gebhart/patrepeval huggingface dataset:
The Photosensitized Decomposition of Peroxides<sup>1</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Photosensitized Decomposition of Peroxides1Cheves Walling and Morton J. GibianCite this: J. Am. Chem. Soc. 1965, 87, 15, 3413–3417Publication Date (Print):August 1, 1965Publication History Published online1 May 2002Published inissue 1 August 1965https://pubs.acs.org/doi/10.1021/ja01093a022https://doi.org/10.1021/ja01093a022research-articleACS PublicationsRequest reuse permissionsArticle Views328Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Monoclonal antibody against a 250,000-dalton glycoprotein of Epstein-Barr virus identifies a membrane antigen and a neutralizing antigen. (1980)

An antibody-secreting hybrid cell line was produced by fusion of mouse myeloma cells with splenocytes from mice immunized with virions of the B95-8 strain of Epstein-Barr Virus (EBV). The monoclonal IgG antibody was shown to have anti-EBV activity by the following criteria: (i) It reacted with the membranes and the cytoplasm of seven different EBV-producing lines, but with no nonproducing line. (ii) The individual cells identified by the murine antibody were shown to be the same cells identified by a human serum having anti-EBV activity. (iii) The antibody significantly reduced the infectivity of two independent strains of EBV (namely, P3HR1K and B95-8). The antigen being recognized was characterized by immunoprecipitations of radiolabeled EBV-producer cell lysates. A single glycoprotein with an estimated molecular weight of 250,000 was identified. It is concluded that neutralization of EBV can be achieved by an IgG-class monoclonal antibody directed against a single antigenic site on a 250,000-dalton glycoprotein, which is a constituent of the EBV virion.
DFGmodel: Predicting Protein Kinase Structures in Inactive States for Structure-Based Discovery of Type-II Inhibitors (2014)

Protein kinases exist in equilibrium of active and inactive states, in which the aspartate-phenylalanine-glycine motif in the catalytic domain undergoes conformational changes that are required for function. Drugs targeting protein kinases typically bind the primary ATP-binding site of an active state (type-I inhibitors) or utilize an allosteric pocket adjacent to the ATP-binding site in the inactive state (type-II inhibitors). Limited crystallographic data of protein kinases in the inactive state hampers the application of rational drug discovery methods for developing type-II inhibitors. Here, we present a computational approach to generate structural models of protein kinases in the inactive conformation. We first perform a comprehensive analysis of all protein kinase structures deposited in the Protein Data Bank. We then develop DFGmodel, a method that takes either a known structure of a kinase in the active conformation or a sequence of a kinase without a structure, to generate kinase models in the inactive conformation. Evaluation of DFGmodel's performance using various measures indicates that the inactive kinase models are accurate, exhibiting RMSD of 1.5 Å or lower. The kinase models also accurately distinguish type-II kinase inhibitors from likely nonbinders (AUC > 0.70), suggesting that they are useful for virtual screening. Finally, we demonstrate the applicability of our approach with three case studies. For example, the models are able to capture inhibitors with unintended off-target activity. Our computational approach provides a structural framework for chemical biologists to characterize kinases in the inactive state and to explore new chemical spaces with structure-based drug design.
Experimental Design of Photo-Fenton Reactions for the Treatment of Car Wash Wastewater Effluents by Response Surface Methodological Analysis (2014)

Establishing a treatment process for practical and economic disposal of car wash wastewater has become an urgent environmental concern. Photo-Fenton’s process as one of the advanced oxidation processes is a potentially useful oxidation process in treating such wastewater. Lab-scale experiments with UV source, coupled with Fenton’s reagent, showed that hydrocarbon oil is degradable through such a process. The feasibility of photo-Fenton’s process to treat wastewater from a car wash is investigated in the present study. A factorial design based on the response surface methodology was applied to optimize the photo-Fenton oxidation process conditions using chemical oxygen demand (COD) reduction as the target parameter to optimize. The reagent (Fe 2+ and H 2 O 2 concentration) and pH are used as the controlling factors to be optimized. Maximal COD reduction (91.7%) was achieved when wastewater samples were treated at pH 3.5 in the presence of hydrogen peroxide and iron in amounts of 403.9 and 48.4 mg/L, respectively.
Surrogate teleoperated vehicle (STV) (1991)

