gebhart/patrepeval huggingface dataset:
Principles of Internet Host Configuration (2009)

This document describes principles of Internet host configuration. It
covers issues relating to configuration of Internet layer parameters,
as well as parameters affecting higher layer protocols.
Synthesis of Aliphatic Dienedials,<i>ω</i>-Hydroxydienals,<i>ω</i>-Hydroxy-2-alkenals, Vinylketones, an Enon-enal and Aliphatic Dienediones (1988)

Aliphatic bisenals (1a~n), ω-hydroxydienals (2a~n), ω-hydroxy-2-alkenals (3a~d), vinylketones (4a, b), an enon-enal (4c) and three geometric isomers of aliphatic bisenones (5a~g) were synthesized in order to study the relationship between the structure and microbicidal activity.
Effects of surgically and gastrically implanted radio transmitters on swimming performance and predator avoidance of juvenile chinook salmon (<i>Oncorhynchus tshawytscha</i>) (1998)

Radiotelemetry data are often used to make inferences about an entire study population; therefore, the transmitter attachment method should be the one that least affects the study animal. Juvenile chinook salmon (Oncorhynchus tshawytscha) <120 mm in fork length (FL) with either gastrically or surgically implanted transmitters had significantly lower critical swimming speeds than control fish 1 and 19-23 days after tagging. For fish >120 mm FL, fish with gastric implants swam as well as controls 1 day but not 19-23 days after tagging. In contrast, fish with surgical implants swam as well as controls 19-23 days but not 1 day after tagging. During predation trials, fish with gastric or surgical implants were eaten by smallmouth bass (Micropterus dolomieu) in significantly greater numbers than controls. We do not recommend implanting transmitters (representing 4.6-10.4% of the fish's body weight) in fish <120 mm FL. Furthermore, surgical implants (representing 2.2-5.6% of the fish's body weight) may be the preferred method for biotelemetry studies of juvenile chinook salmon >120 mm FL.
Preference Queries with SV-Semantics. (2005)

Personalization of database queries requires a semantically rich, easy to handle and flexible preference model. Building on preferences as strict partial orders we provide a variety of intuitive base preference constructors for numerical and categorical data, including so-called d-parameters. As a novel semantic concept for complex preferences we introduce the notion of ‘substitutable values’ (SV-semantics), characterizing equally good values amongst indifferent values. Pareto and prioritized preference construction preserves strict partial orders, which instantly solves crucial wellknown problems for preference queries. We can point out a new semantic-guided way to cope with the infamous flooding effect of query engines. Contrary to a wide-spread belief we can give evidence that the result sizes of Pareto or skyline queries not necessarily explode for multiple attributes. Moreover, we can show that known laws from preference relational algebra remain valid under SV-semantics. Since most of these laws rely on transitivity, preservation of strict partial order is essential to algebraically optimize complex preference queries. Similarly, well-known efficient evaluation algorithms for the preference selection operator rely on transitivity. In a nutshell, preference constructors with SVsemantics enable an intuitive and powerful personalization of database queries and at the same time are the key to efficient preference query evaluation. 1.
Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cells (2005)

The oral cavity is a unique environment in which antimicrobial peptides play a key role in maintaining health and may have future therapeutic applications. Present evidence suggests that alpha-defensins, beta-defensins, LL-37, histatin, and other antimicrobial peptides and proteins have distinct but overlapping roles in maintaining oral health and preventing bacterial, fungal, and viral adherence and infection. The expression of the inducible hBD-2 in normal oral epithelium, in contrast to other epithelia, and the apparent differential signaling in response to commensal and pathogenic organisms, provides new insights into innate immunity in this body site. Commensal bacteria are excellent inducers of hBD-2 in oral epithelial cells, suggesting that the commensal bacterial community acts in a manner to benefit the overall innate immune readiness of oral epithelia. This may have major significance for understanding host defense in the complex oral environment.
Evidence for involvement of opioid receptors in ischemic preconditioning in rat hearts (1995)

