gebhart/patrepeval huggingface dataset:
A study of natural killer cell lectin‐like receptor K1 gene (KLRK1/NKG2D) region polymorphisms in a European population sample (2009)

Recent evidence has reinforced the belief in immunosurveillance as a powerful mechanism against cancer development. The natural killer (NK) cell has been recognized as a potent agent of cancer immunosurveillance. A Japanese cohort study correlated natural cytotoxic activity levels with subsequent cancer development and identified NK cell lectin-like receptor K1 gene (KLRK1/NKG2D) polymorphisms as genetic markers of cancer predisposition. In the present study, we genotyped 82 reference cell lines and 388 newborn samples at 10 KLRK1 region variants by TaqMan((R)) allelic discrimination assays and showed that the same polymorphisms occur at similar frequencies in Europeans. The same haplotype block that has been associated with lower natural cytotoxic activity also occurred with the highest frequency in our sample. We further detected evidence suggestive of natural selection at some of the loci analyzed and more importantly, sex specificity of this selection. It appeared that heterozygosity at loci forming a haplotype block was unfavorable for boys. Given the relevance of NK cells in fetal survival, this finding has potential implications in the study of genetics of maternofetal recognition. Our preliminary findings are of marginal statistical significance and should be replicated in a larger sample. We believe that our results will increase awareness of the involvement of KLRK1 in cancer immunosurveillance and possibly in prenatal selection.
Isolation of an Adenovirus and an Adeno-Associated Virus from Goat Kids with Enteritis (2004)

A dairy goat operation in Minnesota experienced a sudden, markedly increased mortality among its neonatal goats. Approximately 60 of 130 kids (46%) died. The animals had diarrhea and dyspnea of 1-2 days duration before death. Necropsy of 4 goat kids revealed marked, acute, catarrhal enteritis and fibrinous pleuropneumonia. Mannheimia haemolytica was isolated from the lungs. Basophilic inclusion bodies filling the entire nucleus were present in enterocytes of the ileum of 3 goats. Adenoviral particles were detected in the feces by electron microscopy and adenovirus was subsequently isolated from the intestinal content together with a parvo-like virus (dependovirus). Morphology, physicochemical characteristics, and neutralization tests indicated that the adenovirus resembled ovine adenovirus-2 (OAdV-2). However, the PstI restriction endonuclease pattern produced by the goat adenovirus was distinct from that of OAdV-2. This is the first report of enteritis in goats with an adenovirus antigenically related to OAdV-2 and with a parvo-like dependovirus.
Gemcitabine versus Modified Gemcitabine: A Review of Several Promising Chemical Modifications (2012)

Gemcitabine, an anticancer agent which acts against a wide range of solid tumors, is known to be rapidly deaminated in blood to the inactive metabolite 2',2'-difluorodeoxyuridine and to be rapidly excreted by the urine. Moreover, many cancers develop resistance against this drug, such as loss of transporters and kinases responsible for the first phosphorylation step. To increase its therapeutic levels, gemcitabine is administered at high doses (1000 mg/m(2)) causing side effects (neutropenia, nausea, and so forth). To improve its metabolic stability and cytotoxic activity and to limit the phenomena of resistance many alternatives have emerged, such as the synthesis of prodrugs. Modifying an anticancer agent is not new; paclitaxel or ara-C has been subjected to such changes. This review summarizes the various chemical modifications that can be found in the 4-(N)- and 5'-positions of gemcitabine. They can provide (i) a protection against deamination, (ii) a better storage and (iii) a prolonged release in the cell, (iv) a possible use in the case of deoxycytidine kinase deficiency, and (v) transporter deficiency. These new gemcitabine-based sysems have the potential to improve the clinical outcome of a chemotherapy strategy.
Two isoﬂavones and bioactivity spectrum of the crude extracts of <i>Iris germanica</i> rhizomes (2003)

