hackint0sh/New-Dataset huggingface dataset:
The aim of this study is to study the effectiveness of incorporating music on pain intensity and mobility with the standard postoperative rehabilitation care of fragility hip fracture in Queen Elizabeth Hospital. conditions: Hip Fractures studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 60 type: ESTIMATED name: music listening measure: Pain intensity measured by 11-point pain intensity numerical rating scale after music listening in postoperative Day 1 - 2 among subjects with fragility hip fracture measure: Modified functional ambulatory classification (MFAC) in postoperative Day 3 among subjects with fragility hip fracture measure: New mobility score (NMS) in postoperative Day 3 among subjects with fragility hip fracture sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT facility: Ward G9, Queen Elizabeth Hospital status: RECRUITING city: Hong Kong country: Hong Kong name: Kwan Yiu Jeffrey Lau role: CONTACT phone: 62017014 email: lky194a@ha.org.hk name: Kwan Yiu Jeffrey Lau role: PRINCIPAL_INVESTIGATOR lat: 22.27832 lon: 114.17469 hasResults: False
nctId: NCT06277089 id: Correction of EOS by casts briefTitle: Curve Correction of Early Onset Scoliosis by Mehta Serial Casts overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-09-01 date: 2024-02-26 date: 2024-02-26 name: Assiut University class: OTHER briefSummary: Assessment of the role of Mehta Serial Casts in Curve Correction of Early Onset Scoliosis conditions: Scoliosis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 5 type: ESTIMATED name: Casts measure: Difference of the scoliotic cobb angle at last cast sex: ALL minimumAge: 3 Years maximumAge: 10 Years stdAges: CHILD hasResults: False
nctId: NCT06277076 id: FMD1234 briefTitle: Accuracy of Computer- Guided Implant Surgery in Partially Edentulous Patients. overallStatus: COMPLETED date: 2023-01-28 date: 2023-05-02 date: 2023-08-15 date: 2024-02-26 date: 2024-02-26 name: Saint-Joseph University class: OTHER briefSummary: The dental implant placed freehand with a digital planing is vastly increasing. The accuracy between the planned and the placed implants still not well determined. Between a single implant and a full mouth rehabilitation, the precision is very wide. A precision scale must be settled according to each indication in order to offer the clinician a safety and a predictability for his procedures. conditions: Dental Implant conditions: Computer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 13 type: ACTUAL name: Computer Implant guided Surgery measure: Assess Accuracy of Implant Placement in Vertical Displacement (VD). measure: Assess Accuracy of Implant Placement in Horizontal Displacement (HD) measure: Assess Accuracy of Implant Placement in Error Depth (ED) measure: Assess Accuracy of Implant Placement in Error Angle (EA) measure: Evaluate Precision of the Printed Guide measure: Study Complications and Adverse Events sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Saint Joseph University of Beirut/Dental school city: Beirut zip: 1107 2180 country: Lebanon lat: 33.88894 lon: 35.49442 hasResults: False
nctId: NCT06277063 id: NFEC-2024-057 briefTitle: nVNS for the Prevention and Treatment of Primary Headache overallStatus: NOT_YET_RECRUITING date: 2024-03-10 date: 2026-08-31 date: 2026-12-30 date: 2024-02-26 date: 2024-03-13 name: Nanfang Hospital, Southern Medical University class: OTHER name: BrainClos Co., LTD. name: Zhuhai Fudan Innovation Institute briefSummary: This study is a single-center, randomized, double-blind controlled study. Patients will be randomly assigned to two groups by envelope drawing. The subjects will be divided into two groups: the acute intervention group and the preventive intervention group. In each group, the subjects will be randomly divided into the experimental group and the control group by means of envelope extraction.
