hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06313086 id: SYSA1501-009 id: CTR20240245 type: REGISTRY domain: NMPA briefTitle: DP303c Versus Trastuzumab Emtansine in in Patients With HER2-positive Advanced Breast Cancer overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-12 date: 2028-02 date: 2024-03-15 date: 2024-03-15 name: CSPC ZhongQi Pharmaceutical Technology Co., Ltd. class: INDUSTRY briefSummary: A Clinical Study to Evaluate the Efficacy and Safety of DP303c versus trastuzumab emtansine in patients with HER2-positive Advanced Breast Cancer conditions: HER2-positive Breast Cancer studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Parallel Assignment primaryPurpose: TREATMENT masking: NONE count: 442 type: ESTIMATED name: DP303c name: trastuzumab emtansine measure: Progression-free survival (PFS) by BIRC measure: Progression-free survival (PFS) by investigator measure: Overall Survival (OS) measure: Objective response rate (ORR) measure: Duration of response (DoR) measure: Incidence and severity of adverse events (AEs) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06313073 id: CHFL-BC-01 briefTitle: Neoadjuvant Radiotherapy for Breast Cancer overallStatus: RECRUITING date: 2024-04-01 date: 2026-02-15 date: 2026-02-15 date: 2024-03-15 date: 2024-03-15 name: Changhai Hospital class: OTHER briefSummary: The goal of this clinical trial is to compare the effects of neoadjuvant radiotherapy and adjuvant radiotherapy in patients with breast cancer.
* Evaluate the acute and late toxicity of preoperative radiotherapy Participants will be randomly divided into two groups: the neoadjuvant radiotherapy group and the adjuvant radiotherapy group. conditions: Neoadjuvant Radiotherapy conditions: Breast Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Neoadjuvant radiotherapy name: adjuvant radiotherapy measure: pCR measure: RCB sex: FEMALE minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Changhai hospital status: RECRUITING city: Shanghai state: Shanghai zip: 200433 country: China name: Huojun Zhang, M.D. role: CONTACT phone: +8613311732399 email: chyyzhj@163.com name: Huojun Zhang, M.D. role: PRINCIPAL_INVESTIGATOR lat: 31.22222 lon: 121.45806 hasResults: False
nctId: NCT06313060 id: 010 briefTitle: Efficacy of Carbonated Beverages in the Resolution of Alimentary Esophageal Impaction overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2025-01-01 date: 2027-01-01 date: 2024-03-15 date: 2024-03-15 name: Hospital del Río Hortega class: OTHER briefSummary: Objectives: To evaluate the efficacy of the administration of carbonated beverages in the resolution of dietary esophageal impaction, and to identify subgroups in which their effectiveness may be different: patients with/without esophageal diseases, with/without a history of impaction.
Methods: A clinical trial was conducted randomizing consecutive patients with a clinical diagnosis of dietary esophageal impaction to receive 200cc of carbonated drink or not at all, excluding patients with a previous diagnosis of non-esophageal stenosis that could not be overcome with a gastroscope and suspected impaction by non-alimentary foreign bodies, spines or bones. Subsequently, an endoscopic evaluation will be carried out in all cases, checking the presence or absence of a foreign body and removing it if necessary, as well as assessing and recording the possible underlying esophageal pathology.
