hackint0sh/New-Dataset huggingface dataset:
nctId: NCT06344221 id: 2023-A00954-41 briefTitle: Post-stroke Haptic Feedback Use Deficit: A Comparative and Reliability Study acronym: HapticS overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-07-15 date: 2024-07-15 date: 2024-04-03 date: 2024-04-03 name: Centre Hospitalier St Anne class: OTHER name: Brain & Spine Institute (ICM) name: Centre Hospitalier Régional d'Orléans briefSummary: The aim of this comparative and reliability study is to highlight a deficit in the use of vibrotactile sensory feedback (haptic effect) in the planning and execution of fine manual dexterity movements after stroke. The investigators will include 3 groups of subjects, 1 group of young healthy subjects, 1 of older subjects matched in age and sex to the group of chronic stroke patients. Participants will take part in clinical tests of fine motor skills and sensitivity and will use a device to assess the key components of manual dexterity, to which vibrotactile sensors will be added. If they so wish, participants will be able to take part in a transcranial magnetic stimulation (TMS) study to assess the facilitation of cortical excitability due to the haptic effect. conditions: Stroke conditions: Upper Extremity Paresis conditions: Manual Dexterity conditions: Sensory Integration Dysfunction conditions: Vibration; Disorder studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 90 type: ESTIMATED name: Dextrain Manipulandum and haptic feedback device measure: Assessing haptic effect during a dexterity exercise with and without sensory feedback: finger independence measure: Assessing haptic effect during another dexterity exercise with and without sensory feedback: the force control of the index measure: Assessing haptic effect during another dexterity exercise with and without sensory feedback: the rhythm capacity measure: Correlation between clinical assessment and haptic measure measure: Assessment of the feasibility of the haptic measures measure: Assessment of the benefits of the haptic measures measure: Study the test re-test reliability of the haptic device by comparing the haptic effect on dexterity assessed at the beginning and end of the session by the same evaluator measure: Assessment of the impact of age on the dexterity performances (Finger independence, force control of the index and rhythm capacity) measure: Measurement of the manual dexterity facilitation between tactile (haptic device with vibrations on the fingers) and auditory feedback (sounds during the dexterity tasks) measure: Transcranial magnetic stimulation (TMS) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
nctId: NCT06344208 id: IEO 1647 briefTitle: Predicting Toxicity in Elderly Patients With Head and Neck Cancer acronym: PREtoxEL overallStatus: RECRUITING date: 2022-03-15 date: 2024-12-31 date: 2024-12-31 date: 2024-04-03 date: 2024-04-03 name: European Institute of Oncology class: OTHER briefSummary: Predicting toxicity in elderly patients with head and neck cancer:
validating a disease-oriented toxicity predictive tool and integrating it with avail-able screening tools for better outcomes. conditions: Head and Neck Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 3 type: ESTIMATED measure: Predicting toxicity in elderly patients with head and neck cancer sex: ALL minimumAge: 70 Years maximumAge: 99 Years stdAges: OLDER_ADULT facility: European Institute of Oncology status: RECRUITING city: Milan state: MI zip: 20141 country: Italy name: maria Cossu Rocca, MD role: CONTACT phone: 00390294372900 email: maria.cossurocca@ieo.it lat: 45.46427 lon: 9.18951 hasResults: False
nctId: NCT06344195 id: 2517 briefTitle: Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber Opening acronym: Antiviral overallStatus: RECRUITING date: 2024-03-27 date: 2024-04 date: 2024-05 date: 2024-04-03 date: 2024-04-10 name: Dow University of Health Sciences class: OTHER briefSummary: This study is aimed to evaluate the efficacy of valacyclovir in reducing postoperative pain following emergency chamber opening for acute apical abscess .
