gebhart/patrepeval huggingface dataset:
Luteolin inhibits proliferation and induces apoptosis of human melanoma cells <i>in vivo</i> and <i>in vitro</i> by suppressing MMP-2 and MMP-9 through the PI3K/AKT pathway (2019)

Since the incidence rate of malignant melanoma is increasing annually, development of drugs against melanoma cell metastasis has become more urgent. Luteolin, a naturally occurring flavonoid, is abundant in our daily dietary intake and exhibits a wide spectrum of pharmacological properties. However, the potential anti-cancer role of luteolin in melanoma cells has not been fully investigated. In this study, we have explored whether luteolin inhibits the migration and invasion of A375 human melanoma cells and further elucidated the underlying anti-cancer molecular mechanism of luteolin in melanoma cells. A proliferation assay, flow cytometry and an apoptosis assay were applied to detect the effect of luteolin on the growth and apoptosis of A375 cells. Wound healing assay and transwell invasion assay were used to explore the impact of luteolin on the migration and invasion of A375 cells. Real-time quantitative PCR, western blot and immunofluorescence analysis were used to investigate the effects of luteolin on the expressions of MMP-2, MMP-9 and PI3K/AKT1 in A375 cells. A xenograft tumor animal model was used to investigate the anti-cancer effect of luteolin on the growth of the A375 cells in vivo. Our data indicated that luteolin significantly inhibited the proliferation, migration and invasion of A375 cells and induced the apoptosis of A375 cells in a concentration-dependent manner. Moreover, luteolin reduced the expressions of MMP-2 and MMP-9 and increased the expression of TIMP-1 and TIMP-2. Furthermore, luteolin significantly inhibited the tumor growth of A375 cells in a xenograft mouse model. The immunofluorescence and immunoblotting assays indicated that luteolin inhibited the phosphorylation of AKT1 and PI3K. In conclusion, both in vivo and in vitro studies showed that luteolin inhibited the proliferation and induced the apoptosis of A375 human melanoma cells by reducing the expressions of MMP-2 and MMP-9 through the PI3K/AKT pathway. Overall, luteolin can be considered as a promising anti-cancer agent for the treatment of human melanoma.
Temperature-Induced Uptake of CO<sub>2</sub> and Formation of Carbamates in Mesocaged Silica Modified with <i>n</i>-Propylamines (2010)

Adsorption-mediated CO(2) separation can reduce the cost of carbon capture and storage. The reduction in cost requires adsorbents with high capacities for CO(2) sorption and high CO(2)-over-N(2) selectivity. Amine-modified sorbents are promising candidates for carbon capture. To investigate the details of CO(2) adsorption in such materials, we studied mesocaged (cubic, Pm3n symmetry) silica adsorbents with tethered propylamines using Fourier transform infrared (FTIR) spectroscopy and volumetric uptake experiments. The degree of heterogeneity in these coatings was varied by either cosynthesizing or postsynthetically introducing the propylamine modification. In situ FTIR spectroscopy revealed the presence of both physisorbed and chemisorbed CO(2) in the materials. We present direct molecular evidence for physisorption using FTIR spectroscopy in mesoporous silica sorbents modified with propylamines. Physisorption reduced the CO(2)-over-N(2) selectivity in amine-rich sorbents. Samples with homogeneous coatings showed typical CO(2) adsorption trends and large quantities of IR-observable physisorbed CO(2). The uptake of CO(2) in mesocaged materials with heterogeneous propylamine coatings was higher at high temperatures than at low temperatures. At higher temperatures and low pressures, the postsynthetically modified materials adsorbed more CO(2) than did the extracted ones, even though the surface area after modification was clearly reduced and the coverage of primary amine groups was lower. The principal mode of CO(2) uptake in postsynthetically modified mesoporous silica was chemisorption. The chemisorbed moieties were present mainly as carbamate-ammonium ion pairs, resulting from the quantitative transformation of primary amine groups during CO(2) adsorption as established by NIR spectroscopy. The heterogeneity in the coatings promoted the formation of these ion pairs. The average propylamine-propylamine distance must be small to allow the formation of carbamate-propylammonium ion pairs.
Age-related neuroinflammatory changes negatively impact on neuronal function (2010)

