gebhart/patrepeval huggingface dataset:
Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults (2003)

Zincum gluconicum nasal gel shortens duration and reduces symptom severity of the common cold in healthy adults, when started within 24-48 h of the onset of illness.
TagOrbitals (2006)

With the rise of web-based tagging systems, it has become important to help users search and browse the index of tags that are being created. One promising approach is visualization, but existing techniques rely on hard-to-interpret network diagrams or focus only on a small subset of a collection. This sketch introduces TagOrbitals, a technique that can display an entire index at once, while simultaneously showing details of individual tags and items.
The social state (1993)

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BEHAVIOR OF CRYSTALLINE ORIENTATION AND THE MECHANICAL PROPERTIES OF THE BIAXIALLY STRETCHED POLYPROPYLENE FILMS PREPARED BY DRY-PROCESS (1970)

This report shows the effects of crystalline orientation on the mechanical properties of the biaxially stretched polypropylene films prepared by dry-process.In this study, polypropylene fiims T-die extruded with 150μ thickness and random orientation were used. In a recirculating hot-air bath at 145°C, and at constant rate 1600%/min, the films were stretched to various extensions using the filmstretcher, (i.e., uniaxially stretched under the conditions of free width and/or constant width, two-way successively, and simultaneously biaxially stretched), and then heat set at 150°C for 10min.Mechanical properties of the variously stretched films were evaluated by stress-strain curves measured at 20°C, 65% R. H. On the other hand, the behaviors of crystalline orientation and crystallization in these stretched films were investigated by the x-ray diffractogram and density measruement.The following results were obtained:(1) The crystalline orientation of uniaxially stretched films under the conditions of free width has uniaxial orientation of which crystal c-axis is oriented parallel to the tensile axis, cylindrical symmetry around the stretching direction, as a fiber. For the uniaxially stretched films with the constant width, however, the crystallites have uniplanar-axialy orient in the way that the c- and a′-axies orient parallel to a filmsurface plane and the c-axis parallel to the tensile axis. The difference of both mechanical properties was connected with that of the orientation.(2) The crystalline orientation of two-way successively biaxially stretched film varied depending on streching ratio, that is by successive stretching to transverse directon, the initiial uniplanaraxial orientation changes into the intermitted state, and finally approaches to the uniplanar-axial orientation to a transverse dirction. During the stretching, the crystallite begins to turn to transverse direction, and this process is presumably related to the unfolding of crystals. After the “blance point”, rectystallization seems to take place.(3) The crystalline orientation of simultaneously biaxially stretched films is uniplanar orientation at all stretch ratio. Therefore, the equal mechanical properties are obtained within the stretched plane at all stretched ratio.
Suppressors of a UGG missense mutation in Escherichia coli (1980)

As part of our investigation of tRNA structure-function relationships, we isolated and preliminarily characterized translational suppressors of the tryptophan codon UGG in a trpA missense mutant of Escherichia coli. the parent strain also contained two other mutant alleles relevant to the suppressor search; these were supD, which codes for a serine-inserting amber suppressor tRNA, and gly V55, the gene for a GGA/G-reading mutationally altered glycine tRNA. On the basis of map location, reversed-phase (RPC-5) column chromatography of glycyl-tRNA, and codon response, several classes have been distinguished so far. The number of suppressors in each class, their codon responses, and their apparent genic identities, respectively, are as follows: class 1--4 suppressors, UGG, supD; class 2--12 suppressors, UGG, glyU; class 3--9 suppressors, UGA and UGG, glyT; class 4--2 suppressors, UGG, glyT; class 5--7 suppressors, UGG, gly V55. Besides these, one suppressor retains supD activity, but so far its map location has not been distinguished from that of supD. Another suppressor clearly does not map near supD or any of the glycine tRNA genes mentioned. These last two suppressors may represent novel missense suppressors such as misacylated tRNA's or mutationally altered aminoacyl-tRNA synthetases, tRNA modification enzymes, or ribosomes. Finally, three other suppressors were obtained from a strain containing glyT56, the gene for an AGA/G-reading form of glyT tRNA. All three occurred at the expense of glyT56 activity and exhibited the the transductional linkage to argH that is characteristic of glyT.
Transfer function analysis of dynamic cerebral autoregulation: A white paper from the International Cerebral Autoregulation Research Network (2016)

