gebhart/patrepeval huggingface dataset:
The role of the ret proto-oncogene in human disease. (1997)

The ret proto-oncogene encodes a receptor tyrosine kinase with a cadherin-like motif in the extracellular domain. Recently, it turned out that ret is the causative gene for the development of multiple endocrine neoplasia (MEN) type 2A and type 2B and Hirschsprung's disease. MEN 2A and MEN 2B mutations represent activating changes of ret whereas Hirschsprung mutations inactivate ret. In addition, another activating change of ret was found in papillary thyroid carcinoma, particularly in those cancers which developed in children from areas contaminated by the Chernobyl accident. This review summarizes the role of ret in the development of human disease.
Wrinkled Nanoporous Gold Films with Ultrahigh Surface-Enhanced Raman Scattering Enhancement (2011)

Amplified by plasomonic nanostructured metals, Raman intensity of organic molecules and biomolecules can be dramatically improved, particularly at "hot spots" where intense electromagnetic fields are produced in the vicinity of narrow nanogaps between metallic nanostructures. Therefore, developing new substrates with a high density of "hot spots" has been the recent topic of intense study. Here we report wrinkled nanoporous gold films that contain abundant Raman-active nanogaps produced by deformation and fracture of nanowire-like gold ligaments. This novel nanostructure yields ultrahigh surface enhanced Raman scattering for molecule detection.
Isolation and structure determination of a novel spiro-gamma-lactam, spiro-arogenate. (1983)

The eucaryotic microorganism, Neurospora crassa, is able under specified conditions (Zamir, L.O., Jung, E., and Jensen, R.A. (1982) J. Biol. Chem. 258, 6492-6496) to synthesize a cyclohexadienyl derivative of prephenic acid having the novel structure of a spiro-gamma-lactam. This L-gamma-(spiro-4-hydroxy-2,5-cyclohexadienyl)-pyroglutamate is herein given the trivial name, spiro-arogenate, to indicate its close relationship to the amino acid, L-arogenate. Spiro-arogenate is quantitatively converted to phenylalanine at mildly acidic pH and can be converted to arogenate by boiling at basic pH. The structure of spiro-arogenate was established through the application of spectroscopic techniques (ultraviolet, 1H-NMR, 13C-NMR, and mass spectrometry). The 1H-NMR and 13C-NMR spectra of spiro-arogenate isolated as the natural product conformed to the spectrum of spiro-arogenate prepared by chemical synthesis by S. Danishefsky and co-workers (Danishefsky, S., Morris, J., and Clizbe, L.A. (1981) J. Am. Chem. Soc. 103, 1602-1604). Circular dichroism established the S configuration of the asymmetric carbon at C-8 of spiro-arogenate.
Rapid Large-Scale Expansion of Functional Mesenchymal Stem Cells from Unmanipulated Bone Marrow Without Animal Serum (2008)

Adult mesenchymal stem cells (MSCs) are considered as valuable mediators for tissue regeneration and cellular therapy. This study was performed to develop conditions for regularly propagating a clinical quantity of > 2 x 10(8) MSCs without animal serum from small bone marrow (BM) aspiration volumes within short time. We established optimized culture conditions with pooled human platelet lysate (pHPL) replacing fetal bovine serum (FBS) for MSC propagation. MSC quality, identity, purity, and function were assessed accordingly. Biologic safety was determined by bacterial/fungal/mycoplasma/endotoxin testing and genomic stability by array comparative genomic hybridization (CGH). We demonstrate that unmanipulated BM can be used to efficiently initiate MSC cultures without the need for cell separation. Just diluting 1.5-5 mL heparinized BM per 500 mL minimum essential medium supplemented with L-glutamine, heparin, and 10% pHPL sufficiently supported the safe propagation of 7.8 +/- 1.5 x 10(8) MSCs within a single 11- to 16-day primary culture under defined conditions. This procedure also resulted in sustained MSC colony recovery. MSC purity, immune phenotype, and in vitro differentiation potential fully matched current criteria. Despite high proliferation rate, MSCs showed genomic stability in array CGH. This easy single-phase culture procedure can build the basis for standardized manufacturing of MSC-based therapeutics under animal serum-free conditions for dose-escalated cellular therapy and tissue engineering.
An Efficient Algorithm for Solving Distributed State Estimator and Laboratory Implementation (2005)

