gebhart/patrepeval huggingface dataset:
Generic hierarchical engine for mask data preparation (2002)

Electronic layouts are usually flattened on their path from the hierarchical source downstream to the wafer. Mask data preparation has certainly been identified as a severe bottleneck since long. Data volumes are not only doubling every year along the ITRS roadmap. With the advent of optical proximity correction and phase-shifting masks data volumes are escalating up to non-manageable heights. Hierarchical treatment is one of the most powerful means to keep memory and CPU consumption in reasonable ranges. Only recently, however, has this technique acquired more public attention. Mask data preparation is the most critical area calling for a sound infrastructure to reduce the handling problem. Gaining more and more attention though, are other applications such as large area simulation and manufacturing rule checking (MRC). They all would profit from a generic engine capable to efficiently treat hierarchical data. In this paper we will present a generic engine for hierarchical treatment which solves the major problem, steady transitions along cell borders. Several alternatives exist how to walk through the hierarchy tree. They have, to date, not been thoroughly investigated. One is a bottom-up attempt to treat cells starting with the most elementary cells. The other one is a top-down approach which lends itself to creating a new hierarchy tree. In addition, since the variety, degree of hierarchy and quality of layouts extends over a wide range a generic engine has to take intelligent decisions when exploding the hierarchy tree. Several applications will be shown, in particular how far the limits can be pushed with the current hierarchical engine.
Investigation of switched-capacitorized DC/DC converters (2009)

Switched capacitor DC/DC converters are new prototype of DC/DC Conversion technology. Since switched capacitor can be integrated into a power IC chip, consequently, these converters have small size and high power density. Switched capacitor can be used in voltage-lift technique to construct DC/DC converters. The clue is that for the converters operating in discontinuous input current mode (DICM) the switched capacitors can be charged during the input current discontinuous period. The switched capacitors are charged to the source voltage during the switch-off period. They will join the conversion operation during switch-on period, and the stored energy in them will be delivered through further elements to the load. These converters are called switched-capacitorized DC/DC converters. Simulation and experimental results are provided for verification of this design.
Nicotine vaccines for smoking cessation (2012)

There is currently no evidence that nicotine vaccines enhance long-term smoking cessation. Rates of serious adverse events recorded in the two trials with full data available were low, and the majority of adverse events reported were at mild to moderate levels. The evidence available suggests nicotine vaccines do not induce compensatory smoking or affect withdrawal symptoms. No nicotine vaccines are currently licensed for use in any country but a number are under development.Further trials of nicotine vaccines are needed, comparing vaccines with placebo for smoking cessation. Further trials are also needed to explore the potential of nicotine vaccines to prevent relapse. Results from past, current and future research should be reported in full. Adverse events and serious adverse events should continue to be carefully monitored and thoroughly reported.
EFFECT OF TEMPERATURE ON THE DRYING PROCESS OF BEE POLLEN FROM TWO ZONES OF COLOMBIA (2011)

ABSTRACT The influence of the drying temperature (35 and 45C) on bee pollen is evaluated based on the physical, chemical and nutritional characteristics of dried bee pollen from two zones in Colombia (La Calera and Zipaquira). The methods used to establish the effect of the treatment are: determination of chemical composition, measurement of water activity, solubility index, mean particle size, vitamin C content and carotene content. The results confirm that the drying process of bee pollen at 45C has the shorter drying time (156–198 min), moisture content (7–8%) and water activity (0.3), but higher levels of carotene and vitamin C losses. The protein, fiber and ash contents are not affected by the drying temperature. The observed higher carotene content of the pollen from La Calera is probably because of the flora composition in this zone. The vitamin C content decreases as the drying temperature increases, but there are no significant differences between zones. PRACTICAL APPLICATIONS Bee pollen can be sold as both fresh and dried products. However, refrigeration with temperature between 5 and 10C is required for storage of the fresh bee pollen to preserve quality. The bee pollen drying allows preserving the product at room temperature, making the product marketing easier and increasing the profits of beekeepers. The drying process of bee pollen in Colombia is done by sun, solar and oven‐drying methods. But hot‐air drying is considered as a suitable drying method because it decreases drying time and improves the hygienic quality of the dried product. The chemical, physical and nutritional properties of dried bee pollen were studied in order to evaluate the effect of drying temperature on pollen from different origins. Thus, the results of this investigation can help the apiarists to use the best drying conditions to produce dried bee pollen.
<i>In Vivo</i> Augmentation of Natural Killer Activity by Combined Treatment with Recombinant Gamma Interferon and Interleukin-2 (1985)

