guan-wang/ReDis-QA huggingface dataset:
Question: Osteonecrosis of femoral head seen in -a) Sickle cell diseaseb) Gaucher's diseasec) Polycythemiad) Hyperparathyroidisme) Fracture
A. bcde
B. abcd
C. acde
D. abce
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Osteonecrosis
Question: Osteopetrosis is also known as:
A. Albers Schonberg disease
B. Marble bone disease
C. Fragilis generalisata
D. All of the above
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Osteopetrosis
Question: Osteosarcoma can arise from:
A. Diaphysis
B. Epiphysis
C. Metaphysis
D. All of the above
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Osteosarcoma
Question: Age group affected by Osteosarcoma
A. Up-to 10 yrs
B. 10 -20 yrs
C. 30-40 yrs
D. Older than 45 yrs
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Osteosarcoma
Question: Which of the following is not true in relation to Osteosarcoma?
A. Paget's disease & prior irradiation are factors
B. Rb gene mutation is associated with hereditary variant
C. c-myc gene implicated in the genesis
D. Codman's triangle is the characteristic x-ray finding
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Osteosarcoma
Question: Osteosarcoma of the jaw:
A. Occurs mostly in the maxilla
B. Seen in old age
C. Highly malignant tumour which shows early metastasis
D. Shows a soap bubble type of radiolucency in radiographs
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Osteosarcoma
Question: Osteosarcoma originates from which type of cells
A. Osteocytes
B. Osteoblasts
C. Chondrocytes
D. Osteoclast
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Osteosarcoma
Question: Trigger finger occurs in -a) Rheumatoid athritisb) Traumac) Osteosarcomad) Osteoarthritis
A. ac
B. ab
C. ad
D. bc
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Osteosarcoma
Question: Regarding Osteosarcoma which one is true
A. Affects people in 5th or 6th decade
B. Occurs due to proliferation of osteoclast
C. Lymphatic metastasis is most common
D. Sunray appearance indicates new bone-formation
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Osteosarcoma
Question: A child is diagnosed with Osteosarcoma based on Sunray appearance seen on x-ray. This is because of
A. Calcification along the periosteum
B. Calcification along the blood vessels
C. Perosteal reaction
D. Soft tissue invasion
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Osteosarcoma
Question: Which of the following investigations is not required in Osteosarcoma?
A. MRI
B. Bone marrow biopsy
C. CT chest
D. Bone scan
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Osteosarcoma
Question: Not true about Osteosarcoma
A. Associated with Hyperglycemia
B. Sun burst appearance on x-ray
C. Pulsatile bone tumor
D. Osteitis imperfecta has increased risk of transforming into osteosarcoma
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Osteosarcoma
Question: In treatment of Osteosarcoma all of the following are used except (REPEAT)
A. High dose Methotrexate
B. Cycloohosphamide
C. Vincristine
D. Doxorubicin
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Osteosarcoma
Question: Most common site of metastases in case of Osteosarcoma DELETE
A. Brain
B. Lungs
C. Liver
D. Bladder
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Osteosarcoma
Question: X ray appearance of Osteosarcoma are all except
A. Perosteal reaction
B. Codmnans triangle
C. Soap bubble
D. Sun ray appearance
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Osteosarcoma
Question: Osteosarcoma is differentiated from myositis ossificans by radiology by:
A. Location
B. Absence of osteomyelitic changes
C. Shape of swelling
D. Peripheral field of differentiation
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Osteosarcoma
Question: Dense calcification is found in -a) Osteosarcomab) Chondroblastomac) Synovial sarcomad) Osteoblastoma
A. abd
B. bcd
C. abc
D. ab
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Osteosarcoma
Question: Which carcinoma metastases to heart?a)  Ca breastb) Ca stomach c)  Ca lungd)  Ca urinary bladder  e) Osteosarcoma
A. a
B. bc
C. ac
D. b
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Osteosarcoma
Question: Sun ray appearance is seen in – a) Osteosarcomab) Ewing sarcomac) Osteoclastomad) Multiple myeloma
A. ac
B. ab
C. ad
D. bc
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Osteosarcoma
Question: Average time interval between radiation exposure and genesis of post radiation Osteosarcoma
A. 2 yrs
B. 4 yrs
C. 8 yrs
D. 16 yrs
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Osteosarcoma
Question: A 15 year old boy presents was brought to OPD with a history of pain and swelling in the right thigh. Biopsy of the mass demonstrates Osteosarcoma. His mother was diagnosed with breast cancer 1 year ago and his maternal grandmother died of the breast cancer 10 years ago. The child has 3 younger siblings. Siblings are at an increased risk of developing which of the following cancer ?
