hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06321328 id: ChatGpt postoperative ICU briefTitle: Success of ChatGPT in Determining the Need for Postoperative Intensive Care overallStatus: NOT_YET_RECRUITING date: 2024-03-16 date: 2024-04-16 date: 2024-05-01 date: 2024-03-20 date: 2024-03-20 name: Kanuni Sultan Suleyman Training and Research Hospital class: OTHER briefSummary: This is a prospective, observational study to be conducted at Sağlık Bilimleri University Istanbul Kanuni Sultan Süleyman Training and Research Hospital and Başakşehir Çam and Sakura City Hospital. The study aims to record various preoperative and postoperative data of patients who have undergone surgeries, specifically those with ASA scores of III and IV or those indicated to potentially need postoperative intensive care. Data points include patient demographics, type of surgery, ASA score, comorbidities, lab and imaging findings, and both actual and ChatGPT version 4 predicted outcomes regarding postoperative intensive care needs, anesthesia methods, duration of stay in intensive care and the hospital, and 30-day mortality rates. ChatGPT version 4's predictions will be compared with actual outcomes and anesthesiologist decisions. conditions: Artificial Intelligence conditions: Intensive Care Unit conditions: PACU Length of Stay studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 398 type: ESTIMATED measure: Intensive care predictions sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: istanbul Kanuni Sultan Süleyman Education and Training Hospital city: Istanbul zip: 34303 country: Turkey name: Yeşim Özay role: CONTACT phone: 0090212 404 15 00 phoneExt: 2144 lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06321315 id: KSUESRAKARATASOKYAY006 briefTitle: The Effect of Case-based Teaching on Midwifery Undergraduate Students overallStatus: RECRUITING date: 2024-03-19 date: 2024-04-30 date: 2024-04-30 date: 2024-03-20 date: 2024-04-05 name: Kahramanmaras Sutcu Imam University class: OTHER briefSummary: Case-based teaching will be applied to second year midwifery undergraduate students. The intervention group (case-based teaching implementation group) and the control group each consist of 35 students. conditions: Midwifery Students studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Intervention group (Case-based instruction group) Control group primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 70 type: ESTIMATED name: Case-based instruction measure: Determination of Critical Thinking Motivation measure: Determination of Critical Thinking Motivation measure: Determining the level of Academic Motivation measure: Determining the level of Academic Motivation measure: Determining the status of access to information measure: Determining the status of access to information measure: Evaluation of satisfaction with the training methods used and the effect of training methods on perceptions of competence during clinical practice measure: Evaluation of satisfaction with the training methods used and the effect of training methods on perceptions of competence during clinical practice sex: FEMALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Kahramanmaras Sutcu Imam University status: RECRUITING city: Kahramanmaraş state: Kahramanmaras zip: 46050 country: Turkey name: Esra KARATAŞ OKYAY, PhD role: CONTACT phone: 05432125225 email: esrakaratas44@hotmail.com name: Pınar KARA, PhD role: CONTACT phone: 0507 957 0859 email: karapinar@hotmail.com lat: 37.5847 lon: 36.92641 hasResults: False
nctId: NCT06321302 id: 1436-0007 id: 2023-508891-12-00 type: REGISTRY domain: CTIS id: U1111-1299-0915 type: REGISTRY domain: Universal Trial Number briefTitle: A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy overallStatus: NOT_YET_RECRUITING date: 2024-05-08 date: 2026-07-01 date: 2026-11-11 date: 2024-03-20 date: 2024-03-27 name: Boehringer Ingelheim class: INDUSTRY briefSummary: This study is open to adults with diabetic retinopathy. People who have non-proliferative diabetic retinopathy of moderate or high severity can join the study.
