gebhart/patrepeval huggingface dataset:
Endovascular proximal control of ruptured abdominal aortic aneurysms: the internal aortic clamp. (2009)

Ruptured abdominal aortic aneurysm (RAAA) is the most common and devastating complication affecting a patient with abdominal aortic aneurysm (AAA). Despite advances in surgery and critical care, the mortality rate associated with RAAA remains largely unchanged. Emergency open repair is the gold standard conventional treatment of RAAA but is associated with a high mortality rate. The physiologic challenges associated with general anaesthetic induction such as loss of the sympathetic vasoconstrictor tone with consequent hypotension, and the anatomic challenges associated with external aortic cross-clamping such as calcification, friability, or poor visualisation of the aneurysm neck, have led to the adoption of endovascular techniques in the surgical treatment of RAAA. Promising results of endovascular repair of ruptured abdominal aortic aneurysm (REVAR) have been reported. In addition, the provision of endovascular aortic control by inflating a compliant aortic occlusion balloon (AOB) proximal to the ruptured aneurysm, as an internal aortic clamp, has been successfully used in haemodynamically unstable patients undergoing either REVAR or emergency open repair of RAAA. An AOB is inserted under local anaesthesia and can be introduced through either the transbrachial or the transfemoral routes, each with its own advantages and disadvantages. This review aimed at providing an up-to-date overview of the current knowledge concerning endovascular proximal aortic control using an AOB with emphasis on the rationale, position, benefits, and drawbacks of its use.
Hybrid NVM Enabled Datacenter Design and Optimization (2017)

Emerging non-volatile memories (NVMs) like battery-backed DRAM and phase-change memory offer durability at higher speeds than traditional storage. Each technology represents a different point in the cost, performance and endurance space. In this paper, we propose that storage intensive applications use more than one kind of NVM in configurable proportions to strike a balance between cost, performance and endurance. Furthermore, in virtualized environments, we show that a fixed ratio of different NVMs across co-located applications may not be ideal. We propose a new resource allocation and scheduling algorithm to enable cloud providers to help co-located applications use different proportions of NVM while meeting latency and capacity requirements. We evaluate the proposed design by simulating several storage intensive workloads and demonstrate average cost savings of 33% for cloud providers while degrading performance by only 4% and not violating any service-level agreements. Compared to conventional scheduling algorithms, the proposed scheduling algorithm reduces a cloud provider’s penalty cost and operation cost by more than 20%, 50%, and 50% at low, medium, and high server loads.
Birkeland (Harris), 'Ani und 'Ānāw in den Psalmen, aus dem Norwegischen Manuskript ins Deutsche übertragen von DT Eugen Ludwig Rapp, 1933 (1936)

Jacob Edmond. Birkeland (Harris), 'Ani und 'Ānāw in den Psalmen, aus dem Norwegischen Manuskript ins Deutsche übertragen von DT Eugen Ludwig Rapp, 1933. In: Revue d'histoire et de philosophie religieuses, 16e année n°6, Novembre-décembre 1936. pp. 523-524.
The Application of the Electron Tube to Potentiometric Titrations (1927)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Application of the Electron Tube to Potentiometric TitrationsJ. W. WilliamsJ. W. WilliamsMore by J. W. Williams and T. A WhitenackT. A WhitenackMore by T. A WhitenackCite this: J. Phys. Chem. 1927, 31, 4, 519–524Publication Date (Print):April 1, 1927Publication History Published online1 May 2002Published inissue 1 April 1927https://doi.org/10.1021/j150274a004RIGHTS & PERMISSIONSArticle Views12Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (255 KB) Get e-Alerts
Advances in 99mTc-Labeling of Antibodies (1987)

