gebhart/patrepeval huggingface dataset:
Mesothelin-targeted CAR-T cell therapy for solid tumors (2020)

<b>Introduction</b>: Mesothelin (MSLN) is a tumor differentiation antigen normally restricted to the body's mesothelial surfaces, but significantly overexpressed in a broad range of solid tumors. For this reason, MSLN has emerged as an important target for the development of novel immunotherapies. This review focuses on anti-MSLN chimeric antigen receptor (CAR) T cell immunotherapy approaches.<b>Areas covered</b>: A brief overview of MSLN as a therapeutic target and existing anti-MSLN antibody-based drugs and vaccines is provided. A detailed account of anti-MSLN CAR-T cell approaches utilized in preclinical models is presented. Finally, a comprehensive summary of currently ongoing and completed anti-MSLN CAR-T cell clinical trials is discussed.<b>Expert opinion</b>: Initial trials using anti-MSLN CAR-T cells have been safe, but efficacy has been limited. Employing regional routes of delivery, introducing novel modifications leading to enhanced tumor infiltration and persistence, and improved safety profiles and combining anti-MSLN CAR-T cells with standard therapies, could render them more efficacious in the treatment of solid malignancies.
Correlation between the catalytic activity of raney nickel and its structure (1964)

E. M. Hofer and H. E. Hintermann, Trans. Faraday Soc., 1964, 60, 1457 DOI: 10.1039/TF9646001457
Research on Miniaturization of Low - Frequency Range SMD Crystal Unit (2007)

In this paper, the realization of miniature design for low-frequency for SMD crystal units has been presented. Increasing progress towards miniaturization of electronics part which includes ultra-small crystal units have evolved significantly in the last few years. However, miniaturization for crystal units categorically excluded designs for specific low-frequencies due to its extreme difficulties. This research explains the difficulties and introduce the a SMD crystal unit that is until recently unable to realize this complicated low-frequency (8 MHz ~ 4 MHz range) in a package measuring 8.0 times 4.5 times 1.8 mm which employs the thickness-shear vibration mode that features superior temperature characteristic.
UTAUT를 적용한 전자정부 서비스 채택 요인에 관한 연구: 인터넷과 Kiosk의 비교를 중심으로 (2010)

The objective of this study was to investigate the determinants. as well as the type of IT. such as internet and kiosk. differences. in the acceptance of e-Government service based on the unified theory of acceptance and use of technology(UTAUT) proposed by Venkatesh, Morris. Davis and Davis(2003). Data collected from 272 respondents in Korea were tested against the research model using the structural equation modelling approach. The results indicate that performance expectancy. effort expectancy, social influence, and facilitate condition were all significant determinants of behaviora.1 intention to use e-Government service. We also found that type of IT service, such as internet and kiosk, moderate on the relationship between performance expectancy. effort expectancy, social influence. facilitate condition and IT service use intention. These findings provide several important implications for e-Government service acceptance, in terms of both research and practice.
Coronavirus Infection in Acute Lower Respiratory Tract Disease of Infants (1974)

A serologic surveillance of lower respiratory tract disease in 417 hospitalized children under 18 months of age revealed infection with coronaviruses (strains OC43 and/or 229E) in 34 (8.2%). During the same interval, one of 13 control infants was infected. There were two distinct periods lasting six and 14 weeks, respectively, during which the incidence rose to as high as 18.9% of patients with lower respiratory tract disease. The incidence of coronavirus infection in patients with pneumonia and bronchiolitis was higher than the incidences of adenoviruses, influenza, parainfluenza viruses types 1 and 2, and rhinoviruses, and lower only than the incidences of parainfluenza virus type 3 and respiratory syncytial virus. Coronaviruses serologically similar or identical to strain 229E were recovered from frozen nasal washes obtained during the acute phase of pneumonia in two children.
Concise encyclopedia of plastics (2001)

A Plastics Overview: Figures and Tables.- The Plastics Phenomenon.- SPI: The Industry's Voice.- Challenge 2000: Making Plastics a Preferred Material.- Advancing the Plastics Industry Through Education and Research.- Modern Plastics in the Year 2000.- Plastics Technology in the New Millennium.- Plastics News: Born to Feed Need for News.- Molding Our Future Vision.- Thinking Like a Manager and Managing for the Long Run.- Making Marketing Work.- The Plastics Industry: All Sectors, Including Machinery and Equipment.- Basics and Overviews of Plastics Fabricating Processes.- Guide to Processing Basics and Overview into the Future with Pictorial Views.- Fundamentals of Designing with Plastics and Reinforced Plastics.- Alphabetical Listing A to Z.- Appendices.- Appendix A. List of Abbreviations.- Appendix B. Conversion Tables.- Appendix C. Worldwide Plastics Industry Associations.- Appendix D. Worldwide Plastics Industry Events.- Appendix E. U.S. Government Publications and Groups.- Appendix F. Trade Magazines and Publications.- Appendix G. Websites on Plastics.- References.- About the Authors.
IL-1 Induced Chemokine Production Through the Association of Syk with TNF Receptor-Associated Factor-6 in Nasal Fibroblast Lines (2001)

The fibroblasts stimulated by cytokines released the chemokine and recruited the infiltrating cells, including eosinophils, that play a key role in the pathogenesis of airway disease. We established the human fibroblast lines showing high Syk expression and the lines showing low Syk expression from pieces of nasal polyp. IL-1 induces the interaction of TNFR-associated factor (TRAF) 6 with IL-1R-associated kinase, which is rapidly recruited to the IL-1R after IL-1 induction, whereas TRAF2 participates in TNF-alpha-signaling. In the present study, we found that Syk played a different role in IL-1- and TNF-alpha-induced chemokine production through a signaling complex involving Syk and TRAF6. Overexpression of wild-type Syk by gene transfer enhanced RANTES production from nasal fibroblasts stimulated with IL-1. The decrease of Syk expression by the administration of Syk antisense inhibited RANTES production in response to IL-1. However, the change of Syk expression did not affect RANTES production by TNF-alpha stimulation. We concluded that Syk is required for the IL-1-induced chemokine production through the association with TRAF-6 in fibroblasts of nasal polyps.
Spatiotemporal change of sky polarization during the total solar eclipse on 29 March 2006 in Turkey: polarization patterns of the eclipsed sky observed by full-sky imaging polarimetry (2008)

Using 180 degrees field-of-view (full-sky) imaging polarimetry, we measured the spatiotemporal change of the polarization of skylight during the total solar eclipse on 29 March 2006 in Turkey. We present our observations here on the temporal variation of the celestial patterns of the degree p and angle alpha of linear polarization of the eclipsed sky measured in the red (650 nm), green (550 nm), and blue (450 nm) parts of the spectrum. We also report on the temporal and spectral change of the positions of neutral (unpolarized, p = 0) points, and points with local minima or maxima of p of the eclipsed sky. Our results are compared with the observations performed by the same polarimetric technique during the total solar eclipse on 11 August 1999 in Hungary. Practically the same characteristics of celestial polarization were encountered during both eclipses. This shows that the observed polarization phenomena of the eclipsed sky may be general.
Web document classification using modified decision trees (2000)

Searching for Web pages is one of the most common tasks performed on the Web while Web page classification is the first step for Web search service construction. This paper proposes a method for classifying Web documents by using a height-three modified decision tree which splits the root, depth-one nodes, and depth-two nodes based on keywords, descriptions, and hyperlinks, respectively. A classification starts with a Web page at the root of the decision tree and traces paths downward to leaves, which give the categories of the page.
Self-Organizing Neural Networks for Spatial Planning and Flexible Arm Movement Control (1996)

