gebhart/patrepeval huggingface dataset:
Human ciliary process adrenergic receptor: pharmacological characterization. (1981)

To better understand the nature of interaction of various amines with adrenergic receptors in te human ciliary process, beta-adrenergic-stimulated adenylate cyclase activity was characterized in broken cell preparations of this tissue from donor eyes. Among various agonists, isoproterenol was the most potent activator of enzyme activity (Ka = 3.4 x 10(-7)M), followed in order by epinephrine (Ka = 2.7 x 10(-6)M), norepinephrine (Ka = 2.1 x 10(-5)M), and phenylephrine (Ka greater than 10(-4)M). Isoproterenol-stimulated enzyme activity was blocked by timolol (Ki = 3.4 x 10(-9)M), IPS 339 (Ki = 4.4 x 10(-9)M), H35/25 (Ki = 6.9 x 10(-7)M), and atenolol (Ki = 1.4 x 10(-5)M). These pharmacological characteristics indicate that the human ciliary processes contain a predominance of beta2-adrenergic receptors. The findings are relevant to physiological studies of aqueous humor secretion and to the potential development of adrenergic agents with greater specificity for the beta-adrenergic receptor.
Maintenance management of wind power systems Cost effect analysis of condition monitoring systems (2006)

The wind power industry has experienced a large growth the past years. The growth mainly focus on a growing market, better economical conditions for wind power because of political decisions and the development of large wind turbines and offshore farms. A goal is to increase reliability for turbines. The topic is even more important for offshore farms where service is difficult and expensive. The answer for the wind power industry, for better maintenance management and increased reliability, could be Condition Monitoring Systems (CMS). Such systems are commonly used in other industries. They continuously monitor the performance of the wind turbine parts e.g. generator, gearbox and transformer, and help determine the best time for a specific maintenance work. How these systems could support the wind power user is investigated in this report. The further step could be to implement CMS as a part of Reliability Centered Maintenance (RCM).RCM is a structured approach that focus on reliability aspects when determining maintenance plans, that is to find a balance between preventive- and corrective maintenance. Preventive maintenance is maintenance carried out before failures occur and corrective maintenance is maintenance carried out after failures occur. Condition Monitoring can consist of e.g. vibration analysis and oil analysis. In these two different analyses there are several methods that can be used. The components that are of interest of condition monitoring are the gearbox, generator and the main shaft. The component of most interest, and that it has been shown is a critical component due to its impact on system availability, is the gearbox. Life Cycle Cost (LCC) analyses have been made to calculate if it is profitable to implement CMS. The total cost, LCC including additional costs for implementing CMS, is compared for different alternative maintenance strategies. For a single turbine onshore versus an average turbine offshore in three strategies, and for a farm offshore where maintenance is planned using CMS in three strategies. The LCC without costs for CMS is called the basic case. The first three strategies studied for the separate turbine onshore gave the following results when a CMS cost is added to the basic case; to compensate for the additional cost the preventive maintenance has to be decreased by 23 %. To compensate for the additional cost the preventive and corrective maintenance together have to be decreased by 3,5 %. The same results for the farm offshore, where an average turbine was observed, were 4,5 % and 2,5 % respectively. Decreased corrective maintenance is needed to motivate CMS, at least for the turbine onshore. The following three strategies studied for the farm offshore gave the following results: a change from corrective maintenance to preventive maintenance with 47 % would be enough to make CMS profitable. The availability would not have to be increased with more than 0,43 % to get a reduction in cost for production loss that would cover the cost for CMS.
Strongly nonlinear wave dynamics in a chain of polymer coated beads (2006)

Strongly nonlinear phononic crystals were assembled from a chain of Parylene-C coated steel spheres in a polytetrafluoroethylene holder. This system exhibits strongly nonlinear properties and extends the range of materials supporting sonic-vacuum-type behavior. The combination of a high density core and a soft (low elastic modulus) coating ensures a relatively low velocity of wave propagation. The bead contact interaction caused by the deformation of the Parylene coating can be described by classical nonlinear elastic Hertz theory with an effective value of the elastic modulus equal to 15 GPa for the contact interaction. Strongly nonlinear solitary waves excited by impacts were investigated experimentally and compared to chains composed of uniform steel beads. Fracture of the polymer coating was detected under relatively large pulse amplitude.
Trifluoromethanesulfonyl azide. Its reaction with alkyl amines to form alkyl azides (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrifluoromethanesulfonyl azide. Its reaction with alkyl amines to form alkyl azidesC. J. Cavender and V. J. Shiner Jr.Cite this: J. Org. Chem. 1972, 37, 22, 3567–3569Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/jo00795a052https://doi.org/10.1021/jo00795a052research-articleACS PublicationsRequest reuse permissionsArticle Views5251Altmetric-Citations131LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hierarchical extraction of 3D interconnect capacitances in large regular VLSI structures (1993)