There will be 82 participants, (41 in each group) Group A will receive Valacyclovir Group B will receive standard treatment i.e. Naproxen Sodium. Pain level will be assessed by using Numeric rating scale for 6 days conditions: Acute Apical Abscess studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 82 type: ESTIMATED name: Valacyclovir 500 mg name: Naproxen Sodium 550mg measure: Changes in pain score using Numeric Rating Scale (NRS) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Dr. Yumna Shaheen Ali status: RECRUITING city: Karachi state: Sindh zip: 75290 country: Pakistan name: Dr. Yumna Shaheen Ali role: CONTACT email: yumna.shaheen@duhs.edu.pk lat: 24.8608 lon: 67.0104 hasResults: False
nctId: NCT06344182 id: STarkan briefTitle: Reliability, Concurrent Validity and Minimal Detectable Change of the Step Up and Down Test in Patients With Total Knee Arthroplasty overallStatus: COMPLETED date: 2021-02-01 date: 2021-05-15 date: 2021-05-15 date: 2024-04-03 date: 2024-04-03 name: Dokuz Eylul University class: OTHER briefSummary: The aim of the study is to measure the validity and reliability of the StUD test in patients with TKA. Forty-seven patients with primary TKA included in this study. The test-retest reliability of the StUD test was measured with 1-hour interval. Validity was assessed that the 30s Chair Stand Test (30sCS), the Hospital for Special Surgery score (HSS) and Short Form-12 Quality Life Questionnaire (SF-12) were used as comparator instruments. conditions: Total Knee Arthroplasty studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 47 type: ACTUAL name: Step Up and Down Test measure: Step Up and Down Test measure: 30 Seconds Chair Stand Test measure: Hospital for Special Surgery (HSS) Knee Score measure: 12-Item Short-Form Health Survey sex: ALL minimumAge: 40 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Dokuz Eylul University city: Izmir country: Turkey lat: 38.41273 lon: 27.13838 hasResults: False
nctId: NCT06344156 id: PDAC-Neoantigen briefTitle: Neoantigen Vaccine Plus Anti-PD1 and Chemotherapy as an Adjuvant Therapy for Pancreatic Cancer overallStatus: RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2027-04-01 date: 2024-04-03 date: 2024-04-03 name: Sichuan University class: OTHER briefSummary: The aim of this single center, single arm and prospective study is to explore the safety and efficacy of Neoantigen Vaccine Plus Anti-PD1 and Chemotherapy in postoperative adjuvant treatment of Pancreatic Cancer conditions: Pancreatic Cancer conditions: Adjuvant Therapy studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 43 type: ESTIMATED name: Neoantigen Vaccine Plus Anti-PD1 and Chemotherapy measure: 18-month RFS measure: Incidence of Treatment-Related Adverse Events [Safety and Tolerability] measure: 18-month OS sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: West China Hospital, Sichuan University status: RECRUITING city: Chengdu state: Sichuan zip: 610000 country: China name: Zhong Wu, MD role: CONTACT phone: 028-85422851 email: wuzhong5555@126.com name: Zhong Wu role: PRINCIPAL_INVESTIGATOR lat: 30.66667 lon: 104.06667 hasResults: False
nctId: NCT06344143 id: 24-324 briefTitle: Detecting Mild Autonomous Cortisol Secretion in Patients With Adrenal Incidentaloma acronym: MACS overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2029-11-01 date: 2030-12-31 date: 2024-04-03 date: 2024-04-26 name: The Cleveland Clinic class: OTHER name: Recordati Rare Diseases briefSummary: The aim of the proposed study is to estimate the incidence of Mild Autonomous Cortisol Secretion (MACS) in patients with Adrenal Incidentaloma (AI) and evaluate the available diagnostic tests to determine the most sensitive and specific combination of tests for assessing MACS from adrenal adenoma for prediction of the phenotype associated with cortisol excess. As well as following the patients for 4 years and see if anything changes. conditions: Mild Autonomous Cortisol Secretion (MACS) studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 20 type: ESTIMATED name: Various labs and imaging tests measure: Evaluate best diagnostic test(s) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: The Cleveland Clinic Foundation city: Cleveland state: Ohio zip: 44195 country: United States name: Maya Boyd role: CONTACT phone: 216-444-4919 email: boyda5@ccf.org name: jenkink@ccf.org Jenkins role: CONTACT phone: 216-445-4791 email: jenkink@ccf.org lat: 41.4995 lon: -81.69541 hasResults: False
