gebhart/patrepeval huggingface dataset:
Study of cutaneous wound healing in rats treated with Lactobacillus plantarum on days 1, 3, 7, 14 and 21 (2011)

Probiotics are microorganisms in the gastrointestinal tract that help the immune system and reduce inflammation. The beneficial effects of these bacteria on ulcer healing have been proved but little research has been done in the field of cutaneous wound healing. Therefore, the purpose of this experiment is to study the effect of Lactobacillus plantarum on cutaneous wound healing. Some strains of Lactobacillus isolated from traditional dairy products of Iran are investigated for exopolysaccharide (EPS) production applying the phenol-sulfuric acid method. L. plantarum was selected for its high exopolysaccharide and mucoid coloniese production. Wistar male rats divided into 3 groups; Experimental, control and negative control (n = 5) and a full-thickness wound (1.5 × 1.5 cm) was made on the back of each rat (45 rats in 3 groups). After 24 h of injury, two groups, control and experimental, were treated by eucerin, and eucerin contained L. plantarum, respectively, but the negative-control group did not receive anything. On days 1, 3, 7, 14 and 21, rats were killed and wound samples were collected for histological and statistical studies. L. plantarum significantly decreased wound area as compared to other groups and increased wound healing. Histological study on day 3 showed significant increase in the number of neutrophils and significant increases in macrophages and fibroblasts (p < 0.001). Also significant reduction in neutrophils, macrophages and fibroblasts numbers was observed on day 21 (p < 0.001). The current study presented a significant decrease in inflammation and an acceleration of wound healing in L. plantarum treated rats.
The Advantages of Controlled Atmospheres for Arc Spectroscopy (1953)

Effective spectrochemical analysis depends upon three components of the apparatus. Two of them, the detector (including such elements as plates and photocells), and the light disperser (including prisms, gratings, and now echelles) are relatively well understood and perfected. The third and most significant of the three, the light source, has proved a more difficult problem. One line of attack used fairly recently, however, has been on the atmosphere around the arc. Air, the usual medium, has one major failing, namely, the interference of the cyanogen bands accompanying the reaction between atmospheric nitrogen and the electrode carbon. Other gases used in place of air not only overcome this disadvantage, but provide several additional advantages which may prove to be as important as they were unexpected. The reasons for these gains are still not understood, and painstaking trial-and-error selection of the best medium for a particular analysis is still necessary. Nevertheless the gains realized from operating a source in artificial atmospheres are frequently great enough to justify each analyst in trying all available gases for his own peculiar circumstances, problems, and apparatus. In addition to the control of source environment by varying the gas around the arc another approach to the problem is possible: that of varying the pattern of the gas flow around the arc.
Migration of O‐acetyl groups in N,O‐acetylneuraminic acids (1987)

Highly purified N-acetyl-4-O-acetylneuraminic acid (Neu4,5Ac2), N-acetyl-7-O-acetylneuraminic acid (Neu5,7Ac2) and N-acetyl-7,9-di-O-acetylneuraminic acid (Neu5,7,9Ac3) were used to study spontaneous migrations of acetyl groups between hydroxyl groups. The techniques applied involved thin-layer chromatography, gas-liquid chromatography/mass spectrometry, high-performance liquid chromatography and 360-MHz 1H-NMR spectroscopy. It was found that at pH values at which no significant de-O-acetylation is observed: (a) Neu5,7Ac2 can easily be transformed into Neu5,9Ac2, (b) Neu5,7,9Ac3 yields an equilibrium of Neu5,7,9Ac3 and Neu5,8,9Ac3 in a molar ratio of approximately 1:1, and (c) Neu4,5Ac2 does not give rise to O-acetyl migrations. The importance of these findings is discussed in terms of the biosynthesis of O-acetylated sialic acids.
Kinetic and Structural Basis for Acyl-Group Selectivity and NAD<sup>+</sup> Dependence in Sirtuin-Catalyzed Deacylation (2015)

