gebhart/patrepeval huggingface dataset:
Identification and characterization of a heterogeneous population of growth hormone receptors in mouse hepatic membranes. (1987)

Covalent cross-linking of radiolabeled mouse growth hormone (125I-mGH) with the homobifunctional cross-linking agent bis(sulfosuccinimidyl)suberate (BS3) to microsomal membranes prepared from late pregnant mouse liver resulted in the labeling of three specific mGH binding proteins (receptors) with apparent Mr = 125,000, 62,000, and 56,000, as measured by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions. These same three specifically labeled proteins were present, but with slightly lower apparent molecular weights, when samples were electrophoresed in the absence of reductant. Cross-linking of 125I-mGH to plasma membrane-enriched fractions of late pregnant mouse liver resulted only in the specific labeling of the two lower molecular weight receptors. Removal of all N-linked carbohydrate with peptide: N-glycosidase F resulted in decreasing the apparent molecular weights of the three receptor forms to 110,000, 50,000, and 46,000 for the 125,000, 62,000, and 56,000 molecular weight forms of the receptor, respectively. Smaller decreases in the molecular weights of all three receptor forms were also apparent after treatment with neuraminidase. However, the differences seen in the intact forms of the growth hormone receptor were also present in the deglycosylated receptors. The relationship between the three forms of the growth hormone receptor was further investigated by comparing the fragments produced by proteolytic digestion of the cross-linked receptors with Staphylococcus aureus protease and endoproteinase Lys-C. The fragments produced from all three receptor forms had very similar molecular weights, although there were slight molecular weight differences in the fragments produced by endoproteinase Lys-C digestion. The overall similarity of the fragments produced by the proteolytic digestions suggests that the three forms of the receptor are related.
DONO LA DGIRE DOCUMENTACION SOBRE LA INCORPORACION EN LA UNAM (1992)

EL 11 DE DICIEMBRE, LA DIRECCION GENERAL DE INCORPORACION Y REVALIDACION DE ESTUDIOS (DGIRE) ENTREGO SIMBOLICAMENTE AL CENTRO DE ESTUDIOS SOBRE LA UNIVERSIDAD (CESU) PARTE DE LO QUE PODRIA LLAMARSE ARCHIVO HISTORICO DE LA DGIRE, QUE REUNE ALREDEDOR DE 30 EXPEDIENTES SOBRE ACTAS CONSTITUTIVAS, LICENCIAS DE CONSTRUCCION, DOCUMENTACION ESPECIFICA SOBRE ESCUELAS INCORPORADAS Y SOBRE PLANES DE ESTUDIO, QUE SON TESTIMONIO DE UNA LABOR QUE LA MAXIMA CASA DE ESTUDIOS DESARROLLA DESDE 1928-1930.
The <i>prpR1</i> and <i>prR2 </i>arginine‐specific protease genes of <i>Porphyromonas gingivalis</i> W50 produce five biochemically distinct enzymes (1997)

The arginine‐specific protease activity of Porphyromonas gingivalis is considered to be an important factor in the pathogenic potential of this organism in destructive periodontal disease. Multiple forms of closely related Arg‐x proteases are present in the culture supernatants of P. gingivalis W50. RI is a heterodimer (α/β) in which the catalytic α chain is associated with a second β chain which functions as a haemagglutinin. RIA is a single‐chain enzyme (α) and RIB is a highly post‐translationally lipid‐modified enzyme (LPS‐α) with reduced solubility compared to the other two forms. The N‐terminal sequence of the α chain of all three forms is identical, suggesting that all these enzymes may arise by differential processing of the prpR1 (protease polyprotein for RI). In the present study we constructed a prpR1 − strain of P. gingivalis W50 by insertional gene inactivation and characterized the residual extracellular Arg‐x protease activity of the resulting mutant. Loss of prpR1 expression led to the abolition of RI, RIA and RIB but the total Arg‐x activity in the supernatant of this strain was reduced by only c . 66%. The remaining activity was composed of two novel forms of Arg‐x protease (RIIA and RIIB) which appeared to be structurally and kinetically almost identical to RIA and RIB, respectively, except for two amino acid differences in the N‐terminus at position 8 (Q→E) and position 17 (A→P) and with respect to their stability to high pH. Confirmation that RIIA and RIIB are the products of a homologous locus ( prR2 ) was obtained by cloning and sequencing the prR2 which showed the predicted substitutions in the deduced translation. These data indicate that RI, RIA and RIB are produced by prpR1 expression and a maturation pathway which can give rise to a dimer and an unmodifed‐ or LPS‐modified catalytic monomer. Furthermore, RIIA and RIIB, the products of prR2 , are exported into the culture supernatant in the absence of prpR1 expression and these forms may also contribute to the pathogenic potential of this organism in destructive disease.
Occurrence of the gasoline additive MTBE in shallow ground water in urban and agricultural areas (1995)

