gebhart/patrepeval huggingface dataset:
TMA: beware of complements (2013)

In this issue of Blood, Jodele and colleagues report that defective complement regulation contributes to the development of thrombotic microangiopathy (TMA) after hematopoietic stem cell transplantation (HSCT) with important implications for diagnosis and management of this severe clinical complication.
A single-blind, placebo-controlled trial of a simple acupuncture treatment in the cessation of smoking. (1998)

This simple ear electroacupuncture treatment was significantly more effective in helping volunteers to quit smoking than placebo treatment.
Critical current and linewidth reduction in spin-torque nano-oscillators by delayed self-injection (2015)

Based on theoretical models, the dynamics of spin-torque nano-oscillators can be substantially modified by re-injecting the emitted signal to the input of the oscillator after some delay. Numerical simulations for vortex magnetic tunnel junctions show that with reasonable parameters this approach can decrease critical currents as much as 25% and linewidths by a factor of 4. Analytical calculations, which agree well with simulations, demonstrate that these results can be generalized to any kind of spin-torque oscillator.
Chronobiological approach to etiology of urinary stone disease (1999)

To study circadian rhythm pattern of biochemical parameters important in etiology of urolithiasis viz. serum calcium, urinary calcium and urinary oxalate in healthy controls in order to set time-quantified norms of their levels in tropical conditions; and to compare with them the rhythm patterns of these parameters in patients of urolithiasis. North and northwestern India being in the stone belt, urolithiasis is a very common problem on our OPD rolls, its etiology being more confusing than conclusive, exploration of an alterative etiological approach to urolithiasis and its recurrence is being sought keeping in mind the time structure of human being.
Adjunctive dental therapy via tooth plaque reduction and gingivitis treatment by blue light-emitting diodes tooth brushing (2015)

The efficacy of blue light-emitting toothbrushes (B-LETBs) (405 to 420 nm, power density 2 mW/cm(2)) for reduction of dental plaques and gingival inflammation has been evaluated. Microbiological study has shown the multifactor therapeutic action of the B-LETBs on oral pathological microflora: in addition to partial mechanical removal of bacteria, photodynamic action suppresses them up to 97.5%. In the pilot clinical studies, subjects with mild to moderate gingivitis have been randomly divided into two groups: a treatment group that used the B-LETBs and a control group that used standard toothbrushes. Indices of plaque, gingival bleeding, and inflammation have been evaluated. A significant improvement of all dental indices in comparison with the baseline (by 59%, 66%, and 82% for plaque, gingival bleeding, and inflammation, respectively) has been found. The treatment group has demonstrated up to 50% improvement relative to the control group. We have proposed the B-LETBs to serve for prevention of gingivitis or as an alternative to conventional antibiotic treatment of this disease due to their effectiveness and the absence of drug side effects and bacterial resistance.
<title>Design, simulation model, and measurements for high-density interconnections</title> (1991)

High density interconnections are essential for high performance systems. For excellent signal fidelity it is essential to design interconnects as controlled impedance transmission lines in these systems. Results from design studies are summarized in this paper. Effects of substrate and conductor properties on the interconnect parameters are emphasized. Crosstalk noise is proportional to interconnection density. Crosstalk can be analyzed in SPICE using a set of isolated transmission line and congruence transformers synthesized with dependent sources A SPICE subcircuit for a pair of coupled interconnections is presented. Using this subcircuit crosstalk calculations are illustrated for systems based ECL and CMOS technologies. High density interconnects have considerable resistance. Results of a theoretical analysis of the time domain reflectometer (TDR) responses of a lossy interconnect are presented. These results can be used to determine the impedance and the effective resistance of the interconnections using a TDR. This technique is especially useful for digital systems using lossy transmission line approach.
A Role for Rev-erbα Ligands in the Regulation of Adipogenesis (2011)