A. Wilms
B. Neuroblastoma
C. Hepatoblastoma
D. Glioma
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Osteosarcoma
Question: Osteosarcoma characteristically may develop in some cases of
A. Osteopetrosis
B. Osteogenesis irnperfecta
C. Acromegaly
D. Osteitis deformans
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Osteosarcoma
Question: Bone forming tumors are -a) Osteosarcomab) Osteoid osteomac) Giant cell tumourd) Osteoblastomae) Chondrosarcoma
A. abd
B. bcd
C. abc
D. ab
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Osteosarcoma
Question: Lymph node metastasis is common in   a) Osteosarcoma  b) Fibrous histiocytoma  c) Angiosarcoma  d) Rhabdomyosarcoma
A. abc
B. acd
C. cd
D. bd
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Osteosarcoma
Question: Osteosarcoma can develop in:
A. Osteoid osteoma
B. Osteoblastoma
C. Paget's disease
D. All of the above
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Osteosarcoma
Question: Osteosarcoma commonly affects: September 2005
A. Metaphysis
B. Diaphysis
C. Epiphysis
D. None of the above
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Osteosarcoma
Question: A 35-year-old female presented to the medicine OPD with paresthesias and weakness of B/L lower limbs with a band like sensation of tightness around the torso along with painful loss of vision in both eyes along with diplopia and periorbital pain. There is a history of similar attacks in the past with period of normalcy in between O/E, Ataxia- present Papillitis (on fundus examination) Facial myokymia Bladder incontinence and constipation CSF studies revealed mononuclear cell pleocytosis along with increased IgG. Which of the following are the oral drugs approved for the above condition: - 1. Fingolimod 2. Natalizumab 3. Teriflunomide 4. Glatiramer acetate
A. Only 1
B. Both 1 and 3
C. 1,2 and 3
D. All of the above
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Papillitis
Question: Mutation of which of the following gene is most impoant in Paroxysmal Nocturnal Hemoglobinuria
A. Decay accelerating factor (DAF)
B. Membrane inhibitor of reactive lysis (MIRL)
C. Glycosyl phosphatidyl inositol (GPI)
D. CD8 binding protein
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Paroxysmal Nocturnal Hemoglobinuria
Question: The gold standard Lab test for diagnosis of PNH (Paroxysmal Nocturnal Hemoglobinuria) is?
A. Ham test
B. Haptoglobin
C. Flow cytometry
D. Sucrose Lysis test
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Paroxysmal Nocturnal Hemoglobinuria
Question: Which of the following is NOT seen in Paroxysmal Nocturnal Hemoglobinuria -
A. Hypocellular bone marrow
B. Hemosiderinuria
C. Increased LAP score
D. Pancytopenia
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Paroxysmal Nocturnal Hemoglobinuria
Question: Which of the following is NOT seen in Paroxysmal Nocturnal Hemoglobinuria :
A. Thrombosis
B. Hemosiderinuria
C. Decreased LDH
D. Thrombocytopenia
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Paroxysmal Nocturnal Hemoglobinuria
Question: True about Pendred Syndrome
A. Blindness
B. Conductive deafness
C. Sensorineural deafness
D. All of the above
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Pendred Syndrome
Question: All are features of Pertussis except –
A. Encephalopathy
B. Cerebellar Ataxia
C. Subconjunctival hemorrhage
D. Bronchiectasis
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Pertussis
Question: Pertussis vaccine side effect -
A. Local pain
B. Excessive cry
C. Fever
D. All of above
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Pertussis
Question: Which toxin acts by ADP ribosylation-a) Botulinum toxinb)  Shiga toxinc) V.cholerae toxin d) Diphtheria toxine) Pertussis toxin
A. cde
B. acd
C. bde
D. ade
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Pertussis
Question: True about Pertussis is/are -a) Incubation period is 7-14 daysb) Main source of infection is chronic carriersc) Can affect any aged) Secondary attack rate in unimmunised persons is 90%e) More common in summers
A. abc
B. acd
C. bc
D. bde
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Pertussis
Question: Phenylketonuria caused by deficiency of
A. Tyrosine transaminase
B. Tyrosine hydroxylase
C. Phenylalanine hydroxylase
D. Phenylketonuria hydroxylase
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Phenylketonuria
Question: In Phenylketonuria the main aim of first line therapy is:
A. Replacement of the defective enzyme
B. Replacement of the deficient product
C. Limiting the substrate for deficient enzyme
D. Giving the missing amino acid by diet
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Phenylketonuria
Question: In Phenylketonuria, the first line therapy is:
A. Replacement of the defective enzyme
B. Replacement of the deficient product
C. Limiting the substrate for deficient enzyme
D. Giving the missing amino acid by diet
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Phenylketonuria
Question: Phenylketonuria is due to deficiency of:
A. Phenylalanine
B. Phenylalanine hydroxylase (PAH)
C. Galactokinase
D. Tyrosinase
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Phenylketonuria
Question: Child born to mothers with Phenylketonuria will have all except
A. Mental retardation
B. Macrocephaly
C. Growth retardation
D. Congenital heart disease
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Phenylketonuria
Question: Phenylketonuria is due to the deficiency of:
A. Phenylalanine
B. Phenylalanine hydroxylase (PAH)
C. Phenylene
D. All of these
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Phenylketonuria
Question: In Phenylketonuria the main aim of first-line therapy is
A. Replacement of the defective enzymes
B. Replacement of the deficient product
C. Limiting the substrate for deficient enzyme
D. Giving the missing amino acid by diet
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Phenylketonuria
Question: Which one of the following is not a feature of Phenylketonuria ?
A. Severe mental retardation
B. Reduced tendon reflexes
C. Enamel hypoplasia
D. Vomiting in early infancy
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Phenylketonuria
Question: True about Rx of Phenylketonuria
A. Limiting the substrate for deficient enzyme
B. Giving the missing amino acids by diet
C. Gene therapy can be successfully used
D. Child should refrain from milk.
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Phenylketonuria
Question: Which of the following is not a feature of Phenylketonuria?
A. Severe mental retardation
B. Reduced tendon reflexes
C. Hypopigmentation in skin
D. Hair loss
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Phenylketonuria
Question: Phenylketonuria is -
A. AD
B. AR
C. X linked dominant
D. X linked recessive
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Phenylketonuria
Question: Which of the following is a feature of Phenylketonuria?
