gebhart/patrepeval huggingface dataset:
Identification of Unsuspected PNH-Type Cells in Flow Cytometric Immunophenotypic Analysis of Peripheral Blood and Bone Marrow (2004)

In this report, the flow cytometric expression patterns for CD14 on monocytic cells and CD16 on granulocytic cells in peripheral blood or bone marrow specimens are illustrated for 15 patients proven to have a paroxysmal nocturnal hemoglobinuria (PNH) phenotype by flow cytometric analysis for CD55 and CD59. The varied clinical manifestations of PNH and its rarity may make it difficult to recognize clinically. As a result, blood or bone marrow samples may be submitted for flow cytometric analysis to exclude bone marrow neoplasia or dysplasia in patients with cytopenias rather than to exclude PNH. This was true in 5 of 15 study cases. Unlike CD55 and CD59, CD14 and/or CD16 are assessed routinely in the flow cytometric analysis of blood and bone marrow samples. Recognition of abnormal patterns of CD14 and CD16 expression might permit the identification of clinically unsuspected PNH by routine flow cytometric analysis.
Reflectarray antennas (2018)

The principal concepts of reflectarray antennas have been reviewed in this chapter. Reflectarrays have shown several advantages with respect to reflector and phased-array counterparts. Reflectarrays have demonstrated their capability to produce shaped beams, independent beamforming in each polarization, multi-frequency operation, among others. The limited bandwidth has been significantly overcame by different techniques, including the development of multi-resonant broadband cells and compensation of the spatial phase delay. Different contributions to the state of the art in the topic of reflectarrays for fixed and reconfigurable beams have been presented, including a large variety of the reflectarray cells proposed to improve the antenna performance using different technologies. Some selected recent and ongoing developments have been summarized. Examples such as contour-beam and multibeam reflectarrays, steerable-beam reflectarrays, dual-reflector antennas, reflectarrays in solar panels and deployable and inflatable reflectarrays have been presented. Finally, some challenging technologies and materials, such as 3-D printing, liquid crystals or graphene, can be very promising for future applications in terahertz. The results presented here show a great potential of reflectarrays for passive and reconfigurable antennas in a large range of frequencies from microwaves to terahertz and even optical frequencies.
Synthesis of GD<sub>3</sub> as a 4-Methyl-3-pentenyl Glycoside and Subsequent Conjugation to HSA (1994)

Abstract The total synthesis of the tetrasaccharide sequence of the ganglioside GD3 (α-D-Neup5Ac-(2→8)-α-D-Neup5Ac-(2→3)-β-D-Galp-(1→4)-β-D-Glcp-) as the 4-methyl-3-pentenyl glycoside (13) has been accomplished in a relatively straightforward manner. This derivative displays reasonable 1H NMR characteristics in D2O and has subsequently been coupled to a carrier protein by employing the ozonolysis-reductive amination procedure.
Erratum: Covariant light-front approach for<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>B</mml:mi><mml:mo>→</mml:mo><mml:msup><mml:mi>K</mml:mi><mml:mo>*</mml:mo></mml:msup><mml:mi>γ</mml:mi></mml:math>,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mi>K</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mi>γ</mml:mi></mml:math>,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mi>K</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:mi>γ</mml:mi></mml:math>decays [Phys. Rev. D<b>69</b>, 094007 (2004)] (2010)

The operator si q 1 5 b in Eq. ( Eq. (2.10) should read (2.22)] and, hence, the explicit expressions are also modified.
EVALUATION OF VACCINATION PROGRAMMES AGAINST GUMBORO DISEASE WITH PERSISTANCE OF MATERNALLY DERIVED ANTIBODY IN BROILER CHICKENS (2012)