Rev-erbs are members of the nuclear receptor (NR) transcription factor superfamily and are widely expressed, but are most prevalent in liver, adipose tissue, skeletal muscle and brain. Rev-erbs are key regulators of the circadian rhythm and are expressed in a circadian manner. The discovery that Rev-erbs are ligand-regulated receptors, whose repressive activity is regulated by the endogenous porphyrin ligand, heme, as well as the recent report of the first synthetic Rev-erb ligand, GSK4112/SR6452, suggests that pharmacological modulation through Rev-erb may provide new routes to treat metabolic diseases. Here, we review the work leading to the discovery that Rev-erbs are indeed ligand-regulated and the role that both natural and synthetic Rev-erb ligands have on adipogenesis.
DETERMINING CORRECTIVE ACTION FOR HIGHWAY LANDSLIDE PROBLEMS (1952)

A STUDY WAS CONDUCTED IN WEST VIRGINIA TO PREPARE AN APPROACH TO THE ANALYSIS AND CORRECTION OF HIGHWAY PROBLEMS DEALING WITH LANDSLIDES IN UNCONSOLIDATED MATERIALS. IT WAS DETERMINED THAT THE BASIS FOR THE CLASSIFICATION OF LANDSLIDES SHOULD BE ON THE MECHANICS OF THE MOVEMENT RATHER THAN ON CAUSE AND EFFECT. SINCE FOR A GIVEN HIGHWAY- LANDSLIDE PROBLEM THERE ARE NUMEROUS SOLUTIONS THE PROBLEM CAN BE REDUCED TO A PROBLEM IN ECONOMICS. THE DETRIMENTAL EFFECT OF WATER HAS BEEN REPEATEDLY EMPHASIZED, BUT THERE HAS NOT BEEN SUFFICIENT EMPHASIS ON THE FACT THAT THE FORCE OF GRAVITY IS ALWAYS PRESENT AS A CONTRIBUTING FACTOR. ANALYSES OF A LANDSLIDE SHOULD BE GOVERNED BY A BASIC PRINCIPLE OF OBTAINING A MORE STABLE SLOPE THAN EXISTED PRIOR TO FAILURE. STABILITY ANALYSIS METHODS ARE DISCUSSED.
Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers. (1992)

Expression of the Drosophila melanogaster Adh gene in adults requires a fat body-specific enhancer called the Adh adult enhancer (AAE). We have identified a protein in Drosophila nuclear extracts that binds specifically to a site within the AAE (adult enhancer factor 1 [AEF-1]). In addition, we have shown that AEF-1 binds specifically to two other Drosophila fat body enhancers. Base substitutions in the AEF-1 binding site that disrupt AEF-1 binding in vitro result in a significant increase in the level of Adh expression in vivo. Thus, the AEF-1 binding site is a negative regulatory element within the AAE. A cDNA encoding the AEF-1 protein was isolated and shown to act as a repressor of the AAE in cotransfection studies. The AEF-1 protein contains four zinc fingers and an alanine-rich sequence. The latter motif is found in other eukaryotic proteins known to be transcriptional repressors.
Electrochemical Characteristics of Six Aluminum Galvanic-Anode Alloys in the Sea (1970)

Previous studies1 of aluminum galvanic anodes in seawater have shown marked variations in electrochemical characteristics. Other authors have indicated satisfactory performance from aluminum anodes that contain mercury-zinc2,3 or indium-zinc.4 The present authors, in limited studies,1 also found that mercury-zinc aluminum anodes have desirable electrochemical characteristics in seawater. Because previous data showed variable performance of tin-zinc aluminum anodes from one production lot to another and from one manufacturer to another, a study of the consistency of performance of the mercury-zinc anode was included in the present experiment. Several anodes from two lots manufactured at each of two plants (widely separated geographically) were studied to investigate any variability in performance.
Capillary electrophoresis of cardiolipin with on‐line dye interaction and spectrophotometric detection (2003)

