gebhart/patrepeval huggingface dataset:
Influence of Surface Morphology on the Wettability of Microstructured ZnO-Based Surfaces (2008)

The effect of sample microstructure on water dynamic wetting behavior was examined for superhydrophobic ZnO films. Surface morphology ranging from needle arrays to overlapping platelets was controlled through judicious choice of hydrothermal reaction conditions. Structure modification with alkyl and perfluoroalkyl chains yielded films characterized by advancing contact angles that ranged from 159° to 171°. Contact angle hysteresis was less than 2° with needles (tip diameter <30 nm) and less than 11° for rods (diameter <250 nm). Relatively thick (diameter ∼600 nm) structures were still characterized by advancing contact angles exceeding 165° and hysteresis <30°. Formation of nanometer-scale roughness on top of the microstructure via silica deposition significantly enhanced the surface superhydrophobicity. Similarly, following perfluoroalkane treatment, all examined microstructures exhibited advancing contact angles >169° and hysteresis <7°.
2-Hydroxy-2,2-dimethylacetic Acid Ester Derived Heterobiaryl Ethers Containing 1,3,5-Triazine Substituents (1995)

The 1,3,5-triazines 3 were obtained from methyl 4-formylbenzoate (4) in a multistep synthesis by first introducing the ester unit under Williamson conditions. Subsequently, the 1,3,5-triazine ring was synthesized by reaction of isocyanates with 1,3-diazadienes obtained from N-silylimines.
Long short-term memory and learning-to-learn in networks of spiking neurons (2018)

Recurrent networks of spiking neurons (RSNNs) underlie the astounding computing and learning capabilities of the brain. But computing and learning capabilities of RSNN models have remained poor, at least in comparison with artificial neural networks (ANNs). We address two possible reasons for that. One is that RSNNs in the brain are not randomly connected or designed according to simple rules, and they do not start learning as a tabula rasa network. Rather, RSNNs in the brain were optimized for their tasks through evolution, development, and prior experience. Details of these optimization processes are largely unknown. But their functional contribution can be approximated through powerful optimization methods, such as backpropagation through time (BPTT). A second major mismatch between RSNNs in the brain and models is that the latter only show a small fraction of the dynamics of neurons and synapses in the brain. We include neurons in our RSNN model that reproduce one prominent dynamical process of biological neurons that takes place at the behaviourally relevant time scale of seconds: neuronal adaptation. We denote these networks as LSNNs because of their Long short-term memory. The inclusion of adapting neurons drastically increases the computing and learning capability of RSNNs if they are trained and configured by deep learning (BPTT combined with a rewiring algorithm that optimizes the network architecture). In fact, the computational performance of these RSNNs approaches for the first time that of LSTM networks. In addition RSNNs with adapting neurons can acquire abstract knowledge from prior learning in a Learning-to-Learn (L2L) scheme, and transfer that knowledge in order to learn new but related tasks from very few examples. We demonstrate this for supervised learning and reinforcement learning.
Sea surface velocities from sea surface temperature image sequences: 2. Application to the Brazil‐Malvinas Confluence area (2000)

An inverse variational model is applied to four exceptionally cloud‐free sea surface temperature image sequences of the Brazil‐Malvinas Confluence area for the purpose of estimating sea surface velocity fields. The velocity fields are constructed by minimizing a mixed layer integrated form of the heat balance equation while the horizontal divergence and vorticity of the flow field are controlled. The source terms involved in the heat balance are determined by fitting a polynomial to diurnal temperature variations as a function of temperature and longitude. A sensitivity study of the solution to perturbations of the weights imposed to the constraints on divergence and vorticity as well as of the representation of the source terms yields error fields associated with the velocity. A comparison of the estimated velocity fields with available concomitant in situ velocity measurements shows that the fields are realistic. Errors are of the order of 15–20% in magnitude and 20°–25° in direction. These errors fall within the error bars of 25–30% in magnitude and of 30°–35° in direction, except for the summer image series. Surface velocities of 0.5–0.6 m s −1 are obtained across the Malvinas Current. They are > 1 m s −1 in the frontal region, in the Brazil Current overshoot, and in warm and cold core rings and vary between 0.3 and 0.8 m s −1 in the Brazil Current. With some hypotheses on the vertical shear of the horizontal flow the transport of the Malvinas Current is estimated to be 25±5 Sv between 41° and 40°S.
Induction of thymomas by <i>N</i>-methyl-<i>N</i>-nitrosourea in AKR mice: interaction between the chemical carcinogen and endogenous murine leukaemia viruses (1987)