Several methods have been developed to label antibodies with 99mTc. Direct labeling results in 99mTc binding to multiple sites of various affinities that are often weaker than the binding to strong chelating agents. Attempts to overcome this disadvantage involve conjugation of strong chelating agents to the antibodies. While stability is usually enhanced, this approach suffers from alteration of antibody properties as well as non-specific binding of 99mTc to the antibody instead of to the conjugated chelating agent. This has been of concern for studies with DTPA as the chelating agent. In this study the loss of 99mTc by N2S2 challenge shows that a fraction of the 99mTc is nonspecifically bound to the antibody. An advantage of the approach of labeling antibodies containing a bifunctional chelating agent is the simplicity of the labeling procedure and the apparent high yields that in reality are the sum of chelating agent and non-specifically bound radioactivity. The last approach described in our work of conjugation of a preformed chelate has advantages of characterizable 99mTc complex chemistry and conjugation by standard protein derivatiza- tion chemistry. Slow chelation kinetics can be overcome in the small molecule stage and then conjugation performed under mild conditions with respect to the antibody or fragments. This approach, however, suffers from greater complexity of the labeling process including multiple steps, purifications and non-quantitative yields. The use of ligands for 99mTc in which the complexes are of high stability and predictable chemistry is likely to result in eventual optima labeling technologies. Processes which are non-specific may work in some cases, but are likely to present difficulties in optimization and general applicability from antibody to antibody.
In vitro and in vivo properties of novel nucleoside transport inhibitors with improved pharmacological properties that potentiate antifolate activity. (2001)

The activity of antimetabolite inhibitors of de novo deoxyribonucleotide biosynthesis can be compromised by the salvage of extracellular preformed nucleosides and nucleobases. Dipyridamole (DP) is a nucleoside transport inhibitor that has been used clinically in an attempt to increase antimetabolite activity; however, DP binds tightly to the serum protein alpha1-acid glycoprotein (AGP) thereby rendering this therapeutic strategy largely ineffective. Four novel DP analogues (NU3076, NU3084, NU3108, and NU3121) have been developed with substitutions at the 2,6- and 4,8-positions of the pyrimidopyrimidine ring. The novel DP analogues inhibit thymidine (dThd) uptake into L1210 cells in vitro (NU3076 IC(50), 0.25 microM; NU3084 IC(50), 0.27 microM; NU3108 IC(50), 0.31 microM; NU3121 IC(50), 0.26 microM; and DP IC(50), 0.37 microM), but, unlike DP, their activity remains largely unaffected in the presence of 5 mg/ml AGP. The four DP analogues inhibit dThd and hypoxanthine rescue from Alimta (multitargeted antifolate)-induced growth inhibition in A549 and COR L23 human lung carcinoma cell lines in the presence of 2.5 mg/ml AGP, whereas the activity of DP is completely abolished. i.p. administration of 10 mg/kg NU3108, NU3121, and DP produced peak plasma concentrations of 4.4, 2.1, and 6.7 microM, respectively, and levels were sustained above 1 microM for approximately 45 min (DP) and 120 min (NU3108 and NU3121). [3H]thymidine incorporation into COR L23 xenografts grown in CD1 nude mice was reduced by 64% (NU3108), 44% (NU3121), and 65% (DP) 2 h after administration of the nucleoside transport inhibitors. In conclusion, two novel DP analogues (NU3108 and NU3121) have been identified that do not bind to AGP and that display superior pharmacokinetic profiles in comparison to DP and inhibit [3H]thymidine incorporation into human tumor xenografts in vivo.
Structure and metal-binding properties of lipopolysaccharides from heptoseless mutants of Escherichia coli studied by 13C and 31P nuclear magnetic resonance. (1983)

