gebhart/patrepeval huggingface dataset:
The effect of nanodiamonds on candida albicans adhesion and surface characteristics of PMMA denture base material - an in vitro study (2019)

PMMA/NDs composites could be valuable in the prevention of denture stomatitis, which is considered one of the most common clinical problems among removable denture wearers.
A Distributed File System with Variable Sized Objects for Enhanced Random Writes (2016)

Cloud-based file systems are widely accepted and adopted for personal and business purposes in recent years. Statistics shows that ∼25% of file operations from a typical user are random writes. Inherited from traditional disk-based file systems, most distributed file systems are also based on objects or chunks of fixed sizes, which work well for sequential writes but poorly for random writes. This paper investigates the design paradigm of variable-sized objects for a distributed file system, where a new file write interface is proposed to provide rich write semantics. A novel distributed file system named VarFS, is presented to incorporate variable object indexing, support the random write interface and remain POSIX compatible. VarFS reduces the amount of unnecessary data being read and the number of objects modified in face of updates and consequently alleviates the total amount of data transferred. VarFS is implemented based on Ceph and the performance measurements show that it can achieve 1–2 orders of magnitude less latency than Ceph on random writes. At the same time, the overhead for initial writes and re-writes is acceptable.
Heart Failure – Pathophysiology and Current Therapeutic Implications (2020)

The concept of translational medicine involves promoting the rapid transfer of observations made in the areas of research and pathophysiological understanding to the medical practice. This approach is a reality in major Brazilian research centers which link academia and clinical practice. Heart failure (HF) is a complex syndrome that can manifest itself as heart failure with preserved ejection fraction (HFpEF), acute heart failure, or chronic heart failure with reduced ejection fraction (HFrEF). Here, we will cover the type of HF [...]
stg fimbrial operon from S. Typhi STH2370 contributes to association and cell disruption of epithelial and macrophage-like cells (2015)

S. Typhi stg operon encodes a functional adhesin that participates in the interaction bacteria-eukaryotic cells, including epithelial cells and macrophages-like cells. The phenotypes associated to stg operon include increased association and consequent invasion in bacteria-eukaryotic cells, and cell disruption.
Mechanism of action of mRNA-based vaccines (2017)

The present review summarizes the growing body of work defining the mechanisms of action of this exciting new vaccine technology that should allow rational approaches in the design of next generation mRNA vaccines. Areas covered: Bio-distribution of mRNA, localization of antigen production, role of the innate immunity, priming of the adaptive immune response, route of administration and effects of mRNA delivery systems. Expert commentary: In the last few years, the development of RNA vaccines had a fast growth, the rising number of proof will enable rational approaches to improving the effectiveness and safety of this modern class of medicine.
Verification and Validation of Modern Software Systems (2000)

From the Publisher:
Verification & Validation of Modern Software-Intensive Systems brings the classic approaches up to date to apply them to contemporary computing methods. Based on the latest standards and research, the authors cover VV object orientation, knowledge-based systems, and rapid application development; data warehousing; and Graphical User Interface (GUI) development and usability.
Using Yeast RNA as a Probe for Generation of Hydroxyl Radicals by Earth Materials (2006)

Inhalation of certain types of particulate matter can lead to lung disease. The reactivity of these particles and, in part, the pathologic responses that result are dictated by their physicochemical properties. The ability of particles to induce the generation of reactive oxygen species (ROS), especially hydroxyl radicals in vivo, is one property that has been correlated to the development of lung disease. Several minerals, such as quartz and asbestos, are known to generate hydroxyl radicals and cause lung disease, but many other minerals have never been tested. Here, we describe a technique employing yeast RNA as a probe to screen for mineral-generated hydroxyl radicals. The stability of RNA in the presence of hydrogen peroxide, ferrous iron, hydroxyl radicals, and several common minerals (quartz, albite, forsterite, fayalite, hematite, magnetite, coal, and pyrite) was examined. 3'-(p-Aminophenyl) fluorescein (APF) was used to verify mineral generation of ROS. RNA is stable in the presence of hydrogen peroxide, quartz, and albite; while it degrades in the presence of ferrous iron, hydroxyl radicals, and the other minerals. Coal and pyrite are the most reactive both in RNA degradation and hydroxyl radical generation. This noncellular technique provides a straightforward way to compare many different particles simultaneously. Those particles showing reactivity toward RNA using this method are high-priority candidates for further in vitro and possibly in vivo tests.
Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis (2011)

