gebhart/patrepeval huggingface dataset:
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis (2010)

Mixed-lineage leukemia (MLL) is a proto-oncogene frequently involved in chromosomal translocations associated with acute leukemia. These chromosomal translocations commonly result in MLL fusion proteins that dysregulate transcription. Recent data suggest that the MYB proto-oncogene, which is an important regulator of hematopoietic cell development, has a role in leukemogenesis driven by the MLL-ENL fusion protein, but exactly how is unclear. Here we have demonstrated that c-Myb is recruited to the MLL histone methyl transferase complex by menin, a protein important for MLL-associated leukemic transformation, and that it contributes substantially to MLL-mediated methylation of histone H3 at lysine 4 (H3K4). Silencing MYB in human leukemic cell lines and primary patient material evoked a global decrease in H3K4 methylation, an unexpected decrease in HOXA9 and MEIS1 gene expression, and decreased MLL and menin occupancy in the HOXA9 gene locus. This decreased occupancy was associated with a diminished ability of an MLL-ENL fusion protein to transform normal mouse hematopoietic cells. Previous studies have shown that MYB expression is regulated by Hoxa9 and Meis1, indicating the existence of an autoregulatory feedback loop. The finding that c-Myb has the ability to direct epigenetic marks, along with its participation in an autoregulatory feedback loop with genes known to transform hematopoietic cells, lends mechanistic and translationally relevant insight into its role in MLL-associated leukemogenesis.
The pharmacology of No. 48-80, a long-acting vasodepressor drug. (1953)

1. Some pharmacological properties of No. 48-80, a highly potent depressor substance obtained by the condensation of N-methylhomoanisylamine with formaldehyde, have been described. 2. The effects of sub-lethal doses resemble those of histamine in many respects although the drug does not possess histamine-like properties itself. 3. No. 48-80 also exhibits certain properties not shown by injected histamine.
Extraction of hemicellulose from ryegrass straw for the production of glucose isomerase and use of the resulting straw residue for animal feed (1980)

Abstract The hemicellulose fraction of ryegrass straw was extracted with NaOH and used for the production of glucose isomerase by Streptomyces flavogriseus . The level of hemicellulose extracted increased proportionately with increasing NaOH concentration up to about 4%, then the rate of increase slowed down. Hemicellulose extraction was facilitated by the combined application of heat and NaOH. Approximately 15% hemicellulose (12% as pentosan) could be obtained by treating straw with 4% NaOH for either 3 hr at 90°C or 24 hr at room temperature. The highest level (3.04 units/ml culture) of intracellular glucose isomerase was obtained when the organism was grown at 30°C for two days on 2% straw hemicellulose. The organism also produced a high yield of glucose isomerase on xylose or xylan. The NaOH‐treated straw residue, after removal of hemicellulose, had approximately 75% higher digestibility and 20% higher feed efficiency for weanling meadow voles than untreated straw. Thus, the residue could be used as animal feed. A process for the production of glucose isomerase and animal feed from ryegrass straw was also proposed.
High Rank 7th Graders' Ideas on the Appropriate Inquiry Problems (2002)

To investigate the pupils' ideas about appropriate scientific inquiry problem, we have chosen the 105 boys and girls of 7th grade in a middle school in Seoul, Korea. Their marks in science are within the highest one-third of their classes. The pupils have made their own scientific inquiry questions, which is to be investigated by themselves in summer vacation. The 105 inquiry questions were gathered and evaluated by the pupils with 5-point Likert scale. From these, we have found that the questions inquiring novel phenomena, questioning causality, or containing scientific terms were evaluated as appropriate. Some questions were changed during performance. The pupils have changed their inquiry problems if they feel any difficulties in performing the inquiry.
PERBEDAAN TUMBUH KEMBANG ANAK PADA POSYANDU YANG TERINTEGRASI PAUD DENGAN POSYANDU TIDAK TERINTEGRASI PAUD (2011)

