hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06312930 id: HSEARS20220816001-03 briefTitle: Transcranial Pulse Stimulation on Motor Cortex overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2024-08-20 date: 2024-08-20 date: 2024-03-15 date: 2024-03-18 name: The Hong Kong Polytechnic University class: OTHER briefSummary: Transcranial pulse stimulation (TPS) is a newly developed non-invasive brain stimulation (NIBS) technique from Austria \& Germany with highly promising applicability in neuropsychiatric disorders. Clinical trials have shown a beneficial effect of TPS in patients with Alzheimer's disease and depression. However, the mechanism of action of TPS treatment is unknown. There is a lack of controlled studies with sufficient sample size to draw reliable conclusions on the modulatory effect of TPS. The primary motor cortex is a common target when investigating the neuromodulation effect of NIBS techniques. Here, a randomized, cross-over, double-blind, sham-controlled clinical trial is proposed to probe the effects of TPS over the primary motor cortex on modulating motor response and motor behavior. conditions: Healthy Adults studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 40 type: ESTIMATED name: Transcranial pulse stimulation measure: Change in movement time in nine-hole peg test after TPS measure: Change in reaction time in Deary-Liewald reaction time task after TPS measure: The influence of motor excitability measured by resting motor threshold (RMT) on post-TPS task performance measured by nine-hole peg test and Deary-Liewald reaction time task sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Georg Kranz, PhD city: Hong Kong country: Hong Kong name: Georg Kranz, PhD role: CONTACT phone: 27664838 email: georg.kranz@polyu.edu.hk name: Georg S. Kranz, PhD role: PRINCIPAL_INVESTIGATOR lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06312917 id: 2023PHB183 briefTitle: Effect of Physical Activity Intervention on Overweight and Obese Patients With Endometrial Cancer overallStatus: COMPLETED date: 2023-06-01 date: 2023-12-30 date: 2024-02-01 date: 2024-03-15 date: 2024-03-15 name: Peking University People's Hospital class: OTHER briefSummary: This study evaluated the clinical outcome of exercise management on patients with endometrial cancer treated with fertility preservation, including the effect of complete response rate, complete response time, recurrence rate, recurrence time, etc., and physical composition, to evaluate the effectiveness of physical activity on weight management. conditions: Endometrium Cancer conditions: Physical Activity conditions: Weight Management studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 72 type: ACTUAL name: Physical activity measure: Body weight measure: BMI measure: physical activity level measure: serum total cholesterol measure: Waist Hip Ratio measure: triglyceride sex: FEMALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Peking University People's Hospital city: Beijing state: Beijing country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06312904 id: 2023-GSP-QN-7 briefTitle: Paravertebral Block for Postoperative Analgesia in Children Undergoing Lateral Incision Cardiac Surgery With CBP overallStatus: NOT_YET_RECRUITING date: 2024-03-11 date: 2024-11-30 date: 2024-12-30 date: 2024-03-15 date: 2024-03-15 name: Chinese Academy of Medical Sciences, Fuwai Hospital class: OTHER briefSummary: This study aims to compare the effect of paravertebral block and local infiltration anesthesia on postoperative analgesia in children undergoing lateral incision cardiac surgery with cardiopulmonary bypass. The researchers hope to investigate whether children who undergo paravertebral block experience less postoperative pain, have fewer postoperative complications, and recover more quickly. conditions: Postoperative Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: paravertebral block name: Local infiltration anesthesia measure: opioid consumption during the first 24h after surgery measure: FPS-R scale recorded at 6, 12, 18 and 24h postoperatively measure: The rate of opioid treatment for remedial analgesia between groups measure: Length of postoperative mechanical ventilation measure: Length of ICU/hospital stay measure: The incidence of respiratory depression measure: The rate of postoperative nausea and vomiting (PONV) during the 24h postoperatively sex: ALL minimumAge: 6 Years maximumAge: 14 Years stdAges: CHILD typeAbbrev: Prot_SAP_ICF hasProtocol: True hasSap: True hasIcf: True label: Study Protocol, Statistical Analysis Plan, and Informed Consent Form date: 2024-02-26 uploadDate: 2024-03-08T09:29 filename: Prot_SAP_ICF_000.pdf size: 294106 hasResults: False
nctId: NCT06312891 id: VOHRLTIAM briefTitle: Value of Heart Rate Lowering Therapy in Acute Myocarditis overallStatus: RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-06-01 date: 2024-03-15 date: 2024-03-15 name: Assiut University class: OTHER briefSummary: To study the value of heart rate lowering therapy "pharmacological rest" on the short term in cases of myocarditis without LV dysfunction. conditions: Myocarditis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 150 type: ESTIMATED name: Ivabradine measure: Value of Heart Rate Lowering Therapy in Acute Myocarditis sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Heart Hospital status: RECRUITING city: Assiut country: Egypt name: sara mahmoud, master role: CONTACT phone: 01016862195 email: saramahmoud199783@gmail.com lat: 27.18096 lon: 31.18368 hasResults: False
