gebhart/patrepeval huggingface dataset:
Blockade of Programmed Death-1 in Young (New Zealand Black × New Zealand White)F1 Mice Promotes the Suppressive Capacity of CD4+ Regulatory T Cells Protecting from Lupus-like Disease (2013)

Programmed death-1 (PD-1) usually acts as a negative signal for T cell activation, and its expression on CD8(+)Foxp3(+) T cells is required for their suppressive capacity. In this study, we show that PD-1 signaling is required for the maintenance of functional regulatory CD4(+)CD25(+)Foxp3(+) regulatory T cells (CD4(+) T(reg)) that can control autoimmunity in (New Zealand Black × New Zealand White)F1 lupus mice. PD-1 signaling induced resistance to apoptosis and prolonged the survival of CD4(+) T(reg). In vivo, the blockade of PD-1 with a neutralizing Ab reduced PD-1 expression on CD4(+) T(reg) (PD1(lo)CD4(+) T(reg)). PD1(lo)CD4(+) T(reg) had an increased ability to promote B cell apoptosis and to suppress CD4(+) Th as compared with CD4(+) T(reg) with elevated PD-1 expression (PD1(hi)CD4(+) T(reg)). When PD-1 expression on CD4(+) T(reg) was blocked in vitro, PD1(lo)CD4(+) T(reg) suppressed B cell production of IgG and anti-dsDNA Ab. Finally, in vitro studies showed that the suppressive capacity of CD4(+) T(reg) depended on PD-1 expression and that a fine-tuning of the expression of this molecule directly affected cell survival and immune suppression. These results indicate that PD-1 expression has multiple effects on different immune cells that directly contribute to a modulation of autoimmune responses.
Phase I and II pharmacokinetic and pharmacodynamic study of the proteasome inhibitor bortezomib in Japanese patients with relapsed or refractory multiple myeloma (2007)

The purpose of this phase I and II study was to evaluate the safety, pharmacokinetics, pharmacodynamics, and efficacy of bortezomib in Japanese patients with relapsed or refractory multiple myeloma. This was a dose-escalation study designed to determine the recommended dose for Japanese patients (phase I) and to investigate the antitumor activity and safety (phase II) of bortezomib administered on days 1, 4, 8, and 11 every 21 days. Thirty-four patients were enrolled. A dose-limiting toxicity was febrile neutropenia, which occurred in one of six patients in the highest-dose cohort in phase I and led to the selection of 1.3 mg/m(2) as the recommended dose. Adverse events >or= grade 3 were rare except for hematological toxicities, although there was one fatal case of interstitial lung disease. The overall response rate was 30% (95% confidence interval, 16-49%). Pharmacokinetic evaluation showed a biexponential decline, characterized by a rapid distribution followed by a longer elimination, after dose administration, whereas the area under the concentration-time curve increased proportionately with the dose. Bortezomib was effective in Japanese patients with relapsed or refractory multiple myeloma. A favorable tolerability profile was also seen, although the potential for pulmonary toxicity should be monitored closely. The pharmacokinetic and pharmacodynamic profiles of bortezomib in the present study warrant further investigations, including more relevant administration schedules.
AIRS near-real-time products and algorithms in support of operational numerical weather prediction (2003)

The assimilation of Atmospheric InfraRed Sounder, Advanced Microwave Sounding Unit-A, and Humidity Sounder for Brazil (AIRS/AMSU/HSB) data by Numerical Weather Prediction (NWP) centers is expected to result in improved forecasts. Specially tailored radiance and retrieval products derived from AIRS/AMSU/HSB data are being prepared for NWP centers. There are two types of products - thinned radiance data and full-resolution retrieval products of atmospheric and surface parameters. The radiances are thinned because of limitations in communication bandwidth and computational resources at NWP centers. There are two types of thinning: (1) spatial and spectral thinning and (2) data compression using principal component analysis (PCA). PCA is also used for quality control and for deriving the retrieval first guess used in the AIRS processing software. Results show that PCA is effective in estimating and filtering instrument noise. The PCA regression retrievals show layer mean temperature (1 km in troposphere, 3 km in stratosphere) accuracies of better than 1 K in most atmospheric regions from simulated AIRS data. Moisture errors are generally less than 15% in 2-km layers, and ozone errors are near 10% over approximately 5-km layers from simulation. The PCA and regression methodologies are described. The radiance products also include clear field-of-view (FOV) indicators. The residual cloud amount, based on simulated data, for FOVs estimated to be clear (free of clouds) is about 0.5% over ocean and 2.5% over land.
Learning by Cheating (2019)

