El medicamento RIVAROXABAN STADA 20 MG COMPRIMIDOS RECUBIERTOS CON PELICULA EFG con los principios activos RIVAROXABAN tiene la siguiente información en la sección 4.8
Resumen del perfil de seguridad

Se ha evaluado la seguridad de rivaroxabán en trece estudios pivotales de fase III (ver Tabla 1).

En total, 69.608 pacientes adultos en diecinueve estudios de fase III y 488 pacientes pediátricos en dos estudios de fase II y dos de fase III fueron expuestos a rivaroxabán.

## **Tabla 1: Número de pacientes estudiados, dosis total diaria y duración máxima del tratamiento en los estudios pediátricos y en adultos de fase III.**
          **Indicación**  **Número de pacientes \***  ****

          **Dosis total diaria**  **Duración máxima del**

          **tratamiento** 
        
 Prevención de tromboembolismo venoso (TEV) en pacientes adultos sometidos a cirugía electiva de reemplazo de cadera o rodilla  ****

          6.097  ****

          10 mg  ****

          39 días 
 Prevención del TEV en pacientes encamados  3.997  10 mg  39 días 

  ![](data:image/jpg;base64,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)
          Tratamiento de la trombosis venosa profunda (TVP) y de la embolia pulmonar (EP) y prevención de las recurrencias  ****
          6.790  Días 1 a 21: 30 mg

          Día 22 en

          adelante: 20 mg Después de al menos 6 meses: 10 mg o 20 mg  ****
          21 meses 
          Tratamiento del TEV y prevención de recurrencias del TEV en recién nacidos a término y en niños menores de 18 años tras el inicio de tratamiento anticoagulante estándar  ****
          329  Dosis ajustada según el peso corporal para lograr una exposición similar a la observada en adultos tratados por TVP con 20 mg de rivaroxabán una vez al día  ****
          12 meses 
 Prevención del ictus y de la embolia sistémica en pacientes con fibrilación auricular no valvular  ****

          7.750  ****

          20 mg  ****

          41 meses 
          Prevención de acontecimientos aterotrombóticos en pacientes que han padecido un síndrome coronario agudo (SCA)  ****
          10.225  5 mg ó 10 mg respectivamente, administrado conjuntamente con AAS o bien con AAS más clopidogrel o ticlopidina  ****
          31 meses 
          Prevención de acontecimientos aterotrombóticos en pacientes con EAC/EAP  ****

          18.244  5 mg administrado conjuntamente con AAS o bien solo 10 mg  ****

          47 meses 
          3.256\*\*  5 mg administrado conjuntamente con AAS  ****

          42 meses 

\*   Pacientes expuestos por lo menos a una dosis de rivaroxabán.

\*\*   Del estudio VOYAGER PAD.

Las reacciones adversas notificadas con mayor frecuencia en los pacientes que recibieron rivaroxabán fueron hemorragias (tabla 2) (ver también sección 4.4. y “Descripción de las reacciones adversas seleccionadas” más adelante). Las hemorragias notificadas con mayor frecuencia fueron epistaxis (4,5%) y la hemorragia del tracto gastrointestinal (3,8%).

## **Tabla 2: Tasas de acontecimientos de hemorragia\* y anemia en los pacientes expuestos a rivaroxabán en los estudios pediátricos y en adultos de fase III finalizados**

 **Indicación**  **Cualquier hemorragia**  **Anemia** 
      
 Prevención del tromboembolismo venoso (TEV) en pacientes adultos sometidos a cirugía electiva de reemplazo de cadera o rodilla  6,8% de los pacientes  ****

          5,9% de los pacientes 
 Prevención del tromboembolismo venoso (TEV) en pacientes encamados  12,6% de los pacientes  2,1% de los pacientes 

  ![](data:image/jpg;base64,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)
 Tratamiento de TVP, EP y prevención de recurrencias  23% de los pacientes  1,6% de los pacientes 
          Tratamiento del TEV y prevención de recurrencias del TEV en recién nacidos a término y en niños menores de 18 años tras el inicio de tratamiento anticoagulante estándar  ****

          39,5% de los pacientes  ****
          4,6% de los pacientes 
 Prevención de ictus y de embolia sistémica en pacientes con fibrilación auricular no valvular  28 por 100 pacientes-años  2,5 por 100 pacientes- años 
 Prevención de acontecimientos aterotrombóticos en pacientes después de un SCA  22 por 100 pacientes-años  1,4 por 100 pacientes- años 
 Prevención de acontecimientos aterotrombóticos en pacientes con EAC/EAP  6,7 por 100 pacientes-años  0,15 por 100 pacientes-años\*\* 
 8,38 por 100 pacientes-años#  0,74 por 100 pacientes-años \*\*\* # 

\*              Para todos los estudios de rivaroxabán se recopilaron, notificaron y adjudicaron todos los acontecimientos de hemorragia.

