Question: When did epinephrine stop being available in the country where the organization IPCC is part of is headquartered?

full_context: Document 1: Headquarters of the United Nations: The United Nations is headquartered in New York City, in a complex designed by Brazilian architect Oscar Niemeyer and built by the architectural firm Harrison & Abramovitz. The complex has served as the official headquarters of the United Nations since its completion in 1952. It is located in the Turtle Bay neighborhood of Manhattan, on 17 to 18 acres (6.9 to 7.3 ha) of grounds overlooking the East River. Its borders are First Avenue on the west, East 42nd Street to the south, East 48th Street on the north and the East River to the east. The term ``Turtle Bay ''is occasionally used as a metonym for the UN headquarters or for the United Nations as a whole.
Document 2: Intergovernmental Panel on Climate Change: In February 2010, in response to controversies regarding claims in the Fourth Assessment Report, five climate scientists – all contributing or lead IPCC report authors – wrote in the journal Nature calling for changes to the IPCC. They suggested a range of new organizational options, from tightening the selection of lead authors and contributors, to dumping it in favor of a small permanent body, or even turning the whole climate science assessment process into a moderated "living" Wikipedia-IPCC. Other recommendations included that the panel employ a full-time staff and remove government oversight from its processes to avoid political interference.
Document 3: Eli Lilly and Company: The company's most important products introduced prior to World War II included insulin, which Lilly marketed as Iletin (Insulin, Lilly), Amytal, Merthiolate, ephedrine, and liver extracts. Introduced in 1923, Iletin (Insulin, Lilly) was Lilly's first commercial insulin product. In 2002 the company was the leading producer of products for those with diabetes.
Document 4: Headquarters of the United Nations: The site of the UN headquarters has extraterritoriality status. This affects some law enforcement where UN rules override the laws of New York City, but it does not give immunity to those who commit crimes there. In addition, the United Nations Headquarters remains under the jurisdiction and laws of the United States, although a few members of the UN staff have diplomatic immunity and so can not be prosecuted by local courts unless the diplomatic immunity is waived by the Secretary - General. In 2005, Secretary - General Kofi Annan waived the immunity of Benon Sevan, Aleksandr Yakovlev, and Vladimir Kuznetsov in relation to the Oil - for - Food Programme, and all were charged in the United States District Court for the Southern District of New York. Benon Sevan later fled the United States to Cyprus, while Aleksandr Yakovlev and Vladimir Kuznetsov decided to stand trial.
Document 5: United Nations Environment Programme: The United Nations Environment Programme (UNEP), a programme of the United Nations, coordinates the organization's environmental activities and assists developing countries in implementing environmentally sound policies and practices. It was founded by Maurice Strong, its first director, as a result of the United Nations Conference on the Human Environment (Stockholm Conference) in June 1972 and has overall responsibility for environmental problems among United Nations agencies; however, international talks on specialized issues, such as addressing climate change or combating desertification, are overseen by other UN organizations, like the Bonn-based Secretariat of the United Nations Framework Convention on Climate Change and the United Nations Convention to Combat Desertification. UNEP's activities cover a wide range of issues regarding the atmosphere, marine and terrestrial ecosystems, environmental governance and green economy. It has played a significant role in developing international environmental conventions, promoting environmental science and information and illustrating the way those can be implemented in conjunction with policy, working on the development and implementation of policy with national governments, regional institutions in conjunction with environmental non-governmental organizations (NGOs). UNEP has also been active in funding and implementing environment related development projects.
Document 6: Intergovernmental Panel on Climate Change: The Intergovernmental Panel on Climate Change (IPCC) is a scientific intergovernmental body under the auspices of the United Nations, set up at the request of member governments. It was first established in 1988 by two United Nations organizations, the World Meteorological Organization (WMO) and the United Nations Environment Programme (UNEP), and later endorsed by the United Nations General Assembly through Resolution 43/53. Membership of the IPCC is open to all members of the WMO and UNEP. The IPCC produces reports that support the United Nations Framework Convention on Climate Change (UNFCCC), which is the main international treaty on climate change. The ultimate objective of the UNFCCC is to "stabilize greenhouse gas concentrations in the atmosphere at a level that would prevent dangerous anthropogenic [i.e., human-induced] interference with the climate system". IPCC reports cover "the scientific, technical and socio-economic information relevant to understanding the scientific basis of risk of human-induced climate change, its potential impacts and options for adaptation and mitigation."
