gebhart/patrepeval huggingface dataset:
IEEE 1149 standards - Changing testing, silicon to systems (2002)

After an introduction to IEEE standards development, the five active standards projects in the IEEE 1149 family are described briefly. Some just promulgated changes to ANSI/IEEE Std 1149.1 are presented. Among these changes are two new optional instructions intended to aid testing of product which require both in-circuit and boundary-scan testing and subordination of the 1149.1 Test Access Port to higher level test control. Updates on the status of IEEE P1149.2 and IEEE P1149.5 are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Two behavioral states studied in a single PET/FDG procedure: theory, method, and preliminary results. (1987)

We have developed a method that allows two sets of regional cerebral metabolic rates of glucose (rCMRglc) to be obtained in a single extended procedure using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG). This is an adaptation of the deoxyglucose method, with the addition of a second injection of FDG immediately after completion of the first scan, then followed 30 min later by a second scan. A model has been developed to allow for correction of measured tracer concentration in the second scan by subtracting the predicted remnant from the first scan. The possible applications of this method in studying behavior-metabolism relationships are demonstrated. The preliminary results show 6%-12% changes in rCMRglc values for appropriate brain regions when the behavioral state is altered, but show 0%-5% change in rCMRglc values when the behavioral state is unchanged. The method can contribute significantly to the understanding of behavior-metabolism relationships by allowing the noninvasive study of two behavioral states in a single PET procedure.
Infrared spectral distribution of photoconductivity and up-conversion in GaP light emitting diodes (1985)

The spectral distribution of photoconductivity and infrared excited electroluminescence has been determined in GaP light emitting diodes at low temperatures by conventional infrared spectroscopic techniques. The observed photoresponse was found to be caused by ionization of shallow donors only, showing a peak sensitivity of 20 mA/W at 13-μm wavelength. Spectral structures for photon energies lower than the binding energies of shallow donors are attributed to electric field assisted photoionization. An external quantum efficiency of 3×10−3 was obtained being largely independent on the bias voltage and the wavelength of infrared stimulation.
Compositional Effects in Nanostructured Yttria Partially Stabilized Zirconia (2010)

There is a considerable current interest in learning how to process genuinely nanostructured ceramics as they offer the potential for significantly enhanced properties; however, it is often difficult to make large enough components to allow more than the most basic of property measurements. In this work, densified components measuring up to 50 mm in size have been produced and a number of very interesting properties have been measured and demonstrated.
DOTAGA–Anhydride: A Valuable Building Block for the Preparation of DOTA‐Like Chelating Agents (2012)

A DOTA derivative that contains an anhydride group was readily synthesized by reacting DOTAGA with acetic anhydride and its reactivity was investigated. Opening the anhydride with propylamine led to the selective formation of one of two possible regioisomers. The structure of the obtained isomer was unambiguously determined by 1D and 2D NMR experiments, including COSY, HMBC, and NOESY techniques. This bifunctional chelating agent offers a convenient and attractive approach for labeling biomolecules and, more generally, for the synthesis of a large range of DOTA derivatives. The scope of the reaction was extended to prepare DOTA-like compounds that contained various functional groups, such as isothiocyanate, thiol, ester, and amino acid moieties. This versatile building block was also used for the synthesis of a bimodal tag for SPECT or PET/optical imaging.
The Effect of the Speed of Rotation on the Electrode Potentials of Copper and Zinc (1937)

A quantitative study is presented of the effect on the metal electrode potential upon rotating the electrode at high speeds (8,000 r.p.m.). Two metals were investigated: copper and zinc. As the speed of rotation increased, the potentials of both the copper and the zinc became more noble—to as much as 9 to 15 millivolts respectively at 25° C. The magnitude of this change in potential depends upon the ion concentration. Results are in accord with the theory of Procopiu: Rotation brings about a change in the ion concentration in the liquid layers next the electrode. We observed a distinct rise in potential (becoming more noble) whenever the motor rotating the cathode was suddenly stopped.
The Genome of Canarypox Virus (2003)