In vitro biological activities including bactericidal, fungicidal and insecticidal activities as well as phytotoxicity and brine shrimp toxicity of the petroleum ether, chloroform and ethyl acetate extracts of Iris germanica L. were determined. The bactericidal activity of the extracts was assayed by the agar well diffusion test. In the fungicidal test, the agar tube dilution method was used. The insecticidal activity was determined by the exposure method. The toxicity of the extracts was evaluated by the phytotoxicity test as well as the brine shrimp toxicity test. The chloroform and ethyl acetate extracts of I. germanica rhizomes exhibited bactericidal activity, while the petroleum ether extract did not exhibit any bactericidal, fungicidal and insecticidal activities. It was also inactive in the brine shrimp toxicity test, whereas it showed significant phytotoxicity against the plant Lemna aequinoctialis Welv. Two known isoflavones were isolated from the chloroform extract of the plant.
Training and testing of recommender systems on data missing not at random (2010)

Users typically rate only a small fraction of all available items. We show that the absence of ratings carries useful information for improving the top-k hit rate concerning all items, a natural accuracy measure for recommendations. As to test recommender systems, we present two performance measures that can be estimated, under mild assumptions, without bias from data even when ratings are missing not at random (MNAR). As to achieve optimal test results, we present appropriate surrogate objective functions for efficient training on MNAR data. Their main property is to account for all ratings - whether observed or missing in the data. Concerning the top-k hit rate on test data, our experiments indicate dramatic improvements over even sophisticated methods that are optimized on observed ratings only.
User-sensitive scheduling of home appliances (2011)

Demand response (DR) programs encourage end-use customers to alter their power consumption in response to DR events such as change in real-time electricity prices. Facilitating household participation in DR programs is essential as the residential sector accounts for a sizable portion of the total energy consumed. However, manually tracking energy prices and deciding on how to schedule home appliances can be a challenge for residential consumers who are accustomed to fixed price electricity taris. In this work, we present Yupik, a system that helps users respond to real-time electricity prices while being sensitive to their context and lifestyle. Yupik combines sensing, analytics, and optimization to generate appliance usage schedules that may be used by households to minimize their energy bill as well as potential lifestyle disruptions. Yupik uses jPlugs, appliance level energy metering devices, to continuously monitor the power usage by various home appliances. The consumption patterns as well as data from external sources are analyzed using data mining algorithms to infer user's preferred usage profile. Using the preferred profile as a reference, Yupik's optimization engine generates multiple usage plans that attempt to minimize energy and inconvenience costs. Some of Yupik's capabilities are demonstrated with the help of preliminary data collected from a home that was instrumented with jPlugs to monitor the power usage of a few devices.
Critical Review of Intelligent Battery Systems: Challenges, Implementation, and Potential for Electric Vehicles (2021)

This review provides an overview of new strategies to address the current challenges of automotive battery systems: Intelligent Battery Systems. They have the potential to make battery systems more performant and future-proof for coming generations of electric vehicles. The essential features of Intelligent Battery Systems are the accurate and robust determination of cell individual states and the ability to control the current of each cell by reconfiguration. They enable high-level functions like fault diagnostics, multi-objective balancing strategies, multilevel inverters, and hybrid energy storage systems. State of the art and recent advances in these topics are compiled and critically discussed in this article. A comprising, critical discussion of the implementation aspects of Intelligent Battery Systems complements the review. We touch on sensing, battery topologies and management, switching elements, communication architecture, and impact on the single-cell. This review contributes to transferring the best technologies from research to product development.
Silica-based optical integrated circuits (1996)

Silica-based integrated optical waveguide technology is reviewed. Low loss and manufacturable waveguides are made by chemical vapour, flame hydrolysis and electron beam deposition. Fibre to fibre insertion loss is as low as 0.3 dB for a 6 cm long waveguide. Bragg reflective add-drop filters are made with gratings formed by ultraviolet irradiation. The waveguide grating router has found important application as a multiplexer in dense wavelength multiplexed communications systems. Multiplexers with wide pass bands and stop bands are made with Fourier filters: these filters consist of a chain of alternating couplers and delaying arms. The good performance of waveguide grating routers and Fourier filters is due to the high degree of path delay and coupler control achievable by photolithography and processing in this technology.
Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era (2010)

