ghanaopendata/ghanaian-research-english huggingface dataset:
Electronic Waste Management in Ghana - Issues and Practices

Electronic waste or e-waste is one of the rapidly growing problems of the world today and comprises of a multitude of components that can have adverse impact on man and the environment if not handled properly. In Ghana, the problem has assumed greater significance not only because of the recent expanded usage of electronic and electrical equipments but also due to “unintended dumping” from developed countries. Generally, lack of appropriate infrastructure and procedures for its disposal and recycling, difficulty in inventorisation, unhealthy conditions of informal recycling, inadequate legislation and poor awareness have been major challenges. Consequently, toxic materials enter the waste stream with no special precautions to avoid the known adverse effects on the environment and human health. Additionally, resources are wasted when economically valuable materials are dumped while unhealthy conditions are created during the informal recycling. Through both qualitative and quantitative research techniques, this paper provides a concise overview of Ghana’s current e-waste scenario, namely, the interrogation of the magnitude of the problem, and examining the current disposal and recycling practices

Source: UG
Elemental evaluation of some herbal plants used in ghana using INAA

Instrumental Neutron Activation Analysis was employed to quantitatively study some elemental contents of some medicinal plants used for the treatment of various ailments in Ghana. The accuracy and precision of the method were guaranteed by analyzing certified reference materials under the same conditions as the samples. Various elements of biological importance for human metabolism were found to be present in varying concentrations. Potentially toxic element when exceeding RDI, Al, was also detected in the medicinal plants considered in this study. The concentrations of the various elements in the medicinal plants have been discussed in detail.

Source: UG
Elemental minerals and microbial compositions as well as knowledge and perceptions regarding kaolin (clay) consumption by pregnant women in the Ho municipality of Ghana

Introduction: kaolin is a type of clay consumed mostly by women especially pregnant women of which the act of clay eating is termed geophagy. Different people use this type of clay for diverse purposes. Notwithstanding, most Ghanaians consume this clay out of cravings, taste and smell. There have been some attendant problems with the consumption of clay especially by pregnant women. This research sought to assess the mineral and microbial contents of kaolin and address the perceptions of pregnant women on geophagy. Methods: this study employed a cross-sectional convenient sampling method to sample 217 pregnant women and sellers of clay (Ayilo). A face-to-face interview was conducted to administer a structured questionnaire to respondents. Mineral and microbial analyses were also conducted on the ore of the kaolin mined from Anfoega in the Volta Region of Ghana using standardized procedures. Results: results from this study suggests geophagy prevalence of 48.4% (n=217) among pregnant women in the Ho municipality of Ghana. Results obtained also suggest smell and taste of the clay, influenced the consumption by these pregnant women to a large extent. Strikingly, majority of the respondents had no knowledge on the adverse health implications clay consumption had on the human body. The physiological state of pregnancy also cause many to use it to treat nausea, other accompanying discomfort and in some instances to quench their hunger. Traces of Lead, Nickel and Arsenic were found in the clay. Common microorganisms ident ified were Bacillus, Pseudomonas, Mucor and Aspergillus spp. Conclusion: geophagy is a common practice among pregnant women living in the Ho municipality in the Volta region, Ghana. Most of them consumed it for varied reasons. Although there are beneficial minerals, accumulated effects of these heavy metals can lead to various complications in pregnancy. The clay also contained pathogenic microorganisms. These pathogens have a whole range of deleterious effects on the human body ranging from gastrointestinal infections to cancer and so may not be safe to consume clay products from Anfoega, Ghana.

Source: UG
Elevated circulating IL-17 level is associated with inflammatory arthritis and disease activity: A meta-analysis

Objectives: Previous studies found that the interleukin (IL)-17 level was elevated in inflammatory arthritis, but results were inconsistent. This meta-analysis aimed to investigate the association of IL-17 cytokine with osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Methods: Relevant studies were searched using databases. Standardized mean difference (SMD) was calculated. Correlation coefficient was utilized to evaluate the relationship between IL-17 and disease activity of AS and RA. Subgroup analysis, sensitivity analysis and meta-regression were applied to explore the sources of heterogeneity. Results: 83 records were enrolled. The IL-17 level was elevated in AS (SMD=2.348, P < .001), RA (SMD=1.502, P < .001), PsA (SMD=1.710, P < .001) and OA (SMD=1.192, P=.016), and similar results occurred in subgroup analysis. Furthermore, the IL-17 level was positively associated with disease activity of AS and RA. Conclusion: Circulating IL-17 level is significantly elevated in inflammatory arthritis and is related to the disease activity of AS and RA, suggesting that it plays an important role in the pathogenesis and progression of inflammatory arthritis (especially in AS and RA).

