gebhart/patrepeval huggingface dataset:
Morbidity of the neck after head and neck cancer therapy (2004)

Abstract Background. Studies on morbidity of the neck after head and neck cancer therapy are scarcely described. Methods. Patients who underwent surgery, including neck dissection, with and without radiation therapy at least 1 year before the study were asked to participate. We assessed neck pain, loss of sensation, range of motion of the cervical spine, and shoulder pain. Results. Of the 220 patients who were invited, 153 (70%) participated in the study. Neck pain was present in 33% of the patients ( n = 51), and shoulder pain was present in 37% of the patients ( n = 57). Neuropathic pain of the neck was present in 32% ( n = 49); myofascial pain, in 46% ( n = 70); and joint pain, in 24% ( n = 37). Loss of sensation of the neck was present in 65% ( n = 99) and was related to type of neck dissection and radiation therapy. Range of motion of the neck was significantly decreased because of the neck dissection and/or radiation therapy in lateral flexion away from the operated side. Conclusions. The occurrences of morbidity of the neck after cancer therapy were considerable and consisted of neck pain, loss of sensation, and decreased range of motion. © 2004 Wiley Periodicals, Inc. Head Neck 26: 785–791, 2004
A multi-resonant converter for non-contact charging with electromagnetic coupling (2002)

A parallel resonant power converter (PRC-LLCC) is analyzed for automatic inductive charging applications. The tank circuit of this power converter consists of a leakage inductance, a magnetizing inductance and two power capacitors with an inductive output filter. This converter allows the transfer of power without oversizing the inverter and a soft-switching mode of the transistors. The soft-switching mode and the sensitivity to the load variation, the coupling factor and the air gap (6-8 mm) are studied using the first harmonic method. The choice of the working range and the validity limit of the analysis method are presented. Theoretical results are validated experimentally with a 3 kW prototype.
Neuromuscular development and disease (1992)

Nautilus, a Drosophila member of the myogenic regulatory gene family myogenin and the control of muscle-specific gene expression functional properties associated with MRF4 and other members of the bHLH muscle regulatory factor family functional domains in the muscle-specific transcription factor Myf-5 myogenesis in the mouse - the expression of regulatory and structural genes comparative aspects of skeletal and cardiac muscle gene regulation regulation of Avian sarcomeric alpha-actin genes by myogenic helix-loop-helix regulatory factors, serum response factors, and F-ACT1 c-ski expression can increase the skeletal musculature of transgenic mice, a genetic approach to cloning regulators of mammalian differentiation the myosin light-chain 1/3 locus - a model for developmental control of skeletal muscle differentiation developmental regulation of the chicken alkali light-chain gene expression alternative RNA splicing in the control of gene expression in muscle and nonmuscle cells chicken fast myosin heavy chains multiple myogenic cell precursors and their possible role in muscle histogenesis positional differences among adult skeletal muscle fibres myofilament assembly in muscle development of Caenorhabditis elegans molecular genetic manipulation of cardiac myosin the role of innervation in the differentiation of early muscle fibre types in the rat regulation of molecules at the neuromuscular junction molecular basis of axonal growth - role of cell adhesion molecules clustering of acetylcholine receptors by extracellular synaptic factors the nature of mutation and the prospect for therapy in Duchenne muscular dystrophy the mdx mouse and mdx diaphragm - implications for the pathogenesis of Duchenne muscular dystrophy myoblast transfer into skeletal muscle - unresolved questions of new muscle formation from injected myogenic cells tissue and cell type distribution of transcripts of the Duchenne muscular dystrophy gene prospects for cell transplantation and gene therapy in inherited myopathies.
Distinct expression pattern of periostin splice variants in chondrocytes and ligament progenitor cells (2019)

