hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06286566 id: UNISS_PHD_Osstem_2 briefTitle: Soi TS3 Surface in Patients With and Without Type 2 Diabetes overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-12-31 date: 2028-01-31 date: 2024-02-29 date: 2024-02-29 name: Università degli Studi di Sassari class: OTHER name: Dr. Dario Melodia name: Dr. Milena Pisano name: Dr. Aurea M. I. Lumbau name: Prof. Silvio Mario Meloni name: Prof. Edoardo Baldoni briefSummary: The aim of this prospective cohort study is to compare clinical and radiographic data of Osstem implants with SOI surface placed in patients with or without diabetes. conditions: Dental Implant conditions: Dental Implant-Abutment Design studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Multicenter prospective cohort study primaryPurpose: TREATMENT masking: SINGLE maskingDescription: centralized radiographic assessor, outcome assessors(when possible), and the statistical advisors will be blind to the used implants whoMasked: OUTCOMES_ASSESSOR count: 84 type: ESTIMATED name: Implant placement with soi surface in diabetic subjects name: Implant placement with soi surface in healthy subjects measure: Number of prosthesis failure: measure: Number of implant failure measure: Number of complication measure: Rate of peri-implant marginal bone level changes measure: Valuation of patient satisfaction sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Marco Tallarico city: Rome state: Sassari zip: 07100 country: Italy lat: 41.89193 lon: 12.51133 hasResults: False
nctId: NCT06286553 id: DRA Rehab TEG & IMT briefTitle: Rehabilitation of Abdominal Diastasis After Childbirth: Trunk and Inspiratory Muscle Training acronym: DR-TIME overallStatus: RECRUITING date: 2024-03-11 date: 2025-05-30 date: 2025-08-30 date: 2024-02-29 date: 2024-03-13 name: University of Patras class: OTHER briefSummary: Diastasis Recti Abdominis (DRA) is the separation of the rectus muscles caused by stretching and thinning of the linea alba during pregnancy and childbirth. It's a common condition, affecting 66-100% of women post-birth and can persist for many years, leading to abdominal protrusion, discomfort, and aesthetic concerns. It might also contribute to back pain, urinary issues, and reduced abdominal strength, impacting quality of life. Recent guidelines propose that conservative management, such as rehabilitation interventions, should be prioritized for DRA. However, there is a lack of consensus among researchers regarding the most effective exercise regimen, resulting in diverse rehabilitation programs. Recent evidence advocates not only for closing the gap but also for achieving optimal function. Current studies often neglect to address functional rehabilitation, underscoring the necessity for robust clinical trials, which is the primary focus of this study.
Additionally, although breathing exercises are commonly prescribed for DRA, the precise role of the diaphragm, the primary respiratory muscle, in rehabilitation hasn't been fully examined. The diaphragm forms the upper boundary of the abdominal cavity and plays a key role in the stability of the trunk, working together with the abdominal and pelvic floor muscles. A recent study found reduced diaphragm excursion in postpartum women with lumbopelvic pain during a low postural demanding task, while previous studies suggest that diaphragm training could alleviate such symptoms influencing factors such as diaphragm thickness and excursion, which may be linked to improved trunk stability. Hence, training the diaphragm and accessory inspiratory muscles through Inspiratory Muscle Training (IMT) could potentially play a crucial role in managing DRA.
