gebhart/patrepeval huggingface dataset:
Sp1 and Sp3 foci distribution throughout mitosis (2006)

The mammalian transcription factors Sp1 and Sp3 compete for the same DNA binding sites but play different roles in the regulation of expression of numerous genes. It is known that, in the interphase nucleus, Sp1 and Sp3 are organized into distinct foci. In this study, we show that throughout the mitotic process, while being displaced from the condensed chromosomes and dispersed throughout the cell, Sp1 and Sp3 maintain their separate punctate distributions. In metaphase, both Sp1 and Sp3 foci show a high degree of colocalization with microfilaments, suggesting that F-actin is involved in the organization of Sp1 and Sp3 foci during mitosis. Constant Sp1 and Sp3 levels were observed during mitosis, signifying a recovery of the pre-existing Sp1 and Sp3 population in newly formed nuclei. In late telophase, Sp1 and Sp3 are equally segregated between daughter cells, and their subnuclear organization as distinct foci is restored in a sequential fashion with Sp3 regrouping into the newly formed nuclei prior to Sp1. Both Sp1 and Sp3 return to the nuclei ahead of RNA polymerase II. Our results support a model in which entry of Sp1, Sp3 and RNA polymerase II into the newly formed nuclei is an ordered process.
Picture-processing techniques for geometrical tolerance checking of integrated-circuit layouts (1980)

The checking of geometrical constraints on integrated-circuit layouts is notoriously slow and costly when carried out purely by software. This paper introduces a new approach, in which layers are converted into digitised pictorial form and processed by simple hardware operating like a computer peripheral. This hardware reports to the computer all cases where constraints may be violated, and these cases are investigated in detail purely by software. The advantage of this approach is the reduction in the total amount of c.p.u. time required for constraint checking.
Enhancement of Tumor Immunotherapy by Blockade of a Prostate Tumor Derived Immunosuppressive Factor (2006)

Abstract : Slit2 is a soluble protein that has been demonstrated to regulate cell migration and inhibit inflammatory reactions. Recent studies suggest that Slit2 may play a role in tumor development. However conflict results have been reported about the expression level of Slit2 in normal and tumor tissues and the effect of Slit2 on development. The current studies in this report have for the first time demonstrated that forced expression of Slit2 in tumors suppresses the growth of human prostate tumor Du145 fibrosarcoma HT1080 and epidermoid tumor A431 cells in an anchorage independent way. Further experiments indicate that Slit2 inhibits tumor growth and reduces metastasis of HT1080 tumors in lungs of nude mice. Additionally in situ detection of transcriptional level indicates that Slit2 is down regulated in human tumor samples compared to normal tissues that mostly express Slit2 mRNA. Since all three tumor cell lines in the current studies express Robo4 a receptor for Slit2, the suppressive effect of Slit2 on tumors is likely mediated by the interaction of Slit2 with the receptor. These data imply that Slit2 is a tumor suppressor which is down regulated during tumor development. The effect of Slit2 on tumorigenesis is largely unexplored and further studies are required to define the mechanism for Slit2 mediated suppression of tumors.
Challenges in lung transplantation (2011)

Lung transplantation is an established therapy for end-stage pulmonary disorders in selected patients without significant comorbidities. The particular constraints associated with organ transplantation from deceased donors involve specific allocation rules in order to optimise the medical efficacy of the procedure. Comparison of different policies adopted by national transplant agencies reveals that an optimal and unique allocation system is an elusive goal, and that practical, geographical and logistic parameters must be taken into account. A solution to attenuate the imbalance between the number of lung transplant candidates and the limited availability of organs is to consider marginal donors. In particular, assessment and restoration of gas exchange capacity ex vivo in explanted lungs is a new and promising approach that some lung transplant programmes have started to apply in clinical practice. Chronic lung allograft dysfunction, and especially bronchiolitis obliterans, remains the major medium- and long-term problem in lung transplantation with a major impact on survival. Although there is to date no cure for established bronchiolitis obliterans, new preventive strategies have the potential to limit the burden of this feared complication. Unfortunately, randomised prospective studies are infrequent in the field of lung transplantation, and data obtained from larger studies involving kidney or liver recipients are not always relevant for this purpose.
A prototype of video see-through mixed reality interactive system (2004)

Mixed reality (MR), sometimes called enhanced reality, is a variety of virtual environment (VE) which explores various approaches to combine natural environment with immersive display technology. VE technologies completely immerse a user inside a synthetic environment. In contrast, MR system adds electronic data from a cyberspace on the physical space as a base, allows the users to see the real world with virtual objects superimposed upon. Moreover, MR can assist the users interact with the virtual object in the more realistic environment. The objective of our research is to investigate the potential of MR technique on improving interaction between human and computer through developing a video-see through mixed reality system. Further applications would be built upon this generic platform.
Phenotype and function of CD4+ T cells in mice lacking invariant chain (1996)

