gebhart/patrepeval huggingface dataset:
Neuronal Expression of an FMRFamide-Gated Na<sup>+</sup>Channel and Its Modulation by Acid pH (2001)

The molluscan Phe-Met-Arg-Phe-amide (FMRFamide)-gated sodium channels (FaNaCs) show both structural and functional similarities to the mammalian acid-sensing ion channels (ASICs). Both channel types are related to the epithelial sodium channels and, although the neuropeptide FMRFamide directly gates the FaNaCs, it also modulates the proton-gating properties of ASICs. It is not yet known whether protons can alter the gating properties of the FaNaCs. We chose to examine this possibility at a site of FaNaC expression in the nervous system of the mollusk Lymnaea stagnalis. We cloned a putative L. stagnalis FaNaC (LsFaNaC) that exhibited a high degree of sequence identity to the Helix aspersa FaNaC (HaFaNaC, 60%), and a weaker homology to the ASICs (ASIC3, 22%). In situ hybridization was used to map the LsFaNaC expression pattern in the brain and to identify the right pedal giant1 (RPeD1) neuron as a site where the properties of the endogenous channel could be studied. In RPeD1 neurons isolated in culture, we demonstrated the presence of an FMRFamide-gated sodium current with features expected for a FaNaC: amiloride sensitivity, sodium selectivity, specificity for FMRFamide and Phe-Leu-Arg-Phe-amide (FLRFamide), and no dependency on G-protein coupling. The sodium current also exhibited rapid desensitization in response to repeated FMRFamide applications. Lowering of the pH of the bathing solution reduced the amplitude of the FMRFamide-gated inward current, while also activating an additional sustained weak inward current that was apparently not mediated by the FaNaC. Acidification also prevented the desensitization of the FMRFamide-induced inward current. The acid sensitivity of LsFaNaC is consistent with the hypothesis that FaNaCs share a common ancestry with the ASICs.
Atomic layer deposition of ZnO on ultralow-density nanoporous silica aerogel monoliths (2005)

We report on atomic layer deposition of an ∼2-nm-thick ZnO layer on the inner surface of ultralow-density (∼0.5% of the full density) nanoporous silica aerogel monoliths with an extremely large effective aspect ratio of ∼105 (defined as the ratio of the monolith thickness to the average pore size). The resultant monoliths are formed by amorphous-SiO2 core/wurtzite-ZnO shell nanoparticles which are randomly oriented and interconnected into an open-cell network with an apparent density of ∼3% and a surface area of ∼100m2g−1. Secondary ion mass spectrometry and high-resolution transmission electron microscopy imaging reveal excellent uniformity and crystallinity of ZnO coating. Oxygen K-edge and Zn L3-edge soft x-ray absorption near-edge structure spectroscopy shows broadened O p- as well as Zn s- and d-projected densities of states in the conduction band.
Triplexator: Detecting nucleic acid triple helices in genomic and transcriptomic data (2012)

Double-stranded DNA is able to form triple-helical structures by accommodating a third nucleotide strand in its major groove. This sequence-specific process offers a potent mechanism for targeting genomic loci of interest that is of great value for biotechnological and gene-therapeutic applications. It is likely that nature has leveraged this addressing system for gene regulation, because computational studies have uncovered an abundance of putative triplex target sites in various genomes, with enrichment particularly in gene promoters. However, to draw a more complete picture of the in vivo role of triplexes, not only the putative targets but also the sequences acting as the third strand and their capability to pair with the predicted target sites need to be studied. Here we present Triplexator, the first computational framework that integrates all aspects of triplex formation, and showcase its potential by discussing research examples for which the different aspects of triplex formation are important. We find that chromatin-associated RNAs have a significantly higher fraction of sequence features able to form triplexes than expected at random, suggesting their involvement in gene regulation. We furthermore identify hundreds of human genes that contain sequence features in their promoter predicted to be able to form a triplex with a target within the same promoter, suggesting the involvement of triplexes in feedback-based gene regulation. With focus on biotechnological applications, we screen mammalian genomes for high-affinity triplex target sites that can be used to target genomic loci specifically and find that triplex formation offers a resolution of ~1300 nt.
Selective permeability of PVA membranes. I. Radiation‐crosslinked membranes (1981)

Abstract The water and salt transport properties of ionizing radiation crosslinked poly(vinyl alcohol) (PVA) membranes were investigated. The studied membranes showed high permeabilities and low selectivities for both water and salt. The results were found to be in accord with a modified solution–diffusion model for transport across the membranes, in which pressure‐dependent permeability coefficients are employed.
Studies of Luminescent Conjugated Polythiophene Derivatives: Enhanced Spectral Discrimination of Protein Conformational States (2007)