Here we present the genomic sequence, with analysis, of a canarypox virus (CNPV). The 365-kbp CNPV genome contains 328 potential genes in a central region and in 6.5-kbp inverted terminal repeats. Comparison with the previously characterized fowlpox virus (FWPV) genome revealed avipoxvirus-specific genomic features, including large genomic rearrangements relative to other chordopoxviruses and novel cellular homologues and gene families. CNPV also contains many genomic differences with FWPV, including over 75 kbp of additional sequence, 39 genes lacking FWPV homologues, and an average of 47% amino acid divergence between homologues. Differences occur primarily in terminal and, notably, localized internal genomic regions and suggest significant genomic diversity among avipoxviruses. Divergent regions contain gene families, which overall comprise over 49% of the CNPV genome and include genes encoding 51 proteins containing ankyrin repeats, 26 N1R/p28-like proteins, and potential immunomodulatory proteins, including those similar to transforming growth factor beta and beta-nerve growth factor. CNPV genes lacking homologues in FWPV encode proteins similar to ubiquitin, interleukin-10-like proteins, tumor necrosis factor receptor, PIR1 RNA phosphatase, thioredoxin binding protein, MyD116 domain proteins, circovirus Rep proteins, and the nucleotide metabolism proteins thymidylate kinase and ribonucleotide reductase small subunit. These data reveal genomic differences likely affecting differences in avipoxvirus virulence and host range, and they will likely be useful for the design of improved vaccine vectors.
Experimental aerodynamics of a rotor entry vehicle (1968)

Aerodynamic performance tests of autorotative unpowered rotor entry vehicle model at various Mach numbers and angles of attack
Preparation, characterization and application of star-shaped PCL/PEG micelles for the delivery of doxorubicin in the treatment of colon cancer (2013)

Star-shaped polymer micelles have good stability against dilution with water, showing promising application in drug delivery. In this work, biodegradable micelles made from star-shaped poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymer were prepared and used to deliver doxorubicin (Dox) in vitro and in vivo. First, an acrylated monomethoxy poly (ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) diblock copolymer was synthesized, which then self-assembled into micelles, with a core-shell structure, in water. Then, the double bonds at the end of the PCL blocks were conjugated together by radical polymerization, forming star-shaped MPEG-PCL (SSMPEG-PCL) micelles. These SSMPEG-PCL micelles were monodispersed (polydispersity index = 0.11), with mean diameter of ≈25 nm, in water. Blank SSMPEG-PCL micelles had little cytotoxicity and did not induce obvious hemolysis in vitro. The critical micelle concentration of the SSMPEG-PCL micelles was five times lower than that of the MPEG-PCL micelles. Dox was directly loaded into SSMPEG-PCL micelles by a pH-induced self-assembly method. Dox loading did not significantly affect the particle size of SSMPEG-PCL micelles. Dox-loaded SSMPEG-PCL (Dox/SSMPEG-PCL) micelles slowly released Dox in vitro, and the Dox release at pH 5.5 was faster than that at pH 7.0. Also, encapsulation of Dox in SSMPEG-PCL micelles enhanced the anticancer activity of Dox in vitro. Furthermore, the therapeutic efficiency of Dox/SSMPEG-PCL on colon cancer mouse model was evaluated. Dox/SSMPEG-PCL caused a more significant inhibitory effect on tumor growth than did free Dox or controls (P < 0.05), which indicated that Dox/SSMPEG-PCL had enhanced anticolon cancer activity in vivo. Analysis with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) showed that Dox/SSMPEG-PCL induced more tumor cell apoptosis than free Dox or controls. These results suggested that SSMPEG-PCL micelles have promising application in doxorubicin delivery for the enhancement of anticancer effect.
Fibroblast Growth Factor-2 Stimulation of p42/44MAPKPhosphorylation and IκB Degradation Is Regulated by Heparan Sulfate/Heparin in Rat Mammary Fibroblasts (2000)