\*\*              En el estudio COMPASS existe una incidencia baja de anemia debido a que se aplicó una estrategia selectiva para la recopilación de acontecimientos adversos.

\*\*\*              Se aplicó una estrategia selectiva para la recopilación de acontecimientos adversos. #              Del estudio VOYAGER PAD.

Tabla de reacciones adversas

Las frecuencias de las reacciones adversas notificadas con rivaroxabán en pacientes adultos y pediátricos se resumen en la Tabla 3, según la clasificación por órganos y sistemas (convención MedDRA) y según las frecuencias.

Las frecuencias se definen como: muy frecuentes (≥ 1/10), frecuentes (≥ 1/100 a < 1/10), poco frecuentes (≥ 1/1.000 a < 1/100), raras (≥1/10.000 a < 1/1.000), muy raras (< 1/10.000) y frecuencia no conocida (no puede estimarse a partir de los datos disponibles).

## ![](data:image/jpg;base64,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)**Tabla 3: Todas las reacciones adver** **sas notificadas en pacientes adultos en estudios clínicos de fase III o por uso postcomercialización\* y en dos estudios de fase II y dos de fase III en pacientes pediátricos**

  ![](data:image/jpg;base64,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)
 **Trastornos oculares** 
  
 Hemorragia ocular

          (incl. hemorragia conjuntival)         
 **Trastornos cardíacos** 
   Taquicardia       
 **Trastornos vasculares** 
 Hipotensión, hematoma         
 **Trastornos respiratorios, torácicos y mediastínicos** 
 Epistaxis, hemoptisis      Neumonía eosinofílica   
 **Trastornos gastrointestinales** 
 Sangrado gingival, hemorragia del tracto gastrointestinal (incl. hemorragia rectal), dolor gastrointestinal y abdominal, dispepsia, náuseas, estreñimientoA, diarrea, vómitosA  Sequedad de boca       
 **Trastornos hepatobiliares** 
 Transaminasas elevadas  Insuficiencia hepática, bilirrubina elevada, fosfatasa alcalina en sangre aumentadaA, GGT elevadaA  Ictericia, bilirrubina conjugada elevada (con o sin elevación concomitante de ALT), colestasis, hepatitis (que incluye lesión traumática

          hepatocelular)     
 **Trastornos de la piel y del tejido subcutáneo** 
 Prurito (incl. casos raros de prurito generalizado), exantema, equimosis, hemorragia cutánea y subcutánea  Urticaria    Síndrome de Stevens-Johnson/ necrólisis epidérmica tóxica, síndrome

          DRESS   
 **Trastornos musculoesqueléticos y del tejido conjuntivo** 
 Dolor en las extremidadesA  Hemartrosis  Hemorragia muscular    Síndrome compartimental secundario a una

          hemorragia 
 **Trastornos renales y urinarios** 

  ![](data:image/jpg;base64,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)
 Hemorragia del tracto urogenital (incl. Hematuria y menorragiaB), insuficiencia renal (incl.

          Creatinina elevada en sangre, urea elevada en

          sangre)        Insuficiencia renal

          /insuficiencia renal aguda secundaria a una hemorragia suficiente para causar hipoperfusión, nefropatía relacionada con anticoagulantes 
          
 **Trastornos generales y alteraciones en el lugar de administración** 
 FiebreA, edema periférico, disminución general de la fuerza y la energía (incl. Fatiga y

          astenia)  Sensación de malestar (incl. Malestar general)  Edema localizadoA     
 **Exploraciones complementarias** 
   LDH elevadaA, lipasa elevadaA, amilasa elevadaA       
 **Lesiones traumáticas, intoxicaciones y complicaciones de procedimientos terapéuticos** 
 Hemorragia después de una intervención (incl. Anemia postoperatoria y hemorragia de la herida), contusión, secreción de la heridaA    Pseudoaneurisma vascularC     

A  observado en la prevención del TEV en pacientes adultos sometidos a cirugía electiva de reemplazo de cadera o rodilla.

B  observado en el tratamiento de la TVP, EP y prevención de sus recurrencias como muy frecuente en mujeres < 55 años.