nctId: NCT06312878 id: IRBN052024/CHUSTE briefTitle: CT Features of Interrupted Inferior Vena Cava With Azygous Continuation overallStatus: RECRUITING date: 2024-03-01 date: 2024-03-31 date: 2024-03-31 date: 2024-03-15 date: 2024-03-15 name: Centre Hospitalier Universitaire de Saint Etienne class: OTHER briefSummary: Inferior vena cava (IVC) is the largest vein is the body, draining blood from the abdomen, pelvis and lower extremities. IVC anomalies can be congenital or acquired.
The aim of this retrospective monocentric study was of describe CT features of interrupted suprarenal inferior vena cava with azygous continuation. conditions: Anatomical Variant of the Inferior Vena Cava studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 10 type: ESTIMATED name: Describe the anatomy of the IVC in the case of an anatomical variant measure: Describe CT features of interrupted suprarenal inferior vena cava with azygous continuation measure: Describe CT features of interrupted suprarenal inferior vena cava with azygous continuation measure: Describe association with polysplenic syndrome measure: Describe association with polysplenic syndrome measure: Describe association with polysplenic syndrome measure: Describe association with polysplenic syndrome measure: Describe association with polysplenic syndrome measure: Describe association with polysplenic syndrome measure: Describe circumstances of discovering the interrupted IVC measure: Describe circumstances of discovering the interrupted IVC sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU de Saint-Etienne status: RECRUITING city: Saint-Priest-en-Jarez zip: 42270 country: France name: Sylvain Grange, MD role: CONTACT phone: (0)477829066 phoneExt: +33 email: grangesylvain@hotmail.fr name: Sylvain Grange, MD role: PRINCIPAL_INVESTIGATOR name: Rémi Grange, MD role: SUB_INVESTIGATOR lat: 45.47501 lon: 4.37614 hasResults: False
nctId: NCT06312865 id: IXTEGYPT briefTitle: Intermittent Exotropia in Egyptian Population overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-07 date: 2025-11 date: 2024-03-15 date: 2024-03-15 name: Assiut University class: OTHER briefSummary: Strabismus is one of the most frequent ocular problems among developmentally normal children. The prevalence of strabismus varies among different regions, ranging from 0.06% in Japan to 5.65% in China. Exotropia is reported to be the most prevalent type of deviation in many of these studies. About 48-92% of the exotropic patients have intermittent exotropia (IXT). Jenkins reported that the prevalence of exodeviation was higher in countries near the Equator. Its prevalence is also higher in subequatorial Africa, the Middle East, and East Asia (where there is plenty of sunshine) in comparison to the USA and Central Europe. Intermittent exotropia is a disorder of binocular eye movement control, where one eye intermittently turns outward. The outward deviation is greatest and likely occurs at far distances viewing, when the oculomotor convergence effort is weakest, and occurs frequently when the patient is under stress, tired, ill, or in particular test situations. X(T) can also occur at near as convergence insufficiency. conditions: Exotropia studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 600 type: ESTIMATED name: Ophthalmic exam measure: The difference in demographic criteria in Egyptian population sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06312852 id: Antenatal steroids & clotting briefTitle: Impact of Antenatal Steroids on Coagulation. overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04 date: 2025-05 date: 2024-03-15 date: 2024-03-15 name: Assiut University class: OTHER briefSummary: Aim of the research :
1- Detection of the presence or absence of any effect of antenatal corticosteroid administration on coagulopathy, fibrinolysis, and other haematological markers. conditions: Corticosteroids Adverse Reaction studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 45 type: ESTIMATED measure: Antenatal corticosteroids impact on Coagulopathy measure: Follow up for cases on corticosteroid therapy sex: FEMALE minimumAge: 15 Years maximumAge: 45 Years stdAges: CHILD stdAges: ADULT hasResults: False
nctId: NCT06312839 id: IRBN032024/CHUSTE briefTitle: Preoperative Arterial Embolization Before Oncologic Esophagectomy as a Technique for Ischemic Gastric Conditioning overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-12 date: 2025-12 date: 2024-03-15 date: 2024-03-15 name: Centre Hospitalier Universitaire de Saint Etienne class: OTHER briefSummary: This retrospective monocentric comparative study aims to assess the efficacy of preoperative ischemic conditioning, in preventing anastomotic leakage in esophageal cancer surgery. Two groups were included : a surgery-alone group (control group) and a PreopAE group (study group) treated with an embolization procedure before esophagectomy. Collected data included patient characteristics, embolization procedure details, surgical outcomes, and postoperative complications.
