gebhart/patrepeval huggingface dataset:
Biological Effects of Estradiol-17β in Postmenopausal Women: Oral Versus percutaneous Administration (1986)

To determine whether the route of administration or the type of estrogen used in estrogen replacement therapy (ERT) is more important in avoiding effects on hepatic function,24 postmenopausal women were studied before and at the end of 2 months of oral or percutaneous administration of the same estrogen, estradiol-17β (E2). The treatments studied were oral micronized E2, 2 mg/day (9 women); oral E2 valerate, 2 mg/day (5 women), and percutaneous E2, 3 mg/day (10 women). Specific plasma biological and biochemical markers of estrogenic action were evaluated, namely, E2, estrone (E1), LH, FSH, sex steroid binding protein (SBP), renin substrate, antithrombin activity,and lipoproteins (high density lipoprotein cholesterol, low density lipoprotein cholesterol, very low density lipoprotein triglycerides).Both oral and percutaneous administration of E2 increased plasma E2 levels up to midfollicular values and decreased LH and FSH levels into the same range. Oral administration of E2 led to substantial increases in plasma Elf SBP, renin substrate, and VLDL levels, whereas AT decreased significantly. Percutaneous administration of E2 led to a physiological plasma E1/E2 ratio and did not induce any change in hepatic proteins. These data suggest that the route of administration of E2 determines the biochemical response to ERT in postmenopausal women. SBP is the most sensitive marker of the liver action of estrogen, and triglycerides also are simple and useful markers for this effect. Percutaneous E2 therapy is an effective method of ERT, and has no measurable effects on hepatic markers of estrogen action.
Restricted Adaptive Oblivious Transfer. (2008)

In this work we consider the following primitive, that we call restricted adaptive oblivious transfer. On the one hand, the owner of a database wants to restrict the access of users to this data according to some policy, in such a way that a user can only obtain information satisfying the restrictions imposed by the owner. On the other hand, a legitimate user wants to privately retrieve allowed parts of the data, in a sequential and adaptive way, without letting the owner know which part of the data is being obtained. After having formally described the components and required properties of a protocol for restricted adaptive oblivious transfer, we propose two schemes to realize this primitive. The first one is only of theoretical interest at the current time, because it uses a cryptographic tool which has not been realized yet: cryptosystems which are both multiplicatively and additively homomorphic. The second scheme, fully implementable, is based on secret sharing schemes.
Genomic Autobiographies of Chlamydiae (2014)

The genome sequences of Chlamydia trachomatis and C. pneumoniae contain the respective autobiographies that have been translated, read, and begun to be interpreted. The C. trachomatis species contains three biovariants: trachoma, lymphogranuloma venereum (LGV), and murine (MoPn). Strains of C. trachomatis that are natural pathogens of humans are members of either the trachoma or LGV biovar. Chlamydiae have substantial capacity for DNA repair and recombination, including mismatch repair (MutL, MutS, and three parologous MutY proteins), the excinuclease UvrABCD complex, transcription-repair coupling factor (TRCF), and a number of proteins implicated in recombination-coupled repair such as RecA, RecBCD, and RecJ. One of the phenotypic hallmarks of chlamydial development is the remarkably condensed nucleoid structure observed in elementary bodies (EB). The central metabolism determined for C. trachomatis and C. pneumoniae was found to be conserved. It appears that chlamydiae use fewer transport systems than free-living bacteria and rely on transport systems with broad specificity. The presence of an apparently complete glycolytic pathway was complemented by a tricarboxylic acid (TCA) cycle. The C. trachomatis genome contains genes encoding TrpA, TrpB, and TrpC, as well as a gene encoding a regulator of tryptophan gene transcription, TrpR. In the context of the unique biology and phylogeny of chlamydiae, the current challenges for productive microbiological research, and the medical imperative for progress in understanding chlamydial infection and disease, is that having a database available for the entire C. trachomatis and C. pneumoniae genomes will provide enduring benefits for chlamydial research.
The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone (2010)

Drug-drug interactions via CYP2D6 and CYP3A affected oxycodone pharmacokinetics and its magnitude depended on CYP2D6 genotype.
The Who Expert Committee on Drug Dependence (1979)

