gebhart/patrepeval huggingface dataset:
Simvastatin Release from Poly(lactide-co-glycolide) Membrane Scaffolds (2010)

Statins, a group of potent inhibitors of 3-hydroxy-3-methylglutaryl Coenzyme A reductase in cholesterol biosynthesis pathway, have been widely used as a cholesterol lowering drug. The plieotrophic effect of statins on bone metabolism in long-term usage has been begun to be studied during recent years and several in vitro and in vivo studies have demonstrated the ability of statins to promote expression of bone morphogenetic protein-2 (BMP-2), inhibition of osteoclast differentiation and reduction of osteoporotic fractures risk. The high liver specificity and low oral bioavailability of statins, leading to poor peripheral distribution, are the main obstacles to benefit anabolic effects of hydrophobic statins on bone formation. Therefore, developing new administration roots for direct delivery to achieve optimum concentration in the bone microenvironment is of interest. Here we present and compare two approaches of combining statins with bone tissue engineering scaffolds. Simvastatin was combined with a poly(lactide-co-glycolide) (PLGA) membrane scaffold for diffusion-controlled release by dissolving simvastatin (dis-sim) in the membrane casting dope, and for degradation-controlled release by covalently bonding saponifiedsimvastatin (sap-sim) to the PLGA in the spinning dope. Rheological and concentration-dependent membrane morphology changes were observed with saponifiedsimvastatin, suggesting ester bond cleavage and covalent bonding of the statin to the PLGA, but not with dissolved simvastatin. Dissolved simvastatin membranes showed a logarithmic decay release profile while the saponifiedsimvastatin membranes showed constant release. It can be concluded that the covalent bonding of simvastatinto PLGA scaffolds is showing potential for use as a controlled releasescaffold for bone tissue engineering.
Residual Symptoms in Depressed Patients Who Respond Acutely to Fluoxetine (1999)

Less than 20% of full responders to fluoxetine by HAM-D criteria were free of all SCID-P subthreshold and threshold major depressive disorder symptoms after 8 weeks of treatment. While depressed patients benefit from antidepressants, most continue to have some symptoms of depression. The high prevalence of residual symptoms among antidepressant responders suggests the need for further study including whether residual symptoms abate with longer treatment or increased dose of fluoxetine. Other strategies, such as cognitive behavioral therapy, may be needed to address residual symptoms.
Cannabis and cancer chemotherapy. A comparison of oral delta-9-thc and prochlorperazine (1982)

Delta-9-tetrahydrocannabinol (THC) and prochlorperazine (Compazine) were found to be equally efficacious in reducing nausea and vomiting associated with cancer chemotherapy across a wide range of chemotherapeutic regimens and tumor types. Both drugs were administered orally one hour before chemotherapy, then every four hours for a total of four doses. Compazine was administered in a fixed dose of 10 mg; THC was administered by body surface area (BSA): BSA less than 1.4 m2 = 7.5 mg; BSA 1.4-1.8 m2 = 10- mg; and BSA greater than 1.8 m2 = 12.5 mg. Two hundred and fourteen subjects (75% of whom had previously received Compazine with varying results) were evaluated employing a double-blind, crossover design. Additional parameters evaluated were study drug effects on appetite, food intake, mood, activity, relaxation, interaction, and concentration. There were significant drug effects with THC: less ability to concentrate (P less than 0.01), less social interaction (P less than 0.05), and less activity (P less than 0.05). There were no significant differences between the two drugs in the level of food intake or appetite. Patients of all ages did equally well on both drugs. Neither past marijuana use nor past Compazine use were related to study the drug efficacy. Those patients who correctly identified their THC cycle did better on THC versus those who could not correctly identify which antiemetic they had received (P less than 0.05). There were more drug-related effects associated with THC, but these did not reduce the patients' preference for the drug, and were associated with nausea reduction (P less than 0.05).
Equiform kinematics and the geometry of line elements. (2006)

