gebhart/patrepeval huggingface dataset:
DNA-binding properties and cytotoxicity of extended aromatic bisamidines in breast cancer MCF-7 cells. (2002)

The DNA binding properties of three novel extended aromatic bisamidines (1-3) possessing different dicationic terminal side chains were studied. Data from the ethidium displacement assay showed that bisamidines 1-3 have significant affinity for DNA. We studied the cytotoxic activity of bisamidines 1-3 and Hoechst 33258 in the cultured breast cancer MCF-7 cells. These data show that in broad terms the cytotoxic potency of bisamidines 1-3 in the cultured breast cancer MCF-7 cells decreases with the size of the alkyl group substituent (cyclopropyl > isopropyl > cyclopentyl), in accord with their increases in DNA affinity, as shown by the binding constant values. The bisamidines 1-3 showed comparable antitumor activity to Hoechst 33258.
Molecular markers for human colon cancer in stool and blood identified by RT-PCR. (2005)

There is a need for sensitive and specific diagnostic and prognostic molecular markers which can monitor early patterns of gene expression in non-invasive exfoliated colonocytes shed in the stool, and aggression in carcinoma cells in blood of resected colorectal cancer patients. RNA-based detection methods are more comprehensive than either DNA- or protein-based methods. By routinely and systematically being able to perform quantitative gene expression studies on non-invasive samples using carefully selected tumor-specific colon cancer genes, we can quantitatively and accurately monitor changes at various stages in the neoplastic process, allowing for surgical and/or other therapies, and thus, decrease mortality from colorectal cancer.
Base-catalysed prototropic rearrangement. Part I. Comparison of the base-catalysed and the metal carbonyl-catalysed isomerisation of allyl ethers (1972)

The light-induced isomerisation of allylic ethers in the presence of pentacarbonyliron has been compared with that brought about by a basic heterogeneous catalyst, KNH2–Al2O3. The reaction on the basic catalyst proceeds through the usual cis-mechanism. In contrast, the carbonyliron reaction gives cis- and trans-isomers, in a 1 : 1 ratio in the case of allyl phenyl ether. A π-complex was detected (by n.m.r. spectroscopy) as an intermediate in the reaction. The formation of a catalyst which was particularly active for the thermal isomerisation of olefinic double bonds was detected during the irradiation of pentacarbonyliron in allyl phenyl ether. 3-Propoxycyclohexene was readily isomerised under these conditions, whereas it remained unchanged in the presence of very strong bases. Conformational effects of the ring were observed.
A Review of Electrical Breakdown in Mixtures of SF6 and Other Gases (1979)

The outstanding electrical and arc-quenching characteristics of sulphur-hexafluoride (SF6) have already set new trends and standards for the construction of high voltage equipment. Intensive research is being carried out on the electrical properties of SF6, other electronegative gases and their mixtures with more common gases. The aims are to obtain an economical insulation with optimal electrical properties and to acquire a better understanding of their prebreakdown and breakdown behavior. Recently [1] we reviewed the breakdwon mechanisms operating in compressed gases and discussed the theoretical results in the light of experimental measurement in SF6. This paper deals with the breakdown and prebreakdown behavior of SF6 mixtures with other electron attaching and non-attaching gases. Uniform and non-uniform field breakdown under the applications of direct, alternating and impulse voltages is discussed. Improvement in properties such as higher breakdown voltages in non-uniform field gaps, less sensitivity to the electrode surface roughness and to the presence of contaminants and improved arc interruption characteristics of SF6-gas mixtures are discussed.
A A method of choice of the best alternative in the multiple solutions case in the Games Theory (2011)

In the game theory, there are a classic series of four criteria: Wald, Hurwicz, Savage, Laplace with a special importance in the choice of optimal decision in the situations of uncertainty. These criteria providing reasonable answers from different points of view. The question is to discern between different choices when the criteria do not provide a unique answer. In this paper, we present a possible way to reduce the final number of variants.
Hospital costs and outcomes among intravenous antifungal therapies for patients with invasive aspergillosis in the United States (2010)