Cardiolipin is an important phospholipid present in the mitochondrial inner membrane. It plays a key function in mitochondrial respiration by interacting with many enzymes or cofactors related to oxidative phosphorylation complexes. We have determined the concentration of cardiolipin using on-line 10-N-nonyl acridine orange (NAO) dye interaction capillary electrophoresis (CE) and spectrophotometric detection with a sample throughput of 3 min. In addition to the presence of 0.1 mM NAO, the background electrolyte (BGE) composition has been set at 80% methanol-10% acetonitrile-10% H(2)O (all v/v) to provide both good solubility and the maximum absorbance enhancement at 497 nm for the NAO-cardiolipin complex as compared to NAO alone. Sample consumption for each injection is about 57 nL. A calibration curve is established from 0.5 microM to 0.1 mM with R (2) = 0.9912 with a detection limit of 0.05 microM for cardiolipin. In a blind study, actual mitochondrial cell membrane samples in the microL range before or after UV light exposure were analyzed using the CE method. Cardiolipin concentration decreased in the different parts of the membrane sample upon UV photolysis of the cells. Support for the theory that UV light can induce cardiolipin translocation from the inner membrane (IM) to the outer membrane (OM) was indicated by a significant percentage increase of cardiolipin (as measured by the cardiolipin in the OM as compared to the sum total in the OM and IM) from 30.7 +/- 2.4% before UV light photolysis to 38.3 +/- 2.2% after UV irradiation.
Screening Technologies for Ion Channel Drug Discovery (2010)

For every movement, heartbeat and thought, ion channels need to open and close. It is therefore not surprising that their malfunctioning leads to serious diseases. Currently, only approximately 10% of drugs, with a market value in excess of US$10 billion, act on ion channels. The systematic exploitation of this target class has started, enabled by novel assay technologies and fundamental advances of the structural and mechanistic understanding of channel function. The latter, which was rewarded with the Nobel Prize in 2003, has opened up an avenue for rational drug design. In this review we provide an overview of the current repertoire of screening technologies that has evolved to drive ion channel-targeted drug discovery towards new medicines of the future.
Eye Shape in Emmetropia and Myopia (2004)

Although there are considerable individual variations, in general myopic eyes are elongated relative to emmetropic eyes, more in length than in height and even less in width. Approximately a quarter of the myopic participants fitted each of the global expansion or axial elongation model exclusively. The small proportions are due primarily to the large variability in the dimensions of emmetropic eyes.
Tying Down the Elderly (1989)

The apparently widespread practice of physical restraint of the elderly has received little systematic research, despite reported clinical awareness of its iatrogenic effects on frail elders. Prevalence rates in various settings range between 6% and 86%, with cognitive impairment an important risk factor for restraint. Despite strongly held beliefs, efficacy of restraints for safeguarding patients from injury has not been demonstrated clinically. This paper reviews the current status of knowledge regarding physical restraint use with the elderly and suggests a research agenda and implications for ethical practice.
Reservations for aggregate traffic: experiences from an RSVP tunnels implementation (2002)

Among its various uses, IP-in-IP (Internet Protocol) tunneling is a simple way to aggregate the data flows from multiple sources to multiple destinations into one flow, to cross part of the Internet. In this paper, we report our design and implementation of RSVP (Resource ReSerVation Protocol) support for resource reservations over IP-in-IP tunnels, and our experience from this effort that revealed a number of issues related to making resource reservations for aggregate data flows. First, aggregation and de-aggregation go in pairs; thus, the exit point of the tunnel must have adequate information to be able to de-multiplex the aggregate tunnel reservation back to reservations for individual flows. Second, if multiple reserved sessions exist over one tunnel, the two tunnel end-points need mechanisms to synchronize on which end-to-end reservation is bound to which tunnel reservation. On the other hand, mapping all reservations of the same traffic class into one tunnel session can substantially simplify the protocol. Furthermore, one must also properly map error reports from the aggregate reservation back to the ends of individual flows.
Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13 (2011)