AKR mice develop thymomas spontaneously when greater than 6 months old but when young AKR mice are treated with N-methyl-N-nitrosourea (MNU) they develop thymomas at 3-6 months of age. In this study the potential role of oncogene activation in the development of both the spontaneous and MNU-induced thymomas in AKR mice has been examined by DNA transfection into NIH3T3 mouse fibroblasts and by Southern analysis of tumour DNA. The results show that a high proportion of MNU-induced thymomas contain activated cellular rasK while no activated cellular ras genes were detected in spontaneous thymomas. Southern analysis of tumour DNA revealed that 2/30 spontaneous tumours and 2/52 MNU-induced tumours contained alterations in the c-myc gene while 5/29 spontaneous tumours and 6/56 MNU-induced tumours contained alterations in the Pim-1 gene. A more detailed analysis of the Pim-1 gene demonstrated that the alterations observed in most MNU-induced and spontaneous tumours resulted from proviral integration at the 3' end of this gene. Our analyses also demonstrated that the majority of MNU-induced tumours, including those containing rearrangements in the Pim-1 gene, lacked the somatically acquired recombinant MCF proviruses that are present in most spontaneous AKR lymphomas. These results provide evidence that the mechanisms of development of MNU-induced and spontaneous tumours in AKR mice are distinct and the development of thymomas that contain proviral integrations at the Pim-1 locus in the MNU-treated AKR mice involve cooperation between the chemical carcinogen and endogenous murine leukaemia viruses.
The Role of Enteroviral Infections in the Development of IDDM: Limitations of Current Approaches (1997)

Enteroviruses have been examined for their possible role in the etiology of IDDM for nearly 40 years, yet the evidence remains inconclusive. The mechanism of acute cytolytic infection of beta-cells, proposed by earlier studies, appears to be incompatible with the long preclinical period of autoimmunity preceding IDDM. Advances in molecular biology have improved our understanding of enteroviral biology and of potential alternative pathogenic mechanisms through which enteroviruses may cause diabetes. The focus of future human studies will likely shift from people with IDDM to those with prediabetic autoimmunity to determine whether acute enteroviral infections can promote progression from autoimmunity to overt diabetes. We propose that such studies use assays to detect enteroviral RNA, in addition to IgM serology. RNA assays can overcome sensitivity and type-specificity limitations of IgM assays as well as identify diabetogenic strains of enteroviruses, if such exist. Evaluation of the role of enteroviruses in triggering beta-cell autoimmunity in humans will require large prospective studies of young children. The Diabetes Autoimmunity Study in the Young--one of very few such studies currently underway--is focusing on potential interactions between HLA class II genes and enteroviral infections. Future studies will likely examine interactions between viral infections and non-HLA IDDM candidate genes, including those that may determine beta-cell tropism of candidate viruses.
<title>Monte Carlo model for SEM linewidth metrology</title> (1994)

A scanning electron microscope (SEM) can be used to measure the dimensions of the microlithographic features of integrated circuits. However, without a good model of the electron-beam/specimen interaction, accurate edge location cannot be obtained. A Monte Carlo code has been developed to model the interaction of an electron beam with a line lithographically produced on a multi-layer substrate. The purpose of the code is to enable one to extract the edge position of a line from SEM measurements. It is based on prior codes developed at NIST, but with a new formulation for the atomic scattering cross sections and the inclusion of a method to simulate edge roughness or rounding. The code is currently able to model the transmitted and backscattered electrons, and the results from the code have been applied to the analysis of electron transmission through a gold line on a thin silicon substrate, such as used in an x-ray lithographic mask.
IL-33 is a crucial amplifier of innate rather than acquired immunity (2010)

