El medicamento ARANESP 100 microgramos SOLUCION INYECTABLE EN JERINGA PRECARGADA con los principios activos DARBEPOETINA ALFA tiene la siguiente información en la sección 4.8
Resumen del perfil de seguridad

Las reacciones adversas asociadas a Aranesp que han sido identificadas son hipertensión, ictus, eventos tromboembólicos, convulsiones, reacciones alérgicas, erupción / eritema y aplasia pura de células rojas (APCR); ver sección 4.4.

En los estudios en que se administraba Aranesp por vía subcutánea, se notificó dolor en el lugar de la inyección atribuible al tratamiento. Dichas molestias fueron, en general de naturaleza leve y transitoria, y ocurrieron predominantemente después de la primera inyección.

Tabla de reacciones adversas

A continuación, se lista la incidencia de reacciones adversas por órgano y frecuencia: las frecuencias se definen como: muy frecuentes (≥ 1/10), frecuentes (≥ 1/100 a < 1/10), poco frecuentes (≥ 1/1.000 a < 1/100), raras (≥ 1/10.000 a < 1/1.000); muy raras (< 1/10.000), frecuencia no conocida (no puede estimarse a partir de los datos disponibles).

Los datos se presentan por separado para pacientes con IRC y para pacientes con cáncer, reflejando los diferentes perfiles de reacciones adversas en esas poblaciones.

*Pacientes con insuficiencia renal crónica*

Los datos de ensayos controlados presentados incluyen 1.357 pacientes de los cuales 766 fueron tratados con Aranesp y 591 con r-HuEPO. En el grupo tratado con Aranesp, el 83% de los pacientes estaban en diálisis y el 17% no. El ictus se identificó como una reacción adversa en un ensayo clínico adicional (TREAT, ver sección 5.1).

La incidencia de reacciones adversas en los ensayos clínicos controlados y en la experiencia postcomercialización es:

![](data:image/jpg;base64,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)

\* ver sección “Descripción de las reacciones adversas seleccionadas”

\* ver sección 4.4

*Pacientes con cáncer*

Las reacciones adversas se determinaron a partir de los datos combinados obtenidos de siete ensayos de Aranesp aleatorizados, doble ciego, controlados con placebo y que incluyeron un total de 2.112 pacientes (1.200 en el brazo de Aranesp y 912 en el brazo de placebo). En los ensayos clíncos se incluyeron pacientes con tumores sólidos (ej.: pulmón, mama, colon, ovario) y con tumores linfoides (ej.: linfoma, mieloma múltiple).

La incidencia de reacciones adversas en los ensayos clínicos controlados y en la experiencia postcomercialización es:

 **Clasificación por órganos y sistemas de MedDRA**  **Incidencia**  **Reacción adversa** 
      
 Trastornos del sistema inmunológico  Muy frecuentes\*  Hipersensibilidad 
 Trastornos del sistema nervioso  Poco frecuentes\*  Convulsiones 
 Trastornos cardíacos  Frecuentes\*  Hipertensión 
 Trastornos vasculares  Frecuentes  Eventos tromboembólicos, incluyendo embolia pulmonar 
 Trastornos del sistema inmunológico  Muy frecuentes\*  Hipersensibilidad 
 Trastornos de la piel y del tejido subcutáneo  Frecuentes  Erupción/eritema 
 No conocida\*  SSJ/NET, eritema multiforme, aparición de ampollas, exfoliación de la piel 
 Trastornos generales y alteraciones en el lugar de administración  Muy frecuentes  Edema 
 Frecuentes  Dolor en el lugar de la inyección 
 No conocida  Hematoma en el lugar de la inyección Hemorragía en el lugar de la inyección 

\*ver sección “Descripción de las reacciones adversas seleccionadas”

\* ver sección 4.4

Descripción de las reacciones adversas seleccionadas

*Pacientes con insuficiencia renal crónica*

En el estudio TREAT, el ictus se notificó como frecuente en los pacientes con IRC (ver seccion 5.1).

En casos aislados, se han notificado, anticuerpos neutralizantes antieritropoyetina por medio de aplasia pura de células rojas (APCR) asociado con el tratamiento de Aranesp, predominantemente en pacientes con IRC tratados por vía subcutánea. En caso de que la APCR sea diagnosticada, se debe interrumpir el tratamiento con Aranesp y no se debe cambiar a los pacientes a otra proteína eritropoyética recombinante (ver sección 4.4).

La frecuencia de todas las reacciones de hipersensibilidad estimada de los datos del ensayo clínico fue muy frecuente en pacientes con IRC. Se han notificado reacciones de hipersensibilidad graves, incluyendo reacciones anafilácticas, angioedema, broncoespasmo alérgico, erupción cutánea y urticaria asociadas a darbepoetina alfa.

Se han notificado reacciones adversas cutáneas graves (RACG), incluyendo síndrome de Stevens-Johnson (SSJ) y necrólisis epidérmica tóxica (NET), las cuales pueden ser mortales o potencialmente mortales (ver sección 4.4).

Se han notificado convulsiones en pacientes que reciben darbepoetina alfa (ver sección 4.4). En pacientes con IRC, la frecuencia se estimó como poco frecuente a partir de los datos del ensayo clínico.

*Pacientes con cáncer*

En la experiencia postcomercialización, se ha observado hipertensión en pacientes con cáncer (ver sección 4.4). La frecuencia a partir de los datos del ensayo clínico se estimó como frecuente en pacientes con cáncer y también en los grupos placebo.

En la experiencia postcomercialización, se han observado reacciones de hipersensibilidad en pacientes con cáncer. Se estimó la frecuencia de todas las reacciones de hipersensibilidad a partir de los datos del ensayo clínico como muy frecuente en pacientes con cáncer. Las reacciones de hipersensibilidad también se notificaron como muy frecuentes en los grupos placebo. Se han notificado reacciones graves de hipersensibilidad, incluyendo la reacción anafiláctica, angioedema, broncoespasmo alérgico, erupción cutánea y urticaria asociada a darbepoetina alfa.

Se han notificado reacciones adversas cutáneas graves (RACG), incluyendo síndrome de Stevens-Johnson (SSJ) y necrólisis epidérmica tóxica (NET), las cuales pueden ser mortales o potencialmente mortales (ver sección 4.4).

En la experiencia postcomercialización, se han notificado convulsiones en pacientes que reciben darbepoetina alfa (ver sección 4.4). La frecuencia se estimó a partir de los datos del ensayo clínico como poco frecuente en pacientes con cáncer. Las convulsiones fueron frecuentes en los grupos placebo.

*Insuficiencia renal crónica en población pediátrica*

No se identificaron reacciones adversas adicionales en pacientes pediátricos, en comparación con aquellas que previamente se notificaron en pacientes adultos, en ningún estudio en insuficiencia renal crónica en pacientes pediátricos (ver sección 5.1).

Notificación de sospechas de reacciones adversas

Es importante notificar sospechas de reacciones adversas al medicamento tras su autorización. Ello permite una supervisión continuada de la relación beneficio/riesgo del medicamento. Se invita a los profesionales sanitarios a notificar las sospechas de reacciones adversas a través del sistema nacional de notificación incluido en el [Apéndice V](http://www.ema.europa.eu/docs/en_GB/document_library/Template_or_form/2013/03/WC500139752.doc).