Periostin (<i>POSTN</i>), a secretory matricellular matrix protein, plays a multitude of biologic functions. Various splice variants of <i>POSTN</i> have been described; however, their expression pattern and functional implications are not completely understood. This study was undertaken to decipher the differential expression pattern of <i>POSTN</i> and its splice variants in various tissues and cell types. We show that <i>POSTN</i> was more highly expressed in anterior cruciate ligament (ACL) remnants compared with articular cartilage at the cellular and tissue level. Isoforms 1 and 8 were highly expressed only in articular chondrocytes, suggesting their splice-specific regulation in chondrocytes. To discern the role of total <i>POSTN</i> and full-length human POSTN isoform 1 (<i>hPOSTN-001</i>), we stably transfected human chondrosarcoma 1 (hCh-1) cell line with <i>hPOSTN-001</i> using a pcDNA3.1-hPOSTN-001 construct. RNA-sequencing analysis of hCh-1 cells identified differentially expressed genes with a known role in chondrocyte function and osteoarthritis. Similar expression of a subset of candidate genes was revealed in ACL progenitor cells and chondrocytes as well as in ACL progenitor cells in which <i>POSTN</i> activity was altered by overexpression and by small interfering RNA gene knockdown. Cells expressing total <i>POSTN</i>, not isoform 1, exhibited increased cell adhesion potential. These findings suggest an important role for <i>POSTN</i> in the knee.-Cai, L., Brophy, R. H., Tycksen, E. D., Duan, X., Nunley, R. M., Rai, M. F. Distinct expression pattern of periostin splice variants in chondrocytes and ligament progenitor cells.
Layered representations for image coding (1991)

Introduction In order to represent a television image sequence with a minimal number of bits, it is necessary to perform efficient image coding. Transform coding, subband coding, and vector quantization are examples of popular techniques that have been applied to the coding of still and moving images. In the case of moving image sequences, these techniques are often combined with frame-differencing or motion compensation, to take advantage of the temporal structure of image sequences. Any image coding technique contains an implicit vocabulary and image model; that is, it offers a way to describe images. For example, in a discrete cosine transform technique, an image is described as a sum of cosine basis functions, and this forms the implicit image model. If motion compensation is used for moving images, then the implicit image model includes the idea that regions of the image move coherently across time. There are three interrelated parts to the design of an image coding syste
Mendelian Inheritance in Man. Catalogs of Autosomal Dominant, Autosomal Recessive, and X-Linked Phenotypes. (1967)

Since 1966, when it first appeared, and through nine editions, McKusick's catalogue has been the definitive reference work on human genetic traits and disorders. Now in two volumes, the tenth edition contains a total of 5,710 entries, 869 more than the ninth, and presents information obtained through March 1, 1992. New in this edition are a guide to the use of OMIM and the genetic code in two alternative easy-to-use formats.
A Scheduling Scheme Based on the SLNR Criterion (2009)

In multiuser MIMO downlink link, maximizing signal to leakage and noise ratio (SLNR) is a good criterion for the design of precoders. In this text, we consider a user scheduling scheme based on this novel criterion. By replacing the WORST user with a Better one again and again according to the proposed updating scheme, we can keep the minimum SLNR of the scheduling users set as large as possible. Simulation results show that the proposed scheme can improve the system performance dramatically.
교육서비스품질이 학생만족도와 학교충성도에 미치는 영향에 관한 연구 (2015)

This research investigated the relationship between service quality, student satisfaction, and behavioral intentions in higher education settings in Korea. SERVPERF and the service quality model for higher education were used to conduct an analysis of a conceptual framework comprised of six dimensions of service quality: administration, faculty, tangibles, reliability, assurance, and curriculum. Of these dimensions, tangibles, faculty, and administration were the important factors for student satisfaction, and they, in turn, showed significant influences on behavioral intentions toward the universities to which the students belonged. These results partially confirmed the linkage between service quality, student satisfaction, and behavioral loyalty in higher education settings in Korea.
Vaccination with the Ad-sig-TAA/ecdCD40L vector followed by vector targeting of chemotherapy completely suppresses the growth of subcutaneous deposits of H2N positive breast cancer in rH2N.Tg mice (2005)