This study determined the economic burden of aspergillosis-related hospitalisations in the United States during years when new antifungal treatments were introduced. A retrospective observational cohort study from the hospital perspective was conducted using national administrative data from the Premier Perspective™ Database. Patients (n=1603) coded for infection caused by Aspergillus species during 1835 admissions who received at least 3 days of intravenous antifungal therapy between 2000 and 2006 were included. All costs were inflated to $US 2006. Length of stay, hospital costs and mortality were compared after stratification by initial antifungal therapy. Median hospital costs were $ 52,803 (25,929-100,730) and did not differ by year over the study period. Intravenous antifungals accounted for 7.2% (range: 0.78-15.9%) of the cost of aspergillosis-related hospitalisation. Crude mortality was 36.7% and was the lowest in the last 2 years of the study (2005, 2006). Although antifungal utilisation changed over the course of the study, initial antifungal choice was not independently associated with crude mortality. In contrast, initial therapy with intravenous voriconazole was associated with reduced total hospitalisation costs and length of hospital stay. Treatment with amphotericin B lipid complex or caspofungin was also independently associated with a reduced length of hospital stay. In this large US study, mortality and costs for aspergillosis-related hospitalisations were considerable, but antifungals accounted for a small percentage of total costs associated with treatment and did not independently affect in-hospital crude mortality. Only initial treatment with intravenous voriconazole was associated with reduced total hospitalisation costs.
In-silico Prediction of Synergistic Anti-Cancer Drug Combinations Using Multi-omics Data (2019)

Chemotherapy is a routine treatment approach for early-stage cancers, but the effectiveness of such treatments is often limited by drug resistance, toxicity, and tumor heterogeneity. Combination chemotherapy, in which two or more drugs are applied simultaneously, offers one promising approach to address these concerns, since two single-target drugs may synergize with one another through interconnected biological processes. However, the identification of effective dual therapies has been particularly challenging; because the search space is large, combination success rates are low. Here, we present our method for DREAM AstraZeneca-Sanger Drug Combination Prediction Challenge to predict synergistic drug combinations. Our approach involves using biologically relevant drug and cell line features with machine learning. Our machine learning model obtained the primary metric = 0.36 and the tie-breaker metric = 0.37 in the extension round of the challenge which was ranked in top 15 out of 76 submissions. Our approach also achieves a mean primary metric of 0.39 with ten repetitions of 10-fold cross-validation. Further, we analyzed our model's predictions to better understand the molecular processes underlying synergy and discovered that key regulators of tumorigenesis such as TNFA and BRAF are often targets in synergistic interactions, while MYC is often duplicated. Through further analysis of our predictions, we were also ble to gain insight into mechanisms and potential biomarkers of synergistic drug pairs.
Optical time-division digital switching: an experiment (1983)

Tremendous research and development efforts on optical fiber transmission systems have been made throughout the world, and optical fiber transmission systems have been put into commercial service. For the next stage, an optical switching system, which can directly exchange an optical signal without electrooptical (E/O) and optoelectronic (O/E) conversion, is expected to be realized for various uses, such as an optical toll/central office, an optical PABX, and an optical toll/central office, an optical PABX, and an optical local area network. We studied optical switching systems and chose a time-division digital switching using optical fiber delay lines and optical switch matrices from today's optical device technology standpoint.
Gallium nitride devices for power electronic applications (2013)

Recent success with the fabrication of high-performance GaN-on-Si high-voltage HFETs has made this technology a contender for power electronic applications. This paper discusses the properties of GaN that make it an attractive alternative to established silicon and emerging SiC power devices. Progress in development of vertical power devices from bulk GaN is reviewed followed by analysis of the prospects for GaN-on-Si HFET structures. Challenges and innovative solutions to creating enhancement-mode power switches are reviewed.
Low-temperature solution-processed NiO<sub>x</sub>films for air-stable perovskite solar cells (2017)

A new strategy is introduced to fabricate NiO<sub>x</sub>films over perovskite layers to achieve highly stable perovskite solar cells.
Functional Recovery and Morphological Changes after Injury to the Optic Nerve (1993)

