The title refers to remarks Hickey had repeatedly made on prior visits to Harrys bar about his wife having a fling with the ice man while he was on the road  This is mentioned several times in the play  I have wondered if any double entendre with the word come was intended which would certainly not be surprising among the characters of this play although nothing of that kind is even hinted at in the dialog and if so that even as just a title it passed without comment in  Then again in  the Cole Porter song My Heart Belongs to Daddy seems to make a subtle reference to cunnilingus  to dine on my fine finnan haddie  asking for more  etc without any adverse results  There is harsh irony in this since it appears that the opposite is the case that Hickeys wife was totally faithful and endlessly forgiving of his womanizing and drinking sprees  This surfeit of virtue creates such selfhatred in Hickey and anger at his wife that he is ultimately driven to kill her to end their common pipe dream that each of his indiscretions will be the last