gebhart/patrepeval huggingface dataset:
Storage lipid biosynthesis in microspore-derived Brassica napus embryos (1989)

Erucic acid, a fatty acid which is confined to the neutral lipids in developing seed cotyledons or rape, was chosen as a marker to study triacylglycerol (TAG) biosynthesis in a Brassica napus L. cv Reston microspore-derived embryo culture system. Accumulation and changes in acyl composition of TAGs during embryogenesis strongly paralleled that observed during seed development. Homogenates of 29-day cultured embryos were examined for the ability to incorporate erucoyl moieties into storage lipids. In the presence of {sup 14}C erucoyl CoA and various acceptors, including glycerol-3-phosphate (G3P), {sup 14}C erucic acid was rapidly incorporated into the TAG fraction. However, in contrast to studies with {sup 14}C oleoyl CoA, there was no measurable radioactivity in any Kennedy Pathway intermediates or within membrane lipid components. Analysis of the radiolabelled TAG species suggested that erucoyl moieties were incorporated into the sn-3 position by a highly active diacylglyercol acyltransferase.
The antigens of vesicular stomatitis virus. 3. Structure and immunogenicity of antigens derived from the virion by treatment with Tween and ether. (1967)

The infective component of vesicular stomatitis virus was purified by ammonium sulfate precipitation, differential ultracentrifugation and sucrose density gradient centrifugation and then treated with Tween-ether. This treatment reduced the infectivity of the preparation by ca. 4 logs but the complement-fixing activity and immunogenicity for guinea pigs was enhanced. Three fractions possessing complement-fixing activity and immunogenic activity were isolated from the disrupted virion by sucrose density gradient centrifugation: 1) a skeleton-like structure of about the same size as the virion but lacking the fringe structure and possessing a greater sedimentation coefficient than the virion, 2) rosettes with a sedimentation coefficient of 16 S and 3) material of about 3 to 6 S, which is presumably the fringe-like structures removed from the virion by the Tween-ether treatment.
Self-assembly of bilayers from double-chain fluorocarbon amphiphiles in aprotic organic solvents: thermodynamic origin and generalization of the bilayer assembly (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-assembly of bilayers from double-chain fluorocarbon amphiphiles in aprotic organic solvents: thermodynamic origin and generalization of the bilayer assemblyYuichi Ishikawa, Hiroaki Kuwahara, and Toyoki KunitakeCite this: J. Am. Chem. Soc. 1994, 116, 13, 5579–5591Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/ja00092a008https://doi.org/10.1021/ja00092a008research-articleACS PublicationsRequest reuse permissionsArticle Views768Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Viscosity Characteristics of Modified Bitumen (2012)

The effect of commercial additive Sasobit wax (S) on the viscosity characteristics of bitumen 60/70-penetration grade is yet to be fully understood. The viscosity of bitumen is the measure of its resistance to flow which affects workability, and resistance to deformation of the mixture. This study reviewed the bitumen modification process in relation to warm mix asphalt (WMA) technology, using S as a modifier. The study investigated the viscosity measurements of modified bitumen, using the Brookfield viscometer. The binders mixed with various percentage of the wax S 1%, 2%, 3%, 4%and 5 % were investigated. The results from the study showed the viscosity of the binder decreasing at higher temperatures while at midrange temperatures the viscosity increases with an increase in the additive. This study has provided a valuable data on the effect of the additive S on increasing the dynamic viscosity of the binder at low temperature and decreasing the kinematic viscosity at high temperature, been attributed to the presence of the S wax with high hydrocarbons molecular content in the binder, which is expected to improve the viscosity properties of the modified binder and enhance its resistance to deformation when used in warm asphalt concrete mixtures.
Filter Devices for Cerebral Protection during Carotid Angioplasty and Stenting (2003)