This talk will survey recent results concerning how the brain self-organizes its planning and control of flexible arm movements to accomplish spatially defined tasks at variable speeds and forces with a redundant arm that may be confronted with obstacles. Recent work from our group on this topic includes the following four themes. Theme 1 concerns the design of a neural controller for generating handwriting at variable speeds, sizes, and styles. This model, called VITEWRITE, was first described in Bullock, Grossberg, &amp; Mannes (1993). The VITEWRITE model addresses a number of key issues concerning the skilled performance of sequential actions: What is a motor program? How can a complex movement be flexibly performed at will with variable speed, size, and style
Significance of the Lipid Phase in the Dynamics and Functions of the Xanthophyll Cycle as Revealed by PsbS Overexpression in Tobacco and In-vitro De-epoxidation in Monogalactosyldiacylglycerol Micelles (2004)

The dynamics of the xanthophyll cycle relative to non-photochemical quenching (NPQ) were examined in tobacco plants overexpressing violaxanthin de-epoxidase (VDE), PsbS and PsbS+VDE for effects on NPQ and violaxanthin (V) de-epoxidation over a range of light intensities. Induction of de-epoxidation and NPQ increased in overexpressed VDE and PsbS plants, respectively. Surprisingly, under low light, overexpressing PsbS enhanced de-epoxidation in addition to NPQ. The effect was hypothesized as due to PsbS binding zeaxanthin (Z) or inducing the binding of Z within the quenching complex, thus shifting the equilibrium toward higher de-epoxidation states. Studies in model systems show that Z can stereospecifically inhibit VDE activity against violaxanthin. This effect, observed under conditions of limiting lipid concentration, was interpreted as product feedback inhibition. These results support the hypothesis that the capacity of the thylakoid lipid phase for xanthophylls is limited and modulates xanthophyll-cycle activity, in conjunction with the release of V and binding of Z by pigment-binding proteins. These modulating factors are incorporated into a lipid-matrix model that has elements of a signal transduction system wherein the light-generated protons are the signal, VDE the signal receptor, Z the secondary messenger, the lipid phase the transduction network, and Z-binding proteins the targets.
Mechanical elasticity of single and double clamped silicon nanobeams fabricated by the vapor-liquid-solid method (2005)

Atomic force microscopy has been used to characterize the mechanical elasticity of Si nanowires synthesized by the vapor-liquid-solid method. The nanowires are horizontally grown between the two facing Si(111) sidewalls of microtrenches prefabricated on a Si(110) substrate, resulting in suspended single and double clamped nanowire-in-trench structures. The deflection of the nanowires is induced and measured by the controlled application of normal forces with the microscope tip. The observed reversibility of the nanowire deflections and the agreement between the measured deflection profiles and the theoretical behavior of single and double clamped elastic beams demonstrate the overall beamlike mechanical behavior and the mechanical rigidity of the clamping ends of the nanowire-in-trench structures. These results demonstrate the potential of the nanowire-in-trench fabrication approach for the integration of VLS grown nanostructures into functional nanomechanical devices.
Iron acquisition in Pasteurella haemolytica: expression and identification of a bovine-specific transferrin receptor (1990)

Seven type 1 field isolates of Pasteurella haemolytica were screened for their ability to use different transferrins as a source of iron for growth. All seven strains were capable of using bovine but not human, porcine, avian, or equine transferrin. A screening assay failed to detect siderophore production in any of the strains tested. Iron-deficient cells from these strains expressed a binding activity, specific for bovine transferrin, that was regulated by the level of iron in the medium. Inhibition of expression by translation and transcription inhibitors suggested that iron regulation was occurring at the gene level. Affinity isolation of receptor proteins from all seven strains with biotinylated bovine transferrin identified a 100-kilodalton iron-regulated outer membrane protein as the bovine transferrin receptor. Iron-regulated outer membrane proteins of 71 and 77 kilodaltons were isolated along with the 100-kilodalton protein when less stringent washing procedures were employed in the affinity isolation procedure.
Facilitating reuse of software components using repository technology (2004)

Identifying a reusable component and its functionality is important to heighten productivity of component-based software. A component repository is required to facilitate storing and maintaining reusable software components efficiently. We describe the component repository, which supports to facilitate reuse of software component in component-based software development. Our component repository provides functionality for component reuse process such as specification viewing, adapting, testing, and deploying. Through the component repository with these functions, components can be efficiently reused in component reuse process.
Direct estimation of time-to-impact from optical flow (2002)

