gebhart/patrepeval huggingface dataset:
Hyaluronan <sup>1</sup> (1992)

Hyaluronan (hyaluronic acid) is a high‐molecular‐mass polysaccharide found in the extracellular matrix, especially of soft connective tissues. It is synthesized in the plasma membrane of fibroblasts and other cells by addition of sugars to the reducing end of the polymer, whereas the nonreducing end protrudes into the pericellular space. The polysaccharide is eatabolized locally or carried by lymph to lymph nodes or the general circulation, from where it is cleared by the endothelial cells of the liver sinusoids. The overall turnover rate is surprisingly rapid for a connective tissue matrix component ( t ½ 0.5 to a few days). Hyaluronan has been assigned various physiological functions in the intercellular matrix, e.g., in water and plasma protein homeostasis. Hyaluronan production increases in proliferating cells and the polymer may play a role in mitosis. Extensive hyaluronidase‐sensitive coats have been identified around mesenchymal cells. They are either anchored firmly in the plasma membrane or bound via hyaluronan‐specific binding proteins (receptors). Such receptors have now been identified on many different cells, e.g., the lymphocyte homing receptor CD 44. Interaction between a hyaluronan receptor and extracellular polysaccharide has been connected with locomotion and cell migration. Hyaluronan seems to play an important role during development and differentiation and has other cell regulatory activities. Hyaluronan has also been recognized in clinical medicine. A concentrated solution of hyaluronan (10 mg/ml) has, through its tissue protective and rheological properties, become a device in ophthalmic surgery. Analysis of serum hyaluronan is promising in the diagnosis of liver disease and various inflammatory conditions, e.g., rheumatoid arthritis. Interstitial edema caused by accumulation of hyaluronan may cause dysfunction in various organs.—Laurent, T. C.; Fraser, J. R. E. Hyaluronan. FASEB J. 6: 2397‐2404; 1992.
Performance analysis of SIP-based push-to-talk service for GPRS/cdma2000 network (2005)

Push-to-talk service in GRPS/cdma2000 is a type of communications service that sets up a channel between two or more users without the need to dial a connection or set up a call, just like walkie-talkie or private mobile radio (PMR) system. This service is gaining in popularity in recent years due to its resource and cost efficiency and is thought as one of the perspective "killer application" in the digital public mobile data network (DPMDN). In this paper, we evaluate the structure and performance of the PTT service using SIP as call control protocol for present 2.5G DPMDN such as GPRS and cdma2000 1X , and present a improved call control protocol. By making use of the user's pre-knowledge of PTT talking model, this protocol applies a single way signaling structure and simplifies the setup procedure. The analysis result shows this call control scheme can significantly decrease the call delay time - one of the most key factor that influences the user's feeling
A Routine PET/CT Protocol with Streamlined Calculations for Assessing Cardiac Amyloidosis Using 18F-Florbetapir (2015)

This work builds on the seminal work by Dorbala et al. by describing a short (18)F-Florbetapir imaging protocol that is suitable for routine clinical use and uses a simple method for quantitative analysis of cardiac amyloid disease.
3D Java web-based games development and deployment (2009)

Currently, web-based online gaming applications are predominately utilising Adobe Flash or Java Applets as their core technologies. These games are often casual, two-dimensional games and do not utilise the specialist graphics hardware which has proliferated across modern PCs and Consoles. Multi-user online game play in these titles is often either non-existent or extremely limited. Computer games applications which grace the current generation of consoles and personal computers are designed to utilise the increasingly impressive hardware power at their disposal. However, these are commonly distributed using a physical medium or deployed through custom, proprietary networking mechanisms and rely upon platform-specific networking APIs to facilitate multi-user online game play. In order to unify the concepts of these disparate styles of gaming, in this paper we propose a novel integrated development environment called Homura and NetHomura. Homura is based on the Eclipse platform and extends the jME game engine, with new interfaces, content and libraries, thus, providing a software suite that integrates source editors, compilers, including spatial and positional editors to afford advanced graphical functionalities within the IDE. We also present two interconnected systems which are implemented using Java Web Start and JXTA P2P technologies, providing a platform-independent framework capable of deploying hardware accelerated cross-platform, cross-browser online-enabled Java games, as part of the NetHomura Project.
Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma (2002)

Intratumoral concentration of HGF in gliomas is associated with malignancy and poor prognosis. High HGF is also found in meningiomas and is related with long term recurrence. The current findings suggest that the routine measurement of HGF may be used as a predictive factor for planning therapeutic strategies in both malignant gliomas and meningiomas. The potential use of HGF inhibitors or antagonists for therapy of these tumors should be explored.
Pulmonary arterial hypertension: the most devastating vascular complication of systemic sclerosis (2009)

Pulmonary arterial hypertension (PAH) is a devastating vascular complication of a number of CTDs. In patients with SSc, PAH has a dramatic impact on prognosis and survival and is the single most common cause of disease-related death.Yearly echocardiographic screening for PAH is recommended in patients with SSc. If suspected, confirmation of PAH diagnosis by right heart catheterization is necessary. Treatment goals for patients with PAH associated with SSc (PAH-SSc) aim to slow disease progression and improve quality of life. Some measures used to gauge the effect of treatment in patients with PAH-SSc remain to be fully validated; the 6-min walk distance, for example, is a simple and reproducible means of assessing exercise capacity, but there exists a need to understand what constitutes a clinically relevant change in this specific patient population. Currently, pharmacological intervention in PAH-SSc may target one or more of three pathophysiological pathways in PAH. The prostacyclin analogue epoprostenol has been shown to improve exercise capacity and haemodynamics in PAH-SSc patients and similar data are available from smaller studies on trepostinil and iloprost. The dual endothelin receptor antagonist bosentan has been shown to improve exercise capacity and haemodynamics in PAH-SSc, and similar data have been obtained in small numbers of patients treated with the endothelin receptor A antagonists sitaxsentan and ambrisentan. Impaired production of nitric oxide may be addressed by inhibiting phosphodiesterase type-5 with sildenafil or possibly tadalafil. Combinations of multiple targeted therapies may be beneficial to this patient population.
Current Developments in the Use of Biomarkers for Juvenile Idiopathic Arthritis (2014)

Use of biomarkers in clinical practice has proved extremely valuable and is a rapidly expanding field. However, despite the huge potential of biomarkers, for juvenile idiopathic arthritis (JIA) there are currently no validated paediatric biomarkers available to help with setting up a more tailored approach on which drug choice could be based, to achieve remission early in the course of disease. Early remission reduces burden of disease, limits side effects from toxic and unnecessary medication, and, most importantly, enhances quality of life. Several studies have suggested promising biomarkers: these may be a protein, cellular component, mRNA, or genetic component, for example a single nucleotide polymorphism (SNP). Here we describe recent developments in the use of biomarkers for JIA and their potential to assist in management of disease by predicting disease phenotype, severity, progression, and response to treatment, and determining when patients have reached stable remission and can safely discontinue treatment.
<b>The Structure of Mitomycin A″</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of Mitomycin A″A. TulinskyCite this: J. Am. Chem. Soc. 1962, 84, 16, 3188–3190Publication Date (Print):August 1, 1962Publication History Published online1 May 2002Published inissue 1 August 1962https://pubs.acs.org/doi/10.1021/ja00875a034https://doi.org/10.1021/ja00875a034research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cardiac hypertrophy: A matter of translation (2003)

1. Left ventricular hypertrophy (LVH) of the heart is an adaptive response to sustained increases in blood pressure and hormone imbalances. Left ventricular hypertrophy is associated with programmed responses at the molecular and biochemical level in different subsets of cardiac cells, including the cardiac muscle cells (cardiomyocytes), fibroblasts, conductive tissue and coronary vasculature. 2. Regardless of the initiating cause, the actual increase in chamber enlargement is, in each case, due to an increase in size of a pre-existing cardiomyocyte population, with little or no change in their number; a process referred to as cellular hypertrophy. 3. An accelerated rate of global protein synthesis is the primary mechanism by which protein accumulation increases during cardiomyocyte hypertrophy. In turn, increased rates of synthesis are a result of increased translational rates of existing ribosomes (translational efficiency) and/or synthesis and recruitment of additional ribosomes (translational capacity). 4. The present review examines the relative importance of translational capacity and translational efficiency in the response of myocytes to acute and chronic demands for increased protein synthesis and the role of these mechanisms in the development of LVH.
Advances in Organophosphorus Chemistry Based on Dichloro(methyl)phosphane (1981)

Abstract Besides phosphorus trichloride and phosphane, dichloro(methyl)phosphane is gaining importance as a starting material for the synthesis of organophosphorus compounds. It provides ready access to phosphonic, phosphinic and phosphonous acid derivatives, as well as their secondary products. The synthetic and application potential of organophosphorus compounds—based on industrially produced dichloro(methyl)phosphane—is illustrated by means of numerous examples.
Results of the CONTROL Trial: Efficacy and Safety of Recombinant Activated Factor VII in the Management of Refractory Traumatic Hemorrhage (2010)

rFVIIa reduced blood product use but did not affect mortality compared with placebo. Modern evidence-based trauma lowers mortality, paradoxically making outcomes studies increasingly difficult.
Synthesis and Analgesic Activities of Some 2-Amino-1, 1-dialkyl-7-methoxy-1, 2, 3, 4-tetrahydronaphthalenes and the Related Compounds (1976)

The synthesis of a series of 2-amino-1, 1-dialkyl-7-methoxy-1, 2, 3, 4-tetrahydronaphthalenes and the related compounds is described and their analgesic activities are reported. As measured by the acetic acid writhing method for the preliminary screening test, the introduction of geminal diethyl groups in the methylene at position 1 of 2-amino-1, 2, 3, 4-tetrahydronaphthalene enhances the analgesic activities. The substitution in 2-amino group decreases the activities. ED50 values of four compounds were checked by the acetic acid writhing, electric stimulation, and hot plate methods.
High-mobility low-threshold-voltage pentacene thin-film transistors prepared at rapid growth rates by pulsed-laser deposition (1997)

ABSTRACT Organic thin films are of increasing interest as active media in thin-film electronic devices. Pulsed-laser deposition (PLD) constitutes a novel and highly promising but at present ill-characterized recent addition to available fabrication techniques. In this paper, we report very promising measurements on PLD films of pentacene, comparing them with the characteristics of their more conventional counterparts obtained by thermal evaporation (TE). It is shown that PLD is capable of achieving significant improvements in device characteristics, whilst simultaneously allowing films to be deposited at least 100 times faster than TE. Surface morphology analysis by atomic force microscopy and scanning electron microscopy suggests that the enhanced properties are associated with appreciably improved molecular ordering. PLD thin-film transistors (TFTs) deposited onto room-temperature substrates - 2 2- 1- 1 exhibit a field-effect mobility of 3 10 cm V s, a 0.25 V threshold FE voltage, and an on-to-off current ratio of more than 1400. In contrast, TE devices prepared under otherwise identical conditions exhibit a of only FE - 4 2- 1- 1 about 10 cm V s, a 0.8 V threshold voltage and an on-to-off ratio of 240. The mobility values for the PLD TFTs are already the highest reported for undoped pentacene devices and are sufficient to make the material viable for prototype active circuits. Moreover, our most recent experiments have established that raising the substrate temperature during PLD deposition to 473 K yields a dramatic reduction in the surface roughness of films, to a value of 0.4 nm, which is comparable with the dimensions of the pentacene molecule! This is accompanied by further improvements in electrical conductivity, offering exciting possibilities for devices of even higher performance.
A new EUVE-detected flare star (EUVE J0613-23.9B) (2003)

Extreme Ultraviolet Explorer (EUVE) observations have provided detailed spectroscopic and timing studies of several flare stars, including AU Mic (Cully et al., 1993), AD Leo (Hawley et al., 1995) and EQ Peg (Monsignori-Fossi et al., 1995).\n In this bulletin, we present the EUVE and optical follow-up observations of a newly detected flare star. This star was serendipitously discovered during an EUVE observation of the G star HD 43162 as part of the analysis for the 3rd EUVE Right Angle Program Catalog (Christian, 2002). Analysis of the EUVE spectra obtained during the largest flare (Fe XIX-XXIV emission and a strong 300-650 Å continuum) have been presented elsewhere (Christian et al., 2003). We present optical spectroscopy and results obtained at MT Stromlo Observatory to identify the optical counterpart in § 1, and the long-term EUVE Deep Survey light-curves in § 2.
A Hybrid Simulated Annealing Algorithm for the Three-Dimensional Packing Problem (2009)

This paper presents an efficient hybrid simulated annealing algorithm for three dimensional container loading problem (3D-CLP). The 3D-CLP is the problem of loading a subset of a given set of rectangular boxes into a rectangular container so that the stowed volume is maximized. The algorithm introduced in this paper is based on three important algorithms. First,complex block generating,complex block can contain any number boxes of different types,which differs from the traditional algorithm. Second,basic heuristic,which is a new construction heuristic algorithm used to generate a feasible packing solution from a packing sequence. Third,simulated annealing algorithm,based on the complex block and basic heuristic,it encodes a feasible packing solution as a packing sequence,and searches in the encoding space to find an approximated optimal solution. 1500 benchmark instances with weakly and strongly heterogeneous boxes are considered in this paper. The computational results show that the volume utilization of hybrid algorithm outperforms current excellent algorithms for the considered problem.
Quantitative Assessment of the T2 Relaxation Time of the Gluteus Muscles in Children with Duchenne Muscular Dystrophy: a Comparative Study Before and After Steroid Treatment (2010)

T2 mapping is a feasible technique to evaluate the longitudinal muscle changes in those children who receive steroid therapy for DMD. The differences of the mean T2 relaxation time may reflect alterations in disease activity, and even when the conventional MRI and CFS remain stable.
Advanced Normalization Tools: V1.0 (2009)

We provide examples and highlights of Advanced Normalization Tools (ANTS) that address practical problems in real data. A variety of image and point similarity metrics and elastic, diffeomorphic, affine and other variations of transformation models are available.
<i>rexB</i> of bacteriophage λ is an anti-cell death gene (1998)

In Escherichia coli, programmed cell death is mediated through "addiction modules" consisting of two genes; the product of one gene is long-lived and toxic, whereas the product of the other is short-lived and antagonizes the toxic effect. Here we show that the product of lambdarexB, one of the few genes expressed in the lysogenic state of bacteriophage lambda, prevents cell death directed by each of two addiction modules, phd-doc of plasmid prophage P1 and the rel mazEF of E. coli, which is induced by the signal molecule guanosine 3',5'-bispyrophosphate (ppGpp) and thus by amino acid starvation. lambdaRexB inhibits the degradation of the antitoxic labile components Phd and MazE of these systems, which are substrates of ClpP proteases. We present a model for this anti-cell death effect of lambdaRexB through its action on the ClpP proteolytic subunit. We also propose that the lambdarex operon has an additional function to the well known phenomenon of exclusion of other phages; it can prevent the death of lysogenized cells under conditions of nutrient starvation. Thus, the rex operon may be considered as the "survival operon" of phage lambda.
Financial prediction and trading strategies using neurofuzzy approaches (1998)

Neurofuzzy approaches for predicting financial time series are investigated and shown to perform well in the context of various trading strategies involving stocks and options. The horizon of prediction is typically a few days and trading strategies are examined using historical data. Two methodologies are presented wherein neural predictors are used to anticipate the general behavior of financial indexes (moving up, down, or staying constant) in the context of stocks and options trading. The methodologies are tested with actual financial data and show considerable promise as a decision making and planning tool.
HYPOTENSIVE RESUSCITATION (1996)

While the mechanism remains unclear, a growing body of experimental and clinical evidence suggests that aggressive crystalloid resuscitation in near fatal uncontrolled hemorrhage is associated with poor outcome. Limited attempts to restore blood pressure improve cardiac output, tissue perfusion, and survival while attempts to restore normal tension with crystalloid result in increased hemorrhage volume and higher mortality. The current standard of therapy for treatment of hemorrhagic shock includes initial aggressive crystalloid resuscitation. This mini-review summarizes some of the experimental and clinical data suggesting that this approach may not be desirable in the presence of uncontrolled hemorrhage following injury.
Lignocellulose degradation by microorganisms from termite hills and termite guts: A survey on the present state of art (1994)

In several aspects termites are a fascinating group of insects having attracted the interest of many researchers. They exhibit a complex social behavior and caste differentiation occurring elsewhere only among the hymenoptera. In an enlarged part of the hindgut, the paunch, termites have established a unique symbiotic association with prokaryotic and eukaryotic microorganisms. A similar flora is also found in wood-eating roaches of the genus Cryptocercus. The study of symbiosis between termites and their intestinal microbes is of general interest, because due to this symbiotic interaction termites can feed on complex biopolymers such as wood. Flagellates and bacteria occur in the gut of lower termites, while higher termites possess only bacteria. In particular spirochetes are abundant in the termite gut. Apart from spirochetes and other more common bacteria, actinomycetes, yeasts and fungi have also been isolated from different species of termites. This review summarizes the distinct role of the intestinal flora in degradation of wood components such as cellulose, hemicellulose and lignin.
Developmental and corrective biomechanics for scoliosis (1991)

The developmental mechanism for scoliosis and its surgical correction are studied by modeling the spinal column as a curved nonlinear (large-deformation-sustaining) beam column to which are applied (a) muscle forces to simulate scoliosis development due to asymmetrical bilateral muscle contractions and (b) corrective forces to simulate the action of surgically implanted corrective systems. The two-dimensional model permits curvature in the frontal plane and can simulate and demonstrate the progression of a scoliotic curve from an initially straight configuration for various model parameter values. The calculation of the bonding moments is treated, and a simple algorithm for solving the model equations is presented. Results for an actual clinical case are given.
Wearable Affective Life-Log System for Understanding Emotion Dynamics in Daily Life (2019)

Past research on recognizing human affect has made use of a variety of physiological sensors in many ways. Nonetheless, how affective dynamics are influenced in the context of human daily life has not yet been explored. In this work, we present a wearable affective life-log system (ALIS), that is robust as well as easy to use in daily life to detect emotional changes and determine their cause-and-effect relationship on users' lives. The proposed system records how a user feels in certain situations during long-term activities with physiological sensors. Based on the long-term monitoring, the system analyzes how the contexts of the user's life affect his/her emotion changes. Furthermore, real-world experimental results demonstrate that the proposed wearable life-log system enables us to build causal structures to find effective stress relievers suited to every stressful situation in school life.