The in vivo regulation of natural killer (NK) cell function by recombinant murine gamma interferon (rMuIFN-gamma) and recombinant human interleukin-2 (rHuIL-2) was investigated. Peritoneal exudate-derived natural killer (PE-NK) cells of mice treated with rMuIFN-gamma or rHuIL-2 exhibited significantly enhanced cytolytic activities against YAC-1 target cells. Compared with animals receiving treatment with either rMuIFN-gamma or rHuIL-2 alone, the sequential treatment of mice with both agents resulted in a significantly greater enhancement of PE-NK cell function, especially when rMuIFN-gamma was administered 24 h before treatment with rHuIL-2. The cytolytic activities were significantly diminished after pretreatment of effector cells with anti-Qa-5 antiserum and complement but not with anti-Lyt-3.2 antiserum. These data constitute the first evidence demonstrating the association between IFN-gamma and IL-2 in the regulation of NK cell function in vivo, reinforce the potential benefit of combined treatment with biological response modifiers, and show that the schedule of administration may be a critical requirement for optimal benefits of combined lymphokine treatment in vivo.
“In home” digital networks and cordless options (1997)

This paper examines the need and opportunity for in-home digital networks (IHDN) in general and why the interest they generate seems to be growing. The case for “cordlessness” is made and the likely strength of this capability is compared with, and related to, the expected performance of the latest wired options. A possible reconciliation is proposed between the apparently most competent bus oriented and connectionless wired contender and an emerging wireless technology based on ATM. The background for all this will be the perception that a significant, possibly the main, load on the in-home network will be offered by entertainment services. (6 pages)
Recombinant tobacco mosaic virus movement protein is an RNA-binding, α-helical membrane protein (2000)

The 30-kDa movement protein (MP) is essential for cell-cell spread of tobacco mosaic virus in planta. To explore the structural properties of MP, the full-length recombinant MP gene was expressed in Escherichia coli, and one-step purification from solubilized inclusion bodies was accomplished by using anion exchange chromatography. Soluble MP was maintained at >4 mg/ml without aggregation and displayed approximately 70% alpha-helical conformation in the presence of urea and SDS. A trypsin-resistant core domain of the MP had tightly folded tertiary structure, whereas 18 aa at the C terminus of the monomer were rapidly removed by trypsin. Two hydrophobic regions within the core were highly resistant to proteolysis. Based on results of CD spectroscopy, trypsin treatment, and MS, we propose a topological model in which MP has two putative alpha-helical transmembrane domains and a protease-sensitive carboxyl terminus.
Covering arrays for efficient fault characterization in complex configuration spaces (2004)

Testing systems with large configurations spaces that change often is a challenging problem. The cost and complexity of QA explodes because often there isn't just one system, but a multitude of related systems. Bugs may appear in certain configurations, but not in others.The Skoll system and process has been developed to test these types of systems through distributed, continuous quality assurance, leveraging user resources around-the-world, around-the-clock. It has been shown to be effective in automatically characterizing configurations in which failures manifest. The derived information helps developers quickly narrow down the cause of failures which then improves turn around time for fixes. However, this method does not scale well. It requires one to exhaustively test each configuration in the configuration space.In this paper we examine an alternative approach. The idea is to systematically sample the configuration space, test only the selected configurations, and conduct fault characterization on the resulting data. The sampling approach we use is based on calculating a mathematical object called a covering array. We empirically assess the effect of using covering array derived test schedules on the resulting fault characterizations and provide guidelines to practitioners for their use.
Synthesis of 5-Thio-D-Mannose (1989)

Abstract 5-Thio-D-mannose (1), the first 5-thiosugar found recently in nature, was synthesized in 12 steps from D-mannose.
Pentraxin 3: An Immuno-Regulator in the Lungs (2013)

Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that is a humoral component of the innate immune system. It interacts with pathogenic moieties, infected and dying host cells and facilitates their removal through activation of appropriate innate and adaptive mechanisms. PTX3 is secreted by a diverse variety of cells, ranging from immune cells to structural cells, in response to Toll like receptor (TLR) engagement, inflammatory stimuli, and physical and chemical stress. Further, PTX3 plays an essential role in female fertility as it facilitates the organization of extracellular matrix in the cumulus oophorus. Such activity is also implicated in post-inflammation tissue repair. PTX3 is a multifunctional protein and plays a non-redundant role in providing immunity against potential immunological dangers. Thus, we assessed its role in lung immunity, as lungs are at a constant risk of infections and tissue damage that is attributable to perpetual exposure to foreign agents.
Temperature-Controlled Reversible Localized Surface Plasmon Resonance Response of Polymer-Functionalized Gold Nanoprisms in the Solid State (2013)

