hackint0sh/New-Dataset huggingface dataset:
Outcome measures: The main outcome measures were knee isokinetic muscle strength and Lysholm knee joint score . the secondary outcome measures were Y-balance test, Tegner activity scale, health survey summary table (SF-36),The other outcome measures were Anterior Cruciate Ligament Return to Sport After Injury (ACL-RSI) Scale, vas pain score. conditions: Anterior Cruciate Ligament Reconstruction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 252 type: ESTIMATED name: the traditional rehabilitation group name: the remote rehabilitation group measure: the Lysholm Knee Scoring Scale measure: knee Isokinetic strength measure: Y-balance balance test measure: Tegner score measure: the 36-item Short Form Health Survey(SF-36) measure: Anterior Cruciate Ligament Return to Sport After Injury (ACL-RSI) Scale measure: VAS pain score sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: quan Jian Wang status: RECRUITING city: Beijing state: Beijing zip: 100191 country: China name: quan J Wang, M.D. role: CONTACT phone: 13801076267 email: wjqsportsmed@163.com lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06327542 id: 22-37078B id: 1R61MD018333 type: NIH link: https://reporter.nih.gov/quickSearch/1R61MD018333 briefTitle: Group-based Integrative Pain Management in Primary Care Safety Net Clinics acronym: IPMP+ overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-04-30 date: 2027-04-30 date: 2024-03-25 date: 2024-03-26 name: University of California, San Francisco class: OTHER name: National Institute on Minority Health and Health Disparities (NIMHD) briefSummary: Socioeconomically disadvantaged populations have a high prevalence of chronic pain, exacerbated by social isolation, intersectional stigma, and disparities in pain assessment and treatment options. Effective interventions using a multilevel, biopsychosocial approach are needed to decrease the unequal burden of pain. The proposed study will test group-based integrative models of pain management in primary care safety net clinics to improve pain care for racially and ethnically diverse low-income patients. conditions: Chronic Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL interventionModelDescription: 2x2 factorial trial primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 360 type: ESTIMATED name: Group Acupuncture name: Integrative Group Medical Visits measure: Change in pain impact measured as a composite score of pain intensity, pain interference, and physical function. measure: Change in Social support and Pain Questionnaire (SPQ) measure: Change in average pain intensity on the 0-10 numeric rating scale measure: Self-reported pain interference will be measured using the 8-item NIH Patient Reported Outcomes Measurement Information System (PROMIS) scale. Total t-scores range from 0 to 100, with higher scores indicating greater levels of pain interference. measure: Change in physical function on the 6-item NIH Patient Reported Outcomes Measurement Information System (PROMIS) Physical Function Short Form 6b measure: Change in Internalized Stigma of Chronic Pain (ISCP) survey measure: Change in social isolation on the 8-item NIH Patient Reported Outcomes Measurement Information System (PROMIS) Social Isolation Short Form 8a measure: Change in pain self efficacy on the Pain Self-Efficacy Questionnaire (PSEQ) measure: Change in pain catastrophizing on the Pain Catastrophizing Scale (PCS) 6-item short form measure: Change in depressive symptoms on the Patient Health Questionnaire (PHQ-9) measure: Change in anxiety on the Generalized Anxiety Disorder survey (GAD-2) measure: Patient belief about treatment efficacy on the Patient Global Impression of Change (PGIC) measure: Change in health-related quality of life on NIH Patient Reported Outcomes Measurement Information System (PROMIS) Global Health Scale measure: Change in experiences of discrimination in healthcare sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tom Waddell Urban Health Clinic city: San Francisco state: California zip: 94102 country: United States name: Jesse Wennik, NP role: CONTACT lat: 37.77493 lon: -122.41942 hasResults: False
