gebhart/patrepeval huggingface dataset:
Acute endoneurial ischemia induced by epineurial endothelin in the rat sciatic nerve (1992)

Endothelin (ET) is a potent vasoconstrictor peptide that may have pathophysiological roles in the microcirculation of the peripheral nervous system. We examined the local action of epineurial ET-1 on sciatic endoneurial blood flow using serial hydrogen clearance measurements in anesthetized, paralyzed, and ventilated Sprague-Dawley rats. In separate rats, we made serial measurements of sciatic motor multifiber conduction before and then after application of epineurial ET (saline on contralateral nerve) 2 and 24 h and 4 and 7 days later. Epineurial bathing solutions of ET increased microvascular resistance and reduced local endoneurial blood flow in a dose-responsive fashion with a half-maximum effective concentration of 10(-8) M. Maximum vasoconstriction at 10(-6) M ET was associated with a fall in endoneurial blood flow from 18.7 (pre-ET) to 7.2 ml x 100 g-1 x min-1. Epineurial norepinephrine (10(-7) to 10(-10) M) also resulted in vasoconstriction, but of lesser degree. Pretreatment with intraperitoneal nimodipine, a dihydropyridine Ca2+ channel antagonist, but not phentolamine, prevented the vasoconstrictive action of ET. Three of eight animals developed temporary but complete axonal conduction block at the site of ET administration (10(-5) M) and four others had partial conduction block. Contralateral saline-treated sciatic fibers were unaffected. Local ET action on extrinsic epineurial microvessels results in reversible ischemia of the underlying endoneurium that may be associated with conduction block. ET's action is more potent than norepinephrine and appears dependent on L-type voltage-gated Ca2+ channels.
A 2.5 Gb/s Run-Length-Tolerant Burst-Mode CDR Based on a 1/8th-Rate Dual Pulse Ring Oscillator (2008)

A 2.5 Gb/s burst-mode clock and data recovery (CDR) circuit is presented that uses a 1/8th-rate ring oscillator with two pulses running simultaneously that are phase independent. One ldquotunerdquo pulse sets the delay of the ring by phase locking it to a reference. The other ldquoclockrdquo pulse tracks the phase of the incoming data by a process of pulse removal and reinsertion. Because both pulses share the same ring, there is no frequency mismatch between the incoming data stream and the recovered clock in frequency synchronous systems, allowing for large data run lengths. A 1:8 data-demux clock is naturally generated by tapping the clock pulse along the ring. Phase acquisition is instantaneous from a single data edge. Run length tolerance is larger than 72 bits. The 0.6 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> 0.13 mum CMOS chip includes a CML-to-CMOS input buffer, PLL with on-chip loop filter, PRBS checker, 1:8 data demux, and eight output buffers. It has 2.7 UI <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> measured jitter tolerance at 100 kHz and consumes 42 mW from a single 1.2 V supply.
A capacitance solver for incremental variation-aware extraction (2008)

Lithographic limitations and manufacturing uncertainties are resulting in fabricated shapes on wafer that are topologically equivalent, but geometrically different from the corresponding drawn shapes. While first-order sensitivity information can measure the change in pattern parasitics when the shape variations are small, there is still a need for a high-order algorithm that can extract parasitic variations incrementally in the presence of a large number of simultaneous shape variations. This paper proposes such an algorithm based on the well-known method of floating random walk (FRW). Specifically, we formalize the notion of random path sharing between several conductors undergoing shape perturbations and use it as a basis of a fast capacitance sensitivity extraction algorithm and a fast incremental variational capacitance extraction algorithm. The efficiency of these algorithms is further improved with a novel FRW method for dealing with layered media. Our numerical examples show a 10X speed up with respect to the boundary-element method adjoint or finite-difference sensitivity extraction, and more than 560X speed up with respect to a non-incremental FRW method for a high-order variational extraction.
[Effect of NAD and cytochrome C on the energy supply system and ultrastructure of cardiomyocytes in toxic-allergic myocarditis]. (1993)

