gebhart/patrepeval huggingface dataset:
Aromatic Plants from Western Cuba. V: Composition of the Leaf Oils of<i>Baccharis halimifolia</i>L. and<i>Eugenia foetida</i>(Sw.) Willd (2006)

Abstract The chemical composition of the leaf oils of Baccharis halimifolia L. and Eugenia foetida (Sw.) Willd. were studied by GC and GC/MS. Sixty-four compounds of the oil of B. halimifolia were identifed of which β-pinene (11.9%) was the major constituent. In the oil of E. foetida, 75 compounds were identifed of which caryophyllene oxide (14.8%) was the major component.
XXXV. Kongreß der Deutschen Gesellschaft für Innere Medizin in Wien, 9.—12. IV. 1923 (1923)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Nitrate Ions: Potentiation of Increased Permeability to Sugar Associated with Muscle Contraction (1967)

Nitrate ions potentiate twitch tension and enhance the increase in permeability to sugar which occurs in electrically stimulated frog sartorius muscles. However, the potentiating effect of nitrate ions on permeability is not dependent upon an increase in twitch tension. The possible relation of changes in permeability to alterations of the concentration of calcium ions in the cell is discussed.
Characterization of Proteolysis in Alfalfa and Red Clover (1995)

The loss of protein (proteolysis) during the ensiling of forage legumes is a severe problem. Alfalfa ( Medicago sativa L.) will lose 44 to 87% of its protein during ensiling, whereas red clover ( Trifolium pratense L.), a legume of similar protein content, will lose only 7 to 40%. Reasons for this difference in proteolysis are unknown. Research was conducted to determine and compare the general characteristics (rates, pH and temperature effects) of proteolysis in red clover and alfalfa extracts, and secondly to evaluate different in vitro test proteins to monitor legume proteolysis. Proteolytic rates of alfalfa and red clover extracts were not significantly different when either ribulose 1,5‐bisphosphate carboxylase/oxygenase (RubisCo) or bovine serum albumin (BSA) was used as the protein substrate; however, both legumes displayed significantly higher rates for the degradation of RubisCo than BSA (P < 0.10). The pH optima were 5.5 for both legumes when RubisCo was degraded, and 5.5 and 6 for alfalfa and red clover, respectively, when BSA was the substrate. Proteolysis in the legume extracts had similar pH and temperature stabilities and temperature optimum for the degradation of RubisCo. These data suggest that alfalfa and red clover have similar inherent proteolytic activity and cannot explain the difference in extent of proteolysis in the two silages.
The Psychology and Acoustics of Music (1942)

Research Article| August 01 1942 The Psychology and Acoustics of Music Arnold M. Small Arnold M. Small Search for other works by this author on: This Site PubMed Google Scholar Bulletin of the American Musicological Society (1942) 6: 15. https://doi.org/10.2307/829200 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Arnold M. Small; The Psychology and Acoustics of Music. Bulletin of the American Musicological Society 1 August 1942; 6 15. doi: https://doi.org/10.2307/829200 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentJournal of the American Musicological Society Search This content is only available via PDF. Copyright 1942 Arthur Mendel Article PDF first page preview Close Modal You do not currently have access to this content.
Molecular Sieve Membrane: Supported Metal–Organic Framework with High Hydrogen Selectivity (2009)

Molecular strainer: An ultramicroporous zeolitic imidazolate framework (ZIF-7) was tested for its gas-separation properties in membrane applications. ZIF-7 was appended to an asymmetric alumina support using microwave-assisted seeded growth, and the resulting ZIF-7 membrane exhibits high H2 selectivity as a molecular sieve and has excellent thermal stability.
Surface Acidity and Basicity of La<sub>2</sub>O<sub>3</sub>, LaOCl, and LaCl<sub>3</sub> Characterized by IR Spectroscopy, TPD, and DFT Calculations (2004)