In the modern management era, idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension remains a progressive, fatal disease. Mortality is most closely associated with male gender, right ventricular hemodynamic function, and exercise limitation.
Preferential Solvation in Carbonyl-Twisted PRODAN Derivatives (2013)

The Rosés and Bosch model for preferential solvation is used to analyze the fluorescence behavior of two PRODAN derivatives in binary solvents with one or two protic components. The preferential solvation results suggest that the excited PRODAN derivatives form two H-bonds. The model allows for determining the characteristics of the singly H-bonded excited states. They show red-shifted fluorescence but relatively little quenching. In contrast, the doubly H-bonded excited states are significantly quenched when the protic solvent is a strong H-bond donor (large SA value). With two protic solvents there is little preferential interaction even though the solvents have very different H-bond-forming ability.
Halogenated quinolines discovered through reductive amination with potent eradication activities against MRSA, MRSE and VRE biofilms (2015)

Small molecules capable of eradicating non-replicating bacterial biofilms are of great importance to human health as conventional antibiotics are ineffective against these surface-attached bacterial communities. Here, we report the discovery of several halogenated quinolines (HQs) identified through a reductive amination reaction that demonstrated potent eradication of MRSA (HQ-6; MBEC = 125 μM), MRSE (HQ-3; MBEC = 3.0 μM) and VRE (HQ-4, HQ-5 and HQ-6; MBEC = 1.0 μM) biofilms. HQs were evaluated using the Calgary Biofilm Device (CBD) and demonstrated near equipotent killing activities against planktonic and biofilm cells based on MBC and MBEC values. When tested against red blood cells, these HQ analogues demonstrated low haemolytic activity (3 to 21% at 200 μM) thus we conclude that these HQ analogues do not operate primarily through the destruction of bacterial membranes, typical of other biofilm-eradicating agents (i.e., antimicrobial peptides). HQ antibacterial agents are potent biofilm-eradicating compounds and could lead to useful treatments for biofilm-associated bacterial infections.
Designing reliable polymer coatings (1996)

Abstract A method to predict the ultimate adhesion performance of coatings subjected to biaxial, tensile stress is presented. A set of equations is developed to predict the onset of failure when the locus of failure is cohesive in the coating. The equations also have been extended to predict fatigue lifetime when a coating is cycled from a low temperature to room temperature. To test these equations, the Edge Liftoff Test (ELT) was developed. It consists of fabricating coatings of various heights on a rigid substrate and dicing the latter, so that the edges are 90° to the interface. The parts are cooled and the temperature of debonding is recorded. For thermal fatigue validation, cycles at which the first debond is observed are recorded. ELT results have been collected for a typical epoxy for both monotonic and cyclic cooling. The predictions are in agreement with results.
Production and Evaluation of REFe2-Nickel Composite Magnetostrictive Materials. (1979)

The objective was to produce a composite magnetostrictive material consisting of particles of the 'giant' magnetostrictive material, SmFe2, distributed within a pure nickel matrix, and to demonstrate a marked enhancement of the magnetostrictive properties of this composite compared to the properties of nickel.
Clinical observation of treating superficial scars in the face and neck with fractional laser (2008)

Objective To sum up the clinical experience of treating superficial scars in the face and neck with fractional laser and observe the curative effect.Methods The superficial scars caused by acne,incision,contusion and burn were treated with ActiveFX UltraPulse Encore fractional laser.The curative rate were evaluated.Results 50 patients were involved.The total curative rate after one time treatment was 62%.After laser treatment,the wound healing time was 5 ～14 days,mean 9 days.the complications including infection,hypertrophic scar,hyperpigmentation,depigmentation were seldom occurred.Conclusion Treating the superficial scar in the face and neck with fractional laser can achieve satisfactory effect.
Optimizing inter-FPGA communication by automatic channel adaptation (2012)