The purpose of the present study was to investigate a possible role of opioid receptors in ischemic preconditioning (PC). To test this hypothesis, anesthetized, open-chest, male Wistar rats were subjected to five different protocols. In group I, the control group was subjected to 30 min of left coronary artery occlusion and 2 h of reperfusion. In group II, ischemic PC was elicited by three 5-min occlusion periods interspersed with 5 min of reperfusion. In group III, naloxone (NL, 3 mg/kg iv), a nonselective opioid antagonist, was given to nonpreconditioned rats 10 min before the 30-min occlusion period. Finally, NL was administered 10 min before preconditioning (NL + PC, group IV) or immediately after the last 5-min preconditioning period (PC + NL, group V). Infarct size (IS) as a percentage of the area at risk (AAR) (IS/AAR) was determined by 2,3,5-triphenyltetrazolium chloride staining. PC resulted in a marked reduction in myocardial IS from 45 +/- 5 to 8 +/- 1 (P < 0.05). NL treatment before or immediately after PC abolished this protective effect; however, NL had no effect on IS in non-PC rats. These results are the first to support the hypothesis that activation of opioid receptors may play an important role in ischemic PC in the rat myocardium.
Up-Regulation of Peroxiredoxin 1 in Lung Cancer and Its Implication as a Prognostic and Therapeutic Target (2008)

The levels of prx1 transcript were higher than those of prx2 in NSCLC cell lines, and the upstream regulatory sequences of the two genes display striking differences. The relative risk of death increased as Prx1 expression levels increased (P = 0.036) in a multivariate Cox model, independent of other clinicopathologic variables associated with survival. No statistically significant correlation was observed between Prx2 and survival. These results suggest that Prx1 may possess unique functions and regulatory mechanisms in NSCLC which are not shared with Prx2, and that Prx1 may serve as a new prognostic biomarker and therapeutic target in NSCLC.
Supramolecular Complexes from CdSe Nanocrystals and Organic Fluorophors (2001)

Heterosupramolecular structures from CdSe or CdSe/ZnS core/shell nanocrystals and a specially designed organic fluorophore (diazaperylene) have been prepared to investigate the electronic interactions at nanoscopic semiconductor surfaces. To determine the average number of dye molecules per nanocrystal, we monitored the size-dependent molar extinction coefficient of CdSe particles. The NC/dye ratio is depending on the particle size and varies between 3 and 20 dye molecules per nanocrystal. We demonstrate that the fluorescence of the nanocrystals is completely quenched upon the formation of the supramolecular NC/dye complex even if the surface of the CdSe particles is covered with a few monolayers of the high band gap semiconductor ZnS.
URETHROPLASTY BY SCROTAL FLAP FOR LONG URETHRAL STRICTURES (1968)

SUMMARY Seventeen patients have been treated by a new type of urethroplasty, which embodies an inverted U‐shaped flap of scrotal skin. It has certain practical advantages. It is technically easy to perform and can be used to deal with a stricture of any length from one end to the other of the urethra.
Antifreeze (Glyco)protein Mimetic Behavior of Poly(vinyl alcohol): Detailed Structure Ice Recrystallization Inhibition Activity Study (2013)

This manuscript reports a detailed study on the ability of poly(vinyl alcohol) to act as a biomimetic surrogate for antifreeze(glyco)proteins, with a focus on the specific property of ice-recrystallization inhibition (IRI). Despite over 40 years of study, the underlying mechanisms that govern the action of biological antifreezes are still poorly understood, which is in part due to their limited availability and challenging synthesis. Poly(vinyl alcohol) (PVA) has been shown to display remarkable ice recrystallization inhibition activity despite its major structural differences to native antifreeze proteins. Here, controlled radical polymerization is used to synthesize well-defined PVA, which has enabled us to obtain the first quantitative structure-activity relationships, to probe the role of molecular weight and comonomers on IRI activity. Crucially, it was found that IRI activity is "switched on" when the polymer chain length increases from 10 and 20 repeat units. Substitution of the polymer side chains with hydrophilic or hydrophobic units was found to diminish activity. Hydrophobic modifications to the backbone were slightly more tolerated than side chain modifications, which implies an unbroken sequence of hydroxyl units is necessary for activity. These results highlight that, although hydrophobic domains are key components of IRI activity, the random inclusion of addition hydrophobic units does not guarantee an increase in activity and that the actual polymer conformation is important.
Pigment Removal and Pectin Loss During the Continuous, Countercurrent Washing of Sunflower Heads (1996)

