gebhart/patrepeval huggingface dataset:
Requirement for Distal Upstream Sequences for Maximal Transcription In Vitro of Early Region IV of Adenovirus (1984)

A series of deletion mutants spanning the adenovirus early region IV (EIV) promoter were tested for transcription activity in vitro. At least three elements were found to be important for maximal transcription in HeLa whole-cell extracts. Deletion of the TATA box drastically reduced the transcription activity from the EIV promoter. Sequences between nucleotides -58 and -44 are also important for efficient transcription since deletion of this region reduced activity by 50%. More importantly, sequences residing upstream from -140 critically influence the level of EIV transcription. Deletion of sequences between nucleotides -325 (the right terminus of adenovirus genome) and -140 reduced the level of transcription more than 10-fold. It is possible that a specific cellular factor stimulates EIV transcription by recognition of these upstream sequences. The dependence of transcription from the EIV promoter on a distal upstream element may explain some aspects of the regulation of this promoter.
Improving empiric antibiotic selection using computer decision support (1994)

<h3>Background:</h3> Physicians frequently need to start antibiotic therapy before the results of bacterial cultures and antibiotic susceptibility tests are available. We developed and evaluated a computerized antibiotic consultant to assist physicians in the selection of appropriate empiric antibiotics. <h3>Methods:</h3> We used a two-stage random-selection study to compare antibiotics suggested by the antibiotic consultant with 482 associated antibiotic susceptibility results and the concurrent antibiotics ordered by physicians. The antibiotics ordered by randomized physicians were then compared between crossover periods of antibiotic consultant use. <h3>Results:</h3> The antibiotic consultant suggested an antibiotic regimen to which all isolated pathogens were shown to be susceptible for 453 (94%) of 482 culture results, while physicians ordered an antibiotic regimen to which all isolated pathogens were susceptible for 369 culture results (77%) (<i>P</i><.001). The physicians who prescribed antibiotics to which all pathogens were susceptible did so a mean of 21 hours after the culture specimens were collected. Physicians ordered appropriate antibiotics within 12 hours of the culture collection significantly more often when they had use of the antibiotic consultant than during the period before use (<i>P</i><.035). Moreover, 88% of the physicians stated they would recommend the program to other physicians, 85% said the program improved their antibiotic selection, and 81% said they felt use of the program improved patient care. <h3>Conclusions:</h3> Information from computer-based medical records can be used to help improve physicians' selection of empiric antibiotics for infections. (Arch Intern Med. 1994;154:878-884)
JAutomate: A Tool for System- and Acceptance-test Automation (2013)

System- and acceptance-testing are primarily performed with manual practices in current software industry. However, these practices have several issues, e.g. they are tedious, error prone and time consuming with costs up towards 40 percent of the total development cost. Automated test techniques have been proposed as a solution to mitigate these issues, but they generally approach testing from a lower level of system abstraction, leaving a gap for a flexible, high system-level test automation technique/tool. In this paper we present JAutomate, a Visual GUI Testing (VGT) tool that fills this gap by combining image recognition with record and replay functionality for high system-level test automation performed through the system under test's graphical user interface. We present the tool, its benefits compared to other similar techniques and manual testing. In addition, we compare JAutomate with two other VGT tools based on their static properties. Finally, we present the results from a survey with industrial practitioners that identifies test-related problems that industry is currently facing and discuss how JAutomate can solve or mitigate these problems.
Damping of Underwater Explosion Bubble Oscillations (1956)

When an explosive detonates underwater it creates a bubble of gas which performs damped radial oscillations of large amplitude. The usual theory of these oscillations treats the water as incompressible and yields undamped oscillations of constant period. We have modified this theory by taking account of the compressibility of the water. Our theory predicts damped oscillations of diminishing period. Comparison of the predicted and observed radius-time curves for one particular case shows fairly good agreement. Radius-time curves for four representative cases have been computed with a large number of periods in each case. These can be used to describe a variety of explosions.
Fractal analysis of permeabilities for porous media (2004)

Abstract A fractal analysis of permeabilities for porous media, both saturated and unsaturated, is presented based on the fractal nature of pores in the media. Both the fractal‐phase permeability and the fractal relative permeability are derived and found to be a function of the tortuosity fractal dimension, pore‐area fractal dimension, phase fractal dimension, saturation, and microstructural parameters. The proposed models for permeabilities—both the phase permeability and the relative permeability—do not contain any empirical constant. The validity of the present analysis is verified by a comparison with the existing measurements, and excellent agreement between the model predictions and experimental data is found. In addition, the present work reveals that the relative permeability depends not only on saturation but also on the two fractal dimensions, pore fractal dimension (at porosity greater than 0.90), and tortuosity fractal dimension, which characterize the fractal characters of capillaries in porous media. The two fractal dimensions may be the two of the important mechanisms affecting the relative permeability in porous media, and this is a supplement to the available conclusion on relative permeability. © 2004 American Institute of Chemical Engineers AIChE J, 50: 46–57, 2004
Level set and fast marching methods in image processing and computer vision (2002)