The risk of embolization during carotid artery stenting (CAS) has been the foremost reason for the cautious acceptance of this percutaneous alternative to carotid endarterectomy. To address this issue, numerous embolic protection devices are being evaluated as an adjunct to CAS for neuroprotection. Among the 3 main categories of these devices, distal filters, which trap embolic debris while maintaining distal cerebral perfusion, have attracted the most corporate interest. This review focuses on the emerging field of embolic protection filters for use in CAS.
North American Indigenous Women and Cultural Domination (1993)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Beatrice Medicine; North American Indigenous Women and Cultural Domination. American Indian Culture and Research Journal 1 January 1993; 17 (3): 121–130. doi: https://doi.org/10.17953/aicr.17.3.mutjt04g759437ll Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search
Contribution of Efflux Pumps, Porins, and β-Lactamases to Multidrug Resistance in Clinical Isolates of Acinetobacter baumannii (2013)

We investigated the mechanisms of resistance to carbapenems, aminoglycosides, glycylcyclines, tetracyclines, and quinolones in 90 multiresistant clinical strains of Acinetobacter baumannii isolated from two genetically unrelated A. baumannii clones: clone PFGE-ROC-1 (53 strains producing the OXA-58 β-lactamase enzyme and 18 strains with the OXA-24 β-lactamase) and clone PFGE-HUI-1 (19 strains susceptible to carbapenems). We used real-time reverse transcriptase PCR to correlate antimicrobial resistance (MICs) with expression of genes encoding chromosomal β-lactamases (AmpC and OXA-51), porins (OmpA, CarO, Omp33, Dcap-like, OprB, Omp25, OprC, OprD, and OmpW), and proteins integral to six efflux systems (AdeABC, AdeIJK, AdeFGH, CraA, AbeM, and AmvA). Overexpression of the AdeABC system (level of expression relative to that by A. baumannii ATCC 17978, 30- to 45-fold) was significantly associated with resistance to tigecycline, minocycline, and gentamicin and other biological functions. However, hyperexpression of the AdeIJK efflux pump (level of expression relative to that by A. baumannii ATCC 17978, 8- to 10-fold) was significantly associated only with resistance to tigecycline and minocycline (to which the TetB efflux system also contributed). TetB and TetA(39) efflux pumps were detected in clinical strains and were associated with resistance to tetracyclines and doxycycline. The absence of the AdeABC system and the lack of expression of other mechanisms suggest that tigecycline-resistant strains of the PFGE-HUI-1 clone may be associated with a novel resistance-nodulation-cell efflux pump (decreased MICs in the presence of the inhibitor Phe-Arg β-naphthylamide dihydrochloride) and the TetA(39) system.
Recent progress in immunopharmacology and therapeutic effects of polysaccharides. (1992)

Lentinan, a (1----3)-beta-D-glucan with (1----6)-beta-D-glucopyranoside branches and its related polysaccharides have marked antitumour activity in allogeneic, syngeneic and autochthonous primary hosts, suppress chemical and viral oncogenesis, and prevent cancer recurrence or metastasis after surgery. Results of the clinical application of lentinan have proven prolongation of life-span of the patients with advanced and recurrent stomach, colorectal and breast cancer with only little toxic side effect. These polysaccharides also increase host resistance to various kinds of bacterial, viral and parasitic infections including AIDS. Lentinan appears to represent Host Defence Potentiators (HDPs), which can restore or augment the ability of responsiveness of the host to lympho-cytokines or other intrinsic bioactive factors through maturation, differentiation or proliferation of the important cells for host defence mechanisms. That is, HDPs might make the physiological constitution highly cancer and infection-resistant, which may be a concept in Oriental Medicine, the fundamental principle of which is to regulate homeostasis of the whole body and to bring the diseased person to his normal state. HDPs such as lentinan are the most appropriate drugs to prevent cancer recurrence, or the manifestation of AIDS symptoms in HIV carriers.
Extending the dynamic range of nuclear pulse spectrometers (2008)

