El medicamento RIVAROXABAN STADA 15 MG COMPRIMIDOS RECUBIERTOS CON PELICULA EFG con los principios activos RIVAROXABAN tiene la siguiente información en la sección 4.8
Resumen del perfil de seguridad

Se ha evaluado la seguridad de rivaroxabán en trece estudios pivotales de fase III (ver Tabla 1).

En total, 69.608 pacientes adultos en diecinueve estudios de fase III y 488 pacientes pediátricos en dos estudios de fase II y dos de fase III fueron expuestos a rivaroxabán.

## **Tabla 1: Número de pacientes estudiados, dosis total diaria y duración máxima del tratamiento en los estudios pediátricos y en adultos de fase III.**
          **Indicación**  **Número de pacientes \***  ****

          **Dosis total diaria**  **Duración máxima del**

          **tratamiento** 
        
 Prevención de tromboembolismo venoso (TEV) en pacientes adultos sometidos a cirugía electiva de reemplazo de cadera o rodilla  ****

          6.097  ****

          10 mg  ****

          39 días 
 Prevención del TEV en pacientes encamados  3.997  10 mg  39 días 

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          Tratamiento de la trombosis venosa profunda (TVP) y de la embolia pulmonar (EP) y prevención de las recurrencias  ****
          6.790  Días 1 a 21: 30 mg

          Día 22 en

          adelante: 20 mg Después de al menos 6 meses: 10 mg o 20 mg  ****
          21 meses 
          Tratamiento del TEV y prevención de recurrencias del TEV en recién nacidos a término y en niños menores de 18 años tras el inicio de tratamiento anticoagulante estándar  ****
          329  Dosis ajustada según el peso corporal para lograr una exposición similar a la observada en adultos tratados por TVP con 20 mg de rivaroxabán una vez al día  ****
          12 meses 
 Prevención del ictus y de la embolia sistémica en pacientes con fibrilación auricular no valvular  ****

          7.750  ****

          20 mg  ****

          41 meses 
          Prevención de acontecimientos aterotrombóticos en pacientes que han padecido un síndrome coronario agudo (SCA)  ****
          10.225  5 mg o 10 mg respectivamente, administrado conjuntamente con AAS o bien con AAS más clopidogrel o ticlopidina  ****
          31 meses 
          Prevención de acontecimientos aterotrombóticos en pacientes con EAC/EAP  ****

          18.244  5 mg administrado conjuntamente con AAS o bien solo 10 mg  ****

          47 meses 
          3.256\*\*  5 mg administrado conjuntamente con AAS  ****

          42 meses 

\*   Pacientes expuestos por lo menos a una dosis de rivaroxabán.

\*\*   Del estudio VOYAGER PAD.

Las reacciones adversas notificadas con mayor frecuencia en los pacientes que recibieron rivaroxabán fueron hemorragias (tabla 2) (ver también sección 4.4. y “Descripción de las reacciones adversas seleccionadas” más adelante). Las hemorragias notificadas con mayor frecuencia fueron epistaxis (4,5%) y la hemorragia del tracto gastrointestinal (3,8%).

## **Tabla 2: Tasas de acontecimientos de hemorragia\* y anemia en los pacientes expuestos a rivaroxabán en los estudios pediátricos y en adultos de fase III finalizados**

 **Indicación**  **Cualquier hemorragia**  **Anemia** 
      
 Prevención del tromboembolismo venoso (TEV) en pacientes adultos sometidos a cirugía electiva de reemplazo de cadera o rodilla  6,8% de los pacientes  ****

          5,9% de los pacientes 
 Prevención del tromboembolismo venoso (TEV) en pacientes encamados  12,6% de los pacientes  2,1% de los pacientes 

  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 Tratamiento de TVP, EP y prevención de recurrencias  23% de los pacientes  1,6% de los pacientes 
          Tratamiento del TEV y prevención de recurrencias del TEV en recién nacidos a término y en niños menores de 18 años tras el inicio de tratamiento anticoagulante estándar  ****

          39,5% de los pacientes  ****
          4,6% de los pacientes 
 Prevención de ictus y de embolia sistémica en pacientes con fibrilación auricular no valvular  28 por 100 pacientes-años  2,5 por 100 pacientes- años 
 Prevención de acontecimientos aterotrombóticos en pacientes después de un SCA  22 por 100 pacientes-años  1,4 por 100 pacientes- años 
 Prevención de acontecimientos aterotrombóticos en pacientes con EAC/EAP  6,7 por 100 pacientes-años  0,15 por 100 pacientes-años\*\* 
 8,38 por 100 pacientes-años#  0,74 por 100 pacientes-años \*\*\* # 

\*              Para todos los estudios de rivaroxabán se recopilaron, notificaron y adjudicaron todos los acontecimientos de hemorragia.

\*\*              En el estudio COMPASS existe una incidencia baja de anemia debido a que se aplicó una estrategia selectiva para la recopilación de acontecimientos adversos.

\*\*\*              Se aplicó una estrategia selectiva para la recopilación de acontecimientos adversos. #              Del estudio VOYAGER PAD.

Tabla de reacciones adversas

Las frecuencias de las reacciones adversas notificadas con rivaroxabán en pacientes adultos y pediátricos se resumen en la Tabla 3, según la clasificación por órganos y sistemas (convención MedDRA) y según las frecuencias.

Las frecuencias se definen como: muy frecuentes (≥ 1/10), frecuentes (≥ 1/100 a < 1/10), poco frecuentes (≥ 1/1.000 a < 1/100), raras (≥1/10.000 a < 1/1.000), muy raras (< 1/10.000) y frecuencia no conocida (no puede estimarse a partir de los datos disponibles).

