gebhart/patrepeval huggingface dataset:
Packet/cell loss recovery using variable FEC matrix for real time transport services over best effort networks (2004)

Real-time services over best-effort networks, such as teleconferencing over unspecified bit rate (UBR) class asynchronous transfer mode (ATM) networks or the Internet, are expected to be in high demand in the near future as such services become more cost effective. However, cell loss caused by buffer overflow at switches is a serious problem in this service class, and is responsible for degradation of the quality of service (QoS). A promising technology for improving the QoS of best-effort networks is the recovery of lost cells by forward error correction (FEC). Conventional FEC methods utilize a FEC matrix with fixed dimensions and which is usually designed to cope with the worst case of cell loss. In this paper, a new method that provides dynamic recovery capacity to deal with the current cell loss ratio through the use of a variable-dimension FEC matrix is proposed. The scheme also takes into account the coding method of the matrix to provide data prioritization. Numerical results show that the cell loss ratio and transmission efficiency of the proposed method are superior to those of conventional methods.
Suggestion Mining: Detecting Suggestions for Improvement in Users' Comments (2013)

In the context of the development of a feature-based opi- nion mining system for English, we observed that there is some very interesting information provided by customers but not yet covered by \standard opinion mining techniques: opinion mining aims at detecting whether comments are positive or negative, but it appears that customers are very often suggesting improvements about what they are reviewing, which is quite dierent from expressing an opinion. This papers proposes to apply Natural Language Processing techniques in order to address this rather new task of extracting automatically such kind of suggestions for improvement from user's comments.
Implementation of a CKD Checklist for Primary Care Providers (2014)

Implementation of a CKD checklist significantly improved adherence to CKD management guidelines and delivery of CKD care.
A hierarchical structure for automatic meshing and adaptive FEM analysis (1987)

This paper deals initially with a new algorithm for generating automatically, from solid models of mechanical parts, finite element meshes that are organized as spatially addressable quaternary trees (for 2D work) or octal trees (for 3D work). Because such meshes are inherently hierarchical as well as spatially addressable, they permit efficient substructuring techniques to be used for both global analysis and incremental re‐meshing and re‐analysis. The paper summarizes the global and incremental techniques, and presents some results from an experimental closed loop 2D system in which meshing, analysis, error evaluation, and re‐meshing and re‐analysis are done automatically and adaptively. The paper concludes with a progress report on a 3D implementation.
A hardware-efficient, multirate, digital channelized receiver architecture (1998)

An approach is presented to realizing a digital channelized receiver for signal intercept applications that provides a hardware efficient implementation of a uniform filter bank in which the number of filters K is greater than the decimation factor M. The proposed architecture allows simple channel arbitration logic to be used and provides reliable instantaneous frequency measurements, even in adjacent channel crossover regions. In the proposed implementation of the filter bank, K is related to M by K=FM where F is an integer. It is shown that the optimum selection of F allows the instantaneous frequency measurement to be made in the channel crossover region and the arbitration function to be based solely on the instantaneous frequency measurement. The development of a filter bank structure which combines the flexibility of the short-time Fourier transform (STFT) with the implementation efficiency of the polyphase filter bank decomposition, meeting these requirements and leading to a hardware-efficient implementation, is presented.
Experiential Virtual Scenarios With Real-Time Monitoring (Interreality) for the Management of Psychological Stress: A Block Randomized Controlled Trial (2014)

ClinicalTrials.gov: NCT01683617; http://clinicaltrials.gov/show/NCT01683617 (Archived by WebCite at http://www.webcitation.org/6QnziHv3h).
Inhalable liposomes of<i>Glycyrrhiza glabra</i>extract for use in tuberculosis: formulation,<i>in vitro</i>characterization,<i>in vivo</i>lung deposition, and<i>in vivo</i>pharmacodynamic studies (2018)

