gebhart/patrepeval huggingface dataset:
Evidence for translated intervening sequences in the mitochondrial genome of Saccharomyces cerevisiae. (1982)

In yeast, the mitochondrial genes for subunit I of cytochrome oxidase (oxi3) and for apocytochrome b (cob) are known to be split. In some strains, the latter contains five intervening sequences, three of which coincide with clusters of mutational sites referred to in their order of transcription as the loci box3, 10, and 7, respectively. Mutations at the first of these result in the accumulation of novel, large polypeptides (apparent Mr congruent to 43,000) believed to originate from a fusion of sequences found in the NH2-terminal segment of apocytochrome b to others encoded in the intervening sequence itself. We now provide evidence for close similarities of at least a part of translated intron sequences between (a) mutants in box7 in "long" form and "short" form strains (which lack the first three introns including the one for the box3 locus); (b) mutants in a subset of box7 mutants and those in box3, and (c) between intron sequences in box7 and a sequence presumably encoded in oxi3. These structural homologies have been analyzed and shown to be referable to sequence homologies in two proteins, one derived from the second intron (box3) in cob and the other from oxi3. The accumulation in certain cob mutants of proteins and of a transcript containing a sequence specified by oxi3 provides additional strong evidence for the previously suggested regulation of oxi3 by the penultimate, box7-containing intron of cob.
Towards MPEG-4 part 10 system on chip: a VLSI prototype for contextbased adaptive variable length coding (CAVLC) (2004)

The paper presents a VLSI prototype for context-based adaptive variable length coding (CAVLC). This scheme is a part of the lossless compression process in the MPEG-4 Part 10 standard. It is applied to the quantized transform coefficients of the luminance component during the entropy coding process. In combination with previous transformations and quantizations, it can result in significantly increased compression ratio. The developed architecture is prototyped and simulated using ModelSim 5.4/spl reg/. It is synthesized using Synplify Pro 7.1/spl reg/. The results show that the architecture satisfies the real-time constraints required by different digital video applications.
Patterned DNA Metallization by Sequence-Specific Localization of a Reducing Agent (2004)

Localization of a reducing agent, glutaraldehyde, on DNA molecules directs their metallization into highly conductive wires. DNA can be marked for metallization by aldehyde derivatization while retaining its biological functionality. Patterning the aldehyde derivatization of the DNA molecules in a sequence-specific manner allows to embed the precise metallization pattern into the DNA scaffold without compromising its recognition capabilities or biological functionality. We demonstrate scaffold DNA patterning by hybridization of aldehyde-derivatized and underivatized DNA molecules and by sequence-specific protection against aldehyde derivatization. This approach opens new possibilities in wiring of complex molecular-scale electronic circuits.
Photostimulated reaction of diphenylarsenide and diphenylstibide ions with haloaromatic compounds by the SRN1 mechanism. Electron transfer vs. bond breaking of the radical anion intermediate (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotostimulated reaction of diphenylarsenide and diphenylstibide ions with haloaromatic compounds by the SRN1 mechanism. Electron transfer vs. bond breaking of the radical anion intermediateRuben A. Alonso and Roberto A. RossiCite this: J. Org. Chem. 1982, 47, 1, 77–80Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/jo00340a016https://doi.org/10.1021/jo00340a016research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quantitative Anatomy of Cervical Spine Ligaments. Part I. Upper Cervical Spine (1991)

The quantitative anatomy of the ligaments of the upper cervical spine was determined from six human cadaveric specimens. For the apical, transverse, and alar ligaments, the origins, lengths, and orientations were determined in three-dimensional space. The apical ligament was 23.5 (3.8) mm long with a 20 degrees anterior tilt from the frontal plane. The transverse ligament was 21.9 (3.7) mm long, whereas the alar ligaments averaged 10.3 (2.0) mm in length. The alar ligaments were oriented 70 degrees from the sagittal plane with much variation in its angle with both the frontal and transverse planes.
Retina and Vitreous (1994)

The normal retina and vitreous diagnostic tests retinal disorders disorders of the vitreous.
Quetiapine fumarate (Seroquel(R)): A new atypical antipsychotic (1999)