In this paper, we present a distributed constrained state estimator which takes the power flow balance constraints on zero injection buses as well as the bus voltage magnitude lying within the secure range into account so as to improve the accuracy of the estimated states. We propose an efficient algorithm that combines a projected Jacobi method with a parallel duality based method to solve the distributed constrained state estimation problem. The novel parallel duality based method possesses two decomposition effects, which not only make our method being parallel but also greatly increase the computational efficiency of our method. We have tested our method on several numerical examples, IEEE 30 bus system & IEEE 118 bus system and obtained successful result.
Redis Cookbook (2011)

Two years since its initial release, Redis already has an impressive list of adopters, including Engine Yard, GitHub, Craigslist, and Digg. This open source data structure server is built for speed and flexibility, making it ideal for many applications. If you're using Redis, or considering it, this concise cookbook provides recipes for a variety of issues you're likely to face. Each recipe solves a specific problem, and provides an in-depth discussion of how the solution works. Youll discover that Redis, while simple in nature, offers extensive functionality for manipulating and storing data.Learn when it makes sense to use Redis Explore several methods for installing Redis Connect to Redis in a number of ways, ranging from the command line to popular languages such as Python and Ruby Solve a range of needs, from linked datasets to analytics Handle backups, sharding, datasets larger than available memory, and many other tasks
Topical treatment with the opioid antagonist naltrexone accelerates the remodeling phase of full-thickness wound healing in type 1 diabetic rats (2013)

Wound repair involves a series of overlapping phases that include inflammation, proliferation, and tissue remodeling, with the latter phase requiring months for proper healing. Delays in any of these processes can result in infection, chronic ulceration, and possible amputation. Diabetes is a major risk factor for improper wound repair, and impaired wound healing is a major complication for more than 26 million people in the US diagnosed with diabetes. Previous studies have demonstrated that the opioid antagonist naltrexone (NTX) dissolved in moisturizing cream reverses delays in wound closure in streptozotocin-induced type 1 diabetic (T1D) rats. NTX accelerated DNA synthesis and increased the number of epithelial and mast cells, as well as new blood vessel formation. In this study, remodeling was evaluated in T1D rats up to eight weeks after initial wounding. Twenty days following wounding, diabetic rats treated with vehicle had elevated numbers of MMP-2+ fibroblasts, suggesting delayed healing processes; birefringence of granulation tissue stained with Sirius red revealed diminished collagen formation and maturation. Wound tissue from NTX-treated T1D rats had comparable numbers of MMP-2+ fibroblasts to control specimens, as well as accelerated maturation of granulation tissue. The integrity of wounded skin was evaluated by tensile strength measurements. T1D resulted in delayed wound healing, and wounded skin that displayed reduced tensile strength relative to normal rats. Topical NTX applied to wounds in T1D rats resulted in enhanced collagen formation and maturation over a 60-day period of time. Moreover, the force required to tear skin of NTX-treated T1D rats was elevated relative to the force necessary to tear the skin of vehicle-treated T1D rats, and comparable to that for normal rats. These data reveal that complications in wound healing associated with T1D involve the novel OGF-OGFr pathway, and that topical NTX is an effective treatment to enhance wound healing.
Bestimmung instantaner Strömungsgeschwindigkeitsprofile in der A. femoralis communis mit gepulstem Doppler-Ultraschall bei Stenosen und Verschlüssen der Beckenarterien (1974)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Prejunctional and peripheral effects of the cannabinoid CB1 receptor inverse agonist rimonabant (SR 141716) (2008)

