gebhart/patrepeval huggingface dataset:
rac-[Ethylidene(1-.eta.5-tetramethylcyclopentadienyl)(1-.eta.5-indenyl)]dichlorotitanium and its homopolymerization of propylene to crystalline-amorphous block thermoplastic elastomers (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTrac-[Ethylidene(1-.eta.5-tetramethylcyclopentadienyl)(1-.eta.5-indenyl)]dichlorotitanium and its homopolymerization of propylene to crystalline-amorphous block thermoplastic elastomersDaniel T. Mallin, Marvin D. Rausch, Ye Gang Lin, Sizhong Dong, and James C. W. ChienCite this: J. Am. Chem. Soc. 1990, 112, 5, 2030–2031Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/ja00161a075https://doi.org/10.1021/ja00161a075research-articleACS PublicationsRequest reuse permissionsArticle Views481Altmetric-Citations219LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Definition of Core Requirements and a Reference Architecture for a Dependable, Secure and Adaptive Distributed Monitoring Framework (2010)

This paper discusses different aspects of performing monitoring in the context of software intensive systems. The focus is especially on cases where the observed system is distributed, and the monitoring system needs to be secure, dependable and capable to adapt to a number of dynamic scenarios during the system evolution. Based on analysis of monitoring needs in this type of a domain, a set of core requirements for providing a monitoring framework for these domains are defined. To address these requirements, a high-level reference architecture for a monitoring framework is presented. Together these provide a basis for designing different monitoring frameworks.
Increased IL‐17A secretion in response to <i>Candida albicans</i> in autoimmune polyendocrine syndrome type 1 and its animal model (2010)

Autoimmune polyendocrine syndrome type 1 (APS-1) is a multiorgan autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal failure are hallmarks of the disease. The critical mechanisms causing chronic mucocutaneous candidiasis in APS-1 patients have not been identified although autoantibodies to cytokines are implicated in the pathogenesis. To investigate whether the Th reactivity to Candida albicans (C. albicans) and other stimuli was altered, we isolated PBMC from APS-1 patients and matched healthy controls. The Th17 pathway was upregulated in response to C. albicans in APS-1 patients, whereas the IL-22 secretion was reduced. Autoantibodies against IL-22, IL-17A and IL-17F were detected in sera from APS-1 patients by immunoprecipitation. In addition, Aire-deficient (Aire(0/0) ) mice were much more susceptible than Aire(+/+) mice to mucosal candidiasis and C. albicans-induced Th17- and Th1-cell responses were increased in Aire(0/0) mice. Thus an excessive IL-17A reactivity towards C. albicans was observed in APS-1 patients and Aire(0/0) mice.
The viral manipulation of the host cellular and immune environments to enhance propagation and survival: a focus on RNA viruses (2002)

Virus infection presents a significant challenge to host survival. The capacity of the virus to replicate and persist in the host is dependent on the status of the host antiviral defense mechanisms. The study of antiviral immunity has revealed effective antiviral host immune responses and enhanced our knowledge of the diversity of viral immunomodulatory strategies that undermine these defences. This review describes the diverse approaches that are used by RNA viruses to trick or evade immune detection and response systems. Some of these approaches include the specific targeting of the major histocompatibility complex-restricted antigen presentation pathways, apoptosis, disruption of cytokine function and signaling, exploitation of the chemokine system, and interference with humoral immune responses. A detailed insight into interactions of viruses with the immune system may provide direction in the development of new vaccine strategies and novel antiviral compounds.
Gadolinium-conjugated PLA-PEG nanoparticles as liver targeted molecular MRI contrast agent (2010)