Neuroinflammatory changes, characterized by an increase in microglial activation and often accompanied by upregulation of inflammatory cytokines like interleukin-1beta (IL-1beta), are common to many, if not all, neurodegenerative diseases. Similar, though less dramatic neuroinflammatory changes, are also known to occur with age. Among the consequences of these changes is an impairment in synaptic function and the evidence suggests that inflammatory cytokines may be the primary contributory factor responsible for the deficits in synaptic plasticity which have been identified in aged rodents. Specifically a decrease in the ability of aged rats to sustain long-term potentiation (LTP) in perforant path-granule cells of the hippocampus is associated with increased microglial activation. This review considers the evidence which suggests a causal relationship between these changes and the factors which contribute to the age-related microglial activation, and reflects on data which demonstrate that agents which inhibit microglial activation also improve ability of rats to sustain LTP.
Regulation of immune responses to protein therapeutics by transplacental induction of T cell tolerance (2015)

Central tolerance plays a key role in modulating immune responses to self and exogenous antigens. The absence of self-antigen expression, as in patients with genetic deficiencies, prevents the development of antigen-specific immune tolerance. Hence, a substantial number of patients develop neutralizing antibodies to the corresponding protein therapeutics after replacement treatment. In this context, the administration of missing antigens during fetal development, a key period for self-tolerance establishment, should confer early and long-lasting antigen-specific tolerance. To this end, we exploited the physiological pathway of the neonatal Fc receptor (FcRn) through which maternal immunoglobulins are transplacentally transferred to fetuses. We demonstrate that Fc-fused antigens administered to pregnant mice reach fetal lymphoid organs in an FcRn-dependent manner, accumulate in antigen-presenting cells of myeloid origin, and promote the generation of both thymic and peripheral antigen-specific regulatory T cells. This strategy was successfully pursued in a mouse model of hemophilia A, where maternofetal transfer of the Fc-fused immunodominant domains of coagulation factor VIII conferred antigen-specific tolerance. Transplacental tolerance induction with Fc-fused proteins may thus prove valuable to prevent alloimmunization after replacement protein therapy for congenital deficiencies.
Desarrollar sin escribir código: Desarrollo de aplicaciones (1995)

Clarion para Windows es una herramienta que genera buena parte del codigo necesario para la construccion de nuestras aplicaciones.
Electron-Hole Pair Relaxation Dynamics in Binary Copper-Based Semiconductor Quantum Dots (2005)

The relaxation dynamics of the charge carriers in copper-based semiconductor quantum dots were investigated using femtosecond time-resolved pump-probe spectroscopy. It was found that copper oxide quantum dots show significantly longer carrier lifetimes ( and a nanosecond component) compared to the copper sulfides . This is probably due to a more perfect surface structure and less trapping in the copper oxide system. Both quantum dot materials seem to be interesting for solar cell applications based on the presented study.
The use of<i>ACORN</i>in solving a 39.5 kDa macromolecule with 1.9 Å resolution laboratory source data (2004)

Data from the alkaline cellulase apo form were collected at a resolution of 1.9 A using an in-house X-ray source (Cu K alpha). By using different fragments of helices from the model solved by macromolecular crystallographic means, the direct-methods program ACORN was used to arrive at the complete model. Attempts have been made to use various percentages of input phasing information from these helices. The minimum input phasing required in feeding the fragments was about 14% of the whole structure. The phases obtained from ACORN were of superb quality, allowing automated model building to be carried out using ARP/wARP. Minimal manual model building was required and the structure determination was completed using the maximum-likelihood refinement program REFMAC. The whole process, starting from the running of ACORN and ending with the refined model, took nearly 15 h of CPU time using a Pentium III PC.
Transverse relaxation-optimized NMR spectroscopy with the outer membrane protein OmpX in dihexanoyl phosphatidylcholine micelles (2001)