A. Loss of deep tendon reflexes
B. Mental retardation
C. Macrocephaly
D. All
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Phenylketonuria
Question: Phenylketonuria is caused by deficiency of
A. Tyrosine transminase
B. Tyrosine hydroxylase
C. Phenylalanine transaminase
D. Phenylalanine hydroxylase
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Phenylketonuria
Question: Phenylketonuria I is due to deficiency of -
A. Phenylalanine hydroxylase
B. Homogentisate oxidase
C. Tyrosinase
D. None
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Phenylketonuria
Question: Phenylketonuria is due to deficiency of -
A. Phenylalanine transaminase
B. Phenylalanine hydroxylase
C. Tyrosine transaminase
D. Tyrosine hydroxylase
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Phenylketonuria
Question: True statement regarding a 3-week old child with Phenylketonuria is all, except –
A. Provocative protein meal tests helps in the diagnosis
B. Tyrosine becomes an Essential amino–acid in diet
C. Serum Phenylalanine is increased and urinary Phenyl Pyruvate level is elevated
D. Phenylalanine should be completely stopped in diet
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Phenylketonuria
Question: Phenylketonuria is detected by which urine test:
A. Guthrie test
B. Sodium nitroprusside test
C. Blot test
D. FeCl3
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Phenylketonuria
Question: Boiled cabbage or rancid butter smelling urine is seen in Phenylketonuria
A. Tyrosinemia
B. Isovaleric Acidaemia
C. Multiple carboxylase deficiency
D. Phenylketonuria
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Phenylketonuria
Question: Phenylketonuria is ?
A. AD
B. AR
C. X linked dominant
D. X linked recessive
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Phenylketonuria
Question: Which one of the following is not a feature of Phenylketonuria?
A. Severe mental retardation
B. Reduced tendon reflexes
C. Enamel hypoplasia
D. Vomiting in early infancy
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Phenylketonuria
Question: Enzyme defect in Classic Phenylketonuria
A. Phenylalanine hydroxylase
B. Dihydrobiopterin reductase
C. Fumarylacetoacetate hydrolase
D. Homogentisate oxidase
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Phenylketonuria
Question: Which of the following disorder of mother leads to microcephaly in baby –a)  SLEb)  Hepatitis A c) Phenylketonuriad)  Rubella
A. ab
B. cd
C. bd
D. ac
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Phenylketonuria, Rubella
Question: Pierre Robin Sequence includes
A. Glossoptosis
B. Airway obstructions
C. Cleft lip
D. Micrognathia
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Pierre Robin Sequence
Question: Regarding syphilis, all are true, except -a) VDRL titre decreases or even absent after treatmentb) VDRL becomes positive after 10-14 days of infectionc) Earliest serological test to become positive in untreated primary syphilis is TPHAd) Yaws and Pinta cannot be differentiated
A. bc
B. c
C. ac
D. ad
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Pinta, Yaws
Question: Pinta is caused by:
A. Treponema peenue
B. Treponema carateum
C. Treponema pallidum
D. Treponema endemicum
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Pinta
Question: Pinta is caused by
A. Treponema peenue
B. Treponema cerateum
C. Treponema pallidum
D. Treponema endemicum
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Pinta
Question: Pinta disease is caused by
A. Treponema pallidum
B. Treponema carateum
C. Leptospira interrogans
D. None of the above
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Pinta
Question: Which is a noveneral form of trephonemal infection – a) Yawsb) Pintac) Syphillisd) GV
A. ab
B. a
C. ad
D. bc
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Pinta, Yaws
Question: Pityriasis Rosea, true is:
A. Self-limiting
B. Chronic relapsing
C. Life threatening infection
D. Caused by dermatophytes
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Pityriasis Rosea
Question: The following statement is TRUE for Pityriasis Rosea:
A. Self limiting
B. Chronic relapsing
C. Life threatening infection
D. Caused by dermatophytes
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Pityriasis Rosea
Question: Plague epidemic in Surat in 1995 has occurred after a 'silence period' of
A. 18 years
B. 23 years
C. 28 years
D. 30 years
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Plague
Question: Vectors for Plague transmission
A. X. cheopis
B. X. astia
C. Pulex irritans
D. All of the above
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Plague
Question: Plague is transmitted by the bite of
A. Rat flea
B. Culex mosquito
C. Body louse
D. Tse-Tse fly
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Plague
Question: Plague is transmitted through:-
A. Tick
B. Mite
C. Flea
D. Mosquito
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Plague
Question: Plague is what type of zoonosis?
A. Cyclozoonosis
B. Direct zoonosis
C. Sapro-zoonosis
D. Meta Zoonosis
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Plague
Question: Plague is transmitted by the bite of -
A. Culex mosquito
B. Rat flea
C. Body louse
D. Tse-Tse fly
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Plague
Question: Chronic fibrosing mediastinitis is seen ina) Tuberculosisb) Histoplasmosisc) Plagued) Sarcoidosis
A. acd
B. bcd
C. abc
D. abd
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Plague, Tuberculosis
Question: Indicator for the outbreak of Plague epidemic is
A. Rat burrow index
B. Total flea
C. Specific flea index
D. Cheopis index
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Plague
Question: Plague is transmitted by -
A. Mite
B. Flea
C. Sand fly
D. None
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Plague
Question: Plague is transmitted by all EXCEPT?