This report presents the recommendations of a WHO Expert Committee responsible for reviewing information on dependence-producing drugs to assess the need for their international control. The first part of the report contains a summary of the Committee's evaluations of seven substances (dronabinol, oripavine, buprenorphine, butorphanol, ketamine, khat and zopiclone). The report also discusses the substances that were pre-reviewed (gamma-hydroxybutyric acid and tramadol) and recommended gamma-hydroxybutyric acid for critical review at a future meeting. Two substances (gamma-butyrolactone and 1,4-butanediol) were identified for future pre-review). The second part of the report discusses the guidelines for the WHO review of dependence-producing psychoactive substances for international control. It includes sections on amending the current guidelines, interpretation of specific aspects of the guidelines and access to information necessary for the evaluation of substances. The final section considers other matters including activities of the EMCCDA, the use of pharmacovigilance data, promotion of education and information on the appropriate use of psychoactive drugs and the impact of international control on medical availability of substances.
Failure of secretin to prevent or ameliorate cerulein-induced pancreatitis in the rat. (1985)

Infusion of supramaximal concentrations of the synthetic pancreozymin analog cerulein induces acute edematous pancreatitis in the rat. Vacuolization and necrosis of acinar cells is paralleled by an almost complete reduction of pancreatic secretion from the cannulated duct. Preinfusion or coinfusion of synthetic secretin slightly increases pancreatic volume and protein secretion. This effect is only transient, and is always overcome by the actions of cerulein. Secretin does not prevent or improve the cellular destruction of the acinar cells. The results suggest that secretin has no beneficial effect on hormone-induced pancreatitis.
High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease (2013)

We argue that high ferritin levels may contribute to an accelerated pathology in AD. Our findings reinforce the importance of (unliganded) iron in AD, and suggest the possibility both of an early diagnosis and some means of treating or slowing down the progress of this disease.
Unusual spectroscopic and photophysical properties of meso-tert-butylBODIPY in comparison to related alkylated BODIPY dyes (2015)

<italic>meso-t</italic>-Bu-BODIPY produces unusual spectroscopic and photophysical characteristics in comparison to those of related alkylated BODIPY dyes.
Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection (2017)

Our results indicate that NP-exposure of persistently herpesvirus-infected cells - murine or human - restores molecular signatures found in acute virus infection, boosts production of lytic viral proteins, and induces an inflammatory response in the lung - a combination which might finally result in tissue damage and pathological alterations.
Introduction:  Molecular Conductors (2004)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTIntroduction: Molecular ConductorsPatrick BatailView Author Information CNRS-University of AngersCite this: Chem. Rev. 2004, 104, 11, 4887–4890Publication Date (Web):November 10, 2004Publication History Published online10 November 2004Published inissue 1 November 2004https://pubs.acs.org/doi/10.1021/cr040697xhttps://doi.org/10.1021/cr040697xeditorialACS PublicationsCopyright © 2004 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views5510Altmetric-Citations341LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (46 KB) Get e-AlertscloseSUBJECTS:Charge transfer,Electrical conductors,Materials,Metals,Salts Get e-Alerts
Node-disjoint path routing in wireless networks: tradeoff between path lifetime and total energy (2004)

Survivability and lifetime are two important issues related to routing in wireless ad-hoc networks. Routing using node-disjoint paths enhances both survivability and data confidentiality. An elegant polynomial time algorithm has been reported recently that can compute node-disjoint paths connecting a source node to a destination node with minimum total energy. However, the problem of computing a pair of node-disjoint paths connecting a source node to a destination node with a lifetime no smaller than a given threshold has not been studied before. In this paper, we present efficient algorithms for computing a pair of node-disjoint paths connecting a source node to a destination node which either minimizes energy under lifetime constraint or maximizes lifetime under energy consumption constraint. We study the tradeoffs between path lifetime and total energy consumption in node-disjoint path routing and their effects on network throughput and network lifetime. Our preliminary simulation results show that routing with both path lifetime and total energy consumption considerations leads to significantly better network throughput and network lifetime.
Total synthesis of cyclobutane amino acids from Atelia herbert smithii (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of cyclobutane amino acids from Atelia herbert smithiiPhilip Hughes and Jon ClardyCite this: J. Org. Chem. 1988, 53, 20, 4793–4796Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/jo00255a024https://doi.org/10.1021/jo00255a024research-articleACS PublicationsRequest reuse permissionsArticle Views1456Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of a Simple Morphing Wing Using Elastomeric Composites as Skins and Actuators (2009)

Morphing wings are desired for their ability to reduce drag, to change flight characteristics, and perhaps to reduce weight by eliminating flap/aileron mechanisms. Development of two generations of a morphing wing project is documented. The work shows how a relatively low cost but realistic morphing wing test-bed can be fabricated. Wing skin, actuator, and actuator attachment development are discussed, as well as possible auxetic skin behavior. Aerodynamic characterization of the wing will be discussed in another paper. A very simple morphing wing was fabricated in generation one. The nose was able to elastically camber down approximately 25 deg and the tail 20 deg. Actuation was provided by three pneumatic “rubber muscle actuators” that produce high contractive/tensile forces. Upper and lower wing skins were fabricated from carbon fiber/polyurethane elastomer laminates. Lower skin buckling, actuator air leaks, and actuator attachment problems were resolved in the second generation. A finite element model of the second wing was developed and is being used to refine the morphing wing test-bed. The second wing fabrication methodology enabled smooth elastic cambering with no buckling or waviness in the skins. The nose cambered down 14 deg and the tail cambered down to 13 deg, and is capable of larger deformations. Improved leak-free biomimetic actuators and attach points now include no metal parts and have higher actuation forces due to new braided sheaths and functionally gradient matrix properties.
Cationic Iridium(I) Complexes as Catalysts for the Alcoholysis of Silanes (2003)