Level set methods have been used in a variety of settings for problems in computer vision and image processing. A related numerical methodology, known as "fast marching methods", has been developed to solve static Hamilton-Jacobi equations extremely quickly; the techniques rely on conversion to a static problem, and are based on a marriage between narrow band techniques for level set methods and fast sorting algorithms. We show the application of these techniques to a collection of problems, including image denoising and enhancement schemes based on curvature-controlled diffusion with automatic stopping and hierarchical scales, extremely fast shape-from-shading schemes, and shape recovery in medical imaging. Level set methods have also been applied to problems in image denoising and enhancement through curvature-controlled diffusion schemes. An extension of these techniques, known as fast marching methods, has been developed to solve static Hamilton-Jacobi equations which arise in aspects of computer vision. We discuss advances in both of these techniques for such problems.
Hepcidin, iron status, and renal function in chronic renal failure, kidney transplantation, and hemodialysis (2006)

Hepcidin is a small defensin-like peptide whose production by hepatocytes is modulated in response to anemia, hypoxia, or inflammation. Hepcidin could also act as an indicator of functional iron deficiency in these patients. Cross-sectional study was performed to assess hepcidin correlations with renal function, iron status, and hsCRP in patients with chronic renal failure on conservative treatment, on hemodialyses, and in kidney transplant recipients. Iron status, complete blood count, creatinine, albumin, lipids were assessed using standard laboratory methods. GFR was estimated using MDRD formula. Hepcidin and high sensitivity CRP were measured using commercially available kits. Ferritin and hepcidin were higher in hemodialyzed patients, kidney transplant recipients, and patients with chronic renal failure over controls. In patients with chronic renal failure, hepcidin correlated significantly with total protein, albumin, creatinine, and eGRF. In kidney transplant recipients, hepcidin correlated significantly in univariate analysis, with total protein, ferritin, time after transplantation, creatinine, eGRF and tended to correlate with cholesterol. In hemodialyzed patients hepcidin, correlated significantly with triglycerides, albumin, creatinine, urea, residual renal function, and hsCRP. In healthy volunteers, hepcidin was related to triglycerides and ferritin. Multiple regression analysis in hemodialyzed patients showed that hepcidin was independently related to creatinine, triglycerides, and residual renal function. Multiple regression analysis in kidney transplant recipients showed that hepcidin was independently related only to GFR and ferritin. Elevated hepcidin in all groups of patients studied may be due to low grade inflammation, frequently encountered in this population and mainly to impaired renal function.
Diabetes mellitus does not adversely affect outcomes from a critical illness* (2009)

Critically ill adults with DM do not have an increased mortality compared with that seen in patients without DM, and may have a decreased mortality. Further investigation needs to be done to determine the mechanism for this effect.
Consumer attitudes toward counterfeits: a review and extension (2007)

Purpose The purpose of this research is to propose and test a model that integrates the main predictors of consumers' attitude and behavioral intentions toward counterfeits; to help companies understand the main factors influencing consumer behavior toward counterfeits and create effective anti‐piracy strategies. Design/methodology/approach An integrated model is proposed following the studies by Ang et al. and Huang et al. A survey with 400 consumers was conducted in the Brazilian market and the Structural Equation Modeling technique was used to test the hypothesized relationships. Findings The main contribution of the paper is to show that consumer intentions to buy counterfeited products are dependent on the attitudes they have toward counterfeits, which in turn are more influenced by perceived risk, whether consumers have bought a counterfeit before, subjective norm, integrity, price‐quality inference and personal gratification. The paper reinforces the mediator role of attitude in the relationship between these antecedents and behavioral intentions. Moreover, previous experience with counterfeits consumption does not have a direct effect on behavioral intentions, but only an indirect effect through attitude. Practical implications The paper contributes to inform policy makers and managers of brands about the main predictors of consumer's attitudes toward counterfeits. In this way, ads intended to discourage consumption of counterfeits could use the perceived risk as the main message appeal. Originality/value This paper investigates the key antecedents and consequences of consumer attitudes toward counterfeits by integrating and testing two recent models dealing with this subject in the marketing literature.
Biosynthesis, Glycosylation, and Enzymatic Processingin Vivo of Human Tripeptidyl-peptidase I (2003)

