Researcher Priscila Kosaka stresses the importance of developing ultra-sensitive technologies for early detection of diseases in plasma



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## Researcher Priscila Kosaka stresses the importance of developing ultra-sensitive technologies for early detection of diseases in plasma The lecture of the CSIC scientist has been organised by the Cátedra Ciutat de Castelló

31/03/2023 |
SCP

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Image resource catedra-ciutat-castello Priscila\_Kosaka\_23DLL42
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The Ciutat de Castelló Chair has held at the Menador espai cultural the conference "Improving early detection of cancer: the unknown part of the proteome" by Priscila Kosaka, cancer research scientist at the Spanish National Research Council (CSIC) and FERO Award 2019.

In her speech, the researcher explained that blood contains a series of protein markers that are crucial for the early detection of cancer and other deadly diseases, as well as for personalized medicine. However, she pointed out that although proteomic technologies have been developed in recent years, no useful protein biomarkers have yet been discovered given the complexity of human plasma.

In this regard, Kosaka pointed out that biomarkers for the early detection of cancer are expected to be found in concentrations at least one million times lower than blood proteins, which is well below the current detection limits in proteomics, so she stated that "there is an urgent need for new ultrasensitive technologies that can access the deepest part of the proteome of human plasma".

Thus, the researcher presented an optoplasmic nanosensor recently developed by her team that has demonstrated an unprecedented detection limit in serum, at least six orders of magnitude better than that achieved in routine clinical practice. Moreover, this nanosensor is simple and affordable, so it can be easily deployed in healthcare systems. The technology is currently being applied in clinical trials on samples from breast and lung cancer patients.

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