nctId: NCT06344130 id: 10001859 id: 001859-C briefTitle: Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-12-31 date: 2027-12-31 date: 2024-04-03 date: 2024-04-26 name: National Cancer Institute (NCI) class: NIH briefSummary: Background:
Participants will have follow-up visits 1 month after treatment and then every 2 months for 6 months. Follow-up clinic visits will continue up to 3 years. Follow-ups by phone or email will continue an additional 2 years. conditions: Astrocytoma conditions: Glioma conditions: Recurrent Glioblastoma studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 27 type: ESTIMATED name: Radiation Therapy measure: MTD of daily re-irradiation in participants with recurrent grade 4 gliomas measure: Progression free survival measure: Overall survival measure: Compliance and feasibility of administering PRO in this participant population measure: Tolerability of treatment by assessing adverse events, cognitive function, physical function, and side effect bother measure: Longitudinally describe and evaluate disease and treatment-related symptom severity and interference with daily activities measure: Meaningful change in disease and treatment-related symptoms by using anchors sex: ALL minimumAge: 18 Years maximumAge: 120 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Institutes of Health Clinical Center city: Bethesda state: Maryland zip: 20892 country: United States name: National Cancer Institute Referral Office role: CONTACT phone: 888-624-1937 lat: 38.98067 lon: -77.10026 hasResults: False
nctId: NCT06344117 id: MF3 UHN (IA) briefTitle: Assessment of Volatile Organic Compounds (VOC) for the Diagnosis of Invasive Aspergillosis (IA) in Lung Transplant Recipients acronym: UHN overallStatus: RECRUITING date: 2023-12-12 date: 2025-07 date: 2025-12 date: 2024-04-03 date: 2024-04-03 name: Owlstone Ltd class: INDUSTRY briefSummary: Prospective observational pilot study to evaluate the utility of breath VOCs to detect invasive aspergillosis in lung transplant recipients that are suspected of invasive fungal disease (IFD). conditions: Invasive Aspergillosis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 45 type: ESTIMATED measure: Identifying a statistical relationship between Volatile Organic Compounds detection and the diagnosis of IA by existing International Society for Heart and Lung Transplantation (ISHLT) and MSG/EORTC criteria. measure: Identifying a statistical relationship between the set of VOCs found in exhaled breath and the diagnosis of Aspergillus colonization as defined by ISHLT criteria sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University Health Network status: RECRUITING city: Toronto state: Ontario zip: M5G 2N2 country: Canada name: Shahid Husain, MD,MS role: CONTACT phone: (416) 340-3144 email: shahid.husain@uhn.ca name: Shahid Husain, MD,MS role: PRINCIPAL_INVESTIGATOR lat: 43.70011 lon: -79.4163 hasResults: False
nctId: NCT06344091 id: ZYWB-ZM-AHP-A-003 briefTitle: A Study of Bupivacaine Liposome Injection in Local Analgesia of Pediatric Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-06 date: 2026-09-28 date: 2026-10-12 date: 2024-04-03 date: 2024-04-03 name: Jiangsu HengRui Medicine Co., Ltd. class: INDUSTRY briefSummary: The study is being conducted to evaluate the safety and efficacy of bupivacaine liposome injection for local infiltration analgesia in pediatric orthopedic surgery in the real world. conditions: Local Analgesia Via Infiltration studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: A single-arm study of liposomal bupivacaine injection primaryPurpose: PREVENTION masking: NONE count: 232 type: ESTIMATED name: Bupivacaine Liposome Injection measure: The incidence of Treatment Emergent Adverse events (TEAE) in the cardiac and nervous system measure: The cumulative amount of opioids used in 0-24 hours, 24-48 hours, 48-72 hours and 0-72 hours after administration measure: Time to first rescue analgesia of opioid measure: The proportion of patients who did not use rescue analgesia during 0-24 hours, 24-48 hours, 48-72 hours and 0-72 hours after administration measure: The proportion of patients using patient-controlled intravenous analgesia (PCIA) measure: Pain intensity score at rest after administration for children aged 6 to 7 years measure: Pain intensity score at rest after administration for children aged 8 years and older measure: Pain intensity score on movement (or cough) after administration for children aged 6 to 7 years measure: Pain intensity score on movement (or cough) after administration for children aged 8 years and older measure: Length of Stay sex: ALL minimumAge: 6 Years maximumAge: 17 Years stdAges: CHILD facility: Guangzhou Women and Children's Medical Center city: Guangzhou state: Guangdong zip: 510000 country: China name: Xingrong Song role: CONTACT lat: 23.11667 lon: 113.25 hasResults: False
