The Universitat Jaume I launches a crowdfunding project to finance innovative research that blocks Alzheimer's disease with biotechnology



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## The Universitat Jaume I launches a crowdfunding project to finance innovative research that blocks Alzheimer's disease with biotechnology

05/04/2017 |
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Researchers from the Universitat Jaume I (UJI) have launched a crowdfunding project to finance innovative research aimed at slowing down the progress of Alzheimer's disease using biotechnology and nanoparticle engineering techniques. This initiative has been carried out through Precipita, a platform specialized in promoting the collective financing of science created by the Spanish Foundation for Science and Technology (FECYT) from the Ministry of Economy, Industry and Competitiveness. Website is:<https://www.precipita.es/proyecto/biotecnologia-para-combatir-el-alzheimer.html>

Ana María Sánchez, director of the Neurobiotechnology Group and lecturer of Anatomy, explains that her project starts a novel line of research from a technical and conceptual point of view. This line of research sets out "the manufacture of non-harmful viral particles using biotechnological techniques to study neuronal death in the early stages of Alzheimer's disease and restore damaged proteins to slow down its progression."

"We want to advance gene therapy that limits the degenerative process of neurons. To do this, in collaboration with the Universitat Politècnica de València, we are building biological vectors, derived from viruses, and combining them with natural biomaterials, in order to improve the access to the brain of molecules that can stop brain deterioration", explains the researcher.

The project “Biotecnología para combatir el Alzheimer” ["Biotechnology to fight Alzheimer's disease”] will be active during the next three months on the Precipita platform and aims to achieve an optimal target of 25,000 euros. This work is part of one of the lines of research developed by the Neurobiotechnology Group at the UJI, whose mission is to contribute to the knowledge of optimal brain functioning and the consequences that result from chronic inflammatory processes. In fact, its objectives are transversal and, consequently, applicable to other diseases and neurological and psychiatric alterations of an inflammatory nature.

The rise in life expectancy has increased the incidence of neurodegenerative diseases. The highest risk factor for Alzheimer's disease is advanced age: after age 60, the rate increases by 10% every decade. Today, more than 46 million people suffer from dementia worldwide, and if the trend continues, it is estimated that there will be 131.5 million people affected by 2050. For this reason, Ana Sánchez says that her project wants to “contribute to the development of a new therapy that promotes neuronal regeneration and inhibits cell death, and in the future we will try to translate these results to facilitate the recovery of patients with Alzheimer's disease and to spread it to other neurodegenerative diseases.”

The Neurobiotechnology Group from the Universitat Jaume I develops several basic research lines. The first line focuses on the study of intracellular signalling in the brain induced by peptides of the insulin-relaxin family and its effects on behaviour (social behaviour and memory). On the other hand, they study how this signalling can be altered in pathological situations in developmental diseases, like autism and neurodegenerative diseases (Alzheimer's). These issues are addressed using biotechnological techniques and the construction of viral particles and nanoparticles for the *in vivo* modulation of gene expression.

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