In summary, the goal of this study is to develop and assess a comprehensive rehabilitation program aimed at effectively reducing DRA and addressing associated dysfunctions. The program will integrate evidence-based rehabilitation interventions, such as trunk stabilization exercises and IMT, targeting all related dysfunctions caused by DRA, and introducing a novel therapeutic protocol not previously implemented. The study will take the form of a prospective, randomized controlled trial (RCT). conditions: Diastasis Recti And Weakness Of The Linea Alba conditions: Diastasis, Muscle studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: In this interventional study, three distinct groups are included. The Trunk Exercise Group (TEG) will partake in a comprehensive 12-week therapeutic exercise program that involves progressive strengthening exercises specifically targeting the trunk and pelvic floor muscles, alongside functional retraining exercises. The Trunk Exercise and Inspiratory Muscle Training Group (IMT+TEG) will adhere to the same 12-week therapeutic exercise program as TEG, with additional exercises focusing on strengthening the inspiratory muscles using inspiratory resistance (IMT). The control group (CG) will not participate in the 12-week exercise program but will receive a single exercise session and general management information (oral and written) for DRA. primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 48 type: ESTIMATED name: Trunk exercise name: Inspiratory Muscle Training (IMT) name: Control Group measure: Inter-recti distance (IRD) measure: Diaphragmatic Thickness measure: Diaphragmatic Excursion measure: Maximum Inspiratory Pressure (MIP) measure: Strength Index (S-Index) measure: Peak Inspiratory Flow (PIF) measure: Trunk flexion test measure: Plank test measure: Side plank test measure: McGill's trunk flexor endurance test measure: Body Image States Scale (BISS) measure: Activities Assessment Scale (AAS) measure: Hernia-Related Quality-of-Life Survey (HerQLes) sex: FEMALE minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: Laboratory of Clinical Rehabilitation and Research (CPRlab), University of Patras status: RECRUITING city: Patras state: Achaia, Greece zip: 26504 country: Greece name: Evdokia Billis, PhD role: CONTACT phone: 00306973047170 email: billis@upatras.gr name: Anastasia Skoura, MSc role: CONTACT phone: 00306947784948 email: a.skoura@upatras.gr lat: 38.24444 lon: 21.73444 hasResults: False
nctId: NCT06286540 id: 26031993 briefTitle: Evaluation of the Efficacy and Safety of Surgical Device "Lymphoblock" for Prevention of Lymphorrhea in Patients With Thoracoabdominal Aorta Repair. overallStatus: RECRUITING date: 2023-02-22 date: 2026-02 date: 2026-05 date: 2024-02-29 date: 2024-03-15 name: Petrovsky National Research Centre of Surgery class: OTHER briefSummary: Randomized, double-blind, placebo-controlled study will determine the clinical efficacy and safety of Lymphoblock in the prevention of postoperative retroperitoneal chylo-/lymphorrhoea in patients with open surgical treatment of the thoracoabdominal aorta. It is planned to recruit 138 clinical observations. Efficacy will be evaluated based on clinical and laboratory data. conditions: Aorta Abdominalis; Aneurysm conditions: Aorta Thoracic; Aneurysm studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 138 type: ESTIMATED name: Lymphoblock name: Placebo measure: Number of Participants with Chylous Effusion (Сhilo-/lymphorrhea) measure: Number of Participants with Lymphocele measure: The amount of drainage discharge 1 measure: The amount of drainage discharge 2 measure: The amount of drainage discharge 3 measure: Concentration of triglycerides in the drainage discharge measure: Concentration of triglycerides in blood plasma measure: Concentration of cholesterol in the drainage discharge measure: Concentration of cholesterol in the blood plasma measure: Concentration of protein in the drainage discharge measure: Concentration of protein in the blood plasma measure: Concentration of albumin in the drainage discharge measure: Concentration of albumin in the blood plasma measure: Concentration of lactate dehydrogenase in the drainage discharge measure: Concentration of lactate dehydrogenase in the blood plasma measure: Concentration of glucose in the drainage discharge measure: Concentration of glucose in the blood plasma measure: Number of Participants with Pleural effusion within 10 days measure: Number of Participants with Lymphocele 3 months after the surgery measure: Number of Participants with Pleural effusion 3 months after the surgery sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Petrovsky NRCS status: RECRUITING city: Moscow zip: 119991 country: Russian Federation name: Denis Breshenkov, Phd role: CONTACT phone: +79773439041 email: denisbreshenkov@gmail.com name: Boris Tivelev role: CONTACT phone: +79044244886 email: boristivelev@gmail.com name: Omar Mutaev role: SUB_INVESTIGATOR lat: 55.75222 lon: 37.61556 hasResults: False
nctId: NCT06286527 id: EssaiClinique_PREP-QUAL-VS briefTitle: Quality of Sexual Life of PrEP Users acronym: PREP-QUAL-VS overallStatus: NOT_YET_RECRUITING date: 2024-03-06 date: 2024-09-06 date: 2024-09-06 date: 2024-02-29 date: 2024-03-01 name: University Hospital, Grenoble class: OTHER briefSummary: The study will recruit participants on the occasion of their visit in a sexual health center or another HIV pre-exposure prophylaxis (PrEP) facility in France.