In genome-wide association studies (GWASs) of colorectal cancer, we have identified two genomic regions in which pairs of tagging-single nucleotide polymorphisms (tagSNPs) are associated with disease; these comprise chromosomes 1q41 (rs6691170, rs6687758) and 12q13.13 (rs7163702, rs11169552). We investigated these regions further, aiming to determine whether they contain more than one independent association signal and/or to identify the SNPs most strongly associated with disease. Genotyping of additional sample sets at the original tagSNPs showed that, for both regions, the two tagSNPs were unlikely to identify a single haplotype on which the functional variation lay. Conversely, one of the pair of SNPs did not fully capture the association signal in each region. We therefore undertook more detailed analyses, using imputation, logistic regression, genealogical analysis using the GENECLUSTER program and haplotype analysis. In the 1q41 region, the SNP rs11118883 emerged as a strong candidate based on all these analyses, sufficient to account for the signals at both rs6691170 and rs6687758. rs11118883 lies within a region with strong evidence of transcriptional regulatory activity and has been associated with expression of PDGFRB mRNA. For 12q13.13, a complex situation was found: SNP rs7972465 showed stronger association than either rs11169552 or rs7136702, and GENECLUSTER found no good evidence for a two-SNP model. However, logistic regression and haplotype analyses supported a two-SNP model, in which a signal at the SNP rs706793 was added to that at rs11169552. Post-GWAS fine-mapping studies are challenging, but the use of multiple tools can assist in identifying candidate functional variants in at least some cases.
Mutational analysis of the domain structure of mouse protein phosphatase 2Cβ (1998)

The structures of five distinct isoforms of mammalian protein phosphatase 2Cbeta (PP2Cbeta-1, -2, -3, -4 and -5) have previously been found to differ only at their C-terminal regions. In the present study, we performed mutational analysis of recombinant mouse PP2Cbeta-1 to determine the functional domains of the molecule and elucidate the biochemical significance of the structural differences in the isoforms. Differences in affinity for [32P]phosphohistone but not for [32P]phosphocasein were observed among the five PP2Cbeta isoforms. Deletion of 12 amino acids from the C-terminal end, which form a unique sequence for PP2Cbeta-1, caused a 35% loss of activity against [32P]phosphohistone but no loss of activity against [32P]phosphocasein. Deletion of up to 78 amino acids from this end did not cause any further alteration in activity, whereas deletion of 100 amino acids totally eliminated the activity against both [32P]phosphohistone and [32P]phosphocasein. On the other hand, deletion of 11 amino acids from the N-terminal end caused a 97% loss of enzyme activity, and further deletions caused a total loss of activity. Substitution of any of the six specific amino acids among 16 tested in this study, which were located among the 250 N-terminal residues, caused 98-100% loss of enzyme activity. Among these amino acids, three (Glu-38, -60 and -243) have recently been reported to be essential for the binding of metal ions in the catalytic site of the PP2C molecule [Das, Helps, Cohen and Barford (1996) EMBO J. 15, 6798-6809]. These observations indicate that PP2Cbeta is composed of at least two distinct functional domains, an N-terminal catalytic domain of about 310 amino acids and the remaining C-terminal domain, which is involved in determination of substrate specificity.
Colorimetric Determination of Tetrachlorohydroquinone (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTColorimetric Determination of TetrachlorohydroquinoneSverre DahlCite this: Anal. Chem. 1953, 25, 11, 1724–1727Publication Date (Print):November 17, 1953Publication History Published online1 May 2002Published inissue 17 November 1953https://pubs.acs.org/doi/10.1021/ac60083a035https://doi.org/10.1021/ac60083a035research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
HEART FAILURE IN PATIENTS WITH HIGH BLOOD PRESSURE (1959)

