gebhart/patrepeval huggingface dataset:
Automated Camera Placement using Hybrid Particle Swarm Optimization (2014)

Context. Automatic placement of surveillance cameras' 3D models in an arbitrary floor plan containing obstacles is a challenging task. The problem becomes more complex when different types of region of interest (RoI) and minimum resolution are considered. An automatic camera placement decision support system (ACP-DSS) integrated into a 3D CAD environment could assist the surveillance system designers with the process of finding good camera settings considering multiple constraints. Objectives. In this study we designed and implemented two subsystems: a camera toolset in SketchUp (CTSS) and a decision support system using an enhanced Particle Swarm Optimization (PSO) algorithm (HPSO-DSS). The objective for the proposed algorithm was to have a good computational performance in order to quickly generate a solution for the automatic camera placement (ACP) problem. The new algorithm benefited from different aspects of other heuristics such as hill-climbing and greedy algorithms as well as a number of new enhancements. Methods. Both CTSS and ACP-DSS were designed and constructed using the information technology (IT) research framework. A state-of-the-art evolutionary optimization method, Hybrid PSO (HPSO), implemented to solve the ACP problem, was the core of our decision support system. Results. The CTSS is evaluated by some of its potential users after employing it and later answering a conducted survey. The evaluation of CTSS confirmed an outstanding satisfactory level of the respondents. Various aspects of the HPSO algorithm were compared to two other algorithms (PSO and Genetic Algorithm), all implemented to solve our ACP problem. Conclusions. The HPSO algorithm provided an efficient mechanism to solve the ACP problem in a timely manner. The integration of ACP-DSS into CTSS might aid the surveillance designers to adequately and more easily plan and validate the design of their security systems. The quality of CTSS as well as the solutions offered by ACP-DSS were confirmed by a number of field experts.
Quaternary ammonium biocides as antimicrobial agents protecting historical wood and brick. (2015)

Quaternary ammonium compounds (QACs) are widely used in disinfection of water, surfaces and instruments as well as in textile, leather and food industries because of their relatively low toxicity, broad antimicrobial spectrum, non-volatility and chemical stability. Due to these advantages, QACs are also used in restoration and can be applied on historical material. The aim of this study was to determine the usefulness of biocides based on quaternary ammonium salts and containing various excipients in the protection of historical materials against microbial growth. The study determined the antimicrobial activity of three biocides against bacteria: Pseudomonas fluorescens, Staphylococcus equorum, Bacillus cereus, Bacillus muralis, Sporosarcina aquimarina and Rhodococcus fascians, and moulds: Chaetomium globosum, Penicillium citreonigrum, Cladosporium cladosporioides I, Acremonium strictum, Aspergillus fumigatus and Cladosporium cladosporioides II, all isolated from historical wood and brick. Staphylococcus equorum, Bacillus cereus, Sporosarcina aquimarina and Rhodococcus fascians bacteria, and Cladosporium cladosporioides I and Acremonium strictum moulds showed high sensitivity to quaternary ammonium biocides. Historical wood can be effectively disinfected by three applications of biocide A (30% v/v) containing dodecyl dimethyl ammonium chloride (DDAC), citric acid, propiconazole and propanol. Disinfection of historical brick can be carried out by three applications of 6% v/v solutions of biocide B (based on DDAC and ethylenediaminetetraacetic acid - EDTA) or biocide C (containing a non-ionic surfactant, DDAC and EDTA). Effective protection of historical building materials against microbial growth for a period of seven days can be achieved by the application of biocide A (30% v/v) on the wood surface and biocide B (6% v/v) on the brick surface.
Retinoic Acid Metabolism and Mechanism of Action: A Review (2003)

