gebhart/patrepeval huggingface dataset:
Epigenetic Changes: Potential Therapeutic Targets (2003)

Recent advances in human genome research have resulted in novel approaches for the identification of epigenetic modifications associated with cancer. Modulators of DNA methylation and chromatin structure have a dramatic effect on gene expression, cellular proliferation, differentiation, and apoptosis. Molecular pathways regulating epigenetic events that occur during tumorigenesis have been exploited as new targets for therapeutic intervention. Clinical studies exploring the effectiveness of therapeutic agents targeting DNA methylation and acetylation of histones have yielded promising results. Molecular profiles of epigenetic alterations in cancer cells could allow better stratification of patients who may show responsiveness to specific treatments.
The Chatter of Semi-Active On-Off Suspensions and its Cure (1984)

ABSTRACT Semi-active suspensions are those in which otherwise passively generated damper forces are modulated using feedback control and small amounts of control effort. Recently it was discovered that two-stage, ON-OFF, semi-active control would chatter between the ON and OFF states in a manner similar to bang-bang, active control systems. This chatter is dependent upon the switching algorithm. This paper describes the dynamics of this chatter and suggests alternative control policies for its cure.
Three-Dimensional Telomeric Analysis of Isolated Circulating Tumor Cells (CTCs) Defines CTC Subpopulations (2013)

Circulating tumor cells (CTCs) have been identified with the potential to serve as suitable biomarkers for tumor stage and progression, but the availability of effective isolation technique(s) coupled with detailed molecular characterization have been the challenges encountered in making CTCs clinically relevant. For the first time, we combined isolation of CTCs using the ScreenCell filtration technique with quantitative analysis of CTC telomeres by TeloView. This resulted in the identification and molecular characterization of different subpopulations of CTCs in the same patient. Three-dimensional (3D) telomeric analysis was carried out on isolated CTCs of 19 patients that consisted of four different tumor types, namely, prostate, colon, breast, melanoma, and one lung cancer cell line. With telomeric analysis of the filter-isolated CTCs, the level of chromosomal instability (CIN) of the CTCs can be determined. Our study shows that subpopulations of CTCs can be identified on the basis of their 3D telomeric properties.
New synthesis for a highly halogenated styrene (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew synthesis for a highly halogenated styreneLeonard Oro MooreCite this: J. Chem. Eng. Data 1970, 15, 4, 589–590Publication Date (Print):October 1, 1970Publication History Published online1 May 2002Published inissue 1 October 1970https://pubs.acs.org/doi/10.1021/je60047a001https://doi.org/10.1021/je60047a001research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Benzodiazepine Receptor in Normal and Pathological Human Brain (1978)

Benzodiazepines bind with high affinity to a specific benzodiazepine receptor, which occurs exclusively in the central nervous system. The affinity of various benzodiazepines to the receptor closely parallels their pharmacological and therapeutic potency. Binding to the receptor is stereospecific. The receptor is mainly localized in the synaptic membrane fraction and has its highest density in cortical areas of the brain. In Huntington's chorea a decrease in benzodiazepine receptor binding is found in caudate nucleus and putamen, which, at least in putamen, is due to a loss of benzodiazepine receptors apparently located on GABA neurones, which degenerate in Huntington's chorea. The loss of benzodiazepine receptors might explain why the ameliorative effects of benzodiazepines in the early stages of the disease are not sustained in the later stages.
Electrically induced bandwidth broadening in polymer stabilized cholesteric liquid crystals (2011)

The reflection notch bandwidth of a cholesteric liquid crystal (CLC), equal to the product of the liquid crystal (LC) birefringence (Δn), and the pitch length (po), is typically on the order of 50-100 nm in the visible portion of the electromagnetic spectrum. Static bandwidths greater than 100 nm can be observed in CLCs that possess a pitch gradient throughout the thickness of the cell. In this work, we report on polymer stabilized CLC (PSCLC) systems that exhibit electrically controllable, dynamic bandwidths governed by the strength of a direct current (DC) electric field applied across the sample. Symmetric notch broadening which increases linearly with field and reaches a maximum value at 4 V/μm is observed. Removal of the field returns the PSCLC cell to its original optical properties. A seven fold increase in bandwidth was observed for 22 μm thick cells which contained LCs with a small birefringence (∼0.04). A variety of CLC mixtures with small positive or negative dielectric anisotropies are shown to exhibit this reversible dynamic bandwidth broadening. The magnitude of the effect was dependent on the amount of polymer stabilization controlled by initial monomer content. The underlying mechanism is partially elucidated by examining cells simultaneously in transmission and reflection and observing differences when modulating the DC polarity across the cell. Different mechanisms for the observed effects are discussed in terms of consistency with our experimental results.
Evaluation of a Bricked Volume Layout for a Medical Workstation based on Java. (2007)