Fibroblast growth factor-2 (FGF-2) interacts with a dual receptor system consisting of tyrosine kinase receptors and heparan sulfate proteoglycans (HSPGs). In rat mammary fibroblasts, FGF-2 stimulated DNA synthesis and induced a sustained phosphorylation of p42/44(MAPK) and of its downstream target, p90(RSK). Moreover, FGF-2 also stimulated the transient degradation of IkappaBalpha and IkappaBbeta. PD098059, a specific inhibitor of p42/44(MAPK) phosphorylation, inhibited FGF-2-stimulated DNA synthesis, phosphorylation of p42/44(MAPK) and p90(RSK), and degradation of IkappaBbeta. In contrast, in chlorate-treated and hence sulfated glycosaminoglycan-deficient cells, FGF-2 was unable to stimulate DNA synthesis. However, FGF-2 was able to trigger a transient phosphorylation of both p42/44(MAPK) and p90(RSK), which peaked at 15 min and returned to control levels at 30 min. In these sulfated glycosaminoglycan-deficient cells, no degradation of IkappaBalpha and IkappaBbeta was observed after FGF-2 addition. However, in chlorate-treated cells, the addition of heparin or purified HSPGs simultaneously with FGF-2 restored DNA synthesis, the sustained phosphorylation of p42/44(MAPK) and p90(RSK), and the degradation of IkappaBalpha and IkappaBbeta. These results suggest that the HSPG receptor for FGF-2 not only influences the outcome of FGF-2 signaling, e.g. cell proliferation, but importantly regulates the immediate-early signals generated by this growth factor.
Current prognosis in overt neonatal hydrocephalus (1982)

Chiefly because of advances in prenatal diagnostic ultrasonography, prognostic data on congenital hydrocephalus have increased in pertinence. Neurosurgeons may be confronted with requests for prognostic information after discovery of gestational hydrocephalus. Because previous reports reflect technical problems, complications, and less favorable results of an evolutionary period in hydrocephalus therapy, the authors have attempted to update the prognostic picture with a review of their results in hydrocephalus that is overt at birth. the status of 37 children treated with cerebrospinal fluid shunts after delivery at term with overt hydrocephalus was evaluated after an average 6-year follow-up period. They represented 8% of all children being followed for hydrocephalus. Outcome was also reviewed in 11 patients with severe hydrocephalus who were not treated. Of treated patients, 86% survived 1 to 16 years, while all of the untreated infants died at an average of 2.5 months. Approximately two-thirds of treated patients have normal or borderline intellectual capabilities (mean IQ 96, standard deviation 22). Dandy-Walker malformation was associated with a high mortality and a very low IQ in survivors. Congenital aqueductal atresia was also associated with intellectual impairment, but children with communicating hydrocephalus and myelomeningocele were not intellectually impaired. Among the survivors with low IQ, the poor outcome was generally predictable on the basis of cortical mantle thickness and "brain mass" calculations before therapy. The findings from this partially selected series indicate that the majority of babies born with overt hydrocephalus have a good prognosis with appropriate therapy.
Terpene Compounds as Drugs. III. Terpenylketoximes (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTerpene Compounds as Drugs. III. TerpenylketoximesGianfranco. Pala, Antonio. Mantegani, and Germano. CoppiCite this: J. Med. Chem. 1967, 10, 5, 980Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://doi.org/10.1021/jm00317a066RIGHTS & PERMISSIONSArticle Views61Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (156 KB) Get e-Alertsclose Get e-Alerts
DNA Nicks Promote Efficient and Safe Targeted Gene Correction (2011)

