gebhart/patrepeval huggingface dataset:
The MISS speech synthesis system (2005)

To provide speech output for a major demonstration project of sophisticated computer based instruction, the Microprogrammed Intoned Speech Synthesizer (MISS) utilizing linear predictive coding techniques was developed. In addition to simple resynthesis of preanalyzed recorded speech, the MISS system can apply procedures to modify the pitch, duration and amplitude of individual words so that they can be concatenated into natural sounding utterances. Text analysis programs provide the linguistic parameters that direct MISS to apply the appropriate manipulations. We evaluate the quality of reproduction and storage requirements for this system in comparison with other systems.
Dynamic Relationship between IFN-γ and IL-2 Profile of <i>Mycobacterium tuberculosis</i> -Specific T Cells and Antigen Load (2007)

Distinct IFN-gamma and IL-2 profiles of Ag-specific CD4(+) T cells have recently been associated with different clinical disease states and Ag loads in viral infections. We assessed the kinetics and functional profile of Mycobacterium tuberculosis Ag-specific T cells secreting IFN-gamma and IL-2 in 23 patients with untreated active tuberculosis when bacterial and Ag loads are high and after curative treatment, when Ag load is reduced. The frequencies of M. tuberculosis Ag-specific IFN-gamma-secreting T cells declined during 28 mo of follow-up with an average percentage decline of 5.8% per year (p = 0.005), while the frequencies of Ag-specific IL-2-secreting T cells increased during treatment (p = 0.02). These contrasting dynamics for the two cytokines led to a progressive convergence of the frequencies of IFN-gamma- and IL-2-secreting cells over 28 mo. Simultaneous measurement of IFN-gamma and IL-2 secretion at the single-cell level revealed a codominance of IFN-gamma-only secreting and IFN-gamma/IL-2 dual secreting CD4(+) T cells in active disease that shifted to dominance of IFN-gamma/IL-2-secreting CD4(+) T cells and newly detectable IL-2-only secreting CD4(+) T cells during and after treatment. These distinct T cell functional signatures before and after treatment suggest a novel immunological marker of mycobacterial load and clinical status in tuberculosis that now requires validation in larger prospective studies.
Synthesis and micellization of amphiphilic poly(ethylene oxide)-block-poly(methylidene malonate 2.1.2.) diblock copolymers (2000)

Poly(ethylene oxide)-block-poly-(methylidene malonate 2.1.2.) diblock copolymers were prepared by anionic polymerization. They were characterized by SEC, 1H NMR spectroscopy and DSC. Their micellization behavior was examined in aqueous medium. The micelle size, as determined by dynamic light scattering, could be correlated to the degree of polymerization of each sequence in agreement with existing theories.
The Efficacy and Safety of the Hematoma Block for Fracture Reduction in Closed, Isolated Fractures (1997)

Fracture manipulation in the emergency department often requires some method of anesthesia. This study evaluates the efficacy and safety of the hematoma block in patients with closed, isolated fractures requiring manipulative reduction. Sixty-one patients treated with a hematoma block (HB group) prior to fracture manipulation were compared with 53 patients treated with either intravenous sedation or "conscious sedation" (NHB group). Using a pain analog scale, patients rated their pain from 1 (no pain) to 10 (severe pain) both prior to and during fracture manipulation. A pain differential score was calculated for each group. Results demonstrated pain differential scores of 2.7 and 0.8 for the HB and NHB groups, respectively. There were no complications associated with any of the procedures. Based on these results, we conclude that the hematoma block is an effective and safe method of providing anesthesia for fracture reduction in select patients.
Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice (2011)