Mice bearing a targeted disruption of the gene encoding the invariant chain (Ii) have provided a deeper understanding of the critical role that Ii plays in the assembly, transport, and peptide occupancy of MHC class II molecules. In this study, we have investigated the consequence of the altered class II expression in Ii-deficient (Ii zero) mice on the phenotype and function of their CD4+ T cells. As seen by others, these mice show a sharp reduction in the CD4+8- subset in the thymus and periphery. Furthermore, a large proportion of the peripheral CD4+, but not CD8+, T cells in Ii zero mice exhibit decreased surface TCR-alpha beta levels and express markers of T cell activation. Although the CD4+ T cells respond to mitogens, anti-CD3 mAbs, and alloantigens, they respond poorly to the bacterial superantigen staphylococcal enterotoxin B and do not respond to peptide and protein Ags. Analysis of reciprocal radiation bone marrow chimeras constructed using Ii zero and wild-type mice indicate that the lack of Ii in the thymus is responsible for the phenotype of the CD4+ T cells in mutant mice. These results suggest that the altered thymic peptide repertoire displayed by class II molecules in the absence of Ii has a dramatic impact on the selection of CD4+ T cells and their phenotype in the periphery.
Analytical Inverse Kinematics for 7 DOF Redundant Manipulators with Joint Limits (2007)

This paper addresses the inverse kinematic problem for 7 DOF anthropomorphic manipulators with joint limits. Specifically, the paper analyzes how the joint limits restrict the redundancy to develop practical inverse kinematic resolutions under the joint limits. First, the manipulator model considered in this paper is provided. Second, how to solve the inverse kinematics of the redundant manipulator is described. Third, how joint limits affect the inverse kinematic solutions is investigated. Forth, several suggestions for resolving redundancy under the joint limits are presented. Lastly, the effectiveness of the redundancy resolutions is illustrated by simulation results.
“The city” (1875)

“The city” Get access William George Black William George Black Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s5-IV, Issue 92, 2 October 1875, Page 275, https://doi.org/10.1093/nq/s5-IV.92.275g Published: 02 October 1875
Magnetic and Structural Properties of Metastable Fe-Cu Solid Solutions (1964)

Metastable Fe-Cu solid solutions with Cu concentrations up to 80% were obtained by simultaneous vapor deposition of Fe and Cu on cold substrates. Alloys with less than 50% Cu are bcc and ferromagnetic, the average magnetic moment per atom being slightly higher than for simple dilution. The Curie temperature decreases and the spectroscopic g factor increases with Cu concentration. Alloys with more than 70% Cu are fcc and appear to be paramagnetic. At elevated temperatures the alloys decompose into a bcc Ferich and an fcc Cu-rich phase. The kinetics of precipitation were studied by means of coercivity measurements; from these an activation energy Q=29 kcal/mole was determined.
La decadencia de un mito (2004)

Es obvio que cualquier medio de comunicación está limitado. Lo está en cuanto a forma, estilo, contenido. Lo está en tanto que todos y todo aquello que lo conforma se encuentra coactado igualmente por nuestra mera presencia, en mayor o menor medida. No todos tenemos la misma capacidad para expresarnos dignamente.Deep Blue no podrá con GaryTampoco las máquinas se salvan de la quema. Lo quieran o no todos aquellos defensores del futuro informático, aquellos que apuestan por la derrota de Kasparov frente a una computadora han de atender que detrás de tamaño invento hay hombres. El ajedrecista no perderá frente a la máquina jamás, lo hará, más bien, ante los cientos de personas encargadas del diseño de esta.
Enhanced formation of >C1 Products in Electroreduction of CO<sub>2</sub> by Adding a CO<sub>2</sub> Adsorption Component to a Gas‐Diffusion Layer‐Type Catalytic Electrode (2017)

The addition of a CO<sub>2</sub> -adsorption component (substituted imidazolate-based SIM-1 crystals) to a gas-diffusion layer-type catalytic electrode enhances the activity and especially the selectivity towards >C1 carbon chain products (ethanol, acetone, and isopropanol) of a Pt-based electrocatalyst that is not able to form products of CO<sub>2</sub> reduction involving C-C bond formation under conventional (liquid-phase) conditions. This indicates that the increase of the effective CO<sub>2</sub> concentration at the electrode active surface is the factor controlling the formation of >C1 products rather than only the intrinsic properties of the electrocatalyst.
Arginine Deficiency Causes Runting in the Suckling Period by Selectively Activating the Stress Kinase GCN2 (2011)

Suckling "F/A2" mice, which overexpress arginase-I in their enterocytes, develop a syndrome (hypoargininemia, reduced hair and muscle growth, impaired B-cell maturation) that resembles IGF1 deficiency. The syndrome may result from an impaired function of the GH-IGF1 axis, activation of the stress-kinase GCN2, and/or blocking of the mTORC1-signaling pathway. Arginine deficiency inhibited GH secretion and decreased liver Igf1 mRNA and plasma IGF1 concentration, but did not change muscle IGF1 concentration. GH supplementation induced Igf1 mRNA synthesis, but did not restore growth, ruling out direct involvement of the GH-IGF1 axis. In C2C12 muscle cells, arginine withdrawal activated GCN2 signaling, without impacting mTORC1 signaling. In F/A2 mice, the reduction of plasma and tissue arginine concentrations to ∼25% of wild-type values activated GCN2 signaling, but mTORC1-mediated signaling remained unaffected. Gcn2-deficient F/A2 mice suffered from hypoglycemia and died shortly after birth. Because common targets of all stress kinases (eIF2α phosphorylation, Chop mRNA expression) were not increased in these mice, the effects of arginine deficiency were solely mediated by GCN2.
10.3 A 12nm CMOS RF Transceiver Supporting 4G/5G UL MIMO (2020)

With the explosion of online streaming, artificial intelligence and mobile computing, higher wireless data-rates are required, which in 5G NR are achieved by adopting massive MIMO and Carrier Aggregation (CA) with a wide channel bandwidth (BW) up to 200MHz. Together with the requirement for LTE+NR Dual Connectivity (EN-DC), the transceiver (XCVR) and RF front-end complexity increases dramatically requiring new techniques to maintain a small and cost-effective RF implementation. In this work, a 12nm CMOS 2/3/4/5G multi-RAT (Radio Access Technology) XCVR is presented, capable of supporting up to 6 inter-band CA DL with flexible 4×4 MIMO port selection and 2 inter-band CA UL with coherent 2×2 MIMO. In NR 200MHz 4×4 MIMO 256-QAM mode a throughput up to 5Gb/s can be achieved.
Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease. (1992)

The consistency of these findings across populations, along with the demonstration of reasonable biological pathways for this effect of alcohol, provides strong support for the hypothesis that light-to-moderate alcohol intake is protective against heart disease in men.
Q-Switched Laser Goniopuncture (1974)

A new approach to treatment of glaucoma has been tried, in which Q-switched laser bursts are delivered to the anterior chamber angle. Nonthermal effects emerge as an important factor in the biological action of such laser impulses. Laser-induced defects in the filtering zone produced by Q-switched impulses have been traced histologically. Fifty patients (all of them awaiting glaucoma surgery) were treated by the method described above. The maximum follow-up study was three years. The average drop in the intraocular tension was 8.3 mm Hg. Improvement in the outflow facility was also characteristic. No appreciable adverse effects have been traced. The controlled state of the intraocular pressure was maintained by repeated laser goniopuncture sessions on the eyes of 46 patients (in four cases the tension was not controlled). Q-switched laser goniopuncture seems to offer a new aspect in the treatment of glaucoma, but further extensive studies and several years of follow-up study are certainly needed.
The integration of BNP and NT-proBNP into clinical medicine (2007)

B-type natriuretic peptide (BNP) and NTproBNP have been shown to be extremely helpful in the diagnosis and management of patients with heart failure (HF). These neurohormones are predominately secreted from the left and the right cardiac ventricle in response to volume and pressure overload. BNP and NT-proBNP can be seen as quantitative markers of HF summarizing the extent of systolic and diastolic left ventricular dysfunction. Research data from clinical studies and six years of clinical experience with BNP allow us to provide clear recommendations regarding the integration of BNP/NT-proBNP into clinical medicine. With multiple additional indications in prospect, current evidence clearly supports the use of BNP and NT-proBNP in three clinical settings: patients with acute dyspnoea, prior to discharge in patients hospitalised with acute HF, and the longterm management of patients with HF.
The implications of online investing (2000)

article Free Access Share on The implications of online investing Authors: Prabhudev Konana Department of Management Science and Information Systems in the Graduate School of Business at The University of Texas at Austin Department of Management Science and Information Systems in the Graduate School of Business at The University of Texas at AustinView Profile , Nirup M. Menon Department of Information Systems Quantitative Sciences in the College of Business Administration at Texas Tech University in Lubbock, Texas Department of Information Systems Quantitative Sciences in the College of Business Administration at Texas Tech University in Lubbock, TexasView Profile , Sridhar Balasubramanian Department of Marketing in the Graduate School of Business at The University of Texas at Austin Department of Marketing in the Graduate School of Business at The University of Texas at AustinView Profile Authors Info & Claims Communications of the ACMVolume 43Issue 1Jan. 2000 pp 34–41https://doi.org/10.1145/323830.323842Online:01 January 2000Publication History 45citation1,885DownloadsMetricsTotal Citations45Total Downloads1,885Last 12 Months140Last 6 weeks15 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Learning probabilistic models of link structure (2003)

Most real-world data is heterogeneous and richly interconnected. Examples include the Web, hypertext, bibliometric data and social networks. In contrast, most statistical learning methods work with &quot;flat&quot; data representations, forcing us to convert our data into a form that loses much of the link structure. The recently introduced framework of probabilistic relational models (PRMs) embraces the object-relational nature of structured data by capturing probabilistic interactions between attributes of related entities. In this paper, we extend this framework by modeling interactions between the attributes and the link structure itself. An advantage of our approach is a unified generarive model for both content and relational structure. We propose two mechanisms for representing a probabilistic distribution over link structures: reference uncertainty and existence uncertainty. We describe the appropriate conditions for using each model and present learning algorithms for each. We present experimental results showing that the learned models can be used to predict link structure and, moreover, the observed link structure can be used to provide better predictions for the attributes in the model.
Gestational diabetes: The forerunner for the development of maternal and childhood obesity and metabolic syndrome? (2008)

The current prevalence of obesity in both adults and children and associated disorders of blood pressure and lipid metabolism, suggest a perpetuating cycle of increasing obesity, insulin resistance, and abnormal lipid metabolism, which has ominous consequences for future generations.
Fast collective operations using shared and remote memory access protocols on clusters (2004)

This paper describes a novel methodology for implementing a common set of collective communication operations on clusters based on symmetric multiprocessor (SMP) nodes. Called Shared-Remote-Memory collectives, or SRM, our approach replaces the point-to-point message passing, traditionally used in implementation of collective message-passing operations, with a combination of shared and remote memory access (RMA) protocols that are used to implement semantics of the collective operations directly. Appropriate embedding of the communication graphs in a cluster maximizes the use of shared memory and reduces network communication. Substantial performance improvements are achieved over the highly optimized commercial IBM implementation and the open-source MPICH implementation of MPI across a wide range of message sizes on the IBM SP. For example, depending on the message size and number of processors, SRM implementation of broadcast, reduce, and barrier outperforms IBM MPI/spl I.bar/Bcast by 27-84%, MPI/spl I.bar/Reduce by 24-79%, and MPI/spl I.bar/Barrier by 73% on 256 processors, respectively.
Principles of Mode‐Locking (2008)

This chapter contains sections titled: Processes Involved in Mode-Locking Active Mode-Locking Passive Mode-Locking Using Saturable Absorbers Solid-State Laser Mode-Locking Using the Optical Kerr Effect Problems
The robust design approach for reducing cogging torque in permanent magnet motors [for CD-ROM spindles] (1998)

This paper discusses the robust design method for reducing the cogging torque developed in permanent magnet motors and improving the N/S ratio (noise to signal ratio) between the cogging torque and average operational torque. The robust design method used is Taguchi's approach which is applied the first time to determine the optimum design parameters of a brushless DC spindle motor used in data storage systems. The results show that the robust design method is a very efficient and effective approach in designing disk drive spindle motors for high performance.
Massively parallel structured multifrontal solver for time-harmonic elastic waves in 3-D anisotropic media (2012)

We present a massively parallel structured multifrontal solver for the equations describing time-harmonic elastic waves in 3-D anisotropic media. We use a multicomponent second-order finite-difference method. We extend the corresponding stencil to enhance the accuracy of the discretization without increasing the order. This accuracy is aligned with the tolerance level used for the Hierarchically SemiSeparable (HSS) low rank matrix compression underlying our solver. The interplay between the finite accuracy discretization and the finite accuracy matrix solver yields the key strategy which leads to the architecture of our algorithm. We analyse the relevant matrix structures, (numerically) estimate the rank of the dense matrices prior to the HSS compression and study the effect of anisotropy, and deduce the complexity and storage requirements of our algorithm.
SALAMI (<i>S</i>pectrum <i>AL</i>ignments Using High <i>A</i>ccuracy <i>M</i>ass and H<i>I</i>gh Sensitivity Data): How To Make the Best out of Hybrid MS/MS Data (2008)

We present a software algorithm that combines ion trap and orbitrap product ion spectra acquired in parallel. The hybrid product ion spectra identify more peptides than when using two separate searches for the orbitrap and LTQ data. The program extracts the high-accuracy mass data from the Orbitrap mass analyzer and combines it with the high-sensitivity data analyzed in the LTQ linear ion trap; the m/z values of the high-confidence fragment ions are corrected to orbitrap mass accuracies and the fragment ion intensities are amplified. This approach utilizes the parallel spectrum measurement capabilities of the LTQ-Orbitrap. We present our approach to handling this type of hybrid data, explain our alignment program, and discuss the advantages of the chosen methodology.