: Surgical Site Infection (at follow-up) measure: Itching or burning sensation on dexamethasone injections sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mansoura University Faculty of Medicine status: RECRUITING city: Mansoura state: Aldakahlia zip: 35516 country: Egypt name: Moataz M Emara, MD, EDAIC role: CONTACT phone: 01064048848 email: mm.emara@mans.edu.eg lat: 31.03637 lon: 31.38069 hasResults: False
nctId: NCT06288022 id: COA. MURA2023/947 briefTitle: Comparison of Total Tubeless Mini-PCNL Versus Tubeless Mini-PCNL overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-30 date: 2026-06-30 date: 2024-03-01 date: 2024-03-07 name: Mahidol University class: OTHER briefSummary: Limited literature has focused on the use of totally tubeless mini-percutaneous nephrolithotomy (Mini-PCNL) for the treatment of large renal stones.
Patients will not be informed of the treatment intervention in advance whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 130 type: ESTIMATED name: total tubeless mini-PCNL name: tubeless mini-PCNL measure: incidence of complications between total tubeless mini-pcnl and tubeless mini-PCNL measure: The secondary objective is to assess the surgical outcomes between total tubeless mini-pcnl and tubeless mini-PCNL sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ramathibodi Hospital, Mahidol University city: Bangkok state: Ratchathewi zip: 10400 country: Thailand name: Thanakorn Sirajarus role: CONTACT phone: 086-599-3259 email: Thanakorn.sjr@gmail.com name: Chinnakhet Ketsuwan role: CONTACT phone: 086-345-6901 email: chinnakhet.ket@mahidol.ac.th lat: 13.75398 lon: 100.50144 hasResults: False