The Spanish Association Against Cancer is funding a UJI project to develop fluorescent chemical sensors that can detect cancers associated with high oxidative stress



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## The Spanish Association Against Cancer is funding a UJI project to develop fluorescent chemical sensors that can detect cancers associated with high oxidative stress

19/06/2025 |
SCP

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Francisco Galindo ideas-semilla-aecc-sensores-cancer Francisco\_Galindo\_25DLL26
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FYS - Photochemistry and Sensors Group ideas-semilla-aecc-sensores-cancer \_37A5711

FYS - Photochemistry and Sensors Group ideas-semilla-aecc-sensores-cancer \_37A5741

* [![Francisco Galindo ideas-semilla-aecc-sensores-cancer Francisco_Galindo_25DLL26](/com/investigacio/arxiu/noticies/2025/6/ideas-semilla-aecc-sensores-cancer/Francisco_Galindo_25DLL26.jpg)](#)
* [![FYS - Photochemistry and Sensors Group ideas-semilla-aecc-sensores-cancer _37A5711](/com/investigacio/arxiu/noticies/2025/6/ideas-semilla-aecc-sensores-cancer/_37A5711.jpg)](#)
* [![FYS - Photochemistry and Sensors Group ideas-semilla-aecc-sensores-cancer _37A5741](/com/investigacio/arxiu/noticies/2025/6/ideas-semilla-aecc-sensores-cancer/_37A5741.jpg)](#)

Cancer cells exhibit distinct chemical characteristics that set them apart from normal, healthy cells. The biomarkers that signal the presence of cancer are highly diverse, ranging from simple molecules like catecholamines (in gliomas) to complex glycoproteins such as PSA (in prostate cancer). Today, the early detection and monitoring of many types of cancer rely on the analysis of these biomarkers. To identify them, external agents—such as sensors, probes, reagents, or contrast agents—are required, depending on the specific detection technique employed.

The Spanish Association Against Cancer has funded a project led by Francisco Galindo Honrubia, a professor of Organic Chemistry at the Universitat Jaume I in Castelló. The initiative aims to develop fluorescent chemical sensors capable of detecting cancer cells at an early stage, particularly those linked to high oxidative and nitrosative stress. The research will focus on neuroblastoma, triple-negative breast cancer, squamous cell carcinoma, and various types of leukemia.

The sensors to be developed will react with emerging biomarkers, such as reactive nitrogen species (RNS) present in cancer cells with high oxidative-nitrosative stress in some of the types of cancer mentioned above. The research staff of the [FYS - Photochemistry and Sensors Research Group](http://www.uji.es/serveis/ocit/base/grupsinvestigacio/detall?codi=266) at the UJI aims to improve the current fluorescent ROS/RNS probes, providing greater sensitivity and selectivity against other medically relevant species.  
To this end, a collection of chemical sensors will be prepared, which will be exhaustively characterized, and their ability to detect high levels of cellular stress caused by high concentrations of the aforementioned species will be determined. As a proof of concept, those that show the best prospects of success will be tested in pathological samples from collaborators in the field of oncology.

In relation to this project, the researcher Christian Silva García has received a Predoctoral Grant from the Spanish Association Against Cancer to carry out his doctoral thesis under the supervision of Professor Galindo, centered on the development of the aforementioned fluorescent sensors.

The purpose of the AECC Seed Ideas grants is to provide financial support for the generation of new innovative research opportunities in any area of cancer that are developed in Spain and which, if successful, can be turned into solid research projects in basic science, translational science, epidemiology, psycho-oncology and clinical oncology research.

Within the same call for proposals as Professor Galindo, six other researchers have also secured funding. Their projects are supported by institutions such as the University of Córdoba (UCO), the Cancer Research Foundation of the University of Salamanca (FICUS), and research centres including the Hospital del Mar Research Institute in Barcelona, the Neurosciences Institute of Alicante (UMH-CSIC), the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), and La Fe Health Research Institute (IISLAFE).

More information: <https://www.contraelcancer.es/es/investigacion/proyectos-aecc/ideas-semilla-aecc-2024>

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