Document 7: Antibiotic: Ernst Chain, Howard Florey and Edward Abraham succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was first proposed by Abraham in 1942 and then later confirmed by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. (see below) The development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Chain and Florey shared the 1945 Nobel Prize in Medicine with Fleming.
Document 8: Intergovernmental Panel on Climate Change: In addition to climate assessment reports, the IPCC is publishing Special Reports on specific topics. The preparation and approval process for all IPCC Special Reports follows the same procedures as for IPCC Assessment Reports. In the year 2011 two IPCC Special Report were finalized, the Special Report on Renewable Energy Sources and Climate Change Mitigation (SRREN) and the Special Report on Managing Risks of Extreme Events and Disasters to Advance Climate Change Adaptation (SREX). Both Special Reports were requested by governments.
Document 9: List of United Nations organizations by location: While the Secretariat of the United Nations is headquartered in New York City, its many bodies, specialized agencies and related organizations are situated in other parts of the world, particularly in Europe.
Document 10: Pharmaceutical industry: By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion.
Document 11: United Nations: The UN has six principal organs: the General Assembly (the main deliberative assembly); the Security Council (for deciding certain resolutions for peace and security); the Economic and Social Council (ECOSOC; for promoting international economic and social co-operation and development); the Secretariat (for providing studies, information, and facilities needed by the UN); the International Court of Justice (the primary judicial organ); and the UN Trusteeship Council (inactive since 1994). UN System agencies include the World Bank Group, the World Health Organization, the World Food Programme, UNESCO, and UNICEF. The UN's most prominent officer is the Secretary - General, an office held by Portuguese politician and diplomat António Guterres since 2017. Non-governmental organizations may be granted consultative status with ECOSOC and other agencies to participate in the UN's work.
Document 12: Pharmaceutical industry: In 1971, Akira Endo, a Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum, as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory effect as in clinical trials, however a long term study in dogs found toxic effects at higher doses and as a result mevastatin was believed to be too toxic for human use. Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs.
Document 13: Intergovernmental Panel on Climate Change: The IPCC receives funding through the IPCC Trust Fund, established in 1989 by the United Nations Environment Programme (UNEP) and the World Meteorological Organization (WMO), Costs of the Secretary and of housing the secretariat are provided by the WMO, while UNEP meets the cost of the Depute Secretary. Annual cash contributions to the Trust Fund are made by the WMO, by UNEP, and by IPCC Members; the scale of payments is determined by the IPCC Panel, which is also responsible for considering and adopting by consensus the annual budget. The organisation is required to comply with the Financial Regulations and Rules of the WMO.
Document 14: Headquarters of the United Nations: The United Nations is headquartered in New York City, in a complex designed by Brazilian architect Oscar Niemeyer. The complex has served as the official headquarters of the United Nations since its completion in 1952. It is located in the Turtle Bay neighborhood of Manhattan, on spacious grounds overlooking the East River. Its borders are First Avenue on the west, East 42nd Street to the south, East 48th Street on the north and the East River to the east. The term ``Turtle Bay ''is occasionally used as a metonym for the UN headquarters or for the United Nations as a whole.
Document 15: Pharmaceutical industry: In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of Experimental Therapy in Berlin. The drug was given the commercial name Salvarsan. Ehrlich, noting both the general toxicity of arsenic and the selective absorption of certain dyes by bacteria, hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial infections. Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and found to exhibit partially selective toxicity. Arsphenamine proved to be the first effective treatment for syphilis, a disease which prior to that time was incurable and led inexorably to severe skin ulceration, neurological damage, and death.[citation needed]
ground_truth: 2011
sub_queries: What organization is the IPCC a part of? Answer: the United Nations
the country where the headquarters of the United Nations is located Answer: the United States
When did epinephrine stop being available in the United States ? Answer: 2011