El medicamento CAYSTON 75 mg POLVO Y DISOLVENTE PARA SOLUCION PARA INHALACION POR NEBULIZADOR con los principios activos AZTREONAM tiene la siguiente información en la sección 4.8
Resumen del perfil de seguridad

La evaluación de las reacciones adversas se basa en la experiencia obtenida a partir de cuatro ensayos clínicos de fase 3 en los que participaron pacientes con FQ e infección crónica por P. aeruginosa y en las notificaciones espontáneas posteriores a la comercialización.

En los dos ensayos clínicos de fase 3 controlados con placebo en los que los pacientes recibieron Cayston durante 28 días, las reacciones adversas a Cayston que se presentaron con mayor frecuencia fueron: tos (58%), congestión nasal (18%), sibilancias (15%) dolor faringolaríngeo (13,0%), pirexia (12%) y disnea (10%).

Un descenso acusado de ≥ 15% en el VEF1 es una complicación asociada a los tratamientos administrados por nebulización, incluido Cayston (ver sección 4.4).

Resumen tabulado de reacciones adversas

Las reacciones adversas consideradas al menos posiblemente relacionadas con el tratamiento que se observaron durante los ensayos clínicos y la experiencia posterior a la comercialización se indican a continuación, clasificadas por órganos y sistemas y por frecuencia.

Las frecuencias se definen del siguiente modo: muy frecuentes (≥ 1/10), frecuentes (≥ 1/100 a < 1/10) y poco frecuentes (≥ 1/1.000 a < 1/100).

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)

1 Ver sección Descripción de las reacciones adversas seleccionadas

Descripción de las reacciones adversas seleccionadas

*Broncoespasmo*

Los tratamientos administrados por nebulización, incluyendo Cayston, pueden asociarse a broncoespasmo (un descenso acusado de ≥ 15% en el VEF1). Consultar la sección 4.4.

*Hemoptisis*

La inhalación de soluciones administradas por nebulización puede inducir un reflejo tusígeno que podría agravar enfermedades subyacentes (ver sección 4.4).

*Reacciones alérgicas*

Se ha notificado exantema con el uso de aztreonam y puede ser indicativo de una reacción alérgica a Cayston (ver sección 4.4).

*Descenso en las pruebas de función pulmonar*

Se ha notificado un descenso en las pruebas de función pulmonar con el uso de Cayston, pero no se asoció con una disminución sostenida del VEF1 (ver sección 5.1).

Las siguientes reacciones adversas raras y graves se han notificado después del uso por vía parenteral de otros medicamentos que contienen aztreonam: necrolisis epidérmica tóxica, anafilaxia, púrpura, eritema multiforme, dermatitis exfoliativa, urticaria, petequias, prurito, diaforesis.

Población pediátrica

Un total de 137 pacientes pediátricos de 6 a 17 años de edad con infección crónica por P. aeruginosa y un VEF1 esperado ≤ 75% han recibido Cayston en los ensayos clínicos de fase 2 y fase 3 (6-12 años, n=35; 13-17 años, n=102).

Se observó una mayor tasa de incidencia de pirexia en los pacientes pediátricos de 6 a 17 años que en los adultos.

Notificación de sospechas de reacciones adversas

Es importante notificar sospechas de reacciones adversas al medicamento tras su autorización. Ello permite una supervisión continuada de la relación beneficio/riesgo del medicamento. Se invita a los profesionales sanitarios a notificar las sospechas de reacciones adversas a través del sistema nacional de notificación incluido en el Apéndice V.