Acylation of lysine is an important protein modification regulating diverse biological processes. It was recently demonstrated that members of the human Sirtuin family are capable of catalyzing long chain deacylation, in addition to the well-known NAD(+)-dependent deacetylation activity [Feldman, J. L., Baeza, J., and Denu, J. M. (2013) J. Biol. Chem. 288, 31350-31356]. Here we provide a detailed kinetic and structural analysis that describes the interdependence of NAD(+)-binding and acyl-group selectivity for a diverse series of human Sirtuins, SIRT1-SIRT3 and SIRT6. Steady-state and rapid-quench kinetic analyses indicated that differences in NAD(+) saturation and susceptibility to nicotinamide inhibition reflect unique kinetic behavior displayed by each Sirtuin and depend on acyl substrate chain length. Though the rate of nucleophilic attack of the 2'-hydroxyl on the C1'-O-alkylimidate intermediate varies with acyl substrate chain length, this step remains rate-determining for SIRT2 and SIRT3; however, for SIRT6, this step is no longer rate-limiting for long chain substrates. Cocrystallization of SIRT2 with myristoylated peptide and NAD(+) yielded a co-complex structure with reaction product 2'-O-myristoyl-ADP-ribose, revealing a latent hydrophobic cavity to accommodate the long chain acyl group, and suggesting a general mechanism for long chain deacylation. Comparing two separately determined co-complex structures containing either a myristoylated peptide or 2'-O-myristoyl-ADP-ribose indicates there are conformational changes at the myristoyl-ribose linkage with minimal structural differences in the enzyme active site. During the deacylation reaction, the fatty acyl group is held in a relatively fixed position. We describe a kinetic and structural model to explain how various Sirtuins display unique acyl substrate preferences and how different reaction kinetics influence NAD(+) dependence. The biological implications are discussed.
A novel approach to extracting small-signal model parameters of silicon MOSFET's (1997)

We present a simple and accurate method to extract a small-signal equivalent circuit model of Si MOSFET's, based on the novel approach to determining parasitic inductances and resistances by fitting the frequency response of new analytic expressions with Z-parameters. This method is proposed to overcome the serious problem that conventional cold-FET methods cannot be applied for MOSFET's, and is also superior to the traditional optimization of the entire model parameters to fit the measured S-parameters. In particular, this technique is simple and reliable because no additional measurements are needed. The excellent correspondence is achieved between modeled and measured S-parameters from 0.5 to 39.5 GHz.
Diamond and diamond‐like carbon (1991)

Research News/Diamond Thin Film Technology IIb : The second part of this article continues the description of work presented at a two‐week Advanced Study Institute held in the mountains of Tuscany. Topics under discussion were deposition methods, deposition parameters, and applications, including cutting tool inserts, armored IR optics, and X‐ray detector windows.
Interferon-γ down-regulates expression of tumor necrosis factor-α converting enzyme/a disintegrin and metalloproteinase 17 in activated hepatic stellate cells of rats (2006)

Interferon-gamma (IFN-gamma) is a potent cytokine that exerts antiproliferative and antifibrogenic effects on hepatic stellate cells (HSCs). Although therapeutic application of IFN-gamma for chronic liver diseases is anticipated, the responses of activated HSCs to IFN-gamma have not been fully elucidated. To seek unknown molecules and pathways that might be responsive to IFN-gamma treatment in activated HSCs, we examined global protein expression profiles using two-dimensional gel electrophoresis combined with peptide mass fingerprint. We identified 76 increased and 59 decreased spots (>3-fold increase or decrease, total 135 spots). Database analysis suggested that the following four pathways were involved in alteration of HSCs toward a quiescent phenotype in response to IFN-gamma: i) down-regulation of the TGF-beta and PDGF signaling pathways; ii) reorganization of intermediate filaments; iii) up-regulation of fatty acid metabolism; iv) decreased expression of TNF-alpha converting enzyme (TACE)/a disintegrin and metalloproteinase 17 (ADAM17), which is responsible for shedding of the proinflammatory cytokine TNF-alpha. We confirmed down-regulation of both ADAM17 expression and soluble TNF-alpha secretion by Western blotting and real-time PCR. TNF-alpha mRNA/protein expression was not altered by IFN-gamma treatment. Our data suggest that IFN-gamma stimulation suppresses the activated phenotype of HSCs in vitro through multiple pathways. Of these pathways, down-regulation of ADAM17 expression may play a role in blocking the auto-activation mechanism of cultured HSCs through activation of the TNF-alpha signaling and shedding pathways.
The direct and sustained consequences of severe placental hypoxia on vascular contractility (2018)

Both the acute vasoconstriction, as well as the increased contractility to U46619 are in line with the clinical vascular complications observed in preeclampsia. Data obtained with quercetin supports that our model opens avenues for e.g. nutritional interventions aimed at treating or preventing preeclampsia.
Modelling concepts for intelligent vehicle highway systems (IVHS) applications (1992)

The Federal Highway Administration (FHWA) in cooperation with other government agencies, private industry, and academia, has established the Intelligent Vehicle Highway Systems (IVHS) program to use advanced computer and communications technology to increase throughput on existing roadways, to improve the safety of the traveling public, and to improve productivity of vehicle operations. Communications and vehicle traffic control are two major technologies used directly or indirectly to support the above IVHS program. This paper describes vehicle traffic and communications system modeling concepts used to analyze IVHS applications. The modeling concepts for IVHS traffic analysis section focuses on issues, solutions, and the design principles of an object-oriented model. The modeling concepts for communications system analysis section discusses Commercial Vehicle Operations (CVO) related architecture alternatives and performance analysis considerations.
Broadcast Video Logo Detection and Removing (2008)

Video logos can be considered as a form of visible watermark which is a trademark or symbol to declare the video copyright. However, in some cases, it will cause visual discomfort due to the presence of multiple logos overlapped directly or blended with another logo in videos. In this paper, we use an efficient gradient- based average approach to detect the logo firstly; then, the selected logo mask in the entire video sequence will be inpainted by the spatial-temporal image restoration technique. Experimental results show that our method is capable of recovering various kinds of video logos in the visually plausible way.
Mayer'S Hemalum-Methyl Salicylate: A Stain-Clearing Technique for Observations Within Whole Ovules (1984)

Nondissected ovaries of tuber-bearing Solanum sp. were stained with Mayer's hemalum, a positive stain for chromatin and nucleoli, and then optically cleared with methyl salicylate, a clearing agent. Clarity, resolution and contrast within the ovules dissected from ovaries were comparable to those of sectioned, paraffin embedded ovaries. Contrast within ovules greatly exceeded that of unstained and nonspecifically stained clearings, and eliminated the need of special optics, i.e., Nomarski interference-contrast optics, for optimal viewing and photography. Much less time and labor were required than for embedded specimens. Usefulness of the technique for cytogenetic and cytological research was verified by analyzing meiosis and other features of megasporogenesis and megagametogenesis in normal, and in two meiotic mutants, of Solanum. The results illustrate the usefulness of combined Mayer's hemalum staining and methyl salicylate clearing, and suggest additional stain-clearing agent combinations have potential for cytological and cytogenetic research. Preliminary results with other species suggest the technique may also be useful for classroom instruction.
Interactions between Hb, Mg, DPG, ATP, and Cl determine the change in Hb-O2 affinity at high altitude (1993)

