Question: Crystal arthropathy is a class of joint disorder (called "arthropathy"), which acid is characterized by accumulation of tiny crystals in one or more joints. Polarizing microscopy and application of other crystallographic techniques have improved identification of different microcrystals including monosodium urate, what is the heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula CHNO?

full_context: Document 1: Gluconic acid: Gluconic acid is an organic compound with molecular formula CHO and condensed structural formula HOCH(CHOH)COOH. It is one of the 16 stereoisomers of 2,3,4,5,6-pentahydroxyhexanoic acid.
Document 2: Radiohalo: Radiohalos or pleochroic halos are microscopic, spherical shells of discolouration within minerals such as biotite that occur in granite and other igneous rocks. The shells are zones of radiation damage caused by the inclusion of minute radioactive crystals within the host crystal structure. The inclusions are typically zircon, apatite, or titanite which can accommodate uranium or thorium within their crystal structures . One explanation is that the discolouration is caused by alpha particles emitted by the nuclei; the radius of the concentric shells are proportional to the particle's energy . The phenomenon of radiohalos has been known to geologists since the early part of the 20th century, but wider interest has been prompted by the claims of creationist Robert V. Gentry that radiohalos in biotite are evidence for a young earth .
Document 3: Allantoin: Allantoin is a chemical compound with formula CHNO. It is also called 5-ureidohydantoin or glyoxyldiureide. It is a diureide of glyoxylic acid. Allantoin is a major metabolic intermediate in most organisms including animals, plants and bacteria. It is produced from uric acid, which is a degradation product of purine nucleobases, by urate oxidase (or uricase).
Document 4: Jaccoud arthropathy: Jaccoud arthropathy (JA), Jaccoud deformity or Jaccoud's arthopathy is a chronic non-erosive reversible joint disorder that may occur after repeated bouts of arthritis. It is caused by inflammation of the joint capsule and subsequent fibrotic retraction, causing ulnar deviation of the fingers, through metacarpophalangeal joint (MCP) subluxation, primarily of the ring and little-finger. Joints in the feet, knees and shoulders may also get affected. It is commonly associated with systemic lupus erythematosus (SLE), and occurs in roughly 5% of all cases.
Document 5: Quasicrystal: A quasiperiodic crystal, or quasicrystal, is a structure that is ordered but not periodic. A quasicrystalline pattern can continuously fill all available space, but it lacks translational symmetry. While crystals, according to the classical crystallographic restriction theorem, can possess only two, three, four, and six-fold rotational symmetries, the Bragg diffraction pattern of quasicrystals shows sharp peaks with other symmetry orders, for instance five-fold.
Document 6: Azetidine-2-carboxylic acid: Azetidine-2-carboxylic acid (abbreviated Aze) is a plant non-protein amino acid homologue of proline with the molecular formula CHNO. Aze is a heterocyclic, 4 membered ring with nitrogen as its heteroatom (an azetidine), and a carboxylic acid group substituted on one of the ring carbon atoms. The main difference between Aze and proline is the ring of Aze has four members and the ring of proline has five. Aze has the ability to act as an analog of proline and can be incorporated into proteins in place of proline.
Document 7: Craniomandibular osteopathy: Craniomandibular osteopathy, also known as lion's jaw, is a developmental disease in dogs causing extensive bony changes in the mandible and skull. In this disease, a cyclical resorption of normal bone and replacement by immature bone occurs along the inner and outer surfaces of the affected bones. It usually occurs between the ages of 3 and 8 months. Breeds most commonly affected include the West Highland White Terrier, Scottish Terrier, Cairn Terrier, and Boston Terrier. It is rare in large-breed dogs, but it has been reported. Symptoms include firm swelling of the jaw, drooling, pain, and difficulty eating.
Document 8: Uric acid: Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula CHNO. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. High blood concentrations of uric acid can lead to gout and are associated with other medical conditions including diabetes and the formation of ammonium acid urate kidney stones.
Document 9: Crystallographic restriction theorem: The crystallographic restriction theorem in its basic form was based on the observation that the rotational symmetries of a crystal are usually limited to 2-fold, 3-fold, 4-fold, and 6-fold. However, quasicrystals can occur with other diffraction pattern symmetries, such as 5-fold; these were not discovered until 1982 by Dan Shechtman.
Document 10: Acute uric acid nephropathy: Acute uric acid nephropathy (AUAN, also acute urate nephropathy) is a rapidly worsening (decreasing) kidney function (renal insufficiency) that is caused by high levels of uric acid in the urine (hyperuricosuria).
Document 11: Biomineralization: Biomineralization is the process by which living organisms produce minerals, often to harden or stiffen existing tissues. Such tissues are called mineralized tissues. It is an extremely widespread phenomenon; all six taxonomic kingdoms contain members that are able to form minerals, and over 60 different minerals have been identified in organisms. Examples include silicates in algae and diatoms, carbonates in invertebrates, and calcium phosphates and carbonates in vertebrates. These minerals often form structural features such as sea shells and the bone in mammals and birds. Organisms have been producing mineralised skeletons for the past 550 million years. Other examples include copper, iron and gold deposits involving bacteria. Biologically-formed minerals often have special uses such as magnetic sensors in magnetotactic bacteria (FeO), gravity sensing devices (CaCO, CaSO, BaSO) and iron storage and mobilization (FeO•HO in the protein ferritin).
Document 12: Crystal arthropathy: Crystal arthropathy is a class of joint disorder (called "arthropathy") that is characterized by accumulation of tiny crystals in one or more joints. Polarizing microscopy and application of other crystallographic techniques have improved identification of different microcrystals including monosodium urate, calcium pyrophosphate dihydrate, calcium hydroxyapatite, and calcium oxalate.
Document 13: Hyperuricemia: Hyperuricemia is an abnormally high level of uric acid in the blood. In the pH conditions of body fluid, uric acid exists largely as urate, the ion form. The amount of urate in the body depends on the balance between the amount of purines eaten in food, the amount of urate synthesised within the body (e.g., through cell turnover), and the amount of urate that is excreted in urine or through the gastrointestinal tract. In humans, the upper end of the normal range is 360 µmol/L (6 mg/dL) for women and 400 µmol/L (6.8 mg/dL) for men.
Document 14: Tophus: A tophus (Latin: "stone", plural tophi) is a deposit of uric acid crystals, in the form of monosodium urate crystals, in people with longstanding hyperuricemia (high levels of uric acid in the blood). Tophi are pathognomonic for the disease gout. Most people with tophi have had previous attacks of acute arthritis, eventually leading to the formation of tophi. Chronic tophaceous gout is known as Harrison Syndrome.
Document 15: Uricosuric: Uricosuric medications (drugs) are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma. In general, this effect is achieved by action on the proximal tubule of the kidney. Drugs that reduce blood uric acid are not all uricosurics; blood uric acid can be reduced by other mechanisms (see other ).
ground_truth: Uric acid