Vision-based urban driving is hard. The autonomous system needs to learn to perceive the world and act in it. We show that this challenging learning problem can be simplified by decomposing it into two stages. We first train an agent that has access to privileged information. This privileged agent cheats by observing the ground-truth layout of the environment and the positions of all traffic participants. In the second stage, the privileged agent acts as a teacher that trains a purely vision-based sensorimotor agent. The resulting sensorimotor agent does not have access to any privileged information and does not cheat. This two-stage training procedure is counter-intuitive at first, but has a number of important advantages that we analyze and empirically demonstrate. We use the presented approach to train a vision-based autonomous driving system that substantially outperforms the state of the art on the CARLA benchmark and the recent NoCrash benchmark. Our approach achieves, for the first time, 100% success rate on all tasks in the original CARLA benchmark, sets a new record on the NoCrash benchmark, and reduces the frequency of infractions by an order of magnitude compared to the prior state of the art. For the video that summarizes this work, see https://youtu.be/u9ZCxxD-UUw
Tertiary Amines from Methiodides and Lithium Aluminum Hydride<sup>1</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTertiary Amines from Methiodides and Lithium Aluminum Hydride1Arthur C. Cope, Engelbert Ciganek, Lee J. Fleckenstein, and Melvin A. P. MeisingerCite this: J. Am. Chem. Soc. 1960, 82, 17, 4651–4655Publication Date (Print):September 1, 1960Publication History Published online1 May 2002Published inissue 1 September 1960https://doi.org/10.1021/ja01502a051RIGHTS & PERMISSIONSArticle Views425Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (711 KB) Get e-Alerts Get e-Alerts
An Irish three-generation family of Cornelia de Lange syndrome displaying autosomal dominant inheritance (2003)

The existence of familial de Lange syndrome has been documented in sibs and in parent-child families, but the inheritance pattern continues to be the cause of much debate. We describe a classically affected neonate with de Lange syndrome, an affected mother and probably affected maternal grandmother. These cases show evidence for a dominantly inherited syndrome with a de Lange phenotype.
Direct determination of trace mercury and cadmium in food by sequential electrothermal vaporization atomic fluorescence spectrometry using tungsten and gold coil traps (2018)

On the basis of vaporization temperature difference, a novel solid sampling AFS was developed for the sequential determination of trace Hg and Cd in food samples.
Osmotic stress–induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p (2002)

Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P(2)) was first identified as a non-abundant phospholipid whose levels increase in response to osmotic stress. In yeast, Fab1p catalyzes formation of PtdIns(3,5)P(2) via phosphorylation of PtdIns(3)P. We have identified Vac14p, a novel vacuolar protein that regulates PtdIns(3,5)P(2) synthesis by modulating Fab1p activity in both the absence and presence of osmotic stress. We find that PtdIns(3)P levels are also elevated in response to osmotic stress, yet, only the elevation of PtdIns(3,5)P(2) levels are regulated by Vac14p. Under basal conditions the levels of PtdIns(3,5)P(2) are 18-28-fold lower than the levels of PtdIns(3)P, PtdIns(4)P, and PtdIns(4,5)P(2). After a 10 min exposure to hyperosmotic stress the levels of PtdIns(3,5)P(2) rise 20-fold, bringing it to a cellular concentration that is similar to the other phosphoinositides. This suggests that PtdIns(3,5)P(2) plays a major role in osmotic stress, perhaps via regulation of vacuolar volume. In fact, during hyperosmotic stress the vacuole morphology of wild-type cells changes dramatically, to smaller, more highly fragmented vacuoles, whereas mutants unable to synthesize PtdIns(3,5)P(2) continue to maintain a single large vacuole. These findings demonstrate that Vac14p regulates the levels of PtdIns(3,5)P(2) and provide insight into why PtdIns(3,5)P(2) levels rise in response to osmotic stress.
Antibiotic Treatment Alters the Colonic Mucus Layer and Predisposes the Host to Exacerbated <i>Citrobacter rodentium</i> -Induced Colitis (2011)

