Question: What is one drug that replaced drugs that were first shown to be an anesthetic at the Ether Dome?

full_context: Document 1: House at 17 Cranston Street: The House at 17 Cranston Street in the Jamaica Plain neighborhood of Boston, Massachusetts, is an architecturally eclectic and distinctive 12-sided structure. It was built before 1874 by Archibald Scott on land purchased in 1871. Its main structure consists of three four-sided bays resembling truncated hexagons, which have been joined together in a Y shape around a central hexagon. It is stylistically predominantly Italianate, although there are distinct Gothic Revival elements as well. It occupies a prominent lot overlooking Hyde Square in Jamaica Plain.
Document 2: Diethyl ether: Diethyl ether, or simply ether, is an organic compound in the ether class with the formula 2O . It is a colorless, highly volatile flammable liquid. It is commonly used as a solvent in laboratories and as a starting fluid for some engines. It was formerly used as a general anesthetic, until non-flammable drugs were developed, such as halothane. It has been used as a recreational drug to cause intoxication.
Document 3: Ether Dome: The Ether Dome is a surgical operating amphitheater in the Bulfinch Building at Massachusetts General Hospital in Boston. It served as the hospital's operating room from its opening in 1821 until 1867. It was the site of the first public demonstration of the use of inhaled ether as a surgical anesthetic on October 16, 1846, otherwise known as Ether Day. Crawford Long, a surgeon in Georgia, had previously administered sulfuric ether in 1842, but this went unpublished until 1849. The Ether Dome event occurred when William Thomas Green Morton, a local dentist, used ether to anesthetize Edward Gilbert Abbott. John Collins Warren, the first dean of Harvard Medical School, then painlessly removed part of a tumor from Abbott's neck. After Warren had finished, and Abbott regained consciousness, Warren asked the patient how he felt. Reportedly, Abbott said, "Feels as if my neck's been scratched". Warren then turned to his medical audience and uttered "Gentlemen, this is no Humbug". This was presumably a reference to the unsuccessful demonstration of nitrous oxide anesthesia by Horace Wells in the same theater the previous year, which was ended by cries of "Humbug!" after the patient groaned with pain.
Document 4: Massachusetts General Hospital, Bulfinch Building: The Bulfinch Building of the Massachusetts General Hospital is located on the hospital's main campus on Fruit Street in the West End of Boston, Massachusetts. It was designed by architect Charles Bulfinch, and built between 1818 and 1823, with a major expansion in 1844-46. A National Historic Landmark, it is an excellent example of Classical Revival architecture, and a rare surviving example of an early 19th-century public hospital building. The building is home to the Ether Dome, an operating theater which has been separately designated a National Historic Landmark as the site of the first public demonstration of the use of ether as an anesthetic.
Document 5: Alcohol (drug): Alcohol, also known by its chemical name ethanol, is a psychoactive drug found as the active ingredient in alcoholic beverages such as beer, wine, and distilled spirits. It is one of the oldest and most common recreational drugs, causing the characteristic effects of alcohol intoxication or "drunkenness". Among other effects, alcohol produces euphoria, decreased anxiety, increased sociability, sedation, impairment of cognition, memory, and motor function, and generalized depression of central nervous system function. Ethanol is the only type of alcohol that is found in alcoholic beverages and is commonly used for recreational purposes; other alcohols such as methanol and isopropyl alcohol are toxic and potentially lethal.
Document 6: Ether: Ethers ( ) are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Ethers can again be classified into two varieties: if the alkyl groups are the same on both sides of the oxygen atom, then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. A typical example of the first group is the solvent and anesthetic diethyl ether, commonly referred to simply as "ether" (). Ethers are common in organic chemistry and even more prevalent in biochemistry, as they are common linkages in carbohydrates and lignin.
Document 7: Traffic Tunnel Administration Building: The Traffic Tunnel Administration Building, also known as Boston Police Station Number One, is a historic government building in the North End of Boston, Massachusetts. The building occupies a prominent position facing North End Park off the Rose Kennedy Greenway, and is bounded by the park, North Street, and the trench carrying the exit point of the Sumner Tunnel. The Georgian Revival building was designed by Salem architect John M. Gray and built in 1931. The southern facade, facing the park, was originally used as the administrative facilities for Boston's tunnels, and the eastern facade provided access to the police station. The administration facilities are now used by the local police union, and the police station now houses the police academy.