The purpose of this study is to find out whether a medicine called BI 764524 helps people with diabetic retinopathy. The study also aims to find a suitable treatment plan for BI 764524. Participants are put into 5 groups by chance. Participants in groups 1, 2, and 3 get BI 764524. Over 1 year, they get a different number of injections of the same dose of BI 764524 injected into 1 eye. During some visits, participants may get a sham control, which is done like an eye injection but without a needle, so that participants will not know how many injections of BI 764524 they received. Participants in group 4 only get a sham control. Participants in group 5 (only in the USA) get aflibercept or sham injections during some visits. Aflibercept is a medicine already used to treat diabetic retinopathy.
Participants are in the study for one and a half years. During this time, they visit the study site at least 16 times. During this time, doctors regularly do eye exams and visual tests to assess the severity of participants' eye condition. After 1 year of treatment, researchers look at the number of participants with eye improvements. To do so, they compare eye damage and certain severe eye problems between the groups of participants. The doctors also regularly check participants' health and take note of any unwanted effects. conditions: Diabetic Retinopathy studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 175 type: ESTIMATED name: BI 764524 name: Sham comparator to BI 764524 name: Aflibercept (Eylea®) - US only measure: Occurrence of a ≥2-step improvement compared with baseline in Diabetic Retinopathy Severity Scale (DRSS) level in the study eye at Week 52 measure: Occurrence of vision threatening complications (VTC)s in the study eye between baseline and Week 52 measure: Absolute change from baseline of best corrected visual acuity (BCVA) [early treatment diabetic retinopathy study (ETDRS) letters] in the study eye at Week 52 measure: Absolute change from baseline of central retinal thickness [μm], as assessed by spectral domain optical coherence tomography (SD-OCT), in the study eye at Week 52 measure: Occurrence of a ≥2-step worsening of Diabetic Retinopathy Severity Scale (DRSS) in the study eye between baseline and Week 52 measure: Occurrence of proliferative diabetic retinopathy (PDR) and/or anterior segment neovascularisation (NV) in the study eye between baseline and Week 52 measure: Occurrence of centre-involved diabetic macular edema (CI-DME) in the study eye between baseline and Week 52 measure: Occurrence of drug-related adverse events (AEs) between baseline and end of study (EOS) measure: Occurrence of ocular AEs in the study eye between baseline and EOS measure: Occurrence of ocular AEs of special interest in the study eye between baseline and EOS sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06321289 id: CHN-PLAGH-BT-084 briefTitle: Allogeneic TRAC Locus-inserted CD19-targeting STAR T Cell Therapy in r/r B-NHL overallStatus: RECRUITING date: 2024-03-20 date: 2026-03-20 date: 2027-03-20 date: 2024-03-20 date: 2024-03-25 name: Chinese PLA General Hospital class: OTHER briefSummary: The team has developed the synthetic T cell receptor (TCR) and antigen receptor (STAR) T cells which were demonstrated safety in relapsed or refractory (r/r) B-cell non-Hodgkin' s lymphoma (B-NHL) (NCT05631912). Based on this research, allogeneic STAR-T cell products utilized the CRISPR-Cas9 gene editing tool to knock out endogenous receptor α constant (TRAC), human leukocyte antigen (HLA)-A/B, CIITA, and programmed death 1 (PD-1) genes simultaneously in T cells from healthy donors, and integrated the STAR molecule into the TRAC locus using adenovirus associated virus. This strategy can reduce graft-versus-host-disease (GvHD) toxicity and host-versus-graft response, decrease the sensitivity of STAR T cells to immunosuppressive signals, and improve their anti-tumor activity. In this single center, prospective, open-label, single-arm, phase 1/2 study, the safety and efficacy of allogeneic CD19-targeting STAR T cell therapy will be evaluated in patients with r/r B-NHL. conditions: Non-hodgkin Lymphoma,B Cell studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Allogeneic CD19-STAR