The study was carried out to evaluate the vaccination programmes with Nobilis® Gumboro D78 (Intervet, Netherland) against Gumboro disease with persistance of maternally derived antibody in broiler chickens during two month period from August to September 2003 in Sherpur district of Bangladesh. A total of seven farms were selected, of which owners of five farms practiced their own vaccination programme i.e., primary vaccination at 5 (three farms), 7 and 8 days old with no booster against infections bursal disease (IBD) whereas imposed vaccination schedule (primary vaccination at 14 days old with a booster at 28 days old) was implemented in the remaining two farms. The vaccination programmes were evaluated by determining the antibody titres before and after vaccination and by morbidity and mortality of the vaccinated chickens against Gumboro disease. The present investigation demonstrated that mortality of chickens occurred in farms in which the birds were vaccinated between 5 to 7 days of age. The present result revealed that 7 days after primary vaccination the titer level decreased significantly (p < 0.05) in all the farms in which the farmers followed their own vaccination schedule. The present result also demonstrated that the mean titer before primary vaccination was 1276.8 ± 43.84 but seven days after vaccination it increased (1434.2 ± 29.97) insignificantly (p > 0.05) and this increasing rend continued up to 14 days after vaccination that is upto the age of 28 days (1549.6 ± 33.38) and seven days after booster dose that is at the age of day 35 the mean titer increased (2886.60 ± 80.67) significantly (p < 0.05) in the remaining two farms where the imposed vaccination programme was implemented. The present results obviously demonstrated that maternal antibody level decreasing about half within five days and decreased to negative level (364.00 ± 9.25) by the day 20. From the present study it may be concluded that broiler birds may primarily be vaccinated at the age of around day 14 with a booster at 28 days old.
DUPLICATIONS IN <i>CAENORHABDITIS ELEGANS</i> (1979)

Thirteen chromosomal duplications, all unlinked to their linkage of origin, have been identified following X-irradiation. Ten are X-chromosome duplications, of which six are half-translocations on three autosomomal linkage groups and four are free fragments. Five of the half-translocations are homozygous fertile and two are recognizable cytologically as chromosome satellites, both of which show some mitotic instability. The free-X duplications show varying tendencies for loss. Three appear not to overlap in extent previously identified free-X duplications. The fourth carries genes from linkage group V, as well as X. Three duplications of a portion of linkage group II were identified and found to be free and quite stable in hyperploids. Some of the free duplications tend to disjoin from the X chromosome in males. New X-chromosome map data are presented.
Alpha-Amylases as Calcium-Metalloenzymes. I. Preparation of Calcium-free Apoamylases by Chelation and Electrodialysis<sup>*</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlpha-Amylases as Calcium-Metalloenzymes. I. Preparation of Calcium-free Apoamylases by Chelation and Electrodialysis*Eric A. Stein, Julia Hsiu, and Edmond H. FischerCite this: Biochemistry 1964, 3, 1, 56–61Publication Date (Print):January 1, 1964Publication History Published online1 May 2002Published inissue 1 January 1964https://pubs.acs.org/doi/10.1021/bi00889a010https://doi.org/10.1021/bi00889a010research-articleACS PublicationsRequest reuse permissionsArticle Views185Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Yield and reliability of MNOS EEPROM products (1989)

MNOS electrically erasable and programmable read-only memory (EEPROM) products have been manufactured using 2- mu m CMOS fabrication technology, in which MNOS memory devices are composed of a 1.6-nm tunnel SiO/sub 2/ layer and a 28-nm Si/sub 3/N/sub 4/ layer. The Hitachi MNOS EEPROM family consists of a 64-kb EEPROM with static random access memory (SRAM) timing and three EEPROM on-chip microcomputers. Electrical and quality tests establish two basic reliability features: ten-year data retention and 10/sup 5/ erase/write cycle endurance. The MNOS EEPROM family yield has reached the same high level as that of SRAM products fabricated with the same 2- mu m CMOS technology. In addition, high-density low-cost MNOS EEPROM products are possible because of the high scalability and high yield attributable to their simple cell structure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Characterization of 68Ga-DOTA-D-Phe1-Tyr3-octreotide kinetics in patients with meningiomas. (2005)

