gebhart/patrepeval huggingface dataset:
Dual-band technology on indium gallium arsenide focal plane arrays (2011)

While InGaAs-based SWIR imaging technology has been improved dramatically over the past 10 years, the motivation remains to reduce Size Weight and Power (SWaP) for applications in Intelligence Surveillance and Reconnaissance (ISR). Goodrich ISR Systems, Princeton (Sensors Unlimited, Inc.) has continued to improve detector sensitivity. Additionally, SUI is working jointly with DRS-RSTA to develop innovative techniques for manufacturing dual-band focal planes to provide next generation technology for not only reducing SWaP for SWIR imagers, but also to combine imaging solutions for providing a single imager for Visible Near-SWIR (VNS) + LW imaging solutions. Such developments are targeted at reducing system SWaP, cost and complexity for imaging payloads on board UASs as well as soldier deployed systems like weapon sights. Our motivation is to demonstrate capability in providing superior image quality in fused LWIR and SWIR imaging systems, while reducing the total system SWaP and cost by enabling Short Wave and Thermal imaging in a single uncooled imager. Under DARPA MTO awarded programs, a LW bolometer (DRS-RSTA) is fabricated on a Short Wave (SW) InGaAs Vis-SWIR (SUI-Goodrich) Imager. The combined imager is a dual-band Sensor-Chip Assembly which is capable of imaging in VIS-SWIR + LW. Both DRS and Goodrich have developed materials and process enhancements to support these dual-band platform investigations. The two imagers are confocal and coaxial with respect to the incident image plane. Initial work has completed a single Read Out Integrated Circuit (ROIC) capable of running both imagers. The team has hybridized InGaAs Focal planes to 6" full ROIC wafers to support bolometer fabrication onto the SW array.
Tightly Coupled Array Design Based on Phase Center Contour for Indoor Direction Findings in Harsh Environments (2019)

A new model for accurate direction findings is presented, and the superiority of the proposed model is demonstrated over the existing models for real system requirements. The proposed model is constructed based on the phase center contour of each element in the array. It is also shown that the accuracy of the proposed model will remain for tightly coupled arrays while other models fail. A novel algorithm according to this new model is also proposed. The proposed algorithm is proved by both simulations and measurements to be a viable solution for indoor applications where strong multipath interferences exist in the environment. Furthermore, a detailed explanation of accurate direction finding in harsh environments is presented using ultra-miniaturized tightly coupled arrays. In general, the direction-of-arrival estimation accuracy deteriorates using such miniaturized arrays, whereas we have shown that an excellent estimation accuracy is achieved using the proposed model and the detection algorithm. This statement is substantiated for any environments regardless of the strength of interference. To validate the developed model and theory, several practical prototypes of tightly coupled arrays are fabricated using the typical FR4 printed-circuit-board (PCB) fabrication process. The prototypes are measured in several indoor scenarios at the presence of multipath. The results are studied in detail.
Panepophenanthrin, from a Mushroom Strain, a Novel Inhibitor of the Ubiquitin-Activating Enzyme (2002)

Screening for inhibitors of the ubiquitin-proteasome pathway, considered to regulate important cellular events and linked to serious diseases as well, led to isolation of a new compound, panepophenanthrin, from the fermented broth of a mushroom strain, Panus rudis Fr. IFO 8994. This is the first inhibitor of the ubiquitin-activating enzyme, which is indispensable for the ubiquitin-proteasome pathway. The structure of panepophenanthrin was determined by NMR and X-ray crystallographic analyses as 1,3a,10-trihydroxy-10c-(3-hydroxy-3-methylbut-1-enyl)-5,5-dimethyl-1,2,3,3a,5,5a,8,9,10,10a,10b,10c-dodecahydro-4-oxa-2,3,8,9-diepoxyacephenanthrylen-7-one.
SNBENCH: a development and run-time platform for rapid deployment of sensor network applications (2005)