Retinoids are vitamin A (retinol) derivatives essential for normal embryo development and epithelial differentiation. These compounds are also involved in chemoprevention and differentiation therapy of some cancers, with particularly impressive results in the management of acute promyelocytic leukemia (APL). Although highly effective in APL therapy, resistance to retinoic acid (RA) develops rapidly. The causes of this resistance are not completely understood and the following factors have been involved: increased metabolism, increased expression of RA binding proteins, P-glycoprotein expression, and mutations in the ligand binding domain of RARalpha. RA exerts its molecular actions mainly through RAR and RXR nuclear receptors. In addition to the nuclear receptor based mechanism of RA action, covalent binding of RA to cell macromolecules has been reported. RA derives from retinol by oxidation through retinol and retinal dehydrogenases, and several cytochrome p450s (CYPs). RA is thereafter oxidized to several metabolites by a panel of CYPs that differs for the different RA isomers. Phase II metabolism, mainly glucuronidation, is also observed. The role RA metabolism plays in the expression of its biological actions is not completely understood: in several systems, metabolism decreases RA activity, whereas in other systems metabolism appears involved in its action. In addition, several RA metabolites have shown activity and cannot be classified as only catabolites. Therapy of cancer with retinoids is still in its infancy, but the use of new analogues with improved pharmacological properties, along with combination with other drugs, could undoubtedly improve the management of several cancers in the future.
Correlation between the thermal stability and activation energy of crystallization in metallic glasses (1976)

The origin of a large spread in the activation energy of crystallization, ΔE, in metallic glasses is explained based on a structural relaxation model. The calculated ΔE from the available thermal and viscosity data is in fair agreement with the experimental results. It is the structural relaxation which leads to high ΔE (⩾100 kcal/mole) for stable glasses. It is also suggested that the structural relaxation is the rate-controlling factor during the crystallization of the unstable glasses. Thus ΔE for unstable glasses is low (ΔE⩽20 kcal/mole), and is expected to be lower for amorphous metals prepared by low-temperature deposition than for the corresponding melt-quenched metallic glasses.
The v-Crk Oncogene Enhances Cell Survival and Induces Activation of Protein Kinase B/Akt (2001)

The v-Crk oncogene encodes an adaptor protein containing an SH2 domain and an SH3 domain. v-Crk-transformed fibroblast cells display enhanced tyrosine phosphorylation levels, and the v-Crk protein localizes in focal adhesions, suggesting that transformation may be due to enhanced focal complex signaling. Here we investigated the mechanism of transformation and found that v-Crk-transformed NIH 3T3 cells display growth rates and serum requirements similar to control cells. However, v-Crk enhanced survival in conditions of serum starvation. Both an intact SH2 and SH3 domain are required; moreover, SH2 mutants displayed dominant interfering properties, enhancing cell death. Using other cell death-inducing stimuli, it appeared that v-Crk in general inhibits apoptosis and enhances cell survival. In search of the signaling pathways involved, we found that v-Crk-transformed cells show constitutively higher levels of phospho-protein kinase B (PKB)/Akt and PKB/Akt activity, especially in conditions of serum starvation. These data strongly suggest involvement of the phosphatidylinositol 3-kinase/PKB survival pathway in the v-Crk-induced protection against apoptosis. In accordance, inhibition of this pathway by wortmannin or LY924002 reduced protection against starvation-induced apoptosis. In addition to the phosphatidylinositol 3-kinase/PKB pathway, a MEK-dependent pathway and an unknown additional pathway are also implicated in resistance against apoptosis. Activation of survival pathways may be the most important function of v-Crk in its oncogenic properties.
Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements (2014)

Vector-borne protozoan diseases represent a serious public health challenge, especially in the tropics where poverty together with vector-favorable climates are the aggravating factors. Each of the various strategies currently employed to face these scourges is seriously inadequate. Despite enormous efforts, vaccines-which represent the ideal weapon against these parasitic diseases-are yet to be sufficiently developed and implemented. Chemotherapy and vector control are therefore the sole effective attempts to minimize the disease burden. Nowadays, both strategies are also highly challenged by the phenomenon of drug and insecticide resistance, which affects virtually all interventions currently used. The recently growing support from international organizations and governments of some endemic countries is warmly welcome, and should be optimally exploited in the various approaches to drug and insecticide research and development to overcome the burden of these prevalent diseases, especially malaria, leishmaniasis, Human African Trypanosomiasis (HAT), and Chagas disease.
Hyperbolic Heat Conduction Equation for Materials With a Nonhomogeneous Inner Structure (1990)

