hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06346600 id: SKG0106-LF briefTitle: A Long-term Follow-up Study to Evaluate SKG0106 in the Treatment of Patients With nAMD overallStatus: RECRUITING date: 2024-04-02 date: 2031-03 date: 2031-03 date: 2024-04-04 date: 2024-04-04 name: Skyline Therapeutics class: INDUSTRY briefSummary: This is a Prospective, Non-interventional, Multicenter, Long-term Follow-up Study to Evaluate SKG0106 in the Treatment of Patients with Neovascular (Wet) Age-related Macular Degeneration (nAMD). All subject who completed the parent clinical study (NCT06213038 and NCT05986864) will undergo safety and efficacy assessments up to 5 years post study drug injection. conditions: Neovascular (Wet) Age-related Macular Degeneration studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 83 type: ESTIMATED name: SKG0106 measure: Type, severity, and incidence of ocular and systemic adverse events (AEs), serious adverse events (SAEs), and adverse events of special interest (AESIs) measure: Mean change in best corrected visual acuity (BCVA) at each visit from baseline measure: Mean change in macular central subfield thickness (CST) at each visit from baseline measure: Mean change in patient-reported outcome (VFQ-25) scale scores at each visit from baseline sex: ALL minimumAge: 50 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ophthalmic Consultants of Boston status: NOT_YET_RECRUITING city: Boston state: Massachusetts zip: 02114 country: United States lat: 42.35843 lon: -71.05977 facility: Retina Consultants of Texas status: NOT_YET_RECRUITING city: Katy state: Texas zip: 77494 country: United States lat: 29.78579 lon: -95.8244 facility: Wagner Macula & Retina Center status: NOT_YET_RECRUITING city: Norfolk state: Virginia zip: 23502 country: United States lat: 36.84681 lon: -76.28522 facility: The Second Hospital Of Anhui Medical University status: NOT_YET_RECRUITING city: Hefei state: Anhui country: China lat: 31.86389 lon: 117.28083 facility: Zhejiang Provincial People's Hospital status: NOT_YET_RECRUITING city: Hangzhou state: Zhejiang country: China lat: 30.29365 lon: 120.16142 facility: Eye Hospital, WMU (Zhejiang Eye Hospital) status: NOT_YET_RECRUITING city: Wenzhou state: Zhejiang country: China lat: 27.99942 lon: 120.66682 facility: Beijing Hospital status: NOT_YET_RECRUITING city: Beijing country: China lat: 39.9075 lon: 116.39723 facility: Peking Union Medical College Hospital status: RECRUITING city: Beijing country: China lat: 39.9075 lon: 116.39723 facility: EYE & ENT Hospital of Fudan University status: RECRUITING city: Shanghai country: China lat: 31.22222 lon: 121.45806 facility: Xinhua Hospital Affiliated To Shanghai Jiao Tong University School Of Medicine status: NOT_YET_RECRUITING city: Shanghai country: China lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06346574 id: STUDY-0004282 briefTitle: HEART at Head Start Pilot (Healthy Eating, Activity, Relaxation Trial) acronym: HEART overallStatus: RECRUITING date: 2023-12-14 date: 2024-11 date: 2024-12 date: 2024-04-04 date: 2024-04-04 name: Tufts University class: OTHER name: United States Department of Agriculture (USDA) name: National Head Start Association briefSummary: With funding from the United States Department of Agriculture (USDA), the Tufts University's Friedman School of Nutrition Science and Policy will be implementing a new, health and wellbeing program for Head Start educators at ABCD Head Start Centers in the greater Boston area.