Solid-state temperature responsive localized surface plasmon resonance (LSPR)-based nanosensors were constructed by functionalizing the glass substrate-attached gold nanoprisms with the thermoresponsive polymer poly(allylamine hydrochloride)-co-poly(N-isopropylacrylamide). The robustness of the sensor was enhanced by chemically attaching polymer to the nanoprism surface through an amide coupling reaction versus simple physisorption of polymer onto nanoprism. The highest sensitivity of this kind of solid sensing platform was obtained by employing chemically synthesized gold nanoprisms for fabrication. The surface ligand chemistry significantly influenced the swelling and shrinking transition of the polymer during the temperature variation, which resulted in the alteration of the local dielectric environment of the nanoprisms, modulation of their LSPR properties, and enhancement of sensing efficiency of the nanosensors. Importantly, we have shown for the first time that the dimension of the nanostructure plays an important role in achieving the highest sensitivity for these types of sensors. For example, the edge length of the nanoprisms plays a critical role in the temperature sensitivity of the nanosensors where nanoprisms with ∼28 and ∼40 nm edge lengths displayed ∼10.9 and ∼18.2 nm LSPR dipole peak red-shift, respectively, as the solution temperature increased from 18 to 56 °C. We believe the higher temperature sensitivity for larger edge-length nanoprisms was achieved due to their larger sensing volume. The nanosensors were found to be very stable and displayed high reversibility, which suggests that our temperature-dependent nanosensors can potentially be used as a reversible thermal switch.
Advanced pixel design for infrared 3D LADAR imaging (2008)

CEA Leti has demonstrated the good performances of its MWIR HgCdTe avalanche photodiode arrays. Gains above 20 at a moderate bias voltage of 5V have typically been measured with an excess noise factor of only 1.2. The next generation of infrared focal plane arrays will take advantage of these characteristics to address new applications, reduce system complexity and enhance performances. One of the main opportunities offered by avalanche photodiode detectors concerns long range active imaging. This paper reports the development of two novel pixel architectures for 3D active imaging based on flash LADAR technology. Both pixels have been designed in a standard 0.35μm CMOS process and perform time-of-flight measurement in addition to 2D intensity imaging with a single emitted laser pulse. The analog input circuits have been optimized to allow fast pulse detection while providing robustness to process variability. A small readout IC demonstrator has been fabricated and coupled to a 10x10 avalanche photodiode array at 40μm pixel pitch. The first test results in lab conditions show good electro-optical performances with a ranging resolution around 30cm (2ns).
A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia (2013)

Giardiasis is one of the most common causes of diarrheal disease worldwide. Treatment is primarily with 5-nitro antimicrobials, particularly metronidazole. Resistance to metronidazole has been described, and treatment failures can occur in up to 20% of cases, making development of alternative antigiardials an important goal. To this end, we have screened a chemical library of 746 approved human drugs and 164 additional bioactive compounds for activity against Giardia lamblia. We identified 56 compounds that caused significant inhibition of G. lamblia growth and attachment. Of these, 15 were previously reported to have antigiardial activity, 20 were bioactive but not approved for human use, and 21 were drugs approved for human use for other indications. One notable compound of the last group was the antirheumatic drug auranofin. Further testing revealed that auranofin was active in the low (4 to 6)-micromolar range against a range of divergent G. lamblia isolates representing both human-pathogenic assemblages A and B. Most importantly, auranofin was active against multiple metronidazole-resistant strains. Mechanistically, auranofin blocked the activity of giardial thioredoxin oxidoreductase, a critical enzyme involved in maintaining normal protein function and combating oxidative damage, suggesting that this inhibition contributes to the antigiardial activity. Furthermore, auranofin was efficacious in vivo, as it eradicated infection with different G. lamblia isolates in different rodent models. These results indicate that the approved human drug auranofin could be developed as a novel agent in the armamentarium of antigiardial drugs, particularly against metronidazole-resistant strains.
Estrogen Inhibition of PTH-Stimulated Osteoclast Formation and Attachment in Vitro: Involvement of Both PKA and PKC (2002)