LE LDPI thus has a promising potential to be explored as an effective anti-tubercular medicine or as an adjunct to existing anti-tubercular drugs.
[DNA topoisomerase inhibitor as chemotherapeutic drug--clinical point of view]. (1991)

CPT-11 is a semisynthesized derivative of camptothecin that has a potent antitumor activity by inhibiting DNA topoisomerase I. Leukopenia (mainly neutropenia) is DLF (dose limiting factor) and MTD (maximum tolerated dose) is higher than 250 mg/m2 in CPT-11 from the results of clinical phase I study. Now we are going on phase II study of CPT-11. We are seeing the cases responded to the drug in cancer of the lung, ovary, uterus, stomach, colorectum, pancreas, breast, malignant lymphoma etc.
DNA microarray for the identification of pathogens causing bloodstream infections (2010)

Rapid and accurate detection of life-threatening microbial pathogens with high morbidity and mortality is important for the treatment of suitable antibiotics to patients with infectious diseases. Recently, DNA microarray-based identification of pathogenic microorganisms has attracted much attention from clinical researchers owing to its efficiency, specificity and reproducible high-throughput capacities, compared with conventional culture-based diagnosis, which require a long period of time for cultivation and labor-intensive assay steps. In this article, we review recently published microarray-based diagnostic studies for accurate and rapid identification of pathogens infected in bloodstream and discuss the advantages and limitations over conventional diagnostic methods.
Improved noise reduction in audio signals using spectral resolution enhancement with time-domain signal extrapolation (2005)

In this paper, we present significant improvement to frame-by-frame noise reduction methods which are based on spectral domain processing. This work mainly focuses on the analysis stage of the noise reduction process. It is common knowledge that better performance is obtained by increasing the spectral resolution. However, effective spectral resolution depends directly on the number of samples in the processing frame. This leads to the well-known tradeoff between spectral and temporal resolution. Our approach is to use a novel discrete signal extrapolation method to prolong the given signal frame, resulting in increased spectral resolution without losing any temporal quality. The improvement in the noise reduction is tested with objective and subjective evaluations. The effect of the human auditory system is taken into account in the objective measures. Subjective tests are performed to determine the quality improvement in a perceptual sense.
Distributed MEMS transmission lines for tunable filter applications (2001)

This paper describes the design and fabrication of a distributed MEMS transmission line (DMTL), used to realize a transmission-line with a voltage-variable electrical length for microwave circuits. The DMTL is a coplanar waveguide periodically loaded with continuously-variable MEMS capacitors. A tunable bandpass filter was designed and fabricated on 700 μm thick glass substrates using three capacitively coupled DMTL sections as variable shunt resonators. The measured results demonstrate a 3.8% tuning range at 20 GHz with 3.6 dB minimum insertion loss. Issues for future improvement are discussed. © 2001 John Wiley & Sons, Inc. Int J RF and Microwave CAE 11: 254–260, 2001.
GHZ higher order contour mode ALN annular resonators (2007)

This work introduces a new class of low motional resistance piezoelectric aluminum nitride (AlN) MEMS ring resonators that operate in GHz contour modes of vibration. The resonators are based on an annular thin film AlN structural layer sandwiched between two or more pairs of concentric transduction electrodes whose design effectively uncouples the resonant frequency of the device from its transduction area (and consequently its motional resistance) at the layout level. The devices under test exhibit lithographically-defined fundamental series resonant frequencies from 1.03 to 1.60 GHz, motional resistances from 57 to 130 Omega, a resonator figure of merit (FOM = k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> Q) of 6.4 to 7.4, and no coherent spurious responses from DC to 5 GHz.
Distal Shift of Arterial Pressure Wave Reflection Sites With Aging (2010)