Rimonabant is an inverse agonist specific for cannabinoid receptors and selective for their cannabinoid-1 (CB(1)) subtype. Although CB(1) receptors are more abundant in the central nervous system, rimonabant has many effects in the periphery, most of which are related to prejunctional modulation of transmitter release from autonomic nerves. However, CB(1) receptors are also expressed in, e.g., adipocytes and endothelial cells. Rimonabant inhibits numerous cardiovascular cannabinoid effects, including the decrease of blood pressure by central and peripheral (cardiac and vascular) sites of action, with the latter often being endothelium dependent. Rimonabant may also antagonize cannabinoid effects in myocardial infarction and in hypotension associated with septic shock or liver cirrhosis. In the gastrointestinal tract, rimonabant counteracts the cannabinoid-induced inhibition of secretion and motility. Although not affecting most cannabinoid effects in the airways, rimonabant counteracts inhibition of smooth-muscle contraction by cannabinoids in urogenital tissues and may interfere with embryo attachment and outgrowth of blastocysts. It inhibits cannabinoid-induced decreases of intraocular pressure. Rimonabant can inhibit proliferation of, maturation of, and energy storage by adipocytes. Among the many cannabinoid effects on hormone secretion, only some are rimonabant sensitive. The effects of rimonabant on the immune system are not fully clear, and it may inhibit or stimulate proliferation in several types of cancer. We conclude that direct effects of rimonabant on adipocytes may contribute to its clinical role in treating obesity. Other peripheral effects, many of which occur prejunctionally, may also contribute to its overall clinical profile and lead to additional indications as well adverse events.
Post growth rapid thermal annealing of GaN: The relationship between annealing temperature, GaN crystal quality, and contact-GaN interfacial structure (1997)

Microstructure of GaN films grown by metalorganic chemical-vapor-deposition (MOCVD) on c-sapphire substrates has been accessed as a function of post-growth rapid thermal annealing (RTA) temperatures from 600 °C to 800 °C. The influence of the thermally modified, near-surface crystalline quality on sputtered WSi contact to GaN was also evaluated. Similar planar defects were observed in all heat treated samples; only their density differed. Our analyses demonstrated a strong relationship between the improved GaN crystal quality and postgrowth high-temperature thermal processing. The density of the near-surface defects was lowered by 61% as the annealing temperature was raised from 600 °C to 800 °C. Depression of the near-surface defects encouraged development of the β-W2N interfacial phase and promoted metal-semiconductor interface smoothness.
Generative Adversarial User Model for Reinforcement Learning Based Recommendation System (2019)

There are great interests as well as many challenges in applying reinforcement learning (RL) to recommendation systems. In this setting, an online user is the environment; neither the reward function nor the environment dynamics are clearly defined, making the application of RL challenging. In this paper, we propose a novel model-based reinforcement learning framework for recommendation systems, where we develop a generative adversarial network to imitate user behavior dynamics and learn her reward function. Using this user model as the simulation environment, we develop a novel Cascading DQN algorithm to obtain a combinatorial recommendation policy which can handle a large number of candidate items efficiently. In our experiments with real data, we show this generative adversarial user model can better explain user behavior than alternatives, and the RL policy based on this model can lead to a better long-term reward for the user and higher click rate for the system.
In-Stent Thrombosis and Stenosis After Neck-Remodeling Device-Assisted Coil Embolization of Intracranial Aneurysms (2010)

From these results and those in the published literature, in-stent complication rates are low in carefully selected patients. The use of dual antiplatelet therapy, sensitivity assays, and glycoprotein IIb/IIIa inhibitors may decrease the rate of acute and chronic in-stent complications.
Loop-based subtraction of a single photon from a traveling beam of light (2018)

Manipulating light by adding and subtracting individual photons is a powerful approach with a principal drawback: the operations are fundamentally probabilistic and the probability is often small. This limits not only the fundamental scalability but also the number of operations that can be applied in realistic experimental settings. We propose and analyze a loop-based technique which can significantly increase the probability of success while preserving the quality of the photon subtraction. We show the improvement both in single mode preparation and manipulation of non-Gaussian states with negative Wigner functions and in two-mode entanglement distillation protocol with Gaussian states of light.
Automating skin disease diagnosis using image classification (2013)

