gebhart/patrepeval huggingface dataset:
A Study on Strategy for Improving Health Care Service through Quality Function Deployment (1999)

【It is truism to say that today's customers demand high quality products and services; nevertheless, nowhere is this more prevalent than in the medical industry. Korea's globalization has increased it's citizen's awareness of greater life expectancies and medical improvements in other regions of the globe. Therefore, it is universally essential that in order to be successful in the medical industry, vendors must meet the ever increasing demands of better educated customers. The purpose of this study was twofold: 1) The first objective was discover what health care services are in demand and the quality factors related to these services. 2) The second objective was to determine a strategy for improving health care service through quality function deployment(QFD). One hundred and ninety-five respondents were randomly selected and asked to fill out a questionnaire after having undergone treatment at a medical clinic, located in Daejon, South Korea. The questionnaire was designed to obtain information about both he clients' satisfaction with, and their sense of the value of the medical treatment they received. Penalty-reward analysis and QFD were used to interpret the survey results and to deploy the collective voices of the customers. The results of the penalty-reward analysis illustrated that the 'communication' service quality factor was classified into an excitement factor that incurs no penalty if not achieved but adds value if the requirement is exceeded. As a result of the QFD analysis on the 'communication' service quality factor, eleven strategic alternatives were prioritized, and isolated a vital service quality characteristic. This characteristic can be implemented to bring value-added changes for the improvement of health care services.】
Pavement pothole detection and severity measurement using laser imaging (2011)

Over the years, Automated Image Analysis Systems (AIAS) have been developed for pavement surface analysis and management. The cameras used by most of the AIAS are based on Charge-Coupled Device (CCD) image sensors where a visible ray is projected. However, the quality of the images captured by the CCD cameras was limited by the inconsistent illumination and shadows caused by sunlight. To enhance the CCD image quality, a high-power artificial lighting system has been used, which requires a complicated lighting system and a significant power source. In this paper, we will introduce an efficient and more economical approach for pavement distress inspection by using laser imaging. After the pavement images are captured, regions corresponding to potholes are represented by a matrix of square tiles and the estimated shape of the pothole is determined. The vertical, horizontal distress measures, the total number of distress tiles and the depth index information are calculated providing input to a three-layer feed-forward neural network for pothole severity and crack type classification. The proposed analysis algorithm is capable of enhancing the pavement image, extracting the pothole from background and analyzing its severity. To validate the system, actual pavement pictures were taken from pavements both in highway and local roads. The experimental results demonstrated that the proposed model works well for pothole and crack detection.
Chemokines and atherosclerosis (2004)

Atherosclerosis is an inflammatory disease of the vessel wall, characterized by the accumulation of leukocytes, especially macrophages and T-cells. Chemokines are small heparin-binding polypeptides, whose main function is to attract cells to the areas of developing inflammation. They function by ligating G-protein coupled chemokine receptors initiating different signaling cascades. In vivo and in vitro investigations showed that chemokines are produced by a variety of cells and play important roles in the development and progression of many physiological and pathological conditions including atherosclerosis. Chemokines such as MCP-1, MCP-4, MIP-1 and RANTES may mediate leukocyte trafficking to, and their retention in, the plaque while CXCL16 seems to fulfill the dual function of a chemokine and a scavenger receptor. Chemokine and chemokine receptor homologues are secreted by several viruses, which may also play a role in the pathogenesis of atherosclerosis. Expression levels and gene polymorphisms of some chemokines may become useful clinical markers of atherosclerosis and other cardiovascular diseases. Modulation of chemokines and chemokine receptors' expression as well as their signaling pathways may provide important anti-atherogenic strategies.
Disialoganglioside GD2 as a therapeutic target for human diseases (2015)

Bridging the knowledge gaps in understanding the interactions of GD2 with signaling molecules within the glycosynapses, and the regulation of its cellular expression should improve therapeutic strategies targeting this ganglioside. In addition to anti-GD2 IgG mAbs, their drug conjugates, radiolabeled forms especially when genetically engineered to improve therapeutic index and novel bispecific forms or CARs to retarget T-cells are promising candidates for treating metastatic cancers.
Group 13 azatranes: synthetic, conformational, and configurational features (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGroup 13 azatranes: synthetic, conformational, and configurational featuresJiri Pinkas, Beverly Gaul, and John G. VerkadeCite this: J. Am. Chem. Soc. 1993, 115, 10, 3925–3931Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ja00063a011https://doi.org/10.1021/ja00063a011research-articleACS PublicationsRequest reuse permissionsArticle Views346Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of Atmospheric CO<sub>2</sub> Enrichment on the Growth and Mineral Nutrition of <i>Quercus alba</i> Seedlings in Nutrient-Poor Soil (1986)

