gebhart/patrepeval huggingface dataset:
Transforming growth factor beta down-regulates Src family protein tyrosine kinase signaling pathways. (1994)

Transforming growth factor beta (TGF beta) inhibits the proliferation of a wide range of cell types through interaction with its cell surface receptor (R-TGF beta). R-TGF beta possesses serine/threonine kinase activity rather than the tyrosine kinase activity normally associated with peptide growth factor receptors; nevertheless, TGF beta triggers a signaling pathway that leads to the repression of transcription factors, which appear to mediate the action of receptor tyrosine kinases within the nucleus. Accumulating evidence has also shown that the nonreceptor protein tyrosine kinases of the Src family play essential roles in the signal transduction pathways that regulate cell proliferation, differentiation, and function. Here, we investigate whether signals initiated by R-TGF beta are transduced, at least in part, through members of the Src family of tyrosine kinases. Treatment of the responsive human prostate carcinoma cell line PC3 with TGF beta induces a rapid and specific decrease in cellular levels of pp60Src and pp53/56Lyn and a corresponding decrease in their protein kinase activity when the assays were performed in vitro using the exogenous substrate enolase. Consistent with suppression of pp60Src and pp53/56Lyn kinase activity, TGF beta also caused a substantial intracellular accumulation of the unphosphorylated form of SH2-containing protein (SHC), a substrate of the Src family kinases. This was paralleled by decreased formation of a complex between the adaptor protein known as growth factor receptor-bound protein 2 and SHC. These results suggest, for the first time, that TGF beta induces down-regulation of Src family kinases, leading to disruption of the SHC-growth factor receptor-bound protein 2 complex. These events may play a crucial role in the negative regulation of Ras, as well as in the control of downstream effector molecules involved in the regulation of cell growth.
Gasification of n-C7 asphaltenes using Ni-based catalysts (2017)

Catalytic performance of two Ni-based catalysts (Ni-Pt and Ni-Pt-Al) in steam gasification of n-C7 asphaltenes (C7A) was examined. The influence of the catalysts composition and operating parameters (residence time and temperature) on hydrogen yield and char conversion was studied showing a high hydrogen production and a low char formation compared to Ni-Pt alone. From the result of the gasification of rice C7A over Ni-Pt/Ni-Pt-Al catalysts, it is found that the raising the Pt/Ni ratio increases the quantity of generated hydrogen, but this increase is greater in the presence of the Ni-Pt-Al catalyst because the tar cracking process improves with increased collisions and also with improved activation energies of the reactions in the presence of Al.
Susceptibility mapping as a means to visualize veins and quantify oxygen saturation (2010)

Susceptibility maps can successfully create venograms of the brain with varying levels of contrast-to-noise depending on the size of the vessel. Partial volume effects render this approach more useful as an imaging tool or a visualization tool, although certain larger vessels have measured susceptibilities close to expected values associated with normal blood oxygen saturation levels.
<title>Temperature distributions in laser-irradiated tissues</title> (1991)

Continuous wave (cw) hydrogen fluoride (HF) chemical laser interactions with human corneal tissue have been studied in order to understand tissue heating phenomenology, effects, and mechanisms under well- characterized laser irradiation conditions. Time-resolved tissue front surface temperature measurements have been obtained during laser irradiation using an optical pyrometer system. Both front surface and in-depth temperature distributions have been calculated by 1D and 2D heat transfer models using realistic tissue optical and thermal properties data for comparison with experiment. The combined experimental/modeling results are useful for developing safe and effective laser microsurgical heating procedures.
Exploiting Local Similarity to Efficiently Index Paths in Graph-Structured Data (2002)