Improved probes for amyloid fibril formation are advantageous for the early detection and better understanding of this disease-associated process. Here, we report a comparative study of eight luminescent conjugated polythiophene derivates (LCPs) and their discrimination of a protein (insulin) in the native or amyloid-like fibrillar state. For two of the LCPs, the synthesis is reported. Compared to their monomer-based analogues, trimer-based LCPs showed significantly better optical signal specificity for amyloid-like fibrils, seen from increased quantum yield and spectral shift. The trimer-based LCPs alone were highly quenched and showed little interaction with native insulin, as seen from analytical ultracentrifugation and insignificant spectral differences from the trimer-based LCP in buffered and native protein solution. Hence, the trimer-based LCPs showed enhanced discrimination between the amyloid-like fibrillar state and the corresponding native protein.
Doppler Flow Measurement in Coronary Artery Bypass Grafts and Early Postoperative Clinical Outcome (1994)

The present investigation attempts to correlate flow measurements made intraoperatively in coronary bypass grafts with clinical outcome. A total of 352 consecutive patients undergoing isolated coronary artery surgery underwent hemodynamic assessment of their bypass grafts (328 internal thoracic artery and 582 saphenous vein grafts) at the end of cardiopulmonary bypass (CPB) by using a 8 MHz pulsed Doppler ultrasound flowmeter. The total patient population was divided into three groups of distinct outcome (A: normal, 228 patients; B: complicated, 106 patients; C: poor, 18 patients) on the basis of a combination of the following parameters: difficult weaning from bypass, use of inotropic drugs, reduced left-ventricular stroke work index, myocardial infarction, intraaortic balloon counterpulsation, and death of cardiac origin. Univariate analysis has shown clinical outcome to be influenced by preoperative clinical condition and not by flow in bypass grafts (average flow per graft [ml/min] was 60 +/- 2 [mean +/- SEM] in group A, 58 +/- 3 in group B and 43 +/- 6 in group C: NS by analysis of variance). Multivariate analysis (Fisher linear discriminant analysis) selected only the two following factors leading to normal (group A) or adverse (groups B and C) outcome: unstable angina (p = 0.026) and duration of additional CPB after unclamping the aorta (p < 10(-5). To conclude, clinical outcome was not influenced by flow as measured in well-functioning bypass grafts by pulsed Doppler technique.
Synthetic Studies toward Diazonamide A. A Novel Approach for Polyoxazole Synthesis (2001)

[Reaction in text]The indole-bisoxazole fragment of diazonamide A was prepared by a Chan-type rearrangement of a tertiary amide. This approach represents a remarkably direct strategy for polyoxazole synthesis.
Durability of Building and Construction Sealants and Adhesives: 4th Volume (2012)

Description Twenty-five peer-reviewed papers provide the latest scientific research in the building and construction industry for all aspects of sealant and adhesive durability. Topics include: Laboratory Testing and Specialized Outdoor Exposure Testing—characterization of adhesive joints for hybrid steel-glass beams; in situ measurement of compression set in building sealants during outdoor aging; adhesive joints in glass and solar engineering; and more. Factors Influencing the Durability of Sealed Joints and Adhesive Fixing—durability of cold-bent insulating glass units; adhesion of elastomeric silicone sealants to polymeric substrates; mechanical characteristics of degraded silicone bonded point supports; glass unit corner loading; asphalt blistering on concrete bridges; interfacial durability of silicone adhesives in building applications. Development of New Test Methods and Performance-Based Specifications—quantification of surface degradation and evaluation of outdoor and accelerated exposure of construction sealants; introduction to ASTM C1736; sealed joint performance for selection of sealants suitable for autoclaved lightweight concrete panels; testing approach for structural glazing; and modulus changes during durability tests on building joint sealants. Field Experience with Sealed Joints and Adhesive Fixing—moisture sensitive adhesives and flooring adhesive failures and case studies of adhesive and rigid insulation board failures due to moisture in low sloped roofing assemblies. Performance under Seismic Loads—seismic racking test evaluation of silicone; evaluation of structural sealant in four-sided structural sealant glazing curtain wall system; and review of structural silicone glazing systems subjected to a mega-earthquake.
Assessing the Harmlessness of Federal Constitutional Error. A Process in Need of a Rationale (1976)

In Chapman v. California,' the Supreme Court announced some fundamental principles shaping the law of harmless constitutional error in criminal proceedings.First, the Court ended an aged assumption that constitutional error would always require reversal if the Supreme Court reviewed the case. 2 Next, the Court ruled that in cases containing federal constitutional error the standard of harmlessness is a federal question, not a matter of state law. 3 Finally, the Court placed the burden on "the beneficiary of a constitutional error to prove beyond a reasonable doubt that the error complained of did not contribute to the verdict obtained." 4 Although Supreme Court cases have followed these principles rather consistently since Chapman, 5 the problem of the con-
THE ELECTRODEPOSITION OF CHROMIUM, MOLYBDENUM AND TUNGSTEN (1932)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE ELECTRODEPOSITION OF CHROMIUM, MOLYBDENUM AND TUNGSTENL. F. YntemaCite this: J. Am. Chem. Soc. 1932, 54, 9, 3775–3776Publication Date (Print):September 1, 1932Publication History Published online1 May 2002Published inissue 1 September 1932https://pubs.acs.org/doi/10.1021/ja01348a503https://doi.org/10.1021/ja01348a503research-articleACS PublicationsRequest reuse permissionsArticle Views230Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: CONDENSATION OF 3‐METHYL‐O‐PHENYLENEDIAMINE WITH AROMATIC ALDEHYDES (1980)