Children and adolescents (7-20 years old) with migraine who met the inclusion criteria will be enrolled as subjects in the experimental group, and the changes in headache scores before and after the intervention will be compared. The intervention method is as follows: ictal intervention, in which subjects will be evaluated for headache improvement after a short intervention during an acute exacerbation. By wearing a vagus stimulator, the stimulating electrode will be located in the concha region rich in vagus nerve fiber endings, and the appropriate stimulation intensity will be adjusted for stimulation. Therefore, this study will verify the effect of nVNS on the acute attack and preventive treatment of primary headache in children and adolescents. Based on the electrocardiogram and electromyography indicators during the intervention process of nVNS, an objective evaluation system for the improvement of headache by nVNS is established, and the role of stimulation parameters on the effect is further explored to realize the optimization of parameters. conditions: Primary Headache conditions: Migraine in Adolescence conditions: Migraine in Children conditions: Cluster Headache conditions: Tension Headache studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 288 type: ESTIMATED name: Transcutaneous auricular vagus nerve stimulation name: Sham transcutaneous auricular vagus nerve stimulation measure: Visual analogue scales(VAS)-actue period measure: Visual analogue scales(VAS)-prevention period measure: Heart rate variability(HRV) measure: Electromyography(EMG) sex: ALL minimumAge: 7 Years maximumAge: 20 Years stdAges: CHILD stdAges: ADULT facility: Nanfang Hospital, Southern Medical University city: Guangzhou state: Guangdong country: China name: Ji Ya-Bin, post-doc role: CONTACT phone: +8615913186246 email: yabinji@126.com lat: 23.11667 lon: 113.25 typeAbbrev: Prot_SAP_ICF hasProtocol: True hasSap: True hasIcf: True label: Study Protocol, Statistical Analysis Plan, and Informed Consent Form: Study Protocol date: 2024-02-03 uploadDate: 2024-03-06T22:03 filename: Prot_SAP_ICF_002.pdf size: 158671 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form: Informed Consent Form date: 2024-02-03 uploadDate: 2024-03-06T22:01 filename: ICF_003.pdf size: 139248 hasResults: False
nctId: NCT06277050 id: NPC-ICMB briefTitle: Maintenance Therapy With Toripalimab and Capecitabine Versus Capecitabine Alone in High-risk Nasopharyngeal Carcinoma overallStatus: NOT_YET_RECRUITING date: 2024-03-07 date: 2029-02-20 date: 2030-02-20 date: 2024-02-26 date: 2024-03-07 name: Jiangxi Provincial Cancer Hospital class: OTHER briefSummary: N3 classification, rENE positivity is a high-risk type of locally advanced nasopharyngeal carcinoma. EBV DNA remaining at detectable levels after induction chemotherapy is also a characteristic of high-risk nasopharyngeal carcinoma. Based on the available evidence, patients with high-risk nasopharyngeal carcinoma are recommended to receive oral maintenance therapy to reduce the risk of failure.
The purpose of this study was to conduct a prospective, multicenter, randomized phase III clinical trial to determine whether maintenance therapy with triprilimab combined with capecitabine is better than maintenance therapy with capecitabine alone in high-risk nasopharyngeal carcinoma (N3+, rENE+, Detectable EBV DNA after 2 cycles of induction chemotherapy). conditions: Nasopharyngeal Carcinoma conditions: High-Risk Cancer conditions: Maintenance Therapy studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 264 type: ESTIMATED name: Maintenance Therapy with Toripalimab and Capecitabine name: Maintenance Therapy with Capecitabine measure: Progression-free Survival measure: Distant Metastasis-Free Survival measure: Overall Survival measure: Loco-Regional Recurrence-Free Survival sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06277024 id: FUGES-32 briefTitle: A Study on the Safety and Efficacy of the Combination of Candenizumab, Lenvatinib, and SOX Regimen in the Treatment of HER2 Negative Advanced Gastric or Gastroesophageal Junction Adenocarcinoma Patients overallStatus: RECRUITING date: 2023-01-01 date: 2024-12-31 date: 2027-12-31 date: 2024-02-26 date: 2024-02-26 name: Fujian Medical University class: OTHER briefSummary: Evaluate the objective response rate (ORR) of the combination of candenizumab, lenvatinib, and SOX regimen for the treatment of HER2 negative advanced gastric or gastroesophageal junction adenocarcinoma patients conditions: Overall Response Rate studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: Combination of Cardonizumab with Lenvatinib and SOX regimen measure: ORR sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Gastric Surgery， Fujian Medical University Union Hospital status: RECRUITING city: Fuzhou state: Fujian country: China name: Changming Huang, MD role: CONTACT phone: +8613805069676 email: hcmlr2002@163.com lat: 26.06139 lon: 119.30611 hasResults: False
nctId: NCT06277011 id: Meta10-19-004 briefTitle: Safety and Efficacy of Metabolically Armed CD19 CAR-T Cells (Meta10-19) in the Treatment of Relapsed and/or Refractory CD19-positive B Cell Hematological Malignancies Clinical Research overallStatus: RECRUITING date: 2023-02-10 date: 2025-02-01 date: 2025-05-15 date: 2024-02-26 date: 2024-02-26 name: Anhui Provincial Hospital class: OTHER_GOV name: Leman Biotech Co., Ltd briefSummary: A Study of Metabolically Armed CD19 CAR-T Cells Therapy for Patients With Relapsed and/or Refractory CD19-positive B cell Hematological Malignancies conditions: Acute Lymphoblastic Leukemia conditions: Non-hodgkin Lymphoma studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 18 type: ESTIMATED name: Metabolically Armed CD19 CAR-T cells measure: MTD measure: Objective response rate (ORR) measure: Concentration of CAR-T cells measure: Pharmacodynamics of CAR-T cells sex: ALL minimumAge: 3 Years maximumAge: 70 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Anhui Provincial Hospital status: RECRUITING city: Hefei state: Anhui zip: 518000 country: China name: Xingbing Wang, PhD role: CONTACT phone: +8613856007984 email: wangxingbing@ustc.edu.cn lat: 31.86389 lon: 117.28083 hasResults: False
nctId: NCT06276998 id: LK001304 briefTitle: A Study of LNK01001 Capsule in Subjects With Active Rheumatoid Arthritis overallStatus: RECRUITING date: 2023-12-12 date: 2025-08-04 date: 2026-11-20 date: 2024-02-26 date: 2024-03-22 name: Lynk Pharmaceuticals Co., Ltd class: INDUSTRY briefSummary: Brief Summary: This is a randomized, double-blind study comparing LNK01001 to placebo in Chinese participants with moderately to severely active rheumatoid arthritis who are on a stable dose of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and have an inadequate response or Intolerance to biologic DMARDs(bDMARDs).
The study objective of Period 1 (Day 1 to Week 24) is to compare the safety and efficacy of LNK01001 12 mg twice daily (BID) versus placebo for the treatment of signs and symptoms of participants with moderately to severely active rheumatoid arthritis (RA) who are on a stable dose of csDMARDs and had an inadequate response to or intolerance to at least 1 bDMARD.