The (2)H,(13)C,(15)N-labeled, 148-residue integral membrane protein OmpX from Escherichia coli was reconstituted with dihexanoyl phosphatidylcholine (DHPC) in mixed micelles of molecular mass of about 60 kDa. Transverse relaxation-optimized spectroscopy (TROSY)-type triple resonance NMR experiments and TROSY-type nuclear Overhauser enhancement spectra were recorded in 2 mM aqueous solutions of these mixed micelles at pH 6.8 and 30 degrees C. Complete sequence-specific NMR assignments for the polypeptide backbone thus have been obtained. The (13)C chemical shifts and the nuclear Overhauser effect data then resulted in the identification of the regular secondary structure elements of OmpX/DHPC in solution and in the collection of an input of conformational constraints for the computation of the global fold of the protein. The same type of polypeptide backbone fold is observed in the presently determined solution structure and the previously reported crystal structure of OmpX determined in the presence of the detergent n-octyltetraoxyethylene. Further structure refinement will have to rely on the additional resonance assignment of partially or fully protonated amino acid side chains, but the present data already demonstrate that relaxation-optimized NMR techniques open novel avenues for studies of structure and function of integral membrane proteins.
Validation and test generation for oscillatory noise in VLSI interconnects (1999)

Inductance of on-chip interconnects gives rise to signal overshoots and undershoots that can cause logic errors. By considering technology trends, we show that in 0.13 /spl mu/m technology such noise in local interconnects embedded in combinational logic can exceed the threshold voltage. We show the impact of such noise on different kinds of circuits. The magnitude of this noise can increase due to process variations. We present an algorithm for generating vectors for validation and manufacturing test to detect logic-value errors caused by inductance induced oscillation. To facilitate the vector generation method, we have derived analytical expressions, as functions of rise and fall times for (i) the magnitude of overshoots and undershoots, and (ii) the settling time, i.e., the time required for the circuit response to settle to a bound close to the final value.
El desarrollo científico - técnico al servicio del proceso de adaptación del niño /a preescolar (2016)

El presente articulo tiene como finalidad ofrecer a los docentes y estudiantes en formacion como profesionales en la carrera Educacion Preescolar del ISP, un material que ha sido elaborado a partir del analisis de diferentes fuentes teoricas y documentales acerca del proceso de adaptacion de los ninos /as a las instituciones infantiles basado en el desarrollo de la ciencia y la tecnica; el mismo se ha concebido debido a la no existencia en la institucion de literatura donde aparezca de manera compilada la informacion.
GOODNESS‐OF‐FIT AND DISCORDANCY TESTS FOR SAMPLES FROM THE WATSON DISTRIBUTION ON THE SPHERE (1986)

Summary The only parametric model in current use for axial data from a rotationally symmetric bipolar or girdle distribution on the sphere is the Watson distribution. This paper develops methods for evaluating the model as a fit to data using graphical and formal goodness‐of‐fit tests, and tests of discordancy.
Highly Reliable Ohmic Contacts to N-Polar n-Type GaN for High-Power Vertical Light-Emitting Diodes (2011)

We report on the formation of highly reliable Ti/Al-based Ohmic contacts to N-polar n-GaN for vertical light-emitting diodes via laser-annealing. All as-deposited samples are Ohmic with specific contact resistances of 1.1 - 4.3 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> Ω cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . After annealing at 250°C, unlike the untreated sample, the laser-annealed samples remain Ohmic with specific contact resistances of 2.6- 3.9 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> Ω cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The laser-annealed samples remain electrically stable up to 60 min at 300°C. Laser-annealing causes the formation of interfacial TiN/β -AlN phases with rock salt structure. Based on X-ray photoemission spectroscopy and scanning transmission electron microscopy results, possible Ohmic mechanisms are described.
A 60&#x2013;90 MHz cochlear-based channelizer (2011)

This paper presents a 7-channel channelizer based on the mammalian cochlea. The cochlea is an amazing channelizing filter, covering three decades of bandwidth with over 3,000 channels in a very small physical space. Using a simplified mechanical cochlear model and its electrical analogue, a design method is demonstrated for RF and microwave channelizers that retains the desirable features of the cochlea including the ability to cascade a large number of channels (for multiple-octave frequency coverage), and a high-order stop-band rejection. The channelizer is successfully demonstrated using both the top-C coupled and tubular filter topologies. Application areas include wide band, contiguous-channel receivers for signal intelligence or spectral analysis.
A general compiler framework for speculative multithreaded processors (2004)