## ****

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/wqf4Wf9E08K/+Ca2/+Irs6KAPIPh78Mvhte+F7ya8+Hvhq5lXXNYhDy6TbuQialcoi5KdFVVUDoAABwKrWcf7ON9peu6la+C/Dbw+HzjU4z4X2zWnJB3RGASYBDZO3C7WzjBrtfhp/wAijff9jBrf/p1uq8H8WaC+qfDjW/iT8O7y1vNRhuNc0zV0tpBIt7p895cNztOCyJIkyk9VIPTFAHuVr8L/AIT3llBdw/DPwysc8ayKJdBhicAjI3I0YZT6ggEdCKm/4VP8LP8AomnhX/wTW3/xFeW/GnxBqmm+Pru0uvE2saFpUfhO4u9KNjLJAlzqwlISPcg/ett2/uySOenNdV411rxtZ/sry67YNex+KxotrNcPFABcRuRH9oYJj5WCmQ9BtI7YoA6j/hU/ws/6Jp4V/wDBNbf/ABFH/Cp/hZ/0TTwr/wCCa2/+IryTX9Y02yu/BEdh8QvE3/CBale38mparJfTZjYWyNBELvbvCb92BvOW3qSduBieHvEGtatffBS08V+MNZsb7WbfUY9UhbUpLKS5iBdbMyRhl2s54VwA7nGGJAwAe7f8Kn+Fn/RNPCv/AIJrb/4ij/hU/wALP+iaeFf/AATW3/xFeB6J441LVfAPwok8R+N9UtdEuJ9Ut/EGpW128ciSRhjaxzzp86MQVIBILggnNL4Z8S+KdWPgax+IvirxPoun3/h24mt7y1L2s1zfLelUDbUzK5txGQhVg27OCWzQB7Ro/gb4K6//AGh/ZPw/8K3P9nXkmn3P/EihTy548b0+aMZxkcjI9DVfw34R+B/i2zvLrQfh/wCGbiOyunsbgS+HY7d4Z0ALRskkSsCNwzx7djXkEXjLUG8FavDp/jXU5dLg+Ios7y9g1CS5mtdFbhW84l3jhOziQEZw2G5NVfCOuaLCNY0MeJ9ciivPG+pgXdpeyQoI2iURS3UkY80lireUoZBK6tknaaAPoT/hU/ws/wCiaeFf/BNbf/EUf8Kn+Fn/AETTwr/4Jrb/AOIrI+BPiLUvFHwS0DVNZ1N9S1PE0NzNLjzMpM6qHAAw2wJ1GTkE9c16VQBxn/Cp/hZ/0TTwr/4Jrb/4ij/hU/ws/wCiaeFf/BNbf/EV2dFAHGf8Kn+Fn/RNPCv/AIJrb/4ij/hU/wALP+iaeFf/AATW3/xFdnRQB+SnxNtLWw+MPjSxsbWK1tLbXL2GGCFAkcSLcOFVVHAAAAAHAFFTfFj/AJLf48/7GC//APSl6KAP0G+GVh8SX+D3gt7HxZ4agtG0OyMMU3h64lkRPs6bVZxeqGIGASFUE84HSus/s34p/wDQ5eFf/CZuf/k+vJ9U1Dxf4W/ZX8OeNPD3i+401bDwvo8cNhHZ28kbSt5SPI7SIzHKSKAo2gFM85xXpOqeKJvhnDp8XinUNZ8URa3q6WNndx2lsr2rSKoSKQRmPfllkbeqHjIPRdwBf/s34p/9Dl4V/wDCZuf/AJPo/s34p/8AQ5eFf/CZuf8A5PrF1L4zaPodj/aGv+EvFOj2EciRXF1e2Cxpbs7sij7+6T7uSYhIAGXJGcVpXXxQ0iH4i3HgW10fV9S1O0e2W6e0iiZLcT42yMDIJCiggu6oyqOp7UAWP7N+Kf8A0OXhX/wmbn/5Po/s34p/9Dl4V/8ACZuf/k+uS0P4zY0jx54i8V6BqOl6L4c1aayWYCGbb5fkxiHEchdpWkdmzt2ANjfxV6/+N3h7S/D/AIg1W+8PeIIJfDk1vHqlg9vELi1WcZikx5u11bgfIzMCRkAZIAN/+zfin/0OXhX/AMJm5/8Ak+j+zfin/wBDl4V/8Jm5/wDk+su6+LVraeJ9P8PTeCfFC3mqS3ENhm2gVbswxiRiu6YELtZcMwA5wSCrAZ3/AAvzwdLpNlqNhpuuaiLjTJdYlhtrRS9paRStFJLJlwvDowwpYnGQCMUAdL/ZvxT/AOhy8K/+Ezc//J9H9m/FP/ocvCv/AITNz/8AJ9Zdr8YvDep+LIfDuiaXq+rzPHZTvPaQR7IYrpVaKVkd1k2BWBdghCA84PFVvip8Ro/Denat4f0dtV/4SWPRZ9Yjl0+1jlW0ijyBLJ5oK7C67SAGbBOAODQBu/2b8U/+hy8K/wDhM3P/AMn0f2b8U/8AocvCv/hM3P8A8n1y9t8YtP0Xwj4bGuWmq6zrVx4Zg8QagdPtUbybfy18yd8lFA3bvlTJ9FxirPxb8X6hp/wHufHXgvW5bOQR2t5a3CQRsJopZEUBklRsArJu6BgQOcZBAN/+zfin/wBDl4V/8Jm5/wDk+j+zfin/ANDl4V/8Jm5/+T6rX/xS0XSvFln4f1TR9asVvtRGlWt/PaBLe4uCBgIN3mFCTgSbNhPRqt+M/iHpHgm/0XTr6yvr6+1uSWOzt7MRBpDGoZhmV0XOCAFzuYnABNADf7N+Kf8A0OXhX/wmbn/5Po/s34p/9Dl4V/8ACZuf/k+svW/i/ovhuzg1DXPDfiTT9OaO2knvLiwCR2rTjKxsC4d3Xo4jV9h4JzVfWPjXoGg6p4lsdS8P69GvhqW2TUbhYYWiiSc4ilBEuWVsqcAbwGGV4OADc/s34p/9Dl4V/wDCZuf/AJPrM8Q+E/iT4l8K6t4cvvG3hqO01Wzmspnh8N3AkVJEKMVJviAcMcZBGexo8WfGDw94Rv8AWLWfStW1MaGlu2pzWMcXl2ZnOIlcySISW4PyggAjJFZsnx48NWularql/wCHPElpZaPfTadqEzWccqWs8YX5GMcjA7mYIpXI3dSAQSAdL/ZvxT/6HLwr/wCEzc//ACfR/ZvxT/6HLwr/AOEzc/8AyfVnwn460zxbf6xpkOn6jpeq6M8S3thqMIjliEqb42yrMhDKCeGJGOcVz1z8YtKtvEWseH28L68+p6TPbwSWyi1Dzee+yJ4g04LqTjnsDk4wcAGx/ZvxT/6HLwr/AOEzc/8AyfR/ZvxT/wChy8K/+Ezc/wDyfUvjPxnp/hufTNCaPVZ9X17zobCLSrdJZx5abpJR5n7sbAQ3zZz/AHW5FcB4B+L0zfCjwTfeJo9S8Q+JvErXi29vp9pGJbgQSybjj5I0CoF6kE+hOaAO6/s34p/9Dl4V/wDCZuf/AJPo/s34p/8AQ5eFf/CZuf8A5PrkF+I03iD4ifC2+8K61cnwx4qh1H7RZTW0aZa3iJB+ZPMVg5IOG2nYMcElun8V/FDSPCniuDwu2j6vrGrz2LagtrpsUTu0QfYdqvIhkbIPyoGbAJxigCx/ZvxT/wChy8K/+Ezc/wDyfR/ZvxT/AOhy8K/+Ezc//J9c3N8UbPw/rXxLv/EN1qn9neF/sW6xaygHkCVSFaKRJCZRIdr/ALzZsBAOOcQ+Jvi5qFnoPh+/0fwbrCtqviK10gfaPsw3o5SQtERMUkEibkRw23IYlhtGQDqv7N+Kf/Q5eFf/AAmbn/5Po/s34p/9Dl4V/wDCZuf/AJPrC/4Xb4d/tL7D/YOvhv7R/sXzfs8Xlf2ls3fY93mY8zPy7v8AVZ/j2/NVbS/jx4c1m20mXT/DPiaWTWo530yH7HHuvTDJtmRD5m0FAC53EAqOCTxQB039m/FP/ocvCv8A4TNz/wDJ9H9m/FP/AKHLwr/4TNz/APJ9c23x68Hr4etvEw0vX/8AhHZvKDaq1hsgiZ3ZNuGYPIVZSG8pXC9zWh8Ute13w9eeBJ9F1aSzj1DxNZ6XeQCKJ0uIJSSwJdCykbMAqV+83XggA1P7N+Kf/Q5eFf8Awmbn/wCT6P7N+Kf/AEOXhX/wmbn/AOT64fw38Zl/4SK68P6hpXiXVtRvtav7Oyi+xWcX2drdFd7TKXBDeWCP3rYDbuvBIqa58U9a8W6t8OtO+H8mo6Tp/i9b1jqf2W1klhaFSNvlyuRhHG6QY+ZcCNieKAOwh8J/EmDxVf8AiNPG3ho3d9Z21lIh8N3HlhIHndCB9uzkm4fPJGAuAOc6f9m/FP8A6HLwr/4TNz/8n1zegfEZh4zg8P61/wAJC1/qNm/9mWl3pcNmt41up81wN5dHkKsyiXy127cD+I85onxf1zxB4O8E63e6dq2gR674iWzW6it7O5guI2uJUS1OZhIg2KAZfLyDGSAcjIB6P/ZvxT/6HLwr/wCEzc//ACfR/ZvxT/6HLwr/AOEzc/8AyfS6X8RNL1vxhd+HdK0jWLuOzvJdPuNUjtQbOK5iQO8TPu3AjIGSu0twCTWX4a+MfhbxRrulaXY2erQR619p/sq9ubXZBf8A2cnzfLIYsMYP31XOOKANP+zfin/0OXhX/wAJm5/+T6P7N+Kf/Q5eFf8Awmbn/wCT67OigDjP7N+Kf/Q5eFf/AAmbn/5Po/s34p/9Dl4V/wDCZuf/AJPrs6KAOM/s34p/9Dl4V/8ACZuf/k+j+zfin/0OXhX/AMJm5/8Ak+uzooA4z+zfin/0OXhX/wAJm5/+T6P7N+Kf/Q5eFf8Awmbn/wCT67OigDjP7N+Kf/Q5eFf/AAmbn/5Po/s34p/9Dl4V/wDCZuf/AJPrs6KAOM/s34p/9Dl4V/8ACZuf/k+j+zfin/0OXhX/AMJm5/8Ak+uzooA4z+zfin/0OXhX/wAJm5/+T6zPD3hP4k+GvCuk+HLHxt4aktNKs4bKF5vDdwZGSNAiliL4AnCjOABnsK9GooA4z+zfin/0OXhX/wAJm5/+T6P7N+Kf/Q5eFf8Awmbn/wCT67OigDyfSPh38RdJ8T6h4if4i6Rqd9dtIY/7Q0O5mWyjkZWeKAfbxsQlE45+6K6X+zfin/0OXhX/AMJm5/8Ak+uzooA4z+zfin/0OXhX/wAJm5/+T6P7N+Kf/Q5eFf8Awmbn/wCT67OigDjP7N+Kf/Q5eFf/AAmbn/5Po/s34p/9Dl4V/wDCZuf/AJPrs6KAOM/s34p/9Dl4V/8ACZuf/k+j+zfin/0OXhX/AMJm5/8Ak+uzooA4z+zfin/0OXhX/wAJm5/+T6P7N+Kf/Q5eFf8Awmbn/wCT67OigDjP7N+Kf/Q5eFf/AAmbn/5Po/s34p/9Dl4V/wDCZuf/AJPrs6KAPOdD8J/Enw/p0tjZ+NvDUkUt5dXpMvhu4J33FxJO44vhwGlYDvgDJJ5On/ZvxT/6HLwr/wCEzc//ACfXZ0UAcZ/ZvxT/AOhy8K/+Ezc//J9H9m/FP/ocvCv/AITNz/8AJ9dnRQBxn9m/FP8A6HLwr/4TNz/8n0f2b8U/+hy8K/8AhM3P/wAn12dFAHGf2b8U/wDocvCv/hM3P/yfR/ZvxT/6HLwr/wCEzc//ACfXZ0UAcZ/ZvxT/AOhy8K/+Ezc//J9H9m/FP/ocvCv/AITNz/8AJ9dnRQBxn9m/FP8A6HLwr/4TNz/8n0f2b8U/+hy8K/8AhM3P/wAn12dFAHGf2b8U/wDocvCv/hM3P/yfR/ZvxT/6HLwr/wCEzc//ACfXZ0UAcZ/ZvxT/AOhy8K/+Ezc//J9H9m/FP/ocvCv/AITNz/8AJ9dnRQB+SnxNW6T4w+NEvpop7tdcvRNLDEYo3f7Q+5lQsxUE5IBZiBxk9aKm+LH/ACW/x5/2MF//AOlL0UAfoDZeC7n4g/speD/CcGrx6VHe6HpZmne1NwdiQxOAo3pg7lXkk8ZGOcjqPG/gjW/GFl4WRfEVlY3WhajBq0kh015UubiIfLhfPUpGSz5Xcx5HzDBJ4/wR4G+E9l8AvDXinxH4F8NNFB4btdQv7ybR4ZpCFtVkkkb5CznhiepJ9TXc/wDCp/hZ/wBE08K/+Ca2/wDiKAOa8ffB+88bXfiJ08Zz2Ntrlta27wTWaXAthBIJAIWLKURiMsvdsHPGKt658LLrxD8QdD8Yah4ihjutIvYrqJrXTxDN5axKr2/miTJidw7kOHOG2gjBLbX/AAqf4Wf9E08K/wDgmtv/AIij/hU/ws/6Jp4V/wDBNbf/ABFAHL3nwW+36B458Oz+LLlNI8VX8mpiGK1jD2tw8kchYuSd4BiUAYXgtnJwRU1j4J6prmg+MLfUPG0cmq+LprJr+8/ssCNIrUDy0iiEoKsSFyzOwIyAozkdbd/C34YW1jPcQ/Cnw1eSxRs628Oj2gkmIGQilwq5PQbmAyeSBzU3/Cp/hZ/0TTwr/wCCa2/+IoAra14I1vWfH3gzxZJ4isYpPDSSh7ddNci6eZAk5B8/92CoGwYbaeSX6V5/pv7PWpaVoyWNn4/WOQ6Pc+H5pRpIIksp5mmYBTKdsoeR8PnGNo2ZBLd5qnw7+Dui6XNqWpfDvwrDbRYBI0OB2ZmYKqIqxlndmKqqKCzMwUAkgUad8M/hpfW5lufg94f0xxs/dXWkWLMcxqx/1e8fKWKHn7yNjK7WYAxJPgtG/iPwnqieIykfhaS2Fky2SpdfZoYEj+ztOjLvR2Vnbcrfe2rtGc6Xjj4X3HirxJd69pniZ9Hub/QZ/D10j2a3KPbyMW3KNylXDN1yQRxgda1v+FT/AAs/6Jp4V/8ABNbf/EVjWXgv4O3/AIv1jwvD8LvD63ukW9tczyS+H4EidZzLs8tinz48lslcqCcZLBgoBkTfA+O4fwze3OqaTf6jomjDQnOoaIt1bT26tmN1heQmOVf74Ygkn5cHbXU+O/h+/i74WHwDp+rQ6RausELTtZLJiKIqyqiI0aoconQbQMgKMgif/hU/ws/6Jp4V/wDBNbf/ABFH/Cp/hZ/0TTwr/wCCa2/+IoA5G/8Ag5reoatFqdx4882ZNftvERE2mBx50KbfJB8wMIBk7E3EoCRubOa6b4mfD1viNoX9izanbWtkYZVaO4sBc4mYp5cyNuV0eMB8bWGS/OQNpsf8Kn+Fn/RNPCv/AIJrb/4ij/hU/wALP+iaeFf/AATW3/xFAHF+JfgffeINK1HTf+E/vRBqGm2OnyG9tFunT7MysGRiylRIV3Ov8THOeMU7XfgvrHiIePP7Q8Y2af8ACYrZCbyNJZfszWroYyubg7gVVgwPUkEEAbT2X/Cp/hZ/0TTwr/4Jrb/4ij/hU/ws/wCiaeFf/BNbf/EUAeMeOtD8ZN8T9VvV8NaRqodbPdJc6Vqxhv3jhQ5KWpeF1Em7AnJZehJVQT2ujfCK/wBU+Ffivw34x1WNZPGVydYuorS18ttPu5dkjoGMjiRFdEA4GQrZJ3DHZf8ACp/hZ/0TTwr/AOCa2/8AiK5P4m/DL4bWHwe8aX1j8PfDVrd22h3s0M8Ok26SROtu5VlYJkEEAgjkGgDsvBPguHwjbXfy6QLm68sSNpOkRadEwQEAlVLMzEsxJLEc/KF5zx58PReMP2gtN8Ynw9qulr4WhurGa41CARRX7kgQtEMneg3TMH4wdvTitHxD4O+Cvhe3s5tX+G/h/wD024+y28Vn4ZW8lll8t5Nqxwwu5+SN2JxgBTWLo9r+z7rmqWWnWHw50pZr64mtLdrrwXLbRSTRLI0kXmy2yoHUQy5UtnKMOoxQB2fi/wAEXHiPxN4Y8TabrjaTqvh2SdoGa3W4ilSaMJIrISpzgcEMMHsa4Sz+ASQeDvCWi3mvWGqXXhS5uZbOW+0dZreeKfJkjngaUhzuJIZWTGBxkZPd/wDCp/hZ/wBE08K/+Ca2/wDiKP8AhU/ws/6Jp4V/8E1t/wDEUAY5+F91D4o8D6vp2tafZW3hQXG2zi0hY1na4yJ8eXIixjaflAUkHJYyZNL8SfhbJ8Rbi2abX006K0aCS1dLENc2cqSMzywzh1ZWddi4OVAUnaSQQ3xF4L+DvhizsbnUPhd4flS91C102MW3h+CTbLPKsSM5CYRAWGWYgdhlmVTs/wDCp/hZ/wBE08K/+Ca2/wDiKAMYfDXWh4r8aa2PFNkI/FbWomtzo4kEUcBCiP8AeSsrh4d6NlerBhtxtOPZ/A7+zvAmn+HLDxQbebTfEa+IrKQWha3tXUnbAkLSkiIZPG/OST3xXY/8Kn+Fn/RNPCv/AIJrb/4iqVz8OPhNY/bZtQ+GXhWysLO3FzJf3GlWaQBfnL5JGV2BAzFgFw4wThtoBh6b8FYdH8Tajrdnqel3Vxe339q/adS0KG5u47vaCWWYFcRmRQ5RVUjkI6ZyIfDPwZ1Lw3/wgXl+Lra5/wCEOnvmi3aWy/aYrrG9G/fnawzJhhkfMuVO07uv/wCFT/Cz/omnhX/wTW3/AMRR/wAKn+Fn/RNPCv8A4Jrb/wCIoA8ps/2bNUtfBeq+FX+JTz2d/DFbrv0lT9mSO48/bHmUlVZyxYAjJ2njbz6f478E6x4yt/DKweILPTptD1KHVmd9PaZZ54h8gAEy7Uyz5GSTkYYYOVtPhb8MLmxguJvhT4as5ZY1drebR7QyQkjJRigZcjodrEZHBI5qb/hU/wALP+iaeFf/AATW3/xFAHFaH8Ftc0j4gWPi2XxpY3LW2r32sNbro7oHe8REnQN9pOBtQbOCVOSd44pfC/wX1vw1eeBmHjOxurbwe92beP8Asd0edLonzg7faCM4J2kLxxkN0rtP+FT/AAs/6Jp4V/8ABNbf/EUf8Kn+Fn/RNPCv/gmtv/iKAOW0f4PalpPi3w1rreN5NRXQby+uUS8sFaa5F0MP5squpZwOA+MYCjbxzQt/gjrdj4V8N+G7Lx3CbDw5q66vZLc6RvIdJJJEVisyk5Mr7jnkBNoTDbrmn/DL4bP8YfEdi/w98NNaQ6Hpc0cB0m3MaO9xfh2C7MAsEQE9SEXPQV1n/Cp/hZ/0TTwr/wCCa2/+IoAg8L+Abvwp4t1/UtP8Syto2tajJq0umPbKWW4kQK/70n7hIDBQoIIHzEZB53wh8Fz4W13w1cy+LJ9Q0zwr9t/smzNokbp9qJ8zzpAT5mATjCp+NdT/AMKn+Fn/AETTwr/4Jrb/AOIo/wCFT/Cz/omnhX/wTW3/AMRQB2dFcZ/wqf4Wf9E08K/+Ca2/+Io/4VP8LP8AomnhX/wTW3/xFAHZ0Vxn/Cp/hZ/0TTwr/wCCa2/+Io/4VP8ACz/omnhX/wAE1t/8RQB2dFcZ/wAKn+Fn/RNPCv8A4Jrb/wCIo/4VP8LP+iaeFf8AwTW3/wARQB2dFcZ/wqf4Wf8ARNPCv/gmtv8A4ij/AIVP8LP+iaeFf/BNbf8AxFAHZ0Vxn/Cp/hZ/0TTwr/4Jrb/4ij/hU/ws/wCiaeFf/BNbf/EUAdnRXGf8Kn+Fn/RNPCv/AIJrb/4ij/hU/wALP+iaeFf/AATW3/xFAHZ0Vxn/AAqf4Wf9E08K/wDgmtv/AIiuT+GXwy+G1/8AB7wXfX3w98NXV3c6HZTTTzaTbvJK7W6FmZimSSSSSeSaAPX6K4z/AIVP8LP+iaeFf/BNbf8AxFH/AAqf4Wf9E08K/wDgmtv/AIigDs6K4z/hU/ws/wCiaeFf/BNbf/EUf8Kn+Fn/AETTwr/4Jrb/AOIoA7OiuM/4VP8ACz/omnhX/wAE1t/8RR/wqf4Wf9E08K/+Ca2/+IoA7OiuM/4VP8LP+iaeFf8AwTW3/wARR/wqf4Wf9E08K/8Agmtv/iKAOzorjP8AhU/ws/6Jp4V/8E1t/wDEUf8ACp/hZ/0TTwr/AOCa2/8AiKAOzorjP+FT/Cz/AKJp4V/8E1t/8RR/wqf4Wf8ARNPCv/gmtv8A4igDs6K4z/hU/wALP+iaeFf/AATW3/xFH/Cp/hZ/0TTwr/4Jrb/4igDs6K8g+Hvwy+G174XvJrz4e+GrmVdc1iEPLpNu5CJqVyiLkp0VVVQOgAAHArrP+FT/AAs/6Jp4V/8ABNbf/EUAdnRXGf8ACp/hZ/0TTwr/AOCa2/8AiKP+FT/Cz/omnhX/AME1t/8AEUAdnRXGf8Kn+Fn/AETTwr/4Jrb/AOIo/wCFT/Cz/omnhX/wTW3/AMRQB2dFcZ/wqf4Wf9E08K/+Ca2/+Io/4VP8LP8AomnhX/wTW3/xFAHZ0Vxn/Cp/hZ/0TTwr/wCCa2/+Io/4VP8ACz/omnhX/wAE1t/8RQB2dFcZ/wAKn+Fn/RNPCv8A4Jrb/wCIo/4VP8LP+iaeFf8AwTW3/wARQB2dFcZ/wqf4Wf8ARNPCv/gmtv8A4ij/AIVP8LP+iaeFf/BNbf8AxFAHZ0Vxn/Cp/hZ/0TTwr/4Jrb/4ij/hU/ws/wCiaeFf/BNbf/EUAfmb8WP+S3+PP+xgv/8A0peiofibaWth8YfGljY2sVraW2uXsMMEKBI4kW4cKqqOAAAAAOAKKAPuXRfE1rqfgX4Q/D7QtQ0XUNdTS9P1W70m91MWwkS2tIZYo2ZEklSTzXt7hVCYdLeTJ25DU7vxxpOk/DOPwRJ8SNP8K674a8SWWmSRaZqtuxjsxeQ4iR5k3SRwW0qxu7opL20gk3LvD+v/AAn/AOSIeA/+xfsP/SZK7OgD551fxAzQa34U0j4gRWGj6R4sSwvdQvdRmuDp9mdM83E9ytxHOoN8GjDGdTv/AHWSoMRnhvbCTxZ4Q0XxB8Ybu50yTw/qt1MLe+bSo7qKK6iaCUMXNwUEQlKz+cxkjtS4dkeYye/0UAfKeqfEFbf4XWWoP8WJYdb8SeA73Vbqc6pCsjahH9nEEcEeNkB3G7h2wojsUckmWPevW+OPiBYaX44tNXtfFFpaQjUNLWOe+8TNbJNYzSQebLa2Kr5F1bGKWXNxIxZXE2CBBHj3+obm6jtIVllWVlaRIgIoXlOXcIDhQSBlhluijLEgAkAHJeOP+Qv4G+0f8g3/AISBPtnmf6n/AI9bn7P5meP+Pr7Nsz/y18rHzba8mvfE1nf/ABVbwvL8XLuJZPHEtlJY2+qwRSPbPo6nyBtUOiLchoF2FSJHJyZwsi+/6ppdhrWlzabqUHnW0uCQGZGVlYMroykMjqwVldSGVlDAggGp7SGS2sYLea7lvJYo1RriYIJJiBguwRVXJ6naoGTwAOKAPBtL8YaDrdhoia/488rwjBca7aPqUWvPZqZoL6NLCKS8jkV3c2jSOFaQmVf3jbyocdZ4d8SaAnxh1u1n8SxS3f8Awjehxt/aDpb3Tu1xdgebCVQpIxuLfKbFIaeMbRuUV6nRQAUUVDNd2ttNbQ3FzFDLdSGGBJHCmZwjOVUH7x2o7YHOFJ6A0ATUUUUAFFFFABXGfFj/AJIh48/7F+//APSZ67OuM+LH/JEPHn/Yv3//AKTPQB2deDSeJtPf9lz4ga1oPjCKya2vNfeHUdPu4spK1/cSQor8gGQSRBcYYiVShBKtXs1zr2mWurLpMksst8Y0maG3t5JjGjyiJGfYp2AsTgtgERyt92KQrp0AeQa1/wAI7pd94bj1rxzqEfg/VLO81CbWrjxFNax3d6Ta/ZytzHIgQPE1y6wRFIiAzLH8g2+f3nivU49J8Tat4j+IuoWfiPRvAel6wNJkvo7MWmqmKfO+BAhJ8wwboZMqxuUV0YeSqfRniDxBo3hbw7e+IfEOoRadpdjH5s9xKeEHQDA5JJIAUAliQACSBWnQB88+IdW0+afxB4X0nx9LqVvBH4b15rw6hFdzW+7U/Mur0bgyRxrAltMVCiCNSrBFVzu6BNYmX4eeJ5dE167vPDUHiCxt7PVVv5Ln/iVubL7dIt4zM5RDJe7pvMJi2Phk8obfZqKAPDP7at/7K8v/AISq7/4V9/wlH2b+2v7Yl2fYP7L83P8AaPmeZs/tD93v837/AO5zj93WBr+raNqvh34veHrHx9qHiCwi8Fx3tlb3GofvIAn20nYUCPJGVFqTI5czRyRF3kSRSfpKigDwDxPrWnWdnqn9i+KtVhjt/D63Pg3ztYug+q6kZbzcI/Mk3ajlks9qP5yFJI9g2TDfs6trFg/xmv7W48cXcD2HmeZ9h1RoDosX9nly11ZyIYJLYb/OF224iaWGIgqmK9mooA+c73xVb6l8GPhtLd+NruWbUfD5aS3sNZls9Q1C5SKBJHtp4wxnvI3Z0W0cgSyS/NzFX0ZRWY3iDRl8VReFjqEX9tS2b6gtmDmQW6usZkOPujc4AzjcQ2M7WwAadFFFAHGab/yW/wAUf9i/pH/pTqVdnXGab/yW/wAUf9i/pH/pTqVdnQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFcZ8J/8AkiHgP/sX7D/0mSuzrjPhP/yRDwH/ANi/Yf8ApMlAHZ0UUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAcZ8NP+RRvv+xg1v8A9Ot1XZ1xnw0/5FG+/wCxg1v/ANOt1XZ0AFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFAH5NfFj/kt/jz/sYL//ANKXoo+LH/Jb/Hn/AGMF/wD+lL0UAfeXwlk8Wajb+GtJPir7FoGneD/D2oRWdpYxCWRpI5keOSWTflG8g7tqq2PL2shVzLP4M8SfEy68KnxRr2u+GreLWfDcmtWMOoagDHbS7I5FbYltC0Vqnm4l3yTsoMQD53M+n4AXwP4N+CHhn4iaxZ6VpE0fhfTxfay1sizvELaEBGkA3vkrGqpySQgAJwK9Ag8J+FbX+1/s3hnSof7b3f2n5dnGv2/du3edhf3ud753Zzub1NAHksniHxfbz6DprfEC7077b4obRtQGu6bZfbrPzNNM0VuJICLZnLBZEZVfLXESsG8t45J5vEfxF10aD4d8O6lEl88muC5vmnitJpk0+/SzjYs1rcR5dZNzhYVBblSijY3Qa94c8N3Xifwl4E0W78P6TDpX2jWZfDn9lCVLq0ZHtZRtR0SJGF3KPmVt7nIBCOD0Himy+Hlp4d0jR/F2laK2jteW2n6bYXtnHLD9of8AdQxxRFSAcMQNo+Vdx4UEgA5iPXPEWsXzC48bafocWk+G9P1qe901IZtOupZzc+Y0jTAs1qPsyldjxMUd8vkqV5mW61zw9418YXem+OJVmufGmmQS6XdQWzie1lXSY5WjwiupRbmOLeSyhMZXzGEo9m1Lw9oGs32n32r6Hp+o3emyedZT3Vskslq+VO6NmBKHKqcjByo9BVLUvBHgvWZrubWPCGi6jLeSRzXL3WnxSmd40KRs5ZTuKqzKpPIDEDg0Aec6JqHi+fx3YeDrjx1qtxf6ZrGoTanJJbWQiu7CKK2khhBW3BD4vbLcQE5a6w3ENGheLvFn9h6Pq8/iO0mm8SeD7rxGBrCRQ2Ol3Ea2rIqtEiuLYG7bf5jSPtjXDAhi3sC2lql9LfJaxLdzRpDJOEAkdELFFLdSFLuQOgLtjqazIPCfhW1/tf7N4Z0qH+2939p+XZxr9v3bt3nYX97ne+d2c7m9TQB5zda94q0/4LfEPU7XxNqDeIdEjuJU/t2wtGuNNKWkc3kuLUiCUlT5iuMhfOUMGKMpmbxTq9imvWMni/8AtWN9P0m/stTs7OB2eW/uZ4BDarkR7GMUYhaZpAjS7pXlQYrrfEPgq1vvhdq3gTwwun+G7TULOayTybENDbpNkSlYUaMZIdyOQNxyQ3INzRNF0aTwq8TaPp/la1GbnUo00v7HHfSzIPNeW3kywL/xLJuYD5WJIoA8ss/EnxE1HUtL8Prrd3ou3xRLol1JqljaT6jJCdI+2qzNAxtlcMX2lUI/1JcNtkSW74g1zWtI8cWd3Y3eq61/ZGoadoFzdNZaelrCLuS0WZbhztuWmdZo5c24SHJgBQ+XJnrdE8DfCeS+e+0PwL4agvtKvDEzxaPDDNa3EZDA8oGQ8o6txlWR1JVlJ2db8EeC/Et8l94j8IaLrN3HGIVnv9PiuJFQEkKGdSQMsxx0yT60AeZ6Tq3xFuodEa+8bxNca14k1Tw+/kaVFHDbQW73zedErFm8/wD0TYjO7xqrLvjlZWdybxH8RddGg+HfDupRJfPJrgub5p4rSaZNPv0s42LNa3EeXWTc4WFQW5Uoo2N6NbfD3wDZ/Yvsfgfw/b/Ybg3dr5WmQp9nmOzMqYX5XPlx/MMH5F9BR/wr3wD/AGH/AGF/wg/h/wDsn7R9r+w/2ZD5Hnbdnm+Xt279vy7sZxxQB4z4i1bxNp154v8AGNp8QbSz1seB9OvoI7SO3uNOvJhFqMjJb708x0AhmmjO8n5iziSNfLHo13B4qXxVo3hGbx1qEcuo2d9q1xqFpZ2iSRtC9pGtvCkkUirB/pEjYcSS5CgykA7ut1Twn4V1y4muNb8M6Vqc09uLSWS8s45mkhEgkETFlJKBwHCnjcAetGoeE/CuraHaaFqnhnSr/SbPZ9msbmzjkgg2KUTZGylVwpKjA4BxQB5lb+MvE2tWfgbW7jXv7GstR0/Rr27XS4beZFmu5QrRXUUxMywzHbDA8PKuZWkO1Aa7P4sf8kQ8ef8AYv3/AP6TPXQTeHtAufEVt4juND0+bWrWMwwajJbI1xCh3AqshG5R878A4+Y+prn/AIsf8kQ8ef8AYv3/AP6TPQBycOpazY+C7nxFpd9Fb3+o+PBbajLJB5huLcauunKijIWMi3igTdtPCE43t5gPCuveNlvvD934g8TRaoNV8SaroMlrDYR21vHFbm/ZJVGWk8zdaKozIV8tsFWcGVuzvvAOgaprN/catpun6tpeoyLeXWm6lZJdRm8SNIUuIy+dh8lfLZcEEKhXYfM8yl4Y8OfCfW9G0/WvCnhfw1c6dbXk01jc2mmwiOO4SQRySwkIMHdAo8xfvCNSCQFNAHC6pqOsap+zprniDWPFv2ybxJ4Hu9VOkTQwJ9mZrQO32Yoqv5KGbYRJ5rfNF86nPme51z7eCPBckOqwyeENFaLWZFm1FDp8RF86uXVpht/eEMSwLZIJJ61p6dpOlaPbm30nTLTT4TszHawrEp2xrGvCgDhI0Qeioo6AUAcYsnizUfjPq+knxV9i0DTtP03UIrO0sYhLI0kt0jxySyb8o3kHdtVWx5e1kKuZeG0Lxp8TLP4dah4817UNFnivPCdx4isdPkuxLIsqRJKojiS3hZIF8za4eWdgWiAkzuZ/ZofD2gW3iK58R2+h6fDrV1GIZ9RjtkW4mQbQFaQDcw+ROCcfKPQUab4e0DRr7UL7SND0/TrvUpPOvZ7W2SKS6fLHdIygFzlmOTk5Y+poA4bxBJ4g8M2EMUPxDu9TuYtY0bzIrm3s/tPkXN8ttIknlxKvkurNsKxo4eN/3jD5V5i+8b+Jr7Wtd8JeE/FdpqWpnxh/ZcTtc28Uthbf2Ybsxhlt5VXbNDPEDJDISEdCd43r61p/hPwrpOh3ehaX4Z0qw0m83/abG2s444J96hH3xqoVsqApyOQMUP4T8KyaHPoUnhnSn0m48vzrFrOMwS+WqJHuj27TtWKJVyOBGgH3RgA85s7r4i6n4m8M+Hbzxxp9lFcaXqj302jQRXcxmtbyCJSJ5UEfmBZVSQfZ1UMJwEBaPyeStvF2sQPrXxPn8R/Z9Sn+H+l6xDo7JAtndXBttRm8gAp5xRTFJKAsofl8sVAC+2TeCPBdzNbTXHhDRZpbWzOnQPJp8TGG1KMhgUlflj2u67B8uGIxgmp9L8J+FdDuIbjRPDOlaZNBbm0iks7OOFo4TIZDEpVQQhclyo43EnrQBi+GbjWLHxxrnhTUddu9dhs9PsdQiu76KBJw08l1G0Z8iONCgFshHybsu+WI2hfIJPHup6bNofjTUfE+n3+tXnw71XxBaaXdJHGbed0s7jyUCFWeD9y+xWBkxDMTI+Pk9/0Tw9oHhqxex8OaHp+jWkkhmaCwtkt42cgAsVQAE4VRnrgD0osfD2gaZfTX2m6Hp9ldzSTTSz29skckjylDKzMACS5jjLE8sUXOdooA5nwGPG1rfarpfjTWNPv5Y44Li3SO+jubqMOZFYyeXa2yrGfLGz92SWWXLEABe5rM0Tw9oHhqxex8OaHp+jWkkhmaCwtkt42cgAsVQAE4VRnrgD0rToA4zTf+S3+KP+xf0j/0p1KuzrjNN/5Lf4o/7F/SP/SnUq7OgAooooAKKKKACiiigAooooAKKKKACiiigAooooAK4z4T/wDJEPAf/Yv2H/pMldnXGfCf/kiHgP8A7F+w/wDSZKAOzooooAKKKKACiiigAooooAKKKKACiiigAooooA4z4af8ijff9jBrf/p1uq7OuM+Gn/Io33/Ywa3/AOnW6rs6ACiiigAooooAKKKKACiiigAooooAKKKKACiiigD8mvix/wAlv8ef9jBf/wDpS9FHxY/5Lf48/wCxgv8A/wBKXooA+xtQ1fU5P2brjTV8RRaNp2lfDPTbkxyxRtHfPd29xCYpC2GB/cIIvLZCJJPmEowlegL4k8ba18Qb7U9B13RY/B+m6pY2CtNqEaw3cU8FrKWCi2dpZH+17YilzGpbygUOG8zZ+HXh7QNb+C3w9m1rQ9P1KWDw3awxPd2yTGNJbRElVSwOA6/KwHDDg5FdnN4e0C58RW3iO40PT5tatYzDBqMlsjXEKHcCqyEblHzvwDj5j6mgDjPGepR6N8RdN1ia+isIrHwnrty11NA88cASXT2LtGhDOBjJVSCQMAgmuG1bWPF91pus+GdRbVbe5s9Q8M3lnceJIbKSdZJ9XCZZbB1jeEG3QhcrISZMtgpj2ybw9oFz4itvEdxoenza1axmGDUZLZGuIUO4FVkI3KPnfgHHzH1NZmn/AA98A6T9r/svwP4fsPtlu9pc/ZtMhj8+F8b4n2qNyHAyp4OKAOM/tzxN/aX/AAhf/CSXfmf8JR/Yn9teRb/bfJ/sj+0d2PK8jf5n7vPlY8vtv+eqWl6x478ReKdE0NfGP9m2ElvrsNxPb6fC15M9hqUdrHNvcNErujKWAh2cy4UbozD6b/wifhX/AIRj/hFv+EZ0r+wP+gX9jj+y/f8AM/1W3Z9/5unXnrRF4T8Kwapp+qQ+GdKiv9MtxaWV0lnGJbSEKVEUT7cogDMNqkDDEd6APOW8T+JLn4g2NlZ6prT6PrWqX2ii+FrYx2Vq0MF03+jKS1yZ45LXYWmDQuVlYLtaMDF+G02rXXg34deDtO8e6hCtz4b/ALRubi2jsnuLJooNPEdmA0DIsey73/OjSn92d+DhvWbnwR4LvfES+I7zwhotzrSyJMNRl0+J7gOmAjeYV3ZXauDnIwMdKJvBHgu58O23hy48IaLNotrIZoNOk0+JreFzuJZYyu1T878gZ+Y+poA858I658QfHOqQXJ8WWmj203hfRdditbTS1dRcXK3G9JGkdmeEtEdyqUcr5YV4yrtJmR+N/GF78Om8RjxBLb3eheA9P8USJFbweXqd1NFcu6XAaMkR5tV4hMTASP8AN93b7BL4T8Kz6pqGqTeGdKlv9TtzaXt09nGZbuEqFMUr7cuhCqNrEjCgdqgXwR4Ljh0qGPwhoqxaNI02nINPiAsXZw7NCNv7slgGJXBJAPWgDMuf9E+N+l/Z/k/tXw/efbO/m/Zbm2+z9em37bc9MZ8znO1cdnWNpehfYtc1XXby6+16lqOyEyKnlpFbRNIYIVXJ+75sjMxJLPI5+VdkabNABRRRQAUUUUAFcZ8WP+SIePP+xfv/AP0meuzrjPix/wAkQ8ef9i/f/wDpM9AHGeD/ABT4sn1TSJdY8X2mtSXfijVfDl3ZWtnFBDarAt7KjYBaRZsW8WN0m3ypFyrP++aew1K9sfh2LXTL7ULe/wBR8Wa1bQR6XBbyXdwRqF9KUha5IgjIWJnLS5GxHVRvZCOs8EeCP+EYS4vNWk0rVNcmuLtxqlrpn2WVYbi5e6aDLSSMUE0jkDcBjbxkFjd07wn4Bn8IHS9J8M+H5fDWp7Ls2trZwmzu8hWWXYq7HyFQhsH7qnsKAPGb74jeNZ/APi7V28S/8I1eeFdHnmj+2W1q5u5/tuoWiLc4yhmxZRbfJZU86RvlkQrHXTeIfGWo+HbfxFcal43+wQ6b4402xgkvBaxK9nPHZSTWzFowCipcXDhhiQLGCXIVs9N4j+FPhXUvA+o+HvDeg+H/AA7c3Vvc28F5Fo8bfY/tEYhndFQxkO0Q25DDoudwXaenXw5pV1cW2qa3pOlahrkdvFBLqAsVVm8uRZQE3FmRBMokVS7bWAOSRmgDznQdT+IuueKp7261/T9M8PX2qapo8EYvIvOUW73MUb20DWmfPBtxIfMnlQqJT5YBVY+f8G6jqlt8JPAOg6H4t8QapqU2jw3Ullo8OmNeWyLa2p8vfcqkKQxi4iO1w07+fGwfarZ9mj0nwrZ+L5NUi0zSrfxLqFu2+6WGNby5hQxq2XxvdFPkg8kD5B6VSvPCfgH+w9N8Lah4Z8P/ANk/aD9h0uezh8jztskh8qIrt37fNY7RnG8+tAHn/g7xl4m8Sa14R1bVte+w2erW9swstOht5bKeWTTPtLW0u4tcwXIYvMDnyjDHEuS8hz7NXP6J4I8F+Gr577w54Q0XRruSMwtPYafFbyMhIJUsigkZVTjpkD0roKACiiigAooooAKKKKAOM03/AJLf4o/7F/SP/SnUq7OuM03/AJLf4o/7F/SP/SnUq7OgAooooAKKKKACiiigAooooAKKKKACiiigAooooAK4z4T/APJEPAf/AGL9h/6TJXZ1xnwn/wCSIeA/+xfsP/SZKAOzooooAKKKKACiiigAooooAKKKKACiiigAooooA4z4af8AIo33/Ywa3/6dbquzrjPhp/yKN9/2MGt/+nW6rs6ACiiigAooooAKKKKACiiigAooooAKKKKACiiigD8mvix/yW/x5/2MF/8A+lL0UfFj/kt/jz/sYL//ANKXooA/TL4T/wDJEPAf/Yv2H/pMldnXGfCf/kiHgP8A7F+w/wDSZK7OgAooooAKKKKACiiigAooooAKKKKACiiigAooooAK4z4sf8kQ8ef9i/f/APpM9dnXGfFj/kiHjz/sX7//ANJnoA5/RfE3jDxd4qv9PvvBkVz4JnvNQ0maSaKAxqkDywM7OblnmEjxFTEbZABL99hHmTn9F8U+LNJ+Fnwp8P8Ag7R/t9/qHheK8kk8iK48qKCG1Qjy5Lq2HJuF+bzSRtxsbduT01vAfhk6pc6itrdxzXHmtti1C4SKCSVWWSaGJZAkEzB5MyxqshMkh3ZdiYV+HXhWLw7pWg29vqFraaRG0NlJbardw3EERxmIXCSiUx/Kn7suV/dx8fIuADhT41+Jv2yTRLr/AIR/SfEt3qGnLY6XLp8tz5dpcRSSTF5UuVR3iEF4Mgpu+xNhf38WNqH4gakvxPsdAlltLyw1LULjTY0tNLuwls0UM0u837fuJ3/0dkeBFVo3dl3N5LFuzi8K+G4NU0/UrfRbSC5023FraGKMIsESqVRVUYX5FeRUOMossqrgSOGxbzwL4KXxPpusXLXdpf8A9oG6sYI9YuoIDd7JHdo7dZREXZPOZwE+cNKWzuckA8zXxZqsGuaZ8V9U0fSpvP8Ah/qmt2yWgaGcwq1jcJZzO27f5e84lGAxlc+UmPn7+OPVfEdx4k+Hni+8tLmaPT7W9j1PSLZrJofPknWNo0kkmKTRPa+Ysu7himFBTLXYPhZ8PoNUTUj4XtLm5it5rOI3Za5WC3lUK9vGshZY4doKrEoCIryKoUSOGLnwQtnod7pXhm6u7KbV8W19q11qVzdX0Fvtf/USys771LN5YLhI2laTDEFJADzO88XeMPGFv4I8QaVot20mj6PbeJtSEen3CRTyyxwtJHYsYnS4m+zPdwiJpFGbtCGLxEx+82l1He2MF5CsqxTxrKqzQvDIAwyAyOAyHnlWAIPBANQaX/ZS6XDb6J9kWwtM2kUdnt8qHymMZiULwuwoUKj7pUjjFU/C2iTeHfDFpo9xq13q00O9pLq7lkld2d2cgNIzvsUttQM7sEVQWYjcQDZooooAKKhmu7W2mtobi5ihlupDDAkjhTM4RnKqD947UdsDnCk9AamoAKKKKAOM03/kt/ij/sX9I/8ASnUq7OuM03/kt/ij/sX9I/8ASnUq7OgAooooAKKKKACiiigAooooAKKKKACiiigAooooAK4z4T/8kQ8B/wDYv2H/AKTJXZ1xnwn/AOSIeA/+xfsP/SZKAOzooooAKKKKACiiigAooooAKKKKACiiigAooooA4z4af8ijff8AYwa3/wCnW6rs64z4af8AIo33/Ywa3/6dbquzoAKKKKACiiigAooooAKKKKACiiigAooooAKKKKAPya+LH/Jb/Hn/AGMF/wD+lL0UfFj/AJLf48/7GC//APSl6KAP0y+E/wDyRDwH/wBi/Yf+kyV2dcZ8J/8AkiHgP/sX7D/0mSuzoAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACuM+LH/JEPHn/AGL9/wD+kz12dcZ8WP8AkiHjz/sX7/8A9JnoA8/0DxF8U7Gz0az/ALS8P6x/bfijV9K+1XdvcxPZeVLfvuC+bJ5qD7PlE3R7UjWLcd/mx9PceMfFVnql5JNLpU1ho2saboF7AlnIkt5NdLaZuIpPOIhRTeqfKZJCRER5nz5TZT4X+Cotcg1uHTruK/g1CTVElj1K6TE7s7MSBJgpmWYiMgoPPmwo82Tdp3Pg3w7eeIl164s5Wu/MSZ41uplt5pUx5csluGEUki7U2yOhZfLjwRsTABwGmeOPiTfQ6ZJcWPhq2l1jXNQ8PwQRtcSi2e3e7JumkO3zAq2jr5IRDIcN5sQYokGsahqviJ/hzrVtZaUviW08UalpCXc8beUnlW2o280qqCXCMbcS+Tv5KohkGPMHZ2fwx8IWH9l/ZodVH9l6hLqlrv1u+k2XMv8ArJDumO/dl8hsg+ZLx+8fdPbfDrwrZ+HW0G3t9QW0+2PqCSNqt21xDcPnzJI7gymWMtufdscbvMkzne+QDn7Lxj4q16XR9D0uXStO1af+1vtN9c2clzA39n3qWb7IFmjZfNaQSDMjbAuz587waP428VeMv7Nm8M2+labu8P6dr89tqKST/aPtnnFbdZUZPJ2/Z2BlMcufMB8v5MP01x4D8M3Gl2Oni1u7VLHzPJnstQuLW5/eNul3TxSLK/mOA77mO9wHbcwBo1DwF4T1L7Is+k+TDbW6WYtrSeW1gmt0zst5oomVJoVBYCKQMgDuAMOwIB5/ceIvH3iC38B3VpqWlaBfz+KNV0y7gW3mvLd/s8eoIgJEsJkQC3yQQu59jgJs2Hat/G3iqbVLO6ht9KuLDVtY1LQrLT3SSGWGa0W7xLLc7nDI5sm+VYAUEw5fy/n2U+F/gpdDg0STTru6sINQk1RYrvUrq4zPIrrKWMkjF0kEsoeNiUfzH3KdzZut4P0iw1S58QaTpvm6sPNuLa2uL+dbNLh1bdIsWXjgdyz7pUi3nzZCd29gwBzPw/8AG3irXf8AhFW8TW+lJ/wk/h9tbgj05JF+yeX9mDKzOx8zzPtSsAFXy9pTMv8ArK5K0+KPxau/DWmeJofAunjS9ak057WW/mS1jgS6uYIkiDRTXDzlln/1jRW4QIWMbEiKu5+F/wAPrfwT4Q0a3vdOtIdctNPjsZ3tLuW4txtCh3hWQKIvOKLJIERd78sXKhjPc/CXwNdwrDNYagIo5EkgSLWLyMWgRw6JAFlHkRhkjYRx7UzFEduYo9oBmWfjbxVH4u0vw1qFvpV1t8QS6JqGoQJJB5n/ABKvt8TRQFn2dQjFpW/1eQP3n7sh+IGpL8T7HQJZbS8sNS1C402NLTS7sJbNFDNLvN+37id/9HZHgRVaN3ZdzeSxbZ/4Vj4Q/wCEn/4STydV/tL+0P7U3/23feX9p2eX5nled5f+r/d4248v5Mbflqeb4deFZ/EVtrxt9Qiu7W8OoQxwardw28dwd26QW6SiIF98m/5Pn8yTdu3tkA6yiiigDjNN/wCS3+KP+xf0j/0p1KuzrjNN/wCS3+KP+xf0j/0p1KuzoAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACuM+E/wDyRDwH/wBi/Yf+kyV2dcZ8J/8AkiHgP/sX7D/0mSgDs6KKKACiiigAooooAKKKKACiiigAooooAKKKKAOM+Gn/ACKN9/2MGt/+nW6rs64z4af8ijff9jBrf/p1uq7OgAooooAKKKKACiiigAooooAKKKKACiiigAooooA/Jr4sf8lv8ef9jBf/APpS9FHxY/5Lf48/7GC//wDSl6KAPurwToPwK0/4VeCG8WaL4DtNUvNAsbqQ6nb2aTT7oFzIfMG5ssG+buQa7jSPAfwR8QWb3mg+DPA+q2yOYmmstOtJ0VwASpZVIzgg49xXmPjK0s1/YZ02/W1hW8k8N6JC04QeYyK9uVQt1IBZiB0G4+prvvinqGseGJfCNz4R1FNIl1vxRaWF+qWsLpdrMMM8m5CxcLEqhgwOOucLgA6D/hU/ws/6Jp4V/wDBNbf/ABFH/Cp/hZ/0TTwr/wCCa2/+IryLx9478Y+B7bXxZ/EyPWdV8NLZSXFpcaZbW8brPMQqS4+eSRkZcGLy1VUycscVv+J/GXi3SPjvZaNdeI3svC99fWVnaNp8FvdKk7AO9rdqymWJpgfkcMAFIODyQAd2nws+E8jyJH8OfCTtE2yQLo9sSjYBwfk4OCD9CKf/AMKn+Fn/AETTwr/4Jrb/AOIrwy18Xa94L+H/AMYfE1p4xmvNasfEl3BBa6iIHXaJrWD7QVVFclVYKAGEY+Ubau+JviJ470fwz8UrbT/HC39z4Qm0uSx1RLO2LTC6AEkcqhDGVBbI2hWyBkkZBAPZv+FT/Cz/AKJp4V/8E1t/8RR/wqf4Wf8ARNPCv/gmtv8A4iuK8QTfEDSPiz4L8N/8LEuns/EsuotMqabaD7NHDbq6LGTGTkMzfMxPAUEHBLeb6f8AGDx/rPhqzlm8XWmj3Ft4PvvEDzCzhLX1xDdywpGwcbQpWMEhApyTgjgAA99/4VP8LP8AomnhX/wTW3/xFVNS+HPwa0fTpdS1fwJ4M0+yhx5lxdaXaxRpkhRlmUAZJA+pFeYW3xJ8bXHjrwjJq/iEafoOvppIh/sq3t7mKO6lhSWW0ukYGaIy7j5bhgFUg4bkjR+M3ijXH8SeIfBNv4gt9H0mPwRe6xIphjd7yTc8XlFn6Lt5+TDZ70AeiWvww+Ed7Zw3ln8PPCFzbTossU0Wk2rpIjDKsrBMEEEEEdaqReA/gjca7caDB4M8Dy6tbIJZrFNOtGniQ7cM0YXcB8y8kfxD1FeTP4w+IFrZeB/B/g65ktQfAVvqsBhitCZrlVVAsrXTqohUAFvL+cZz06dh4bvL/UP2kdH1DVUgj1C5+HkM1yts4eJZWuwXCMGYFck4IYgjuetAHc/8Kn+Fn/RNPCv/AIJrb/4iqtn8N/g5qH2j+z/AXgy7+zTNbz+Rpdq/lSr96NsL8rDIyDyM1xfifxl4t0j472WjXXiN7LwvfX1lZ2jafBb3SpOwDva3aspliaYH5HDABSDg8kc/a+IvHVl4B8Xt4a1C3l1ay8dXNidsNna3eoW8aqXWIeUIpLpgC2ShLYbg4AoA9bf4WfCeN40k+HPhJGlbZGG0e2BdsE4HycnAJ+gNP/4VP8LP+iaeFf8AwTW3/wARXjEniG68R678F9bb4karHp+oJrFxJfy21rZmNo43AZ43jaMOqu0RJBUhSVCliTnaT8SPjBrPg0+Kv7WNpaT2erS3JaHT0W0mtlkkhS2Qu0z8xbZBKhIViRjhwAe8f8Kn+Fn/AETTwr/4Jrb/AOIo/wCFT/Cz/omnhX/wTW3/AMRXjP8Awm/xN+yGH/hNx5n/AAgUfjETf2Zb7hOqkNBjbjymJDHjcCOGA4pNJ+L3ijUbjwhrdn4wtdRi1XX7HR9Q0wWUUMEBngV5I4hlp2aMk5kZwpJACkA0Aeu/8K3+Dn9q/wBk/wDCBeDP7R8n7R9k/su183yt23zNm3O3dxnGM8Va/wCFT/Cz/omnhX/wTW3/AMRXnfjvWdd0n4ueLRpmrm1e18BTavazLZWrS28kU/EayNEWMTbCSjFhl2Iwdu3Ft/HXj9LK5huPF00003w5TxWk62Vspgu1IO1B5ZBRgMMGDHk7SvGAD17/AIVP8LP+iaeFf/BNbf8AxFH/AAqf4Wf9E08K/wDgmtv/AIivGf8AhN/ib9kMP/CbjzP+ECj8Yib+zLfcJ1UhoMbceUxIY8bgRwwHFXdQ+I3jEz3l0fFDadDcfDhPFMcaW9v5dte7k4QvGxKNtI2uWP7xsEHbtAPWf+FT/Cz/AKJp4V/8E1t/8RR/wqf4Wf8ARNPCv/gmtv8A4ivHrjxv8QZZlaDxpcW8Z+G6eKmQWVq3+mKqg7SYuEYqSQc/ebG35dsviD4n+MpY9OW28UWmgFPh8PFjsLWJzd3fH7o+ZkCP2XDc9aAPTIvAfwRuNduNBg8GeB5dWtkEs1imnWjTxIduGaMLuA+ZeSP4h6ip7f4b/B28uLq2tPAXg24ntHEdxHFpdqzQsRkK4C5U4IOD2NeWf8JZqf8AwsT/AITry7f+0/8AhU39rbNp8rzvN83GM527u2c471kaf8SPH2m6beWuh6xp/iC+1Hwhb+Jo0jsoI2t72e5SORVEWA5xIzBXDMzhRls4IB7TefDf4Oaf9n/tDwF4MtPtMy28Hn6Xap5srfdjXK/MxwcAcnFWv+FT/Cz/AKJp4V/8E1t/8RXjOp6x8QE8TaHearq2pXnh6TxfpNhpo1zRbSCSZXRmnk8trdZI3VhtSQbeGbGTyOgt/iB4qup/iLr7eLbOz/4Ra+1OytvDstnHtulgtTJC+8kS7iQXOCQVUgAdQAejf8Kn+Fn/AETTwr/4Jrb/AOIo/wCFT/Cz/omnhX/wTW3/AMRXAfCvx14o1fx7puhax4nt/EFrqfhG38ROy28Ub2lw8oRolMWBsw3RgW4HNe5UAcZ/wqf4Wf8ARNPCv/gmtv8A4ij/AIVP8LP+iaeFf/BNbf8AxFdnRQBxn/Cp/hZ/0TTwr/4Jrb/4ij/hU/ws/wCiaeFf/BNbf/EV2dFAHGf8Kn+Fn/RNPCv/AIJrb/4ij/hU/wALP+iaeFf/AATW3/xFdnRQBxn/AAqf4Wf9E08K/wDgmtv/AIij/hU/ws/6Jp4V/wDBNbf/ABFdnRQBxn/Cp/hZ/wBE08K/+Ca2/wDiKP8AhU/ws/6Jp4V/8E1t/wDEV2dFAHGf8Kn+Fn/RNPCv/gmtv/iKP+FT/Cz/AKJp4V/8E1t/8RXZ0UAcZ/wqf4Wf9E08K/8Agmtv/iKP+FT/AAs/6Jp4V/8ABNbf/EV2dFAHGf8ACp/hZ/0TTwr/AOCa2/8AiKP+FT/Cz/omnhX/AME1t/8AEV2dFAHGf8Kn+Fn/AETTwr/4Jrb/AOIo/wCFT/Cz/omnhX/wTW3/AMRXZ0UAcZ/wqf4Wf9E08K/+Ca2/+Io/4VP8LP8AomnhX/wTW3/xFdnRQBxn/Cp/hZ/0TTwr/wCCa2/+Io/4VP8ACz/omnhX/wAE1t/8RXZ0UAcZ/wAKn+Fn/RNPCv8A4Jrb/wCIo/4VP8LP+iaeFf8AwTW3/wARXZ0UAcZ/wqf4Wf8ARNPCv/gmtv8A4ij/AIVP8LP+iaeFf/BNbf8AxFdnRQBxn/Cp/hZ/0TTwr/4Jrb/4ij/hU/ws/wCiaeFf/BNbf/EV2dFAHGf8Kn+Fn/RNPCv/AIJrb/4ij/hU/wALP+iaeFf/AATW3/xFdnRQBxn/AAqf4Wf9E08K/wDgmtv/AIij/hU/ws/6Jp4V/wDBNbf/ABFdnRQBxn/Cp/hZ/wBE08K/+Ca2/wDiKP8AhU/ws/6Jp4V/8E1t/wDEV2dFAHGf8Kn+Fn/RNPCv/gmtv/iKP+FT/Cz/AKJp4V/8E1t/8RXZ0UAcZ/wqf4Wf9E08K/8Agmtv/iKP+FT/AAs/6Jp4V/8ABNbf/EV2dFAHGf8ACp/hZ/0TTwr/AOCa2/8AiKP+FT/Cz/omnhX/AME1t/8AEV2dFAHGf8Kn+Fn/AETTwr/4Jrb/AOIo/wCFT/Cz/omnhX/wTW3/AMRXZ0UAcZ/wqf4Wf9E08K/+Ca2/+Io/4VP8LP8AomnhX/wTW3/xFdnRQBxn/Cp/hZ/0TTwr/wCCa2/+Io/4VP8ACz/omnhX/wAE1t/8RXZ0UAcZ/wAKn+Fn/RNPCv8A4Jrb/wCIo/4VP8LP+iaeFf8AwTW3/wARXZ0UAcZ/wqf4Wf8ARNPCv/gmtv8A4ij/AIVP8LP+iaeFf/BNbf8AxFdnRQB+SnxNtLWw+MPjSxsbWK1tLbXL2GGCFAkcSLcOFVVHAAAAAHAFFTfFj/kt/jz/ALGC/wD/AEpeigD718E6hJq/wS8EaXrHwZ1fxFY2+j2LRNP/AGVLDIVt1USost0CMgnGVVsNyByK6K/e11WzsrPVP2f9UvrawTyrSG5i0aRLZMAbY1a7IQYVRgY+6PStv4T/APJEPAf/AGL9h/6TJXZ0AebaleLrUrTax8BtY1GRo/JZ7tdGlJTO7aS14eMgHHTNItzGt/BqC/ATV1vLdg0NwE0bzIiEVAVb7ZkEIirx2UDoBXpVFAHnS6lIk9/cJ8C9bWbUhtvZB/Y4a6GMYkP2z5+PXNUTFpraOujN+zxqB0xZvtAszBovkiTBG/Z9r27sEjOM4Jr1OigDzGR7Wa8sLyX9n/VJLnTUjispmi0YvapGcxrG32vKBTyAMY7VXWz0dbSO0X9nK9FvFKZ44hbaJsSQgAuB9rwGIVRnrwPSvVqKAPOHvjJqserSfAjWX1GOTzUu2GjmVX2hNwf7ZkHaqrnPRQOgpdV1GTXfK/tz4F63qnlBhH9s/sebYGGGxuvDjI4PrXo1FAHl8n2KXTbPTZf2fNSksbFme1tmh0Ux27McsUX7XhSTySMZNT/bB/wkX/CR/wDCh9Y/tr/oI7dH+0fc2f6z7Zu+78vXpx0r0migDziS/abV01ib4E61JqSSect240czK+0JuD/bMg7VVc5zhQOgqjb22lWkEtva/s631vDKwaSOK30RVchXQEgXfJ2ySL9HYdCa9VooA83e8ElpYWcnwH1h7bTmD2cLLo5S1YdDGPtmEI9Riq832K5lv5rj9nzUppNRx9seSHRWN1hgw8wm7+f5lU855APavUKKAPLEg0yPyfL/AGd79PIge1i2waKPLiffvjX/AEvhW8yTKjg72z1NZ+p3Hhjw94evdV1D9nm9tNL02Fr2dltNGIiSJWcvtW6JJUbiMAnk4617HXGfFj/kiHjz/sX7/wD9JnoA5/UoNM1jUZdS1f8AZ3v9QvZseZcXUGiyyPgBRlmuyTgAD6AVDLp+h3EVvFP+zfdyx2yGKFXtdEYRIWZyqg3fA3MzYHdie5rM1j4na/o/iXxfp83i7webvQ7zZYeHHs3TUdXQ20NxHDEftefMcy+SrLC4LrkIc7B6ZrfjLw74evks9VvJY5TGJpWitZpo7SIkgS3Dxoy28Z2v+8lKLiNznCNgA4xINMj8ny/2d79PIge1i2waKPLiffvjX/S+FbzJMqODvbPU0klvpc1ra2k37Ot/Jb2iulvE1vopSFXJLhB9rwoYkkgdSTmu0ufGXh2z8RLoNxeSrd+YkLyLazNbwyvjy4pLgIYo5G3JtjdwzeZHgHemS28ZeHbzxE2g295K135jwpI1rMtvNKmfMijuCgikkXa+6NHLL5cmQNj4AOGt9P0O0laW1/Zvu7eRkeItFa6IpKOpR1yLvoysykdwSD1qxIthLYWeny/s9ajJZ2LM1rbtDopjtyx3Eov2vCkk5OMc1sah8TPBP/CO6xeTeKJdGtLWze4/tKS0khDRcKJ7Vpoyl0Azx7WjEqkyRDDeYoa7qXjKytfGun6BHeRRx+Z5d9O9rcSRxyuq+RbmZU8iGRzIjYkkDEGNVjYzqygGD9qT+3/+Eg/4ULq/9sYx/aG3RvtGNmz/AFn2zd9z5evTjpWB4i0ZNY8F6v4a0v4I6xokeqNG1xJbRaOolKSLJ86peqWztxncGGSQQcGu90H4keCfE99HaeH9fi1EyySwxzwxyG3kljLb4lm2+W0m1GcRhtxjHmAFCGrT13xPpHh37OuovdyTXO4xW1jYz3s7quNziKBHfYpZAXxtBdASCyggHgfhH4Yaf4f1iXUtT+COo6nmBoEtRFp5gGWVi5S51Sc7/lABUrwSMHPHqSavcx6zNrUfwP11dTnQRy3inRxNIgAAVn+2biMAcE9qfa+MvI8ceJZ9Q160uvC8Wj6VqGmm0h35+0SXUfyshZrh5WijCBB825FVSxJcs/il4Zs9D0ubxRrtpZatqNxLbJp6WtxHOJlXzfs4gkQTs4jaMAtGhlMkRVF86NCAQ6VqD6CZ20P4Fa1pZuG3TGzGjw+afVtt4Mn61p/8Jl4i/wCiT+Kv/AnSv/k2jU/id4Q0jy/tk2qnd5Ct5GiX0/kyTbfKhl8uFvKmbzI8RPtk/eJ8vzLktfiB4TXQLXVLbXrvX7a/uLoWslhYy3ssqxzskhSO2iLNDG2IxLtK4MeXYuGYAP8AhMvEX/RJ/FX/AIE6V/8AJtH/AAmXiL/ok/ir/wACdK/+Tau6h498J6b9kafVvOhubdLwXNpBLdQQ2752XE0sSskMLAMRLIVQhHIOEYjpqAPP4/iNqk2uXWiR/C7xU1/aW8N1NF52mfJFK0ixtn7Zg5MMowDkbecZGbv/AAmXiL/ok/ir/wACdK/+TaNN/wCS3+KP+xf0j/0p1KuzoA4z/hMvEX/RJ/FX/gTpX/ybR/wmXiL/AKJP4q/8CdK/+Ta7OigDjP8AhMvEX/RJ/FX/AIE6V/8AJtH/AAmXiL/ok/ir/wACdK/+Ta7OigDjP+Ey8Rf9En8Vf+BOlf8AybR/wmXiL/ok/ir/AMCdK/8Ak2uzooA4z/hMvEX/AESfxV/4E6V/8m0f8Jl4i/6JP4q/8CdK/wDk2uzooA4z/hMvEX/RJ/FX/gTpX/ybR/wmXiL/AKJP4q/8CdK/+Ta7OigDjP8AhMvEX/RJ/FX/AIE6V/8AJtH/AAmXiL/ok/ir/wACdK/+Ta7OigDjP+Ey8Rf9En8Vf+BOlf8AybR/wmXiL/ok/ir/AMCdK/8Ak2uzooA4z/hMvEX/AESfxV/4E6V/8m1S0n4japrmh2Gt6X8LvFVxYahbx3VtL52mL5kTqGRsNeAjIIOCAa9ArwDRfGeq+GfA/wAKdL/4THwr4X0nUvB8Vx9q160Z/wB9BHarsV/tUKnctxkDGR5THnd8oB6Z/wAJl4i/6JP4q/8AAnSv/k2j/hMvEX/RJ/FX/gTpX/ybRo/ji3/4QSy8QeIDte4uJrWD7BbSznUdksipNbQxh5HSWOPz1Vd+Izu3MqlzPN8R/B8ENtM+pytFNGZpHjsp5BZIHZGa6KofsgVkkVjP5YUxSg4Mb7QCD/hMvEX/AESfxV/4E6V/8m0f8Jl4i/6JP4q/8CdK/wDk2tO28ZeHbzxE2g295K135jwpI1rMtvNKmfMijuCgikkXa+6NHLL5cmQNj4xrj4meCbhrS1HiiXTJby8tobGR7SSIamXmRVW1aWPbcxvuVWkh3BUkD7kBV6AJv+Ey8Rf9En8Vf+BOlf8AybR/wmXiL/ok/ir/AMCdK/8Ak2tO58ZeHbPxEug3F5Kt35iQvItrM1vDK+PLikuAhijkbcm2N3DN5keAd6Zp6D8SPBPie+jtPD+vxaiZZJYY54Y5DbySxlt8SzbfLaTajOIw24xjzAChDUAQf8Jl4i/6JP4q/wDAnSv/AJNo/wCEy8Rf9En8Vf8AgTpX/wAm1d0/x74T1L7W0GreTDbW73hubuCW1gmt0xvuIZZVVJoVBUmWMsgDoScOpN3w94n0jxRb3k2kPd/6FcfZbiK8sZ7OWKXy0k2tHMiOPkkRgcYIYUAYv/CZeIv+iT+Kv/AnSv8A5No/4TLxF/0SfxV/4E6V/wDJtdnRQBxn/CZeIv8Aok/ir/wJ0r/5No/4TLxF/wBEn8Vf+BOlf/JtdnRQBxn/AAmXiL/ok/ir/wACdK/+TaP+Ey8Rf9En8Vf+BOlf/JtdnRQB5/pnxG1TWLOS7074XeKp4Y7ie1ZvO0xcSwytDKuDeA8PG4z0OMjIINXf+Ey8Rf8ARJ/FX/gTpX/ybR8NP+RRvv8AsYNb/wDTrdV2dAHGf8Jl4i/6JP4q/wDAnSv/AJNo/wCEy8Rf9En8Vf8AgTpX/wAm12dFAHGf8Jl4i/6JP4q/8CdK/wDk2j/hMvEX/RJ/FX/gTpX/AMm12dFAHGf8Jl4i/wCiT+Kv/AnSv/k2j/hMvEX/AESfxV/4E6V/8m12dFAHGf8ACZeIv+iT+Kv/AAJ0r/5No/4TLxF/