XML and other semi-structured data may have partially speciﬁed or missing schema information, motivating the use of a structural summary which can be automatically computed from the data. These summaries also serve as indices for evaluating the complex path expressions common to XML and semi-structured query languages. However, to answer all path queries accurately, summaries must encode information about long, seldom-queried paths, leading to increased size andcomplexity with little addedvalue. We introduce the A(k)-indices, a family of approximate structural summaries. They are based on the concept of k-bisimilarity, in which nodes are grouped based on local structure, i.e., the incoming paths of length up to k. The parameter k thus smoothly varies the level of detail (and accuracy) of the A(k)-index. For small values of k, the size of the index is substantially reduced. While smaller, the A(k) index is approximate, and we describe techniques for efﬁciently extracting exact answers to regular path queries. Our experiments show that, for moderate values of k, path evaluation using the A(k)-index ranges from being very efﬁcient for simple queries to competitive for most complex queries, while using signiﬁcantly less space than comparable structures.
Modification of Barrier Properties of Polymeric Films of LDPE and HDPE by Cold Plasma Treatment (1995)

Article Modification of Barrier Properties of Polymeric Films of LDPE and HDPE by Cold Plasma Treatment was published on April 1, 1995 in the journal Journal of Polymer Engineering (volume 14, issue 2-3).
Bioinspired twisted composites based on Bouligand structures (2016)

The coupling between structural support and protection makes biological systems an important source of inspiration for the development of advanced smart composite structures. In particular, some particular material configurations can be implemented into traditional composites in order to improve their impact resistance and the out-of-plane properties, which represents one of the major weakness of commercial carbon fibres reinforced polymers (CFRP) structures. Based on this premise, a three-dimensional twisted arrangement shown in a vast multitude of biological systems (such as the armoured cuticles of Scarabei, the scales of Arapaima Gigas and the smashing club of Odontodactylus Scyllarus) has been replicated to develop an improved structural material characterised by a high level of in-plane isotropy and a higher interfacial strength generated by the smooth stiffness transition between each layer of fibrils. Indeed, due to their intrinsic layered nature, interlaminar stresses are one of the major causes of failure of traditional CFRP and are generated by the mismatch of the elastic properties between plies in a traditional laminate. Since the energy required to open a crack or a delamination between two adjacent plies is due to the difference between their orientations, the gradual angle variation obtained by mimicking the Bouligand Structures could improve energy absorption and the residual properties of carbon laminates when they are subjected to low velocity impact event. Two different bioinspired laminates were manufactured following a double helicoidal approach and a rotational one and were subjected to a complete test campaign including low velocity impact loading and compared to a traditional quasi-isotropic panel. Fractography analysis via X-Ray tomography was used to understand the mechanical behaviour of the different laminates and the residual properties were evaluated via Compression After Impact (CAI) tests. Results confirmed that the biological twisted structures can be replicated into traditional layered composites and are able to enhance the out-of-plane properties without a dangerous degradation of the in-plane properties.
Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats (2004)

Sequestration of adenovirus serotype 5 (Ad5) in liver restricts its use for gene delivery to other target sites in vivo. To date, no studies have systematically assessed the impact of genetic capsid modifications on in vivo tropism in rats, an important preclinical model for many disease types. We evaluated a panel of Ad5 vectors with capsid mutations or pseudotyped with the short fiber from serotype 41 (Ad41s) for infectivity in Wistar Kyoto rats in vitro and systemically in vivo. In vitro studies demonstrated that both coxsackie and adenovirus receptor (CAR) and heparan sulfate proteoglycan (HSPG) binding were predominant predictors of Ad5 tropism. In vivo, neither CAR nor integrin mutations alone affected liver transduction. The HSPG-binding mutation alone moderately reduced rat liver transgene levels by 2-fold (P < 0.05). This was further substantially decreased by additional mutation of CAR binding (95-fold). Combining CAR and integrin mutations reduced transgene levels by >99% (509-fold, P < 0.01), an effect not observed in parallel experiments in mice and highly variable when studied further in an additional two strains of rat. Ad41s mediated very low liver transduction (58-fold lower than AdCTL). Moreover, CAR-binding mutants (KO1-containing) or pseudotyping 41s eliminated hemagglutination of rat and human red blood cells in vitro. This highlights some important potential species and strain differences dictating Ad5 tropism in vivo and identifies vectors that are substantially detargeted from rat liver in vivo.
Options for the Management of Mucosal Candidiasis in Patients with AIDS and HIV Infection (1999)

