gebhart/patrepeval huggingface dataset:
SAR Reduction Using Integration of PIFA and AMC Structure for Pentaband Mobile Terminals (2017)

In this paper, a capacitive grating artificial magnetic conductor (AMC) is presented to reduce the specific absorption rate (SAR) in pentaband mobile terminals. The AMC structure is implemented using a dielectric film with the printed arrays of the metal strips placed at the top and the bottom of the dielectric. It is difficult to design the AMC structure to operate at low (824~960 MHz) and high bands (1710~2170 MHz) simultaneously, because of the limited space available for the antenna. Hence, we have designed the capacitive grating AMC to operate at a high band. Then, we attached a PIFA to the AMC structure to cover low and high bands. As the AMC structure is operated as a perfect electric conductor (PEC) in low band, the radiating branches of the PIFA for the low and high bands should be located on the non-AMC and the AMC structures, respectively. Even though the AMC structure is operated at a high band, the effect against the head could be reduced in the pentaband due to the spreading effect of the electromagnetic (EM) field at lower bands. From measured results, the 1 g SAR in the case of the AMC antenna is significantly lower than that in the case where only the PIFA is present in the pentaband.
Mutagenesis of the dehydratase active site in the erythromycin-producing polyketide synthase (1993)

Conference Article| February 01 1993 Mutagenesis of the dehydratase active site in the erythromycin-producing polyketide synthase DEBRA J. BEVITT; DEBRA J. BEVITT 1Department of Biochemistry, University of Cambridge, Tennis Court Rd., Cambridge CB2 1QW, U.K. Search for other works by this author on: This Site PubMed Google Scholar J. STAUNTON; J. STAUNTON *University Chemical Laboratory, Lensfield Rd., CB2 1EW Cambridge, U.K. Search for other works by this author on: This Site PubMed Google Scholar PETER F. LEADLAY PETER F. LEADLAY 1Department of Biochemistry, University of Cambridge, Tennis Court Rd., Cambridge CB2 1QW, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (1): 30S. https://doi.org/10.1042/bst021030s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation DEBRA J. BEVITT, J. STAUNTON, PETER F. LEADLAY; Mutagenesis of the dehydratase active site in the erythromycin-producing polyketide synthase. Biochem Soc Trans 1 February 1993; 21 (1): 30S. doi: https://doi.org/10.1042/bst021030s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
Platform degrader analysis for the design and development of Vehicle Health Management Systems (2008)

The US Armypsilas Heavy Brigade Combat Team (HBCT) is investigating the implementation of Vehicle Health Management Systems across its fleet of platforms. A vehicle degrader analysis was conducted to determine where the application of vehicle health management systems (VHMS) could potentially have the greatest impact on increasing maintainer effectiveness and operational availability. The analysis was conducted for M1 Abrams tanks and M2/M3 Bradley Fighting Vehicles using data from three sources: (1) multi-year statistical data on repairs, operating and support costs, and logistics data, (2) interviews with maintainers, service representatives and operators, and (3) questionnaires completed by the platform OEMpsilas. The paper will describe how these alternative data and information sources were used when ideal data and information sources were not available. The statistical data provided an indication of vehicle consumable and repairable cost drivers, part replacement quantity and some indication of component failure isolation for vehicle systems. The interviews with vehicle maintainers, field service representatives and operators provided insight into platform reliability, maintainability and human factors issues. The maintainability, reliability and diagnostic coverage information from the OEMpsilas, provided information about mission criticality and general diagnostic capability for specific vehicle sub-systems and components. The results of the degrader analysis include a list of components and sub-systems that contribute most to maintainability, reliability and vehicle operational availability issues. The degrader results, were used to develop the conceptual design of the optimum application of embedded vehicle diagnostics and prognostics for more effective and efficient HCBT platform maintenance, logistic support and platform life cycle management.
Insolvency law: bankruptcy and liquidation (1995)

John Smith has been employed as a garage mechanic for about ten years with a large motor company in Exeter. He has always wanted to go into business and an opportunity presents itself when a small garage with showroom and petrol pumps becomes available on the outskirts of Exeter. John sets up business operating under the name of Merton (Motors). He has no real experience in running his own business and after about a year of trading he finds that he is quite heavily in debt. With trade particularly poor in all aspects of his business, that is in petrol sales, servicing and second-hand cars, he cannot see any prospect of settling the following outstanding debts: (1) £ 1 059 to the local authority for business rates (2) £ 4 900 to Associated Motors for spares (3) £25 500 to Quality Cars Ltd for three second-hand cars (4) £ 9 000 to United Motor Equipment Ltd for garage equipment, tools, testing gear, etc. (5) £15 900 to a leading petrol company for petrol (6) £ 360 to Allcock & Sons Ltd, a local builder, for building repairs
Nanostructured Nickel/Ruthenium/Ruthenium‐Oxide Supercapacitor Displaying Exceptional High Frequency Response (2019)