The high uptake of (68)Ga-DOTA-TOC in meningiomas can be explained by the high values for vB and by the remarkably low values for k2 and k4, leading to significantly greater k1/k2 and k3/k4 ratios and RB in meningiomas than in reference tissue. Thus, pharmacokinetic modeling offers a more detailed analysis of biologic properties of meningiomas. In further studies, these data might serve as a basis for monitoring the somatostatin receptors of meningiomas after radiotherapy.
Heterogeneous architecture design with emerging 3D and non-volatile memory technologies (2015)

Energy becomes the primary concern in nowadays multi-core architecture designs. Moore's law predicts that the exponentially increasing number of cores can be packed into a single chip every two years, however, the increasing power density is the obstacle to continuous performance gains. Recent studies show that heterogeneous multi-core is a competitive promising solution to optimize performance per watt. In this paper, different types of heterogeneous architecture are discussed. For each type, current challenges and latest solutions are briefly introduced. Preliminary analyses are performed to illustrate the scalability of the heterogeneous system and the potential benefits towards future application requirements. Moreover, we demonstrate the advantages of leveraging three-dimensional (3D) integration on heterogeneous architectures. With 3D die stacking, disparate technologies can be integrated on the same chip, such as the CMOS logic and emerging non-volatile memory, enabling a new paradigm of architecture design. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup>
Synthesis of Ultralong Copper Nanowires for High-Performance Transparent Electrodes (2012)

Cu nanowires hold great promise for the fabrication of low-cost transparent electrodes. However, their current synthesis is mainly performed in aqueous media with poor nanowire dispersibility. We report herein the novel synthesis of ultralong single-crystalline Cu nanowires with excellent dispersibility, providing an excellent candidate material for high-performance transparent electrode fabrication.
Purification and Some Physicochemical Properties of Slow‐Reacting Substance of Anaphylaxis (SRS‐A) from Sensitized Guinea Pig Lung (1979)

Abstract The slow‐reacting substance of anaphylaxis (SRS‐A) generated by antigen challenge of sensitized guinea pig lung fragments was partially purified and the physicochemical properties of this activity were studied. The SRS‐A recovered from antigen challenged lung preparations of 600 animals was used for the purification procedure. Treatment with organic solvents, extraction with 80% ethanol, Sephadex LH‐20 chromatography with 80% ethanol, and DEAE‐Sephadex A‐25 chromatography in 60% methanol eluted with 0.0 to 0.1 M NaCl in 60% methanol was the purification sequence finally adopted. Overall recovery of SRS‐A bioactivity was 60% with a specific activity of 2.52 units/ng of dry weight. This represented a 1.67 million‐fold purification over the starting material. The DEAE‐Sephadex A‐25 step alone provided a 7600‐fold purification. This highly purified SRS‐A had an apparent molecular weight of 380 to 400 daltons. The bioactivity was acid labile and alkaline stable and was blocked by low concentrations of the SRS‐A antagonist FPL 55712. The SRS‐A was thermostable in aqueous media and displayed enhanced bioactivity after heating at 60 C for 60 min. These results indicate that we have developed a highly efficient new approach to the isolation of guinea pig SRS‐A, which also may be useful in the study of SRS‐A from other tissues or species. The physicochemical properties of guinea pig SRS‐A appear to be very similar to those of SRS‐A from other species.
Spiderweb Masks for High‐Contrast Imaging (2003)

Motivated by the desire to image exosolar planets, recent work by us and others has shown that high-contrast imaging can be achieved using specially shaped pupil masks. To date, the masks we have designed have been symmetric with respect to a cartesian coordinate system but were not rotationally invariant, thus requiring that one take multiple images at different angles of rotation about the central point in order to obtain high-contrast in all directions. In this paper, we present a new class of masks that have rotational symmetry and provide high-contrast in all directions with just one image. These masks provide the required 10^{-10} level of contrast to within 4 lambda/D, and in some cases 3 lambda/D, of the central point, which is deemed necessary for exosolar planet finding/imaging. They are also well-suited for use on ground-based telescopes, and perhaps NGST too, since they can accommodate central obstructions and associated support spiders.
Use of a Geographic Information System To Identify and Characterize Areas with High Proportions of Distant Stage Breast Cancer (2002)