For additional information, contact: Director, Dakota Water Science Center, South Dakota OfficeU.S. Geological Survey1608 Mountain View Road Rapid City, SD 57702 Methyl tert-butyl ether (MTBE) is a volatile organic compound (VOC) derived from natural gas that is added to gasoline either seasonally or year round in many parts of the United States to increase the octane level and to reduce carbon monoxide and ozone levels in the air. In 1993, production of MTBE ranked second among all organic chemicals manufactured in the United States. Currently, the U.S. Environmental Protection Agency (EPA) tentatively classifies MTBE as a possible human carcinogen. Health complaints related to MTBE in the air were first reported in Fairbanks, Alaska in November 1992 when about 200 residents reported problems such as headaches, dizziness, eye irritation, burning of the nose and throat, disorientation, and nausea. Similar health complaints have been registered in Anchorage, Alaska; Missoula, Montana; Milwaukee, Wisconsin; and New Jersey.As part of the U.S. Geological Survey’s National Water-Quality Assessment (NAWQA) Program, concentrations of 60 VOCs were measured in samples from 211 shallow wells in 8 urban areas and 524 shallow wells in 20 agricultural areas. Chloroform and MTBE were the two most frequently detected VOCs. MTBE was detected in 27 percent of the urban wells and 1.3 percent of the agricultural wells. Concentrations ranged from less than the detection level of 0.2 μg/L (micrograms per liter) to as high as 23,000 μg/L. When detected, the median concentration of MTBE was 0.6 μg/L. MTBE was most frequently detected in shallow ground water in Denver, Colorado and urban areas in New England. In Denver, 79 percent of the samples from shallow urban wells had detectable concentrations of MTBE and in New England, 37 percent of the samples from urban wells had detectable concentrations. Only 3 percent of the wells sampled in urban areas had concentrations of MTBE that exceeded 20 μg/L, which is the estimated lower limit of the EPA draft drinking water health advisory level. Contaminant concentrations below the health advisory are not expected to cause any adverse effects over a lifetime of exposure. MTBE is on the EPA’s Drinking Water Priority List, which means it is a possible candidate for future regulation.
Production of tissue inhibitor of metalloproteinases 3 is selectively enhanced by calcium pentosan polysulfate in human rheumatoid synovial fibroblasts (2000)

The present study is the first to demonstrate that the new antiarthritic drug, CaPPS, selectively enhanced TIMP-3 production at the posttranscription level in cultured rheumatoid synovial fibroblasts and in the lining cells of rheumatoid synovium. By this mechanism, CaPPS may be able to modulate joint tissue destruction in rheumatoid arthritis.
Female pelvic organ prolapse: diagnostic contribution of dynamic cystoproctography and comparison with physical examination. (1999)

The correlation between finding prolapsed pelvic organs on dynamic cystoproctography and finding them on physical examination varies. Most radiographically detected rectoceles and cystoceles are found on physical examination, whereas the correlation for enteroceles and sigmoidoceles is poor. Dynamic cystoproctography provides direct visualization and quantification of female pelvic organ prolapse, information that usually can only be inferred by physical examination.
Application of Nanoparticles in Electrochemical Sensors and Biosensors (2006)