Autosomal dominant hypophosphatemic rickets (ADHR) is unique among the disorders involving Fibroblast growth factor 23 (FGF23) because individuals with R176Q/W and R179Q/W mutations in the FGF23 (176)RXXR(179)/S(180) proteolytic cleavage motif can cycle from unaffected status to delayed onset of disease. This onset may occur in physiological states associated with iron deficiency, including puberty and pregnancy. To test the role of iron status in development of the ADHR phenotype, WT and R176Q-Fgf23 knock-in (ADHR) mice were placed on control or low-iron diets. Both the WT and ADHR mice receiving low-iron diet had significantly elevated bone Fgf23 mRNA. WT mice on a low-iron diet maintained normal serum intact Fgf23 and phosphate metabolism, with elevated serum C-terminal Fgf23 fragments. In contrast, the ADHR mice on the low-iron diet had elevated intact and C-terminal Fgf23 with hypophosphatemic osteomalacia. We used in vitro iron chelation to isolate the effects of iron deficiency on Fgf23 expression. We found that iron chelation in vitro resulted in a significant increase in Fgf23 mRNA that was dependent upon Mapk. Thus, unlike other syndromes of elevated FGF23, our findings support the concept that late-onset ADHR is the product of gene-environment interactions whereby the combined presence of an Fgf23-stabilizing mutation and iron deficiency can lead to ADHR.
Effects of solid lubricants on friction and wear behaviors of polyamide 6 (2011)

Abstract As solid lubricants, Polytetrafluoroethylene (PTFE), graphite, and ultra‐high molecular weight polyethylene (UHMWPE) can improve the tribological properties of PA6. The mechanical and the tribological properties of polyamide 6 (PA6) composites filled with solid lubricants were researched. The blended materials were injection molded to provide the test samples. Mechanical properties were studied in terms of the tensile strength and impact strength. Friction and wear experiments were run at a rotating speed of 1500 rpm and under loads of 40 and 160 N. The worn surfaces were examined using a scanning electron microscope. It was found that an improvement of tribological properties can be obtained by preparing PA6 composites, which was closely related to the varieties and the contents of solid lubricants added. At a load of 40 N, PTFE was the most effective to have reductions of both coefficient and mass wear rate, while at a load of 160 N, UHMWPE was the most helpful. The effects of Combination Solid Lubricants were also discussed. The results showed that synergistic reaction can be gained to modify the tribology capabilities of PA6. Moreover, the micrographs taken in the worn surface of PA6 composites revealed that adhesive wear, abrasive wear and fatigue wear occurred in this study. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
A Simple Method for Recording and Analyzing Serological Data (1978)

Titration endpoints from any 2-fold dilution series represent either true or modified base-2 logarithms and can be recorded conveniently by tube or dilution number. The simple arithmetic mean of titers thus expressed can be easily converted to geometric mean titer (GMT) by use of a table of antilogarithms, which is presented. This approach not only facilitates the handling of large volumes of data but also simplifies GMT calculation.
Formation, Properties, and Characterization of a Fully Reduced Fe<sup>II</sup>Fe<sup>II</sup>Form of Spinach (and Parsley) [2Fe-2S] Ferredoxin with the Macrocyclic Complex [Cr(15-aneN<sub>4</sub>)(H<sub>2</sub>O)<sub>2</sub>]<sup>2+</sup>as Reductant (1997)

Reduction of spinach and parsley ferredoxin FdI in the Fe(III)Fe(III) state with the 1,4,8,12-tetraazacyclopentadecane complex [Cr(15-aneN(4))(H(2)O)(2)](2+), here written as Cr(II)L, provides the first evidence for two 1-equiv steps yielding an Fe(II)Fe(II) product. Rate constants (25 degrees C) for spinach FdI are 2760 and 660 M(-)(1) s(-)(1), respectively, at pH 7.5, I = 0.100 M (NaCl). An important observation is that the Cr(III)L generated in the first step remains attached to the Fe(II)Fe(III) product and perturbs the protein active site sufficiently to make the second stage possible. The second Cr(II)L reduction is of the "outer-sphere" type, and the Cr(III)L generated is not attached to the protein. Anaerobic reoxidation of the fully reduced protein with [Co(NH(3))(6)](3+) is rapid and can be achieved with approximately 80% recovery of the Fe(III)Fe(III) oxidation state over 40 min. Air oxidation yields the Cr(III)L product Fe(III)Fe(III).Cr(III)L (Fe:Cr = 2:1). With Anabaena variabilis only a one-step reduction is observed and there is no Cr(III)L attachment. From a comparison of amino acid sequences with spinach (and parsley) FdI, a likely point of Cr(III)L attachment is indicated. Comparisons are made with dithionite as reductant. In addition, square-wave voltammetry on spinach Fe(III)Fe(III).Cr(III)L gives two reduction potentials -273 and -410 mV vs NHE. The different redox products have been characterized by EPR. Using (1)H NMR line-broadening techniques, evidence for Cr(III)L binding at a surface site close to Tyr-25/Tyr-82 is obtained. Also from investigations with redox-inactive [Cr(en)(3)](3+) as a competitive inhibitor for Cr(II)L reduction of spinach Fe(III)Fe(III), Tyr-25/Tyr-82 is proposed as the site for Cr(II)L reduction. From an extension of studies to include reduction of Fe(III)Fe(III).Cr(III)L with Cr(II)L, evidence is obtained for a second reaction site when that at Tyr-25/Tyr-82 is no longer available.
Intrathecal Clonidine in the Treatment of Intractable Pain: A Phase I/II Study (2002)