Physiological and morphological parameters of optic nerve lesions followed by functional recovery are discussed in detail. To study functional and/or morphological recovery processes, a recently developed model of the 'graded optic nerve crush' is compared with other models of lesioning. It is concluded that the optic nerve crush model is a valuable tool when studying brain repair mechanisms. First results show that functional recovery depends on the initial preservation of a sufficiently large population of ganglion cells in the retina. It takes place despite the progressive loss of retinal ganglion cells during the recovery period.
Highly Swollen Layered Nickel Oxide with a Trilayer Hydrate Structure (2007)

This paper reports the synthesis of alkali-free layered nickel oxides with a highly swollen hydrate structure, derived from NaNiO2 through soft-chemical processes involving oxidation with bromine and subsequent acid treatment. Complete removal of interlayer Na+ ions and subsequent hydration yielded a single phase of HxNiO2·nH2O (x < 1, n ∼1) with an enlarged basal spacing of 9.6 Å. The materials had a monoclinic structure (C2/m); unit cell parameters for a typical composition of H0.66NiO2·0.9H2O were a = 4.8993(8) Å, b = 2.8256(4) Å, c = 9.7598(9) Å, and β = 98.88(2)°. Rietveld refinement revealed that the structure was composed of pseudohexagonal NiO2 sheets accommodating partially occupied three layers of H2O molecules and H3O+ ions in the galleries. The highly expanded layered structure is analogous to Na0.3NiO2·1.3H2O and other layer oxides such as buserite-type manganese oxide and superconducting NaxCoO2·yH2O but differs in alkali-free composition. The 9.6 Å phase underwent partial dehydration to give a basal spacing of 7 Å upon exposure to atmosphere with a relative humidity of <30%.
De la representación objeto a la naturaleza y registro de la representación cosa, y su supuesta equivalencia. (2006)

Abordar las ideas freudianas acerca de la percepcion de los objetos y su registro, nos lleva, entre otros temas, a la supuesta equivalencia entreobjeto y cosa. Aspectos de consideracion en lo que respecta al planteamiento de la representacion conciente y la inconconciente. Por tanto, es imprescindible esclarecer en primera instancia, el origen de la representacion cosa y la tendencia a un paralelismo entre las modalidades de representacion de la cosa y el objeto.
A Nanostructured, Field Effect Transistor-Based Sensor (2007)

Abstract Central to the mechanism of detection with a sensor is the transduction of a signal associated with selective recognition of biological or chemical species of interest. Nanostructured devices, comparable in size to the biological and chemical species of interest, represent ideal transducers for enhancing signal gain and detection sensitivity. In this paper, we report on the development of a nanostructured one-dimensional field effect transistor (1D FET) device on standard silicon-on-insulator (SOI) material with enhanced sensitivity to environmental variables, such as moisture and selective ionic concentration as it relates to corrosion processes. Semiconducting channels (p-doped silicon), on the order of 50–100 nm in height and width and 2 μm in length, were fabricated using e-beam lithography with the remaining FET features fabricated using standard semiconducting processes. The one dimensional channel structure behaved as an FET device (i.e., with variation in the channel resistance upon application of a current across the source to drain electrodes for a constant applied voltage at the gate electrode).
Influence of anchor embedment angle on the strength and behaviour of FRP-to-concrete joints anchored with FRP anchors (2011)

The propensity of externally bonded fibre-reinforced polymer (FRP) composites to debond at relatively low strains severely hinders the effectiveness of FRP for the repair and strengthening of reinforced concrete (RC) structures. FRP anchors, which are also known as spike anchors, can enhance the strain capacity of the bonded FRP strengthening material. Depending on the specific strengthening constraints, anchors may be inserted into the concrete at different angles and as a result testing is required to establish the strength and behaviour of such anchored systems. This paper in turn reports the results of a series of tests on 20 single-shear FRP-to-concrete joints of which 16 joints have been anchored with FRP anchors of different embedment angles. The tests reveal that the strengths of the joints increase as the angle between the embedded anchor dowel and the surface of the concrete is increased relative to the direction of FRP plate force. Optimal anchorage arrangements enabled joint strengths of up to 160 % above unanchored control joints to be achieved. In addition, the maximum strain resisted by the FRP plate, relative to the elongation capacity of the FRP plate, was increased on average from 22 % for unanchored control joints to 67 % for optimally anchored joints.
SAMIE-LSQ: set-associative multiple-instruction entry load/store queue (2006)