PrEP users will be proposed to fill a self-administered, online, anonymous questionnaire regarding how they perceive different fields of their sexual life, and how they perceive that PrEP has an impact on the quality of sexual life. conditions: HIV Pre-exposure Prophylaxis Use conditions: Adult studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: OTHER count: 1000 type: ESTIMATED name: anonymous self-administered online questionnaire measure: quality of sexual life as assessed by a set of questions measure: perceived influence of PrEP use on the quality of sexual life sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Olivier EPAULARD city: Grenoble state: Is zip: 38043 country: France name: Olivier EPAULARD, MD, PhD role: CONTACT phone: +33476765291 email: oepaulard@chu-grenoble.fr lat: 45.16667 lon: 5.71667 hasResults: False
nctId: NCT06286514 id: STUDY00019996 briefTitle: Food at Home Study overallStatus: RECRUITING date: 2024-03-01 date: 2026-03-30 date: 2026-03-30 date: 2024-02-29 date: 2024-04-16 name: University of Minnesota class: OTHER briefSummary: The study objective is to develop an accessible home food environment assessment toolkit that includes valid and reliable paper and electronic tools targeting foods known to impact diet-related health that can be user-administered across literacy levels in English and Spanish. conditions: Obesity conditions: Diet, Healthy studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 350 type: ESTIMATED name: No intervention measure: Usability of HFI core measure: Acceptability of HFI core measure: Concurrent criterion validity of HFI core measure: Concurrent criterion validity of HFI core measure: Convergent construct validity of HFI core measure: Convergent construct validity of HFI core measure: Test-retest reliability of HFI core measure: Usability of eHFI measure: Acceptability of eHFI measure: Concurrent criterion validity of eHFI measure: Concurrent criterion validity of eHFI measure: Convergent construct validity of eHFI measure: Convergent construct validity of eHFI sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Minnesota status: RECRUITING city: Minneapolis state: Minnesota zip: 55414 country: United States name: Sarah Friend role: CONTACT lat: 44.97997 lon: -93.26384 hasResults: False
nctId: NCT06286501 id: R23060L briefTitle: Targeting of Preventive Treatment for Adolescents at Risk of Oral Diseases acronym: LumoPrevent overallStatus: NOT_YET_RECRUITING date: 2024-04-18 date: 2025-09-30 date: 2025-12-31 date: 2024-02-29 date: 2024-04-17 name: Wellbeing Services County of Pirkanmaa class: OTHER name: Tampere University name: University of Helsinki name: Metropolia University of Applied Sciences briefSummary: The aim of the study is to identify adolescent patients that are at risk of developing oral diseases, and to assess if targeted preventive oral treatment with antibacterial dual-light therapy as an adjunctive treatment method can have a positive impact in preventing oral diseases from emerging. conditions: Dental Caries in Children conditions: Dental Plaque conditions: Tooth Decay conditions: Periodontitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized clinical study on a CE-approved medical device primaryPurpose: PREVENTION masking: SINGLE maskingDescription: Data will be collected using individual study codes for participants. Study codes do not reveal which group the participant has belonged to. whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: Lumoral Treatment name: Standard, personalized oral health care measure: Bleeding on probing (BOP) measure: Bleeding on probing (BOP) measure: Active matrix metalloproteinase 8 (aMMP-8) measure: Probing Pocket Depth (PPD) measure: Probing Pocket Depth (PPD) measure: Visible plaque index (VPI) measure: Visible plaque index (VPI) measure: Decayed tooth assessment (DT) measure: Clinical attachment level (CAL) measure: Clinical attachment level (CAL) measure: Microbiological evaluation/16S rRNA analysis measure: Microbiological evaluation/16S rRNA analysis measure: Oral-related quality of life measurement (OHIP-14) measure: Absence of adverse effects sex: ALL minimumAge: 14 Years maximumAge: 16 Years stdAges: CHILD facility: Wellbeing Services of County Pirkanmaa city: Tampere state: Pirkanmaa zip: 33520 country: Finland name: Milla Sarja, dentist role: CONTACT phone: +358405337979 email: milla.sarja@pirha.fi name: Mikko Kylmänen role: CONTACT email: mikko.kylmanen@metropolia.fi name: Anna Maria Heikkinen, Professor role: PRINCIPAL_INVESTIGATOR lat: 61.49911 lon: 23.78712 hasResults: False