Abstract The lower performance of pseudocapacitive supercapacitors in high‐frequency applications such as alternating current (AC) line filtering has been ascribed to presumed slow kinetics of redox processes compared to ion diffusion in electric double layer capacitors. A nickel‐deposited ruthenium/ruthenium‐oxide symmetric supercapacitor exhibiting remarkable electrochemical properties, particularly very high frequency response (>1 kHz) is developed. The electrodes are prepared via a simple process consisting of electrochemical reduction of ruthenium chloride on commercially available nickel foil as the current collector. A symmetric supercapacitor comprising nickel/ruthenium/ruthenium‐oxide electrodes and a polystyrene‐based thin spacer exhibits particularly fast scan rates, high power density of 1500 mW cm −2 (88 kW cm −3 ) with a maximum energy density of 0.58 µWh cm −2 (34 mWh cm −3 ), and excellent capacitance retention. Notably, supercapacitors prepared by the same synthetic method albeit using conventional gold substrate instead of nickel exhibit significantly lower frequency response. The exceptional electrochemical properties of the nickel/ruthenium/ruthenium‐oxide supercapacitor and simple electrode synthesis point to promising applicability in AC line filtering and power conditioning. In a broader context, this work demonstrates that, contrary to the widely held presumption, the kinetics of redox reactions at the active layers of pseudocapacitors may not be the primary barriers to high‐frequency applications.
Human Lymphocyte Response to Phytomitogens <i>in Vitro</i>: Normal, Agammaglobulinemic and Paraproteinemic Individuals (1969)

Abstract Studies of the time course of thymidine incorporation during stimulation of lymphocytes from normal individuals with four plant mitogens over a 10-day period demonstrate several differences in response profiles. Whereas the peak responses for cultures stimulated with phytohemagglutinin (PHA), wax bean glycoprotein and concanavalin A (Con A) occurred at 3 or 5 days, the lower peak response to pokeweed mitogen (PWM) was observed at 5 or 7 days. Cultures stimulated with PHA, wax bean glycoprotein and PWM continued to show significant thymidine incorporation at 7 and 10 days, although the response to Con A had returned to baseline after 7 days. Lymphocytes from eight adult “acquired” agammaglobulinemic patients and their four available parents had a diminished thymidine incorporation in 3-day cultures using each of the four mitogens (p &lt; 0.001). A late response was observed with PHA or wax bean stimulation at 5 to 7 days, comparable to controls at 3 days. With Con A, lymphocytes from both the “acquired” agammaglobulinemic patients and their parents had a diminished incorporation throughout the 10-day period (p &lt; 0.001). Stimulation with PWM distinguished the lymphocytes of the patients from their heterozygous parents; at 5 to 7 days the parents had a peak comparable to controls, whereas the “acquired” agammaglobulinemics had a diminished peak (p &lt; 0.001) at 10 days. Lymphocytes from patients with multiple myeloma and Waldenström's macroglobulinemia had diminished thymidine incorporation in response to Con A during a 10-day incubation period. These patients had normal or late responses comparable in magnitude to controls with PHA, wax bean glycoprotein and PWM. These observations suggest that plant mitogens have selective and specific actions on lymphocyte subpopulations. Differences in the time course and magnitude of lymphocyte response to plant mitogens may reflect different circulating subpopulations of cells or alterations in the total number of cells responsive to mitogen. Detailed time studies using several mitogenic agents represent a possible approach to the assessment of lymphocyte function in immunologic diseases.
How Toxic Are Toxic Chemicals in Soil? (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHow Toxic Are Toxic Chemicals in Soil?Martin. AlexanderCite this: Environ. Sci. Technol. 1995, 29, 11, 2713–2717Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/es00011a003https://doi.org/10.1021/es00011a003research-articleACS PublicationsRequest reuse permissionsArticle Views1665Altmetric-Citations515LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Advances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives (2017)