The estimation of time to impact is of vital importance for animals as well as for autonomous robots. The optical flow is used to estimate the time to impact. The authors demonstrate that the motion equations that relate the egomotion and/or the motion of the objects in the scene to the optical flow are considerably simplified if the velocity is represented in a polar or log-polar coordinate system, as opposed to a Cartesian representation. In the former case, the time-to-impact can be directly computed from the velocity field and its derivatives. The analysis takes place considering a tracking egomotion, but is then generalized to arbitrary sensor and object motion. The main result stems from the abundance of equations that can be written directly relating the optical flow, represented in a polar or log-polar coordinate system, with the time-to-impact. Experiments performed on images acquired from real scenes are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Analysis of P-Loop and its Flanking Region Subsequence of Diverse NTPases Reveals Evolutionary Selected Residues (2014)

The P-loop NTPases are involved in diverse cellular functions. Members of the P-loop NTPase superfamily are characterized by presence of a highly conserved sequence pattern GxxxxGKS/T, known as Walker A motif. This motif adopts an archetypal P-loop conformation which allows accommodation of the triphosphate moiety of a bound nucleotide. Despite the presence of Walker A as a common sequence motif, P-loop NTPases exhibit extreme sequence divergence which hampers their phylogenetic or evolutionary classification. Here, we show that P-loop and its flanking region subsequence (termed as "extended-WalkerA motif") contain distinct signatures that can be utilized to classify NTPase domain of functionally diverse proteins. We find a clearly classified group of diverse NTPases of Conserved Domain Database such as G-proteins, Ylqf, RecA like, DExDc, AAA, CPT, NK, ABC transporter and NifH proteins.
Successive cancellation decoding of polar codes using stochastic computing (2015)

Polar codes have emerged as the most favorable channel codes for their unique capacity-achieving property. To date, numerous approaches for efficient decoding of polar codes have been reported. However, these prior efforts focused on design of polar decoders via deterministic computation, while the behavior of stochastic polar decoder, which can have potential advantages such as low complexity and strong error-resilience, has not been studied in existing literatures. This paper, for the first time, investigates polar decoding using stochastic logic. Specifically, the commonly-used successive cancellation (SC) algorithm is reformulated into the stochastic form. Several methods that can potentially improve decoding performance are discussed and analyzed. Simulation results show that a stochastic SC decoder can achieve similar error-correcting performance as its deterministic counterpart. This work can pave the way for future hardware design of stochastic polar codes decoders.
Crossing-Aware Channel Routing for Integrated Optics (2014)

Increasing scope and applications of integrated optics necessitates the development of automated techniques for physical design of optical systems. A key area of integrated optic design is waveguide routing, which currently lacks the level of automation found in VLSI design. Unlike VLSI, where signal nets are routed with metal layers and vias, integrated optics is a planar technology and lacks the inherent signal restoration capabilities of static-CMOS. Waveguides suffer signal loss due to planar (perpendicular) waveguide crossings and also from sharp bends. Therefore, in contrast to area or wire length, signal loss minimization - as a function of waveguide crossings and bends - is a primary objective of any routing solution. Our studies show that waveguide routing problems can be suitably formulated as planar channel routing. This paper investigates channel routing for integrated optical waveguides fabricated in a planar substrate. We present routing techniques where crossings, bends, and area are accounted for in an integrated solution. Two distinct channel routing techniques are presented: 1) a new channel router based on net sorting and utilizing non-Manhattan routing grids and 2) a router based on crossing-aware graph-constrained track assignment that also exploits waveguide curves to improve track utilization. Both techniques are crossing-minimal, and are also constrained suitably to reduce bend loss and area. We compare and evaluate the performance of our channel routers on a number of optical design benchmarks.
Digital estimation and correction of DAC errorsin multibit ΔΣ ADCs (2001)

An adaptive digital algorithm is described for acquiring and correcting the errors of the feedback DAC used in a multibit ΔΣ ADC. The method is highly accurate, and is particularly useful for wideband ADCs, where mismatch error shaping becomes ineffective.
Speculative Flow Control for High-Radix Datacenter Interconnect Routers (2007)

