ghanaopendata/ghanaian-research-english huggingface dataset:
Effects-of-Fodder-Tree-Leave-Supplementation-for-Basal-Rice-Straw-Diet-on-Rumen-Ammonia-Ph-and-Degradation-Characteristics-in-Sheep

Fodder tree leaves (FTLs) contain high levels of protein, vitamins, and minerals that play a major role in role in enhancing roughage intake by ruminants, thus improving low-quality roughage utilization. The study sought to measure the rumen degradation characteristics, pH, and ammonia N concentration of sheep fed rice straw (RS) and supplemented with FTLs. Four forest-type rumen-fistulated rams of an average weight of 19.0±1.2 kg were randomly assigned to one of four treatments in a 4 × 4 Latin square design. Treatment diets consisted of urea-ammoniated straw (UAS; control), RS+100% Leucaena leucocephala (L), RS+100% Samanea saman (S), and RS+50% L+50% S (LS). The data obtained were subjected to the Glimmix procedure of SAS (2016) and significant means were separated using Tukey’s test at P<0.05. Treatments differed significantly (P<0.001) in the quantity of readily soluble materials (a), rate of degradation (c), and a potentially degradable fraction (P), with LS recording the highest a, c, and P among the treatments. Ruminal pH and ammonia concentrations differed significantly (P<0.0001) among the treatments. Overall mean rumen pH values obtained ranged from 6.44 in UAS to 6.72 in the S-supplemented diet, whereas mean rumen Ammonia values ranged from 4.59 mg/100 ml in sheep fed the UAS diet to 9.15 mg/L in sheep fed the L diet. The pH values obtained imply that the experimental diets could improve rumen fermentation and, hence, serve as good sources of feed for ruminants. The rumen DM degradation values indicated that sufficient amounts of DM would be degraded over a period of time, thus releasing substantial quantities into the small intestines for digestion to provide essential nutrients needed for better animal performance. The rumen ammonia values obtained were higher than the minimum values recommended for optimal microbial activity for animals fed lignocellulosic materials. This indicated that such FTLs could be utilized for moderate animal performance, especially during the dry seasons when natural pastures are qualitatively and quantitatively poor.

Source: UG
Efficacies of Technology-Based Instruction in the University of Cape Coast Distance Education Programme

Technology use in education is essential for effective teaching and learning, and preparing students for the world of work in the 21st century. This study sought to examine the efficacies of technology-based instruction in the University of Cape Coast distance education programme. A between-subject experimental design with three (3) independent groups was employed. Using a simple random sampling technique, 181 participants from three programmes (63:58:60) were given different treatment with regards to teaching and learning. The participants were assessed after 8 weeks of teaching and learning. A two-way ANOVA was conducted to examine gender and channel of instruction effect on the performance of participants within the groups. It was revealed that there is a statistically significant interaction effect (p=.003) with an effect size of .065 and a main effect for the groups (p=.000) with an effect size of .294. However, there is no statistically significant main effect for gender (p=.570). It was concluded from the study that technology-based instruction, when mixed with the traditional teaching method, becomes effective for teaching and learning of distance education students. It was recommended based on the findings that the management of distance education programme of the University of Cape Coast should mount a training course for both students and teachers on technology usage in education so that technology can be effectively integrated into teaching and learning progressively.

Source: UG
Efficacy and possible adverse effects of the oral iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one (L1) in thalassemia major

