The UJI is leading a Marie Sklodowska-Curie action to reduce the price of medicines, facilitate their decentralised production and reduce waste



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## The UJI is leading a Marie Sklodowska-Curie action to reduce the price of medicines, facilitate their decentralised production and reduce waste

24/07/2024 |
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* [![ flowbiocat-he 20240724_retrat-victor-gianluca_01](/com/investigacio/arxiu/noticies/2024/9/flowbiocat-he/20240724_retrat-victor-gianluca_01.jpg)](#)

The Universitat Jaume I of Castelló (UJI) is leading a Marie Sklodowska-Curie action of the Horizon Europe programme that aims to integrate chemical engineering (3D printed continuous flow reactors) and biocatalysis (stable and recyclable immobilised enzymes) to achieve more efficient biotransformations that promote the sustainable development of industrial biotechnology.

The proposal of the researcher Víctor Sans Sangorrín, from the group ‘Materials for advanced sustainable production’ of the Institute of Advanced Materials (INAM) of the Universitat Jaume I, and Dr. Gianluca Palmara, who has joined the UJI from the Politecnico di Torino, is to reduce the price of medicines, facilitate decentralised production and reduce waste.

Enzyme-catalysed processes are becoming more and more common because of their high catalytic activity. However, their use is not widespread because they have some drawbacks, such as insufficient stability, high costs associated with their use and poor tolerance to substrates, which limit their use in industrial processes.

The Action "FlowBioCat: Cascade enzyme biotransformations in digitally fabricated continuous flow bioreactors" proposes to overcome these limitations by combining enzyme immobilisation and continuous flow. Immobilisation is a process in which the enzyme is 'trapped' in a defined region of space to obtain insoluble forms that retain their catalytic activity and can be reused repeatedly.

Continuous flow is gaining momentum within the pharmaceutical industry because it allows different components to be incorporated into the same reaction vessel and flow into the reactor at the same time as the resulting products are released. Advantages include faster, safer, more environmentally friendly reactions and better control and reproducibility of reactions. Parameters are more precisely controlled, which improves product yield and impurity control.

Enzymes as catalysts allow synthetic chemistry to generate molecular complexity by avoiding costly and time-consuming protection and deprotection steps. The FlowBioCat approach is to design and manufacture 3D-printed reactors that optimise enzyme stability to develop more efficient flow biotransformations, easy and effective enzyme immobilisation and significantly promote the sustainable development of industrial biotechnology.

The outcome of the project could be of direct benefit to the chemical industry, as clean and efficient production of industrially relevant chemicals is highly desirable in terms of novelty, efficiency and sustainability, as well as cost reduction and energy savings. The project also aims to promote interaction with the business sector related to process technology.

The project is funded by the European Union under the Marie Sklodowska-Curie Actions (MSCA) call of the Horizon Europe programme with grant agreement number 101064606.

More information: <https://www.uji.es/serveis/opei/historico/he/pilar1/pilar1msc/flowbiocat/>

![](https://ujiapps.uji.es/ade/rest/storage/Q2TWP2U0LD1IARTVZCDDHY7J4XTRSIMA)

\*Project funded by the European Union. The views and opinions expressed herein are those of the authors and do not necessarily reflect those of the European Union or the European Health and Digital Executive Agency (HaDEA). Neither the European Union nor the granting authority can be held responsible for them.

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