6178 We have designed an adenoviral vector for in vivo activation and tumor antigen loading of dendritic cells (DCs) so that they can more effectively induce a T cell dependent immune response against tumor associated antigens (TAA) positive breast cancer cells. An Ad-sig-TAA/ecdCD40L adenoviral vector which carries a transcription unit preceded by a signal sequence (sig) followed by a TAA fused to the extracellular domain (ecd) of the CD40 ligand (CD40L), is injected subcutaneously (sc). The vector infected cells secrete the TAA/ecdCD40L protein for 10 days. When the CD40L end of this protein binds to the CD40 receptor on the DCs, they are activated, and take up the TAA. The DC’s then migrate to the regional lymph nodes where they induce an expansion of the T cells which are capable of recognizing and killing TAA positive cancer cells, and making antibodies to the TAA. We found that this vector vaccination can suppress the growth of TAA cancer cells for up to one year, even in mice which are anergic to the TAA. Injection (sc) of the Ad-sig-hMUC-1/ecdCD40L vector into the hMUC-1.Tg transgenic mouse, induces resistance to the growth of the hMUC-1 positive LL2/LL1hMUC-1 tumor cells. Injection (sc) of the Ad-sig-rH2N/ecdCD40L vector into mice which were transgenic for the rat Her-2-Neu (rH2N) mice (rH2N.Tg mice) increased: 1) the level of rH2N specific splenic T cells; 2) the level of antibodies against rH2N, and 3) induced resistance to the growth of a syngeneic breast cancer cell line which was rH2N positive. We then infected autologous bone marrow derived DCs with the Ad-sig-rH2N/ecdCD40L vector and injected the vector infected DCs intratumorally. Concomitantly, we intratumorally injected the AdCDIRESE1A vector followed by 10 days of intraperitoneal (ip) 5-Fluorocytosine (5FC). The AdCDIRESE1A vector carries the cytosine deaminase (CD) gene linked to the viral replication E1A gene. CD converts non-toxic 5FC into the chemotherapy agent 5-Fluorouracil (5FU). This combination of intratumoral Ad-sig-rH2N/ecdCD40L infected DCs with intratumoral AdCDIRESE1A/ip5FC completely suppressed the growth of subcutaneous deposits breast cancer derived from rH2N positive tumor cells in rH2N.Tg mice. Neither the intratumoral injection of the Ad-sig-rH2N/ecdCD40L infected DCs alone nor the intratumoral injection of the ADCDIRESE1A/ip5FC alone could completely suppress the growth of the subcutaneous deposits of the rH2N positive syngeneic mouse cells. FACS analysis showed that this vaccine increased the level of effector/memory T cells in the tumor tissue. These results suggest that this vaccine might be of use in reducing the frequency of breast cancer following initial surgery.
<i>Helicobacter pylori</i> VacA Toxin Promotes Bacterial Intracellular Survival in Gastric Epithelial Cells (2006)

Helicobacter pylori colonizes the gastric epithelium of at least 50% of the world's human population, playing a causative role in the development of chronic gastritis, peptic ulcers, and gastric adenocarcinoma. Current evidence indicates that H. pylori can invade epithelial cells in the gastric mucosa. However, relatively little is known about the biology of H. pylori invasion and survival in host cells. Here, we analyze both the nature of and the mechanisms responsible for the formation of H. pylori's intracellular niche. We show that in AGS cells infected with H. pylori, bacterium-containing vacuoles originate through the fusion of late endocytic organelles. This process is mediated by the VacA-dependent retention of the small GTPase Rab7. In addition, functional interactions between Rab7 and its downstream effector, Rab-interacting lysosomal protein (RILP), are necessary for the formation of the bacterial compartment since expression of mutant forms of RILP or Rab7 that fail to bind each other impaired the formation of this unique bacterial niche. Moreover, the VacA-mediated sequestration of active Rab7 disrupts the full maturation of vacuoles as assessed by the lack of both colocalization with cathepsin D and degradation of internalized cargo in the H. pylori-containing vacuole. Based on these findings, we propose that the VacA-dependent isolation of the H. pylori-containing vacuole from bactericidal components of the lysosomal pathway promotes bacterial survival and contributes to the persistence of infection.
Free hydrogen in hydrogen sulfide generated from ferrous sulfide. (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFree hydrogen in hydrogen sulfide generated from ferrous sulfide.Jermain D. Porter Cite this: J. Chem. Educ. 1949, 26, 4, 199Publication Date (Print):April 1, 1949Publication History Received3 August 2009Published online1 April 1949Published inissue 1 April 1949https://doi.org/10.1021/ed026p199RIGHTS & PERMISSIONSArticle Views63Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
A meteoroid on steroids (2013)

