Spanish and Brazilian researchers develop bioactive compounds to inactivate SARS-CoV 2 and other opportunistic pathogens



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## Spanish and Brazilian researchers develop bioactive compounds to inactivate SARS-CoV 2 and other opportunistic pathogens

08/10/2021 |
SCP

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* [![ compostos-bioactius image](/com/investigacio/arxiu/noticies/2021/10/compostos-bioactius/image.png)](#)

Pathogenic microorganisms (bacteria, fungi and viruses) represent a serious public health problem that requires the development of advanced materials and new technologies capable of inactivating opportunistic pathogens, thus reducing the risk of infection and transmission.

An international team, led by Professor Juan Andrés, composed of research staff and technologists from the Universitat Jaume I of Castellón, the Centre for the Development of Functional Materials (CDMF) of the Federal University of Sao Carlos, the University of Sao Paulo and the University of Campinas in Brazil, has developed and manufactured bioactive compounds formed by silver phosphate, Ag3PO4 (AP)/polypropylene (PP), using a simple method.

This compound shows high antibacterial activity (against *Staphylococcus aureus* and *Escherichia coli*); antifungal activity (against *Candida albicans*), and inactivates the SARS-CoV-2 virus, responsible for the COVID-19 pandemic, by surface contact. On the one hand, the synthesis method for obtaining the semiconductor, AP, which was mixed with the PP polymer to obtain the active compound, has been improved. The results of the research have been published in *The Journal of Physical Chemistry B*.

Tests on the biocidal action of this material against bacteria, fungi and viruses have been carried out by researchers working directly in the field of health care. In addition to the production and application of the material, the results obtained by quantum calculations and simulations, using advanced methods and techniques of theoretical and computational chemistry, have been fundamental in the development of the research to propose the mechanism of action of this highly biocidal material, based on the formation of oxidising species produced on the surface of the composite.

These compounds have potential for a variety of technological applications due to their broad spectrum of biocidal activity, such as in the manufacture of packaging, fabrics and protective equipment, as well as for surface treatment. The underlying technology based on this compound can be considered as an innovation to protect humans and prevent contamination, transmission and proliferation of SARS-CoV-2 and pathogens.

**Article:**

«Bioactive Ag3PO4/Polypropylene Composites for Inactivation of SARS-CoV‑2 and Other Important Public Health Pathogens». *Journal of Physical Chemistry B*.

<https://pubs.acs.org/doi/full/10.1021/acs.jpcb.1c05225>

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