0SfxV/4E6V/8m12dFAHGf8Jl4i/6JP4q/wDAnSv/AJNo/wCEy8Rf9En8Vf8AgTpX/wAm12dFAHGf8Jl4i/6JP4q/8CdK/wDk2j/hMvEX/RJ/FX/gTpX/AMm12dFAHGf8Jl4i/wCiT+Kv/AnSv/k2j/hMvEX/AESfxV/4E6V/8m12dFAH5KfE2aS5+MPjS4mtJbOWXXL12t5ihkhJuHJRijMuR0O1iMjgkc0VN8WP+S3+PP8AsYL/AP8ASl6KAP0y+E//ACRDwH/2L9h/6TJXZ1xnwn/5Ih4D/wCxfsP/AEmSuzoAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACuM+LH/ACRDx5/2L9//AOkz12dcZ8WP+SIePP8AsX7/AP8ASZ6AMaTwd4quX8bXTRaVaX91rEWt+H7mK8kkMc0NtDAiz/uVMaOLcLIIyxaO4ljB/ialrnw/1XxJ4kXxJrfgvwVqt/eafDp0sWqu17FpXlTTsJod1uDcbxOC0Z8jmILvO7cvTaz4z+y+PvDnhnSbjSrz7VqD2erx/at11Y5sp7mAeUv3d/kE7nI4HCtu3JtQeLPCt1/a/wBm8TaVN/Ym7+0/LvI2+wbd27zsN+6xsfO7GNrehoA8/wDHXgnxtrfiQahpb2mowxahYX9ot5r95YRWyW80MrW7WsUUkM+5onYTSfOpmAxiJM9N4Z0fxVoOoT6Tt0ptAOoX2o/bPOka6m+0zyz+T5OwJFtebHmeZJuEX3FMmY9Ofxv4LtYbua58X6LBFZSSQ3LyahEogeN40kVyW+Uq00SsDggyIDywzp2+raVeapfaXaanaXF/p/l/a7WKZWltt67k8xAcpuHIyBkcigDzOXwd4+/4UxqHw3hi8P8Akw+HzoFlcveTbrzMQgFxL+5xb7UDN5SibczBfMQLue7ceDvFV5ql5HNFpUNhrOsabr97Ol5I8tnNaraZt4o/JAmRjZKPNZ4yBKT5fyYfZ1P4peAdN8MR+Jf+Er0q80l9Qg0z7VaX0MkazSuq4L7wvyK/mOM5Eas2DiodS+KHgvQbnTzq/jHRTaaxeeRZTR3USR26CzW43Su0uCCCpDgAYuYBt+YOwBz+leE/H1t/wi32zTvD6/2b4o1HW7rytVmf9zdfasKmbUbnX7bJwdoPkryPMPl9N460HxDrX9nto8vn20HmCfT/AO2brR/NdtuyX7TbK0nyBZF8rGxvN3E5jXOnceKtA0XRv7T8R+LNFtbRrya1W8luEtod6ySAQ5dyDIgRlbnJaNztX7o6CgDwbS/hX40m8NHQfEen+GpbSDQ9D01Y0v5bmO9fTLlpwkqPbKEjnDsjH5ygGdsmcDprXwVr9hc+EpNI8KeD9CtNP1yTVL2x0uZ4I4kazktfkK24FxIRM0hYrCAESPnmStrWvH1rJ4asNc8EaloviG0fXNP0u7uIb0TRwpPcxRPt8rIaQCZcKWUANuOcBW2b/wAVafZ+NdI8Ji70/wDtG/jkuGgmv4opliVWwUhJMkpZlOMKFCxyksCqq4B5B4v1aHR/ifrS3V3aGwGoWmpSeH5dTjs7vWJ4obdopbW3aCSW7ffDEieXPAjyweUU+WR5em0Lwn4+0WWy1z+zvD8+rWtxrK/Yf7VmWBodQvY7zf5/2UsHjaPy9nl4YHfuXGyu5PjfwWLG8vj4v0UWljHBNdTnUIvLt0nAMDO27CiQEFCcBgRjNGk+KtA8RX0D+HPFmi6taGOcNFZXCXEjuhiyyujkAIJFDDaTmaM5XowBw3xM8CeNvGGh3OnWt/aX32zR2sGX+1rzR4La5ZXWS48qAS/aUfcn7mZiEEWAW81zXc+FdW1/V7G+k8Q+H4tFnt7yS2iWG6eeO4RAoMqmSKJwN+9RlAGCblLIysZ4PFnhW6/tf7N4m0qb+xN39p+XeRt9g27t3nYb91jY+d2MbW9DVzS9W0rXNLh1TRNTtNTsJ8+VdWcyzRSYYqdrqSDggg4PUEUAczpv/Jb/ABR/2L+kf+lOpV2dcZpv/Jb/ABR/2L+kf+lOpV2dABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAV4z4B8Parq3hv4XahNpulXnhqPwONMvUurhjLL9phtWI8nyijpi2VSGcZErcfJh/Zq85+HPiHQNG+D3wzsdX1zT9Ou9S0OwhsoLq5SKS6f7PENsasQXOWUYGTlh6igDM1DwL4q1rw3pOjeJNL8P8AiOHw1qAnsU1S+knGswiG4t0N4Xt2EcypLHIzKJQ8iNgRggrmeLvhh4s1fwVL4e0e10WytLnS57OPS9O1S70ey0uaVpSzhLeMi9BEkYZZVRSYWYKvnuq+st4h0BNZi0V9c09dUmkeGOyNygmd0jWV1CZ3ErG6ORjIV1J4INEPiHQLnxFc+HLfXNPm1q1jE0+nR3KNcQodpDNGDuUfOnJGPmHqKAOZ8H6T400Nv7NvrbRYtLe8vNSmuIbuWeZ3uZpbhoFjMUaoEkmIEpZi6xf6tDJ+75mTwh8Sbf4faD4NsbTw1NaeH5NMSGabUbhJL5LOeGVZWxbkQFhbhTGPNGZs+YPKxLN4Z+Iuq+MdcnvPDnijwVd6SlxfWcek+cxvZJomlS2HnpIyhJlgln3eSSsa4VZOZBs6T8RIZfA/w/1LVp9Kt9Y8W29nItvNfR2iFpY0eUxrIxeTBcKqIHYu8akqpZ1AIdT8Ga/deItTgt2086Lq+uafr093JO63Fs9r9kxAsAjKyB/sSfvDKhXzT8rbBvzNK8J+Prb/AIRb7Zp3h9f7N8Uajrd15WqzP+5uvtWFTNqNzr9tk4O0HyV5HmHy/RpvEOgW3iK28OXGuafDrV1GZoNOkuUW4mQbiWWMncw+R+QMfKfQ1z/hz4i+FfGnkyeGfFGlS+XqE1nPbGaOWabZ56qIwkny7/IaZGIbdEjHaM7lAOT8K/C+68LeFb7SLHwd4Fhu4dDk0mG/NqZJNafYqq95iJDHG5QNJEDMWL/fGzL9z4K0jW9G0Oa21u53u9w0lva/b5tQ+xxbVHl/apwss+XDybnAK+ZsHyopOnpviHQNZvtQsdI1zT9Ru9Nk8m9gtblJZLV8sNsiqSUOVYYODlT6GodP8WeFdW0O713S/E2lX+k2e/7TfW15HJBBsUO++RWKrhSGOTwDmgDZoqlperaVrmlw6pomp2mp2E+fKurOZZopMMVO11JBwQQcHqCKzIPG/gu6htJrbxfos8V7JHDbPHqETCd5HkSNUIb5izQyqoGSTG4HKnAB0FFY0vizwrBpeoapN4m0qKw0y4Npe3T3kYitJgwUxSvuwjgso2sQcsB3rTtLu1v7GC+sbmK6tLmNZoZ4XDxyowyrKw4IIIII4IoAmooooA4z4af8ijff9jBrf/p1uq7OuM+Gn/Io33/Ywa3/AOnW6rs6ACiiigAooooAKKKKACiiigAooooAKKKKACiiigD8mvix/wAlv8ef9jBf/wDpS9FHxY/5Lf48/wCxgv8A/wBKXooA/TL4T/8AJEPAf/Yv2H/pMldnXGfCf/kiHgP/ALF+w/8ASZK7OgAooooAKKKKACiiigAooooAKKKKACiiigAooooAK4z4sf8AJEPHn/Yv3/8A6TPXZ1xnxY/5Ih48/wCxfv8A/wBJnoA4yPwt4stvF/hVYPCFpcR6J4o1TUptZnvIox9kvjePtgADSHAnjDqwTMkcYG5Myx8yfhffxfCDVPDbfD/VdT1y18LvoUVxf66t1BcXDCJQ9nDNcNHFCJIUm3MIHQRRBEJyqe8w+IdAufEVz4ct9c0+bWrWMTT6dHco1xCh2kM0YO5R86ckY+Yeoo0vxDoGtzTQ6Lrmn6lLBHFNKlpcpMY0lTfEzBScB1+ZSeGHIyKAPP7rQzB8UfCXibT/AIXy/Z9K8N3dqrwpYJJZSN5LQWq5mGCqxzxjZmNTcYDbWkK8z4c8J+KtP8O+CtDt/h7FaNYeC9Q0e6XUWtHsFvpvs5xOkUzPJHI9q7OUViROueS+z023+IHgvWm+y+HPH3hq6u1khLLFfRXJ2NNHGV2pICC5dY1OcB5E4b7p2YfEOgXPiK58OW+uafNrVrGJp9OjuUa4hQ7SGaMHco+dOSMfMPUUAeJvofxAuNV1zULjw34q1Tzf7AmgfV59HSeT7DqjXE0Ki2lSMfu5NylsZKuCw+QG5Z6F41tPE0+qWnw5+ySDxgdZ8mO+tVtpRLo72ckwdW37PtPzsxiEhSUOI2fcg9g03xDoGs32oWOka5p+o3emyeTewWtykslq+WG2RVJKHKsMHByp9DXM6L4+tdW8VeJANS0WTwrpul2epWurWt6JY5Eke6Sd5JOEQI1qRgEgBSS3O1ADzm08K+KIPCljpemfDe70q5S41yC3SWbTms4LW6vBPFbXUHmOrWcisgk8n98n2ZlQYcFvbPENpdX/AIV1axsbXT7q7ubOaGGDU0L2srshCrMo5MZJAYDkrmoU8WeFZNDg12PxNpT6TceZ5N8t5GYJfLV3k2ybtp2rFKzYPAjcn7pxNaeIdAv76Cxsdc0+6u7mzXUYYIblHkltWOFnVQcmMkgBx8pPegDwy50n4iPrep3kvg/xhra3cmgPHPqdxoscyCx1GS6mTFvNGmCjjZwSWLAkDBroPEHgT7V4z8SXGreB9V8V2Wrahb6lHFFrXkacY4be3Typ7Zp0SWbfbMVDRNG26JXkRdxj9T03xDoGs32oWOka5p+o3emyeTewWtykslq+WG2RVJKHKsMHByp9DUOo+LPCuj6oNL1bxNpWn35t3uxa3V5HFKYVVmaXYzA7AI3JbGAEY9jQB5LBpWr+Fvg38LNLsvD/APZfinSriOGDTdkEvmXYsblJ22JMkUu9DPL81xD13li48mSfwNYTp8TtMvbfwnqEdxY2eq2Ov6hOtnGbe8u7mDUFiISd2MY3u6BDKEFzGpYt5pX1P/ilfHPhj/mFeJtAvf8ArneWs+x/+BI21198FfUVc0vSdK0PS4dL0TTLTTLCDPlWtnCsMUeWLHaigAZJJOB1JNAHlum6H4qt/htpPhn/AIQmJNU8M6Xa2CapdPaSvOYpLfzGsFJcZItzJGbjygJUti6Eb/LPh/qeveH/ABhqeh+JPD3iVrjxPqj31rqGovpryeVFYW8bNOlpL8gDQ7Ayx7cyQhm3Pz6/RQBxmm/8lv8AFH/Yv6R/6U6lXZ1xmm/8lv8AFH/Yv6R/6U6lXZ0AFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABXzbP4f8Z6z8AtAs/DWn6hNFq3gOz09W0caekk8ptXHl3r3eG8geauzyDuBe4JwSlfSVec/CvVLW1+E3guG81nT4ok8N6MBbOwSaN5Y/LRmYvyJGCog2glkcAsThQDjG8P69HD4v1HTfhPqFhd6x4s0jWFjjk01JpreB7WWUsy3O3Ikt7hsFuWuQf4pCunNo3jeP4n+H7htD1WbSdP8QXV68dj/AGZFpcUM0N1Gs6Ast203+kI827ILmcoG/d59N/4Szwr/AMIx/wAJT/wk2lf2B/0FPtkf2X7/AJf+t3bPv/L168da5/UvH1rpfjLSUvNS0W28H3+h3GqDWJb0AM6T2safMcRrGVuVIbcxcsANu35wDz+ysfFsF94Xvp/hLrT3ejeJNX1VpxcaWZBa3hvSI0Y3eck3FuXXhcxnk7Vzmap4R+I0nwYsfDdp4c1WzvZfB8WhTQaY+l+bLcRRSxFLyWdzm2O5Wi8ht4Ek5baxUD2zUvG/gvRpruHWPF+i6dLZyRw3KXWoRRGB5ELxq4ZhtLKrMoPJCkjgUN438Fxw6rNJ4v0VYtGkWHUXOoRAWLs5RVmO792SwKgNgkgjrQBzOnWuuQeJdYW78Dy3lp4i1S01hZrqe28nTgltaxlJgHZzPG9qzr5SSIW8r94vzMnM2WgeKrfxV4XkuPAEskWkeLNXvRqiXVo0iWt2978wUyBljP2m1bAJcmKTcilI/M9TvPFnhXT9Lg1S/wDE2lWlhcW4u4bqe8jSKSHci+arlsFMyxDcDjMiD+IZ2aAPLPDeh+Iovh1beEbrwTp66jonhttFi1DWXhmtb2Xyo49qJEXkNrI0QaTzBE20RjYxJ8vmYtF8bT6n4nvNU8KeMNYW8s9IFpNqN5o0F1HNa30spaP7O4izH5yzIJFKu0To5wVB9A8R+PrW3tlHhPUtF1i7tNc0/S9VhF6JJLBLi8S3bKR5IkyxAVyoBDHnZsboP+Es8K/8Ix/wlP8Awk2lf2B/0FPtkf2X7/l/63ds+/8AL168daAOYl8M69rHwN1zwtdQ2llrGr6fqFuu9UjAe483Y9x5IKecRIrTGMFDIZCmVIrjJ9O1jxB488Z3UHhL+x79rfwzqpsZJoDdXa2uo3MreYUYxCZktzGgMjLgRbnTJVPWtQ8WeFdJ0O013VPE2lWGk3mz7NfXN5HHBPvUumyRmCtlQWGDyBmuSTUtA0P4s+MNT17S/DWgxWel6dOfED7IridJ5JoitxOwXaN1tGqplh8qndkhUAOSvPCnjLWdS1TWtY8J3dvZf8JRFrcNjpetiHUbiE6R9i2rIjxJG6uYyw88A4mUF1CGb1PwbpUei+ErWxi0mXSVMk1wbSe+e9mQyzPKTLMzMWkYuWf5nAZmAZwAx2rS7tb+xgvrG5iurS5jWaGeFw8cqMMqysOCCCCCOCKmoAKKKKAOM+Gn/Io33/Ywa3/6dbquzrjPhp/yKN9/2MGt/wDp1uq7OgAooooAKKKKACiiigAooooAKKKKACiiigAooooA/Jr4sf8AJb/Hn/YwX/8A6UvRR8WP+S3+PP8AsYL/AP8ASl6KAP0y+E//ACRDwH/2L9h/6TJXZ1xnwn/5Ih4D/wCxfsP/AEmSuzoAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACuM+LH/ACRDx5/2L9//AOkz12dcZ8WP+SIePP8AsX7/AP8ASZ6APP8AXNB8Yt4z05rvwfquu6HZ6xe3U+mWK6SmlzW89vdxBkWV453mb7SpmEp2M7zkZGysZfDWo6L8NNB0vXPBd3ouj6X8P9W0vWblbi1jitppUgaRyYmlc7jayuXSKU5mQlWbeq/Rlc/N4jkh+Ith4ROlS+VeaXc6kuoGRPLzDLBGYggJYn9+GJIUAbQNxLbADxnVoPEmranFL4h8FahqHjOe80q+s7eO2sLWNbPTr4SyyxZvpwsii6eMkyqWFxGqrtErDs9J8O+IofEWiaXcaLLDaaN4k1TXn1RpoTb3MV19u8uKNQ5l8wfbU3b41X93Jhj8m/utC8J+FfC/2j/hGfDOlaJ9p2+f/Z1nHb+btzt3bFG7G5sZ6ZPrWzQB4NoXwu1Bfh1qHhU+H9Qstaj8J3Hh1dW1bXpbm1llkiSMm1hEsvlwM0QYkpCyqsYEZywSbWfCfizxN4h8V6t/wg/9iWGq2+iTsq6nFFqN3LY37zSJmBtqTND8qP54C4g+cZcQ+50UAeJnwSp13wXqcPww1BhB4kk1O6m1TU4dRu7ZPsX2cSzSTzuQfMFu4SJ5QEtkbhwsYNA0TxJZzeGJj8O9QsJR401XWtRfzrAFYbhLtIppClwd5C3cKnG5gIHGCBHv9A0PxnJq/gaXxLL4d1CCeO8urIaXFsuLgyQ3clsFyp2AsyAk7vLTJJfYpeusoA8Z8HaN43sfiXoNzrWh6qthY6PeaZIy/wBmR6ZYyO9q6izSFln+zH7MyqJVaQDysgfOR03xKt7+H+xNY8P6j/Z/iFrg6NayLCs7vFebUkKxtw3klIrtuCSlm6kqjOw7q7a6Sxnexhinu1jYwxTSmKN3x8qs4VioJwCQrEDnB6VB/ZOlf25/bv8AZlp/a32f7J9u8lfP8ndv8rzMbtm75tucZ5oANJ0uw0PQ7DRNLg+z2Gn28drbRbmby4kUKi5YknAAGSSau0UUAFFFFAHGab/yW/xR/wBi/pH/AKU6lXZ1xmm/8lv8Uf8AYv6R/wClOpV2dABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAV8p6V4O1DV/BWgzQ/CiXXrC+0PwjM1yP7O8u4ezYyXDFZp1YlraXyAWXLAMhwmCfqyuM+E//ACRDwH/2L9h/6TJQBybaT4qXxpqviBfB+oPBY+LF1iCEXFp5moW50g6eTDmbaCJB5hEpj/dkYy+UEHivw14m8TXH9n2Hgv8AsaHU/C+vafJP9ot/s9pc30kTx+cEbeXJhZpTGkgDyjDSDc9ezUUAeQX2leIvEGveL9a8QaTF4N0W40OwNnqWoX0Ms1hdWVxc3Ec8sUbGLEbuspBlKFUjBzvkSKC48J6rrngvw74mvNI1WbU7zWP+El1bTbK7bT79fNspbeO3jfzIQrwJJbxMS8W9YHYje5Vug0fWtT8cWNrrurfDnT7rw8tnBr+hzG9jubqWZgXgUQyRokE6pyW83arSKFdhuZeg0PxZ/bPgfwt4kXR7syeILe1nW1th532fzoxIxeQ7VCIu4lm2527VBdkRgDz/AE3wk2i/EDwvr1n8Lbvy9O0fVd1wb22vLmKe4uFnjR5p5hI0xAuAxBZFe7KiRkLuO6+GdjqelfCbwppGtabLpuo6dpdvZXFtLJG5V4oxGTujZlIO3cMHOCMgHIHWVmaXq8euWOl6xpBiudF1GzF3FdFnSRg4RosRlOjKzEklSpCjadx2gHibeFfFE3w5bSbj4b3c9k1xokCaNdzadPcwWtrdCea2MwkSOezSNRHF5rGZnklMg2tuHQNpPipfGmq+IF8H6g8Fj4sXWIIRcWnmahbnSDp5MOZtoIkHmESmP92RjL5Qev0UAeTaXofibw3e6J4lPhu71R1/t3ztNsp7cXMH9oahHeRbjLKkR2JGUfbI2HI271ywxda8NeL4/HE2uaX4Lu1ttH0fSlsdHsriy/svUbm2knYwHe0cipELoGJysYR4fM8tzHEj+50UAQ2k0lzYwXE1pLZyyxq7W8xQyQkjJRijMuR0O1iMjgkc1NRRQAUUUUAcZ8NP+RRvv+xg1v8A9Ot1XZ1xnw0/5FG+/wCxg1v/ANOt1XZ0AFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFAH5NfFj/kt/jz/sYL//ANKXoo+LH/Jb/Hn/AGMF/wD+lL0UAfpl8J/+SIeA/wDsX7D/ANJkrs68g+GWofElPg94LSx8J+Gp7RdDshDLN4huIpHT7Om1mQWTBSRgkBmAPGT1rrP7S+Kf/Qm+Ff8Awprn/wCQKAOzorjP7S+Kf/Qm+Ff/AAprn/5Ao/tL4p/9Cb4V/wDCmuf/AJAoA7OiuM/tL4p/9Cb4V/8ACmuf/kCj+0vin/0JvhX/AMKa5/8AkCgDs6K4z+0vin/0JvhX/wAKa5/+QKP7S+Kf/Qm+Ff8Awprn/wCQKAOzorjP7S+Kf/Qm+Ff/AAprn/5Ao/tL4p/9Cb4V/wDCmuf/AJAoA7OiuM/tL4p/9Cb4V/8ACmuf/kCj+0vin/0JvhX/AMKa5/8AkCgDs6K4z+0vin/0JvhX/wAKa5/+QKP7S+Kf/Qm+Ff8Awprn/wCQKAOzorjP7S+Kf/Qm+Ff/AAprn/5Ao/tL4p/9Cb4V/wDCmuf/AJAoA7OuM+LH/JEPHn/Yv3//AKTPR/aXxT/6E3wr/wCFNc//ACBWN4stPin4o8D694Z/4Rfwraf2vp9xY/aP+EiuX8rzY2Tft+wjdjdnGRnHUUAc/wCEPCq2vxZudZ1J/Ev/AAkf9qajLOV02GO0Nm8k32YSXxgV7iMRNb7YRPIUcR/IohPl8lY6D4kht7K18OeD/EFp4ofwPqum6nqiqbSJtaaO1JlMkjoHmaWM5uUDeaWQiR1icxezf2l8U/8AoTfCv/hTXP8A8gUf2l8U/wDoTfCv/hTXP/yBQB5BfeE/Dun+BrmPRLbx1cafLrmjSmKHRJtLCmK7DzvHa2NtbyZEG5mmaPBKwBHMkShLl1p+k6LfeIbzSfCetWsukeLNMi0dbPQr0x2Vjm1N6bNEi2xxv5d/5rQgCUMAxYSR7vU/7S+Kf/Qm+Ff/AAprn/5Ao/tL4p/9Cb4V/wDCmuf/AJAoA852X1h8cNI1FfD0thLLrlzDfyWnh2+nuJbV4LhIXn1QFopoGc2ziHAWDManaLc4PiGl9afEVNZg8PSx3drqmmvFe2vh2+1S9nsxLAbhob2ElLSPZ9oRrbaS4WVsH7RXo39pfFP/AKE3wr/4U1z/APIFH9pfFP8A6E3wr/4U1z/8gUAeQXGix+JNK0p9fsvEtn4cg1TxDLNCPDL3cjXE+oiezc2lzaTEgwPMRMIvkJZC6lmRus8LeFdIm+L902s6L4gv5rHw/o5t7nxFHPcol3AZ97+ad1sblFkgJeInDvMUOWmJ7P8AtL4p/wDQm+Ff/Cmuf/kCj+0vin/0JvhX/wAKa5/+QKAPnO70Hw/qvgfULq68NbNeTwveafp99YaXeNe+JL6eOMi5a4jgVJJmETswhmuVkjnuGMjQq7P7NaW+kXXxG1DVdZ8J6rf6tfahaXWg6gNMnSW0sfstsGU3LKotUEq3TPbu6MwaQGN/OCuaX4V8W6NqkOoWHgPw+Ht8/ZYJvGuoz21nlSv7iCSzaKDCFkHlqu1GZBhSQem/tL4p/wDQm+Ff/Cmuf/kCgDjND0eaL4h6bKug3cHiWLxBqdxrGqtYSJ9o0txefZY2vCoSdAJLDbCJGKeWnyr5J2ezVxn9pfFP/oTfCv8A4U1z/wDIFH9pfFP/AKE3wr/4U1z/APIFAHZ0Vxn9pfFP/oTfCv8A4U1z/wDIFH9pfFP/AKE3wr/4U1z/APIFABpv/Jb/ABR/2L+kf+lOpV2deZ21p8U7fxxqnib/AIRfwq32/T7Ox+z/APCRXI8vyJLl9+77Dzu+04xgY2dTnjZ/tL4p/wDQm+Ff/Cmuf/kCgDs6K4z+0vin/wBCb4V/8Ka5/wDkCj+0vin/ANCb4V/8Ka5/+QKAOzorjP7S+Kf/AEJvhX/wprn/AOQKP7S+Kf8A0JvhX/wprn/5AoA7OiuM/tL4p/8AQm+Ff/Cmuf8A5Ao/tL4p/wDQm+Ff/Cmuf/kCgDs6K4z+0vin/wBCb4V/8Ka5/wDkCj+0vin/ANCb4V/8Ka5/+QKAOzorjP7S+Kf/AEJvhX/wprn/AOQKP7S+Kf8A0JvhX/wprn/5AoA7OiuM/tL4p/8AQm+Ff/Cmuf8A5Ao/tL4p/wDQm+Ff/Cmuf/kCgDs6K4z+0vin/wBCb4V/8Ka5/wDkCj+0vin/ANCb4V/8Ka5/+QKAOzr5Z1mz1K4+CHhCbT9A86/h8D2baTfjQrvWJ/tf2YkLamBgNOmUiJvtDD5y8fX7PXuf9pfFP/oTfCv/AIU1z/8AIFY3hO0+KfhfwPoPhn/hF/Ct3/ZGn29j9o/4SK5TzfKjVN+37CduducZOM9TQBwvgyx0/Rb7wlqGn+H/ABLDf3PizVoby8u9L1F7j+z5DeNAs0syF1gZ5rOTDEIZN0jfOkrA8JRCw8e+Xq/hKWz0vUND1CPWbC18KX7B7jdA4ivLtvMTU5Ni3SrOB+8JkxuM4B9T/tL4p/8AQm+Ff/Cmuf8A5Ao/tL4p/wDQm+Ff/Cmuf/kCgDyb4XwaL4b1TwLPa+EfEGkTWng+5ttZC+HNQhi+2hbKQkr5IR5nEE4LqC0hRFJY+WKxdasdYk+DHhlIPCl3DrGn+D4LawuLrw1f6heRX8UTo0duqFTp0yOkZFwy/vd8ZBZYBXuf9pfFP/oTfCv/AIU1z/8AIFH9pfFP/oTfCv8A4U1z/wDIFAHJ/wBmeHda8c6vN4o8FahrN3q15bSaPczaTNmHTmtLdXjed1VbePzBdmS2kdGcNIpjfzgsnMfCPTLLRfEXw+jtfBWtaBOPCc9nqLyaTcW9vJdn7Exkf5diSM0FyrPIEd/JTO5GgLep/wBpfFP/AKE3wr/4U1z/APIFH9pfFP8A6E3wr/4U1z/8gUAeZ6boduvw5tbKDwZqsPiWC305fFtyunSwrqOy6tmvllJAGpO6JdfNGJ96mVQ378LL6N8N7KOztPELabpUuk+HrjVPN0eyks3shDb/AGW3Vwtu6q0INwtw20ou4sXwQ4Yzf2l8U/8AoTfCv/hTXP8A8gUf2l8U/wDoTfCv/hTXP/yBQB2dFcZ/aXxT/wChN8K/+FNc/wDyBR/aXxT/AOhN8K/+FNc//IFAHZ0Vxn9pfFP/AKE3wr/4U1z/APIFH9pfFP8A6E3wr/4U1z/8gUAdnRXGf2l8U/8AoTfCv/hTXP8A8gUf2l8U/wDoTfCv/hTXP/yBQAfDT/kUb7/sYNb/APTrdV2deZ+GbT4p+HdIn0//AIRfwrdebqF9fb/+EiuUx9oupbjZj7Cfu+btz325wM4Gz/aXxT/6E3wr/wCFNc//ACBQB2dFcZ/aXxT/AOhN8K/+FNc//IFH9pfFP/oTfCv/AIU1z/8AIFAHZ0Vxn9pfFP8A6E3wr/4U1z/8gUf2l8U/+hN8K/8AhTXP/wAgUAdnRXGf2l8U/wDoTfCv/hTXP/yBR/aXxT/6E3wr/wCFNc//ACBQB2dFcZ/aXxT/AOhN8K/+FNc//IFH9pfFP/oTfCv/AIU1z/8AIFAHZ0Vxn9pfFP8A6E3wr/4U1z/8gUf2l8U/+hN8K/8AhTXP/wAgUAdnRXGf2l8U/wDoTfCv/hTXP/yBR/aXxT/6E3wr/wCFNc//ACBQB2dFcZ/aXxT/AOhN8K/+FNc//IFH9pfFP/oTfCv/AIU1z/8AIFAH5m/Fj/kt/jz/ALGC/wD/AEpeiofia10/xh8aPfQxQXba5emaKGUyxo/2h9yq5VSwByASqkjnA6UUAfdb+KvHHgf9mfwv4t0N9DfStP8AC+kf6PeW00s80ziONvmWRFRAroRwxJ3Djg16TN4vfwZFbxfEnWNPjl1LUBZ6bc6fYXKQy7lQIkmTII5C5fAL4KjI6Njh5PCet+Of2QfCnhTQWsY7m/0PSg0t7M8aRokcUhI2o5Y5QDHHDE54wen+IvhbxZ4usfBx0210hLnSNXttZvI7m+lWMvCD+5jYQsWDF2+cquAo+U5wACyvxm+GrAM3iTy4wyJLLLZ3EcdszOyKszsgWElkYASFScZ6VqX3xF8H6b4pPhm61SQaos1vbvHHaTypFJOcQo8ioUQv2DMPXpXCfFL4bePPHK+IrCx1rSZdK1G3tUsYb7zYzp7xSq8mAgZWMmD+8I3KPlAwTVnV/hz4p1D4u6X4802bS9CuIbqFb6ezuZjJe2SxL5lvMhTZKxk3hX+QqgU4J4UA0/D/AMYvDWqw+Lr7Ujc6Npnh2/ltXu76yngj2RrErFnZdocySMBHneRt+XrV6X4wfDuHw/f69LrzpY6bNHDek2Nx5lo0gyhlj8vfGrdmZQpJAByRXFah8IPFWoeD/iP4S/tjSoLDxNq02sWdxskeVJHmikCSDgKo8orkFid2eNu01PEXwl8e+ItB+IMlzc6BHrHjObTg0MdxMLezitAPmDmItIzFQNu1QMk5OMEA9Ak+L3w/j1ePSW1e6N7LLLBDEul3bedJGod0jIiw7BSrYUnIZSM7hlLj4xfDa206w1CTxRE1vf2z3kJiglkYQKxRpXVULRoGBUs4UAgg9DVXxB4W8Wax8Tvh/wCKobXSIbXw9HcfbIWvpN5a4jEcix4gwwQDKk7d/QhOteX6L8DfiLougraW9/4ca4l8O3nhmYPPOUEU9w84uFIiBLAysvlkY+UHf82FAPZpPif4Gj1yDRl1z7RdTNaoptraaeINc4+zhpUQxr5gIK7mGRz0qh8S/iRpfgnQtQhh1ezh8Rpp8uoWlpPbS3IdI+SXWMgojEFA7MqgnvjB4+1+D/iXS/GnhTWtG1HTdPfRVs7G7v7WSWKbU7CG3jR4p4SGR2Z1badw2KF5Y/d1viD8OfFGveMNS8QeG73Sx/anhe58NzQagZE8oSMzrMrIG3cnBUgcc57UAatt8W/CuneEfDeoeLtYgsNT1XR4NVlt7eCWXyo2jUvIVQOY4gxI3OccdeDUlh421K8+N58IwzabeeH7nw6uu2dzbxt5h3TLEB5m8o6kbmBCjhlHbJ4eb4N+Ip38M310NNu5bLwyPDGo6eNWvLWGWNG+WVZYVVpAwzuidQvOM8bq6nRfAWvaL8YNO8Q20OlJ4esPDcfh2NI7mYTBUYSCQRsjDG4bNplY7fmLE/LQB0t98RfB+m+KT4ZutUkGqLNb27xx2k8qRSTnEKPIqFEL9gzD16Vh6L8UtHfRNV1jXtWtRbRa9Jo9mlnYXiz78KY4HhePzDccncEUj06GszXfhx4kvvjLp/jrRbnTtGaC8iW6ubaaVZr+wWNd8E8W0pIxfcFbK7FC/eP3cOP4TeJr7wr4n0HxDpfhy7g1zxHPruBf3BaASRtgRyCFTHKkixYkwwKs+V4AYA6nUfjL4bg1rwfZ6bDqOoW3iKS7xPDpd05SO3WQOAgj3lxKqqV2khcscDaTd/4XP8Mz9o8vxOkywRyy7obWeRZkiOJWiKoRME5LGPdtALHABI5qD4c/EKGL4aalceI9O1XxB4US9ivLm+MjLOtwmwMCqhnKKAOdu/GSVJrnNP8AgRreleErjQYk0rUbizttRtdK1G71W+BVLtXRv9Hw0UBCSEsUDhyoGFJ3gA9G/wCF1fDL7Ibr/hJh5YhjuT/odxu8h1LLNt8vPlYBzJjap4JB4q9a/FT4f3usW2l2viWCaa6uBaW8yRyG3mnKhhEk+3ymfDA7QxPI4rztPhP42Pk+Y2iLnwE/g+XbeTHZKN+yZf3I3KcR5BwV3NjdtG7N0/4RfFNdJ8L2mtat4e1CTw9rNhf27faJ12W1tH5Ytk/d4XOAxYLlifm+6DQB6xrfxO8FeHdeu9C1jU7i31G0tDfywjT7mT/RxjMqlYyHQZ5KkhcNnG04NZ+KPgLQI7J9T8RRIL2zGoQ+TFJOTanH79hGrFI+fvthfeuV8X/D7xZ4g+IviDXLMaRHp2peE7jw3EZbuUSq8m6RZWQQkY3kKQGPy/NnPyVhTfBvxFO/hm+uhpt3LZeGR4Y1HTxq15awyxo3yyrLCqtIGGd0TqF5xnjdQB3h+MPw7+13VpHrss89rJDFJHBp9zKSZgTCy7YzvVwPldcq2VwTuXNTUvjF4NHgtte0fV3dbpLmOwnm0q9eFpoY9zeYEiLBF6scD5VfB+VsVvh34B1zwf488T6lcwaSmj6la2NrZraXMzyQraQiFAUkTgOvzH94xUgLl/vVif8ACndV07/hYy6Td2M1t4gjuU0aznkaGOwa8RRdsxWNv4kUqADwu35dxNAHWt8VvCGj+H9DufE3iG0ivdR0uLU2FnbzyJ5RUFp9uwvHDk8NIFx35Bq9J8T/AANHrkGjLrn2i6ma1RTbW008Qa5x9nDSohjXzAQV3MMjnpXml38JfHhsLB7C70FbxvBh8HXsU00zRxpni5jcRgsSOdhVcHjcetXLX4P+JdL8aeFNa0bUdN099FWzsbu/tZJYptTsIbeNHinhIZHZnVtp3DYoXlj90A9A0X4neA/EWux6Jo3iOC7vZvN8hQjqlz5ZxJ5MjKEl299hbFdhXh3gb4Q+K/Dmu+CV1XVtJl0jwZ/aX2WS2WTz737UT/rFYBYtobsz5x2r3GgAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigD8mvix/yW/wAef9jBf/8ApS9FHxY/5Lf48/7GC/8A/Sl6KAPvL4ceH/AMnw/8BaTfeLNVt9f1Hw/ZXUWmJ4wv4JZVNuGLRW63Iwg2vwihQFOMAcdbN4V+Htt4itvDlx4u1qHWrqMzQadJ421JbiZBuJZYzdbmHyPyBj5T6GvM0tLqXwV8I9U021ludU0TwHJq9nDboWmne3bSZGgjK/MpmjEkBIBO2ZhtYEqes8K/8TP432njB/m/tzT9a+yMfnxZQXOmwQeXJ/HDJ5b3KYwv+lsRuyXYA7P/AIVp4d/6CXir/wAKzVf/AJJo/wCFaeHf+gl4q/8ACs1X/wCSa8s1Lx/45t/Dut32k6vqDRXnhPUPEWn6pqun2f2dzb/Z2R7KGF/NSN0uGIW73uv7nO4rIrdb4m/4WVba5ofhTQvE/wBsv9St77VLq7ke3sPKELWsYhhzaXIEObhiFdHk+7mY7SHAOm/4Vp4d/wCgl4q/8KzVf/kmj/hWnh3/AKCXir/wrNV/+Sa4zXfF3iz+w9Y1eDxHaQzeG/B9r4jI0dIprHVLiRbpnVmlRnNsTaLs8to32yNliSpXoJtX1wfGC2s7jxFLa6Qbw2cFraRW01rct9haY285P+kQ3QO+cMMQmGOMffkOQDT/AOFaeHf+gl4q/wDCs1X/AOSaP+FaeHf+gl4q/wDCs1X/AOSau+OtUv8ASPCgm02f7Nc3WoWGnicKrNCtzeQ27SIGBXeqysy7gy7gMqwyDw3iC78fp4i0zwP4W8YRardmO9u7q9mmtrS7hEP2PbDKwtJ4iT9sL4FvGShi5+VjKAXNZ0b4d6Bq1npWp694wS7u5IYkWHxFrU4iM0oihMrRzMsIeQ7VaQqGKsATtbF2/wDCfgPTNZ0jRb7xF4lg1HWZJIrG2Pi3VTJcGONpJCALjoqqSWOACVGcsoPM6fdanb+NfEfjXU/HEUC23gvS9SumsYI7vS2O2/JdAEE8kCsrSoFlV23kFiNqrSsdb8ST/Fjwx4c8QR60FsdUgvYX10WP2omfTdYRhmxPleWPs67cgPuL5JG3AB6N/wAK08O/9BLxV/4Vmq//ACTR/wAK08O/9BLxV/4Vmq//ACTXM+F9a+IOqeOP7V1DVNKg8NXOsalpUdlLeqHdbaS4jTyIRbK/nE2wdi1zIuzzSEX5RGeBfFviDUvHGn2l1darqGj65o9xq1te39vZwQTCOS2CNZpAxmjhZbknZc7pAPKGdwkyAdN/wrTw7/0EvFX/AIVmq/8AyTR/wrTw7/0EvFX/AIVmq/8AyTXZ0UAcZ/wrTw7/ANBLxV/4Vmq//JNH/CtPDv8A0EvFX/hWar/8k12dFAHGf8K08O/9BLxV/wCFZqv/AMk1zPxC8E6Xofws8W63pes+Kre/0/R7y6tpf+Eq1NvLlSF2RsNcEHBAOCCK9ZrjPix/yRDx5/2L9/8A+kz0AUtU8FeCND0ubVNb8SeINMsIMebdXnjLU4Yo8sFG52uQBkkAZPUgVTn0D4Z2v9kfafG+qw/23t/szzPHOoL9v3bdvk5uv3ud6Y25zuX1FbPxY/5Ih48/7F+//wDSZ65/WLTxpB48+Hb+I9f0XUbQ65MFisNHltJA/wDZd9hi73UoIxuGNoOSDnjBAOg/4Vp4d/6CXir/AMKzVf8A5Jo/4Vp4d/6CXir/AMKzVf8A5JryzxH4s+LUPh3xX4v07xDoul6dBJrVrZxXcyTHFl9pVfItvs6N55+y7iXuZUA8x/KIwidB4k1jx34f/wCEy/4rH7T/AMIz4fj8S/8AIPhT7TcN9r/0XodlmPsn3eZ/n/4+Pl5AOz/4Vp4d/wCgl4q/8KzVf/kmj/hWnh3/AKCXir/wrNV/+Sa5/VvEXiKHxFreqW+tSw2mjeJNL0FNLWGE29zFdfYfMlkYoZfMH219uyRV/dx5U/Pv5/xDqnxQ/tTxFeab4+tLCHSPGGm6Xb2a6LHJFLbXS2QMcpZ97bTdKcoyEkS8gPGIQD0D/hWnh3/oJeKv/Cs1X/5Jo/4Vp4d/6CXir/wrNV/+Sa4z4geIPFHg/S9Q/sfxB4g1698O6O+rXAjtNOVWBaZo2vmcR7oW8hkCWqJIqxSFiWeMifT9U8Ya949s47TxJrUMUGuXkep2Vtp0B02OwgadItl09u2+R2S2WREnZ1aSYbYyhEYB01t8PfDF3C0sWoeMFVZHiIl8T6vEco5QnDXAJGVOG6MMMCQQTN/wrTw7/wBBLxV/4Vmq/wDyTXM2/iTxNP8ADmzW91u7l8QXfiDUtLR9FsbdLi78i6uwI7dbljBDiK33EzF/kjZctIytXW/DrW9T1/wNDfaxHLHfRXl7ZSCcRibFvdywKZfKJj8wrEC/l/JuLbQFwAAQf8K08O/9BLxV/wCFZqv/AMk0f8K08O/9BLxV/wCFZqv/AMk12dFAHGf8K08O/wDQS8Vf+FZqv/yTR/wrTw7/ANBLxV/4Vmq//JNdnRQB5NZeCdLm+KevaJJrPiprC00fTrqGL/hKtT+SWWa9WRs/aMnIhiGCcDbxjJz03/CtPDv/AEEvFX/hWar/APJNGm/8lv8AFH/Yv6R/6U6lXZ0AcZ/wrTw7/wBBLxV/4Vmq/wDyTR/wrTw7/wBBLxV/4Vmq/wDyTXZ0UAcZ/wAK08O/9BLxV/4Vmq//ACTR/wAK08O/9BLxV/4Vmq//ACTXZ0UAcZ/wrTw7/wBBLxV/4Vmq/wDyTR/wrTw7/wBBLxV/4Vmq/wDyTXZ0UAcZ/wAK08O/9BLxV/4Vmq//ACTR/wAK08O/9BLxV/4Vmq//ACTXZ0UAcZ/wrTw7/wBBLxV/4Vmq/wDyTR/wrTw7/wBBLxV/4Vmq/wDyTXZ0UAcZ/wAK08O/9BLxV/4Vmq//ACTR/wAK08O/9BLxV/4Vmq//ACTXZ0UAcZ/wrTw7/wBBLxV/4Vmq/wDyTR/wrTw7/wBBLxV/4Vmq/wDyTXZ0UAcZ/wAK08O/9BLxV/4Vmq//ACTXM/D3wTpeufCzwlreqaz4quL/AFDR7O6uZf8AhKtTXzJXhRnbC3AAySTgACvWa4z4T/8AJEPAf/Yv2H/pMlAB/wAK08O/9BLxV/4Vmq//ACTR/wAK08O/9BLxV/4Vmq//ACTXZ0UAcZ/wrTw7/wBBLxV/4Vmq/wDyTR/wrTw7/wBBLxV/4Vmq/wDyTXZ0UAcZ/wAK08O/9BLxV/4Vmq//ACTR/wAK08O/9BLxV/4Vmq//ACTXZ0UAcZ/wrTw7/wBBLxV/4Vmq/wDyTR/wrTw7/wBBLxV/4Vmq/wDyTXZ0UAcZ/wAK08O/9BLxV/4Vmq//ACTR/wAK08O/9BLxV/4Vmq//ACTXZ0UAcZ/wrTw7/wBBLxV/4Vmq/wDyTR/wrTw7/wBBLxV/4Vmq/wDyTXZ0UAcZ/wAK08O/9BLxV/4Vmq//ACTR/wAK08O/9BLxV/4Vmq//ACTXZ0UAeTeB/BOl6x4cu7vUdZ8VTzR6xqlqrf8ACVamuIodQnhiXAuAOEjQZ6nGTkkmum/4Vp4d/wCgl4q/8KzVf/kmj4af8ijff9jBrf8A6dbquzoA4z/hWnh3/oJeKv8AwrNV/wDkmj/hWnh3/oJeKv8AwrNV/wDkmuzooA4z/hWnh3/oJeKv/Cs1X/5Jo/4Vp4d/6CXir/wrNV/+Sa7OigDjP+FaeHf+gl4q/wDCs1X/AOSaP+FaeHf+gl4q/wDCs1X/AOSa7OigDjP+FaeHf+gl4q/8KzVf/kmj/hWnh3/oJeKv/Cs1X/5Jrs6KAOM/4Vp4d/6CXir/AMKzVf8A5Jo/4Vp4d/6CXir/AMKzVf8A5Jrs6KAOM/4Vp4d/6CXir/wrNV/+SaP+FaeHf+gl4q/8KzVf/kmuzooA4z/hWnh3/oJeKv8AwrNV/wDkmj/hWnh3/oJeKv8AwrNV/wDkmuzooA/JT4m20dl8YfGlnC0rRQa5exK00zzSELcOAWdyWc8csxJJ5JJoqb4sf8lv8ef9jBf/APpS9FAH6P8Awt8PaBc/DH4deI7jQ9Pm1q18N2EMGoyWyNcQobZQVWQjco+d+AcfMfU11sXhPwrBqmn6pD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)**Tabla 3: Todas las reacciones ad** **versas notificadas en pacientes adultos en estudios clínicos de fase III o por uso poscomercialización\* y en dos estudios de fase II y dos de fase III en pacientes pediátricos**

