hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06347627 id: UW23139 briefTitle: Communicating Human Papillomavirus Vaccine With Japanese Parents and Caregivers With Daughters Aged 12-18 overallStatus: ENROLLING_BY_INVITATION date: 2023-12-22 date: 2024-12 date: 2024-12 date: 2024-04-04 date: 2024-04-04 name: The University of Hong Kong class: OTHER name: London School of Hygiene and Tropical Medicine name: Nagasaki University briefSummary: This study aims to comprehensively assess confidence in and acceptance of human papillomavirus (HPV) vaccines among Japanese parents and caregivers with daughters aged 12-18 and their decision-making process. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 1600 type: ESTIMATED name: Group 1 (I x S x S x F) name: Group 2 (O x S x S x F) name: Group 3 (I x E x S x F) name: Group 4 (O x E x S x F) name: Group 5 (I x S x S x M) name: Group 6 (O x S x S x M) name: Group 7 (I x E x S x M) name: Group 8 (O x E x S x M) name: Group 9 (I x S x D x F) name: Group 10 (O x S x D x F) name: Group 11 (I x E x D x F) name: Group 12 (O x E x D x F) name: Group 13 (I x S x D x M) name: Group 14 (O x S x D x M) name: Group 15 (I x E x D x M) name: Group 16 (O x E x D x M) measure: Willingness to receive HPV vaccines for daughters measure: Confidence in HPV vaccine safety sex: FEMALE minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT facility: London School of Hygiene and Tropical Medicine city: London country: United Kingdom lat: 51.50853 lon: -0.12574 hasResults: False
nctId: NCT06347614 id: 2021-FXY-042 briefTitle: Modified Radical Prostatectomy for Prostate Cancer Patients With Enlarged Prostate and Severe Lower Urinary Tract Symptoms: a Single-center, Retrospective Study acronym: Two-step RP overallStatus: ACTIVE_NOT_RECRUITING date: 2021-09-01 date: 2024-12-01 date: 2024-12-31 date: 2024-04-04 date: 2024-04-04 name: Sun Yat-sen University class: OTHER briefSummary: The goal of this retrospective, observational study is to preliminarily learn about the safety and efficacy of two-step radical prostatectomy in the treatment of low- to intermediate-risk prostate cancer patients with enlarged prostate and severe benign prostatic hyperplasia. The main questions it aims to answer are: 1. Whether two-step prostatectomy is safe enough to decrease the surgical difficulty of these patients? 2. Whether the oncologic control is promising? conditions: Prostate Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 30 type: ESTIMATED name: Two-step Radical Prostatectomy measure: Biochemical Recurrence-free Survival measure: Surgical time measure: Estimated blood loss measure: Hospital stay measure: Continence ContinenceContinence Continence Continence Continence Continence Continence Continence Continence measure: Lower urinary tract symptoms measure: Erectile function measure: Positive surgical margin rate measure: Complication sex: MALE stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Sun Yat-sen University Cancer Center city: Guangzhou state: Guangdong zip: 510060 country: China lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06347601 id: 2024-03-011AC briefTitle: Survey on Sexual and Gender in the Healthcare in Taiwan overallStatus: RECRUITING date: 2024-03-13 date: 2025-02-01 date: 2025-02-20 date: 2024-04-04 date: 2024-04-29 name: Taipei Veterans General Hospital, Taiwan class: OTHER_GOV briefSummary: This study addresses the pervasive issue of sexual harassment within Taiwanese society, particularly within the medical field, where comprehensive research is lacking. The research objective is to explore patterns of sexual harassment and gender discrimination experiences among physicians and medical students in Taiwan, while also investigating potential associations with professional burnout and mental health. Employing a convergent mixed-methods design, the study combines quantitative surveys and qualitative in-depth interviews. While lacking a control group and utilizing non-blinding methods without random assignment, the study aims to recruit 1000 participants aged 18 or older, considering both valid responses and potential dropouts. Additionally, interviews will be conducted with 30 individuals who have experienced sexual harassment or are