A spatial scan statistic was used to search for geographic areas with significantly elevated proportions of women diagnosed with distant stage breast cancer in New Jersey in 1995-1997. The identified areas then were mapped and characterized using data from the 1990 U.S. Census and locations of mammography facilities. These areas' population characteristics included relatively high proportions of black or Hispanic women and linguistically isolated households. Targeted education and screening programs using this information may increase the diagnosis of breast cancer in the early stages, thereby reducing breast cancer mortality.
The low-loss plasmonic mode for light confinement in silicon-based thin-film solar cells (2010)

In amorphous silicon (and its alloys) solar cells, because of the low carrier mobility and light induced degradation, a device of a thinner intrinsic layer has the advantage of higher carrier harvest in generating photocurrent. It is therefore critical to keep efficient absorption within limit thickness to both retain higher short-circuit current and filling factor of devices. Furthermore, the future trend of silicon-based thin film solar cells, double and triple junction solar cells, largely depends on micro-crystalline silicon layers. In order to enlarge market share, lowering the production cost though reducing the thickness of micro-crystalline silicon layers is the current interest in industry and academic research. Therefore, to keep a high level of photocurrent, thinner absorbing layers require efficient light management scheme. One of the candidates, surface plasmon assisted light confinement, has been demonstrated feasible with slight improvement. However, huge metallic loss in metal structures hinders further improvement in SPP-assisted thin film solar cells. Owing to the existence of optical loss in metallic structures, we propose a numerical method to analysis a multilayer system incorporating low-loss plasmonic modes with better light confinement. Meanwhile, we estimate the light-trapping effect in the textured transparent conducting oxide (TCO) which plays a coupling medium between sunlight and confined modes in solar cells.
CLIER – combination of LINC and EER method (2006)

For efficient amplification of broadband multicarrier signals a circuit configuration combining LINC and EER is proposed. The amplified lowpass part of the signal envelope is taken as the supply voltage for two nonlinear RF amplifiers. Their inputs are fed with signals at a centre frequency, the phases of which contain in addition to the signal phase a further phase difference. The cosine of this difference is proportional to the signal envelope divided by the above-mentioned lowpass part of the envelope. The sum of the amplifier outputs returns the desired signal. The method is described and the feasibility using a typical OFDM modulation scheme is demonstrated.
Cross relaxation without TOCSY: transverse rotating-frame Overhauser effect spectroscopy (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCross relaxation without TOCSY: transverse rotating-frame Overhauser effect spectroscopyTsang Lin Hwang and A. J. ShakaCite this: J. Am. Chem. Soc. 1992, 114, 8, 3157–3159Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/ja00034a083https://doi.org/10.1021/ja00034a083research-articleACS PublicationsRequest reuse permissionsArticle Views1025Altmetric-Citations267LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
End‐Capping Effect of a Narrow Bandgap Conjugated Polymer on Bulk Heterojunction Solar Cells (2011)

Device performances of BHJ solar cells based on poly[(4,4-didodecyldithieno[3,2-b:2’,3’-d]silole)-2,6-diyl-alt-(2,1,3-benzoxadiazole)-4,7-diyl]and PC71BM improve by capping the chain ends with thiophene fragments. This structural modification yields materials that are more thermally robust and that can be used in devices with thicker films – important considerations for enabling the mass production of plastic solar cells. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Efficient Intramolecular Hydroalkoxylation of Unactivated Alkenols Mediated by Recyclable Lanthanide Triflate Ionic Liquids: Scope and Mechanism (2010)