Data dari Organisasi Kesehatan Dunia (WYiO/World Health Organization) menunjukkan kesehatan masyarakat Indonesia terendah di ASEAN yaitu peringkat ke-142 dari 170 negara. Data hasil Riset Kesehatan Dasar (RISKESDAS) tahun 200, prevalensi gizi buruk di Indonesia adalah 5,4%, gizi kurang 13,0% dan masalah kependekan (stunting) 36,8%. Provinsi Sumatera Barat prevalensi gizi buruk balita sebesar 6,0%, gizi kurang sebesar 13,9% dan masalah kependekan 36,5%. Anak yang menderita KEP mengalami keterlambatan perkembangan dibandingkan dengan anak yang status gizinya normal. Pengoptimalan tumbuh kembang anak salah satunya dapat dikembangkan melalu posyandu yang terintegrasi PAUD. Tujuan penelitian untuk mengetahui perbedaan tumbuh kembang anak balita pada posyandu yang terintegrasi PAUD dan yang tidak terintegrasi PAUD. Penelitian data sekunder ini menggunakan disain crosssectional, bersumber dari penelitian "Model PengembanganAnak Usia Dini yang Holistik dan Terintegrasi pada Posyandu, Pos PAUD, Pos Integrasi dan Pos KB/TPA di KabupatenTanah Datar dan Kota Sawahlunto Propinsi Sumatera Barat Tahun 2009." Populasi adalah anak usia 2-5 tahun yang berjumlah 146 orang. Semua populasi dijadikan subjek penelitian. Data sekunder terdiri dari data perkembangan dan data Z Score BB/U, TB/U dan BB/TB anak usia 2-5 tahun, kemudian diolah dengan menggunakan program komputer. Analisis bivariat dengan uji Chisquare untuk mengetahui perbedaan proporsi status gizi dan perkembangan anak usia 2-5 tahun pada posyandu terintegrasi dengan tidak terintegrasi PAUD. Hasil penelitian ini menemukan proporsi anak usia 2-5 tahun mempunyai perkembangan tidak sesuai usianya lebih tinggi pada posyandu tidak terintegrasi PAUD sebesar 46,6%, dimana pada usia 2-3 tahun sebesar 70,6%, usia 3-4 tahun sebesar 62,5% dan usia 4-5 tahun sebesar 66,7%. Persentase anak dengan status gizi kurang dan kurus lebih tinggi pada posyandu tidak terintegrasi PAUD , sedangkan persentase anak pendek lebih tinggi pada posyandu terintegrasi PAUD. Disimpulkan ada perbedaan perkembangan dan status gizi anak usia 2-5 tahun berdasarkan indikator BB/TB pada posyandu terintegrasi dan tidak terintegrasi PAUD (p < 0,05). Disarankan kepada Dinas Kesehatan Kabupaten Tanah Datar dan Kota Sawahlunto bagian promosi kesehatan sebaiknya meningkatkan informasi dan promosi kesehatan tentang posyandu terintegrasi PAUD terutama untuk anak usia 2-5 tahun agar tumbuh kembang anak dapat dicapai dengan optimal.
Designing and Manufacturing of Automatic Robotic Lawn Mower (2021)

This study is about the manufacturing of a personified automatic robotic lawn mower with image recognition. The system structure is that the platform above the crawler tracks is combined with the lawn mower, steering motor, slide rail, and webcam to achieve the purpose of personification. Crawler tracks with a strong grip and good ability to adapt to terrain are selected as a moving vehicle to simulate human feet. In addition, a lawn mower mechanism is designed to simulate the left and right swing of human mowing to promote efficiency and innovation, and then human eyes are replaced by Webcam to identify obstacles. A human-machine interface is added so that through the mobile phone remote operation, users can choose a slow mode, inching mode, and obstacle avoidance mode on the human-machine interface. When the length of both sides of the rectangular area is input to the program, the automatic robotic lawn mower will complete the instruction according to the specified path. The chip of a Digital Signal Processor (DSP) TMS320F2808 is used as the core controller, and Raspberry Pi is used as image recognition and human-machine interface design. This robot can reduce labor costs and improve the efficiency of mowing by remote control. In addition to the use as an automatic mower on farms, this study concept can also be used in the lawn maintenance of golf courses and school playgrounds.
Effective and efficient user interaction for long queries (2008)