Abstract. The present paper studies Plücker coordinates for line elements in Euclidean three-space. The well known relation between line geometry and kinematics is generalized to equiform motions and the geometry of line elements. We consider bundles and linear complexes of line elements and survey their properties.
Seed Characteristics and Seedling Emergence of Dalmatian Toadflax (1970)

In eastern Washington Dalmatian toadflax ( Linaria dalmatica (L.) Mill) produces seeds for about 3 months, beginning in early July, with over 95% produced during the first 5 weeks. A large plant will produce a half million seeds under good conditions. Seeds are sharply angular, slightly winged, and 1 to 2 mm long. Approximately 7,000 weigh 1 g. Seeds are spread by wind and browsing animals. Some seeds will germinate under laboratory conditions the same season in which produced, but germination from dry storage increases for 2 to 3 years, with a periodic low in November and a high in April. Over 90% germination is obtained with 2 to 3-year-old seeds in the laboratory. Germination in the field occurs in both spring and fall, and seedlings can emerge from a soil depth of 2 to 2.5 cm.
Composites of Graphene Nanoribbon Stacks and Epoxy for Joule Heating and Deicing of Surfaces (2016)

A conductive composite of graphene nanoribbon (GNR) stacks and epoxy is fabricated. The epoxy is filled with the GNR stacks, which serve as a conductive additive. The GNR stacks are on average 30 nm thick, 250 nm wide, and 30 μm long. The GNR-filled epoxy composite exhibits a conductivity >100 S/m at 5 wt % GNR content. This permits application of the GNR-epoxy composite for deicing of surfaces through Joule (voltage-induced) heating generated by the voltage across the composite. A power density of 0.5 W/cm(2) was delivered to remove ∼1 cm-thick (14 g) monolith of ice from a static helicopter rotor blade surface in a -20 °C environment.
ZVS for PT Backlight Inverter Utilizing High-Order Current Harmonic (2008)

A zero-voltage-switching (ZVS) method utilizing high-order current harmonics for piezoelectric transformer (PT) backlight inverter is presented. In order to enhance the efficiency of PT backlight inverter, a large inductor is usually connected in series with PT for ZVS and filtering. Utilizing high-order current harmonics for ZVS can greatly reduce the required series inductance. The ZVS condition of the proposed approach is analyzed, and related experimental waveforms are shown. This method also minimizes the delay introduced into the inverter control loop, and makes the designs between ZVS and control loop independent. Measured power conversion efficiency of the tested PT backlight inverter is 85%.
Comparison of first order PMD compensation techniques (2004)

In this paper we present BER measurement results using a 1/sup st/ order compensator with a fixed and a variable delay line and compare with the PSP transmission method. For the fixed delay line we tested compensation efficiency for different DGD values. PSP transmission method was evaluated for different feedback delay times. A PMD emulator forced by pseudo-random fluctuations of temperature was used to generate a random set of PMD vectors. A comparison between the different methods is presented.
Enhancing patent retrieval by citation analysis (2007)

This paper proposes a method to combine text-based and citation-based retrieval methods in the invalidity patent search. Using the NTCIR-6 test collection including eight years of USPTO patents, we show the effectiveness of our method experimentally.
Compression of Laplacian Pyramids through Orthogonal Transforms and Improved Predictions (2008)

International audience
Glucose-Dependent Insulinotropic Polypeptide Augments Glucagon Responses to Hypoglycemia in Type 1 Diabetes (2014)