Tightly coupled multi-FPGA architectures gain more and more interest in various application areas, like prototyping MPSoC, code breaking, or artificial neural networks, just to name a few. Communication protocols and implementations have to deal with rising clock frequencies on the one hand and short time to market demands on the other hand. These tight schedules and limited routing areas often lead to PCB routing which is not ideal in terms of length matching and therefore introduces different delays in parallel transmission lines. Crosstalk, impedance mismatch, and jitter further deteriorate the quality of the received signal. In order to achieve optimum data rates modern FPGAs offer different mechanisms to adapt to the behavior of the channel. This paper introduces a communication protocol and an architecture which evaluates the channel delays and automatically generates the configuration for the different mechanisms offered by the used FPGAs. The protocol supports several transmission standards and can be scaled to different physical and virtual channel widths.
The satiety hormone peptide YY as a regulator of appetite (2008)

Obesity is a major cause of premature death in the UK, and may contribute to as many as 30 000 deaths a year in the UK. Although effective treatment for obesity is still awaited, many developments have occurred to improve our understanding of neuroendocrine regulation of food intake and weight gain, especially regarding the role of gut hormones. One such gut hormone is peptide tyrosine-tyrosine also known as PYY where Y depicts the abbreviation for tyrosine. PYY is a 36 amino acid hormone, first isolated from porcine intestine. PYY, along with few other gut hormones, has been suggested as a potential therapeutic agent for obesity. This review examines the relationship of PYY to appetite regulation, energy homeostasis and the relevant neuroendocrine feedback mechanism.
Multiple mRNA species generated by alternate polyadenylation from the rat manganese superoxide dismutase gene (1992)

The mitochondrial enzyme, manganese superoxide dismutase (MnSOD) is an integral component of the cell's defense against superoxide-mediated cellular damage. We have isolated and characterized four cDNA clones and the structural gene for rat MnSOD. Northern analyses using MnSOD cDNA probes detected at least five mRNAs in all tissues and cell types examined. Southern and Northern analysis using a 3' non-coding sequence probe, common to all the cDNAs, showed hybridization only to genomic restriction fragments that correspond to our genomic clone and the five MnSOD mRNAs. These data demonstrate that all of the rat MnSOD transcripts are derived from a single functional gene. Primer extension data indicate that transcription initiation is clustered within a few bases. Northern analysis using intron probes demonstrates that all five transcripts are fully processed. Northern analysis using cDNA and genomic probes from sequences progressively 3' to the end of the coding sequence indicates that size heterogeneity in the MnSOD transcripts results from variations in the length of the 3' non-coding sequence. From this data and the location of potential polyadenylation signals near the expected sites of transcript termination, we conclude that the existence of multiple MnSOD mRNA species originate as the result of alternate polyadenylation.
Increase in Ca2+ channel expression by deletions at the amino terminus of the cardiac alpha 1C subunit. (1996)

The alpha 1 subunit of the cardiac L-type Ca2+ channel (alpha 1C) is one of the many alternatively spliced products of a single gene that is expressed in a number of excitable tissues. Sequence comparison indicates that the amino terminus is a site of significant structural diversity. To explore the role of the amino terminus of alpha 1C in expression and function of Ca2+ channels, we constructed a series of deletion mutants of the rabbit cardiac alpha 1C subunit and expressed them in Xenopus oocytes. Deletions of up to 120 amino acids from the amino terminus increased both ionic and gating currents by 5- to 8-fold. Ca2+ currents induced by these mutants had voltage-dependent activation, inactivation, modulation by beta subunits, and single channel conductance similar to the wild type cardiac alpha 1C (wt alpha 1C). Thus, deletion of a major portion of the amino terminus of alpha 1C did not alter the three dimensional conformation essential for channel function, but enhanced the expression of Ca2+ channels in Xenopus oocytes. A deletion mutant lacking the first 171 amino acids did not yield any measurable current.
Rationality : why social context matters (1996)

