gebhart/patrepeval huggingface dataset:
Successful gene therapy of the Gunn rat by in vivo neonatal hepatic gene transfer using murine oncoretroviral vectors† (2005)

Crigler-Najjar type 1 disease (CN1) is a rare inherited metabolic disease characterized by complete absence of hepatic UDP-glucuronosyl transferase (UGT1), resulting in high levels of unconjugated bilirubin. CN1 is an attractive candidate disease for gene therapy. Here we show that in vivo neonatal hepatocyte transduction using recombinant oncoretroviral vectors results in long-term and complete phenotype correction in Gunn rats, a model for CN1. Two-day-old newborn Gunn rats were injected via the temporal vein with 200 microL UGT1 or control beta-galactosidase retroviral vectors. In UGT1-injected animals, bilirubinemia was normal at 6 weeks (3 micromol/L) and remained in the normal range (i.e., <10 micromol/L) for more than 34 weeks. In contrast, in beta-galactosidase-injected animals as well as in noninjected controls, bilirubinemia remained at a high level (i.e., >100 micromol/L) during the whole experimental follow-up. Large amounts of bilirubin monoglucuronides and diglucuronides were present in the bile of treated animals. Finally, polymerase chain reaction and reverse transcription polymerase chain reaction analysis as well as Western blot confirmed the presence and expression of UGT1 almost exclusively in the liver. The estimated proportion of transduced hepatocytes was in the range of 5% to 10%. In conclusion, complete and permanent correction of hyperbilirubinemia in newborn Gunn rats using retroviral vectors can be obtained, paving the way for future gene therapy for CN1.
Computer assisted surgery: the use of digital images in enabling computerized design and manufacture of titanium implants (2002)

Computer assisted surgery often involves the use of medical images prior to surgery for the design of surgical implants such as titanium implants for facial and cranial reconstruction. The accurate design of these implants to produce a good functional and aesthetic result was very difficult, and the surgical insertion protracted by the need to make considerable adjustments to the implant at surgery for it to conform to the patient's anatomy. The advent of digital imaging in the form of CT, and the increasing accessibility of the digital data has led to the development of computer based systems for implant design. Computer assisted surgery has been extended into the use of such images as part of the surgical procedure, for example in the form of image guided surgery.
Automated, computer-guided PASI measurements by digital image analysis versus conventional physicians’ PASI calculations: study protocol for a comparative, single-centre, observational study (2018)

DRKS00011818; Results.
Saccharomyces cerevisiae Fungemia: An Emerging Infectious Disease (2005)

Use of S. cerevisiae probiotics should be carefully reassessed, particularly in immunosuppressed or critically ill patients.
Food and nutrition in the Caribbean : the implications for national and regional economic policy (1978)

The paper is divided into four parts. Part one presents some general views on the relationship between nutrition and economic development. Part two briefly outlines the methodological approach utilized. In part three some characteristics of food consumption and nutritional needs are discussed. Part four contains a discussion of some ramification on the supply side. This final section also deals with the policy implications of resource expansion and reallocation for meeting food needs.
Mechanical testing of cryopreserved aortic allografts. Comparison with xenografts and fresh tissue. (1990)