IL-33, a member of the IL-1-related cytokines, is considered to be a proallergic cytokine that is especially involved in Th2-type immune responses. Moreover, like IL-1α, IL-33 has been suggested to act as an "alarmin" that amplifies immune responses during tissue injury. In contrast to IL-1, however, the precise roles of IL-33 in those settings are poorly understood. Using IL-1- and IL-33-deficient mice, we found that IL-1, but not IL-33, played a substantial role in induction of T cell-mediated type IV hypersensitivity such as contact and delayed-type hypersensitivity and autoimmune diseases such as experimental autoimmune encephalomyelitis. Most notably, however, IL-33 was important for innate-type mucosal immunity in the lungs and gut. That is, IL-33 was essential for manifestation of T cell-independent protease allergen-induced airway inflammation as well as OVA-induced allergic topical airway inflammation, without affecting acquisition of antigen-specific memory T cells. IL-33 was significantly involved in the development of dextran-induced colitis accompanied by T cell-independent epithelial cell damage, but not in streptozocin-induced diabetes or Con A-induced hepatitis characterized by T cell-mediated apoptotic tissue destruction. In addition, IL-33-deficient mice showed a substantially diminished LPS-induced systemic inflammatory response. These observations indicate that IL-33 is a crucial amplifier of mucosal and systemic innate, rather than acquired, immune responses.
Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways (2013)

We previously reported that glucagon-like peptide-1 (GLP-1) appearance in the portal vein facilitates hepatic vagal afferent activity, and this further augments reflexively the pancreatic vagal efferents in anesthetized rats, suggesting a neuroincretin effect of GLP-1. To determine whether the GLP-1-induced vagal pathways lead to a neuronal-mediated component (NMC) of insulin secretion, we infused GLP-1 at a physiological or pharmacological dose (1 or 3 pmol·kg(-1)·min(-1), respectively) into the portal vein in conscious rats with selective hepatic vagotomy (Vagox) or sham operation (Sham). The experiments consisted of two sequential 10-min intraportal infusions (P1 and P2): glucose at a physiological rate (56 μmol·kg(-1)·min(-1)) in P1 and the glucose plus GLP-1 or vehicle in P2. Under arterial isoglycemia across the groups, the physiological GLP-1 infusion in Sham augmented promptly and markedly arterial insulin levels, approximately twofold the levels in glucose alone infusion (P < 0.005), and insulin levels in Vagox diminished apparently (P < 0.05). Almost 60% of the GLP-1-induced insulin secretion (AUC) in Sham met the NMC, i.e., difference between insulin secretion in Sham and Vagox, (AUC 976 ± 65 vs. 393 ± 94 pmol·min/l, respectively, P < 0.005). Intraportal pharmacological GLP-1 infusion further augmented insulin secretion in both groups, but the NMC remained in 46% (NS; Sham vs. Vagox). In contrast, "isoglycemic" intravenous GLP-1 infusion (3 pmol·kg(-1)·min(-1)) evoked an equal insulin secretion in both groups. Thus, the present results indicate that GLP-1 appearing in the portal vein evokes a powerful neuronal-mediated insulinotropic effect, suggesting the neuroincretin effect.
Laser assisted immunotherapy (LIT) for chemotherapy-resistant neoplasms: recent case reports (2014)

T-cell stimulators such as anti-CTLA-4 antibodies enhance immunologic responses to chemotherapy-resistant solid tumors, such as melanoma, advanced breast cancer, ovarian cancer and pancreatic cancer. The efficacy of these new immunotherapy agents can in theory be enhanced substantially by therapies that stimulate new immunologic (T-cell) responses against the tumor. Laser immunotherapy (LIT) with imiquimod and InCVAX are techniques that produce useful responses in patients with advanced melanoma, the prototypical chemotherapy resistant solid tumor. The mechanism of action of these therapies is thought to be immunological, including the development of new T-cell responses. We have therefore been combining LIT using imiquimod and InCVAX treatment with the new T-cell stimulators (ipilimumab) in cases of stage IV melanoma. While still anecdotal, the use of novel combinations of immunologic therapies should provide much improved responses for chemotherapy-resistant solid tumors (such as melanoma) than was previously possible. Newer T-cell stimulating drugs such as the anti-PD-1 antibodies and anti-PD-L1 antibodies will make this general approach to treating chemoresistant advanced tumors even more effective in the future.
(Neonatal) Retinoblastoma in the First Month of Life (2002)

