gebhart/patrepeval huggingface dataset:
Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077. (1996)

We investigated the mitochondrial toxicity of the lipophilic cation, MKT-077, and the role of mitochondria in selective malignant cell killing by this compound by examining the effect of MKT-077 on mitochondrial structure and function in treated cells and in isolated organelles. Results of this study demonstrate changes in mitochondrial ultrastructure that are induced by MKT-077 treatment in carcinoma cells but not in similarly treated normal epithelial cells. In addition, MKT-077 was found to inhibit respiratory activity in isolated intact mitochondria and electron transport activity in freeze-thawed mitochondrial membrane fragments in a dose-dependent manner. The concentration of MKT-077 necessary to obtain half-maximal inhibition of ADP-stimulated respiration was approximately 4-fold greater in mitochondria isolated from cells of the normal epithelial cell line, CV-1 (15 micrograms MKT-077/mg protein), as compared to the human colon carcinoma cell line, CX-1 (4 micrograms MKT-077/mg protein). Further, the data show a selective loss of mitochondrial DNA in CX-1 and CRL1420 cells (carcinoma) but not CV-1 cells (normal epithelial) treated with 3 microgram/ml MKT-077 for up to 3 days. Under the same conditions, nuclear DNA was unaffected in all three cell lines. The sensitivity of the cell lines tested to mitochondrial damage by MKT-077 correlates well with their sensitivity to cytotoxicity by MKT-077. These results demonstrate selective mitochondrial damage by MKT-077 at the cellular, biochemical, and molecular levels and suggest that selective effects on mitochondrial structure and function may provide a basis for the selective malignant cell killing exhibited by this compound.
Paradoxical withdrawal of reflex vasoconstriction as a cause of hemodialysis-induced hypotension. (1992)

Acute hypotension is an important complication of hemodialysis, but the underlying mechanisms remain poorly understood. Because hemorrhage-induced hypovolemia can trigger a sudden decrease in sympathetic activity resulting in bradycardia and vasodilation, we hypothesized that hemodialysis-induced hypovolemia also can trigger the same type of vasodepressor reaction, which would exacerbate the volume-dependent fall in blood pressure. We therefore measured blood pressure, vascular resistance, and sympathetic nerve activity (intraneural microelectrodes) during sessions of maintenance hemodialysis in 7 patients with and 16 patients without a history of hemodialysis-induced hypotension. During hemodialysis, blood pressure at first remained unchanged as calf resistance increased in both hypotension-resistant (from 37 +/- 4 to 49 +/- 5 U, P < 0.05) and hypotension-prone (from 42 +/- 6 to 66 +/- 12 U, P < 0.05) patients; sympathetic activity increased comparably in the subset of patients in whom it could be measured. With continued hemodialysis, calf resistance and sympathetic activity increased further in the hypotension-resistant patients, but in the hypotension-prone patients the precipitous decrease in blood pressure was accompanied by decreases in sympathetic activity, vascular resistance, and heart rate as well as symptoms of vasodepressor syncope. On an interdialysis day, both groups of patients increased vascular resistance normally during unloading of cardiopulmonary baroreceptors with lower body negative pressure and increased heart rate normally during unloading of arterial baroreceptors with infusion of nitroprusside. These findings indicate that in a group of hemodialysis patients without diabetes or other conditions known to impair autonomic reflexes, hemodialysis-induced hypotension is not caused by chronic uremic impairment in arterial or cardiopulmonary baroreflexes but rather by acute, paradoxical withdrawal of sympathetic vasoconstrictor drive producing vasodepressor syncope.
JackIn space (2017)

Traditional telepresence systems only supported first person view and users had difficulty in recognizing the surrounding situation of their remote workspace. JackIn Space is a telepresence system that solves this problem by seamlessly integrating first person view with third person view. With a head-mounted first person camera and multiple depth sensors installed in the environment, the surrogate user's first person view smoothly changes to the out-of-body third person view, and the user connected to the surrogate user can virtually look around the environment. The user can also dive into other surrogate users to gain different perspectives. Our evaluation supports that the concept and the function of JackIn Space was quite well accepted and our prototype system provides a more natural viewpoint selection. Overall, JackIn Space supports better remote collaborations.
Recognition of foreign names spoken by native speakers (2007)

It is a challenge to develop a speech recognizer that can handle the kind of lexicons encountered in an automatic attendant or car navigation application. Such lexicons can contain several 100K entries, mainly proper names. Many of these names are of a foreign origin, and native speakers can pronounce them in different ways, ranging from a completely nativized to a completely foreignized pronunciation. In this paper we propose a method that tries to deal with the observed pronunciation variability by introducing the concept of a foreignizable phoneme, and by combining standard acoustic models with a phonologically inspired back-off acoustic model. The main advantage of the approach is that it does not require any foreign phoneme models nor foreign speech data. For the recognition of English names by means of Dutch acoustic models, we obtained a reduction of the word error rate by more than 10% relative.
High-speed tomography of time-bin-entangled photons using a single-measurement setting (2012)