The physical meaning of the constant τ in Cattaneo and Vernotte’s equation for materials with a nonhomogeneous inner structure has been considered. An experimental determination of the constant τ has been proposed and some values for selected products have been given. The range of differences in the description of heat transfer by parabolic and hyperbolic heat conduction equations has been discussed. Penetration time, heat flux, and temperature profiles have been taken into account using data from the literature and our experimental and calculated results.
Rac GTPases Are Required for MLL-AF9-Induced Mixed Lineage Leukemia. (2008)

Abstract The t(9;11) translocation fusion gene MLL-AF9 (MA9) is commonly found in acute myeloid and lymphoid leukemia and is associated with intermediate to poor outcome. The specific signaling pathways downstream of MA9 are still poorly understood. It has recently been reported that MA9 leukemia cells express higher levels of the small GTPase protein Rac and CDC42 when compared to in vitro MA9 immortal cells in a murine model. To determine the importance of Rac GTPase signaling in MA9-induced transformation, we used an MA9 leukemia model we recently established involving MA9 fusion gene expression in human CD34+ cells. Treatment with the Rac specific inhibitor NSC23766, or transient knockdown of Rac expression by RNAi, induced rapid apoptosis in MA9 cells but not in normal cord blood or t(8;21) translocation fusion gene AML-ETO expressing cells. These data demonstrate that the Rac signaling pathway plays a critical role in the growth and survival of MA9 leukemia cells. To extend this work to an in vivo genetic model, we used mice deficient in Rac2 (Rac2-KO) or with floxed alleles of Rac1 in mice transgenic for Mx-Cre. Leukemia development was compared in mice transplanted with MA9-transduced wild type, Rac1 or Rac2 deficient low density bone marrow cells. Poly I:C injections were performed 2 weeks after transplantation to delete Rac1. Rac deletion was confirmed by PCR and western blot analysis. Mice that received either WT or Rac1−/ − MA9 expressing cells uniformly developed AML and died at 3 to 5 months. Mice transplanted with Rac2-KO cells expressing MA9 showed a decreased incidence and increased latency (6 to 10 months) of AML development despite the persistent engraftment of MA9-expressing cells. All three groups of mice maintained MA9 EGFP+ cells in peripheral blood over the entire experiment, and eventually gave rise to similar end stage AML with a Gr-1+/Mac-1+/Kit+/B220-/CD3- phenotype and myelomonocytic blast morphology. Combined with our observation in human CD34+ cord blood cells transduced with MA9, these in vitro and in vivo data indicate that MA9-mediated transformation and survival requires Rac and their downstream effectors. Rac2 signaling appears to be particularly important in the murine MA9 AML model. Therapeutic targeting of Rac could be a unique and important approach to treating MLL leukemia.
SURVIVAL OF SERRATIA MARCESCENS AFTER FREEZE-DRYING OR AEROSOLIZATION AT UNFAVORABLE HUMIDITY I. (1962)

Zimmerman, Leonard (U.S. Army Biological Laboratories, Fort Detrick, Frederick, Md.). Survival of Serratia marcescens after freeze-drying or aerosolization at unfavorable humidity. I. Effects of sugars. J. Bacteriol. 84:1297-1302. 1962.-Suspensions of Serratia marcescens were subjected to freeze-drying or to aerosolization at unfavorable humidity levels. The survival of the cells during one or the other of these treatments was markedly improved in the presence of common sugars, but no one sugar stabilized the cells against both stresses. The protective effects of the sugars were correlated with their penetrability into cells; minimally penetrable sugars stabilized cells against aerosolization, and freely penetrable sugars stabilized cells during freeze-drying. These results were attributed to the modifications of intracellular water content induced by the presence of the sugars in the cell suspensions.
What the laser can't do for industry (1977)

Report on Laser processing of engineering materials, Institute of Physics, 30 June 1977 at the Skyline Hotel, Heathrow Airport.
Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells (2000)