interested in gender issues. The research methods will assess sexual harassment experiences, professional burnout, and depressive symptoms as primary outcomes or indicators. conditions: Sexual Harassment studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 1000 type: ESTIMATED name: Without Intervention measure: Center for Epidemiologic Studies Depression Scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Taipei Veterans General Hospital status: RECRUITING city: Taipei zip: 100 country: Taiwan name: Jheng-Min Yu, M.D. role: CONTACT phone: 0933238592 email: TaipeiDU2017@gmail.com lat: 25.04776 lon: 121.53185 hasResults: False
nctId: NCT06347588 id: OBI&ICI briefTitle: Risk of Reactivation of Occult Hepatitis B in Cancer Patients During Immunotherapy. overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-05 date: 2026-12 date: 2024-04-04 date: 2024-04-05 name: Fondazione IRCCS Policlinico San Matteo di Pavia class: OTHER briefSummary: The goal of this observational study is to evalue the cumulative proportion of patients with OBI who do not develop HBsAg seroreversion and/or an increase of serum HBV DNA by at least 1 log above the lower limit of detection of the assay in a patient who had previously undetectable HBsAg and HBV DNA in serum during the study. conditions: Occult Hepatitis B Infection in Cancer Patients studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: Observational: Blood sample of HVB-specific Elispot assay, HBSAg, HBV-DNA measure: To evaluate the cumulative proportion of patients with OBI who do not develop one seroreversion of HBsAg and/or an increase in serum HBV DNA of at least 1 log above the lower limit of detection of the test in a patient who had previously HBsAg and HBV measure: Evaluation of the incidence of reactivation in patients during immunotherapy measure: Evaluation of the association between HBV-specific T-cell response and HBV reactivation measure: Analysis of the incidence of reactivation of HBV in patients with p-OBI according to tumor characteristics (histology and stage) and type and line of treatment (immunotherapy, combined treatment with chemotherapy + immunotherapy). sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Irccs San Matteo Pavia city: Pavia state: PV zip: 27100 country: Italy name: Alessandra Ferrari role: CONTACT phone: 0382.503689 email: alessandra.ferrari@smatteo.pv.it name: ANGIOLETTA LASAGNA role: PRINCIPAL_INVESTIGATOR lat: 45.19205 lon: 9.15917 hasResults: False
nctId: NCT06347575 id: APHP230522 briefTitle: Safety and Tolerability of a Novel Implantable Neurostimulator for Ameliorate Erectile Function on Spinal Cord Injured Patients acronym: CAVERSTIM overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-11 date: 2025-11 date: 2024-04-04 date: 2024-04-04 name: Assistance Publique - Hôpitaux de Paris class: OTHER name: Comphya SA briefSummary: The main objective of the study is to assess the safety and tolerability of cavernous nerve electrical stimulation in patients with spinal cord injured (SCI) by assessing and measuring complications.
In addition, the study aims to refine the method of implantation (step-by-step delineation of all technical approaches for device implantation, including duration of surgical procedure, blood loss, methods to access the periprostatic region, tissue dissection, device placement and fixation) prior to planning for larger scale clinical investigation. conditions: Spinal Cord Injuries conditions: Erectile Dysfunction studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Implantation of the caverStim device measure: Safety evaluation measure: Pain assessement measure: Complications related to implantation surgery measure: Evaluation of IIEF-EF measure: Evaluation of EHS measure: Evaluation of SEP measure: Evaluation of GAQ sex: MALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Department of neurology-urology-andrology, Raymond Poincaré hospital - APHP city: Garches zip: 92380 country: France lat: 48.84226 lon: 2.18232 facility: Department of Urology, La pitié Salpêtrière Hospital - APHP city: Paris zip: 75013 country: France lat: 48.85341 lon: 2.3488 hasResults: False
nctId: NCT06347562 id: 934 briefTitle: Optical Genome Mapping for the Diagnosis of Neurodevelopmental Disorders overallStatus: RECRUITING date: 2022-06-15 date: 2025-06-14 date: 2025-06-14 date: 2024-04-04 date: 2024-04-04 name: IRCCS Eugenio Medea class: OTHER briefSummary: to evaluate the ability of the Optical genome Mapping (OGM) approach to detect simple and complex constitutional chromosomal aberrations of clinical relevance, which had previously been identified with standard diagnostic approaches (karyotyping, FISH, CNV-microarray) in the context of neurodevelopmental disorders (NDDs) with/wo congenital anomalies (CA) conditions: Neurodevelopmental Disorder (Diagnosis) studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 58 type: ESTIMATED name: Optical Genome Mapping measure: Diagnostic concordance rate sex: ALL minimumAge: 2 Years maximumAge: 17 Years stdAges: CHILD facility: Scientific Institute E. Medea status: RECRUITING city: Bosisio Parini state: Lecco zip: 23842 country: Italy name: Clara Bonaglia, PhD role: CONTACT phone: 031877913 phoneExt: +39 email: clara.bonaglia@lanostrafamiglia.it lat: 45.80075 lon: 9.29 hasResults: False
nctId: NCT06347549 id: HE-SF2024/09 briefTitle: The Impact of Diaphragmatic Breathing Instructions and Inspiratory Pressures on Diaphragm Contraction in Healthy Adults overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-04-15 date: 2026-04-15 date: 2024-04-04 date: 2024-04-04 name: Hong Kong Metropolitan University class: OTHER briefSummary: This is a cross-sectional obsessional study.
Participants will be asked to breathe through a pressure threshold inspiratory loading device under different inspiratory resistances with and without a standard diaphragmatic breathing instruction. sternocleidomastoid muscle activity will be measured with surface electromyography, and diaphragm thickness will be assessed with ultrasonography. conditions: Diaphragm studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 36 type: ESTIMATED name: Various intensities of inspiratory muscle training measure: Diaphragmatic thickening fraction measure: Muscle activation of the sternocleidomastoid muscle measure: Perceived Exertion Borg scale sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2024-03-25 uploadDate: 2024-03-28T00:38 filename: Prot_SAP_000.pdf size: 185477 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-03-25 uploadDate: 2024-03-28T00:39 filename: ICF_001.pdf size: 204027 hasResults: False
nctId: NCT06347536 id: IRAS331831 id: NIHR156698 type: OTHER_GRANT domain: NIHR HTA briefTitle: Supported Rescue Packs Post-discharge in Chronic Obstructive Pulmonary Disease acronym: RAPID overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-12-31 date: 2027-12-31 date: 2024-04-04 date: 2024-04-19 name: Guy's and St Thomas' NHS Foundation Trust class: OTHER name: King's College London name: University College, London name: Imperial College London name: University of Cambridge name: University of Southampton name: University of Nottingham name: University of Leicester name: Frimley Health NHS Foundation Trust name: Newcastle University name: University of Bristol name: Asthma and Lung UK briefSummary: Chronic obstructive pulmonary disease (COPD) is a chronic lung disease affecting approximately 10% of the adult population globally. COPD is recognised to be an important area of focus, as part of one of the healthcare challenges defined by the Office of Life Sciences. Patients with COPD often experience exacerbations which are triggered episodes leading to disease worsening. Exacerbations are associated with increased morbidity and a risk of mortality.
Severe exacerbations, where patients are hospitalised, are of particular concern to patients, carers and healthcare givers. The National Institute for Health and Care Excellence (NICE) recommends that hospital clinicians looking after patients with COPD should provide rescue packs (a course of prednisolone and antibiotics) and a basic management plan to patients on discharge. It is recognised that there is a high-risk 90-day period to patients with COPD following discharge from hospital, where there is a 43% risk of readmission and a 12% risk of mortality; however repeated national audit data has shown that, despite NICE recommendations this high risk of readmission and mortality has not changed.
nctId: NCT06347523 id: FirstShantou briefTitle: VR-Based Preoperative Rehabilitation Program for Patients Undergoing Anterior Cruciate Ligament (ACL) Reconstruction overallStatus: RECRUITING date: 2024-04-02 date: 2024-10-01 date: 2024-12-31 date: 2024-04-04 date: 2024-04-04 name: First Affiliated Hospital of Shantou University Medical College class: OTHER briefSummary: Between April 2, 2024, and October 1, 2024, a study will be conducted at the Department of Orthopedics in the First Affiliated Hospital of Shantou University Medical College involving 120 patients who will undergo anterior cruciate ligament reconstruction surgery. They will be randomly divided into two groups: an experimental group and a control group. conditions: Anterior Cruciate Ligament (ACL) Reconstruction conditions: Preoperative Rehabilitation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: The VR-based preoperative rehabilitation program; name: standard nursing care, measure: knee joint range of motion measure: Lysholm knee function score measure: SAS self-rating anxiety scale scale measure: SDS self-rating depression scale scale measure: Visual Analog Scale pain score measure: Barthel Index for basic activities of daily living measure: time to first ambulation post-surgery measure: postoperative complications measure: nursing satisfaction sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: "The First Affiliated Hospital of Shantou University Medical College status: RECRUITING city: Shantou state: Guangdong zip: 515000 country: China name: Zeshan Chen role: CONTACT phone: +8613592896271 lat: 23.36814 lon: 116.71479 hasResults: False
nctId: NCT06347510 id: E-25403353-050.99-174660 briefTitle: The Level of sST2 in Pediatric Heart Failure overallStatus: COMPLETED date: 2021-08-16 date: 2024-02-16 date: 2024-02-16 date: 2024-04-04 date: 2024-04-04 name: Eskisehir Osmangazi University class: OTHER briefSummary: Introduction: Suppression of tumorigenicity 2 (ST2) is a receptor member belongs to the Interleukin-1 (IL-1) family. The ligand and soluble versions are its two isoforms. The interleukin-33-ST2 ligand complexs development provides protection against heart fibrosis and hypertrophy. Investigations on heart failure in adults has demonstrated that it does not change by age, body mass index (BMI), creatinine, hemoglobin, and albumin levels, in contrast to NT pro brain natriuretric peptit. In adult heart failure patients, it has been demonstrated to be an independent predictor of mortality and cardiovascular events. The most recent guideline recommends using it as class 2b in the diagnosis of adult heart failure. Studies on ST2 in children are rare. The purpose of this study is to assess the prognostic value of ST2 for cardiovascular events in young individuals suffering from heart failure.
Method: The study included pediatric patients (0-18 years old) with congenital heart disease or cardiomyopathy who needed medical care as well as surgical or interventional treatment. Height, weight, gender, saturation, heart failure classification (Ross or New York heart Assosiation), medications taken, the electrocardiogram, echocardiography, Pro BNP, and sST2 values of the patients, as well as any hospitalization, lower respiratory tract infection, organ dysfunction, or need for angiography or surgery during follow-up Data on arrhythmia and death were gathered during a 1-year follow-up. The SPSS software application was used to carry out the statistical analysis. conditions: Congenital Heart Disease conditions: Congestive Heart Failure studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 59 type: ACTUAL name: Suppression of tumorigenicity 2 (ST2) measure: Soluble suppression of tumorigenicity levels with or without major cardiovascular event measure: Pro BNP levels measure: Major cardiovascular event ( such as hospitalization, lower respiratory tract infection, organ dysfunction, or need for angiography or surgery) sex: ALL minimumAge: 1 Month maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Eskisehir Osmangazi University city: Eskisehir state: Odunpazarı zip: 26040 country: Turkey lat: 39.77667 lon: 30.52056 hasResults: False
nctId: NCT06347497 id: 000001230988 briefTitle: Zonisamide Versus Topiramate in Migraine overallStatus: RECRUITING date: 2024-04-01 date: 2025-04-02 date: 2025-05-01 date: 2024-04-04 date: 2024-04-24 name: Kafrelsheikh University class: OTHER briefSummary: Investigators aim to compare the effect of zonisamide versus topiramate in migraine by assessing the absolute reduction in MMD in each group, the percentage of patients who achieved ≥ 50% reduction in the monthly headache days frequency compared to the baseline frequency conditions: Migraine studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: We will assess The number of migraine days after three months of treatment, and the percentage of patients who achieved ≥ 50% reduction in the monthly headache days frequency compared to the baseline frequency. HIT-6 score reduction in each group after three months of treatment. The safety of lacosamide was evaluated by monitoring and documenting treatment-emergent adverse events (TEAE) in patients through regular follow-up procedures for three months. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: An independent statistician generated a blocked randomization sequence using computer-generated random numbers; participants received either zonisamide and acetaminophen or topiramate and acetaminophen from a specially trained and qualified nurse. We prepared Sequentially numbered opaque sealed envelopes and 600 labels for each drug labeled Drug A or B. According to the randomization chart, put them into envelopes numbered 1 to 600. Envelopes were attached to the patient's files. Patients were recruited sequentially and were given enrollment numbers starting from 1, which were mentioned in their files. Files with the same number as the patient enrolment number were opened and the patients were assigned to receive drugs A or B. Drug A included zonisamide and acetaminophen, and Drug B included topiramate and acetaminophen. The statistical analysis was performed by an independent statistician who did not know the treatment protocol of groups A or B whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 600 type: ESTIMATED name: Zonisamide 50 MG name: Topiramate 50 MG measure: The change in migraine days per 28 days measure: The total number of migraine days after three months of treatment measure: The percentage of patients who achieved ≥ 50% reduction in the monthly migraine days frequency compared to the baseline frequency. measure: HIT-6 score absolute reduction in each group after three months of treatment measure: The safety of lacosamide was evaluated by monitoring treatment-emergent adverse events (TEAE) for three months. sex: ALL minimumAge: 10 Years maximumAge: 55 Years stdAges: CHILD stdAges: ADULT facility: Kafr Elsheikh University Hospital status: RECRUITING city: Kafr Ash Shaykh zip: 33511 country: Egypt name: mohamed G. Zeinhom, MD role: CONTACT phone: 2001009606828 email: mohamed_gomaa@med.kfs.edu.eg lat: 31.11174 lon: 30.93991 hasResults: False
nctId: NCT06347484 id: IRB00411716 briefTitle: Developing a Learning COmmunity to Increase eNgagemeNt and Enrollment in Cardiovascular Clinical Trials (CONNECT) acronym: CONNECT overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-12 date: 2026-10 date: 2024-04-04 date: 2024-04-04 name: Johns Hopkins University class: OTHER name: Morgan State University name: American Heart Association briefSummary: The CONNECT: "Developing a learning COmmunity to increase eNgagemeNt and Enrollment in cardiovascular Clinical Trials" is comprehensive, participant-centered learning community that provides tailored education on cardiovascular (CV) health and research participation; connects community members to CV-related research; and disseminates CV-related study findings. The overreaching goal of CONNECT is to improve participation of underrepresented communities in CV research, including as women, Black adults, and Latino adults, through increasing participants' clinical trial awareness, trust in biomedical research, and willingness to participate in clinical trials. CONNECT will use digital and community-engaged approaches to identify and recruit 1000 adults with cardiovascular disease or a cardiovascular disease risk factor to join CONNECT. Participants who join CONNECT will receive tailored educational information on CV health and research participation via text message. Participants will also have the opportunity to be matched to ongoing CV research studies based on basic demographic information and areas of interest. The educational information will be sent to participants for 12 months. The investigators hypothesize that CONNECT will increase participants' clinical trial awareness, trust, and willingness to participate in clinical trials and that the proportion of Black and Latin adults and women enrolled in trials that partner with CONNECT will be higher following the use of CONNECT for recruitment. conditions: Cardiovascular Diseases conditions: Hypertension conditions: Diabetes Type 2 conditions: Stroke conditions: Recruitment conditions: Overweight and Obesity conditions: Hyperlipidemias studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 1000 type: ESTIMATED name: Formal Toned Educational Messages name: Understanding Toned Educational Messages name: Casual Toned Educational Messages measure: Participant accrual measure: Participant accrual in partnering cardiovascular research studies measure: Trust in Biomedical Research using the Perceptions of Research Trustworthiness Scale (PoRT) measure: Clinical trials awareness and knowledge will be assessed using items adapted from the Health Information National Trends Survey (HINTS) measure: Willingness to participate in research will be measured by asking participants one related question sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False