Adsorption sites of La2O3, LaOCl, and LaCl3 catalysts were characterized with probe molecules using infrared spectroscopy, temperature-programmed desorption (TPD), and density-functional theory (DFT) calculations. Surface acid sites were probed with CO, pyridine, and 2,6-dimethylpyridine (DMP), and basic sites were probed with CO2. Shifts of the CO vibrational frequency at low surface coverage at 77 K suggest that the strength of Lewis acid sites increases with the concentration of Cl in the material; i.e., La2O3 < LaOCl < LaCl3. DFT estimates for CO adsorption energies and LUMO energies were consistent with this ranking. On the basis of a downward shift of the surface OH stretching bands interacting with CO, pyridine, and DMP spectra at room temperature (RT) and TPD results, and confirmed by DFT calculations, the strength of Brønsted acid sites was concluded to increase in the same order. Additional DFT calculations with a frequency analysis were used to elucidate CO2 adsorption modes. DFT calculations and IR spectra of CO2 adsorbed on LaOCl suggest that CO2 forms coupled bridged species. Proton affinity calculations were used to rank the basicity strength of surface O and Cl sites. The amount of CO2 adsorbed on LaCl3 was negligibly small, confirming the requirement of lattice O adsorption sites. IR spectra of CO2 adsorbed on La2O3 at RT were similar to those of bulk La2(CO3)3 and, accordingly, were assigned to the formation of polydentate and bulk carbonates. CO2 evolution from La2O3 in TPD experiments closely matched the reported thermal stability of La2(CO3)3.
The effects of prostaglandins on the intraocular pressure of the rabbit (1969)

1. The effects of intracameral injections of prostaglandins E(1), E(2), F(1a), F(2a), and A(1) were studied on the intraocular pressure (IOP) of rabbits anaesthetized with urethane.2. With the exception of prostaglandin F(1a), all the prostaglandins studied were found to be capable of producing a large, sustained rise in IOP, accompanied in many cases by miosis.3. A marked decrease in response to repeated injections was found with all the prostaglandins studied; this effect was more pronounced following a large initial response to the prostaglandin.4. The descending order of potency in their ability to raise IOP was as follows: prostaglandin E(1) approximately E(2)>F(2a)>A(1)>F(1a).5. Intracameral injections of prostaglandins E(1) and E(2) resulted in an increase in the protein content of the aqueous humour, which was related to the magnitude of the sustained increase in IOP.6. Stabilization of the blood-aqueous barrier with polyphloretin phosphate markedly reduced both the IOP response and the effect of prostaglandin E(2) on the protein content of the aqueous humour.7. It is concluded that the production of local vasodilatation and increased permeability of the blood-aqueous barrier play an important part in the effect of prostaglandins on the IOP. The involvement of prostaglandins in the response of the rabbit eye to irritation is discussed.
Copper/carbon nanotube composites: research trends and outlook (2018)

We present research progress made in developing copper/carbon nanotube composites (Cu/CNT) to fulfil a growing demand for lighter copper substitutes with superior electrical, thermal and mechanical performances. Lighter alternatives to heavy copper electrical and data wiring are needed in automobiles and aircrafts to enhance fuel efficiencies. In electronics, better interconnects and thermal management components than copper with higher current- and heat-stabilities are required to enable device miniaturization with increased functionality. Our literature survey encouragingly indicates that Cu/CNT performances (electrical, thermal and mechanical) reported so far rival that of Cu, proving the material's viability as a Cu alternative. We identify two grand challenges to be solved for Cu/CNT to replace copper in real-life applications. The first grand challenge is to fabricate Cu/CNT with overall performances exceeding that of copper. To address this challenge, we propose research directions to fabricate Cu/CNT closer to ideal composites theoretically predicted to surpass Cu performances (i.e. <i>those containing uniformly distributed Cu and individually aligned CNTs with beneficial CNT-Cu interactions</i>). The second grand challenge is to industrialize and transfer Cu/CNT from lab bench to real-life use. Toward this, we identify and propose strategies to address market-dependent issues for niche/mainstream applications. The current best Cu/CNT performances already qualify for application in niche electronic device markets as high-end interconnects. However, mainstream Cu/CNT application as copper replacements in conventional electronics and in electrical/data wires are long-term goals, needing inexpensive mass-production by methods aligned with existing industrial practices. Mainstream electronics require cheap CNT template-making and electrodeposition procedures, while data/electrical cables require manufacture protocols based on co-electrodeposition or melt-processing. We note (with examples) that initiatives devoted to Cu/CNT manufacturing for both types of mainstream applications are underway. With sustained research on Cu/CNT and accelerating its real-life application, we expect the successful evolution of highly functional, efficient, and sustainable next-generation electrical and electronics systems.
Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins (2002)