A paper and pencil survey will be used to gather information on dietary, physical activity, and sleep behaviors. The surveys will also include a module on satisfaction with the health and wellness App and Guides. Survey data will be combined with the administrative data about App utilization. conditions: Dietary Habits conditions: Physical Inactivity conditions: Sleep Hygiene studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Study participants will be educators at Head Start centers where either the intervention is offered at the onset of the study (intervention group) or after six months (comparison condition). primaryPurpose: OTHER masking: NONE count: 200 type: ESTIMATED name: Experimental measure: Use of health and wellness App measure: Engagement with Guide measure: Nutrition behaviors measure: Physical activity behaviors measure: Sleep habits measure: BMI measure: Cholesterol measure: Triglycerides measure: Blood pressure measure: Blood glucose sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tufts University status: RECRUITING city: Boston state: Massachusetts zip: 02111 country: United States name: Katrina Sarson, MS, MEd role: CONTACT phone: 617-636-3737 email: katrina.sarson@tufts.edu name: Sujata Dixit-Joshi, MPH, PhD role: CONTACT phone: 617-636-3737 email: sujata.dixit_joshi@tufts.edu name: Christina Economos, PhD role: PRINCIPAL_INVESTIGATOR lat: 42.35843 lon: -71.05977 hasResults: False
nctId: NCT06346561 id: Soh-Med-24-02-10MS briefTitle: The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study overallStatus: RECRUITING date: 2024-03-30 date: 2024-08-30 date: 2024-08-30 date: 2024-04-04 date: 2024-04-04 name: Sohag University class: OTHER briefSummary: The most important symptoms of nasolacrimal duct obstruction are excessive tearing and mucoid discharge.
Hence, there is no enough studies about controlled hypotension in DCR we decided to perform such a comparison between the effect of dexmedetomidine and labetalol in providing controlled hypotension during DCR surgery. conditions: Nasolacrimal Duct Obstruction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: Dexmedetomidine name: Labetalol measure: Assess non invasive blood pressure during DCR surgery To compare between the effect of dexmedetomidine and labetalol in providing controlled hypotension. measure: Effectiveness of dexamedetomidine for prolongation of postoperative analgesia. sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Sohag University hospitals status: RECRUITING city: Sohag country: Egypt name: Magdy M Amin, Professor role: CONTACT lat: 26.55695 lon: 31.69478 hasResults: False
nctId: NCT06346548 id: VF-ES-DIG briefTitle: Study on the Chromatic Perception of Digital Systems in Aesthetic Field overallStatus: NOT_YET_RECRUITING date: 2024-09-27 date: 2025-06-15 date: 2025-06-15 date: 2024-04-04 date: 2024-04-04 name: Paolone Gaetano class: OTHER briefSummary: The study under consideration aims to evaluate differences in chromatic perception among three distinct color acquisition methodologies. Specifically, recruited patients will undergo testing with three different color detection systems, including two intraoral photography methodologies and one digital intra oral scanning. All procedures conducted are part of normal clinical practice. conditions: Color Detection of Upper Central Incisors studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 78 type: ESTIMATED name: oral photography measure: Comparison of chromatic values of the upper central incisors sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS San Raffaele city: Milano zip: 20132 country: Italy name: Federico Vannini role: CONTACT phone: +393450764177 email: f.vannini@studenti.unisr.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06346522 id: FMASU R37/2024 briefTitle: Gabapentin Versus Trospium Chloride for Prevention of a Catheter-related Bladder Discomfort Inside the ICU overallStatus: RECRUITING date: 2024-02-24 date: 2024-07 date: 2024-08 date: 2024-04-04 date: 2024-04-04 name: Ain Shams University class: OTHER briefSummary: Catheter-related bladder discomfort (CRBD) is a frequent complaint after urinary bladder catheterization which is commonly done in the perioperative period. CRBD shows similar symptoms to overactive bladder (OAB); so, drugs used for the management of OAB could influence symptoms of CRBD. Trospium chloride and gabapentin are effective in managing patient with OAB even the resistant cases. We will evaluate and compare the efficacy of both oral trospium and gabapentin on prevention of CRBD in the postoperative period in the ICU in in patients undergoing spinal surgery and requiring intraoperative catheterization of the urinary bladder. conditions: Catheter-related Bladder Discomfort (CRBD) studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A prospective, randomized, comparative, clinical trial study primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Gabapentin (Gaptin ®) 400mg oral capsule once name: Trospium chloride slow release (Trospikan ® SR) 60mg oral capsule measure: The incidence (yes/no) and severity of catheter-related bladder discomfort (CRBD) in 1,2,6,12,24 hours after the study drugs intake measure: Total fentanyl requirements in micrograms (µg) measure: Numerical Pain Rating Scale (NPRS) (0-10) measure: Side effects of the study drugs measure: Ramsay sedation score sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Ain Shams University-Faculty of Medicine status: RECRUITING city: Cairo country: Egypt name: Ahmed M Mohamed, MD role: CONTACT phone: 002 01121318459 email: drahmed.mostafa.mohamed@med.asu.edu.eg name: Wessam Z Selima, MD role: CONTACT phone: 002 01001958858 email: w.z.selima@med.asu.edu.eg lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06346509 id: PORT-77-101 briefTitle: Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose Study of PORT-77 Administered to Healthy Adult Participants overallStatus: NOT_YET_RECRUITING date: 2024-04-08 date: 2024-12-23 date: 2024-12-23 date: 2024-04-04 date: 2024-04-04 name: Portal Therapeutics, Inc. class: INDUSTRY briefSummary: A First-in-Human 2-part, randomized, double-blind, placebo-controlled, single ascending dose, multiple ascending dose, and food effect, investigation of the administration of PORT-77 in healthy adult participants. conditions: Healthy Adult Participants studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 108 type: ESTIMATED name: PORT-77 name: Placebo measure: Number of incidence and severity of adverse events (AEs) as a measure of safety and tolerability of PORT-77 (Part I) measure: Number of incidence and severity of AEs as a measure of safety and tolerability of PORT-77 (Part II) measure: Plasma concentration of a single-dose of PORT-77 (Part I) measure: Plasma concentration of the steady-state of PORT-77 (Part II) measure: Plasma concentration of PORT-77 by effect of a standardized high-fat/high-calorie meal (Part I) measure: Evaluate effects of single doses of PORT-77 on ECG parameters (Part I) measure: Evaluate effects of single doses of PORT-77 on ECG parameters (Part II) sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: Celerion city: Tempe state: Arizona zip: 85283 country: United States role: CONTACT email: mara.baier@celerion.com name: Mara Baier, DO role: PRINCIPAL_INVESTIGATOR lat: 33.41477 lon: -111.90931 hasResults: False
nctId: NCT06346496 id: H23133 briefTitle: Young People Aged 18-25 With Depression or Anxiety Mood Participate in an LLM-based Digital Dialogue Intervention Study overallStatus: COMPLETED date: 2023-11-20 date: 2023-12-18 date: 2024-01-15 date: 2024-04-04 date: 2024-04-09 name: Institute of Psychology, Chinese Academy of Sciences class: OTHER briefSummary: This study is a 28-day randomized controlled trial (RCT). Residents were randomly assigned to an intervention group or a waiting group according to the order in which they were successfully contacted by the staff, and each user was asked to engage in a total of 28 days of dialog intervention with the Douyin companion bot and complete three psychological questionnaires (on Days 1, 14, and 28); however, the intervention group began to receive the dialog intervention after completing the first questionnaire, and the waiting group began to receive the dialog intervention after completing the third questionnaire. During the first four weeks, the waiting group was treated as a blank control. The two groups of subjects completed the three questionnaires at exactly the same point in time. Each user's depression, anxiety, and positive and negative emotions were measured using the Patient Health Questionnaire (PHQ-9), the Generalized Anxiety Disorder Scale (GAD-7) and the Positive and Negative Affect Schedule (PANAS), respectively. conditions: LLM-based AI Dialogue Bot conditions: Depression conditions: Anxiety studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE whoMasked: PARTICIPANT count: 657 type: ACTUAL name: Douyin Xinqing AI dialog bot name: Douyin Xinqing AI dialog bot for delayed intervention measure: Depression measure: Anxiety measure: Positive and negative moods sex: ALL minimumAge: 18 Years maximumAge: 25 Years stdAges: ADULT facility: Institute of Psychology, Chinese Academy of Sciences city: Beijing state: Beijing country: China lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06346483 id: STU00218929 briefTitle: Ureteroscopy With High-powered Holmium:Yag Laser Lithotripsy With and Moses On or Moses Off overallStatus: RECRUITING date: 2023-06-09 date: 2024-06-09 date: 2025-06-09 date: 2024-04-04 date: 2024-04-04 name: Northwestern University class: OTHER name: Ohio State University briefSummary: The purpose of this study is to compare Moses 2.0 pulse modulation technology and the standard high powered Holmium Laser lithotripsy and how it will affect time in the operating room, time using the laser, laser energy, and stone free rates.
