gebhart/patrepeval huggingface dataset:
A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14) (1991)

The translocation t(10;14)(q24;q11) is an acquired change seen in 4% to 7% of T-cell acute lymphoblastic leukemias (T-ALL). We previously demonstrated that the translocation juxtaposes the T-cell receptor (TCR) delta-chain gene in chromosome 14q11 with a novel region in chromosome 10q24 and is likely catalyzed by recombinases normally involved in the generation of immunoglobulin and TCR diversity. We now present the sequence of a gene on chromosome 10 that lies immediately telomeric of the breakpoints in nine new ALL patients with acquired rearrangements in 10q24. The gene is a novel human homeobox gene and is expressed in leukemic cells from ALL patients with rearrangements in a defined chromosome 10 breakpoint cluster region, but not in other adult tissues or cell lines. This new gene has been designated HOX11. Our results strongly support a role for homeobox genes in oncogenesis and may represent the first example of a human cancer in which deregulated expression of an unaltered homeobox gene is involved in tumorigenesis.
Thyroid Enlargement in Lake Erie Coho Salmon (1974)

Pennsylvania, New York, and Ohio introduced stocks of coho salmon, Oncorhynchus kisutch, into Lake Erie. Of 117 mature salmon examined during the 1972 spawning migration, 44% had grossly enlarged thyroids. Microscopic examination of the thyroids revealed marked hyperplasia. Local invasion was not considered evidence of neoplasia because of the diffuse nature of the normal fish thyroid. The presence of intravascular thyroid cells in one enlarged gland raised the possibility of superimposed carcinoma in some fish
A dense 45nm half-differential SRAM with lower minimum operating voltage (2011)

We present a 45 nm half-differential 6T SRAM (HD-SRAM) with differential write and single-ended read, enabling asymmetric sizing and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> selection. The HD-SRAM bitcell uses SRAM physical design rules to achieve the same area as a commercial differential 6T SRAM (D-SRAM). We record measurements from 80 32 kb SRAM arrays. HD-SRAM is 18% lower energy and 14% lower leakage than D-SRAM. It has a 72 mV-lower V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MIN</sub> , demonstrating higher stability.
Reduced expression of the transporter associated with antigen processing 1 molecule in malignant glioma cells, and its restoration by interferon-γ and -β (2006)

Malignant glioma cells may be less immunogenic due to low levels of TAP1 expression. Upregulated expression of TAP1 and MHC Class I molecules by IFN-gamma and -beta may enhance antigen presentation in malignant glioma cells.
Retrieval Method For An Image Database Based On Topological Structure (1990)

We are developing multimedia information systems, concerning images, figures, characters and numeric values. In this paper, we describe a similarity retrieval method, that retrieves images or figures similar to given key images or figures. In this retrieval method, the topological structure of the key and that of the stored data are utilized to determine the similarity. For this determination, a level of similarity is designated by a user. According to this level, various traits of the stored image contents are retrieved (for example, whether the orientation of each element is concerned with the similarity or not). This retrieval method was applied to a house plan database and to a piping and instrumentation diagram database.
Solid lipid based nanocarriers: An overview / Nanonosači na bazi čvrstih lipida: Pregled (2012)

In the era of nanoparticulate controlled and site specific drug delivery systems, use of solid lipids to produce first generation lipid nanoparticles, solid lipid nanoparticles (SLN), became a revolutionary approach in the early nineties. The present review is designed to provide an insight into how SLN are finding a niche as promising nanovectors and forms a sound basis to troubleshoot the existing problems associated with traditional systems. Herein, authors had tried to highlight the frontline aspects prominent to SLN. An updated list of lipids, advanced forms of SLN, methods of preparation, characterization parameters, and various routes of administration of SLN are explored in-depth. Stability, toxicity, stealthing, targeting efficiency and other prospectives of SLN are also discussed in detail. The present discussion embodies the potential of SLN, now being looked up by various research groups around the world for their utility in the core areas of pharmaceutical sciences, thereby urging pharmaceutical industries to foster their scale-up.
Sigma Receptors as Endoplasmic Reticulum Stress “Gatekeepers” and their Modulators as Emerging New Weapons in the Fight Against Cancer (2018)