Reports indicate that cryopreserved aortic valve allografts have a better long-term survivability than other bioprostheses, such as the porcine xenograft. Unlike xenografts, allograft valves do not require treatment with glutaraldehyde and may therefore retain much of their original mechanical function. The effects of cryopreservation on the mechanical integrity of collagen fibers and mucopolysaccharides, however, are still largely unknown. We therefore compared the mechanical behavior of cryopreserved allograft leaflet material to that of fresh tissue and xenografts by measuring their bending stiffness (nine strips of tissue) and their uniaxial tensile stress/strain and stress/relaxation behavior (six strips of each tissue type). The bending tests showed no significant difference between the pliability of cryopreserved allografts and fresh pig aortic valve tissue, but the xenograft material was significantly stiffer than both (p less than 0.001). The mean circumferential tensile elastic moduli of the allografts, fresh tissue, and xenografts at a stress of 300 kPa were 9.1 +/- 5.4 MPa, 13.0 +/- 1.7 MPa, and 12.5 +/- 3.0 MPa, respectively, and were not significantly different from each other. We also found that the transition from a low to a high modulus on the stress/strain curves, a measure of extensibility, occurs at 23%, 22%, and 12% strain for the three materials. There was no significant difference between the allograft and the fresh tissues, but the xenograft material was less extensible than the other two (p less than 0.001). The xenograft tissue also had significantly lower rates of stress relaxation than the other two materials (p less than 0.005). Thus no detectable differences were found between the mechanical behavior of the cryopreserved allograft aortic leaflets and fresh tissue, whereas the xenograft material was less extensible and less capable of relaxing than both the allograft and fresh tissue. The ability of allografts valves to respond to tensile and flexural stresses in a manner similar to that of the natural aortic valve may therefore contribute to their good in vivo survivability.
Senecio Alkaloids: The Isolation of Senecionine from <i>Senecio Cineraria</i> and Some Observations on the Structure of Senecionine (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSenecio Alkaloids: The Isolation of Senecionine from Senecio Cineraria and Some Observations on the Structure of SenecionineRoger. Adams and T. R. GovindachariCite this: J. Am. Chem. Soc. 1949, 71, 6, 1953–1956Publication Date (Print):June 1, 1949Publication History Published online1 May 2002Published inissue 1 June 1949https://pubs.acs.org/doi/10.1021/ja01174a014https://doi.org/10.1021/ja01174a014research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Polymer and Small Molecule Mixture for Organic Hole Transport Layers in Quantum Dot Light-Emitting Diodes (2013)

The performance of quantum dot light-emitting diodes (QD-LEDs) was investigated for different hole transport layers with small molecules and polymers: poly(4-butyl-phenyl-diphenyl-amine), poly-N-vinylcarbazole (PVK), N,N'-diphenyl-N,N'-bis(3-methylphenyl)-1,1'-diphenyl-4,4'-diamine, 4,4',4″-tris(N-carbazolyl)-triphenyl-amine (TCTA), and 4,4'-bis(carbazole-9-yl)biphenyl (CBP). The electroluminescence performance of QD-LEDs was considerably improved by adding small molecules (TCTA or CBP) having high hole mobilily to the polymer hole transport material (PVK). The maximal current efficiency of QD-LED-based PVK was improved by 27% upon addition of 20 wt % TCTA due to the hole injection improvement. The lower turn-on voltage, the higher current density, and the higher luminance were achieved by addition of TCTA. The maximal luminance of 40900 cd/m(2) and the highest current efficiency of 14.0 cd/A with the narrow full width at half-maximum (<35 nm) were achieved by the best hole transport layer.
Evaluation of remote backup algorithms for transaction-processing systems (1994)

A remote backup is a copy of a primary database maintained at a geographically separate location and is used to increase data availability. Remote backup systems are typically log-based and can be classified into 2-safe and 1-safe, depending on whether transactions commit at both sites simultaneously or first commit at the primary and are later propagated to the backup. We have built an experimental database system on which we evaluated the performance of the epoch and the dependency reconstruction algorithms, two 1-safe algorithms we have developed. We compared the 1-safe with the 2-safe approach under various conditions.
Localization of 9E3/CEF-4 in avian tissues: expression is absent in Rous sarcoma virus-induced tumors but is stimulated by injury. (1990)