Chronic inflammation plays important roles at different stages of cancer development, including carcinogenesis, tumor invasion, and metastasis, but molecular mechanisms linking inflammation to cancer development have not been fully clarified. Here, we report that expression of angiopoietin-like protein 2 (Angptl2), recently identified as a chronic inflammation mediator, is highly correlated with the frequency of carcinogenesis in a chemically induced skin squamous cell carcinoma (SCC) mouse model. Furthermore, Angptl2 expression in SCC is highly correlated with the frequency of tumor cell metastasis to distant secondary organs and lymph nodes. When SCC was induced in transgenic mice expressing Angptl2 in skin epithelial cells, epithelial-to-mesenchymal transitions in SCC as well as tumor angiogenesis and lymphangiogenesis were significantly increased, resulting in increased tumor cell metastasis and shortened survival compared with wild-type mice. Conversely, in a chemically induced SCC mouse model, carcinogenesis and metastasis were markedly attenuated in Angptl2 knockout mice, resulting in extended survival compared with wild-type mice. Overall, we propose that Angptl2 contributes to increased carcinogenesis and metastasis and represents a novel target to antagonize these pathologies.
[Joint action of protein-chondroitin-4-keratan-sulfate and hyaluronic acid on erythrocyte aggregation and adhesion]. (1977)

It was shown that the rate and the degree of erythrocytes aggregation brought about by a mixture of protein-chondroitin-4-keratan sulfate (PCKS) and hyaluronic acid (HA) was greater than the sum of the values of the corresponding indices observed during separate independent action of these proteoglycans on the aggregation of the mentioned cells concentrations as in the mixtures. It may be supposed that such phenomenon is connected with formation in the mixture of a hybrid PCKS-HA complex which is more active in respect to the erythrocyte aggregation than its components separately.
Dimerization of Granulocyte-Colony Stimulating Factor Receptor: The Ig Plus CRH Construct of Granulocyte-Colony Stimulating Factor Receptor Forms a 2:2 Complex with a Ligand (1997)

We have previously shown that the extracellular domain of granulocyte-colony stimulating factor receptor (soluble G-CSFR), prepared from CHO cell conditioned media, dimerizes upon binding its ligand, G-CSF. The most stable ligand-receptor complex occurs at a 2:2 stoichiometry, unlike the growth hormone and erythropoietin systems. In the latter cases, each ligand uses two sites to bring two receptors together. In this study, we have generated a truncated G-CSF receptor, known to be sufficient for high affinity ligand binding, which consists of an Ig-like domain and a cytokine receptor homology module. With an affinity purified receptor, sedimentation equilibrium experiments clearly demonstrated that this truncated form of the receptor behaves very similarly to the entire extracellular domain. The sedimentation equilibrium data are consistent with the model that the truncated receptor has a weak tendency to self-associate into a dimer in the absence of a ligand, this receptor-receptor interaction is enhanced by ligand binding, and the most stable complex occurs at a 2:2 stoichiometry. These results are very different from those described by others for various murine G-CSF receptor constructs from either Escherichia coli or insect expression systems.
[Intraocular pressure elevation after subtenon injection of triamcinolone acetonide during uveitis]. (2002)

and conclusions: Periocular subtenon injection of triamcinolone acetonide in posterior noninfectious uveitis is a safe procedure. Intraocular pressure elevation is not frequent and can be controlled through medical treatment or surgical excision of a residual deposit, in which pharmacologically active triamcinolone can be present several months after the injection.
A Fault Tolerant Integrated Electronics Module for Small Satellites (2025)

The Johns Hopkins University Applied Physics Laboratory (JHU/APL) Space Department has developed the JHU/APL Integrated Electronics Module (APL IEM) architecture for future satellites to minimize development costs while maximizing mission flexibility. The architecture supports both low earth orbit and deep space missions. Redundant and single string configurations are possible. Core spacecraft functions including communications, guidance, navigation, attitude, power control, health and safety, command, and data handling are implemented in the APL IEM. Extensive use is made of industry standards. Adhering to these standards at subsystem boundaries allows us to incrementally improve these designs without impacting the remainder of the system. Internal subsystems communicate over redundant, IEEE 1394, high speed, low power, serial buses. External interfaces include dedicated device specific links as well as those already in common satellite use. However, an unusual distributed approach to engineering housekeeping data acquisition based on the I2C industrial bus improves flexibility and increases design reusability.
Design and experimental studies of a generalized bilateral controller for a teleoperator system with a six DOF master and a seven DOF slave (2002)