A telephone follow-up will be carried out after 7 days, recording possible adverse events. conditions: Esophagus Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized clinical trial primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 354 type: ESTIMATED name: Coca-cola measure: Efficacy of carbonated beverage for disimpaction sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06313047 id: Doxorubacin in HCC briefTitle: Pharmacogenetic of Doxorubicin in HCC. overallStatus: COMPLETED date: 2021-01-01 date: 2023-12-15 date: 2023-12-30 date: 2024-03-15 date: 2024-03-28 name: Rehab Werida class: OTHER name: King Saud Bin Abdulaziz University for Health Sciences name: King Abdullah Bin Abdulaziz University Hospital briefSummary: The study included 81 HCC patients, both male and female. Prior to being assessed for eligibility, each recruited patient with HCC received a comprehensive review of their medical history, physical status, and laboratory results. Every research participant take part in the experiment and provided written informed consent. conditions: Hepatocellular Carcinoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 81 type: ACTUAL name: Doxorubicin measure: GSTP1 measure: CYP2B6 sex: ALL minimumAge: 20 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: King Abdullah bin Abdulaziz University Hospital city: Riyadh country: Saudi Arabia lat: 24.68773 lon: 46.72185 hasResults: False
nctId: NCT06313034 id: GU-SBF-OPA-02 briefTitle: The Effect of Breastfeeding Training Given to Mothers With Vaginal Birth by Motivational Interview Technique overallStatus: RECRUITING date: 2023-05-01 date: 2024-03-15 date: 2024-03-15 date: 2024-03-15 date: 2024-03-15 name: Gümüşhane Universıty class: OTHER name: Karadeniz Technical University briefSummary: This study aimed to determine the effect of breastfeeding education given to mothers who gave birth vaginally using motivational interviewing technique on breastfeeding motivation, self-efficacy and attachment. The study will be conducted as a single-blind, randomized controlled trial. conditions: Breastfeeding studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The sample of the research will consist of mothers who gave primary vaginal birth (40 experimental group and 40 control group) primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: While it is known by the researcher whether the mothers are in the experimental or control group, it is not known by the mother. whoMasked: PARTICIPANT count: 80 type: ESTIMATED name: Breastfeeding education based on motivational interviewing technique measure: Mother Introductory Information Form measure: Primipara Breastfeeding Motivation Scale measure: Breastfeeding Self-Efficacy Scale Short Form measure: Mother-Baby Attachment Scale sex: FEMALE minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Gümüşhane University status: RECRUITING city: Gümüşhane country: Turkey name: ÖZGE PALANCI AY role: CONTACT lat: 40.46001 lon: 39.47176 hasResults: False
nctId: NCT06313021 id: 2023.12.03 briefTitle: Turkish Version of the Brief Assessment of Cognitive Impairment in Individuals With Stroke Scale overallStatus: RECRUITING date: 2024-01-15 date: 2024-04-15 date: 2024-05-15 date: 2024-03-15 date: 2024-03-15 name: Ataturk University class: OTHER briefSummary: Cognitive processing involves many interrelated cognitive domains, such as performing daily tasks, attention, language, and memory. 70% of individuals with stroke experience cognitive problems. Due to cognitive problems, individuals with stroke have difficulty processing and planning information. This situation negatively affects daily living activities and returning to work. Cognitive disorders that occur after stroke negatively affect the functional independence of individuals. At the same time, individuals with stroke have difficulty structuring and organizing information. The individual may not be able to pay sufficient attention during the activity in terms of planning, automatic attention and adaptation to the stages required by the job.
Cognitive evaluation should include cognition, orientation, and higher cortical functions because the cognitive process is a very complex process. Assessment methods frequently used in cognitive evaluation of stroke patients; Scales and tests such as Simple Mental Test, Mini Mental State Test, Montreal Cognitive Assessment Scale, Wechsler Memory and Intelligence Test are used. General problems with these evaluations; Some of them have a long application period, some of them have problems in perception of the patients, and some of them have a low power to distinguish the cognitive problems of the patients. When the Brief Assessment of Cognitive Impairment Scale, a newly introduced scale in the literature, is examined; It attracts attention because the items are very simple for patients to perceive, combine cognitive tests and cognitive questionnaires, have a short application period, and have not shown a ceiling or floor effect in previous studies. For all these reasons, this study was planned to conduct the Turkish validity and reliability study of the Brief Assessment of Cognitive Impairment Scale. conditions: Stroke conditions: Cognition studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 40 type: ESTIMATED name: Reliability and Validity Study measure: Brief Assessment of Cognitive Impairment Scale measure: Mini Mental State Test measure: Sociodemographic Assessment sex: ALL minimumAge: 40 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ataturk University status: RECRUITING city: Erzurum country: Turkey name: Birol Önal, Dr. role: CONTACT phone: +904422311233 email: birol.onal@atauni.edu.tr lat: 39.90861 lon: 41.27694 hasResults: False
