gebhart/patrepeval huggingface dataset:
Excimer laser angioplasty: Tissue ablation, arterial response, and fiber optic delivery (1987)

The results of recent work directed towards the application of excimer lasers to angioplasty are presented. Several laser-tissue interactions are examined, including the effect of the XeCl laser optical pulse duration (7-300 ns) on the threshold fluence for ablation of arterial wall and on the quality of the cut in human postmortem artery, the potential for altering the ablation threshold fluence of arterial plaque in swine by treatment with hematoporphyrin derivative, and the healing response of swine arterial wall to surgical irradiation with an argon laser and a pulsed XeCl laser. The dependence of damage thresholds and transmission properties of selected commercial fused silica fibers on the laser pulsewidth and wavelength are determined.
A schematic driven synthesis tool for analog circuits (2003)

The integration of a synthesis tool for analog circuit in a general design framework is presented. It is based on a schematic editor and uses the graphical interface to visualize results of the synthesis. Main features of the tool are openness to external topologies, technologies (CMOS and BiCMOS) extended characterization capabilities and integration in a general design framework. The synthesis part is done by the program IDAC. The tool is integrated into the design framework UNICAD developed by SGS Thomson.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dissociation rate constants of alkylbenzenes from hot molecules formed by 158-nm (F2 laser) irradiation (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDissociation rate constants of alkylbenzenes from hot molecules formed by 158-nm (F2 laser) irradiationTetsuya Shimada, Yuichi Ojima, Nobuaki Nakashima, Yasukazu Izawa, and Chiyoe YamanakaCite this: J. Phys. Chem. 1992, 96, 15, 6298–6302Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/j100194a037https://doi.org/10.1021/j100194a037research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Adaption of the discrete rate-based simulation paradigm for tactical supply chain decisions (2014)

The relative novel discrete rate-based simulation paradigm combines the advantages of the discrete event-based and the system dynamics simulation paradigms. Although its applicability is generally acknowledged in the context of supply chain management, no research works exist, that allow for a direct modeling and simulation of supply chain planning decisions within this paradigm. This paper therefore presents necessary adaptations of the discrete rate-based simulation paradigm for tactical supply chain planning decisions. Our main research contribution lies in extending the discrete rate-based simulation with modeling and material flow controlling mechanisms for enabling a simple implementation and simulation of tactical supply chain planning tasks. To evaluate different planning decisions in this context a multitude of simulation runs are necessary, creating a need for fast simulation approaches. Thus, we show formally, that discrete rate-based simulation models can generally be computed faster than commonly used discrete event-based simulation models.
Essential in Vivo Roles of the C-type Lectin Receptor CLEC-2 (2010)

CLEC-2 has been described recently as playing crucial roles in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis. The snake venom rhodocytin is known as a strong platelet activator, and we have shown that this effect is mediated by CLEC-2 (Suzuki-Inoue, K., Fuller, G. L., García, A., Eble, J. A., Pöhlmann, S., Inoue, O., Gartner, T. K., Hughan, S. C., Pearce, A. C., Laing, G. D., Theakston, R. D., Schweighoffer, E., Zitzmann, N., Morita, T., Tybulewicz, V. L., Ozaki, Y., and Watson, S. P. (2006) Blood 107, 542-549). Podoplanin, which is expressed on the surface of tumor cells, is an endogenous ligand for CLEC-2 and facilitates tumor metastasis by inducing platelet aggregation. Mice deficient in podoplanin, which is also expressed on the surface of lymphatic endothelial cells, show abnormal patterns of lymphatic vessel formation. In this study, we report on the generation and phenotype of CLEC-2-deficient mice. These mice are lethal at the embryonic/neonatal stages associated with disorganized and blood-filled lymphatic vessels and severe edema. Moreover, by transplantation of fetal liver cells from Clec-2(-/-) or Clec-2(+/+) embryos, we were able to demonstrate that CLEC-2 is involved in thrombus stabilization in vitro and in vivo, possibly through homophilic interactions without apparent increase in bleeding tendency. We propose that CLEC-2 could be an ideal novel target protein for an anti-platelet drug, which inhibits pathological thrombus formation but not physiological hemostasis.
Cloning, Functional Expression, and Characterization of CYP709C1, the First Sub-terminal Hydroxylase of Long Chain Fatty Acid in Plants (2005)