The load/store queue (LSQ) is one of the most complex parts of contemporary processors. Its latency is critical for the processor performance and it is usually one of the processor hotspots. This paper presents a highly banked, set-associative, multiple-instruction entry LSQ (SAMIE-LSQ,) that achieves high performance with small energy requirements. The SAMIE-LSQ classifies the memory instructions (loads and stores) based on the address to be accessed, and groups those instructions accessing the same cache line in the same entry. Our approach relies on the fact that many in-flight memory instructions access the same cache lines. Each SAMIE-LSQ entry has space for several memory instructions accessing the same cache line. This arrangement has a number of advantages. First, it significantly reduces the address comparison activity needed for memory disambiguation since there are less addresses to be compared. It also reduces the activity in the data TLB, the cache tag and cache data arrays. This is achieved by caching the cache line location and address translation in the corresponding SAMIE-LSQ entry once the access of one of the instructions in an entry is performed, so instructions that share an entry can reuse the translation, avoid the tag check and get the data directly from the concrete cache way without checking the others. Besides, the delay of the proposed scheme is lower than that required by a conventional LSQ. We show that the SAMIE-LSQ saves 82% dynamic energy for the load/store queue, 42% for the LI data cache and 73% for the data TLB, with a negligible impact on performance (0.6%)
Clinical Uses of Benzodiazepines (1993)

HOLLISTER, LEO E. MD1; MÜLLER-OERLINGHAUSEN, BRUNO MD2; RICKELS, KARL MD3; SHADER, RICHARD I. MD4 Author Information
Decreased Bilirubin-Binding Capacity in Uremic Serum Caused by an Accumulation of Furan Dicarboxylic Acid (2000)

In chronic renal failure, substances that are effectively excreted in healthy subjects accumulate in serum. These substances, uremic toxins, include a variety of organic acids. It has been reported that a decrease in the bilirubin (BR) binding capacity occurs in the serum of renal failure patients. 3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) has a high affinity for human serum albumin (HSA) and is a potent inhibitor of the serum protein binding of many drugs. We recently reported that CMPF and BR share the binding site for dicarboxylate molecules on the HSA molecule [Pharm Res 1999;16:916-923]. In this study, in order to confirm whether CMPF is involved in the decrease of BR serum binding capacity in chronic renal failure patients, the total concentrations of uremic toxins, CMPF, and indoxyl sulfate (IS) and the free BR concentration in serum from healthy volunteers and renal failure patients were determined. Both total CMPF and IS concentrations correlate with the free BR concentration. However, results from the peroxidase method reveal that IS cannot displace BR under the physiological condition [IS]/[HSA] <1. We, therefore, conclude that CMPF is one of the substances which contribute to the decreased binding capacity of BR in uremic serum.
New Developments in Drug Dependence Studies. Mechanisms of morphine-induced rewarding effect. Involvement of NMDA receptor subunits. (2001)

The glutamate receptor contributes to excitatory synaptic transmission in the central nervous system and plays an important role in memory acquisition, learning and neurological disorders. Molecular cloning studies have revealed that NMDA receptors consist of two families, the NR1 and NR2A-NR2D subunits, and NMDA receptors are thought to be pentameric or tetrameric complexes of the NR1 subunit with one or more of the NR2 subunits. It has been proposed that NMDA receptors are implicated in the development of opioid dependence. The non-selective NMDA receptor antagonist dizocilpine has been shown to suppress not only physical but also psychological dependence produced by morphine. An intracerebroventricular (i.c.v.) treatment with a specific antibody against the carboxyl-terminal region of the NR2B subunit abolishes the morphine-induced place preference, whereas antibodies against the NR1 and NR2A subunits do not affect the rewarding effect of morphine, indicating that the blockade of the NR2B subunit suppresses the development of the morphine-induced rewarding effect. Under these conditions, the NR2B subunit protein is up-regulated in the limbic forebrain of morphine-conditioned mice. These findings suggest that the NMDA receptor, especially NR2B subunit, is an important modulator of the development and/or expression of psychological dependence on morphine.
Localización del daño ocasionado por la diabetes mellitus en el eje hipotálamo-hipofisiario-gonadal en ratas con diabetes inducida (2003)