Rationality is commonly identified with axioms and rules, such as consistency, which are defined without reference to context, but are imposed in all contexts. In this chapter, I focus on the social context of rational behavior. My thesis is that traditional axioms and rules are incomplete as behavioral norms in the sense that their normative validity depends on the social context of the behavior, such as social objectives, values, and motivations. In the first part, I illustrate this thesis by showing that social context can determine whether an axiom or rule is satisfied or not. In the second part, I describe an alternative to context-independent rationality: a domain-specific theory of rational behavior derived from the evolutionary theory of cooperation.
Comparison of whole genome assemblies of the human genome (2002)

A fundamental problem in the human genome project is uncovering the correct assembly of the human genome. Many studies, including transcriptional analysis, SNP detection and characterization, gene finding and EST clustering, use genome assemblies as templates so it is important to determine the consistency among the various whole genome assemblies. A comparison of the order and orientation of the GenBank entries used to construct the NCBI and UCSC Goldenpath assemblies was made. In addition, a sequence level comparison was performed using MULTI, an efficient database search tool developed to make whole genome comparisons possible. The resulting comparisons show significant discrepancies in the sequence as well as in the order and orientation of GenBank entries used in constructing the NCBI and UCSC assemblies.
A real-time approach for autonomous detection and tracking of moving objects from UAV (2014)

A new approach to autonomously detect and track moving objects in a video captured by a moving camera from a UAV in real-time is proposed in this paper. The introduced approach replaces the need for a human operator to perform video analytics by autonomously detecting moving objects and clustering them for tracking purposes. The effectiveness of the introduced approach is tested on the footage taken from a real UAV and the evaluation results are demonstrated in this paper.
Characterization of Fv Fragments Expressed on Phage Surface (1998)

We characterized a phage antibody in which an Fv fragment, namely, a free VH fragment noncovalently associated with a VL fragment that is fused with a truncated cpIII molecule (VL-DeltacpIII), is expressed on the phage surface. D1.3 antibody specific for hen egg-white lysozyme was used as a model system. Both VH and VL-DeltacpIII fragments were stably expressed and associated with each other to form a faithful antigen-binding site. The results of Western blotting indicated that more than 5% of phages expressed the Fv fragment on their surface. Analysis of the kinetics of binding of the phage antibody to the antigen suggested the possibility of presence of phages having multiple-binding sites on a single phage particle.
Effect of deficit irrigation on anthocyanin content of Monastrell grapes and wines (2005)

<p style="text-align: justify;">The results showed that moderately irrigated vines produced berries with a higher anthocyanin content (expressed as mg/100 berries) than non-irrigated vines. These findings suggest that moderate levels of water doses may actually improve the physiological status of vines grown in very dry areas, resulting in higher yields and higher quality grapes. The higher yields were mainly related to larger berry size which led to a lower anthocyanin content when expressed as mg/kg, due to a dilution effect. This fact is also responsible for the lower anthocyanin content of the wines elaborated with grapes from irrigated vines although irrigation per se did not decrease the concentration of anthocyanins in grapes.</p>
Ultrasound extended-field-of-view imaging based on motion estimation using quaternion wavelet (2012)

In this paper, we propose a novel extended-field-of-view (EFOV) imaging algorithm based on the property of motion estimation in quaternion wavelet domain (QWD) for ultrasound images. Firstly, transform the ultrasound video frames into QWD from spatial domain, and the result consists of one magnitude and three phases. Secondly, use two phases to estimate the motion of image sequence derived from the shift theorem. We can obtain the motion vectors through motion estimation, and the registered images through the affine transform of the motion vectors. Thirdly, use the third phase with the magnitude to fuse the registered images. Finally, the ultrasound panoramic image is achieved by means of fusing the registered images. Finally, experiments are conducted to verify the performances of the proposed algorithm.