Volumes acquired for medical examination purposes are constantly increasing in size. For this reason, the computer’s memory\nis the limiting factor for visualizing the data. Bricking is a well-known concept used for rendering large data sets. The volume\ndata is subdivided into smaller blocks to achieve better memory utilization. Until now, the vast majority of medical workstations\nuse a linear volume layout. We implemented a bricked volume layout for such a workstation based on Java as required by our\ncollaborative company partner to evaluate different common access patterns to the volume data. For rendering, we were mainly\ninterested to see how the performance will differ from the traditional linear volume layout if we generate images of arbitrarily\noriented slices via Multi-Planar Reformatting (MPR). Furthermore, we tested access patterns which are crucial for segmentation\nissues like a random access to data values and a simulated region growing. Our goal was to find out if it makes sense to change\nthe volume layout of a medical workstation to benefit from bricking. We were also interested to identify the tasks where\nproblems might occur if bricking is applied. Overall, our results show that it is feasible to use a bricked volume layout in the\nstringent context of a medical workstation implemented in Java.
Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2011)

the various mechanisms by which ROS mediate paradoxical effects are discussed in this article. The outstanding questions and future directions raised by our current understanding are discussed.
Discovery related texts and linguistics: Including frost's 'home burial' (2016)

The mandated study of the concept Discovery requires us to go beyond the prescribed text to explore how different modes and media use visual and written language to convey meaning. The purpose of this discussion is to propose some ways to support students in their study of discovery and specifically to unpack Robert Frost's 'Home Burial' using a systemic functional linguistics approach.
FDA triple header. Food and Drug Administration. (1995)

The Antiviral Drugs Advisory Committee's favorable decisions on 3TC, saquinavir, and d4T in treating advanced HIV disease is discussed, as are study data and resistance issues related to each. While AIDS treatment activists supported the approval of all three drugs, they criticized details of the committee's recommendations. Other topics include the benefits of using stavudine compared with AZT, and combining stavudine with didanosine. A Bristol-Myers trial of this latter combination conducted over 52 weeks is examined.
Using an anterior chamber maintainer to control intraocular pressure during phacoemulsification (1994)

We describe a phacoemulsification technique that uses an anterior chamber maintainer (ACM) to control intraocular pressure. Continuous irrigation through the ACM maintains pressurized intraocular conditions throughout surgery and when the automated system is not activated. Intraocular pressure is stabilized at predetermined levels with minor fluctuations. Viscoelastics can be used in conjunction with the ACM.
The influence of methotrexate on radiation-induced damage to different lengths of the rat spinal cord (1992)

An experimental model in the rat has been used to assess the possible enhancement of damage to the spinal cord when radiation is given in the presence of methotrexate (MTX). The dose of MTX used, 4 mg/kg, was the maximum dose that could be given to the rat, when administered into the cerebral spinal fluid circulation, without risk of serious neurological effects. Lengths of 4, 8 and 16 mm of the cervical spine were irradiated with single doses of X rays. For animals that developed paralysis within 30 weeks, caused predominantly by the presence of white matter necrosis, there was no evidence to indicate that MTX enhanced the radiation response of the rat spinal cord, at least at a more clinically relevant level of effect i.e. a low incidence of paralysis. However, for the doses associated with the 50% level of effect (ED50) to an 8 mm long field a significant (p less than 0.005) enhancement of the response was seen, suggesting a dose modification factor of 1.19 +/- 0.07. This was interpreted in terms of an hypothesis to explain the well documented volume effect for very small fields in the rat spinal cord which is based on the migration of viable cells in the periphery of the irradiated site. The apparent smaller effect seen when only 4 mm of the spine was irradiated might be related to the nature of the lesion induced at doses required to produce paralysis in these small fields; the lesions were not restricted to white matter but were more severe and also involved the grey matter and nerve roots after a slightly shorter latent period.
Potential HIV-1 target cells in the human penis (2006)

Superficial Langerhans' cells on the inner aspect of the foreskin and frenulum are poorly protected by keratin and thus could play an important role in primary male infection. These findings provide a possible anatomical explanation for the epidemiologically observed protective effect of male circumcision.
DC Arc Fault Model Superimposing Multiple Random Arc Noise States on an Average Model (2019)

This paper presents a new series DC arc fault model to provide accurate simulations in systems such as photovoltaic (PV) arrays. The model is derived by observing the different physical arcing states in air which correspond to specific frequency spectrums. The foundation of the model is pink noise, which is used to derive a current noise power spectral density inversely proportional to the square root of the frequency at different slopes depending on the physical state of the arc. The simulated noise is superimposed on an existing DC arc fault model in the time domain. This new modified pink noise model can: 1) increase the accuracy of frequency-dependent attenuation simulations and filtering effects of inverters, converters, and PV panels on arc faults; 2) facilitate the development of detection algorithms that use the frequency domain by reducing the number of real experiments and enabling simulations of arc faults anywhere in the system.
An Adaptive Interleaving Access Scheme (IAS) for IEEE 802.15.4 WPANs (2005)