The avian gene 9E3/CEF-4, a member of the superfamily of genes that includes KC and gro, is expressed abundantly in exponentially growing cultures of chick embryo fibroblasts (CEFs) and at high levels in CEFs transformed with Rous sarcoma virus (RSV). The product of this gene is a secreted protein that has homologies and structural similarities to inflammatory mediators. The function of 9E3 is obscure and its expression in vivo has not yet been investigated. We studied by in situ hybridization and RNA blots the pattern of 9E3 mRNA distribution in the wings of normal, wounded, and RSV-infected newly hatched chicks. We found that the message for 9E3 is high in specific tissues in normal wings; whereas connective tissue, tendon, and bone express the gene, muscle fibers, endothelium, epidermis, and bone marrow do not. The distribution coincides with that of interstitial collagen. Wounding results in marked elevation of the mRNA within the granulation tissue formed during healing and in adjacent tissues, especially those showing neovascularization. Similar elevation of mRNA occurs immediately adjacent to RSV tumors but, surprisingly, the tumor tissue itself shows no detectable levels of this message. Cells explanted from the tumors and grown in culture also show no expression of 9E3, in marked contrast to the very high level found in similarly cultured RSV-transformed CEFs. These results show that there are intrinsic differences between transformed embryonic cells in tissue culture and RSV target cells in the hatched chick. However, the expression of the gene in the periphery of tumors leaves open the possibility that 9E3 may still be involved in RSV carcinogenesis. The abundant expression of 9E3 in normal tissues indicates that the product of this gene plays a normal physiological role in tissues growing by cell division, perhaps as a growth regulator. The elevated expression of 9E3 in areas of neovascularization, makes it possible that the product of this gene could act as an angiogenic factor. Finally, expression in conjunction with high collagen levels and in wounded tissues may point to a role in wound response and/or repair, possibly via alteration of extracellular matrix.
MAC protocol for wireless ATM: contention free versus contention based transmission of reservation requests (2002)

In general, the users of wireless ATM terminals request the same functionality and quality of service as users of wired terminals. These user requirements can be transformed into the demand for building an ATM multiplexer around the air interface which is characterized by a radio channel inside the ATM layer. The main difference between this logical ATM multiplexer around the air interface and a normal ATM multiplexer is the distribution of the multiplexing function between wireless terminals and the base station. For the uplink this requires a frequent notification of the ATM cell scheduler in the base station about the status of the incoming queues inside the wireless terminals. This paper focuses on different transmission methods for transmitting capacity request messages (also designated as reservation request) over the uplink.
In Defense of the Oral Cavity: Structure, Biosynthesis, and Function of Salivary Mucins (1995)

The oral environment, like other mucosal surfaces of the body, is coated by a slimy, viscoelastic coat termed mucus. This adherent layer, consisting predom­ inately of salivary glycoproteins, proteins, and lipids, forms ajelly-like blanket that represents the perimeter defense of the tissue/environmental interface (77). The unique physicochemical and rheological properties of the mucus coat are contributed largely by the heavily O-glycosylated mucin-glycoproteins (mu­ cins). Salivary mucins are synthesized by the mucus acinar cells of the paired submandibular (SMG) and sublingual (SLG) glands, as well as minor salivary glands distributed throughout the palatal and buccal mucosa. Serous acinar cells, such as those found in the human or rat parotid glands, do not contribute to the production of salivary mucins. Much of our current understanding of salivary mucin function has been derived by inference. Various subjective and objective functional losses have been catalogued in persons who lack the ability to produce adequate levels of saliva (4). Relevant findings include (a) the sensation of oral dryness, partic­ ularly among those subjects with compromised mucus gland function (26); (b) difficulty with swallowing; and (c) an increased susceptibility to dental cavity (caries) formation and the appearance of opportunistic yeast infections (thrush mouth). These findings have led to a generalized view that saliva functions to (a) hydrate and lubricate the oral structures; (b) facilitate the oral phase of
Results of the time series prediction competition at the Santa Fe Institute (2002)

From August 1991 onward, a set of time series was made generally available at the Santa Fe Institute. Several prediction tasks were specified and advertised. The submissions received before the deadline when the true continuations were revealed are analyzed. One result is that connectionist networks, trained with error backpropagation, outperformed the other methods on all series. Among the architectures that performed best was a time delay neural network (also called finite impulse response network) and a recurrent network, designed to capture the multiple time scales present in currency exchange rates.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
#SAT-based vulnerability analysis of security components &#x2014; A case study (2012)