In the course of four years work in a clinic for the investigation and follow up of high blood pressure, the impression has been gained that although hypertension may increase greatly the work of the heart, the heart does not fail unless some additional embarrassment is imposed. Hypoten- sive drugs have, by reducing the work load of the heart, increased the relative importance of these additional factors.
An automated software verification tool for model-based development of embedded systems with simulink® (2009)

This paper describes the implementation of an automated test tool developed in Matlab <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reg</sup> /Simulink <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reg</sup> environment that supports model testing and software verification in model-based development of control applications. This tool based on `black box' testing strategy serves on the one hand to check the ldquosemanticrdquo or ldquofunctionalrdquo correctness (SiL: software-in-the-loop) of automatically with RTW (real time workshop <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reg</sup> ) generated C-code for algorithms designed and modelled in Simulink <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reg</sup> and on the other hand to compare the obtained results with the results of the simultaneously running model-in-the-loop test (MiL). The aim behind this tool is to develop reliable software that fulfils system requirements, assure quality and can perform satisfactorily in the intended deployment environment.
Pattern defect study using cover material film in immersion lithography (2006)

In immersion lithography, it is necessary that the surface of wafer has high hydrohybicity in order to prevent the residue of immersion fluid, i.e. pure water, that cause watermark defect. Usage of a cover material film over the resist film is effective to consistent with high hydrohybicity of the surface and high performance of resist film. But it was problem that much pattern deformation defects was observed with the use of an alkali-soluble type cover material film and an immersion exposure tool. As a result of the examination, it was identified that the fraction of film which caused the pattern deformation in the area of several micrometers were the fraction of the cover material. And the fractions of cover coat material were oriented in the coating defects of the cover material film and in the film peeling after scan of the immersion nozzle at the wafer bevel. The coating defects were improved with the chemical of the cover material. An adhesion process was effective to prevent the film peeling of cover material.
New developments expand Coilbox applications (1995)

The Coilbox solves a basic problem of hot strip rolling--loss of temperature of the transfer bar before rolling in the finishing stands. In new mills, the Coilbox allows a shorter mill with less horsepower. In retrofit mills, it allows a wider product range, and increased slab and coil size. The Coilbox helps the hot strip mill operator meet the market demand for wider, lighter gage strip, larger coils, tighter tolerance and improved metallurgical uniformity. In principle, the Coilbox is a coiling device, consisting of a three-roll bending arrangement for coiling the transverse bar. When coiling is complete, the rotation of the coil is reversed and the exposed tail is peeled off and threaded into the finishing train. Once threaded, the coil is moved to allow another transfer bar to be coiled. All operations are fully automated and process controlled by means of programmable computer. This allows the combining of crop shear and Coilbox operator functions into one operator station. Recent development will allow the Coilbox technology to be used in thin slab casting and continuous rolling concepts.
Differentiating Vector-Derived mRNA fromContaminating DNA Templates by Inverse RT-PCR (2001)

Inverse RT-PCR was used for detecting doxycycline-induced mRNA expression after viral transduction with a retroviral vector harboring human TDAG51. After the circularization of double-stranded cDNA, induced transcripts originating from integrated vector genomes were selectively amplified, even in the presence of DNA templates. Thus, DNase treatment before amplification was unnecessary.
Role of Notch signaling in regulating innate immunity and inflammation in health and disease (2016)

The Notch signaling pathway is conserved from Drosophila to mammals and is critically involved in developmental processes. In the immune system, it has been established that Notch signaling regulates multiple steps of T and B cell development in both central and peripheral lymphoid organs. Relative to the well documented role of Notch signaling in lymphocyte development, less is known about its role in regulating myeloid lineage development and function, especially in the context of acute and chronic inflammation. In this review article, we will describe the evidence accumulated during the recent years to support a key regulatory role of the Notch pathway in innate immune and inflammatory responses and discuss the potential implications of such regulation for pathogenesis and therapy of inflammatory disorders.