The primary outcome was the efficacy of preoperative ischemic conditioning in preventing anastomotic leakage, assessed through CT scans. Secondary outcomes included analyzing safety of ischemic gastric conditioning, hypertrophy of the gastroepiploic artery in embolized patients and comparing hospital stay length and postoperative mortality. conditions: Esophageal Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 50 type: ESTIMATED name: Collecting data from the medical record measure: Measurement of the effectiveness of preoperative ischaemic conditioning in reducing anastomotic leakage in patients undergoing oesophagectomy. measure: Measurement of the effectiveness of preoperative ischaemic conditioning in reducing anastomotic leakage in patients undergoing oesophagectomy. measure: Measurement of the effectiveness of preoperative ischaemic conditioning in reducing anastomotic leakage in patients undergoing oesophagectomy. measure: Safety of ischemic gastric conditioning measure: Hypertrophy of the gastroepiploic artery measure: Comparing hospital stay length measure: Comparing postoperative mortality sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU de Saint-Etienne city: Saint-Priest-en-Jarez zip: 42270 country: France name: Rémi Grange, MD role: CONTACT name: Sylvain Grange, MD role: SUB_INVESTIGATOR name: Rémi Grange, MD role: PRINCIPAL_INVESTIGATOR name: Zoé Sahut, resident role: SUB_INVESTIGATOR lat: 45.47501 lon: 4.37614 hasResults: False
nctId: NCT06312826 id: KCT0007417 id: 2022-0661 type: OTHER domain: Asan Medical Center Institutional Review Board briefTitle: Abbreviated MRI Using Gadoxetic Acid Versus Ultrasonography for Surveillance of Early-stage HCC in Patients at High Risk overallStatus: RECRUITING date: 2022-08-26 date: 2024-12 date: 2027-12 date: 2024-03-15 date: 2024-03-15 name: So Yeon Kim class: OTHER briefSummary: Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related deaths worldwide. The incidence of HCC has been rapidly rising worldwide over the last two decades. In order to improve survival with curative treatment, regular surveillance to detect early-stage HCC is recommended for at-risk populations. Although ultrasonography (US) has been endorsed as the primary surveillance tool for HCC, a recent meta-analysis found that US has a sensitivity of 47% for detecting early-stage HCC, and its sensitivity for detecting early-stage HCC has been questioned. Many recent studies have explored the potential of alternative surveillance tools for HCC other than US, particularly for high-risk patients. Although complete gadoxetic acid-enhanced magnetic resonance imaging (MRI) demonstrated excellent performance, its high cost and long examination time can hamper its widespread adoption. Abbreviated MRI (AMRI) including hepatobiliary-phase imaging is a promising option to detect potential indicators of HCC, maintaining the benefits of highly sensitive imaging while reducing the examination time by omitting dynamic contrast-enhanced imaging. Because US is the current primary surveillance tool for HCC, this new surveillance tool must be compared with US in a prospective randomized comparative design.
