gebhart/patrepeval huggingface dataset:
Comparison of memory fMRI response among normal, MCI, and Alzheimer’s patients (2003)

MCI and AD patients had less medial temporal lobe activation on the memory task than the normal subjects but similar activation as normal subjects on the sensory task. These findings suggest decreased medial temporal activation may be a specific marker of limbic dysfunction due to the neurodegenerative changes of AD. In addition, fMRI is sufficiently sensitive to detect changes in the prodromal, MCI, phase of the disease.
Photothermal compression of colloidal crystals (1991)

Dyed sulfonated polystyrene spheres (83 nm diameter) self-assemble into regular crystalline arrays that Bragg diffract visible light. Absorption of high intensity radiation (&gt;25 W/cm2) by the dye results in a local compression of the crystalline array due to local heating. The Kossel ring pattern is used to probe the variation in the lattice parameter and the dynamics of the thermally induced compression. The thermally induced compression derives from the negative temperature dependence of the interparticle interaction potential.
The MPI CyberMotion Simulator: A Novel Research Platform to Investigate Human Control Behavior (2013)

The MPI CyberMotion Simulator provides a unique motion platform, as it features an anthropomorphic robot with a large workspace, combined with an actuated cabin and a linear track for lateral movement. This paper introduces the simulator as a tool for studying human perception, and compares its characteristics to conventional Stewart platforms. Furthermore, an experimental evaluation is presented in which multimodal human control behavior is studied by identifying the visual and vestibular responses of participants in a roll-lateral helicopter hover task. The results show that the simulator motion allows participants to increase tracking performance by changing their control strategy, shifting from reliance on visual error perception to reliance on simulator motion cues. The MPI CyberMotion Simulator has proven to be a state-of-the-art motion simulator for psychophysical research to study humans with various experimental paradigms, ranging from passive perception experiments to active control tasks, such as driving a car or flying a helicopter.
Design of Thermally Robust Clock Trees Using Dynamically Adaptive Clock Buffers (2009)

On-chip temperature gradient has emerged as a major design concern for high-performance integrated circuits for the current and future technology nodes. Clock skew is an undesirable phenomenon for synchronous digital circuits that is exacerbated by the temperature difference between various parts of the clock tree. The main aim of this paper is to provide intelligent solution for minimizing the temperature-dependent clock skew by designing dynamically adaptive circuit elements, particularly the clock buffers. Using an <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">RLC</i> model of the clock tree, we investigate the effect of on-chip temperature gradient on the clock skew for a number of temperature profiles that can arise in practice due to different architectures and applications. As an effective way of mitigating the variable clock skew, we present an adaptive circuit technique that senses the temperature of different parts of the clock tree and adjusts the driving strengths of the corresponding clock buffers dynamically to reduce the clock skew. Simulation results demonstrate that our adaptive technique is capable of reducing the skew by up to 92.4%, leading to much improved clock synchronization and design performance.
Generalized Third-Party Call Control in SIP Networks (2008)

Third-party call control (3PCC) is essential to implementing advanced services in Voice-over-IP (VoIP) networks. It allows intermediary applications to control how the media streams of endpoint devices are connected together. However the Session Initiation Protocol (SIP), the widely adopted open standard for VoIP signaling, presents a number of challenges that make 3PCC in SIP complex and prone to errors. Previously proposed solutions only address operations under ideal conditions and thus are incomplete. Furthermore, the problem of compositional 3PCC by multiple applications has not been addressed. In this paper, we propose a general solution for robust and comprehensive media connectivity control. The solution has been verified, and allows multiple applications operating concurrently in a call path to interoperate successfully.
Apparent Nuclear Transmutations without Neutron Emission Triggered by Pseudoprotons (2015)

In this paper, we review the work by Don Carlo Borghi and R. M. Santilli on the laboratory synthesis of the neutron from the proton and the electron under the laws of hadronic mechanics. We then review the prediction of a subsequent synthesis, this time, of the neutron and the electron into a new particle, known as Santilli pseudoproton, which has essentially the same characteristics of the neutron except being negatively charged. We then outline, apparently for the first time, ongoing research on esoenergetic nuclear transmutations without neutron emission that are triggered by a flux of Santilli pseudoprotons.
A Selective Instant Synthesis of a Coordination Network and Its Ab Initio Powder Structure Determination (2008)

Fast powders and slow crystals: A uniform powder sample of a flexible porous coordination network is prepared in high yield by kinetically controlled synthesis and its crystal structure solved by synchrotron ab initio powder X-ray diffraction (see picture). Crystals of a totally different porous network with larger channels for guest encapsulation are also obtained by thermodynamic control in a slow crystallization process.
Intraoperative Antibiotic Wound Lavage (1977)

Intraoperative antibiotic wound lavage has been used in all arterial reconstructive procedures for the past 7 years and reduced the incidence of early and late postoperative infections from 1.5% in 400 operations prior to 1969 to 0.23% (one post-hospital) in 434 patients operated since that date. In 226 consecutive clean major general surgical procedures since June 1971 there has been no early or late wound infections following intraoperative antibiotic wound lavage in contrast to an infection rate of 1.5% in 185 operations prior to that date. A double blind study of 200 patients undergoing operations for varicose veins was carried out as follows: The wounds of alternate patients were irrigated either with normal saline or with antibiotic solution. There were no gross (grade II) postoperative wound infections. Minor skin changes were noted in 93 of 632 incisions in the saline group and only 49 of 608 incisions irrigated with antibiotic solution (P less than 0.001). In clean operations without antibiotic wound lavage there was a 0.73% rate of in-hospital wound infections in 685 patients in contrast to a zero rate in 760 patients wherein intraoperative wound lavage was carried out throughout the operative procedure.
Breicht über einige neue Einrichtungen des Königl. Zoologischen und Anthropologisch-Ethnographischen Museums in Dresden: Modelle von Waltieren und ihre Herstellung (1912)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
REVIEWS Worlds Apart. Structural parallels in the poetry of Paul Valéry, Saint-John Perse, Benjamin Péret and René Char. By JACKSONELIZABETH R.. (De Proprietatibus Litterarum. Series Practica, 106). The Hague-Paris: Mouton. 1976. 256 pp. F1. 58. (1981)

Journal Article REVIEWS Get access Worlds Apart. Structural parallels in the poetry of Paul Valéry, Saint-John Perse, Benjamin Péret and René Char. By ELIZABETH R. JACKSON. (De Proprietatibus Litterarum. Series Practica, 106). The Hague-Paris: Mouton. 1976. 256 pp. F1. 58. F. R. SMITH F. R. SMITH LONDON Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XXXV, Issue 1, January 1981, Pages 91–92, https://doi.org/10.1093/fs/XXXV.1.91 Published: 01 January 1981
Suppression of Hepatitis C Virus Replicon by RNA Interference Directed against the NS3 and NS5B Regions of the Viral Genome (2004)

RNA interference (RNAi) is a phenomenon in which small interfering RNA (siRNA), an RNA duplex 21 to 23 nucleotides (nt) long, or short hairpin RNA (shRNA) resembling siRNA, mediates degradation of the target RNA molecule in a sequence-specific manner. RNAi is now expected to be a useful therapeutic strategy for hepatitis C virus (HCV) infection. In the present study we compared the efficacy of a number of shRNAs directed against different target regions of the HCV genome, such as 5'-untranslated region (5'UTR) (nt 286 to 304), Core (nt 371 to 389), NS3-1 (nt 2052 to 2060), NS3-2 (nt 2104 to 2122), and NS5B (nt 7326 to 7344), all of which except for NS5B are conserved among most, if not all, HCV subtype 1b (HCV-1b) isolates in Japan. We utilized two methods to express shRNAs, one utilizing an expression plasmid (pAVU6+27) and the other utilizing a recombinant lentivirus harboring the pAVU6+27-derived expression cassette. Although 5'UTR has been considered to be the most suitable region for therapeutic siRNA and/or shRNA because of its extremely high degree of sequence conservation, we observed only a faint suppression of an HCV subgenomic replicon by shRNA against 5'UTR. In both plasmid-and lentivirus-mediated expression systems, shRNAs against NS3-1 and NS5B suppressed most efficiently the replication of the HCV replicon without suppressing host cellular gene expression. Synthetic siRNA against NS3-1 also inhibited replication of the HCV replicon in a dose-dependent manner. Taken together, the present results imply the possibility that the recombinant lentivirus expressing shRNA against NS3-1 would be a useful tool to inhibit HCV-1b infection.
An analysis package comparing PID anti-windup strategies (1995)

This article describes software developed in SIMULINK that enables the behavior of feedback control systems with actuator saturation and PID controllers to be evaluated. The software, which is part command- and part menu-driven, allows a choice of four PID controllers using different integral wind-up strategies and transfer function entry of the actuator and plant dynamics. Most realistic control systems contain nonlinearities of some form. One nonlinearity commonly found in control systems is a saturating element. If integral control is applied to such a system to eliminate steady state error, an undesired side effect known as integrator windup may occur when large setpoint changes are made. This effect leads to a characteristic step response with a large overshoot and a very high settling time. To avoid this situation, many different anti-windup strategies have been suggested. This article discusses a software package that has been developed in the SIMULINK/MATLAB environment to investigate and compare the performance of four different anti-windup implementations for PI or PID controllers. The software is partially menu-driven and enables the user to easily enter his own actuator and plant transfer functions to study the performance with the different controllers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Therapeutic Effect of Supercritical CO<sub>2</sub> Extracts of <i>Curcuma</i> Species with Cancer Drugs in Rhabdomyosarcoma Cell Lines (2015)

Synergistic effect of supercritical CO2 extracts of Curcuma species with conventional chemotherapeutic drugs was investigated in human alveolar (SJRH30) and embryonal (RD) rhabdomyosarcoma cell lines. The Curcuma amada (mango ginger) (CA) extract showed the highest levels of cytotoxicity with inhibitory concentration IC50 values of 7.133 µg/ml and 7.501 µg/ml for SJRH30 and RD cell lines, respectively, as compared with Curcuma longa (turmeric) and Curcuma xanthorrhiza (Javanese turmeric) extracts. CA showed synergistic cytotoxic effects with vinblastine (VBL) and cyclophosphamide (CP) as indicated by the combination index values of <1 for VBL + CA, CP + CA, and VBL + CP + CA combinations in both embryonal and alveolar rhabdomyosarcomas. When lower doses of CA (0.1-0.2 µg/ml) were combined with cancer drugs like CP and VBL, caspase-3 activity increased significantly compared with individual agents and correlated with the percentage of apoptotic cells. CA in combination with VBL and CP induced a higher percentage of apoptosis than single agents in both cell lines. CA also modulated the expression of genes associated with intrinsic pathway of apoptosis (Bcl-2, Bax, Bak, and p53) and also inhibited the expression of genes associated with inflammation such as COX-2 and NF-κB. Xenograft studies with SJRH30 tumors in nude mice showed that CA treatment inhibited tumor growth rate with and without VBL and increased the survival rate significantly. These results suggest that CA can be evaluated further as an adjuvant with cancer drugs for the treatment of rhabdomyosarcoma patients. Copyright © 2015 John Wiley & Sons, Ltd.
Predicting Sensory Data and Extending Battery Life for Wearable Devices (2017)

Telepath is a framework that supports communication-free offloading for wearable devices. With offline training, activity recognition tasks can be offloaded from the wearable to the user's phone, without transferring raw sensing data. The key observation is that when the user is carrying both devices, the sensing streams on the two devices are highly correlated. By exploiting the correlation, the phone can estimate the wearable's sensing data and emulate the watch. Our evaluations shows that with Telepath, the phone performs accurately on activity recognition tasks that are designed for smart watches, achieving on average 87% of the watch's accuracy while extending the watch's battery life by 2.1x.
Comparison of efficacy and safety of choline fenofibrate (fenofibric acid) to micronized fenofibrate in patients of mixed dyslipidemia: A randomized, open-label, multicenter clinical trial in Indian population (2015)

Choline fenofibrate delayed release 135 mg is as safe and effective as 160 mg of micronized fenofibrate in Indian patients with mixed dyslipidemia.
Upregulation of prolylcarboxypeptidase (PRCP) in lipopolysaccharide (LPS) treated endothelium promotes inflammation (2009)

The increased PRCP lead to a sustained production of bradykinin in endothelium following LPS treatment. This amplification may be an additional mechanism whereby PRCP promotes a sustained inflammatory response. A better appreciation of the role of PRCP in endothelium may contribute to a better understanding of inflammatory vascular disorders and to the development of a novel treatment.
Deep Convolutional Neural Network for Decompressed Video Enhancement (2016)

Block-wise intra/inter prediction, transformation and quantization used in block-based hybrid video coding will inevitably result in blocking artifacts, especially at the low bit rate. To address this problem, this paper employs a deep convolutional neural network (CNN) to approximate the reverse function of video compression, motived by the great success of deep learning in computer vision fields recently. The proposed method establishes an end-to-end mapping, represented as the CNN, which takes the decompressed frame as input and outputs the enhanced one. Employing numerous sequences compressed by H.264 and HEVC reference software, the proposed CNN learns the connections between the lossy frame and the original one in an implicit way under different quantization parameters (QP). Figure 1 shows the architecture of our CNN and the pipeline of the network training. We build our network with convolution layers and ReLU layer and the weights and biases of all the convolution layers in our model are updated by minimizing the loss using stochastic gradient descent with the standard backpropagation. We implement the CNN as a post-loop deblocking filter and explore varying CNN parameters for different QPs. Various experimental results demonstrate that the proposed method is able to significantly improve the quality of enhanced frames in terms of both objective and subjective criterions.
Modular design and initial gait study of an amphibian robotic turtle (2007)

As another kind of the biomimetic underwater vehicles, a biologically inspired robotic turtle is studied and modeled. The modular design philosophy and construction of the prototype after a family of sea turtle - Cheloniidae is discussed. The dual-purpose robotic turtle is designed to imitate locomotion behaviors of Cheloniidae, both in water and on the land to achieve amphibian operations. Our motivation is to improve the design and performance of amphibian vehicles, which will have the reasonable speed and stable swimming ability like turtles. Studies have shown the high effectiveness of the turtle’s underwater locomotion, whose thrust generated by the flapping foil-like flippers. The crawling and lift-based swimming gaits are analyzed and implemented on the prototype. The platform is being developed for the testing to be conducted in outdoor real environment.
Design and analysis of dynamic Huffman codes (1987)

A new one-pass algorithm for constructing dynamic Huffman codes is introduced and analyzed. We also analyze the one-pass algorithm due to Faller, Gallager, and Knuth. In each algorithm, both the sender and the receiver maintain equivalent dynamically varying Huffman trees, and the coding is done in real time. We show that the number of bits used by the new algorithm to encode a message containing t letters is < t bits more than that used by the conventional two-pass Huffman scheme, independent of the alphabet size. This is best possible in the worst case, for any one-pass Huffman method. Tight upper and lower bounds are derived. Empirical tests show that the encodings produced by the new algorithm are shorter than those of the other one-pass algorithm and, except for long messages, are shorter than those of the two-pass method. The new algorithm is well suited for on-line encoding/decoding in data networks and for tile compression.
Multiplex PCR Assay for Detection of Bacterial Pathogens Associated with Warm-Water Streptococcosis in Fish (2004)