Cerebral autoregulation is the intrinsic ability of the brain to maintain adequate cerebral perfusion in the presence of blood pressure changes. A large number of methods to assess the quality of cerebral autoregulation have been proposed over the last 30 years. However, no single method has been universally accepted as a gold standard. Therefore, the choice of which method to employ to quantify cerebral autoregulation remains a matter of personal choice. Nevertheless, given the concept that cerebral autoregulation represents the dynamic relationship between blood pressure (stimulus or input) and cerebral blood flow (response or output), transfer function analysis became the most popular approach adopted in studies based on spontaneous fluctuations of blood pressure. Despite its sound theoretical background, the literature shows considerable variation in implementation of transfer function analysis in practice, which has limited comparisons between studies and hindered progress towards clinical application. Therefore, the purpose of the present white paper is to improve standardisation of parameters and settings adopted for application of transfer function analysis in studies of dynamic cerebral autoregulation. The development of these recommendations was initiated by (but not confined to) theCerebral Autoregulation Research Network(CARNet -www.car-net.org).
Filtration of Nanoparticles with Dimethyldioctadecylammonium Bromide Treated Microporous Polypropylene Filters (1997)

Microporous polypropylene membrane filters are modified with a cationic surfactant, dimethyldioctadecylammonium bromide (DDAB), to create a charged surface. Negatively charged nanoparticles can then be filtered by utilizing the electrostatic interaction between the charged particles and the polar heads of the surfactants adsorbed on the filters. The study focuses on particle adsorption and particle filtration. Particle adsorption studies have shown that particle adsorption can be increased significantly with this treatment due to Coulombic attraction. Filtration results for 60 nm negatively charged particles (carboxylate modified copolymer) filtered through DDAB treated filters show a significant increase in particle capture efficiency. Capture efficiency is dependent on the pH of the suspension due to competitive adsorption between the hydroxide ions and the negatively charged nanoparticles. As the mean pore diameter increases, capture efficiency decreases due to the increase in distance between the particles and the charged filter surface. Filtration efficiency can be increased from 10% to 95% by surface modification of the filters.
N‐Terminal protein modifications in an insect cell‐free protein synthesis system and their identification by mass spectrometry (2006)

To evaluate the ability of an insect cell-free protein synthesis system to generate proper N-terminal cotranslational protein modifications such as removal of the initiating Met, N-acetylation, and N-myristoylation, several mutants were constructed using truncated human gelsolin (tGelsolin) as a model protein. Tryptic digests of these mutants were analyzed by MALDI-TOF MS and MALDI-quadrupole-IT-TOF MS. The wild-type tGelsolin, which is an N-myristoylated protein, was found to be N-myristoylated when myristoyl-CoA was added to the in vitro translation reaction mixture. N-myristoylation did not occur on the Gly-2 to Ala mutant, in which the N-myristoylation motif was disrupted, whereas this mutant was found to be N-acetylated after removal of the initiating Met. Analyses of Gly-2 to His and Leu-3 to Asp mutants revealed that the amino acids at positions 2 and 3 strongly affect the susceptibility of the nascent peptide chain to removal of the initiating Met and to N-acetylation, respectively. These results suggest that N-terminal modifications occurring in the insect cell-free protein synthesis system are quite similar to those observed in the mammalian protein synthesis system. Thus, a combination of the cell-free protein synthesis system with MS is an effective strategy to analyze protein modifications.
Reactive Nitrogen Species-Induced Cell Death Requires Fas-Dependent Activation of c-Jun N-Terminal Kinase (2004)

Nitrogen dioxide is a highly toxic reactive nitrogen species (RNS) recently discovered as an inflammatory oxidant with great potential to damage tissues. We demonstrate here that cell death by RNS was caused by c-Jun N-terminal kinase (JNK). Activation of JNK by RNS was density dependent and caused mitochondrial depolarization and nuclear condensation. JNK activation by RNS was abolished in cells lacking functional Fas or following expression of a truncated version of Fas lacking the intracellular death domain. In contrast, RNS induced JNK potently in cells expressing a truncated version of tumor necrosis factor receptor 1 or cells lacking tumor necrosis factor receptor 1 (TNF-R1), illustrating a dependence of Fas but not TNF-R1 in RNS-induced signaling to JNK. Furthermore, Fas was oxidized, redistributed, and colocalized with Fas-associated death domain (FADD) in RNS-exposed cells, illustrating that RNS directly targeted Fas. JNK activation and cell death by RNS occurred in a Fas ligand- and caspase-independent manner. While the activation of JNK by RNS or FasL required FADD, the cysteine-rich domain 1 containing preligand assembly domain required for FasL signaling was not involved in JNK activation by RNS. These findings illustrate that RNS cause cell death in a Fas- and JNK-dependent manner and that this occurs through a pathway distinct from FasL. Thus, avenues aimed at preventing the interaction of RNS with Fas may attenuate tissue damage characteristic of chronic inflammatory diseases that are accompanied by high levels of RNS.
First investigation of ambient positive-ion composition to 219 km by rocket-borne spectrometer (1955)