This study demonstrates the tolerability and effectiveness of intrathecal clonidine in the treatment of chronic pain. The physician using clonidine for long-term intrathecal infusion should be cognizant of the risk that severe rebound systemic hypertension can occur with abrupt cessation of the intrathecal infusion of clonidine.
Small Beam Bond Test Method for CFRP Composites Applied to Concrete (2010)

This paper presents the development of a test method that can be used to test the bond capacity of carbon fiber-reinforced polymer (CFRP) composites bonded to concrete. The rationale for the selection of the test method is described along with the results of the experimental work used to refine the test configuration and procedures. The research objectives were to develop a test method that (1) can be used to evaluate the durability of the FRP-concrete bond (adhesion failure mode); (2) facilitate multiple replicate for statistical validation; (3) is simple to conduct; and (4) provides comparative results that are easy to interpret. The method utilizes a small concrete beam modeled after the modulus of rupture test, which is typically used to measure concrete tensile strength. A number of small beam sizes and loading configurations were considered during the investigation. The final recommended specimen configuration is 4×4×14 in. (100 mm×100 mm×356 mm) beam with a half-depth saw cut at midspan. A 1 in. (25 mm) wide by 8 in. (203 mm) long CFRP strip is applied to the tension face of the beam over the saw cut. The specimen is loaded until failure with a single concentrated load at midspan over a 12 in. (305 mm) span. For durability testing, samples are prepared with the same materials and exposed to the desired accelerated conditioning protocol. Companion unexposed samples are also tested and the relative decrease in capacity is reported as the load to failure of the exposed specimen to that of the control specimen.
Consistent Video Filtering for Camera Arrays (2017)

Visual formats have advanced beyond single-view images and videos: 3D movies are commonplace, researchers have developed multi-view navigation systems, and VR is helping to push light field cameras to mass market. However, editing tools for these media are still nascent, and even simple filtering operations like color correction or stylization are problematic: naively applying image filters per frame or per view rarely produces satisfying results due to time and space inconsistencies. Our method preserves and stabilizes filter effects while being agnostic to the inner working of the filter. It captures filter effects in the gradient domain, then uses input frame gradients as a reference to impose temporal and spatial consistency. Our least-squares formulation adds minimal overhead compared to naive data processing. Further, when filter cost is high, we introduce a filter transfer strategy that reduces the number of per-frame filtering computations by an order of magnitude, with only a small reduction in visual quality. We demonstrate our algorithm on several camera array formats including stereo videos, light fields, and wide baselines.
Actuated hybrid mirrors for space telescopes (2010)

This paper describes new, large, ultra-lightweight, replicated, actively controlled mirrors, for use in space telescopes. These mirrors utilize SiC substrates, with embedded solid-state actuators, bonded to Nanolaminate metal foil reflective surfaces. Called Actuated Hybrid Mirrors (AHMs), they use replication techniques for high optical quality as well as rapid, low cost manufacturing. They enable an Active Optics space telescope architecture that uses periodic image-based wavefront sensing and control to assure diffraction-limited performance, while relaxing optical system fabrication, integration and test requirements. The proposed International Space Station Observatory seeks to demonstrate this architecture in space.
Effects of alendronate and taxol on PC-3 ML cell bone metastases in SCID mice. (1996)

The combined influence of alendronate, a bisphosphonate compound, and taxol on the establishment and growth of human PC-3 ML subclones injected intravenously via the tail vein in SCID mice was investigated. The pretreatment of SCID mice with alendronate (0.04-0.1 mg/kg twice weekly or 0.1 mg/kg weekly) partially blocked the establishment of bone metastases by human PC-3 ML cells and resulted in tumor formation in the peritoneum and other soft tissues. However, alendronate pretreatment of mice (0.1 mg/kg twice weekly or weekly) and dosing along with taxol (10-50 mg/kg/day, twice weekly, or weekly) blocked the growth of PC-3 ML tumors in the bone marrow and soft tissues in a statistically significant manner and improved survival rates significantly (p < 0.001) by 4-5 weeks. ELISAs and zymography of matrix metalloproteinase production in vitro and in vivo showed that alendronate and taxol alone partially inhibited metalloproteinase production, but that taxol in combination with alendronate totally blocked protease production and release. The combined activities of alendronate and taxol appeared to inhibit the establishment and growth of tumors in SCID mice, perhaps, in part, as a result of inhibition of protease production and release.
Round Robin Scheduling for Fair Flow Control in Data Communication Networks. (1986)

This thesis studies a simple strategy for fairly allocating link capacity in a point-to-point packet network with virtual circuit routing. Each link offers its packet transmission slots to its user sessions by polling them in round robin order. In addition, link-by-link window flow control is used to prevent excessive packet queues at the network nodes. As the window size increases, the session throughput rates are shown to approach limits that are perfectly fair the maxmin sense. That is, the smallest session rate in the network is a large as possible and, subject to that constraint, the second-smallest session rate is as large as possible, etc. If each session has evenly spaced packet arrivals or has such heavy demand that packets are always waiting to enter the network, then a finite window size suffices to produce perfectly fair throughout rates. (These properties do not hold if first-come-first-served scheduling is used instead of round robin.)
Changes in corneal curvature in accommodation (2003)

The results suggest that changes in corneal curvature in accommodation participate in the mechanism of accommodation.
An Assessment of Neutron Sensor Channel in-Situ Performance Testing Methods (1985)

An overall comparative assessment of in-situ methods for performance verification of neutron sensor channels is presented. This assessment includes ongoing research being conducted by the authors and their associates in the following techniques: modulation of the high voltage bias supply, analysis of detector signal noise, time domain reflectometry, and "traditional" methods such as saturation curve analysis. Results of an experimental program involving detector testing techniques in a laboratory and operating power reactor environment are discussed. Recommendations relative to the optimum methods available for a given test situation, as well as a possible "integrated" surveillance/testing program, are made.
Survey on XML-Based Policy Languages for Open Environments (2006)

Abstract: This paper reviews several XML based languages and analyses their suitability for use in a mobile policy environment for access control and Digital Rights Management. A set of essential features is identified and a comparison between the different proposals is presented, along with some conclusions on the suitability of each language to the new applications emerging on the Internet.
Large-Scale Analysis of Association Between <emph type="ital">LRP5</emph> and <emph type="ital">LRP6</emph> Variants and Osteoporosis (2008)

Common LRP5 variants are consistently associated with BMD and fracture risk across different white populations. The magnitude of the effect is modest. LRP5 may be the first gene to reach a genome-wide significance level (a conservative level of significance [herein, unadjusted P < 10(-7)] that accounts for the many possible comparisons in the human genome) for a phenotype related to osteoporosis.
A Novel Nuclear Function for the Interleukin-17 Signaling Adaptor Protein Act1 (2016)

In the context of the human airway, interleukin-17A (IL-17A) signaling is associated with severe inflammation, as well as protection against pathogenic infection, particularly at mucosal surfaces such as the airway. The intracellular molecule Act1 has been demonstrated to be an essential mediator of IL-17A signaling. In the cytoplasm, it serves as an adaptor protein, binding to both the intracellular domain of the IL-17 receptor as well as members of the canonical nuclear factor kappa B (NF-κB) pathway. It also has enzymatic activity, and serves as an E3 ubiquitin ligase. In the context of airway epithelial cells, we demonstrate for the first time that Act1 is also present in the nucleus, especially after IL-17A stimulation. Ectopic Act1 expression can also increase the nuclear localization of Act1. Act1 can up-regulate the expression and promoter activity of a subset of IL-17A target genes in the absence of IL-17A signaling in a manner that is dependent on its N- and C-terminal domains, but is NF-κB independent. Finally, we show that nuclear Act1 can bind to both distal and proximal promoter regions of DEFB4, one of the IL-17A responsive genes. This transcriptional regulatory activity represents a novel function for Act1. Taken together, this is the first report to describe a non-adaptor function of Act1 by directly binding to the promoter region of IL-17A responsive genes and directly regulate their transcription.
Sociological Treatise, Detective Story, Love Affair: The Film Versions of An American tragedy (1977)

The turn of the twentieth century saw the heyday of a new kind of novel, written by the school of so-called naturalists: in Europe, most notably Zola; and, in the United States, Stephen Crane, Frank Norris, and Theodore Dreiser.1 The maturity of naturalistic fiction and the infancy of film thus coincide: the emphasis placed by the naturalists on documentary detail, on representative characters with the quality of single-dimensional cartoons, and the appeal of these writers to a wide, proletarian audience, link the school of naturalistic novelists more than fortuitously to the emergent new art of cinema. The early filmmakers drew not only upon such proven stage successes as East Lynne and Uncle Tom's Cabin, or upon such immensely popular novels of the preceding age as those of Dickens. They turned as well for material to the contemporary novel; in particular to the naturalistic novel, with its larger than life characters, and its concern with maintaining an element of romance even in the midst of documentary realism (a colloca- tion which the chief American explicator of the genre, Norris, had insisted upon). In addition, to mention only the major directors, Griffith used Norris himself in A Corner in Wheat, DeMille used David Graham Phillips in Old Wives for New, and Stroheim used Norris again in Greed.
Segregation of Micrometer-Dimension Biosensor Elements on a Variety of Substrate Surfaces (2000)

With the rapid development of micro total analysis systems and sensitive biosensing technologies, it is often desirable to immobilize biomolecules to small areas of surfaces other than silicon. To this end, photolithographic techniques were used to derivatize micrometer-sized, spatially segregated biosensing elements on several different substrate surfaces. Both an interference pattern and a dynamic confocal patterning apparatus were used to control the dimensions and positions of immobilized regions. In both of these methods, a UV laser was used to initiate attachment of a photoactive biotin molecule to the substrate surfaces. Once biotin was attached to a substrate, biotin/avidin/biotin chemistry was used to attach fluorescently labeled or nonlabeled avidin and biotinylated sensing elements such as biotinylated antibodies. Dimensions of 2-10 microm were achievable with these methods. A wide variety of materials, including glassy carbon, quartz, acrylic, polystyrene, acetonitrile-butadiene-styrene, polycarbonate, and poly(dimethylsiloxane), were used as substrates. Nitrene- and carbene-generating photolinkers were investigated to achieve the most homogeneous films. These techniques were applied to create a prototype microfluidic sensor device that was used to separate fluorescently labeled secondary antibodies.
Validation of the Microlife BP 3BTO-A oscillometric blood pressure monitoring device according to a modified British Hypertension Society protocol (2002)

The Microlife can be recommended for clinical use in an adult population.
A quarter-micrometer interconnection technology using a TiN/Al-Si-Cu/TiN/Al-Si-Cu/TiN/Ti multilayer structure (1993)

An interconnection structure using a TiN/Al-1% Si-0.5% Cu/TiN/Al-1% Si-0.5% Cu/TiN/Ti multilayer conductor was investigated as a quarter-micrometer interconnection candidate for 256-Mb DRAMs. It was found that intermetallic compounds such as TiAl/sub x/ were formed at both grain boundaries of Al-Si-Cu and interfaces between Al-Si-Cu and TiN of the multilayer, resulting in both increase in Vickers hardness and suppression of stress relaxation. The multilayer conductor strip, which was covered with plasma-enhanced chemical vapor deposition silicon nitride (P-SiN), suppressed stress-induced voiding after heat treatment at 500 degrees C. Electromigration tests for quarter-micrometer wide multilayer strips indicated the improvement in the mean time to failure and the increase of the standard deviation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Tri-channel single-mode terahertz quantum cascade laser (2014)

We report on a compact THz quantum cascade laser source emitting at, individually controllable, three different wavelengths (92.6, 93.9, and 95.1 μm). This multiwavelength laser array can be used as a prototype of the emission source of THz wavelength division multiplex (WDM) wireless communication system. The source consists of three tapered single-mode distributed feedback (DFB) terahertz quantum cascade lasers fabricated monolithically on a single chip. All array elements feature longitudinal as well as lateral single-mode in the entire injection range. The peak output powers of individual lasers are 42, 73, and 37 mW at 10 K, respectively.