gebhart/patrepeval huggingface dataset:
Cloud software upgrades: Challenges and opportunities (2011)

The fast evolution pace for cloud computing software is on a collision course with our growing reliance on cloud computing. On one hand, cloud software must have the agility to evolve rapidly, in order to remain competitive; on the other hand, more and more critical services become dependent on the cloud and demand high availability through firm Service Level Agreements (SLAs) for cloud infrastructures. This race between the needs to increase both the cloud upgrade frequency and the service availability is unsustainable. In this paper we highlight challenges and opportunities for upgrades in the cloud. We survey the release histories of several cloud applications to analyze their evolution pace, and we discuss the shortcomings with current cloud upgrade mechanisms. We outline several solutions for sustaining this evolution while improving availability, by focusing on the novel characteristics of cloud computing. By discussing several promising directions for realizing this vision, we propose a research agenda for the future of software upgrades in the cloud.
Mobile Bluetooth networking: technical considerations and applications (2003)

A growing number of mobile devices in the marketplace now have Bluetooth functionality; allowing wireless communication between enabled devices. Presently, the application for Bluetooth is to replace wired connections to existing peripherals such as hands-free headsets and digital cameras. With the number of Bluetooth enabled mobile handsets growing, the possibility of using these wireless links to form ad-hoc networks becomes apparent. This combined with the relatively recent ability for third party developers to access Bluetooth functions on modern Smartphones presents us with a new technology with which to develop applications. This paper aims to investigate the technical considerations involved with networking groups of mobile users via Bluetooth with their mobile devices. Range, security and operational limitations are all considered. Also discussed are the enabling technologies, such as the JSR-82 Bluetooth API for Java and the Symbian based Series 60 Smartphone operating system. Finally, possible applications and their technical implications are discussed, including gaming, IM and file sharing. The impact of such technology on existing mobile networks is examined.
ReMoteCare: Health Monitoring with Streaming Video (2008)

Governments the world over are worried about the increasing costs of providing healthcare to elderly and infirm persons whose numbers are growing rapidly. This paper describes ReMoteCare, a prototype we have developed for remote healthcare monitoring using a Wireless Sensor Network (WSN) Pulse Oximeters, environmental sensors and streaming video to monitor patients. To illustrate the functionality of the prototype we describe three typical remote health monitoring scenarios set in an aged care facility. Finally a series of experimental scenarios were developed and implemented in a laboratory setting to evaluate the reactivity of the monitoring system to a series of physiological conditions that cause the streaming video to alert the observer to potential problems.
Fraktionierung mehrfach ungesättigter Fettsäuren aus verschiedenen natürlichen Rohstoffen (1986)

Abstract Die Samenöle der schwarzen Johannisbeere, des Borretschs und der Nachtkerze sind bekannte Rohstoffe für γ‐Linolensäure (GLA) mit Konzentrationen bis zu 25% für Borretschöl. Derartige GLA‐Gehalte sind für die meisten Anwendungen dieser Öle ausreichend. In speziellen Fällen werden höhere Konzentrationen bis zu 70% GLA oder mehr benötigt. GLA läßt sich aus diesen Rohstoffen weder durch Destillation noch durch fraktionierte Kristallisation anreichern. Die Trennung von Fettsäuren mittels präparativer Hochleistungs‐Flüssigkeits‐Chromatographie gelingt nur auf Reversed‐Phase‐Kolonnen des RP‐18‐Typs. Eine spezifische Anreicherung von γ‐Linolensäure ist jedoch durch Fraktionierung von Fettsäuren mit Harnstoff möglich, auch von Fettsäuren des schwarzen Johannisbeerkernöls, das neben 15‐20% GLA noch bis zu 14% α‐Linolensäure enthält. Bei Anwendung dieses Verfahrens in einer Pilot‐Anlage konnte, ausgehend von schwarzem Johannisbeerkernöl, ein 70 bis 80% iges γ‐Linolensäurekonzentrat erhalten werden, wobei je nach Größe der Anlage auch eine 2‐Stufen‐Fraktionierung vorzusehen ist.
Efficient computation of minimal polynomials in algebraic extensions of finite fields (1999)

Article Efficient computation of minimal polynomials in algebraic extensions of finite fields Share on Author: Victor Shoup IBM Zurich Research Lab, Säumerstr. 4, 8803 Rüschlikon, Switzerland IBM Zurich Research Lab, Säumerstr. 4, 8803 Rüschlikon, SwitzerlandView Profile Authors Info & Claims ISSAC '99: Proceedings of the 1999 international symposium on Symbolic and algebraic computationJuly 1999 Pages 53–58https://doi.org/10.1145/309831.309859Published:01 July 1999 27citation365DownloadsMetricsTotal Citations27Total Downloads365Last 12 Months7Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A novel approach to stabilization of protein drugs in poly(lactic-co-glycolic acid) microspheres using agarose hydrogel (1998)