The key features of IEEE 802.15.4 wireless personal area network (WPAN) standard are the low data rate, short transmission distance, and low power consumption. The WPAN consisting of coordinator and device nodes is often established for monitoring the environmental information in a periodic fashion. The most critical issue of IEEE 802.15.4 WPAN is the capability of dealing with real-time or near real-time services, which require the limited latency and delay jitter. Two parameters, named as beacon order (BO) and superframe order (SO), are defined to control the superframe length as well as the active and inactive periods in superframe. However, using two parameters is very difficult to achieve deliver smooth and constant data stream from device nodes to coordinator. Although standard allots a portion of active period to be the guarantee time slots (GTS) for real-time services, the access interval of real-time frames is still affected by the assigned superframe length. Instead of using the inefficient GTS scheme, this paper proposes an adaptive interleaving access scheme (IAS) with a parameter interleaving order (IO) to adjust the superframe structure such that the active portion is spread over entire superframe in order to control the access latency as well as the bandwidth wastage. The simulation results demonstrate that the proposed IAS not only decreases average data renew interval (i.e. access latency) but also increases the battery lifetime of device nodes.
A novel method for tissue segmentation in high-resolution H&E-stained histopathological whole-slide images (2019)

Tissue segmentation in whole-slide images is an important task in digital pathology, required for efficient and accurate computer-aided diagnostics. Precise tissue segmentation is particularly significant for a correct diagnosis in cases, when tissue structure of a specimen is very porous, such as skin specimens. In this paper, we addressed the problem of fore- and background segmentation in histopatological images of skin specimens stained with hematoxylin and eosin (H&E), which has not been solved yet, by a novel method based on a combination of statistical analysis, color thresholding, and binary morphology. We validated our algorithm on large extracts from 60 high-resolution whole slide images, with differing staining quality and captured under varying imaging conditions, from three laboratories. The size of extracts varies from 2000×1500 to 20000×30000 pixels and the number of images used in our study matches the number of H&E images used by other research teams. We compared our method to the published ones (GrabCut and FESI) and showed that our approach outperforms its counterparts (Jaccard index of 0.929 vs. 0.776 and 0.695).
Inherited deletion of subband Xp21.13 in a male with Duchenne muscular dystrophy. (1988)

The chromosomes of a male patient who suffers from Duchenne muscular dystrophy (DMD) with a molecular deletion were examined with an improved high resolution R type replication banding technique. High resolution cytogenetic analysis of the proband revealed a deletion of the Xp21.13 subband. His healthy mother was heterozygous for the deletion, which is subject to random X inactivation in lymphocytes. The X chromosomes of the proband's grandmother were normal, suggesting that the deletion of the Xp21.13 subband in the mother was a new mutation. The finding of a very small, cytologically visible Xp21.1 deletion in a male DMD patient with a molecular deletion emphasises the importance of resolving the fine structure in the Xp21 region.
A Chemically Disrupted Proximity System for Controlling Dynamic Cellular Processes (2019)

Chemical methods that allow the spatial proximity of proteins to be temporally modulated are powerful tools for studying biology and engineering synthetic cellular behaviors. Here, we describe a new chemically controlled method for rapidly disrupting the interaction between two basally colocalized protein binding partners. Our chemically disrupted proximity (CDP) system is based on the interaction between the hepatitis C virus protease (HCVp) NS3a and a genetically encoded peptide inhibitor. Using clinically approved antiviral inhibitors as chemical disrupters of the NS3a/peptide interaction, we demonstrate that our CDP system can be used to confer temporal control over diverse intracellular processes. This NS3a-based CDP system represents a new modality for engineering chemical control over intracellular protein function that is complementary to currently available techniques.
Dynamic simulation of a kinematically redundant manipulator system (1987)

Abstract A number of methods have been proposed for the control of kinematically redundant manipulators, that is, those with more than the minimum number of degrees of freedom. This article uses a dynamic simulation to test whether proposed schemes should, in fact, work well when the dynamics of the actual system are considered. In order to perform a realistic simulation, a nine‐degree‐of‐freedom arm has been designed using commercially available motors. The simulation shows the effects that specifying a secondary goal has on the satisfaction of the primary goal. Also shown is the dependence of servo performance on modeling the load.
The front-end SOC for a Blu-ray disc recorder (2004)