Generalized bilateral control in teleoperation enables scaling, indexing, impedance control, shared control and the ability to use a non-replica master slave system. In this paper, control laws for both master and slave are derived for a desired impedance of the teleoperator system. A teleoperator system with six-degree-of-freedom Kraft hand controller (master) and a seven-degree-of-freedom Robotics Research Corporation manipulator (slave), is used as a testbed for generalized bilateral control. Parameter selection guidelines for the controller design are developed based on experimental studies of the teleoperator system. An assembly task is performed to test the effectiveness of the controller design.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
σ receptors (1991)

The sigma receptor is a neuronal substrate that binds several psychoactive compounds. These include cocaine, some steroids, dextromethorphan, phencyclidine (PCP), and benzomorphans such as pentazocine and N-allyl-normatezocine (SKF-10047). Many newer atypical antipsychotic drugs also bind to the sigma receptor. The sigma receptor, however, is not the PCP receptor. The sigma receptor exists in the central nervous system, endocrine, immune and certain peripheral tissues. Progesterone and certain steroids have been shown to represent endogenous ligands for the sigma receptor. The sigma receptor resides likely in the nonsynaptic region of the plasma membrane. The sigma receptor exists in two forms: high-affinity and low-affinity. The solubilized sigma receptor retains all of the pharmacological characteristics of a membrane-bound receptor. A major physiological role of the sigma receptor may involve the modulation of a tonic potassium channel.
Pipelining and overlapping for mpi collective operations (2004)

Collective operations are an important aspect of the currently most important message-passing programming model MPI (message passing interface). Many MPI applications make heavy use of collective operations. Collective operations involve the active participation of a known group of processes and are usually implemented on top of MPI point-to-point message passing. Many optimizations of the used communication algorithms have been developed, but the vast majority of those optimizations is still based on plain MPI point-to-point message passing. While this has the advantage of portability, it often does not allow for full exploitation of the underlying interconnection network. In this paper, we present a low-level, pipeline-based optimization of one-to-many and many-to-one collective operations for the SCI (scalable coherent interface) interconnection network. The optimizations increase the performance of some operations by a factor of four if compared with the generic, tree-based algorithms.
Acanthamoebae bind to rabbit corneal epithelium in vitro. (1997)

Rabbit animal model may prove useful for investigation of the molecular mechanisms that mediate adhesion of Acanthamoeba to corneal epithelium.
High-LET Radiation Carcinogenesis (1985)

The dose-response curves for the induction of tumors by high-LET radiation are complex and are insufficiently understood. There is no model or formulation to describe the dose-response relationship over a range 0-100 rad. Evidence suggests that at doses below 20 rad the response is linear, at least for life shortening and some tumor systems. Thus limiting values of RBEs for the induction of cancer in various tissues can be determined, but it will require sufficient data obtained at low single doses or with small fractions. The results obtained from experiments with heavy ions indicate an initial linear response with a plateauing of the curve at a tumor incidence level that is dependent on the type of tissue. The RBE values for the heavy ions using 60Co gamma rays as the reference radiation increase with the estimated LET from 4 or 4H to about 27 for 56Fe and 40Ar. The dose responses and RBEs for 56Fe and 40Ar are similar to those for fission neutrons. These findings suggest the possibility that the effectiveness for tumor induction reaches a maximum.
Efficacy and safety of olokizumab in Asian patients with moderate-to-severe rheumatoid arthritis, previously exposed to anti-TNF therapy: Results from a randomized phase II trial (2015)

OKZ demonstrated improvements in efficacy variables versus placebo in Asian patients with moderately-to-severely active RA who had previously failed anti-TNF therapy. The safety profile was as expected for this class of drug.
Mouse monoclonal antibody to a latent epitope of leucocyte receptors for leukotriene B4. (1992)