Handling long queries can involve either pruning the query to retain only the important terms (reduction), or expanding the query to include related concepts (expansion). While automatic techniques to do so exist, roughly 25% performance improvements in terms of MAP have been realized in past work through interactive variants. We show that selectively reducing or expanding a query leads to an average improvement of 51% in MAP over the baseline for standard TREC test collections. We demonstrate how user interaction can be used to achieve this improvement. Most interaction techniques present users with a fixed number of options for all queries. We achieve improvements by interacting less with the user, i.e., we present techniques to identify the optimal number of options to present to users, resulting in an interface with an average of 70% fewer options to consider. Previous algorithms supporting interactive reduction and expansion are exponential in nature. To extend their utility to operational environments, we present techniques to make the complexity of the algorithms polynomial. We finally present an analysis of long queries that continue to exhibit poor performance in spite of our new techniques.
THE CLINICAL AND CYTOLOGIC STUDIES ON UROTHELIAL TUMORS OF THE UPPER URINARY TRACT (1978)

The prognostic studies on 56 patients with primary urothelial tumors of the upper urinary tract treated surgically at the Keio Universty Hospital during a period from 1966 to 1977 were statistically reviewed.Overall actual survival rate in total 56 patients was 61%. Current beliefe indicates that prognosis of patients with urothelial tumor is determined by grade and stage of the tumor. In the present study, the following factors contributing to the prognosis of the patients with upper urothelial tumor were statistically analized.1) Grade and stage of malignancy.2) Operative procedure.3) Presence of multicentric tumor and/or subsequent urotehlial tumor.4) Interval from onset of symptoms to diagnosis.5) Age.There was a positive correlation between tumor invasion to muscle layer or renal parenchyma and prognosis.Total nephroureterectomy with excision of cuff of the bladder yielded the best result for patients with high grade and high stage of the tumor. But different operative procedures, irrespe-ctive of its kind, yielded similar good results for patients with low grade and low stage.Unique aspect of urothelial tumor, characterized by multicentricity contributing to the prognosis of the patients, was considered. Delay in detection of the upper urothelial tumor was found to result in poor prognosis, thereofre, the importance of accurate early diagnosis of upper urothelial tumor should be emphasized.
Saveme: client-side aggregation of cloud storage (2015)

Nowadays, there are many cloud storage service providers and many of them provide significant amounts of free storage. It is desirable for users to be able to manage the storage space available to them as a single unified space. Otherwise, user files will be scattered over many different providers, negating the advantage of using cloud storage. Another important concern of users is that their data is at the disposal of the service providers. Lastly, in contrast to the hype of extremely high availability, accidents tend to happen and even the most available cloud services are not accessible many times per year or even per month. SaveMe is designed to solve all of these issues, providing aggregation, security, and higher availability purely from the client side. It is the first approach to address all three issues without any additional server component. To achieve these goals, SaveMe is building a single virtual volume by combining public and private cloud storage. In SaveMe, every file is fully encrypted, erasure coded, and distributed. For better security and privacy, all data processes are performed on the client side, unlike the case of conventional cloud storage services. The logical volume of SaveMe is extensible due to a flexible data and volume model. The authors also tested the performance of SaveMe in comparison with those of existing services. SaveMe showed above average performance in terms of the speeds of uploading or downloading files. Furthermore, data availability evaluation clearly demonstrates that the availability of SaveMe is an order of magnitude higher than those of other commercial cloud storage services.
Use of a sperm analyzer for evaluating broiler breeder males. 1. Effects of altering sperm quality and quantity on the sperm motility index (1998)