Targeted gene correction employs a site-specific DNA lesion to promote homologous recombination that eliminates mutation in a disease gene of interest. The double-strand break typically used to initiate correction can also result in genomic instability if deleterious repair occurs rather than gene correction, possibly compromising the safety of targeted gene correction. Here we show that single-strand breaks (nicks) and double-strand breaks both promote efficient gene correction. However, breaks promote high levels of inadvertent but heritable genomic alterations both locally and elsewhere in the genome, while nicks are accompanied by essentially no collateral local mutagenesis, and thus provide a safer approach to gene correction. Defining efficacy as the ratio of gene correction to local deletion, nicks initiate gene correction with 70-fold greater efficacy than do double-strand breaks (29.0±6.0% and 0.42±0.03%, respectively). Thus nicks initiate efficient gene correction, with limited local mutagenesis. These results have clear therapeutic implications, and should inform future design of meganucleases for targeted gene correction.
Secretory Leukocyte Protease Inhibitor (SLPI) Is, like Its Homologue Trappin-2 (Pre-Elafin), a Transglutaminase Substrate (2011)

Human lungs contain secretory leukocyte protease inhibitor (SLPI), elafin and its biologically active precursor trappin-2 (pre-elafin). These important low-molecular weight inhibitors are involved in controlling the potentially deleterious proteolytic activities of neutrophil serine proteases including elastase, proteinase 3 and cathepsin G. We have shown previously that trappin-2, and to a lesser extent, elafin can be linked covalently to various extracellular matrix proteins by tissue transglutaminases and remain potent protease inhibitors. SLPI is composed of two distinct domains, each of which is about 40% identical to elafin, but it lacks consensus transglutaminase sequence(s), unlike trappin-2 and elafin. We investigated the actions of type 2 tissue transglutaminase and plasma transglutaminase activated factor XIII on SLPI. It was readily covalently bound to fibronectin or elastin by both transglutaminases but did not compete with trappin-2 cross-linking. Cross-linked SLPI still inhibited its target proteases, elastase and cathepsin G. We have also identified the transglutamination sites within SLPI, elafin and trappin-2 by mass spectrometry analysis of tryptic digests of inhibitors cross-linked to mono-dansyl cadaverin or to a fibronectin-derived glutamine-rich peptide. Most of the reactive lysine and glutamine residues in SLPI are located in its first N-terminal elafin-like domain, while in trappin-2, they are located in both the N-terminal cementoin domain and the elafin moiety. We have also demonstrated that the transglutamination substrate status of the cementoin domain of trappin-2 can be transferred from one protein to another, suggesting that it may provide transglutaminase-dependent attachment properties for engineered proteins. We have thus added to the corpus of knowledge on the biology of these potential therapeutic inhibitors of airway proteases.
Nitric Oxide: A Unique Endogenous Signaling Molecule in Vascular Biology (1999)

The properties of nitric oxide as an endogenous cell signaling molecule in vascular biology are described.
Evaluation of the Thermal Inactivation Kinetics of Surrogate Vegetative Bacteria (2015)

Microbial surrogates are defined as non-pathogenic organisms with behavioral and/or survival characteristics correlating to those of specific pathogens. The purpose of this study was to determine the thermal inactivation kinetics (D and z-values) of Lactobacillus bulgaricus ATCC 11842, Lactobacillus fructivorans ATCC 8288, Lactobacillus plantarum ATCC 4008, Listeria innocua ATCC 33091, ATCC 51742, and 11/97, and Staphylococcus carnosus CS-299 as potential surrogates for hepatitis A virus (HAV; D72°C = 0.9 min). Additionally, the effect of sub-lethal heat on increasing the thermotolerance of L. bulgaricus was investigated. All strains were tested in phosphate buffered saline (PBS) as a preliminary step and, contingent upon the survival characteristics, further tested in ultra-high temperature (UHT) 2% fat milk and chopped spinach. Thermal inactivation experiments in PBS, UHT milk, and chopped spinach were performed at a temperature range of 58-70°C for 0-60 min. For sub-lethal heating, L. bulgaricus was subjected to 45 or 50°C for 30 min prior to inoculation of milk and subsequent heating at 70°C. L. fructivorans, L. plantarum, and all L. innocua strains had insufficient thermal resistance to be used for HAV surrogates. In contrast, D-values for L. bulgaricus in UHT milk were 9.98, 2.68, and 0.45 min, at 65, 67, and 70 C, respectively, with a z-value of 3.7°C. When subjected to sub-lethal heating, the D70 C values for the 45 or 50 C treatment were 0.34 or 0.48 min, respectively. Thus sub-lethal heating did not increase thermal resistance. D-values for L. bulgaricus in spinach were 43.29, 10.13, 3.20, 0.91 min for 63, 65, 67, 70°C. S. carnosus had D-values in PBS of 3.46, 1.27, and 0.47 min at
Comment on the Sequential and Indeterminate Behavior of an End-Around-Carry Adder (1977)