nctId: NCT06286488 id: KB/96/2020 briefTitle: Effectiveness and Tolerability of Influenza Vaccine in Patients at Risk for Severe and Complicated Influenza overallStatus: ACTIVE_NOT_RECRUITING date: 2020-09-15 date: 2023-08-23 date: 2026-05-01 date: 2024-02-29 date: 2024-03-01 name: Medical University of Warsaw class: OTHER briefSummary: The aim of the study is to evaluate simultaneously the immunological and clinical efficacy and tolerability of an influenza vaccine, inactivated, quadrivalent, with cleaved virus, in patients at risk for severe and complicated influenza routinely vaccinated against influenza in family medicine clinics or specialty clinics (pediatric, internal medicine, cardiology, gynecological diabetes, pregnant women, transplant). conditions: Influenza conditions: Obesity conditions: Pregnancy; Infection conditions: Elderly Infection conditions: Vaccine Reaction conditions: Vaccine Adverse Reaction conditions: Tolerance studyType: INTERVENTIONAL phases: PHASE4 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 1500 type: ACTUAL name: Vaxigrip measure: influenza vaccine immunogenicity, seroconversion and seroprotection measure: assessment of vaccination tolerance sex: ALL minimumAge: 18 Years maximumAge: 99 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Social Medicine and Public Health, Medical University of Warsaw city: Warsaw zip: 02-077 country: Poland lat: 52.22977 lon: 21.01178 hasResults: False
nctId: NCT06286475 id: VGCS-50635-003 briefTitle: A Study of VRG50635 in Healthy Volunteers overallStatus: RECRUITING date: 2024-02-29 date: 2024-05 date: 2024-05 date: 2024-02-29 date: 2024-03-27 name: Verge Genomics class: INDUSTRY briefSummary: The primary objectives of this study are to investigate the safety and tolerability of VRG50635 and to determine how VRG50635 is absorbed by the body. conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: This is a 2-part study that includes both an open-label (Part 1) and a double-blind, placebo-controlled (Part 2) design. In Part 1, participants will be randomly assigned to receive open-label VRG50635 in 1 of 2 treatment sequences. In Part 2, participants will receive VRG50635 or placebo in a double-blind manner. primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 30 type: ESTIMATED name: VRG50635 name: Placebo measure: Number of Participants with Adverse Events measure: Area Under the Concentration-time Curve from Time 0 Extrapolated to Infinity (AUCinf) measure: Area Under the Concentration-time Curve from Time 0 to the Last Measurable Concentration (AUClast) measure: Area Under the Concentration-time Curve from Time 0 to 24 Hours Post-dose (AUC0-24) measure: Area Under the Concentration-time Curve Between Consecutive Doses (AUCtau) measure: Maximum Observed Concentration (Cmax) measure: Half-life (t1/2) measure: Time of Maximal Plasma Concentration (tmax) sex: ALL minimumAge: 19 Years maximumAge: 55 Years stdAges: ADULT facility: Site 001 status: RECRUITING city: Lincoln state: Nebraska zip: 68502 country: United States lat: 40.8 lon: -96.66696 hasResults: False
nctId: NCT06286449 id: CSV_AUD briefTitle: Identification of Cellular and Molecular Mechanisms Involved in the Pathophysiology of Alcohol Use Disorder by Examination of Cerebrospinal Fluid overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-12-31 date: 2026-12-31 date: 2024-02-29 date: 2024-02-29 name: Vastra Gotaland Region class: OTHER_GOV briefSummary: BACKGROUND
The brain and spinal cord are enveloped by cerebrospinal fluid (CSF), which extends down to the base of the spine, a few centimeters below the termination of the spinal cord. Here, it can be collected through a minor needle puncture. This procedure enables the gathering of information about otherwise concealed molecular and cellular processes in the brain. Analyzing various specific molecules in the CSF has yielded crucial insights into the underlying mechanisms of many neurological and psychiatric disorders, such as multiple sclerosis (MS) and dementia, significantly enhancing the prospects for its treatment. However, for several brain disorders, including Alcohol Use Disorder (AUD) and substance use disorders, CSF studies are absent. AUD, a brain disease affecting the reward system, is characterized by an inability to limit alcohol consumption. High levels of alcohol intake, as seen in AUD, are a leading cause of morbidity and premature mortality. Yet, there is a lack of effective medications for its treatment. Analyzing molecules in CSF, believed to be significant for the development and maintenance of AUD, could enhance the development of effective pharmacological treatments. At present, there are no CSF studies on individuals with AUD, that explore the underlying mechanisms of the disease. Additionally, several CSF studies lack a representative control group of truly healthy controls (i.e. have not presented any neurological or psychiatric symptoms), which is crucial for drawing accurate conclusions.
