gebhart/patrepeval huggingface dataset:
Abstract LB-281: Inhibition of Hedgehog results in altered regulation of c-jun and of ERCC1 in cisplatin-resistant A2780-CP70 human ovarian cancer cells (2010)

Abstract Cancer stem cells are presumed to be highly resistant to chemotherapy. Activation of the Hedgehog pathway has been reported as necessary, for the cancer stem cell state. A key gene in the Hedgehog pathway is Gli1. Resistance to platinum compounds is due in part, to up-regulated nucleotide excision repair, NER. ERCC1 is a key marker for NER activity. Transcriptional control of ERCC1 occurs in part, through c-Jun. Upon treatment with cisplatin, cisplatin-resistant A2780-CP70 cells normally up-regulate c-jun and c-fos, which then up-regulate ERCC1 and other NER genes. More specifically, the c-jun Ser63/73 cascade is up-regulated, with up-regulation of activator protein 1 (Reed, JBC 1998). We studied the relationship between Gli1 expression, ERCC1 expression, and cisplatin resistance in the human ovarian cancer cell lines A2780 and A2780-CP70. A2780-CP70 cells are 10-15 fold more resistant to cisplatin than A2780 cells. We used two different probes to modulate the Hedgehog pathway: a) cyclopamine as a pharmacologic inhibitor of the Smoothened; and, b) an anti-Gli1 shRNA to specifically inhibit Gli1. At baseline, cisplatin-resistant cells, expressed &gt; 10-fold more Gli1 protein than cisplatin-sensitive cells. In cisplatin-resistant cells, Gli1 protein was down-regulated in response to cyclopamine, and to anti-Gli1 shRNA. When A2780-CP70 cisplatin-resistant cells are pretreated with cyclopamine, or anti-Gli1 shRNA, the following events occur. The c-jun Thr91/93 cascade is upregulated, which is associated with pro-apoptotic processes. The c-jun Ser63/73 cascade is suppressed. This cascade is associated with pro-growth processes. If cisplatin is given after cyclopamine or anti-Gli1 pretreatment; Gli1 protein is down-regulated; the c-jun Thr91/93 cascade is upregulated; the c-jun Ser63/73 cascade is suppressed; and cells do not up-regulate ERCC1, XPD, or XRCC1. Thus, the normal cisplatin-induced up-regulation of these three genes involved in NER (ERCC1, XPD) and in base excision repair (XRCC1), is suppressed by suppression of the Hedgehog pathway. We conclude that Gli1 and/or other genes involved in the Hedgehog pathway (which is critical for cancer stem cells), may play key roles in the up-regulation of DNA repair genes, specifically in response to DNA damaging agents such as cisplatin. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-281.
A new approach to very low-rate speech coding using temporal decomposition (2002)

Temporal decomposition (TD) is a method to reduce the correlation between speech spectral parameter sets using orthogonalization. The resulting parameters (so-called weightings or target vectors) correspond, mostly, to least-dependent phonetic states, which produce the desired sounds. Other phonetic states can be interpreted as transition states which force the event functions to overlap. On the basis of this assumption, we propose to approximate the event functions by sample functions to focus on the phonetically important states, and to use the resulting parameters for constructing a very low-rate speech coder. The objective and subjective evaluation of synthesized speech, mostly from the intelligibility view point, confirm the assumptions made on the events.
Studies on Carcinostatic Substances. XXXVII. Preparation of Derivatives of Nitrogen Mustard having Metal Chelate-forming Activity. (1961)

Derivatives of nitrogen mustard having metal chelate-forming activity and their copper chelates were prepared and their chemical properties and their chemical properties and their antitumor effect on Yoshida sarcoma were discussed.
Context and selection of schools (2008)

The schools described in these five case studies share a number of characteristics, but also differ considerably in some particular respects. They are all Specialist Schools, a status earned by secondary schools in England through detailed self-analysis, written applications, and rigorous formal assessment.
A quantum chemical approach to the design of chiral negative index materials (2007)

This paper presents methodology developed for the computational modeling and design of negative refractive index materials (NIMs) based on molecular chirality. An application of the methodology is illustrated by ab initio computations on two organometallic molecules which constitute the monomer units of a chiral polymer. Comparisons with experimental data for the polymer are made. Even though the resulting chirality parameter for the pristine material is small, it is shown that negative index can be achieved by introducing sharp plasmonic resonances with metal nanoparticle inclusions.
The Production of Ductile Titanium (1940)

