Question: When did epinephrine stop being available in the country that contains the headquarters of the organization that recognizes the Republic of Cyprus's sovereignty?

full_context: Document 1: Headquarters of the United Nations: The United Nations is headquartered in New York City, in a complex designed by Brazilian architect Oscar Niemeyer and built by the architectural firm Harrison & Abramovitz. The complex has served as the official headquarters of the United Nations since its completion in 1952. It is located in the Turtle Bay neighborhood of Manhattan, on 17 to 18 acres (6.9 to 7.3 ha) of grounds overlooking the East River. Its borders are First Avenue on the west, East 42nd Street to the south, East 48th Street on the north and the East River to the east. The term ``Turtle Bay ''is occasionally used as a metonym for the UN headquarters or for the United Nations as a whole.
Document 2: Cyprus: Cyprus was placed under British administration based on Cyprus Convention in 1878 and formally annexed by Britain in 1914. Even though Turkish Cypriots made up only 18% of the population, the partition of Cyprus and creation of a Turkish state in the north became a policy of Turkish Cypriot leaders and Turkey in the 1950s. Turkish leaders for a period advocated the annexation of Cyprus to Turkey as Cyprus was considered an "extension of Anatolia" by them; while since the 19th century, the majority Greek Cypriot population and its Orthodox church had been pursuing union with Greece, which became a Greek national policy in the 1950s. Following nationalist violence in the 1950s, Cyprus was granted independence in 1960. In 1963, the 11-year intercommunal violence between Greek Cypriots and Turkish Cypriots started, which displaced more than 25,000 Turkish Cypriots and brought the end of Turkish Cypriot representation in the republic. On 15 July 1974, a coup d'état was staged by Greek Cypriot nationalists and elements of the Greek military junta in an attempt at enosis, the incorporation of Cyprus into Greece. This action precipitated the Turkish invasion of Cyprus, which led to the capture of the present-day territory of Northern Cyprus the following month, after a ceasefire collapsed, and the displacement of over 150,000 Greek Cypriots and 50,000 Turkish Cypriots. A separate Turkish Cypriot state in the north was established in 1983. These events and the resulting political situation are matters of a continuing dispute.
Document 3: Headquarters of the United Nations: The United Nations is headquartered in New York City, in a complex designed by Brazilian architect Oscar Niemeyer. The complex has served as the official headquarters of the United Nations since its completion in 1952. It is located in the Turtle Bay neighborhood of Manhattan, on spacious grounds overlooking the East River. Its borders are First Avenue on the west, East 42nd Street to the south, East 48th Street on the north and the East River to the east. The term ``Turtle Bay ''is occasionally used as a metonym for the UN headquarters or for the United Nations as a whole.
Document 4: Cyprus: International pressure led to a ceasefire, and by then 37% of the island had been taken over by the Turks and 180,000 Greek Cypriots had been evicted from their homes in the north. At the same time, around 50,000 Turkish Cypriots moved to the areas under the control of the Turkish Forces and settled in the properties of the displaced Greek Cypriots. Among a variety of sanctions against Turkey, in mid-1975 the US Congress imposed an arms embargo on Turkey for using American-supplied equipment during the Turkish invasion of Cyprus in 1974. There are 1,534 Greek Cypriots and 502 Turkish Cypriots missing as a result of the fighting.
Document 5: Pharmaceutical industry: In 1971, Akira Endo, a Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum, as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory effect as in clinical trials, however a long term study in dogs found toxic effects at higher doses and as a result mevastatin was believed to be too toxic for human use. Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs.
Document 6: United Nations: The UN has six principal organs: the General Assembly (the main deliberative assembly); the Security Council (for deciding certain resolutions for peace and security); the Economic and Social Council (ECOSOC; for promoting international economic and social co-operation and development); the Secretariat (for providing studies, information, and facilities needed by the UN); the International Court of Justice (the primary judicial organ); and the UN Trusteeship Council (inactive since 1994). UN System agencies include the World Bank Group, the World Health Organization, the World Food Programme, UNESCO, and UNICEF. The UN's most prominent officer is the Secretary - General, an office held by Portuguese politician and diplomat António Guterres since 2017. Non-governmental organizations may be granted consultative status with ECOSOC and other agencies to participate in the UN's work.
