gebhart/patrepeval huggingface dataset:
Optical techniques to feed and control GaAs MMIC modules for phased array antenna applications (1986)

A complex signal distribution system is required to feed and control GaAs monolithic microwave integrated circuits (MMICs) for phased array antenna applications above 20 GHz. Each MMIC module will require one or more RF lines, one or more bias voltage lines, and digital lines to provide a minimum of 10 bits of combined phase and gain control information. In a closely spaced array, the routing of these multiple lines presents difficult topology problems as well as a high probability of signal interference. To overcome GaAs MMIC phased array signal distribution problems optical fibers interconnected to monolithically integrated optical components with GaAs MMIC array elements are proposed as a solution. System architecture considerations using optical fibers are described. The analog and digital optical links to respectively feed and control MMIC elements are analyzed. It is concluded that a fiber optic network will reduce weight and complexity, and increase reliability and performance, but higher power will be required.
Subluminal group velocity and dispersion of Laguerre Gauss beams in free space (2016)

That the speed of light in free space c is constant has been a pillar of modern physics since the derivation of Maxwell and in Einstein's postulate in special relativity. This has been a basic assumption in light's various applications. However, a physical beam of light has a finite extent such that even in free space it is by nature dispersive. The field confinement changes its wavevector, hence, altering the light's group velocity vg. Here, we report the subluminal vg and consequently the dispersion in free space of Laguerre-Gauss (LG) beam, a beam known to carry orbital angular momentum. The vg of LG beam, calculated in the paraxial regime, is observed to be inversely proportional to the beam's divergence θ0, the orbital order ℓ and the radial order p. LG beams of higher orders travel relatively slower than that of lower orders. As a consequence, LG beams of different orders separate in the temporal domain along propagation. This is an added effect to the dispersion due to field confinement. Our results are useful for treating information embedded in LG beams from astronomical sources and/or data transmission in free space.
Design of a temperature-independent Arrayed Waveguide Grating on SOI Substrates (2007)

In this paper, a Si-based temperature-independent AWG designed by a combination of a narrow and wide part in each Si waveguide on SOI substrates is proposed. The thermal effects on the proposed AWG is simulated and showed that it is possible to make the center wavelength be temperature-independent by adjusting the waveguide parameters.
Photothermal Initiation of Frontal Polymerization Using Carbon Nanoparticles (2020)

Frontal polymerization (FP) involves the rapid conversion of monomer into polymer within a moving reaction zone. The front is typically initiated with a thermal stimulus, but noncontact, remote initiation with light is attractive for applications where direct heating is not feasible. Here, we demonstrate efficient conversion of light into localized heat using carbon nanoparticles to accomplish photothermal initiation of FP. The addition of 1 wt % carbon black to dicyclopentadiene monomer results in a 10-fold increase in temperature rise from photothermal heating and a 30-fold decrease in energy input required for photothermal FP initiation. The energy input is further reduced by using carbon nanotubes and nanofibers. This photothermal initiation approach is expected to be applicable to other FP systems.
THE EFFECT OF E TYPE PROSTAGLANDINS ON THE PROLIFERATION OF HAEMOPOIETIC STEM CELLS <i>IN VIVO</i> (1977)

ABSTRACT The ability of protaglandins E 1 and E 2 to stimulate the proliferation of haemopoietic stem cells (CFU s ) was studied in vivo. PGE 2 , in a dose range of 10 ‐4 to 10 ‐1 μg/g body weight and PGE 1 in a dose range of 10 ‐5 to 10 ‐1 μg/g body weight, produced a rapid cycling wave of CFU s . The increase in the number of CFU s in S phase was not followed by a rise in the femoral CFU s content, and except for a transient increase in femoral CFU c level, no increase in differentiation was found either. Therefore, it is proposed that haemopoiesis after PG‐induced CFU stimulation is ineffective. PGE 2 did not stimulate regeneration of CFU s in a perturbed state (after sublethal irradiation). All these findings support the idea that PGEs might represent potent stimulators of the haemopoietic stem cells acting in physiological doses. However, if acting concurrently with physiological control systems PGs lead to ineffective haemopoiesis (under normal conditions) or do not exert any measurable effect (after sublethal irradiation).
Vibrotactile Perception of Segmental Features of Speech (1988)