The epidermal growth factor (EGF) family of receptors (EGFR) is overproduced in estrogen receptor (ER) negative (-) breast cancer cells. An inverse correlation of the level of EGFR and ER is observed between ER- and ER positive (+) breast cancer cells. A comparative study with EGFR-overproducing ER- and low-level producing ER+ breast cancer cells suggests that EGF is a major growth-stimulating factor for ER- cells. An outline of the pathway for the EGF-induced enhanced proliferation of ER- human breast cancer cells is proposed. The transmission of mitogenic signal induced by EGF-EGFR interaction is mediated via activation of nuclear factor kappaB (NF-kappaB). The basal level of active NF-kappaB in ER- cells is elevated by EGF and inhibited by anti-EGFR antibody (EGFR-Ab), thus qualifying EGF as a NF-kappaB activation factor. NF-kappaB transactivates the cell-cycle regulatory protein, cyclin D1, which causes increased phosphorylation of retinoblastoma protein, more strongly in ER- cells. An inhibitor of phosphatidylinositol 3 kinase, Ly294-002, blocked this event, suggesting a role of the former in the activation of NF-kappaB by EGF. Go6976, a well-characterized NF-kappaB inhibitor, blocked EGF-induced NF-kappaB activation and up-regulation of cell-cycle regulatory proteins. This low molecular weight compound also caused apoptotic death, predominantly more in ER- cells. Thus Go6976 and similar NF-kappaB inhibitors are potentially novel low molecular weight therapeutic agents for treatment of ER- breast cancer patients.
The Bi-Gaussian S-Transform (2003)

The S-transform kernel is derived from the kernel of the Fourier transform through the introduction of a scalable, translating window. The width of the window is a function of inverse frequency. In effect the S-transform is a method of spectral localization, with some similarities to wavelet transforms but using the concept of frequency rather than the concept of scale. An important property of the S-transform is that it collapses into the Fourier transform when integrated over the time axis; this property requires the window to satisfy a normalizing condition. The window which has been used in the majority of previous S-transform research is the symmetric Gaussian window introduced by Stockwell, Mansinha, and Lowe [IEEE Trans. Signal Process., 44 (1996), pp. 998--1001]. One problem with the use of a Gaussian, however, is degradation of time resolution in the time-frequency spectrum due to the long front taper. In this paper, a bi-Gaussian window is introduced, constructed through the welding of two half Gaussian windows. The asymmetry of the bi-Gaussian introduces asymmetry in the resultant time-frequency spectrum, with time resolution better in the "front" direction, as compared with the "back" direction. The bi-Gaussian S-transform is better at resolving the sharp onset of events in a time series.
BIOLOGIC PROPERTIES OF DENGUE VIRUSES FOLLOWING SERIAL PASSAGE IN PRIMARY DOG KIDNEY CELLS: STUDIES AT THE UNIVERSITY OF HAWAII (2003)

Serial passage at low dilution of seven different wild-type dengue (DEN) viruses into primary dog kidney (PDK) cell cultures placed selective pressure that resulted in the following changes from parental phenotype: smaller plaques in LLC-MK2 cells, absent plaque formation in green monkey kidney cells, lack of a cytopathic effect in LLC-MK2 cells, shut-off of virus replication at high temperatures (temperature sensitivity), reduced virulence for rhesus monkeys manifested by reduced or absent viremia and/or absence of a secondary-type antibody response following homotypic challenge, and progressive increase in the mean day of death following intracerebral inoculation of sucking mice. Two DEN-1 strains showed most of these changes by the 15th PDK passage. Only one of two DEN-2 strains studied was carried to the 50th PDK passage at the University of Hawaii. For the latter strain, both the temperature of viral replicative shutoff and mouse neurovirulence were reduced. Three DEN-4 strains showed similar late-passage biologic marker changes. The observations made, although not exhaustive, provide laboratory correlates for virus strains that have shown reduced virulence but retained immunogenicity in humans. Candidate human vaccines have been prepared from five of the studied strains: DEN-1 (16007) at PDK 13, DEN-2 (16681 and S-16803) at PDK 50 or above, and DEN-4 (1036 and 341750) at PDK 48 and 20, respectively.
Machine Learning for Cognitive Network Management (2018)