We have developed an application called Social Media Illustrator that allows for finding media items on multiple social networks, clustering them by visual similarity, ranking them by different criteria, and finally arranging them in media galleries that were evaluated to be perceived as aesthetically pleasing. In this paper, we focus on the ranking aspect and show how, for a given set of media items, the most adequate ranking criterion combination can be found by interactively applying different criteria and seeing their effect on-the-fly. This leads us to an empirically optimized media item ranking formula, which takes social network interactions into account. While the ranking formula is not universally applicable, it can serve as a good starting point for an individually adapted formula, all within the context of Social Media Illustrator. A demo of the application is available publicly online at the URL http://social-media-illustrator.herokuapp.com/.
A 5'-3' exonuclease from Saccharomyces cerevisiae is required for in vitro recombination between linear DNA molecules with overlapping homology. (1993)

When two linear DNA molecules with overlapping, homologous ends were incubated with a yeast nuclear extract, they recombined at the region of homology to produce a joint molecule. We have identified a 5'-3' exonuclease in the extract that is likely to be responsible for the formation of the observed product. We propose that the exonuclease degrades each substrate to reveal regions of complementary sequence which anneal to form a recombinant product. Consistent with this model, we have partially purified the activity that promotes joint molecule formation and found it to cofractionate with a 5'-3' exonuclease activity through three consecutive chromatography steps. We have further characterized the reaction to determine the optimal length of homology. Substrates with homologous terminal overlaps of 29 to 958 bp were capable of product formation, whereas substrates with longer overlaps were not. Extracts prepared from a number of recombination-defective or nuclease-deficient strains revealed no defect in exonuclease activity, indicating that the reaction is likely to be dependent upon the product of an as yet unidentified gene.
Cryostat for Ferrimagnetic Resonance Experiments (1959)

A cryostat is described consisting of a glass vacuum insulated inner vessel and a Styrofoam outer vessel. The inner Dewar narrows to a fine tip containing the sample at its lower extremity where it protrudes through the outer vessel, and extends into a microwave cavity.
Histone Deacetylase Activity Regulates Chemical Diversity in <i>Aspergillus</i> (2007)

Bioactive small molecules are critical in Aspergillus species during their development and interaction with other organisms. Genes dedicated to their production are encoded in clusters that can be located throughout the genome. We show that deletion of hdaA, encoding an Aspergillus nidulans histone deacetylase (HDAC), causes transcriptional activation of two telomere-proximal gene clusters--and subsequent increased levels of the corresponding molecules (toxin and antibiotic)--but not of a telomere-distal cluster. Introduction of two additional HDAC mutant alleles in a DeltahdaA background had minimal effects on expression of the two HdaA-regulated clusters. Treatment of other fungal genera with HDAC inhibitors resulted in overproduction of several metabolites, suggesting a conserved mechanism of HDAC repression of some secondary-metabolite gene clusters. Chromatin regulation of small-molecule gene clusters may enable filamentous fungi to successfully exploit environmental resources by modifying chemical diversity.
Design and testing of Flux Switched Permanent Magnet (FSPM) Machines (2009)

This thesis offers a short overview of the most important stator mounted permanent magnet machines, with a closer look on the FSPM design. A FSPM machine have been built and tested as a generator, to get a better understanding of the machine concept. The focus of the work have been on the well documented 12/10 (Stator teeth/ Rotor teeth) design while the novel 12/14 pole design have also been tested, as a rotor change is the only difference between the two designs. The machine have been simulated in COMSOL, where inductances, back emf and cogging have been found and compared with the measured results.
CA 19-9 and pancreatic adenocarcinoma (1986)

The diagnostic place value of CA 19-9, a tumor-associated antigen, was tested in 611 patients. This group of patients included 273 patients who suffered from a malignant disease (48 patients with pancreatic carcinomas and 225 patients with extrapancreatic malignant growths) and 338 patients with benign diseases (66 patients with chronic pancreatitis, 36 patients with acute pancreatitis, and 236 patients with general surgical diseases). In 93% of the patients with pancreatic carcinoma (media value, 528 U/ml), in 37% and 19% of the patients with carcinoma of the stomach and colorectal carcinomas (median value 8 U/ml), respectively, the CA 19-9 value was estimated as being above the normal limits of 6 to 37 U/ml. A sensitivity of 93% and a specificity of 85%, as well as a total accuracy of 82%, were established in pancreatic carcinoma during preoperative observation. The preoperatively raised CA 19-9 concentration in patients with pancreatic carcinomas dropped after curative resection of the carcinoma to within normal limits. However, a serum concentration of less than 37 U/ml was not recorded in any CA 19-9 estimation after a palliative surgical intervention, or in any case of inoperable carcinomas.
Novel Pathway of Toluene Catabolism in the Trichloroethylene-Degrading Bacterium G4 (1989)

o-Cresol and 3-methylcatechol were identified as successive transitory intermediates of toluene catabolism by the trichloroethylene-degrading bacterium G4. The absence of a toluene dihydrodiol intermediate or toluene dioxygenase and toluene dihydrodiol dehydrogenase activities suggested that G4 catabolizes toluene by a unique pathway. Formation of a hybrid species of O- and O-labeled 3-methylcatechol from toluene in an atmosphere of O(2) and O(2) established that G4 catabolizes toluene by successive monooxygenations at the ortho and meta positions. Detection of trace amounts of 4-methylcatechol from toluene catabolism suggested that the initial hydroxylation of toluene was not exclusively at the ortho position. Further catabolism of 3-methylcatechol was found to proceed via catechol-2,3-dioxygenase and hydroxymuconic semialdehyde hydrolase activities.
Using Segmented Right-Deep Trees for the Execution of Pipelined Hash Joins (1992)

In this paper, we explore the execution of pipelined hash joins in a multiprocessor-based database system. To improve the query execution, an innovative approach on query execution tree selection is proposed to exploit segmented right-deep trees, which are bushy trees of right-deep subtrees. We first derive an analytical model for the execution of a pipeline segment, and then, in light of the model, develop heuristic schemes to determine the query execution plan based on a segmented right-deep tree so that the query can be efficiently executed. As shown by our simulation, the proposed approach, without incurring additional overhead on plan execution, possesses more flexibility in query plan generation, and leads to query plans of significantly better performance than those achievable by the previous schemes using right-deep trees. 1 Introduction In relational database systems, joins are the most expensive operations to execute, especially with the increases in database size and query ...
Cultural Competence as New Racism: Working as Intended? (2021)

This article is referred to by:Health Disparities, Systemic Racism, and Failures of Cultural Competence: Authors' Response to Commentaries
Melatonin enhances cortisol levels in aged but not young women (1995)

In spite of animal data showing an effect of melatonin in the regulation of the hypothalamus-pituitary-adrenal (HPA) axis, no effect of melatonin on cortisol has been evidenced in young men. Gender and aging are believed to influence the regulation of the HPA axis, and may thus modulate the melatonin effect on cortisol. In this study we investigated whether an effect of melatonin on cortisol can be observed in women of different age. Six young women in early follicular phase (22-32 years; EFW) and eight aged women in postmenopause (54-62 years; PMW) were studied. At 08.00 h on two consecutive days each woman received, randomly and in double-blind fashion, a pill of placebo or melatonin (100 mg). Serum levels of melatonin and cortisol were evaluated at 20-min intervals for 48 h. In comparison to EFW, PMW showed an earlier onset of nocturnal melatonin (p < 0.05) and cortisol rise (p < 0.01) and higher cortisol levels at lunch (p < 0.05) and early evening (p < 0.01). Melatonin administration did not modify serum cortisol levels in EFW but elicited a marked increase of daytime cortisol levels in PMW (p < 0.02). The present data reveal that in aged PMW the cortisol levels are enhanced at selected circadian times and are stimulated by melatonin.