For submicron integrated circuits, 3D numerical techniques are required to accurately compute the values of the interconnect capacitances. In this paper, we describe an hierarchical capacitance extraction method that efficiently extracts 3D interconnect capacitances of large regular layout structures such as RAMs and array multipliers. The method is based on a 3D capacitance extraction method that uses a boundary-element technique and approximate matrix inversion to efficiently compute 3D interconnect capacitances for flat layout descriptions. The latter method has a computational complexity O(Z), where Z is the size of the layout. In the worst case, the hierarchical extraction method has computational complexity O(B+U), where B is the total size of the boundary area between all circuit parts in which the circuit is decomposed, and U is the total size of the parts of the circuit that are unique. The method has been implemented in the layout-to-circuit extractor SPACE that uses as input a hierarchical layout description of the circuit. It produces as output a netlist containing transistors, resistances, ground capacitances, and coupling capacitances between conductor parts that are near to each other.
Nemos: Working towards the &#x201C;social&#x201D;mobile phone (2009)

NEMOS is the Mobile Social Service Platform that has developed out of the ExpeShare project to cover the distribution and sharing of social content. Within this project the meta-community concept was made it up and then implemented in order for the users to exchange their social content in a smoothly way from their mobile. NEMOS is both a client application and a server platform all together integrated within the ExpeShare platform which purpose is to enable virtual communities to share media experiences in their personal devices easily, legally and securely.
Abstract 2692: An ongoing Phase II trial of an adenovirus/PSA vaccine for prostate cancer (2012)

Abstract Introduction and Objectives: Our Phase I adenovirus/PSA vaccine trial has proved that this vaccine is safe. We are conducting a Phase II clinical trial with two separate protocols for patients with recurrent or hormone refractory prostate cancer assessing toxicity, immune responses, and changes in PSA levels. Methods: In Protocol #1 men with recurrent prostate cancer following definitive initial treatment for their disease were placed in one of two arms: Arm A; men receive the vaccine alone at days 0, 30, and 60; Arm B; men receive the vaccine 14 days after the initiation of androgen deprivation therapy (ADT). In Protocol #2 men with hormone refractory disease receive the vaccine alone using the same 3 injection schedule. Each injection consists of 108 pfu of the Ad/PSA vaccine suspended in a collagen matrix. All patients return at regular intervals for physical, chemical, radiologic, and immunologic evaluations. Results: To date forty four patients have been enrolled and have been followed a median of 12 months. The patients have a median age of 71.3 years, and median enrollment PSA levels of 0.62 ng/ml in Protocol #1 and 5.45 ng/ml in Protocol #2. In our preliminary results at this early stage of the trial, 100% of the patients in Protocol #1 and 67% of the patients in Protocol #2 demonstrated anti-PSA T cell responses above preinjection levels. Sixty four percent of the patients demonstrated an increase in PSA doubling time (PSADT). Conclusions: In an attempt to follow up on the success of our Phase I clinical trial of the Ad/PSA vaccine we have initiated a Phase II trial to investigate the therapeutic efficacy of the vaccine in men with recurrent prostate cancer, either following definitive therapy prior to other treatments or hormone refractory. Early results from the first four four patients demonstrate the induction of anti-PSA T cells responses in a high percentage of the vaccinated patients and increase in PSADT in more than half of the patients. No serious vaccine-related toxicities have been identified in the patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2692. doi:1538-7445.AM2012-2692
Centroid-Based Document Classification Algorithms: Analysis & Experimental Results (2000)

Abstract : In recent years we have seen a tremendous growth in the volume of text documents available on the Internet, digital libraries, news sources, and company-wide intranets. Automatic text categorization, which is the task of assigning text documents to pre-specified classes (topics or themes) of documents, is an important task that can help both in organizing as well as in finding information on these huge resources. Text categorization presents unique challenges due to the large number of attributes present in the data set, large number of training samples, and attribute dependencies. In this paper we focus on a simple linear-time centroid-based document classification algorithm, that despite its simplicity and robust performance, has not been extensively studied and analyzed. Our extensive experiments show that this centroid-based classifier consistently and substantially outperforms other algorithms such as Naive Bayesian, k-nearest-neighbors, and C4.5, on a wide range of datasets. Our analysis shows that the similarity measure used by the centroid-based scheme allows it to classify a new document based on how closely its behavior matches the behavior of the documents belonging to different classes, as measured by the average similarity between the documents. This matching allows it to dynamically adjust for classes with different densities. Furthermore, our analysis shows that the similarity measure of the centroid-based scheme accounts for dependencies between the terms in the different classes. We believe that this feature is the reason why it consistently outperforms other classifiers that cannot take these dependencies into account.
Calculating the effective capacitance for the RC interconnect in VDSM technologies (2003)