We envision the emergence of general-purpose, well-provisioned sensor networks - which we call "Sensoria" - that are embedded in (or overlayed atop) physical spaces, and whose use is shared amongst autonomous users of that space for independent and possibly conflicting missions. Our conception of a Sensorium stands in sharp contrast to the commonly adopted view of an embedded sensor network as a special-purpose infrastructure that serves a well-defined, fixed mission. The usefulness of a Sensorium will not be measured by how highly optimized its various protocols are, or by how efficiently its limited resources are being used, but rather by how flexible and extensible it is in supporting a wide range of applications. To that end, in this paper, we overview and present a first-generation implementation of SNBENCH: a programming environment and associated run-time system that support the entire life-cycle of programming sensing-oriented applications. The components of SNBENCH are analogous to those commonly found in traditional, stand-alone general-purpose computing environments. SNAFU (sensornet applications as functional units) is a high-level strongly-typed functional language that supports stateful, temporal, and persistent computation. SNAFU is compiled into an intermediate, abstract representation of the processing graph, called a STEP (Sensorium task execution plan). The STEP graph is then linked to available Sensorium execution environments (SXEs). A Sensorium service dispatcher (SSD) decomposes the STEP graph into a linked execution plan, loading STEP sub-graphs to appropriate individual SXEs and binding those loaded sub-graphs together with appropriate network protocols. The SSD may load many such programs onto a Sensorium simultaneously, taking advantage of programs' shared computation and dependencies to make more efficient use of sensing, computation, network, and storage resources
Human immunodeficiency virus reverse transcriptase. Expression in Escherichia coli, purification, and characterization of a functionally and structurally asymmetric dimeric polymerase (1993)

Human immunodeficiency virus (HIV) reverse transcriptase isolated from viral particles contains two subunits, p51 and p66. We have produced both subunits in separate Escherichia coli strains using expression vectors. Stop codons were placed immediately after the codon for the carboxyl-terminal residue of the mature processed p51 and p66 subunits found in viral particles. Insertion of a methionine in front of the HIV protease cleavage site in the recombinant protein enabled synthesis of both subunits with the natural amino-terminal proline, since E. coli methionine aminopeptidase cleaves a Met-Pro amino-terminal linkage. That this occurred to an extent greater than 95% was confirmed by sequencing the purified subunits. Examination of the activities of the individual p51 and p66 subunits on a variety of templates and under solution conditions optimized for each subunit revealed a significant catalytic activity for the natural p51 subunit. This result contrasts to results reported earlier for many recombinant forms without the natural amino and/or carboxyl termini. As expected from earlier work, the optimal homopolymeric template for the p66 subunit was poly(rA). For the p51 subunit, poly(dC) was found to be the optimal template; its activity is 2- to 4-fold greater than p66 on poly(dC). The p51 subunit is 13- to 50-fold less active on poly(rC). These findings are discussed in the context of our earlier hypothesis (McHenry, C. S. (1989) in Molecular Biology of Chromosome Function (Adolph, K., ed) Chap. 5, Springer-Verlag, New York) that the HIV reverse transcriptase might be functionally asymmetric with distinct plus- and minus-strand polymerases.
Induced terminal differentiation and tumorigenic suppression in murine keratinocyte somatic‐cell hybrids (1995)