One-year-old dormant white oak (Quercus alba L.) seedlings were planted in a nutrient-deficient forest soil and grown for 40 weeks in growth chambers at ambient (362 microliters per liter) or elevated (690 microliters per liter) levels of CO(2). Although all of the seedlings became severely N deficient, CO(2) enrichment enhanced growth by 85%, with the greatest enhancement in root systems. The growth enhancement did not increase the total water use per plant, so water-use efficiency was significantly greater in elevated CO(2). Total uptake of N, S, and B was not affected by CO(2), therefore, tissue concentrations of these nutrients were significantly lower in elevated CO(2). An increase in nutrient-use efficiency with respect to N was apparent in that a greater proportion of the limited N pool in the CO(2)-enriched plants was in fine roots and leaves. The uptake of other nutrients increased with CO(2) concentration, and P and K uptake increased in proportion to growth. Increased uptake of P by plants in elevated CO(2) may have been a result of greater proliferation of fine roots and associated mycorrhizae and rhizosphere bacteria stimulating P mineralization. The results demonstrate that a growth response to CO(2) enrichment is possible in nutrient-limited systems, and that the mechanisms of response may include either increased nutrient supply or decreased physiological demand.
USE OF p53 TRANSGENIC MICE IN THE DEVELOPMENT OF CANCER MODELS FOR MULTIPLE PURPOSES (2000)

The tumor suppressor gene p53 is perhaps the most commonly mutated gene in human cancer, being mutated in a high percentage of colon, breast, skin, bladder, and many cancers of the aerodigestive tract. Individuals with Li-Fraumeni syndrome, who routinely have a germline mutation in the p53 tumor suppressor gene, are at high risk for lung cancer, confirming its intimate role in lung tumorigenesis in humans. In contrast, the majority of chemically induced or spontaneous cancers in rodents do not contain mutations in p53. Therefore, we examined a transgenic mouse that contains a dominant negative mutation (Arg135Val) in the p53 gene placed under the control of its own endogenous promoter. The resulting mice have 3 copies of the mutated transgene as well as 2 normal p53 alleles. In the chemical carcinogenesis studies, we employed mice containing the mutated p53 gene to examine for carcinogen susceptibility. We found that mice with the p53 mutation, on an A/J F1 background, were more susceptible to a number of potential lung carcinogens, including N-methyl-N-nitrosourea (MNU) and the known tobacco carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo(a)pyrene (BP). Mice with a mutant p53 developed larger tumors and roughly 3 times as many tumors, emphasizing the potential effects of a p53 mutation both on tumor initiation and progression. In addition, we examined 2 nonlung carcinogens, 1,2-dimethylhydrazine (DMH), a colon carcinogen, and N-butyl-N-(4-hydroxybutyl)-nitrosamine (OHBBN), a bladder carcinogen. Interestingly a germline p53 mutation increased the incidence of DMH-induced colon, lung, hepatic, and uterine tumors, while having limited effects on OHBBN-induced bladder tumors. Because of its heightened susceptibility we are examining the use of this model in smoke-induced tumorigenesis in A/J mice as well. Employing the lung adenomas induced by NNK, we found that mice with or without a p53 mutation were equally susceptible to the chemopreventive effects of dexamethasone plus myo-inisitol and green tea. These tumors, which arise in a highly reproducible manner in p53 transgenic mice following carcinogen treatment, have mutations in both p53 and the K-ras oncogene. Thus, this model appears useful for examining for potential chemotherapeutic agents. p53-mutated or wild-type mice were equally susceptible to the therapeutic effects of Taxol or Adriamycin. Interestingly, piroxicam was similarly effective in inhibiting colon tumor formation by DMH in mice with or without a mutation in the p53 tumor suppressor gene. In contrast, lung and uterine tumors developing in these mice were not susceptible to the chemopreventive effects of piroxicam. In summary, mice with mutations in the p53 tumor suppressor gene appear to be particularly applicable for basic mechanistic studies, for screening for potential carcinogens, and for screening for chemopreventive or chemotherapeutic agents.
When What's Happening is Important (1996)

(1996). When What's Happening is Important. Kappa Delta Pi Record: Vol. 33, No. 1, pp. 8-14.
Thymocyte selection: not by TCR alone (1998)

