gebhart/patrepeval huggingface dataset:
<p>Anticandidal activity of biosynthesized silver nanoparticles: effect on growth, cell morphology, and key virulence attributes of Candida species</p> (2019)

<b>Purpose:</b> The pathogenicity in Candida spp was attributed by several virulence factors such as production of tissue damaging extracellular enzymes, germ tube formation, hyphal morphogenesis and establishment of drug resistant biofilm. The objective of present study was to investigate the effects of silver nanoparticles (AgNPs) on growth, cell morphology and key virulence attributes of Candida species. <b>Methods:</b> AgNPs were synthesized by the using seed extract of <i>Syzygium cumini</i> (Sc), and were characterized by UV-Vis spectrophotometer, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), and transmission electron microscopy (TEM). ScAgNPs were used to evaluate their antifungal and antibacterial activity as well as their potent inhibitory effects on germ tube and biofilm formation and extracellular enzymes viz. phospholipases, proteinases, lipases and hemolysin secreted by <i>Candida</i> spp. <b>Results:</b> The MICs values of ScAgNPs were ranged from 0.125-0.250 mg/ml, whereas the MBCs and MFCs were 0.250 and 0.500 mg/ml, respectively. ScAgNPs significantly inhibit the production of phospholipases by 82.2, 75.7, 78.7, 62.5, and 65.8%; proteinases by 82.0, 72.0, 77.5, 67.0, and 83.7%; lipase by 69.4, 58.8, 60.0, 42.9, and 65.0%; and hemolysin by 62.8, 69.7, 67.2, 73.1, and 70.2% in <i>C. albicans</i>, <i>C. tropicalis</i>, <i>C. dubliniensis</i>, <i>C. parapsilosis</i> and <i>C. krusei</i>, respectively, at 500 μg/ml. ScAgNPs inhibit germ tube formation in C. albicans up to 97.1% at 0.25 mg/ml. LIVE/DEAD staining results showed that ScAgNPs almost completely inhibit biofilm formation in C. albicans. TEM analysis shows that ScAgNPs not only anchored onto the cell surface but also penetrated and accumulated in the cytoplasm that causes severe damage to the cell wall and cytoplasmic membrane. <b>Conclusion:</b> To summarize, the biosynthesized ScAgNPs strongly suppressed the multiplication, germ tube and biofilm formation and most importantly secretion of hydrolytic enzymes (viz. phospholipases, proteinases, lipases and hemolysin) by Candia spp. The present research work open several avenues of further study, such as to explore the molecular mechanism of inhibition of germ tubes and biofilm formation and suppression of production of various hydrolytic enzymes by Candida spp.
Development of a 1.5 MW, Seven Level Series-stacked Converter as an APF and Regeneration Converter for a DC Traction Substation (2006)

A prototype 1.5 MW series-stacked converter system was built and installed at a DC-traction substation. The converter inverts energy generated by slowing an electric train using regenerative braking. The regenerated energy is fed into the local AC network at the DC-substation. A secondary function of the converter is to perform active power filtering (APF) while a train is drawing power from the substation. The systems control is based on the instantaneous reactive power theory. An interleaved switching scheme is used to switch the seven level series-stacked converter, thus exploiting the natural balancing properties of the series-stacked converter. Results obtained from tests done show that both the APF and regeneration functions of the system were successfully implemented
GaAsP/Si dual-junction solar cells grown by MBE and MOCVD (2015)

Monolithic, direct epitaxial GaAs <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.75</sub> P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.25</sub> /Si dual-junction (2J) solar cell structures have been grown via both molecular beam epitaxy (MBE) and metal-organic chemical vapor deposition (MOCVD). Fabricated test devices show working tandem behavior, with clear voltage addition and spectral partitioning, in both cases. Due to the thermal sensitivity of the MBE-grown tunnel junction structure, growth conditions necessary to maintain 2J activity yielded reduced quality GaAs <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.75</sub> P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.25</sub> top cell, while the more robust MOCVD-based tunnel junction enabled higher-quality top cell growth, resulting in overall higher performance 2J behavior. These initial prototype cells show promising performance and suggest several definite pathways for further device refinement.
On the mechanism of biotin synthase of Bacillus sphaericus. (1994)

A cell-free system of a bioB transformant of Bacillus sphaericus, effecting the last step of biotin biosynthesis, namely the introduction of sulfur into dethiobiotin has been recently described. S-adenosyl methionine (SAM) is absolutely necessary for activity. We show here, through experiments with [35S]SAM and [35S]Cys, that the sulfur donor is not SAM but probably cysteine (Cys) or a derivative. This finding together with the fact that NADPH and FAD are required for activity leads us to postulate some analogy between the biotin synthase system and other systems which use SAM as a source of desoxyadenosyl radical.
Learning Vector Quantization Neural Network Method for Network Intrusion Detection (2007)

基于学习，有低架空、高的效率的向量量子化(LVQ ) 被介绍的一个新侵入察觉方法。计算机视觉系统作为分类器采用 LVQ neuralnetworks 认出侵入。识别过程包括三个阶段：(1 ) 展示选择和数据正规化处理；(2 ) 学习训练数据选择了特征数据设置了的 fromthe；(3 ) 识别侵入并且产生 machinecondition 分类的结果报告。建议方法在为侵入察觉的术语 ofdetection 精确性，计算开销和实现是有希望的 Experimentalresults 表演。
On the Arithmetic of Abelina Functions (1927)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Protein-Ligand Interactions (2005)

A readily reproducible collection of established and emerging techniques for studying the interaction between proteins and ligands, including biochemical/bulk techniques, structure analysis, spectrosc
In vivo assessment of muscle mechanical properties using a low-cost surface wave method (2012)

Knowledge of muscle mechanical properties is important in clinical practice and biomechanical research. In usual clinical practice the muscle's Young modulus (Y) is qualitatively inferred through manual palpation and others valuation techniques of joint range. Although these methods are sensitive, they have predictable variations between different examiners, which reveals the need for methods capable of providing reliable quantitative values of muscular elasticity. Previous studies have shown that transient elastography (TE) is a useful method for assess locally and in vivo the Young modulus of muscle. In these works, experiments using TE were carried out on biceps brachii of healthy volunteers, testing the muscular elasticity changes under three load conditions: 0, 1 and 2 Kg. However, due to its high cost, this method is currently unavailable in many countries for standard clinical practice. In this work, taking into account the existing background with TE, we propose a low-cost method based on surface wave (SW) propagation for the in vivo assessment of the muscle's global mechanical properties. To validate the method, we repeated the experiments with TE, and compared the quantitative values and the general behavior exhibited by both methods. The results showed a good agreement between TE and SW methods, explaining the differences mainly by diffraction effects. We think that the in the current context, this method could be used widely in the rehabilitative and sports medicine field, both as a monitoring tool as well as research.
Pyroelectric Response of Triglycine Sulfate to Amplitude-Modulated X-Band Signals (1964)

The pyroelectric response of single-crystal triglycine sulfate to amplitude-modulated X-band microwave signals was obtained for a range of modulation frequencies, modulation coefficients, and microwave power levels. A first-order theory has been derived which corresponds reasonably well with the experimental results. Most of the departures of experiment from theory are qualitatively explicable in terms of second-order effects involving the increase in the average temperature of the TGS sample owing to the absorption of rf energy.
CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection (2001)

CD8 T cells are classified as naïve, effector, or memory cells on the basis of CD45RA, CD62L, and CCR7 expression. Sequential engagement of cell-surface CD62L and CCR7 receptors is required for efficient trafficking to lymphoid tissue by means of high endothelial venules. Naïve CD8 T cells are CCR7(+)CD62L(+) CD45RA(+), whereas long-term memory cells are CCR7(+)CD62L(+)CD45RA(-). Effector cytotoxic T cells are thought to be CCR7(-)CD45RA(+). The distribution of CD8 subsets and cytolytic protein expression in healthy donors and donors seropositive for human immunodeficiency virus (HIV) were compared. In HIV-infected subjects, CCR7(-) CD8 T cells expanded at the expense of naïve and long-term memory cells. In both healthy donors and HIV-infected donors, CCR7(+) CD8 T cells were uniformly negative for perforin. In all subsets, perforin and granzyme A were not coordinately expressed, with perforin expression being more tightly regulated. The properties of CD8 T cells specific for cytomegalovirus, Epstein-Barr virus (EBV), and HIV were studied by staining with major histocompatibility complex peptide tetramers. Antigen-specific cells for chronic infections with these viruses were uniformly CCR7(-) and predominantly CD62L(-). In 2 HIV-seropositive donors, 3- to 4-fold fewer EBV-tetramer-positive cells were present in lymph nodes compared with blood. Antigen-specific CD8 T cells are therefore preferentially excluded from lymphoid sites, even when infection is primarily in lymphoid tissue. This may protect lymphoid tissues from immunopathological changes but compromise immune defense against viruses, such as HIV and EBV, that target lymphocytes. HIV-specific CD8 T cells do not express CD45RA, whereas EBV- and CMV-specific CD8 T cells are heterogeneous in CD45RA(+) expression. Lack of CD45RA expression may indicate incomplete differentiation of HIV-specific CD8 T cells to cytotoxic T cells.
Effects of solvent mass transfer on flow of polymer solutions on a flat rotating disk (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of solvent mass transfer on flow of polymer solutions on a flat rotating diskSamson A. JenekheCite this: Ind. Eng. Chem. Fundamen. 1984, 23, 4, 425–432Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://pubs.acs.org/doi/10.1021/i100016a008https://doi.org/10.1021/i100016a008research-articleACS PublicationsRequest reuse permissionsArticle Views459Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Pancreatic secretion in man: effect of fasting, drugs, pancreatic enzymes, and somatostatin. (1994)

The inhibitory effect of different drugs on pancreatic secretions was assessed in a patient with a posttraumatic pancreatic-cutaneous fistula. The various drugs examined were: pancreatic enzymes, cimetidine, verapamil, propantheline, acetazolamide, and somatostatin analog octreotide. Only fasting and octreotide reduced pancreatic secretion. The optimum dose of octreotide was 50 micrograms bid given subcutaneously; increasing the dose up to 100 micrograms tid had no additional benefit. A stable pancreatic-cutaneous fistula is an excellent model to assess the effect of different therapeutic measures on pancreatic secretion.
Hepatocyte nuclear factor-4α reverses malignancy of hepatocellular carcinoma through regulating miR-134 in the DLK1-DIO3 region (2013)

Our data highlight the importance of the miR-379-656 cluster in the inhibitory effect of HNF4α on HCC, and suggest that regulation of the HNF4α-miRNA cascade may have beneficial effects in the treatment of HCC.
A Rapid One-Step Immunoradiometric Assay for Factor VIII-Procoagulant Antigen Utilizing Monoclonal Antibodies (1983)

A two-site immunoradiometric assay for factor VIII-procoagulant antigen (VIIICAg) that relies completely on monoclonal antibodies has been developed. By selecting an appropriate combination of these antibodies, it was possible to develop an assay in which the radiolabelled monoclonal antibody did not inhibit the binding of antigen to the solid-phase monoclonal antibodies. Thus, the entire test could be carried out as a one-step procedure. With this one-step assay, an amount of 0.0025 U VIIICAg/ml plasma could be detected after 4 hr of incubation, whereas 18 hr of incubation resulted in a lower limit of sensitivity of 0.0005 U VIIICAg/ml. The use of a one-step assay provides a significant advantage over the conventional two-step assay by simplifying, shortening and rendering the performance of the assay more convenient.
Oxynitride films formed by low energy NO+ implantation into silicon (1996)

Oxynitride (SiOxNy) insulators have been obtained by low-energy nitric oxide ion (NO+) implantation in Si substrates prior to thermal oxidation. Characterization by Fourier transform infrared (FTIR) and secondary ion mass spectrometry (SIMS) analyses reveal the presence of Si–O, Si–N, and Si–N–O bonds in the high quality 37 nm silicon oxynitride films. The dielectric constant=5.5, effective charge density=7×1010 cm−2 and breakdown E-fields of 3 MV/cm were determined by capacitance–voltage (C–V) and current–voltage (I–V) measurements, respectively, indicating that the SiOxNyfilms formed are suitable gate insulators for metal-oxide-semiconductor (MOS) devices.
Weaknesses and improvements of an efficient password based remote user authentication scheme using smart cards (2004)

Recently, Chien et al. proposed an efficient remote authentication scheme using smart cards. However, we find that their scheme is vulnerable to a reflection attack and an insider attack. In addition, their scheme lacks reparability. Herein, we first show the weaknesses of Chien et al.'s scheme, and then propose an improved scheme with better security strength.
Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. (1996)

The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic response to environmental contaminants such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. In an effort to gain insight into the physiological role of the AHR and to develop models useful in risk assessment, gene targeting was used to inactivate the murine Ahr gene by homologous recombination. Ahr-/- mice are viable and fertile but show a spectrum of hepatic defects that indicate a role for the AHR in normal liver growth and development. The Ahr-/- phenotype is most severe between 0-3 weeks of age and involves slowed early growth and hepatic defects, including reduced liver weight, transient microvesicular fatty metamorphosis, prolonged extramedullary hematopoiesis, and portal hypercellularity with thickening and fibrosis.
The physiological origin of task-evoked systemic artefacts in functional near infrared spectroscopy (2012)