Ascent to high altitude (HA) causes an increase in erythrocyte 2,3-diphsophoglycerate (DPG) and standard PO2 at 50% O2 saturation, PCO2 40 Torr, and blood pH 7.4 (P50,st). We studied the early phase of acclimatization to HA of mountaineers without and with a history of HA pulmonary edema. Tests were performed before ascent and after arrival at HA (4,559 m), approximately 22 h after the departure from low altitude (HA1) and on the following 3 days at HA (HA2-HA4). We investigated the relation between changes in DPG and P50,st, since at moderate altitude P50,st increases more rapidly than DPG, indicating that other factors may contribute to the change in P50,st. Combined effects of interaction between allosteric effectors of hemoglobin (Hb) (DPG, ATP, Cl) and Mg, which competes with Hb for DPG and ATP binding, might explain that phenomenon. Therefore concentrations of liganded Hb species were calculated from the total erythrocyte concentrations of the ligands by use of published binding constants and were related to changes in Hb-O2 affinity. P50,st increased at HA by approximately 4.5 Torr; the concentration of total DPG and ATP increased by 28 and 19%, respectively. Whereas P50,st reached a plateau already at HA1, the concentration of DPG reached its highest value at HA4. The erythrocyte Cl concentration decreased, whereas cellular Hb and Mg concentrations increased slightly. The sum of concentrations of all liganded Hb species increased, reaching 79% of its total change within 22 h after ascent; this can mainly be attributed to the change in the concentration of Hb[DPG] (+77% of total increase).(ABSTRACT TRUNCATED AT 250 WORDS)
Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes (2005)

Conditions are reported for the facile, high-yielding coupling of acyl chlorides with terminal alkynes in a reaction involving palladium and copper iodide; the reaction is tolerant of a wide variety of acyl chlorides and terminal alkynes and provides a convenient one-pot route to acetylenic ketones.
A Nonlinear Effect of Hyperglycemia and Current Cigarette Smoking Are Major Determinants of the Onset of Microalbuminuria in Type 1 Diabetes (2001)

Cigarette smoking and poor glycemic control are risk factors for diabetic nephropathy in type 1 diabetes. However, the specifics of the relation of these risk factors to the onset of this complication have not been elucidated. To investigate these issues, we followed for 4 years 943 Joslin Clinic patients aged 15-44 years with type 1 diabetes who had normoalbuminuria during the 2-year baseline period. Microalbuminuria developed in 109 of the 943 individuals, giving an incidence rate of 3.3/100 person-years. The risk of onset of microalbuminuria was predicted somewhat more precisely by the measurements during the 1st and 2nd years preceding onset than by all the measurements during the longer (4-year) interval, suggesting attenuation of the impact of past hyperglycemia over time. Point estimates of the incidence rate (per 100 person-years) according to quartiles of HbA(1c) during the 1st and 2nd years preceding the outcome were 1.3 in the 1st, 1.5 in the 2nd, 3.1 in the 3rd, and 6.9 in the 4th (P = 1.3 x 10(-9)). Point estimates of the incidence rate (per 100 person-years) according to smoking status were 7.9 for current smokers, 1.8 for past smokers, and 2.2 for those who had never smoked (P = 2.0 x 10(-7)). In a multiple logistic model, the independent effects of HbA(1c) level and cigarette smoking remained highly significant, but their magnitudes were reduced. Using the same covariates in a generalized additive model, we examined the shape of the relationship between HbA(1c) and onset of microalbuminuria and found significant nonlinearity in the logarithm of odds scale (P = 0.04). The slope was steeper with HbA(1c) >8% than <8%. Furthermore, the change in the slope was magnified among current smokers. In conclusion, patients with type 1 diabetes who smoke and have an HbA(1c) >8% have the highest risk of onset of microalbuminuria.
A Hamming distance based test pattern generator with improved fault coverage (2005)

This paper proposes a new test pattern generator (TPG) which is an enhancement of GLFSR (Galois LFSR). This design is based on certain non-binary error detecting codes, formulated over an extension field of GF(2/sup /spl delta//), /spl delta/ > 1. The resulting generator provides a guaranteed Hamming distance between successive test patterns, resulting in shorter test lengths. As an additional advantage, the proposed TPG has the intrinsic ability to detect 1-bit errors in the TPG itself. Detailed design methodology and experimental results are presented. The results presented here also have implications in algebraic coding theory in that they may lead to new coding techniques for test pattern generation.
Morfologia y biologia de Bostryx conspersus (Sowerby) (Mollusca, Bulimulidae) en las lomas costeras del Peru Central (1988)