Despite the interest aroused by sigma receptors (SRs) in the area of oncology, their role in tumor biology remains enigmatic. The predominant subcellular localization and main site of activity of SRs are the endoplasmic reticulum (ER). Current literature data, including recent findings on the sigma 2 receptor subtype (S2R) identity, suggest that SRs may play a role as ER stress gatekeepers. Although SR endogenous ligands are still unknown, a wide series of structurally unrelated compounds able to bind SRs have been identified. Currently, the identification of novel antiproliferative molecules acting via SR interaction is a challenging task for both academia and industry, as shown by the fact that novel anticancer drugs targeting SRs are in the preclinical-stage pipeline of pharmaceutical companies (i.e., Anavex Corp. and Accuronix). So far, no clinically available anticancer drugs targeting SRs are still available. The present review focuses literature advancements and provides a state-of-the-art overview of SRs, with emphasis on their involvement in cancer biology and on the role of SR modulators as anticancer agents. Findings from preclinical studies on novel anticancer drugs targeting SRs are presented in brief.
[Synthesis, physical-chemical properties and pharmacologically-oriented screening studies on budipine and related 4,4-diphenylpiperidines]. (1984)

1-Alkyl-4,4-diphenylpiperidines 5-23 are accessible in a simple manner and with attractive yields by regioselective reaction of piperidine derivatives like 1, 2, 3 or particularly 3-aroyl-4-aryl-4-hydroxypiperidines 4, which can be varied widely at the nitrogen atom, with benzene under Friedel-Crafts conditions. The physico-chemical parameters, which are important for the transport and the distribution of a drug in a living system, are discussed for the 1-tert-butyl derivative 13 (budipine) (pKa, partition coefficient P, saturation concentration Cs, surface activity, protein binding). Rapid absorption of this drug in man is indicated by the size of the permeability coefficient PM of the passive transport through artificial phospholipid collodium membranes as well as the invasion curves calculated from PM. According to pharmacological screening tests, most of the compounds of this class show marked antagonistic activity against experimentally generated pathological states in mice (tremorine and reserpine antagonism) which suggest their potential use in the therapy of Parkinson's disease. 13 has been selected for detailed investigations. Structure-activity analyses did not readily demonstrate the presence of a relationship between the type of alkyl substituent at the piperidine nitrogen atom and the pharmacological screening results obtained.
Dictionary-based program compression on TTAs: effects on area and power consumption (2006)

Program code size has become a critical design constraint of embedded systems. Large program codes result in large memories, which increase the size and cost of the chip. Poor code density is a problem especially in VLIW architectures, where a long instruction word is used to control the concurrently operating hardware resources. In addition, wide instructions increase the memory bandwidth, which may result in increased power consumption. Dictionary compression is one of the most often used compression methods to improve the code density due to its simplicity. In this paper, dictionary-based program compression is applied on transport triggered architecture, a customizable processor architecture that is particularly suitable for tailoring the hardware resources according to the requirements of the application. The effects on area and power consumption were measured. We observed that at best, the area of the instruction memory and the fetch and decode logic could be reduced by 87%, and power consumption by 80%, correspondingly.
An Optical Method For In-Line Glass Flow Control (1989)

Oxide reflow, employed in IC technology to planarize the dielectric layers, is a critical step in multilevel CMOS processes. We have studied the control of the oxide reflow profile using laser beam diffraction by a line grating printed in the oxide film. Using an experimental set-up to record the diffracted light we found that a relation exists between the line profile and the diffraction pattern. In order to obtain a better understanding we developed a theoretical description of the full phenomenon : we first modelized the glass reflow as a purely viscous flow using numerical simulations. The diffraction was then analysed using a theory based on Maxwell equations and the corresponding equations were discretized. A good fit between theory and experiment was found showing a significant and sensitive correlation between the line profile and the diffraction pattern evolutions. These results lead to a new non-destructive in-line glass flow control method.
a) Généralités. Théories. Lois psychologiques. Processus physiologiques. (1924)

Piéron Henri, B. P., R. , M. I. a) Généralités. Théories. Lois psychologiques. Processus physiologiques.. In: L'année psychologique. 1924 vol. 25. pp. 462-491.
Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer (2007)

We used high-resolution array analysis to discover a recurrent lung cancer amplicon located at 14q13.3. Low-level gain of this region was detected in 15% of lung cancer samples, and high-level amplification was detected in an additional 4% of samples. High-level focal amplification appears to be specific to lung cancers, because it was not detected in >500 samples of other tumor types. Mapping of the commonly amplified region revealed there are three genes in the core region, all of which encode transcription factors with either established lung developmental function (TTF1/NKX2-1, NKX2-8) or potential lung developmental function (PAX9). All three genes were overexpressed to varying degrees in amplified samples, although TTF1/NKX2-1 was not expressed in the squamous cancer subtype, consistent with previous reports. Remarkably, overexpression of any pairwise combination of these genes showed pronounced synergy in promoting the proliferation of immortalized human lung epithelial cells. Analysis of human lung cancer cell lines by both RNAi and ectopic overexpression further substantiates an oncogenic role for these transcription factors. These results, taken together with previous reports of oncogenic alterations of transcription factors involved in lung development (p63, CEBPA), suggest genetic alterations that directly interfere with transcriptional networks normally regulating lung development may be a more common feature of lung cancer than previously realized.
Distributed phase shifters using (Ba,Sr)TiO<sub>3</sub> thin films on sapphire and glass substrates (2001)

Abstract In this paper, we present distributed phase shifter results employing voltage tunable (Ba,Sr)TiO3 (BST) thin film capacitors deposited by RF magnetron sputtering. Both parallel-plate and interdigital structures are investigated for different application requirements. The parallel-plate capacitor based circuit on glass (Vycor) substrate has a continuous 0–180? phase shift at 30 GHz with an insertion loss of 4dB and return loss better than 12 dB. A similar K-band phase shifter on a sapphire substrate was also demonstrated with a 0–270? differential phase shift and an insertion loss of 6.1dB at 20 GHz. The circuit using interdigital BST capacitors on sapphire substrate shows a continuous 0–360? phase shift at 8.2 GHz with an insertion loss of only 4.9 dB. These results show the feasibility of using BST thin film technology in microwave and millimeter wave phase shifter applications.
Experimental characterization of phenanthrenequinone-doped poly(methyl methacrylate) photopolymer for volume holographic storage (2003)

We present an experimental study on the photopolymer poly- (methyl methacrylate) doped with phenathrenequinone molecules. Mate- rial characteristics for holographic data storage, including optical charac- teristics, scattering effect, relation between diffraction efficiency and number of holograms, and exposure schedule for multiple storage, are investigated. An experimental demonstration of multiple storage of digital data pages in a polymer cube is presented. © 2003 Society of Photo-Optical
Financial Innovations and Market Volatility. (1993)

List of Tables. List of Figures. Foreword. Author's Preface. Part I: Before the Storm: 1. Financial Innovation: The Past Twenty Years and the Next. 2. Liquidity and Market Structure. 3. Financial Innovations and Market Volatility. Part II: The Crash of 1987 and Its Aftermath: 4. Index Futures During the Crash of 1987. 5. The Crash of 1987 and the Crash of 1946. 6. The Crash of 1987: Bubble of Fundamental. 7. Equilibrium Relations Between Cash Markets and Futures Markets. Part III: Markets and Volatility: Policy Issues: 8. Strategies for Capital Market Structure and Regulation. 9. Margin Regulation and Stock Market Volatility. 10. Should Short-Term Trading be Taxed? 11. Index Arbitrage and Volatility. 12. The International Competitiveness of US Futures Exchanges. 13. Volatility, Episodic Volatility and Coordinated Circuit Breakers. Part IV: The Academic Field of Finance: 14. The Academic Field of Finance: Some Observations on Its History and Prospects. Index.
Radio Localization and Mapping With Reconfigurable Intelligent Surfaces: Challenges, Opportunities, and Research Directions (2020)

5G radio for millimeter-wave (mm-wave) and beyond5G concepts at 0.1-1 THz can exploit angle and delay measurements for localization through an increased bandwidth and large antenna arrays, but they are limited in terms of blockage caused by obstacles. Reconfigurable intelligent surfaces (RISs) are seen as a transformative technology that can control the physical propagation environment in which they are embedded by passively reflecting radio waves in preferred directions and actively sensing this environment in receive and transmit modes. While such RISs have mainly been intended for communication purposes, they can provide great benefits in terms of performance, energy consumption, and cost for localization and mapping. These benefits as well as associated challenges are the main topics of this article.
Salvinorin A Produces Cerebrovasodilation through Activation of Nitric Oxide Synthase, κ Receptor, and Adenosine Triphosphate–sensitive Potassium Channel (2011)

Salvinorin A dilates cerebral arteries via activation of nitric oxide synthase, adenosine triphosphate-sensitive potassium channel, and the κ opioid receptor.
Pentacene Appended to a TEMPO Stable Free Radical: The Effect of Magnetic Exchange Coupling on Photoexcited Pentacene (2014)

Understanding the fundamental spin dynamics of photoexcited pentacene derivatives is important in order to maximize their potential for optoelectronic applications. Herein, we report on the synthesis of two pentacene derivatives that are functionalized with the [(2,2,6,6-tetramethylpiperidin-1-yl)oxy] (TEMPO) stable free radical. The presence of TEMPO does not quench the pentacene singlet excited state, but does quench the photoexcited triplet excited state as a function of TEMPO-to-pentacene distance. Time-resolved electron paramagnetic resonance experiments confirm that triplet quenching is accompanied by electron spin polarization transfer from the pentacene excited state to the TEMPO doublet state in the weak coupling regime.
A new method for centrifugal separation of blood components: Creating a rigid barrier between density-stratified layers using a UV-curable thixotropic gel (2011)

Current gels used in blood separation tubes create an imperfect barrier between the blood components because of their physical and thixotropic nature. As a result, blood components tend to leak into the gel layer or vice versa during transport and storage. To overcome these problems, we demonstrate the use of a UV-curable thixotropic gel composed of a sorbitol-based gelator in a diacrylate oligomer. Initially, the sample is a physical gel composed of weak, non-covalent bonds, and its thixotropic nature allows it to flow under centrifugation and form a barrier between the density-stratified layers of blood. Immediately afterward, the gel is chemically crosslinked by short exposure to UV light for 10–30 s. This results in a rigid, impenetrable barrier that is freeze-thaw stable. The gel is compatible with blood, allowing blood samples to be stored in the tube and analyzed over long times. We believe the present method is a significant advance in the practice of blood analysis for medical purposes.
Analytics with smart arrays (2018)

This paper introduces smart arrays, an abstraction for providing adaptive and efficient language-independent data storage. Their smart functionalities include NUMA-aware data placement across sockets and bit compression. We show how our single C++ implementation can be used efficiently from both native C++ and compiled Java code. We experimentally evaluate smart arrays on a diverse set of C++ and Java analytics workloads. Further, we show how their smart functionalities affect performance and lead to differences in hardware resource demands on multicore machines, motivating the need for adaptivity. We observe that smart arrays can significantly decrease the memory space requirements of analytics workloads, and improve their performance by up to 4x. Smart arrays are the first step towards general smart collections with various smart functionalities that enable the consumption of hardware resources to be traded-off against one another.
[Oncocytic cyst of the larynx]. (1994)

Oncocytic cysts of the larynx are rare, clinically similar to simple laryngeal cysts and a chance find in pathology study. We report a case because of its uncommon localization and presentation and we expound different pathogenical theories.
Characteristics of lipase‐catalyzed hydrolysis of olive oil in AOT–isooctane reversed micelles (1986)