A nanoparticle magnetic resonance imaging (MRI) contrast agent targeted to liver was developed by conjugation of gadolinium (Gd) chelate groups onto the biocompatible poly(l-lactide)-block-poly (ethylene glycol) (PLA-PEG) nanoparticles. PLA-PEG conjugated with diethylenetriaminopentaacetic acid (DTPA) was used to formulate PLA-PEG-DTPA nanoparticles by solvent diffusion method, and then Gd was loaded onto the nanoparticles by chelated with the unfolding DTPA on the surface of the PLA-PEG-DTPA nanoparticles. The mean size of the nanoparticles was 265.9 ± 6.7 nm. The relaxivity of the Gd-labeled nanoparticles was measured, and the distribution in vivo was evaluated in rats. Compared with conventional contrast agent (Magnevist), the Gd-labeled PLA-PEG nanoparticles showed significant enhancement both on liver targeting ability and imaging signal intensity. The T(1) and T(2) relaxivities per [Gd] of the Gd-labeled nanoparticles was 18.865 mM(-1) s(-1) and 24.863 mM(-1) s(-1) at 3 T, respectively. In addition, the signal intensity in vivo was stronger comparing with the Gd-DTPA and the T(1) weight time was lasting for 4.5 h. The liver targeting efficiency of the Gd-labeled PLA-PEG nanoparticles in rats was 14.57 comparing with Magnevist injection. Therefore, the Gd-labeled nanoparticles showed the potential as targeting molecular MRI contrast agent for further clinical utilization.
The action of phenyl <i>iso</i>cyanate on insulin (1936)

HOPKINS & WORMALL [1934, 2] found that the action of phenyl isocyanate on insulin caused complete, or almost complete, loss of hypoglycaemic activity very rapidly at pH 8 and at 5-8'. Previous chemical and immunological in- vestigations on various phenylcarbamido-protein derivatives [Hopkins & Wormall, 1933, 1, 2; 1934, 1] indicate that phenyl isocyanate probably reacts with free amino-groups and causes no other very drastic change in the protein molecule. The conclusion was reached, therefore, that the free amino-groups of insulin, or at least some of them, are essential for its activity. Jensen et al. [1934] had simultaneously reached the same conclusion [cf. also Jensen & Evans, 1935].
Assessing and comparing influencing factors of residual stresses in selective laser melting using a novel analysis method (2012)

During selective laser melting, the irradiated material experiences large temperature fluctuations in a short time which causes unwanted thermal stresses. In order to assess thermal stresses in a simple and fast way, a new pragmatic method is developed, namely the bridge curvature method. The bridge curvature method is used to assess and qualitatively compare the influence of different laser scan patterns, laser parameter settings and more fundamental process changes on residual stresses. The results from the experiments, as well as the findings from literature, lead to two general conclusions: changes that reduce the high temperature gradient, like using short scan vectors and preheating of the base plate, reduce the thermal stresses. And, thermal stresses in a particular direction can be reduced by optimal choice of the orientation of scan vectors. The experiments indicate the reliability of the bridge curvature method. Statistical analysis is used to check the repeatability of the method and to quantify the uncertainties during measurement.
Complaining customers, service recovery and continuous improvement (1998)

Notes the fact that dissatisfied customers may not complain to the service provider, but will tell a number of people about the bad service they have received. Looks at factors related to the development of a service recovery system to ensure that dissatisfied customers are dealt with effectively so as to ensure they receive appropriate levels of service and to maximize customer retention. Considers factors such as the reasons for customer complaints, reciprocity and complaint handling and ways to instil a service recovery strategy.
Events in Apoptosis (1996)

Cytoplasmic acidification is now recognized as a feature of apoptosis in a variety of systems. However, its relation to other events in the process of apoptosis is not yet characterized. In this work, we examined the effect of BCL-2 overexpression on acidification mediated by cycloheximide treatment or Fas ligation in Jurkat T-lymphoblasts. We find that BCL-2 overexpression attenuates cytoplasmic acidification and apoptosis detected by annexin V labeling. Acidification and phosphatidylserine externalization were found to occur concurrently. We also examined the requirement for protease activation for cytoplasmic acidification to occur and found that inhibition of interleukin-1beta converting enzyme/CED-3 family proteases (using carbobenzoxy-Val-Ala-Asp-fluoromethylketone, an inhibitor of these proteases) prevents acidification and apoptosis mediated by Fas ligation. These studies suggest that BCL-2 acts at a point upstream of acidification and that protease activation is also upstream of acidification.
Efficient Soft-Input Soft-Output MIMO Detection via Improved M-Algorithm (2010)

In this paper, we propose a new soft-input soft-output (SISO) multi-input multi-output (MIMO) detection technique, called an improved SISO M-algorithm (ISS-MA). We modify the conventional M-algorithm to improve the performance-complexity trade-off of the SISO symbol detector. Towards this end, an improved path metric is proposed, which accounts for the information on undecided symbols at a particular path visited. The inclusion of this information is enabled through a bias term which is added to the conventional path metric in order to reflect the contributions of the undecided symbols. We derive the bias term using soft unconstrained linear estimates of undecided symbols. As a result, the ISS-MA that picks up the best M candidates based on this modified path metric exhibits improved performance/complexity trade-off compared to the existing SISO detectors. According to extensive simulations performed over i.i.d. Rayleigh fading channels, the proposed SISO detector yields significantly lower complexity than other symbol detectors while maintaining strong performance especially in high dimensional systems.
Rapid Inactivation of Rotaviruses by Exposure to Acid Buffer or Acidic Gastric Juice (1985)

Inactivation rates of three bovine and several primate-origin rotaviruses were determined during exposure to acid buffers at pH 2.0, pH 3.0 or pH 4.0. Each rotavirus was inactivated at pH 2.0 (the acidity most resembling the normal fasting stomach) very rapidly, with half-lives for infectivity determined to be 1 min or less. Each rotavirus was inactivated at a much slower rate at pH 3.0; inactivation at pH 4.0 was minimal. No remarkable differences in acid resistance between different rotavirus strains were detected. Although these determinations were performed at room temperature (23 degrees C), experiments at diverse temperatures indicated an even more rapid rate of viral inactivation by acid at normal body temperature (37 degrees C). Studies of rotavirus exposed to natural human gastric juice at pH 1.8 or pH 2.1 revealed a rate of virus inactivation similar to that observed with glycine buffer of identical pH.
Nanopore Structure Buildup during Endodontic Cement Hydration Studied by Time-Domain Nuclear Magnetic Resonance of Lower and Higher Mobility <sup>1</sup>H (2010)

Time-domain nuclear magnetic resonance (TD-NMR) of 1H nuclei has been used to monitor and model changes of endodontic cement pastes during hydration, from the initial reaction period up to hours and days. The 1H in the samples are divided into two major spin groups by fitting each free induction decay, acquired after the second pulse of an inversion recovery (I-R) pulse sequence with variable interpulse delay, by the sum of a quasi-Gaussian (signal from low mobility nuclei) and an exponential (from higher mobility nuclei). The extrapolations to zero time of the signals from the two spin groups give two sets of I-R data that have been analyzed to give quasi-continuous T1 distributions. After about a day, two clearly solid components appear. From a day to a few days, three liquid populations are identified, one of them mainly in the low-mobility spin group, which later merge, giving a single T1 or T2 peak. The rapid onset of the solid components, at the cost of the liquid, and the rapid changes of the relaxation time distributions of all components are clear indicators of the amount and kinetics of reaction products formation (C-S-H gel and Portlandite) and of the C-S-H micronanoporous structure buildup and evolution. At 30 days of hydration, the very short T1 and T2 liquid component (T1 ≅ 200 μs and T2 ≅ 50 μs) can be assigned to C-S-H intralayer water (thickness of the order of fractions of a nanometer) and the remaining liquid signal to interlayer water (thickness of the order of 1 nm). Comparisons are made among a widely used commercial endodontic cement paste and two more recent commercial pastes, with additive compounds to make the hydration process faster and to increase the workability. Parameters can be extracted from the data to characterize the different kinetics and nanostructure of the pore space formed up to 30 days. The parameters are in agreement with the expected effects of the additives, so the parameters can be used to optimize the formulation of new pastes, in order to improve their therapeutic performance.
A survey of techniques for formal verification of combinational circuits (1997)

With the increase in the complexity of present day systems, proving the correctness of a design has become a major concern. Simulation based methodologies are generally inadequate to validate the correctness of a design with a reasonable confidence. More and more designers are moving towards formal methods to guarantee the correctness of their designs. The authors survey some state-of-the-art techniques used to perform automatic verification of combinational circuits. They classify the current approaches for combinational verification into two categories: functional and structural. The functional methods consist of representing a circuit as a canonical decision diagram. Two circuits are equivalent if and only if their decision diagrams are equal. The structural methods consist of identifying related nodes in the circuit and using them to simplify the problem of verification. They briefly describe some of the methods in both the categories and discuss their merits and drawbacks.
Embedded Soft-Core Processor-Based Built-In Self-Test of Field Programmable Gate Arrays (2010)

ii Acknowledgments iv List of Tables ix List of Figures xi List of Abbreviations xv Chapter One. Introduction 1 1.1 Overview of Built-In Self-Test 2 1.2 Introduction to Field Programmable Gate Arrays (FPGAs) 4 1.3 Overview of Virtex-5 FPGAs 7 1.4 BIST for FPGAs 10 1.5 Single Event Upsets in FPGAs 11 1.6 Verification by Fault Injection 13 1.7 Thesis Statement 14 1.8 Thesis Format 15 1.9 References 15 Chapter Two. Built-In Self-Test of Configurable Logic Blocks in Virtex-5 FPGAs 18 2.
The Ordinal Serial Encoding Model: Serial Memory in Spiking Neurons (2010)

In a world dominated by temporal order, memory capable of processing, encoding and subsequently recalling ordered information is very important. Over the decades this memory, known as serial memory, has been extensively studied, and its effects are well known. Many models have also been developed, and while these models are able to reproduce the behavioural effects observed in human recall studies, they are not always implementable in a biologically plausible manner. This thesis presents the Ordinal Serial Encoding model, a model inspired by biology and designed with a broader view of general cognitive architectures in mind. This model has the advantage of simplicity, and we show how neuro-plausibility can be achieved by employing the principles of the Neural Engineering Framework in the model’s design. Additionally, we demonstrate that not only is the model able to closely mirror human performance in various recall tasks, but the behaviour of the model is itself a consequence of the underlying neural architecture.
Performance Enhancement of OAM-MIMO Using Successive Interference Cancellation (2019)

This paper proposes a method that employs successive interference cancellation (SIC) to further enhance the capacity of uniform circular array (UCA)-based orbital angular momentum (OAM)- MIMO systems. The central feature of the proposed approach is to exploit the additional space diversity benefit in the remaining streams by means of SIC owing to the large difference in the received power among different UCAs in each OAM mode. Therefore, it is expected that the proposed method can further stabilize the performance of UCA-based OAM-MIMO along with the communication distance. Our numerical results show that the proposed method outperforms the traditional method without SIC in terms of the system capacity owing to the large received power difference among different UCAs.
Detection of Actinobacillus pleuropneumoniae Infection in Pigs. (1987)

It is difficult to control the spread of porcine haemophilus pleuropneumonia caused by Actinobacillus pleuropneumoniae because there is no sensitive and specific way to accurately determine whether or not a pig herd is infected. This paper reports bacteriological and serological techniques used to detect A. pleuropneumoniae infection in pigs from a herd with endemic disease.The bacteria were isolated from the anterior nasal mucosa of grower pigs, but not from younger or older pigs. Bacteriological culture of several tissues from the respiratory tract showed that nine of ten young finishing pigs were infected, but culture of lung tissue from slaughtered hogs detected infection in only 39 of 288 (13.5%). Both cooler storage temperature and use of selective medium prolonged the time that lung tissue could be stored and the organism still recovered. An enzyme-linked immunosorbent assay detected serotype-specific antibodies in serum of infected pigs.
Mesh computer algorithms for computational geometry (1989)

Asymptotically optimal parallel algorithms are presented for use on a mesh computer to determine several fundamental geometric properties of figures. For example, given multiple figures represented by the Cartesian coordinates of n or fewer planar vertices, distributed one point per processor on a two-dimensional mesh computer with n simple processing elements, Theta (n/sup 1/2/>or=-time algorithms are given for identifying the convex hull and smallest enclosing box of each figure. Given two such figures, a Theta (n/sup 1/2/>or=-time algorithm is given to decide if the two figures are linearly separable. Given n or fewer planar points, Theta (n/sup 1/2/>or=-time algorithms are given to solve the all-nearest neighbor problems for points and for sets of points. Given n or fewer circles, convex figures, hyperplanes, simple polygons, orthogonal polygons, or iso-oriented rectangles, Theta (n/sup 1/2/>or=-time algorithms are given to solve a variety of area and intersection problems. Since any serial computer has worst-case time of Omega (n) when processing n points, these algorithms show that the mesh computer provides significantly better solutions to these problems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Ketone body production and disposal: Effects of fasting, diabetes, and exercise (1989)

Turnover studies performed during progressive fasting in normal subjects indicate that the production rate and the concentration of KB rise markedly during the early phase of fasting and start reaching a plateau after about 5 days. In addition to increased production, a reduction in the metabolic clearance rate of KB contributes to the hyperketonemia. This reduced metabolic clearance rate reflects essentially the progressive saturation of muscular ketone uptake that occurs with increasing ketonemia. The hormonal and metabolic environment of fasting plays only a minor role in this process, since a fall in KB metabolic clearance similar to that observed during fasting is observed if hyperketonemia is artificially induced in the postabsorptive state by the infusion of exogenous ketones. As extraction of KB by muscle becomes limited during ongoing fasting, KB are preferentially taken up by the brain to serve as a substrate replacing glucose. The remarkable stability of ketonemia during prolonged fasting is maintained through the operation of a negative feedback mechanism whereby KB tend to restrain their own production rate. The antilipolytic and insulinotropic effects of KB are instrumental in this process. This homeostatic mechanism maintains ketogenesis only slightly above the maximal metabolic disposal rate, the difference corresponding to urinary excretion, which is always below 10% of total turnover under physiologic conditions. When type I insulin-deprived diabetic patients are compared at the same KB concentration with control subjects with fasting ketosis, the characteristics of KB kinetics are comparable in the two groups. The maximal KB removal capacity is identical in the two situations, and it is not possible to identify a ketone removal defect specific to diabetes. Thus, these data favor the concept that excessive production of KB represent the main factor leading to uncontrolled hyperketonemia. It should be realized that a production exceeding only slightly that prevailing during prolonged fasting is sufficient to cause a progressive build-up in concentration, leading to uncontrolled diabetic ketosis. In the overnight-fasted state, a prolonged exercise (2 h) performed at moderate intensity (50% VO2 max) stimulates the capacity of muscle to extract ketones from blood as evidenced by a stimulation of the metabolic clearance rate.(ABSTRACT TRUNCATED AT 400 WORDS)
Human Infections Caused by Lactobacilli (1947)

Journal Article Human Infections Caused by Lactobacilli Get access E. Biocca, E. Biocca From the Laboratório Paulista de Biologia, São Paulo, Brazil Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Seppilli A. Seppilli From the Laboratório Paulista de Biologia, São Paulo, Brazil Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 81, Issue 2, September 1947, Pages 112–115, https://doi.org/10.1093/infdis/81.2.112 Published: 01 September 1947 Article history Received: 31 October 1946 Published: 01 September 1947