A multiplex PCR-based method was designed for the simultaneous detection of the main pathogens involved in warm-water streptococcosis in fish (Streptococcus iniae, Streptococcus difficilis, Streptococcus parauberis, and Lactococcus garvieae). Each of the four pairs of oligonucleotide primers exclusively amplified the targeted gene of the specific microorganism. The sensitivity of the multiplex PCR using purified DNA was 25 pg for S. iniae, 12.5 pg for S. difficilis, 50 pg for S. parauberis, and 30 pg for L. garvieae. The multiplex PCR assay was useful for the specific detection of the four species of bacteria not only in pure culture but also in inoculated fish tissue homogenates and naturally infected fish. Therefore, this method could be a useful alternative to the culture-based method for the routine diagnosis of warm-water streptococcal infections in fish.
A High Precision Standard of Frequency<sup>1</sup> (1929)

A new standard of frequency is described in which three 100,000 cycle quartz crystal-controlled oscillators of very high constancy are employed. These are interchecked automatically and continuously with a precision of about one part in one hundred million. They are checked daily in terms of radio time signals by the usual method employing a clock controlled by current maintained at a submultiple of the crystal frequency. Specially shaped crystals are used which have been adjusted to have temperature coefficients less than 0.0001 per cent per degree C.
Biodegradable microparticles and fiber fabrics for sustained delivery of cisplatin to treat C6 glioma <i>in vitro</i> (2007)

The duration of cisplatin release from most of the drug delivery devices seemed to be shorter than 14 days except large microparticles. The objective of this study was to fabricate and characterize cisplatin-loaded PLA microparticles, PLA/PLGA (30/70) composite microparticles, and fibers as formulations for long-term sustained delivery of cisplatin to treat C6 glioma in vitro by electrospray and electrospinning techniques. Cisplatin-loaded biodegradable microparticles with particle size of around 5 microm and fiber fabrics with diameter of 0.5-1.7 microm were obtained using electrospray and electrospinning techniques. Encapsulation efficiency and in vitro release of formulations were measured by ICP-OES. The encapsulation efficiency for different samples of microparticles was approximately from 33% to 72% and the fiber fabrics had encapsulation efficiency greater than 90%. Cisplatin-loaded microparticles showed typical characteristics of cisplatin release profile: a large initial burst followed by a sustained slow release of 35 days. The composite PLA/PLGA (30/70) microparticles could reduce the initial burst release of cisplatin because of their core-shell structures. In contrast, more than 75 days sustained release could be achieved by fiber fabric formulations without large initial burst. MTT assay was used to quantify the cytotoxicity of different formulations against C6 glioma cells. Microparticle formulations had slightly higher cytotoxicity than free drug. In contrast, the cytotoxicity of fiber fabrics formulation was around 4 times higher than of the free drug based on the actual amount of drug released. The microparticle and fiber fabric formulations presented may be promising for the sustained delivery of cisplatin to eliminate the undesired side effects caused by direct injection of cisplatin solution in systemic administration.
Pharmacokinetics of intravitreally injected liposome-encapsulated tobramycin in normal rabbits (1990)

Bacterial endophthalmitis, which is a devastating complication of intraocular surgery or eye trauma, has a poor prognosis. Intravitreal injection of antimicrobial agents has become a part of the standard treatment of endophthalmitis. The authors investigate the pharmacokinetics of intravitreal liposome-encapsulated tobramycin as a possible method of prolonging the duration of therapeutic concentrations. Tobramycin was encapsulated into liposomes of phosphatidylcholine, phosphatidic acid, and alpha-tocopherol by the reverse phase evaporation method. The final liposomal suspension contained tobramycin, 7.0 mg/ml, 60.5% encapsulated. One eye received an intravitreal injection of either liposome-encapsulated tobramycin (LET), tobramycin phosphated-buffered saline (TS) or a mixture of tobramycin and liposome-encapsulated saline (TEL), and the results were as follows: 1. Concentrations of free tobramycin were significantly lower with LET than with TS or TEL at 1 hour after intravitreal injection. 2. Concentrations of free and total tobramycin were significantly higher with LET than with TS or TEL at 5 and 8 days after intravitreal injection. Concentrations of free tobramycin with TS were lower than the minimal inhibitory concentration(MIC) of tobramycin for Pseudomonas aeruginosa at 8 days after intravitreal injection, while those with LET were higher than the MIC of tobramycin for Pseudomonas aeruginosa 18 days after injection.