nctId: NCT06327529 id: 2101814 briefTitle: Zinc and Iron Absorption From Common Beans in Young Adult Women overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-08-31 date: 2024-12-31 date: 2024-03-25 date: 2024-03-26 name: University of California, Davis class: OTHER briefSummary: Fifteen female study participants will be enrolled in a randomized crossover study to measure fractional and total zinc and iron absorption from four common bean (Phaseolus vulgaris) varieties with varying phytate and polyphenolic contents. Phytate, the storage form of phosphorus in plants, and polyphenols, which contribute to the varied colors of common beans, are natural components of the beans and can reduce zinc and iron bioavailability from these foods. conditions: Zinc Absorption conditions: Iron Absorption studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: A four arm multi-tracer non-randomized crossover design primaryPurpose: BASIC_SCIENCE masking: SINGLE maskingDescription: Study participants will be masked to the type of bean that they will be receiving. whoMasked: PARTICIPANT count: 15 type: ESTIMATED name: SER 118 name: LMP 1001 name: LPA 586 name: KAT B1 measure: Fractional Zinc absorption measure: Fractional Iron absorption measure: Total Zinc absorption measure: Total Iron absorption sex: FEMALE minimumAge: 19 Years maximumAge: 24 Years stdAges: ADULT facility: Department of Nutrition city: Davis state: California zip: 95616 country: United States lat: 38.54491 lon: -121.74052 hasResults: False
nctId: NCT06327516 id: M2020023 briefTitle: Lysophosphatidylglycerol in Asthma Pathogenesis overallStatus: RECRUITING date: 2015-01-01 date: 2024-12-31 date: 2025-06-30 date: 2024-03-25 date: 2024-03-26 name: Peking University Third Hospital class: OTHER briefSummary: The study aims to investigate the relationship between the small molecule metabolite lysophosphatidylglycerol and asthma clinical features and explore its involvement in asthma pathogenesis. conditions: Asthma studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 250 type: ESTIMATED measure: lipidomics sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking university third hospital status: RECRUITING city: Beijing state: None Selected zip: 100191 country: China name: Chun Chang role: CONTACT phone: 15810075362 email: doudou1977bysy@sina.com lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06327503 id: 36/7-2024 briefTitle: Salivary Signal Molecules for Neural and Vascular Homeostasis in T2DM overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-06-30 date: 2024-06-30 date: 2024-03-25 date: 2024-03-27 name: University of Belgrade class: OTHER briefSummary: Various signal molecules are detected in blood and tissues of patients with T2DM, that are important for the function of neural tissue in diabetic setting. Among them, specifically important are neuroprotective and neurotrophic growth factors such as nerve growth factor (NGF), glial cells - derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF). Furthermore, several other signal molecules are discovered to affect vascular tissues homeostasis in T2DM, including soluble alpha-klotho (s-Klotho), vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6). Most of these molecules are also detected in saliva in various states and diseases of orofacial system, but data about their levels in saliva of T2DM patients are lacking, although neural and vascular diabetic complications are present in orofacial tissues and organs. Also, there is no data about presence and levels of s-Klotho in saliva of healthy or T2DM patients, although it was reported that this molecule exerts protective effect on the salivary glands tissue. Salivary opiorphin is recently discovered pentapeptide, primarily isolated from saliva. It acts as an inhibitor of the enzymes that perform degradation of endogenous antinociceptive molecules enkephalins, affecting nociceptive signal transduction. This may be of special importance since some intraoral complications of T2DM (e.g. burning mouth) may have underlying peripheral neural changes as a pathophysiological mechanism. Against this background, the aim of the study is to detect the presence and levels of mentioned signal molecules in saliva of patients with and without T2DM. conditions: Type 2 Diabetes studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 30 type: ESTIMATED name: saliva samples collecting measure: NGF levels in saliva measure: GDNF levels in saliva measure: BDNF levels in saliva measure: s-Klotho levels in saliva measure: VEGF levels in saliva measure: IL-6 levels in saliva measure: opiorphin levels in saliva measure: unstimulated saliva flow sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Belgrade School of Dental Medicine city: Belgrade zip: 11000 country: Serbia name: Marija S Milic, DDS Ph.D role: CONTACT phone: +381112646280 phoneExt: 122 email: marija.milic@stomf.bg.ac.rs lat: 44.80401 lon: 20.46513 hasResults: False