Abstract Die 1:2‐molare Kondensation von 3‐Methyl‐o‐phenylendiamin (I) und den aromatischen Aldehyden (II) verläuft exothemi und führt zu den 1,2‐Diaryl‐substituierten und den 2‐Aryl‐substituierten Benzimidazolen (III) bzw. (IV).
Fullerenes from a Fulgurite (1993)

Peaks at 720 and 840 atomic mass units were identified by mass spectrometry in a sample extracted from a fulgurite, which is a glassy rock that forms where lightning strikes the ground. The peaks are interpreted as arising from C(60) and C(70) and the associated peaks as produced from other fullerenes. The intense conditions generated by the lightning not only melted the rock it struck and fused the associated soil but also allowed fullerenes to form, presumably from the organic debris in the soil.
Identification of Flavonoid Markers for the Botanical Origin of <i>Eucalyptus</i> Honey (2000)

European Eucalyptus honeys showed a common and characteristic HPLC profile in which the flavonoids myricetin (3,5,7,3',4', 5'-hexahydroxyflavone), tricetin (5,7,3',4',5'-pentahydroxyflavone), quercetin (3,5,7,3',4'-pentahydroxyflavone), luteolin (5,7,3', 4'-tetrahydroxyflavone), and kaempferol (3,5,7, 4'-tetrahydroxyflavone) were identified. Their contents, and relative amounts, in the analyzed honey samples were quite constant and supported their floral origin. In addition, ellagic acid and the propolis-derived flavonoids pinobanksin, pinocembrin, and chrysin were detected in most samples. The contents of these nonfloral phenolics were much more variable as could be expected for their propolis origin. Myricetin, tricetin, and luteolin had not been identified as floral markers in any other honey sample previously analyzed in our laboratory (chestnut, citrus, rosemary, lavender, acacia, rapeseed, sunflower, heather, lime tree, etc.) or reported in the literature, suggesting that these could be useful markers. Only in some individual heather samples produced in Portugal has tricetin previously been detected in minor amounts. These samples, however, were contaminated with Eucalyptus as revealed by their pollen analysis and the lack of tricetin or their glycosides in heather floral nectar. It remains to be established if myricetin, tricetin, and luteolin originate from Eucalyptus floral nectar where the corresponding glycosides should be present.
Health Effects of Coconut Oil—A Narrative Review of Current Evidence (2018)

Coconut oil is a mainstream edible oil that is extracted from the kernel of mature coconuts harvested from the coconut palm. The two main types of coconut oil-copra oil and virgin coconut oil-have similar fatty acid profiles; however the latter contains higher amounts of some nutrients (e.g., vitamin E) and dietary bioactive compounds (e.g., polyphenols). There is increasing popularity for coconut oil products due to perceived health effects of certain medium-chain fatty acids; however, lauric acid (C12:0), the primary fatty acid found in coconut oil, has been suggested to behave as both a medium- and long-chain fatty acid from a metabolic standpoint. Furthermore, research on pure medium-chain fatty acids cannot be directly applied to coconut oil products since it encompasses a large profile of various fatty acids. This narrative review seeks to summarize the current peer-reviewed literature and mechanisms surrounding the health effects of coconut oil products. Limited but consistent evidence supports the topical use for prevention and treatment of atopic dermatitis, as well as in "oil pulling" for prevention of dental caries. Coconut oil products may also be useful in preventing hair damage due to protein loss during grooming processes and ultraviolet (UV) exposure; however, more studies are needed to confirm this effect. Limited evidence does not support use for prevention or treatment of Alzheimer's disease, bone loss, or glycemic control. Evidence on weight loss and cardiovascular disease warrants larger clinical intervention studies. Refined, bleached, and deodorized copra oil seems to have less of an impact on total and low-density lipoprotein (LDL) cholesterol as compared to butter fat, but not cis unsaturated vegetable oils. In many instances, human clinical and observational studies are needed to confirm many claims on coconut oil products, which are largely based on animal and/or in vitro studies or studies of purified medium-chain fatty acids.
Secure Naïve Bayes Classification Protocol over Encrypted Data Using Fully Homomorphic Encryption (2019)