This article introduces issues on the implementation of a front-end processor for Blu-ray disc (BD) recorder applications. This processor includes partial response maximum likelihood, a data processor block, and servo blocks. The nonlinear equalizer is designed to boost high-frequency signal components without increasing intersymbol interference. It can improve the quality of the high-frequency signal fed into the Viterbi detector, reduce jitter, and offer more tilt margins to the system. Due to the proposed nonlinear equalizer in PRML, less than 2 × 10/sup -4/ of the symbol error rate (SER), defined as the BD format book, is achieved with the tangential tilt margin of /spl plusmn/0.5/spl deg/. This system on a chip carries DP functions of a parity preserve/prohibit repeat minimum transition runlength (RMTR) (17PP) modem, Reed-Solomon (RS) codec, and buffer management. The Teaklite DSP is embedded for control functions such as focus servo, track servo, and auto calibration. It contains 12 million transistors in a 50 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> die, and is fabricated in 0.18 μm 1-poly 5-metal (1P5M) CMOS technology.
A Silent Build-up in Seismic Energy Precedes Slow Slip Failure in the Cascadia Subduction Zone (2019)

We report on slow earthquakes in Northern Cascadia, and show that continuous seismic energy in the subduction zone follows specific patterns leading to failure. We rely on machine learning models to map characteristic energy signals from low-amplitude seismic waves to the timing of slow slip events. We find that patterns in seismic energy follow the 14-month slow slip cycle. Our results point towards a recurrent build-up in seismic energy as the fault approaches failure. This behavior shares a striking resemblance with our previous observations from slow slips in the laboratory.
The security of static typing with dynamic linking (1997)

Dynamic linking is a requirement for portable executable content. Executable content cannot know, ahead of time, where it is going to be executed, nor know the proper operating system interface. This imposes a requirement for dynamic linking. At the same time, we would like languages supporting executable content to be statically typable, for increased efficiency and security. Static typing and dynamic linking interact in a security-relevant way. This interaction is the subject of this paper. One solution is modeled in PVS, and formally proven to be safe.
The derivation and application of design equations for ferroresonant voltage regulators and regulated rectifiers (1971)

Design equations for the most commonly used ferroresonant regulators and regulated rectifiers are derived. Expressions relating the physical size of the components and the short circuit characteristic of the circuit to the output power, frequency, input power factor, and voltage levels are developed. Frem these expressions, design equations that optimize the design are obtained and specific component values are recommended. For regulated rectifiers, the design of the filter and the effect of the filter on the design of the basic regulator are discussed. The effect of deviating from the recommended values and the effects of nonlinearities not considered in the derivations are discussed, Design examples and data are presented.
Las últimas normas contra el fraude en el ámbito laboral y de Seguridad Social (2013)

La entrada en vigor de la Ley 13/2012, de 26 de diciembre, de «lucha contra el empleo irregular y el fraude a la Seguridad Social», ha venido a culminar un proceso iniciado por el Gobierno, a principios del ano 2012, tras la aprobacion de un conjunto de medidas destinadas a luchar contra todos aquellos actos que persiguen evitar el cumplimiento de las obligaciones en materia laboral y de Seguridad Social.
Tissue–Specific Growth Suppression and Chemosensitivity Promotion in Human Hepatocellular Carcinoma Cells by Retroviral–Mediated Transfer of the Wild–Type P53 Gene (1996)

Selective expression of cytotoxic gene products in tumor cells is one of the goals of gene therapy for treating cancer. We are developing such a strategy for the treatment of human hepatocellular carcinoma (HCC) by linking the wild-type p53 (WT-p53) gene with HCC-associated transcriptional control elements (TCE) to achieve selective growth inhibition of retrovirally transduced HCC cells. Replication-defective, amphotrophic retroviruses were constructed containing a WT-p53 complementary DNA (cDNA) that is transcriptionally regulated by the HCC-associated alpha-fetoprotein (AFP) gene TCE. Expression of exogenous WT-p53 from this retroviral vector was limited to AFP-producing cells. Introduction of WT-p53 into AFP-positive HCC cells by retroviral infection markedly inhibited their clonal growth in monolayer and soft agar cultures, and increased the sensitivity of these cells to the chemotherapeutic drug, cisplatin. Therefore, restoration of WT-p53 expression in HCC cells, in combination with chemotherapeutic drugs, can be considered as a strategy for the therapy of human liver cancer.
Intergranular Stress Corrosion Cracking of Austenitic Stainless Steel at Temperatures Below 100 C — A Review (1982)

The environmental and metallurgical factors in the intergranular stress corrosion cracking of austenitic stainless steel at temperatures below 100 C has been examined. The behavior of annealed and sensitized microstructures in a variety of environments, including oxygen-containing pure water and aqueous solutions containing species such as chloride, fluoride, polythionates, and other sulfur species is reviewed. Particular emphasis is placed on the role of sulfur oxyanions as aggressive species that can induce intergranular cracking at very low concentrations in industrial environments. Electrochemical and metallurgical aspects associated with the development of intergranular cracks in these environments are thoroughly discussed, and the mechanistic implications are addressed.