The AECC and the UJI join forces to make progress in cancer research



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## The AECC and the UJI join forces to make progress in cancer research

26/10/2023 |
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* [![ jornada-aecc Jornada_AECC_23DLL004](/com/investigacio/arxiu/noticies/2023/9/jornada-aecc/Jornada_AECC_23DLL004.jpg)](#)

The Castelló branch of the Spanish Association Against Cancer (AECC) organised the third research conference under the slogan “Patients Need more Research”. It was opened by the Vice-Rector for Research, Jesús Lancis, and the chair of the AECC’s provincial committee, Carlos Ulldemolins.

During the meeting, the doctoral student Raquel Gil Edo, the first recipient of a predoctoral scholarship from the Scientific Foundation of the AECC via the Castelló provincial committee, explained the results of the research carried out for her doctoral thesis “Synthesis and biological evaluation of multitarget anticancer agents for their immunomodulatory, antiangiogenic and anti-vascular effects”, carried out within the Chemistry for Medicine research group under the supervision of professors Eva Falomir and Miguel Carda.

The study, which falls within the field of basic cancer research, has received financial support from the AECC-Castelló with a provision of €134,000, through a four-year predoctoral scholarship (January 2019-March 2023) for the researcher to carry out the study within the Chemistry for Medicine research group in the laboratories of the UJI’s Department of Inorganic and Organic Chemistry.

This type of scholarship is financed thanks to the efforts of both the local community and, in particular, the AECC volunteers in Castelló who go out into the streets to contribute to all its fundraising campaigns on an entirely altruistic basis. These bring in money for investment in research, as well as in helping patients.

The conference also included the participation of Julián Borrás, clinical head of Allergology at the Castelló Provincial Hospital Consortium, who spoke about “Allergo‑oncology: Desensitisation as part of Cancer Treatment” and Inma Conejos, researcher from the Príncipe Felipe Centre in Valencia, who commented on the opportunity for bringing society and science together by means of scholarships like the one offered by the AECC. The exhibition "Cancer Research: a Millennial Challenge" has also been opened in the lobby of the UJI’s Faculty of Health Sciences.

**New anti-tumour molecules**

Raquel Gil Edo has studied the development of new molecules capable of destroying tumour tissue without affecting healthy tissue and encouraging the activation of the body’s defence system against the tumour. The aim of her thesis was to find compounds that could be used in future onco-immunological treatments without causing significant side effects while also preventing metastasis (the spread of the tumour to other tissues).

The work culminated in the development of a series of organic molecules that act in an interesting, unique way because, at non-toxic doses, they are capable of inhibiting tumour growth, dismantling the network of blood vessels that supplies the tumour with the oxygen and nutrients it needs to continue growing, and activating different types of defensive cells that fight the expansion of tumour tissue.

These very promising molecules were designed using previous theoretical calculations carried out in the Chemistry for Medicine research group, and have been synthesised, purified and characterised by Raquel Gil. She has also studied the effect of these compounds on different human adenocarcinoma cell types (breast, lung and colon); non-tumour cell types, and two types of defensive cell type: T-cells and monocytes.

These exhaustive studies observed that the compounds themselves do not cause any kind of toxicity in healthy cells. However, in the presence of defensive cells, some of the compounds designed manage to reduce the number of tumour cells. Moreover, there are compounds that activate non-functional T-cells to destroy tumour cells.

“All the compounds developed in Raquel Gil's thesis are so promising that the research will continue in our group and in the laboratories of the Department of Inorganic and Organic Chemistry to try to develop clinical applications to benefit patients in the future,” said researcher Eva Falomir, head of the Chemistry for Medicine group.

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