Zika virus (ZIKV) remained largely quiescent for nearly six decades after its first appearance in 1947. ZIKV reappeared after 2007, resulting in a declaration of an international "public health emergency" in 2016 by the World Health Organization (WHO). Until this time, ZIKV was considered to induce only mild illness, but it has now been established as the cause of severe clinical manifestations, including fetal anomalies, neurological problems, and autoimmune disorders. Infection during pregnancy can cause congenital brain abnormalities, including microcephaly and neurological degeneration, and in other cases, Guillain-Barré syndrome, making infections with ZIKV a substantial public health concern. Genomic and molecular investigations are underway to investigate ZIKV pathology and its recent enhanced pathogenicity, as well as to design safe and potent vaccines, drugs, and therapeutics. This review describes progress in the design and development of various anti-ZIKV therapeutics, including drugs targeting virus entry into cells and the helicase protein, nucleosides, inhibitors of NS3 protein, small molecules, methyltransferase inhibitors, interferons, repurposed drugs, drugs designed with the aid of computers, neutralizing antibodies, convalescent serum, antibodies that limit antibody-dependent enhancement, and herbal medicines. Additionally, covalent inhibitors of viral protein expression and anti-Toll-like receptor molecules are discussed. To counter ZIKV-associated disease, we need to make rapid progress in developing novel therapies that work effectually to inhibit ZIKV.
A Versatile Soft Crawling Robot with Rapid Locomotion (2019)

This article presents a versatile soft crawling robot capable of rapid and effective locomotion. The robot mainly consists of two vacuum-actuated spring actuators and two electrostatic actuators. By programming the actuation sequences of different actuators, the robot is able to achieve two basic modes of locomotion: linear motion and turning. Subsequently, we have developed analytical models to interpret the static actuation performance of the robot body, including linear and bending motions. Moreover, an empirical dynamic model is also developed to optimize the locomotion speed in terms of frequency and duty cycle of the actuation signal. Furthermore, with the help of the strong electroadhesion force and fast response of the deformable body, the soft robot achieves a turning speed of 15.09°/s, which is one of the fastest among existing soft crawling robots to the best of our knowledge. In addition to the rapid and effective locomotion, the soft crawling robot can also achieve multiple impressive functions, including obstacle navigation in confined spaces, climbing a vertical wall with a speed of 6.67 mm/s (0.049 body length/s), carrying a payload of 69 times its self-weight on a horizontal surface, crossing over a 2 cm (0.15 body length) gap, and kicking a ball.
A processor for a high-performance personal computer (1998)

Article A processor for a high-performance personal computer Share on Authors: Butler W. Lampson Xerox Research Center, 3333 Coyote Hill Road, Palo Alto, Calfornia Xerox Research Center, 3333 Coyote Hill Road, Palo Alto, CalforniaView Profile , Kenneth A. Pier Xerox Research Center, 3333 Coyote Hill Road, Palo Alto, Calfornia Xerox Research Center, 3333 Coyote Hill Road, Palo Alto, CalforniaView Profile Authors Info & Claims ISCA '98: 25 years of the international symposia on Computer architecture (selected papers)August 1998 Pages 180–194https://doi.org/10.1145/285930.285978Online:01 August 1998Publication History 0citation314DownloadsMetricsTotal Citations0Total Downloads314Last 12 Months3Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Pacinian Corpuscle in the Human Pancreas (2001)

During our systematic examination of the distribution of cytochrome P450 enzymes in the normal and diseased human pancreas, we observed a Pacinian corpuscle in a serial section of a tissue from a pancreatic cancer patient. We report the histologic and immunohistochemical patterns in this corpuscle and review the literature. The Pacinian corpuscle was situated within the pancreas of a 76-year-old woman with cancer in the head of the pancreas. We could demonstrate immunoreactivity within the corpuscle for the neurofilament protein. neuron-specific enolase, S-100 Protein, and for four cytochrome P450-isozymes. The possible function of Pacinian corpuscles in the mammalian and human pancreas is discussed.
Analysis of electromagnetic scattering from dielectric cylinders using a multifilament current model (1987)

A moment solution is presented for the problem of transverse magnetic (TM) scattering from homogeneous dielectric cylinders. The moment solution uses fictitious filamentary currents to simulate both the field scattered by the cylinder and the field inside the cylinder and in turn point-matches the continuity conditions for the tangential components of the electric and magnetic fields across the cylinder surface. The procedure is simple to execute and is general in that cylinders of arbitrary shape and complex permittivity can be handled effectively. Metallic cylinders are treated as reduced cases of the general procedure. Results are given and compared with available analytic solutions, which demonstrate the very good performance of the procedure.
Targeted mRNA degradation by complex-mediated delivery of antisense RNAs to intracellular human mitochondria (2008)

