Actually I think what you mean to say is this Clostridium difficile infection can cause pseudomembraneous colitis which can lead in extreme cases to toxic megacolon The C diff infection often comes about as a result of taking a broadspectrum antibiotic such as Clinamycin which destroys the normal gut flora enabling C diff if present or introduced to completely take over Normally the beneficial species of microorganisms in the gut flora can overcome C diff