gebhart/patrepeval huggingface dataset:
Tumor‐associated antigen 90K/Mac‐2‐binding protein: Possible role in colon cancer (2006)

The tumor-associated antigen 90K (TAA90K)/Mac-2-binding protein implicated in cancer progression and metastasis is modified by beta1-6 branched N-linked oligosaccharides in colon cancer cells, glycans shown to contribute to cancer metastasis. To elucidate the role of TAA90K in colon cancer, we examined its expression and function in human colon tumors and colon carcinoma cell lines. Immunohistochemical analyses of colon tumors revealed elevated expression of TAA90K in all samples analyzed compared to normal colon. To examine the function of TAA90K in colon cancer, we carried out protein and cell binding assays using TAA90K-His purified from HT-29 cells colon carcinoma cells infected with recombinant vaccinia virus expressing TAA90K containing a C-terminal poly-histidine tag. TAA90K-His bound to fibronectin, collagen IV, laminins-1, -5, and -10 and galectin-3 (Mac-2) but poorly to collagen I and galectin-1. As expected, binding of TAA90K to galectin-3 was dependent on carbohydrate since it was inhibitable by lactose and asiolofetuin, and a TAA90K-His glycoform purified from HT-29 cells treated with the glycosylation inhibitor 1-deoxymannojirimycin bound poorly to galectin-3. Unlike TAA90K isolated from other cell types, TAA90K-His isolated from colon cancer cells failed to mediate adhesion of colon cancer and normal cell lines, possibly due to cell-type specific glycosylation of TAA90K-His and/or its putative cellular receptor. However, at low concentrations, TAA90K-His enhanced galectin-3-mediated HT-29 cell adhesion while at high concentrations, it inhibited cell adhesion. Thus, a possible mechanism by which TAA90K may contribute to colon cancer progression is by modulating tumor cell adhesion to extracellular proteins, including galectin-3.
Localizational Alterations of Calcium, Phosphorus, and Calcification-Related Organics Such as Proteoglycans and Alkaline Phosphatase During Bone Calcification (2001)

To further approach the mechanisms of bone calcification, embryonic rat calvariae were observed at electron microscopic level by the means of fine structures and various cytochemical localizations, including nonspecific proteoglycan (PG) stained by cuprolinic blue (CB), decorin, chondroitin sulfate, hyaluronan, and alkaline phosphatase (ALP), as well as the elemental mapping of calcium (Ca) and phosphorus (P) by energy-filtering transmission electron microscopy (EFTEM). In the calvariae, calcification advanced as the distance from osteoblasts increased. Closer to the osteoblasts, the osteoid was marked by an abundance of CB-positive PGs around collagen fibrils. After crystallization within matrix vesicles, calcified nodules formed and expanded, creating a coherent calcified matrix. The sizes of CB-positive PG-like structures diminished as calcification proceeded. Although small CB-positive structures were accumulated in early stage-calcified nodules, they were localized along the periphery of larger calcified nodules. Cytochemical tests for decorin, chondroitin sulfate, and hyaluronan determined their presence in the areas around collagen fibrils of the osteoid, as well as in and around calcified nodules, whereas ALP was found in the matrix vesicles, as well as in and around the calcified nodules. Ca tended to localize at the PG sites, while P often mapped to the collagen fibril structures, in the uncalcified matrix. In contrast, Ca/P colocalization was visible in and around the calcified nodules, where ALP and smaller CB-positive structures were observed. The difference in the localization patterns of Ca and P in uncalcified areas may limit the local [Ca2+][PO4(3-)] product, leading to the general inhibition of hydroxyapatite crystallization. The downsizing of CB-positive structures suggested enzymatic fragmentation of PGs. Such structural alterations would contribute to the preservation and transport of calcium. ALP possesses the ability to boost local phosphate anion concentration. Therefore, structurally altered PGs and ALP may cooperate in Ca/P colocalization, thus promoting bone calcification.
Improving GHB withdrawal with baclofen: study protocol for a feasibility study for a randomised controlled trial (2016)

v3.1, 1 February 2016.
Retrograde Amnesia Produced by Hippocampal Spreading Depression (1968)