nctId: NCT06344078 id: SIGMA-d briefTitle: Surgical Italian Guide for the Management of Complicated Acute Diverticulitis Emergency Setting (SIGMA-D). A Prospective Observational Multicenter Study on Behalf of the Italian Society of Colorectal Surgery (SICCR). acronym: SIGMA-D overallStatus: RECRUITING date: 2024-01-01 date: 2025-12-31 date: 2025-12-31 date: 2024-04-03 date: 2024-04-03 name: Societa Italiana di Chirurgia ColoRettale class: NETWORK briefSummary: This study will include data collected from surgical units performing emergency surgery in Italy during 2024, with a one-year follow-up period for each patient. Data for each center will be prospectively collected through a database filled out by the Italian Society of Colorectal Surgery (SICCR) members who participate to the study. Specific data will include: WSES diverticulitis classification, procedure timing, laparoscopic/converted procedures, rate of performed protection ileostomies or colostomies, rate and timing of Hartmann reversal or stoma closure, procedures with more than two operators, procedures with expert first operator, night or weekend procedures, and patients aged over 80. Postoperative data will focus on complication rates and mortality at one, six, and twelve months. conditions: Acute Diverticulitis conditions: Stoma Colostomy conditions: Stoma Ileostomy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 500 type: ESTIMATED name: sigmoid resection and anastomosis / stoma measure: adhesion to guidelines measure: stoma reversal sex: ALL minimumAge: 18 Years maximumAge: 120 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Azienda ospedaliera universitaria paolo giaccone status: RECRUITING city: Palermo country: Italy name: francesco ferrara, medicine and surgery role: CONTACT phone: +393343035829 email: frr.fra@gmail.com name: claudio guerci role: CONTACT phone: +393473898094 email: guerci.clau@gmail.com lat: 38.13205 lon: 13.33561 hasResults: False
nctId: NCT06344065 id: 20220102C briefTitle: Immunogenicity and Safety of Diphtheria, Tetanus, Pertussis (DTaP) Vaccine in 3-month-old Infants overallStatus: RECRUITING date: 2023-12-21 date: 2025-05-25 date: 2028-12-25 date: 2024-04-03 date: 2024-04-03 name: Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd class: INDUSTRY briefSummary: The purpose of this study is to evaluate the safety and immunogenicity of the DTaP in 3-month-old infants. conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 1584 type: ESTIMATED name: Diphtheria, tetanus and acellular pertussis (component) combined vaccine (adsorbed) name: Diphtheria, tetanus and acellular pertussis combined vaccine (adsorbed) name: Diphtheria, tetanus, pertussis (acellular, component), poliomyelitis (inactivated) vaccine (adsorbed) and Haemophilus influenzae type b conjugate vaccine measure: Immunogenicity results of experimental group and active control group (DTaP) measure: Immunogenicity results of experimental group and active control group (DTaP-IPV//PRP-T) measure: Immunogenicity results of experimental group sex: ALL minimumAge: 3 Months maximumAge: 3 Months stdAges: CHILD facility: Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention status: RECRUITING city: Nanning state: Guangxi zip: 530028 country: China name: Yi Mo role: CONTACT phone: +86-13788686968 email: 13647272@qq.com lat: 22.81667 lon: 108.31667 hasResults: False
nctId: NCT06344052 id: SP-002-004 briefTitle: To Assess the Safety and Efficacy of SP-002 With Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma overallStatus: RECRUITING date: 2024-04-09 date: 2026-09-30 date: 2029-03-30 date: 2024-04-03 date: 2024-04-10 name: Stamford Pharmaceuticals, Inc. class: INDUSTRY briefSummary: The goal of this clinical trial is to evaluate the efficacy of using SP-002 in participants with locally advanced Basal cell carcinoma. The main question it aims to answer is what the objective response rate for a basal cell carcinoma tumor is following 1 or 3 cycles of SP-002 treatment given as an add-on to hedgehog pathway inhibitor therapy.