Antibiotics are often used in the clinic to treat bacterial infections, but the effects of these drugs on microbiota composition and on intestinal immunity are poorly understood. Citrobacter rodentium was used as a model enteric pathogen to investigate the effect of microbial perturbation on intestinal barriers and susceptibility to colitis. Streptomycin and metronidazole were used to induce alterations in the composition of the microbiota prior to infection with C. rodentium. Metronidazole pretreatment increased susceptibility to C. rodentium-induced colitis over that of untreated and streptomycin-pretreated mice, 6 days postinfection. Both antibiotic treatments altered microbial composition, without affecting total numbers, but metronidazole treatment resulted in a more dramatic change, including a reduced population of Porphyromonadaceae and increased numbers of lactobacilli. Disruption of the microbiota with metronidazole, but not streptomycin treatment, resulted in an increased inflammatory tone of the intestine characterized by increased bacterial stimulation of the epithelium, altered goblet cell function, and thinning of the inner mucus layer, suggesting a weakened mucosal barrier. This reduction in mucus thickness correlates with increased attachment of C. rodentium to the intestinal epithelium, contributing to the exacerbated severity of C. rodentium-induced colitis in metronidazole-pretreated mice. These results suggest that antibiotic perturbation of the microbiota can disrupt intestinal homeostasis and the integrity of intestinal defenses, which protect against invading pathogens and intestinal inflammation.
Use of Transesophageal Echocardiography to Guide Cardioversion in Patients with Atrial Fibrillation (2001)

The use of transesophageal echocardiography to guide the management of atrial fibrillation may be considered a clinically effective alternative strategy to conventional therapy for patients in whom elective cardioversion is planned.
Ritual Significance in Mycenaean Hairstyles (2012)

Although the frescoes excavated from Bronze Age sites on the Greek mainland provide evidence for female figures in the Mycenaean society, the hairstyles of these figures have not been studied in detail. As in many other ancient cultures, hairstyles were not only an exhibition of beauty and fashion, but they also represented certain age groups or a person’s social status. The Mycenaeans inherited many of their hairstyles from their Minoan predecessors, although differences existed as well. It is also possible there may have been a shift in meaning for seemingly similar looking hairstyles from the Minoan to the Mycenaean periods. Female figures, which compose most of the Mycenaean figures in frescoes known to date, are fine examples for discussing the artistic representation and potential significance of Mycenaean hairstyles. By comparing with Minoan hairstyles, discussions of Mycenaean examples lead to conclusions in the relationship between hairstyles and ritual activities in the Mycenaean society.
Novel Neurotransmitters and Their Neuropsychiatric Relevance (2000)

The diversity of novel neurotransmitters and venues of their activity afford multiple opportunities for therapeutic intervention.
Automation of Electrical Cable Harnesses Testing (2017)

Traditional automated systems, such as industrial robots, are applied in well-structured environments, and many automated systems have a limited adaptability to deal with complexity and uncertainty; therefore, the applications of industrial robots in small- and medium-sized enterprises (SMEs) are very limited. The majority of manual operations in SMEs are too complicated for automation. The rapidly developed information technologies (IT) has brought new opportunities for the automation of manufacturing and assembly processes in the ill-structured environments. Note that an automation solution should be designed to meet the given requirements of the specified application, and it differs from one application to another. In this paper, we look into the feasibility of automated testing for electric cable harnesses, and our focus is on some of the generic strategies for the improvement of the adaptability of automation solutions. Especially, the concept of modularization is adopted in developing hardware and software to maximize system adaptability in testing a wide scope of products. A proposed system has been implemented, and the system performances have been evaluated by executing tests on actual products. The testing experiments have shown that the automated system outperformed manual operations greatly in terms of cost-saving, productivity and reliability. Due to the potential of increasing system adaptability and cost reduction, the presented work has its theoretical and practical significance for an extension for other automation solutions in SMEs.
Measurement-Based Self Organization of Interfering 802.11 Wireless Access Networks (2007)