T cell name: Fludarabine name: Cyclophosphamide measure: Phase 1: Incidence of Adverse Events (AEs) defined as DLT measure: Phase 1: RP2D measure: Phase 2: Best objective Response Rate measure: Phase 2: Overall Survival (OS) measure: Phase 2: Progression Free Survival (PFS) measure: Phase 2: Time to response (TTR) measure: Phase 2: Duration of Response (DOR) measure: Pharmacokinetics: Number and copy number of CD19-STAR T cells (phase 1 and phase 2) measure: Pharmacokinetics: Persistence of CD19-STAR T (phase 1 and phase 2) measure: Pharmacodynamics: Peak level of cytokines in serum (phase 1 and phase 2) measure: Phase 1: Levels of donor-specific anti-HLA antibodies (DSA) in blood. sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Biotherapeutic Department of Chinese PLA General Hospital status: RECRUITING city: Beijing state: Beijing zip: 100853 country: China name: Weidong Han, M.D role: CONTACT phone: +86-010-66937463 email: hanwdrsw@sina.com name: Qingming Yang, M.D role: SUB_INVESTIGATOR name: Yang Liu, M.D role: SUB_INVESTIGATOR name: Jinhong Shi, M.S role: SUB_INVESTIGATOR name: Chunmeng Wang, M.S role: SUB_INVESTIGATOR lat: 39.9075 lon: 116.39723 facility: School of medicine, Tsinghua University & Changping Laboratory status: RECRUITING city: Beijing country: China name: Xin Lin, Ph.D role: CONTACT phone: +86-010-62796319 email: linxin307@mail.tsinghua.edu.cn name: Xin Lin, Ph.D role: SUB_INVESTIGATOR lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06321276 id: AEU-FTR-ID-01 briefTitle: Investigation of the Efficiency of Radial Extracorporeal Shock Wave Therapy at Different Pulses in Carpal Tunnel Syndrome overallStatus: RECRUITING date: 2024-03-18 date: 2024-04-15 date: 2024-06-01 date: 2024-03-20 date: 2024-03-20 name: Ahi Evran University Education and Research Hospital class: OTHER briefSummary: Different parameters have been used in studies investigating the efficacy of extracorporeal shock wave therapy in the treatment of carpal tunnel syndrome. Although extracorporeal shock wave therapy has been shown to have a positive effect on carpal tunnel syndrome, there is no consensus on which pulse rate is more effective. Therefore, in this study, the efficacy of extracorporeal shock wave therapy applied at different pulse rates in the treatment of carpal tunnel syndrome will be examined. conditions: Carpal Tunnel Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: three groups with a conventional therapy control group primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Patient whoMasked: INVESTIGATOR count: 90 type: ESTIMATED name: extracorporeal shockwave therapy measure: Visual analogue scale (VAS) measure: Boston Carpal Tunnel Syndrome Questionnaire measure: Hand grip strength measurement measure: Electromyoneurography (EMNG) measure: Ultrasonography sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Kirsehir Ahi Evran University status: RECRUITING city: Kırşehir zip: 40100 country: Turkey name: ibrahim Doğru, MD role: CONTACT phone: 5353127880 phoneExt: +90 email: www.skillcraft@hotmail.com name: ismail ceylan, PhD role: CONTACT phone: 5364634679 phoneExt: +90 email: fztceylan@gmail.com lat: 39.14583 lon: 34.16389 hasResults: False
nctId: NCT06321263 id: 798307 briefTitle: Comparison of the Effects of Peripheral Muscle Training and Inspiratory Muscle Training in Geriatric Individuals overallStatus: NOT_YET_RECRUITING date: 2024-03-25 date: 2024-09-27 date: 2025-03-21 date: 2024-03-20 date: 2024-03-29 name: Biruni University class: OTHER briefSummary: In geriatric individuals, there is a decrease in muscle strength, muscle mass and physical performance with ageing. These physiological changes occurring in geriatric individuals make maintaining the physical activity necessary for a healthy life difficult. Weakness of respiratory muscles in geriatric individuals can increase the prevalence of diseases and disability. It has been shown in the literature that peripheral muscle training and inspiratory muscle training increase exercise capacity similarly. The effectiveness of moderate-intensity peripheral muscle training and inspiratory muscle training in sarcopenic geriatric individuals was compared and found to have similar effects on muscle strength.
Our study aims to compare the effects of inspiratory and peripheral muscle training in addition to aerobic exercise on muscle strength, physical performance, respiratory muscle strength, functional capacity, sarcopenia, and quality of life. conditions: Muscle Strength studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Peripheral Muscle Training and step aerobics training name: Inspiratory Muscle Training and step aerobics training measure: The sociodemographic data form measure: Hand grip strength measure: Maximal inspiratory and expiratory pressures (MIP, MEP) measure: 6-Minute Walk Test (6MWT) measure: The Short Physical Performance Battery (SPPB) measure: Assessment of seniors᾽ quality of life: WHOQOL-OLD questionnaire measure: SARC-F questionnaire measure: Canadian Occupational Performance Measure sex: ALL minimumAge: 65 Years maximumAge: 80 Years stdAges: OLDER_ADULT hasResults: False
nctId: NCT06321250 id: JY-JM3948-101 briefTitle: A Study of JMKX003948 Tablets in Patients With Renal Cell Carcinoma overallStatus: NOT_YET_RECRUITING date: 2024-03-28 date: 2026-05-31 date: 2027-04-30 date: 2024-03-20 date: 2024-03-20 name: Jemincare class: INDUSTRY name: Zhejiang Hangyu Pharmaceutical Co., Ltd briefSummary: This open-label Phase 1 study will evaluate the safety, tolerability, PK characteristics and preliminarily efficacy of JMKX003948 tablets in patients with renal cell carcinoma. conditions: Renal Cell Carcinoma Metastatic studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 80 type: ESTIMATED name: JMKX003948 measure: Dose Escalation: Number of participants with dose limiting toxicities (DLTs) measure: Dose Escalation: Incidence and severity of adverse events (AEs) and serious adverse events (SAEs) measure: Dose Expansion: Objective Response Rate (ORR) measure: maximum plasma concentration (Cmax) measure: maximum plasma concentration (Tmax) measure: Duration of Response (DoR) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06321237 id: TJ-IRB202402130 briefTitle: Influence of Ear Vagus Nerve Stimulator on Patients With IBS overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-05-26 date: 2024-06-09 date: 2024-03-20 date: 2024-03-20 name: Huaping Xie class: OTHER briefSummary: Irritable bowel syndrome (IBS) is a very common functional digestive disorder characterized by chronic abdominal pain and altered bowel habits in the absence of biological or structural abnormalities. In the field of IBS, effective drug treatments are very limited, and patients are urgently looking for alternatives, including probiotics, hypnotherapy, osteopathy, dietary changes, and fecal microbiota transplants. In recent years, with the continuous elucidation of vagus nerve mechanisms, IBS patients are increasingly interested in bioelectrical regulation, and these patients are often skeptical of traditional drug treatment and believe that drugs are prone to side effects. For several reasons, vagus nerve stimulation (VNS) may be a promising option for improving IBS symptoms. In this experiment, the portable ear nail stimulator produced by Ruishen Medical can accurately stimulate the ear nail, transdermal stimulation of the ear vagus nerve, and give full play to its therapeutic effect. Therefore, the purpose of this clinical trial is to use ear nail stimulator in patients with IBS to explore whether it has therapeutic effects on patients with IBS. To explore the influence of tVNS therapy on irritable bowel syndrome compared with drug therapy, it is hoped that the use of TVNS therapy can reduce the use of related drugs, or even replace drugs. This study intends to recruit a group of patients with irritable bowel syndrome to use the portable ear nail stimulator, (1) to observe whether the symptoms of irritable bowel syndrome patients are improved; (2) To analyze the changes of intestinal microbes in patients with IBS; (3) Verify whether the level of intestinal inflammation is reduced and discover metabolic markers in the intestine. conditions: Irritable