Document 8: Massachusetts General Hospital: Massachusetts General Hospital (Mass General or MGH) is the original and largest teaching hospital of Harvard Medical School and a biomedical research facility located in the West End neighborhood of Boston, Massachusetts. It is the third oldest general hospital in the United States and the oldest and largest hospital in New England with 950 beds. With Brigham and Women's Hospital, it is one of the two founding members of Partners HealthCare, the largest healthcare provider in Massachusetts. Massachusetts General Hospital conducts the largest hospital-based research program in the world, with an annual research budget of more than $750 million. It is currently ranked as the #3 hospital in the United States by "U.S. News & World Report".
Document 9: Desflurane: Desflurane (1,2,2,2-tetrafluoroethyl difluoromethyl ether) is a highly fluorinated methyl ethyl ether used for maintenance of general anesthesia. Like halothane, enflurane, and isoflurane, it is a racemic mixture of ("R") and ("S") optical isomers (enantiomers). Together with sevoflurane, it is gradually replacing isoflurane for human use, except in economically undeveloped areas, where its high cost precludes its use. It has the most rapid onset and offset of the volatile anesthetic drugs used for general anesthesia due to its low solubility in blood.
Document 10: 2-Ethoxyethanol: 2-Ethoxyethanol, also known by the trademark Cellosolve or ethyl cellosolve, is a solvent used widely in commercial and industrial applications. It is a clear, colorless, nearly odorless liquid that is miscible with water, ethanol, diethyl ether, acetone, and ethyl acetate.
Document 11: Stone Building: The Stone Building, built in 1833, is an historic Greek Revival style building located at 735 Massachusetts Avenue in Lexington, Massachusetts. It was originally a meeting hall for East Lexington, which had its own civic identity and its own church, the neighboring Follen Community Church. Notable speakers at the hall included Ralph Waldo Emerson, Henry David Thoreau, Charles Sumner, Wendell Phillips, Theodore Parker, and Josiah Quincy, Jr. The building was offered to the trustees of the Cary Memorial Library for $2,000 in 1891, by Ellen Stone, granddaughter of Eli Robbins, who built it, and it was named for her. The East Lexington branch library which had been established in 1883, occupied it until the building was closed for repairs in 2007.
Document 12: Ethyl acetate: Ethyl acetate (systematically ethyl ethanoate, commonly abbreviated EtOAc or EA) is the organic compound with the formula CH−COO−CH−CH, simplified to CHO. This colorless liquid has a characteristic sweet smell (similar to pear drops) and is used in glues, nail polish removers, decaffeinating tea and coffee, and cigarettes (see list of additives in cigarettes). Ethyl acetate is the ester of ethanol and acetic acid; it is manufactured on a large scale for use as a solvent. The combined annual production in 1985 of Japan, North America, and Europe was about 400,000 tonnes. In 2004, an estimated 1.3 million tonnes were produced worldwide.
Document 13: Anisole: Anisole, or methoxybenzene, is an organic compound with the formula CHOCH. It is a colorless liquid with a smell reminiscent of anise seed, and in fact many of its derivatives are found in natural and artificial fragrances. The compound is mainly made synthetically and is a precursor to other synthetic compounds. It is an ether.
Document 14: Edward Gilbert Abbott: Edward Gilbert Abbott (1825–1855) was the patient upon whom William T. G. Morton first publicly demonstrated the use of ether as a surgical anesthetic. The operation was done in an amphitheater at the Massachusetts General Hospital now known as the Ether Dome on 16 October 1846. After Morton administered the ether, surgeon John Collins Warren removed a portion of a tumor from Abbott's neck. After Warren had finished, and Abbott regained consciousness, Warren asked the patient how he felt. Reportedly, Abbott said, "Feels as if my neck's been scratched." Warren then turned to his medical audience and uttered "Gentlemen, this is no Humbug." This was presumably a reference to the unsuccessful demonstration of nitrous oxide anesthesia by Horace Wells in the same theater the previous year, which was ended by cries of "Humbug!" after the patient groaned with pain.
Document 15: Ethanol: Ethanol, also called alcohol, ethyl alcohol, and drinking alcohol, is a compound and simple alcohol with the chemical formula C2H5OH . Its formula can be written also as CH3 −CH2 −OH or C2H5 −OH (an ethyl group linked to a hydroxyl group), and is often abbreviated as EtOH. Ethanol is a volatile, flammable, colorless liquid with a slight characteristic odor. It is used as a drug and is the principal type of alcohol found in alcoholic drinks.
ground_truth: halothane