Eleven patients with beta thalassemia major were entered into the trial of the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1). Their ages ranged from 17 to 26 years (mean +/- SD, 22.3 +/- 2.7). Six were male and five were female. L1 was administered at an initial daily dose of 42.5 to 60 mg/kg as a single dose. After 4 weeks, the dose was increased to 85 to 119 (102 +/- 10.7) mg/kg for 191 to 352 days divided into either two or four doses daily, except for one patient who developed agranulocytosis after 11 weeks and was taken off the trial. Initial serum ferritin values in the remaining 10 patients ranged between 1,000 and 9,580 (5,549 +/- 3,333) micrograms/L and at end of the trial their mean serum ferritin was significantly lower (4,126 +/- 2,278; P less than .05 using the paired t-test). Urinary iron excretion at a daily dose of 85 to 119 mg/kg administered as two divided doses ranged between 0.14 and 0.82 (0.44 +/- 0.26) mg/kg/24 h. In three patients, the four doses per day schedule caused substantially more iron excretion than the same total dose divided into two. During the course of the trial, several possible adverse effects have been encountered. One patient (female, aged 20) developed agranulocytosis 11 weeks after starting treatment and 6 weeks after beginning treatment with a daily dose of 105 mg/kg. This patient's neutrophil count recovered spontaneously 7 weeks after the discontinuation of L1. A decrease in serum zinc levels to subnormal levels was observed in four patients with symptoms of dry skin, with an itchy scaly rash in two that was associated with low serum zinc levels that responded to zinc therapy. Urinary zinc levels ranged from 4.7 to 23.4 (13 +/- 5.5) mumol/24 h and were above 9 mumol/24 h (upper limit of normal) in eight patients. Mild nausea occurred in three patients and transient diarrhea in a fourth. Mild musculoskeletal symptoms occurred in three patients but settled without discontinuation of L1 therapy in two and with temporary discontinuation of L1 in the third. A transient increase in serum aspartate transaminase was also noted in five patients, but serum aspartate transaminase levels subsequently decreased in all of them. No cardiovascular, neurologic, renal, or retinal toxicities were demonstrable. These results confirm that L1 is an effective oral iron chelator. Further clinical trials are needed to determine the incidence and severity of adverse effects.

Source: UG
Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials

Background: Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa. Methods: We pooled data from six double-blind, randomised, placebo-controlled trials (undertaken one each in Tanzania, Mozambique, and Gabon, and three in Ghana) that assessed the efficacy of IPTi with sulfadoxine-pyrimethamine. In all trials, IPTi or placebo was given to infants at the time of routine vaccinations delivered by WHO's Expanded Program on Immunization. Data from the trials for incidence of clinical malaria, risk of anaemia (packed-cell volume <25% or haemoglobin <80 g/L), and incidence of hospital admissions and adverse events in infants up to 12 months of age were reanalysed by use of standard outcome definitions and time periods. Analysis was by modified intention to treat, including all infants who received at least one dose of IPTi or placebo. Findings: The six trials provided data for 7930 infants (IPTi, n=3958; placebo, n=3972). IPTi had a protective efficacy of 30·3% (95% CI 19·8-39·4, p<0·0001) against clinical malaria, 21·3% (8·2-32·5, p=0·002) against the risk of anaemia, 38·1% (12·5-56·2, p=0·007) against hospital admissions associated with malaria parasitaemia, and 22·9% (10·0-34·0, p=0·001) against all-cause hospital admissions. There were 56 deaths in the IPTi group compared with 53 in the placebo group (rate ratio 1·05, 95% CI 0·72-1·54, p=0·79). One death, judged as possibly related to IPTi because it occurred 19 days after a treatment dose, was subsequently attributed to probable sepsis. Four of 676 non-fatal hospital admissions in the IPTi group were deemed related to study treatment compared with five of 860 in the placebo group. None of three serious dermatological adverse events in the IPTi group were judged related to study treatment compared with one of 13 in the placebo group. Interpretation: IPTi with sulfadoxine-pyrimethamine was safe and efficacious across a range of malaria transmission settings, suggesting that this intervention is a useful contribution to malaria control. Funding: Bill & Melinda Gates Foundation. © 2009 Elsevier Ltd. All rights reserved.

Source: UG
Efficacy of Amodiaquine/Artesunate combination therapy for uncomplicated malaria in children under five years in Ghana

The Epidemiology Department contributes to the mission of the institute through basic and applied epidemiological research on, but not limited to, malaria and other diseases of public health importance. It is also home to the Social Science Unit of the Institute, including the Health Support Centre for HIV/AIDS and other communicable and noncommunicable health problems.