The level of NAD was decreased while the NADH/NAD ratio was increased in the myocardium of rabbits with 10-day toxic-allergic myocarditis. The concentrations of ATP, ADP, AMP and especially of creatine phosphate were decreased in the myocardium. At the same time, inter- and intracellular edema was developed and the cardiomyocyte structure was impaired. After administration of NAD in a dose of 0.5 mg/kg of body mass, the content and ratio of pyridine nucleotides as well as content of ATP and AMP were completely normalized, while content of ADP exceeded the control values but creatine phosphate was maintained at a low level. Cardiomyocytic ultrastructure was distinctly improved. Cytochrome c, administered at a dose of 5 mg/kg of body mass, did not affect markedly the pyridine nucleotides ratio but increased slightly their total content. The adenylic nucleotides and creatine phosphate were distinctly increased as well as cardiomyocyte ultrastructure was considerably improved.
Effects of argon gas flow rate and guide shell on oxygen concentration in Czochralski silicon growth (2006)

ø200 mm silicon single crystals were grown in the ø450 mm hot zone of a Czochralski (CZ) furnace. By modifying the pattern and the velocity of the argon flow, the silicon single crystals with different oxygen concentrations were obtained. Through numerical simulation, the velocity of the argon gas flow was plotted for the first time. The experiment results were analyzed and the optimum condition of the argon flow with the lowest oxygen concentration was obtained.
Mutations in the gyrA gene of a highly fluoroquinolone-resistant clinical isolate of Escherichia coli (1993)

We have determined the DNA sequence of the gyrA gene of the fluoroquinolone-resistant Escherichia coli isolate 205096 (MIC of ciprofloxacin, 128 micrograms/ml), which was recently demonstrated to be a gyrA mutant (P. Heisig and B. Wiedemann, Antimicrob. Agents Chemother. 35:2031-2036, 1991). Compared with the gyrA+ gene of E. coli K-12, 55 nucleotide changes were found. Three of these resulted in amino acid exchanges: Ser-83-->Leu, Asp-87-->Gly, and Asp-678-->Glu. A 0.7-kb DNA fragment containing two of these mutations (Ser-83-->Leu and Asp-87-->Gly) was isolated and fused in frame to the residual 3' coding region of gyrA+ in a plasmid to yield a chimeric gyrA gene (gyrA#). After introduction into E. coli 205096, this gyrA# gene does not increase the fluoroquinolone susceptibility of the resulting heterodiploid strain in a dominance test, while the gyrA+ gene does. The ciprofloxacin concentration necessary to inhibit by 90% (IC90) the supercoiling activity of gyrase isolated from E. coli 205096 is above 2,000 micrograms/ml. An identical result was found for gyrase reconstituted in vitro from the gyrB+ gene product and the chimeric gyrA# gene product. This is more than a 4,000-fold increase compared with the IC90 determined for gyrase from E. coli K-12 (gyrA+) (IC90, 0.5 microgram of ciprofloxacin per ml). No indications for the involvement of the gyrB gene or for alterations in quinolone permeation were found.
Diet‐Induced Obesity Resistance of Kv1.3−/− Mice is Olfactory Bulb Dependent (2012)

Gene-targeted deletion of the voltage-gated potassium channel, Kv1.3 (Kv1.3-/-), increases olfactory sensitivity and discriminatory ability, and causes resistance to diet-induced obesity (DIO) in mice. The present study aimed to determine whether the enhanced olfactory ability of the Kv1.3-/- mouse contributes to the resistance to DIO. Kv1.3+/+ and Kv1.3-/- mice were subject to bilateral olfactory bulbectomy (OBX) or sham surgery at 9 weeks of age and placed on either a control chow diet or a 32% moderately high-fat diet (MHF). Caloric and water intake, locomotor activity and oxygen consumption were monitored after 5 weeks of diet treatment. At the end of 26 weeks of diet treatment, fat pad weight and blood chemistry were evaluated. Kv1.3+/+ mice exhibited a significant increase in weight, adiposity, fasting glucose and fasting leptin in response to the MHF-diet, with or without OBX. When treated with a MHF-diet, Kv1.3-/- mice gained significantly less weight than Kv1.3+/+ mice and exhibited a significant increase in light phase metabolism. OBX of Kv1.3-/- mice prevented the resistance to DIO and concomitant up-regulation of light phase metabolism at the same time as decreasing dark phase metabolism and total energy expenditure. These findings suggest that pathways activated in Kv1.3-/- that increased energy expenditure and led to resistance to DIO are olfactory bulb dependent. Thus, these findings add to a growing body of evidence suggesting that the olfactory system can modulate the pathways involved in the regulation of energy balance.
Convex shape decomposition (2010)