The popularity of IEEE 802.11 WLANs has led to dense deployments in urban areas. High density leads to sub-optimal performance unless the interfering networks learn how to optimally use and share the spectrum. This paper proposes two fully distributed algorithms that allow (i) multiple interfering 802.11 access points to select their operating frequency in order to minimize interference, and (ii) users to choose the access point they attach to, in order to get their fair share of the whole network bandwidth. The proposed algorithms rely on Gibbs sampler, and do not require explicit coordination among the wireless devices. They only require the participating wireless nodes to measure local quantities such as interference and transmission delay. The algorithms are shown to lead to optimal bandwidth sharing, where optimality is defined according to the minimal potential delay. We analytically prove the convergence of the proposed algorithms, and study their performance by simulation.
Effect of magnetic polaritons on the radiative properties of double-layer nanoslit arrays (2010)

Recent studies show that magnetic polaritons (MPs) are responsible for the extraordinary optical transmission in subwavelength periodic structures. However, the role of MP in double-layer nanoslit arrays has not been fully understood. This paper elucidates how MPs influence the radiative properties of nanoslit arrays at both normal and oblique incidences using the rigorous coupled-wave analysis. The existence of MPs is further confirmed by an equivalent LC circuit model. The effects of geometric parameters and lateral displacement on the resonance conditions are also investigated, and possible ways of tailoring the radiative properties of nanostructures for energy-harvesting applications are suggested.
Cell-Cycle-Dependent Pharmacology of Methotrexate in HL-60 (2005)

The role of the susceptibility of cells and the pharmacokinetics of MTX on the time-dependent change of methotrexate (MTX) pharmacologic action in HL-60 (human leukemia cell) was investigated from the viewpoints of the rhythm of DNA synthesis. The highest activity of MTX was observed at the time when DNA synthesis, dihydrofolate reductase (DHFR) activity, DHFR content, and DHFR mRNA content increased and the lowest activity was observed at the time when they decreased. There were significant time-dependent changes in MTX efflux. The result corresponded to the rhythm in MTX activity. The present study suggests that the time-dependent change of MTX activity is caused by a change in the sensitivity of cells and the pharmacokinetics of the drug. Therefore, the choice of dosing time associated with cell rhythmicity may help to achieve rational chronotherapeutics, increasing therapeutic effects.
One Reality (2017)

Most of our daily activities take place in the physical world, which inherently imposes physical constraints. In contrast, the digital world is very flexible, but usually isolated from its physical counterpart. To combine these two realms, many Mixed Reality (MR) techniques have been explored, at different levels in the continuum. In this work we present an integrated Mixed Reality ecosystem that allows users to incrementally transition from pure physical to pure virtual experiences in a unique reality. This system stands on a conceptual framework composed of 6 levels. This paper presents these levels as well as the related interaction techniques.
GM-CSF–deficient mice are susceptible to pulmonary group B streptococcal infection (1999)

Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-targeted mice (GM-/-) cleared group B streptococcus (GBS) from the lungs more slowly than wild-type mice. Expression of GM-CSF in the respiratory epithelium of GM-/- mice improved bacterial clearance to levels greater than that in wild-type GM+/+ mice. Acute aerosolization of GM-CSF to GM+/+ mice significantly enhanced clearance of GBS at 24 hours. GBS infection was associated with increased neutrophilic infiltration in lungs of GM-/- mice, while macrophage infiltrates predominated in wild-type mice, suggesting an abnormality in macrophage clearance of bacteria in the absence of GM-CSF. While phagocytosis of GBS was unaltered, production of superoxide radicals and hydrogen peroxide was markedly deficient in macrophages from GM-/- mice. Lipid peroxidation, assessed by measuring the isoprostane 8-iso-PGF2alpha, was decreased in the lungs of GM-/- mice. GM-CSF plays an important role in GBS clearance in vivo, mediated in part by its role in enhancing superoxide and hydrogen peroxide production and bacterial killing by alveolar macrophages.
Federated Learning in Mobile Edge Networks: A Comprehensive Survey (2020)