CADA JORNADA SE VUELVE MÁS INTERESANTE\n\nLa diversidad y pluralidad continua siendo una de las características básicas de la Revista. Estamos dados a la tarea de informar a la comunidad científica y a la universitaria, sobre las investigaciones y los acontecimientos académicos más importante de nuestras carreras. La Revista de la Facultad de Farmacia incluirá próximamente mayor información sobre las actividades académicas de nuestras Escuelas, la que la convertirá en obligada fuente de consulta para los estudiosos de la Historia de la Farmacia y del Bioanálisis. Es la gran oportunidad para intentar algo distinto, para que modifiquemos lo que no está bien y fortalezcamos lo que está bien.\nAsí también, la Facultad de Farmacia y Bioanálisis celebrará en el mes de octubre sus 110 años de labores académicas contribuyendo con el desarrollo político, social, económico y cultural del país a través de sus egresados y de las diferentes instancias que conforman la institución. En el marco de múltiples actividades que se han programado para celebrar esta ocasión; la Revista de la Facultad de Farmacia se unirá a las diferentes celebraciones con el lanzamiento de la Edición Especial dedicada a tan importante evento con el fin de proyectar la mayor integración de nuestras disciplinas y una imagen de gran calidad y contenido para nuestra región y el mundo entero. Éxitos para sus organizadores.\n\n\nProf. Laura Calderón G.
Cross-Talk Between the Androgen Receptor and the Phosphatidylinositol 3-Kinase/Akt Pathway in Prostate Cancer (2007)

Prostate cancer is initially dependent on androgens for growth; hence, recurrent prostate is treated with androgen ablation which may result in progression to androgen independence characterized by a resistance to such therapy. Androgens bind to and activate the androgen receptor (AR), a member of the nuclear steroid receptor family of transcription factors, which regulates prostate cancer cell proliferation and survival in androgen-independent, as well as -dependent, tumors. Another pathway regulating proliferation and survival is the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Here we analyze reports in the literature indicating that these two pathways cooperate to regulate prostate tumor development and progression. Studies show that AR transcriptional activity and expression are regulated by Akt. In addition, androgens regulate the Akt pathway by both genomic and non-genomic effects. This explains why prostate tumors subjected to androgen ablation experience an increase in Akt phosphorylation, and suggest that the tumor compensates for the loss of one pathway with another. Different modes of interaction between the two pathways, including direct interaction, or regulation via downstream intermediates, such as the wnt/GSK-3beta/beta-catenin pathway, NF-kappaB, and the FOXO family of transcription factors, will be discussed. In addition, we will discuss the role of Akt in the interaction of the AR with upstream regulators of Akt phosphorylation, such as receptor tyrosine kinases of the EGF and IGF-1 receptor families and the tumor suppressor PTEN.
Ein neuer Weg zu SiC‐Keramik‐Vorstufen durch katalytische Synthese von präkeramischem Polymer (1990)

Durch Platin‐katalysierte Hydrosilylierung zu Siliciumcarbid‐Keramiken: Das Vinylsilan 1 reagiert zu Oligomeren des Typs 2 , die mit LiAlH 4 zu den entsprechenden Wasserstoffverbindungen reduziert werden können. Diese ergeben bei der Pyrolyse in einer Ausbeute von etwa 32% (Theorie 69%) einen keramischen SiC‐Rückstand. Bei einem Oligomer mit ausschließlich Vinyl‐Endgruppen beträgt die Ausbeute sogar 52%, was auf eine Vernetzung der Oligomere durch Reaktion zwischen Vinylgruppen und H 2 Si‐Gruppen während der Pyrolyse hinweist. magnified image