The design of the STV is described. The STV system consists of two parts: the remote platform (RP) and the mobility/RSTA Module (MOB/RSTA). The RP consists of the carrier base and the remote control electronics that provide an interface to all systems on the STV and the communication system. It is based on an off-the-shelf Polaris six-wheel-drive, Ackerman-steered all-terrain vehicle that can exceed 58 km/h. The current automatic drive train will be modified using a dual motor hybrid concept that incorporates an electric motor to provide slow speed mobility when an ultraquiet mode is required. All electronics are packed in waterproof enclosures that allow for easy changeout of electronic components for simple and rapid maintenance operations. The modular MOB/RSTA module consists of an elevating mast and a pan and tilt turret with a variety of sensors. The electronics for the control of all turret functions, including sensor interfaces, are totally self-contained within the turret.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Self-Healing in Modern Operating Systems (2004)

Driving the stretch of Route 101 that connects San Francisco to Menlo Park each day, billboard faces smilingly reassure me that all is well in computerdom in 2004. Networks and servers, they tell me, can self-defend, self-diagnose, self-heal, and even have enough computing power left over from all this introspection to perform their owner-assigned tasks.
Preliminary Design Optimization of Impingement Cooled Turbine Airfoils (2008)

Generally, the objective of the turbine cooling design process is to minimize the amount of cooling flow required to achieve component life goals, including creep rupture, low-cycle (thermal-mechanical) fatigue, and material oxidation. High-pressure turbine airfoils in particular are subject to large variations in external gas temperatures and heat transfer coefficients, and high aero-mechanical loads. The efficient distribution of internal and film cooling flows, the management of internal coolant temperatures, and the optimal arrangement of cooling features to control thermal gradients are major factors in controlling thermal stress. The objective of this paper is to describe a process for conceptual and preliminary turbine airfoil cooling design based on the assembly of primitive cooling elements to define an overall “realizable” 3D airfoil cooling structure. This approach allows the evaluation of multiple cooling configurations, and potentially an improved prediction of cooling flows, early in the design process. This conceptual design method can be used to quickly generate models for fabrication and testing in a rapid prototyping laboratory. The design process is outlined for the simplified case of impingement cooling in a prototypical airfoil shape to illustrate some of the key design parameters and procedures. A future paper will address improvements in automation and more complex geometries. The paper also presents predictions based on a parametric impingement cooling model for the local surface heat transfer coefficient distribution. The model is easily incorporated into the conceptual design method. It is particularly useful for determining axial and radial thermal gradients the airfoil wall induced by sparse impingement arrays, for which the use of average heat transfer coefficients give unsatisfactory results. The model was calibrated using data from past published literature and more recently obtained experimental data from the GE Global Research Center.
TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice (2006)

Collectively, the power of the colitis model induced by the adoptive transfer of CD4CD45RB T cells into nude mice is that one can investigate the roles of TH2-type cells and B cells in a regulatory T cell-depleted condition.
FPGA Implementation of High Performance LDPC Decoder Using Modified 2-Bit Min-Sum Algorithm (2010)

In this paper, a reduced complexity Low-Density Parity-Check (LDPC) decoder is designed and implemented on FPGA using a modified 2-bit Min-Sum algorithm. Simulation results reveal that the proposed decoder has improvement of 1.5 dB Eb/No at 10-5 bit error rate (BER) and requires fewer decoding iterations compared to original 2-bit Min-Sum algorithm. With a comparable BER performance to that of 3bit Min-Sum algorithm, the decoder implemented using modified 2-bit Min-Sum algorithm saves about 18% of FPGA slices and can achieve an average throughput of 10.2 Gbps at 4 dB Eb/No.
Platelet factor 4 selectively inhibits binding of TGF‐β<sub>1</sub> to the type I TGF‐β<sub>1</sub> receptor (1991)