Using an innovative time-varying front-end electronics in conjunction with a bulky coaxial high-purity germanium detector, we were able to extend the range of the radionuclide spectra well beyond the analog to digital converter (ADC) saturation point. The electronics automatically conditions the signal for digital-filtering optimization if it is in the ADC voltage range and for time-over-threshold analysis if it exceeds the ADC range. A high spectroscopic resolution has been achieved in both operation ranges. An unprecedented wide energy range from 5 keV to 150 MeV of equivalent energy, or 90 dB, has been obtained using a single acquisition chain, while maintaining a high-energy resolution in the whole spectrum. For example, with an ADC range of 3 MeV a resolution has been obtained of 1.3/2.2 keV full width at half maximum on the 122/1332 keV gamma-ray lines of 57Co and 60Co, and of <0.4% in the time-over-threshold region, or for energy deposits beyond 3 MeV.
Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a Small Molecule Inhibitor of Jak2 Tyrosine Kinase Autophophorylation (2005)

The commercially available Jak2 inhibitor, alpha-cyano-3,4-dihydroxy-N-benzylcinnamide (AG490), has been used extensively to study Jak2 kinase function. While alpha-cyano-3,4-dihydroxy-N-benzylcinnamide is a potent Jak2 inhibitor, it can inhibit a number of other kinase signaling pathways as well. To circumvent this problem, we sought to identify novel small molecule inhibitors of Jak2 tyrosine kinase activity. For this, we constructed a homology model of the Jak2 kinase domain and identified solvent accessible pockets on the surface of the structure. Using the DOCK program, we tested 6451 compounds of known chemical structure in silico for their ability to interact with a pocket positioned adjacent to the activation loop. We attained the top seven scoring compounds from the National Cancer Institute and tested their ability to inhibit Jak2 autophosphorylation in vitro. Using Western blot analysis, we found that one of the compounds, 1,2,3,4,5,6-hexabromocyclohexane, was able to potently, and directly, inhibit Jak2 autophosphorylation. Characterization of this compound revealed that it inhibits Jak2 tyrosine autophosphorylation in both a time- and concentration-dependent manner. It greatly reduced growth hormone-mediated Jak2 autophosphorylation but did not block autophosphorylation of the epidermal growth factor receptor. Furthermore, doses as high as 100 muM were not toxic to cells as measured by their ability to exclude propidium iodide. As such, we believe that this compound could serve as a lead compound for a new generation of Jak2 inhibitors and, perhaps, be useful in elucidating the mechanisms of Jak2 kinase function.
Activity and Phylogenetic Composition of Proteolytic Bacteria in Mesophilic Fed-batch Garbage Composters (2004)

Crude extracts of extracellular enzymes were prepared from a solid waste-compost mixture (SCM) taken from two mesophilic fed-batch composting (FBC) reactors for garbage treatment, and were tested for protease activity with azocasein as the substrate. The protease activity was highest at a reaction temperature of 70°C and remained relatively high even at 90°C. The optimum pH for the activity was 7 to 10. There were a significant negative correlation between the protease activity and the moisture content in the FBC reactors when the extracts were prepared. Seventy-six strains of proteolytic bacteria were isolated quantitatively by the agar-plating method and identified phylogenetically by 16S rRNA gene sequencing. Most of the isolates were assigned to members of the phyla Actinobacteria, Bacteroidetes, and Firmicutes, especially those of the genera Bacillus, Cellulosimicrobium, and Ornithinococcus and an unaffiliated Cytophaga-like group. Inhibitor and zymography experiments showed that the proteolytic activities of the isolates belonging to the above-noted Gram-positive genera as well as of the SCM sample were inhibited by phenylmethylsulfonyl fluoride and that the isolates of Bacillus, Cellulosimicrobium, and the Cytophaga-like group excreted a protease similar to those from the SCM sample in electrophoretic mobility. The results of this study suggest that bacteria belonging to the phyla Actinobacteria and Firmicutes and producing alkaline serine protease play primary roles in protein digestion in the mesophilic FBC process.
Learning with Scope, with Application to Information Extraction and Classification (2018)

