gebhart/patrepeval huggingface dataset:
Ultra-High Temperature Ceramic Composites for Leading Edges (2003)

Ultra-high temperature ceramics (UHTC) have performed unreliably due to material flaws and attachment design. These deficiencies are brought to the fore by the low fracture toughness and thermal shock resistance of UHTC. If these deficiencies are overcome, we are still faced with poor oxidation resistance as a limitation on UHT applicability to reusable launch vehicles. We have been addressing the deficiencies of UHTC for the past two years via a small task at GRC that is in the Airframe part of the Next Generation Launch Technology Program. Our focus is on composite constructions and functional grading to address the mechanical issues and on composition modification to address the oxidation issue. The progress on approaches to improving oxidation resistance by alloying and functional grading will be reported. In particular, initial tests of tantalum additions have shown potential for major improvement. Less promising results of additional tests at higher temperatures will be presented. Two fabrication approaches are being pursued to produce carbon fiber reinforced UHTC composites: prepregging and rigid perform infiltration. Fabrication procedures and microstructures for composites will be reported.
Uptake/Efflux Transport of Tramadol Enantiomers and<i>O</i>‐Desmethyl‐Tramadol: Focus on<i>P</i>‐Glycoprotein (2009)

The analgesic effect of tramadol (TMD) results from the monoaminergic effect of its two enantiomers, (+)-TMD and (-)-TMD as well as its opioid metabolite (+)-O-desmethyl-tramadol (M1). P-glycoprotein (P-gp) might be of importance in the analgesic and tolerability profile variability of TMD. Our study investigated the involvement of P-gp in the transepithelial transport of (+)-TMD, (-)-TMD and M1, using a Caco-2 cell monolayer model. The bidirectional transport of racemic TMD and M1 (1-100 microM) across the monolayers was investigated at two pH conditions (pH 6.8/7.4 and 7.4/7.4) in the presence and absence of P-gp inhibitor cyclosporine A (10 microM) and assessed with the more potent and specific P-gp inhibitor GF120918 (4 microM). Analytical quantification was performed by liquid chromatography coupled to the fluorescence detector. A net secretion of (+)-TMD, (-)-TMD and M1 was observed when a pH gradient was applied (TR: P(app)(B - A)/P(app)(A - B): 1.8-2.7; P < 0.05). However, the bidirectional transport of all compounds was equal in the non-gradient system. In the presence of P-gp inhibitors, a slight but significant increase of secretory flux was observed (up to 26%; P < 0.05) at both pH conditions. In conclusion, (+)-TMD, (-)-TMD and M1 are not P-gp substrates. However, proton-based efflux pumps may be involved in limiting the gastrointestinal absorption of TMD enantiomers as well as enhancing TMD enantiomers and M1 renal excretion. A possible involvement of uptake carriers in the transepithelial transport of TMD enantiomers and M1 is suggested.
1,2,4-Oxadiazoles--IV. Synthesis and Pharmacological Properties of a Series of Substituted Aminoalkyl-1,2,4-oxadiazoles (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,2,4-Oxadiazoles--IV. Synthesis and Pharmacological Properties of a Series of Substituted Aminoalkyl-1,2,4-oxadiazolesG. Palazzo, M. Tavella, G. Strani, and B. SilvestriniCite this: J. Med. Chem. 1961, 4, 2, 351–367Publication Date (Print):September 1, 1961Publication History Published online1 May 2002Published inissue 1 September 1961https://pubs.acs.org/doi/10.1021/jm50018a009https://doi.org/10.1021/jm50018a009research-articleACS PublicationsRequest reuse permissionsArticle Views434Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Solid Wastes and Residues (1978)

This discussion of solid wastes and residues is restricted to the materials that are predominantly organic in nature. Included are municipal refuse, scrap tires, agricultural residues, and forestry residues as well as organic sludges (mainly from wastewater treatment). The distinction between the terms "solid waste" and "residue" may be made precise by definition. Residues are defined here as solid by-products that have some positive value or represent no cost for disposal. These materials that represent a disposal cost are defined as solid wastes. These definitions, however, do not allow simple classification. For many types of materials, local market conditions are quite variable and the material may fall into both categories depending on the specific site, the season of the year, or the state of the economy.
The PTEN pathway in T <sub>regs</sub> is a critical driver of the suppressive tumor microenvironment (2015)

The tumor microenvironment is profoundly immunosuppressive. We show that multiple tumor types create intratumoral immune suppression driven by a specialized form of regulatory T cell (Treg) activation dependent on the PTEN (phosphatase and tensin homolog) lipid phosphatase. PTEN acted to stabilize Tregs in tumors, preventing them from reprogramming into inflammatory effector cells. In mice with a Treg-specific deletion of PTEN, tumors grew slowly, were inflamed, and could not create an immunosuppressive tumor microenvironment. In normal mice, exposure to apoptotic tumor cells rapidly elicited PTEN-expressing Tregs, and PTEN-deficient mice were unable to maintain tolerance to apoptotic cells. In wild-type mice with large established tumors, pharmacologic inhibition of PTEN after chemotherapy or immunotherapy profoundly reconfigured the tumor microenvironment, changing it from a suppressive to an inflammatory milieu, and tumors underwent rapid regression. Thus, the immunosuppressive milieu in tumors must be actively maintained, and tumors become susceptible to immune attack if the PTEN pathway in Tregs is disrupted.
Derivation of a nonlinear variance equation and its application to SOI technology (2000)

An analytic nonlinear equation for variance was derived along with a method based on response surface mapping techniques to calculate the variance using the proposed equation. The technique was applied to the threshold voltage of a 0.1-/spl mu/m silicon-on-insulator MOS device, and the variance value obtained was verified using Monte Carlo simulation. The threshold voltage dependence upon active-layer thickness was found to be highly nonlinear due to the device's going from the fully depleted to the partially depleted regime. Analysis of the variance showed that the effect of the nonlinear terms (18.7%) is more important than the effect of the mixed term (-0.7%) and almost as important as the contribution of the second most dominant input-process parameter (23.6%). This illustrates the importance of the proposed nonlinear equation.
A real-time tracking system for in vivo endofunctional capsule using magnetic sensors (2012)

This paper presents a real-time magnetic tracking system to be used for tracking an endofunctional capsule intended to aid in the delivery of biomarkers to specific areas in the gastrointestinal (GI) tract. Magnetic technology is chosen due to its significant advantages over others like RF and Ultrasonics. The tracking system is designed to be used with eight magnetic sensors making it less complex than the other proposed systems. The paper describes a new mathematical model which is more accurate than the existing ones, a linear tracking algorithm and system's performance evaluation for three sensor configurations. The algorithm copes with the problem of magnetic field strength drop due to varying orientation of magnet. The minimum average error obtained is 1.37cm/6.85% in a 20×20×20 cm(3) volume for two dimensional sensor configuration.
Wiring, Conundrums, Topology (1988)

Steiner is not, however, finally unsympathetic to the MLM project, as the unravelling of his further, broader, and perhaps expectable objections shows.
Discovery of Meaningful Rules in Time Series (2015)

The ability to make predictions about future events is at the heart of much of science; so, it is not surprising that prediction has been a topic of great interest in the data mining community for the last decade. Most of the previous work has attempted to predict the future based on the current value of a stream. However, for many problems the actual values are irrelevant, whereas the shape of the current time series pattern may foretell the future. The handful of research efforts that consider this variant of the problem have met with limited success. In particular, it is now understood that most of these efforts allow the discovery of spurious rules. We believe the reason why rule discovery in real-valued time series has failed thus far is because most efforts have more or less indiscriminately applied the ideas of symbolic stream rule discovery to real-valued rule discovery. In this work, we show why these ideas are not directly suitable for rule discovery in time series. Beyond our novel definitions/representations, which allow for meaningful and extendable specifications of rules, we further show novel algorithms that allow us to quickly discover high quality rules in very large datasets that accurately predict the occurrence of future events.
Der Zeichenunterricht einst und jeßt (1920)