We cloned and characterized CYP709C1, a new plant cytochrome P450 belonging to the P450 family, that so far has no identified function except for clustering with a fatty acid metabolizing clade of P450 enzymes. We showed here that CYP709C1 is capable of hydroxylating fatty acids at the omega-1 and omega-2 positions. This work was performed after recoding and heterologous expression of a full-length cDNA isolated from a wheat cDNA library in an engineered yeast strain. Investigation on substrate specificity indicates that CYP709C1 metabolizes different fatty acids varying in their chain length (C12 to C18) and unsaturation. CYP709C1 is the first identified plant cytochrome P450 that can catalyze sub-terminal hydroxylation of C18 fatty acids. cis-9,10-Epoxystearic acid is metabolized with the highest efficiency, i.e. K((m)(app)) of 8 microM and V(max(app)) of 328 nmol/min/nmol P450. This, together with the fact that wheat possesses a microsomal peroxygenase able to synthesize this compound from oleic acid, strongly suggests that it is a physiological substrate. Hydroxylated fatty acids are implicated in plant defense events. We postulated that CYP709C1 could be involved in plant defense by producing such compounds. This receives support from the observation that (i) sub-terminal hydroxylation of 9,10-epoxystearic acid is induced (15-fold after 3 h) in microsomes of wheat seedlings treated with the stress hormone methyl jasmonate and (ii) CYP709C1 is enhanced at the transcriptional level by this treatment. CYP709C1 transcript also accumulated after treatment with a combination of the safener naphthalic acid anhydride and phenobarbital. This indicates a possible detoxifying function for CYP709C1 that we discussed.
Law, Policy and Practice: The United Nations Collective Security Regime and the Contribution of the New Zealand Defence Force (2009)

This article considers New Zealand's participation in the United Nations' (UN) regime of collective security as embodied in the Charter of the United Nations (the Charter). It focuses on the participation of the New Zealand Defence Force (NZDF) in three peace support operations: Cambodia, East Timor/Timor Leste and Afghanistan. These three case studies allow consideration of the manner in which New Zealand has contributed to an evolving security environment which has seen a dynamic interpretation of the legal bases by which the UN seeks to fulfil its purpose of maintaining international peace and security. The work of the NZDF in these three operations demonstrates both how the law and policy considerations underpinning peace support operations play out in practice. The NZDF's participation in peace support operations reaffirms that the nature of peace and security is a complex combination of international and domestic law and policy. Finally, the reality of the work of the NZDF also exemplifies the porous nature of the interrelationship between war-fighting and peace support. The multi-faceted functions of the NZDF, stemming from the complex combination of law and policy, provide tangible examples of the manner in which military functions positively affect socio-economic conditions and the furtherance of peace and security and, as such, are demonstrative of the evolving collective security regime.
NAUTILE: a safe environment for silicon compilation (2002)

This paper deals with an environment for IC's layout, to act as a framework for the design of module generators for behavioral silicon compilation. It is built around an object oriented data manager that handles hierarchical design, and multiple representations, with emphasis on a safe design methodology. This manager also allows the use of externally defined elements, and the integration of tools written for other systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Multi-story power delivery for supply noise reduction and low voltage operation (2005)

This paper presents a multi-story power delivery scheme which shows significant reduction of supply noise and power consumption compared to conventional power delivery scheme. To maximize the effectiveness of the proposed scheme, a digital voltage regulator is designed to balance the current dissipation of circuits in different voltage domains. Data transfer circuits based on capacitive coupling are developed for efficient inter-story data communication. Simulation results show 66% and 67% reduction of IR noise and Ldi/dt noise, respectively, while the total power consumption was reduced by 5% compared to a conventional power delivery scheme
Mechanical Properties of Polymers (2013)