We generate time-bin entangled photons and measure the resulting quantum state with a tomography system that uses asymmetric interferometers having $3\ifmmode\times\else\texttimes\fi{}3$ output couplers. This configuration allows for measurements to be made simultaneously in all bases that are required for tomographic reconstruction. By eliminating the burden of tuning interferometer phases and by measuring all the spatial and temporal modes, substantial improvements in measurement speed are observed. Raw fidelities of 84$%$ with respect to an ideal entangled state are measured in about 2 s using a 12-MHz entangled state generator, with corresponding accidental count subtracted fidelities exceeding 90$%$.
Solution of the Conformation and Alignment Tensors for the Binding of Trimethoprim and Its Analogs to Dihydrofolate Reductase:  3D-Quantitative Structure−Activity Relationship Study Using Molecular Shape Analysis, 3-Way Partial Least-Squares Regression, and 3-Way Factor Analysis (1996)

Molecular recognition is the basis of rational drug design, and for this reason it has been extensively studied. However, the process by which a ligand recognizes and binds to its receptor is complex and not well understood. For the case in which the geometries (conformation and alignment) of the ligand and receptor are known from X-ray crystal structure data, the problem is simplified. The receptor-bound conformation and alignment of the ligand is assumed, and those of additional ligands are inferred. For the general case in which the geometries of the ligand(s) and receptor are unknown, no general treatment or solution is available and receptor-ligand geometries must be obtained indirectly from structure-activity studies or synthesis and evaluation of rigid analogs. A general treatment for solving for the receptor-bound geometry of a series of ligands is presented here. Using molecular shape analysis, for ligand description, tensor analysis of N-way arrays by partial least-squares (PLS) regression, and 3-way factor analysis, the receptor-bound geometries of trimethoprim and a series of trimethoprim-like dihydrofolate reductase inhibitors are correctly predicted.
Raman Spectroscopy of a Coal Liquid Shows That Fluorescence Interference Is Minimized with Ultraviolet Excitation (1984)

The first ultraviolet resonance Raman measurements of a coal liquid are reported. The spectra detail the presence of numerous polycyclic aromatic hydrocarbons with ring systems similar to those of naphthalene, fluorene, phenanthrene, pyrene, and triphenylene . The ultraviolet resonance Raman measurements of this highly complex sample show no significant interference from fluorescence. The lack of fluorescence interference and the high selectivity indicate that ultraviolet resonance Raman spectroscopy is a powerful new technique for characterizing highly complex samples and mixtures.
High speed AlGaAs/GaAs HBT circuits for up to 40 Gb/s optical communication (2002)

High speed circuits such as multiplexer/demultiplexers, variable-gain limiting amplifiers (VGAs), and transimpedance amplifiers operating at high bit rates (>30 Gb/s) are required for the realization of high performance lightwave systems using TDM or WDM. We have demonstrated 40 Gb/s multiplexers, 30 Gb/s data and clock regeneration, DC-26 GHz VGAs, and transimpedance amplifiers with 3 dB bandwidth in excess of 20 GHz for use in such systems using a manufacturable hybrid digital/microwave HBT process.
Triplex Selective 2-(2-Naphthyl)quinoline Compounds:  Origins of Affinity and New Design Principles (2003)

A novel competition dialysis assay was used to investigate the structural selectivity of a series of substituted 2-(2-naphthyl)quinoline compounds designed to target triplex DNA. The interaction of 14 compounds with 13 different nucleic acid sequences and structures was studied. A striking selectivity for the triplex structure poly dA:[poly dT](2) was found for the majority of compounds studied. Quantitative analysis of the competition dialysis binding data using newly developed metrics revealed that these compounds are among the most selective triplex-binding agents synthesized to date. A quantitative structure-affinity relationship (QSAR) was derived using triplex binding data for all 14 compounds used in these studies. The QSAR revealed that the primary favorable determinant of triplex binding free energy is the solvent accessible surface area. Triplex binding affinity is negatively correlated with compound electron affinity and the number of hydrogen bond donors. The QSAR provides guidelines for the design of improved triplex-binding agents.
DNA Nucleotide Sequence Restricted by the RI Endonuclease (1972)

The sequence of DNA base pairs adjacent to the phosphodiester bonds cleaved by the RI restriction endonuclease in unmodified DNA from coliphage lambda has been determined. The 5'-terminal nucleotide labeled with (32)P and oligonucleotides up to the heptamer were analyzed from a pancreatic DNase digest. The following sequence of nucleotides adjacent to the RI break made in lambda DNA was deduced from these data and from the 3'-dinucleotide sequence and nearest-neighbor analysis obtained from repair synthesis with the DNA polymerase of Rous sarcoma virus [Formula: see text] The RI endonuclease cleavage of the phosphodiester bonds (indicated by arrows) generates 5'-phosphoryls and short cohesive termini of four nucleotides, (p)A(p)A(p)T(p)T. The most striking feature of the sequence is its symmetry.
University of Bath Department of Mechanical Engineering DMP Online Template (2012)