An early return of reflected waves, the backward propagation of the arterial pressure wave from the periphery to the heart, is associated with the augmentation of central pulse pressure and cardiovascular risks. The locations of arterial pressure wave reflection, along with arterial stiffening, have a major influence on the timing of the reflected wave. To determine the influence of aging on the location of a major reflection site, arterial length (via 3D artery tracing of MRI) and central (carotid-femoral) and peripheral (femoral-ankle) pulse wave velocities were measured in 208 adults varying in age. The major reflection site was detected by carotid-femoral pulse wave velocity and the reflected wave transit time (via carotid arterial pressure wave analysis). The length from the aortic valve to the major reflection site (eg, effective reflecting length) significantly increased with aging. The effective reflecting length normalized by the arterial length demonstrated that the major reflection sites were located between the aortic bifurcation and femoral site in most of the subjects. The normalized effective reflecting length did not alter with aging until 65 years of age and increased remarkably thereafter in men and women. The effective reflecting length was significantly and positively associated with the difference between central and peripheral pulse wave velocities (r=0.76). This correlation remained significant even when the influence of aortic pulse wave velocity was partial out (r=0.35). These results suggest that the major reflection site shifts distally with aging partly because of the closer matching of impedance provided by central and peripheral arterial stiffness.
Controlled release of BMP‐2 using a heparin‐conjugated carrier system reduces <i>in vivo</i> adipose tissue formation (2014)

There is growing concern about unwanted effects associated with the clinical use of recombinant human bone morphogenetic protein-2 (rhBMP-2) at high concentrations, including cyst-like bone formation and excessive fatty marrow formation. We, therefore, evaluated the induction of mineralized/adipose tissue formation and the bone-healing pattern associated with the controlled release of E. coli-derived rhBMP-2 (ErhBMP-2) by a heparin-conjugated fibrin (HCF) system using ectopic and orthotopic in vivo models, respectively. In the ectopic transplantation model, mineralized tissue formed at the most superficial layer of the transplanted area and on the surfaces of grafted materials, and most of the interstitial space within the transplanted area was filled with excessive adipose tissue specifically at sites that received ErhBMP-2. However, sites that received ErhBMP-2 and HCF showed significantly increased mineralized tissue formation and decreased adipose tissue formation compared to the normal fibrin system with ErhBMP-2. In the orthotopic (calvarial defect) model, controlled release of ErhBMP-2 induced by HCF significantly reduced adipose tissue formation within the defect area compared to the clinically approved absorbable collagen sponge. From these results, it can be concluded that the use of a HCF system loaded with ErhBMP-2 may reduce adipose tissue formation and enhance mineralized tissue formation.
The Land of No Strangers. Gwen Marsh. With illustrations by Jean Garside and music and songs by Bray Victoria de. (Geoffrey Cumberlege, Oxford University Press, 1951) 79 pp. 8s. 6d. (1953)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Interferon alpha treatment of relapsing–remitting multiple sclerosis: long-term study of the correlations between clinical and magnetic resonance imaging results and effects on the immune function (1995)

Interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) are proinflammatory cytokines which may be involved in the pathogenesis of MS. IFN-alpha counteracts many of the proinflammatory actions of IFN-gamma and TNF-alpha. We treated 20 patients with relapsing-remitting (RR) MS with 9 MIU of recombinant IFN-alpha-2a (rIFN-alpha) (n = 12) or placebo (n = 8) intramuscularly every other day for 6 months. Clinical exacerbations or new or enlarging lesions at serial MRI occurred in 2/12 rIFN-alpha-treated and in 7/8 placebo-treated patients (P < 0.005). Only one new MRI lesion was detected in the rIFN-alpha group, while 27 new or enlarging lesions were detected in placebo group (P < 0.01). Baseline lymphocyte IFN-gamma (19.10 +/- 7.12 U ml-1) and TNF-alpha (18.05 +/- 5.34 pg ml-1) production significantly decreased to 3.03 +/- 0.66 (P < 0.04) (for IFN-gamma) and to 5.78 +/- 0.90 (P < 0.04) (for TNF-alpha) after rIFN-alpha treatment. IFN-gamma and TNF-alpha production was unchanged in the placebo group. rIFN-alpha was tolerated without drop-outs or serious side-effects, but fever, malaise, fatigue (interfering with daily activities in two patients) and leukopenia frequently occurred. High-dose chronic systemic rIFN-alpha might reduce clinical and MRI signs of disease activity in RRMS. The changes in cytokine production suggest that the effect is probably mediated by a down-regulation of proinflammatory cytokine.
Hydroxide decomposition of dimethylsulfoniopropionate to form dimethylsulfide (1987)