The study objective of Period 2 (Week 24 to Week 76) is to evaluate the long-term safety, tolerability, and efficacy of LNK01001 12 mg BID in participants with RA who completed Period 1. conditions: Rheumatoid Arthritis studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 430 type: ESTIMATED name: LNK01001 name: Placebo measure: Percentage of Participants With an American College of Rheumatology 20% (ACR20) Response at Week 24 measure: Change from Baseline in Disease Activity Score 28 (DAS28) (CRP) at week 24 measure: Percentage of Participants with an American College of Rheumatology 50% (ACR50) Response at week 24 measure: Change from Baseline in Health Assessment Questionnaire - Disability Index (HAQ-DI) at all visits. measure: Percentage of Participants with an American College of Rheumatology 70% (ACR70) Response at all visits. measure: Percentage of Participants Achieving Low Disease Activity (LDA) Based on DAS28(CRP) at all visits. measure: Percentage of Participants Achieving Clinical Remission (CR) Based on DAS28(CRP) at all visits measure: Percentage of Participants with an American College of Rheumatology 20% (ACR20) Response at all visits (except week 24). measure: Change from Baseline in the Severity of Morning Stiffness at all visits. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking Union Medical College Hospital status: RECRUITING city: Beijing country: China name: Xiaofeng Zeng role: CONTACT phone: 0086-010-69158793 email: xiaofeng.zeng@cstar.org.cn lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06276985 id: 977/91 briefTitle: Impact of Injectable Platelet Rich Fibrin Versus Low-intensity Pulsed Ultrasound on Different Orthodontic Tooth Movements During Clear Aligner Therapy overallStatus: ENROLLING_BY_INVITATION date: 2024-02-25 date: 2024-06-25 date: 2024-07-25 date: 2024-02-26 date: 2024-02-26 name: Al-Azhar University class: OTHER briefSummary: The aim of this prospective clinical project will be to compare the effect of platelet rich fibrin versus low- intensity pulsed ultrasound on therate of different orthodontic tooth movements during clear aligner therapy. conditions: Effect of Platelet Rich Fibrin Versus Low Intensity Pulsed Ultrasound During Clear Aligner Therapy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: BASIC_SCIENCE masking: NONE count: 82 type: ESTIMATED name: low intensity pulsed ultrasound and iPRF measure: Influence of low-level laser therapy versus low-intensity pulsed ultrasound on rate of different orthodontic tooth movements by millimeter sex: ALL minimumAge: 15 Years maximumAge: 22 Years stdAges: CHILD stdAges: ADULT facility: AlAzhar university city: Cairo country: Egypt lat: 30.06263 lon: 31.24967 hasResults: False
nctId: NCT06276972 id: P.T.REC/012/005000 briefTitle: Relationship Between Spine Coronal Alignment and Lower Limb Biomechanical in Scoliosis overallStatus: ACTIVE_NOT_RECRUITING date: 2023-03-12 date: 2024-03-01 date: 2024-03-15 date: 2024-02-26 date: 2024-02-26 name: Delta University for Science and Technology class: OTHER name: Benha University briefSummary: To examine the relationships between spine coronal alignment and lower limb biomechanical parameters in scoliotic adolescents conditions: Scoliosis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 89 type: ACTUAL name: no intervention measure: Cobb's angle measure: Coronal balance measure: length of the the tibia and femur measure: tibiofemoral angle measure: knee joint line convergence angle measure: lower limb mechanical axis; and mechanical axis deviation sex: ALL minimumAge: 10 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Delta university for science and technology city: Gamasa state: Dakahleya zip: 7731168 country: Egypt lat: 31.44112 lon: 31.53675 hasResults: False
nctId: NCT06276959 id: WCHSIRB-D-2022-430 briefTitle: The Effectiveness of iTero Element 5D NIRI System in Early Proximal Caries Detection in Permanent Teeth overallStatus: RECRUITING date: 2023-01-01 date: 2025-03-01 date: 2025-03-01 date: 2024-02-26 date: 2024-04-12 name: West China College of Stomatology class: OTHER briefSummary: As a new emerging technology for the diagnosis of dental caries, near-infrared imaging requires further research and validation to determine its effectiveness. This study aims to compare near-infrared imaging with cone-beam computed tomography (CBCT) to validate the efficiency of near-infrared imaging in diagnosing proximal caries using large-scale clinical data through retrospective cross-sectional studies. conditions: Dental Caries studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 120 type: ESTIMATED name: intraoral scanning name: clinical oral examination name: cone-beam computed tomography measure: positive percent agreement measure: negative percent agreement measure: overall percent agreement measure: Proximal caries positive site diagnosed by CBCT measure: Proximal caries positive site diagnosed by near-infrared imaging (NIRI) measure: Proximal caries positive site diagnosed by unaided visual examination (UVE) sex: ALL minimumAge: 12 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: West China Hospital of Stomatology, Sichuan University status: RECRUITING city: Chengdu state: Sichuan zip: 610041 country: China name: Zhihe Zhao, Doctor role: CONTACT phone: +86 139 8188 1666 email: zhzhao@scu.edu.cn lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06276946 id: LCCC2244 briefTitle: Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia overallStatus: NOT_YET_RECRUITING date: 2024-05-08 date: 2028-07 date: 2029-01 date: 2024-02-26 date: 2024-03-22 name: UNC Lineberger Comprehensive Cancer Center class: OTHER briefSummary: Radiation-induced xerostomia (dry mouth) is one of the most common and severe toxicities experienced by patients undergoing radiation treatment for head and neck cancer. Radiation-induced dry mouth is a frequently experienced symptom and persists after treatment, potentially indefinitely. Current practice does not specifically attempt to spare the parotid ducts, where stem/progenitor cells are believed to preferentially reside, and considers the entire salivary gland to have equal function. New radiation therapy planning and conducting strategies are needed to reduce this toxicity and maximize patient quality of life post-treatment.