In recent years, mobile devices are equipped with increasingly advanced sensing and computing capabilities. Coupled with advancements in Deep Learning (DL), this opens up countless possibilities for meaningful applications, e.g., for medical purposes and in vehicular networks. Traditional cloud-based Machine Learning (ML) approaches require the data to be centralized in a cloud server or data center. However, this results in critical issues related to unacceptable latency and communication inefficiency. To this end, Mobile Edge Computing (MEC) has been proposed to bring intelligence closer to the edge, where data is produced. However, conventional enabling technologies for ML at mobile edge networks still require personal data to be shared with external parties, e.g., edge servers. Recently, in light of increasingly stringent data privacy legislations and growing privacy concerns, the concept of Federated Learning (FL) has been introduced. In FL, end devices use their local data to train an ML model required by the server. The end devices then send the model updates rather than raw data to the server for aggregation. FL can serve as an enabling technology in mobile edge networks since it enables the collaborative training of an ML model and also enables DL for mobile edge network optimization. However, in a large-scale and complex mobile edge network, heterogeneous devices with varying constraints are involved. This raises challenges of communication costs, resource allocation, and privacy and security in the implementation of FL at scale. In this survey, we begin with an introduction to the background and fundamentals of FL. Then, we highlight the aforementioned challenges of FL implementation and review existing solutions. Furthermore, we present the applications of FL for mobile edge network optimization. Finally, we discuss the important challenges and future research directions in FL.
Six-month evaluation of Carbatrol (extended-release carbamazepine) in complex partial seizures (1998)

We evaluated the use of a new, controlled-release capsule form of carbamazepine, Carbatrol capsules, in an open-label, multicenter study of 124 patients with complex partial seizures. Ninety-one percent of the patients successfully completed the 6-month trial with good seizure control, with a significant improvement in quality of life. We conclude that switching patients with complex partial seizures from multiple daily-dose carbamazepine to twice-daily Carbatrol on a milligram-to-milligram basis is relatively safe.
Previously unrecognised division within Moritella viscosa isolated from fish farmed in the North Atlantic (2010)

Previously undocumented phenotypical and genetic variation was identified amongst isolates of Moritella viscosa collected from various geographical locations and from different fish species. The studied isolates could be split into 2 major phenotypically and genetically different clusters, one of which was consistent with the species type strain (NCIMB 13548). Isolates consistent with the type strain originated exclusively from Atlantic salmon farmed in Norway, Scotland and the Faroe Isles, although a single isolate from farmed Norwegian cod clustered closely with this group. The 'variant' cluster comprised isolates originating from Norwegian farmed rainbow trout, Icelandic farmed rainbow trout and salmon, Canadian farmed (Atlantic) salmon, Icelandic lumpsucker and only exceptionally from Norwegian salmon. With the exception of the single aforementioned cod isolate, all isolates from Norwegian farmed cod belonged to the variant cluster. Phenotypically, the clusters could be absolutely separated only by elevated haemolytic activity in the variant strain, although approximately half of these isolates also produced acid from mannose, in contrast to the typical (type) strain. While 16S rRNA gene sequencing was unable to separate the 2 clusters, Western blot analyses, plasmid profile analysis, pulsed field gel electrophoresis and gyrB gene sequence analysis produced clusters consistent with the phenotypic data. Macroscopically and histologically the disease in rainbow trout caused by the variant strain was consistent with that previously described in Atlantic salmon. The results of the present study may indicate a degree of host specificity of the typical strain for Atlantic salmon.