The syntheses of five cationic iridium(I) complexes, containing the bidentate ligands bis(1-pyrazolyl)methane (BPM) and bis(3,5-dimethyl-1-pyrazolyl)methane (dmBPM), {[Ir(BPM)(COD)]+(BPh4)-} (1), {[Ir(dmBPM)(COD)]+(BPh4)-} (2), {[Ir(BPM)(COD)]+[Ir(COD)Cl2]-} (4), {[Ir(BPM)(CO)2]+(BPh4)-} (3), and {[Ir(dmBPM)(CO)2]+(BPh4)-} (5), are reported. The complexes were characterized by NMR spectroscopy, and the solid-state structure of {[Ir(BPM)(CO)2]+(BPh4)-} (3) was determined by single-crystal X-ray crystallographic analysis. The complexes {[Ir(BPM)(CO)2]+(BPh4)-} (3) and {[Ir(dmBPM)(CO)2]+(BPh4)-} (5) are effective catalysts for the alcoholysis of a range of alcohols and hydrosilanes, including secondary and tertiary hydrosilanes, under mild conditions.
Design Criteria for Optimum Performance of Conveyor Systems Used in Agricultural Production (1978)

This paper describes the problem of optimization as applied to the design and operation of conveying equipment such as belt or screw conveyors. The problem centres around the minimization of a cost or objective function which takes into account the costs associated with the energy consumption and overall efficiency of the conveyor, and the depreciation of the capital cost of the equipment; the latter includes all components of the system such as the conveyor, drive motor and gear reducer. By way of example, the paper describes the optimal design of screw or auger conveyors which are widely used for grain handling. Design information and optimal performance curves are presented.
Binding of small acid-soluble spore proteins from Bacillus subtilis changes the conformation of DNA from B to A. (1991)

Small acid-soluble spore proteins (SASPs) appear 3-4 hr after the onset of sporulation in Gram-positive bacteria and constitute up to 20% of the protein of mature spores. Previous studies using Bacillus subtilis deletion mutants lacking SASP-alpha and -beta have shown that such mutations abolish the elevated resistance of spores to UV radiation. Analyses using circular dichroism and Fourier-transform infrared spectroscopy now demonstrate that binding alpha/beta-type SASPs to DNA in vitro causes a structural change in DNA, from the B to the A conformation. This may provide the basis whereby alpha/beta-type SASPs confer increased spore UV resistance in vivo--by changing spore DNA conformation, they alter DNA photochemistry such that UV irradiation produces spore photoproduct instead of the more lethal cyclobutane-type thymine dimers.
Designing and implementing effective venous thromboembolism prevention protocols: lessons from collaborative efforts (2009)

Hospital acquired venous thromboembolism (VTE) is a major source of morbidity and mortality, yet proven prevention measures are often underutilized. The lack of a validated VTE risk assessment model, difficulty integrating VTE risk assessment and prevention protocols into the routine process of care, and the lack of standardized metrics for VTE prophylaxis have all been barriers. Recently, a VTE risk assessment/prevention protocol has been validated, leading to portable strategies achieving breakthrough levels of adequate prophylaxis in a variety of inpatient settings. VTE prevention protocol design and implementation strategies have been collected in implementation guides available from the Society of Hospital Medicine and the Agency for Healthcare Research and Quality. These guides were the centerpieces of national collaborative efforts to improve VTE involving over 150 medical centers, honing the approach to accelerate improvement described in this article. Embedding a VTE prevention protocol into admission, transfer, and perioperative order sets is a key strategy. A VTE prevention protocol is defined as a VTE risk assessment with no more than three levels of risk, tightly linked to recommended prophylaxis for each level. A balance between the need to provide protocol guidance and the need for efficiency and ease-of-use by the clinician must be maintained. The power of this protocol driven approach is bolstered by a quality improvement framework, multidisciplinary teams, ongoing monitoring of the process, and real time identification and mitigation of non-adherents via a technique that measures progress and prompts concurrent intervention, an approach we call "measure-vention."
Annexin A1: Uncovering the Many Talents of an Old Protein (2018)

