ghanaopendata/ghanaian-research-english huggingface dataset:
Fc Gamma Receptor IIIB NA1/NA2/SH Polymorphisms Are Associated with Malaria Susceptibility and Antibody Levels to P. falciparum Merozoite Antigens in Beninese Children

The Department of Immunology conducts research in the field of immunology of infectious and non-infectious diseases. The Department has the overall goal of contributing knowledge to better diagnosis, management, control and prevention of infectious and non-infectious diseases in Ghana and worldwide. This is consistent with the overall strategy of the Noguchi Memorial Institute for Medical Research (NMIMR) and in line with the strategy of the College of Health Sciences of the University of Ghana.

Source: UG
FDI and Economic Activity in Africa: The Role of Local Financial Markets

This article examines the role local financial markets play in the link between foreign direct investment (FDI) and economic activity. The article uses panel data methods on 32 African countries over the period 1997 to 2008. Our results show that FDI only has a significant effect on economic activity when interacted with financial market variables, namely, private-sector credit and savings. The results of this study imply that FDI is more productive in the presence of well-functioning local financial markets. African governments must therefore pay particular attention to developing further local financial markets to ensure full economic benefits of FDI inflows. © 2012 Wiley Periodicals, Inc.

Source: UG
Fear of COVID-19, perceived academic stress, future anxiety, and psychological distress of Ghanaian university students: A serial mediation examination

The study examined the direct and indirect relationships between fear of COVID-19 (FC), perceived academic stress (PAS), future anxiety (FA), and psychological distress (PD) among students in Ghana. Students (n = 241; female = 64.1%; mean age = 21.54 years, SD = 2.04 years) completed online surveys on fear of COVID-19, perceived academic stress, future anxiety, and psychological distress. Following mediation analysis performed in PROCESS, results revealed that academic stress and future anxiety independently and serially mediated the relationship between fear of COVID-19 and psychological distress. Independently, PAS mediated the relationship between FC and PD, and FA similarly mediated this relationship. Considered together, the effect of FC on PD initially occurred through PAS, and then FA. We conclude that high psychological distress is associated with increased fear of COVID-19, perceived academic stress, and future anxiety of Ghanaian university students.

Source: UG
Fear of COVID-19: Psychological distress and coping among university students in Ghana

The advent of the coronavirus pandemic has impacted the psychological well-being of many people. This study examined the relationship between fear of COVID-19, psychological distress (depression, anxiety, and stress) and coping strategies adopted by undergraduate students in Ghana. A sample of 209 students were recruited to complete online surveys on fear of COVID-19, psychological distress and coping strategies between June and July 2020. Students scored between normal to mild levels of psychological distress but above average scores on fear of coronavirus (M = 19.45, SD = 6.04). Fear of COVID-19 was positively related to psychological distress. Only maladaptive coping was found to be significantly and positively associated with fear of COVID-19. However post-hoc analysis of the components of coping strategies revealed that denial (β = .17, p = .028), venting (β = .18, p = .036) and humour (β = −.18, p = .023; an adaptive coping strategy) were associated with fear of COVID-19. Finally, both adaptive coping and maladaptive coping strategies had a mediating effect on fear of COVID-19 and psychological distress. These findings emphasize the need to design and optimize institutional interventions that will assess psychological distress and fear of COVID-19 levels during this pandemic and provide psychotherapeutic support for students as they return to school.

Source: UG
Fear of Negative Evaluation as a Mediator of the Relation between Academic Stress, Anxiety and Depression in a Sample of Ghanaian College Students

This study examined the mediator effects of the fear of negative evaluation (FNE) on the relation between academic stress and psychological symptoms in a sample of Ghanaian college students (N = 431). A multi-step structural equation modelling (SEM) procedure was used to test the specified mediator model and several fit indices were calculated to assess how well the model fit the data. In addition, path coefficients were calculated to determine whether mediation had been established. The results indicated that the specified model produced a good fit to the data. Moreover, the findings revealed that FNE partially mediated the relation between academic stress and the psychological symptoms of anxiety and depression. Implications for the study’s findings are discussed and recommendations for future research are presented.

Source: UG
Fear, hope and social desirability bias among women at high risk for HIV in West Africa

Background: Self-reports are widely used for measuring behaviour in HIV research and prevention, yet the accuracy of these measures has been shown to be questionable in many cases. Social desirability bias (SDB) is one of the key factors identified as affecting self-report accuracy. Methods: Using in-depth interviews, we examined SDB from the perspective of 60 women at high risk for HIV in two West African countries: Ghana and Nigeria. We solicited suggestions for reducing SDB in the context of HIV research and prevention, and asked for feedback regarding methods currently being employed to reduce SDB. Results: Themes pertaining to fear and a desire to have a better life were pervasive throughout the data. Thematic structure was similar between sites and age groups, although younger women tended to be more concerned about the interview context. Conclusions: Vulnerability of a population should be considered when asking sensitive questions. Audio-computer-assisted self-interviews may not be appropriate for vulnerable populations in developing countries, particularly for older respondents.

Source: UG
Feasibility and acceptability of ACT for the community case management of malaria in urban settings in five African sites

The community case management of malaria (CCMm) is now an established route for distribution of artemisinin-based combination therapy (ACT) in rural areas, but the feasibility and acceptability of the approach through community medicine distributors (CMD) in urban areas has not been explored. It is estimated that in 15 years time 50% of the African population will live in urban areas and transmission of the malaria parasite occurs in these densely populated areas. METHODS: Pre- and post-implementation studies were conducted in five African cities: Ghana, Burkina Faso, Ethiopia and Malawi. CMDs were trained to educate caregivers, diagnose and treat malaria cases in < 5-year olds with ACT. Household surveys, focus group discussions and in-depth interviews were used to evaluate impact. RESULTS: Qualitative findings: In all sites, interviews revealed that caregivers' knowledge of malaria signs and symptoms improved after the intervention. Preference for CMDs as preferred providers for malaria increased in all sites.Quantitative findings: 9001 children with an episode of fever were treated by 199 CMDs in the five study sites. Results from the CHWs registers show that of these, 6974 were treated with an ACT and 6933 (99%) were prescribed the correct dose for their age. Fifty-four percent of the 3,025 children for which information about the promptness of treatment was available were treated within 24 hours from the onset of symptoms.From the household survey 3700 children were identified who had an episode of fever during the preceding two weeks. 1480 (40%) of them sought treatment from a CMD and 1213 of them (82%) had received an ACT. Of these, 1123 (92.6%) were administered the ACT for the correct number of doses and days; 773 of the 1118 (69.1%) children for which information about the promptness of treatment was available were treated within 24 hours from onset of symptoms, and 768 (68.7%) were treated promptly and correctly. CONCLUSIONS: The concept of CCMm in an urban environment was positive, and caregivers were generally satisfied with the services. Quality of services delivered by CMDs and adherence by caregivers are similar to those seen in rural CCMm settings. The proportion of cases seen by CMDs, however, tended to be lower than was generally seen in rural CCMm. Urban CCMm is feasible, but it struggles against other sources of established healthcare providers. Innovation is required by everyone to make it viable.

Source: UG
Feasibility and acceptability of ACT for the community case management of malaria in urban settings in five African sites

Abstract Background The community case management of malaria (CCMm) is now an established route for distribution of artemisinin-based combination therapy (ACT) in rural areas, but the feasibility and acceptability of the approach through community medicine distributors (CMD) in urban areas has not been explored. It is estimated that in 15 years time 50% of the African population will live in urban areas and transmission of the malaria parasite occurs in these densely populated areas. Methods Pre- and post-implementation studies were conducted in five African cities: Ghana, Burkina Faso, Ethiopia and Malawi. CMDs were trained to educate caregivers, diagnose and treat malaria cases in &lt; 5-year olds with ACT. Household surveys, focus group discussions and in-depth interviews were used to evaluate impact. Results Qualitative findings: In all sites, interviews revealed that caregivers' knowledge of malaria signs and symptoms improved after the intervention. Preference for CMDs as preferred providers for malaria increased in all sites. Quantitative findings: 9001 children with an episode of fever were treated by 199 CMDs in the five study sites. Results from the CHWs registers show that of these, 6974 were treated with an ACT and 6933 (99%) were prescribed the correct dose for their age. Fifty-four percent of the 3,025 children for which information about the promptness of treatment was available were treated within 24 hours from the onset of symptoms. From the household survey 3700 children were identified who had an episode of fever during the preceding two weeks. 1480 (40%) of them sought treatment from a CMD and 1213 of them (82%) had received an ACT. Of these, 1123 (92.6%) were administered the ACT for the correct number of doses and days; 773 of the 1118 (69.1%) children for which information about the promptness of treatment was available were treated within 24 hours from onset of symptoms, and 768 (68.7%) were treated promptly and correctly. Conclusions The concept of CCMm in an urban environment was positive, and caregivers were generally satisfied with the services. Quality of services delivered by CMDs and adherence by caregivers are similar to those seen in rural CCMm settings. The proportion of cases seen by CMDs, however, tended to be lower than was generally seen in rural CCMm. Urban CCMm is feasible, but it struggles against other sources of established healthcare providers. Innovation is required by everyone to make it viable.

Source: UG
Feasibility and acceptability of the use of artemether‐lumefantrine in the home management of uncomplicated malaria in children 6–59 months old in Ghana

OBJECTIVE: We assessed the feasibility and acceptability of and the willingness to use artemether-lumefantrine (Coartem) during early, appropriate treatment of malaria/fever in children aged 6-59 months at the community and household level in a rural malaria-endemic area in Ghana. METHOD: In this descriptive study with a pre- post-evaluation of an intervention, community perceptions of fever, health-seeking behaviour and current treatment practices for children aged 6-59 months were ascertained through qualitative research and surveys. The children were counted in a household census and given identification cards. Community-based agents (who were supervised monthly) dispensed a 6-dose-treatment formulation of Coartem over a 4 months period and counseled caregivers on case management and referral. Caregivers who consulted were followed up after 4 days to determine adherence to the treatment regimen. Blister packs of the drugs were inspected where available. The performance of the agents in terms of counselling, advising on referral and reporting was evaluated. Community satisfaction was also assessed qualitatively through focus group discussions and interviews. RESULTS: Three hundred and sixty-three children sought care during the intervention period. All 235 children aged 6-35 months were correctly provided the one tablet per dose per treatment package compared with 119 of 125 children 36-59 months (95.2%). Only 5 of 17 children were referred appropriately. All 334 caregivers followed the correct drug administration schedule, i.e. twice a day for 3 days. Validation of drugs received indicates that all 204 children aged 6-35 months and 103/118 (87.3%) children aged 36-59 months received the correct drug dose. Adherence of agents and caregivers to the treatment was 308/334 (92.5%). Delay in seeking care was reduced from 3 to 2 days. No serious adverse drug reactions were reported. Community members were enthusiastic about the performance of the agents. CONCLUSION: A Home Management of Malaria (HMM) strategy with Coartem using trained community-based agents supervised monthly is feasible, acceptable, and can achieve high levels of compliance within Dangme, West District of Ghana. However, if the intervention is to be sustainable, the agents need to be paid.

Source: UG
Feasibility and cost of using mobile phones for capturing drug safety information in peri-urban settlement in Ghana: a prospective cohort study of patients with uncomplicated malaria.