The sequential and indeterminate behavior of an end-around-carry (EAC) adder is examined. This behavior is commonly overlooked in the literature. Design modifications to impose determinism are provided. These modifications also eliminate the troublesome negative zero found in the one's complement number system.
On a High-Speed Hough Transform Algorithm MRHT. (1998)

Line detection using Hough transform is one of the robust image processing methods for noisy images. Hut Hough t,ransform has a problem whose computation cost is very large in general. In order to ease this problem, many high-speed algorithms had been proposed. In this paper, we propose a new high-speed algorithm called MRHT (Multiple Randomized Hough Transform) which combines randomized edge point selection process of RHT and block division process of CIIT. And we clarify experimentally and theoretically that the MRHT is faster than RHT and CHT.
LC–MS Based Cleavage Site Profiling of the Proteases ADAM10 and ADAM17 Using Proteome-Derived Peptide Libraries (2014)

A Disintegrin and Metalloproteinase 10 (ADAM10) and ADAM17 catalyze ectodomain shedding of a number of cell surface proteins important for embryonic development and tissue homeostasis. Changes in the expression levels or dysregulated proteolytic activity of ADAM10 and ADAM17 have been shown to play important roles in multiple diseases such as inflammation, cancer, and neurodegenerative disorders. Despite the well documented substrate repertoire of ADAM10 and ADAM17, little is known about their cleavage site specificity. We optimized Q-PICS (Quantitative Proteomics for the Identification of Cleavage Sites) to elucidate the cleavage site specificity of recombinant murine ADAM10 and ADAM17. Two different yeast proteome-derived peptide libraries were used and samples were analyzed by LC-MALDI and LC-ESI MS in parallel. We show that the largest difference in the cleavage site specificities of ADAM10 and ADAM17 is at the P1' site: while both enzymes cleave N-terminal of leucine, only ADAM10 shows additional preference toward aromatic amino acids, whereas ADAM17 exhibits the highest preference for valine. Together with further amino acid preferences more adjacent to the scissile bond, our data is in good agreement with ADAM10/17 cleavage sites previously identified in native substrates. Overall, the precise identification of ADAM10 and ADAM17 cleavage site specificity provides the basis for better substrate identification in vivo and the generation of specific inhibitors or activity based probes.
A 152mW Mobille Multimedia SoC with Fully Programmable 3D Graphics and MPEG4/H.264/JPEG (2007)

We present a 152mW multimedia SoC with MPEG4 codec, H.264 decoder, JPEG codec and fully programmable 3D graphics for mobile applications. The unified shader in 3D graphics engine provides fully programmable 3D graphics with 35% area and 28% power reduction. Logarithmic lighting engine and the specialized lighting instruction give 9.1Mvertices/s vertex fill rate. The merged JPEG/MPEG4 codec and the unified shader reduce the silicon area further and the SoC consumes 6.4mm × 6.4mm in 0.13μm CMOS logic process.
Review Article Radiosynthesis of [18F]Trifluoroalkyl Groups: Scope and Limitations (2016)

License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The present paper is concerned with radiochemical methodology to furnish the trifluoromethyl motif labelled with 18F. Literature spanning the last four decades is comprehensively reviewed and radiochemical yields and specific activities are discussed. 1.