gebhart/patrepeval huggingface dataset:
Fluid resuscitation in acute pancreatitis (2016)

Alterations of the pancreatic microperfusion are an early event in the course of pancreatitis irrespective of the underlying etiology (10). They result in reduced blood flow, capillary leakage, pancreatic and peripancreatic edema and transmigration of inflammatory cells. The source of proinflammatory mediators leading to these events have not been fully identified, but studies indicate that acinar and stellate cells as well as resident immune cells can all respond to pancreatic injury by secreting proinflammatory cytokines such as IL-1b, IL-6 and TNF- (23). Ultimately the decreased microperfusion and activation of the endothelium will also lead to hypercoagulability which, in turn, aggravates pancreatic hypoperfusion and hypoxia. The lack of oxygen as well as reperfusion damage will lead to pancreatic necrosis with sometimes catastrophic consequences such as infected pancreatic collections, sepsis, bleeding and death (9). Systemically multiorgan failure due to systemic inflammatory response syndrome, hypoperfusion and shock are common events in severe forms of acute pancreatitis, leading to mortality rates close to 50% in some patient cohorts (2).
Spiral growth of GaAs by metalorganic vapor phase epitaxy (1994)

Growth spirals are observed on metalorganic vapor phase epitaxy grown GaAs surfaces by atomic force microscopy. The growth mechanism is according to the classical Burton–Cabrera–Frank theory. Spirals originate from screw dislocations. Successive turns of steps are sent out by the dislocations. These steps are of monolayer height (0.28 nm) and the interstep distance is around 150 nm. The spiral steps are well developed around the screw dislocations, while the adjacent vicinal steps lack the regularity of the spiral steps. Two-dimensional nucleation islands are also observed on the vicinal steps.
La Complejidad de la Complejidad (2001)

Philosophy and science come both from the same source: the need of mankind to comprehend the world. Greek philosophy, and all the civilization emerging from it, reveal the deep influence of a series of dualisms. At the basement of all of these, there is the distinction of what is true and what is false. Evidently, the world is not simple and there is not one universal explanation for all phenomena. However, Greek philosophers discovered that some phenomena could be understood and then predicted. They discovered that this comprehension of phenomena is achievable through the numerical structure sustaining all things; thus, if we get the knowledge of that numerical structure we can control the world. Pitagorian school of knowledge developed in this way a concern on mathematics that permeates western science until today.
Evaluating the potential of alternating phase-shift masks using lithography simulation (1999)

This paper quantifies the expected gain in the process window of 150nm structures printed with DUV for alt PSM vs. COG masks and HT PSM. Most of the analysis was performed for dense lines and isolated lines using lithography simulation. Alt PSM show an increase of dose latitude by 9 percent and an improved DOF by 0.2 micrometers for dense liens. For isolated lines the real advantage is seen in the increase of DOF by 0.7 micrometers . Furthermore it will be demonstrated, that alternating PSM can improve the imagin performance of contacts significantly over competitive techniques. Chromeless PSM may push the ultimate resolution limit. However to vary the linewidth three adjacent quartz edges must be used, since two phase edges are instable in defocus. A phase shifting region needs to exceed a minimum width in order to enhance the contrast of the aerial image of the whole feature. Experimental data and simulations show that the required minimum phase-shifter width for an isolated line is in the region of 400nm. Simulation and experiment show, that 90 degrees edges are very sensitive to defocus and neighboring patterns. Using a 3D mask simulator, correction values for etch depth and parameters for a lateral underetch were determined in order to achieve intensity balancing for alt PSM for various feature sizes.
DMA cache: Using on-chip storage to architecturally separate I/O data from CPU data for improving I/O performance (2010)