This experiment compared the recognition performance of artificially deafened listeners for segmental stimuli presented through a single-channel tactile device and through a 24-channel vocoder. Both consonant and vowel stimuli were tested under visual only, tactile only, and visual + tactile conditions. Each subject received a pretest, eight 2-hr training sessions, and a posttest. Results indicated no significant differences between subject's overall recognition performance with two different tactile devices. Analysis of consonant confusions showed that both devices transmit the features of voicing, manner, and place of articulation in a similar fashion. In contrast to an earlier study on suprasegmental features by Carney and Beachler (1986), these results do not support the notion that preservation of the waveform envelope of speech is necessary for the transmission of segmental features of speech. These results also suggest that tactile perception of segmental features may not be altered significantly by the tactile array chosen.
Hepatocyte‐Specific Delivery of siRNAs Conjugated to Novel Non‐nucleosidic Trivalent <i>N</i>‐Acetylgalactosamine Elicits Robust Gene Silencing in Vivo (2015)

We recently demonstrated that siRNAs conjugated to triantennary N-acetylgalactosamine (GalNAc) induce robust RNAi-mediated gene silencing in the liver, owing to uptake mediated by the asialoglycoprotein receptor (ASGPR). Novel monovalent GalNAc units, based on a non-nucleosidic linker, were developed to yield simplified trivalent GalNAc-conjugated oligonucleotides under solid-phase synthesis conditions. Synthesis of oligonucleotide conjugates using monovalent GalNAc building blocks required fewer synthetic steps compared to the previously optimized triantennary GalNAc construct. The redesigned trivalent GalNAc ligand maintained optimal valency, spatial orientation, and distance between the sugar moieties for proper recognition by ASGPR. siRNA conjugates were synthesized by sequential covalent attachment of the trivalent GalNAc to the 3'-end of the sense strand and resulted in a conjugate with in vitro and in vivo potency similar to that of the parent trivalent GalNAc conjugate design.
Cofilin recruitment and function during actin-mediated endocytosis dictated by actin nucleotide state (2007)

Cofilin is the major mediator of actin filament turnover in vivo. However, the molecular mechanism of cofilin recruitment to actin networks during dynamic actin-mediated processes in living cells and cofilin's precise in vivo functions have not been determined. In this study, we analyzed the dynamics of fluorescently tagged cofilin and the role of cofilin-mediated actin turnover during endocytosis in Saccharomyces cerevisiae. In living cells, cofilin is not necessary for actin assembly on endocytic membranes but is recruited to molecularly aged adenosine diphosphate actin filaments and is necessary for their rapid disassembly. Defects in cofilin function alter the morphology of actin networks in vivo and reduce the rate of actin flux through actin networks. The consequences of decreasing actin flux are manifested by decreased but not blocked endocytic internalization at the plasma membrane and defects in late steps of membrane trafficking to the vacuole. These results suggest that cofilin-mediated actin filament flux is required for the multiple steps of endocytic trafficking.
Immunosuppressive actions of retroviruses. (1990)

The immunosuppressive properties of retroviruses were first demonstrated by Old et al. We later showed that Gross Passage A retrovirus superinfection in mice resulted in decreased antibody production and diminished allograft rejection. We have studied in some detail the immunosuppression which occurs subsequent to infection with feline leukemia virus (FeLV) as characterized by profoundly depressed T and B lymphocyte responses and decreased production of gamma-interferon. Injection of staphylococcal protein A (SPA) corrected these deficient immune responses, cleared circulating FeLV from blood and produced a regression of FeLV-induced lymphomas and leukemias. The immunosuppressive properties of FeLV and certain other retroviruses have been linked to the transmembrane viral envelope peptide, p15E. Cianciolo et al synthesized a 17-amino acid viral component which shares sequence homology with a highly conserved region of p15E. In vitro analyses have shown that this synthetic retroviral peptide suppresses T and B cell functions, inhibits the generation of cytotoxic lymphocyte (CTL) responses and dramatically alters the morphology and distribution of monocytes. The latter finding, along with reports that cells of the monocyte/macrophage lineage play a critical role in the initiation of human immunodeficiency infection, suggests that monocytes and macrophages may play a crucial role in retroviral infection and some of the associated immunodeficiencies associated with retroviral infection.
Recent trends in the gene therapy of &beta;-thalassemia (2015)