The goal of antipsychotic drug development efforts over the past 10 years has been to develop agents with increased efficacy and safety and fewer of the side effects commonly associated with the older antipsychotic medications. The newer agents, often called atypical antipsychotics, are effective in treating both the positive and negative symptoms of schizophrenia and are associated with fewer neurological- and endocrine-related side effects compared to the older agents. As a result, patients are likely to remain on therapy longer, preventing relapses and costly hospitalizations. Quetiapine fumarate (Seroquel) is the most recently introduced atypical antipsychotic and is indicated for the management of the manifestations of psychotic disorders and schizophrenia. Quetiapine, like clozapine (the archetypal atypical antipsychotic), interacts with a broad range of neurotransmitter receptors and has a higher affinity for serotonin (5-HT(2A)) receptors relative to dopamine (D(2)) receptors in the brain. Further, quetiapine's pharmacological effects appear selective for the mesolimbic and mesocortical dopamine systems, which are believed to be the areas of the brain responsible for the therapeutic effects of antipsychotics. In contrast to most standard antipsychotics and some atypical antipsychotics, quetiapine's effects on the nigrostriatal dopamine system, which is responsible for the extrapyramidal (or motor) side effects, are minimal. Quetiapine also has minimal activity on dopamine receptors in the tuberoinfundibular dopamine system, thereby avoiding the problem of hyperprolactinemia, common with the standard antipsychotics and some atypical antipsychotics. Because of these properties, quetiapine is an effective antipsychotic agent with a relatively benign side effect profile. Several large, placebo- and active-controlled, multicenter trials have shown quetiapine to be effective against both positive (e.g., hallucinations, delusions) and negative symptoms (e.g., emotional withdrawal, apathy) and to have benefits in reducing hostility, aggression and affective symptoms. Patients on long-term treatment report high compliance, good satisfaction, increased ability to function and improvements consistent with a better quality of life. Because of quetiapine's excellent tolerability profile, its use is particularly appropriate in patients especially sensitive to adverse effects, e.g., elderly patients with psychotic symptoms and other neurological disorders such as Parkinson's and Alzheimer's disease.
Panther (1986)

An experimental graphical control specification system, called Panther, has been written in C for UNIX®-based applications. Unlike similar systems, which focus on combining interaction techniques, Panther allows the specification of low-level interactions by invoking user-selectable subroutines for input-device transitions. A Panther interface is specified in a textual table as a set of hierarchically nested regions . Regions can model any control device, such as menu buttons, slider-bars, switches, alphanumeric displays, or even combinations of other regions. Panther does not rely on special hardware, extensive software, or interprocess communication.
Deinococcus aquatilis sp. nov., isolated from water (2008)

A pale-pink strain (CCUG 53370(T)) from water was investigated by a polyphasic taxonomic approach. The cells stained Gram-positive and were rod-shaped and non-spore-forming. Analyses using the 16S rRNA gene sequence of the isolate showed that the organism belongs to the genus Deinococcus, with the highest sequence similarities to the type strains of Deinococcus ficus (94.4 %), Deinococcus navajonensis (94.3 %) and Deinococcus mumbaiensis (94.3 %). Chemotaxonomic data revealed that CCUG 53370(T) contains exclusively menaquinone MK-8 as the respiratory quinone and a complex polar lipid profile consisting of different unidentified glycolipids and polar lipids, two unknown phospholipids and three unknown phosphoglycolipids. As in other deinococci, one of these phosphoglycolipids was predominant in the profile, and it was identified in Deinococcus radiodurans as 2'-O-(1,2-diacyl-sn-glycero-3-phospho)-3'-O-(alpha-galactosyl)-N-D-glyceroyl alkylamine. Predominant fatty acids were C(16 : 1)omega7c, C(17 : 1)omega8c and C(17 : 1)omega9c. Biochemical and chemotaxonomic properties demonstrate that strain CCUG 53370(T) represents a novel species, for which the name Deinococcus aquatilis sp. nov. is proposed. The type strain is CCUG 53370(T) (=CCM 7524(T)).
Remote measurements of ambient air pollutants with a bistatic laser system (1976)

The ambient air pollutants ozone, nitric oxide, and ethylene have been monitored in the Pasadena area with a bistatic ir laser apparatus. These pollutants were measured with a differential absorption technique using selected wavelengths in the 9.5-microm, 5.2-microm, and 10.5-mum regions, respectively. The transmitted laser radiation was detected using both direct and heterodyne detection techniques. In the direct detection case cube corner retroreflectors provided the return, and the heterodyne detection responded to scattered radiation from various rough surfaces, ranging from 400 m to 1.9 km in distance from the apparatus. Significant departures from ambient background concentration levels were noticed in the region near a local freeway during periods of moderate and heavy traffic.
Effect of Secondary Structure on Single Nucleotide Polymorphism Detection with a Porous Microarray Matrix; Implications for Probe Selection (2003)

Oligonucleotide arrays capable of detecting single nucleotide polymorphisms (SNPs) from amplified nucleic acid have many applications. The expected SNP is usually placed approximately in the center of the probe to ensure the maximum shift in Tm between complementary and SNP sequences. Unfortunately, different short probes (< 30 bases) selected using widely accepted criteria do not perform consistently in this type of assay. Here we present a systematic study on the effect of secondary structure on the ability of oligonucleotide probes to detect an SNP, using real-time array monitoring of a porous microarray substrate that incorporates a novel intra-array mixing system. These results demonstrate that, although positioning of an SNP in the middle of the probe is highly destabilizing, the effect of stable secondary structure on the signal obtained is so dramatic that such probes may be very insensitive. Therefore, if the SNP flanking sequence contains significant secondary structure, then more sensitive probes with good specificity may be obtained by positioning the mutation towards one end of the probe.
Computer Vulnerability Analysis: Thesis Proposal (1997)

Computer security professionals and researchers do not have a history of sharing and analyzing computer vulnerability information.Scientists and engineers from older or more established fields have long understood that publicizing, analyzing, and learning from other people's mistakes is essential to the stepwise refinement of complex systems.Computer scientists, however, have not followed suit.Programmers reinvent classical programming mistakcs, contributing to the reappearance of known vulnerabilities.In the recent past, complltcr systems have come to be a part of critical systems that have a direct effect on the safety and well-being of human beings and hence we must have lower tolerance for software failures.In the dissedation I will attempt to show that computer vulnerability information presents important regularities and these can be detected, and possibly visualized, providing important insight about the reason of their prevalence and existence.The information derived from these observations could be used to improve on all phases of the development of software systems, as could be in the design, development, debugging, testing and maintenance of complex computer systems that must implement a set of policies defined by security analysis.A significant portion of the work that must be performed will concentrate on the development of clilSSifications and taxonomies that will permit the visualization and analysis of computer vulnerability information.I hope that these classifications and taxonomies applied to a collection of vulnerabilities will provide a set of features whose analysis will show that there arc clear statistical clustering:; and patterns caused because developers and programmers are not learning from each others mistakes.Tlti.s analysis may be performed by applying statistical analysis and knowledge discovery tools.1.In
Developing a distributed architecture for design rule checking (2002)

This paper describes the design and implementation of a distributed object-oriented design rule checker (DRC). The main focus is on the methodology employed to implement this distributed application. Code reusability is achieved using an OO approach, making objects available for other tools, such as circuit extractor. The paper also addresses the application of design patterns, which produce loosely coupled elements, facilitating the integration of system modules.
Low-Cost Testers: Are They Really Low Cost? (1985)

Initial ATE capital investments can affect overall test manufacturing costs as shown in this analysis, which compares a $5000 semiconductor tester with a $900,000 system (purchase price). The application is wafer testing of logic die, and the product has a five-year lifetime. Variables affecting cost include tester throughput, wafer test escape rate, and test system capital cost. Factors considered in the analysis include (1) the number of test systems required and the cost effect of capital, floor space, and manpower, (2) the quality of test and the effect of escapes on subsequent manufacturing operations; and (3) the effects of tax credits on the two options. Results of the comparison show that a major factor is escape from wafer test. Even a low escape rate justifies the use of the $900,000 general-purpose system over the $5000 low-cost tester. Throughput differences also tend to negate any initial cost advantage with the LCT. When total systems are considered (four LCTs are needed over the five years), total capital costs tend to converge. A major asset of the GPT is its flexibility, making it again more attractive than the LCT.
Studies on the Growth of Citrus Seedlings with Different Forms of Nitrogen in Solution Cultures. (1957)

Citrus has
Aconitase Couples Metabolic Regulation to Mitochondrial DNA Maintenance (2005)

Mitochondrial DNA (mtDNA) is essential for cells to maintain respiratory competency and is inherited as a protein-DNA complex called the nucleoid. We have identified 22 mtDNA-associated proteins in yeast, among which is mitochondrial aconitase (Aco1p). We show that this Krebs-cycle enzyme is essential for mtDNA maintenance independent of its catalytic activity. Regulation of ACO1 expression by the HAP and retrograde metabolic signaling pathways directly affects mtDNA maintenance. When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance.
Abstract 1732: Synthesis and evaluation of NSC23925 isomers to reverse multidrug resistance in cancer (2011)

Abstract The eventual development of multidrug resistance (MDR) during the course of chemotherapy treatment is a fundamental obstacle associated with cancer care. Prior studies have identified NSC23925 ((2-(4-methoxyphenyl)-4-quinolinyl) (2-piperidinyl) methanol)) to be a small molecule agent that reverses MDR in cancer cells. Analysis of the structure of NSC23925 indicates that NSC23925 has two chiral centers which lead to 4 different stereo-isomers (erythro-7a, threo-7b, threo-9a and erythro-9b). Each isomer may or may not have distinct bio-activity from the others. In this study, we synthesized all four isomers of NSC23925 and analyzed by liquid chromatography-mass spectrometry (LCMS, HPLC-MS). Structure and activity relationships for reversing MDR in several MDR human cancer cell lines were evaluated by MTT assay. We observed that compound erythro-9b (NSC23925-9b) is the most potent isomer on reversing drug resistance, threo-7b and threo-9a also showed modest but lesser activity, and Erythro-7a showed the least potency. NSC23925-9b is able to reverse MDR in several drug resistant cell lines expressing Pgp in vitro, including ovarian, breast, colon, and sarcoma cancer cell lines. NSC23925-9b was able to re-sensitize these cell lines to paclitaxel, doxorubicin, vincristine and ET-743 with no effect on cell sensitivity to cisplatin, topotecan and methotrexate. NSC23925-9b was unable to reverse drug resistance in non-Pgp expressing drug resistant cell lines. Furthermore, NSC23925-9b significantly enhanced in vivo antitumor activity of paclitaxel in MDR ovarian cancer cell line SKOV-3TR xenograft models, without significant increasing the level of paclitaxel toxicity. In conclusion, these results demonstrated that NSC23925-9b and derivatives of this compound may hold therapeutic value in the treatment of MDR dependent cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1732. doi:10.1158/1538-7445.AM2011-1732
Distribution System Voltage Performance Analysis for High-Penetration Photovoltaics (2008)

This report examines the performance of commonly used distribution voltage regulation methods under reverse power flow.
New micro-beam beamline at SPring-8, targeting at protein micro-crystallography (2010)

A new protein micro‐crystallography beamline BL32XU at SPring‐8 is under construction and scheduled to start operation in 2010. The beamline is designed to provide the stabilized and brilliant micro‐beam to collect high‐quality data from micro‐crystals. The beamline consists of a hybrid in‐vacuum undulator, a liquid‐nitrogen cooled double crystal monochromator, and K‐B focusing mirrors with large magnification factor. Development of data acquisition system and end station consists of high‐precision diffractometer, high‐efficiency area detector, sample auto‐changer etc. are also in progress.
A network interface for real-time video services on a high-speed multimedia LAN (1992)

The authors present a method to integrate the uncompressed real time video data into high-speed multimedia LAN. They use a buffer insertion ring twisted-pair LAN to transfer the data. The video data will be transferred 30 frames/sec to get good video quality. A priority control scheme will make most of the real time data served first. It guarantees that the transmission delay falls into a tolerable range. A real-time input-buffer control scheme will always remove the oldest packet(s) instead of using input buffer limit (IBL) flow control. The authors also develop a user interface to make the system easier to operate. The system's complexity is hidden by the user interface.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cash benefits for short-term sickness: thirty-five years of data, 1948-83. (1986)

*Office of Research, Statistics, and International Policy, Office of Policy. Social Security Administration. made to replace such lost income totaled $16.4 billion, or 36 percent of the loss. This degree of protection against income loss from short-term sickness has been about the same since 1970. The number of workers protected by formal plans providing cash benefits for sickness in 1983 rose to 59 million, or almost twothirds of all wage and salary workers, a reflection of the economic upswing during that year.
USING LONGEST-SIDE BISECTION TECHNIQUES FOR THE AUTOMATIC REFINEMENT OF DELAUNAY TRIANGULATIONS (1997)

In this paper we discuss, study and compare two linear algorithms for the triangulation refinement problem: the known longest-side (triangle bisection) refinement algorithm, as well as a new algorithm that uses longest side bisection techniques for refining Delaunay triangulations. We show that the automatic point insertion criterion, taken from the fractal property of optimal (linear) longest-side bisection algorithms, assures the construction of good quality Delaunay triangulations in linear time. Numerical evidence, showing that the practical behaviour of the new algorithm is in complete agreement with the theory, is included. © 1997 by John Wiley & Sons, Ltd.
Cloning and Expression of an Oligopeptidase, PepO, with Novel Specificity from <i>Lactobacillus rhamnosus</i> HN001 (DR20) (2002)

Oligopeptidases of starter and nonstarter lactic acid bacteria contribute to the proteolytic events important in maturation and flavor development processes in cheese. This paper describes the molecular cloning, expression, and specificity of the oligopeptidase PepO from the probiotic nonstarter strain Lactobacillus rhamnosus HN001 (DR20). The pepO gene encodes a protein of 70.9 kDa, whose primary sequence includes the HEXXH motif present in certain classes of metallo-oligopeptidases. The pepO gene was cloned in L. rhamnosus HN001 and overexpressed in pTRKH2 from its own promoter, which was mapped by primer extension. It was further cloned in both pNZ8020 and pNZ8037 and overexpressed in Lactococcus lactis subsp. cremoris NZ9000 from the nisA promoter. The purified PepO enzyme demonstrated unique cleavage specificity for alpha(s1)-casein fragment 1-23, hydrolyzing the bonds Pro-5-Ile-6, Lys-7-His-8, His-8-Gln-9, and Gln-9-Gly-10. The impact of this enzyme in cheese can now be assessed.