nctId: NCT06313008 id: EMBA-VILDA-Response trial. briefTitle: Empagliflozin Versus Vildagliptin in CAD Patients With T2DM overallStatus: RECRUITING date: 2023-08-10 date: 2024-06-01 date: 2024-06-10 date: 2024-03-15 date: 2024-04-16 name: Damanhour University class: OTHER name: Tanta University briefSummary: We compared the cardioprotective effects of empagliflozin, an SGLT2 inhibitor, with those of vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, focusing on various inflammatory biomarkers lipid profile, and cardiac function, in patients with type 2 diabetes mellitus (T2DM). conditions: Coronary Artery Disease conditions: Type 2 Diabetes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This was a prospective, randomized, double-dummy, blinded-endpoint, parallel-group trial that enrolled 120 CAD patients with T2DM. The patients were randomized 1: 1 for 6 months administration of empagliflozin or vildagliptin. primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 120 type: ESTIMATED name: Empagliflozin 10 MG name: Vildagliptin 50 MG measure: LVEF % measure: Sortilin (ng/ml) measure: LDL (mg/dl) measure: hsCRP (mg/L) measure: HbA1c % measure: FBG (mg/dl) sex: ALL minimumAge: 40 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Rehab Hussein Werida status: RECRUITING city: Damanhūr state: Elbehairah zip: 31527 country: Egypt name: Naglaa Khedr, Prof. role: CONTACT email: naglaa.khedr@pharm.tanta.edu.eg name: Lamiaa Khedr, Ass.Prof. role: CONTACT email: lamiaa_khedr@yahoo.com lat: 31.03408 lon: 30.46823 hasResults: False
nctId: NCT06312995 id: T3DDY02 briefTitle: Investigation of a Medical Device for the Immobilisation of Radius and Ulna Fractures in Paediatric Patients acronym: T3DDY02 overallStatus: RECRUITING date: 2022-03-14 date: 2025-02-14 date: 2025-06-14 date: 2024-03-15 date: 2024-03-15 name: Meyer Children's Hospital IRCCS class: OTHER briefSummary: Single-centre, randomised, controlled, non-profit study on a custom-made medical device for immobilisation of radius and ulna fracture in paediatric patients.
The aim of the study is to evaluate the benefits in terms of comfort, safety and efficacy resulting from the use of a customised 3D-printed wrist immobilisation device in children aged between 7 and 13 with a fracture of the distal metaphysis of radius or ulna of the 'green stick' type, compared to a control group treated with traditional immobilisation devices. The patients will be randomised between use of customised 3D- printed wrist immobilisisation device and plaster. conditions: Fractures, Bone studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 40 type: ESTIMATED name: T3DDY01 name: PLASTER measure: Fracture Healing measure: Adverse event measure: Comfort of use of devices measure: Presence of skin lesions or other manifestations of intolerance to the device measure: Pain evaluation measure: Acceptance of the device measure: Structural analysis of devices measure: Usability for design purposes of the controlate sex: ALL minimumAge: 7 Years maximumAge: 13 Years stdAges: CHILD facility: Meyer Children's Hospital IRCCS status: RECRUITING city: Florence zip: 50139 country: Italy name: Alessandro Zanardi, MD role: CONTACT phone: 055 5662908 email: alessadro.zanardi@meyer.it lat: 43.77925 lon: 11.24626 hasResults: False
nctId: NCT06312982 id: BFH-niCRT-04 briefTitle: A Series of Neoadjuvant Chemoradiotherapy Combined With Immunotherapy for Locally Advanced Rectal Cancer: From a Multicenter Phase II Cohort to a Phase III Randomized Controlled Study overallStatus: RECRUITING date: 2024-02-20 date: 2026-12 date: 2026-12 date: 2024-03-15 date: 2024-03-15 name: Beijing Friendship Hospital class: OTHER name: Beijing Chao Yang Hospital name: Peking University Cancer Hospital & Institute name: CHINA-JAPEN FRIENDSHIP HOSPITAL name: Peking Union Medical College Hospital name: Cancer Institute and Hospital, Chinese Academy of Medical Sciences name: Fudan University name: Changhai Hospital name: RenJi Hospital name: Sir Run Run Shaw Hospital, affiliated with the Zhejiang University School of Medicine name: Shandong Provincial Hospital name: Zhongnan Hospital of Wuhan University & Second Clinical Hospital of Wuhan University name: The First Affiliated Hospital of Zhengzhou University name: West China School of Medicine and West China Hospital, Sichuan University name: Sichuan Academy of Medical Sciences name: The Sixth Affiliated Hospital, Sun Yat-sen University name: The First Hospital of Jilin University name: First Hospital of China Medical University name: Army Medical Center of PLA name: The First Affiliated Hospital of Anhui Medical University briefSummary: The goal of this clinical trial is to compare the efficacy and safety of neoadjuvant chemoradiotherapy combined with tirelizumab compared with neoadjuvant chemoradiotherapy alone for neoadjuvant therapy in patients with locally advanced rectal cancer.