A low molecular weight inhibitor of TGF-beta 1 binding was detected in partially purified human platelet extracts by using Hep 3B hepatoma cells in the binding assays. The inhibitory protein was purified to homogeneity and was identified as platelet factor 4 on the basis of its amino acid sequence. TGF-beta 1 binding to Hep 3B cells was almost completely inhibited by 100 nM concentrations of platelet factor 4, but TGF-beta 1 binding to NRK 49F fibroblasts was inhibited only slightly. Affinity cross-linking experiments revealed that these differences in the inhibition of TGF-beta 1 binding by platelet factor 4 were due to differences in the complements of TGF-beta 1 binding proteins present on these two cell types. In Hep 3B cells the majority of bound TGF-beta 1 was cross-linked to a complex which had an apparent molecular weight of 70 kDa. TGF-beta 1 binding to this protein was the most sensitive to inhibition by platelet factor 4. Based on its size and TGF-beta 1 binding properties, we believe this protein is the type I TGF-beta 1 receptor. Hep 3B cells also had a high-affinity TGF-beta 1 binding protein which appeared as an 80 kDa complex, and which we believe to be the type II TGF-beta 1 receptor. TGF-beta 1 binding to this protein was not inhibited by platelet factor 4. TGF-beta 1 was also cross-linked to complexes of higher molecular weights in Hep 3B cells, but it was not clear whether any of them represented the type III TGF-beta 1 receptor. In NRK 49F cells, the majority of bound TGF-beta 1 was cross-linked to a high molecular weight complex which probably represented the type III TGF-beta 1 receptor. NRK 49F cells also had type I TGF-beta 1 receptors and platelet factor 4 inhibited binding to these receptors in the NRK cells. Since the type I receptor contributed only a small percentage of total TGF-beta 1 binding, however, the overall effects of platelet factor 4 on TGF-beta 1 binding to NRK 49F cells were negligible. We were unable to demonstrate specific or saturable binding of platelet factor 4 to Hep 3B cells using either direct binding or affinity cross-linking assays. Thus, it is not clear whether platelet factor 4 inhibits TGF-beta 1 binding by competition for binding to the type I receptor. Modest concentrations of TGF-beta 1 reduced the adherence of Hep 3B cells to tissue culture dishes.(ABSTRACT TRUNCATED AT 400 WORDS)
Temporal Deontic Relevant Logic as the Logical Basis for Decision Making Based on Anticipatory Reasoning (2006)

Any anticipatory reasoning-reacting system needs a right fundamental logic system to provide a criterion of logical validity for reasoning as well as a formal representation and specification language. The fundamental logic should underlie truth-preserving and relevant reasoning in the sense of conditional, ampliative reasoning, paracomplete reasoning, paraconsistent reasoning, normative reasoning, and temporal reasoning. This paper proposes a new family of relevant logics, named "temporal deontic relevant logic," and shows that it is a hopeful candidate for the fundamental logic.
Primary isolation of Cryptococcus neoformans from pigeon excreta on three media. (1968)

Ninety-two pigeon fecal samples assayed for Cryptococcus neoformans on plates of Littman, Sabouraud's dextrose agar and thistle seed (Guizotia abyssinica) medium yielded 45, 27, and 19 isolates, respectively. The superiority of Littman medium was attributed to better suppression of bacterial and saprophytic fungal growth and to a distinct blue-grey color of C. neoformans which facilitated its colonial identification. Although saprophytic overgrowth was less frequent on thistle seed medium than on Sabouraud's dextrose agar, some strains of C. neoformans failed to produce brown pigmentation at an early date. Also, in areas of the plates where some rapidly growing saprophytes appeared, C. neoformans failed to assume the tan or brown color, possibly because the saprophytes had destroyed the pigment producing substance.
Generalized linear models and Capture-Recapture Method in a closed population: strengths and weaknesses (2013)