In this paper we describe a new approach to assess a circuit's vulnerability to fault attacks. This is achieved through analysis of the circuit's design specification, making use of modern SAT solving techniques. For each injectable fault, a corresponding SAT instance is generated. Every satisfying solution for such an instance is equivalent to a circuit state and an input assignment for which the fault affects the circuit's outputs such that the error is not detected by the embedded fault detection. The number of solutions is precisely calculated by a #SAT solver and can be translated into an exact vulnerability measure. We demonstrate the applicability of this method for design space exploration by giving detailed results for various implementations of a deterministic random bit generator.
Photodynamic Therapy Causes Cross-linking of Signal Transducer and Activator of Transcription Proteins and Attenuation of Interleukin-6 Cytokine Responsiveness in Epithelial Cells (2004)

Photodynamic therapy (PDT) is a local treatment of cancers. The principle of PDT is the production of reactive oxygen species, in particular singlet oxygen, by light activation of a photosensitizer introduced into the target cells. The direct photochemical and subsequent redox reactions can lead to cell death. This study sought to identify effects occurring during PDT and some of their consequences in surviving cells. Using epithelial cells in tissue culture and in tumors, several distinct PDT-mediated reactions were found, including global dephosphorylation of proteins, induced phosphorylation of a 71-kDa protein, initiation of cellular stress responses, structural modification and loss of epidermal growth factor receptor, and cross-linking of proteins. Specific covalent cross-linking of nonactivated signal transducer and activator of transcription (STAT)-3, and to a lesser extent of STAT1 and STAT4, correlated with PDT dose. Cross-linked STAT3 was primarily localized to the cytoplasm and failed to bind to DNA. The combination of STAT cross-linking and inactivation of receptor functions rendered PDT-treated cells refractory for at least 24 hours to interleukin-6 and oncostatin M, cytokines known to be elevated at site of tissue damage and inflammation. It is suggested that the loss of responsiveness to these inflammatory cytokines in the PDT-treated field assists tumor cells in evading the growth-suppressive activity of these mediators expected to be present at tissue sites after PDT.
High Performance OTA-R-C Continuous-Time Filters with Full CMOS Low Distortion Floating Resistors (1991)

Several techniques for the design of high performance fully-differential Continuous-Time Filters are introduced. The filter is based on OTA-Resistor-Capacitor (OTA-R-C) building blocks. A novel Common Mode FeedBack (CMFB) system for fully-differential amplifiers is proposed. The CMFB uses only 5 transistors and consumes in the order of 21% of the OTA power consumption. Alsof a low distortion floating resistor with low sensitivity to transistor mismatches is presented. This technique allows to control the ripple of the filter without sacrificing the filter dynamic range. Evenmore, both power consumption and silicon area are lower than OTA based resistors. The techniques are validated by the experimental results of a fourth order 100 kHz Low-Pass filter. The dynamic range of the filter is in the order of 66 dB for Total Harmonic Distortion (THD) ≪ -60 dB. The power consumption is only 1.9 mWattsf with supply voltages of ± 2.5 Volts. The chip has been fabricated in a 1.2 ?m single poly N-well process. The experimental and expected results are in very good agreement.
The Importance of Jerusalem among Abrahamic Faiths as a Tool for Inter-Faith Dialogue and Peace (2014)