The addition of ipronidazole to drinking water at concentrations of 50 and 100 mg/L was effective for treatment of experimentally induced swine dysentery in swine because diarrhea receded in most swine within several days after the drug was added. Medicated swine given these concentrations of drug had fewer days of nonhemorrhagic and hemorrhagic diarrhea, higher feed and water consumption, greater body weight gain,and a more favorable feed efficiency than did the nonmedicated, exposed swine. Medicated swine given dosage of 25 mg/L of drinking water had greater frequency of nonhemorrhagic and hemorrhagic diarrhea than did those given the higher concentrations, and diarrhea in some swine did not subside during medication. All medicated swine survived; in contrast, 90% mortality occurred in the nonmedicated swine. In all groups of medicated exposed swine, occasionally there was recurrence of diarrhea.
Wearable handling support system for paralyzed patient (2008)

This paper introduces a new wearable handling support system for a person who has trouble in motor capability of his or her upper limb. The support system is used as not only a support system to make his upper limb active in daily life but also a rehabilitation system to reduce manual loads of physical therapists. The system measures three rotation angles of patientpsilas head: pitch, roll and yaw to control three degrees of freedom of the support system; angle of elbow joint, angle of wrist joint and hand close/open, respectively. Hemiplegia patient who has paralysis of one half of the patient body can use both arms cooperatively by wearing the handling support system on the paralysis side. In our experiments, the system helps pouring task from POP bottle to a glass, while an upper limb on paralysis side of a user grasps the POP bottle and the other upper limb grasps the glass.
Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics and comparison with the canalicular transporter. (1995)

Using the Xenopus oocyte expression system, we previously identified an approximately 4-kb fraction of mRNA from rat liver that expresses sulfobromophthalein reduced glutathione S-conjugate (BSP-GSH)-insensitive and an approximately 2.5-kb fraction expressing BSP-GSH-sensitive reduced glutathione (GSH) transport. From the former, a 4.05-kb cDNA was cloned and characterized as the putative rat canalicular GSH transporter. Starting with a cDNA library constructed from the approximately 2.5-kb fraction, we have now isolated a single clone that leads to expression of a BSP-GSH- and cystathionine-inhibitable GSH transporter activity with Km approximately 3 mM characteristic of the sinusoidal GSH transporter. The cDNA for the rat sinusoidal GSH transporter-associated polypeptide (RsGshT) is 2733 bases with an open reading frame of 1059 nucleotides encoding a polypeptide of 353 amino acids (39,968 Da) with two putative membrane-spanning domains. No identifiable homologies were found in searching various data bases. An approximately 40-kDa protein is generated in in vitro translation of cRNA for RsGshT. Northern blot analysis revealed a single approximately 2.8-kb transcript in rat and human liver with negligible hybridization signal in other organs. The abundance of mRNA for RsGshT did not increase with phenobarbital treatment. Cis-inhibition by BSP-GSH and trans-inhibition by cystathionine and lack of induction by phenobarbital are characteristic of sinusoidal GSH secretion and thus indicate that RsGshT either encodes the sinusoidal GSH transporter itself or a regulatory subunit of the transporter that determines its liver-specific activity.
A NOVEL ONE POT SYNTHESIS OF γ-BUTYROLACTONES* (2002)

ABSTRACT α-Arylidene-γ-phenyl-Δβ,γ-butenolides were converted to the respective γ-butyrolactones in methyl alcohol with sodium borohydride in presence of triethylamine in a single pot. *IICT communication No. 4391. ACKNOWLEDGMENT One of the author (GSR) acknowledges UGC, New Delhi for financial assistance. Notes *IICT communication No. 4391.
Near‐field impedance accurately distinguishes among pericardial, intracavitary, and anterior mediastinal position (2017)

Impedance values are significantly different among these three anatomical compartments. Therefore, impedance can be potentially used as a means to guide percutaneous epicardial access.
Prototyping of an indoor high speed diffuse infrared transceiver for wireless data communications (2002)