Document 7: Cyprus: Since 1965, following clashes between the two communities, the Turkish Cypriot seats in the House remain vacant. In 1974 Cyprus was divided de facto when the Turkish army occupied the northern third of the island. The Turkish Cypriots subsequently declared independence in 1983 as the Turkish Republic of Northern Cyprus but were recognised only by Turkey. In 1985 the TRNC adopted a constitution and held its first elections. The United Nations recognises the sovereignty of the Republic of Cyprus over the entire island of Cyprus.
Document 8: Antibiotic: Ernst Chain, Howard Florey and Edward Abraham succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was first proposed by Abraham in 1942 and then later confirmed by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. (see below) The development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Chain and Florey shared the 1945 Nobel Prize in Medicine with Fleming.
Document 9: Cyprus: The Turkish invasion, followed by occupation and the declaration of independence of the TRNC have been condemned by United Nations resolutions, which are reaffirmed by the Security Council every year. The last major effort to settle the Cyprus dispute was the Annan Plan in 2004, drafted by the then Secretary General, Kofi Annan. The plan was put to a referendum in both Northern Cyprus and the Republic of Cyprus. 65% of Turkish Cypriots voted in support of the plan and 74% Greek Cypriots voted against the plan, claiming that it disproportionately favoured the Turkish side. In total, 66.7% of the voters rejected the Annan Plan V. On 1 May 2004 Cyprus joined the European Union, together with nine other countries. Cyprus was accepted into the EU as a whole, although the EU legislation is suspended in the territory occupied by Turkey (TRNC), until a final settlement of the Cyprus problem. In July 2006, the island served as a haven for people fleeing Lebanon, due to the conflict between Israel and Hezbollah (also called "The July War").
Document 10: Pharmaceutical industry: In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of Experimental Therapy in Berlin. The drug was given the commercial name Salvarsan. Ehrlich, noting both the general toxicity of arsenic and the selective absorption of certain dyes by bacteria, hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial infections. Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and found to exhibit partially selective toxicity. Arsphenamine proved to be the first effective treatment for syphilis, a disease which prior to that time was incurable and led inexorably to severe skin ulceration, neurological damage, and death.[citation needed]
Document 11: Cyprus: The events of the summer of 1974 dominate the politics on the island, as well as Greco-Turkish relations. Around 150,000 settlers from Turkey are believed to be living in the north—many of whom were forced from Turkey by the Turkish government—in violation of the Geneva Convention and various UN resolutions. Following the invasion and the capture of its northern territory by Turkish troops, the Republic of Cyprus announced that all of its ports of entry in the north were closed, as they were effectively not under its control.[citation needed]
Document 12: Headquarters of the United Nations: The site of the UN headquarters has extraterritoriality status. This affects some law enforcement where UN rules override the laws of New York City, but it does not give immunity to those who commit crimes there. In addition, the United Nations Headquarters remains under the jurisdiction and laws of the United States, although a few members of the UN staff have diplomatic immunity and so can not be prosecuted by local courts unless the diplomatic immunity is waived by the Secretary - General. In 2005, Secretary - General Kofi Annan waived the immunity of Benon Sevan, Aleksandr Yakovlev, and Vladimir Kuznetsov in relation to the Oil - for - Food Programme, and all were charged in the United States District Court for the Southern District of New York. Benon Sevan later fled the United States to Cyprus, while Aleksandr Yakovlev and Vladimir Kuznetsov decided to stand trial.
Document 13: Pharmaceutical industry: By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion.
Document 14: List of United Nations organizations by location: While the Secretariat of the United Nations is headquartered in New York City, its many bodies, specialized agencies and related organizations are situated in other parts of the world, particularly in Europe.
Document 15: Eli Lilly and Company: The company's most important products introduced prior to World War II included insulin, which Lilly marketed as Iletin (Insulin, Lilly), Amytal, Merthiolate, ephedrine, and liver extracts. Introduced in 1923, Iletin (Insulin, Lilly) was Lilly's first commercial insulin product. In 2002 the company was the leading producer of products for those with diabetes.
ground_truth: 2011
sub_queries: What organization recognizes the sovereignty of the Republic of Cyprus? Answer: The United Nations
the country where the headquarters of The United Nations is located Answer: the United States
When did epinephrine stop being available in the United States ? Answer: 2011