Human tripeptidyl-peptidase I (TPP I, CLN2 protein) is a lysosomal serine protease that removes tripeptides from the free N termini of small polypeptides and also shows a minor endoprotease activity. Due to various naturally occurring mutations, an inherited deficiency of TPP I activity causes a fatal lysosomal storage disorder, classic late infantile neuronal ceroid lipofuscinosis (CLN2). In the present study, we analyzed biosynthesis, glycosylation, transport, and proteolytic processing of this enzyme in stably transfected Chinese hamster ovary cells as well as maturation of the endocytosed proenzyme in CLN2 lymphoblasts, fibroblasts, and N2a cells. Human TPP I was initially identified as a single precursor polypeptide of approximately 68 kDa, which, within a few hours, was converted to the mature enzyme of approximately 48 kDa. Compounds affecting the pH of intracellular acidic compartments, those interfering with the intracellular vesicular transport as well as inhibition of the fusion between late endosomes and lysosomes by temperature block or 3-methyladenine, hampered the conversion of TPP I proenzyme into the mature form, suggesting that this process takes place in lysosomal compartments. Digestion of immunoprecipitated TPP I proenzyme with both N-glycosidase F and endoglycosidase H as well as treatment of the cells with tunicamycin reduced the molecular mass of TPP I proenzyme by approximately 10 kDa, which indicates that all five potential N-glycosylation sites in TPP I are utilized. Mature TPP I was found to be partially resistant to endo H treatment; thus, some of its N-linked oligosaccharides are of the complex/hybrid type. Analysis of the effect of various classes of protease inhibitors and mutation of the active site Ser(475) on human TPP I maturation in cultured cells demonstrated that although TPP I zymogen is capable of autoactivation in vitro, a serine protease that is sensitive to AEBSF participates in processing of the proenzyme to the mature, active form in vivo.
A study for the optical wireless module based on IEEE1394 (2000)

We are currently developing a 125 Mbps optical wireless module for a proposed infrared-based IEEE1394/S100 system. So as to avoid the effect of reflections, the module is implemented using IEEE1394 arbitration for a half-duplex optical link between the transmitter and receiver. One possibility is to develop a compact module for future use in handheld equipment.
Evaluation of Sasobit® for Use in Warm Mix Asphalt (2005)

Several new processes have been developed to reduce the mixing and compaction temperatures of hot mix asphalt without sacrificing the quality of the resulting pavement. One of these processes utilizes Sasobit®, a synthetic long chain Fischer-Tropsch wax. Sasobit® can be blended with the binder at a terminal or in the contractor’s tank, introduced in a molten form, added with the aggregate, or pneumatically blown into a drum plant. A laboratory study was conducted to determine the applicability of Sasobit® to typical paving operations and environmental conditions commonly found in the United States, including the performance of the mixes in quick traffic turn-over situations and high temperature conditions. Superpave gyratory compactor (SGC) results indicated that Sasobit® may lower the optimum asphalt content, so it should be added during the mix design process. Sasobit® was shown to improve the compactability of mixtures in both the SGC and vibratory compactor. Statistics indicated an overall reduction in air voids. Improved compaction was noted at temperatures as low as 190°F (88°C). The addition of Sasobit® does not affect the resilient modulus of an asphalt mix nor does it increase the rutting potential of an asphalt mix as measured by the Asphalt Pavement Analyzer. The rutting potential did increase with decreasing mixing and compaction temperatures, which may be related to the decreased aging of the binder resulting from the lower temperatures as well as from the anti-aging properties of Sasobit. There was no evidence of differing strength gain with time for the mixes containing Sasobit® as compared to the control mixes indicating that a prolonged cure time before opening to traffic is not an issue. The lower compaction temperature used when producing warm asphalt with Sasobit® or any such similar Warm Mix additive may increase the potential for moisture damage. Overall, Sasobit® appears to be a viable tool for reducing mixing and compaction temperatures that can be readily added to hot mix asphalt. Reductions in mixing and compaction temperatures are expected to reduce fuel costs, reduce emissions, widen the winter paving window, and facilitate specialized applications, such as airport runway construction, where rapid opening to traffic is essential.
Blurriness-guided unsharp masking (2017)

It has been observed that enhancing a highly-blurred image region could often lead to unpleasant noise amplification. Motivated by this, an adaptive unsharp masking (UM) method is proposed in this paper, which incorporates the estimated local blurriness information into the enhancement process to adaptively determine the scaling factor for each pixel on the detail layer. To achieve this goal, a pixel-wise local blurriness estimation method is developed for generating a pixel-wise blurriness map, followed by individually converting each blurriness measurement on the map to a scaling factor via a mapping process. The proposed method not only avoids noise amplification in blurred regions but also addresses `high-level' considerations, such as photographer's original intention on making background more blurred for creating special aesthetic effect. Extensive simulations conducted on various test images have demonstrated that our approach is able to deliver much superior perceptual quality of enhanced images compared to other state-of-the-art UM methods.
Normally on GaAs/AlAs multiple-quantum well Fabry–Perot transmission modulator with ON/OFF contrast ratios ≳7.4 (1995)