Glucose-dependent insulinotropic polypeptide (GIP) is glucagonotropic, and glucagon-like peptide-1 (GLP-1) is glucagonostatic. We studied the effects of GIP and GLP-1 on glucagon responses to insulin-induced hypoglycemia in patients with type 1 diabetes mellitus (T1DM). Ten male subjects with T1DM (C-peptide negative, age [mean ± SEM] 26 ± 1 years, BMI 24 ± 0.5 kg/m(2), HbA1c 7.3 ± 0.2%) were studied in a randomized, double-blinded, crossover study, with 2-h intravenous administration of saline, GIP, or GLP-1. The first hour, plasma glucose was lowered by insulin infusion, and the second hour constituted a "recovery phase." During the recovery phase, GIP infusions elicited larger glucagon responses (164 ± 50 [GIP] vs. 23 ± 25 [GLP-1] vs. 17 ± 46 [saline] min ⋅ pmol/L, P < 0.03) and endogenous glucose production was higher with GIP and lower with GLP-1 compared with saline (P < 0.02). On the GIP days, significantly less exogenous glucose was needed to keep plasma glucose above 2 mmol/L (155 ± 36 [GIP] vs. 232 ± 40 [GLP-1] vs. 212 ± 56 [saline] mg ⋅ kg(-1), P < 0.05). Levels of insulin, cortisol, growth hormone, and noradrenaline, as well as hypoglycemic symptoms and cognitive function, were similar on all days. Our results suggest that during hypoglycemia in patients with T1DM, exogenous GIP increases glucagon responses during the recovery phase after hypoglycemia and reduces the need for glucose administration.
CrowdPlanner: A crowd-based route recommendation system (2014)

As travel is taking more significant part in our life, route recommendation service becomes a big business and attracts many major players in IT industry. Given a pair of user-specified origin and destination, a route recommendation service aims to provide users with the routes of best travelling experience according to criteria, such as travelling distance, travelling time, traffic condition, etc. However, previous research shows that even the routes recommended by the big-thumb service providers can deviate significantly from the routes travelled by experienced drivers. It means travellers' preferences on route selection are influenced by many latent and dynamic factors that are hard to model exactly with pre-defined formulas. In this work we approach this challenging problem with a very different perspective- leveraging crowds' knowledge to improve the recommendation quality. In this light, CrowdPlanner - a novel crowd-based route recommendation system has been developed, which requests human workers to evaluate candidate routes recommended by different sources and methods, and determine the best route based on their feedbacks. In this paper, we particularly focus on two important issues that affect system performance significantly: (1) how to efficiently generate tasks which are simple to answer but possess sufficient information to derive user-preferred routes; and (2) how to quickly identify a set of appropriate domain experts to answer the questions timely and accurately. Specifically, the task generation component in our system generates a series of informative and concise questions with optimized ordering for a given candidate route set so that workers feel comfortable and easy to answer. In addition, the worker selection component utilizes a set of selection criteria and an efficient algorithm to find the most eligible workers to answer the questions with high accuracy. A prototype system has been deployed to many voluntary mobile clients and extensive tests on real-scenario queries have shown the superiority of CrowdPlanner in comparison with the results given by map services and popular route mining algorithms.
CYTOGENETICS OF FLOWER MODIFICATION OF A CYTOPLASMIC MALE-STERILE TOBACCO (1980)

Plants combining the cytoplasm of Nicotiana debneyi and the 48 chromosomes from N. tabacum are male sterile. Early backcross generations of the amphidiploid hybrid to male N. tabacum produced a great variety of plants from which a series of phenotypes with characteristic flower forms and transmission rates have been isolated. Type 1A possesses completely feminized stamens and deeply split corollas, breeds true when backcrossed to normal males and carries 48 N. tabacum chromosomes. Other phenotypes, 2C, 3E and 4H, range toward normal morphology of corollas and stamens. Like 1A, 2C forms no anther tissue and has 48 chromosomes. This type is transmitted to 36.3% of the backcross progeny, the remainder being of type 1A; presumably 2C carries a chromosome segment from N. debneyi that is responsible for the partial restoration of flower structure. In contrast, both 3E and 4H produce anthers and possess an extra chromosome. The extra chromosomes are transmitted to only 19.9% and 7.1% of the progeny, respectively. Significantly, the extra chromosomes found in the anther-forming types are nucleolus organizing and carry a satellite from N. debneyi. On the basis of these observations, we surmise that differentiation of anthers in plants with N. debneyi cytoplasm may depend on the presence of a nucleolus-organizing chromosome from that species. This chromosome is unstable; unaltered, it conditions a highly restored phenotype (4H), but when structurally modified, it may control different phenotypic expressions. Other examples of satellited restorer chromosomes had been reported for different cytoplasmically male-sterile combinations; therefore, the phenomenon may have more general significance.
Section 1. The Australian insecticide resistance management strategy (1993)