During development of T cells in the thymus, T-cell receptor (TCR)-mediated recognition of self-MHC/self-peptide complexes on thymic stroma dictates the developmental fate of immature CD4+CD8+ (double positive) thymocytes. Intriguingly, TCR-generated intracellular signals can elicit two entirely different cellular responses in such thymocytes: apoptosis or further differentiation. The critical issue in understanding end-stage T-cell development is how TCR occupancy can be perceived in such markedly different ways by the TCR. Here, we review the cytoplasmic and nuclear events that result from TCR signaling during thymocyte selection. Studies aimed at distinguishing molecular components involved in positive selection (resulting in signals for further differentiation) and negative selection (resulting in apoptosis) will help solve this fascinating feature of T-lymphocyte biology. We also discuss how non-TCR-derived signaling might serve to fine tune the TCR-driven selection events in thymocytes. Central to this aspect of the conceptual framework needed to explain thymocyte selection is the observation that thymic antigen-presenting cells appear to be specialized in the induction of either positive or negative selection. Finally, we suggest a hypothesis that integrates the facts currently available on developing thymocytes, and which may serve to refine our exploration of unresolved issues in thymocyte selection. This hypothesis expands our focus to include signals from receptors other than TCRs as modulating and amplifying factors in thymocyte signaling.
Influence of impingement edge geometry on cavity flow oscillations (1994)

and back portion of the airfoil is shown in Figs. 2b and 2c, respectively. The smooth transition of the grid from one type to another and the decency of the grid at sharp corners and between close surfaces are clearly shown, which indicate excellent compatibility and communication between the two grid strategies as controlled by a common background grid. The grid was generated using a Silicon Graphics IRIS 4D/210 VOX workstation. The code's performance is about 360 triangles/s on that workstation and 2350 triangles/s on a Cray Y-MP. The total turnaround time required for generating a grid around a complex geometry, including the setup time, is about 1 h. To examine the fidelity of the grids generated with the present method, a turbulent viscous-flow computation was performed on the grid shown in Fig. 2. The flow solution was obtained with an available node-based, upwind flow solver8 using the BaldwinEarth turbulence model at a Mach number of 0.2, an angle of attack of 16.2 deg, and a Reynolds number of 9 X 106. Comparisons for surface pressure distributions and velocity profiles are shown in Figs. 3a and 3b, respectively. Excellent agreement with experimental data confirms the viability of the generated grid. Concluding Remarks A new method of unstructured viscous grid generation has been introduced. The approach is conceptually simple but powerful, and capable of producing high-quality viscous unstructured grids for complex configurations with ease. Being based on a totally unstructured grid strategy, the method is fully automatic and flexible and, thus, alleviates the difficulties stemming from the structural limitations of the existing structured or semi-unstruct ured techniques. Because of an efficient grid-marching strategy and a simple front-detection algorithm, the method is highly efficient and operational on small workstations. The method is also self-sufficient for insertion of grid points in the boundary layer and beyond. The method has been applied to two-dimensional problems with satisfactory results. The basic elements of the technique, however, have been primarily designed for its subsequent extension for generating three-dimensional highly stretched tetrahedral grids which is currently in progress. The full benefit of the method will be realized for generation of three-dimensi onal viscous grids where the complexity of the problem becomes excessive.
Surface water as source in the spread of cucumber green mottle mosaic virus. (1988)

CGMMV was first detected in surface water used for sprinkling irrigation of cucumbers in greenhouses in the spring and contamination reached a max. in Jun.-Jul. Virus concn were low in Aug. at the end of the cropping season when little irrigation is required, but levels rose in Sep. when the soil was leached. CGMMV was also found in seepage from dumping sites of cucumber fruits and crop debris, in packing containers and in manure from cows fed with virus-infected fruits. The virus was not found in tap or well water. (Abstract retrieved from CAB Abstracts by CABI’s permission)
A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester. (1989)

We constructed mutant protein kinase C (PKC) cDNAs which expressed PKC activity in vivo in the absence of phorbol ester activation. A hybrid PKC gene, PKAC, was constructed by substituting the coding region for the N-terminal 253 amino acids of PKC alpha with the N-terminal 17 amino acids of the cyclic AMP-dependent protein kinase catalytic subunit (PKA). A truncated PKC gene, delta PKC beta, lacking the coding region for amino acid positions 6 to 159 of PKC beta was also constructed. These mutant kinase genes expressed under the control of the SR alpha promoter activated the c-fos gene enhancer in Jurkat cells and initiated maturation of Xenopus laevis oocytes. Phorbol ester binding activity was absent in both constructs but was preserved in another hybrid gene, PKCA, which was composed of the coding region for 1 to 253 amino acids of PKC alpha at the N-terminal side and the coding region for 18 to 350 amino acids of PKA at the C-terminal side. These results indicate that elimination of the regulatory domain of PKC produces constitutively active PKC that can bypass activation by the phorbol ester. delta PKC beta, in synergy with a calcium ionophore, was capable of activating the interleukin 2 promoter, indicating that cooperation of PKC-dependent and calcium-dependent pathways is necessary for activation of the interleukin 2 gene.
Photoinduced Electron-Transfer-Promoted Redox Fragmentation of <i>N</i>-Alkoxyphthalimides (2011)