Thus, the hypothesis to be proved in this study is as follows: AMRI with gadoxetic acid will show a significantly higher detection rate compared to US for the detection of early-stage HCC in patients with cirrhosis and at high risk of developing HCC, defined as an estimated annual HCC risk of higher than 5%. We will also analyze whether the false-referral rate of AMRI with gadoxetic acid is not compromised by its high detection rate. conditions: Liver Cirrhosis conditions: Hepatocellular Carcinoma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: NONE count: 806 type: ESTIMATED name: Abdominal US name: AMRI measure: Detection rate of patients with early stage HCC measure: Detection rate of patients with very early stage HCC measure: False referral rate of patients with early stage HCC measure: False referral rate of patients with very early stage HCC sex: ALL minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Asan Medical Center status: RECRUITING city: Seoul state: Songpa-gu zip: 05505 country: Korea, Republic of name: So Yeon Kim, MD, PhD role: CONTACT phone: 82-2-3010-7166 email: sykim.radiology@gmail.com name: Hyo Jung Park, MD, PhD role: CONTACT phone: 82-2-3010-7166 email: happyeahj@gmail.com name: Jonggi Choi, MD, PhD role: SUB_INVESTIGATOR lat: 37.566 lon: 126.9784 facility: Asan Medical Center status: RECRUITING city: Seoul state: Songpa-gu zip: 05505 country: Korea, Republic of name: So Yeon Kim, MD, PhD role: CONTACT phone: 82-2-3010-6575 email: sykim.radiology@gmail.com name: Hyo Jung Park, MD, PhD role: CONTACT phone: 82-2-3010-6575 email: happyeahj@gmail.com name: Jonggi Choi, MD, PhD role: SUB_INVESTIGATOR lat: 37.566 lon: 126.9784 hasResults: False
nctId: NCT06312813 id: 2023-296 briefTitle: Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea overallStatus: RECRUITING date: 2024-02-27 date: 2028-12 date: 2028-12 date: 2024-03-15 date: 2024-03-15 name: Wright State University class: OTHER briefSummary: Rosacea is a common skin condition associated with easy blushing and red face; many patients with rosacea react to sunlight with increased redness. The purpose of this study is to determine if the use of a topical medication will help reduce sunlight induced redness and irritation in patients with rosacea. conditions: Rosacea studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 48 type: ESTIMATED name: Imipramine name: Amitriptyline name: Vehicle measure: Ultraviolet B induced erythema change with 4% imipramine measure: Ultraviolet B induced erythema change with 4% imipramine measure: Ultraviolet B induced erythema change with 4% imipramine measure: Ultraviolet B induced erythema change with 4% imipramine measure: Ultraviolet B induced erythema change with 4% amitriptyline measure: Ultraviolet B induced erythema change with 4% amitriptyline measure: Ultraviolet B induced erythema change with 4% amitriptyline measure: Ultraviolet B induced erythema change with 4% amitriptyline measure: Tolerability of 4% imipramine on facial skin measure: Tolerability of 4% imipramine on facial skin measure: Tolerability of 4% imipramine on facial skin measure: Tolerability of 4% imipramine on facial skin measure: Tolerability of 4% amitriptyline on facial skin measure: Tolerability of 4% amitriptyline on facial skin measure: Tolerability of 4% amitriptyline on facial skin measure: Tolerability of 4% amitriptyline on facial skin sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Wright State Physicians status: RECRUITING city: Fairborn state: Ohio zip: 45324 country: United States name: Pharmacology Translational Unit role: CONTACT phone: 937-245-7500 email: pturesearch@wrightstatephysicians.org name: Travers role: PRINCIPAL_INVESTIGATOR lat: 39.82089 lon: -84.01938 hasResults: False
nctId: NCT06312800 id: LeWitt02 briefTitle: Acamprosate and Methazolamide for Essential Tremor overallStatus: WITHDRAWN date: 2016-03 date: 2017-06 date: 2017-12 date: 2024-03-15 date: 2024-03-15 name: Henry Ford Health System class: OTHER briefSummary: This is an investigator initiated study is designed to evaluate the anti-tremor benefits of two marketed medications, methazolamide and acamprosate in subjects with a diagnosis of essential tremor (ET). conditions: Essential Tremor studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 0 type: ACTUAL name: Acamprosate name: Placebo name: Methazolamide measure: Fahn-Marin-Tolosa rating scale (FMTRS) Part A sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Henry Ford West Bloomfield Hospital city: West Bloomfield state: Michigan zip: 48322 country: United States lat: 42.56891 lon: -83.38356 hasResults: False