A. X. Cheopsis
B. X. Astia
C. Pulexirritans
D. Culex
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Plague
Question: Indicator for outbreak of Plague epidemic is
A. Rat burrow index
B. Total flea
C. Specific flea index
D. Cheopis index
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Plague
Question: Drug of choice for Pneumocystis Pneumonia
A. Cotrimoxazole
B. Penicillin
C. Itraconazole
D. Ivermectin
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Pneumocystis Pneumonia
Question: POEMS Syndrome includes all, EXCEPT:
A. Polyneuropathy
B. Organomegaly
C. Endocrinopathy
D. Multiple sclerosis
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: POEMS Syndrome
Question: Poland Syndrome is
A. Congenital absence of Pectoralis minor
B. Acquired Weakness and disuse atrophy of Pectoralis minor
C. Acquired Weakness and disuse atrophy of Pectoralis major
D. Congenital absence of Pectoralis major
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Poland Syndrome
Question: What is the characterstic of Poland Syndrome ?
A. Amastia with the absence of the Pectoralis major
B. Athelia with the absence of the Pectoralis major
C. Amastia with the absence of the Pectoralis minor
D. Athelia with the absence of the Pectoralis minor
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Poland Syndrome
Question: Polyarteritis Nodosa (PAN) typically involves which of the following?
A. Large elastic arteries
B. Small- or medium-sized muscular arteries
C. Arterioles
D. Capillaries
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Polyarteritis Nodosa
Question: Polycythemia Vera is characterized by all, EXCEPT:
A. Bleeding
B. Increased viscosity of blood
C. Splenomegaly
D. None of the above
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Polycythemia Vera
Question: A 59-year-old male came with Hb 18.0 gm/dl on three occasions. The resident doctor wants to exclude Polycythemia Vera. Which of the following is the most relevant investigation -
A. Hematocrit
B. Total leukocyte count
C. Red cell mass
D. Reticulocyte count
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Polycythemia Vera
Question: A 59-year-old male came with Hb 18.0 gm/dl on three occasions. The resident doctor wants to exclude Polycythemia Vera. Which of the following is the most relevant investigation :
A. Hematocrit
B. Total leukocyte count
C. Red cell mass
D. Reticulocyte count
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Polycythemia Vera
Question: Which is not seen in Polycythemia Vera?
A. Ocular congestion
B. Increase RBC count
C. Increase erythropoietin level
D. Increased Vit B12 binding capacity
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Polycythemia Vera
Question: Primary Hyperoxaluria occurs due to defect in metabolism of
A. Cystein
B. Tryptophan
C. Tyrosine
D. Glycine
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Primary Hyperoxaluria
Question: Primary Hyperoxaluria occurs in defect in metabolism of
A. Cystein
B. Tryptophan
C. Tyrosine
D. Glycine
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Primary Hyperoxaluria
Question: Primary Hyperparathyroidism is associated with -
A. Increased serum PTH and Hypercalcemia
B. Decreased serum PTH and Hypercalcemia
C. Increased serum PTH and Hyporcalcemia
D. Decreased serum PTH and Hyporcalcemia
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Primary Hyperparathyroidism
Question: Which level of Prolactin definitely suggest Prolactinoma?
A. >50 mg/L
B. >100 mg/L
C. >150 mg/L
D. >200 mg/L
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Prolactinoma
Question: Prolactinoma in pregnancy, all are true except
A. Most common pituitary tumor but rarely symptomatic
B. Increase in prolactin levels worse prognosis
C. Macroadenoma> 1 cm is associated with bad prognosis
D. Regular visual checkup
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Prolactinoma
Question: Which of the following is true about pituitary adenomaa) Accounts for 10% of brain tumorsb) Erodes the sellar and extends into surrounding areac) Prolactinoma is least commond) It is differentiated by reticulin stain
A. acd
B. abd
C. abc
D. ab
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Prolactinoma
Question: Prolactinoma in pregnancy, all are true except -
A. Most common pituitary tumor but rarely symptomatic
B. Increase in prolactin levels worse prognosis
C. Macroadenoma > 1 cm is associated with bad prognosis
D. Regular visual checkup
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Prolactinoma
Question: Which of the following is true about pituitary tumor?a) It is present in 10% of brain tumors b) Erodes the sella and extends into surrounding areac) Prolactinoma is least commond) It is differentiated by reticulin stain
A. acd
B. abd
C. abc
D. ab
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Prolactinoma
Question: Prolactinoma in pregnancy, all are true except:
A. Most common pituitary tumor but rarely symptomatic
B. Increase in prolactin levels worse prognosis
C. Macroadenoma> 1 cm is associated with bad prognosis
D. Regular visual checkup
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Prolactinoma
Question: All of the following statements about Pseudohypoparathyroidism are true, except -
A. ↓Serum PTH
B. ↓ Serum calcium
C. ↑ Serum phosphate
D. Albright's hereditary osteodystrophy
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Pseudohypoparathyroidism
Question: A young patient presented with HTN and VMA 14 mg/24, the causes is/are -a) Medullary carcinoma thyroidb) Von Hippel Lindau syndromec) Graves diseased) Pseudohypoparathyroidisme) Sturge weber syndrome
A. abc
B. bcd
C. cde
D. abe
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Pseudohypoparathyroidism
Question: All of the following statements about Pseudohypoparathyroidism are true, except:
A. Low Serum PTH
B. Low Serum calcium
C. High Serum Phosphate
D. Albreight's Hereditary osteodystrophy
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Pseudohypoparathyroidism
Question: Pseudohypoparathyroidism is characterized by:
A. Normal serum Ca++ and decreased serum PTH
B. Decreased serum Ca++ and decreased serum PTH
C. Decreased serum Ca++ and Increased serum PTH
D. Normal serum Ca++ and Increased serum PTH
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Pseudohypoparathyroidism
Question: Most common cause of Pseudomyxoma Peritonei is
A. Mucinous tumour of appendix
B. Ovarian tumour
C. Colorectal carcinoma
D. None of the above
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Pseudomyxoma Peritonei
Question: Q fever is caused by -
A. Pseudomonas
B. Francisella
C. Coxiella burnetii
D. Rickettsia typhi
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Q fever
Question: Q fever is caused by-
A. R Quintana
B. C. burnetii
C. R typhi
D. R akari
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Q fever
Question: Q fever is transmitted by -
A. Ticks
B. Mites
C. Louse
D. Flea
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Q fever
Question: All of the following statement are true regarding Q fever except-
A. it is zoonotic disease
B. Human disease is characterized by an interstitial pneumonia
C. No rash is seen
D. Weil felix reaction is very useful for diagnosis
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Q fever
Question: Q fever is caused by?
