gebhart/patrepeval huggingface dataset:
<scp>d</scp> -Arabitol Catabolic Pathway in <i>Klebsiella aerogenes</i> (1974)

Klebsiella aerogenes strain W70 has an inducible pathway for the degradation of d-arabitol which is comparable to the one found in Aerobacter aerogenes strain PRL-R3. The pathway is also similar to the pathway of ribitol catabolism in that it is composed of a pentitol dehydrogenase, d-arabitol dehydrogenase (ADH), and a pentulokinase, d-xylulokinase (DXK). These two enzymes are coordinately controlled and induced in response to d-arabitol, the apparent inducer of synthesis of these enzymes. We obtained mutants which lacked a functional d-xylose pathway and were constitutive for the ribitol catabolic pathway. These mutants were able to grow on the unusual pentitol, xylitol, only if they contained the functional DXK of the d-arabitol pathway. This provided us with a specific selection technique for DXK(+) transductants. As in A. aerogenes, mutants constitutive for ADH were able to use this enzyme to convert the hexitol d-mannitol to d-fructose. With mutants blocked in the normal d-mannitol catabolic pathway, growth on d-mannitol became a test for ADH constitutivity. Growth of such mutants on xylitol, d-arabitol, and d-mannitol was utilized to classify transductants in mapping, by transductional analysis, the loci involved in d-arabitol utilization. Three-point crosses gave the order dalK-dalD-dalC, where dalK is the DXK structural gene, dalD is the ADH structural gene, and dalC is a regulatory site controlling synthesis of both enzymes.
Inosine Monophosphate Dehydrogenase as a Target for Antiviral, Anticancer, Antimicrobial and Immunosuppressive Therapeutics (2009)

Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step in the de novo biosynthesis of guanine nucleotides. In recent years it has become the target of multiple drugs in an attempt to cure a variety of diseases. Possible therapeutic drugs range from antiviral and anticancer to immunosuppressive targets. Research has shown that if IMPDH is effectively inhibited, cancerous growth can be slowed and virus replication can be stopped. Microbial and parasitic IMPDH differ significantly from the human isoforms and targeting those isoforms could lead to effective treatments for many diseases. Inhibiting IMPDH is an extremely promising therapy for a variety of disease states. Isoform- and species-selective inhibition is desirable and scientists are making significant progress in these areas.
Efficient Imaging and Real-Time Display of Scanning Ion Conductance Microscopy Based on Block Compressive Sensing (2014)

Scanning Ion Conductance Microscopy (SICM) is one kind of Scanning Probe Microscopies (SPMs), and it is widely used in imaging soft samples for many distinctive advantages. However, the scanning speed of SICM is much slower than other SPMs. Compressive sensing (CS) could improve scanning speed tremendously by breaking through the Shannon sampling theorem, but it still requires too much time in image reconstruction. Block compressive sensing can be applied to SICM imaging to further reduce the reconstruction time of sparse signals, and it has another unique application that it can achieve the function of image real-time display in SICM imaging. In this article, a new method of dividing blocks and a new matrix arithmetic operation were proposed to build the block compressive sensing model, and several experiments were carried out to verify the superiority of block compressive sensing in reducing imaging time and real-time display in SICM imaging.
The acoustics of Japanese wooden drums called “mokugyo” (2005)

A drumlike traditional Japanese instrument, the mokugyo, is experimentally discussed. First, the acoustic characteristics of 176 mokugyos with diameters ranging from 7.5 to 120 cm and three drumsticks were measured. Results show that (a) the sound spectra consist of two common peaks [F1 (Hz): first peak frequency, F2 (Hz): second peak frequency] close together, with an average ratio (F2/F1) of 1.15, and (b) a drumstick beating the mokugyo is translated into an impact force applied over a period of time from 1 to 6 ms related to the mass and stiffness of the material wrapped around the tip of the drumstick. Second, to evaluate the acoustic response of a mokugyo in the final tuning process, the mechanical and acoustical analogy between the mokugyo and a bass reflex loudspeaker is theoretically and experimentally discussed. Results show that the model can be estimated within a relative error of 0.52% from the mass of wood chips. Finally, from a psychological experiment, the timbre of the mokugyo shows higher scores on psychological scales' when the ratio (F2/F1) becomes 1.15.
Fludarabine and cyclophosphamide using an attenuated dose schedule is a highly effective regimen for patients with indolent lymphoid malignancies (2004)

The FC schedule used in the current study was found to be highly effective in patients with indolent lymphoid malignancies. Toxicity was lower compared with higher dose schedules, whereas efficacy appeared to be equivalent.
KRAS Codon 12 and 13 Mutations in Gastric Cancer in the Northeast Iran (2018)