Machine learning classification has a wide range of applications. In the big data era, a client may want to outsource classification tasks to reduce the computational burden at the client. Meanwhile, an entity may want to provide a classification model and classification services to such clients. However, applications such as medical diagnosis require sensitive data that both parties may not want to reveal. Fully homomorphic encryption (FHE) enables secure computation over encrypted data without decryption. By applying FHE, classification can be outsourced to a cloud without revealing any data. However, existing studies on classification over FHE do not achieve the scenario of outsourcing classification to a cloud while preserving the privacy of the classification model, client's data and result. In this work, we apply FHE to a naïve Bayes classifier and, to the best of our knowledge, propose the first concrete secure classification protocol that satisfies the above scenario.
Remarkable regioselectivity in the chemical glycosylation of glycal acceptors: a concise solution to the synthesis of sialyl-Lewis X glycal. (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRemarkable regioselectivity in the chemical glycosylation of glycal acceptors: a concise solution to the synthesis of sialyl-Lewis X glycal.Samuel J. Danishefsky, Jacquelyn Gervay, John M. Peterson, Frank E. McDonald, Koshi Koseki, Takeshi Oriyama, David A. Griffith, Chi Huey Wong, and David P. DumasCite this: J. Am. Chem. Soc. 1992, 114, 21, 8329–8331Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/ja00047a077https://doi.org/10.1021/ja00047a077research-articleACS PublicationsRequest reuse permissionsArticle Views597Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Interactive rendering of suggestive contours with temporal coherence (2004)

Line drawings can convey shape using remarkably minimal visual content. Suggestive contours, which are lines drawn at certain types of view-dependent surface inflections, were proposed recently as a way of improving the effectiveness of computer-generated line drawings. This paper extends previous work on static suggestive contours to dynamic and real-time settings. We analyze movement of suggestive contours with respect to changes in viewpoint, and offer techniques for improving the quality of strokes rendered for a moving camera. We describe practical algorithms for rendering drawings with contours and suggestive contours at interactive rates. Finally, we discuss techniques for improving the visual appearance of suggestive contours, in both the static and dynamic cases.
Imaging Individual Proteins and Nanodomains on Intact Cell Membranes with a Probe‐Based Optical Antenna (2009)

Optical antennas that confine and enhance electromagnetic fields in a nanometric region hold great potential for nanobioimaging and biosensing. Probe-based monopole optical antennas are fabricated to enhance fields localized to <30 nm near the antenna apex in aqueous conditions. These probes are used under appropriate excitation antenna conditions to image individual antibodies with an unprecedented resolution of 26 +/- 4 nm and virtually no surrounding background. On intact cell membranes in physiological conditions, the obtained resolution is 30 +/- 6 nm. Importantly, the method allows individual proteins to be distinguished from nanodomains and the degree of clustering to be quantified by directly measuring physical size and intensity of individual fluorescent spots. Improved antenna geometries should lead to true live cell imaging below 10-nm resolution with position accuracy in the subnanometric range.
New Schools for the Disadvantaged. (1987)

This paper outlines the types of schooling programs that will build on the strengths of educationally disadvantaged students to bring them into the educational mainstream as well as to prepare them for economic, political, and social participation. Without intervention on behalf of the disadvantaged, the following results may occur: (1) a dual society with a large uneducated underclass; (2) disruption in higher education; (3) national economic deterioration; and (4) rising costs of public services. The educational plight of the disadvantaged is outlined. Any strategy for improving their situation must begin at the elementary level, and must be dedicated to preparing students for doing high quality work in secondary school. Such a strategy is the Accelerated School, a transitional elementary school that brings disadvantaged children up to grade level by the completion of the sixth grade. The following aspects of the Accelerated School are discussed: (1) school-based governance; (2) goals; (3) pupil and school assessment; (4) nutrition and health; (5) curriculum; (6) instructional strategies; (7) comcunity resources; (8) parental participation and training; and (9) extended daily session. The major organizational dimensions of change required for transforming schools into accelerated learning institutions are discussed, and steps to assist the transformation are suggested. An 18-item list of references is included. (BJV) ************************************************ ***** ****************** * , Reproductions supplied by EDRS are the best that can be made from the original document. U 5 DEPARTMENT Of EDUCATION Office of Educational Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER IERICI )4. TMS document has been reproduced an ' received trom the person or organizatiJi originating it 0 Minor changes have been made to improve reproduction quality Points of . ew or opinions slated in thiSdocu ment do not necessarily represent off.oal OERI posItion or policy g/3--$.9 PERMISSION TO REPRODUCE THIS MATERIAL HAS BEEN GRANTED BY 4-16,1 ri , Leu,,,, Sta-iPord Okiv TO THE EDUCATIONAL RESOURCES INFORMATION CFNTER (ERIC) NEW SCHOOLS FOR THE DISADVANTAGED