The UJI studies the mechanisms that lead to a more active lifestyle, brain interactions due to cocaine consumption and tests an online group intervention for cybersex addiction



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## The UJI studies the mechanisms that lead to a more active lifestyle, brain interactions due to cocaine consumption and tests an online group intervention for cybersex addiction

02/11/2022 |
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* [![ pei-psicologia Grup_Investigacio_DLL2219](/com/investigacio/arxiu/noticies/2022/10/pei-psicologia/Grup_Investigacio_DLL2219.jpg)](#)

Research staff from the groups A&N-Addiction and Neuroplasticity, Health Psychology: Prevention and Treatment and NEUROMOTIV-Neuropharmacology of Motivated Behaviour have obtained more than for hundred thousand euros in the latest competitive call of the Spanish Plan for Scientific and Technical Research and Innovation 2021-2023 for the development of three research projects related to the study of the cerebellar-infralimbic circuit to propose a causal model of their interactions due to the effects of cocaine; analysing the efficacy of an online group intervention (e-health) for the treatment of cybersex addiction or understanding the neural mechanisms that lead to active lifestyles.

The study "The cerebellar-infralimbic cortex circuit in cocaine addiction", led by the researcher Marta A. Miquel Salgado-Araújo of the A&N-Addiction and Neuroplasticity group, has obtained almost two hundred thousand euros to investigate the role of the cerebellar-infralimbic circuit in the long-lasting memories that trigger drug use in order to understand the mechanisms underlying these memories in drug addiction and the contribution of the cerebellum to them. It has the collaboration of the Dominick P. Purpura Department of Neuroscience at the Albert Einstein College of Medicine in New York (USA).

Its main objective is to propose a causal model of cerebellar function in drug addiction, but also to open new avenues of study and clinical application to understand comorbidity with other mental disorders, in particular those involving medial prefrontal cortex impairment, such as hyperactivity, schizophrenia or depression, and memory disorders such as post-traumatic stress disorder. To investigate cocaine addiction, state-of-the-art neurobiological techniques such as inducible transgenic models, chemogenetics and optogenetics will be applied, in addition to classical techniques with great heuristic potential such as electrophysiological recordings and drug self-administration protocols.

The project "Controlled study on the efficacy of an online group psychological intervention programme for the treatment of cybersex addiction" is directed by Rafael Ballester Arnal of the Health Psychology: Prevention and Treatment group and Mª Dolores Gil Llario of the University of Valencia. Funded with more than 100,000 euros, it will apply an internationally leading programme of cognitive-behavioural intervention, so far individual, to the group format and will study predictors of therapeutic change in a relevant sample of patients and a control group during treatment and one year after its completion.

Cybersex addiction has a devastating impact on the lives of those who suffer from it and can, at times, pose a danger to the integrity of other people, but there are few therapeutic tools that have demonstrated their efficacy. The study will be based on a controlled experimental design of comparison between three groups (two experimental and one control group) with pre-test, post-test and follow-up to evaluate the effectiveness of the intervention. The aim is to provide the clinic with an effective programme for this increasingly common disorder and will provide, for the first time, data on the effectiveness of a structured group programme in a controlled study specifically for cybersex addiction.

The project entitled "Role of dopaminergic neurotrophic factor (DNFP) in exercise neuroprotection: studies in models of anergy in effort-based decision-making tasks with rodents" is led by the researcher Mercè Correa Sanz of the NEUROMOTIV-Neuropharmacology of Motivated Behaviour group. It has been endowed with almost 100,000 euros and will analyse the best type of exercise to induce neurotrophic factors and compare the neuroprotective effect at different ages and in male and female animals. Animals that are genetically predisposed to anergy will also be studied and an attempt will be made to increase CDNF with exercise to improve their normal activity level.

Preliminary studies in this field have found that the mesolimbic dopamine (DA) system, and in particular the nucleus accumbens (Nacb), regulates the energising component of motivated behaviour as well as effort-related decision-making in both humans and rodents. Today, little is known about the potential of exercise to prevent or help improve motivational symptoms such as fatigue and anergy, but neurotrophic factors are known to play a key role in the survival of neurons and have been shown to be induced by exercise.

**SPANISH RESEARCH PLAN**

The research staff of the Universitat Jaume I of Castelló has obtained 4.17 million euros from the Spanish Research Agency, two more than in the previous call, for the development of 38 new research projects of the Spanish Plan for Scientific, Technical and Innovation Research 2021-2023, which focuses its objectives on the most strategic sectors for recovery, such as health, ecological transition and digitalisation.

The success rate (number of projects approved out of the total submitted) stands at 70% (the national average is 50%) and with an average funding per project of around 110,000 euros and 14 more projects than in the previous edition. With the 2021 call, the Universitat Jaume I reaches 23.7 million euros of funding for R&D&I since the implementation of the Spanish Strategy for Science, Technology and Innovation a decade ago.

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