  ![](data:image/jpg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD/2wBDAAUEBAQEAwUEBAQGBQUGCA0ICAcHCBALDAkNExAUExIQEhIUFx0ZFBYcFhISGiMaHB4fISEhFBkkJyQgJh0gISD/2wBDAQUGBggHCA8ICA8gFRIVICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICD/wAARCARcAEwDASIAAhEBAxEB/8QAHwAAAQUBAQEBAQEAAAAAAAAAAAECAwQFBgcICQoL/8QAtRAAAgEDAwIEAwUFBAQAAAF9AQIDAAQRBRIhMUEGE1FhByJxFDKBkaEII0KxwRVS0fAkM2JyggkKFhcYGRolJicoKSo0NTY3ODk6Q0RFRkdISUpTVFVWV1hZWmNkZWZnaGlqc3R1dnd4eXqDhIWGh4iJipKTlJWWl5iZmqKjpKWmp6ipqrKztLW2t7i5usLDxMXGx8jJytLT1NXW19jZ2uHi4+Tl5ufo6erx8vP09fb3+Pn6/8QAHwEAAwEBAQEBAQEBAQAAAAAAAAECAwQFBgcICQoL/8QAtREAAgECBAQDBAcFBAQAAQJ3AAECAxEEBSExBhJBUQdhcRMiMoEIFEKRobHBCSMzUvAVYnLRChYkNOEl8RcYGRomJygpKjU2Nzg5OkNERUZHSElKU1RVVldYWVpjZGVmZ2hpanN0dXZ3eHl6goOEhYaHiImKkpOUlZaXmJmaoqOkpaanqKmqsrO0tba3uLm6wsPExcbHyMnK0tPU1dbX2Nna4uPk5ebn6Onq8vP09fb3+Pn6/9oADAMBAAIRAxEAPwD4yooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAor7M/4YY/6qj/5RP/uiqt7+xRa6fCJbr4rbFOcf8SPJOBnoLj0oA+PaK+rY/wBkKwa4lif4mTxhCqhm0BsEsMj/AJb8Vtw/sPRzxJLF8VA6OoZWGi5BH/gRQB8b0V9mf8MMf9VR/wDKJ/8AdFH/AAwx/wBVR/8AKJ/90UAfGdFfZn/DDH/VUf8Ayif/AHRXgHxr+FP/AAp7xvZ+Gf7e/tv7Tp6X32j7L9n27pJE2bd75/1ec579OKAPMqKKKAP2Yrkb6ee4tNTm1Dy7UWTu1vMM8JtOScjnOO2a601wGoQPFo1/JeRyFSDDhpjvZSGyT2BIAH/66AKIaO1h0y7bVS0d6yeVsQkvxjjjqAe9djpst1HqraesCR6dFAvlEBt2eMgnp3rho7i2j02xjmhMsEWw26BsGMrzjPcdq7Gwgmi1xGCt5DKzBlkJ6heGB9+mKAOlooHQUUAFfAH7a3/Jb9G/7F+H/wBKbivv+vgD9tb/AJLfo3/Yvw/+lNxQB8zUUUUAfss+7Ydgy2OB0rlT4fvJIbyK4TzluTu/1oXaeeeBz1711h4Ga8o1Pxr4136hqWmaPHFpNg2GNyhDuPXqP0oA6S38KyQsFa3EsYxhWm6cYPbvitGDTdSg1eTUAoYOu3yjIMAfXGe1ecRePPiBLNp1olnYGXVE821bacMvPH3uvFeh+CvEU3iTQWurqEQ3cErQTovQOMdPzoA2PO1L/nyj/wC/3/1qPO1L/nyj/wC/3/1qvUUAUfO1L/nyj/7/AH/1q+Cf2zmnb416ObiIRt/YEPAbdx9ouK/QSvgD9tb/AJLfo3/Yvw/+lNxQB8zUUUUAfsuc44rxGcfEW9utftNStriSye3lXZ5fyf7Hl46nOOle30m0elAHkFjo+qJrHgGRtOuFS0t2WcmM/ujz970rpvhrY3ljpurpeWstu0moSSIJFK7lIGCM9q7navpQABQAtFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S36N/wBi/D/6U3FAHzNRRRQB+zFFFFABRRRQAUUUUAFfAH7a3/Jb9G/7F+H/ANKbivv+vgD9tb/kt+jf9i/D/wClNxQB8zUUUUAfsxRRRQAUUUUAFFFFABXwB+2t/wAlv0b/ALF+H/0puK+/6+AP21v+S3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 **Trastornos oculares** 
  