To evaluate the efficacy and safety of neoadjuvant chemoradiotherapy combined with tirelizumab compared with neoadjuvant chemoradiotherapy alone for neoadjuvant therapy in patients with locally advanced rectal cancer To assess rectal or anal retention as well as quality of life. Participants will receive a long course of NCRT (50 Gy / 25f, capecitabine 850-1000 mg / m2, BID, PO, D1-D5, QW) within the first 5 weeks. In regard to tumor immunotherapy, enrolled patients will receive tislelizumab (200 mg, iv) on the first day at week 2,5, and 8 after initiation of radiotherapy. Thereafter, patients will be treated with two 14-day cycles of the CAPOX（Q 3 w; D1 oxaliplatin, 130mg/m2,iv.gtt; D1-D14, capecitabine, 850-1000mg / m2, BID, PO）regimen. Two CAOPX regimens were treated one week apart. conditions: Locally Advanced Rectal Carcinoma studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 375 type: ESTIMATED name: Tislelizumab measure: CR measure: AE rate measure: NAR score measure: ORR measure: OPR measure: immune-related adverse event rate sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beijing Friendship Hospital, Capital Medical University status: RECRUITING city: Beijing state: Beijing zip: 100050 country: China name: Yao Hongwei, M.D role: CONTACT phone: 86 13611015609 email: yaohongwei@ccmu.edu.cn lat: 39.9075 lon: 116.39723 facility: Beijing Friendship Hospital status: RECRUITING city: Beijing state: Beijing zip: 100050 country: China name: Zhongtao Zhang,, MD role: CONTACT phone: +86-13801060364 email: zhangzht@ccmu.edu.cn lat: 39.9075 lon: 116.39723 hasResults: False
nctId: NCT06312969 id: 2022.301 briefTitle: Technological Gaming in Cancer Survivors (WINNERS) acronym: WINNERS overallStatus: RECRUITING date: 2023-02-23 date: 2024-09 date: 2025-02 date: 2024-03-15 date: 2024-03-15 name: Antonio Pérez Martínez class: OTHER name: Hospital Ruber Internacional name: Universidad Rey Juan Carlos briefSummary: HYPOTHESIS
POPULATION OF THE STUDY The target population participating in the study will include patients of either sex aged 8-17 years who completed cancer treatment 1-5 years ago. They must have received treatment with neurotoxic potential: intrathecal/intraventricular chemotherapy, high-dose chemotherapy with crossing of the blood-brain barrier, CNS radiotherapy or hematopoietic stem cell transplantation (HSCT). conditions: Survivors of Childhood Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized versus control group clinical trial. primaryPurpose: TREATMENT masking: NONE count: 56 type: ESTIMATED name: Video game based training measure: SDMT Test measure: Change in SDMT Test measure: Change in SDMT Test measure: "DIGITOS" Test measure: Change in "DIGITOS" Test measure: Change in "DIGITOS" Test measure: "TONI-4" test measure: Change in "TONI-4" test measure: Change in "TONI-4" test measure: "ROCF" test measure: Change in "ROCF" test measure: Change in "ROCF" test measure: "TFV" test measure: Change in "TFV" test measure: Change in "TFV" test measure: "STROOP" test measure: Change in "STROOP" test measure: Change in "STROOP" test measure: "TAVECI" test measure: Change in "TAVECI" test measure: Change in "TAVECI" test measure: "CPT3" measure: Change in "CPT3" measure: Change in "CPT3" measure: "BRIEF" survey measure: Change in "BRIEF" survey measure: Change in "BRIEF" survey measure: "BASC" survey measure: Change in "BASC" survey measure: Change in "BASC" survey measure: Statistically significant changes in neuroimaging tests measure: Statistically significant changes in neuroimaging tests measure: Immune and inflammatory biomarkers measure: Statistically significant changes in immune and inflammatory biomarkers measure: Statistically significant changes in immune and inflammatory biomarkers measure: Prevalence measure: Perception of the family measured by satisfaction survey sex: ALL minimumAge: 8 Years maximumAge: 17 Years stdAges: CHILD facility: Hospital La Paz status: RECRUITING city: Madrid zip: 28046 country: Spain name: Carlos Gonzalez-Perez, MD role: CONTACT phone: 0034917277223 email: carlos.gonzalez2@salud.madrid.org name: Antonio Perez-Martinez, PhD, MD role: PRINCIPAL_INVESTIGATOR name: Carlos R Gonzalez-Perez, MD role: SUB_INVESTIGATOR name: Eduardo Fernandez, PhD role: SUB_INVESTIGATOR name: Elena Moran role: SUB_INVESTIGATOR name: Juan Alvarez role: SUB_INVESTIGATOR name: Norberto Malpica role: SUB_INVESTIGATOR name: Diego Plaza, MD role: SUB_INVESTIGATOR name: Mario Alonso role: SUB_INVESTIGATOR lat: 40.4165 lon: -3.70256 hasResults: False
nctId: NCT06312956 id: 21C403 briefTitle: Multidimensional Evaluation of Patients' Affected by Obstructive Apnea Syndrome (OSAS) Before and After Ventilotherapy acronym: MULTI-OSAS overallStatus: RECRUITING date: 2024-02-29 date: 2025-06 date: 2026-02 date: 2024-03-15 date: 2024-03-15 name: Istituto Auxologico Italiano class: OTHER briefSummary: This observational study aims to evaluate multiple dimensions of health in patients with Obstructive Sleep Apnea Syndrome (OSAS), before and after three weeks of ventilotherapy.