Titanium is a very active metal and special precautions are necessary to prepare it free from oxygen and nitrogen. <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="ML1" overflow="scroll"> <mml:msub> <mml:mi mathvariant="normal">TiCl</mml:mi> <mml:mrow> <mml:mn>4</mml:mn> </mml:mrow> </mml:msub> </mml:math> is reduced with pure magnesium in a molybdenum‐lined crucible, in the presence of pure argon, at a temperature of about 1,000° C. The metal is separated from magnesium salts by leaching and acid treatment. There is no alloying of titanium with magnesium. The powdered Ti metal is compressed into bars and melted in a special vacuum apparatus. The absence of all gases that might react with the metal is of special importance. After melting, the Ti is easily rolled hot. A strip less than 1 mm. thick can be bent cold without fracture.
Clinical Impact of the Over-Expression of Efflux Pump in Nonfermentative Gram-Negative Bacilli, Development of Efflux Pump Inhibitors (2008)

In this manuscript, we want to review the biochemical and genetic characteristics of the different efflux pumps involved in both intrinsic and acquired multiresistance in non-fermentative Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia, as well as the regulation of their expression. Moreover, the clinical impact of the over-expression of these efflux pumps and the investigation developed to define efflux pump inhibitors will be discussed. In this review it will be stated that antimicrobial resistance associated with the over-expression of MDR efflux pumps is widely recognised as a frequent multidrug resistant determinant in nonfermentative Gram-negative bacilli. Moreover, MDR pumps contribute to the intrinsic resistance of these bacterial pathogens. Circumventing the activity of efflux pumps will thus have clear benefits for therapy, since this will increase the susceptibility of nonfermentative Gram-negative bacilli, thereby increasing the therapeutic efficacy of antibiotics used for treating such infections by those pathogens. In addition, it has been shown that the lack of activity of MDR pumps impedes selection of mutants showing high-level antibiotic resistance to antibiotics like quinolones or beta-lactams. Thus, besides reducing intrinsic resistance, inhibitors of efflux pumps will reduce the emergence of mutants that acquire antibiotic resistance as the consequence of mutations in MDR-regulatory elements or in other targets. Recent advances on the search for inhibitors of MDR pumps will also be finally discussed.
Improved fluorogenic assay for rapid detection of Vibrio parahaemolyticus in foods (1990)

An improved fluorogenic assay for the rapid detection of Vibrio parahaemolyticus was developed. In the improved assay, the enrichment of V. parahaemolyticus was carried out in arabinose-glucuronate medium (0.5% arabinose, 0.25% glucuronate, 0.1% polypeptone, 0.1% yeast extract, 0.1% ammonium sulfate, 2% NaCl, 2 micrograms of polymyxin B sulfate per ml, pH 8.5) at 37 degrees C. After the cultivation, the trypsinlike activity of the bacteria was measured by fluorescence with the fluorogenic substrate benzoyl-L-arginine-7-aminomethylcoumarin. Even in the presence of 3 x 10(5) cells of Vibrio alginolyticus, 20 cells of V. parahaemolyticus were clearly detected after a 6-h enrichment cultivation by the assay. Fifty contaminated samples of 14 seafoods were examined for V. parahaemolyticus by the fluorogenic assay after enrichment cultivation for 6 or 8 h. The results were then compared with those obtained by the conventional bromothymol blue Teepol agar assay and the most-probable-number method. There was a linear relationship between trypsinlike activity measured by the assay and the number of V. parahaemolyticus cells in seafood as determined by the bromothymol blue Teepol agar and most-probable-number methods. Correlation coefficients were 0.95 and 0.93 after a 6-h cultivation and an 8-h cultivation, respectively. The presence of 10 cells of V. parahaemolyticus per gram of seafood sample was detected after a 10-h total detection time by the fluorogenic assay.
Synthesis,Characterization,Antibacterial Activities and DNA Interaction of Ternary Copper(II) Complex with 2-(4′-Thiazolyl) Benzimidazole and L-Alaninate (2012)