Abstract The unique chemical and physical properties of nanoparticles make them extremely suitable for designing new and improved sensing devices, especially electrochemical sensors and biosensors. Many kinds of nanoparticles, such as metal, oxide and semiconductor nanoparticles have been used for constructing electrochemical sensors and biosensors, and these nanoparticles play different roles in different sensing systems. The important functions provided by nanoparticles include the immobilization of biomolecules, the catalysis of electrochemical reactions, the enhancement of electron transfer between electrode surfaces and proteins, labeling of biomolecules and even acting as reactant. This minireview addresses recent advances in nanoparticle‐based electrochemical sensors and biosensors, and summarizes the main functions of nanoparticles in these sensor systems.
Zur Berechnung der Transzendenten von Laplace (1904)

b, ' = z a(pI1 + aa &3) Band 166.
Analog Circuit Design Automation For Performance (1992)

This paper describes an improved version of the program SEAS (a Simulated Evolution approach for Analog circuit Synthesis), in which an approach for selection of alternatives based on the evaluation of mutation values is developed, and design automafion for high performance comparators is covered.
Advances in heterocyclic natural product synthesis (1990)

Development and application of new preparative reactions in heterocyclic chemistry, Marco A. Ciufolini iodolactamization - aspects and applications, Spencer Knapp asymmetric approaches to the Yohimbine alkaloids - development of a group-selective ring-expansion process and its application to total synthesis, Jeffrey Aube and Shomir Ghosh asymmetric syntheses of alkaloids and amino acids via sulphur-containing compounds, Duy H. Hua and Jinshan Chen synthesis of heterocyclic natural products vua regio- and stereo-controlled palladium-catalyzed reactions, Pher G. Andersson and Jan E. Backvall stereochemical control of the Pictet-Spengler reaction in the synthesis of natural products, Kevin M. Czerwinski and James M. Cook.
A Semiquantitative Microassay for Measurement of Relative Number of Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (1990)

A simple semiquantitative microassay was developed for the measurement of relative number of infected peripheral blood mononuclear cells (PBMC) from individuals infected with human immunodeficiency virus (HIV). The assay is based on cocultivation of serially diluted PBMC of a seropositive person with phytohemagglutinin-stimulated normal PBMC. The microassay has comparable sensitivity with the standard virus culture method in detecting positive HIV cultures. Since the microassay uses only 2-3 x 10(5) patients' PBMC, the assay is also most suitable for HIV isolation from HIV-infected infants or from AIDS patients with extremely low T-cell counts. The microassay can also be used to measure antiviral effects of a drug on persistent HIV infection in vitro. Because the microassay measures the relative number of infected PBMC, it can be readily used for following the quantitative antiviral effect of a drug in a clinical trial.
Online, self-supervised terrain classification via discriminatively trained submodular Markov random fields (2008)

The authors present a novel approach to the task of autonomous terrain classification based on structured prediction. We consider the problem of learning a classifier that will accurately segment an image into "obstacle" and "ground" patches based on supervised input. Previous approaches to this problem have focused mostly on local appearance; typically, a classifier is trained and evaluated on a pixel-by-pixel basis, making an implicit assumption of independence in local pixel neighborhoods. We relax this assumption by modeling correlations between pixels in the submodular MRF framework. We show how both the learning and inference tasks can be simply and efficiently implemented-exact inference via an efficient max flow computation; and learning, via an averaged-subgradient method. Unlike most comparable MRF-based approaches, our method is suitable for implementation on a robot in real-time. Experimental results are shown that demonstrate a marked increase in classification accuracy over standard methods in addition to real-time performance.
Component failures based on flaw distributions (2003)

A discussion is presented of a model based on the assumption that all failures basically are due to wearout. The only real difference between long-term wearout and the failures that occur in early life and during the useful life period will be in the size of the inherent flaws or defects in the components. Large flaws connect with early life failures, small flaws connect with end-of-life-failures. The model takes several competing failure mechanisms into account. Examples and case studies are used to provide substance to the model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Surface growth in laser-focused atomic deposition (1999)