The β-thalassemias are a group of hereditary hematological diseases caused by over 300 mutations of the adult β-globin gene. Together with sickle cell anemia, thalassemia syndromes are among the most impactful diseases in developing countries, in which the lack of genetic counseling and prenatal diagnosis have contributed to the maintenance of a very high frequency of these genetic diseases in the population. Gene therapy for β-thalassemia has recently seen steadily accelerating progress and has reached a crossroads in its development. Presently, data from past and ongoing clinical trials guide the design of further clinical and preclinical studies based on gene augmentation, while fundamental insights into globin switching and new technology developments have inspired the investigation of novel gene-therapy approaches. Moreover, human erythropoietic stem cells from β-thalassemia patients have been the cellular targets of choice to date whereas future gene-therapy studies might increasingly draw on induced pluripotent stem cells. Herein, we summarize the most significant developments in β-thalassemia gene therapy over the last decade, with a strong emphasis on the most recent findings, for β-thalassemia model systems; for β-, γ-, and anti-sickling β-globin gene addition and combinatorial approaches including the latest results of clinical trials; and for novel approaches, such as transgene-mediated activation of γ-globin and genome editing using designer nucleases.
OS-level virtualization for industrial automation systems (2016)

Virtualization is entering the world of real-time embedded systems. Industrial automation systems, in particular, can benefit from what virtualization has to offer: flexible consolidation of applications on different hardware types and scales, extending the life-time of legacy code or decoupling software and hardware lifecycles. However, such systems require a light-weight virtualization technology in order to be able to maintain real-time behavior while dealing with real-time data. This paper sets out to investigate the applicability of container-based OS-level virtualization technology to industrial automation systems. To this end, we provide insights into the capabilities of containers to achieve flexible consolidation and easy migration of industrial automation applications as well as into the container technology readiness with respect to the fundamental requirement of industrial automation systems, namely performing timely control actions based on real-time data. Moreover, we provide an empirical study of the performance overhead introduced by containers based on micro-benchmarks that capture the characteristics of targeted industrial automation applications.
PSBIST: A partial-scan based built-in self-test scheme (2002)

Partial-scan based built-in self-test (PSBIST) is a versatile design for testability (DFT) scheme, which employs pseudo-random BIST at all levels of test to achieve fault coverages greater than 98% on average, and supports deterministic partial scan at the IC level to achieve nearly 100% fault coverage. While PSBIST provides all the benefits of BIST, it incurs less area overhead and performance degradation than full scan. The area overhead is further reduced when the boundary scan cells are reconfigured for BIST usage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Performance analysis of a deterministic channel estimator for block transmission systems with null guard intervals (2002)

A deterministic algorithm was proposed for channel identification in block communication systems. The method assumed that the channel has a finite impulse response (FIR) and that null guard intervals of length greater than the channel order are inserted between successive blocks to prevent interblock interference and allow block synchronization. In the absence of noise, the algorithm provides error-free channel estimates, using a finite number of received data, without requiring training sequences and without imposing a restriction neither on the channel, except for finite order and time invariance, nor on the symbol constellation. Using small perturbation analysis, we derive approximate expressions of the estimated channel covariance matrix, which are used to quantify the resilience of the estimation algorithm to additive noise and channel fluctuations. Specifically, we consider channel fluctuations induced by transmitter/receiver relative motion, asynchronism, and oscillators' phase noise. We also compare the channel estimation accuracy with the Cramer-Rao bound (CRB) and prove that our estimation method is statistically efficient at practical SNR values for any data block length. Finally, we validate our theoretical analysis with simulations and compare our transmission scheme with an alternative system using training sequences for channel estimation.
Three of a kind (2000)