A new ternary copper(Ⅱ) complex: [Cu(TBZ)(L-Ala)(H2O)]ClO4,was synthesized and characterized by elemental analysis,molar conductivity,infrared absorption spectrum,and electronic absorption spectrum.The complex was assayed against gram-positive(Staphylococcus aureus,Bacillus subtilis) and gram-negative(Salmonella typhi,Escherichia coil) bacteria by double dilution method,and the interaction of the complex to DNA was investigated by electronic absorption spectrometry,fluorescence spectrometry,CD spectrometry,viscosity measurement and agarose gel electrophoresis.The results indicated that the complex had good antibacterial activity,which could be bound to CT-DNA(calf thymus DNA) by intercalative mode,cleave pBR322 DNA in the presence of vitamin C in the involvement of the hydroxyl radical,and possibly singlet oxygen.
Recuperació i estudi d'una màquina d'Atwood de la Facultat de Física de la Universitat de Barcelona (2010)

Mitjancant un conveni de col·laboracio amb la Facultat de Fisica de la Universitat de Barcelona, el taller de restauracio de l�Escola d�Art i Disseny de la Diputacio de Tarragona, a Tortosa, ha recuperat un interessant aparell per a l�ensenyament de la fisica mitjancant demostracions experimentals. Es tracta d�un instrument dissenyat pel cientific angles George Atwood per a l�estudi i la mesura de l�acceleracio i en particular de la caiguda dels cossos i del calcul de l�acceleracio de la gravetat. El present treball realitza un examen de la precisio amb mesures reals efectuades amb l�aparell i conclou explicant el proces d�intervencio i recuperacio.
PC Hardware in a Nutshell, 2nd Edition (2002)

Carefully researched and written, PC Hardware in a Nutshell, 2nd Edition is packed with useful and unbiased information, including how-to advice for specific components, ample reference material, and a comprehensive case study on building a PC. To the point yet complete, this book provides an enormous amount of timeless information intended for anyone who buys, builds, upgrades, or repairs PCs in a corporate, small business, or home setting. In addition to coverage of the fundamentals and general tips about working on PCs, this book includes chapters focusing on motherboards, processors, memory, floppies, hard drives, optical drives, tape devices, video devices, input devices, audio components, communications, power supplies, and maintenance. Special emphasis is given to upgrading and troubleshooting existing equipment so you can get the most from your existing investments. This new edition is expanded to include: Detailed information about the latest motherboards and chipsets from AMD, Intel, SiS, and VIAExtensive coverage of the Pentium 4 and the latest AMD processors, including the Athlon XP/MPFull details about new hard drive standards, including the latest SCSI standards, ATA/133, Serial ATA, and the new 48-bit Big Drive ATA interfaceExtended coverage of DVD drives, including DVD-RAM, DVD-R/RW, and DVD+R/RWDetails about Flat Panel Displays, including how to choose one (and why you might not want to)New chapters on serial communications, parallel communications, and USB communications (including USB 2.0)Enhanced troubleshooting coverage PC Hardware in a Nutshell, 2nd Edition provides independent, useful and practical information in a no-nonsense manner with specific recommendations on components. Based on real-world testing over time, it will help you make intelligent, informed decisions about buying, building, upgrading, and repairing PCs in a cost effective manner that will help you maximize new or existing computer hardware systems.
Photoacoustic determination of glucose concentration in whole blood by a near-infrared laser diode (2001)

The near-infrared photoacoustic technique is recognized as a potential method for the non-invasive determination of human glucose, because near-infrared light can incident a few millimeters into human tissue, where it produces an acoustic wave capable of carrying information about the composition of the tissue. This paper demonstrates a photoacoustic glucose measurement in a blood sample as a step toward a non-invasive measurement. The experimental apparatus consists of a near-infrared laser diode operating with 4 micro joules pulse energy at 905 nm, a roller pump connected to a silicon plastic tube and a cuvette for circulating the blood sample. In addition, the apparatus comprises a PZT piezoelectric transducer integrated with a battery-powered preamplifier to receive the photoacoustic signal. During the experiment, a glucose solution is mixed into a human blood sample to change its concentration. Although the absorption coefficient of glucose is much smaller than that of blood in the near-infrared region, the osmotic and hydrophilic properties of glucose decrease the reduced scattering coefficient of blood caused by the dissolved glucose surrounding the blood cells. This changes the distribution of the absorbed optical energy in blood, which, in turn, produces a change in the photoacoustic signal. Our experiment demonstrates that signal amplitudes in fresh and stored blood samples in crease about 7% and 10%, respectively, when the glucose concentration reaches the upper limit of the physiological region (500 mg/dl).
PI(3)King Apart PTEN's Role in Cancer (2010)