* psychosocial self-reported questionnaires conditions: Obstructive Sleep Apnea conditions: Sleep Disorder conditions: Well-Being, Psychological conditions: Cognitive Impairment conditions: Cognitive Change conditions: Neurologic Signs studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 65 type: ESTIMATED name: Continuous Positive Airway Pressure Ventilotherapy measure: Overall cognitive functioning measure: Selective attention measure: Memory and learning measure: Visuo-spatial abilities measure: Inhibition measure: Planning measure: Decision making measure: biomarkers of neurodegeneration measure: psychosocial wellbeing and satisfaction measure: Quality of life (perceived psycho-physical and socio-economic wellbeing and satisfaction) sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: IRCCS Istituto Auxologico Italiano status: RECRUITING city: Piancavallo state: VCO zip: 28824 country: Italy name: Sofia Tagini, PhD role: CONTACT phone: 00393339915288 email: s.tagini@auxologico.it hasResults: False
nctId: NCT06312943 id: APHP180414 id: 2022-A02170-43 type: OTHER domain: France : Ministry of Health briefTitle: "Translating Articular Biomarkers Into Diagnoses" acronym: ARTBioSes overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2027-09 date: 2024-03-15 date: 2024-03-15 name: Assistance Publique - Hôpitaux de Paris class: OTHER name: Institut National de la Santé Et de la Recherche Médicale, France briefSummary: Early diagnosis is a key factor in the prevention and management of rheumatic diseases. Rheumatic diseases are classically diagnosed based on criteria combining clinical, biological and radiological features. However, in up to 20% of the cases, diagnoses remain unstated and underlying rheumatic diseases unclassified, which might lead to delayed specific treatment and unfavourable clinical outcomes. In addition, conventional methods could lack sensitivity and specificity for early diagnosis. Biological samples are attractive targets for the early detection of articular damage because they allow for collection of multiple levels of information from the clinic and the laboratory\]. Biological samples most frequently collected from patients with rheumatic diseases are synovial fluid by joint aspiration, blood by venous puncture and tissue specimen by surgery. The investigators hypothesize that in challenging situations, novel biomarkers detected from synovial fluid or articular tissues using both conventional (e.g. histology, immunodetection, PCR) and innovative (e.g. Raman spectroscopy, nanospectroscopy) laboratory tests may help refining diagnosis and better classifying patients with rheumatic diseases. conditions: Inflammatory and Non-inflammatory Bone and Joint Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: Collection of joint fluid or tissue sample measure: Tissues and biofluid spectra using surface-enhanced Raman spectroscopy measure: Protein expression using immunodetection techniques and RNA expression using PCR measure: Tissues and biofluid spectra using surface-enhanced Raman spectroscopy measure: Protein expression using immunodetection techniques and RNA expression using PCR sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Service de Médecine Physique et de Réadaptation, Hôpital Cochin city: Paris state: IDF zip: 75014 country: France name: Christelle Nguyen, MD, PhD role: CONTACT phone: 00 33 1 58 41 29 45 email: christelle.nguyen2@aphp.fr name: MD, PhD role: CONTACT name: François Rannou, MD, PhD role: SUB_INVESTIGATOR name: Didier Borderie, MD, PhD role: SUB_INVESTIGATOR lat: 48.85341 lon: 2.3488 hasResults: False