This randomized Phase II study explores the contribution of magnetic resonance imaging (MRI) guided salivary gland duct definition to decrease patient-reported xerostomia in patients with oropharynx cancer receiving radiation therapy. The severity of xerostomia will be measured by patient-reported (PRO) symptoms, saliva secretion, saliva pH, and buffering. conditions: Oropharynx Cancer conditions: Head and Neck Cancer conditions: Xerostomia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 98 type: ESTIMATED name: standard radiotherapy name: experimental radiotherapy measure: The difference in patient-reported xerostomia 6 months measure: Saliva mass measure: Parotid duct dose constraint measure: The difference in patient-reported xerostomia 12 months measure: Xerostomia by NCI-CTCAE sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of North Carolina at Chapel Hill, Department of Radiation Oncology city: Chapel Hill state: North Carolina zip: 27599 country: United States lat: 35.9132 lon: -79.05584 hasResults: False
nctId: NCT06276933 id: MA-NSCLC-II-039 briefTitle: A Study of Camrelizumab Combined With Chemotherapy ± Thalidomide in First-line Treatment of Patients With Advanced Non-small Cell Lung Cancer (NSCLC) overallStatus: NOT_YET_RECRUITING date: 2024-02-22 date: 2025-11-22 date: 2026-11-22 date: 2024-02-26 date: 2024-02-26 name: Tongji University class: OTHER name: Shanghai Pulmonary Hospital, Shanghai, China briefSummary: To explore and evaluate the safety and efficacy of camrelizumab combined with chemotherapy ± thalidomide in first-line treatment of advanced non-small cell lung cancer patients conditions: Lung Cancer conditions: Camrelizumab studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 104 type: ESTIMATED name: Camrelizumab + chemotherapy+Thalidomide name: Camrelizumab + chemotherapy+placebo measure: Incidence rate of any grade Reactive Cutaneous Capillary Endothelial Proliferation(RCCEP) measure: Median time to RCCEP measure: Median time to RCCEP of level 3 or above measure: Incidence rate of ≥G3 grade RCCEP measure: Overall Response Rate (ORR) measure: Progression-Free Survival (PFS) measure: Overall Survival(OS) measure: Treatment-related Adverse Events (TRAE) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06276920 id: 2024/5554(1) briefTitle: Evaluation of Joint Position Sense in Healthy Individuals overallStatus: RECRUITING date: 2024-02-07 date: 2024-02-29 date: 2024-02-29 date: 2024-02-26 date: 2024-02-26 name: Inonu University class: OTHER briefSummary: It was aimed to measure the elbow joint position sense in healthy individuals in the case of a closed kinetic chain and to compare it with the measurement made in the case of an open kinetic chain. conditions: Proprioception studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 4 type: ESTIMATED measure: Joint position sense measurement with universal goniometer in close kinetic chain measure: Joint position sense measurement with universal goniometer in open kinetic chain sex: ALL minimumAge: 18 Years maximumAge: 25 Years stdAges: ADULT facility: Inonu University status: RECRUITING city: Malatya zip: 12000 country: Turkey name: DILAN DEMİRTAŞ KARAOBA role: CONTACT phone: 0554112779 email: dilandemirtas92@gmail.com lat: 38.35018 lon: 38.31667 hasResults: False