In conclusion, the overall frequency of <i>KRAS</i> codon 12 and 13 mutations in GC was 30% in the current study population.Frequency of <i>KRAS</i> codon 12 and 13 mutations hadsignificant correlation with tumors location. Different pathogenic mechanismsare suggested for GC according to tumor location. The current study resultsmay be an important diagnostic tool for physicians managing atrophic gastritis.
A prospective, cytogenetic study of recurrent abortion. (1969)

Many workers have now recorded a high inci- dence of chromosomal abnormalities in sponta- neously aborted foetuses, particularly in those aborted in the first trimester of pregnancy and in those which are macroscopically abnormal. Kerr and Rashad (1966) found an incidence of 21% of chromosomal abnormalities in 400 specimens re- corded in the world literature. A higher incidence of abnormalities may be found in series confined to first trimester abortions, ranging from 33% (Kerr and Rashad, 1966) to over 60% The common abnormali- ties of karyotype are 45,X, various trisomies, and triploidy or tetraploidy. Occasional autosomal monosomies have been reported in early specimens (Inhorn, Therman, and Patau, 1964; Kelly et al., 1965; Jacobson and Barter, 1967; Waxman, Arakaki, and Smith, 1967).
The Reliability of Bleaching Techniques for the Determination of Latent Image Distribution in Silver Bromide and Iodobromide Emulsions<sup>*</sup> (1961)

The reliability of various bleaching Techniques was studied on the basis that a bleach should destroy surface latent image compleldy and that the internal speed should be independent of the precise bleaching conditions ond be as high as possible. Only two treatments satisfied these conditions. These were a potassium-ferricyanide-phenosafranine bleach and a silver-dichramale bleach ofter a washing treatment.
Physics and environment (1970)

In this issue our feature articles focus on the subject of environmental problems. On page 26 Marvin Goldberger explains generally how physicists can contribute in this area. Following him on page 32 Hans Panofsky points out how heavily modern meteorology draws on various branches of physics. On page 38 Ali Cambel reviews the projected increases in demand for energy and the ways that these increases might be achieved with minimum threat to the environment. The three authors originally presented their papers at the recent Annual Meeting of Society Officers and Corporate Associates of the American Institute of Physics. Besides "Physics and Environment," speakers at the meeting also presented papers concerned with "Physics and Life Sciences" and "Physics and Energy Sources." The prize winners of the photographic competition held by PHYSICS TODAY for each of these three subject areas were first announced at this meeting. Each winner received an award of $200. Following are reproductions of the prize-winning photographs.
The spacer domain of ADAMTS13 contains a major binding site for antibodies in patients with thrombotic thrombocytopenic purpura (2005)

Thrombotic thrombocytopenic purpura (TTP) is a microangiopathy often associated with a severely decreased activity of ADAMTS13. In plasma of the majority of patients with TTP, antibodies are present that inhibit the von Willebrand factor (VWF) processing activity of ADAMTS13. We describe a sensitive assay that monitors binding of recombinant ADAMTS13 to immobilized IgG derived from patient plasma. Analysis of fifteen patients with TTP and severely reduced ADAMTS13 activity revealed that in all patients antibodies directed to ADAMTS13 were present. Levels of anti-ADAMTS13 antibodies varied considerably among patients, specific antibody levels in plasma range from less than 100 ng/ml to over 1 microg/ml. Longitudinal analysis in three patients revealed that anti-ADAMTS13 antibody levels declined with different kinetics. For further characterization of anti-ADAMTS13 antibodies, we prepared a series of recombinant fragments corresponding to the various ADAMTS13 domains. All seven TTP plasma samples tested, showed reactivity of antibodies towards a fragment consisting of the disintegrin/TSR1/cysteine-rich/spacer domains. In one patient, we also observed reactivity towards the TSR2-8 repeats. No binding of antibodies to propeptide, metalloprotease and CUB domains was detected. To further delineate the binding site in the disintegrin/TSR1/cysteine-rich/spacer region, we prepared additional ADAMTS13 fragments. Antibodies directed towards the cysteine-rich/spacer fragment were found in all plasma samples analyzed. No antibodies reacting with the disintegrin/TSR1 domains were detected. A recombinant fragment comprising the spacer domain was recognized by all patients samples analyzed, suggesting that the 130-amino-acid spacer domain harbors a major binding site for anti-ADAMTS-13 antibodies.
MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia (2002)

