hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06347952 id: SE1188 briefTitle: Mapping Arterial Perforators Within the Breast During Mammoplasty acronym: Map-total overallStatus: COMPLETED date: 2022-04-27 date: 2024-01-25 date: 2024-01-29 date: 2024-04-04 date: 2024-04-04 name: Royal Marsden NHS Foundation Trust class: OTHER briefSummary: Breast cancer surgery can often be carried out as part of a breast reduction procedure known as 'therapeutic mammoplasty'. Where a woman has a breast with adequate volume, even larger cancers can be removed in an aesthetically acceptable way with re-shaping of the breast (often reduction and lift) incorporated into the cancer removal. An expectation and desire for most women is that the nipple and areola (known as the 'nipple-areolar complex' or NAC) is not only preserved, but re-positioned (usually lifted) to re-balance the overall aesthetic result.
In addition, we evaluate the training potential of patients undergoing symmetrising breast reduction, whereby the tissue removed is first mapped using acoustic doppler as for the NAC above. conditions: Breast Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 80 type: ACTUAL name: Use of Acoustic and color imaging doppler during surgery for breast cancer measure: Full-thickness (complete or partial) necrosis of nipple-areolar complex sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Royal Marsden - Surrey city: Sutton state: England zip: SM2 5PT country: United Kingdom lat: 51.35 lon: -0.2 hasResults: False
nctId: NCT06347939 id: 2023-06638-01 briefTitle: Mediastinal EBUS Cryobiopsy Study In Sweden acronym: MECRIS overallStatus: RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2028-12-31 date: 2024-04-04 date: 2024-04-19 name: Region Skane class: OTHER briefSummary: This study is a prospective observational non-randomized clinical trial where all the participitants undergo the same procedure and every participitant's samples are compared to each other. The investigators conduct EBUS TBNA and EBUS TBMCB on all the study participants.The cryobiopsy samples are numbered to evaluate the number of biopsies needed to reach a definite diagnosis and to assess the added value of every sample taken from the same participitant. Every participitant's own samples are compared to each other and added value of EBUS TBMCB is defined as the difference in diagnostic yield between the EBUS TBNA alone and the combination of EBUS TBNA with EBUS TBMCB. Diagnostic yield is defined as the efficacy of the investigation module in reaching a definite diagnosis (percentage of cases with a definite diagnosis).
Follow up four weeks after the procedure to assess the risk for postoperative complications. conditions: Mediastinal Lymphadenopathy conditions: Lung Cancer conditions: Sarcoidosis conditions: Lymphoma conditions: Tuberculosis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED name: Mediastinal lymph nodes cryobiopsies measure: Number of mediastinal cryobiopsies needed per patient to lead to a definite diagnosis. measure: Adequacy of mediastinal cryobiopsies for PDL1 analysis in lung cancer. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Respiratory medicine and allergy department, Skåne University Hospital status: RECRUITING city: Lund country: Sweden name: Hamid Akbarshahi, MD, PhD role: CONTACT phone: 004646171000 email: hamid.akbarshahi@med.lu.se lat: 55.70584 lon: 13.19321 facility: Norrlands universitetssjukhus status: RECRUITING city: Umeå country: Sweden name: Annelie Behndig, MD, PhD role: CONTACT phone: 0907850000 email: annelie.behndig@umu.se lat: 63.82842 lon: 20.25972 hasResults: False
nctId: NCT06347926 id: PROICM 2023-11 EVA briefTitle: Evaluation of the Effect of Photobiomodulation on Sexual Quality of Life in Women With Breast Cancer acronym: EVABIOSEIN overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-08 date: 2025-08 date: 2024-04-04 date: 2024-04-04 name: Institut du Cancer de Montpellier - Val d'Aurelle class: OTHER briefSummary: The treatment of breast cancer as well as the disease are responsible for genito-urinary symptoms that can persist over time and impair quality of life. Given the improved prognosis of breast cancer, more and more patients are confronted with specific post-cancer issues, and the care has become a major health challenge.
