Question: What is the active ingredient in the product Freederm that treats acne?

full_context: Document 1: Safinamide: Safinamide (INN; brand name Xadago) is a drug used as an add-on treatment for Parkinson's disease during "off" episodes; it has multiple modes of action, including the inhibition of monoamine oxidase B.
Document 2: Robert L. Last: Robert L. Last is a plant biochemical genomicist who studies metabolic processes that protect plants from the environment and produce products important for animal and human nutrition. His research has covered (1) production and breakdown of essential amino acids, (2) the synthesis and protective roles of Vitamin C (ascorbic acid) and Vitamin E (tocopherols) as well as identification of mechanisms that protect photosystem II from damage, and (3) synthesis and biological functions of plant protective specialized metabolites (plant secondary metabolites). Four central questions are: (i) how are leaf and seed amino acids levels regulated, (ii.) what mechanisms protect and repair photosystem II from stress-induced damage, (iii.) how do plants produce protective metabolites in their glandular secreting trichomes (iv.) and what are the evolutionary mechanisms that contribute to the tremendous diversity of specialized metabolites that protect plants from insects and pathogens and are used as therapeutic agents.
Document 3: Pregnenolone acetate: Pregnenolone acetate (brand names Antofin, Previsone, Pregno-Pan), also known as pregn-5-en-3β-ol-20-one 3β-acetate, is a synthetic pregnane steroid and an ester of pregnenolone which is described as a glucocorticoid and as a skin-conditioning and skin anti-aging agent. It has been found to significantly reduce wrinkles in elderly women when applied in the form of a 0.5% topical cream, effects which were suggested to be due to improved hydration of the skin. Pregnenolone acetate has been marketed in France in a topical cream containing 1% pregnenolone acetate and 10% "sex hormone" for the treatment of premature skin aging but was withdrawn from the market in 1992. Although the drug has been described by some sources as a glucocorticoid, other authors have stated that systemic pregnenolone acetate has no undesirable metabolic or toxic effects even at high dosages.
Document 4: Niacin (band): Niacin is a neo-fusion instrumental trio featuring bassist Billy Sheehan, drummer Dennis Chambers, and keyboardist John Novello. Founded in 1996, the band's name comes from the timbral foundation of the Hammond B3 organ; vitamin B is also known as niacin.
Document 5: Nicotinamide: Nicotinamide (NAA), also known as niacinamide, is a vitamin found in food, used as a dietary supplement, and used as a medication. As a supplement, it is used by mouth to prevent and treat pellagra (niacin deficiency). While nicotinic acid (niacin) may be used for this purpose, nicotinamide has the benefit of not causing skin flushing. As a cream, it is used to treat acne.
Document 6: Nivea: Nivea (] ) is a German personal care brand that specializes in skin- and body-care. It is owned by the Hamburg-based company Beiersdorf Global AG. The company was founded on March 28, 1882, by pharmacist Paul Carl Beiersdorf. In 1890, it was sold to Oscar Troplowitz. Troplowitz kept working with his scientific consultant Paul Gerson Unna and the German chemist Isaac Lifschütz on a new skin care cream. In 1900, Lifschütz developed a water-in-oil emulsion as a skin cream with Eucerit, the first stable emulsion of its kind. This was the basis for Eucerin and, later, Nivea. "Nivea" comes from the Latin word "niveus/nivea/niveum", meaning "snow-white".
Document 7: Avita Medical: Avita Medical is a clinical and commercial company developing and marketing a range of respiratory and regenerative products. The first regenerative medicine product brought to the market by Avita Medical was ReCell spray-on skin for the treatment of burns. The two latest products are ReNovaCell, for Aesthetics and Plastic applications including skin trauma, and ReGenerCell for the treatment of chronic wounds. The Avita Medical regenerative product range is currently marketed in EMEA countries and Australia.
Document 8: Stridex: Stridex (originally spelled Stri-Dex) is an American acne treatment and prevention medicine, originally registered trademark of Bayer Corporation. It comes in the form of fibrous pads saturated with astringents and contained in a plastic tub of fifty-five to ninety pads. Most products in the Stridex line contain as the active ingredient salicylic acid (0.5–2.5%); Stridex "Power Pads", however, contain instead benzoyl peroxide (2.5%), which is considered by medical professionals to be "the most effective and widely used nonprescription medication for both types of acne". However, they also warn about possible side effects: dryness of the skin, possible burning, and tingling. Patients are advised to apply treatment with caution around lips, nose and mouth, or cuts and scrapes, and also avoid excessive sun exposure. In 2013, FDA started to investigate a possible link between benzoyl peroxide- and/or salicylic acid-based acne prevention medicine with hypersensitivity and anaphylactic reactions without calling off any products or placing warnings.
Document 9: Ascorbic acid (molecular aspects): Ascorbic acid is a naturally occurring organic compound with antioxidant properties. It is a white solid, but impure samples can appear yellowish. It dissolves well in water to give mildly acidic solutions. Ascorbic acid is one form ("vitamer") of vitamin C. It was originally called -hexuronic acid, but, when it was found to have vitamin C activity in animals ("vitamin C" being defined as a vitamin activity, not then a specific substance), the suggestion was made to rename it. The new name, ascorbic acid, is derived from "a-" (meaning "no") and "scorbutus" (scurvy), the disease caused by a deficiency of vitamin C. Because it is derived from glucose, many animals are able to produce it, but humans require it as part of their nutrition. Other vertebrates which lack the ability to produce ascorbic acid include some primates, guinea pigs, teleost fishes, bats, and some birds, all of which require it as a dietary micronutrient (that is, in vitamin form).
Document 10: Freederm: Freederm is a UK brand of acne and skin care medication manufactured by Diomed Developments Limited. The products include Nicotinamide as an active ingredient, which is claimed by the company to be "clinically proven to help get rid of inflamed red spots".
Document 11: Gold Bond: Gold Bond is a brand of over-the-counter skin care products produced by Chattem of Chattanooga, Tennessee, now a subsidiary of the French pharmaceutical company Sanofi. It is available as both a powder and a topical cream. Gold Bond is used to curb moisture, control odor, and soothe minor skin irritations, notably jock itch. Spin-off products are designed for specific uses, such as foot powders or powders for infants to treat diaper rash.
Document 12: No. 7 (brand): No7 is a brand of anti-ageing creams, skincare and cosmetic products developed by Boots UK, so called because the number seven was, at the time, frequently used to denote perfection and Boots wanted it to stand out from the rest of the own-brand merchandise it produced. The TV campaign for the products uses the Jessie J song Sexy Lady as its theme tune.
Document 13: Palmitoyl pentapeptide-4: Palmitoyl pentapeptide-4 (palmitoyl pentapeptide-3 before 2006) is a matrikine used in anti-wrinkle cosmetics. It was launched in 2000 as an active ingredient for the personal care industry under the trade name Matrixyl by the French cosmetic active ingredient manufacturer Sederma SAS.
Document 14: Vitamin: A vitamin is an organic compound and an essential nutrient that an organism requires in limited amounts. An organic chemical compound (or related set of compounds) is called a vitamin when the organism cannot synthesize the compound in sufficient quantities, and it must be obtained through the diet; thus, the term "vitamin" is conditional upon the circumstances and the particular organism. For example, ascorbic acid (one form of vitamin C) is a vitamin for humans, but not for most other animals. Vitamin D is essential only for people who do not have adequate skin exposure to sunlight, as ultraviolet light promotes synthesis in skin cells. Supplementation is important for the treatment of certain health problems, but there is little evidence of nutritional benefit when used by otherwise healthy people.
Document 15: Galderma: Galderma S.A. is a pharmaceutical subsidiary specializing in the research, development and marketing of dermatological treatments and became a wholly owned subsidiary of Nestlé in 2014.
ground_truth: Nicotinamide