A new instrument for assessing mammalian semen attributes, the Sperm Quality Analyzer, was evaluated as a potential tool for determining rooster sperm quality. The Sperm Quality Analyzer measures the "activity" of sperm in a semen sample as the sperm motility index (SMI). The SMI is defined as the number and amplitude of deflections in a light path per second as a result of sperm movement within a capillary tube. In the present study, effects of sperm concentration, viability, and motility on the SMI were evaluated. Peterson broiler breeder males (n = 40) were used as semen donors. In the initial experiment, semen was diluted from 2- to 25-fold and SMI readings were obtained. The SMI was very low in neat semen samples but increased when semen was diluted up to threefold. However, at dilutions greater than fivefold, the SMI decreased. Apparently, sperm concentration in undiluted semen is so great that sperm are unable to move freely within the capillary tube. Maximum SMI values were obtained at sperm concentrations of approximately 1 billion sperm per milliliter. When thawed, dead sperm were mixed with incubated, live sperm, the SMI decreased with decreasing sperm viability even though sperm concentration was constant. Obviously, fewer sperm move across the light beam as sperm mortality increases. When motile, aerobically incubated sperm were mixed at different rates with immotile, anaerobically incubated sperm samples, the SMI increased with increasing concentrations of motile sperm, whereas total sperm concentration was static. In addition, the SMI was strongly correlated with motility scores obtained by microscopic analysis. The Sperm Quality Analyzer provides an estimate of the overall quality of sperm from broiler breeder males by reflecting sperm concentration, viability, and motility in a single value, the SMI.
Silicones for Stretchable and Durable Soft Devices: Beyond Sylgard-184 (2018)

This paper identifies and characterizes silicone elastomers that are well-suited for fabricating highly stretchable and tear-resistant devices that require interfacial bonding by plasma or UV ozone treatment. The ability to bond two or more pieces of molded silicone is important for creating microfluidic channels, chambers for pneumatically driven soft robotics, and other soft and stretchable devices. Sylgard-184 is a popular silicone, particularly for microfluidic applications. However, its low elongation at break (∼100% strain) and moderate tear strength (∼3 N/mm) make it unsuitable for emerging, mechanically demanding applications of silicone. In contrast, commercial silicones, such as Dragon Skin, have excellent mechanical properties yet are difficult to plasma-bond, likely because of the presence of silicone oils that soften the network yet migrate to the surface and interfere with plasma bonding. We found that extracting silicone oligomers from these soft networks allows these materials to bond but only when the Shore hardness exceeds a value of 15 A. It is also possible to mix highly stretchable silicones (Dragon Skin and Ecoflex) with Sylgard-184 to create silicones with intermediate mechanical properties; interestingly, these blends also only bond when the hardness exceeds 15 A. Eight different Pt-cured silicones were also screened; again, only those with Shore hardness above 15 A plasma-bond. The most promising silicones from this study are Sylgard-186 and Elastosil-M4130 and M4630, which exhibit a large deformation (>200% elongation at break), high tear strength (>12 N/mm), and strong plasma bonding. To illustrate the utility of these silicones, we created stretchable electrodes by injecting a liquid metal into microchannels created using such silicones, which may find use in soft robotics, electronic skin, and stretchable energy storage devices.
Development of a Competitive Index Assay To Evaluate the Virulence of<i>Listeria monocytogenes actA</i>Mutants during Primary and Secondary Infection of Mice (2001)

We developed a competitive index assay for murine listeriosis that tests the virulence of Listeria monocytogenes strains in different organs and at various times postinoculation. Studies presented here demonstrate the reproducibility of this assay during primary and secondary infection of inbred and outbred mice. We verified the validity of this assay by performing competitive index analysis of a well-characterized strain of L. monocytogenes lacking the actA gene. In addition, we found that while L. monocytogenes strains unable to recruit vasodilator-stimulated phosphoprotein (VASP) to their surface exhibit a 10-fold virulence attenuation in the livers of naive animals, they display a 50-fold survival defect in the liver during secondary listeriosis.
Polyamides from tetrahydrofuran‐2,5‐dipropionic acid: The effects of the tetrahydrofuran ring inserted in the chain of polyamide molecule (1955)

Abstract A homologous series of polyamides from tetrahydrofuran‐2,5‐dipropionic acid and polymethylenediamine (nylon nT, n = 2, 4 ∼ 10) and two series of copolyamides (nylon 66/6T and 69/6T) have been prepared. Based on studies of the properties of these polymers the effects of tetrahydrofuran ring on polymer properties have been discussed. The introduction of tetrahydrofuran ring into polyamide chain has little influence on melting point and christallinity of the polymer, but fairly increases the solubility, moisture regain, and receptivity towards dyes. The copolyamide 66/6T (wt. ratio 4 : 1) gives a fibre having good mechanical properties and greatly improved dyeing properties.
Lattice Gas Models and Kinetic Monte Carlo Simulations of Epitaxial Growth (2005)