Vaginal dryness is part of a broader syndrome known as genitourinary syndrome of menopause (GSM), or vulvovaginal atrophy, which may combine vulvovaginal (dryness, irritation, burning), sexual (dyspareunia) and urinary (infections, pollakiuria, urgency) symptoms secondary to hypoestrogenemia, exacerbated by breast cancer treatments. Since hormonal treatments are contraindicated, the first-line treatment for GSM in patients treated for breast cancer is the application of non-hormonal trophic treatments (regular vaginal moisturizers, lubricants during intercourse). However, these treatments are often insufficient to provide effective relief. There is therefore growing interest in the development of second-line treatments for GSM : intra-vaginal hyaluronic acid injections, laser, photobiomodulation (PBM), etc. PBM using Light Emitting Diodes (LED) has been proposed as an alternative treatment for genitourinary syndrome of the menopause. The tissues are exposed to light sources in the visible spectrum, inducing non-thermal, non-cytotoxic biological effects that improve vaginal tissue trophicity. A study is planned to evaluate the use of photobiomodulation in 2nd-line treatment of GSM (after 1st-line treatment with vaginal moisturizers) and on the quality of sexual life of patients treated for breast cancer at any stage of treatment. conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Treatment by photobiomodulation primaryPurpose: TREATMENT masking: NONE count: 25 type: ESTIMATED name: Photobiomodulation measure: Sexual satisfaction score on one dimension of the SHQ-22 questionnaire measure: Sexual quality of life scores obtained on all dimensions of the SHQ-22 questionnaire measure: Patient Global Impression of Improvement (PGI-I) score measure: Determination of the Vaginal Health Index clinical score measure: Determination of symptoms of vulvovaginal atrophy by a visual numerical scale measure: Determination of adverse events by using Common Terminology Criteria for Adverse Events (CTCAE) scale of the National Cancer Institute. measure: Number of patients taking other treatments for treating sexual troubles sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Institute of Cancer in Montpellier city: Montpellier state: Hérault zip: 34298 country: France name: Angélique Bobrie, MD role: CONTACT phone: 467618576 phoneExt: +33 email: angelique.bobrie@icm.unicancer.fr name: Angélique Bobrie, MD role: PRINCIPAL_INVESTIGATOR lat: 43.61092 lon: 3.87723 hasResults: False
nctId: NCT06347913 id: Soh-Med-24-03-09MS briefTitle: Umblical Artery Systolic \Diastolic Ratio and Amniotic Fluid Index in Prediction of Fetal Outcome in Term Pregnancy overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-08 date: 2025-03 date: 2024-04-04 date: 2024-04-04 name: Sohag University class: OTHER briefSummary: Antepartum fetal surveillance is the cornerstone of management in pregnancy. \[1\] It is done primarily to reduce the incidence of adverse fetal outcomes. It minimizes morbidity by optimizing the timing of delivery. Fetus at risk of chronic hypoxia is identified and unnecessary interventions are avoided. However, fetal surveillance acts as a diagnostic modality to detect the influence of maternal, placental, and fetal factors on the fetus. The timely detection of morbid changes in the fetal status followed by adequate interventions to avoid death or disability is one of the most important objectives of prenatal care. \[2\] Tests now commonly done for antepartum fetal surveillance are nonstress test (NST), amniotic fluid index (AFI), biophysical profile, Doppler study of umbilical artery (UA), and middle cerebral artery (MCA).\[3 6\] However, AFI and UA Doppler velocimetry both form an essential part of the antenatal surveillance in the assessment of fetal well being. UA Doppler is a powerful tool that allows the obstetrician to follow a sequence of fetal hemodynamic events that happen in response to placental insufficiency. \[7\] However, several studies have reported higher sensitivities and specificities for UA Doppler ratio for prediction of fetal prognosis. \[3 6\] Amniotic fluid is the product of complex and dynamic fetal and placental physiologic processes. Disruption of the fine balance may result in overproduction or underproduction of fluid. Liquor adequacy often reflects the fetal status. Oligohydramnios is associated with increased perinatal loss. Furthermore, other studies indicate that UA velocimetry is a predictor of adverse outcomes in pregnancies complicated by oligohydramnios. \[8,9\] Thus, arterial Doppler velocimetry measurement may be useful in predicting adverse pregnancy outcomes adjunct to other antenatal surveillance tests, especially the AFI. Therefore, the present study will be done to evaluate the comparative assessment of UA ratio and AFI in predicting adverse perinatal outcomes. conditions: Umblical Artery Doppler in Term Pregnancy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 213 type: ESTIMATED name: ultrasound measure: Umbilical Artery Systolic/Diastolic Ratio sex: FEMALE minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Sohag university Hospital city: Sohag country: Egypt name: Magdy M Amin, professor role: CONTACT lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06347900 id: Soh-Med-23-09-7PD briefTitle: Corneal Topographic Changes in Different Grades of OSA overallStatus: RECRUITING date: 2024-01-01 date: 2024-04-30 date: 2024-06-30 date: 2024-04-04 date: 2024-04-04 name: Sohag University class: OTHER briefSummary: Corneal topographic parameters in different degrees of obstructive sleep apnea conditions: Corneal Ectasia studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: Pentacam (corneal topographic changes detection), Polysymnography measure: Keratometric readings in diopters, corneal thickness in um, average progression index value, anterior and posterior corneal elevation values. sex: ALL minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT facility: Ophthalmology department, Sohag University status: RECRUITING city: Sohag zip: 82511 country: Egypt name: Elshimaa A.Mateen role: CONTACT phone: 0201282223427 email: elshimaa.moussa@yahoo.com lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06347887 id: SGI-PCR-01 briefTitle: Clinical Validation of ColonAiQ (a Blood-based Assay Targeting ctDNA Methylation) for Colorectal Cancer Detection overallStatus: COMPLETED date: 2021-05-31 date: 2024-01-16 date: 2024-01-16 date: 2024-04-04 date: 2024-04-04 name: Singlera Genomics Inc. class: INDUSTRY briefSummary: The DNA methylation targets in preoperative plasma samples of the subjects will be detected by the multi-gene methylation test (ColonAiQ), and the test accuracy will be evaluated by compared with the clinical diagnosis evidence. conditions: Colorectal Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1965 type: ACTUAL name: ColonAiQ test and Colonoscopy measure: Sensitivity for colorectal cancer with ColonAiQ test measure: Specificity for colorectal cancer with ColonAiQ test measure: PPV for colorectal cancer with ColonAiQ test measure: NPV for colorectal cancer with ColonAiQ test sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Affiliated Hospital of Xuzhou Medical University city: Xuzhou state: Jiangsu zip: 221000 country: China lat: 34.18045 lon: 117.15707 facility: The First Affiliated Hospital of Shandong First Medical University city: Jinan state: Shandong zip: 250000 country: China lat: 36.66833 lon: 116.99722 facility: Shanxi Provincial People's Hospital city: Taiyuan state: Shanxi zip: 030012 country: China lat: 37.86944 lon: 112.56028 facility: Xi'an Daxing Hospital city: Xi'an state: Shanxi zip: 710000 country: China lat: 34.25833 lon: 108.92861 facility: Xi'an Gaoxin Hospital city: Xi'an state: Shanxi zip: 710000 country: China lat: 34.25833 lon: 108.92861 facility: Zhejiang provincial people's hospital city: Hangzhou state: Zhejiang zip: 310000 country: China lat: 30.29365 lon: 120.16142 facility: Fudan University Shanghai Cancer Center city: Shanghai zip: 200032 country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06347874 id: ANES-2024-32820 briefTitle: Cryo Rib Fracture Study overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05-31 date: 2026-11-30 date: 2024-04-04 date: 2024-04-04 name: University of Minnesota class: OTHER briefSummary: The purpose of this study is to determine if patients with rib fractures who undergo cryoablation of the intercostal nerves have improved pain control 7 days from procedure when compared to those who have a ESP catheter. conditions: Rib Fractures studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a randomized prospective controlled trial. This will be single blinded trial. The individual doing the outcome assessments will be blinded. Randomization will be 1:1. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The individual doing the outcome assessments will be blinded. whoMasked: OUTCOMES_ASSESSOR count: 48 type: ESTIMATED name: Cryoablation name: ESP Catheter measure: Maximum pain score on POD (Post Operative Day) 7 measure: Opioid Use measure: Functional Pain Scores measure: Number of Patients using opioids at POD 30 measure: Length of hospital stay measure: Number of patients returned home by POD 30 measure: time to first ambulation measure: number of patients admitted to ICU measure: number of patients that required mechanical ventilation measure: Pulmonary Function Testing. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06347861 id: C4891003 briefTitle: A Study to Learn How Various Tablets of the Study Medicine Vepdegestrant Are Taken up Into the Blood of Healthy Adults overallStatus: RECRUITING date: 2024-04-02 date: 2024-06-16 date: 2024-07-05 date: 2024-04-04 date: 2024-04-16 name: Pfizer class: INDUSTRY name: Arvinas Estrogen Receptor, Inc. briefSummary: The purpose of the study is to look at how various tablets of a study medicine called vepdegestrant are processed in the body. This will be studied in healthy adult participants after food.