Bowel Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 40 type: ESTIMATED name: Vagus nerve stimulation for 8 weeks name: Vagus nerve stimulation for the first 4 weeks name: Vagus nerve stimulation for the last 4 weeks name: Pseudostimulus measure: Changes in irritable bowel symptoms measure: Changes in the diversity of intestinal flora measure: Changes in the relative abundance of species of intestinal flora measure: Changes in the number of intestinal flora sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2024-02-07 uploadDate: 2024-03-11T05:59 filename: Prot_SAP_000.pdf size: 2489139 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2024-02-07 uploadDate: 2024-03-11T06:13 filename: ICF_001.pdf size: 273802 hasResults: False
nctId: NCT06321224 id: 2024/03/08 briefTitle: Effects of Breathing Exercises on Women With Primary Dysmenorhea overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-05 date: 2025-03 date: 2024-03-20 date: 2024-03-20 name: Ankara Yildirim Beyazıt University class: OTHER briefSummary: The aim of this study is to examine the effects of breathing exercises in women with primary dysmenorrhea. conditions: Dysmenorrhea studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 42 type: ESTIMATED name: Breathing exercises name: Control measure: Menstrual pain intensity measure: Menstrual symptoms measure: Life quality measure: Stress level measure: Sleep quality sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06321211 id: RECAS-0244 briefTitle: Development of a Novel Asian Mediterranean Diet and Its Acceptability in NAFLD acronym: aMed overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-06-30 date: 2024-12-27 date: 2024-03-20 date: 2024-03-20 name: Singapore Institute of Technology class: OTHER name: Singapore Health Services briefSummary: The goal of this pre-intervention study is test the acceptability of Asian version of the Mediterranean diet to NAFLD patients.
Participants will participate in taste test sessions to find out if the Asian Mediterranean diet meals are acceptable to people with NAFLD. conditions: Fatty Liver, Nonalcoholic studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 30 type: ESTIMATED measure: Sensory Evaluation Test Score NAFLD sex: ALL minimumAge: 21 Years maximumAge: 60 Years stdAges: ADULT typeAbbrev: Prot_SAP hasProtocol: True hasSap: True hasIcf: False label: Study Protocol and Statistical Analysis Plan date: 2024-02-02 uploadDate: 2024-02-29T00:58 filename: Prot_SAP_000.pdf size: 135277 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form: Consent Form Only date: 2024-03-02 uploadDate: 2024-03-06T09:36 filename: ICF_001.pdf size: 732118 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form: Participant Information Sheet date: 2024-03-02 uploadDate: 2024-03-13T21:38 filename: ICF_002.pdf size: 861264 hasResults: False
nctId: NCT06321198 id: iMSC-2001 briefTitle: A Trial to Evaluate the Safety and Preliminary Efficacy of iMesenchymal Stromal Cells(iMSC) in Subjects With SR-aGVHD overallStatus: RECRUITING date: 2024-02-10 date: 2027-03-02 date: 2027-03-02 date: 2024-03-20 date: 2024-03-20 name: Anhui Provincial Hospital class: OTHER_GOV briefSummary: A study to evaluate the safety and preliminary efficacy of iMSC in subjects with SR-aGVHD conditions: Steroid-refractory Acute Graft-versus-host Disease(SR-aGVHD) studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: iMSC measure: Dose-Limiting Toxicity(DLT) measure: Adverse Event(AE),Serious Adverse Event(SAE),Treatment Emergent Adverse Event(TEAE)and Treatment Related Adverse Event(TRAE) measure: Objective Response Rate(ORR) measure: Overall Survival(OS) sex: ALL minimumAge: 4 Years maximumAge: 70 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Anhui Provincial Hospital status: RECRUITING city: Hefei state: Anhui zip: 230036 country: China name: Zhu Xiaoyu, Ph.D role: CONTACT phone: +86 15255456091 email: xiaoyuz@ustc.edu.cn name: Sun Guangyu role: CONTACT phone: +86 13956970687 email: sunguangyu_vip@foxmail.com lat: 31.86389 lon: 117.28083 hasResults: False