Speculative multithreading (SpMT) promises to be an effective mechanism for parallelizing nonnumeric programs, which tend to have irregular and pointer-intensive data structures and complex flows of control. Proper thread formation is crucial for obtaining good speedup in an SpMT system. This paper presents a compiler framework for partitioning a sequential program into multiple threads for parallel execution in an SpMT system. This framework is very general and supports speculative threads, nonspeculative threads, loop-centric threads, and out-of-order thread spawning. It is therefore useful for compiling for a wide variety of SpMT architectures. For effective partitioning of programs, the compiler uses profiling, interprocedural pointer analysis, data dependence information, and control dependence information. The compiler is implemented on the SUIF-MachSUIF platform. A simulation-based evaluation of the generated threads shows that the use of nonspeculative threads and nonloop speculative threads provides a significant increase in speedup for nonnumeric programs.
The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages (2000)

Our objective was to investigate sympathetic and sensory nerve fibers in synovial tissue in rheumatoid arthritis (RA) and osteoarthritis (OA) in relation to histological inflammation and synovial cytokine and norepinephrine (NE) secretion. Immunohistochemistry was used to detect nerve fibers and inflammatory parameters. A superfusion technique of synovial tissue pieces was used to investigate cytokine and NE secretion. In RA, we detected 0.2 +/- 0.04 tyrosine hydroxylase-positive (TH-positive=sympathetic) nerve fibers/mm2 as compared to 4.4 +/- 0. 8 nerve fibers/mm2 in OA (P<0.001). In RA, there was a negative correlation between the number of TH-positive nerve fibers and inflammation index (RRank=-0.705, P=0.002) and synovial IL-6 secretion (RRank=-0.630, P=0.009), which was not found in OA. Substance P-positive (=sensory) nerve fibers were increased in RA as compared to OA (3.5+/-0.2 vs. 2.3+/-0.3/mm2, P=0.009). Despite lower numbers of sympathetic nerve fibers in RA than in OA, NE release was similar at baseline (RA vs. OA: 152+/-36 vs. 106+/-21 pg/ml, n.s.). Basal synovial NE secretions correlate with the number of TH-positive CD 163+ synovial macrophages (RA: RRank=0.622, P=0.031; OA: RRank=0.299, n.s.), and synovial macrophages have been shown to produce NE in vitro. Whereas sympathetic innervation is reduced, sensory innervation is increased in the synovium from patients with longstanding RA when compared to the synovium from OA patients. The differential patterns of innervation are dependent on the severity of the inflammation. However, NE secretion from the synovial tissue is maintained by synovial macrophages. This demonstrates a loss of the influence of the sympathetic nervous system on the inflammation, accompanied by an up-regulation of the sensory inputs into the joint, which may contribute to the maintenance of the disease.
Novel coronavirus 2019 (COVID-19) (2020)

With a rapidly growing death rate and more than 200,000 confirmed cases worldwide, COVID-19 has become a global pandemic and major hit to our healthcare systems. While several companies have already begun vaccine trials and healthcare facilities have been using a wide-range of medications to treat the virus and symptoms, there is not yet an approved medication regimen for COVID-19 infections. The alarming increase in cases per day adds additional pressure to find a cure and decrease the global health burden and mortality rate.
Analytical approach to the optimal linear matrix with comprehensive error metric (2004)

In digital color imaging, the color information of objects should be reproduced as accurate as possible (unless preferred color reproduction is demanded), on the other side, the intrinsic imaging noise will propagate to the captured image and affect the final image quality. Previous studies have not shown how the color accuracy or noise reduction should be emphasized. Both the noise performance and color accuracy performance should be balanced in order to achieve better total perceived image quality. In this paper, a new comprehensive error metric that is a flexible trade-off between color accuracy and RMS noise is proposed. The linear matrix that converts the device signals to device independent color signals is analytically optimized by minimizing this comprehensive error metric. By changing the weights to the color and noise components, one can expect a reproduced image that achieves better color accuracy yet more noise, or an image that has worse color accurate but less noise, depending on applications and capture conditions. The analytical approach presents a full perspective of the color and noise characteristics in digital color imaging devices.
CO/sub 2//H/sub 2/O gas sensor with a Fabry-Perot filter (2003)

