gebhart/patrepeval huggingface dataset:
Matricellular proteins in the heart: possible role during stress and remodeling (2004)

Matricellular proteins are extracellular matrix proteins that modulate cell-matrix interactions and cell function, and do not seem to have a direct structural role. The family includes tenascin-C (TN-C), tenascin-X (TN-X), osteonectin, osteopontin, thrombospondin-1 (TSP1) and thrombospondin-2 (TSP2). Expression of matricellular proteins is high during embryogenesis, but almost absent during normal postnatal life. Interestingly, it re-appears in response to injury. Left ventricular remodeling is a complicated process that occurs in the stressed heart, and is still not completely understood. Several members of the matricellular protein family, like tenascin-C, osteopontin, and osteonectin are up-regulated after cardiac injury. Therefore, this group of proteins may have crucial functions in the heart coping with stress. This review will focus on the expression, regulation and function of these matricellular proteins, and will discuss the crucial functions that these proteins might exert during remodeling of the stressed heart.
Benzazepinones. Synthesis of the monoaza analog of diazepam, and the correct structure of the benzoylpropionanilide cyclization product (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBenzazepinones. Synthesis of the monoaza analog of diazepam, and the correct structure of the benzoylpropionanilide cyclization productBernard Loev, Richard B. Greenwald, Marjorie M. Goodman, and Charles L. ZirkleCite this: J. Med. Chem. 1971, 14, 9, 849–852Publication Date (Print):September 1, 1971Publication History Published online1 May 2002Published inissue 1 September 1971https://pubs.acs.org/doi/10.1021/jm00291a018https://doi.org/10.1021/jm00291a018research-articleACS PublicationsRequest reuse permissionsArticle Views247Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Density Control of Poly(ethylene glycol) Layer To Regulate Cellular Attachment (2007)

A wide variety of cells usually integrate and respond to the microscale environment, such as soluble protein factors, extracellular matrix proteins, and contacts with neighboring cells. To gain insight into cellular microenvironment design, we investigated two-dimensional microarray formation of endothelial cells on a micropatterned poly(ethylene glycol) (PEG)-brushed surface, based on the relationship between PEG chain density and cellular attachment. The patterned substrates consisted of two regions: the PEG surface that acts as a cell-resistant layer and the exposed substrate surface that promotes protein or cell adsorption. A PEG-brushed layer was constructed on a gold substrate using PEG with a mercapto group at the end of the chain. The density of the PEG-brushed layer increased substantially with repetitive adsorption/rinse cycles of PEG on the gold substrate, allowing marked reduction of nonspecific protein adsorption. These repeated adsorption/rinse cycles were further regulated by using longer (5 kDa) and shorter (2 kDa) PEG to construct PEG layers with different chain density, and subsequent micropatterning was achieved by plasma etching through a micropatterned metal mask. The effects of PEG chain density on pattern formation of cell attachment were determined on micropatterning of endothelial cells. The results indicated that cell pattern formation was strongly dependent on the PEG chain density and on the extent of protein adsorption. Notably, a PEG chain density high enough to inhibit outgrowth of endothelial cells from the cell-adhering region in the horizontal direction could be obtained only by employing formation of a short filler layer of PEG in the preconstructed longer PEG-brushed layer, which prevented nonspecific protein adsorption almost completely. In this way, a completely micropatterned array of endothelial cells with long-term viability was obtained. This clearly indicated the importance of a short underbrushed PEG layer in minimizing nonspecific protein adsorption for long-term maintenance of the active cell pattern. The strategy for cell patterning presented here can be employed in tissue engineering to study cell-cell and cell-surface interactions. It is also applicable for high-throughput screening and clinical diagnostics, as well as interfacing cellular and microfabricated components of biomedical microsystems.
Constructing stable grasps in 3D (2005)

This paper presents fast and simple algorithms for directly constructing stable grasps in 3D. The synthesis of stable grasps constructs virtual springs at the contacts, such that the grasped object is stable, and has a desired stiffness matrix about its stable equilibrium. The paper develops a simple geometric relation between the stiffness of the grasp and the spatial configuration of the virtual springs at the contacts. The stiffness of the grasp also depends on whether the points of contact stick, or slide without friction on the edges of the object.
Polycrystalline silicon on glass by aluminum-induced crystallization (2003)

We prepared thin polycrystalline silicon (poly-Si) films on glass by an aluminum-induced layer exchange (ALILE) process which is based on the aluminum-induced crystallization (AlC) of amorphous silicon (a-Si). During the ALILE process a glass/Al/a-Si stack is transformed into a glass/poly-Si/Al+Si structure. We investigated both the growth of the poly-Si layer and the final Al+Si layer on top of the poly-Si layer. Furthermore, we carried out the ALILE process on large glass substrates and on metal-coated glass substrates.
SODON: a high availability multi-source content distribution overlay (2005)

Multi-source content distribution and file download systems such as BitTorrent and Edonkey emerge as a better scheme than the traditional ftp systems in distributing files to very large scale systems. However, a major drawback of those systems is that they largely rely on a tracker server to maintain state information of a horde. Furthermore, if the peer holding all the pieces of a file leaves the system, there is a high probability that the other peers cannot download the entire file. We propose a scalable and highly available P2P multi-source content distribution system called SODON to solve those problems. SODON distributes all the pieces of a file from a seed to a number of carefully selected sub-seeds in order to guarantee a complete set of pieces that are available for a long time. The sub-seeds also work as sub-trackers to maintain the horde state information. As a result, the original tracker server is not overwhelmed by a large population of download requests. Our traces on BitTorrent and simulation result show that SODON is feasible to build, and the sub-seeding and sub-tracking schemes effectively reduce the tracker load while offering a comparatively high availability of shared files
Role of Lipooligosaccharide in Opa-Independent Invasion of <i>Neisseria gonorrhoeae</i> into Human Epithelial Cells (2000)

Lipooligosaccharide (LOS) has been implicated in the adhesion and invasion of host epithelial cells. We examined the adhesive and invasive abilities of isogenic gonococcal opacity-associated outer membrane protein-negative, pilus-positive (Opa-Pil+) Neisseria gonorrhoeae strains expressing genetically defined LOS. Strain F62 (Opa-Pil+), expressing the lacto-N-neotetraose and the galNac-lacto-N-neotetraose LOS, and its isogenic derivative that expressed only the lacto-N-neotetraose LOS (F62 Delta lgtD), adhered to, and invaded, to the same extent the human cervical epidermoid carcinoma cell line, ME180. While the adhesive abilities of Opa-Pil+ isogenic strains that express LOS molecules lacking the lacto-N-neotetraose structure were similar to that seen for F62, their invasive abilities were much lower than the strains expressing lacto-N-neotetraose. Fluorescence microscopy studies showed that the adherence of F62, but not the strains lacking lacto-N-neotetraose, induced the rearrangement of actin filaments under the adherent sites. Electron microscopy studies demonstrated that F62, but not the strains lacking lacto-N-neotetraose, formed extensive and intimate associations with epithelial cell membranes. Thus, in the absence of detectable Opa protein, the lacto-N-neotetraose LOS promotes gonococcal invasion into ME180 cells. The data also suggest that LOS is involved in the mobilization of actin filaments in host cells, and in the formation of a direct interaction between the bacterial outer membrane and the plasma membrane of ME180 cells.
Fabrication of Patterned Images in Photochromic Organic Microfibers (2010)

Photochromic spiropyran molecules were embedded in electrospun polymer microfibers. Electrospinning of a clear viscous chloroform solution containing a spiropyran and a matrix polymer, such as polystyrene and polyethylene oxide, affords polymer microfibers that are photoswitchable. Photomasked, 365 nm UV irradiation of the microfibers results in the generation of patterned color images owing to the selective transformation of the spiropyran molecules from their ring-closed SP to ring-opened MC form. The UV-irradiated areas display brilliant red fluorescence, which changes to green fluorescence upon prolonged irradiation.
Monolithic three-dimensional integration of carbon nanotube FET complementary logic circuits (2013)

In this paper, we experimentally demonstrate, for the first time, a scalable integration process for monolithic three-dimensional ICs (3D ICs) using carbon nanotube field-effect transistors (CNFETs). We demonstrate the flexibility of our approach using CNFETs with high I <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</inf> /I <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</inf> that can be placed on arbitrary layers of monolithic 3D ICs, and connected using conventional vias to build fully-complementary monolithic 3D logic gates and monolithic 3D multi-stage logic circuits. We also demonstrate that such monolithic 3D logic gates can operate correctly over a range of supply voltages from 3V to 0.2V.
Advances in Bone Marrow-Derived Cell Therapy: CD31-expressing Cells as Next Generation Cardiovascular Cell Therapy (2011)

In the past few years, bone marrow (BM)-derived cells have been used to regenerate damaged cardiovascular tissues post-myocardial infarction. Recent clinical trials have shown controversial results in recovering damaged cardiac tissue. New progress has shown that the underlying mechanisms of cell-based therapy relies more heavily on humoral and paracrine effects rather than on new tissue generation. However, studies have also reported the potential of new endothelial cell generation from BM cells. Thus, efforts have been made to identify cells having higher humoral or therapeutic effects as well as their surface markers. Specifically, BM-derived CD31+ cells were isolated by a surface marker and demonstrated high angio-vasculogenic effects. This article will describe recent advances in the therapeutic use of BM-derived cells and the usefulness of CD31+ cells.
Smartphone-Based Indoor Localization with Bluetooth Low Energy Beacons (2016)

Indoor wireless localization using Bluetooth Low Energy (BLE) beacons has attracted considerable attention after the release of the BLE protocol. In this paper, we propose an algorithm that uses the combination of channel-separate polynomial regression model (PRM), channel-separate fingerprinting (FP), outlier detection and extended Kalman filtering (EKF) for smartphone-based indoor localization with BLE beacons. The proposed algorithm uses FP and PRM to estimate the target's location and the distances between the target and BLE beacons respectively. We compare the performance of distance estimation that uses separate PRM for three advertisement channels (i.e., the separate strategy) with that use an aggregate PRM generated through the combination of information from all channels (i.e., the aggregate strategy). The performance of FP-based location estimation results of the separate strategy and the aggregate strategy are also compared. It was found that the separate strategy can provide higher accuracy; thus, it is preferred to adopt PRM and FP for each BLE advertisement channel separately. Furthermore, to enhance the robustness of the algorithm, a two-level outlier detection mechanism is designed. Distance and location estimates obtained from PRM and FP are passed to the first outlier detection to generate improved distance estimates for the EKF. After the EKF process, the second outlier detection algorithm based on statistical testing is further performed to remove the outliers. The proposed algorithm was evaluated by various field experiments. Results show that the proposed algorithm achieved the accuracy of <2.56 m at 90% of the time with dense deployment of BLE beacons (1 beacon per 9 m), which performs 35.82% better than <3.99 m from the Propagation Model (PM) + EKF algorithm and 15.77% more accurate than <3.04 m from the FP + EKF algorithm. With sparse deployment (1 beacon per 18 m), the proposed algorithm achieves the accuracies of <3.88 m at 90% of the time, which performs 49.58% more accurate than <8.00 m from the PM + EKF algorithm and 21.41% better than <4.94 m from the FP + EKF algorithm. Therefore, the proposed algorithm is especially useful to improve the localization accuracy in environments with sparse beacon deployment.
Development of fuel failure detection system for a high temperature gas cooled reactor. IV (1990)

For pt.III see ibid., vol.36, p.1261, (1989). A fuel failure detection (FFD) system using a wire-precipitator has been developed for a high-temperature gas-cooled reactor. For actual application of the FFD system, the response data to a precipitator for noble-gas fission products (FPs) released from coated particle fuels were measured under various in-core irradiating conditions. The dependency of precipitator counting rates on the fuel temperature and the reactor power was obtained by analyzing measured data. A model of the response function of a precipitator to the noble-gas FP nuclides was developed and its validity has been examined. By integrating these results, a state equation for the fuel failure detection can be determined. The response of a Ge gamma-ray spectrometer and a precipitator for a failed fuel sample was measured. The response curves of long-life nuclides are different from those of short-life nuclides. Using this difference, the fuel failure detection can be carried out.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A New Synthetic Method of (<i>Z</i>)‐4‐Aryl‐but‐2‐en‐1‐ols via Suzuki‐Miyaura Cross‐Coupling Reaction of 4‐Substituted 1,2‐Oxaborol‐2(5<i>H</i>)‐ols with Benzyl Bromides (2012)

Abstract Z and E configuration 4‐aryl‐but‐2‐en‐1‐ols were isolated from several terrestrial plants, and ( Z )‐4‐aryl‐but‐2en‐1‐ols were found to have choleretic activity. Strategies have been reported to synthesize ( E )‐4‐aryl‐but‐2‐en‐1ols with high selectivity. However, there is no method to obtain ( Z )‐4‐aryl‐but‐2‐en‐1‐ols with high selectivity now. We developed a Suzuki‐Miyaura cross‐coupling reaction of 1,2‐oxaborol‐2(5 H )‐ols with benzyl bromides to synthesize ( Z )‐4‐aryl‐but‐2‐en‐1‐ols, the products were obtained in up to 94% isolated yield.
On the generation and applications of the monopolar ("zeroth" like) mode in non circular patches (2004)

The paper shows that a mode similar to the TM/sub 01/ in circular geometries can be also excited in noncircular patches, short circuited in the center; the rectangular geometry has been chosen for it. Most of the interesting characteristics and excellent behaviour of the TM/sub 01/ short circuited ring, mainly useful for mobile user terminals, have been also found in the proposed geometry.
Raman spectroscopy of graphene and carbon nanotubes (2011)

This paper reviews progress that has been made in the use of Raman spectroscopy to study graphene and carbon nanotubes. These are two nanostructured forms of sp2 carbon materials that are of major current interest. These nanostructured materials have attracted particular attention because of their simplicity, small physical size and the exciting new science they have introduced. This review focuses on each of these materials systems individually and comparatively as prototype examples of nanostructured materials. In particular, this paper discusses the power of Raman spectroscopy as a probe and a characterization tool for sp2 carbon materials, with particular emphasis given to the field of photophysics. Some coverage is also given to the close relatives of these sp2 carbon materials, namely graphite, a three-dimensional (3D) material based on the AB stacking of individual graphene layers, and carbon nanoribbons, which are one-dimensional (1D) planar structures, where the width of the ribbon is on the nanometer length scale. Carbon nanoribbons differ from carbon nanotubes is that nanoribbons have edges, whereas nanotubes have terminations only at their two ends.
A potential photoaffinity probe for labelling the active site of aequorin: a photolabile coelenterazine analogue with a trifluoromethyldiazirine group (1995)

In order to clarify the active site of aequorin, we have successfully synthesized a photolabile analogue of coelenterazine with a trifluoromethyldiazirine group as a photoaffinity probe. Our studies on the chemi- and bio-luminescence of this novel analogue indicate that its behaviour is almost identical with that of natural coelenterazine in terms of luminescence characteristics. Therefore, the analogue with the photolabile diazirine should be a useful photoaffinity label for probing the detailed structure of aequorin.
Increased Plasma Levels of Thioredoxin in Patients with Glucose Intolerance (2005)

Glucose intolerance was associated with the high levels of thioredoxin. High levels of thioredoxin were related to the presence of CAD. The measurement of thioredoxin as the marker of oxidative stress may be useful for monitoring the development of the cardiovascular diseases.
Counteracting Activities of OCT4 and KLF4 during Reprogramming to Pluripotency (2014)

Differentiated cells can be reprogrammed into induced pluripotent stem cells (iPSCs) after overexpressing four transcription factors, of which Oct4 is essential. To elucidate the role of Oct4 during reprogramming, we investigated the immediate transcriptional response to inducible Oct4 overexpression in various somatic murine cell types using microarray analysis. By downregulating somatic-specific genes, Oct4 induction influenced each transcriptional program in a unique manner. A significant upregulation of pluripotent markers could not be detected. Therefore, OCT4 facilitates reprogramming by interfering with the somatic transcriptional network rather than by directly initiating a pluripotent gene-expression program. Finally, Oct4 overexpression upregulated the gene Mgarp in all the analyzed cell types. Strikingly, Mgarp expression decreases during the first steps of reprogramming due to a KLF4-dependent inhibition. At later stages, OCT4 counteracts the repressive activity of KLF4, thereby enhancing Mgarp expression. We show that this temporal expression pattern is crucial for the efficient generation of iPSCs.
Autophagy and inflammatory diseases (2013)

Autophagy is a cellular mechanism for the sequestration and degradation of intracellular pathogens and compromised organelles, particularly damaged mitochondria. Autophagy also clears other cellular components, such as inflammasomes and cytokines, thus providing an important means of regulating inflammation. Defects in autophagy have been found by genetic association studies to confer susceptibility to several autoimmune and inflammatory disorders, particularly inflammatory bowel disease. Thus, the manipulation of autophagy in disease situations is of growing interest for therapeutic targeting; however, the involvement of autophagy in cellular homoeostasis, in normal immune function and in inflammation is manifold. An appreciation of the intricacies of the contributions of this process to inflammation, and how these are altered by various immune and environmental stimuli, is essential for the understanding and interpretation of studies of inflammation and the design of therapeutics exploiting the manipulation of autophagy. This review focuses on the known roles of autophagy in the induction and maintenance of inflammation and on its role in the aetiology and regulation of inflammatory and autoimmune disorders.
Quantitative analysis aspects of the EEI correlation method (2013)

Extended Elastic Impedance (EEI) has proved to be a convenient framework for relating petrophysical properties from well logs directly to projections of prestack seismic reflectivity volumes. One common approach to this analysis involves sweeping through a range of projection angles, chi, and choosing the one that maximizes the correlation coefficient with a specified target log such as Gamma Ray or Water Saturation for lithology or fluid identification. Direct implementation of the correlation approach may result in statistical biases and loss of parity with reflection coefficients. A more robust analysis will be achieved if three recommendations are followed: 1.) Use the logarithm of EEI in the correlation analysis instead of full EEI, 2.) Perform the correlation analysis between the detrended target curve and detrended ln(EEI) curve, 3.) Use a band of high-correlation chi angles, or its center rather than the specific correlation maximum.
5‐HT<sub>4</sub> receptor antagonism in irritable bowel syndrome: effect of SB‐207266‐A on rectal sensitivity and small bowel transit (1999)

Our results support a role for the 5-HT4 receptor in the pathophysiology of irritable bowel syndrome and suggest that the selective 5-HT4 antagonist, SB-207266-A, is worthy of further evaluation in this disorder.
Generation of a packaging cell line for prolonged large‐scale production of high‐titer HIV‐1‐based lentiviral vector (2005)

These results demonstrate for the first time HIV-1-based lentiviral vector production on the large scale using a packaging cell line.