The most common manifesting sign of children diagnosed as having retinoblastoma in the first month of life is family history. Eyes with Reese-Ellsworth group I retinoblastomas were the most common. In patients with bilateral and unilateral retinoblastoma, new (subsequent) ocular tumors developed in a centrifugal pattern. Despite an early diagnosis, patients' eyes came to enucleation, and metastatic disease and death occurred from ocular metastases. In patients who received radiation therapy, the probability of developing second nonocular cancer is 54% by 23.7 years; no second cancers developed in patients who did not receive radiation therapy.
Chlamydia pneumoniae infection in acute exacerbations of COPD (1993)

Chlamydia pneumoniae, strain TWAR, is a frequent causative agent of acute respiratory disease. We assessed the incidence and prevalence of Chlamydia pneumoniae infections in COPD. We studied, from January 1990 to May 1991, 142 out-patients with acute purulent exacerbations of chronic obstructive pulmonary disease (COPD) and 114 healthy control subjects. Oropharyngeal swab specimens were collected at each exacerbation and analysed using a high definition monoclonal indirect fluorescent antibody test for Chlamydia pneumoniae identification. Immunoglobulins G and M (IgG and IgM) fractions of antibodies to Chlamydia pneumoniae were studied by microimmunofluorescence test. Prevalence of specific IgG was 63% in COPD, and 46% in controls (Chi-squared test p = 0.007). Moreover, mean titre of IgG was significantly higher in COPD than in controls. Five patients were positive for specific IgM (> or = = 1:16), and one had a fourfold increase of IgG titre; four of these patients had been treated with ciprofloxacin 1 g.day-1 for 10 days, and two with erythromycin, 3 g.day-1 for 14 days, with remission of signs and symptoms of exacerbation. Chlamydia pneumoniae identification was always negative. Our data suggest that Chlamydia pneumoniae infection is a rather frequent event in COPD, since at least 4% of exacerbations may be associated with it.
COASTAL ENGINEERING 2004 (2004)

*** Available Only Through World Scientific *** http://www.worldscibooks.com/engineering/5808.html  This comprehensive and up-to-date volume contains 367 papers presented at the 29th International Conference on Coastal Engineering, held in Lisbon, Portugal, 19–24 September 2004. It is divided into five parts: waves; long waves, nearshore currents, and swash; sediment transport and morphology; coastal management, beach nourishment, and dredging; coastal structures. The contributions cover a broad range of topics including theory, numerical and physical modeling, field measurements, case studies, design, and management. Coastal Engineering 2004 provides engineers, scientists, and planners state-of-the-art information on coastal engineering and coastal processes
Implementing Signatures for Transactional Memory (2007)

Transactional Memory (TM) systems must track the read and write sets - items read and written during a transaction - to detect conflicts among concurrent transactions. Several TMs use signatures, which summarize unbounded read/write sets in bounded hardware at a performance cost of false positives (conflicts detected when none exists). This paper examines different organizations to achieve hardware-efficient and accurate TM signatures. First, we find that implementing each signature with a single k-hash- function Bloom filter (True Bloom signature) is inefficient, as it requires multi-ported SRAMs. Instead, we advocate using k single-hash-function Bloom filters in parallel (Parallel Bloom signature), using area-efficient single-ported SRAMs. Our formal analysis shows that both organizations perform equally well in theory and our simulation- based evaluation shows this to hold approximately in practice. We also show that by choosing high-quality hash functions we can achieve signature designs noticeably more accurate than the previously proposed implementations. Finally, we adapt Pagh and Rodler's cuckoo hashing to implement Cuckoo-Bloom signatures. While this representation does not support set intersection, it mitigates false positives for the common case of small read/write sets and performs like a Bloom filter for large sets.
Photouncaging Nanoparticles for MRI and Fluorescence Imaging<i>in Vitro</i>and<i>in Vivo</i> (2013)