We present calculations of surface growth in laser-focused nanostructure fabrication. We show that theoretical predictions of the structure profile's shape depend sensitively on the model used to describe the growth, and also on the parameters chosen within the model. This sensitivity illustrates that growth effects can play a major role in laser-focused atomic deposition, and also suggests that this process could be utilized for studies of surface growth mechanisms.
Well-Spacing Study to Develop Stacked Tight Oil Pay in Midland Basin (2014)

Abstract Tight formations are being developed by drilling in the Midland Basin. Target intervals include Clearfork, Wolfcamp, Spraberry, Strawn, Cline, Atoka, and Mississipian formations, which are usually found between 6000 feet and 11,500 feet true vertical depth (TVD). Development is typically with vertical wells, which are stimulated with multiple hydraulic fractures targeting the expected pay intervals and are produced commingled. A significant challenge for operators is determining the optimum well locations and spacing for efficient reserve development. Operators use various field data and analytics to determine well spacing, although limited data pose challenges to making the best decisions. Numerical models can yield insights about drainage patterns and potential interference. This paper reports a case study using a geologic model, hydraulic stimulation models, and a reservoir simulation model to evaluate reduced well spacing impacts on recovered oil and economics. A three-dimensional geologic model was constructed for a 14-section area in the Midland Basin. An extensive core-log statistical study yielded calibrated rock types at the wells. Reservoir and geomechanical properties were then spatially distributed using geostatistical techniques subject to data constraints. A reservoir simulation model was then utilized on a sector area of the full model. The sector model was history-matched to early production data and historical type curves. Each well had 10–12 fracture stages, which were explicitly modeled using parameters derived from post-execution analysis of fracture job data. The paper presents history-matched simulation models that were executed to predict production and economics for 40-acre and 20-acre well spacing cases.
A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain (2007)

RNA-interference-driven loss of function in specific tissues in vivo should permit analysis of gene function in temporally and spatially defined contexts. However, delivery of efficient short hairpin RNA (shRNA) to target tissues in vivo remains problematic. Here, we demonstrate that efficiency of polyethylenimine (PEI)-delivered shRNA depends on the regulatory sequences used, both in vivo and in vitro. When tested in vivo, silencing of a luciferase target gene by shRNA produced from a hybrid construct composed of the CMV enhancer/promoter placed immediately upstream of an H1 promoter (50%) exceeds that obtained with the H1 promoter alone (20%). In contrast, in NIH 3T3 cells, the H1 promoter was more efficient than the hybrid construct (75 versus 60% inhibition of target gene expression, respectively). To test CMV-H1 shRNA efficiency against an endogenous gene in vivo, we used shRNA against thyroid hormone receptor alpha1 (TRalpha1). When vectorized in the mouse brain, the hybrid construct strongly derepressed CyclinD1-luciferase reporter gene expression, CyclinD1 being a negatively regulated thyroid hormone target gene. We conclude that promoter choice affects shRNA efficiency distinctly in different in vitro and in vivo situations and that a hybrid CMV-H1 construct is optimal for shRNA delivery in the mouse brain.
Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer (2012)

Chemoresistance is a main cause for the failure of cancer management and intensive investigation is on-going to control chemoresistant (CR) cancers. Although NF-κB has been suggested as one of the potential targets to alleviate chemoresistance of epithelial ovarian cancer (EOC), direct targeting of NF-κB may result in an unexpected effect due to the complex regulatory network via NF-κB. Here we show that AIMP2-DX2, a splicing variant of tumor suppressor AIMP2, can be a therapeutic target to control CR EOC. AIMP2-DX2 was often highly expressed in CR EOC both in vitro and in vivo. AIMP2-DX2 compromised the tumor necrosis factor alpha-dependent pro-apoptotic activity of AIMP2 via the competitive inhibition of AIMP2 binding to TRAF2 that plays a pivotal role in the regulation of NF-κB. The direct delivery of siRNA against AIMP2-DX2 into abdominal metastatic tumors of ovarian cancer using a microneedle converged on microendoscopy significantly suppressed the growth rate of tumors. The treated cancer tissues showed an enhanced apoptosis and the decreased TRAF2 level. Thus, we suggest that the downregulation of AIMP2-DX2 can be a potent adjuvant therapeutic approach for CR EOC that resulted from an aberrant activity of NF-κB.
Dynamic pricing: ecommerce - oriented price setting algorithm (2004)