A 1 Mbps nondirective infrared transceiver has been reported by Tsaur et al,. (see IEEE Trans. on Consumer Electronics, vol.40, no.1, p.20-27, 1994). A 2 Mbps system is designed and proposed based on the similar architectures without increasing the complexity and power required. In addition, we describe the primary reasons we adopt 4-ary PPM as the core of our second generation 2 Mbps nondirective infrared transceiver and the implementation techniques toward the realization of an efficient but robust prototype.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Diastereoselective Reactions of Chiral Allyl and Allenyl Silanes with Activated C:X .pi.-Bonds (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiastereoselective Reactions of Chiral Allyl and Allenyl Silanes with Activated C:X .pi.-BondsCraig E. Masse and James S. PanekCite this: Chem. Rev. 1995, 95, 5, 1293–1316Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/cr00037a008https://doi.org/10.1021/cr00037a008research-articleACS PublicationsRequest reuse permissionsArticle Views4050Altmetric-Citations492LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On-line recognition of handwritten Chinese characters and alphabets (2002)

An online handwritten-character recognition system is proposed based on stroke-sequence feature extraction and on a string-matching method called the dynamic neighboring matching method. The patterns to be recognized, including Chinese characters and alphabets, are allowed to be stroke-order- and stroke-number-free and tolerant of combined strokes and wrong strokes. Fewer learning samples are needed, but they must be within the constraint of normal handwriting. Reference patterns have been generated from 4000 categories of characters with stroke numbers ranging from 1 to 31. The recognition results are based upon the 3500 Chinese characters written by 10 people. The recognition rate is 93.5%, and the cumulative classification rate of choosing four most-similar characters is up to 98.5%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Oxidation of Ascorbic Acid by Hydrogen Peroxide. Catalysis by Ethylenediaminetetraacetato-Iron(III) (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Oxidation of Ascorbic Acid by Hydrogen Peroxide. Catalysis by Ethylenediaminetetraacetato-Iron(III)Robert R. GrinsteadCite this: J. Am. Chem. Soc. 1960, 82, 13, 3464–3471Publication Date (Print):July 1, 1960Publication History Published online1 May 2002Published inissue 1 July 1960https://doi.org/10.1021/ja01498a057RIGHTS & PERMISSIONSArticle Views1037Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (796 KB) Get e-Alerts Get e-Alerts
A fast empirical approach to binding free energy calculations based on protein interface information (2002)

Three useful variables from the interfaces of 20 protein-protein complexes were investigated. These variables are the side-chain accessible number (N(b)), the number of hydrophilic pairs (N(pair)) and buried a polar solvent accessible surface areas (DeltaDeltaASA(apol)). An empirical model based on the three variables was developed to describe the free energy of protein associations. As the results show, the side-chain accessible numbers characterize the loss of side-chain conformational entropy of protein interactions and the effective empirical function presented here has great capability for estimating the binding free energy. It was found that the variables of interface information capture most of the significant features of protein-protein association. Also, we applied the model based on the variables as a rescoring function to docking simulations and found that it has the potential to distinguish the 'true' binding mode. It is clear that the simple and empirical scale developed here is an attractive target function for calculating binding free energy for various biological processes to rational protein design.
Binding of tRNA to <i>Escherichia coli</i> Ribosomes as Measured by Velocity Sedimentation (1981)

We followed the binding of initiator and elongator tRNA to 70-S ribosomes and its subunits by velocity sedimentation in the analytical ultracentrifuge. This technique shows the advantage over the previously used methods (adsorption of the complexes to nitrocellulose filters or fluorescence titrations) in that no kinetic effects obscure the equilibrium data and that none of the components has to be chemically modified. The concentrations of the macromolecular compounds are kept constant and the binding equilibria are shifted by varying the Mg2+ concentration in a range which is accessible to experimental analysis. Free 30-S ribosomes bind no tRNA, whereas one tRNA molecule is bound to 50-S ribosomal subunits. In the presence of the cognate codon one tRNA can be associated with the small subunit. Free, programmed, or misprogrammed 70-S ribosomes bind exactly two elongator tRNAs. Only the initiator tRNA does discriminate significantly between the two ribosomal sites when bound to a ribosome . A-U-G complex.
Binding activities of <i>cis</i>‐platin‐damage‐recognition proteins in human tumour cell lines (1993)

Proteins can be detected by South-western analyses of human tumour-cell extracts binding to double-stranded oligonucleotide DNA treated in vitro with the chemotherapeutic drug cis-diamminedichloroplatinum (II) (CDDP), but not to untreated DNA. The relative molecular masses of proteins binding to the CDDP-treated double-stranded oligonucleotide are 25, 48 and 97 kDa. The binding activity of 2 of the CDDP-damage-recognition proteins, of relative molecular mass 48 and 97 kDa, is greater in a CDDP-resistant human ovarian tumour cell line than in the parental sensitive line. South-western analysis of a panel of human bladder cell lines and CDDP-sensitive testicular cell lines show consistent patterns of CDDP-damage-recognition proteins within each cell type, however with differences between the 2 cell types. Binding of the proteins to CDDP-damaged DNA and the altered binding activity detected in tumour cell lines suggests that alteration in damage-recognition proteins could play a role in tumour response to CDDP.