UJI, UPV-EHU and CIC bioGUNE patent an in vitro method for predicting the biocompatibility of medical implants



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## UJI, UPV-EHU and CIC bioGUNE patent an in vitro method for predicting the biocompatibility of medical implants

12/05/2017 |
SCP

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Researchers at the Universitat Jaume I (UJI), the University of the Basque Country (UPV-EHU) and the Centre for Cooperative Research in Biosciences (CIC bioGUNE) have patented a new *in vitro* method for predicting the biocompatibility of materials to be used in the manufacture of medical implants, such as joint and dental prostheses, valves and stents.

The patent is based on the detection of a group of proteins linked to the inflammatory reaction. In fact, researchers have identified a profile of protein markers, related to the immune response, that can be analysed in an isolated biological sample *in vitro*, and whose presence above a reference level is indicative of non-biocompatibility *in vivo*. "This methodology," explains the researcher Nuno Araújo, "will enable us to face the experiment *in vivo* with more security in the future, and to reduce the number of animals involved, while reducing time and costs."

The invention consists in an accelerated test of the biocompatibility of materials that makes it possible to discard those with poorer prospects of success during the *in vitro* phase, thus avoiding costly investments in unnecessary *in vivo* studies and facilitating a faster transfer of the new materials to the clinical stage. It accelerates and significantly reduces the development of new implant materials and reduces the number of animals used for experimentation.

The novelty of this methodology lies in fact that a robust correlation has been established between the protein profile obtained in the *in vitro* tests and that acquired by means of *in vivo* trials, which are, by definition, more reliable. Thus, through the *in vitro/in vivo* correlation, the new method enables, through the determination and quantification of such markers in *in* *vitro* samples, to predict the biocompatibility of biomaterials-implants, joint and dental prostheses or catheters, says the main researcher Julio Suay.

The technology is useful for the sectors of manufacturers of medical prostheses and for the producers of biomaterials, as well as for research groups of R & D centres that carry out *in vitro* and *in vivo* tests applied to the development of new materials. In the healthcare sector, it is particularly useful for patients who need an implant. In fact, with a simple blood test, detailed information could be obtained about whether the patient is likely to suffer complications in joint replacement surgery.

**IMAGE:** The researcher, professor Julio Suay Antón (in the center), accompanied by doctoral students Nuno Miguel Araujo da Cunha Gomes (left) and Francisco Javier Romero Gavilán (right).

**PUBLICATIONS**

Francisco Romero-Gavilán; N. C. Gomes; Joaquin Ródenas; Ana Sánchez; Mikel Azkargorta; Ibon Iloro; Felix Elortza; Iñaki García Arnáez; Mariló Gurruchaga, Isabel Goñi & Julio Suay (2017). «Proteome analysis of human serum proteins adsorbed onto different titanium surfaces used in dental implants». Biofouling, 33:1, 98-111 - <http://dx.doi.org/10.1080/08927014.2016.1259414>

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