Capture-recapture methods are used by epidemiologists in order to estimate the size of hidden populations using incomplete and overlapping lists of cases. These models can be both continuous and discrete time and the particular population we want to obtain a quantitative evaluation can be assumed to be closed or open. Here we specifically consider discrete-time models for closed population. The problem was treated using Generalized Linear Models as they allow to treat simultaneously both forms of dependence between sources than observed heterogeneity due to covariates effects. Specifically, we analyzed the strengths and weaknesses of Multinomial Conditional Logistic Model and presented a comparison with a correspondent Bayesian approach. The estimates obtained on simulated and real data appear to be enough reliable.
<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>K</mml:mi></mml:math>-shell ionization of heavy atoms by 40-110-MeV<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>α</mml:mi></mml:math>particles (1977)

Using intrinsic Ge as x-ray detector, $K$-shell ionization cross sections have been determined for Ho, Tm, Lu, Ta, W, Pt, Au, Pb, and Bi under bombardment with 40-110-MeV $\ensuremath{\alpha}$ particles. The target-atom $K$-shell ionization cross sections are compared with the predictions of different models. The agreement is considerably improved when relativistic effects are taken into account. Intensity ratios have also been measured and found to agree with previous determinations. X-ray satellite emission, following nuclear rearrangements, was also observed and a calculation made in the case of Ho to relate nuclear reactions and $K$ x-ray production cross sections. Small peaks in the spectra of Au, Pb, and Bi have been tentatively attributed to double $J$-shell ionization, and hypersatellite energy is given for these atoms.
The morphology and mechanical properties of layer structured cellulose microfibril foams from ice-templating methods (2011)

Ice-templated (IT) cellulose microfibril porous foams with unique layer structure and controllable channels were successfully fabricated via unidirectional freezing methods. The cellulose microfibril foam prepared from 1.0 wt% suspension shows a cross-linked network structure. Increasing the content of the cellulose microfibril in the suspension up to 2.75 wt% led to a gradual transition from a crosslinked network structure to a lamellar channel structure. Increasing the concentration of microfibrils in the suspension up to 8.0 wt% caused an increase of the thickness of wall and bridge degree. The wavelength of IT channel structures could be controlled from 2.8 μm to 11.2 μm by changing the temperature gradient between the ice front and the cellulose microfibril suspension. The compressive stress of IT cellulose microfibril foams increases linearly from 30.7 KPa to 360.2 KPa with increasing concentrations of cellulose microfibril suspension from 2.0 wt% up to 8.0 wt%.
An Inositol 1,4,5-Triphosphate (IP3)-IP3 Receptor Pathway Is Required for Insulin-Stimulated Glucose Transporter 4 Translocation and Glucose Uptake in Cardiomyocytes (2010)

Intracellular calcium levels ([Ca2+]i) and glucose uptake are central to cardiomyocyte physiology, yet connections between them have not been studied. We investigated whether insulin regulates [Ca2+]i in cultured cardiomyocytes, the participating mechanisms, and their influence on glucose uptake via SLC2 family of facilitative glucose transporter 4 (GLUT4). Primary neonatal rat cardiomyocytes were preloaded with the Ca2+ fluorescent dye fluo3-acetoxymethyl ester compound (AM) and visualized by confocal microscopy. Ca2+ transport pathways were selectively targeted by chemical and molecular inhibition. Glucose uptake was assessed using [3H]2-deoxyglucose, and surface GLUT4 levels were quantified in nonpermeabilized cardiomyocytes transfected with GLUT4-myc-enhanced green fluorescent protein. Insulin elicited a fast, two-component, transient increase in [Ca2+]i. Nifedipine and ryanodine prevented only the first component. The second one was reduced by inositol-1,4,5-trisphosphate (IP3)-receptor-selective inhibitors (xestospongin C, 2 amino-ethoxydiphenylborate), by type 2 IP3 receptor knockdown via small interfering RNA or by transfected Gβγ peptidic inhibitor βARKct. Insulin-stimulated glucose uptake was prevented by bis(2-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid-AM, 2-amino-ethoxydiphenylborate, and βARK-ct but not by nifedipine or ryanodine. Similarly, insulin-dependent exofacial exposure of GLUT4-myc-enhanced green fluorescent protein was inhibited by bis(2-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid-AM and xestospongin C but not by nifedipine. Phosphatidylinositol 3-kinase and Akt were also required for the second phase of Ca2+ release and GLUT4 translocation. Transfected dominant-negative phosphatidylinositol 3-kinase γ inhibited the latter. In conclusion, in primary neonatal cardiomyocytes, insulin induces an important component of Ca2+ release via IP3 receptor. This component signals to glucose uptake via GLUT4, revealing a so-far unrealized contribution of IP3-sensitive Ca2+ stores to insulin action. This pathway may influence cardiac metabolism in conditions yet to be explored in adult myocardium.
PATHOGENICITY OF A POLIOMYELITIS‐LIKE DISEASE IN MONKEYS INFECTED ORALLY WITH ENTEROVIRUS 71: A MODEL FOR HUMAN INFECTION (1982)