With uninterruptible power supplies now used in critical applications across every industrial sector, a standard terminology to describe types and performance measures has become essential. The author outlines how the international standards community has responded to this need by introducing IEC 62040-3 which distinguishes three types of UPS topology: passive standby, line interactive, and double conversion. These three topologies are described. For low power ratings (less than 2 kVA) all three topologies, as defined by the standards, are used. For medium to high power ratings, the case for the passive standby and the line interactive is, at best, marginal, in spite of their significantly lower cost. The vast majority of sales to medium to high-power rating applications are represented by double conversion UPSs (95% from a few kVA upwards; 98% above 10 kVA). The dominance of the double-conversion topology is attributable to its almost total lack of weaknesses, combined with the capacity to meet the needs of sensitive loads at these power ratings-a consequence of UPS being connected in series with the utility power sources.
[Physiological characteristics of a low-pH tolerant strain Torulopsis glabrata RT-6]. (2011)

Discharging more intracellular H+ and inhibiting the intracellular H+ production contributed to the strain RT-6's higher intracellular pH, and therefore the acid tolerance.
Update on the management of chronic eczema: new approaches and emerging treatment options (2010)

Atopic dermatitis (AD) is a common disease with worldwide prevalence, affecting up to 20% of children and 3% of adults. Recent evidence regarding pathogenesis has implicated epidermal barrier defects deriving from filagrin mutations with resulting secondary inflammation. In this report, the authors comprehensively review the literature on atopic dermatitis therapy, including topical and systemic options. Most cases of AD will benefit from emollients to enhance the barrier function of skin. Topical corticosteroids are first-line therapy for most cases of AD. Topical calcineurin inhibitors (tacrolimus ointment, pimecrolimus cream) are considered second line therapy. Several novel barrier-enhancing prescription creams are also available. Moderate to severe cases inadequately controlled with topical therapy may require phototherapy or systemic therapy. The most commonly employed phototherapy modalites are narrow-band UVB, broadband UVB, and UVA1. Traditional systemic therapies include short-term corticosteroids, cyclosporine (considered to be the gold standard), methotrexate, azathioprine, mycophenolate mofetil, and most recently leflunamide. Biologic therapies include recombinant monoclonal antibodies acting on the immunoglobulin E / interleukin-5 pathway (omalizumab, mepolizumab), acting as tumor necrosis factor-α inhibitors (infliximab, etanercept, adalimumab), and acting as T-cell (alefacept) and B-cell (rituxumab) inhibitors, as well as interferon γ and intravenous immunoglobulin. Efficacy, safety, and tolerability are reviewed for each medication.
Phenol oxidation and biosynthesis. Part 27. Reactions of relevance to the formation of erysodienone in vitro (1979)

Potassium hexacyanoferrate(III) oxidation of N-(2-arylethyl)-2-arylacetamide and arylmethyl arylpropyl ketone gave the corresponding nine-membered ring derivatives formed by p,p-phenol oxidative coupling (where aryl was 3-hydroxy-4-methoxyphenyl). This strongly supports the previously reported mechanism for the in vitro formation of erysodienone. The required ketone was prepared from O-benzylisovanillin by homologation with toluene-4-sulphonylmethyl isonitrile.
Development and application of an autonomous unmanned aerial vehicle for precise aerobiological sampling above agricultural fields (2008)

Abstract Remote‐controlled (RC) unmanned aerial vehicles (UAVs) have been used to study the movement of agricultural threat agents (e.g., plant and animal pathogens, invasive weeds, and exotic insects) above crop fields, but these RC UAVs are operated entirely by a ground‐based pilot and often demonstrate large fluctuations in sampling height, sampling pattern, and sampling speed. In this paper, we describe the development and application of an autonomous UAV for precise aerobiological sampling tens to hundreds of meters above agricultural fields. We equipped a Senior Telemaster UAV with four aerobiological sampling devices and a MicroPilot‐based autonomous system, and we conducted 25 sampling flights for potential agricultural threat agents at Virginia Tech's Kentland Farm. To determine the most appropriate sampling path for aerobiological sampling above crop fields with an autonomous UAV, we explored five different sampling patterns, including multiple global positioning system (GPS) waypoints plotted over a variety of spatial scales. An orbital sampling pattern around a single GPS waypoint exhibited high positional accuracy and produced altitude standard deviations ranging from 1.6 to 2.8 m. Autonomous UAVs have the potential to extend the range of aerobiological sampling, improve positional accuracy of sampling paths, and enable coordinated flight with multiple UAVs sampling at different altitudes. © 2008 Wiley Periodicals, Inc.
Isoflavonoids and the other constituents in callus tissues of Pueraria lobata. (1982)