Source: UG
Elevated IL-17 levels in semi-immune anaemic mice infected with Plasmodium berghei ANKA

Background: Alterations in inflammatory cytokines and genetic background of the host contribute to the outcome of malaria infection. Despite the promising protective role of IL-17 in infections, little attention is given to further understand its importance in the pathogenesis of severe malaria anaemia in chronic/endemic situations. The objective of this study, therefore, was to evaluate IL-17 levels in anaemic condition and its association with host genetic factors. Methods: Two mice strains (Balb/c and CBA) were crossed to get the F1 progeny, and were (F1, Balb/c, CBA) taken through 6 cycles of Plasmodium berghei (ANKA strain) infection and chloroquine/pyrimethamine treatment to generate semi-immune status. Cytokine levels and kinetics of antibody production, CD4+CD25+T regulatory cells were evaluated by bead-based multiplex assay kit, ELISA and FACs, respectively. Results: High survival with high Hb loss at significantly low parasitaemia was observed in Balb/c and F1. Furthermore, IgG levels were two times higher in Balb/c, F1 than CBA. While CD4+CD25+ Treg cells were lower in CBA; IL-4, IFN-γ, IL-12α and IL-17 were significantly higher (p &lt; 0.05) in Balb/c, F1. Conclusions: In conclusion, elevated IL-17 levels together with high IL-4, IL-12α and IFN-γ levels may be a marker of protection, and the mechanism may be controlled by host factor (s). Further studies of F2 between the F1 and Balb/c will be informative in evaluating if these genes are segregated or further apart. © 2018 The Author(s).

Source: UG
Elevated levels of nitric oxide and low levels of haptoglobin are associated with severe malarial anaemia in African children

The Department of Immunology conducts research in the field of immunology of infectious and non-infectious diseases. The Department has the overall goal of contributing knowledge to better diagnosis, management, control and prevention of infectious and non-infectious diseases in Ghana and worldwide. This is consistent with the overall strategy of the Noguchi Memorial Institute for Medical Research (NMIMR) and in line with the strategy of the College of Health Sciences of the University of Ghana.

Source: UG
Elevated Levels of the Endothelial Molecules ICAM-1, VEGF-A, and VEGFR2 in Microscopic Asymptomatic Malaria

The Department of Immunology conducts research in the field of immunology of infectious and non-infectious diseases. The Department has the overall goal of contributing knowledge to better diagnosis, management, control and prevention of infectious and non-infectious diseases in Ghana and worldwide. This is consistent with the overall strategy of the Noguchi Memorial Institute for Medical Research (NMIMR) and in line with the strategy of the College of Health Sciences of the University of Ghana.

Source: UG
Elevations In D-Dimer Levels In Patients With Plasmodium Infections: A Systematic Review And Meta-Analysis.

D-dimer, a byproduct of cross-linked fibrin degradation, arises during the fibrinolysis process, breaking down blood clots in circulation. This systematic review and meta-analysis aimed to synthesize evidence of D-dimer alteration in people with malaria, including variations in disease severity. The systematic review was registered in PROSPERO with registration number CRD42024528245. Searches were performed in EMBASE, Scopus, MEDLINE, PubMed, Nursing & Allied Health Premium, and Journals@ Ovid on March 25, 2024, to identify original studies that reported D-dimer in patients with Plasmodium infections. The methodological quality of the included studies was assessed using the Joanna Briggs Institute critical appraisal tools. Thematic synthesis and meta-analysis were carried out to synthesize the findings of the included studies. A total of 24 studies were included in the review out of 1,115 records identified. According to the evaluated studies, patients with Plasmodium infections had higher D-dimer levels. A meta-analytic evaluation of D-dimer levels between patients with and without Plasmodium infections revealed a significant elevation of D-dimer in patients with infection, with high heterogeneity (SMD=2.11, 95% CI=0.59; 3.64, P=0.007, I² = 98%, 6 studies, 1,418 participants, random-effects model). However, no significant alterations in D-dimer levels were observed following the comparison between patients with severe and uncomplicated malaria, also with high heterogeneity (SMD=2.54, 95% CI = -1.60; 6.68, P=0.23, I² = 99%, 3 studies, 595 participants). The findings suggested that malaria patients have significantly higher D-dimer levels compared to non-malarial individuals. However, there was no significant difference in D-dimer levels between severe and uncomplicated malaria cases. These results highlight the potential of D-dimer as a biomarker for Plasmodium infections, but its clinical utility requires further validation. Future studies should prioritize standardizing D-dimer measurement methods, including assay types, threshold values, and sample types, to ensure consistent and reliable application in clinical settings. Additionally, large, multicentric cohorts are needed to establish robust guidelines for incorporating D-dimer into malaria management practices. Further research should also explore the role of D-dimer in the pathogenesis of Plasmodium infections to deepen our understanding of their clinical significance.