In this paper, we propose a new shape decomposition method, called convex shape decomposition. We formalize the convex decomposition problem as an integer linear programming problem, and obtain approximate optimal solution by minimizing the total cost of decomposition under some concavity constraints. Our method is based on Morse theory and combines information from multiple Morse functions. The obtained decomposition provides a compact representation, both geometrical and topological, of original object. Our experiments show that such representation is very useful in many applications.
Association of Fiber Quality Parameters and Within‐Boll Yield Components in Upland Cotton (1997)

Lint yield and fiber quality in upland cotton, Gossypium hirsutum L., are interrelated through a series of individual components such as fiber length and the number of fibers produced on each seed. Numerous studies have reported the relationships among various components of yield and yield per unit land area, but none have reported on the relationships among the most basic within‐boll yield components and fiber quality parameters. The objectives of this study were (i) to determine the association of fiber quality parameters with basic within‐boll yield components for six diverse cotton genotypes and (ii) to determine if repulsion phase linkage explained the high negative correlations reported among fiber quality parameters and lint yield. The second objective was investigated by comparing the associations of fiber length, strength, and micronaire with within‐boll yield components among selected F 1 populations developed by mating parents with similar direction of general combining ability (GCA) for fiber quality and within‐boll lint yield components with selected F 1 populations derived by mating parents with dissimilar direction of GCA. Parents and F 1 s were grown at College Station, TX, in 1989 and 1992. Fiber quality parameters were determined by high volume instrumentation. Within‐boll lint yield components were determined by direct measurement or through calculations. Fiber strength and length were negatively associated with the most basic within‐boll lint yield components. Repulsion phase linkage appears to play a role in the negative association of fiber quality and within‐boll lint yield but pleiotropic effects could not be ruled out.
Aminoglycosylation Can Enhance the G-Quadruplex Binding Activity of Epigallocatechin (2013)

With the aim of enhancing G-quadruplex binding activity, two new glucosaminosides (16, 18) of penta-methylated epigallocatechin were synthesized by chemical glycosylation. Subsequent ESI-TOF-MS analysis demonstrated that these two glucosaminoside derivatives exhibit much stronger binding activity to human telomeric DNA and RNA G-quadruplexes than their parent structure (i.e., methylated EGC) (14) as well as natural epigallocatechin (EGC, 6). The DNA G-quadruplex binding activity of 16 and 18 is even more potent than strong G-quadruplex binder quercetin, which has a more planar structure. These two synthetic compounds also showed a higher binding strength to human telomeric RNA G-quadruplex than its DNA counterpart. Analysis of the structure-activity relationship revealed that the more basic compound, 16, has a higher binding capacity with DNA and RNA G-quadruplexes than its N-acetyl derivative, 18, suggesting the importance of the basicity of the aminoglycoside for G-quadruplex binding activity. Molecular docking simulation predicted that the aromatic ring of 16 π-stacks with the aromatic ring of guanine nucleotides, with the glucosamine moiety residing in the groove of G-quadruplex. This research indicates that glycosylation of natural products with aminosugar can significantly enhance their G-quadruplex binding activities, thus is an effective way to generate small molecules targeting G-quadruplexes in nucleic acids. In addition, this is the first report that green tea catechin can bind to nucleic acid G-quadruplex structures.
Efficient broadcast frequency utilization - a key to high capacity cellular networks (2003)