The structure and metal-binding properties of lipopolysaccharides (LPS) from heptoseless mutants of Escherichia coli were studied by 13C and 31P NMR techniques. Carbon-13 NMR spectra were used to determine the linkages and configurations of the saccharide backbone and the types and locations of fatty acyl groups in E. coli LPS. Resonance assignments for native LPS were made by chemical shift correlation with model compounds, deacylated LPS, lipid A, deacylated lipid A, and fatty acids released from LPS by mild alkaline hydrolysis. The 3-deoxy-D-manno-octulosonate (KDO) disaccharide was tentatively assigned the structure KDO alpha 2 leads to 5KDO alpha 2 leads to. The presence of amide- and ester-linked 3-hydroxy and 3-acyloxy fatty acids in native LPS was confirmed directly from the 13C spectrum and evidence is presented for a labile acyl ester at C-3' (GlcNII) of the lipid A moiety. A significant finding was that the KDO disaccharide is linked to the C-6' position of the lipid A moiety, rather than C-3', as previously reported. The effects of binding Ca2+, Cd2+, Yb3+, Gd3+, and La3+ on the 31P NMR spectrum of LPS indicated that the glycosidic diphosphate moiety participates in a high affinity metal-binding site.
An isoleucyl-tRNA synthetase gene from Campylobacter jejuni (1995)

A complete isoleucyl-tRNA synthetase gene (ileS) of Campylobacter jejuni was isolated from a C. jejuni TGH9011 genomic DNA library constructed in pBluescript. The complete coding sequence, flanking regions and transcription start point were determined. The deduced isoleucyl-tRNA synthetase (IleRS) had 917 amino acids with a molecular mass of 105,399 Da, which was consistent with the observed size of 105 kDa in Escherichia coli maxicells. The ileS gene was mapped onto the physical map of the C. jejuni genome. Alignment of the C. jejuni IleRS sequence with six other bacterial IleRS sequences and two lower eukaryotic IleRS sequences identified seven conserved motifs, including the two signature sequences, HIGH and KMSKS, of class I aminoacyl-tRNA synthetases.
Factors influencing the formation of a user's perceptions and use of a DSS software innovation (2001)

Understanding how users form perceptions of a software innovation would help software designers, implementers and users in their evaluation, selection, implementation and on-going use of software. However, with the exception of some recent work, there is little research examining how a user forms his or her perceptions of an innovation over time. To address this research need, we report on the experiences of a health planner using a DSS software tool for health planning over a 12-month period. Using diffusion theory as outlined by Rogers, we interpret the user's perceptions of the software following Rogers' perceived characteristics of the innovation. Furthermore, we show how our user justifies her attitudes toward the technology using 5 important factors during 3-, 6- and 12-month interviews: stage of adoption, implementation processes, organizational factors, subjective norms, and user competence. Results are compared with key IS research in these areas, and the implications of these findings on the diffusion of decision support systems are discussed.
Inverted top-emitting organic light-emitting devices with an effective cathode structure (2004)

In this paper, we report an effective bottom cathode structure for enhancing the electron injection in inverted top-emitting OLEDs. Such a cathode structure does not involve handling reactive metals during fabrication and permits use of highly reflective materials such as Al and Ag as the bottom cathode.
Voltammetric studies of the interaction of tris(1,10-phenanthroline)cobalt(III) with DNA (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVoltammetric studies of the interaction of tris(1,10-phenanthroline)cobalt(III) with DNAMichael T. Carter and Allen J. BardCite this: J. Am. Chem. Soc. 1987, 109, 24, 7528–7530Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/ja00258a046https://doi.org/10.1021/ja00258a046research-articleACS PublicationsRequest reuse permissionsArticle Views1127Altmetric-Citations307LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of continuous high dose rhgm‐csf infusion on human monocyte activity (1993)