Oropharyngeal candidiasis may be the first manifestation of human immunodeficiency viral (HIV) infection, and more than 90% of patients with the acquired immunodeficiency syndrome (AIDS) develop the disease. Although numerous antifungal agents are available, azoles, both topical (clotrimazole) and systemic (fluconazole, itraconazole), have largely replaced older topical antifungals (gentian violet, nystatin) in the management of the disease in these patients. A concern in these patients is clinical relapse, which appears to be dependent on degree of immunosuppression and is more common with clotrimazole and ketoconazole than with fluconazole or itraconazole. Candida esophagitis is also of concern, since it occurs in more than 10% of patients with AIDS. Fluconazole is an integral part of management. A cyclodextrin oral solution formulation of itraconazole has similar clinical response rates as fluconazole and is an effective alternative. In patients with fluconazole-resistant mucocutaneous candidiasis, treatment options include itraconazole and amphotericin B oral suspension and parenteral preparation.
Delayed hypersensitivity in mast-cell-deficient mice. (1983)

The ability of mast cell-deficient Wf/Wf and W/Wv mice to produced delayed hypersensitivity responses was examined. The W/Wv mice did not have detectable mast cells and could not produce IgE-mediated passive cutaneous anaphylaxis. Mice of both genotypes produced large delayed hypersensitivity responses to the contact sensitizers oxazolone and picryl chloride. The responses were indistinguishable from responses of control mice when challenged with optimal or suboptimal doses of antigen. Delayed hypersensitivity could be transferred into Wf/Wf mice by an antigen-specific T cell line, and the proliferative responses in the lymph nodes of these mice after, painting with sensitizer, were normal.
Plug-and-Patch (2019)

The public charging infrastructure is one of the key factors defining the adoption of Electric Vehicles (EVs), especially for drivers of conventional cars. Yet, building up a large-scale charging network is expensive, and, due to current low demand, its operation does not generate profitability for the providers. Business models involving additional services offered at Charge Points (CPs), so-called Value Added Services (VASs), may strengthen incentives to invest into public charging and its security.
Children as designers of web portals (2003)

Abstract This paper describes and discusses the process undertaken by a design team comprising both elementary school students and researchers to design a web portal intended for use by children. The team of eight grade‐six students and three researchers met twice per week over 12 sessions to design a low‐tech prototype. The approach adopted by the team was based upon several design theories related to usability studies: contextual inquiry, participatory design and cooperative inquiry. The advantages of such an inter‐generational approach to portal design are presented as well as some of its problems.
Bilateral LSTM: A Two-Dimensional Long Short-Term Memory Model With Multiply Memory Units for Short-Term Cycle Time Forecasting in Re-entrant Manufacturing Systems (2017)

Forecasting short-term cycle time (CT) of wafer lots is crucial for production planning and control in the wafer manufacturing. A novel recurrent neural network called “bilateral long short-term memory (bilateral LSTM)” is proposed to model a short-term cycle time forecasting (CTF) of each re-entrant period of a wafer lot. First, a two-dimensional (2-D) architecture is designed to transmit the wafer and layer correlations by using wafer and layer connections. Subsequently, aiming to store various error signals caused by the diverse CT data, a multiply memory structure is presented to extend the capacity of constant error carousel (CEC) in the LSTM model. The experiment results indicate that the proposed model outperforms conventional models in the accuracy and stability for the short-term CTF. Further comparative experiments reveal that the 2-D architecture can enhance the prediction accuracy and the multi-CEC structure can improve the forecasting stability for the short-term CTF of wafer lots.
An Integrated Model for Organization—Public Relational Outcomes, Organizational Reputation, and Their Antecedents (2007)

This study is to test a theoretical model regarding the effect of organization—public relationships on organizational reputation. Grounded in multidisciplinary literature, this study proposed that organization—public relational outcomes are hypothesized to influence organizational reputation, considering the exogenous influences of communication behaviors, experience, and familiarity that the research participants hold of the organizations studied. The proposed model illustrated tenable data-model fits, and most of the hypotheses were statistically supported. The key finding of the research includes that, across all organizations studied, organization—public relational outcomes were associated positively with favorable reputation of the organizations studied. Limitations and suggestions for the future research were discussed.
Tracking method of optical tape recorder using acousto-optic scanning (1991)