Candida rugosa lipase solubilized in organic solvents in the presence of both surfactant and water could catalyze the hydrolysis of triglycerides, and kinetic analysis of the lipase-catalyzed reaction was found to be possible in this system. Among eight organic solvents tested, isooctane was most effective for the hydrolysis of olive oil in reversed micelles. Temperature effect, pH profile, K(m,app) and V(max,app) were determined. Among various chemical compounds, Cu(2+), Hg(2+), and Fe(3+) inhibited lipase severely. But the enzyme activity was restorable partially by adding histidine or glycine to the system containing these metal ions. The enzyme activity was dependent on R (molar ratio of water to surfactant) and maximum activity was obtained at R = 10.5. Upon addition of glycerol to the reversed micelles, lipase activity was affected in a different fashion depending on the R values. Stability of the lipase in reversed micelles was also dependent on R, and it was most stable at R = 5.5.
[Quorum sensing involved in the regulation of secondary metabolism in streptomycetes--a review]. (2011)

Quorum sensing as an extracellular signal transduction system is distributed widely among many bacteria to coordinate their behaviors or actions by mediating gene expression, and plays key roles in many physiological processes and pathogenicity. Quorum sensing was also observed among many streptomycetes, as an important regulatory mechanism of secondary metabolite biosynthesis and/or cell differentiation, and displayed certain diversity of the autoinducer structures and action mechanisms. The participation of A-factor-driven quorum sensing systems in the secondary metabolism has been extensively studied, and triggered the identification of a major signal class featured with gamma-butyrolactone core. Additionally, PI-factor, M-factor and certain small antibiotic molecules recently found in streptomycetes clearly could play important roles in the biosynthetic pathways of some antibiotics, and might represent extracellular autoinducer classes with novel structures. Meanwhile, some specific products of streptomycetes including cholesterol oxidase and glycerol have been identified to function as cell-signaling molecules which modulate the secondary metabolic activities in streptomycetes, probably by the mode of quorum sensing. Here, we reviewed research advances on quorum sensing systems involved in the accumulation of secondary metabolites in streptomycetes, mainly focusing on the clarification of their action modes and structural diversity of autoinducers. We also prospected the research trends in this field and application of autoinducers through quorum-sensing in metabolic engineering of natural products.
Grammatical Theory - (1) R. H. Robins: Ancient and Mediaeval Grammatical Theory in Europe with particular reference to Modern Linguistic Doctrine. Pp. viii+104. London: Bell, 1951. Cloth, 8<i>s</i>. 6<i>d</i>. net. - (2)A. G. de Man: In Grammaticis Veritas. De noodzakelijke Vernieuwing van het Onderwijs in Latijn. Pp. iv+136. Groningen: J. B. Wolters, 1951. Paper, f. 3.90. (1953)

Grammatical Theory - (1) R. H. Robins: Ancient and Mediaeval Grammatical Theory in Europe with particular reference to Modern Linguistic Doctrine. Pp. viii+104. London: Bell, 1951. Cloth, 8s. 6d. net. - (2)A. G. de Man: In Grammaticis Veritas. De noodzakelijke Vernieuwing van het Onderwijs in Latijn. Pp. iv+136. Groningen: J. B. Wolters, 1951. Paper, f. 3.90. - Volume 3 Issue 1
A coarse-to-fine model for 3D pose estimation and sub-category recognition (2015)

Despite the fact that object detection, 3D pose estimation, and sub-category recognition are highly correlated tasks, they are usually addressed independently from each other because of the huge space of parameters. To jointly model all of these tasks, we propose a coarse-to-fine hierarchical representation, where each level of the hierarchy represents objects at a different level of granularity. The hierarchical representation prevents performance loss, which is often caused by the increase in the number of parameters (as we consider more tasks to model), and the joint modeling enables resolving ambiguities that exist in independent modeling of these tasks. We augment PASCAL3D+ [34] dataset with annotations for these tasks and show that our hierarchical model is effective in joint modeling of object detection, 3D pose estimation, and sub-category recognition.