A. Rickettsia typhi
B. Rochalimea Quintana
C. Coxiella burnetii
D. Rickettsia ricketssi
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Q fever
Question: All of the following statement are true regarding Q fever except -
A. It is zoonotic disease
B. Human disease is characterized by an interstitial pneumonia
C. No rash is seen
D. Weil-felix reaction is very useful for diagnosis
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Q fever
Question: True about Q fever -
A. Rash on palms and soles, headache and fever are common symptoms
B. Transmitted by human body louse
C. Inhaled acrosols spread the infection
D. Mosquito bite prevention is impoant in prevention
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Q fever
Question: Which of the following statement about Q fever is false-
A. Highly infectious zoonotic disease
B. The mode of transmission is by inhalation
C. Ahropods are involved in its transmission to man
D. There is no rash or local lesion
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Q fever
Question: Mode of transmisstion of Q fever -
A. Bite of infected louse
B. Bite of infected tick
C. Inhalation of aerosol
D. Bite of infected mice
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Q fever
Question: All of following statements are true regarding Q fever except.
A. It is a zoonotic infection.
B. Human disease is characterized by an interstitial pneumonia
C. No rash is seen
D. Weil Felix reaction is very useful for diagnosis.
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Q fever
Question: Mode of transmission of Q fever is
A. Bite of infected louse
B. Bite of infected tick
C. Bite of infected mite
D. Inhalation of aerosol
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Q fever
Question: Mode of transmission of Q fever is -
A. Bite of infected louse
B. Bite of infected tick
C. Inhalation of aerosol
D. Bite of infected mite
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Q fever
Question: Which of the following characterizes Q fever?
A. Has an incubation period of four to six weeks
B. is an acute febrile illness caused by Coxiella Burnetii
C. Is an illness confined to the upper respiratory tract
D. Is most commonly found in tropical region
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Q fever
Question: Q fever is caused by which Rickettsial Agent
A. R. prowazekii
B. R. tsutsugamushi
C. C. burnetii
D. Rochalimaea quintana
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Q fever
Question: Serological diagnosis is made in -a) Actinomycosis b) T.B.c) Syphilisd) Gonorrhoeae) Q fever
A. abd
B. acd
C. cde
D. ade
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Q fever
Question: False about Q fever
A. Causative agent is Coxiella burnetii
B. Incubation period is 2-3 weeks
C. Vector is louse
D. Mode of transmission is inhalation of infected dust
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Q fever
Question: All of the following statements are true regarding Q fever except:
A. It is a zoonotic disease
B. Human disease is characterized by an interstitial pneumonia
C. No rash is seen
D. Weil-Felix reactions is very useful for diagnosis
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Q fever
Question: Mode of transmission of Q fever:
A. Ticks
B. Mites
C. Aerosols
D. Mosquito
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Q fever
Question: All of the following statement are true regarding Q fever except:
A. It is a zoonotic disease
B. Human disease is characterized by an interstitial pneumonia
C. No rash is seen
D. Weil Felix reactions is very useful for diagnosis
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Q fever
Question: Which of the following statements about Q fever is false -
A. Highly infectious zoonotic disease
B. The mode of transmission is by inhalation
C. Arthropods are involved in its transmission to man
D. There is no rash or local lesion
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Q fever
Question: Which among the following country is a 'Rabies free country'?
A. USA
B. Russia
C. Australia
D. France
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Rabies
Question: True about Rabies  a) Bats Transmit disease in some parts of the world  b) Brainstem encephalitis is characteristic c)  Negri bodies commonly found in thalamus and anterior pituitary  d) Paraesthesia is not seen  e) Recovery is the usual course
A. ab
B. abc
C. abd
D. bcd
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Rabies
Question: Rabies vaccine schedule is:
A. 0,3,7,14,28
B. 8,0,4,0,1,1
C. 8,0,0,4,1,1
D. 8,0,4,0,0,1
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Dose of Rabies immunoglobulin is?
A. 10 IU/Kg body weight
B. 15 IU/kg body weight
C. 20 IU/kg body weight
D. 25 IU/kg body weight
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Rabies
Question: Rabies virus is inactivated by
A. Phenol
B. UV radiation
C. BPL
D. All
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: In the Rabies vaccine schedule of 0,3,7,14,30,90,0 means -
A. Day of dog bite
B. Day of first injection
C. Day of symptom onset
D. Day of dog death
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Negri bodies are hallmark of Rabies, these Negri bodies are seen in?
A. Neurons
B. Microglia
C. Astrocytes
D. Oligodendroglia
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Rabies
Question: Negri bodies, which are pathognomonic of Rabies, are commonly found in which of the following cells?