nctId: NCT06312787 id: VX23-118-002 briefTitle: A Study to Evaluate the Relative Bioavailability and Food Effect of a VX-118 Tablet Formulation overallStatus: RECRUITING date: 2024-04-02 date: 2024-05 date: 2024-05 date: 2024-03-15 date: 2024-04-11 name: Vertex Pharmaceuticals Incorporated class: INDUSTRY briefSummary: The purpose of this study is to evaluate the relative bioavailability, effect of food on the pharmacokinetic parameters, and safety and tolerability, of a tablet formulation of VX-118 in healthy participants. conditions: Cystic Fibrosis studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 15 type: ESTIMATED name: VX-118 measure: Maximum Observed Plasma Concentration (Cmax) of VX-118 measure: Area Under the Concentration Versus Time Curve (AUC) of VX-118 measure: Safety and Tolerability as Assessed by Number of Participants With Adverse Events (AEs) sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Celerion - Lincoln status: RECRUITING city: Lincoln state: Nebraska zip: 68502 country: United States lat: 40.8 lon: -96.66696 hasResults: False
nctId: NCT06312774 id: IRAS 333853 briefTitle: Feasibility of Proteomics in Chronic Lung Disease With Sarcopenia overallStatus: NOT_YET_RECRUITING date: 2024-04-18 date: 2025-11-07 date: 2027-01-04 date: 2024-03-15 date: 2024-03-15 name: University College, London class: OTHER briefSummary: Sarcopenia, the loss of muscle mass and strength with ageing, is a prevalent condition in older adults, particularly those with chronic lung diseases like COPD and interstitial lung disease. The condition exacerbates the decline in physical ability, leading to decreased mobility, impaired quality of life, and increased disability. Sarcopenia's prevalence varies across populations, estimated to affect up to 10% of adults over 60 worldwide, with higher rates reported in studies employing consensus definitions of sarcopenia. The prevalence is even higher in patients with chronic lung diseases, reaching up to 26.6%. Sarcopenia's impact on health-related quality of life has been widely investigated. The condition is associated with various comorbidities, including chronic heart failure, obesity, diabetes, and chronic kidney disease, all negatively impacting the quality of life.
The study will also explore potential mechanisms associated with sarcopenia in this population, using proteome and single-cell transcriptome profiles. These multi-omics approaches provide a comprehensive view of the cellular and molecular changes underlying sarcopenia.In particular, the study will evaluate patient acceptance, time efficiency of each test, and recruitment effectiveness. The outcomes will guide the design and execution of subsequent, larger studies and provide preliminary data for power calculation for the full-scale study. conditions: Sarcopenia conditions: Chronic Lung Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 49 type: ESTIMATED name: This is observational study measure: Sarcopenia sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06312761 id: Oral T-12 briefTitle: Single-Dose Pharmacokinetics of Oral Testosterone Undecanoate With and Without Concomitant Inhibition of UGT2B17 acronym: OralT12 overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-12-31 date: 2025-12-31 date: 2024-03-15 date: 2024-03-15 name: University of Washington class: OTHER name: Washington State University briefSummary: This study will be performed in normal men whose endogenous testosterone production has been temporarily suppressed by the administration of a single dose of 120 mg of the oral GnRH antagonist Relugolix, which is approved for the treatment of prostate cancer, and can suppress endogenous testosterone biosynthesis for 48-72 hours after a single dose. conditions: Hypogonadism, Male studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: SINGLE_GROUP primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 10 type: ESTIMATED name: Relugolix 120Mg Tab name: Curcumin name: Testosterone Undecanoate 237 MG Oral Capsule measure: average serum testosterone after dosing on day 2 measure: average serum testosterone after dosing on day 3 measure: Maximum concentration measure: time to maximum concentration measure: area-under-the curve measure: elimination phase half-life sex: MALE minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT hasResults: False