El medicamento SIRTURO 100 MG COMPRIMIDOS con los principios activos BEDAQUILINA FUMARATO tiene la siguiente información en la sección 4.8
Resumen del perfil de seguridad

Se identificaron reacciones adversas al tratamiento con SIRTURO a partir de los datos recogidos de ensayos clínicos de Fase IIb (tanto controlados como no controlados) realizados en 335 pacientes que recibieron SIRTURO en combinación con un tratamiento farmacológico de base contra la tuberculosis. La evaluación de la causalidad entre las reacciones adversas al tratamiento y SIRTURO no se basó unicamente en esos ensayos, sino también en la revisión de los datos de seguridad recogidos de los ensayos de Fase I y Fase IIa. Las reacciones adversas más frecuentes (> 10,0% de los pacientes) durante el tratamiento con SIRTURO en los ensayos controlados fueron náuseas (35,3% en el grupo de SIRTURO frente a 25,7% en el grupo de placebo), artralgia (29,4% frente a 20,0%), dolor de cabeza (23,5% frente a 11,4%), vómitos (20,6% frente a 22,9%) y mareo (12,7% frente a 11,4%). Consulte la Ficha Técnica de los medicamentos utilizados en combinación con SIRTURO para ver sus respectivas reacciones adversas.

Tabla de reacciones adversas

Las reacciones adversas al tratamiento con SIRTURO notificadas en ensayos controlados en 102 pacientes tratados con este medicamento se presentan en la siguiente tabla. A continuación se enumeran las reacciones adversas según la clase de órgano o sistema (COS) y la frecuencia. Las categorías de las frecuencias se definen como siguen: muy frecuentes (≥ 1/10), frecuentes (≥ 1/100 a < 1/10) y poco frecuentes (≥ 1/1.000 a < 1/100).

![](data:image/jpg;base64,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)

![](data:image/jpg;base64,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)

Descripción de reacciones adversas seleccionadas

*Cardiovascular*

En el estudio controlado de Fase IIb (C208), se observaron incrementos medios de los valores iniciales del intervalo QTcF desde la primera evaluación realizada durante el tratamiento (9,9 ms en la semana 1 con SIRTURO y 3,5 ms con placebo). El mayor aumento medio de los valores iniciales del intervalo QTcF durante las 24 semanas de tratamiento con SIRTURO fue de 15,7 ms (en la semana 18). Una vez finalizado el tratamiento con SIRTURO (es decir, después de la semana 24), los aumentos de los valores iniciales del intervalo QTcF en el grupo de SIRTURO se hicieron gradualmente menos pronunciados. El mayor aumento medio del intervalo QTcF en el grupo de placebo durante las primeras 24 semanas fue de 6,2 ms (también en la semana 18) (ver sección 4.4). En el estudio abierto de Fase IIb (C209), cuando los pacientes sin opciones de tratamiento recibieron otros medicamentos que prolongan el intervalo QT, utilizados para tratar la tuberculosis incluyendo clofazimina, el uso concomitante con SIRTURO dio lugar a una prolongación del intervalo QT adicional, proporcional al número de medicamentos que prolongan el intervalo QT en el régimen de tratamiento.

Los pacientes que recibieron solo SIRTURO, sin otro medicamento que prolonga el intervalo QT desarrollaron un aumento del intervalo QTcF medio máximo de 23,7 ms sobre el punto de referencia, sin una duración en exceso del intervalo QT de 480 ms, mientras que los pacientes con al menos 2 medicamentos que prolongan el intervalo QT desarrollaron una prolongación del intervalo QTcF medio máximo de 30,7 ms sobre el punto de referencia, originando una duración del intervalo QTcF en exceso de 500 ms en un paciente.

No existen casos documentados de Torsade de Pointes en la base de datos de seguridad (ver sección 4.4). Para más información en relación a pacientes que utilizan conjuntamente clofazimina, ver sección 4.5, intervalo QT y uso concomitante de clofazimina.

*Aumento de las transaminasas*

En el estudio C208 (fases 1 y 2), los aumentos de la aminotransferasa en al menos 3 x LSN fueron más frecuentes en el grupo tratado con SIRTURO (11/102 [10,8%] frente a 6/105 [5,7%]) que en el grupo de tratamiento con placebo. En el grupo de tratamiento con SIRTURO, la mayor parte de esos aumentos tuvieron lugar durante las 24 semanas de tratamiento y fueron reversibles. Durante el período de investigación en la Fase 2 del estudio C208, se notificó un aumento de las transaminasas en 7/79 (8,9%) de los pacientes tratados con SIRTURO, en comparación con 1/81 (1,2%) en el grupo tratado con placebo.

Notificación de sospechas de reacciones adversas

Es importante notificar sospechas de reacciones adversas al medicamento tras su autorización. Ello permite una supervisión continuada de la relación beneficio/riesgo del medicamento. Se invita a los profesionales sanitarios a notificar las sospechas de reacciones adversas a través del sistema nacional de notificación incluido en el [Apéndice V](http://www.ema.europa.eu/docs/en_GB/document_library/Template_or_form/2013/03/WC500139752.doc)