In this study we describe the time-dependent effects of a high dose (750 micrograms/ml/24 hr) continuous infusion of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on monocyte number, cytokine release, and superoxide anion production. Blood was taken from patients prior to rhGM-CSF infusion (day 0), and on days 1, 7, and 14 of infusion. The mean concentration of monocytes per ml of blood increased progressively from 4.3 x 10(5) on day 0 to 21 x 10(5) on day 14 of infusion. There was no significant change in the basal release of tumor necrosis factor alpha (TNF-alpha) or interleukin 1 beta (IL-1 beta) induced by rhGM-CSF. However, the lipopolysaccharide (LPS)-stimulated release of TNF-alpha by monocytes increased significantly on day 1 of infusion, and by day 14 had increased 8-fold. IL-1 beta release from LPS-stimulated monocytes increased slightly by day 7, and by almost 10-fold by day 14 of infusion. When maximally stimulated with phorbol dibutyrate, the monocytes demonstrated an increased (although not significant) capacity to produce superoxide anion on days 7 and 14 of infusion. No change in basal superoxide anion production was seen at any day of infusion. These GM-CSF-induced changes in stimulated cytokine and superoxide anion release could not be reproduced by treating monocytes with rhGM-CSF in vitro. In summary, a two week, high dose infusion of rhGM-CSF resulted in increases in circulating monocyte concentration, and in the stimulated release of TNF-alpha and IL-1 beta, and superoxide anion production from these monocytes. These primed monocytes could enhance the ability of neutropenic patients to fight infection.
Wideband FM Generation (1968)

An analysis is presented which demonstrates that an exact FM signal with no theoretical limits on its frequency deviation or modulation frequency may be obtained by wave shaping an FM triangular wave. A straightforward method of physically generating the FM triangular wave along with experimental data on the resultant circuit is also presented. These data indicate that for frequency deviations as high as 75 percent of the carrier frequency, overall transmitter-receiver system distortions are of the order of 0.2 percent.
DEWS: A Live Visual Surveillance System for Early Drowning Detection at Pool (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A real-time vision system operating at an outdoor swimming pool is presented in this paper. The system is designed to automatically recognize different swimming activities and to detect occurrence of early drowning incidents. We have named this system the Drowning Early Warning System (DEWS). One key challenge we faced in the problem is the relatively high level of noise in the steps of foreground detection and behavior recognition. Therefore, a set of methods in the fields of background subtraction, denoising, data fusion and blob splitting are proposed, which have been motivated by characteristics of aquatic background and crowded scenario at the pool. In the step to detect an early drowning incident, visual indicators of distress and drowning are incorporated through a set of foreground descriptors. A module comprising data fusion and hidden Markov modeling is developed to learn unique traits of different swimming behaviors, in particular, those early drowning events. The experiment of this work reports realistic on-site evaluations performed. Examples of interesting behaviors, i.e., distress, drowning, treading and numerous swimming styles, are simulated and collected. Experimental results show that we have established a prototype system which is robust and beyond the stage of proof-of-concept. </para>
Low noise-low power digital phase-locked loop (2010)

We propose a phase-locked loop (PLL) architecture, which reduces the double frequency ripple without increasing the order of loop filter. Proposed architecture uses quadrature numerically-controlled oscillator (NCO) to provide two output signals with phase difference of π/2. One of them is subtracted from the input signal before multiplying with the other output of NCO. The system also provides stability in case the input signal has noise in amplitude or phase. The proposed structure is implemented using field programmable gate array (FPGA), which dissipates 15.44 mW and works at clock frequency of 155.8 MHz.
Photoaffinity labeling of DNA polymerase α DNA primase complex based on the catalytic competence of a dNTP reactive analog (1992)

FABdCTP was found to be a substrate of DNA polymerization catalyzed by a DNA polymerase alpha-DNA primase complex on the 5'-GTGAGTAAGTGGAGTTTGGCACGAT-3' template and 3'-CTCAAACCGT-5' primer. After complete primer extension in the presence of FABdCTP under UV-irradiation of the reaction mixture, 70% of the template was covalently linked to the primer. Labeling of the 165 kDa subunit of the DNA polymerase alpha, 59 kDa and 49 kDa subunits of the DNA primase and an unknown protein with apparent molecular weight of 31 kDa was observed. By another way of protein labeling FABdCTP was covalently bound to the subunits of the enzyme under UV irradiation and then this moiety was introduced into the 3'-end of the 5'-[32P]primer by the catalytic activity of DNA polymerase or DNA primase. In this case covalent labeling of the 165 kDa, 49 kDa and 31 kDa subunits was observed.
Sonochemical functionalization of mesoporous carbon for uranium extraction from seawater (2012)