A. Anterior horn motor neurons of the spinal cord
B. Purkinje cells of the cerebellum
C. Microglial cells
D. Ependymal lining cells
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Rabies in not found in
A. Lakshadweep Islands
B. Rajasthan
C. Meghalaya
D. Orrisa
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Rabies
Question: Which of the following statements is TRUE about Rabies Virus:
A. It is double stranded RNA virus
B. Contains a DNA-dependent RNA polymerase
C. Negative sense RNA Genome
D. Affects motor neurons
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Rabies
Question: Rabies free country is:
A. China
B. Russia
C. Australia
D. France
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Rabies
Question: A 4-year-old child comes to you with a history of dog bite from a street dog. This child had already received Rabies vaccine last year (full course). What will be your next course of action with regard to immunization:
A. Repeat the entire schedule of Rabies vaccine
B. No further dosages of Rabies vaccines required
C. Two booster doses at day 0 and day 3
D. Two booster dosages at day 0 and day 14
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Rabies
Question: Rabies can be confirmed in patients early in illness by: March 2013 (b, e)
A. Antigen detection by corneal smears immunofluorescence
B. Antigen detection by immunofluorescence of skin biopsy
C. Demonstration of neutralizing antibodies
D. Demonstration of Negri bodies in hippocampus
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Cell culture Rabies vaccine is given at: September 2005
A. Medial pa of thigh
B. Deltoid muscle
C. Anterior Abdomen
D. Lateral pa of thigh
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Rabies vaccine is prepared from:-
A. Street viral strain
B. Fixed viral strain
C. Wild viral strain
D. Any of the above
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: In Rabies, the characteristic pathological manifestation is -
A. Ventriculitis
B. Encephalitis
C. Basal ganglia affection
D. Meningitis
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Rabies free country is
A. China
B. Australia
C. France
D. Russia
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Incubation period of Rabies depends on:
A. Severity of bite
B. Number of bite
C. Site of bite
D. All of the above.
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: Neurological complications following Rabies vaccine is common with -
A. HDCS Vaccine
B. Chick embryo Vaccine
C. Semple Vaccine
D. Duck Egg Vaccine
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Rabies
Question: Which of the following is NOT seen in furious Rabies -
A. Hyperexcitability
B. Aerophobia
C. Hypertension
D. Constriction of pupil
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: Rabies can be transmitted by all EXCEPT: March 2013 (d)
A. Bite of rabid dog
B. Bite of bats
C. Bite of fox
D. Bite of squirrel
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: Rabies virus
A. Cytotropic
B. Dermatotropic
C. Chromophilic
D. Neurotropic
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: Rabies vaccine Pre exposure prophylaxis schedule is:
A. 0,3,7
B. 0,7,28
C. 0,3,7,28
D. 0,3,7,21,28
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Incubation period of Rabies depends on: September 2010
A. Number of bites
B. Site of bite
C. Animal species
D. All of the above
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: Rabies vaccine is prepared from:
A. Liver virus
B. Street virus
C. Fixed virus
D. None of the above.
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Rabies
Question: Select false statement regarding Rabies infection Rabies is dead end infection in man Can be transmitted by aerosols Suturing is usually recommended on local wound Human Rabies immunoglobulin dose - 10 IU/kg Human bite can transmit Rabies infection
A. 2, 3, 4, 5
B. 2, 3, 4
C. 4, 5
D. 3, 4, 5
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: Regarding Rabies, true is -
A. Incubation period depends on the site of bite
B. Diagnosis is by eosinophilic intranuclear inclusion
C. It is a RNA virus
D. Caused only by dogs
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Rabies
Question: Which of the following is diagnostic of Rabies?
A. Guarneri bodies
B. Negri bodies
C. Cowdry A body
D. Bollinger bodies
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Which of the following inclusion body is seen in a patient with Rabies?
A. Cowdry-B
B. Negri bodies
C. Guarneri bodies
D. Bollinger bodies
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Pre-exposure prophylaxis for Rabies is given on
A. Days 0, 3, 7, 14, 28, 90
B. Days 0, 3, 7, 28, 90
C. Days 0, 3
D. Days 0, 7, 28
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: Nervous tissue Rabies vaccines are usually manufactured from
A. Duck embryos
B. Human diploid cell
C. Sheep
D. Chick embryos
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Rabies
Question: Rapid diagnosis of Rabies in a Rabid living dog is by?
A. Fluorescent antibody test
B. Corneal impression
C. Inoculation in mouse
D. None of the above
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Rabies
Question: Rabies vaccine was first developed by ?
A. Robe Koch
B. Louis Pasteur
C. Edward Jenner
D. Loeffler
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Diagnostic of Rabies -
A. Guameri bodies
B. Negri bodies
C. Cowdry A body
D. Bollinger bodies
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Rabies virus is inactivated by -
A. Phenol
B. UV radiation
C. BPL
D. ALL
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: In Rabies, the characterstic pathological manifestation is -
A. Ventriculitis
B. Brainstem encephalitis
C. Basal ganglia affection
D. Meningitis
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Rabies is diagnosed by ?
A. Hair follicle smear
B. Corneal smear
C. Isolation from blood
D. Nerve biopsy
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Most common type of pathological changes seen in Rabies are
A. Meningitis
B. Cranial aeritis
C. Ventriculitis
D. Brain stem encephalitis
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: Neurological complications following Rabies vaccine is common with ?
A. HDCS Vaccine
B. Chick embryo Vaccine
C. Semple Vaccine
D. Duck Egg Vaccine
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Rabies
Question: Which of the following is not a route of transmission Rabies?
A. Bite
B. Lick
C. Aerosol
D. Ingestion
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: Rabies vaccine for pre exposure prophylaxis is given at?