The tracking method of an optical tape recorder using an Acousto-Optic deflector for scanning is presented. Tracking is performed without a mechanical actuator.
Formation of high-T(c) superconducting films by organometallic chemical vapor deposition (1989)

This invention relates to a method of forming high Tc superconducting films by organometallic chemical vapor deposition. More specifically, this invention relates to a method of forming superconducting films on a semiconductor surface by chemical vapor deposition of volatile organometallic compounds of the rare earth and alkaline earth elements, and copper.
Microsatellite Marker Analysis as a Typing System for <i>Candida glabrata</i> (2005)

Candida glabrata is one of the most important causes of nosocomial fungal infection. We investigated, using a multiplex PCR, three polymorphic microsatellite markers, RPM2, MTI, and ERG3, in order to obtain a rapid genotyping method for C. glabrata. One set of primers was designed for each locus, and one primer of each set was dye labeled to read PCR signals using an automatic sequencer. Eight reference strains including other Candida species and 138 independent C. glabrata clinical isolates were tested. The clinical isolates were collected from different anatomical sites of adult patients either hospitalized in different wards of two different hospitals or not hospitalized. Since C. glabrata is haploid, one single PCR product for each PCR set was obtained and assigned to an allele. The numbers of different alleles were 5, 7, and 15 for the RPM2, MTI, and ERG3 loci, respectively. The number of allelic associations was 21, leading to a discriminatory power of 0.84. The markers were stable after 25 subcultures, and the amplifications were specific for C. glabrata. A factorial correspondence analysis did not indicate any correlation between the 21 multilocus genotypes and the clinical data (source, sex, ward, anatomical sites). Microsatellite marker analysis is a rapid and reliable technique to investigate clinical issues concerning C. glabrata. However, its discriminatory power should be improved by testing other polymorphic microsatellite loci.
Make mine a quadruple: Strengthening the security of graphical one-time PIN authentication (2011)

Secure and reliable authentication is an essential prerequisite for many online systems, yet achieving this in a way which is acceptable to customers remains a challenge. GrIDsure, a one-time PIN scheme using random grids and personal patterns, has been proposed as a way to overcome some of these challenges. We present an analytical study which demonstrates that GrIDsure in its current form is vulnerable to interception. To strengthen the scheme, we propose a way to fortify GrIDsure against Man-in-the-Middle attacks through (i) an additional secret transmitted out-of-band and (ii) multiple patterns. Since the need to recall multiple patterns increases user workload, we evaluated user performance with multiple captures with 26 participants making 15 authentication attempts each over a 3-week period. In contrast with other research into the use of multiple graphical passwords, we find no significant difference in the usability of GrIDsure with single and with multiple patterns.
Changes in plasma factor VIII complex and serum lipid profile during atherogenesis in cynomolgus monkeys. (1990)

If endothelial injury plays a prominent role in early atherogenesis, the plasma levels of von Willebrand factor (VWF), which is made within and normally released from endothelial cells, might be expected to rise as a marker of the cellular damage. To evaluate this hypothesis, we measured plasma VWF (as VIIIR:Ag), factor VIII:C, and serum lipids serially up to 37 weeks in 29 adult male cynomolgus monkeys on an atherogenic diet. Factor VIII:C peaked at 113% above baseline by week 10 (p less than 0.0001), then fell and remained 53% below baseline (p less than 0.04) during weeks 20 to 37. However, the overall rise in VWF was not significant. In contrast, serum cholesterol continued to rise after week 21. Serum phospholipids (PL), triglycerides (TG), and free fatty acids (FFA) showed a temporal pattern similar to VIII:C. Significant positive correlations with VIII:C were noted for PL (r = 0.59, p = 0.0001) and TG (r = 0.36, p = 0.0096). At autopsy, small to moderately advanced atherosclerotic lesions were distributed throughout the aortas of the majority of the animals. We conclude that changes in plasma VIIIR:Ag do not correlate with atherogenesis in this model. However, the similar course of VIII:C, TG, and PL suggests that these substances may be involved and perhaps interrelated early in atherogenesis.
Beryllium (2009)