Source: UG
Efficacy of behavioural graded activity compared with conventional exercise therapy in chronic nonspecific low back pain: Implication for direct health care cost

Background The relative efficacy of conventional exercise therapy (CET) and behavioural graded activity (BGA) has not been fully established to inform the preference in clinical practice. Go to: Objective To compare CET and BGA on the treatment outcome of chronic non-specific low back pain (LBP). Go to: Methodology Participants were assigned into either BGA or CET group in this randomized feasibility intervention. The CET group received supervised exercise therapy while BGA group engaged in individually prescribed sub-maximal activities based on time-contingent principles. Interventions were carried out twice weekly and over a period of 12 weeks. Outcome measures were numerical rating scale and RAND 36-item health survey which were administered at baseline, week 4 and week 12. Health care cost questionnaire was also administered to evaluate physiotherapy cost after 12 weeks. Mixed design two-way ANOVA with level of significance set as priori at p<0.05 was used to compare both groups. Go to: Results Seventy-seven and half percent (62) participants (CET=29 and BGA=33) with mean ages 45.0±12.2 and 43.1±13.2years respectively, completed the study. Both groups improved significantly (p<0.001) during the intervention. However, there were no significant differences (p>0.05) between the treatment groups at any time points and for any measures assessed. Therapeutic benefits in both groups have bearing on direct health care costs. Go to: Conclusion The results indicate that CET and BGA have similar outcomes in patients with chronic nonspecific LBP with regard to the pain and quality of life. Effective application may however be hampered by the cost-related factors thus suggesting evaluation of health care system in Ghana.

Source: UG
Efficacy of Calneem derived from Ghanaian neem seeds and seed oils from two locations in Cameroon against Sitophilus zeamais (Coleoptera: Curculionidae) on maize

Botanical insecticides are among the most promising alternatives to synthetic insecticides for stored product protection. Calneem oil from Ghana and local neem oils from two localities in northern Cameroon (Garoua and Maroua) were tested at 0 (untreated control), 2, 4, 6, 8 and 12-ml/kg, on the adult and immature stages of the maize weevil Sitophilus zeamais (Motschulsky), for mortality and reproduction inhibition. The neem oils from Cameroon were extracted using the traditional kneading method and a hydraulic press in the laboratory (refined). Maize grains were coated with the five neem seed oils (Calneem, Garoua traditional and refined, and Maroua traditional and refined, respectively) and adult mortality was recorded at 1, 3, 7 and 14 days after exposure. Within 1 day of exposure, the highest tested concentration (12-ml/kg) of Calneem, Garoua traditional, Garoua refined, Maroua traditional and Maroua refined oils caused similar weevil mortality of 86.3, 93.8, 93.8, 97.5 and 97.5%, respectively. The 24-h LC50values for the oils in the same order were 7.0, 6.0, 5.0, 5.0 and 4.8-ml/kg, respectively. The lowest (2-ml/kg) and highest (12-ml/kg) concentrations of the oils suppressed progeny production by over 80 and 98%, respectively. The oils arrested the development of the hidden eggs and immature stages in the maize grains. The results suggested that neem seed oils from different localities of northern Cameroon, irrespective of the method of extraction, were effective for the protection of stored maize against S. zeamais. The promotion of natural neem seed oils as stored grain protectants in Cameroon would boost food security, alleviate poverty and reduce environmental degradation. © 2011 ICIPE.

Source: UG
Efficacy of DEET and non-DEET-based insect repellents against bites of Simulium damnosum vectors of onchocerciasis

The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

Source: UG
Efficacy of ivermectin against Onchocerca volvulus in Ghana - Authors' reply

The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

Source: UG
Efficacy of Lemon Extracts in Controlling Mealy Bugs of Stored Yam (Dioscorea rotundata)

Background: The use of plant extracts in controlling mealy bugs is widespread especially on stored products. Despite this, research on lemon extracts, which is known to be very effective against some insect pests are limited. We assessed the repellent ability of lemon extracts in controlling mealy bug infestation and observed if there was any added benefit of the extract in retarding sprouting of yams in storage. Methods: We used the complete randomized design with three treatments and three replications. The treatments consisted of lemon peels, lemon leaf extracts and a control. Ten tubers of Pona white yam variety were rubbed on the periderm with each treatment and placed on a shelf. Two yam tubers naturally infested with mealy bugs were placed at the edges of each replication to serve as sources of infestation. Result: Results showed that yam tubers treated with lemon peel extracts recorded relatively low mealy bug counts compared to untreated ones and, tubers treated with lemon extracts recorded relatively higher weights compared to those without any treatment. Furthermore, there were no significant differences in neither counted mealy bugs nor yam weight per treatment between extracts from leaves or peels. Lemon extract treatments did not affect sprouting and shelf life of tubers in storage. We conclude that lemon extracts are effective repellents of mealy bugs and can be promoted as a safe bio pesticide for stored yam against mealy bug infestation.

Source: UG
Efficacy of mixing vegetable oils with pirimiphos-methyl against the maize weevil, Sitophilus zeamais Motschulsky in stored maize

Sitophilus zeamais is a major insect pest of stored maize and grain products in the tropics. The toxicity of coconut, groundnut and soybean oils applied at 1, 2, 5 and 10ml/kg and pirimiphos-methyl at 2.5, 5 and 10μl active ingredient in 2ml of water/kg of grain (116, 18 and 14 of the recommended dose), alone or in combination, to adults and immature stages of S. zeamais, the persistence of the treatments in maize grains and their effects on seed viability were evaluated in the laboratory. All the treatments caused significant mortality compared to untreated controls. Low dosages of the oils and pirimiphos-methyl when combined were highly toxic to adult S. zeamais. The mixtures completely inhibited the development of immature stages of the weevil. Only pirimiphos-methyl and the mixtures retained some activity 60 days after application. Pirimiphos-methyl can be used at reduced rates if combined with vegetable oils to control infestations of S. zeamais in stored maize. © 2004 Elsevier Ltd. All rights reserved.

Source: UG
Efficacy of Neem oil and Neemazal against the Larger Grain Borer, Prostephanus truncatus (Horn) in stored maize

The biological activity of neem oil and Neemazalon adult and immature stages of the larger grain borer, Prostephanus truncatus, as well as on its F1 progeny was assessed in stored maize in the laboratory. Repellency and persistency effects of the treatments in grain as well as the effect of the treatments on grain damage were also determined. Neemazal was more toxicto P. truncatus than neem oil. The highest dosage of 0.8ml/200g grain killed 100% adult P. maculatus after 72 h exposure but the same dosage of neem oil resulted in 70% mortality after 96h. The products also caused significant (p<0.05) mortality in P. truncates eggs and larvae, Neemazal provided greater protection to maize grains with no noticeable boreholes on grains' treatedwith 0.6 and 0.8ml/200g grain. All treatments repelled less that 50% P. truncatus adults. Activity of the two product significantly declined (0<0.05) in treated grain after 24 hour of storage following treatment. Neemaza loffered greater protection against both immature stages and adults of P. truncatusin stored maize.

Source: UG
Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial

The main research focus of the Electron Microscopy and Histopathology Department in the past 20 years has been in the areas of enteric diarrhoeas with special emphasis on rotavirus. Through its diarrhoea surveillance studies, the Department has helped to firmly establish rotaviruses as a major cause of diarrhoea in children, and document the circulation of unusual rotavirus genotypes in Ghana. The Department has also recently expanded its diagnostic repertoire to include the identification and characterization of noroviruses, astroviruses, and other enteric viruses.