A brief introduction is given to Kinetic Monte Carlo (KMC) simulations of epitaxial crystal growth. Molecular Beam Epitaxy (MBE) serves as the prototype example for growth far from equilibrium. However, many of the aspects discussed here would carry over to other techniques as well. A variety of approaches to the modeling and simulation of epitaxial growth have been applied. They range from the detailed quantum mechanics treatment of microscopic processes to the coarse grained description in terms of stochastic differential equations or other continuum approaches. Here, the focus is on discrete representations such as lattice gas and Solid-On-Solid (SOS) models. The basic ideas of the corresponding Kinetic Monte Carlo methods are presented. Strengths and weaknesses become apparent in the discussion of several levels of simplification that are possible in this context.
Noise analysis of a nonlinear microwave circuit driven by a noisy sinusoidal source (1992)

Abstract The Letter introduces a general algorithm for the noise analysis of a nonlinear circuit operated in large‐signal time‐periodic conditions and fed by a noisy sinusoidal source. The algorithm is based on the piecewise harmonic‐balance technique, and thus retains all the typical advantages of frequency‐domain simulation. The statistical description of the noisy source, which is required to make a rigorous analysis possible, is discussed in detail. It is also shown that quite acceptable, though approximate, results can be derived on the basis of reduced statistical information consisting of the easily measurable PM and AM noise only. © 1992 John Wiley & Sons, Inc.
Unified architecture for divide and conquer based tridiagonal system solvers (1994)

The solution of tridiagonal systems is a topic of great interest in many areas of numerical analysis. Several algorithms have recently been proposed for solving triadiagonal systems based on the Divide and Conquer (DC) strategy. In this work we propose a unified parallel architecture for DC algorithms which present the data flows of the Successive Doubling, Recursive Doubling and Parallel Cyclic Reduction methods. The architecture is based in the perfect unshuffle permutation, which transforms these data flows into a constant geometry one. The partition of the data arises in a natural manner, giving way to a systolic data flow with a wired control section. We conclude that the constant geometry Cyclic Reduction architecture is the most appropriate one for solving tridiagonal systems and, from the point of view of integration in VLSI technology, is the one which uses the least amount of area and the smallest number of pins.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Interferenzoptische Kraftsensoren - eine neue Konzeption für die Kraftmeß- und Wägetechnik / Optical interference force sensors - a new conception for force-measuring and weighing techniques (1985)

Article Interferenzoptische Kraftsensoren - eine neue Konzeption für die Kraftmeß- und Wägetechnik / Optical interference force sensors - a new conception for force-measuring and weighing techniques was published on September 1, 1985 in the journal tm - Technisches Messen (volume 52, issue 9).
Dependence of the Capacitive Deionization Performance on Potential of Zero Charge Shifting of Carbon Xerogel Electrodes during Long-Term Operation (2014)

In order to examine the reliability of carbon xerogel (CX) materials for capacitive deionization (CDI), long-term operation of a CDI cell with CX electrodes was performed in a dilute NaCl solution. During operation at 1.2/0 V, the deionization performance gradually degraded, and a growing inversion peak formed at the beginning of each adsorption step. When the polarity of the electrode was reversed, the use of −1.2/0 V significantly boosted deionization performance. However, this enhancement was not sustained with continued cycling. In this study, we also reported the use of a four-electrode cell, in which the potential distribution for a pair of electrodes could be measured, and the potential of zero charge (PZC) for a single electrode could be located. Based upon the PZC location for the used electrodes with respect to the corresponding potential distribution, performance variation and the formation of the inversion peak for long-term CDI operation were interpreted. In addition, N2 adsorption-desorption measurements and surface morphology examinations indicated that there was little variation in the porosity of the cycled electrodes with long-term operation.