Extracting uranium from seawater is challenging due to its low concentration (3.3 ppb) and the myriad of competing ions. Mesoporous carbon materials provide a high surface area alternative to the traditional polymeric fiber braids developed for seawater extractions, specifically uranium extraction. In this work, sonochemical grafting of acrylonitrile onto the pores of soft-templated mesoporous carbons followed by its conversion to amidoxime functionalities was used to prepare an effective sorbent material with a high density of binding sites. Pore blockage, often observed for free radical polymerization, leads to poor adsorbent performance but can be easily overcome by the use of ultrasound during polymerization. Parameters such as surface area and surface pre-treatment, sonication intensity, solvent system, and monomer/initiator ratios were varied to optimize the polymerization and uranium adsorption capacity while not blocking the porosity, a significant hurdle in the utilization of functionalized porous materials. The results show that neither the surface oxidation with nitric acid nor CO2 activation alone is sufficient to cause significant improvement in grafting and uranium uptake. However, when coupled together, a greatly enhanced performance of the adsorbent materials was observed.
Changes on computed cranial tomography with aging: intracranial fluid volume. (1982)

A semiautomated computer analysis was developed to estimate fluid volumes in each hemicranium from computed tomography scans. The method was used to estimate total ventricular and sulcal fluid in 123 normal subjects aged 23-88 years. A wide range of normal values was found. The trend was for the estimated ventricular and sulcal fluid volumes to remain relatively constant until age 60 and then to increase at an increasing rate thereafter. Ventricular enlargement occurred in the absence of sulcal enlargement and vice versa. The estimate of the volume of the ventricles was related to skull size. When this was taken into account, the size of the ventricles showed no sex difference. The cranial cavity was larger in men than in women, and, in both genders, the left hemicranium and the left ventricle were larger on the average than their right counterparts. The limitations of computed cranial tomography as a quantitative tool are discussed in detail.
Multiple bandpass filters in image processing (1980)

A system of bandpass filters, modelled on the early mechanisms of human vision, is described which provides a simple means to eliminate blur and noise from an image. The system automatically adjusts itself to suit local signal conditions in an image, without prior knowledge of signal statistics.
Characterization of an Avian Infectious Bronchitis Virus Isolated in China from Chickens with Nephritis (2004)

One IBV isolate, SC021202, was isolated from the kidneys of the infected young chickens by inoculating embryonated eggs, and its morphology, physiochemical and haemagglutonating properties were detected. Virulence of the isolate SC021202 was determined with specific pathogen-free (SPF) chicken inoculation. Nucleotide acid sequence of S1 gene of the isolate SC021202 was further sequenced and analysed. The physiochemical and morphological properties of the isolate SC021202 were in accordance to that of typical infectious bronchitis virus (IBV). In a pathogenicity experiment, the clinical signs and related gross lesions resembling those of field outbreak were reproduced and the virus isolate SC021202 was re-isolated from the kidneys of the infected chicken. Sequence data demonstrated that the full length of the amplified S1 gene of the isolate SC021202 was composed of 1931 nucleotides, coding a polypeptide of 543 amino acid residues. Compared with IBV strains from GenBank, the nucleotide and deduced amino acid sequence of S1 gene of the isolate SC021202 shared 60.0-91.4% and 49.1-88.9% identities, respectively. A nucleotide fragment of 'CTTTTTAATTATACTAACGGA' was inserted at nucleotide site 208 in the S1 gene of the isolate. These results indicated that IBV isolate SC021202 was a new variant IBV isolate and responsible for field outbreak of nephritis.