Annexin A1 (ANXA1) has long been classed as an anti-inflammatory protein due to its control over leukocyte-mediated immune responses. However, it is now recognized that ANXA1 has widespread effects beyond the immune system with implications in maintaining the homeostatic environment within the entire body due to its ability to affect cellular signalling, hormonal secretion, foetal development, the aging process and development of disease. In this review, we aim to provide a global overview of the role of ANXA1 covering aspects of peripheral and central inflammation, immune repair and endocrine control with focus on the prognostic, diagnostic and therapeutic potential of the molecule in cancer, neurodegeneration and inflammatory-based disorders.
Hsp70 inhibits lipopolysaccharide‐induced NF‐κB activation by interacting with TRAF6 and inhibiting its ubiquitination (2006)

Inducible heat shock protein 70 (Hsp70) is one of the most important HSPs for maintenance of cell integrity during normal cellular growth as well as pathophysiological conditions. Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a crucial signaling transducer that regulates a diverse array of physiological and pathological processes and is essential for activating NF-kappaB signaling pathway in response to bacterial lipopolysaccharide (LPS). Here we report a novel mechanism of Hsp70 for preventing LPS-induced NF-kappaB activation in RAW264.7 macrophage-like cells. Our results show that Hsp70 can associate with TRAF6 physically in the TRAF-C domain and prevent TRAF6 ubiquitination. The stimulation of LPS dissociates the binding of Hsp70 and TRAF6 in a time-dependent manner. Hsp70 inhibits LPS-induced NF-kappaB signaling cascade activation in heat-shock treated as well as Hsp70 stable transfected RAW264.7 cells and subsequently decreases iNOS and COX-2 expression. Two Hsp70 mutants, Hsp70DeltaC(1-428aa) with N-terminal ATPase domain and Hsp70C(428-642aa) with C-terminal domain, lack the ability to influence TRAF6 ubiquitination and TRAF6-triggered NF-kappaB activation. Taken together, these findings indicate that Hsp70 inhibits LPS-induced NF-kappaB activation by binding TRAF6 and preventing its ubiquitination, and results in inhibition of inflammatory mediator production, which provides a new insight for analyzing the effects of Hsp70 on LPS-triggered inflammatory signal transduction pathways.
Fungal cellulase systems. Comparison of the specificities of the cellobiohydrolases isolated from <i>Penicillium pinophilum</i> and <i>Trichoderma reesei</i> (1989)

Reaction patterns for the hydrolysis of chromophoric glycosides from cello-oligosaccharides and lactose by the cellobiohydrolases (CBH I and CBH II) purified from Trichoderma reesei and Penicillium pinophilum were determined. They coincide with those found for the parent unsubstituted sugars. CBH I enzyme from both organisms attacks these substrates in a random manner. Turnover numbers are, however, low and do not increase appreciably as a function of the degree of polymerization of the substrates. The active-site topology of the CBH I from T. reesei was further probed by equilibrium binding experiments with cellobiose, cellotriose, lactose and some of their derivatives. These point to a single interaction site (ABC), spatially restricted as deduced from the apparent independency of the thermodynamic parameters. It appears that the putative subsite A can accommodate a galactopyranosyl or glucopyranosyl group, and subsite B a glucopyranosyl group, whereas in subsite C either a glucopyranosyl or a chromophoric group can be bound, scission occurring between subsites B and C. The apparent kinetic parameters (turnover numbers) for the hydrolysis of cello-oligosaccharides (and their derivatives) by the CBH II type enzyme increase as a function of chain length, indicative of an extended binding site (A-F). Its architecture allows for specific binding of beta-(1----4)-glucopyranosyl groups in subsites A, B and C. Binding of a chromophore in subsite C produces a non-hydrolysable complex. The thermodynamic interaction parameters of some ligands common to both type of enzyme were compared: these substantiate the conclusions reached above.
Stereoselective Functionalization of 2‐(1‐Aminoalkyl)aziridines via Lithiation of Aziridine–Borane Complexes (2005)

Highly selective functionalization of the aziridine ring of (2S,1'S)-2-(1'-aminoalkyl)aziridines 1, through successive formation of aziridine-borane complexes, lithiation, treatment with a variety of electrophiles and final decomplexation is described. The influence of the structure of the starting complexes 2 and of the electrophiles in the stereoselectivity of this process has been studied. Finally, successive double lithiation-electrophile reactions were carried out affording enantiopure 1,2,3,3-tetrasubstituted aziridine-borane complexes with high selectivity.
Galectin-1 modulates the migration level and the aggressiveness of human glioblastoma cells in vitro and in vivo. (2002)

info:eu-repo/semantics/nonPublished