In probabilistic approaches to classification and information extraction, one typically builds a statistical model of words under the assumption that future data will exhibit the same regularities as the training data. In many data sets, however, there are scope- limited features whose predictive power is only applicable to a certain subset of the data. For example, in information extraction from web pages, word formatting may be indicative of extraction category in diffenent ways on different web pages. The difficulty with using such features is capturing and exploiting the new regularities encountered in previously unseen data. In this paper, we propose a hierarchical probabilistic model that uses both local/scope-limited features, such as word formatting, and global features, such as word content. The local regularities are modeled as an unobserved random parameter which is drawn once for each local data set. This random parameter is estimated during the inference process and then used to perform classification with both the local and global features| a procedure which is akin to automatically retuning the classifier to the local regularities on each newly encountered web page. Exact inference is intractable and we present approximations via point estimates and variational methods. Empirical results on large collections of web data demonstrate that this method significantly improves performance from traditional models of global features alone.
Purcell enhancement of the parametric down-conversion in two-dimensional nonlinear materials (2018)

Ultracompact nonlinear optical devices utilizing two-dimensional (2D) materials and nanostructures are emerging as important elements of photonic circuits. Integration of the nonlinear material into a subwavelength cavity or waveguide leads to a strong Purcell enhancement of the nonlinear processes and compensates for a small interaction volume. The generic feature of such devices which makes them especially challenging for analysis is strong dissipation of both the nonlinear polarization and highly confined modes of a subwavelength cavity. Here we solve a quantum-electrodynamic problem of the spontaneous and stimulated parametric down-conversion in a nonlinear quasi-2D waveguide or cavity. We develop a rigorous Heisenberg-Langevin approach which includes dissipation and fluctuations in the electron ensemble and in the electromagnetic field of a cavity on equal footing. Within a relatively simple model, we take into account the nonlinear coupling of the quantized cavity modes, their interaction with a dissipative reservoir and the outside world, amplification of thermal noise and zero-point fluctuations of the electromagnetic field, and other relevant effects. We derive closed-form analytic results for relevant quantities such as the spontaneous parametric signal power and the threshold for parametric instability. We find a strong reduction in the parametric instability threshold for 2D nonlinear materials in a subwavelength cavity and provide a comparison with conventional nonlinear photonic devices.
Endothelin A antagonist LU‐135252 and trandolapril in the treatment of the Cohen–Rosenthal diabetic hypertensive rat (2005)

The SBP decrease was additive when both drugs were given together. Thus, combination of ETA antagonist and ACE inhibitor appears to offer a rational fixed-dose antihypertensive therapy, which is superior to that of either drug alone. The decrease in glucose level, which was the least impressive while on LU-135252 alone, was more prominent during combination after 2 weeks, although without further decrease.
An input-process-output model of shared understanding in partially distributed conceptual design teams (2013)

In this study, we used qualitative data analysis to examine factors that are associated with shared understanding in the context of partially distributed conceptual design teams. The identified factors were then organized in an input-process-output model. The utility of the model as well as current and future works are discussed.
Glycosylation of gp116 and gp64 envelope proteins of yellow head virus of Penaeus monodon shrimp (2010)

Yellow head virus (YHV) is a highly virulent pathogen of Penaeus monodon shrimp that is classified in the genus Okavirus, family Roniviridae, in the order Nidovirales. Separation of virion proteins treated with peptide-N-glycosidase-F (PNGase-F) in SDS-polyacrylamide gels and the use of glycoprotein-specific staining methods indicated that the gp116 and gp64 envelope glycoproteins possess N-linked rather than O-linked glycans. Competitive binding inhibition of lectins with various oligosaccharide specificities indicated that glycans linked to gp64 are mannose-rich, whilst glycans linked to gp116 possess terminal N-acetylgalactosamine and N-acetylglucosamine in addition to terminal mannose-type sugars. Mass spectrometry analyses of peptides generated from YHV proteins before and after deglycosylation with PNGase-F, using combinations of the endoproteinases trypsin, Asp-N and Lys-C, confirmed occupancy of six of the seven potential N-linked glycosylation sites in gp116 and three of the four potential sites in gp64.
Help keep CMA first (2016)