The study will be including kidney and ureteral stones (a kidney stone located in the tube between the kidney and the bladder) that are 6mm and greater, but less than 20 mm in size undergoing ureteroscopic treatment. High powered lasers are used for "dusting". Dusting is when a laser is used to break a stone down into tiny fragments that are able to pass through the urine. conditions: Kidney Stone conditions: Ureteral Stone studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 150 type: ESTIMATED name: Dusting measure: Operative time measure: Stone Free Rate measure: Lasing time measure: Total laser energy (kJ) measure: Detection of postoperative strictures sex: ALL minimumAge: 18 Years maximumAge: 90 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Northwestern Medicine status: RECRUITING city: Chicago state: Illinois zip: 60611 country: United States name: Alyssa McDonald role: CONTACT lat: 41.85003 lon: -87.65005 hasResults: False
nctId: NCT06346470 id: 3430-12 briefTitle: The Effect of Web-Based Breast Self-Examination Education overallStatus: RECRUITING date: 2024-02-19 date: 2024-05-31 date: 2024-05-31 date: 2024-04-04 date: 2024-04-04 name: Istanbul University - Cerrahpasa (IUC) class: OTHER briefSummary: Breast cancer is the most common type of cancer among women. Reasons such as diagnosing breast cancer at an early stage increases the chances of treatment and survival, and the fact that the masses are largely noticed by the individual themselves, point to the importance of breast self-examination (BSE) . BSE skill is among the nursing skills. When the literature was examined, it was seen that the web-based education method was frequently used for cognitive skills during nursing education, but its use was limited for psychomotor skills training. It was determined that in BSE training, in addition to traditional education, methods such as concept maps and peer-supported education were used, but web-based education methods were not used. It is thought that the study will contribute to the literature in these aspects. conditions: Education conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE whoMasked: PARTICIPANT count: 88 type: ESTIMATED name: Web-based breast self examination education measure: Skill and Knowledge of BSE measure: Attitude of Web-Based Education measure: Self-Directed Learning Skills sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Florence Nightingale Faculty of Nursing status: RECRUITING city: Istanbul state: Şişli zip: 34381 country: Turkey name: Olga İncesu, PhD role: CONTACT phone: 05334942989 email: olga.incesu@iuc.edu.tr name: Olga İncesu, PhD role: PRINCIPAL_INVESTIGATOR name: Öykü Kara, Msc role: SUB_INVESTIGATOR lat: 41.01384 lon: 28.94966 hasResults: False
nctId: NCT06346457 id: IRTG_P08 briefTitle: Breast Cancer & Antiestrogenic Therapy & Brain overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-12-01 date: 2026-04-01 date: 2024-04-04 date: 2024-04-04 name: International Research Training Group 2804 class: OTHER name: German Research Foundation name: University Hospital Tuebingen name: Uppsala University briefSummary: The study aims to investigate the effect of anti-estrogenic therapy in breast cancer patients on neural reward processing, psychosexual health, and quality of life, in reproductive vs. menopausal women. The investigators are directly comparing four groups 1) premenopausal women diagnosed with breast cancer receiving anti-estrogenic therapy, 2) postmenopausal women diagnosed with breast cancer with and without previous hormonal replacement therapy, receiving anti-estrogenic therapy, 3) premenopausal healthy women, and 4) postmenopausal healthy women. Furthermore, via assessment and integration of various data including subjective/self-report data via questionnaires and a standardized interview, physiological/endocrine (via blood sample), psychological and neural data (including anatomical scans, Diffusion tensor imaging (DTI), resting state, and a reward processing paradigm), this project will shed light on the connection between the brain, anti-estrogenic therapy, and psychosexual health. conditions: Breast Cancer Female conditions: Healthy Female conditions: Menopause conditions: Anti-estrogenic Therapy studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: OTHER count: 180 type: ESTIMATED name: Tamoxifen name: Letrozole name: Letrozole + GnRH measure: Correlations between antiestrogen hormone therapy and brain function & structure measure: Correlations between antiestrogen hormone therapy and reward processing in both behavioral