Mitochondrial dysfunction underlies a large number of acute or progressive diseases, as well as aging. However, proposed therapies for mitochondrial mutations suffer from poor transformation of mitochondria with exogenous DNA, or lack of functionality of the transferred nucleic acid within the organelle. We show that a transfer RNA import complex (RIC) from the parasitic protozoon Leishmania tropica rapidly and efficiently delivered signal-tagged antisense (STAS) RNA or DNA to mitochondria of cultured human cells. STAS-induced specific degradation of the targeted mitochondrial mRNA, with downstream effects on respiration. These results reveal the existence of a novel small RNA-mediated mRNA degradation pathway in mammalian mitochondria, and suggest that RIC-mediated delivery could be used to target therapeutic RNAs to the organelle within intact cells.
Structural Basis for Two-component System Inhibition and Pilus Sensing by the Auxiliary CpxP Protein (2011)

Bacteria are equipped with two-component systems to cope with environmental changes, and auxiliary proteins provide response to additional stimuli. The Cpx two-component system is the global modulator of cell envelope stress in gram-negative bacteria that integrates very different signals and consists of the kinase CpxA, the regulator CpxR, and the dual function auxiliary protein CpxP. CpxP both inhibits activation of CpxA and is indispensable for the quality control system of P pili that are crucial for uropathogenic Escherichia coli during kidney colonization. How these two essential biological functions of CpxP are linked is not known. Here, we report the crystal structure of CpxP at 1.45 Å resolution with two monomers being interdigitated like "left hands" forming a cap-shaped dimer. Our combined structural and functional studies suggest that CpxP inhibits the kinase CpxA through direct interaction between its concave polar surface and the negatively charged sensor domain on CpxA. Moreover, an extended hydrophobic cleft on the convex surface suggests a potent substrate recognition site for misfolded pilus subunits. Altogether, the structural details of CpxP provide a first insight how a periplasmic two-component system inhibitor blocks its cognate kinase and is released from it.
Sliding mode control for an obstacle avoidance strategy based on an harmonic potential field (2002)

This paper introduces a new integrated path control strategy (combined path planning and motion control) for autonomous systems of arbitrary dimension. A harmonic artificial potential field is used to specify admissible trajectories leading around obstacles. Using a sliding mode controller, motion is generated along the gradient lines of the potential field, avoiding collisions with the obstacles. The extremely low computational complexity of the proposed method makes it very suitable for online applications. The strategy is applied to mobile robots moving amidst known obstacles. Only the obstacle closest to the robot is considered at each time instance. The switching of the two respective gradient fields along the equi-distance line between two obstacles leads to the interesting phenomenon of an additional "spatial" sliding surface, which is examined in detail. The algorithm guarantees approaching the goal point continuously, following a reasonably short path. Numerical examples are presented to demonstrate the utility of this new strategy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17) (2013)

The Fc receptor CD16 is present on essentially all CD56(dim) peripheral blood natural killer (NK) cells. Upon recognition of antibody-coated cells it delivers a potent signal to NK cells, which eliminate targets through direct killing and cytokine production. Here we investigated the regulation of CD16 surface expression after NK cell activation. Cytokine activation and target cell stimulation led to marked decreases in CD16 expression. Activation of CD56(dim) NK cells by cross-linking CD16 with antibodies resulted in a loss of CD16 and CD62L, which correlated with increased interferon-γ production. A disintegrin and metalloprotease-17 (ADAM17) is shown to be expressed by NK cells, and its selective inhibition abrogated CD16 and CD62L shedding, and led to enhanced interferon-γ production, especially when triggering was delivered through CD16. Fc-induced production of cytokines by NK cells exposed to rituximab-coated B cell targets was also enhanced by ADAM17 inhibition. This supports an important role for targeting ADAM17 to prevent CD16 shedding and improve the efficacy of therapeutic antibodies. Our findings demonstrate that over-activation of ADAM17 in NK cells may be detrimental to their effector functions by down-regulating surface expression of CD16 and CD62L.
Knowledge transfer for high-performance quadrocopter maneuvers (2013)

Iterative Learning Control algorithms are based on the premise that “practice makes perfect”. By iteratively performing an action, repetitive errors can be learned and accounted for in subsequent iterations, in a non-causal and feedforward manner. This method has been previously implemented for a quadrocopter system, enabling the quadrocopter to learn to accurately track high-performance slalom trajectories. However, one major limitation of this system is that knowledge from previously learned trajectories is not generalized or transferred to new trajectories; these must be learned from a state of zero experience. This paper experimentally shows that the major dynamics of the Iterative Learning Control process can be captured by a linear map, trained on previously learned slalom trajectories. This map enables this prior knowledge to be used to improve the initialization of an unseen trajectory. Experimental results show that prediction based on a single prior is enough to reduce the initial tracking error for an unseen trajectory by an order of magnitude.