The ambient positive-ion composition of the upper atmosphere in the range 8 to 49 atomic mass units (AMU) was measured between 93 and 219 km by means of a Bennett radio-frequency mass spectrometer. The experiment was flown in the Navy Viking 10 rocket, launched from White Sands Proving Ground, Las Cruces, New Mexico, at 10h 00m MST, May 7, 1954. The most prominent ion peaks found between 93 and 124 km on the ascent were at 16, 26, 30, and 32 AMU. Other less prominent peaks occurred at 12, 18, 19, 21, 23, 38, and 45 AMU. From 124 to 219 km, ions of 16 and 32 AMU persisted. The results of this investigation are to be considered preliminary and need further verification, not only because the data were obtained from only one flight, but also because of complications introduced by a charge acquired by the rocket and by the evolution of gas from the rocket.
Micro‐Raman spectroscopy used to identify and grade human skin pilomatrixoma (2005)

Raman microspectroscopy was applied to analyze the changes in structural conformation and chemical composition of the mass of human skin pilomatrixoma (PMX). The normal skin dermis, collagen type I, and hydroxyapatite (HA) were used as control. The excised specimens from two patients diagnosed as a typical PMX were detected, in which one specimen was a soft mass, but the other was a hard mass with somewhat calcified deposits via histopathological examination. The Raman spectrum of normal skin dermis was found to be similar to the Raman spectrum of collagen type I, confirming that the collagen type I was a predominant component in normal skin dermis. The differences of Raman peak intensity between normal skin dermis and soft or hard PMX mass were obvious at 1,622-1,558, 1,400-1,230, 1,128, 1,000-850, 749, and 509 cm(-1). In particular, the peak at 1,665 cm(-1) assigned to amide I band shifted to 1,655 cm(-1) and the peak at 1,246 cm(-1) corresponding to amide III band was reduced in its intensity in hard PMX mass. The significant changes in collagen content and its structural conformation, the higher content of tryptophan, and disulfide formation in PMX masses were markedly evidenced. In addition, the shoulder and weak peak at 960 cm(-1) assigned to the stretching vibration of PO(4) (3-) of HA also appeared respectively in the Raman spectra of soft and hard PMX masses, suggesting the occurrence of calcification of HA in the PMX tissue, particularly in the hard PMX mass. The result indicates that the micro-Raman spectroscopy may provide a highly sensitive and specific method for identifying normal skin dermis and how it differs in chemical composition from different PMX tissues.
Video editing support system based on video grammar and content analysis (2003)

Video editing is the work to produce the final videos with certain duration by finding and selecting appropriate shots from the material videos and connecting them. In order to produce the excellent videos, this process is generally conducted according to the special rules called "video grammar". In this paper, we propose an intelligent support system for the video editing where metadata are extracted automatically and then the video grammars are applied to the extracted metadata.
Temperature Measurement of Power Semiconductor Devices by Thermo-Sensitive Electrical Parameters—A Review (2011)

This paper proposes a synthesis of different electrical methods used to estimate the temperature of power semiconductor devices. The following measurement methods are introduced: the voltage under low current levels, the threshold voltage, the voltage under high current levels, the gate-emitter voltage, the saturation current, and the switching times. All these methods are then compared in terms of sensitivity, linearity, accuracy, genericity, calibration needs, and possibility of characterizing the thermal impedance or the temperature during the operation of the converter. The measurement of thermo-sensitive parameters of wide bandgap semiconductors is also discussed.
In Vitro Cartilage Regeneration From Proliferated Adult Elastic Chondrocytes (2005)