Over the last decade, a significant amount of effort has been invested on architecting agile and adaptive management solutions in support of autonomic, self-managing networks. Autonomic networking calls for automated decisions for management actions. This can be realized through a set of pre-defined network management policies engineered from human expert knowledge. However, engineering sufficiently accurate knowledge considering the high complexity of today's networking environment is a difficult task. This has been a particularly limiting factor in the practical deployment of autonomic systems. ML is a powerful technique for extracting knowledge from data. However, there has been little evidence of its application in realizing practical management solutions for autonomic networks. Recent advances in network softwarization and programmability through SDN and NFV, the proliferation of new sources of data, and the availability of lowcost and seemingly infinite storage and compute resource from the cloud are paving the way for the adoption of ML to realize cognitive network management in support of autonomic networking. This article is intended to stimulate thought and foster discussion on how to defeat the bottlenecks that are limiting the wide deployment of autonomic systems, and the role that ML can play in this regard.
Idiopathic hyposmia as a preclinical sign of Parkinson's disease (2004)

Olfactory dysfunction is an early and common symptom in Parkinson's disease (PD). In an effort to determine whether otherwise unexplained (idiopathic) olfactory dysfunction is associated with an increased risk of developing PD, we designed a prospective study in a cohort of 361 asymptomatic relatives (parents, siblings, or children) of PD patients. A combination of olfactory detection, identification, and discrimination tasks was used to select groups of hyposmic (n = 40) and normosmic (n = 38) individuals for a 2-year clinical follow-up evaluation and sequential single-photon emission computed tomography (SPECT), using [123I]beta-CIT as a dopamine transporter ligand, to assess nigrostriatal dopaminergic function at baseline and 2 years from baseline. A validated questionnaire, sensitive to the presence of parkinsonism, was used in the follow-up of the remaining 283 relatives. Two years from baseline, 10% of the individuals with idiopathic hyposmia, who also had strongly reduced [123I]beta-CIT binding at baseline, had developed clinical PD as opposed to none of the other relatives in the cohort. In the remaining nonparkinsonian hyposmic relatives, the average rate of decline in dopamine transporter binding was significantly higher than in the normosmic relatives. These results indicate that idiopathic olfactory dysfunction is associated with an increased risk of developing PD of at least 10%.
Windows CE 3.0 : application programming (2000)

Windows CE 3.0 Application Programming presents programming for Pocket PC, handheld PC, and embedded devices.Topics include:Enterprise computing including COM, DCOM, database access using ADOCE, and Microsoft Message QueueCommunications, including Internet Web access with HTTP, TCP/IP, sockets, serial communications, and desktop synchronization with ActiveSync 3.0Build and run applications in Visual C++ using Microsoft Foundation ClassesCD-ROM with eMbedded Visual C++ 3.0 and Pocket PC SDKBeyond the user interface to hard-core programmingFull-scale networking and enterprise computingGlobal communications from Pocket PCsAll the new features of Windows CE 3.0Advanced techniques for serious Windows CE programmersWindows CE 3.0 Application Programming helps you get beyond user interface programming and discover the behind-the-scenes operating system facilities that will let you make the most of the new features in Windows CE 3.0. This hot technology lets you control Pocket PCs, handheld PCs, and the embedded devices in hundreds of commercial products. Learn the lean and mean techniques that keep your programs humming on portable devices with limited memory, and the key data storage methods that make them possible. Master the communications protocols that keep Windows CE devices in contact with desktop computers and the Internet.In addition:Build and run applications in Visual C++ 6.0 and eMbedded Visual C++ 3.0Use the Windows CE API and Microsoft Foundation ClassesCommunicate via HTTP, TCP/IP, sockets, remote access, and telephonyAccess standard Windows CE databases and Microsoft SQL Server for Windows CEInterface between desktop systems and Windows CE devicesWindows CE 3.0 Application Programming is for serious developers with real programming experience. Besides familiarity with Windows CE devices and general Windows API programming, a basic knowledge of C and C++ is needed to understand the code samples.The accompanying CD-ROM contains all the code examples from the book, as well as a fully searchable index of all the book's examples, programs, and tutorials. The CD-ROM also contains a complete working copy of eMbedded Visual C++ 3.0 and Pocket PC SDK.