El medicamento CYSTADANE 1 g POLVO ORAL con los principios activos BETAINA ANHIDRA tiene la siguiente información en la sección 4.8
Resumen del perfil de seguridad

En general, las reacciones adversas observadas durante la terapia con betaína anhidra no parecieron ser graves y guardan relación principalmente con el tracto gastrointestinal. Los trastornos gastrointestinales como diarrea, glositis, náuseas, molestias gástricas, vómitos y trastornos dentales pueden aparecer con menor frecuencia.

La reacción adversa notificada con mayor frecuencia durante el tratamiento es un aumento de la metionina en sangre. Se observó una recuperación completa tras la interrupción del tratamiento (ver sección 4.4).

Tabla de reacciones adversas

Las reacciones adversas comunicadas se enumeran a continuación por frecuencia y clasificación de órganos del sistema.

Las frecuencias se definen como: muy frecuentes (≥ 1/10), frecuentes (≥ 1/100 a < 1/10), poco frecuentes (≥ 1/1.000 a < 1/100), raras (≥ 1/10.000 a < 1/1.000), muy raras (< 1/10.000). Las reacciones adversas se presentan en orden decreciente de gravedad dentro de cada intervalo de frecuencia.

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)

Descripción de las reacciones adversas seleccionadas

\*Se notificaron casos poco frecuentes de edema cerebral severo e hipermetioninemia dentro de 2 semanas hasta 6 meses de comenzar la terapia con betaína anhidra en pacientes con deficiencia de CBS, con una recuperación completa después de dejar el tratamiento.

Los síntomas de edema cerebral incluyen cefaleas matutinas con vómitos y/o alteraciones visuales.

En estos pacientes se observaron aumentos elevados en los niveles plasmáticos de metionina en un rango que abarcó de 1.000 a 3.000 μM. Como también se ha comunicado edema cerebral en pacientes con hipermetioninemia, se ha postulado como un posible mecanismo de acción la hipermetioninemia secundaria debida a la terapia con betaína anhidra.

Ver sección 4.4 para las recomendaciones específicas.

Notificación de sospechas de reacciones adversas

Es importante notificar sospechas de reacciones adversas al medicamento tras su autorización. Ello permite una supervisión continuada de la relación beneficio/riesgo del medicamento. Se invita a los profesionales sanitarios a notificar las sospechas de reacciones adversas a través del sistema nacional de notificación incluido en el [Apéndice V](http://www.ema.europa.eu/docs/en_GB/document_library/Template_or_form/2013/03/WC500139752.doc).