Morphological and biological observations on populations of the land snailBostryx conspersus, in three ''Lomas'' af the Central Coast of Peru, were carried out between 1979 and 1982.Three shell color varieties of B. conspersus are reparted herein, as wel/ as its aestivation, activity and reproduction strategies.The possible interactions of B. conspersus with a dipteron (Scaptomyza sp.; Drosophilidae) and a nematode species are also discussed.
N-Allylnorapomorphine<sup>1a</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-Allylnorapomorphine1aJerome F. Hensiak, Joseph G. Cannon, and Allan M. BurkmanCite this: J. Med. Chem. 1965, 8, 5, 557–559Publication Date (Print):September 1, 1965Publication History Published online1 May 2002Published inissue 1 September 1965https://pubs.acs.org/doi/10.1021/jm00329a001https://doi.org/10.1021/jm00329a001research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hepatic Fat Fraction: MR Imaging for Quantitative Measurement and Display—Early Experience (2005)

radiology.rsnajnls.org/cgi/content/full/2373041639/DC1
THE TREATMENT OF PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS (2000)

Nephrotic patients with primary focal segmental glomerulosclerosis (FSGS) have a poor prognosis with 50% progressing to end stage renal disease (ESRD) over 3 to 8 years. The achievement of a remission in proteinuria has been associated with a significantly improved renal survival as compared to those patients not attaining a remission. Unfortunately, spontaneous remissions are rare in FSGS, and the response to therapy has historically been poor. Recent experience with more aggressive immunosuppressive therapy has lead to an increase in the remission rate for FSGS patients and given rise to optimism in the treatment of this glomerulopathy.
The utilization of urea in the bovine rumen. 2. The conversion of urea to ammonia (1943)

Research Article| April 01 1943 The utilization of urea in the bovine rumen. 2. The conversion of urea to ammonia R. M. Pearson; R. M. Pearson 1The Hannah Dairy Research Institute, Kirkhill, Ayr Search for other works by this author on: This Site PubMed Google Scholar J. A. B. Smith J. A. B. Smith 1The Hannah Dairy Research Institute, Kirkhill, Ayr Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd © 1943 CAMBRIDGE UNIVERSITY PRESS1943 Biochem J (1943) 37 (1): 148–153. https://doi.org/10.1042/bj0370148 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation R. M. Pearson, J. A. B. Smith; The utilization of urea in the bovine rumen. 2. The conversion of urea to ammonia. Biochem J 1 April 1943; 37 (1): 148–153. doi: https://doi.org/10.1042/bj0370148 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1943 CAMBRIDGE UNIVERSITY PRESS1943 Article PDF first page preview Close Modal You do not currently have access to this content.
<i>In vitro</i> platelet interactions in whole human blood exposed to biomaterial surfaces: Insights on blood compatibility (1993)

A short-term in vitro test to study platelet interactions with biomaterials is described. Using fresh human blood and a modified Chandler loop system, beta-thromboglobulin release was measured. Also, adherent platelets were observed by using scanning electron microscopy (SEM) and a colorimetric stain specific for human platelet GPIIIa. Materials studied in these experiments were polyethylene (PE), Biomer, poly(vinyl alcohol) (PVA), and a polyurethane prepared with octadecyl pendant groups (ODCE). Four blood reactions were observed: (1) Platelets continually adhere and activate on the Biomer; (2) platelets initially adhere and activate but then spread to a thin, passivating film on the PE; (3) platelets do not adhere to the PVA surface but continually react with it upon contact; and (4) platelets neither adhere to nor activate on the ODCE surface. Reactions (2) and (4) are considered characteristic of blood-compatible materials.