As technology advances both in increasing bandwidth and in reducing latency for I/O buses and devices, moving I/O data in/out memory has become critical. In this paper, we have observed the different characteristics of I/O and CPU memory reference behavior, and found the potential benefits of separating I/O data from CPU data. We propose a DMA cache technique to store I/O data in dedicated on-chip storage and present two DMA cache designs. The first design, Decoupled DMA Cache (DDC), adopts additional on-chip storage as the DMA cache to buffer I/O data. The second design, Partition-Based DMA Cache (PBDC), does not require additional on-chip storage, but can dynamically use some ways of the processor's last level cache (LLC) as the DMA cache. We have implemented and evaluated the two DMA cache designs by using an FPGA-based emulation platform and the memory reference traces of real-world applications. Experimental results show that, compared with the existing snooping-cache scheme, DDC can reduce memory access latency (in bus cycles) by 34.8% on average (up to 58.4%), while PBDC can achieve about 80% of DDC's performance improvements despite no additional on-chip storage.
Mehlich 3 soil test extractant: A modification of Mehlich 2 extractant (1984)

Abstract The objectives of this study were to modify the Mehlich 2 (M2) extractant to include Cu among the extractable nutrients, retain or enhance the wide range of soils for which it is suitable and minimize it's corrosive properties. The substitution of nitrate for chloride anions and the addition of EDTA accomplished those objectives. The new extracting solution, already designated Mehlich 3 (M3) is composed of 0.2N CH3COOH‐0.25N NH4N03‐0.015NNH4F‐0.013NHN03‐0.001M EDTA. Extractions from 105 soils using M3, M2, Bray 1 (Bl) and Ammonium Acetate (AA) were compared to evaluate the new extractant. The quantity of F extracted by M3 exceeded that by M2 20% and that by Bl 4% but the results from all extractions were highly correlated. Extractions of both K and Mg by M3 were 6–8% higher than those by AA and 3–4% higher than those by M2, but, again, there was high correlation among methods. Addition of EDTA increased Cu extractions by 170%, Mn by 50% and Zn by 25%. Cu extractions by M3 correlated with those from the Mehlich‐Bowling method. High correlations between Mn, as well as Zn, extracted by M3 and M2 were shown.
Accounting for representativeness errors in the inversion of atmospheric constituent emissions: application to the retrieval of regional carbon monoxide fluxes (2012)

A four-dimensional variational data assimilation system (4D-Var) is developed to retrieve carbon monoxide (CO) fluxes at regional scale, using an air quality network. The air quality stations that monitor CO are proximity stations located close to industrial, urban or traffic sources. The mismatch between the coarsely discretised Eulerian transport model and the observations, inferred to be mainly due to representativeness errors in this context, lead to a bias (average simulated concentrations minus observed concentrations) of the same order of magnitude as the concentrations. 4D-Var leads to a mild improvement in the bias because it does not adequately handle the representativeness issue. For this reason, a simple statistical subgrid model is introduced and is coupled to 4D-Var. In addition to CO fluxes, the optimisation seeks to jointly retrieveinfluence coefficients, which quantify each station's representativeness. The method leads to a much better representation of the CO concentration variability, with a significant improvement of statistical indicators. The resulting increase in the total inventory estimate is close to the one obtained from remote sensing data assimilation. This methodology and experiments suggest that information useful at coarse scales can be better extracted from atmospheric constituent observations strongly impacted by representativeness errors.
Results of the WMT19 Metrics Shared Task: Segment-Level and Strong MT Systems Pose Big Challenges (2019)

This paper presents the results of the WMT19 Metrics Shared Task.
Dielectric resonator antennas—a review and general design relations for resonant frequency and bandwidth (1994)

Abstract Open dielectric resonators (DRs) offer attractive features as antenna elements. These include their small size, mechanical simplicity, high radiation efficiency due to no inherent conductor loss, relatively large bandwidth, simple coupling schemes to nearly all commonly used transmission lines, and the advantage of obtaining different radiation characteristics using different modes of the resonator. In this article, we give a comprehensive review of the modes and the radiation characteristics of DRs of different shapes, such as cylindrical, cylindrical ring, spherical, and rectangular. Further, accurate closed form expressions are derived for the resonant frequencies, radiation Q‐factors, and the inside fields of a cylindrical DR. These design expressions are valid over a wide range of DR parameters. Finally, the techniques used to feed DR antennas are discussed. © 1994 John Wiley & Sons, Inc.
Validated high performance thin layer chromatography method for simultaneous estimation of ofloxacin and ornidazole in tablet dosage form (2006)

A simple, accurate and precise high performance thin layer chromatographic method has been developed for the estimation of ofloxacin and ornidazole simultaneously in tablet dosage form. The method employed silica gel 60GF254 precoated plates as stationary phase and a mixture of n-butanol: ethanol: ammonia (5:5:4 %v/v/v) as mobile phase. The plate was scanned and quantified at 295 nm using Camag TLC scanner. The method was validated for linearity, accuracy, precision, repeatability and specificity, proving its utility in estimation of ofloxacin and ornidazole in combined dosage form.
Fickian diffusion in glassy polymer‐solvent systems (1992)

Abstract A free‐volume theory is developed for the analysis of Fickian diffusion processes in glassy polymers. Equations are presented for the prediction of mutual diffusion coefficients in concentrated glassy polymer‐penetrant systems. The concentration dependence of the mutual diffusion coefficient is dependent on how much free volume the solvent contributes to the system and on how the addition of solvent affects the densification of the polymer matrix. © 1992 John Wiley & Sons, Inc.
Prophylactic Heparin in Patients with Severe Sepsis Treated with Drotrecogin Alfa (Activated) (2007)

Compared with placebo, concomitant prophylactic heparin was not equivalent, did not increase 28-day mortality, and had an acceptable safety profile in patients with severe sepsis receiving DrotAA. Heparin discontinuation should be carefully weighed in patients considered for DrotAA treatment. XPRESS clinical trial registered with www.clinicaltrials.gov (NCT 00049777). The study ID numbers are 6743; F1K-MC-EVBR.
Ghrelin Resistance Occurs in Severe Heart Failure and Resolves After Heart Transplantation (2009)

Heart failure may be associated with resistance to the appetite-stimulating effects of ghrelin, which may contribute to cachexia. Heart transplantation may be associated with resolution of ghrelin resistance, which may contribute to weight gain. These findings are preliminary and should be confirmed in larger trials.
THE BENEFICIAL EFFECT OF INTERMEDIATE NORMOTHERMIC PERFUSION DURING COLD STORAGE OF ISCHEMICALLY INJURED KIDNEYS (1989)

The effect of simple cold storage on ice with or without preceding warm ischemic injury on the energy metabolism and posttransplant viability of canine kidneys was examined in the present study. In addition, we investigated the possible beneficial effect of an intermediate normothermic perfusion half-way through the storage period on the preservation of ischemically injured kidneys. Thirty mongrel dogs were allocated to 5 experimental groups. In groups I and II kidneys were simply stored on ice for 24 and 48 hr, respectively. In groups III and IV kidneys were additionally subjected to 30 min warm ischemia before storage. In group 5 kidneys were treated as in group IV, but halfway through the storage period an intermediate normothermic ex-vivo perfusion was performed. The effect of these procedures on renal viability was tested by autologous reimplantation of the kidneys. During implantation the contralateral kidney was immediately removed. In group I all animals survived, whereas in group IV none of the animals survived. In groups II, III, and V, 2 of 6, 1 of 6, and 3 of 6 animals survived, respectively. The relationship, if any, between poststorage renal viability and the tissue levels of adenine nucleotides, guanine nucleotides, IMP, and purine degradation products was assessed by measuring the content of these metabolites in tissue specimen of the renal cortex, on which biopsies were done at various intervals during the experimental procedures. After an initial drop of about 30% in the content of adenine and guanine nucleotides and an increase in IMP, these values remained constant during 48 hr of cold storage. In contrast to kidneys stored for 24 hr, reimplantation of kidneys stored for 48 hr resulted in a significant decrease of adenine nucleotides following 60 min of in vivo reperfusion. Warm ischemia for 30 min prior to cold storage lead to lower initial nucleotide levels at the start of the storage period. During the first 24 hr nucleotide levels did not change, but a further decrease was observed during the following 24 hr of storage. Reimplantation after 24 hr of storage resulted in an additional decrease in the content of nucleotides. This poststorage decrease was absent after 48 hr of cold storage. Intermediate normothermic perfusion halfway through the storage for 48 hr significantly prevented the drop in the nucleotide content observed during the last 24 hr of storage in the corresponding control group. This nucleotide-sparing effect did not increase the level of nucleotides at the end of 60 min of reperfusion following reimplantation.(ABSTRACT TRUNCATED AT 400 WORDS)
Size-Selective Lewis Acid Catalysis in a Microporous Metal-Organic Framework with Exposed Mn<sup>2+</sup> Coordination Sites (2008)

Treatment of selected aldehydes and ketones with cyanotrimethylsilane in the presence of the microporous metal-organic framework Mn3[(Mn4Cl)3BTT8(CH3OH)10]2 (1, H3BTT = 1,3,5-benzenetristetrazol-5-yl) leads to rapid conversion to the corresponding cyanosilylated products. The transformation is catalyzed by coordinatively unsaturated Mn2+ ions that serve as Lewis acids and lead to conversion yields of 98 and 90% for benzaldehyde and 1-naphthaldehyde, the highest thus far for a metal-organic framework. Larger carbonyl substrates cannot diffuse through the pores of 1, and conversion yields are much lower for these, attesting to the heterogeneity of the reaction and its dependence on guest size. The Mukaiyama-aldol reaction, known to require much more active Lewis catalysts, is also catalyzed in the presence of 1, representing the first such example for a metal-organic framework. Conversion yields obtained for the reaction of selected aldehydes with silyl enolates reach 63%, on par with those obtained with zeolites. Size selectivity is demonstrated for the first time with this reaction through the use of larger silyl enolate substrates.
Knockdown of mutant K-ras expression by adenovirus-mediated siRNA inhibits the in vitro and in vivo growth of lung cancer cells (2006)

The ras mutation, which is observed in 20-30% of human nonsmall cell lung cancers (NSCLCs), is one of common genetic alterations and has been proposed to be a prognostic factor in lung cancer. Oncogene ras appears to be essential for tumor progression and maintenance. Several therapeutic agents have been developed to inhibit ras, such as FTIs and antisense oligonucleotides. A new tool for blocking oncogenes in cancer cells has emerged with the discovery that RNA interference can specifically silence expression of endogenous human genes. In the current study, we used small interfering RNA (siRNA) directed against mutant K-ras to determine the anti-tumor effects of decreasing the levels of this protein in lung cancer cell lines. Adenovirus-mediated siRNA (AdH1/siK-ras(V12)) against K-ras(V12) markedly decreased K-ras(V12) gene expression and inhibited cellular proliferation of NSCLC H441 cells that express the relevant mutation (K-ras codon 12 GGT --> GTT), but produced minimal growth inhibition on NSCLC H1650 cells that lack the relevant mutation. Pretreatment with AdH1/siK-ras(V12) completely abrogated subcutaneous engraftment of H441 cells, as compared with a 100% tumor take in animals that received control vector-treated tumor cells. The in vivo effect of AdH1/siK-ras(V12) treatment was further examined by intratumoral injections after tumor induction. Pre-existing tumor growth was reduced by 45% by a single intratumoral injection. Three or five repeat injections resulted in complete tumor regression in eight of ten nude mice. Further, 23.12% of AdH1/siK-ras(V12) treated H441 cells underwent apoptosis, as compared with 6.13%, and 8.27% in untreated and control vector-treated cells, respectively. These results indicate that adenovirus-mediated siRNA can specifically and efficiently target factors whose expression is altered in malignancy and may have the potential as a therapeutic modality to treat human lung cancer.
Application of particle swarm optimization for tuning the SVR parameters (2015)

the prediction of finger pinch force via surface electromyography (sEMG) signals is important in bionic control area. The purpose of this paper was to study how to improve the prediction accuracy while using support vector regression (SVR) to predict the pinch force. Four healthy subjects performed constant-posture force-varying pinch operations. The sEMG signal was acquired using two electrodes while the force signal was recorded by a JR3 sensor. The time domain feature of sEMG and the force signal were then applied as the input of the SVR model. In order to improve the prediction accuracy, the parameters of SVR model were optimized by applying particle swarm optimization (PSO) algorithm. The relative mean square error (RMSE), correlation coefficients (CC), and mean average error (MAE) were calculated as the criteria. The results show that the predicted force is close to the real pinch force by SVR modeling technique. The RMSE results are below 8% and the CC results are above 96% with 4 subjects. Compared with the grid search (GS) method, the PSO-SVR achieves a tradeoff between the accuracy and the computational costs with different kinds of training data.
Graphics processing unit-accelerated mesh-based Monte Carlo photon transport simulations (2019)

The mesh-based Monte Carlo (MMC) algorithm is increasingly used as the gold-standard for developing new biophotonics modeling techniques in 3-D complex tissues, including both diffusion-based and various Monte Carlo (MC)-based methods. Compared to multilayered and voxel-based MCs, MMC can utilize tetrahedral meshes to gain improved anatomical accuracy but also results in higher computational and memory demands. Previous attempts of accelerating MMC using graphics processing units (GPUs) have yielded limited performance improvement and are not publicly available. We report a highly efficient MMC-MMCL-using the OpenCL heterogeneous computing framework and demonstrate a speedup ratio up to 420× compared to state-of-the-art single-threaded CPU simulations. The MMCL simulator supports almost all advanced features found in our widely disseminated MMC software, such as support for a dozen of complex source forms, wide-field detectors, boundary reflection, photon replay, and storing a rich set of detected photon information. Furthermore, this tool supports a wide range of GPUs/CPUs across vendors and is freely available with full source codes and benchmark suites at http://mcx.space/#mmc.
Mineralization Induction of Gingival Fibroblasts and Construction of a Sandwich Tissue-Engineered Complex for Repairing Periodontal Defects (2018)

BACKGROUND The ideal healing technique for periodontal tissue defects would involve the functional regeneration of the alveolar bone, cementum, and periodontal ligament, with new periodontal attachment formation. In this study, gingival fibroblasts were induced and a "sandwich" tissue-engineered complex (a tissue-engineered periodontal membrane between 2 tissue-engineered mineralized membranes) was constructed to repair periodontal defects. We evaluated the effects of gingival fibroblasts used as seed cells on the repair of periodontal defects and periodontal regeneration. MATERIAL AND METHODS Primitively cultured gingival fibroblasts were seeded bilaterally on Bio-Gide collagen membrane (a tissue-engineered periodontal membrane) or unilaterally on small intestinal submucosa segments, and their mineralization was induced. A tissue-engineered sandwich was constructed, comprising the tissue-engineered periodontal membrane flanked by 2 mineralized membranes. Periodontal defects in premolar regions of Beagles were repaired using the tissue-engineered sandwich or periodontal membranes. Periodontal reconstruction was compared to normal and trauma controls 10 or 20 days postoperatively. RESULTS Periodontal defects were completely repaired by the sandwich tissue-engineered complex, with intact new alveolar bone and cementum, and a new periodontal ligament, 10 days postoperatively. CONCLUSIONS The sandwich tissue-engineered complex can achieve ideal periodontal reconstruction rapidly.
High aspect ratio polymer micro/nano-structure manufacturing using nanoembossing, nanomolding and directed self-assembly (2004)

This paper proposes three methods to fabricate synthetic gecko foot-hair high aspect ratio polymer micro/nano-structures. In the first method, nano-robotically indented templates are molded with liquid polymers, and the cured polymer is peeled off or etched away. Atomic force microscope and scanning tunneling microscope probe tips are used to emboss/indent flat wax surfaces, and silicone rubber micro/nano-bump structures are demonstrated. The second one uses a self-organized polycarbonate nano-pore membrane as the molding template. PDMS is molded into these micro/nano-pores under vacuum, and 1:2 and 1:9 aspect ratio pillar structures with 5 micron and 0.6 micron diameters are manufactured successfully. Finally, a directed self-assembly technique is proposed to grow regularly spaced and oriented micro/nano-pillars. Here, instability of a liquid polymer thin-film under a DC electric field is used to grow nano-pillars, and stretching and shearing of the grown hairs enable high aspect ratio and oriented hair structures. These hair structures will be utilized as novel biomimetic dry adhesives in future miniature space and surgical robot feet.