Lanthanide triflate complexes of the type [Ln(OTf)(3)] (Ln=La, Sm, Nd, Yb, Lu) serve as effective, recyclable catalysts for the rapid intramolecular hydroalkoxylation (HO)/cyclization of primary/secondary and aliphatic/aromatic hydroxyalkenes in imidazolium-based room-temperature ionic liquids (RTILs) to yield the corresponding furan, pyran, spirobicyclic furan, spirobicyclic furan/pyran, benzofuran, and isochroman derivatives. Products are straightforwardly isolated from the catalytic solution, conversions exhibit Markovnikov regioselectivity, and turnover frequencies are as high as 47 h(-1) at 120 degrees C. The ring-size rate dependence of the primary alkenol cyclizations is 5>6, consistent with a sterically controlled transition state. The hydroalkoxylation/cyclization rates of terminal alkenols are slightly more rapid than those of internal alkenols, which suggests modest steric demands in the cyclic transition state. Cyclization rates of aryl-functionalized hydroxyalkenes are more rapid than those of the linear alkenols, whereas five- and five/six-membered spirobicyclic skeletons are also regioselectively closed. In cyclization of primary, sterically encumbered alkenols, turnover-frequency dependence on metal-ionic radius decreases by approximately 80-fold on going from La(3+) (1.160 A) to Lu(3+) (0.977 A), presumably reflecting steric impediments along the reaction coordinate. The overall rate law for alkenol hydroalkoxylation/cyclization is v approximately k[catalyst](1)[alkenol](1). An observed ROH/ROD kinetic isotope effect of 2.48 (9) is suggestive of a catalytic pathway that involves kinetically significant intramolecular proton transfer. The present activation parameters--enthalpy (DeltaH(++))=18.2 (9) kcal mol(-1), entropy (DeltaS(++))=-17.0 (1.4) eu, and energy (E(a))=18.2 (8) kcal mol(-1)--suggest a highly organized transition state. Proton scavenging and coordinative probing results suggest that the lanthanide triflates are not simply precursors of free triflic acid. Based on the kinetic and mechanistic evidence, the proposed catalytic pathway invokes hydroxyl and olefin activation by the electron-deficient Ln(3+) center, and intramolecular H(+) transfer, followed by alkoxide nucleophilic attack with ring closure.
Identifying Parents in Need: An Approach to Adoptive Parenting (1981)

MCN, The American Journal of Maternal/Child Nursing: March 1981 - Volume 6 - Issue 2 - p 118-123
Paratope- and framework-related cross-reactive idiotopes on anti-acetylcholine receptor antibodies (1991)

Cross-reactive idiotopes are a possible target for therapeutical interventions in autoimmune diseases. To investigate their role in the pathogenesis of experimental autoimmune myasthenia gravis (EAMG) we analyzed the Id of rat anti-AChR mAb 6, 35, 61, 65 and a control myeloma protein IR27. Anti-Id 6, 35, 61, 65 bound in a direct binding assay with various affinity to all rat anti-AChR mAb that were tested. Anti-Id IR27 recognized none of the anti-AChR mAb. The specificity of these crossreactions was confirmed by inhibition studies with anti-AChR mAb and two control rat myeloma proteins (IR27 and IR241). In addition, the Id expression on mAb D6, a mouse anti-human AChR mAb was recognized by anti-Id 6, 35, and 65. Anti-Id, except anti-Id IR27, bound to affinity purified IgG from the sera of rats with EAMG, but not to preimmune Lewis IgG. These results suggest extensive sharing of idiotopes among anti-AChR mAb, which are also present in EAMG serum. Anti-AChR mAb against the main immunogenic region (6, 35, 65) from different rat strains, shared at least one paratope-related cross-reactive idiotopes. In the view of the fact that anti-main immunogenic region antibodies might form a predominant fraction of the polyclonal response against AChR, it is conceivable that an anti-Id recognizing these antibodies could have therapeutical applications as for example a selective immune absorbent or in immunotoxin therapy.