Damilola Ayokunle Okuboyejo completed his first Master’s Degree at the age of 28 from University of Lagos, Nigeria. Couple with his years in Software Industry, He is currently engaged in research in the domain of Computational Intelligence and Image Analysis towards his second Master’s Degree at Tshwane University of Technology where he also delivers presentations on System Analysis and Design as a lecturer. Automating skin disease diagnosis using image classification
Global Adaptive Lyapunov-Based Control of a Robot and Mass-Spring System Undergoing An Impact Collision (2006)

The control of dynamic systems that undergo an impact collision is both theoretically challenging and of practical importance. An appeal of studying systems that undergo an impact is that short-duration effects such as high stresses, rapid dissipation of energy, and fast acceleration and deceleration may be achieved from low-energy sources. However, colliding systems present a difficult control challenge because the equations of motion are different when the system status changes suddenly from a non-contact state to a contact state. In this paper an adaptive nonlinear controller is designed to regulate the states of two dynamic systems that collide. The academic example of a planar robot colliding with an unactuated spring-mass system is used to represent a broader class of such systems. The control objective is defined as the desire to command a robot to collide with an unactuated system and regulate the spring-mass to a desired compressed state while compensating for the unknown constant system parameters. Lyapunov-based methods are used to develop a continuous adaptive controller that yields global asymptotic regulation of the spring-mass and robot links. It is interesting to note that one controller is responsible for achieving the control objective when the robot is in free motion (i.e., decoupled from the mass-spring system), when the systems collide, and when the system dynamics are coupled
Radial basis function networks in nonlinear signal processing applications (2002)

We consider radial basis function networks (RBFN) for use in various nonlinear signal processing applications. We first present a simple training algorithm for the RBFN based on stochastic gradients of error. We then demonstrate and discuss the usefulness of RBFNs in various applications including channel equalization, interference cancellation, time-series prediction, and nonlinear filtering.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Replication Slippage of Different DNA Polymerases Is Inversely Related to Their Strand Displacement Efficiency (1999)

Replication slippage is a particular type of error caused by DNA polymerases believed to occur both in bacterial and eukaryotic cells. Previous studies have shown that deletion events can occur in Escherichia coli by replication slippage between short duplications and that the main E. coli polymerase, DNA polymerase III holoenzyme is prone to such slippage. In this work, we present evidence that the two other DNA polymerases of E. coli, DNA polymerase I and DNA polymerase II, as well as polymerases of two phages, T4 (T4 pol) and T7 (T7 pol), undergo slippage in vitro, whereas DNA polymerase from another phage, 29, does not. Furthermore, we have measured the strand displacement activity of the different polymerases tested for slippage in the absence and in the presence of the E. coli single-stranded DNA-binding protein (SSB), and we show that: (i) polymerases having a strong strand displacement activity cannot slip (DNA polymerase from 29); (ii) polymerases devoid of any strand displacement activity slip very efficiently (DNA polymerase II and T4 pol); and (iii) stimulation of the strand displacement activity by E. coli SSB (DNA polymerase I and T7 pol), by phagic SSB (T4 pol), or by a mutation that affects the 3 3 5 exonuclease domain (DNA polymerase II exo and T7 pol exo ) is correlated with the inhibition of slippage. We propose that these observations can be interpreted in terms of a model, for which we have shown that high strand displacement activity of a polymerase diminishes its propensity to slip.
Influence of Drying and Irradiation on the Composition of Volatile Compounds of Thyme (Thymus vulgaris L.) (1996)

An investigation of the influence of air-drying, freeze-drying, γ- and β-irradiation and storage for up to 10 months on the composition of volatile compounds in thyme herb (Thymus vulgaris L.) is presented. Altogether, 70 constituents were identified (53 positively and 17 tentatively), including those considered most important for thyme flavour. Quantitative results did not reveal significant differences in the composition of irradiated and non-irradiated samples, and the reduction of the amount of some volatile compounds after drying was comparable for air-dried and freeze-dried herb. The largest changes in flavour composition were observed during storage, especially the reduction in the concentration of monoterpene hydrocarbons.
A protection scheme for mobile agents on Java (1997)