nctId: NCT06327490 id: UF-BRE-012 briefTitle: A Study Evaluating the Feasibility and Compliance of Manual Lymphatic Drainage Comparing Indocyanine-Green (ICG) Guided vs. Traditional Guided in Patients Undergoing Axillary Node Dissection for the Treatment of Breast Cancer overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2028-06 date: 2028-06 date: 2024-03-25 date: 2024-04-22 name: University of Florida class: OTHER briefSummary: Breast cancer is estimated to affect approximately 300,000 women in the US in 2023. Studies demonstrate that 1 in 5 will develop breast cancer related lymphedema secondary to the treatments that they receive. BCRL at this time has no cure, however early detection can prevent the progression to late stage BCRL. At this time a technique of arm massage, manual lymphatic drainage (MLD), is used for treatment. This study investigates a new method of MLD, which is guided by the individual patients' lymphatic anatomy through use of ICG-lymphography. conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: ICG-guided manual lymphatic drainage name: Traditional manual lymphatic drainage measure: Subject compliance measure: Relative volume change measure: Bioimpedance measure: Breast cancer related lymphedema symptoms measure: Incidence of progression to late stage breast cancer related lymphedema measure: Health-related quality of life sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Florida city: Gainesville state: Florida zip: 32610 country: United States name: Lisa Spiguel, MD role: PRINCIPAL_INVESTIGATOR lat: 29.65163 lon: -82.32483 hasResults: False
nctId: NCT06327451 id: IRB2024-YX-037-01 briefTitle: Evaluate the Efficacy and Safety of Atorvastatin Combined With Temozolomide in the Treatment of Glioblastoma overallStatus: RECRUITING date: 2024-04-01 date: 2026-02-28 date: 2027-02-28 date: 2024-03-25 date: 2024-03-25 name: Tianjin Medical University General Hospital class: OTHER briefSummary: Glioblastoma (GBM) is the primary intracranial malignant tumor with the highest morbidity and mortality, and the 5-year survival rate is less than 10%. The number of primary diagnostic patients and deaths of GBM in China ranks first in the world every year, which seriously threatens people's life and health. At present, the clinical treatment strategy of maximum surgical resection combined with concurrent chemo- and radio-therapy and TTF treatment is still not satisfactory, and the median survival time of GBM patients is only 14.4 months. Statins inhibit cholesterol production with few side effects and are widely used for cholesterol control in patients with hyperlipidemia. In recent years, statins have shown good anti-tumor effect. Our previous study found that statins can block the malignant progression of glioma mediated by EGFR pathway. Therefore, the investigators report a clinical study protocol designed to evaluate the clinical efficacy of a comprehensive treatment strategy of atorvastatin (ATO) combined with temozolomide (TMZ) in primary and recurrent glioblastomas with high EGFR expression.
The investigators designed a multicenter, single-arm, double-blind, phase II clinical trial to evaluate the efficacy and safety of oral ATO combined with TMZ in EGFR-high expressing GBM. After informed consent was signed by the patient or authorized family members, the patients were treated with the current STUPP regimen and ATO (20mg, qn) orally. The patients were regularly followed up for 52 weeks after treatment. The primary endpoint was progression-free survival (PFS), which was defined as the time from the start of GBM surgery to tumor progression (recurrence) or death. The secondary end point was the rate of tumor control, which was defined as the proportion of patients with a complete response, a partial response, or a stable disease that had shrunk or remained stable for a given period of time. Safety will be assessed during the study by monitoring of regular MRI scans, laboratory tests (liver function, lipid profile, blood routine), electrocardiography, vital signs (blood pressure, pulse, temperature), and weight.