In this paper, we present a new technique for calculating an effective capacitance of an RC interconnect line in very deep submicron design technologies. The calculation scheme guarantees that the effective capacitance model simultaneously matches both the 50% propagation delay and the 0-to-0.8Vdd output transition behavior of a standard cell driving an RC interconnect. Experimental results show that the new technique exhibits high accuracy (less than 5% error) and high efficiency (converges in two or at most three iterations). The paper also includes extensions to handle complex cells as drivers of the RC interconnect.
A 30.5 dBm 48% PAE CMOS Class-E PA With Integrated Balun for RF Applications (2008)

Integration of the power amplifier together with signal processing in a transmitter is still missing in demanding RF commercial products. Issues preventing PA integration include LO pulling phenomena, thermal dissipation, and power efficiency. In this work we investigate high efficiency watt range Class-E PAs and integrated baluns. In particular, insights in the design of a fully differential cascode topology for high efficiency and reliable operation are provided and a narrowband lumped element balun, employing minimum number of integrated inductors for minimum power loss, is introduced. Two versions have been manufactured using a 0.13 mum CMOS technology. The first comprises the driver, and a differential PA connected to an external low-loss commercial balun. Experiments prove 31 dBm delivered output power, with 58% PAE and 67% drain efficiency, at 1.7 GHz. The second version adopts the same driver and PA and also integrates the balun. Experiments prove 30.5 dBm delivered output power, with 48% PAE and 55% drain efficiency, at 1.6 GHz.
[The lactate oxidase activity of Aerococcus viridans cultures]. (1990)

The oxidase activity of Aerococcus viridans is a result of the functioning of aerobic NAD-independent lactate dehydrogenase. Two fractions of flavin-containing protein which oxidize D- and L-isomers of lactic acid are revealed during the enzymic complex electrophoresis in PAAG. The enzymic complex and eluates of both fractions possess the antagonistic activity relative to 27 test-cultures of bacteria.
Stroke segmentation as a basis for structural matching of Chinese characters (2002)

A new stroke segmentation technique is reported. It is based on two essential operations applied to a given character: grouping adjacent segments into blade-like objects according to change of width as measured from global directions, and transforming those objects according to width variation as measured from intrinsic orientations. This technique proves to be effective in dividing Chinese characters into overlapping and non-overlapping components. Strokes are then restored, with the help of templates, by linking certain non-overlapping components terminating at the same overlapping areas. The resulting framework also lays down a basis for the structural matching of Chinese characters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effect of Low Dose Dexmedetomidine on Emergence Delirium and Recovery Profile following Sevoflurane Induction in Pediatric Cataract Surgeries (2015)

This randomized trial was conducted to assess the efficacy and recovery profile of low dose intravenous dexmedetomidine in prevention of post-sevoflurane emergence delirium in children undergoing cataract surgery. Sixty-three children aged 1–6 years were included. Anesthesia was induced with sevoflurane and airway was maintained with LMA. They were randomized to group D 0.15 (received intravenous dexmedetomidine 0.15 μ g/kg), group D 0.3 (received dexmedetomidine 0.3 μ g/kg), or group NS (received normal saline). The incidence of emergence delirium, intraoperative haemodynamic variables, Aldrete scoring, pain scoring, rescue medication, and discharge time were recorded. Emergence delirium was significantly reduced in dexmedetomidine treated groups with incidence being 10% in group D 0.15, none in group D 0.3, and 35% in the NS group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.002</mml:mn></mml:math>). Significantly lower PAED scores were observed in D 0.15 and D 0.3 group compared to the NS group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.004</mml:mn></mml:math>). Discharge time was significantly prolonged in the NS group compared to D 0.15 and D 0.3 (45.1 min ± 4.4 versus 36.8 min ± 3.8 versus 34.4 min ± 4.6), <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.02</mml:mn></mml:math>. Intravenous dexmedetomidine in low doses (0.3 and 0.15 μ g/kg) was found to be effective in reducing emergence delirium in children undergoing unilateral cataract surgery.
Familial Aggregation of Parkinson's Disease in Iceland (2000)