A. 0, 3, 7 days
B. 0, 3, 7, 14 days
C. 0, 3, 7, 14, 30 days
D. 0, 7, 28 days
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: Dose of Human Rabies Immunoglobulin is:
A. 10 IU/kg
B. 20 IU/kg
C. 30 IU/kg
D. 40 IU/kg
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Rabies can be transmitted by all the following routes except -
A. Aerosol
B. Bites
C. Ingestion
D. Ingestion
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Rabies
Question: Rabies vaccine was first developed by -
A. Robert Koch
B. Louis Pasteur
C. Edward Jenner
D. Loeffler
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Intramuscular Rabies vaccine Post exposure prophylaxis schedule is
A. 1-1-0-1-1
B. 1-1-1-1-1
C. 2-2-2-0-2
D. 8-0-4-0-0-4
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: In a patient suspected to be diagnosed with Rabies, a sample of corneal smear was taken. Which of the following investigations can be done from the specimen?
A. RT PCR
B. Immunofluorescence test
C. Negri body visualization
D. Virus isolation
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: Case Fatality Rate (CFR) of Rabies is
A. 80%
B. 90%
C. 100%
D. 95%
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Rabies
Question: Rabies is identified by -
A. Guarnieri bodies
B. Negri bodies
C. Cowdry A bodies
D. Cowdry B bodies
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Rabies
Question: All are true regarding Rabies virus, except?
A. Single Stranded RNA virus
B. Linear
C. Negative sense
D. Space vehicle shaped
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: A child has received full Rabies vaccination in December 2018 and now presented with oozing wound on Great toe and the pet had vaccination also. Next line of management is
A. No vaccine required
B. RIG + 5 doses of vaccine
C. 5 doses of vaccines only
D. 2 doses of Rabies vaccine
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Rabies
Question: Rabies vaccine not to be given in case of?
A. Rat bite
B. Cat bite
C. Dog bite
D. Monkey bite
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Rabies
Question: Which of the following treatment is done for Juvenile Onset Recurrent Respiratory Papillomatosis:
A. Bevacizumab
B. Aerosol Cidofovir
C. Interferon Beta
D. Steroids
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Recurrent Respiratory Papillomatosis
Question: Commonest metastasis in Renal Cell Carcinoma is to
A. Lung
B. Bone
C. Adrenal
D. Liver
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Renal Cell Carcinoma
Question: Chromophilic Renal Cell Carcinoma is associated with
A. 3p
B. Trisomy 7 and 17
C. 6q
D. t(3, 11)
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Renal Cell Carcinoma
Question: Which of the following statement about Renal Cell Carcinoma (Hypemephroma) is false:
A. Originate in the coex
B. Histologically are usually Adenocarcinomas
C. May present with varicocele
D. Radiosensitive
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Renal Cell Carcinoma
Question: Which of the following is true regarding Renal Cell Carcinoma?
A. More common in males
B. May cause varicocele
C. May invade the renal vein
D. All the above
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Renal Cell Carcinoma
Question: Which of the following is not true regarding Renal Cell Carcinoma?
A. More common in males
B. Has a tendency to invade the renal vessels
C. Usually situated near the poles
D. Hematuria is not a feature
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Renal Cell Carcinoma
Question: What is not a part of triad of Renal Cell Carcinoma?
A. Loin Mass
B. Hematuria
C. Loin Pain
D. Oliguria
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Renal Cell Carcinoma
Question: Retinitis Pigmentosa is associated with all except –
A. Usher Syndrome
B. Marfan's Syndrome
C. Kearns – Sayre Syndrome
D. Bassen – Kornzweig Syndrome
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Retinitis Pigmentosa
Question: Retinitis Pigmentosa is associated with all except -
A. Usher Syndrome
B. Marfan's Syndrome
C. Kearns- Sayre Syndrome
D. Bussen - Kornzweig Syndrome
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Retinitis Pigmentosa
Question: Retinitis Pigmentosa is associated with all except:
A. Usher Syndrome
B. Marfan's Syndrome
C. Kearns- Sayre Syndrome
D. Bassen - Kornzweig Syndrome
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Retinitis Pigmentosa
Question: Retinoblastoma gene is located on –
A. Chromosome 5
B. Chromosome 8
C. Chromosome 13
D. Chromosome 16
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Retinoblastoma
Question: Retinoblastoma is bilateral in:
A. 1% of cases
B. 50% of cases
C. 100% of cases
D. 30% of cases
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Retinoblastoma
Question: Second common malignancy in Patients of Retinoblastoma is:
A. Osteoblastoma
B. Osteochondroma
C. Osteoclastoma
D. Osteosarcoma
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Retinoblastoma
Question: Retinoblastoma is seen in -
A. Children
B. Adults
C. Old age
D. At any age
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Retinoblastoma
Question: Retinoblastoma gene is located on -
A. Chromosome 5
B. Chromosome 8
C. Chromosome 13
D. Chromosome 16
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Retinoblastoma
Question: Retinoblastoma arises from
A. Layer of rods & cones
B. Layer of bipolar cells
C. External limiting membrane
D. Any nucleated retinal layer
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Retinoblastoma
Question: Retinoblastomas arising in the context of germ-line mutations not only may be bilateral, but also may be associated with______ (so called "trilateral" retinoblastoma)
A. Medulloblastoma
B. Pinealoblastoma
C. Neuroblastoma
D. Hemangioblastoma
