Researchers at the UJI open a line of research in genetic therapy for the treatment of Alzheimer’s‬



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## Researchers at the UJI open a line of research in genetic therapy for the treatment of Alzheimer’s‬ On a first phase will be studied the signalling pathways of insulin in the brain and their possible modification through viral particles

27/04/2015 |
SCP

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* [![Group in Neurobiotechnology  alzheimer-neurobiotecnologia GrupNeurobiotecnologia_web](/com/noticies/2015/04/2q/alzheimer-neurobiotecnologia/GrupNeurobiotecnologia_web.jpg)](#)

The research group in Neurobiotechnology of the Universitat Jaume I has started an investigation in genetic therapy for the treatment of Alzheimer’s and other senile dementia diseases funded through the Research Plans of the UJI. The first phase of the study, which began last January, will try to explore the signalling pathways of insulin in the brain and their possible modification since their malfunction seems to be related to brain development processes, neuroprotection and memory, as Ana Maria Sanchez, the project coordinator says.

‪"Alzheimer’s is a disease that is being deeply studied from man different points of view. The prospect of genetic therapy is one of the least developed, so we think that studies like this can be important to start making progress in this therapy. Specifically, this study seeks to go to the early stages of the disease to try to understand why these neurones die and stop or delay their death." One of the factors involved in Alzheimer’s and other neurodegenerative diseases is the resistance to insulin in the brain.

In the first phase, researchers are seeking to manufacture viral particles capable of manipulating the expression of individual genes to improve insulin sensitivity in different brain areas.  ‪In the project converge different disciplines, from biotechnology (molecular biology) to neuroanatomy and behaviour, with the close collaboration of Professor of Anatomy and Embryology, Francisco Olucha.  ‪From this interdisciplinary perspective, the project, which will last three years, aims to progress in the study of the molecular basis underlying diseases like Alzheimer’s.  ‪The ultimate goal would be, as Sánchez says "to produce viral particles that can alter genetic expression in a controlled and specific way to prevent or slow the neuronal death in particular areas of the brain," adding, "as long as funding, increasingly scarce, allows it. Also, with the hope of guaranteeing the progress in research to patients who need it, not just to those who can afford it".

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