Summary In response to field pyrethroid failures against Helicoverpa armigera (Hübner) in early 1983, an insecticide resistance management (IRM) strategy was introduced for insect control in summer crops in eastern Australia. The aims of this strategy were to contain the pyrethroid resistance problem, to prevent re-selection of historical endosulfan resistance (both curative IRM) and to avoid any future problems with organophosphate/carbamate resistance (preventative IRM). An alternation strategy was adopted which was based on the rotation of unrelated chemical groups on a per generation basis, along with a strong recommendation for the use of ovicidal mixtures. These chemical countermeasures were then integrated with other non-chemical control methods (biological and cultural) into a workable integrated pest management programme. The restrictions were applied to all Helicoverpa armigera susceptible crops (including cereals, oilseeds, grain legumes, tomatoes, tobacco and cotton) and even to other co-incident pest species. From its inception, compliance with the voluntary strategy has been exceptional.
Changes in seismic velocity and attenuation during deformation of granite (1977)

The seismic velocity and attenuation were measured for P, S⊥, and S∥ waves traveling through a sample of Westerley Granite as it was deformed to failure under a confining pressure of 500 bars. All waves traveled in a direction normal to the axis of maximum compression, with S∥ polarized parallel to the axis and S⊥ polarized normal to it. By the time failure occurred, all seismic velocities had decreased by 12–30%. Amplitudes of the S⊥ and P waves decreased by approximately 30%. A remarkable result of the experiment is that the amplitude of the S∥, wave increased throughout the experiment until near failure. The amplitude at 90% failure strength was more than twice the value under hydrostatic pressure alone. These results are explained by analyzing how elastic moduli and energy dissipation due to frictional sliding at cracks are affected by anisotropic crack distribution developed in the sample as axial stress is applied.
Complete primary structure and functional characterization of the sixth component of the human complement system (1989)

Complement C6 is one of five plasma proteins that are incorporated into the lytic terminal complement complex on lipid membranes (C5b-9m) upon activation of the complement cascade. Oligonucleotide probes derived from partial amino acid sequences of purified C6 were used to isolate cDNA clones from a human liver cDNA library. The complete polypeptide structure of mature C6 deduced from the cDNA sequence consists of 913 amino acid residues preceded by a typical 21-residue signal peptide. C6 is most similar in structure to complement C7, sharing 33.5% identical residues with C7 including all 56 cysteine residues. The low density lipoprotein receptor class A and B modules, the thrombospondin type I module at the carboxyl terminus, and the two short consensus repeat modules are arranged in the same way as in C7. In contrast to C7 and other terminal complement proteins, the thrombospondin type I module at the amino terminus occurs as a tandem repeat in C6. The last tandem repeat at the carboxyl terminus of C6 and C7 has been identified as a new distinct module (factor I module), which is closely related to a segment in the heavy chain of complement control factor I. Binding studies with filter-bound C6 fragments generated by proteolysis showed that the C5b-binding domain of C6 was located in the 34-kDa carboxyl terminal fragment consisting of two short consensus repeats and two factor I modules.
Representation is representation of similarities (1998)

Advanced perceptual systems are faced with the problem of securing a principled (ideally, veridical) relationship between the world and its internal representation. I propose a unified approach to visual representation, addressing the need for superordinate and basic-level categorization and for the identification of specific instances of familiar categories. According to the proposed theory, a shape is represented internally by the responses of a small number of tuned modules, each broadly selective for some reference shape, whose similarity to the stimulus it measures. This amounts to embedding the stimulus in a low-dimensional proximal shape space spanned by the outputs of the active modules. This shape space supports representations of distal shape similarities that are veridical as Shepard's (1968) second-order isomorphisms (i.e., correspondence between distal and proximal similarities among shapes, rather than between distal shapes and their proximal representations). Representation in terms of similarities to reference shapes supports processing (e.g., discrimination) of shapes that are radically different from the reference ones, without the need for the computationally problematic decomposition into parts required by other theories. Furthermore, a general expression for similarity between two stimuli, based on comparisons to reference shapes, can be used to derive models of perceived similarity ranging from continuous, symmetric, and hierarchical ones, as in multidimensional scaling (Shepard 1980), to discrete and nonhierarchical ones, as in the general contrast models (Shepard & Arabie 1979; Tversky 1977).
Detection of a secreted form of the murine H-2 class I antigen with an antibody against its predicted carboxyl terminus. (1984)