The Abrahamic faiths also referred to as Abrahamic religions, consist of Judaism, Christianity and Islam. These religions commonly lay claim to the fact that they all originated from Abraham. They therefore contest that they are directly linked to Abraham. The earliest of the Abrahamic faiths is Judaism, closely followed by Christianity, while the most recent is Islam. The study attempts to examine the importance of the city of Jerusalem to the Abrahamic faiths. To a large extent they all claim some level of relationship with Jerusalem. It is the aim of this study to examine how their common relationship with Jerusalem can engender inter-faith dialogue and unity which stands out as one the major concerns in the world today. The study employed historical and sociological methodology in its investigation. It is recommended that the Abrahamic faiths should appreciate the fact that their relationship with Jerusalem should be explored as a formidable panacea for establishing unity and inter-faith dialogue. The city of Jerusalem should be seen as a symbol of unity rather than that of hatred, war and morbid enmity.
Water jet as a laser light pipe (1976)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation A. Kshatriya; Water jet as a laser light pipe. Am. J. Phys. 1 June 1976; 44 (6): 604. https://doi.org/10.1119/1.10400 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAmerican Association of Physics TeachersAmerican Journal of Physics Search Advanced Search |Citation Search
Concise Review: Production of Cultured Red Blood Cells from Stem Cells (2012)

In the Western world, the volunteer-based collection system covers most transfusion needs, but transient shortages regularly develop and blood supplies are vulnerable to potentially major disruptions. The production of cultured red blood cells from stem cells is slowly emerging as a potential alternative. The various cell sources, the niche applications most likely to reach the clinic first, and some of the remaining technical issues are reviewed here.
Spectroscopic Characterization of a DNA-Binding Domain, Zα, from the Editing Enzyme, dsRNA Adenosine Deaminase:  Evidence for Left-Handed Z-DNA in the Zα−DNA Complex (1998)

Double-stranded RNA adenosine deaminase (ADAR1) is an ubiquitous enzyme in metazoa that edits pre-mRNA changing adenosine to inosine in regions of double-stranded RNA. Zalpha, an N-terminal domain of human ADAR1 encompassing 76 amino acid residues, shows apparent specificity for the left-handed Z-DNA conformation adopted by alternating (dGdC) polymers modified by bromination or methylation, as well as for (dGdC)13 inserts present in supercoiled plasmids. Here, a combination of circular dichroism, fluorescence, and gel-retardation studies is utilized to characterize recombinant Zalpha peptide and to examine its interaction with DNA. Results from laser-Raman spectroscopy experiments provide direct evidence for the existence of Z-DNA in peptide-DNA complexes.
The EM Algorithm for Portfolio (2007)

Investors should analyse the histories when they construct the optimizing portfolio.The histories were different because each bond markets appeared in different periods of time Investors would get incompleting data.If the discare information from the time series to make both conger and shorter time period have the same length,they would lose some available data.In fact,the longer histories would tell us more useful information.This dissertation offers EM algorithm.
Derivatives of Imidazole-4-carboxamide as Substrates for Various DNA Polymerases (1997)

Abstract A series of nucleotide analogs bearing imidazole 4-carboxamides as bases were synthetized. The ability of Klenow fragment of pol I and HIV-1 reverse transcriptase to use these 5′-triphosphate derivatives as substrates in DNA elongation reactions was investigated.
<b>Preparation of Indoles from </b> <b><i>o</i></b> <b>-Alkynyltrifluoroacetanilides Through the Aminopalladation-Reductive Elimination Process</b> (2004)

The functionalized pyrrole nucleus contained in the indole system has been assembled via the palladium-catalyzed reaction of o-alkynyltrifluoroacetanilides with organic halides/triflates or allyl carbonates. In the presence of carbon monoxide, a three-component reaction can take place and indole derivatives incorporating a molecule of carbon monoxide have been obtained.
Morphological Effects of WR-2721 on the Rat Parotid Acinar Cell (1978)

The morphologic effects of WR-2721 were studied on the rat parotid acinar cell at 20 and 60 min after injection. Cell secretion seen as zymogen granule release was the most important event and was accompanied by vacuolar expansion of Golgi vacuoles. Some cellular damage occurred, but it is not clear whether the damage is due to toxicity of WR-2721 or the usual sequelae of secretion.