BACKGROUND: The growing need to capture data on health and health events using faster and efficient means to enable prompt evidence-based decision-making is making the use of mobile phones for health an alternative means to capture anti-malarial drug safety data. This paper examined the feasibility and cost of using mobile phones vis-à-vis home visit to monitor adverse events (AEs) related to artemisinin-based combination therapy (ACT) for treatment of uncomplicated malaria in peri-urban Ghana. METHODS: A prospective, observational, cohort study conducted on 4270 patients prescribed ACT in 21 health facilities. The patients were actively followed by telephone or home visit to document AEs associated with anti-malarial drugs. Call duration and travel distances of each visit were recorded. Pre-paid call cards and fuel for motorbike travels were used to determine cost of conducting both follow-ups. Ms-Excel 2010 and STATA 11.2 were used for analysis. RESULTS: Of the 4270 patients recruited, 4124 (96.6 %) were successfully followed up and analyzed. Of these, 1126/4124 (27.3 %) were children under 5 years. Most 3790/4124 (91.9 %) follow-ups were done within 7 days of ACT intake. Overall, follow up by phone (2671/4124-64.8 %) was almost two times the number done by home visits (1453/4124-35.2 %). Duration of telephone calls ranged from 38 s to 53 min, costing between GH¢0.26 (0.20USD) and GH¢41.70 (27.USD). On the average, the calls lasted 3 min 51 s (SD = 3 min, 21 s) costing GH¢2.70 (0.77USD). Distance travelled for home visit ranged from 0.65 to 62 km costing GH¢0.29 (0.20USD) and GH¢279.00 (79.70USD). Thirty-two per cent (1128/4124) of patients reported AEs. In total, 1831 AE were reported, 1016/1831(55.5 %) by telephone and 815/1831 (44.5 %) by home visits. Events such as nausea, dizziness, diarrhoea, and vomiting were commonly reported. CONCLUSION: Majority of patients was successfully followed up by telephone and reported the most AEs. The cost of telephone interviewing was almost two times less than the cost of home visit. Telephone follow up should be considered for monitoring drug adverse events in low resource settings.

Source: UG
Feasibility of thyroid ultrasonography in field studies in a developing country, Ghana.

This study was carried out to determine the feasibility of using ultrasonography for goitre estimation in the field situation. It is a cross sectional study that was conducted using community based cluster sample. Thyroid sonography was performed on 112 randomly selected school children aged 10 -15 years from two districts in the Greater Accra area of Ghana, using normative values for thyroid volume recommended by WHO/ICCIDD. The mean age of all subjects was 13.5 years+/-0.13 SEM. The male to female ratio was 1:1. The mean height and weight of the children were 1.5 metres+/-0.9 SEM and 38.1 Kg+/-0.7 SEM, respectively. The mean body surface area was 1.27 m2+/-0.2. There were no significant gender differences in their ages (13.6yrs+/-0.2 SEM, 13.4yrs+/-0.1 SEM, respectively) and height (1.50m+/-1.6 SEM, 1.46m+/-1.7 SEM, respectively). The girls (40.0kg+/-1.2 SEM) weighed more than the boys (35.6kg+/-1.1). The mean and median urinary iodine concentration were 82.4+/-8.5 SEM and 67.9 ug/l, respectively. All the children examined had normal thyroid sonogram. The thyroid volumes ranged from 3.6 ml to 15.3ml. The mean thyroid volume was 7.0ml+/-0.2 SEM and the thyroid volume was higher in the girls (7.5ml+/-0.3 SEM) than the boys (6.5ml+/-0.2 SEM). The criteria of thyroid volume per age and sex yielded a goitre prevalence of 1.8 %. In contrast, the criteria of thyroid volume by surface area yielded a goitre prevalence of 8 %. Our study has shown that it is feasible to employ ultrasonography for field studies to determine goitre prevalence in school children in a developing country such as Ghana. However, the best criteria for goitre in children in Ghana, requires to be confirmed in future studies.

Source: UG
Feasibility study for biogas integration into waste treatment plants in Ghana

Biogas (anaerobic digestion) technology is one of the most viable renewable energy technologies today. However, its economic efficiency depends on the investment costs, costs of operating the biogas plant and optimum methane production. Likewise the profit level also rests on its use directly for cooking or conversion into electricity. The present study assessed the economic potential for a 9000 m3 biogas plant, as an alternative to addressing energy and environmental challenges currently in Ghana. A cost-benefit analysis of the installation of biogas plant at University of Ghana (Legon Sewerage Treatment Plant) yielded positive net present values (NPV) at the prevailing discount rate of 23%. Further the results demonstrate that installation of the plant is capital intensive. Biogas used for cooking was by far the most viable option with a payback period (PBP) of 5 years. Sensitivity analysis also revealed cost of capital, plant and machinery as the most effective factors impacting on NPV and internal rate of return (IRR). © 2016 Egyptian Petroleum Research Institute

Source: UG
Febrile illness diagnostics and the malaria-industrial complex: A socio-environmental perspective

Background: Global prioritization of single-disease eradication programs over improvements to basic diagnostic capacity in the Global South have left the world unprepared for epidemics of chikungunya, Ebola, Zika, and whatever lies on the horizon. The medical establishment is slowly realizing that in many parts of sub-Saharan Africa (SSA), particularly urban areas, up to a third of patients suffering from acute fever do not receive a correct diagnosis of their infection. Main body: Malaria is the most common diagnosis for febrile patients in low-resource health care settings, and malaria misdiagnosis has soared due to the institutionalization of malaria as the primary febrile illness of SSA by international development organizations and national malaria control programs. This has inadvertently created a "malaria-industrial complex" and historically obstructed our complete understanding of the continent's complex communicable disease epidemiology, which is currently dominated by a mélange of undiagnosed febrile illnesses. We synthesize interdisciplinary literature from Ghana to highlight the complexity of communicable disease care in SSA from biomedical, social, and environmental perspectives, and suggest a way forward. Conclusion: A socio-environmental approach to acute febrile illness etiology, diagnostics, and management would lead to substantial health gains in Africa, including more efficient malaria control. Such an approach would also improve global preparedness for future epidemics of emerging pathogens such as chikungunya, Ebola, and Zika, all of which originated in SSA with limited baseline understanding of their epidemiology despite clinical recognition of these viruses for many decades. Impending ACT resistance, new vaccine delays, and climate change all beckon our attention to proper diagnosis of fevers in order to maximize limited health care resources.

Source: UG
Fecal Microbiome Composition in Healthy Adults in Ghana

Most research activities involve the use of molecular methods such as regular PCR (PCR), quantitative PCR (Q-PCR), genomic sequence and analysis using different software, genetic engineering, probe hybridization techniques, biological and molecular cloning, evaluation of immune markers for laboratory diagnosis of infections, serological assays involving the use of rapid tests, ELISA-based evaluations and immunofluorescent assay techniques.

Source: UG
Feed the Future Innovation Lab for Genomics to Improve Poultry: a holistic approach to improve indigenous chicken production focusing on resilience to Newcastle disease

Small-scale poultry production in Africa plays a significant role in alleviating malnutrition and poverty in rural communities. Global climate change and infectious poultry disease such as Newcastle disease (ND) have had tremendous negative impact on poultry production and health due to limited biosecurity, cold chain, and inadequate extension service. Genetic selection for enhanced resis tance to ND virus (NDV) offers a promising complementary approach to vaccination and biosecurity in addressing constraints in village production systems. The Feed the Future Innovation Lab for Genomics to Improve Poultry (GIP IL) has led an effort on the identification of genetic markers, genes and signalling pathways associated with enhanced resistance to NDV by conducting NDV challenging experiments in diverse inbred, commercial, and African indigenous chickens. The GIP IL developed a comprehensive genetic selection platform focusing on improved survival time and reduced virus shedding in the face of NDV infection and on enhanced growth rate and egg production. The programme applied the platform for genetic selection and breeding of indigen ous chickens through velogenic NDV natural exposure trials. To improve our understanding of the epidemiology of NDV in Africa, we characterised circulating strains of the virus in Ghana and Tanzania and identified NDV risk factors among local chickens. These data contribute to a body of knowledge useful for guiding disease control efforts, informing vaccine strategies, enhancing biosecurity, and contributing to our overall understanding of NDV dynamics. To gauge the demand for genetically improved

Source: UG