Broadcast frequencies (or common control channels) are fundamental components of any cellular network. They define cellular coverage, carry vital system information, and are used for the link quality measurements that govern cell selection and handover, collectively known as "locating". Unfortunately, they can also be a capacity bottleneck and their efficient utilization is a key issue for high capacity networks. In this study, we consider methods for maximizing broadcast (or BCCH) frequency efficiency in the world's most widely used cellular technology, GSM, in which the introduction of 3G multimedia services through EDGE is making the efficient use of radio resources more crucial than ever before. We show that a very tight BCCH reuse is achievable through intelligent channel management and an optimized cell plan. Further, we present a novel modification to the GSM neighbor cell measurement technique that dramatically decreases its dependency on BCCH reuse and significantly improves locating performance.
3‐D prestack f‐x coherent noise suppression (1995)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 19953‐D prestack f‐x coherent noise suppressionAuthors: James E. GaiserJames E. GaiserWestern Geophysical Companyhttps://doi.org/10.1190/1.1887288 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1887288FiguresReferencesRelatedDetailsCited ByHighly aliased ground-roll suppression using a 3D multiwindow Karhunen-Loève filter: Application to a legacy Mississippi Lime surveySumit Verma, Shiguang Guo, Thang Ha, and Kurt J. Marfurt28 January 2016 | GEOPHYSICS, Vol. 81, No. 1Scattered ground-roll attenuation using model-driven interferometry21 October 2014 | Geophysical Prospecting, Vol. 63, No. 1Adaptive interferometry for ground-roll suppressionThe Leading Edge, Vol. 30, No. 5Acquisition geometries for model‐driven interferometric ground‐roll removalDavid Halliday, Ed Kragh, Phil Bilsby, and John Quigley8 August 2011Adaptive model‐driven interferometry for ground‐roll attenuationDavid Halliday21 October 20103D ground roll suppressionCheng‐shu Wang10 February 20052D/3D coherent noise attenuation by locally adaptive modeling and removal on prestack data22 March 2012 SEG Technical Program Expanded Abstracts 1995ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1995 Pages: 1566 publication data© 1995 Copyright © 1995 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION James E. Gaiser, (1995), "3‐D prestack f‐x coherent noise suppression," SEG Technical Program Expanded Abstracts : 1354-1357. https://doi.org/10.1190/1.1887288 Plain-Language Summary PDF DownloadLoading ...
Input-output parametric models for non-linear systems Part I: deterministic non-linear systems (1985)

Recursive input-output models for non-linear multivariate discrete-time systems are derived, and sufficient conditions for their existence are defined. The paper is divided into two parts. The first part introduces and defines concepts such as Nerode realization, multistructural forms and results from differential geometry which are then used to derive a recursive input-output model for multivariable deterministic non-linear systems. The second part introduces several examples, compares the derived model with other representations and extends the results to create prediction error or innovation input-output models for non-linear stochastic systems. These latter models are the generalization of the multivariable ARM AX models for linear systems and are referred to as NARMAX or Non-linear AutoRegressive Moving Average models with exogenous inputs.
Towards a Model Based Security Testing Approach of Cloud Computing Environments (2012)

In recent years Cloud computing became one of the most aggressively emerging computer paradigms resulting in a growing rate of application in the area of IT outsourcing. However, as recent studies have shown, security most of the time is the one requirement, neglected at all. Yet, especially because of the nature of usage of Cloud computing, security is inevitable. Unfortunately, assuring the security of a Cloud computing environment is not a one time task, it is a task to be performed during the complete lifespan of the Cloud. This is motivated by the fact that Clouds undergo daily changes in terms of newly deployed applications and offered services. Based on this assumption, in this paper, we propose a novel model -- based, change -- driven approach, employing risk analysis, to test the security of a Cloud computing environment among all layers. As a main intrusion point, our approach exploits the public service interfaces, as they are a major source of newly introduced vulnerabilities, possibly leading to severe security incidents.
Adjuvant Therapy in Stage I and Stage II Epithelial Ovarian Cancer (1990)