The purpose of this study was to investigate cellular feasibility in the proliferation and differentiation status of adult chondrocytes for cartilage regeneration in comparison to fetal chondrocytes. Primary cells were isolated from adult (n = 6) and fetal (n = 6) sheep ear cartilages and expanded in 10% fetal bovine serum (FBS) containing Ham's F12 medium, in which adult and fetal cell proliferation rates were compared using a WST-1 assay kit. Approximately 4 million cells were seeded onto each 1 x 1 x 0.2-cm (200 microL) nonwoven fabric scaffold made from polyglycolic acid. Cell/polymer constructs were cultured in serum-free DMEM/F12 medium supplemented with 5 ng/mL TGF-beta2 and 5 ng/mL des(1-3)IGF-I (adult chondrocytes, group A) or in 10% FBS containing Ham's F12 medium (adult chondrocytes, group B, and fetal chondrocytes, group C) as controls in a rotating bioreactor for 6 weeks. The proliferation assay showed that fetal cells had a significantly better growth potential than did adult cells. Histology and extracellular matrix analyses revealed that groups A and C qualitatively displayed better matrix deposition than did group B. In conclusion, although adult sheep elastic chondrocytes had less growth potential than did fetal cells, the serum-free medium supplemented with growth factors significantly enhanced the production of cartilage matrix secreted from proliferated adult sheep elastic chondrocytes.
DISSOCIATION OF γ-GLOBULIN (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDISSOCIATION OF γ-GLOBULINGerald M. EdelmanCite this: J. Am. Chem. Soc. 1959, 81, 12, 3155–3156Publication Date (Print):June 1, 1959Publication History Published online1 May 2002Published inissue 1 June 1959https://doi.org/10.1021/ja01521a071Request reuse permissionsArticle Views470Altmetric-Citations147LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (268 KB) Get e-Alertsclose Get e-Alerts
Increased neuropeptide Y content in individual hypothalamic nuclei, but not neuropeptide Y mRNA, in diet-induced obesity in rats (1992)

Neuropeptide Y (NPY) is the most powerful appetite stimulant known, and chronic administration leads to obesity. The hypothalamic content of NPY varies with nutritional status, suggesting that it is of physiological importance. We measured NPY in specific hypothalamic nuclei and NPY mRNA in the hypothalamus by Northern blotting in rats made obese by feeding a highly palatable diet compared with controls fed standard chow. In animals fed the palatable diet, NPY concentrations were increased in the paraventricular nucleus (mean +/- S.E.M.; 19.5 +/- 2.3 vs 11.1 +/- 1.1 fmol/micrograms protein, P less than 0.02), the arcuate nucleus (20.4 +/- 3.3 vs 9.3 +/- 0.6 fmol/micrograms protein, P less than 0.01), the medial preoptic area (9.1 +/- 0.9 vs 5.9 +/- 0.7 fmol/micrograms protein, P less than 0.02) and the anterior hypothalamus (2.7 +/- 0.2 vs 2.0 +/- 0.1 fmol/micrograms, P less than 0.02). Hypothalamic NPY mRNA measured by Northern blot analysis was, however, unchanged. These results suggest that the increase in NPY was due to decreased release rather than increased NPYergic activity. The findings are in accord with the neuroendocrine disturbance and increased thermogenesis observed in this model of obesity.
Optical perfect shuffle (1986)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Adolf W. Lohmann, W. Stork, and G. Stucke, "Optical perfect shuffle," Appl. Opt. 25, 1530-1531 (1986) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Time-dependent density-functional theory in the projector augmented-wave method (2008)

We present the implementation of the time-dependent density-functional theory both in linear-response and in time-propagation formalisms using the projector augmented-wave method in real-space grids. The two technically very different methods are compared in the linear-response regime where we found perfect agreement in the calculated photoabsorption spectra. We discuss the strengths and weaknesses of the two methods as well as their convergence properties. We demonstrate different applications of the methods by calculating excitation energies and excited state Born-Oppenheimer potential surfaces for a set of atoms and molecules with the linear-response method and by calculating nonlinear emission spectra using the time-propagation method.
Computing in memory with FeFETs (2018)

Data transfer between a processor and memory frequently represents a bottleneck with respect to improving application-level performance. Computing in memory (CiM), where logic and arithmetic operations are performed in memory, could significantly reduce both energy consumption and computational overheads associated with data transfer. Compact, low-power, and fast CiM designs could ultimately lead to improved application-level performance. This paper introduces a CiM architecture based on ferroelectric field effect transistors (FeFETs). The CiM design can serve as a general purpose, random access memory (RAM), and can also perform Boolean operations ((N)AND, (N)OR, X(N)OR, INV) as well as addition (ADD) between words in memory. Unlike existing CiM designs based on other emerging technologies, FeFET-CiM accomplishes the aforementioned operations via a single current reference in the sense amplifier, which leads to more compact designs and lower power. Furthermore, the high Ion/Ioff ratio of FeFETs enables an inexpensive voltage-based sense scheme. Simulation-based case studies suggest that our FeFET-CiM can achieve speed-ups (and energy reduction) of ~119X (~1.6X) and ~1.97X (~1.5X) over ReRAM and STT-RAM CiM designs with respect to in-memory addition of 32-bit words. Furthermore, our approach offers an average speedup of ~2.5X and energy reduction of ~1.7X when compared to a conventional (not in-memory) approach across a wide range of benchmarks.