Analysis of H-2 class I-specific cDNA clones has suggested the synthesis by the liver of a class I molecule that is secreted rather than membrane bound. To detect this putative class I-related molecule, we have predicted a unique region of amino acid sequence located toward the carboxyl terminus of the molecule that is not expected to be shared with any of the classical H-2 class I antigens, and we have generated specific antibodies to a synthetic peptide corresponding to this sequence. Indirect immunoprecipitation with this antibody led to the identification of a Mr 40,000 polypeptide in association with beta 2-microglobulin in the serum of mice of five different H-2 haplotypes. This class I molecule is also detected in the liver together with lower molecular weight components, which are presumably underglycosylated precursors. Synthesis of this molecule is not detected in thymus, spleen, kidney, or testis. This class I serum component has no detectable reactivity with either a broad-specificity alloantiserum against H-2b or a xenoantiserum against purified H-2a class I molecules. The availability of a specific antibody against the secreted class I molecule offers a means to purify this protein for structural and functional studies.
A new and specific method for the protection of phenols as the corresponding tert-butyl ethers (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new and specific method for the protection of phenols as the corresponding tert-butyl ethersJulie Lynn Holcombe and Tom LivinghouseCite this: J. Org. Chem. 1986, 51, 1, 111–113Publication Date (Print):January 1, 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://pubs.acs.org/doi/10.1021/jo00351a028https://doi.org/10.1021/jo00351a028research-articleACS PublicationsRequest reuse permissionsArticle Views1303Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fluorescence Resonance Energy Transfer Glucose Sensor from Site-Specific Dual Labeling of Glucose/Galactose Binding Protein Using Ligand Protection (2012)

The ligand protection strategy provides a simple method for labeling GGBP with two different fluorophores to construct FRET-based glucose sensors with glucose affinity within the human physiological glucose range (1-30 mM). This general strategy may also have broad utility for other protein-labeling applications.
High-reliability silicon microchannel submount for high average power laser diode arrays (1990)

A simple and highly reliable package consisting of a 1-cm-long AlGaAs laser diode array mounted directly on a silicon microchannel cooler has been demonstrated. 3.4×109 shots were logged on this device at an average optical output of 8.75 W with only a 6% increase in current required to hold the light output constant. This extrapolates to a current doubling lifetime of 1.6×1011 shots. The thermal impedance was also measured to be 0.014 °C/(W/cm2).
Ca2+/Calmodulin-Dependent Protein Kinase II Equally Induces Sarcoplasmic Reticulum Ca2+ Leak in Human Ischaemic and Dilated Cardiomyopathy (2014)

Functional and molecular measures of the SR Ca(2+) leak are comparable in human ICM and DCM. CaMKII is equally responsible for the induction of the 'RyR2 leakiness' in both pathologies. Thus, CaMKII inhibition as a therapeutic measure may not be restricted to patients suffering from DCM but rather may be beneficial for the majority of HF patients.
Stereoselektive Synthese von (<i>E</i>)‐4‐Hydroxy‐2‐alkensäureestern aus Aldehyden und dem d<sup>3</sup>‐Baustein Lithiopropiolsäure‐ethylester (1984)

Für die in Naturstoffen weitverbreitete ( E )‐4‐Hydroxy‐2‐alkensäureester‐Teilstruktur 1 wurde eine stereoselektive Synthese ausgearbeitet. Dazu wird aus einem Aldehyd und der Li‐Verbindung 2 ein 4‐funktionalisierter 2‐Alkinsäureester aufgebaut, den man E ‐stereoselektiv zu 1 reduziert. Der Anwendungsbereich kann am Aldehyd 3 demonstriert werden. magnified image