C  observado como poco frecuente en la prevención de acontecimientos aterotrombóticos en pacientes que han sufrido un SCA (tras una intervención coronaria percutánea).

\*  Se aplicó una estrategia selectiva preespecificada para la recopilación de acontecimientos adversos en estudios de fase III seleccionados. La incidencia de reacciones adversas no aumentó y no se identificó ninguna nueva reacción adversa al medicamento tras analizar estos estudios.

Descripción de reacciones adversas seleccionadas

Debido a su mecanismo de acción farmacológica, el uso de rivaroxabán puede asociarse a un incremento del riesgo de hemorragia oculta o manifiesta en cualquier tejido u órgano, que puede dar lugar a una anemia post-hemorrágica. Los signos, síntomas y gravedad (incluido un posible desenlace mortal) variarán según la localización y el grado o la extensión de la hemorragia, la anemia o ambas (ver sección 4.9 “Tratamiento de la hemorragia”). En los ensayos clínicos se observaron con más frecuencia hemorragias a nivel de mucosas (p.ej. epistaxis, gingival, gastrointestinal, genitourinaria, incluida hemorragia vaginal anormal o menstrual aumentada) y anemia en los pacientes que recibían rivaroxabán a largo plazo con respecto a los que recibían tratamiento con AVK. Por ello, además de un adecuado seguimiento clínico, las determinaciones de hemoglobina y hematocrito podrían ser útiles para detectar hemorragias ocultas y cuantificar la importancia clínica de la hemorragia manifiesta, cuando se considere apropiado. El riesgo de

  ![](data:image/jpg;base64,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)

hemorragia puede estar aumentado en ciertos grupos de pacientes, como por ejemplo, en pacientes con hipertensión arterial grave no controlada y/o en tratamiento concomitante que afecte a la hemostasia (ver sección 4.4 “Riesgo de hemorragia”). El sangrado menstrual puede ser más intenso y/o prolongarse. Las complicaciones hemorrágicas pueden presentarse como debilidad, palidez, mareos, cefalea o tumefacción inexplicada, disnea o shock de causa desconocida. En algunos casos, a consecuencia de la anemia, se han observado síntomas de isquemia cardíaca, como dolor torácico o angina de pecho.

Se han notificado complicaciones conocidas, secundarias a hemorragia intensa, como el síndrome compartimental e insuficiencia renal debida a hipoperfusión, o nefropatía relacionada con anticoagulantes. Por lo tanto, se debe teneren cuenta la posibilidad de hemorragia al evaluar el estado de cualquier paciente anticoagulado.

Población pediátrica

*Tratamiento del TEV y prevención de las recurrencias del TEV*

La evaluación de la seguridad en niños y adolescentes se basa en los datos de seguridad de dos estudios abiertos con control activo de fase II y uno de fase III realizados en pacientes pediátricos desde el nacimiento hasta una edad inferior a 18 años. Los resultados de seguridad fueron generalmente similares entre rivaroxabán y el tratamiento comparador en los diversos grupos de edad pediátricos. En general, el perfil de seguridad en los 412 niños y adolescentes tratados con rivaroxabán fue similar al observado en la población adulta y consistente en todos los subgrupos de edad, aunque la evaluación es limitada por el pequeño número de pacientes.

En los pacientes pediátricos se notificaron con mayor frecuencia, en comparación con los adultos, cefalea (muy frecuente, 16,7%), fiebre (muy frecuente, 11,7%), epistaxis (muy frecuente, 11,2%), vómitos (muy frecuente, 10,7%), taquicardia (frecuente, 1,5%), aumento de la bilirrubina (frecuente, 1,5%) y bilirrubina conjugada elevada (poco frecuente, 0,7%). De forma consistente con la población adulta, se observó menorragia en el 6,6% (frecuente) de las adolescentes después de la menarquia. La trombocitopenia observada en la experiencia postcomercialización en la población adulta fue frecuente (4,6%) en los estudios clínicos pediátricos. Las reacciones adversas al medicamento en los pacientes pediátricos fueron principalmente de gravedad leve a moderada.

Notificación de sospechas de reacciones adversas

Es importante notificar las sospechas de reacciones adversas al medicamento tras su autorización. Ello permite una supervisión continuada de la relación beneficio/riesgo del medicamento. Se invita a los profesionales sanitarios a notificar las sospechas de reacciones adversas a través del Sistema Español de Farmacovigilancia de Medicamentos de Uso Humano: [www.notificaram.es](http://www.notificaram.es/).