Wer es heutzutage unternimmt, eine Arbeit üher den Zeichenunterricht zu veröffentlichen, gerät leicht in Gefahr, Oftgehörtes zu wiederholen. Man konnte getrost die Hälfte der vielen Lehrgänge und Vorlagewerke, die alljährlich neu erscheinen, ausschalten, ohne dem literarischen Bestand in seinem inneren Reichtum nennenswerten Abbruch zugefügt zu haben.
Active Terahertz metamaterial devices (2010)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Spironolactone Increases Nitric Oxide Bioactivity, Improves Endothelial Vasodilator Dysfunction, and Suppresses Vascular Angiotensin I/Angiotensin II Conversion in Patients With Chronic Heart Failure (2000)

Spironolactone improves endothelial dysfunction, increases NO bioactivity, and inhibits vascular Ang I/Ang II conversion in patients with heart failure, providing novel mechanisms for its beneficial effect on cardiovascular mortality.
Automated face swapping and its detection (2017)

Face has been used as one of the mainstream manners for user identification. However, with the popularity of face-swapping apps, it takes only a few seconds to change the faces between two facial images. Such swapped results, when using improperly or carelessly, might create some security issues in certain applications. This paper is the first work to address the importance of this issue and discusses the feasibility to achieve an automated face swapping detection through machine learning. Several approaches are tested on a face swapping database derived from a face benchmarking repository. The best solution in the experiments achieved a detection accuracy of over 92%.
Post-processing approach for radiometric self-calibration of video (2013)

We present a novel data-driven technique for radiometric self-calibration of video from an unknown camera. Our approach self-calibrates radiometric variations in video, and is applied as a post-process; there is no need to access the camera, and in particular it is applicable to internet videos. This technique builds on empirical evidence that in video the camera response function (CRF) should be regarded time variant, as it changes with scene content and exposure, instead of relying on a single camera response function. We show that a time-varying mixture of responses produces better accuracy and consistently reduces the error in mapping intensity to irradiance when compared to a single response model. Furthermore, our mixture model counteracts the effects of possible nonlinear exposure-dependent intensity perturbations and white-balance changes caused by proprietary camera firmware. We further show how radiometrically calibrated video improves the performance of other video analysis algorithms, enabling a video segmentation algorithm to be invariant to exposure and gain variations over the sequence. We validate our data-driven technique on videos from a variety of cameras and demonstrate the generality of our approach by applying it to internet video.
Characterization of a leukotriene D4 receptor in guinea pig lung. (1983)

[3H]Leukotriene D4 was found to bind, in a saturable manner and with exceedingly high affinity, to a membrane preparation from guinea pig lung. Measurement of saturation at equilibrium yielded Kd values of 5.46 +/- 0.31 X 10(-11) M at 20 degrees C and 2.12 +/- 0.37 X 10(-10) M at 0 degree C while the numbers of binding sites (Bmax) were 384 +/- 34 and 302 +/- 44 fmol/mg of protein at 20 and at 0 degree C, respectively. The time courses of both association and dissociation were slow but the rate of dissociation was accelerated by either NaCl or GTP. Binding was enhanced by Ca2+, Mg2+, and Mn2+ and inhibited by Na+ but not by Li+ or K+, suggesting that the binding of leukotriene D4 may be regulated by ions. Leukotriene E4, but not leukotriene C4, had a high affinity for the putative receptor, consistent with the pharmacological evidence that the actions of leukotrienes D4 and E4 are mediated by a receptor distinct from that for leukotriene C4. Affinities of stereoisomers and related compounds for the leukotriene D4 binding sites closely paralleled their contractile activities in guinea pig lung parenchymal strips. In addition, the antagonist of slow-reacting substance of anaphylaxis, FPL 55712, inhibited the binding of [3H]leukotriene D4 with a Ki value of 1 X 10(-7) M, which is in agreement with reported Kb values obtained in pharmacological studies.
Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films (2021)