The study consists of 3 treatments. Each participant will be assigned by chance to receive the 3 treatments in a certain sequence. This will be done over 3 study periods. Each treatment consists of a single amount of vepdegestrant taken by mouth in each study period. There will be a washout period between each study periods. The washout period is the time allowed for the medicine to get washed out from the body. How the medicine was processed will be calculated following each dose in each period. The total study duration is about 13 weeks. conditions: Healthy studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: OTHER masking: NONE count: 48 type: ESTIMATED name: single dose of vepdegestrant as tablet formulation (Treatment A) name: single dose of vepdegestrant as tablet formulation (Treatment B) name: single dose of vepdegestrant as tablet formulation (Treatment C) measure: Maximum observed concentration (Cmax) for vepdegestrant measure: Area under the curve from time zero to extrapolated infinite time [AUC (0 - ∞)] for vepdegestrant measure: Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs) measure: Number of Participants With Clinical Laboratory Abnormalities measure: Number of Participants With Clinically Significant Change From Baseline in Vital Signs measure: Number of Participants With Electrocardiogram (ECG) Abnormalities sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Prism Research LLC dba Nucleus Network status: RECRUITING city: Saint Paul state: Minnesota zip: 55114 country: United States lat: 44.94441 lon: -93.09327 hasResults: False
nctId: NCT06347848 id: IstanbulUCKA briefTitle: The Effect of Psychoeducation Focused on Reducing Internalized Stigma overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2024-05-01 date: 2024-09-01 date: 2024-04-04 date: 2024-04-04 name: Istanbul University - Cerrahpasa (IUC) class: OTHER briefSummary: In the fight against stigma, the focus should be on the education of individuals diagnosed with mental illness. Psychoeducation has an important place in the treatment and rehabilitation of mental health problems. Psychoeducation is necessary for early recognition of signs and symptoms of diseases, ensuring compliance with treatment, improving coping skills, as well as combating stigma, preventing internalized stigma, and counteracting social stigma. If individuals with mental disorders have adequate knowledge about the causes of stigma, they may be less prone to internalized stigma. conditions: Schizophrenia conditions: Treatment Adherence conditions: Stigma, Social studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Two parallel groups randomized control study primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 40 type: ESTIMATED name: Psychoeducation Focused on Reducing Internalized Stigma measure: Internalized Stigma of Mental Illness Scale measure: Medication Adherence Reporting Scale sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istanbul University - Cerrahpasa (IUC) city: Istanbul state: Şişli country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06347835 id: Gut-Intervention-SAR-2024 briefTitle: Biomarker Identification and Nutritional Intervention of Primary Sarcopenia Based on Gut-muscle Axis overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2026-01 date: 2024-04-04 date: 2024-04-22 name: Peking Union Medical College Hospital class: OTHER briefSummary: The loss of skeletal muscle mass and function usually occurs with aging, known as primary sarcopenia. Sarcopenia has a prevalence of 11.6% among the elderly population in China and is closely associated with increased risks of falls, disability, and mortality. Currently, there is a lack of definition criteria for sarcopenia based on biomarkers. The Gut-Muscle Axis hypothesis suggests a complex interplay between gut microbiota and skeletal muscle. Nutritional intervention targeting the gut microbiota potentially plays a significant role in muscle regeneration. Therefore, this study aims to explore the effects of symbiotic and whey protein on muscle, gut microbiota, and clinical outcomes among sarcopenia patients, to provide a reference for further diagnosis and treatment of sarcopenia. conditions: Sarcopenia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 120 type: ESTIMATED name: symbiotic name: whey protein name: symbiotic placebo name: whey protein placebo measure: Change from Baseline of Appendicular skeletal muscle mass index at 12 weeks measure: Change from Baseline of grip strength at 12 weeks measure: Change from Baseline of Short Physical Performance Battery score at 12 weeks measure: Change from Baseline of gait speed at 12 weeks measure: Change from Baseline of gut microbiota composition at 12 weeks measure: Change from Baseline of inflammation status at 12 weeks measure: Change from Baseline of microbiota-derived metabolites at 12 weeks sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Peking Union Medical College Hospital city: Beijing state: Beijing zip: 100730 country: China name: Kang Yu, MD role: CONTACT phone: +86 010-69155550 email: yuk1997@sina.com lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06347822 id: 23-011276 briefTitle: Increasing Access to Evidence-Based Care in Integrated Behavioral Health overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-10 date: 2024-10 date: 2024-04-04 date: 2024-04-04 name: Mayo Clinic class: OTHER briefSummary: The purpose of this research is to explore whether a single-session therapy visit may be of interest to patients seeking mental health services in Mayo Clinic's Integrated Behavioral Health program and whether a single-session therapy visit may be helpful in improving mental health. Researchers hope to better understand whether single-session visits could be a helpful option to offer patients in the future. conditions: Psychotherapy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 34 type: ESTIMATED name: Therapy Session measure: Satisfaction with IBH therapy measure: Satisfaction with Action Plan measure: Change in readiness for change scores measure: Change in PHQ-9 scores measure: Change in GAD-7 scores measure: Change in Valuing Questionnaire (Values Progress subscale) measure: Change in Valuing Questionnaire (Values Obstruction subscale) measure: Change in CompACT scores (Valued Action) measure: Change in CompACT scores (Openness to Experience) measure: Change in CompACT scores (Behavioral Awareness) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mayo Clinic in Rochester city: Rochester state: Minnesota zip: 55905 country: United States lat: 44.02163 lon: -92.4699 hasResults: False
nctId: NCT06347809 id: 18-006343 id: NCI-2024-01225 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: 18-006343 type: OTHER domain: Mayo Clinic Institutional Review Board briefTitle: DNA Methylation in Adenocarcinoma of the Prostate: Analysis of Validated Biomarkers in Urine overallStatus: ENROLLING_BY_INVITATION date: 2018-11-07 date: 2029-02-01 date: 2029-02-01 date: 2024-04-04 date: 2024-04-19 name: Mayo Clinic class: OTHER briefSummary: This study explores the potential use of DNA markers in the detection of prostate cancer and patient perceptions of this screening approach and other current or future prostate cancer screening and diagnostic tests. conditions: Prostate Adenocarcinoma conditions: Prostate Carcinoma studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 300 type: ESTIMATED name: Non-Interventional Study measure: Accuracy of methylated DNA markers (MDMs) for detection of cancer of the prostate (CAP) measure: Accuracy of CAP detection measure: Comparison of sample volumes sex: MALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mayo Clinic in Rochester city: Rochester state: Minnesota zip: 55905 country: United States lat: 44.02163 lon: -92.4699 hasResults: False
nctId: NCT06347796 id: 23-0160 id: 1UG3NS128397-01A1 type: NIH link: https://reporter.nih.gov/quickSearch/1UG3NS128397-01A1 briefTitle: Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study acronym: CHESS overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2029-09 date: 2029-09 date: 2024-04-04 date: 2024-04-04 name: The University of Texas Medical Branch, Galveston class: OTHER name: National Institute of Neurological Disorders and Stroke (NINDS) briefSummary: The goal of this clinical trial is to test in moderately symptomatic chronic subdural hematoma (CSDH) patients if middle meningeal artery embolization (MMAE) can be used as an alternative to conventional open surgery. The main questions it aims to answer are: