gebhart/patrepeval huggingface dataset:
Stochastic progressive photon mapping (2009)

This paper presents a simple extension of progressive photon mapping for simulating global illumination with effects such as depth-of-field, motion blur, and glossy reflections. Progressive photon mapping is a robust global illumination algorithm that can handle complex illumination settings including specular-diffuse-specular paths. The algorithm can compute the correct radiance value at a point in the limit. However, progressive photon mapping is not effective at rendering distributed ray tracing effects, such as depth-of-field, that requires multiple pixel samples in order to compute the correct average radiance value over a region. In this paper, we introduce a new formulation of progressive photon mapping, called stochastic progressive photon mapping, which makes it possible to compute the correct average radiance value for a region. The key idea is to use shared photon statistics within the region rather than isolated photon statistics at a point. The algorithm is easy to implement, and our results demonstrate how it efficiently handles scenes with distributed ray tracing effects, while maintaining the robustness of progressive photon mapping in scenes with complex lighting.
Epinephrine: A Potential Neurotransmitter in Retina (1983)

Dopamine (DA), norepinephrine (NE), and epinephrine (EPI) are present in rat retina. DA is the major catecholamine, whereas NE and EPI represent approximately 5% of the DA content. DA is contained in a subpopulation of amacrine cells and has been the subject of numerous studies. We investigated the origin and properties of NE and EPI in retina. Following superior cervical ganglionectomy, there was a decrease in NE content, but no decrease in EPI or phenylethanolamine-N-methyltransferase (PNMT) activity. PNMT in retina has many of the substrate-specificity and inhibitor-sensitivity characteristics of other tissues. Enzyme activity is enhanced in newborn rats by treatment with dexamethasone. Exposure to a lighted environment increases retinal EPI in normal and superior cervical ganglionectomized rats. EPI content increased for more than 2 h in a lighted environment. We conclude that most of the NE is contained within the sympathetic neurons that innervate the eye from the superior cervical ganglion, whereas EPI is contained in retinal elements that are responsive to photic stimulation.
Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner (2017)

A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms. Conventional CT, gold K-edge, iodine and water images were produced and demonstrated accurate discrimination and quantification of gold and iodine concentrations in a phantom containing mixtures of the contrast agents. In vivo experiments were performed using New Zealand White rabbits at several times points after injections of AuNP and iodinated contrast agents. We found that the contrast material maps clearly differentiated the distributions of gold and iodine in the tissues allowing quantification of the contrast agents' concentrations, which matched their expected pharmacokinetics. Furthermore, rapid, repetitive scanning was done, which allowed measurement of contrast agent kinetics with high temporal resolution. In conclusion, a clinical scale, high count rate SPCCT system is able to discriminate gold and iodine contrast media in different organs in vivo.
Enzyme replacement therapy for mucopolysaccharidosis VI from 8 weeks of age–a sibling control study (2009)

Mucopolysaccharidosis type VI (MPS VI) is a progressive, multisystem disorder caused by a deficiency of the lysosomal enzyme N-acetylgalactosamine-4-sulphatase (ASB). Enzyme replacement therapy (ERT) has been shown to clinically benefit affected individuals greater than 6 years of age. This case control study of affected siblings assessed the safety, efficacy and benefits of ERT in children less than 5 years of age. Siblings, aged 8 weeks and 3.6 years, were treated weekly with 1 mg/kg recombinant human N-acetylgalactosamine-4-sulphatase (rhASB) with an end-point of 3.6 years. Clinical and biochemical parameters were monitored to assess the benefits of ERT. The treatment was well tolerated by both siblings. In the younger sibling, ERT was associated with the absence of the development of scoliosis and preserved joint movement, cardiac valves and facial morphology. The older sibling had a marked improvement in joint mobility and cardiac valve pathology and scoliosis slowed or stabilized. Corneal clouding and progressive skeletal changes were observed despite treatment. This study demonstrated a clear benefit of early initiation of ERT to slow or prevent the development of significant pathological changes of MPS VI. These results indicate that the earlier ERT is started, the greater the response.
Antibody-conjugated soybean oil-filled calcium phosphate nanoshells for targetted delivery of hydrophobic molecules (2006)

Hollow calcium phosphate nanoparticles capable of encapsulating poorly water-soluble molecules were produced by self-assembly. Previously reported were solid calcium phosphate nanoparticles and water-filled calcium phosphate nanocapsules suited for encapsulating mostly hydrophilic, but not hydrophobic compounds. Here, calcium phosphate was deposited around 100 nm diameter, 1,2-dioleoyl-sn-glycero-3-phosphate stabilized soybean oil nanoemulsions using either calcium chloride or NaOH titrations to achieve shell thickness between 20-70 nm. The surface was functionalized with carboxylic acid via the addition of carboxyethylphosphonic acid to attach Molecular Probes AB-594C antibody using sulpho-n-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride with an efficiency of approximately 70%, while retaining near complete antibody function. Hydrophobic pyrene was encapsulated with an efficiency of 95%, at concentrations much higher than its water solubility limit, and exhibited spectral features characteristic of a hydrophobic environment. These materials can be used in the targeted delivery of many useful, yet poorly water-soluble pharmaceutical and nutraceutical compounds.
Escherichia coli 30 S ribosomal proteins uniquely required for assembly. (1975)

Two 30 S ribosomal proteins from Escherichia coli have been found to be uniquely required for assembly of 30 S ribosomal subunits. 30 S ribosomes were reconstituted in vitro from 16 S RNA and a mixture of purified 30 S ribosomal proteins (sigma Si). In the absence of S16, sigmaSi-S16 particles were slowly assembled wich had physical and functional properties similar to complete particles (sigmaSi). The results indicate that S16 affects the rate of 30 S ribosome assembly, but does not appear to be directly involved in any known ribosomal function. Particles assembled in the absence of S18 (sigmaSi-S18) had high activity in poly(U)-directed polyphenylalanine synthesis but lost considerable activity upon isolation or purification. The loss of activity could be attributed primarily to the loss of proteins S11 and S21. S18 appears to have a major role in the stabilization of ribosome structure, especially the binding of proteins S11 and S21, and does not appear to be directly required for activity in poly(U)-directed polyphenylalanine synthesis. However, it is possible that S18 has some functional role which is not required for polyphenylalanine synthesis.
Design of SAW filters on langasite (1999)

Due to good temperature stability and moderately high electromechanical coupling coefficient langasite (Li <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> or LGS) is known as a promising material for SAW devices. The characteristics of the Rayleigh wave propagation on LGS have been studied fairly well. However, no design of SAW devices on LGS suitable for modern communication systems has been reported as yet. In this paper, transversal filters on LGS based on bidirectional interdigital transducers, and low-loss filters on LGS based on natural single phase unidirectional transducers (NSPUDT), are described. The filters on LGS have exhibited better electrical parameters than their analogues on quartz and lithium tantalate.
Erratum: High current ion source [Appl. Phys. Lett. <b>4</b> <b>7</b>, 358 (1985)] (1985)

First Page
Prediction of transition from cognitive impairment to senile dementia: a prospective, longitudinal study (2003)

The models derived from these two longitudinal studies provide an empirical basis for the selection of tests for the definition of mild cognitive impairment of the Alzheimer type (MCI-A). The small set of tests derived are suitable for use in general practice.
The xanthophyll cycle, its regulation and components (1997)

During the last few years much interest has been focused on the photoprotective role of zeaxanthin. In excessive light zeaxanthin is rapidly formed in the xanthophyll cycle from violaxanthin, via the intermediate antheraxanthin, a reaction reversed in the dark. The role of zeaxanthin and the xanthophyll cycle in photoprotection, is based on fluorescence quenching measurements, and in many studies a good correlation to the amount of zeaxanthin (and antheraxanthin) has been found. Other suggested roles for the xanthophylls involve, protection against oxidative stress of lipids, participation in the blue light response, modulation of the membrane fluidity and regulation of abscisic acid synthesis. The enzyme violaxanthin de-epoxidase has recently been purified from spinach and lettuce as a 43-kDa protein. It was found as 1 molecule per 20-100 electron-transport chains. The gene has been cloned and sequenced from Lactuca sativa, Nicotiana tabacum and Arabidopsis thaliana. The transit peptide was characteristic of nuclear-encoded and lumen-localized proteins. The activity of violaxanthin de-epoxidase is controlled by the lumen pH. Thus, below pH 6.6 the enzyme binds to the thylakoid membrane. In addition ascorbate becomes protonated to ascorbic acid (pKa= 4.2) the true substrate (Km= 0.1 mM) for the violaxanthin de-epoxidase. We present arguments for an ascorbate transporter in the thylakoid membrane. The enzyme zeaxanthin epoxidase requires FAD as a cofactor and appears to use ferredoxin rather than NADPH as a reductant. The zeaxanthin epoxidase has not been isolated but the gene has been sequenced and a functional protein of 72.5 kDa has been expressed. The xanthophyll cycle pigments are almost evenly distributed in the thylakoid membrane and at least part of the pigments appears to be free in the lipid matrix where we conclude that the conversion by violaxanthin de-epoxidase occurs.
The 5′ untranslated region of the <i>At‐P5R</i> gene is involved in both transcriptional and post‐transcriptional regulation (2001)