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Retinoblastoma
Question: Chemotherapy agents used for Retinoblastoma includes
A. Vincristine, Etoposide, Carboplatin
B. Vincristine, Doxorubicin, Carboplatin
C. Doxorubicin, Etoposide, Carboplatin
D. Actinomycin, Doxorubicin, Carboplatin
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Retinoblastoma
Question: Pseudoglioma differs from Retinoblastoma in that pseudoglioma is associated with –
A. Decreased intraocular pressure
B. Blurring of vision
C. Enlargement of the optic foramen
D. All of the above
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Retinoblastoma
Question: A patient with known mutation in the `RB gene' is `disease free' from Retinoblastoma. The patient is at highest risk of developing which of the following malignancies –
A. Renal cell carcinoma
B. Osteosarcoma
C. Pinealoblastoma
D. Chondrosarcoma
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Retinoblastoma
Question: Most common secondary tumor with Retinoblastoma is
A. Neuroblastoma
B. Pineoblastoma
C. Osteochondroma
D. Osteosarcoma
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Retinoblastoma
Question: Retinoblastoma is associated with-
A. Osteosarcoma
B. Hepatocellular
C. SCC
D. Osteoclastoma
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Retinoblastoma
Question: A patient with known mutation in the 'Rb gene' is 'disease free' from Retinoblastoma. The patient is at highest risk of developing which of the following malignancies
A. Renal cell carcinoma
B. Osteosarcoma
C. Pinealoblastoma
D. Chondrosarcoma
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Retinoblastoma
Question: Retinoblastoma is associated with -
A. Osteosarcoma
B. Hepatocellularca
C. SCC
D. Osteoclastoma,
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Retinoblastoma
Question: Retinoblastoma gene is located on a chromosome -
A. 13
B. 6
C. 9
D. 21
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Retinoblastoma
Question: Retinoblastoma gene regulates-
A. Gi - S phase
B. G2 - M phase
C. Go - S1 phase
D. S - G1 phase
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Retinoblastoma
Question: Retinoblastoma spreads to CNS through:
A. Direct
B. Lymphatic
C. Arterial
D. Vitreous
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Retinoblastoma
Question: Retinoblastoma is associated with, which of the following tumors
A. Osteoclastoma
B. Hepatocellular carcinoma
C. Squamous cell carcinoma
D. Osteosarcoma
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Retinoblastoma
Question: Retinoblastoma differs from pseudoglioma by
A. Decreasing Intraocular pressure
B. Blurring of vision
C. Enlargement of optic foramen
D. All the above
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Retinoblastoma
Question: True about Retinoblastoma –a) Leukocoria is most common presentationb) Always unilateralc) May have family historyd) Enucleation is the only treatmente) Most common age group affected is 1–2 year
A. acd
B. bde
C. ace
D. ade
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Retinoblastoma
Question: Retinoblastoma –
A. Is inherited in 50% of cases
B. Is caused by deletion of 11q14
C. Rosettes suggest good prognosis
D. Causes death in 60% of sufferers in the UK
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Retinoblastoma
Question: A patient with known mutation in the 'Rb gene' is 'disease free' from Retinoblastoma. This patient is at highest risk of developing which of the following malignancies?
A. Osteosarcoma
B. Pinealoblastoma
C. Chondrosarcoma
D. Renal cell carcinoma
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Retinoblastoma
Question: Retinoblastoma gene is ,located on chromosome:
A. 13
B. 14
C. 17
D. 22
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Retinoblastoma
Question: Feature common to carcinoma pancreas, lungs,stomach is,a) Retinoblastomab) Migratory thrombophlebitisc) Ascitesd) DIC
A. acd
B. abd
C. abc
D. ab
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Retinoblastoma
Question: Regarding Retinoblastoma all are true EXCEPT:
A. 13q4p mutation
B. Autosomal dominant
C. 25% Bilateral
D. 40% Heritable forms
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Retinoblastoma
Question: Retinoblastoma gene is located on chromosome ?
A. 6
B. 9
C. 13
D. 21
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Retinoblastoma
Question: Following are spontaneous resolution tumours except-a) Malignant melanomab) Osteogenic sarcomac) Cholangio carcinomad) Retinoblastoma
A. a
B. c
C. bc
D. ad
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Retinoblastoma
Question: The differential diagnosis of Retinoblastoma include all of the following except
A. Persistent hyperplastic primary vitreous
B. Coats disease
C. Retinal astrocytoma
D. Retinal detachment
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Retinoblastoma
Question: Retinoblastoma gene is located on:
A. Chromosome 5
B. Chromosome 8
C. Chromosome 13
D. Chromosome 16
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Retinoblastoma
Question: Gene involved in Retinoblastoma
A. 12P13
B. 13P14
C. 12Q13
D. 13Q14
Correct option (0=A, 1=B, 2=C, 3=D): 3
Rare disease: Retinoblastoma
Question: Retinoblastoma best evaluated by-
A. Ultrasonography
B. CT SCAN
C. CT SCAN + MRI
D. MRI
Correct option (0=A, 1=B, 2=C, 3=D): 2
Rare disease: Retinoblastoma
Question: Most common presentation of Retinoblastoma
A. Strabismus
B. Leucocoria
C. Decreased vision
D. Yellowish-white retinal mass.
Correct option (0=A, 1=B, 2=C, 3=D): 1
Rare disease: Retinoblastoma
Question: Pseudoglioma differs from Retinoblastoma in that pseudoglioma is associated with
A. Decreased intraocular pressure
B. Blurring of vision
C. Enlargement of the optic foramen
D. All of the above
Correct option (0=A, 1=B, 2=C, 3=D): 0
Rare disease: Retinoblastoma