The results of this clinical trial will provide key information on whether the oral combination of atorvastatin and temozolomide prolongs PFS in EGFR-high GBM patients with efficacy and safety. conditions: Glioblastoma, IDH-wildtype studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: Atorvastatin 20mg measure: progression-free survival measure: Overall survival measure: Tumor control rate measure: Hepatic burden of GBM patients after receiving atorvastatin administration measure: Percentage of participants with treatment-related adverse events sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Tianjin Medical University General Hospital status: RECRUITING city: Tianjin zip: 300052 country: China name: Chunsheng Kang role: CONTACT phone: +8602260817499 email: kang97061@tmu.edu.cn name: Xiaoteng Cui role: CONTACT phone: +8602260817481 email: xiaotengcui@tmu.edu.cn lat: 39.14222 lon: 117.17667 hasResults: False
nctId: NCT06327438 id: REC/211/MTI.PT/2401041 briefTitle: Effect of Complex Decongestive Therapy, Cryotherapy and Kinesio Taping in Patients With Post-mastectomy Lymphedema: A Randomized Control Trial overallStatus: RECRUITING date: 2024-03-16 date: 2024-06-16 date: 2024-07-16 date: 2024-03-25 date: 2024-03-25 name: South Valley University class: OTHER briefSummary: To examine the efficacy of complex decongestive therapy (CDT), cryotherapy and kinesio taping (KT) in patients with post-mastectomy lymphedema conditions: Breast Neoplasms studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: randomized controlled study primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: Complex decongestive therapy name: Cryotherapy name: Kinesio taping measure: Arm girth measurement is measured by Circumferential measurements measure: Pain severity is measured by VAS measure: The QOL is measured by SF-36 measure: Range of motion (ROM) is measured by UG sex: ALL minimumAge: 40 Years maximumAge: 60 Years stdAges: ADULT facility: Ragaee Saeed Mahmoud status: RECRUITING city: Giza state: Faisal country: Egypt name: Ragaee Mahmoud role: CONTACT phone: 00201223611112 email: ragaeesaeedpt10@gmail.com name: Reham Mahmoud role: CONTACT phone: 00201015447798 email: rsm_211pt@yahoo.com lat: 30.00808 lon: 31.21093 facility: Ragaee Saeed Mahmoud status: RECRUITING city: Faisal state: Giza zip: 002 country: Egypt name: Reham Saeed, Doctora role: CONTACT phone: 00201223611112 email: rsm_Pt211@yahoo.com name: Rabab Saeed, Doctora role: CONTACT phone: 00201017855222 email: rababSaeed10@yahoo.com lat: 30.01744 lon: 31.20376 hasResults: False
nctId: NCT06327425 id: MCG-Tachyarrhythmia briefTitle: MCG for Localization of Tachyarrhythmia's Origin overallStatus: NOT_YET_RECRUITING date: 2024-03-14 date: 2024-12 date: 2025-02 date: 2024-03-25 date: 2024-03-25 name: Qilu Hospital of Shandong University class: OTHER briefSummary: This is an exploratory research aiming to accurately identify the site of origin of tachyarrhythmia using Magnetocardiography (MCG), which will have guiding significance for early diagnosis, the formulation of treatment plans and preoperative positioning for radiofrequency ablation. conditions: Tachyarrhythmia conditions: Atrial Flutter conditions: Paroxysmal Supraventricular Tachycardia conditions: Atrial Tachycardia conditions: Atrial Fibrillation conditions: Premature Ventricular Contraction studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 1000 type: ESTIMATED name: Magnetocardiography measure: Efficacy of MCG to detect the site of origin of Tachyarrhythmia using cardiac electrophysiology as a reference standard. sex: ALL minimumAge: 18 Years maximumAge: 79 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06327412 id: KayseriCHLYMP01 briefTitle: The Effects of Aerobic Exercise in Patients With Primary Lower Extremity Lymphedema overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-10-01 date: 2024-10-01 date: 2024-03-25 date: 2024-03-27 name: Kayseri City Hospital class: OTHER_GOV briefSummary: Our aim in this study is to evaluate the effects of lymphedema on exercise capacity, body composition, functional level and quality of life in lymphedema patients with primary lower extremity involvement. conditions: Primary Lymphedema conditions: Aerobic Exercise studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A total of 35 patients with primary stage 2 and 3 lower extremity lymphedema, aged 18-65, who apply to the lymphedema outpatient clinic and meet the criteria of the International Society of Lymphology, will be included. Patients participating in the study will be randomized into 2 groups: aerobic exercise group (Group 1) and home exercise group (Group 2). According to randomization, 18 patients will be included in one group and 17 patients in the other.