A new photoinduced electron-transfer-promoted redox fragmentation of N-alkoxyphthalimides has been developed. Mechanistic experiments have established that this reaction proceeds through a unique concerted intramolecular fragmentation process. This distinctive mechanism imparts many synthetic advantages, which are highlighted in the redox fragmentation of various heterocyclic substrates.
Cobalt complexes of BODIPY as precatalyst for the photooxidation of water and DHN (2014)

A cobalt complexes with intramolecular d–π interactions can be a light driven precatalysts to the oxidation of water.
C<i>1s</i>excitation studies of diamond (111). II. Unoccupied surface states (1986)

Unoccupied electronic states at the diamond (111) surface are studied by measuring both bulk- and surface-sensitive C 1s partial-yield soft-x-ray absorption spectra. Several absorption features are observed in the bulk band gap below the 289.19-eV bulk-C 1s absorption edge. They are associated with transitions from the C 1s surface core level to unoccupied surface states by their sensitivity to chemisorbed species and changes in their intensity as the electron escape depth is varied. These states have been detected previously with electron-energy-loss spectroscopy but no structure was resolved. The close proximity of the observed surface absorption (onset at h\ensuremath{\nu}=284 eV) with the h\ensuremath{\nu}=285.35 eV, C 1s\ensuremath{\rightarrow}${\ensuremath{\pi}}^{\mathrm{*}}$ transition in graphite indicates the existence of unoccupied ${\ensuremath{\pi}}^{\mathrm{*}}$ bands at the diamond (111) surface. An interpretation of these results in terms of the \ensuremath{\pi}-bonded chain model for the diamond (111) 2\ifmmode\times\else\texttimes\fi{}1 reconstructed surface is given.
Use of segmentation and labeling in analysis-synthesis of speech (2005)

We have been attempting to produce further bandwidth reduction in LPC based analysts-synthesis techniques by used the segmentation and labeling algorithms used in the Harpy and Hearsay-II systems. Preliminary results indicate that a factor of 3 to 5 further reduction in bandwidth might be possible using segmentation and labeling in conjunction with LPC vocoders.
The Effect of Parental Education on Emotions and Behaviors (2007)

Current literature suggests that emotions are learned through socialization. The following study was completed using results compiled by a survey done for the South Dakota State University (SDSU) Sociology of Rural America course (Soc 240). The authors wished to ask the question "Do the education levels of parents affect the emotions and behaviors of their children?" There were approximately 540 respondents to this survey, all college students at SDSU. Questions dealing with students' emotions were analyzed with respect to each respective student's parents' education level. The findings suggested that there is a connection between the parents' education levels and the emotions and behaviors of children.
Optimal Calibration of Map-Based Energy Management for Plug-In Parallel Hybrid Configurations: A Hybrid Optimal Control Approach (2014)

In this paper, an optimization framework for the calibration of energy management in plug-in hybrid electric vehicles (PHEVs) is proposed. The framework is based on the modeling of hybrid vehicles as hybrid systems in the mathematical sense, i.e., as a system, whose input is composed of continuous and discrete variables. This allows for the flexible integration of discrete decisions, such as drive modes and gear selection. Hybrid optimal control problems are then formulated, which seek optimal continuous and discrete system inputs, and methods for the efficient solution are described. The framework also allows for the incorporation of losses that occur due to a change in a discrete variable. The results can then be used to automatically calculate lookup tables for optimal gear shifts, optimal torque split between the motor/generator and the internal combustion engine, and the determination of the drive mode (electric or hybrid mode). It is demonstrated that when switching cost is disregarded, the main challenge is still finding the initial costate value. Practical strategies for determining the costate value online are described, containing a rule-based method, a CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> optimal method, and predictive energy management. The most important implementation issues are discussed, and the results of real-world experiments of predictive energy management are shown.
A discussion of <i>On the Purpose of Object-Oriented Analysis</i> (1993)

Article Free Access Share on A discussion of On the Purpose of Object-Oriented Analysis Authors: Dave Thomas Object Technology International Object Technology InternationalView Profile , Adele Goldberg ParcPlace Systems ParcPlace SystemsView Profile , James Coplien Bell Labs Bell LabsView Profile , Peter Coad Apple, Inc. Apple, Inc.View Profile , Geir Magne Høydalsvik Univ. of Trondheim, Trondheim, Norway Univ. of Trondheim, Trondheim, NorwayView Profile Authors Info & Claims OOPSLA '93: Proceedings of the eighth annual conference on Object-oriented programming systems, languages, and applicationsOctober 1993Pages 256–258https://doi.org/10.1145/165854.165899Published:01 October 1993Publication History 1citation664DownloadsMetricsTotal Citations1Total Downloads664Last 12 Months15Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF