nctId: NCT06267001 id: GO45006 id: 2023-506696-10-00 type: REGISTRY domain: EU CT briefTitle: A Study of Tiragolumab Plus Atezolizumab Compared With Placebo Plus Atezolizumab in Participants With Completely Resected Non-small Cell Lung Cancer Who Have Received Adjuvant Platinum-based Chemotherapy acronym: SKYSCRAPER-15 overallStatus: RECRUITING date: 2024-03-21 date: 2034-03-31 date: 2039-06-30 date: 2024-02-20 date: 2024-04-26 name: Hoffmann-La Roche class: INDUSTRY briefSummary: The purpose of this study is to evaluate the efficacy and safety of tiragolumab plus atezolizumab compared with placebo plus atezolizumab administered to participants with non-small cell lung cancer (NSCLC) following resection and adjuvant chemotherapy. conditions: Non-small Cell Lung Cancer (NSCLC) studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 1150 type: ESTIMATED name: Atezolizumab name: Tiragolumab name: Placebo measure: Disease-free Survival (DFS) measure: Percentage of Participants With Adverse Events (AEs) measure: Overall Survival (OS) measure: DFS Rate measure: Percentage of Participants Who Maintained or Meaningfully Improved from Baseline in Patient-reported Role, Emotional, and Physical Functioning and Global Health Status (GHS)/Quality of Life (QoL) measure: Serum Concentration of Tiragolumab measure: Serum Concentration of Atezolizumab measure: Percentage of Participants With Anti-Drug Antibodies (ADAs) to Tiragolumab measure: Percentage of Participants With ADAs to Atezolizumab sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Oncology Institute of Hope and Innovation; Cerritos status: RECRUITING city: Cerritos state: California zip: 90703 country: United States lat: 33.85835 lon: -118.06479 facility: University of California, San Francisco; Medical Center status: RECRUITING city: San Francisco state: California zip: 94158 country: United States lat: 37.77493 lon: -122.41942 facility: Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital status: RECRUITING city: Marietta state: Georgia zip: 30060 country: United States lat: 33.9526 lon: -84.54993 facility: Springfield Clinic status: RECRUITING city: Springfield state: Illinois zip: 62702 country: United States lat: 39.80172 lon: -89.64371 facility: UNM Lovelace status: RECRUITING city: Albuquerque state: New Mexico zip: 87102 country: United States lat: 35.08449 lon: -106.65114 facility: University of New Mexico Cancer Center status: RECRUITING city: Albuquerque state: New Mexico zip: 87106 country: United States lat: 35.08449 lon: -106.65114 facility: Asante Rogue Regional Medical Center status: RECRUITING city: Medford state: Oregon zip: 97504-8332 country: United States lat: 42.32652 lon: -122.87559 facility: Hospital Britanico; Oncologia status: RECRUITING city: Buenos Aires zip: C1280AEB country: Argentina lat: -34.61315 lon: -58.37723 facility: Centro Oncologico Korben; Oncology status: RECRUITING city: Ciudad Autonoma Buenos Aires zip: C1426AGE country: Argentina lat: -34.61315 lon: -58.37723 facility: CINME S.A. ? Centro de Investigaciones Metabolicas - Rx Trials LLC status: RECRUITING city: Ciudad Autonoma de Buenos Aires zip: C1027AAP country: Argentina lat: -34.61315 lon: -58.37723 facility: Sunshine Coast University Hospital; The Adem Crosby Centre status: RECRUITING city: Birtinya state: Queensland zip: 4575 country: Australia lat: -26.74322 lon: 153.11913 facility: Greenslopes Private Hospital; Gallipoli Research Centre status: RECRUITING city: Greenslopes state: Queensland zip: 4120 country: Australia lat: -27.50815 lon: 153.04951 facility: Cancer Research SA status: RECRUITING city: Adelaide state: South Australia zip: 5000 country: Australia lat: -34.92866 lon: 138.59863 facility: Monash Health status: RECRUITING city: Clayton state: Victoria zip: 3168 country: Australia lat: -37.91667 lon: 145.11667 facility: Hospital de Cancer de Barretos status: RECRUITING city: Barretos state: SP zip: 14784-400 country: Brazil lat: -20.55722 lon: -48.56778 facility: Hospital A. C. Camargo; Oncologia status: RECRUITING city: Sao Paulo state: SP zip: 01509-010 country: Brazil lat: -23.5475 lon: -46.63611 facility: Changzhou First People's Hospital; Oncology status: RECRUITING city: Changzhou zip: 213003 country: China lat: 31.77359 lon: 119.95401 facility: The First Affiliated Hospital of Sun Yat-sen University status: RECRUITING city: Guangzhou City zip: 510080 country: China facility: Guangdong General Hospital status: RECRUITING city: Guangzhou zip: 510080 country: China lat: 23.11667 lon: 113.25 facility: Shandong Cancer Hospital status: RECRUITING city: Jinan zip: 250117 country: China lat: 36.66833 lon: 116.99722 facility: Yunnan Cancer Hospital status: RECRUITING city: Kunming zip: 650118 country: China lat: 25.03889 lon: 102.71833 facility: The First Affiliated Hospital of Nanchang University status: RECRUITING city: Nanchang City zip: 330008 country: China facility: Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School status: RECRUITING city: Nanjing City zip: 210008 country: China facility: Ningbo No.2 Hospital status: RECRUITING city: Ningbo country: China lat: 29.87819 lon: 121.54945 facility: Zhongshan Hospital Fudan University status: RECRUITING city: Shanghai zip: 200032 country: China lat: 31.22222 lon: 121.45806 facility: Shanghai Pulmonary Hospital status: RECRUITING city: Shanghai zip: 200433 country: China lat: 31.22222 lon: 121.45806 facility: Liaoning Provincial Cancer Hospital status: RECRUITING city: Shengyang zip: 110042 country: China facility: Tianjin Cancer Hospital status: RECRUITING city: Tianjin zip: 300060 country: China lat: 39.14222 lon: 117.17667 facility: Tongji Hospital Tongji Medical College Huazhong University of Science and Technology status: RECRUITING city: Wuhan City zip: 430030 country: China facility: The Affiliated Hospital of Xuzhou Medical University status: RECRUITING city: Xuzhou country: China lat: 34.18045 lon: 117.15707 facility: The First Affiliated Hospital of Zhengzhou University status: RECRUITING city: Zhengzhou zip: 450052 country: China lat: 34.75778 lon: 113.64861 facility: Kindai University Hospital status: RECRUITING city: Osaka zip: 589-8511 country: Japan lat: 34.69374 lon: 135.50218 facility: Pusan National University Hospital status: RECRUITING city: Busan zip: 602-739 country: Korea, Republic of lat: 35.10278 lon: 129.04028 facility: Chungbuk National University Hospital status: RECRUITING city: Cheongju si zip: 28644 country: Korea, Republic of lat: 36.63722 lon: 127.48972 facility: Kyungpook National University Chilgok Hospital status: RECRUITING city: Daegu zip: 41404 country: Korea, Republic of lat: 35.87028 lon: 128.59111 facility: St. Vincent's Hospital status: RECRUITING city: Gyeonggi-do zip: 16247 country: Korea, Republic of lat: 37.58944 lon: 126.76917 facility: Pusan National University Yangsan Hospital status: RECRUITING city: Gyeongsangnam-do zip: 50612 country: Korea, Republic of facility: Chonnam National University Hwasun Hospital status: RECRUITING city: Jeollanam-do zip: 58128 country: Korea, Republic of facility: Seoul National University Bundang Hospital status: RECRUITING city: Seongnam-si zip: 463-707 country: Korea, Republic of lat: 37.43861 lon: 127.13778 facility: Seoul National University Hospital status: RECRUITING city: Seoul zip: 03080 country: Korea, Republic of lat: 37.566 lon: 126.9784 facility: Severance Hospital, Yonsei University Health System status: RECRUITING city: Seoul zip: 03722 country: Korea, Republic of lat: 37.566 lon: 126.9784 facility: Asan Medical Center status: RECRUITING city: Seoul zip: 05505 country: Korea, Republic of lat: 37.566 lon: 126.9784 facility: Samsung Medical Center status: RECRUITING city: Seoul zip: 06351 country: Korea, Republic of lat: 37.566 lon: 126.9784 facility: Korea University Guro Hospital status: RECRUITING city: Seoul zip: 08308 country: Korea, Republic of lat: 37.566 lon: 126.9784 facility: Ulsan University Hosiptal status: RECRUITING city: Ulsan zip: 44033 country: Korea, Republic of lat: 35.53722 lon: 129.31667 facility: Kaohsiung Medical Uni Chung-Ho Memorial Hospital; Dept of Internal Medicine status: RECRUITING city: Kaohsiung zip: 807 country: Taiwan lat: 22.61626 lon: 120.31333 facility: Taichung Veterans General Hospital; Dept of Internal Medicine status: RECRUITING city: Taichung zip: 407 country: Taiwan lat: 24.1469 lon: 120.6839 facility: Taipei Veterans General Hospital; Chest Dept , Section of Thoracic Oncology status: RECRUITING city: Taipei zip: 112 country: Taiwan lat: 25.04776 lon: 121.53185 facility: Tri-Service General Hospital; Dept. of Internal Medicine status: RECRUITING city: Taipei zip: 114 country: Taiwan lat: 25.04776 lon: 121.53185 hasResults: False