Estrogens modulate the catabolic effects of PTH on bone in vivo and in vitro. PTH-stimulated cAMP accumulation in osteoblasts is thought to be linked to increased osteoclastic activity, but the precise mechanism is still unknown. In cocultures of clonal marrow stromal cells (MS1) and normal mouse spleen cells, both 1,25-dihydroxyvitamin D3 and rat PTH (rPTH)-(1–34) can induce the formation of tartrate-resistant acid phosphatase- and calcitonin receptor-positive multinucleated osteoclast-like cells, which can attach to dentine slices and produce resorption pits. In this system, osteoclastogenesis stimulated by PTH, but not by 1,25-dihydroxyvitamin D3, was suppressed by 17β-E2 (10−10–10−8m), whereas 17α-E2 (10−8m) had no effect. Exposure to 10−8m 17β-E2, but not 17α-E2, also significantly decreased the PTH-induced attachment of osteoclast-like cells to dentine slices. 17β-E2 inhibited osteoclast-like cell formation induced by 8-bromo-cAMP (10−4m), 12-O-tetradecanoylphorbol 13-acetate (10−8m), or rat PTH-(1–34) (10−7m) in combination with either rp-adenosine-3′,5′-cyclic monophosphorothioate (10−4m) or 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (10−5m). 17β-E2 suppressed the partial stimulation of tartrate-resistant acid phosphatase-positive multinucleated osteoclast-like cell formation induced by [Arg2]human (h) PTH-(1–34) (10−7m) or hPTH-(3–34) (10−7m), but not that caused by 10−7m hPTH-(53–84). We conclude that estrogens suppress PTH-stimulated osteoclast-like cell formation by blocking both the cAMP-dependent PKA pathway and the PLC-coupled calcium/PKC pathway. In addition to inhibiting formation of osteoclasts and promoting their apoptosis, estrogen may regulate bone resorption by blocking attachment of osteoclasts to bone.
A New Geraniol Chemotype of<i>Ocimum gratissimum</i>L. (1992)

ABSTRACT The essential oils which were obtained from the leaves, flowers and stems of Ocimum gratissimum in concentrations of 1.34%, 1.49% and 0.14% respectively, were examined by GC/MS. Fifteen constituents in the essential oil were identified with geraniol (83.7–88.8%) as the major constituent. Other major components included γ-muurolene (1.58–3.88%), β-caryophyllene (1.2–2.29%), neral (1.35–3.82%) and limonene (0.74–1.91%). Essential oil composition was similar among plant parts. Eugenol and thymol reported as the major constituent of Nigerian and Indian oil could not be detected in this oil. This is the first report of a geraniol-rich essential oil from O. gratissimum.
Accurate Activity Recognition Using a Mobile Phone Regardless of Device Orientation and Location (2011)

This paper investigates two major issues in using a tri-axial accelerometer-embedded mobile phone for continuous activity monitoring, i.e. the difference in orientations and locations of the device. Two experiments with a total of ten test subjects performed six daily activities were conducted in this study: one with a device fixed on the waist in sixteen different orientations and another with three different device locations (i.e., shirt-pocket, trouser-pocket and waist) in two different device orientations. For handling with varying device orientations, a projection-based method for device coordinate system estimation has been proposed. Based on the dataset with sixteen different device orientations, the experimental results have illustrated that the proposed method is efficient for rectifying the acceleration signals into the same coordinate system, yielding significantly improved activity recognition accuracy. After signal transformation, the recognition results of signals acquired from different device locations are compared. The experimental results show that when the sensor is placed on different rigid body, different models are required for certain activities.
BBR 3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin. (2000)

Multinuclear platinum complexes represent a new class of anticancer agents, distinct in terms of DNA binding features and the profile of antitumor activity from their mononuclear counterparts, in particular cisplatin. Among complexes of this class, BBR 3464, a trinuclear platinum compound has been selected for preclinical development. In the present study, we describe the preclinical evaluation of BBR 3464 in a series of human tumor cell lines and tumor xenografts, with special emphasis on tumor types known to be resistant to cisplatin. In a panel of seven human tumor cell lines naturally resistant to cisplatin (three ovarian and four melanomas), BBR 3464 was extremely potent with IC50 values at least 20-fold lower than cisplatin. Against eight human tumor xenografts including four tumors refractory to cisplatin, BBR 3464 was confirmed to be very active with a tumor weight inhibition >80% in seven of them. The efficacy of BBR 3464 against cisplatin-resistant tumors was consistent with the ability of the drug to completely overcome resistance in three cell systems characterized by acquired resistance to cisplatin. Moreover, BBR 3464 caused a more prolonged effect than cisplatin, which was reflected by higher specific growth delay values. This prolonged effect is likely to be related to a more persistent perturbation of the cell cycle induced by BBR 3464 than by cisplatin, as shown in one ovarian tumor cell line. Finally, the profile of sensitivity to BBR 3464 within the 60-cell-lines screening panel of the National Cancer Institute, NIH (Bethesda, MD) differed from those of established drugs, thus supporting the hypothesis of a distinct mechanism of cytotoxic activity of BBR 3464. The novel trinuclear platinum complex, in light of its innovative antitumor activity profile, has the potential to become a useful clinical agent for the treatment of unresponsive tumors.
A multipurpose cordless phone for use in both private and public systems (1989)

The high cost of cellular phone purchase and service still prices them out of reach of many consumers. However, the marriage of cordless phone technology to radio pagers offers the promise of a low cost device with much of the functional capability of cellular phones at a fraction of the cost.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The hypocholesterolemic function of barley beta-glucans (1989)

Barley is a good source of dietary fiber. This article discusses clinical studies which measure the hypocholesterolemic effect of barley foods on humans