MDM2 protein is thought to exhibit tumorigenic activity by binding to the p53 tumor-suppressor protein and inhibiting its function. Alternatively, MDM2 may have oncogenic roles other than those resulting from p53 interactions. Here we report that MDM2 can induce expression of the p65 subunit of NF-kappaB, which is an anti-apoptotic factor expressed in certain neoplastic cells in response to chemotherapy. Initially, we noted that the overexpression of MDM2 protein in leukemic bone marrow cells of patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and an ALL cell line (EU-4) transfected with the MDM2 gene was associated with elevated expression of p65 and in vitro resistance to doxorubicin (Adriamycin). By cotransfection of the MDM2 gene and p65-promoter-reporter constructs into EU-4 cells, we found that transient and high-level MDM2 expression induced p65 promoter activity. In the presence of wild-type (wt) p53, MDM2 increased p65 promoter activity by reversing p53-mediated suppression of p65. In the absence of p53, MDM2 directly increased p65 promoter activity. Deletion and mutation analysis of the p65 promoter indicated that the region between nt -575 and -178, which contains the first and second Sp1-binding sites, was required for activation by MDM2. Further studies using chromatin immunoprecipitation (CHIP) and electrophoretic mobility shift assay (EMSA) showed that MDM2 was able to directly bind to the Sp1 site of the p65 promoter. Our findings suggest that by inducing p65 expression, MDM2 has a p53-independent role in tumorigenesis, which may further elucidate the association between MDM2 overexpression and resistant disease in childhood ALL.
Políticas económicas y sociales y desarrollo humano local en América Latina: El caso de Venezuela (2008)

La publicacion responde al interes que ha despertado, especialmente en America Latina pero tambien en otras partes del mundo, la utilizacion por el gobierno encabezado por el Presidente Chavez de los ingresos derivados de la renta petrolera para la satisfaccion de las necesidades de la mayoria de la poblacion venezolana, sobre todo de sus sectores mas pobres, asi como de la extension de la democracia participativa en amplios campos de la vida social. Esta politica contrasta con la practicada en otras epocas, en las que de esa renta se beneficiaban exclusivamente las clases dominantes y las multinacionales petroleras. Las repetidas y amplias victorias electorales de Chavez solo pueden explicarse por una politica que ha contribuido a una mejora importante del bienestar de la mayoria. Los trabajos que publicamos permiten comprender la envergadura interna e internacional que permite la utilizacion solidaria e internacionalista de los recursos petroleros (Busqueta Franco), un balance de las politicas economicas desarrolladas por los sucesivos gobiernos de Hugo Chavez desde 1998 (Montero Soler) y una detallada apreciacion del impacto de las politicas sociales en la reduccion de la desigualdad social (Magallanes). El analisis (de Viciano Pastor y Dalmau) sobre la propuesta de la reforma constitucional apunta criticas politicas y tecnicas sobre el texto. La derrota de esta propuesta en el referendum de 2 de diciembre de 2007 de alguna manera atestigua las debilidades de la propuesta y, sobre todo, de algunas inconsistencias de la politica gubernamental y de la limitada eficacia de la administracion publica. La inversion de este reves requiere que la democracia participativa se extienda a todos los aspectos de la vida social, se coordine de forma que consiga que la satisfaccion de las necesidades populares defina las prioridades presupuestarias en todos los niveles (comunales, regionales y a escala nacional) y que se profundicen los derechos democraticos, principalmente los que afectan a los trabajadores y trabajadoras en las empresas.
Addressing the challenges of mission-critical information management in next-generation net-centric pub/sub systems with OpenSplice DDS (2008)

An important class of new and existing applications requires cooperating entities to share and exchange information seamlessly in real-time, while meeting stringent requirements for quality of service (QoS) and heterogeneity. This paper describes how the recently adopted OMG DDS standard, and the OpenSplice DDS implementation of this standard, support the data distribution and management challenges posed by next-generation distributed systems, and systems of systems.
Overview of Eukaryotic In Vitro Translation and Expression Systems (1998)

The ability to investigate cellular processes in vitro permits detailed analysis of the process and its molecular components. Eukaryotic translation and expression is one system that has been well studied. This overview describes the development of in vitro systems, including such approaches as continuous-flow systems, coupled transcription/translation, and the incorporation of non-natural amino acids. It also discusses molecular and genetic studies to probe translation, including post-translational fate of the synthesized proteins.
Pathological and genetic analysis of the degenerating muscle (dmu) mouse: a new allele of Scn8a (2001)

Here, we describe a novel spontaneous autosomal recessive mutation in the mouse that is characterized by skeletal and cardiac muscle degeneration. We have named this mutant degenerating muscle (dmu). At birth, mutant mice are indistinguishable from their normal littermates. Thereafter, the disease progresses rapidly and a phenotype is first observed at approximately 11 days after birth; the dmu mice are weak and have great difficulty in moving. The principal cause of the lack of mobility is muscle atrophy and wasting in the hindquarters. Affected mice die at or around the time of weaning of unknown causes. Histopathological observations and ultrastructural analysis revealed muscle degeneration in both skeletal and cardiac muscle, but no abnormalities in sciatic nerves. Using linkage analysis, we have mapped the dmu locus to the distal portion of mouse chromosome 15 in a region syntenic to human chromosome 12q13. Interestingly, scapuloperoneal muscular dystrophy (SPMD) in humans has been linked to this region. SPMD patients with associated cardiomyopathy have also been described in the past. Initial analysis of candidate genes on mouse chromosome 15 reveal that although intact transcripts for Scn8a, the gene encoding the sodium channel 8a subunit, are present in dmu mice, their levels are dramatically reduced. Furthermore, genetic complementation crosses between dmu and med (mutation in Scn8a) mice revealed that they are allelic. Our results suggest that at least a portion of the dmu phenotype is caused by a down-regulation of Scn8a, making dmu a new allele of Scn8a.
A real-time rate control scheme and hardware implementation for H.264/AVC encoders (2012)