Cardiopulmonary exercise test (CPET), 30-second-stand-sit test (30s-CST), 6-minute walk test (6MWT), Lymphedema Circumference and Volume Measurement, Bioimpedance Measurement, Lower Extremity Functional Scale (LEFS), Lymphedema Life Impact Scale ( LLIC), Hospital Depression and Anxiety Scale (HADS), Numerical Rating Scale (NRS) forms will be filled in the cardiopulmonary rehabilitation unit of Kayseri City Hospital in the 0th, 4th and 16th weeks. primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 35 type: ESTIMATED name: Aerobic exercise on the treadmill name: Walking between 12-13 RPE (The Borg Rating of Perceived Exertion) according to the Modified Borg Scale measure: 30-second sit-stand test (30-s chair-stand test, 30s-CST) measure: Cardiopulmonary exercise test (CPET) measure: 6-minute walk test (6MWT) measure: Circumference and volume measurement measure: Bioimpedance measurement measure: Lower Extremity Functional Scale (LEFS) measure: Lymphedema Life Impact Scale (LLIC) measure: Hospital Anxiety and Depression Scale (HADS) measure: Numerical Rating Scale (NRS) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Health Sciences University, Kayseri Medicine Faculty, Kayseri City Hospital city: Kayseri zip: 38080 country: Turkey lat: 38.73222 lon: 35.48528 hasResults: False
nctId: NCT06327399 id: MS-373-2023 briefTitle: Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose Before Tracheal Intubation. overallStatus: RECRUITING date: 2024-01-21 date: 2024-04 date: 2024-05 date: 2024-03-25 date: 2024-03-25 name: Kasr El Aini Hospital class: OTHER briefSummary: Dexmedetomidine bolus dose may provide similar or less hemodynamic changes (less bradycardia and less hypertension) than infusion dose during induction of anaesthesia and tracheal intubation. conditions: Dexmedetomidine conditions: Intubation Complication studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 70 type: ESTIMATED name: Dexmedetomidine infusion name: Dexmedetomidine bolus name: Atropine Sulfate name: Ephedrine name: Propofol measure: Mean blood pressure upon laryngoscopy measure: Blood pressure & Heart rate measure: Propfol measure: Bradycardia sex: ALL minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Cairo University Hospitals status: RECRUITING city: Giza zip: 11562 country: Egypt name: Maher a Fawzy, MD role: CONTACT phone: 01201730249 email: kasralainirec@kasralainy.edu.eg lat: 30.00808 lon: 31.21093 hasResults: False
nctId: NCT06327386 id: 202434 briefTitle: The Therapeutic Efficacy of 18F-FDG Combined With 18F-FAPI PET/MR in Neoadjuvant Therapy for Gastric Cancer overallStatus: RECRUITING date: 2024-01-01 date: 2026-01-01 date: 2026-01-01 date: 2024-03-25 date: 2024-03-25 name: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University class: OTHER briefSummary: Gastric cancer is the fifth most common cancer worldwide and the third leading cause of cancer-related deaths. Although surgical treatment can benefit the survival of the vast majority of patients, currently only early gastric cancer patients can be cured directly through endoscopic resection or surgery alone. Neoadjuvant therapy reduces tumor volume and improves tumor response rate through preoperative radiotherapy and chemotherapy, thereby increasing R0 resection rate and improving overall survival, without increasing postoperative complications and mortality. Timely imaging re staging during neoadjuvant therapy can allow patients to enter the surgical stage earlier, thereby reducing their preoperative burden. According to the different stages of neoadjuvant therapy, clinical staging can be divided into baseline stage (cBSstage) and clinical rest stage (cReStage) after neoadjuvant therapy.
At present, the conventional imaging methods for diagnosing cBStage in gastric cancer include CT, endoscopic ultrasonography (EUS), and MRI. The NCCN guidelines recommend CT for cBStage, with a diagnostic accuracy of 77.1% to 88.9%. Similarly, EUS and MRI were also used for cBStage, with accuracy rates of 65.0% to 92.1% and 71.4% to 82.6%, respectively. The application of diffusion-weighted imaging (DWI) has improved the accuracy of MRI diagnosis of cBStage to 93%.