Late-onset Parkinson's disease has a genetic component as well as an environmental component.
Antioxidants and cancer, part 3: quercetin. (2000)

Quercetin is a flavonoid molecule ubiquitous in nature. A number of its actions make it a potential anti-cancer agent, including cell cycle regulation, interaction with type II estrogen binding sites, and tyrosine kinase inhibition. Quercetin appears to be associated with little toxicity when administered orally or intravenously. Much in vitro and some preliminary animal and human data indicate quercetin inhibits tumor growth. More research is needed to elucidate the absorption of oral doses and the magnitude of the anti-cancer effect.
The identification and quantification of some non‐volatile oxidation products of fatty acids developed during prolonged storage of wheat flour (1980)

Abstract Three white bread flours, stored in good conditions for 5 years have been investigated for the presence of non‐volatile oxidation products of linoleic acid. Two products have been identified and their rate of accumulation with time of storage determined.
Synthesis of Macrocyclic Peptide Analogues of Proteasome Inhibitor TMC-95A (2003)

The synthesis of three constrained macrocyclic peptide analogues 1 of TMC-95A as potential proteasome inhibitors is described. The key step involves a Ni(0)-mediated macrocyclization of tripeptides 2 bearing halogenated aromatic side chains for the formation of the biaryl junction. In addition, an enantioselective preparation of l-7-bromotryptophan methyl ester 3 using a Corey-O'Donnell alkylation of the glycine benzophenone imine was achieved in good overall yield with very high ee (>85%) on a multigram scale.
Extremely High 2DEG Concentration in Selectively Doped In<sub>0.53</sub>Ga<sub>0.47</sub>As/N-In<sub>0.52</sub>Al<sub>0.48</sub>As Heterostructures Grown by MBE (1987)

Electron mobility and 2DEG concentration in MBE-grown, selectively doped In 0.53 Ga 0.47 As/N-In 0.52 Al 0.48 As heterostructures, lattice-matched to InP, were studied as a function of Si-doping concentration in N-In 0.52 Al 0.48 As. A 2DEG concentration of as high as 3.7×10 12 cm -2 (µ=22,000cm 2 /Vs at 77 K) was achieved with a Si-doping concentration of 5×10 18 cm -3 in N-In 0.52 Al 0.48 As. This N s value is the highest 2DEG concentration ever reported for selectively doped single-interface heterostructures, and is almost four times higher than that of conventional GaAs/N-AlGaAs heterostructures.
Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms (2016)

The literature research indicated that inflammation is a part of epileptogenesis. For this reason, further studies are necessary for assessing agents that will be effective in clinical use for therapeutic treatment of epileptogenesis.
Positive and negative selection of T cells in T-cellreceptor transgenic mice expressing a bcl-2 transgene. (1994)

To explore the role of bcl-2 in T-cell development, a bcl-2 transgene was introduced into mice expressing a T-cell receptor (TCR) transgene encoding reactivity for the mouse male antigen HY presented by the H-2Db class I antigen of the major histocompatibility complex (MHC). Normal thymic development is contingent on the ability of immature thymocytes to interact with self-MHC molecules presented by thymic stroma (positive selection). Thus, thymocyte numbers are low in female anti-HY TCR transgenic mice with a nonselecting (H-2Dd) background. Expression of bcl-2 inhibited the death of nonselectable thymocytes since, strikingly, female H-2Dd bcl-2/TCR transgenic mice developed normal numbers of CD4+CD8+ thymocytes, although these did not mature further into functional T cells. Hence, TCR-MHC interaction may induce positive selection through two signals, one which saves cells from death by increasing Bcl-2 synthesis and another which promotes maturation. Male H-2Db anti-HY TCR transgenic mice normally have a very small thymus, due to deletion of the self-reactive T cells. Expression of bcl-2 reduced the efficiency of deletion, since bcl-2/TCR transgenic male mice accumulated 4- to 6-fold more thymocytes than did TCR transgenic male littermates. Anti-HY TCR-expressing cells were also more numerous in the peripheral lymphoid tissues, but these cells expressed abnormally low levels of CD8 co-receptor and were not responsive to the HY antigen. Thus, although bcl-2 expression hampers the deletion of immature self-reactive cells in the thymus, self-tolerance is maintained.
A robotic wayfinding system for the visually impaired (2004)

We present an emerging indoor assisted navigation system for the visually impaired. The core of the system is a mobile robotic base with a sensor suite mounted on it. The sensor suite consists of an RFID reader and a laser range finder. Small passive RFID sensors are manually inserted in the environment. We describe how the system was deployed in two indoor environments and evaluated by visually impaired participants in a series of pilot experiments.