A major methodological challenge of functional near-infrared spectroscopy (fNIRS) is its high sensitivity to haemodynamic fluctuations in the scalp. Superficial fluctuations contribute on the one hand to the physiological noise of fNIRS, impairing the signal-to-noise ratio, and may on the other hand be erroneously attributed to cerebral changes, leading to false positives in fNIRS experiments. Here we explore the localisation, time course and physiological origin of task-evoked superficial signals in fNIRS and present a method to separate them from cortical signals. We used complementary fNIRS, fMRI, MR-angiography and peripheral physiological measurements (blood pressure, heart rate, skin conductance and skin blood flow) to study activation in the frontal lobe during a continuous performance task. The General Linear Model (GLM) was applied to analyse the fNIRS data, which included an additional predictor to account for systemic changes in the skin. We found that skin blood volume strongly depends on the cognitive state and that sources of task-evoked systemic signals in fNIRS are co-localized with veins draining the scalp. Task-evoked superficial artefacts were mainly observed in concentration changes of oxygenated haemoglobin and could be effectively separated from cerebral signals by GLM analysis. Based on temporal correlation of fNIRS and fMRI signals with peripheral physiological measurements we conclude that the physiological origin of the systemic artefact is a task-evoked sympathetic arterial vasoconstriction followed by a decrease in venous volume. Since changes in sympathetic outflow accompany almost any cognitive and emotional process, we expect scalp vessel artefacts to be present in a wide range of fNIRS settings used in neurocognitive research. Therefore a careful separation of fNIRS signals originating from activated brain and from scalp is a necessary precondition for unbiased fNIRS brain activation maps.
Distributed computing: new power for scientific visualization (1996)

Distributed computing provides unique benefits for scientific visualization in this system (Discover) that supports interactive visualization and cooperative work for nonprogrammers. Discover (Distributed Interactive Scientific Computing and Visualization Environment), is suitable for many areas, but we have concentrated on medical image analysis and generation-one of the the most rapidly growing applications for scientific visualization. In its present form, Discover acts as a framework for clinical applications. True to its name, it allows a variety of users to discover the relevant information in a vast body of scientific data. Nonprogrammers, such as physicians and radiologists, interactively display and manipulate the two and three dimensional medical objects, visualize the results, control system computation, and generally drive the image analysis process. The emphasis is on the distributed nature of the software architecture and its functions. We also describe a unique load balancing algorithm designed to maximize workstation performance.
Mobile Information Systems In Australian Utility Companies (2009)

This research has investigated a broad range of issues associated with the use of mobile information systems in Australian utility companies. In particular, special consideration has been given to the existing infrastructure, business processes and information systems used in the participating organisations to support its field workers. This research has used a Technology, Organisation & People (TOP) multi-perspective model to conduct five case studies obtaining various technical, organisational and personal issues associated with the adoption of mobile information systems. These findings will help other large organisations to better manage their geographically distributed assets and workforce.
A rate-distortion approach to caching (2016)

In this paper, we consider a lossy single-user caching problem with correlated sources. We first describe the fundamental interplay between the source correlations, the capacity of the user’s cache, the user’s reconstruction distortion requirements, and the final delivery-phase (compression) rate. We then illustrate this interplay using a multivariate Gaussian source example and a binary symmetric source example. To fully explore the effect of the user’s distortion requirements, we formulate the caching problem using ${ {\mathsf {f}}}$ -separable distortion functions recently introduce by Shkel and Verdu. The class of ${ {\mathsf {f}}}$ -separable distortion functions includes separable distortion functions as a special case, and our analysis covers both the expected- and excess-distortion settings in detail. We also determine what “common information” should be placed in the cache, and what information should be transmitted during the delivery phase. To this end, two new common-information measures are introduced for caching, and their relationship to the common-information measures of Wyner, Gacs, and Korner is discussed in detail.
Effects of mask absorber thickness on printability in EUV lithography with high resolution resist (2008)

The effects of mask absorber thickness on printability in EUV lithography was studied from the viewpoint of lithographic requirements which can give high imaging contrast and reduce shadowing effect. From lithography simulation, optimum thickness range of mask absorber (LR-TaBN) for exposure latitude was predicted, and the effect of absorber thickness on MEF and H-V (Horizontal - Vertical) printed CD difference was determined using resist blur model. From printability experiments with a Small Field Exposure Tool (SFET) and with high resolution resist, optimum thickness of LR-TaBN absorber was demonstrated. When thinner absorber mask is employed in EUVL for ULSI chip production, it becomes necessary to introduce EUV light shield area in order to suppress the leakage of EUV light from neighboring exposure shots. Resist pattern CD change from the neighboring exposure shots was estimated by lithography simulation.
Catabolic enzymes of the acetogen Butyribacterium methylotrophicum grown on single-carbon substrates (1987)

When grown on formate, formate-CO, and methanol-CO, Butyribacterium methylotrophicum contained high levels of tetrahydrofolate (H4folate) and required enzymes, carbon monoxide dehydrogenase, formate dehydrogenase, and hydrogenase. The activities of methylene-H4folate reductase were comparable to other H4 folate activities (which ranged from 0.55 to 9.28 mumol/min per mg of protein) when measured by an improved procedure. The H4folate activities in formate-grown cells were twice those found in formate-CO-grown cells. This result correlated with a growth yield on formate that was one-half that on formate-CO. The stoichiometry of the formyl-H4folate synthetase reaction was 1 mol of ATP per 1 mol of formate. The methylene-H4folate dehydrogenase was NAD+ dependent. We conclude that B. methylotrophicum utilizes these enzymes in homoacetogenic catabolism.