Abstract Polymers are being used in every day consumer products manufacturing and various engineering applications. They provide design and manufacturing flexibility, as well as desirable combinations of properties. However, successful implementation of any polymer requires a basic understanding of its mechanical behavior and what factors affect that behavior. The chapter overviews the basic principles of polymer mechanical behavior which includes a discussion of the microstructure and morphology of polymers, stress‐strain behavior, time–temperature relationships, deformation mechanisms, fracture mechanics, polymer toughening, and reinforced polymers (and composites). The behavior of polymers in load‐bearing applications is also described, with introductions to creep, fatigue, and high‐strain rate performance.
Proximal promoter region is sufficient to regulate tissue‐specific expression of UDP‐galactose: Ceramide galactosyltransferase gene (1998)

UDP-galactose:ceramide galactosyltransferase (CGT) is the enzyme which catalyzes the final step of the biosynthesis of galactocerebroside (GalC), the most abundant glycolipid in myelin. We identified regulatory elements which are related to the tissue-specific expression of the mouse CGT gene by promoter assay using chimeric CGT-luciferase constructs. By comparing promoter activity in oligodendroglial CG4 cells and NIH3T3 fibroblasts, only a few hundred base pairs spanning from −309 to −98 were shown to be necessary for the tissue-specific activity of CGT promoter. A negative regulatory element was found in a more distal region, from −709 to −527, and it also worked in tissue-specific manner. Sequence analysis suggests that several known elements found commonly in myelin-related genes may explain these tissue-specific regulations of the transcriptional activity. J. Neurosci. Res. 52:757–765, 1998. © 1998 Wiley-Liss, Inc.
<p>KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA</p> (2019)

KIAA1429 facilitated migration and invasion of HCC by inhibiting ID2 via upregulating m6A modification of ID2 mRNA.
New histamine alkaloids from a Glochidion species (1966)

S. R. Johns and J. A. Lamberton, Chem. Commun. (London), 1966, 312b DOI: 10.1039/C1966000312B
Association of tissue promoter methylation levels of <i>APC</i>, <i>TGFβ2</i>, <i>HOXD3</i> and <i>RASSF1A</i> with prostate cancer progression (2011)

Aberrant promoter methylation is known to silence tumor-suppressor genes in prostate cancer (PCa). We correlated quantitative promoter methylation levels of APC, TGFβ2 and RASSF1A in 219 radical prostatectomies diagnosed between 1998 and 2001 with clinicopathological follow-up data available including Gleason Pattern (GP), Gleason Score (GS) and pathological stage and explored their potential in predicting biochemical recurrence using univariate and multivariate analyses. We observed that the average methylation levels of APC increased significantly from GS ≤ 6 to GS7, and pT2 to pT3a, and that of TGFβ2 increased from GS ≤ 6 to GS7, but not for RASSF1A. PCa samples were also stratified into high methylation (HM) and low methylation (LM) groups based on the PMR scores of all cases analyzed for each marker. The HM frequency of APC was greater in pT3a than pT2, and in GS ≥ 8 than GS ≤ 6. The HM frequency also increased significantly from GP3 to GP4 for APC, TGFβ2 and RASSF1A. APC methylation level was a significant predictor of biochemical recurrence in univariate analysis (p-value = 0.028). Finally, we combined methylation data of these three genes with the previously reported novel methylation biomarker HOXD3. Quantitative methylation assessment of a multiplex panel of markers, consisting of APC, HOXD3 and TGFβ2, outperforms any single marker for the prediction of biochemical recurrence (p-value = 0.017). Our study demonstrated that quantitative increase in promoter methylation levels of APC, HOXD3 and TGFβ2 are associated with PCa progression.
Organophosphorus compounds. IV.—2‐[Diethoxy or ethoxy (ethyl) phosphinylthio‐ and diethoxy or ethoxy (ethyl) phosphinothioylthio‐methyl] benzimidazoles (1968)

