El medicamento INTRAROSA 6,5 MG OVULOS con los principios activos PRASTERONA tiene la siguiente información en la sección 4.8
Resumen del perfil de seguridad

La reacción adversa observada con más frecuencia fue el flujo vaginal. Esto es debido a la fusión de la base grasa utilizada como excipiente, que se añade al aumento esperado de las secreciones vaginales debido al tratamiento. No es necesario interrumpir el tratamiento con Intrarosa si se produce flujo vaginal (ver sección 4.4).

Tabla de reacciones adversas

En la tabla 1 siguiente se muestran las reacciones adversas observadas con prasterona 6,5 mg óvulos en los estudios clínicos.

**Tabla 1: Reacciones adversas observadas con óvulos de prasterona 6,5 mg en estudios clínicos**

![Texto

Descripción generada automáticamente con confianza 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)

**Riesgo de cáncer de mama**

    - Se ha notificado un aumento del riesgo de diagnóstico de cáncer de mama hasta de 2 veces en mujeres que siguen un tratamiento combinado con estrógenos-progestágenos durante más de 5 años.
- Cualquier aumento del riesgo en mujeres que reciben tratamiento solo con estrógenos es sustancialmente menor que el observado en mujeres que reciben combinaciones de estrógenos-progestágenos.
- El nivel de riesgo depende de la duración del tratamiento (ver sección 4.4).
- Se presentan a continuación los resultados del mayor ensayo aleatorizado controlado con placebo (estudio WHI) y el mayor estudio epidemiológico (MWS).
**Million Women Study: riesgo adicional estimado de cáncer de mama tras 5 años de tratamiento**

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)

# Tasa de riesgo global. La tasa de riesgo no es constante, sino que aumenta al aumentar la duración del uso.

Nota: Puesto que la incidencia basal del cáncer de mama es diferente según el país de la UE, el número de casos adicionales de cáncer de mama también varía proporcionalmente.

**Estudios WHI en EE. UU.: riesgo adicional de cáncer de mama tras 5 años de tratamiento**

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)
**Cáncer de ovario**

El uso a largo plazo de THS solo con estrógenos o con una combinación de estrógenos-progestágenos se ha asociado a un riesgo ligeramente mayor de que se diagnostique un cáncer de ovario (ver sección 4.4).

En un metaanálisis de 52 estudios epidemiológicos se observó un aumento del riesgo de cáncer de ovario en mujeres que estaban utilizando THS en comparación con las mujeres que nunca la habían utilizado (RR 1,43, IC 95 %: 1,31-1,56). En mujeres de entre 50 y 54 años de edad que lleven 5 años utilizando THS, eso significa aproximadamente 1 caso adicional por 2000 mujeres que utilicen THS. En mujeres de 50 a 54 años que no utilicen THS, se diagnosticarán alrededor de 2 casos de cáncer de ovario por cada 2000 mujeres en un periodo de 5 años.

**Riesgo de tromboembolismo venoso**

La THS se asocia a un riesgo relativo entre 1,3 y 3 veces mayor de TEV, es decir, trombosis venosa profunda o embolia pulmonar. La aparición de tal episodio es más probable durante el primer año de la THS (ver sección 4.4). Se presentan a continuación los resultados de los estudios WHI:

1 \*Tomado de las tasas de incidencia basales en países desarrollados.

2 \* Estudio WHI en mujeres sin útero, en el que no se demostró un aumento del riesgo de cáncer de mama.
**Estudios WHI: riesgo adicional de TEV durante 5 años de uso**

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)

**Riesgo de arteriopatía coronaria**
    - El riesgo de arteriopatía coronaria es ligeramente mayor en mujeres mayores de 60 años que utilizan THS combinada con estrógenos-progestágenos (ver sección 4.4).

**Riesgo de accidente cerebrovascular isquémico**
    - La terapia con solo estrógenos o con estrógenos-progestágenos se asocia con un riesgo relativo hasta 1,5 veces mayor de sufrir un accidente cerebrovascular isquémico. El riesgo de accidente cerebrovascular hemorrágico no aumenta durante la THS.
- Este riesgo relativo no depende de la edad ni de la duración del tratamiento, pero dado que el riesgo inicial está muy estrechamente relacionado con la edad, el riesgo global de accidente cerebrovascular en mujeres que utilizan THS aumentará con la edad (ver sección 4.4).

**Estudios WHI combinados: riesgo adicional de accidente cerebrovascular isquémico\*4 durante 5 años de uso**

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)
Se han notificado otras reacciones adversas relacionadas con el tratamiento con estrógenos-progestágenos.

    - *Enfermedad de la vesícula biliar.*
- *Trastornos de la piel y del tejido subcutáneo: cloasma, eritema multiforme, eritema nudoso, púrpura vascular.*
- *Demencia probable después de los 65 años (ver sección 4.4).*

Notificación de sospechas de reacciones adversas

Es importante notificar sospechas de reacciones adversas al medicamento tras su autorización. Ello permite una supervisión continuada de la relación beneficio/riesgo del medicamento. Se invita a los profesionales sanitarios a notificar la sospecha de reacciones adversas a través del Sistema Español de Farmacovigilancia de Medicamentos de Uso Humano: www.notificaRAM.es.