A normal-incident normally on GaAs/AlAs multiple-quantum well Fabry–Perot transmission modulator is reported. The fabricated modulator achieves ON/OFF transmittance changes larger than 30% and ON/OFF contrast ratios larger than 7.4 at the wavelength of 842.5 nm with a reverse bias voltage of 9 V.
1-μs laser pulses from XeF (1977)

Long-pulse operation of the XeF laser has been achieved utilizing electron beam excitation of Ar/Xe/NF3 gas mixtures. For a total mixture pressure of 2.5 atm, ∼0.30 J of 350-nm radiation was obtained in a 1-μs FWHM pulse.
Some Analogs of 1-p-Chlorobenzyl-5-methylindole-3-acetic Acid. (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Analogs of 1-p-Chlorobenzyl-5-methylindole-3-acetic Acid.Edward Walton, Susan Jenkins, Ruth Nutt, and Frederick HollyCite this: J. Med. Chem. 1968, 11, 6, 1252–1255Publication Date (Print):November 1, 1968Publication History Published online20 September 2004Published inissue 1 November 1968https://pubs.acs.org/doi/10.1021/jm00312a605https://doi.org/10.1021/jm00312a605research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Perspectives of Comprehensive Phosphoproteome Analysis Using Shotgun Strategy (2011)

Protein phosphorylation is a ubiquitous post-translational modification that regulates almost all cellular processes. The analysis of protein phosphorylation is challenging due to the high dynamic range and low abundance natures of the analyte. Shotgun based proteomics has emerged as a very useful platform to achieve a comprehensive phosphoproteome analysis in considerable depth. In the past few years, significant breakthroughs on the large scale phosphorylation analysis have been witnessed along with the great development of related technologies. The combination of effective enrichment materials, refined analysis workflows, new type of powerful mass spectrometers, and sophisticated bioinformatic tools greatly boost the performance of comprehensive phosphoproteome analysis. In this Perspective, we briefly reviewed recent technological developments on the enrichment materials, prefractionation workflows, and different mass spectrometry fragmentation modes as well as software tools for phosphoproteome identification and quantification. Then, we described the current challenges and potential directions for the future of comprehensive phosphoproteome analysis. We also provide perspectives on how to further improve the performance of related analysis methods and technologies.
Production of <i>Haemophilus influenzae</i> b Meningitis in Infant Rats by Intraperitoneal Inoculation (1973)

Sprague-Dawley rats have a marked age-related susceptibility to Haemophilus influenzae type b that does not correlate with serum bactericidal activity. Eighty percent of 5-day-old animals that survive to 48 h after an intraperitoneal inoculation of a mean lethal dose of bacteria have histologically documented meningitis. Animals surviving the inoculations as infants manifest cerebral dysfunction as adults. This model should facilitate experimental study of bacterial meningitis.
2-Ene-1,4-diols by Dimerization of Terminal Epoxides using Hindered Lithium Amides (2005)

[reaction: see text] Reaction of hindered lithium amides with readily available (enantiopure) terminal epoxides gives 2-ene-1,4-diols via carbenoid dimerization of the corresponding alpha-lithiated epoxides. D-Mannitol and D-iditol were synthesized using this method in three steps from (S)-tritylglycidyl ether.
Increased risk of varicella-zoster virus infection in patients with breast cancer after adjuvant radiotherapy: A population-based cohort study (2019)

Radiotherapy was associated with an increased risk of VZV infection among patients with breast cancer. The risk was significantly higher in older patient (>65 years old) and/or those who received chemotherapy. Regular clinical follow-up and additional serological testing in the first 5 months after radiotherapy are recommended.
Characteristics analysis of wavelength-division-multiplexing fiber couplers fabricated with a microheater (1996)

Optical properties and taper profiles of 1.3l/l.55-µm wavelength-division-multiplexing (WDM) fiber couplers have been experimentally analyzed. A newly developed microheater was used for the fabrication in air. The elongation lengths were controlled so that the fourth coupling peak would reach the 1.55-µm wavelength. The wavelength difference Δλ between the peak coupling wavelength of 1.55 µm and that around 1.31 µm decreased linearly at each fusion temperature with the fusion time. At each fusion temperature, the Δλ value decreased linearly with the elongation length and decreased exponentially with the neck width. The Δλ value and the taper shape at the minimum limit of the degree of fusion were estimated. The fabrication condition and the taper shape for 1.31-µm and 1.55-µm WDM coupling were also analyzed.