Beryllium environmental analysis and monitoring , Beryllium environmental analysis and monitoring , کتابخانه دیجیتال جندی شاپور اهواز
Ectoenzymatic activity and bacterial dynamics along a trophic gradient in the Caribbean Sea (1993)

Bacterial biomass, potential bacterial production and ectoenzymatic activity were measured at 4 stations along a trophic gradient at the Atlantic Barrier Reef off Belize (Central America). We investigated the changes in the trophic status of this system, which we hypothesized would also lead to changes in the bacterial community. The bacterial community of the oligotrophic station was characterized by low biomass (mean 7.2 pg C 1-') and low potential production rates (mean 9.2 pg C l-Id-') as determined by seawater cultures whereas at the most eutrophic station bacterial biomass (mean 18.6 pg C I-') as well as potential bacterial production (mean 15.5 pg C I-' d-l) was significantly higher. Oligotrophic bacteria exhibit high potential turnover rates (1.5 d-l). Ectoenzymatic activity measurements with fluorogenic-substrate analogs showed distinct differences in the expression of certain enzymes at different trophic conditions. aand P-D-glucosidase activity declined from eutrophic to oligotrophic in both per volume and per cell while leucine-aminopeptidase activity per cell was inversely correlated with the trophic status of the environment. Differences in ectoenzymatic activity are indicated by differences in both v,,,,, and K, . K,,, values of leucine-aminopeptidase clearly reflect the trophic situation. Substrate affinity was found to be higher in oligotrophic waters by 2 orders of magnitude as compared to eutrophic environments. Potential activity (v,,,,) of the extracellular enzymes tested was found to be correlated to potential bacterial production and bacterial biomass.
Laser wavelength dependent properties of YBa2Cu3O7−δ thin films deposited by laser ablation (1989)

YBa2Cu3O7−δ thin films were deposited onto (100) SrTiO3 substrates using 1064, 532, 355, 248, and 193 nm laser ablation. Transport measurements show lower normal-state resistivities and higher critical currents in films deposited by the shorter wavelength lasers. The surface morphology of the films was rough with large particulates when the 1064 nm laser was used whereas much smoother surfaces with fewer and smaller particulates were obtained with the UV lasers. It is suggested that the better film quality obtained when the UV lasers are used is due to a small absorption depth of the UV photons in the ceramic target and to higher absorption by the ablated fragments. This leads to smaller ablated species and further fragmentation in the hotter plume and, therefore, to smoother and denser films.
Cystine and Theanine Supplementation Restores High-Intensity Resistance Exercise-Induced Attenuation of Natural Killer Cell Activity in Well-Trained Men (2010)

We investigated the effects of supplementation with cystine, a dipeptide of cysteine, and theanine (CT), a precursor of glutamate, on immune variables during high-intensity resistance exercise. Cysteine and glutamate are involved in the formation of glutathione, which modulates the activity of natural killer (NK) cells. In this double-blinded clinical trial, 15 well-trained men (aged 22.8 +/- 4.0 years) were divided into 2 groups: placebo (n = 7) and CT (n = 8). The placebo group was administered a powder containing cellulose (950 mg) and glutamate (30 mg), whereas the CT group was administered a powder containing cystine (700 mg) and theanine (280 mg), once daily for 2 weeks. The subjects trained according to their normal schedule (3 times per week) in the first week and trained at double the frequency (6 times per week) in the second week. Concentrations of immunoglobulin (Ig)M, interleukin (IL)-6, IL-8, and salivary IgA and the leukocyte count did not change significantly in either group. There was a significant decrease (p < or = 0.05) in the NK cell activity (NKCA) in the placebo group after the second week compared with that in the CT group (placebo: 69.2 +/- 16.1% vs. CT: 101.7 +/- 38.7%). Phytohemagglutinin-induced lymphocyte blastoid transformation did not change significantly in either group. These results suggest that NKCA is not affected in a normal training schedule with or without CT supplementation. However, high-intensity and high-frequency resistance exercises cause attenuation of NKCA, which CT supplementation appears to restore. Therefore, in practical application, CT supplementation would be useful for athletes to restore the attenuation of NKCA during high-intensity and high-frequency training.