Source: UG
The efficacy of pharmacological interventions to improve cognitive and behavior symptoms in people with dementia: A systematic review and meta‐analysis

background and Aims: Dementia is becoming a major global public health menace in the aging population affecting 47 million people globally. Dementia has no cure and effective interventions. Treatment of dementia is a big problem. The most common symptomatic medications for cognition, behavior, and global functioning among patients with dementia currently are cholinesterase inhibitors and memantine. However, Information on the effectiveness of cholinesterase inhibitors for dementia is conflicting and controversial. Thus, this makes it difficult for decision‐makers, healthcare providers, patients, and caregivers to decide on the most effective intervention. The current meta‐ analysis sought to investigate the efficacy of pharmacologic interventions to improve cognitive and behavioral symptoms in people with living dementia. Methods: This current systematic review and meta‐analysis used the preferred reporting items for systematic reviews and meta‐analyses to ensure accuracy and comprehensiveness. The Cochrane MEDLINE, Database of Systematic Reviews, and other databases were thoroughly searched for relevant studies. We selected Studies such as randomized controlled trials published in English with a sample size of at least 20 subjects. We selected and applied the random‐effects meta‐analysis as the most preferred model because of the heterogeneity across studies. The computation of the weighted effect size was based on the result from the test of heterogeneity. Results: Twenty‐two studies were finally used in the meta‐analysis. The study subjects who received donepezil 5 mg/day, donepezil 10 mg/day, and galantamine 24 mg/day had improved cognition symptoms (ADAS‐cog) score of −1.46 (95% CI = −2.24, −0.68, z = 3.67, p < 0.001), −2.31 (95% CI = −3.30, −1.31, z = 5.45, p < 0.001) and −3.04 (95% CI = −4.16, −1.92, z = 5.31, p < 0.001) respectively. Conclusion: The current meta‐analysis suggests significant benefits of cholinesterase inhibitors such as donepezil (5 and 10 mg/day) and galantamine on cognitive symptoms.

Source: UG
Efficacy of selected biopesticides on key pests of chilli pepper for increased productivity in Ghana

Chilli pepper is an important food and cash crop in Ghana. Unfortunately, production and marketing are con strained by many insect pests. In this study, the efficacy of five different biopesticides: Neemazal® (Azadirachtin 0.3% w/w EC), Agro blaster® (Pyrethrin I and II 1% w/w), Bypel 1® (Pieris rapae 10000PIB/mg + Bacillus thuringiensis 16000 IU/mg), Cryptogran® (Cryptophlebia leucotreta Granulovirus ≥ 5.1010 OBs/ml) and Attack® (Emamectin benzoate 1.9% w/w EC) were assessed against the major insect pests of chilli pepper. These pests included the false codling moth (FCM), thrips, whiteflies and fruit flies. The study was conducted during the minor and major cropping seasons of 2019 and 2020, respectively, using RCBD plot design in two locations (Legon and Begoro) in southern Ghana. All five tested biopesticides reduced the infestation of the target insect pests. Neemazal® and Attack® were more efficacious than the other three biopesticides in controlling FCM. For fruit flies, the infestation in Neemazal® and Attack® treated plots varied between 0.69 ± 0.60 to 12.84 ± 0.91% and 1.40 ± 0.69 to 9.72 ± 1.27%, respectively against 3.82 ± 0.67 to 21.87 ± 2.14% in control plots. Nee mazal®, Bypel 1® and Attack® significantly reduced thrips population compared to other biopesticides. Apart from Neemazal® and Attack®, Agro blaster® also reduced whiteflies population compared to control plots. The highest yields were recorded in Neemazal® (3.17 ± 0.33 to 4.35 ± 0.22 t/ha) and Attack® (3.05 ± 0.21 to 4.55 ± 0.25 t/ha) treated plots against 2.12 ± 0.31 to 3.06 ± 0.37 t/ha in the control. Therefore, these two bio pesticides are promising and could be used as part of integrated pest management (IPM) against chilli pepper insect pests in Ghana.

Source: UG
Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans

The main research focus of the Electron Microscopy and Histopathology Department in the past 20 years has been in the areas of enteric diarrhoeas with special emphasis on rotavirus. Through its diarrhoea surveillance studies, the Department has helped to firmly establish rotaviruses as a major cause of diarrhoea in children, and document the circulation of unusual rotavirus genotypes in Ghana. The Department has also recently expanded its diagnostic repertoire to include the identification and characterization of noroviruses, astroviruses, and other enteric viruses.

Source: UG