In mammalian cells, repair of the most abundant endogenous premutagenic lesion in DNA, 7,8-dihydro-8-oxoguanine (8-oxoG), is initiated by the bifunctional DNA glycosylase OGG1. By using purified human proteins, we have reconstituted repair of 8-oxoG lesions in DNA in vitro on a plasmid DNA substrate containing a single 8-oxoG residue. It is shown that efficient and complete repair requires only hOGG1, the AP endonuclease HAP1, DNA polymerase (Pol) beta and DNA ligase I. After glycosylase base removal, repair occurred through the AP lyase step of hOGG1 followed by removal of the 3'-terminal sugar phosphate by the 3'-diesterase activity of HAP1. Addition of PCNA had a slight stimulatory effect on repair. Fen1 or high concentrations of Pol beta were required to induce strand displacement DNA synthesis at incised 8-oxoG in the absence of DNA ligase. Fen1 induced Pol beta strand displacement DNA synthesis at HAP1-cleaved AP sites differently from that at gaps introduced by hOGG1/HAP1 at 8-oxoG sites. In the presence of DNA ligase I, the repair reaction at 8-oxoG was confined to 1 nt replacement, even in the presence of high levels of Pol beta and Fen1. Thus, the assembly of all the core proteins for 8-oxoG repair catalyses one major pathway that involves single nucleotide repair patches.
A Natural Rice Mutant From IR22 (1982)

This article 'A Natural Rice Mutant From IR22' appeared in the International Rice Research Newsletter series, created by the International Rice Research Institute (IRRI). The primary objective of this publication was to expedite communication among scientists concerned with the development of improved technology for rice and for rice based cropping systems. This publication will report what scientists are doing to increase the production of rice in as much as this crop feeds the most densely populated and land scarce nations in the world.
Vinylogous urethanes in alkaloid synthesis. Applications to the synthesis of racemic indolizidine 209B and its (5R*,8S *,8aS *)-(±) diastereomer, and to (−)-indolizidine 209B † (2000)

Syntheses of racemic (5R*,8R*,8aS*)-8-methyl-5-pentylindolizidine (indolizidine 209B) (±)-1 and its hitherto unknown (5R*,8S*,8aS*) diastereomer (±)-20 were accomplished in eight steps from pyrrolidine-2-thione and ethyl oct-2-enoate. Key steps included cyclisations exploiting the nucleophilicity of vinylogous urethanes derived from ethyl (2E)-{1-[1-(2-hydroxyethyl)hexyl]pyrrolidin-2-ylidene}acetate 8, and stereoselective reduction of the carbon–carbon double bond of a bicyclic vinylogous urethane 11. An enantioselective modification of the route involving initial conjugate addition of the anion of (R)-(+)-N-benzyl-1-phenylethylamine to tert-butyl (2E)-oct-2-enoate resulted in a formal synthesis of (−)-indolizidine 209B.
Identification of active site serine and histidine residues in <i>Escherichia coli</i> outer membrane protease OmpT (2000)

Escherichia coli outer membrane protease OmpT has been characterised as a serine protease based on its inhibitor profile, but serine protease consensus sequences are absent. By site-directed mutagenesis we substituted all conserved serines and histidines. Substitution of His(101) and His(212) by Ala, Asn or Gln resulted in variant enzymes with 0.01 and 9-20% residual enzymatic activity towards a fluorogenic pentapeptide substrate, respectively. The mutations S140A and S201A did not decrease activity, while variants S40A and S99A yielded 0.5 and 0.2% residual activities, respectively. When measured with a dipeptide substrate the variant S40A demonstrated full activity, whereas variant S99A displayed at least 500-fold reduced activity. We conclude that Ser(99) and His(212) are essential active site residues. We propose that OmpT is a novel serine protease with Ser(99) as the active site nucleophile and His(212) as general base.
Intra- and inter-molecular catalysis in the aminolysis of benzylpenicillin (1980)