Ten cynomolgus monkeys were given enterovirus 71 (E71) by mouth. Clinically, only one monkey showed weakness of the lower extremities. Histopathologically, vascular lesions of variable intensity, perivascular cuffing, degeneration and necrosis of the neurons and neuronophagia were observed in the CNS of 7 monkeys. E71 was recovered from the CNS and specific immunofluorescence was detected in the neurons and in associated macrophages in the CNS. Serum neutralizing antibody titres rose from 14 to 21 days. These monkeys are as susceptible to E71 infection by the oral route as by the subcutaneous route as previously shown, and its neuronal virulence was confirmed by its producing CNS lesions after oral infection. The orally infected monkey with E71 appears to provide an excellent model for infection by this agent in man.
BER performance of orthogonalizing matched filter (OMF) in mobile DS-CDMA systems (2002)

This paper proposes orthogonalizing matched filter (OMF) detection with RAKE and antenna diversity reception for mobile DS-CDMA systems. OMF is a blind interference canceller controlling its coefficients adaptively by minimizing the average output power under a constraint coefficient condition. The OMF scheme with RAKE reception includes matched filters which are orthogonal to the desired signal multipath components. The OMF scheme with antenna diversity reception utilizes the OMF with RAKE reception for each diversity branch. Computer simulation results of both reverse and forward links show the effectiveness of the schemes under multipath fast fading environments.
A Low Argon Flow Inductively Coupled Plasma Torch Utilizing a Flame-Atomic Absorption Spectrometry Nebulizer (1981)

A very important factor influencing the performance of an inductively coupled plasma-atomic emission spectrometer is the plasma torch, which has been the subject of considerable experimentation by many workers. Almost all plasma torches using argon as the plasma and cooling gases require total gas flows in the range of 15 to 20 liters min−1.
Addressing static and dynamic errors in unit element multibit DACs (2003)

Nonlinearity in multibit current-steering digital-to-analogue converters (DACs) originates from static mismatch and switching imperfections. Several techniques are presented to avoid this nonlinearity. When applied, the DACs are suitable for use in the feedback of continuous-time ΣΔ-converters.
Mycothiol Is Essential for Growth of<i>Mycobacterium tuberculosis</i>Erdman (2003)

Mycothiol (MSH) is the major low-molecular-mass thiol in mycobacteria and is associated with the protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics. The biosynthesis of MSH is a multistep process, with the enzymatic reaction designated MshC being the ligase step in MSH production. A targeted disruption of the native mshC gene in M. tuberculosis Erdman produced no viable clones possessing either a disrupted mshC gene or reduced levels of MSH. However, when a second copy of the mshC gene was incorporated into the chromosome prior to the targeted disruption, multiple clones having the native gene disrupted and the second copy of mshC intact were obtained. These clones produced normal levels of MSH. These results demonstrate that the mshC gene and, more generally, the production of MSH are essential for the growth of M. tuberculosis Erdman under laboratory conditions.