The abundance of plant-derived proteins, as well as their biodegradability and low environmental impact make them attractive polymeric feedstocks for next-generation functional materials to replace current petroleum-based systems. However, efforts to generate functional materials from plant-based proteins in a scalable manner have been hampered by the lack of efficient methods to induce and control their micro and nanoscale structure, key requirements for achieving advantageous material properties and tailoring their functionality. Here, we demonstrate a scalable approach for generating mechanically robust plant-based films on a metre-scale through controlled nanometre-scale self-assembly of water-insoluble plant proteins. The films produced using this method exhibit high optical transmittance, as well as robust mechanical properties comparable to engineering plastics. Furthermore, we demonstrate the ability to impart nano- and microscale patterning into such films through templating, leading to the formation of hydrophobic surfaces as well as structural colour by controlling the size of the patterned features.
The universal ancestor (1998)

A genetic annealing model for the universal ancestor of all extant life is presented; the name of the model derives from its resemblance to physical annealing. The scenario pictured starts when "genetic temperatures" were very high, cellular entities (progenotes) were very simple, and information processing systems were inaccurate. Initially, both mutation rate and lateral gene transfer levels were elevated. The latter was pandemic and pervasive to the extent that it, not vertical inheritance, defined the evolutionary dynamic. As increasingly complex and precise biological structures and processes evolved, both the mutation rate and the scope and level of lateral gene transfer, i.e., evolutionary temperature, dropped, and the evolutionary dynamic gradually became that characteristic of modern cells. The various subsystems of the cell "crystallized," i.e., became refractory to lateral gene transfer, at different stages of "cooling," with the translation apparatus probably crystallizing first. Organismal lineages, and so organisms as we know them, did not exist at these early stages. The universal phylogenetic tree, therefore, is not an organismal tree at its base but gradually becomes one as its peripheral branchings emerge. The universal ancestor is not a discrete entity. It is, rather, a diverse community of cells that survives and evolves as a biological unit. This communal ancestor has a physical history but not a genealogical one. Over time, this ancestor refined into a smaller number of increasingly complex cell types with the ancestors of the three primary groupings of organisms arising as a result.
A 16–28-W 92.8%-Efficiency Monolithic Quasi-Resonant LED Driver With Constant-Duty-Ratio Frequency Regulator (2015)

This brief presents a monolithic high-voltage light-emitting diode (LED) driver for lighting applications. The LED driver is able to operate at high switching frequency because large switching loss is eliminated by zero-voltage switching. Inductor values are therefore reduced. A constant-duty-ratio frequency regulator (CDFR) is proposed to regulate the LED current, and the small signal characteristics of the proposed LED driver with CDFR are analyzed. The proposed design, including the controller and power transistor, was fabricated in MagnaChip 0.35-μm 700-V bipolar-CMOSLDMOS process. The LED driver with 2 × 3.9 μH inductors switches at around 5.4 MHz and powers up 16-28 1-W LEDs. Experimental results show that the LED driver achieves peak efficiency of 92.8% within the input voltage range of 55-120 V.
The structure of neutral protease from <i>Bacillus cereus</i> at 0.2‐nm resolution (1992)

The crystal structure of the neutral protease from Bacillus cereus has been refined to an R factor of 17.5% at 0.2-nm resolution. The enzyme, an extracellular metalloendopeptidase, consists of two domains and binds one zinc and four calcium ions. The structure is very similar to that of thermolysin, with which the enzyme shares 73% amino-acid sequence identity. The active-site cleft between the two domains is wider in neutral protease than in thermolysin. This suggests the presence of a flexible hinge region between the two domains, which may assist enzyme action. The high-resolution analysis allows detailed examination of possible causes for the difference in thermostability between neutral protease and thermolysin.
Generation of diamond nuclei by electric field in plasma chemical vapor deposition (1991)