Human blood polymorphonuclear (PMN) leucocytes and human leucocytes of the HL-60 line, which were induced to differentiate by 1,25-dihydroxyvitamin D3, express stereospecific receptors for the potent chemotactic mediator, leukotriene B4 (LTB4), that is derived by 5-lipoxygenation from arachidonic acid. Monoclonal antibodies to LTB4 receptors (LTB4-R) were generated by immunizing BALB/c mice with partially purified PMN leucocyte membrane proteins, and fusing their splenocytes with P3X63Ag8 mouse myeloma cells. Hybridoma supernatants were screened initially by binding to PMN leucocyte LTB4-R protein, which had been affinity cross-linked with aminopropylamide (APA)-LTB4 and immobilized in plastic wells through attachment of the linked APA-LTB4 to adherent Fab of monoclonal anti-LTB4. Of the three clones producing antibodies which bound to LTB4-R, 0.5 mg/ml of one IgG3k antibody, termed E2, precipitated over 90% of the [3H]LTB4-binding activity of solubilized PMN leucocyte membrane proteins. E2 also bound to a radiolabelled protein of 70,000-80,000 MW from 125I-labelled PMN leucocyte membranes [35S]-labelled HL-60 cell membranes, and PMN leucocyte membranes affinity-labelled with [3H]APA-LTB4, that was identical in size to the LTB4-R precipitated by the rabbit IgG anti-idiotypic antibodies. E2 did not bind to intact PMN leucocytes or modify the binding of [3H]LTB4 by PMN leucocytes. The binding of E2 to LTB4-R in purified membranes of PMN leucocytes was less than one-fourth of that observed for the anti-idiotypic antibodies, but increased substantially after solubilization of the LTB4-R. The E2 monoclonal antibody thus recognizes a partially latent substituent of LTB4-R, which does not contribute to combining site function.
On Wave Field Synthesis and electro-acoustic music, with a particular focus on the reproduction of arbitrarily shaped sound sources (2008)

Seit Beginn der elektroakustischen Musik stößt das Thema des räumlichen Klanges unter Komponisten auf großes Interesse. Durch die kontinuierliche technische Entwicklung konnten und können diesbezüglich zunehmend Methoden zur Realisierung von Raumklang erreicht und neue Konzepte angeregt werden. Die Wellenfeldsynthese (WFS) zeichnet eine gewichtige Methode aus, die eine klare Lokalisation von virtuellen Klangquellen für einen großen Hörraum kreiert. Trotz des hierfür notwendigen hohen technischen und finanziellen Aufwands gewinnt die Wellenfeldsynthese international an vielen Instituten an Popularität, wodurch Komponisten und Klangkünstlern in zunehmendem Maße Zugang zu dieser Technologie ermöglicht wird. In dieser Beziehung zwischen Technologie und Künstlern bietet sich die Möglichkeit der Erforschung der Stärken und Schwächen, ebenso wie der Weiterentwicklung der Technologie bei gleichzeitigem Herstellen von Inhalten durch die Künstler. Dieses ist auch der Schlüssel des Erfolges, um die Nachfrage für die WFS anzuregen und ihr einen größeren Markt zu erschließen. Um eine größere und detailliertere Kontrolle über Klangquellen liefern zu können, wird in dieser Dissertation eine Methode vorgestellt für die Reproduktion (mittels WFS) von willkürlich geformten Klang-aussendenden Objekten. Diese Methode geht von einer bekannten, beziehungsweise einer definierten Geometrie der Oberfläche eines Objektes aus und nimmt eine bekannte oder definierte Schwingung dieser Oberfläche an. Mit diesen Parametern werden Signale für ein WFS-Lautsprecher-Array, durch die Anwendung eines angepassten WFS-Operator berechnet, welcher auf die Position über und unter der horizontalen Ebene sowie die Beugung des Klangs um das Objekt herum Bezug nimmt. Diese Methode wird durch die Kalkulation einiger Beispiele überprüft, wobei die Effekte von Größe-, Form-, Verfeinerungs-, Distanz- und Beugungsparametern auf das resultierende von den Lautsprechern wiedergegebene Wellenfeld ausgewertet werden. Das Beugungsmodell ergibt plausibele Resultate; es tritt aber ein zweite Stufe'' der Beugung auf, auf dem Lautsprecher-Array. Ein Hörtest hat deutlich gezeigt, das die Schallquellen, die auf diese Weise wiedergegeben wurden, deutlich wahrnehmbare Eigenschaften aufweisen. Als Erstes ist ein Effekt auf die Klangfarbe zu hören, aber des weiteren auch in verschiedenen räumlichen Parametern wie Quellenbreite, Lokalisation und Räumlichkeit.
The impact of search engines in the world today (2018)