 Hemorragia ocular

          (incl. hemorragia conjuntival)         
 **Trastornos cardíacos** 
   Taquicardia       
 **Trastornos vasculares** 
 Hipotensión, hematoma         
 **Trastornos respiratorios, torácicos y mediastínicos** 
 Epistaxis, hemoptisis      Neumonía eosinofílica   
 **Trastornos gastrointestinales** 
 Sangrado gingival, hemorragia del tracto gastrointestinal (incl. hemorragia rectal), dolor gastrointestinal y abdominal, dispepsia, náuseas, estreñimientoA, diarrea, vómitosA  Sequedad de boca       
 **Trastornos hepatobiliares** 
 Transaminasas elevadas  Insuficiencia hepática, bilirrubina elevada, fosfatasa alcalina en sangre aumentadaA, GGT elevadaA  Ictericia, bilirrubina conjugada elevada (con o sin elevación concomitante de ALT), colestasis, hepatitis (que incluye lesión traumática

          hepatocelular)     
 **Trastornos de la piel y del tejido subcutáneo** 
 Prurito (incl. casos raros de prurito generalizado), exantema, equimosis, hemorragia cutánea y subcutánea  Urticaria    Síndrome de Stevens-Johnson/ necrólisis epidérmica tóxica, síndrome

          DRESS   
 **Trastornos musculoesqueléticos y del tejido conjuntivo** 
 Dolor en las extremidadesA  Hemartrosis  Hemorragia muscular    Síndrome compartimental secundario a una

          hemorragia 
 **Trastornos renales y urinarios** 

  ![](data:image/jpg;base64,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 Hemorragia del tracto urogenital (incl. hematuria y menorragiaB), insuficiencia renal (incl.

          creatinina elevada en sangre, urea elevada en

          sangre)        Insuficiencia renal

          /insuficiencia renal aguda secundaria a una hemorragia suficiente para causar hipoperfusión, nefropatía relacionada con anticoagulantes 
          
 **Trastornos generales y alteraciones en el lugar de administración** 
 FiebreA, edema periférico, disminución general de la fuerza y la energía (incl. fatiga y

          astenia)  Sensación de malestar (incl. malestar general)  Edema localizadoA     
 **Exploraciones complementarias** 
   LDH elevadaA, lipasa elevadaA, amilasa elevadaA       
 **Lesiones traumáticas, intoxicaciones y complicaciones de procedimientos terapéuticos** 
 Hemorragia después de una intervención (incl. anemia postoperatoria y hemorragia de la herida), contusión, secreción de la heridaA    Pseudoaneurisma vascularC     

A  observado en la prevención del TEV en pacientes adultos sometidos a cirugía electiva de reemplazo de cadera o rodilla.

B  observado en el tratamiento de la TVP, EP y prevención de sus recurrencias como muy frecuente en mujeres < 55 años.

C  observado como poco frecuente en la prevención de acontecimientos aterotrombóticos en pacientes que han sufrido un SCA (tras una intervención coronaria percutánea).

\*  Se aplicó una estrategia selectiva preespecificada para la recopilación de acontecimientos adversos en estudios de fase III seleccionados. La incidencia de reacciones adversas no aumentó y no se identificó ninguna nueva reacción adversa al medicamento tras analizar estos estudios.

Descripción de reacciones adversas seleccionadas

Debido a su mecanismo de acción farmacológica, el uso de rivaroxabán puede asociarse a un incremento del riesgo de hemorragia oculta o manifiesta en cualquier tejido u órgano, que puede dar lugar a una anemia post-hemorrágica. Los signos, síntomas y gravedad (incluido un posible desenlace mortal) variarán según la localización y el grado o la extensión de la hemorragia, la anemia o ambas (ver sección 4.9 “Tratamiento de la hemorragia”). En los ensayos clínicos se observaron con más frecuencia hemorragias a nivel de mucosas (p.ej. epistaxis, gingival, gastrointestinal, genitourinaria, incluida hemorragia vaginal anormal o menstrual aumentada) y anemia en los pacientes que recibían rivaroxabán a largo plazo con respecto a los que recibían tratamiento con AVK. Por ello, además de un adecuado seguimiento clínico, las determinaciones de hemoglobina y hematocrito podrían ser útiles para detectar hemorragias ocultas y cuantificar la importancia clínica de la hemorragia manifiesta, cuando se considere apropiado. El riesgo de

  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hemorragia puede estar aumentado en ciertos grupos de pacientes, como por ejemplo, en pacientes con hipertensión arterial grave no controlada y/o en tratamiento concomitante que afecte a la hemostasia (ver sección 4.4 “Riesgo de hemorragia”). El sangrado menstrual puede ser más intenso y/o prolongarse. Las complicaciones hemorrágicas pueden presentarse como debilidad, palidez, mareos, cefalea o tumefacción inexplicada, disnea o shock de causa desconocida. En algunos casos, a consecuencia de la anemia, se han observado síntomas de isquemia cardíaca, como dolor torácico o angina de pecho.

Se han notificado complicaciones conocidas, secundarias a hemorragia intensa, como el síndrome compartimental e insuficiencia renal debida a hipoperfusión, o nefropatía relacionada con anticoagulantes. Por lo tanto, se debe teneren cuenta la posibilidad de hemorragia al evaluar el estado de cualquier paciente anticoagulado.

Población pediátrica

*Tratamiento del TEV y prevención de las recurrencias del TEV*

La evaluación de la seguridad en niños y adolescentes se basa en los datos de seguridad de dos estudios abiertos con control activo de fase II y uno de fase III realizados en pacientes pediátricos desde el nacimiento hasta una edad inferior a 18 años. Los resultados de seguridad fueron generalmente similares entre rivaroxabán y el tratamiento comparador en los diversos grupos de edad pediátricos. En general, el perfil de seguridad en los 412 niños y adolescentes tratados con rivaroxabán fue similar al observado en la población adulta y consistente en todos los subgrupos de edad, aunque la evaluación es limitada por el pequeño número de pacientes.

En los pacientes pediátricos se notificaron con mayor frecuencia, en comparación con los adultos, cefalea (muy frecuente, 16,7%), fiebre (muy frecuente, 11,7%), epistaxis (muy frecuente, 11,2%), vómitos (muy frecuente, 10,7%), taquicardia (frecuente, 1,5%), aumento de la bilirrubina (frecuente, 1,5%) y bilirrubina conjugada elevada (poco frecuente, 0,7%). De forma consistente con la población adulta, se observó menorragia en el 6,6% (frecuente) de las adolescentes después de la menarquia. La trombocitopenia observada en la experiencia postcomercialización en la población adulta fue frecuente (4,6%) en los estudios clínicos pediátricos. Las reacciones adversas al medicamento en los pacientes pediátricos fueron principalmente de gravedad leve a moderada.

Notificación de sospechas de reacciones adversas

Es importante notificar las sospechas de reacciones adversas al medicamento tras su autorización. Ello permite una supervisión continuada de la relación beneficio/riesgo del medicamento. Se invita a los profesionales sanitarios a notificar las sospechas de reacciones adversas a través del Sistema Español de Farmacovigilancia de Medicamentos de Uso Humano: [www.notificaram.es](http://www.notificaram.es/).