Injection of potassium chloride into the hippocampus produces a disruption of electrical activity; a concomitant of this disruption is a deficit in retention of conditioned suppression learned 24 hours before injection.
Multiple Myeloma: What's New (2001)

With conventional therapy, only 5% of multiple myeloma patients achieve complete response. But in recent clinical trials of high-dose therapy with autologous hematopoietic stem cell transplant, complete remission rates of 25-30% can be affected with median survival exceeding 5 years. Newer approaches in clinical trials, including more potent induction regimens utilizing thalidomide, alone or in combination with dexamethasone, are improving treatment outcomes. The authors suggest that potential for a cure now appears to be within reach.
Photon Blockade Effect in Optomechanical Systems (2011)

We analyze the photon statistics of a weakly driven optomechanical system and discuss the effect of photon blockade under single-photon strong coupling conditions. We present an intuitive interpretation of this effect in terms of displaced oscillator states and derive analytic expressions for the cavity excitation spectrum and the two-photon correlation function g(2)(0). Our results predict the appearance of nonclassical photon correlations in the combined strong coupling and sideband resolved regime and provide a first detailed understanding of photon-photon interactions in strong coupling optomechanics.
Nonlinear viscoelasticity of “hard elastic” polypropylene fibers (1976)

Abstract “Hard elastic” polypropylene fibers respond nonlinearly to stress at all strains. Low tenacities at break (less than 1 g/denier), low moduli of elasticity (slopes of stress‐strain curves from 2.8 to 28 g/denier), and large breaking extensions (over 800 percent) are characteristic of “hard elastic” fibers. Behavior in simple extension, cyclic extension, and stress relaxation can be represented by a quasi‐linear viscoelastic model which uses a continuous relaxation spectrum and a quasilinear relation between stress history T ( t )and strain history λ( t ): where T e [λ( t )] is the elastic response. When creep data are available, this model should provide a unified representation of experimental observations.
Synthesis of Twisted Intercalating Nucleic Acids Possessing Acridine Derivatives. Thermal Stability Studies (2006)

Twisted intercalating nucleic acids (TINA) possessing acridine derivatives have been synthesized via the postsynthetic modifications of oligonucleotides possessing insertions of (R)-1-O-(4-iodobenzyl)glycerol (8) or (R)-1-O-(4-ethynylbenzyl)glycerol (9) at the 5'-end or in the middle as a bulge. In the first postsynthetic step, oligonucleotides 8 and 9 on the CPG support were treated with a Sonogashira coupling reaction mixture containing 9-chloro-2-ethynylacridine or 9-chloro-2-iodoacridine, respectively. After the postsynthetic step, treatment of the oligonucleotides with 32% aq ammonia or 50% ethanolic solution of tris(2-aminoethyl)amine led to the substitution of chloride on acridine concurrent with deprotection of the bases and cleavage of the oligonucleotides from CPG. Molecular modeling of the parallel triplex with a bulged insertion of the monomer (R)-3-O-[4-(9-aminoacridin-2-ylethynyl)benzyl]glycerol in the triplex-forming oligonucleotide (TFO) showed that the acridine moiety was stacking between the bases of the duplex, while phenyl was placed between the bases of the TFO. Thermal denaturation studies and fluorescence properties of TINA-acridine oligonucleotide duplexes and triplexes are discussed.
Magnetic fields of the human body (1975)

In France, around 1780, many Parisians believed in curing their illnesses by magnetism. To perform this cure, they sat in a group around a tub containing “mesmerized” water and iron filings; this was part of the cult introduced to Paris by Dr Franz Mesmer. He proclaimed that animal magnetism of the human body controlled the flow of a universal fluid through the body and that illness resulted when there was an obstacle to that flow. The illness would be cured by magnetically redirecting the fluid with arrangements such as the filings and water.
Utilization of Potato Processing Waste for Compound Cattle Feed (2013)

Feed constitutes about 60–70% of total cost of livestock production. By-products of fruit and vegetable processing industries such as (potato pulp, rejected potato chips, apple pomace, skin/seed of tomatoes etc.) can be used as feed ingredient through proper processing. Compound cattle feed was prepared by partially replacing grain component by the by products of potato processing industry. Feed was prepared by using rejected potato chips (P1) and potato pulp (P2) and compared with the locally available feed (M). P1 with rejected potato chips had the lowest moisture content (10.07%) and maximum ether extract content (17.57%) than Mand P2. Hemicelluloses content was more and cellulose content was observed to be less in P1 and P2 as compared to M. Bulk density and true density, 635.8 kg/m3 and 963.5 kg/m3 were highest for P1 and lowest for P2 (629.9 kg/m3 and 960.06 kg/m3) respectively. P1 and P2 had good pellet durability index, because potato as a feed ingredient also acted as a binder. Physico-chemical characteristics of the feed samples containing by-products of potato processing industry met the required quality standards of compound cattle feed. Potato processing waste could partially replace the grain component in feed pellets.
Exploring mechanisms of resistance to dimethachlone in <i>Sclerotinia sclerotiorum</i> (2015)

This study demonstrates that resistance to dicarboximide fungicide dimethachlone in S. sclerotiorum is emerging in China. Several fitness parameters, including mycelial growth rate, sclerotia formed in vitro, aggressiveness on leaves and osmotic and H2 O2 sensitivity, indicate that the resistant strains may not effectively compete with sensitive isolates in the field in the absence of selection pressure. Lost expression or the V238A point mutation in the SsOs1 gene may confer resistance to dicarboximide fungicide dimethachlone in S. sclerotiorum, but this study illustrates that other, yet unknown mechanisms also exist.
α-Galactosidase A Expressed in the Salivary Glands Partially Corrects Organ Biochemical Deficits in the Fabry Mouse Through Endocrine Trafficking (2010)

Fabry disease is caused by an X-linked deficiency of the lysosomal enzyme α-galactosidase A (GLA) and has been treated successfully with enzyme replacement therapy (ERT). Gene therapy has been proposed as an alternative to ERT due to the presumed advantages of continuous, endogenous production of the therapeutic enzyme. GLA production in the liver and its therapeutic efficacy in the Fabry mouse have been demonstrated previously with various viral vector systems. In consideration of the potential advantages of using the salivary glands as endogenous GLA biosynthesis sites, we explored the feasibility of this approach in the Fabry mouse. GLA -/0 or -/- mice received an adenoviral vector (2 × 10(10) or 1 × 10(9) viral particles) expressing GLA to the right submandibular gland via oral cannulation of the submandibular duct. Four days later, animals were sacrificed; saliva, plasma, kidney, liver, and brain were collected and assayed using ELISA, Western blot, and a GLA enzymatic activity assay using both traditional fluorescence methods and isotope dilution mass spectrometry by following the U.S. EPA Method 6800. GLA activity was significantly elevated in the serum and liver of both treatment groups, and improvement in the kidney was marginally significant (P < 0.069) in the high-dose group. Notably, we found that liver and salivary gland produce different glycoforms of the GLA transgene. Only small numbers of adenoviral genomes were observed in the livers of treated animals, but in four of 14 in the high-dose groups, liver levels of adenovirus exceeded 20 copies/μg, indicating that the sequestration in the salivary gland was imperfect at high doses. Taken together, these results indicate that the salivary gland-based gene therapy for Fabry disease is promising, and further studies with advanced viral vector gene delivery systems (e.g., adeno-associated virus) for long-term treatment appear to be warranted.
Documenting software systems with views II (2001)

Software engineers rely on program documentation as an aid in understanding the functional nature, high-level design, and implementation details of complex applications. Without such documentation, engineers are forced to rely solely on source code. This is a time-consuming and error-prone process, especially when one considers the amount of information assimilation and domain mapping that is required to understand the architecture of a large-scale software system. This paper describes an integrated approach to documenting software systems based on XML. In particular, the paper focuses on the creation and use of specific Document Type Definitions (DTD) that are defined by MSR as a standard for software documentation. MSR is a consortium of several German automotive companies whose goal is to support cooperative development between car manufacturers and their electronic system suppliers. To illustrate the approach, selected aspects of the document creation process for an engine control system are presented.
Clinical Impact Associated with Corrected Results in Clinical Microbiology Testing (2005)

We developed a strategy to determine the clinical impact associated with errors in clinical microbiology testing. Over a 9-month period, we used a sequential three-stage method to prospectively evaluate 480 consecutive corrected microbiology laboratory reports. The three stages were physician review of the corrected report, medical record review, and interview with the clinician(s) taking care of the patient. Of the 480 corrected reports, 301 (62.7%) were ruled out for significant clinical impact by physician review and an additional 25 cases (5.2%) were ruled out for clinical impact by medical record review. This left 154 cases (32.1%) that required clinician interview to determine clinical impact. The clinician interview revealed that 32 (6.7%) of the corrected reports were associated with adverse clinical impact. Of these 32 cases, 19 (59.4%) involved delayed therapy, 8 (25.0%) involved unnecessary therapy, 8 (25.0%) were associated with inappropriate therapy, and 4 (12.5%) were associated with an increased level of care. The laboratory was entirely responsible for the error in 28 (87.5%) of the 32 cases and partially responsible in the other 4 cases (12.5%). Twenty-six (81.3%) of the 32 cases involved potentially preventable analytic errors that were due to lack of knowledge (cognitive error). In summary, we used evaluation of corrected reports to identify laboratory errors with adverse clinical impact, and most of the errors were amenable to laboratory-based interventions. Our method has the potential to be implemented in other laboratory settings to identify and characterize errors that impact patient safety.
A prospective, randomized, controlled trial of covered expandable metal stents in the palliation of malignant esophageal obstruction at the gastroesophageal junction (2001)

Membrane-covered stents have significantly better palliation than conventional bare metal stents because of decreased rates of tumor ingrowth that necessitate endoscopic reintervention for dysphagia.
Application of Ultrafast Papanicolaou Stain to Body Fluid Cytology (2001)

It seems that Ultrafast Papanicolaou stain improves the resolution of cytoplasmic and nuclear details of nonhematopoietic cells in body fluids. However, to detect cancer in all types of fluids, Diff-Quik and CytoRich preparations are also required. We now examine three slides per fluid sample, one slide by each of the three techniques.
Spectral Imaging Using Basis Lights (2013)

Antony Lam1 http://research.nii.ac.jp/~antony Art Subpa-Asa2 art@set.or.th Imari Sato1 http://research.nii.ac.jp/~imarik Takahiro Okabe3 http://www.pluto.ai.kyutech.ac.jp/~okabe Yoichi Sato4 http://www.hci.iis.u-tokyo.ac.jp/~ysato 1 National Institute of Informatics Tokyo, Japan 2 The Stock Exchange of Thailand Bangkok, Thailand 3 Kyushu Institute of Technology Fukuoka, Japan 4 The University of Tokyo Tokyo, Japan
Evaluación económica y análisis del proceso de telemonitorización domiciliaria de pacientes con insuficiencia cardiaca crónica en el Hospital Universitario de Basurto (2021)

La insuficiencia cardiaca (IC) es una patologia de gran repercusion clinica, economica y social. En este contexto surge la necesidad de adaptar y buscar nuevas formas de atencion sanitaria que sean efectivas, eficientes y sostenibles. La aplicacion de las nuevas tecnologias de la informacion y comunicacion para la telemonitorizacion (TLM) de pacientes desde su domicilio constituye una alternativa para la provision de servicios de salud. La participacion de nuestro centro dentro de un proyecto europeo de TLM en IC, nos permitio implementar un sistema de TLM que hemos podido mantener en el tiempo, formando a dia de hoy parte de nuestra cartera de servicios. Existe un gran interes por conocer si la TLM es o no coste-efectiva. El objetivo del presente estudio es analizar el coste que ha supuesto la implementacion del sistema de TLM de IC en nuestro centro y si ha resultado una estrategia coste-efectiva en los pacientes incluidos durante su primer ano de funcionamiento (mayo/2014-junio/2015).Fueron incluidos pacientes con una descompensacion de IC cronica en los ultimos 6 meses: 99 pacientes en el grupo de TLM y 98 en el grupo control. Tras un seguimiento medio de 352,2 dias en el grupo de TLM se produjeron 35 ingresos por IC y 7 muertes y en el grupo control 47 ingresos por IC y 19 muertes. La implantacion del sistema de TLM supuso un gasto de 55.667,29 ? mas (534,6 ? mas de media por paciente) respecto a los cuidados habituales, debido principalmente al coste de los dispositivos de TLM (67.750,47 ?) y al coste por el personal sanitario dedicado a dicha funcion (46.434,82 ?), estimandose un ahorro de 62.243 ? en los ingresos por IC. El gasto en pruebas complementarias y consultas de cardiologia fue muy similar en ambos grupos. La adherencia al programa de TLM fue muy adecuada, con una tasa de transmision media de 0,62 (se transmitio mas de la mitad de los dias). Se generaron un total de 4.423 alarmas, siendo la mas frecuente la de cambio de peso. El ratio de coste-efectividad incremental de nuestro programa de TLM fue de 5.907,18 ? por ano de vida ganado por paciente. Es decir, ganar un ano de vida, mediante la TLM costo 5.907,18 ? mas que con los cuidados habituales. Asumiendo una disponibilidad a pagar de 25.000 ? por ano de vida ganado, podriamos considerar nuestra intervencion como coste-efectiva.
Basic Properties and Design Principles of UWB Antennas (2009)

Basic principles for ultra-wide-band (UWB) radiation are presented and discussed in this paper. The discussion starts with a description of the influence of antennas on UWB transmission. The parameters characterizing antennas in time and in frequency domain are specified. Since the number of possible antenna structures is nearly unlimited, the focus will be on a classification according to different radiation principles. For each of these mechanisms, the typical advantages and disadvantages are discussed, and an example antenna and its characteristics are presented. For a wireless engineer, the problem to solve is the proper design of an antenna with the desired radiation characteristics. The final outcome of this paper is that there exist numbers of UWB antennas, but not each of them is suited for any application, especially in view of radar and communication systems requirements.
Audio-Visual Voice Activity Detection Using Diffusion Maps (2015)

The performance of traditional voice activity detectors significantly deteriorates in the presence of highly nonstationary noise and transient interferences. One solution is to incorporate a video signal which is invariant to the acoustic environment. Although several voice activity detectors based on the video signal were recently presented, merely few detectors which are based on both the audio and the video signals exist in the literature to date. In this paper, we present an audio-visual voice activity detector and show that the incorporation of both audio and video signals is highly beneficial for voice activity detection. The algorithm is based on a supervised learning procedure, and a labeled training data set is considered. The algorithm comprises a feature extraction procedure, where the features are designed to separate speech from nonspeech frames. Diffusion maps is applied separately and similarly to the features of each modality and builds a low dimensional representation. Using the new representation, we propose a measure for voice activity which is based on a supervised learning procedure and the variability between adjacent frames in time. The measures of the two modalities are merged to provide voice activity detection based on both the audio and the video signals. Experimental results demonstrate the improved performance of the proposed algorithm compared to state-of-the-art detectors.
β-Expectation and β-Content Tolerance Limits for Balanced One-Way ANOVA Random Model (1984)

This article discusses procedures for computing tolerance limits for a population consisting of many batches. The results of Mee and Owen (1983) for one-sided β-content tolerance limits are extended to the two-sided case. In addition, β-expectation tolerance limit procedures are presented. The procedures given for the case in which the ratio of the between and within variances is known are exact, whereas the procedures derived for settings in which the ratio is unknown involve an approximation.
Mapping Emotion Terms into Affective Space (2016)

Abstract. Recent empirical work on the semantics of emotion terms across many different cultures and languages, using a theoretical componential approach, suggested that four dimensions are needed to parsimoniously describe the semantic space of the emotion domain as reflected in emotion terms ( Fontaine, Scherer, Roesch, & Ellsworth, 2007 ; Fontaine, Scherer, & Soriano, 2013 ). In addition to valence, power, and arousal, a novelty dimension was discovered that mostly differentiated surprise from other emotions. Here, we further explore the existence and nature of the fourth dimension in semantic emotion space using a much larger and much more representative set of emotion terms. A group of 156 participants each rated 10 out of a set of 80 French emotion terms with respect to semantic meaning. The meaning of an emotion term was evaluated with respect to 68 emotion features representing the appraisal, action tendency, bodily reaction, expression, and feeling components of the emotion process. A principal component analysis confirmed the four-dimensional valence, power, arousal, and novelty structure. Moreover, this larger and much more representative set of emotion terms revealed that the novelty dimension not only differentiates surprise terms from other emotion terms, but also identifies substantial variation within the fear and joy emotion families.