The tumor suppressor phosphatase and tensin homolog (PTEN) is a nonredundant phosphatase, counteracting one of the most critical cancer-promoting pathways: the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. In addition to the canonical function of dephosphorylation of phosphatidylinositol-3,4,5-trisphosphate (PIP3), recent studies showed the intriguing roles of PTEN in regulating genomic instability, DNA repair, stem cell self-renewal, cellular senescence, and cell migration and/or metastasis. Clinically, PTEN mutations and deficiencies are prevalent in many types of human cancers. Severe PTEN deficiency is also associated with advanced tumor stage and therapeutic resistance, such as the resistance to trastuzumab, an anti-HER2 therapy. Currently, targeting the deregulated PI3K/PTEN-Akt signaling axis has emerged as one of the major tenets in anticancer drug development. In this review, we highlight our current knowledge of PTEN function and the recent discoveries in dissecting the PTEN signaling pathway. The deregulations of PTEN in cancers, clinical lessons, and new prospects of rationally designed PI3K/Akt-targeted therapy for effective cancer treatment are also discussed.
Relaxation Distribution Function of Intracellular Dielectric Zones as an Indicator of Tumorous Transition of Living Cells (1991)

The response decay data of living cells subject to electric polarization is associated with their relaxation distribution function (RDF) and can be determined using the inverse Laplace transform method. A new polynomial, involving a series of associated Laguerre polynomials, has been used as the approximating function for evaluating the RDF, with the advantage of avoiding the usual arbitrary trial values of a particular parameter in the numerical computations. Some numerical examples are given, followed by an application to cervical tissue. It is found that the average relaxation time and the peak amplitude of the RDF exhibit higher values for tumorous cells than normal cells and might be used as parameters to differentiate them and their associated tissues.
Separation of the α Chains of Type I and III Collagens by SDS-Polyacrylamide Gel Electrophoresis1 (1979)

A method for the separation of type III collagen from type I collagen by SDS-polyacrylamide gel electrophoresis has been developed. This is based on the observation that the presence of 3-4 M urea decreases the mobility of the alpha 1 [III] chain to a greater extent than those of the alpha 1[I] and alpha 2 chains, although the alpha 1[I] and alpha 1[III] chains move at the same rate in the absence of urea. An attempt to separate the alpha 1[II] chain of type II collagen from the alpha 1[I] chain was unsuccessful under the experimental conditions employed.
Performance of a total-flow impulse turbine for geothermal applications (1977)

A new, axial-flow impulse turbine was tested at LLL as part of the geothermal energy development program. Engine efficiency of this single-stage, two-phase expander was measured at 23% during a single-nozzle test. Performance predictions of a numerical model agreed with these results. Full-admission performance (based on the numerical-model and attainable nozzle thrust coefficients) indicates that engine efficiency can reach between 38 and 40% with present technology. Improved techniques for analyzing two-phase flow and further reduction of droplet sizes should provide 70% engine efficiency.
The Internet and the World Wide Web (2002)

This tutorial shows you how to unlock the hidden resources of the Internet and the World Wide Web. After a description of its history, we demystify the Internet's terminology and procedures by exploring electronic mail, addressing, mail lists, news groups, and the World Wide Web. We illustrate Web use in two domains, personal and professional. In the personal domain we show a number of useful, time-saving resources for: travel and leisure, investments and finance; personal shopping; medicine; real estate; museums; weather; games; and finding, retrieving, and managing information on any topic whatsoever. In the professional domain we show how to access Web resources in such areas as elementary, secondary, and university-level education; computers; legal advice; libraries; news and current events; science and engineering; telecommunications, teleconferencing, telemedicine, and telecommuting. We close with a review of the "hot topics" of 1997: privacy and security, electronic payment systems, and low-cost and high speed Internet access.
Knowledge, learning, and freedom from thought (2018)