Puerarin, daidzin, daidzein, genistein, coumesterol, methyl 2, 4-dihydroxybenzoate, a mixture of methyl p-hydroxybenzoate and methyl trans-p-hydroxycinnamate, phytosterols and aliphatic acid esters were isolated from the methanol extract of callus tissues, which were induced from the stem of Pueraria lobata OHWI. The main products at the final stage of callus culture were daidzin and puerarin in the suspension culture and daidzin in the static culture. The quantitative changes of daidzin, puerarin and daidzein during the growth of callus tissues were investigated.
Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: Relevance to trypanosome lysis (2015)

Apolipoprotein L-1 (APOL1), the trypanolytic factor of human serum, can lyse several African trypanosome species including Trypanosoma brucei brucei, but not the human-infective pathogens T. brucei rhodesiense and T. brucei gambiense, which are resistant to lysis by human serum. Lysis follows the uptake of APOL1 into acidic endosomes and is apparently caused by colloid-osmotic swelling due to an increased ion permeability of the plasma membrane. Here we demonstrate that nanogram quantities of full-length recombinant APOL1 induce ideally cation-selective macroscopic conductances in planar lipid bilayers. The conductances were highly sensitive to pH: their induction required acidic pH (pH 5.3), but their magnitude could be increased 3,000-fold upon alkalinization of the milieu (pK(a) = 7.1). We show that this phenomenon can be attributed to the association of APOL1 with the bilayer at acidic pH, followed by the opening of APOL1-induced cation-selective channels upon pH neutralization. Furthermore, the conductance increase at neutral pH (but not membrane association at acidic pH) was prevented by the interaction of APOL1 with the serum resistance-associated protein, which is produced by T. brucei rhodesiense and prevents trypanosome lysis by APOL1. These data are consistent with a model of lysis that involves endocytic recycling of APOL1 and the formation of cation-selective channels, at neutral pH, in the parasite plasma membrane.
An algorithm for the detection of surface-active α helices with the potential to anchor proteins at the membrane interface (1997)

A new measure of membrane-interactive potential is proposed, called the depth-weighted inserted hydrophobicity (DWIH), which is based on the sequestration of hydrophobic residues within a hydrophobic compartment, such as that produced by a membrane bilayer. A statistical significance for this measure has been derived using Monte Carlo techniques. The algorithm is applied to a set of proteins which are thought to anchor to the membrane via C-terminal amphiphilic alpha helices. The DWIH measure appears to allow the identification of this category of membrane-interactive helices which lie near the boundary of the hydrophobic moment plot and which have previously been hard to classify.
The solvation of electrons by an atmospheric-pressure plasma (2015)

Solvated electrons are typically generated by radiolysis or photoionization of solutes. While plasmas containing free electrons have been brought into contact with liquids in studies dating back centuries, there has been little evidence that electrons are solvated by this approach. Here we report direct measurements of solvated electrons generated by an atmospheric-pressure plasma in contact with the surface of an aqueous solution. The electrons are measured by their optical absorbance using a total internal reflection geometry. The measured absorption spectrum is unexpectedly blue shifted, which is potentially due to the intense electric field in the interfacial Debye layer. We estimate an average penetration depth of 2.5 ± 1.0 nm, indicating that the electrons fully solvate before reacting through second-order recombination. Reactions with various electron scavengers including H(+), NO2(-), NO3(-) and H2O2 show that the kinetics are similar, but not identical, to those for solvated electrons formed in bulk water by radiolysis.