Web search engines have major impact on people's everyday life. It is of great importance to test the retrieval effectiveness of search engines. Successful searching of information on the internet depends on techniques such as going straight to the information source, guess work and developing strategies for when to use subject directories and search engines. The utility of the web may match the skills of a professional reference librarian because it possesses an ever-changing and extremely heterogeneous document collection of immense proportions. Experiments on major search engines show that the approach to web research mines many high-confidence rules that help understand search engines and detect suspicious search results.
Human Values in Critical Care Medicine (1988)

Human values in critical care medicine , Human values in critical care medicine , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
Determinants Involved in the Affinity of α-Conotoxins GI and SI for the Muscle Subtype of Nicotinic Acetylcholine Receptors (1997)

Nicotinic acetylcholine receptors from muscle contain two functionally active and pharmacologically distinct acetylcholine-binding sites located at the alpha/gamma and alpha/delta subunit interfaces. The alpha-conotoxins are competitive antagonists of nicotinic receptors and can be highly site-selective, displaying greater than 10,000-fold differences in affinities for the two acetylcholine-binding sites on a single nicotinic receptor. The higher affinity site for alpha-conotoxins GI, MI, and SI is the alpha/delta site on mouse muscle-derived BC3H-1 receptors. However, alpha-conotoxins GI and MI exhibit higher affinity for the other site (alpha/gamma site) on nicotinic receptors from Torpedo californica electric organ. alpha-Conotoxin SI does not distinguish between the two acetylcholine-binding sites on Torpedo receptors. In this study, alpha-conotoxins [K10H]SI and [K10N]SI displayed wild-type affinity for the two acetylcholine-binding sites on BC3H-1 receptors but a 10-20-fold decrease in apparent affinity at one of the two acetylcholine-binding sites on Torpedo receptors. alpha-Conotoxin [P9K]SI displayed a selective and dramatic increase in the apparent affinity for the alpha/delta site of BC3H-1 receptors and for the alpha/gamma site of Torpedo receptors. alpha-Conotoxin [R9A]GI displayed a reduction in affinity for both acetylcholine-binding sites on BC3H-1 receptors, although the extent of its selectivity for the alpha/delta site was retained. alpha-Conotoxin [R9A]GI also displayed a loss of affinity for the two acetylcholine-binding sites on Torpedo receptors, but its site-selectivity was apparently abolished. These results indicate that positions 9 and 10 in alpha-conotoxins GI and SI are involved in complex species- and subunit-dependent interactions with nicotinic receptors.
Composite Films of Oxidized Multiwall Carbon Nanotube and Poly(3,4-ethylenedioxythiophene): Polystyrene Sulfonate (PEDOT:PSS) As a Contact Electrode for Transistor and Inverter Devices (2012)

Composite films of multiwall carbon nanotube (MWNT)/poly(3,4-ethylenedioxythiophene) polymerized with poly(4-styrenesulfonate) (PEDOT:PSS) were prepared by spin-coating a mixture solution. The effect of the MWNT loading and the MWNT oxidation, with acid solution or ultraviolet (UV)-ozone treatment, on the film properties such as surface roughness, work function, surface energy, optical transparency and conductivity were studied. Also pentacene thin film transistors and inverters were made with these composite films as a contact metal and the device characteristics were measured. The oxidation of MWNT reduced the conductivity of MWNT/PEDOT:PSS composite film but increased the work function and transparency. UV-ozone treated MWNT/PEDOT:PSS composite film showed higher conductivity (14000 Ω/□) and work function (4.9 eV) than acid-oxidized MWNT/PEDOT:PSS composite film and showed better performance as a source/drain electrode in organic thin film transistor (OTFT) than other types of MWNT/PEDOT:PSS composite films. Hole injection barrier of the UV-ozone treated MWNT/PEDOT:PSS composite film with pentacene was significantly lower than any other films because of the higher work function.