Sunflower heads are a promising source of pectin which is naturally low in methoxyl groups. As a pretreatment before pectin extraction, the heads must be washed with water to remove pigments and other impurities. Previous washing studies were limited to small (= 100 g) single-stage batch tests. The objective of this study was to analyze the effects of temperature or water-to-solids ratio on pigment removal and on pectin loss in a bench-scale continuous, countercurrent washing unit. Temperature and water-to-solids ratio ranged from 45 to 75C and 12 to 35 g/g, respectively. The solids flow rate was 4.6 g/min and solids residence time was 15 min. The relationship of pigment removal to water-to-solids ratio was fitted to a nonlinear equation by least squares. Continuous washing conditions were identified which consumed less water, yet achieved more pigment removal compared to batch washing. Thus, continuous washing should reduce wastewater treatment costs.
Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis <i>In Vivo</i> (2015)

Researchers have been searching for an essential filovirus receptor for decades, and numerous candidate receptors have been proposed. However, none of the proposed candidate receptors has proven essential in all in vitro scenarios, nor have they proven essential when evaluated using animal models. In this report, we provide the first example of a knockout mouse that is completely refractory to EBOV infection, replication, and disease. The findings detailed here provide the first critical in vivo data illustrating the absolute requirement of NPC1 for filovirus infection in mice. Our work establishes NPC1 as a legitimate target for the development of anti-EBOV therapeutics. However, the limited success of available NPC1 inhibitors to protect mice from EBOV challenge highlights the need for new molecules or approaches to target NPC1 in vivo.
What Is a Vocational Student? Why VEDS IS Inadequate. (1983)

A simple, rapid, sensitive and high throughput method is described, based on solid-phase disk extraction (SPDE) and gas chromatography-electron capture detection, for the determination of chlorobenzens (CBs) in water samples. The proposed SPDE sample pretreatment method was initially optimized and the optimum experimental conditions were found to be as follows: 500 mL water sample (pH 2.5) extracted and enriched by an Empore 3-stn C18 (octadecyl) SPE disk at flow rate of 5 to 50 mL/min, eluted by 5 mL of acetone and 3 × 5 mL of methylene dichloride. The linearity of the method ranged from 0.02 to 0.4 µg/L for dichlorobenzene isomers, 0.0022-0.044 µg/L for trichlorobenzene isomers, 0.005-0.01 µg/L for tetrachlorobenzene isomers and 0.00025 to 0.005 µg/L for pentachlorobenzenes and hexachlorobenzenes, with correlation coefficients ranging between 0.9991 and 0.9999. The limits of detection were in the low ng/L level, ranging between 0.05 and 4 ng/L. The recoveries of spiked CBs with the external calibration method at different concentration levels in deionized/distilled water, tap water and sea water samples were 99-115, 91-106% and 96-110%, respectively, and with relative standard deviations of 4.5-7.6, 4.2-6.8 and 3.6-6.6% (n = 5), respectively. It is concluded that this method can successfully be applied for the determination of CBs in deionized/distilled water, tap water and sea water samples.
Solder Paste Residue Corrosivity Assessment: Bono Test (2014)