An electrostatically driven tunable MEMS Fabry-Perot filter with wide wavelength range from 2.5 /spl mu/m to 4.5 /spl mu/m has been developed for NDIR CO/sub 2//H/sub 2/O gas sensors. The Fabry-Perot filter is equipped with the NDIR system, and the principle of this gas sensing method has been confirmed.
Flight Object Sharing Capability Using Blockchain (2020)

This paper describes a concept and a prototype for sharing flight information using blockchain technology. Providing all stakeholders access to complete, consistent, and up-to-date information about each flight facilitates efficient aviation operations. Existing flight information exchange methods are limited; the concept of a “flight object” that provides a complete solution for all stakeholders has yet to be realized. A complete solution requires either a centrally administered data store, which is unsuitable for an international context, or a distributed ledger. Distributed ledgers are at the heart of blockchain technology, which makes this technology a good match for implementing the flight object. The authors have proven it is possible to provide a complete flight object solution using blockchain technology by demonstrating a prototype based on Tendermint: an open-source blockchain implementation. The demonstrated solution offers additional benefits like strong integrity guarantees and role-based update permissions enforcement. Prototype performance indicates a production implementation is likely to provide sufficient speed and capacity to support global aviation operations for flight planning negotiation, as well as possible future concepts such as trajectory-based operations and international flow management. The paper’s conclusion discusses steps necessary for the flight object sharing capability to be adopted as the basis for a real-world international aviation solution.
Simulation of 3D Mesoscale Structure Formation in Concentrated Aqueous Solution of the Triblock Polymer Surfactants (Ethylene Oxide)<sub>13</sub>(Propylene Oxide)<sub>30</sub>(Ethylene Oxide)<sub>13</sub> and (Propylene Oxide)<sub>19</sub>(Ethylene Oxide)<sub>33</sub>(Propylene Oxide)<sub>19</sub>. Application of Dynamic Mean-Field Density Functional Theory (1999)

We simulate the microphase separation dynamics of aqueous solutions of the triblock polymer surfactants (ethylene oxide)13(propylene oxide)30(ethylene oxide)13 and (propylene oxide)19(ethylene oxide)33(propylene oxide)19 by a dynamic variant of mean-field density functional theory for Gaussian chains. This is the first 3D mesoscale model for the dynamic behavior of specific complex polymer solutions. Different mesoscale structures (micellar, hexagonal, bicontinuous, and lamellar and dispersed coexisting phases) are formed depending on composition. The numerical results are in good agreement with experiment. The intermediate hexagonal and bicontinuous phases of (ethylene oxide)13(propylene oxide)30(ethylene oxide)13 solution retain a rich defect structure. Concentrated solution (60%) of (propylene oxide)19(ethylene oxide)33(propylene oxide)19 shows the onset of macrophase separation, with small water droplets dispersed throughout the system. We confirm the experimental observation that the lamellar phase formation does not depend on the block sequence. Quenched from homogeneous state, the kinetics of each system consists of a fast local aggregation stage and subsequent slow rearrangement by defect annihilation. We conclude that the simulation method is a valuable tool for description of 3D morphology formation in a wide variety of complex polymer liquids.
Truly Innovative 28nm FDSOI Technology for Automotive Micro-Controller Applications embedding 16MB Phase Change Memory (2018)

For the first time we propose a 28nm FDSOI e-NVM solution for automotive micro-controller applications using a Phase Change Memory (PCM) based on chalcogenide ternary material. A complete array organization is described exploiting body biasing capability of Fully Depleted Silicon On Insulator (FDSOI) transistors. Leveraging triple gate oxide integration with high-k metal gate (HKMG) stack, a true 5V transistor with high analog performance has been demonstrated. Reliable PCM 0,036um <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> analytical cell with 2 decades programming window after 1 Million of cycles has been demonstrated. Finally, current distributions based on a fully integrated 16MB macro-cell is presented achieving Bit Error Rate (BER) <; 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-8</sup> after multiple bakes at 150°C and 10k cycling of code storage memory.