* Arm 3 participants will receive daily hedgehog pathway inhibitor only. conditions: Basal Cell Carcinoma studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 80 type: ESTIMATED name: SP-002 name: Vismodegib measure: Objective response rate measure: Duration of response measure: Progressive free survival measure: Overall survival (OS) measure: Objective Response Rate (ORR) / Complete Response (CR) / Partial Response (PR) measure: Number of subjects discontinuing treatment with SP-002 and/or vismodegib due to toxicity. measure: Number of subjects with delays to SP-002 and/or vismodegib dosing due to toxicity. measure: Incidence and severity of SP-002 and/or vismodegib related AEs. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Research Site status: NOT_YET_RECRUITING city: Phoenix state: Arizona zip: 85006 country: United States lat: 33.44838 lon: -112.07404 facility: Research Site status: NOT_YET_RECRUITING city: Lee's Summit state: Missouri zip: 64064 country: United States lat: 38.91084 lon: -94.38217 facility: Research Site status: RECRUITING city: Cedar Park state: Texas zip: 78613 country: United States lat: 30.5052 lon: -97.82029 facility: Research Site status: NOT_YET_RECRUITING city: Humble state: Texas zip: 77346 country: United States lat: 29.99883 lon: -95.26216 facility: Research Site status: NOT_YET_RECRUITING city: Longview state: Texas zip: 75601 country: United States lat: 32.5007 lon: -94.74049 hasResults: False
nctId: NCT06344039 id: Floating hip briefTitle: Epidemiological Study of Floating Hip Injuries in Assiut University Hospitals overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-05 date: 2024-04-03 date: 2024-04-05 name: Assiut University class: OTHER briefSummary: Aim of the study is to describe and study the patterns of floating hip injuries and assess the current management in Assiut University Hospitals Trauma Centre to help reach the best approach to plan treatment for these severe and difficult injuries. conditions: Hip Fractures conditions: Hip Injuries studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 100 type: ESTIMATED measure: Incidence of floating hip injuries measure: Patterns of injury sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
nctId: NCT06344026 id: ANPD001-02 briefTitle: Phase 1/2a Study of ANPD001 in Parkinson Disease acronym: ASPIRO overallStatus: ENROLLING_BY_INVITATION date: 2024-01-23 date: 2025-10-30 date: 2030-04-30 date: 2024-04-03 date: 2024-04-19 name: Aspen Neuroscience class: INDUSTRY name: California Institute for Regenerative Medicine (CIRM) briefSummary: This clinical trial is designed to test the safety and tolerability of injecting ANPD001 cells that will mature into dopamine-producing cells into the brain of participants with Parkinson Disease. All participants will have ANPD001 cells manufactured from their own previously collected cells. conditions: Parkinson Disease studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Open label, dose escalation of bilateral injection of ANPD001 dopaminergic precursor cells to the putamen primaryPurpose: TREATMENT masking: NONE count: 9 type: ESTIMATED name: ANPD001 name: Custom Device measure: Incidence and severity of treatment emergent adverse events (Safety and Tolerability) measure: "ON" time without troublesome dyskinesia measure: Post-injection change in Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part II (Activities of Daily Living - ADL) and Part III (motor score) in the ON state (total score and scores for Parts I-IV) measure: Post-injection change in the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III score in the practically defined OFF state measure: Post-injection change in the 18F-DOPA uptake in the putamen measure: Incidence and severity of treatment emergent adverse events during long term follow-up (Continued Safety and Tolerability) sex: ALL minimumAge: 50 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Arizona - Banner Health city: Tucson state: Arizona zip: 85724 country: United States lat: 32.22174 lon: -110.92648 facility: Scripps Health city: La Jolla state: California zip: 92037 country: United States lat: 32.84727 lon: -117.2742 facility: University of California, Irvine city: Orange state: California zip: 92868 country: United States lat: 33.78779 lon: -117.85311 facility: University of California, San Francisco city: San Francisco state: California zip: 94143 country: United States lat: 37.77493 lon: -122.41942 facility: Feinstein Institutes city: Manhasset state: New York zip: 11030 country: United States lat: 40.79788 lon: -73.69957 hasResults: False