The development of malignancy has been associated with both the activation of oncogenes and the inactivation of tumor suppressor genes. Whereas recent data implicate tumor suppressor genes as cell-cycle check-points, the nature and timing of tumor suppressor gene inactivation during multistage carcinogenesis is still largely uncharacterized. To address this issue, we used a syngeneic mouse epidermal model system. By creating somatic-cell hybrids between nontumorigenic x benign (291 x 291.09RAT), nontumorigenic x malignant (291 x 291.05RAT and 291 x 291.03RAT), benign x malignant (291.09RAT x 291.03RAT) and malignant x malignant (291.03RAT x 291.05RAT) clones, multiple tumor suppressor activities were detected. Most importantly, we demonstrated the first example of the complete suppression of benign papillomas in vivo, thus implicating tumor suppressor gene activity loss an early event in skin carcinogenesis. In addition, the carcinoma phenotype was suppressed in vivo by nontumorigenic, benign, and heterologous malignant keratinocytes. The somatic-cell hybrids expressed the differentiation-specific keratins, K1 and K10, in response to high extracellular calcium concentrations (1.4 mM) in vitro. All of the hybrids had fewer local metastases than did the parental lines, and when tumor formation was not suppressed, the resulting tumors were highly differentiated. Polymerase chain reaction analysis of the neomycin-resistance gene at nontumorigenic injection sites indicated an absence of injected hybrids, and subsequent analyses failed to detect nontumorigenic 291 cells 1 wk after transplantation. These data demonstrate that distinct tumor suppressor gene activities are lost at discrete stages during multistage carcinogenesis and are consistent with the hypothesis that tumor suppression can occur through induction of terminal differentiation.
Resolution and DOF improvement through the use of square-shaped illumination (1999)

As optical lithography is pushed to smaller dimensions, methods of resolution enhancement are considered necessary. Illumination modification is getting a good deal of attention, through strong and weak off-axis methods. The shape of an illumination profile does not need to be circular, especially if X/Y feature orientation is considered. This paper describes the improvements in imaging that are possible through use of source shapes that have various degrees of square character. Applications are discussed and interaction with optical proximity correction, aberration, and other imagin factors are addressed.
Secure Residential Gateways: OSGi services with Java Cards (2006)

This work proposes an integration of Smart Cards into a Residential Gateway. The aim is to extend services offered by the gateway with the functionalities provided by the Smart Card. Thanks to this integration, functionalities like cryptographic services, secure payments for pay-per-view or environment's customization can be made available. The core of this work has been carried out in order to achieve an integration for two existing technologies: The Open Services Gateway Initiative (OSGi) and Java Card.
Handbook of Assay Development in Drug Discovery (2006)

Handbook of assay development in drug discovery , Handbook of assay development in drug discovery , کتابخانه دیجیتال جندی شاپور اهواز
Modeling and Analyzing Millimeter Wave Cellular Systems (2016)

We provide a comprehensive overview of mathematical models and analytical techniques for millimeter wave (mmWave) cellular systems. The two fundamental physical differences from conventional sub-6-GHz cellular systems are: 1) vulnerability to blocking and 2) the need for significant directionality at the transmitter and/or receiver, which is achieved through the use of large antenna arrays of small individual elements. We overview and compare models for both of these factors, and present a baseline analytical approach based on stochastic geometry that allows the computation of the statistical distributions of the downlink signal-to-interference-plus-noise ratio (SINR) and also the per link data rate, which depends on the SINR as well as the average load. There are many implications of the models and analysis: 1) mmWave systems are significantly more noise-limited than at sub-6 GHz for most parameter configurations; 2) initial access is much more difficult in mmWave; 3) self-backhauling is more viable than in sub-6-GHz systems, which makes ultra-dense deployments more viable, but this leads to increasingly interference-limited behavior; and 4) in sharp contrast to sub-6-GHz systems cellular operators can mutually benefit by sharing their spectrum licenses despite the uncontrolled interference that results from doing so. We conclude by outlining several important extensions of the baseline model, many of which are promising avenues for future research.
The ban operon of bacteriophage P1. Localization of the promoter controlled by P1 repressor. (1987)

Repression of a strong promoter localized 5' to the P1 ban gene is a prerequisite for cloning the ban operon in the multicopy plasmid pBR325. Repression is brought about by the binding of P1 repressor to the operator of the ban operon (Heisig, A., Severin, I., Seefluth, A. K., and Schuster, H. (1987) Mol. Gen. Genet. 206, 368-376). Binding of RNA polymerase in vitro overlaps with the operator and is inhibited by P1 repressor as shown by electron microscopy. The mutant P1 bac, which renders ban expression constitutive, contains a single base pair exchange within the operator. As a consequence, more repressor is required (i) for the inhibition of binding of RNA polymerase, and (ii) for the electrophoretic retardation of a P1 bac DNA fragment when compared to the corresponding bac+ fragment. A P1 ban recombinant plasmid containing a 4-base pair deletion close to the operator still allows binding of repressor but not of RNA polymerase. By that means, a repressible promoter is located at the P1 map position 72 in a distance of about 2.5 kilobase pairs to the beginning of the ban gene.
Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease (1998)