Individuals with AUD, as well as psychiatrically and neurologically healthy volunteers, will be successively recruited for CSF collection and analyses. Recruitment will be performed through media advertisements and posters within healthcare facilities (The Sahlgrenska University Hospital) and the University of Gothenburg. Additional participants will be recruited from parallel research projects performed within the group (IV-ASA BO10 dnr: 2019-04120, COMB BO8 dnr 431-18, GlycinA BO5 dnr 806-14, PI Bo Söderpalm and NordAlc BO9 dnr: 430-18, PI Andrea de Bejczy) CSF will be obtained through lumbar puncture (spinal tap), a procedure where a thin needle is inserted below the end of the spinal cord. Local anesthesia will be administered in order to mitigate potential discomfort. The lumbar puncture will be performed by an experienced physician, minimizing the risk of injury. Blood samples will also be collected to correlate molecule levels in CSF with those in the blood. Participants will be interviewed about their medical history including their alcohol consumption, and a comprehensive medical examination will be performed.
CSF studies offers unique insights into the cellular and molecular processes within the brain. This approach has been utilized for exploring the mechanisms behind several psychiatric and neurological disorders, but not for certain brain diseases like AUD. AUD inflicts significant suffering for affected individuals, contributes to high mortality rates, and imposes considerable burdens on the society. Moreover, a deeper understanding of the cellular and molecular underpinnings of brain diseases such as AUD, can facilitate the development of novel, more effective medications for its treatment. conditions: Alcohol Use Disorder studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: The intervention in this study consists of a spinal tap that all study participants undergo. We are comparing biomarkers in cerebrospinal fluid collected from either participants with Alcohol Use Disorder or from healthy controls. primaryPurpose: BASIC_SCIENCE masking: NONE count: 50 type: ESTIMATED name: Spinal tap measure: CSF-DA levels sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06286436 id: IR.SBMU.RETECH.REC.1401.842 briefTitle: Effect of Dual-task Training on the Number of EEG Band in Stroke Patients overallStatus: NOT_YET_RECRUITING date: 2024-02-25 date: 2024-04-29 date: 2024-05-29 date: 2024-02-29 date: 2024-03-01 name: Universidad de Zaragoza class: OTHER briefSummary: Stroke is a prevalent global health concern, causing widespread disability as it disrupts blood supply to the brain, leading to functional impairments. Upper limb dysfunction affects over 80% of stroke survivors acutely and becomes permanent in approximately 60%, hindering daily activities and autonomy. Dual-task training (DTT), involving simultaneous cognitive and motor tasks resembling daily activities, is proposed as an effective intervention.
The study suggests using electroencephalogram (EEG) analysis, particularly the Fast Fourier Transform (FFT), to assess changes in brain signals pre- and post-DTT intervention. EEG provides real-time insights into brain function, and FFT analyzes signal frequencies. The intervention involves three tasks performed concurrently with mental calculations, such as sorting blocks and manipulating objects. This 12-session, four-week intervention aims to improve upper limb function. The study explores EEG's role in evaluating DTT effects on stroke patients, particularly using FFT to analyze brain signal frequencies. conditions: Stroke conditions: Electroencephalography studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 5 type: ESTIMATED name: Dual-task training measure: EEG Data measure: Upper limb function measure: Elbow flexor muscle tone measure: Wrist extension range of motion measure: ADLs sex: FEMALE minimumAge: 35 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shahid Beheshti University of Medical Sciences city: Tehran state: Velenjak country: Iran, Islamic Republic of name: Borhan Asadi, Eng role: CONTACT lat: 35.69439 lon: 51.42151 hasResults: False
nctId: NCT06286423 id: HSR220446 briefTitle: Colchicine in Acutely Decompensated HFREF overallStatus: RECRUITING date: 2024-03 date: 2026-02 date: 2028-02 date: 2024-02-29 date: 2024-03-20 name: University of Virginia class: OTHER briefSummary: This is a double blind, placebo-controlled pilot trial randomizing patients admitted to the hospital with acutely decompensated heart failure (ADHF) and inflammation to receive either colchicine or matching placebo.