The rate law for the aminolysis of benzylpenicillin in water is reported. The Brønsted β-values for the uncatalysed, the amine-catalysed, and hydroxide-ion catalysed reactions are 1.0, 1.09, and 0.96 respectively. This indicates that in the transition states for all three pathways the amine nucleophile contains a unit positive charge which is consistent with the formation of a tetrahedral intermediate. Intramolecular general base catalysis occurs with the reaction of ethylenediamine and, despite the importance of general base catalysis in the aminolysis reaction, the effective concentration of the catalysing base is only ca. 1M, which is attributed to the ‘loose’ transition state involved in intermolecular catalysis. Intramolecular general acid catalysis occurs with the reaction of ethylenediamine monocation. This suggests that nucleophilic attack takes place from the least hindered α-side.
A Survey of Point-of-interest Recommendation in Location-based Social Networks (2016)

Point-of-interest (POI) recommendation that suggests new places for users to visit arises with the popularity of location-based social networks (LBSNs). Due to the importance of POI recommendation in LBSNs, it has attracted much academic and industrial interest. In this paper, we offer a systematic review of this field, summarizing the contributions of individual efforts and exploring their relations. We discuss the new properties and challenges in POI recommendation, compared with traditional recommendation problems, e.g., movie recommendation. Then, we present a comprehensive review in three aspects: influential factors for POI recommendation, methodologies employed for POI recommendation, and different tasks in POI recommendation. Specifically, we propose three taxonomies to classify POI recommendation systems. First, we categorize the systems by the influential factors check-in characteristics, including the geographical information, social relationship, temporal influence, and content indications. Second, we categorize the systems by the methodology, including systems modeled by fused methods and joint methods. Third, we categorize the systems as general POI recommendation and successive POI recommendation by subtle differences in the recommendation task whether to be bias to the recent check-in. For each category, we summarize the contributions and system features, and highlight the representative work. Moreover, we discuss the available data sets and the popular metrics. Finally, we point out the possible future directions in this area and conclude this survey.
Thermal Assisted In Vivo Gene Electrotransfer (2016)

Gene electrotransfer is an effective approach for delivering plasmid DNA to a variety of tissues. Delivery of molecules with electric pulses requires control of the electrical parameters to achieve effective delivery. Since discomfort or tissue damage may occur with high applied voltage, the reduction of the applied voltage while achieving the desired expression may be an important improvement. One possible approach is to combine electrotransfer with exogenously applied heat. Previous work performed in vitro demonstrated that increasing temperature before pulsing can enhance gene expression and made it possible to reduce electric fields while maintaining expression levels. In the study reported here, this combination was evaluated in vivo using a novel electrode device designed with an inserted laser for application of heat. The results obtained in this study demonstrated that increased temperature during electrotransfer increased expression or maintained expression with a reduction in applied voltage. With further optimization this approach may provide the basis for both a novel method and a novel instrument that may greatly enhance translation of gene electrotransfer.
Hierarchical PLS Modeling for Predicting the Binding of a Comprehensive Set of Structurally Diverse Protein−Ligand Complexes (2006)

A new approach is presented for predicting ligand binding to proteins using hierarchical partial-least-squares regression to latent structures (Hi-PLS). Models were based on information from the 2002 release of the PDBbind database containing (after in-house refinement) high-resolution X-ray crystallography and binding affinity (Kd or Ki) data for 612 protein−ligand complexes. The complexes were characterized by four different descriptor blocks: three-dimensional (3D) structural descriptors of the proteins, protein−ligand interactions according to the Validate scoring function, binding site surface areas, and ligand 2D and 3D descriptors. These descriptor blocks were used in Hi-PLS models, generated using both linear and nonlinear terms, to relate the characterizations to pKd/i. The results show that each of the four descriptor blocks contributed to the model, and the predictions of pKd/i of the internal test set gave a root-mean-square error of prediction (RMSEP) of 1.65. The data were further divided according to the structural classification of the proteins, and Hi-PLS models were constructed for the resulting subclasses. The models for the four subclasses differed considerably in terms of both their ability to predict pKd/i (with RMSEPs ranging from 0.8 to 1.56) and the descriptor block that had the strongest influence. The models were validated with an external test set of 174 complexes from the 2003 release of the PDBbind database. The overall results show that the presented Hi-PLS methodology could facilitate the difficult task of predicting binding affinity.
Interactive design of multi-perspective images for visualizing urban landscapes (2005)