Article A protection scheme for mobile agents on Java Share on Authors: D. Hagimont SIRAC Project (IMAG-INRIA), INRIA, 655 av. de l'Europe, 38330 Montbonnot Saint-Martin, France SIRAC Project (IMAG-INRIA), INRIA, 655 av. de l'Europe, 38330 Montbonnot Saint-Martin, FranceView Profile , L. Ismail SIRAC Project (IMAG-INRIA), INRIA, 655 av. de l'Europe, 38330 Montbonnot Saint-Martin, France SIRAC Project (IMAG-INRIA), INRIA, 655 av. de l'Europe, 38330 Montbonnot Saint-Martin, FranceView Profile Authors Info & Claims MobiCom '97: Proceedings of the 3rd annual ACM/IEEE international conference on Mobile computing and networkingSeptember 1997 Pages 215–222https://doi.org/10.1145/262116.262149Online:26 September 1997Publication History 13citation488DownloadsMetricsTotal Citations13Total Downloads488Last 12 Months5Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
In vitro antioxidant and anti-inflammatory activities of Korean blueberry(Vaccinium corymbosum L.) extracts (2014)

at 1.7 mg/mL and 1.5 mg/mL,respectively)etc.The extracts were found to prevent inflammation as well by reducing nitric oxide production and cytotoxicity in cell.Conclusions:The findings suggest that the fresh Korean blueberry could be used as a source of natural antioxidants and anti-inflammatory agents.
Digital Data Transmission Systems of the Future (1961)

General predictions are made about the development of the state of the art by shortly reviewing the latest findings of theoretical investigations as well as hardware developments. A few examples are given to illustrate recent attempts to reorganize, standardize and integrate present day digital data processing and transmission systems for future use. Concepts of "data moving" and "dynamic matching" within a transmission network are introduced. It is believed that tele-data processing (TDP) systems, i.e., electronic data processing (EDP) systems with input/output devices at remote locations, will experience a growth that will warrant the specialization of a number of manufacturers and organizations on data moving only. Dynamic matching may be considered as the basic principle of a new organization of digital data-transmission networks. It will ultimately load every available communication channel to its practical peak capacity and will therefore optimize the efficiency of systems. This principle is discussed in detail at four different levels of a network. Demand matching of input devices, branch matching, link matching, and finally network matching will be a common feature of many systems in the 1970's. For the user of TDP facilities, data movers will incorporate these principles in "general services" networks, which will operate on a message switched basis and in completely digital form. "Private facilities" will also be provided on a circuit switched basis for special purposes.
Single-Molecule and Superresolution Imaging in Live Bacteria Cells (2010)

Single-molecule imaging enables biophysical measurements devoid of ensemble averaging, gives enhanced spatial resolution beyond the diffraction limit, and permits superresolution reconstructions. Here, single-molecule and superresolution imaging are applied to the study of proteins in live Caulobacter crescentus cells to illustrate the power of these methods in bacterial imaging. Based on these techniques, the diffusion coefficient and dynamics of the histidine protein kinase PleC, the localization behavior of the polar protein PopZ, and the treadmilling behavior and protein superstructure of the structural protein MreB are investigated with sub-40-nm spatial resolution, all in live cells.
Spread of Vibrio cholerae 0139 Bengal in India (1994)

Vibrio cholerae serogroup O139 Bengal, a novel strain with epidemic potential, completely displaced V. cholerae serogroup 01 in Calcutta in January 1993, which was followed by an epidemic caused by V. cholerae O139 in March-May 1993. From November 1992 to July 1993, 95.6% of 916 V. cholerae isolates submitted to the National Institute of Cholera and Enteric Diseases from 28 locations in India were confirmed as serogroup O139. As of July 1993, V. cholerae O139 had been isolated from 13 Indian states and a union territory, and large outbreaks of cholera caused by the O139 serogroup had occurred in several cities. The extent of spread of V. cholerae O139 Bengal in India and its ability to swiftly disseminate leaves little doubt that this is the beginning of the eighth pandemic of cholera.