Four goals lie at the heart of our strategy: (1) win additional market share and grow the CMA program substantially with an aggressive pipeline-building effort in the United States and outside, where growth has been higher; (2) drive member retention by delivering tangible value through programs, products, and services; (3) raise awareness in the student/academic market to increase membership and reach the Young CMA-Certified Professional of tomorrow; and (4) master technology that directly impacts members and our value proposition.
Building Blocks for Variational Bayesian Learning of Latent Variable Models (2007)

We introduce standardised building blocks designed to be used with variational Bayesian learning. The blocks include Gaussian variables, summation, multiplication, nonlinearity, and delay. A large variety of latent variable models can be constructed from these blocks, including nonlinear and variance models, which are lacking from most existing variational systems. The introduced blocks are designed to fit together and to yield efficient update rules. Practical implementation of various models is easy thanks to an associated software package which derives the learning formulas automatically once a specific model structure has been fixed. Variational Bayesian learning provides a cost function which is used both for updating the variables of the model and for optimising the model structure. All the computations can be carried out locally, resulting in linear computational complexity. We present experimental results on several structures, including a new hierarchical nonlinear model for variances and means. The test results demonstrate the good performance and usefulness of the introduced method.
Neonatal Tracheobronchomegaly (1987)

Tracheobronchomegaly is rarely reported in neonates. We present five cases of tracheobronchomegaly occurring in neonates receiving intensive ventilatory and oxygen support. Barotrauma is speculated to be the primary pathophysiologic factor in these cases.
Self-organizing aerial mesh networks for emergency communication (2014)

Guaranteeing network connectivity in post-disaster scenarios is challenging yet crucial to save human lives and to coordinate the operations of first responders. In this paper, we investigate the utilization of low-altitude aerial mesh networks composed by Small Unmanned Aerial Vehicles (SUAVs) in order to re-enstablish connectivity among isolated end-user (EU) devices located on the ground. Aerial ad-hoc networks provide the advantage to be deployable also on critical scenarios where terrestrial mobile devices might not operate, however their implementation is challenging from the point of view of mobility management and of coverage lifetime. In this paper, we address both these issues with three novel research contributions. First, we propose a distributed mobility algorithm, based on the virtual spring model, through which the SUAV-based mesh node-called also Repairing Units (RUs) in this study- can self-organize into a mesh structure by guaranteeing Quality of Service (QoS) over the aerial link, and connecting the maximum number of EU devices. Second, we evaluate our scheme on a realistic 3D environment with buildings, and we demonstrate the effectiveness of the aerial deployment compared to a terrestrial one, in terms of coverage and wireless link reliability. Third, we address the problem of energy lifetime, and we propose a distributed charging scheduling scheme, through which a persistent coverage of RUs can be guaranteed over the emergency scenario.
Molecular mechanical studies of proflavine and acridine orange intercalation (1981)

Previous workers have reported that proflavine and acridine orange form various structurally different complexes with the dinucleoside phosphates rCpG and dCpG, with uniform C3'-endo and mixed C3'-endo (3'-5') C2'-endo sugar puckers being observed. We present theoretical calculations, based on the method of molecular mechanics, which support the experimental observations. The results suggest that the mixed C3'-edo (3'-5') C2'-endo pucker conformation isi intrinsically more stable than the uniform C3'-endo conformation, but that the additional stabilisation gained from specific, hydrogen bonding, interactions between nucleic acid and solvent, or intramolecularly within the nucleic acid, can lead to the adoption of the latter conformation, or of variants between the two. The role played by hydrogen bonding between amino-groups and nucleic acid phosphate appears more subtle than previously supposed.