Question: Sale of inhaled epinephrine ceased in the country responsible for GPS when?

full_context: Document 1: Geodetic datum: The Global Positioning System (GPS) uses the World Geodetic System 1984 (WGS 84) to determine the location of a point near the surface of the Earth.
Document 2: Pharmaceutical industry: A Federal Trade Commission report issued in 1958 attempted to quantify the effect of antibiotic development on American public health. The report found that over the period 1946-1955, there was a 42% drop in the incidence of diseases for which antibiotics were effective and only a 20% drop in those for which antibiotics were not effective. The report concluded that "it appears that the use of antibiotics, early diagnosis, and other factors have limited the epidemic spread and thus the number of these diseases which have occurred". The study further examined mortality rates for eight common diseases for which antibiotics offered effective therapy (syphilis, tuberculosis, dysentery, scarlet fever, whooping cough, meningococcal infections, and pneumonia), and found a 56% decline over the same period. Notable among these was a 75% decline in deaths due to tuberculosis.
Document 3: Pharmaceutical industry: Some of these estimates also take into account the opportunity cost of investing capital many years before revenues are realized (see Time-value of money). Because of the very long time needed for discovery, development, and approval of pharmaceuticals, these costs can accumulate to nearly half the total expense. A direct consequence within the pharmaceutical industry value chain is that major pharmaceutical multinationals tend to increasingly outsource risks related to fundamental research, which somewhat reshapes the industry ecosystem with biotechnology companies playing an increasingly important role, and overall strategies being redefined accordingly. Some approved drugs, such as those based on re-formulation of an existing active ingredient (also referred to as Line-extensions) are much less expensive to develop.
Document 4: USA-192: USA-192, also known as GPS IIR-16(M), GPS IIRM-3 and GPS SVN-58, is an American navigation satellite which forms part of the Global Positioning System. It was the third of eight Block IIRM satellites to be launched, and the sixteenth of twenty one Block IIR satellites overall. It was built by Lockheed Martin, using the AS-4000 satellite bus.
Document 5: Pharmaceutical industry: By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion.
Document 6: Global Positioning System: The GPS project was launched by the U.S. Department of Defense in 1973 for use by the United States military and became fully operational in 1995. It was allowed for civilian use in the 1980s. Advances in technology and new demands on the existing system have now led to efforts to modernize the GPS and implement the next generation of GPS Block IIIA satellites and Next Generation Operational Control System (OCX). Announcements from Vice President Al Gore and the White House in 1998 initiated these changes. In 2000, the U.S. Congress authorized the modernization effort, GPS III. During the 1990s, GPS quality was degraded by the United States government in a program called ``Selective Availability '', however, this is no longer the case, and was discontinued in May 2000 by law signed by President Bill Clinton. New GPS receiver devices using the L5 frequency to begin release in 2018 are expected to have a much higher accuracy and pinpoint a device to within 30 centimeters or just under one foot.
Document 7: USA-166: USA-166, also known as GPS IIR-8 and GPS SVN-56, is an American navigation satellite which forms part of the Global Positioning System. It was the eighth Block IIR GPS satellite to be launched, out of thirteen in the original configuration, and twenty one overall. It was built by Lockheed Martin, using the AS-4000 satellite bus.
Document 8: Eli Lilly and Company: The company's most important products introduced prior to World War II included insulin, which Lilly marketed as Iletin (Insulin, Lilly), Amytal, Merthiolate, ephedrine, and liver extracts. Introduced in 1923, Iletin (Insulin, Lilly) was Lilly's first commercial insulin product. In 2002 the company was the leading producer of products for those with diabetes.
Document 9: BeiDou: The ranging signals are based on the CDMA principle and have complex structure typical of Galileo or modernized GPS. Similar to the other GNSS, there will be two levels of positioning service: open and restricted (military). The public service shall be available globally to general users. When all the currently planned GNSS systems are deployed, the users will benefit from the use of a total constellation of 75+ satellites, which will significantly improve all the aspects of positioning, especially availability of the signals in so-called urban canyons. The general designer of the COMPASS navigation system is Sun Jiadong, who is also the general designer of its predecessor, the original BeiDou navigation system.
Document 10: Global Positioning System: The Global Positioning System (GPS), originally Navstar GPS, is a space - based radionavigation system owned by the United States government and operated by the United States Air Force. It is a global navigation satellite system that provides geolocation and time information to a GPS receiver anywhere on or near the Earth where there is an unobstructed line of sight to four or more GPS satellites.
Document 11: BeiDou: Unlike the American GPS, Russian GLONASS, and European Galileo systems, which use medium Earth orbit satellites, BeiDou-1 uses satellites in geostationary orbit. This means that the system does not require a large constellation of satellites, but it also limits the coverage to areas on Earth where the satellites are visible. The area that can be serviced is from longitude 70°E to 140°E and from latitude 5°N to 55°N. A frequency of the system is 2491.75 MHz.
Document 12: Annelid: Accounts of the use of leeches for the medically dubious practise of blood-letting have come from China around 30 AD, India around 200 AD, ancient Rome around 50 AD and later throughout Europe. In the 19th century medical demand for leeches was so high that some areas' stocks were exhausted and other regions imposed restrictions or bans on exports, and Hirudo medicinalis is treated as an endangered species by both IUCN and CITES. More recently leeches have been used to assist in microsurgery, and their saliva has provided anti-inflammatory compounds and several important anticoagulants, one of which also prevents tumors from spreading.
Document 13: Pharmaceutical industry: In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of Experimental Therapy in Berlin. The drug was given the commercial name Salvarsan. Ehrlich, noting both the general toxicity of arsenic and the selective absorption of certain dyes by bacteria, hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial infections. Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and found to exhibit partially selective toxicity. Arsphenamine proved to be the first effective treatment for syphilis, a disease which prior to that time was incurable and led inexorably to severe skin ulceration, neurological damage, and death.[citation needed]
Document 14: Pharmaceutical industry: In 1971, Akira Endo, a Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum, as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory effect as in clinical trials, however a long term study in dogs found toxic effects at higher doses and as a result mevastatin was believed to be too toxic for human use. Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs.
Document 15: Antibiotic: Ernst Chain, Howard Florey and Edward Abraham succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was first proposed by Abraham in 1942 and then later confirmed by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. (see below) The development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Chain and Florey shared the 1945 Nobel Prize in Medicine with Fleming.
ground_truth: 2011
sub_queries: where did the global positioning system (gps) originate Answer: the United States
When did epinephrine stop being available in the United States ? Answer: 2011