Rate control plays an important role in video encoders with the complex application environment and limited network bandwidth to obtain a better performance. According to the features of the encoded bit stream, rate control algorithm can dynamically adjust the quantization parameter in different levels of the encoding procedure. In this paper, a real-time rate control scheme for hardware implementation in H.264/AVC encoders is proposed. Different from other rate control algorithms focusing on the performance without considering the cost of hardware realization, the proposed scheme is applicable for hardware implementation with low hardware complexity. The simulation results show that the proposed scheme has lower fluctuation in video quality, and owns almost the same visual quality as that of X.264. The proposed scheme is implemented using SIMC 65nm CMOS technology with a clock frequency of 240MHz, which can be easily integrated into our low cost, real-time video encoder.
Rapid Method to Account for Process Variation in Full-Chip Capacitance Extraction (2004)

Full-chip capacitance extraction programs based on lookup techniques, such as HILEX/CUP , can be enhanced to rigorously account for process variations in the dimensions of very large scale integration interconnect wires with only modest additional computational effort. HILEX/CUP extracts interconnect capacitance from layout using analytical models with reasonable accuracy. These extracted capacitances are strictly valid only for the nominal interconnect dimensions; the networked nature of capacitive relationships in dense, complex interconnect structures precludes simple extrapolations of capacitance with dimensional changes. However, the derivatives, with respect to linewidth variation of the analytical models, can be accumulated along with the capacitance itself for each interacting pair of nodes. A numerically computed derivative with respect to metal and dielectric layer thickness variation can also be accumulated. Each node pair's extracted capacitance and its gradient with respect to linewidth and thickness variation on each metal and dielectric layer can be stored in a file. Thus, instead of storing a scalar value for each extracted capacitance, a vector of 3I+1 values will be stored for capacitance and its gradient, where I is the number of metal layers. Subsequently, this gradient information can be used during circuit simulation in conjunction with any arbitrary vector of interconnect process variations to perform sensitivity analysis of circuit performance.
Low-power CMOS at Vdd=4kT/q (2002)

Summary form only given. This paper reports a CMOS inverter active power-delay product of less than 0.1 fJ/stage at 25/spl deg/C and at Vdd=0.1 V. We believe this is the lowest reported. This is accomplished by using a novel technique to match NFET and PFET subthreshold currents and, thus, enable operation of a standard 1.5 V 180 nm CMOS technology in subthreshold at very low Vdd. This technique uses voltage feedback to the MOSFET wells to match the NFET off current (Ioffn) and PFET off current (Ioffp), significantly enhancing the manufacturability of CMOS subthreshold logic.
Synthesis and evaluation of peptidyl vicinal tricarbonyl monohydrates as inhibitors of hydrolytic enzymes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and evaluation of peptidyl vicinal tricarbonyl monohydrates as inhibitors of hydrolytic enzymesHarry H. Wasserman, David S. Ennis, Patricia L. Power, Mitchell J. Ross, and Bruce GomesCite this: J. Org. Chem. 1993, 58, 18, 4785–4787Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/jo00070a005https://doi.org/10.1021/jo00070a005research-articleACS PublicationsRequest reuse permissionsArticle Views393Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A uniplanar 90-GHz Schottky-diode millimeter-wave receiver (1995)

A 90 GHz Schottky-diode receiver based on a double slot antenna fed by a coplanar-waveguide (CPW) transmission line is presented. The double slot antenna is placed on an extended hemispherical high-resistivity silicon substrate lens. The uniplanar receiver results in a 9.3/spl plusmn/0.3 dB measured SSB conversion loss at 88-90 GHz including antenna and IF circuit losses and a 1-dB loss due to the use of a nonoptimal matching cap layer at the silicon lens-air interface. The calculated conversion loss agrees very well with the RF measurements. The uniplanar double-slot antenna receiver is very small, less than 1.1/spl times/4 mm including the RF/IF filter, and is compatible with monolithic two- and three-terminal devices on GaAs substrates. The application areas are in millimeter-wave receivers for automotive systems, communication systems, and radiometric linear imaging arrays.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>