The kinetics of DMS production resulting from reaction of OH − with DMSP were investigated as a function of hydroxide concentration and temperature. The reaction was first‐order with respect to DMSP and OH − . The second order rate constant at 20+/−1°C is 0.0044 M −1 sec −1 . The activation energy for this reaction is 14.4 kcal mole −1 . Our investigation indicates that the rate of reaction of DMSP with OH − is very slow at the pH of seawater (half‐life of about 8 years at 10°C), suggesting that DMSP, which may be a major precursor of DMS in seawater, decomposes in the ocean by other mechanisms. We have cultured a bacterium which produces DMS from DMSP quantitatively at rates many orders of magnitude higher than indicated by OH −1 decomposition, suggesting that enzymatic processes accelerate the production of DMS from DMSP in seawater.
Emerging roles of the microbiome in cancer (2013)

Gene-environment interactions underlie cancer susceptibility and progression. Yet, we still have limited knowledge of which environmental factors are important and how they function during tumorigenesis. In this respect, the microbial communities that inhabit our gastrointestinal tract and other body sites have been unappreciated until recently. However, our microbiota are environmental factors that we are exposed to continuously, and human microbiome studies have revealed significant differences in the relative abundance of certain microbes in cancer cases compared with controls. To characterize the function of microbiota in carcinogenesis, mouse models of cancer have been treated with antibiotics. They have also been maintained in a germfree state or have been colonized with specific bacteria in specialized (gnotobiotic) facilities. These studies demonstrate that microbiota can increase or decrease cancer susceptibility and progression by diverse mechanisms such as by modulating inflammation, influencing the genomic stability of host cells and producing metabolites that function as histone deacetylase inhibitors to epigenetically regulate host gene expression. One might consider microbiota as tractable environmental factors because they are highly quantifiable and relatively stable within an individual compared with our exposures to external agents. At the same time, however, diet can modulate the composition of microbial communities within our gut, and this supports the idea that probiotics and prebiotics can be effective chemoprevention strategies. The trajectory of where the current work is headed suggests that microbiota will continue to provide insight into the basic mechanisms of carcinogenesis and that microbiota will also become targets for therapeutic intervention.
TargetMiner: microRNA target prediction with systematic identification of tissue-specific negative examples (2009)

TargetMiner is now available as an online tool at www.isical.ac.in/ approximately bioinfo_miu
Design of a mixed 3.3 V and 5 V PCI I/O buffer (2002)

Design of a digital 3.3 V powered input/output buffer is presented in this paper. The new buffer, a true CMOS buffer, may work as a 3.3 V input buffer, 3.3 V output buffer, 5 V input buffer as well as 5 V output buffer in the PCI (Peripheral Component Interconnect) signaling environment. The concept of this design may also be used for other I/O and any circuit requiring mixing power and signaling environment.
Application of the Video Head Impulse Test to Detect Vertical Semicircular Canal Dysfunction (2013)

vHIT detects peripheral deficits of both vertical and horizontal semicircular canal function and is a new tool for measuring dysfunction of individual semicircular canals in vestibular patients.
Melatonin prevents the delayed death of hippocampal neurons induced by enhanced excitatory neurotransmission and the nitridergic pathway (1998)