About a third of patients with ovarian cancer present with localized disease; despite surgical resection, up to half the tumors recur. Since it has not been established whether adjuvant treatment can benefit such patients, we conducted two prospective, randomized national cooperative trials of adjuvant therapy in patients with localized ovarian carcinoma (International Federation of Gynecology and Obstetrics Stages Ia to IIc). All patients underwent surgical resection plus comprehensive staging and, 18 months later, surgical re-exploration. In the first trial, 81 patients with well-differentiated or moderately well differentiated cancers confined to the ovaries (Stages Iai and Ibi) were assigned to receive either no chemotherapy or melphalan (0.2 mg per kilogram of body weight per day for five days, repeated every four to six weeks for up to 12 cycles). After a median follow-up of more than six years, there were no significant differences between the patients given no chemotherapy and those treated with melphalan with respect to either five-year disease-free survival (91 vs. 98 percent; P = 0.41) or overall survival (94 vs. 98 percent; P = 0.43). In the second trial, 141 patients with poorly differentiated Stage I tumors or with cancer outside the ovaries but limited to the pelvis (Stage II) were randomly assigned to treatment with either melphalan (in the same regimen as above) or a single intraperitoneal dose of 32P (15 mCi) at the time of surgery. In this trial (median follow-up, greater than 6 years) the outcomes for the two treatment groups were similar with respect to five-year disease-free survival (80 percent in both groups) and overall survival (81 percent with melphalan vs. 78 percent with 32P; P = 0.48). We conclude that in patients with localized ovarian cancer, comprehensive staging at the time of surgical resection can serve to identify those patients (as defined by the first trial) who can be followed without adjuvant chemotherapy. The remaining patients with localized ovarian cancer should receive adjuvant therapy, and with adjuvant melphalan or intraperitoneal 32P should have a five-year disease-free survival of about 80 percent.
Encapsulation of an 86-kDa Assembly Intermediate inside the Cavities of GroEL and Its Single-ring Variant SR1 by GroES (2003)

We described previously that during the assembly of the alpha(2)beta(2) heterotetramer of human mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD), chaperonins GroEL/GroES interact with the kinetically trapped heterodimeric (alphabeta) intermediate to facilitate conversion of the latter to the native BCKD heterotetramer. Here, we show that the 86-kDa heterodimeric intermediate possesses a native-like conformation as judged by its binding to a fluorescent probe 1-anilino-8-naphthalenesulfonate. This large heterodimeric intermediate is accommodated as an entity inside cavities of GroEL and its single-ring variant SR1 and is encapsulated by GroES as indicated by the resistance of the heterodimer to tryptic digestion. The SR1-alphabeta-GroES complex is isolated as a stable single species by gel filtration in the presence of Mg-ATP. In contrast, an unfolded BCKD fusion protein of similar size, which also resides in the GroEL or SR1 cavity, is too large to be capped by GroES. The cis-capping mechanism is consistent with the high level of BCKD activity recovered with the GroEL-alphabeta complex, GroES, and Mg-ATP. The 86-kDa native-like heterodimeric intermediate in the BCKD assembly pathway represents the largest protein substrate known to fit inside the GroEL cis cavity underneath GroES, which significantly exceeds the current size limit of 57 kDa established for unfolded proteins.
Small perturbations of chaotic dynamical systems (1989)

CONTENTS Introduction 1. Chaotic dynamical systems 1.1. A stochastic attractor. Hyperbolic systems. The method of symbolic dynamics 1.2. Dynamical systems with singularities. Piecewise stretching maps. The operator approach 1.3. The Li-Yorke chaos 2. Random perturbations of stochastic attractors 2.1. Random perturbations of hyperbolic systems 2.2. Random perturbations of systems with singularities 2.3. Stabilization of unstable invariant measures 2.4. The typical (generic) property and properties of e- and e-a-trajectories 2.5. The most probable trajectories 3. Space discretization in chaotic systems 3.1. Definitions and basic examples 3.2. Properties of the periodic trajectories under discretization 3.3. Statistical probability under discretizations 3.4. Stability of stochastic attractors under space discretizations 3.5. Chaos under a partial space discretization 4. Time discretization in dynamical systems 4.1. Chaos under time discretizations References
Luminescence of Europium(III) Chelates with 4‐(Arylethynyl)pyridines as Ligands (1993)

Abstract Some Spectral properties and luminescence intensities of Eu III chelates with 4‐(arylethynyl)pyridine‐2,6‐dicarboxylic acids 1 – 15 and 2,2′,2″,2′″‐{[4‐(arylethynyl)pyrridine‐2,6‐diyl]bis(methylenenitrilo)} tetrakis(acetic acids) 16 – 26 were measured both in H 2 O and EtOH solutions for the purpose of developing suitable labels to be used in time‐resolved luminescence‐based bioaffinity assays ( Tables 1 and 2 ). The substitution at the Ar group has a significant effect upon the observed luminescence intensities, excitation wavelengths, and decay constants of the complexes, Moreover, the changes in the environment cause great variation in those properties of certain Eu III chelates.