Multiperspective images are a useful way to visualize extended, roughly planar scenes such as landscapes or city blocks. However, constructing effective multiperspective images is something of an art. We describe an interactive system for creating multiperspective images composed of serially blended cross-slits images. Beginning with a sideways-looking video of the scene as might be captured from a moving vehicle, we allow the user to interactively specify a set of cross-slits cameras, possibly with gaps between them. In each camera, one of the slits is defined to be the camera path, which is typically horizontal, and the user is left to choose the second slit, which is typically vertical. The system then generates intermediate views between these cameras using a novel interpolation scheme, thereby producing a multiperspective image with no seams. The user can also choose the picture surface in space onto which viewing rays are projected, thereby establishing a parameterization for the image. We show how the choice of this surface can be used to create interesting visual effects. We demonstrate our system by constructing multiperspective images that summarize city blocks, including corners, blocks with deep plazas and other challenging urban situations.
Rapid and quantitative detection of blood<i>Serratia marcescens</i>by a real-time PCR assay: Its clinical application and evaluation in a mouse infection model (2005)

Large-scale nosocomial outbreaks of Serratia marcescens septicaemia in Japan have had a fatality rate of 20-60% within 48 h. As a countermeasure, a real-time PCR assay was constructed for the rapid diagnosis of S. marcescens septicaemia. This assay indeed detected S. marcescens in clinical blood specimens (at ca. 10(2)CFU ml(-1)), at a frequency of 0.5% in suspected cases of septicaemia. In mice, the assay provided estimates of blood S. marcescens levels at various infectious stages: namely, 10(7) to 10(8)CFU ml(-1) at a fatal stage (resulting in 100% death), 10(4)-10(5)CFU ml(-1) at a moderately fatal stage (resulting in 50% or more death), and <10(3)CFU ml(-1) at a mild stage (resulting in 100% survival), consistent with actual CFU measurements. Blood bacterial levels could be an important clinical marker that reflects the severity of septicaemia. The simultaneous detection of S. marcescens and the carbapenem resistance gene was also demonstrated.
Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis (2007)

Epithelial cells (ECs) cover the surfaces of the body such as skin, airways, or the intestinal tract and provide an important link between the outside environment and the body interior. Leukocytes play a critical role in immunity, as they are the predominant cell population involved in inflammation and the only cells providing adaptive immune response to pathogenic microorganisms. ECs and leukocytes form a complex network, which regulates processes such as host defense, immunity, inflammation, tissue repair, and cancer growth. One of the most critical functions of ECs is to keep up a barrier to the outside and to protect the sensitive immune system from continuous contact with external microorganisms. An appropriate response to wounding or danger involves not only killing of microbes but also regulation of tissue repair and reconstitution of the barrier system. Dysregulated response to damage represents a pathophysiological mechanism, which leads to autoimmunity, chronic inflammatory diseases, and cancer development. The networks described here are involved in virtually all diseases that take place at body surfaces. In this article, we develop a concept of epithelial barrier as a critical regulator of leukocyte function and discuss how host defense processes modulate epithelial homeostasis.
An application of Boolean algebra to the design of electronic switching circuits (1953)

IN THE 15 years since Shannon1 introduced the Boolean algebra as an aid towards the analysis and synthesis of switching circuits, this algebra has proved to be a worthwhile addition to the procedures available to the switching circuit designer. Although, in its present form, it cannot be employed to solve many of the problems by which the designer is confronted, the switching algebra provides an exceedingly effective technique in those cases where its use is indicated.