The mechanisms by which neurons die after stroke and status epilepticus and related neuropathological conditions are unclear, but may involve voltage-dependent Na+ channels, glutamate receptors, and nitric oxide (NO.). These questions were investigated using an in vitro primary cell culture model in which hippocampal pyramidal neurons undergo a gradual and delayed neurodegeneration induced by enhanced excitatory neurotransmission. When cells were treated with Mg2+-free, glycine-supplemented medium for a brief period (15 min) and examined 24 h later, approximately 30-40% of the neurons had died. Cell death could be inhibited by blockers of voltage-sensitive Na+ channels and by N-methyl-D-aspartate receptor antagonists. Application of either the endogenous antioxidant melatonin (EC50: 19.2+/-2.8 microM) or the NO. synthase inhibitor Nomega-nitro-L-arginine after, but not during, Mg2+-free exposure protected against delayed neuronal death; significant neuroprotection was observed when the addition was delayed for up to 4 h. This operational time window suggests that an enduring production of NO. and reactive oxygen species from neuronal sources is responsible for delayed cell death. A role for reactive oxygen species in this injury process was strengthened by the finding that, whereas neurons cocultured with astroglia were more resistant to killing, agents capable of lowering intracellular glutathione negated this protection. Because secretion levels of melatonin are decreased with aging, reductions in this pineal hormone may place neurons at a heightened risk for damage by excitatory synaptic transmission.
Stress-Relief Simulation (2010)

Abstract This article summarizes many approaches that are used to simulate relaxation of bulk residual stresses in components. It presents analytical examples to highlight the complexity of residual stress and strain distributions observed in simple geometries, with ideal material behavior and trivial loading and boundary conditions. The article discusses approximate and advanced solution techniques that can be employed in practice for simulation of residual stress relief: finite-difference method and finite-element method. It also describes advanced techniques applicable to transient creep, advanced constitutive models, and complicated stress and temperature loading histories.
Rotating Waves as a Stall Inception Indication in Axial Compressors (1990)

Stall inception has been studied in two low speed compressors (a single-stage and a three-stage) and in a high speed three-stage compressor, using temporally and spatially resolved measurements. In all three machines, rotating stall was preceded by a period in which small amplitude waves were observed travelling around the circumference of the machine at a speed slightly less than the fully developed rotating stall cell speed. The waves evolved smoothly into rotating stall without sharp changes in phase or amplitude, implying that, in the machines tested, the prestall waves and the fully developed rotating stall are two stages of the same phenomenon. The growth rate of these disturbances was in accord with that predicted by current analytical models. The prestall waves were observed both with uniform and with distorted inflow, but were most readily discerned with uniform inflow. Engineering uses and limitations of these waves are discussed.
Direct shipping logistic planning for a hub‐and‐spoke network with given discrete intershipment times (2006)

Abstract This paper proposes a heuristic procedure to solve the problem of scheduling and routing shipments in a hybrid hub‐and‐spoke network, when a given set of feasible discrete intershipment times is given. The heuristic procedure may be used to assist in the cooperative operational planning of a physical goods network between shippers and logistics service provider, or to assist shippers in making logistics outsourcing decisions. The objective is to minimise the transportation and inventory holding costs. It is shown through a set of problem instances that this heuristic procedure provides better solutions than existing economic order quantity‐based approaches. Computational results are presented and discussed.
Advanced interfaces for teleoperated biomedical robots (2003)

General considerations are presented for the use of advanced interfaces for teleoperating robots capable of performing medical/surgical procedures. The authors point out that the design of a device that could allow the surgeon to command robot motion and force and to receive from the robot the sensory information about the external environment is strictly related to: (1) the availability of a sensorized dexterous end-effector as a slave device; (2) the ability of the master operator to control the robotic end-effector in the most natural way, i.e. by performing the same movements required in a real situation; and (3) the availability, on the master device, of components able to recreate for the human operator the sensory information acquired by the remote sensory systems. An instrumented glove able to transmit to the human operator kinesthetic force feedback and tactile feedback is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>