ABSTRACT This paper is in English and Chinese languages. Lead free soldering with no clean solder pastes represent nowadays the most common process in electronic assembly. A solder paste is usually considered as no-clean if it passes all IPC J-STD-004 corrosion tests: copper mirror, copper panel corrosion test, Surface Insulation Resistance (SIR) and Elecrochemical Migration (ECM). Other SIR and ECM tests are described in Bellcore GR-78-CORE and JIS Z3197 standards. Although SIR and ECM tests are recognized by all standards authorities to evaluate the solder paste residue corrosivity after reflow, a more selective method, the Bono test, has been developed and implemented in some French companies as a qualification criterion. It has been proven that compared to common corrosion tests, the Bono test better differentiates the nature of solder paste residues.
Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis. (1990)

Human protectin (CD59) is an 18-20-kD membrane glycoprotein that restricts lysis of human erythrocytes and leukocytes by homologous complement. By directly incorporating protectin into membranes of heterologous cells we observed that protectin did not prevent perforin-mediated killing, whereas complement killing was effectively restricted. Further, no significant enhancement of cell-mediated killing or target killing by purified perforin was observed with anti-protectin antibodies. Thus, in contrast with complement lysis, restriction of lysis by protectin does not apply to cell-mediated killing.
<b><i>Colloquium</i></b>: Optimal control of high-harmonic generation (2008)

High-harmonic generation provides an attractive light source of coherent radiation in the extreme-ultraviolet (XUV) and soft-x-ray regions of the spectrum and allows for the production of single attosecond pulses or pulse trains. This Colloquium covers the control of high-harmonic spectra by temporal and spatial pulse shaping of the driving laser pulses and its implications on time-resolved XUV spectroscopy and attosecond pulse shaping. It summarizes important steps for extending existing pulse shaping techniques and control schemes from the near-infrared or visible part to shorter wavelengths. Using adaptive pulse shaping of the driving laser pulses, several groups have demonstrated control of the high-harmonic spectrum, including the author's work on the complete control over the XUV spectrum of high-order harmonics, generated in a gas-filled hollow fiber. It is possible to achieve both the enhancement and the suppression of single or several selected harmonic orders. These arbitrarily shaped soft-x-ray spectra will allow for important modifications of the resulting harmonic pulses in the temporal domain. This constitutes first steps towards direct attosecond pulse shaping in the soft-x-ray domain. Moreover, high-harmonic generation in a hollow-core fiber can be enhanced by coupling into a single fiber mode using a feedback-controlled adaptive two-dimensional spatial light modulator.
Radiation promotes malignant phenotypes through <scp>SRC</scp> in breast cancer cells (2014)

Despite the fact that ionizing radiation (IR) is widely used as a standard treatment for breast cancer, much evidence suggests that IR paradoxically promotes cancer malignancy. However, the molecular mechanisms underlying radiation-induced cancer progression remain obscure. Here, we report that irradiation activates SRC signaling among SRC family kinase proteins, thereby promoting malignant phenotypes such as invasiveness, expansion of the cancer stem-like cell population, and resistance to anticancer agents in breast cancer cells. Importantly, radiation-activated SRC induced SLUG expression and caused epithelial-mesenchymal cell transition through phosphatidylinositol 3-kinase/protein kinase B and p38 MAPK signaling. In agreement, either inhibition of SRC or downstream signaling of p38 MAPK or protein kinase B effectively attenuated radiation-induced epithelial-mesenchymal cell transition along with an increase in the cancer stem-like cell population. In addition, downregulation of SRC also abolished radiation-acquired resistance of breast cancer cells to anticancer agents such as cisplatin, etoposide, paclitaxel, and IR. Taken together, our findings suggest that combining radiotherapy with targeting of SRC might attenuate the harmful effects of radiation and enhance the efficacy of breast cancer treatment.
Full-wavefield inversion of surface waves for mapping embedded low-velocity zones in permafrost (2014)