Generation of diamond nuclei has been realized on a silicon mirror surface in plasma chemical vapor deposition. Prior to the normal diamond growth process, a predeposition process of several minutes duration was introduced in which a high methane fraction in the feed gas was used and in which a negative bias voltage was applied to the substrate. This resulted in an enormous enhancement of the generation of diamond nuclei. For the onset of diamond nucleation the minimum voltage was −70 V and the minimum methane fraction in the methane-hydrogen feed gas was 5%. Density of a diamond nuclei as high as 1010/cm2 was attained with this method.
Concentration of Docosahexaenoic Acid (DHA) by Selective Alcoholysis Catalyzed by Lipases (2012)

Abstract The aim of this work was to obtain acylglycerols from tuna oil (23 % weight DHA) rich in docosahexaenoic acid (DHA) by selective ethanolysis, catalyzed by lipases. First, seven immobilized lipases were tested and the best DHA concentration and recovery in the acylglycerol fraction were attained with Lipozyme TL IM ® from Thermomyces lanuginosus , Lipozyme RM IM from Rhizomucor miehei , and lipase from Thermomyces lanuginosus immobilized on Immobead 150. As it is the cheapest, Lipozyme TL IM ® was selected to optimize the reaction conditions. The influence of temperature, reaction time, and ethanol/oil and lipase/oil ratios were studied. Under the optimized conditions (35 °C, ethanol/oil molar ratio 2.3, lipase/oil ratio 5 % weight and 48 h) and for a 56 % conversion, acylglycerols were obtained with a 45 % DHA concentration and 90 % recovery. In these optimized conditions the reaction was scaled up to 766 g of tuna oil and carried out in a batch stirred tank reactor, with the lipase contained in a cartridge filter attached to the stirring rod. The results were similar to those obtained on the smaller scale. The DHA‐enriched acylglycerols were separated from the ethyl esters by evaporation of the latter in a short‐path vacuum distiller, where the influence of distillation temperature was studied. At 170 °C DHA‐rich acylglycerols (44 % DHA) were recovered in the residue with 94.5 % purity and 72 % recovery.
Neuroprotective Effects of Pyridoxal Phosphate and Pyridoxal against Ischemia in Monkeys (2001)

Previously, in monkeys undergoing 20 min whole brain ischemia we demonstrated that the activated calpain-induced lysosomal disruption with the resultant leakage of cathepsins B and L, causes neuronal death in the cornu Ammonis (CA) 1 sector on day 5. Selective cathepsin inhibitors significantly protected ischemic CA1 neurons from delayed necrosis. Recently, pyridoxal phosphate (PLP) and pyridoxal (hydrochloride) (PL) were demonstrated to inhibit cathepsins B and L in vitro, because the active aldehyde at position 4 of the pyridine ring has an affinity for the active site -SH of cysteine residues of cathepsins. Here, we studied whether PLP and PL can, in vivo, protect monkey CA1 neurons from ischemic insult. In monkeys undergoing 20 min whole brain ischemia, 15 mg/kg body weight/day of drugs were intravenously injected for 10 days before and after the ischemic insult. Histological analysis of the surviving CA1 neurons was done using the hippocampus resected on day 5 after ischemia. For PLP or PL, approximately 17% (P = 0.0639) or 54% (P < 0.0001) of the total population (100%) of control CA1 neurons were, respectively, saved from the ischemia-induced neuronal death, showing a remarkable contrast to the surviving neurons (approximately 3.9%) in non-treated monkeys. These data suggested that PL (perhaps PLP intracellularly) is useful as a novel neuroprotectant in primates.