Glutamic acid decarboxylase (GAD)65 is a pancreatic beta cell autoantigen implicated as a target of T cells that initiate and sustain insulin-dependent diabetes mellitus (IDDM) in humans and in non-obese diabetic (NOD) mice. In an attempt to establish immunological tolerance toward GAD65 in NOD mice, and thereby to test the importance of GAD in IDDM, we generated three lines transgenic for murine GAD65 driven by a major histocompatibility complex class I promoter. However, despite widespread transgene expression in both newborn and adult mice, T cell tolerance was not induced. Mononuclear cell infiltration of the islets (insulitis) and diabetes were at least as bad in transgenic mice as in nontransgenic NOD mice, and in mice with the highest level of GAD65 expression, disease was exacerbated. In contrast, the same transgene introduced into mouse strain, FvB, induced neither insulitis nor diabetes, and T cells were tolerant to GAD. Thus, the failure of NOD mice to develop tolerance toward GAD65 reflects at minimum a basic defect in central tolerance, not seen in animals not predisposed to IDDM. Hence, it may not be possible experimentally to induce full tolerance toward GAD65 in prediabetic individuals. Additionally, the fact that autoimmune infiltration in GAD65 transgenic NOD mice remained largely restricted to the pancreas, indicates that the organ-specificity of autoimmune disease is dictated by tissue-specific factors in addition to those directing autoantigen expression.
Multiplex Lateral Flow Immunoassay for Mycotoxin Determination (2014)

A new lateral flow immunoassay (LFA) is proposed for qualitative and/or semiquantitative determination of aflatoxin B1 (AFB1), zearalenone (ZEA), deoxynivalenol (DON), and their analogues (AFs, ZEAs, DONs) in cereal samples. Each of the mycotoxin specific antibody was class specific and there was no cross reactivity to other groups of compounds. The visual limits of detection (vLOD) of the strip were 0.03, 1.6, and 10 μg/kg for AFB1, ZEA and DON, respectively. The calculated limits of detection (cLOD) were 0.05, 1, and 3 μg/kg, respectively. Meanwhile the cutoff values were achieved at 1, 50, and 60 μg/kg for AFB1, ZEA and DON, respectively. Recoveries ranged from 80% to 122% and RSD from 5% to 20%. Both the vLOD and cLOD for the three mycotoxins were lower than the EU maximum levels. Analysis of naturally contaminated maize samples resulted in a good agreement between the multiplex LFA and LC-MS/MS (100% for DONs and AFs, and 81% for ZEAs). Careful analysis of the results further explained the general overestimation of LFA compared to chromatographic methods for quantification of mycotoxins.
Measuring the anisotropic thermal diffusivity of silicon nitride grains by thermoreflectance microscopy (1999)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Bincheng Li, L. Pottier, J. P. Roger, D. Fournier, K. Watari, K. Hirao; Measuring the anisotropic thermal diffusivity of silicon nitride grains by thermoreflectance microscopy. AIP Conf. Proc. 15 March 1999; 463 (1): 371–373. https://doi.org/10.1063/1.58085 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Detection of a glycosylation-dependent ligand for the T lymphocyte cell adhesion molecule CD2 using a novel multimeric recombinant CD2-binding assay (1993)

The CD2 molecule plays an important role in T cell adhesion by interacting with the ligands CD58 (LFA-3) and CD59. In order to detect additional ligands for CD2, potentially of low binding affinity, we have prepared a highly fluorescent, multimeric form of rCD2 whose binding to cells can be quantified by flow cytometry. Initial studies demonstrated that binding of multimeric rCD2 to cells was CD2-specific, concentration and time dependent, and saturable. The negative charge on cells was also found to play a critical role in the efficiency of multimeric rCD2 binding. Analysis of binding of multimeric rCD2 to 17 CD58+ cell types revealed that only 8 of the cells exhibited binding. Failure of multimeric rCD2 to interact with the other cells could not be explained by differences in CD58 expression, suggesting that, in terms of CD2 binding, there are qualitative differences in CD58 on different cell types. Binding of multimeric rCD2 to six of the seven reactive cells was virtually totally inhibited by CD58 mAb pretreatment, whereas binding to the erythroleukemic line K562 was only partially blocked, suggesting the existence of another CD2 ligand. Subsequent studies demonstrated that the putative new ligand is not CD59, and that it interacts with a different region of the CD2 molecule than CD58, probably a site located between the T11(1) and T11(2) epitopes. The binding affinity of CD2 for the new ligand is 10-fold lower than for CD58 and, based on studies with truncated rCD2, the binding site for the new ligand is located within the amino-terminal 105 amino acids of the CD2 polypeptide. Unlike CD58, the new ligand is tunicamycin sensitive suggesting that it contains a N-linked carbohydrate structure that is essential for functional activity.
Estudio de prevalencia y demanda médica por cefalea en la población laboral de correos (2004)

espanolObjetivos. Conocer la prevalencia de dolor de cabeza, la demanda medica y los niveles de satisfaccion con esta consulta entre los empleados de Correos. Sujetos y metodos. Estudio observacional transversal basado en una encuesta enviada a 61.665 trabajadores de Correos distribuidos en 51 provincias espanolas (35% en zonas urbanas y 65% en zonas rurales). La edad media era de 43,5 anos y el 63% eran hombres. La encuesta se envio durante el periodo 2001-2002, junto a la nomina, y contenia tres preguntas sobre la existencia de dolor de cabeza, la demanda medica por este motivo y la satisfaccion obtenida. Los resultados se evaluaron por grupos de edad, sexo, puestos de trabajo y distribucion geografica. Resultados. La respuesta obtenida fue del 15,9%, (9.832 personas), mas elevada entre las mujeres (53%). La edad media entre los que contestaron fue de 41,4 anos para las mujeres y 44,4 para los hombres. La prevalencia de dolor de cabeza obtenida fue del 34% (53% en las mujeres y 47% en los hombres). La demanda medica asistencial fue del 61% (72% en las mujeres y 57% en los hombres). El 35% de los trabajadores estaban satisfechos con la asistencia recibida previamente a nuestro estudio de intervencion. Conclusiones. En relacion con la prevalencia obtenida, el nivel de consulta medica es aun bajo, y la insatisfaccion alta entre los pacientes. Es necesario incrementar la asistencia medica y la informacion sobre la patologia entre los trabajadores en nuestro medio laboral. Igualmente, es necesario incrementar la formacion continuada general y en salud laboral del personal sanitario. EnglishObjective: to discover the prevalence of headache, medical requirement and satisfaction levels with this consultancy among the employees of the Spanish Post Office. Subjects and methods: this is a transversal-observational study based on a survey that was sent to 61,665 post office employees, from 51 Spanish provinces (35% in cities and 65% in the rural areas).The average age was 43.5 and 63% were men. The survey was sent during the period covering 2001-2002 with the survey containing 3 questions about the existence of headache, medical requirement for headache and satisfaction obtained. Results were evaluated by age groups, jobs involved and geographical distribution. Results: The response rate was 15.9% (9,832 people), the response rate being higher among women (53%), and the mean age was 41.4 years for women and 44.4 for men. Prevalence of headache was 34%, women 53% and men 47%. Demand for medical care was 61%: women 72% and men 57%. 35% of employees were satisfied with the medical care obtained, 65% were notbefore our interventional study. Conclusions. in relation to the prevalence obtained, the rate of consultations is still low, and unsatisfaction rate high among patients. In our working environment it is necessary to improve medical care and information given to the employees about this pathology. At the same time it is necessary to increase the continuity in general medical training and occupational health training in doctors and nurses.