The steady-state level of transcripts coding for the pyrroline-5-carboxylate reductase of Arabidopsis (At-P5R) increased under salt and heat stress, mainly because of an enhanced mRNA stability. However, the At-P5R protein level was not induced, and its translation was inhibited at initiation stage and probably also at later stages. Replacement of the 5' untranslated region (5'UTR) and beta-glucuronidase (gus) fusion analysis revealed that the first 92 bp region of the At-P5R 5'UTR was sufficient to mediate transcript stabilization and translation inhibition during salt and heat stresses. Furthermore, the first 92 bp region of the At-P5R 5'UTR was also involved in transcription efficiency in a promoter-dependent manner. The results demonstrated that the stress regulation of At-P5R is complex and involves the 5'UTR which acts at three levels, partly in opposing directions.
Robust bayesian model Selection (2013)

Ministry of Education, Singapore under its Academic Research Funding Tier 2
Recursive functions of symbolic expressions and their computation by machine, Part I (1960)

A programming system called LISP (for LISt Processor) has been developed for the IBM 704 computer by the Artificial Intelligence group at M.I.T. The system was designed to facilitate experiments with a proposed system called the Advice Taker, whereby a machine could be instructed to handle declarative
Biocompatibility of poly(ethylene glycol)‐based hydrogels in the brain: An analysis of the glial response across space and time (2010)

Poly(ethylene glycol) or PEG-based hydrogels provide a useful methodology for tissue engineering and the controlled-release of drugs within the central nervous system (CNS). To be successful, the local neuroinflammatory response to an implant must be well understood. Toward this end, the focus was to examine the localized recruitment and activation of microglia and astrocytes following implantation of PEG-based hydrogels in the brain. Because they are of clinical relevance and may impact brain tissue differently, hydrogels with different mass loss profiles were examined. At all time points, a needle penetration in sham animals evoked a greater astrocytic response than hydrogel conditions. The astrocyte response that ensued varied with degradation rate. An attenuated response was present in more slowly degrading and nondegrading conditions. Relative to sham, hydrogel conditions attenuated the acute microglial response during the week after implant. By 56 days, microglial levels in shams decreased below the observed response in slowly degrading and nondegradable gels, which remained constant overtime. Although the inflammatory response to PEG-based hydrogels was complex depending on degradation rates, the magnitude of the acute microglia response and the long-term astrocyte response were attenuated suggesting the use of these materials for drug and cell delivery to the CNS.
Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion (2020)

The molecular basis for the severity and rapid spread of the COVID-19 disease caused by SARS-CoV-2 is largely unknown. ORF8 is a rapidly evolving accessory protein that has been proposed to interfere with immune responses. The crystal structure of SARS-CoV-2 ORF8 was determined at 2.04 Å resolution by x-ray crystallography. The structure reveals a ~60 residue core similar to SARS-CoV ORF7a with the addition of two dimerization interfaces unique to SARS-CoV-2 ORF8. A covalent disulfide-linked dimer is formed through an N-terminal sequence specific to SARS-CoV-2, while a separate non-covalent interface is formed by another SARS-CoV-2-specific sequence, <sub>73</sub> YIDI <sub>76</sub> . Together the presence of these interfaces shows how SARS-CoV-2 ORF8 can form unique large-scale assemblies not possible for SARS-CoV, potentially mediating unique immune suppression and evasion activities.
Distributed Control to Improve Performance of Thermoelectric Coolers (2004)

Thermoelectric coolers (TECs) have become potential solutions for chip cooling applications. However, the scope of TEC applicability is limited because of poor efficiency that is largely governed by material properties. This low efficiency causes increased heat production resulting in a very narrow band in which the TEC is effective. Since TECs are cooling units composed of numerous individual cooling elements, or thermocouples, the operating efficiency can be improved by implementing distributed control of the individual couples. Distributed control is a system for allowing each couple to be powered depending on the localized heat load. Distributed control would allow for increased cooling in hot spots while minimizing excess heat generated by the TEC in areas where it is not needed. The preliminary results suggest that this type of control may be feasible, and would result in a significant increase in the TEC effectiveness. The current model considers lateral heat conduction in the chip, as well as variable control of the individual thermocouples proportional to heat load. Results indicate that a 2-fold increase in COP is possible with independently controlled couples compared to a single cooler.
FORMATION OF BRAGG GRATINGS IN GERMANIUM DOPED OPTICAL FIBERS USING A PRISM INTERFEROMETER (1991)

Bragg gratings have been written in Germanium doped core silica fibers by transversally exposing the fibers to fringe patterns produced by a pair of coherent U.V. pulsed beams combined inside a prism interferometer. The transmission spectra of the gratings have been recorded at various times of irradiation. The drop in transmission near resonance wavelength may be as large as 100%, depending on the experimental conditions of the writing experiment. The thermal annealing behavior of different gratings shows that the evolution of the fiber transmittivity recovery versus temperature depends upon the number and the energy of the laser pulses applied to form the grating and upon the nature of the fiber.
Guidelines for prescribing melatonin (1998)

Although compelling logic suggests that melatonin may be effective for a variety of disorders, there are few empirical clinical studies. The optimal dose of melatonin is not clear; most studies have used doses that produce supraphysiological blood levels. The timing of melatonin administration is important. Melatonin has few immediate side-effects except drowsiness, but the effects of chronic administration are unclear. Melatonin may be effective in reducing jet lag. In elderly patients with poor sleep and documented low melatonin production, melatonin may be helpful. In several studies, melatonin has been shown to shorten sleep latency. Further studies are needed to clarify the efficacy and safety of melatonin.
Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Receptor/PGRMC1 Subtype‐Selective Ligands (2016)

A novel structural class with high affinity and subtype selectivity for the sigma 2 receptor has been discovered. Preliminary structure-affinity relationship data are presented showing that 8-substituted 1,3,4,5-tetrahydro-1,5-methanobenzazepine (norbenzomorphan) derivatives elicit modest to high selectivity for the sigma 2 over the sigma 1 receptor subtype. Indeed, piperazine analogue 8-(4-(3-ethoxy-3-oxopropyl)piperazin-1-yl)-1,3,4,5-tetrahydro-1,5-methanobenzazepine-2-carboxylate (SAS-1121) is 574-fold selective for the sigma 2 over the sigma 1 receptor, thereby establishing it as one of the more subtype-selective sigma 2 binding ligands reported to date. Emerging evidence has implicated the sigma 2 receptor in multiple health disorders, so the drug-like characteristics of many of the selective sigma 2 receptor ligands disclosed herein, coupled with their structural similarity to frameworks found in known drugs, suggest that norbenzomorphan analogues may be promising candidates for further development into drug leads.
New plate medium for screening and presumptive identification of gram-negative urinary tract pathogens (1988)

A new selective, differential plating medium to screen the common gram-negative urinary tract pathogens is described. The medium combines adonitol fermentation, phenylalanine deaminase, and beta-glucuronidase tests and allows the indole and cytochrome oxidase tests to be performed directly from the plates. High-level agreement with individual conventional tests was recorded in comparative studies with 504 cultures of gram-negative rods. There was 100% agreement, except for the Providencia spp. indole spot test (61.6% agreement). Adonitol fermentation by Providencia species could not be determined. Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Pseudomonas aeruginosa were identified with a high efficiency (100, 85.7, 83.5, and 100% agreement, respectively) without further testing. There was 96% overall agreement for the 267 infected urine samples tested.
Toward a Theory of Stakeholder Identification and Salience: Defining the Principle of who and What Really Counts (1997)

Ronald K. Mitchell, Bradley R. Agle, Donna J. Wood, Toward a Theory of Stakeholder Identification and Salience: Defining the Principle of Who and What Really Counts, The Academy of Management Review, Vol. 22, No. 4 (Oct., 1997), pp. 853-886
Volatile components of roasted peanuts (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVolatile components of roasted peanutsJohn P. Walradt, Alan O. Pittet, Thomas E. Kinlin, Ranya. Muralidhara, and Anne. SandersonCite this: J. Agric. Food Chem. 1971, 19, 5, 972–979Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1 May 1971https://pubs.acs.org/doi/10.1021/jf60177a017https://doi.org/10.1021/jf60177a017research-articleACS PublicationsRequest reuse permissionsArticle Views592Altmetric-Citations114LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effective Use of Graph Convolution Network and Contextual Sub-Tree for Commodity News Event Extraction (2021)

Event extraction in commodity news is a less researched area as compared to generic event extraction. However, accurate event extraction from commodity news is useful in a broad range of applications such as understanding event chains and learning event-event relations, which can then be used for commodity price prediction. The events found in commodity news exhibit characteristics different from generic events, hence posing a unique challenge in event extraction using existing methods. This paper proposes an effective use of Graph Convolutional Networks (GCN) with a pruned dependency parse tree, termed contextual sub-tree, for better event extraction in commodity news. The event extraction model is trained using feature embeddings from ComBERT, a BERT-based masked language model that was produced through domain-adaptive pre-training on a commodity news corpus. Experimental results show the efficiency of the proposed solution, which outperforms existing methods with F1 scores as high as 0.90. Furthermore, our pre-trained language model outperforms GloVe by 23%, and BERT and RoBERTa by 7% in terms of argument roles classification. For the goal of reproducibility, the code and trained models are made publicly available 1 .
Studies of limitations to peak power and efficiency in diode lasers using extreme-double-asymmetric vertical designs (2016)

High power diode lasers with novel extreme-double-asymmetric epitaxial designs with increased modal confinement in the well Γ achieve high efficiency (50%) and powers (14 W) at high continuous wave heatsink temperature (75°C), attributed to the effective suppression of power saturation mechanisms. Prospects for increased performance via further increased Γ are analyzed.