ABSTRACT Surface waves are advantageous for mapping seismic structures of permafrost, in which irregular velocity gradients are common and thus the effectiveness of refraction methods are limited. Nevertheless, the complex velocity structures that are common in permafrost environments often yield unusual dispersion spectra, in which higher-order and leaky modes are dominant. Such unusual dispersion spectra were prevalent in the multichannel surface-wave data acquired from our permafrost study site at Barrow, Alaska. Owing to the difficulties in picking and identifying dispersion curves from these dispersion spectra, conventional surface-wave inversion methods become problematic to apply. To overcome these difficulties, we adopted a full-wavefield method to invert for velocity models that can best fit the dispersion spectra instead of the dispersion curves. The inferred velocity models were consistent with collocated electric resistivity results and with subsequent confirmation cores, which indicated the reliability of the recovered seismic structures. The results revealed embedded low-velocity zones underlying the ice-rich permafrost at our study site — an unexpected feature considering the low ground temperatures of −10°C to −8°C. The low velocities in these zones (∼70%–80% lower than the overlying ice-rich permafrost) were most likely caused by saline pore-waters that prevent the ground from freezing, and the resultant velocity structures are vivid examples of complex subsurface properties in permafrost terrain. We determined that full-wavefield inversion of surface waves, although carrying higher computational costs than conventional methods, can be an effective tool for delineating the seismic structures of permafrost.
<b>A Novel Acetylenic Complex of Tungsten(0) Carbonyl</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Novel Acetylenic Complex of Tungsten(0) CarbonylD. P. Tate and J. M. AuglCite this: J. Am. Chem. Soc. 1963, 85, 14, 2174–2175Publication Date (Print):July 1, 1963Publication History Published online1 May 2002Published inissue 1 July 1963https://pubs.acs.org/doi/10.1021/ja00897a036https://doi.org/10.1021/ja00897a036research-articleACS PublicationsRequest reuse permissionsArticle Views204Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Traffic Management Applications for Stateful SDN Data Plane (2015)

The successful Open Flow approach to Software Defined Networking (SDN) allows network programmability through a central controller able to orchestrate a set of dumb switches. However, the simple match/action abstraction of Open Flow switches constrains the evolution of the forwarding rules to be fully managed by the controller. This can be particularly limiting for a number of applications that are affected by the delay of the slow control path, like traffic management applications. Some recent proposals are pushing toward an evolution of the Open Flow abstraction to enable the evolution of forwarding policies directly in the data plane based on state machines and local events. In this paper, we present two traffic management applications that exploit a stateful data plane and their prototype implementation based on Open State, an Open Flow evolution that we recently proposed.
Employer’s Liability for Third-Party Harassment: An ‘Unworkable’ and Superfluous Provision? (2013)

Prior to the Equality Act 2010, only the Sex Discrimination Act 1975—following an amendment in 2008—contained an express provision rendering employers liable for acts of harassment by third parties. The Equality Act 2010 was designed to be a simpler, streamlined and unified anti-discrimination Act (see, for example, B. Hepple, Equality (Oxford: Hart, 2011); A. McColgan, ‘Reconstructing Discrimination Law’ (2007) PL 74; S. Deakin, ‘Editorial’ (to special issue on ‘Equality Law and the Act of 2010’) (2011) 40 ILJ 313). The Act expanded this provision across the seven relevant protected characteristics for harassment—Age, Disability, Gender Re-assignment, Race, Religion or Belief, Sex and Sexual Orientation (section 26(5) Equality Act 2010)—but the coalition government soon announced that they would consult on whether to remove this ‘unworkable’ provision as part of their 2011 plan for growth (HM Treasury, The Plan for Growth (2011), p 53, and later given effect by a Lords’ amendment to the Enterprise and Regulatory Reform Bill 2012–13). Given the earlier insertion into the Sex Discrimination Act, such an expansion seems sensible, as in a unified Act it would be particularly hard to justify it applying solely to sex; but on reflection is the provision unworkable or actually unnecessary?
Laparoscopic Pelvic Floor Repair Using Polypropylene Mesh (2008)

Laparoscopic pelvic floor repair using a single piece of polypropylene mesh combined with uterosacral ligament suspension appears to be a feasible procedure for the treatment of advanced vaginal vault prolapse and enterocele. Fewer mesh erosions and postoperative pain syndromes were seen in patients who had no previous pelvic floor reconstructive surgery.