This chapter discusses the acquisition of knowledge by one generation from another, and the problems inherent in the process. The difficulties are seen as falling into three areas: (i) the difficulty of understanding the knowledge itself; (ii) the difficulty that a fact or a theory becomes an internal object subject to all the vicissitudes of object relations; and (Hi) the difficulty of finding a training method that will enable the learner to assimilate knowledge and use it judiciously rather than to swallow it an uncomprehending way. Examples are drawn from the history of ideas in generaland from the author’s experience of therapeutic communities, particularly the Cassel Hospital. The danger of allowing a body of knowledge to become, in its passage from one person to another, a mere set of never-to-be-questioned beliefs is illustrated. The common frailties of both trainers and trainees are discussed and methods suggested for understanding and overcoming them.
FULLY BATCH-FABRICATED MEMS MAGNETIC VIBRATIONAL ENERGY HARVESTERS (2009)

This paper reports the fabrication and characterization of fully-integrated, fully-batch-microfabricated electromagnetic vibrational energy harvesters. The 4 - 15 mm 3 structures utilize embedded NdFeB powder micromagnet technology, and represent some of the smallest magnetic energy harvesters demonstrated to date. Of three different designs, the best performing demonstrated 13.2 μVrms at the device resonance of 530 Hz and 1 g (9.8 m/s 2 ) excitation. This corresponds to a predicted maximum output power of 23 pW and a normalized power density of 1.6 ×10 -9 W/cm 3 ·g 2 . While the power from these prototype devices is limited, ongoing design and fabrication improvements aim to increase their performance.
Les récepteurs des lipoprotéines vieilles connaissances et nouveaux venus (1997)

SCOPUS: ar.j
H.G. Gadamer (2002)

En la cultura moderna y contemporanea, aumenta considerablemente el problema hermeneutico. Pero la propia hermeneutica contemporanea afirma que existir es interpretar, por lo que en todas las epocas se ha dado el esfuerzo hermeneutico. El hombre siempre se ha encontrado con problemas interpretativos, con la necesidad de remitir determinados signos a su significado, y de construir una metodologia que se ocupe de los significados oscuros de los mensajes humanos. Pero rigurosamente, la hermeneutica es una disciplina que nace en la modernidad, y que solo en los ultimos siglos se organiza como disciplina autonoma y como teoria filosofica general. Hermeneutica viene del griego, hermeneia (sermo en latin), e indica la eficacia de la expresion linguistica. Al principio, la hermeneutica estuvo unida a la experiencia de transmitir mensajes (Hermes, el mensajero de los dioses), surgiendo en Grecia bajo la forma del arte de los poetas y los oraculos, portavoces de los dioses. En seguida llego a significar interpretacion de documentos, pero en el mundo antiguo no tuvo relevancia filosofica. Para Platon, la hermeneutica es una pseudociencia, que no transmite autentica verdad y sabiduria. El De interpretatione de Aristoteles, aunque desarrolla una teoria del significado, no presenta conexiones directas con el sentido especifico del termino. Si son mas relevantes para esta prehistoria de la hermeneutica las investigaciones de los filosofos alejandrinos sobre los sentidos de un escrito. Tambien son interesantes los esfuerzos de los Padres de la Iglesia en la interpretacion de la Biblia, aunque la escolastica no aprovecha este esfuerzo para dar un impulso a nuestra disciplina. Solo en el Renacimiento la hermeneutica comienza a surgir como disciplina particular, aunque sigue ligada a la exegesis de los textos sagrados. En el XVIII se produce el giro universalistico de la hermeneutica, y esta pasa a ocuparse, no solo de la Biblia, sino de todo tipo de textos. Sus representantes mas significativos son Chladenius, Friedrich Meier y sobre todo Schleiermacher, precursor romantico de la hermeneutica actual. Schleiermacher (1768-1834) identifica la interpretacion con la comprension de todo texto cuyo sentido no sea evidente y constituya un problema, subrayado por algun tipo de distancia que se impone entre nosotros y el texto. De este autor la hermeneutica actual hereda el principio de entender el discurso ante todo tan bien o mejor de cuanto lo hubiera entendido el autor mismo. Tambien encontramos: • La idea de un reenvio circular entre parte y todo. • La concepcion de la hermeneutica como reproduccion creativa del pasado. • La tesis del caracter interpretativo implicito en todo saber historico. • El lenguaje como unico presupuesto de la hermeneutica.