Pricing in electronic commerce is based on bargaining. Pricing models that can fast change prices during transaction on the consequence of the buyer's needs is beneficial to electronic commerce. Demand sensitive model is one of the pricing models that can be used for fast changes of prices in electronic commerce. Price setting algorithm for demand sensitive model helps sellers to get decision variables, price per unit that maximizes profit for the quantity ordered by buyers. In this paper we analyze the price setting algorithms of demand sensitive model. We use a simple example to explain how the changes of price elasticity of demand changes price per unit, gross margin and quantity demanded. Also we show how the changes of quantity demanded changes the unit price and marginal cost. The investigation shows that an increase in demand ordered decreases price per unit of a good, at the same time increasing profit margin to seller and decreasing production cost. The seller extracts some of the buyer's surplus value as profits with residual surplus remaining with the buyer over and above the actual price paid. Buyers do not pay the same amount of total price for the good ordered within the same group of order, because of the difference in the net browsing cost.
PT. PUPUK SRIWIDJAJA PALEMBANG MANAGES THE HAZARDOUS AND TOXIC MATERIAL IN TERMS OF OCCUPATIONAL SAFETY AND HEALTH ASPECTS (2015)

Background : Despite its benefits to the production activities, the use of hazardous and toxic materials in any industrial activities could also pose a risk to the environment, human living and also any other living creatures. In order to avoid or at least minimize the risks of health and safety problems of the workers, it is important to manage hazardous and toxic materials well. The purpose of this research was to find out how PT. Pupuk Sriwidjaja Palembang manages the hazardous and toxic material in terms of occupational safety and health aspects. Method: This research was a descriptive study with a qualitative approach. The methods of the research are in-depth interviews, observation and documents reviews. The interviews were done to twelve informants, one of them are expert in relevant field. Result : The results of the research showed that safety and health efforts done by PT. Pusri in order to manage hazardous and toxic materials still need to be improved. It is difficult to complete the material safety data sheets that had been ordered, insufficient emergency response system in the storage room, the transportation officer also has not yet safely equipped with protection, there are still workers who work without personal protective equipment and there is still hazardous and toxic materials waste existing without symbol on its packaging. Conclusion: For a better future, workers should take material safety data sheets to the supplier at the time of acceptance hazardous and toxic materials. Besides, the quality of emergency response system in the storage room obviously needed to be improved and simulated too. Changing the no-longer adequate protective equipment for the transportation worker and improving facilities of hazardous waste management to prevent environmental contamination are the two things that also needed to be done. Keywords : hazardous and toxic materials, management, occupational safety and health
Novel on-chip variable delay transmission line with fixed characteristic impedance (2009)

On-chip electronically controllable delay elements are often used in RF designs such as phased array antenna systems. This paper presents a novel on-chip variable delay transmission line structure with fixed characteristic impedance. EM simulations show a delay change of 15.6 % is possible while the characteristic impedance of the novel transmission line varies a maximum of 3.7% from the 50 Ω target between two possible delay states.
Analysis of Self Similar Motion in the Theory of Stellar Explosion (2012)

In this paper consider a classical model of stellar explosion ,in a conducting gas of self gravitating gas propagating in a non uniform atmosphere. Similarity principle has been used to reduced the equation governing the flow to ordinary differential equation . Analytical solution of this classical model have been investigated .
Generating ASIC test vectors with Verilog (2002)

Compiling a design verification test suite is a non-trivial task. Creating that test suite to satisfy an ASIC vendor can be even more difficult. An awareness of existing Verilog HDL capabilities may assist design engineers in the creation of ASIC test vectors to satisfy ASIC-vendor vector requirements. This paper outlines simple Verilog techniques which demonstrate Verilog's power not only for describing hardware, but for creating ASIC test vectors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>