Abstract Several 2‐chloromethylbenzimidazoles were prepared and condensed with potassium diethyl phosphoro‐ and phosphono‐ thiolothionates and thiolates for inseeticidal and acaricidal studies.
Dry sintering of latex particles in pigmented coatings. I. Influence on coating structure and properties (1981)

Abstract When a clay–latex coating, dried below the minimum film‐forming temperature (MFT) of the latex, was subsequently heated above the MFT, its opacity and brightness were considerably enhanced. The improvement in optical properties was optimum in the latex content range of 20–40 parts per 100 parts of clay. The sintering of the latex particles, brought about by the thermal treatment, increased the average size of the microvoids to a diameter that is optimum for the scattering of light, without significantly affecting the total void content. Data on light‐scattering coefficient, porosity, gloss, brightness, and oil permeability are discussed and compared to those of conventional coatings, i.e., of coatings dried above the MFT of the latex. Similar improvements in optical properties were obtained when coalescence of the latex particles was induced by exposure to a solvent.
Promising Spectroscopic Techniques for the Portable Detection of Condensed‐Phase Contaminants on Surfaces (2007)

Abstract Techniques for the detection of hazardous low‐volatility contaminants on surfaces are reviewed. These techniques include both point detection (i.e., in situ) and standoff detection (i.e., detection beyond the effective range of the hazard). For low‐volatility agents, a standoff distance may range from a few centimeters to hundreds of meters, depending upon physical and deposition characteristics. This survey has been restricted to optical techniques that can detect contaminants on “realistic” surfaces (including civilian and military painted surfaces) and are hand‐held or man‐portable or those techniques that are anticipated to be made hand‐held or man‐portable within 5 years to one decade. A range of spectroscopic techniques are treated along with their requirements for power and consumables. Detection limits for these techniques are presented in the context of in‐service technologies and in the context of civilian and military toxicity/exposure limits for various chemical warfare agents. The effects of aerosols on various spectroscopic techniques are reviewed.
Modeling ring cleaving dioxygenases: Complexes of iron(II) with tridentate ligands and their reactivity with catecholates and phenolates (2009)

Thesis (Ph. D.)--University of Rochester. Dept. of Chemistry, 2010.
Long-term outcomes of surgical treatment for pulmonary carcinoid tumors: 20 years' experience with 131 patients. (2012)

Bronchoplastic surgery should be considered whenever possible for central carcinoids. Systematic lymphadenectomy is recommended for bronchial carcinoid patients. Histology and nodal status were significant independent prognostic factors of overall survival of patients with bronchial carcinoid.
Effect of Pyridoxamine on Acrylamide Formation in a Glucose/Asparagine Model System (2009)

The effect of pyridoxamine (PM) on the reduction of acrylamide (AA) formation in a low-moisture equimolar glucose/asparagine model system was investigated. Formation/elimination kinetics of acrylamide was carried out at temperatures between 120 and 180 degrees C. Time courses of glucose, asparagine, pyridoxamine, 3-aminopropionamide (3-APA), acrylamide, and browning were measured to get more insight on the mechanism of action of PM. PM exhibited an inhibitory effect on AA formation at all temperatures studied, but became more relevant at 160 and 180 degrees C (up to 51% reduction). Degradation rates of glucose and asparagine were not significantly affected by PM, but PM was rapidly consumed in the glucose/asparagine system. Browning was significantly suppressed by addition of PM in the system, and formation of 3-APA was increased as compared to control. In comparison with pyridoxal, pyridoxine, and ascorbic acid, PM exerted the highest inhibition activity against AA formation, and a clear dose-response was observed. The nucleophilic aminomethyl group of PM was crucial for the exertion of an inhibition effect more than double those other B6 vitamers. The action mechanism of PM was attributable to its structural features that have the capacity to scavenge intermediary dicarbonyls formed during sugar degradation and advanced stages of the Maillard reaction. These findings open new possibilities for strategies in acrylamide mitigation where formation of reactive dicarbonyls should be carefully considered.
Are We Engineering Ourselves out of Manufacturing Jobs (2006)