and neural aspects measure: Brain Disparities: Contrasting Breast Cancer Patients with Healthy Controls measure: Reward Processing Disparities: Contrasting Breast Cancer Patients with Healthy Controls measure: Brain Disparities: Contrasting Breast Cancer Patients with Healthy Controls measure: Correlation between antiestrogen hormone therapy and psychosexual health measure: Correlation between antiestrogen hormone therapy and quality of life measure: Psychosexual Health Disparities: Contrasting Breast Cancer Patients with Healthy Controls measure: Psychosexual Health Disparities: Contrasting Breast Cancer Patients with Healthy Controls measure: Correlation between antiestrogen hormone therapy and cognitive changes measure: Quality of Life Disparities: Contrasting Breast Cancer Patients with Healthy Controls sex: FEMALE minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Tuebingen; Department of Psychiatry & Psychotherapy Tuebingen city: Tuebingen state: BW zip: 72076 country: Germany lat: 48.52266 lon: 9.05222 hasResults: False
nctId: NCT06346444 id: 2.780.113 briefTitle: Biomarkers in Rett Syndrome acronym: BIRS overallStatus: RECRUITING date: 2020-08-03 date: 2024-02-20 date: 2024-12-31 date: 2024-04-04 date: 2024-04-04 name: IRCCS Fondazione Stella Maris class: OTHER name: Meyer Children's Hospital IRCCS name: Azienda USL Toscana Nord Ovest name: University of Dublin, Trinity College briefSummary: Rett syndrome (RTT) is an X-linked genetic disorder that causes severe neurological development disorder. In its classic form, it seems to affect almost exclusively females with an incidence of up to one in 10,000 females. Patients affected by Rett Syndrome can present a wide range of symptoms, in different combinations and of varying intensity, such as slowed growth of head circumference, abnormalities in walking and balance, loss of functional use of the hands often replaced by repetitive and stereotyped hand movements like "hand washing", loss of communicative-relational skills including expressive language, epilepsy, breathing abnormalities, and osteo-muscular alterations. In light of the growing potential of clinical therapies, identification and early diagnosis are considered essential. Many disease modification strategies have been achieved through translational research studies and clinical trials that have allowed the recognition of the most effective therapeutic and clinical interventions to date.
This study arises from the need to advance in the understanding of the pathogenesis of RTT through a multicentric collaboration in order to (a) identify early biomarkers of RTT (b) delve into the alterations of interconnectivity, crucial for understanding the loss of motor functions and language through systematic collection of anamnestic, genetic, and clinical-instrumental data. The aim is to provide a valuable contribution to the study of the clinical phenotype of Rett and the identification of early interventions. conditions: Rett Syndrome studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Diagnostic test and behavioral measure: Age at diagnosis measure: Mutation in MECP2 measure: Neuroscope alterations measure: Electroencephalogram (EEG) alterations measure: Brain magnetic resonance imaging (MRI) alteration measure: Bone densitometry alterations measure: Thoracic radiographic alterations measure: Lumbosacral spine radiographic alterations measure: Clinical Global Impression (CGI) scale measure: The Rett Syndrome Behavioural Questionnaire (RSBQ) measure: Alterations of neurovisual functions measure: Possibility of applying alternative forms of communication to verbal communication sex: FEMALE minimumAge: 0 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Trinity College Institute of Neuroscience, Lloyd Building, D2 status: RECRUITING city: Dublin country: Ireland name: Daniela Tropea role: CONTACT email: daniela.tropea@tcd.ie lat: 53.33306 lon: -6.24889 facility: Ospedale Versilia Centro di Riferimento status: RECRUITING city: Lido Di Camaiore state: Lucca zip: 55049 country: Italy name: Ilaria Gemo role: CONTACT email: ilaria.gemo@uslnordovest.toscana.it lat: 43.90012 lon: 10.2269 facility: IRCCS Fondazione Stella Maris status: RECRUITING city: Calambrone state: Pisa zip: 56128 country: Italy name: Roberta Battini role: CONTACT phone: 050886282 email: rbattini@fsm.unipi.it lat: 43.58333 lon: 10.3 facility: AOU Meyer status: RECRUITING city: Firenze zip: 50139 country: Italy name: Viola Doccini role: CONTACT email: viola.doccini@meyer.it lat: 43.77925 lon: 11.24626 hasResults: False