Multimodal and multifunctional nanomaterials are promising candidates for bioimaging and therapeutic applications in the nanomedicine settings. Here we report the preparation of photouncaging nanoparticles with fluorescence and magnetic modalities and evaluation of their potentials for in vitro and in vivo bioimaging. Photoactivation of such bimodal nanoparticles prepared using photouncaging ligands, CdSe/ZnS quantum dots, and super paramagnetic iron oxide nanoparticles results in the systematic uncaging of the particles, which is correlated with continuous changes in the absorption, mass and NMR spectra of the ligands. Fluorescence and magnetic components of the bimodal nanoparticles are characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and elemental analyses using energy dispersive X-ray (EDX) spectroscopy and X-ray photoelectron spectroscopy (XPS). Bioconjugation of the nanoparticles with peptide hormones renders them with biocompatibility and efficient intracellular transport as seen in the fluorescence and MRI images of mouse melanoma cells (B16) or human lung epithelial adenocarcinoma cells (H1650). Biocompatibility of the nanoparticles is evaluated using MTT cytotoxicity assays, which show cell viability over 90%. Further, we combine MRI and NIR fluorescence imaging in C57BL/6 (B6) mice subcutaneously or intravenously injected with the photouncaging nanoparticles and follow the in vivo fate of the nanoparticles. Interestingly, the intravenously injected nanoparticles initially accumulate in the liver within 30 min post injection and subsequently clear by the renal excretion within 48 h as seen in the time-dependent MRI and fluorescence images of the liver, urinary bladder, and urine samples. Photouncaging ligands such as the ones reported in this article are promising candidates for not only the site-specific delivery of nanomaterials-based contrast agents and drugs but also the systematic uncaging and renal clearance of nanomaterials after the desired in vivo application.
Corrosion of Reinforcing Steel in Concrete Containing Slag or Pozzolans (1990)

Abstract Use of fly ash, silica fume, natural pozzolans, and blast-furnace slag in concrete is becoming increasingly common. Incorporation of these materials improves the durability of concrete. But as yet there are few quantitative data available on the effect of these materials on long-term corrosion of steel reinforcement. Such data will help the concrete technologists to select the proper type of materials to produce dense and impermeable concrete to withstand aggressive service environments. In this investigation, the long-term corrosion-resisting characteristics of concretes made with two fly ashes, a natural pozzolan, a blast-furnace slag cement, and a preblended portland-fly ash cement were evaluated. Specimens were immersed in 5% sodium chloride solution for a period of more than five years, and the corrosion activity was evaluated by monitoring the half-cell potentials and measuring the corrosion rate of embedded steel using linear polarization resistance technique. Results indicate that addition of pozzolans or slag increases the corrosion-resisting characteristics of concrete. The corrosion rate of steel in concrete made with blast-furnace slag cement is lower than in other concretes.
Barcode-Assisted Planar Object Tracking Method for Mobile Augmented Reality (2011)

In this paper, we propose a planar target tracking method that exploits a barcode containing information about a target. Our method combines both barcode detection and natural feature tracking methods to track a planar object efficiently on mobile devices. A planar target is detected by recognizing the barcode located near the target, and the target's keypoints are tracked in video sequences. We embed the information related to a planar object into the barcode, and the information is used to limit image regions to perform keypoint matching between consecutive frames. We show how to detect a barcode robustly and what information is embedded for efficient tracking. Our detection method runs at 30 fps on modern mobile devices, and it can be used for mobile augmented reality applications using planar targets.
Synthesis, physicochemical, thermal, and XRD/HSA interactions of mixed [Cu(Bipy)(Dipn)](X)<sub>2</sub> complexes: DNA binding and molecular docking evaluation (2020)

Two water-soluble dicationic complexes, [Cu(bipy)(dipn)](BF4)2 (1) and [Cu(bipy)(dipn)](NO3)2 (2) (bipy = 2.2-bipyridine and dipn = dipropylenetriamine), were synthesized in high yields. The desired complexes were characterized by CHN-EA, UV–Vis, SEM, EDS, FT-IR, TGA, and XRD. The single-crystal XRD of [Cu(bipy)(dipn)](BF4)2 reflected that Cu(II) complex is formed in a distorted square pyramid configuration. The Hirshfeld surface analysis (HSA) confirmed more powerful atom–atom interaction, the hydrogen bonding in H…F, supporting the outcome of XRD. The influences of the CT-DNA/complexes were gathered by viscosity, CV, and electronic absorption measurements. The estimated binding constants (Kb) for 1 and 2 were 4.5 × 104 and 3.4 × 104 M−1, respectively. Complex 2 revealed slightly poorer DNA binding capability than 1. Eventually, the molecular docking of [Cu(bipy)(dipn)]+2 species was evaluated and demonstrated employing 1BNA-DNA segment.