Since the 1970s, productivity growth in the manufacturing sector has outpaced the overall economy, yet the sector?s share of the workforce has declined dramatically. This leads us to ask if we are in fact engineering ourselves out of jobs. This Economic Commentary explores the relationship between productivity and employment and points out why this apparently straightforward relationship may be more complicated than it appears.
Minimal-sensing, passive force identification techniques for a composite structural missile component (2009)

Structural health monitoring systems are often limited to the use of one sensor due to cost, complexity, and weight restrictions. Therefore, there is a need to develop load and damage identification techniques that utilize only one sensor. Two passive force estimation techniques are investigated in this work. The techniques focus on either the shape or the amplitude of the magnitude of the applied force in the frequency domain. Both techniques iteratively reduce an underdetermined set of equations of motion into many overdetermined systems of equations to solve for the force estimates. The techniques are shown to locate and quantify impulsive impacts with over 97% accuracy and non-impulsive impacts with at least 87% accuracy. A filament-wound rocket motor casing is used as a test structure. Impacts not acting at a specific input degree of freedom are also accurately located depending on the distance away from the modeled input degrees of freedom, and damaging impact forces are quantified by making assumptions about the impulsive nature of the applied force.
Motion Mode Recognition for Indoor Pedestrian Navigation Using Portable Devices (2015)

While indoor portable navigation using portable devices is becoming increasingly required, it faces many challenges in obtaining accurate positioning performance. One of the methods to improve navigation results is to recognize the mode of motion of the user carrying the portable device containing low-cost microelectromechanical systems (MEMS) motion sensors. Pattern recognition methodology has been employed to detect a group of motion modes that are common indoors, namely, walking, stationary, going up/down stairs, standing on an escalator, walking on an escalator, standing on a moving walkway, and walking on a moving walkway. The performance of the motion mode recognition module was examined on different types of mobile computing devices, including various brands of smartphones, tablets, smartwatches, and smartglasses, and the results obtained showed the capability of enhancing positioning performance. The module does not require satellite or wireless positioning signals, and depends only on MEMS sensors.
One-Sided Nondestructive Evaluation of CFRP Composites By Using Ultrasonic Sound (2011)

It is well known that stiffness of composites depends on layup sequence of CFRP(carbon fiber reinforced plastics) laminates because the layup of composite laminates influences their properties. Ultrasonic NDE of composite laminates is often based on the backwall echoes of the sample. A pair of such transducers was mounted in a holder in a nose-to-nose fashion to be used as a scanning probe on composites. Miniature potted angle beam transducers were used ( Rayleigh waves in steel) on solid laminates of composites. Experiments were performed to understand the behavior of the transducers and the nature of the waves generated in the composite (mode, wave speed, angle of refraction). C-scan images of flaws and impact damage were then produced by combining the pitch-catch probe with a portable manual scanner known as the Generic Scanner (”GenScan”). The pitch-catch signal was found to be more sensitive than normal incidence backwall echo of longitudinal wave to fiber orientation of the CFRP composites, including low level porosity, ply waviness, and cracks. Therefore, it is found that the experimentally Rayleigh wave variation of pitch-catch ultrasonic signal was consistent with numerical results and one-side ultrasonic measurement might be very useful to detect the defects.
Transforming growth factor(beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly. (1999)

The data suggest that TGFbeta-mediated alpha-SMA gene expression leading to myofibroblast transformation may involve an RGD-dependent phosphotyrosine signal transduction pathway.