Source: UG
Elimination of lymphatic filariasis in west African urban areas: is implementation of mass drug administration necessary?

The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

Source: UG
The elimination of the onchocerciasis vector from the island of Bioko as a result of larviciding by the WHO African Programme for Onchocerciasis Control

The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

Source: UG
Elimination of trachoma as a public health problem in Ghana: Providing evidence through a pre-validation survey

The Department of Immunology conducts research in the field of immunology of infectious and non-infectious diseases. The Department has the overall goal of contributing knowledge to better diagnosis, management, control and prevention of infectious and non-infectious diseases in Ghana and worldwide. This is consistent with the overall strategy of the Noguchi Memorial Institute for Medical Research (NMIMR) and in line with the strategy of the College of Health Sciences of the University of Ghana.

Source: UG
The Elite, Elitism, and Ensuing Conversations in Ghana’s Higher Education: Myth or Reality?

Contemporary higher education in Ghana and many parts of Africa has European colonial antecedents. In spite of the many goals that it aspired to achieve, a preoccupation was to nurture an elite group. Though widely used, the concept of elite and elitism is vague and hardly conceptualized. It hoovers from status—occupants of the apex or top echelons of an organization/society, to consumption—people with immense wealth. Influence, on the other hand, seems to be a common denominator in both cases. But, does this capture the scope of the phenomenon? This article engages people who have worked in different capacities in Ghana’s higher education space to examine the deeper meanings that could be embedded in elitism, elicits conceptualizations of elitism, and further finds out how elitist higher education is in Ghana. Ultimately, the article intends to initiate a conversation on whether indeed there are elites being produced from the university system. This study was done with reference to an empirical study on decolonizing higher education in Ghana

Source: UG
Elr-type proteins protect Xenopus Dead end mRNA from miR- 18-mediated clearance in the soma

Segregation of the future germ line defines a crucial cell fate decision during animal development. In Xenopus, germ cells are specified by inheritance of vegetally localized maternal determinants, including a group of specific mRNAs. Here, we show that the vegetal localization elements (LE) of Xenopus Dead end (XDE) and of several other germ-linespecific, vegetally localized transcripts mediate germ cell-specific stabilization and somatic clearance of microinjected reporter mRNA in Xenopus embryos. The part of XDE-LE critical for somatic RNA clearance exhibits homology to zebrafish nanos1 and appears to be targeted by Xenopus miR-18 for somatic mRNA clearance. Xenopus Elr-type proteins of the vegetal localization complex can alleviate somatic RNA clearance of microinjected XDE-LE and endogenous XDE mRNA. ElrB1 synergizes with Xenopus Dead end protein in the stabilization of XDE-LE mRNA. Taken together, our findings unveil a functional link of vegetal mRNA localization and the protection of germ-line mRNAs from somatic clearance.

Source: UG
Elucidating the possible mechanism of action of some pathogen box compounds against Leishmania donovani

Leishmaniasis is one of the Neglected Tropical Diseases (NTDs) which is closely associated with poverty and has gained much relevance recently due to its opportunistic coinfection with HIV. It is a protozoan zoonotic disease transmitted by a dipteran Phlebotomus, Lutzomyia/ Sergentomyia sandfly; during blood meals on its vertebrate intermediate hosts. It is a four-faceted disease with its visceral form being more deadly if left untreated. It is endemic across the tropics and sub-tropical regions of the world. It can be considered the third most important NTD after malaria and lymphatic filariasis. Currently, there are numerous drawbacks on the fight against leishmaniasis which includes: non-availability of vaccines, limited availability of drugs, high cost of mainstay drugs and parasite resistance to current treatments. In this study, we screened the antileishmanial activity, selectivity, morphological alterations, cell cycle progression and apoptotic potentials of six Pathogen box compounds from Medicine for Malaria Venture (MMV) against Leishmania donovani promastigotes and amastigotes. From this study, five of the compounds showed great promise as lead chemotherapeutics based on their high selectivity against the Leishmania donovani parasite when tested against the murine mammalian macrophage RAW 264.7 cell line (with a therapeutic index ranging between 19–914 (promastigotes) and 1–453 (amastigotes)). The cell cycle progression showed growth arrest at the G0-G1 phase of mitotic division, with an indication of apoptosis induced by two (2) of the pathogen box compounds tested. Our findings present useful information on the therapeutic potential of these compounds in leishmaniasis. We recommend further in vivo studies on these compounds to substantiate observations made in the in vitro study.

Source: UG
Elucidation of the Genetic Diversity within Some In Situ Shea Germplasm in Ghana

: Shea is an agroforestry tree species known primarily for its rich butter, which contains stearin and tocopherol, and has ultraviolet ray absorption property; it is used in cooking, body care and traditional medicines. This tree is, however, uncultivated and collection of its nuts by rural dwellers is threatened by increased urbanization with its accompanying land use pressure and the need for fuel wood for rural households. There is also increased demand for shea products worldwide necessitating the need for shea improvement strategies. At the apex of this improvement program lies the need for germplasm collection, characterization, conservation and utilization. In order to conserve elite shea materials amidst dwindling shea populations threatened by climate change, there is a need to develop shea germplasm banks based on the representation of genetic and phenotypic variation focusing on known traits. The objective of the study was to evaluate 282 shea accessions for germplasm conservation and to determine the genetic diversity of the collected materials to inform future collections and drive crop improvement strategies. Leaf traits were used to differentiate and group the selected materials. Leaf length ranged between 16.83 cm and 30.85 cm, and leaf blade length ranged between 12.28 cm and 20.68 cm. Petiole length varied between 5.53 cm and 10.2 cm and the blade to petiole ratio was from 1.41 to 2.69. Correlation studies revealed significant negative correlation between the latitude of collection and all leaf traits measured. There was significant positive correlation between blade length and petiole length (0.57), blade length and total leaf length (0.87) and petiole length and breadth (0.49). The collected materials were grouped at 90% into two, based on the morphological descriptors studied. Three different approaches were employed to genetically analyze the materials based on single nucleotide polymorphic markers (SNP). A phylogenetic tree was constructed based on the SNPs generated; this grouped the materials into three, with various subgroups. Principal coordinate analysis also produced three distinct groups with groupings not based on geographical area of collection. Discriminant analysis of principal components (DAPC) also confirmed three groupings. The genetic diversity of the collection was very low (Hs) = 0.0406, which is an indication of potential inbreeding within the shea populations. To conclude, there was higher variation within locations than between locations.

Source: UG
‘Embarrassing Decisions’ about a Necessary Evil: The Nature and Effects of Language Standardization

Whilst language standardization and standard languages are common knowledge, at least, amongst those who have experienced some formal education, the notion of a standard language being a necessary evil, that the processes involved in creating one invariably entail embarrassing decisions, and that it has negative effects on behaviour, might not necessarily be so common. It is that disparity in the conceptualization of standard languages that this paper sets out to discuss. It opens with a brief orientation towards sociolinguistics, the linguistics branch that is best equipped to deal with languages as complex social phenomena. The paper will present the classic model of the processes of language standardization and proceed to discuss some of their inevitable social effects – the stigmatization of most varieties of a language and the subsequent creation of a culture whereby constant moral and aesthetic sociolinguistic value judgements become the norm. It will be reiterated that language is primarily speech and that the notion of a standard language is a myth, an imposed ideological construct. The conclusion takes up the main ideas discussed and ends on the note that standard languages are a necessary evil, but that understanding the issues surrounding them has the potential to enhance social tolerance and harmony.

Source: UG
Embedding quality culture in higher education in Ghana: quality control and assessment in emerging private universities

High quality provision has been one of the key aims of the current reforms in higher educational institutions across the globe since the beginning of the century and the millennium. Consequently this has led to the increasing demand for quality assurance (QA). This report identifies those institutional processes and structures that support the development of an internal quality culture in the emerging private universities in Ghana. The study bases its understanding of “quality culture” on the definition which sees it as referring to an organizational culture characterized by a cultural/psychological element on the one hand, and a structural/managerial element on the other hand. If we take our educational activity as a process, then the process (the activity) requires inputs (information, materials), resources (people, equipment, space) and control (QMS) to produce outputs (products and/or services). QA then is a culture—a way of continuously aiming to improve and do better—and the private universities in Ghana are responding to this. © 2014, Springer Science+Business Media Dordrecht.

Source: UG
Emergence and Characterization of Serotype G9 Rotavirus Strains from Africa

The main research focus of the Electron Microscopy and Histopathology Department in the past 20 years has been in the areas of enteric diarrhoeas with special emphasis on rotavirus. Through its diarrhoea surveillance studies, the Department has helped to firmly establish rotaviruses as a major cause of diarrhoea in children, and document the circulation of unusual rotavirus genotypes in Ghana. The Department has also recently expanded its diagnostic repertoire to include the identification and characterization of noroviruses, astroviruses, and other enteric viruses.

Source: UG