High-radix switches are desirable building blocks for large computer interconnection networks, because they are more suitable to convert chip I/O bandwidth into low latency and low cost than low-radix switches. Unfortunately, most existing switch architectures do not scale well to a large number of ports. For example, the complexity of the buffered crossbar architecture scales quadratically with the number of ports. Compounded with support for long round-trip times and many virtual channels, the overall buffer requirements limit the feasibility of such switches to modest port counts. Compromising on the buffer sizing leads to a drastic increase in latency and reduction in throughput, as long as traditional credit flow control is employed at the link level. We propose a novel link-level flow control protocol that enables high-performance scalable routers based on the increasingly popular buffered crossbar architecture to scale to higher port counts without sacrificing performance. By combining credited and speculative transmission, this scheme achieves reliable delivery, low latency, and high throughput, even with crosspoint buffers that are significantly smaller than the round-trip time.
Estimation of Shape Parameter and Measure of Dispersion of Inverse Gaussian Distribution Using Prior Information (2008)

For estimating the shape parameter and measure of dispersion of the Inverse Gaussian distribution, a general class of estimators using prior information has been defined. The resulting estimators have been compared with minimum mean squared error estimator, uniformly minimum variance unbiased estimator, Pandey and Malik (1988) estimator. Realistic conditions have been obtained under which the suggested estimators are better than the well-known minimum mean squared error estimator and uniformly minimum variance unbiased estimator. Numerical illustrations are given in the support of the proposed study.
Soliton transmission at 10 Gbit/s over 2022 km of standard fibre with dispersion compensation (1996)

We present experimental results of 10 Gbit/s, 20 ps soliton data transmission over standard fibre, dispersion compensated to 0.5 ps/nm/km. Acceptable Q values were measured to a distance of 2022 km.
Oxidative Degradation of γ-Butyrolactons into 1,3-Diols via a Criegee Rearrangement of Peroxosulfonates. An Enantioselective Synthesis of Compactin Lactone and its Diastereomer (1993)

The sterically homogenous α,γ-disubstituted γ-butyrolactones trans- and cis-10 were degraded stereoselectively to the 1,3-diols anti-16 and syn-16, respectively. The key step of these transformations were Criegee rearrangements of peroxosulfonates derived from hemiketal peroxides. Syn-16 was transformed into the δ-valerolactone 19 which is a synthon for the compactin lactone. Anti-16 was similarly converted into the diastereomeric valerolactone iso-19.
Optical Stabilizer and Directional Coupler Switch Using Polymer Thin Film Waveguides with Liquid Crystal Clad (1990)

Two types of optical functional devices with a polymer thin film core and liquid crystal clad, to which an electric voltage can be applied, have been fabricated. One type operates as an optical stabilizer and the other operates as an optical directional coupler switch since laser light propagation in these devices can be controlled electrically.
High Temperature Oxidation Resistant Coatings on Molybdenum (1997)

Le molybdene est un metal refractaire utilise a haute temperature dans differents domaines parmi lesquels: les fours industriels, la production du verre et des materiaux ceramiques, les systemes de production de rayons X, l'aerospatial. Au dessus de 600°C le molybdene s'oxyde rapidement a l'air. En consequence, dans des atmospheres non inertes il faut soit refroidir les pieces en molybdene, soit les proteger par des revetements resistant a l'oxydation. Nous avons depose des couches a base de FeCrAl, SiCrFe et MoSi 2 par differentes techniques (projection plasma, depot par trempe, PVD). Ces couches, de differentes epaisseurs, ont subi differents traitements thermiques apres depot. La longevite des revetements a ete determinee. Certains ont resiste plusieurs milliers d'heures a 1200°C et quelques centaines d'heures a 1450°C, lors d'oxydation en conditions isothermes dans l'air. Les defauts locaux etant le facteur cle limitant la longevite, un controle strict des procedes d'elaboration et des echantillons revetus apparait tres important.