A novel approach has been taken to stabilize protein drugs in poly(lactic-co-glycolic acid) (PLGA) microspheres. This approach creates a new protein drug delivery system, which is based on the combination of agarose hydrogel particles and PLGA microspheres. This combination produces a heterogeneously structured polymeric composite. The protein drug molecules are encapsulated in the agarose hydrogel particles and the drug-containing agarose hydrogel particles are further dispersed in the PLGA microspheres. One PLGA microsphere may contain many agarose hydrogel particles to form a PLGA–agarose composite microsphere. The PLGA–agarose composite microspheres have spherical shape and a smooth surface. They possess a normal or Gaussian size distribution and an average diameter of 150 μm. The PLGA–agarose composite microspheres have higher protein loading efficiency than that of the conventional PLGA microspheres. The hydration of the PLGA–agarose composite microsphere matrix is faster than that of the conventional PLGA microspheres. Protein drugs can be slowly released from the PLGA–agarose composite microspheres. The agarose hydrogel particles can stabilize protein drugs in the PLGA matrix, which is the major advantage of this novel protein drug delivery system over the conventional PLGA microspheres.
Hepatic malignancies: improved treatment with intraarterial Y-90. (1988)

An improved treatment method for hepatic malignancies with yttrium-90 incorporated into the matrix of glass microspheres was evaluated prospectively. Fifteen patients with 12 metastatic colorectal cancers, one carcinoid, one islet cell tumor, and one hepatoma were treated with three dose levels: 5,000 cGy (5,000 rad), ten patients; 7,500 cGy (7,500 rad), three patients; and 10,000 cGy (10,000 rad), two patients. Mean follow-up was 7 months (range, 2-12 months). Stable disease in the liver was seen in ten patients, four of whom had concurrent progression of extrahepatic disease, which resulted in two deaths. Two additional deaths were not directly related to the malignant process. Progression of liver disease was found in five patients, with three deaths occurring at 7-8 months. No procedural, hematologic, or pulmonary complications occurred. Late gastroduodenal ulceration occurred at 6-8 weeks in three patients who had histories of chronic alcohol abuse. This method of therapy seems to be feasible and efficient. Caution is necessary with high doses or with patients with a history of or predisposition to gastroduodenal ulcers.
Nicotinic Acetylcholine Receptors Interact with Dopamine in Induction of Striatal Long-Term Depression (2002)

The dorsal striatum participates in motor function and stimulus-response or "habit" learning. Acetylcholine (ACh) is a prominent neurotransmitter in the striatum and exerts part of its actions through nicotinic cholinergic receptors. Activation of these receptors has been associated with the enhancement of learning and certainly is instrumental in habitual use of nicotine. Nicotinic receptors have also been suggested to be a possible therapeutic target for disorders of the basal ganglia. In this report we show that the activation of nicotinic acetylcholine receptors in the dorsal striatum contributes to dopamine (DA)- and activity-dependent changes in synaptic efficacy. High-frequency activation of glutamatergic synapses onto striatal neurons results in a long-term depression (LTD) of synaptic efficacy that is dependent on the activation of dopamine receptors. This stimulation also produces robust increases in extracellular dopamine concentration as well as strong activation of cholinergic striatal interneurons. Antagonists of nicotinic acetylcholine receptors inhibit striatal LTD. However, on coapplication of dopamine reuptake inhibitors with nicotinic receptor antagonists, activity-induced striatal LTD is restored. Dopamine release is modulated by activation of nicotinic receptors in the dorsal striatum, and activation of nicotinic receptors during high-frequency synaptic activation appears to be capable of interacting with dopaminergic actions that lead to striatal LTD. Our results suggest that stimulation of mechanisms involved in striatal synaptic plasticity is an important role for striatal nicotinic acetylcholine receptors and that these mechanisms may contribute to the enhancement of learning and habit formation produced by nicotine intake.
[Isolation, identification and field control efficacy of an endophytic strain against tobacco bacterial wilt (Ralstonia solanacarum)]. (2007)

In this paper, an endophytic strain B-001 against tobacco bacterial wilt (Ralstonia solanacarum) was isolated from the stem of healthy tobacco in R. solanacarum-infected fields, which had a stronger inhibitory effect on some kinds of gram-positive bacteria, gram-negative bacteria, and pathogenic fungi. This strain belonged to Bacillus, and its 16S rDNA after PCR and sequencing had an accession of GenBank being DQ444283. The 16S rDNA phylogenetic tree was constructed with MEGA3, and compared with the published 16S rDNA sequences of relative bacteria species. B-001 had a 99.2% sequence similarity with Bacillus subtilis (DQ415893). According to the morphological, physiological and biochemical characteristics, and based on phylogenetic analysis, B-001 was identified as a strain of B. subtilis. Field experiments in Guiyang and Ningxiang counties of Hunan Province showed that in 2005 and 2006, the control efficacy of B-001 on R. solanacarum ranged from 40.03% to 78. 14%, better than that of Streptomycini.
Structure-less content-based routing in mobile ad hoc networks (2005)

The decoupling and asynchrony properties of the content-based publish-subscribe paradigm makes it very appealing for dynamic wireless networks, like those that often occur in pervasive computing scenarios. Unfortunately, none of the currently available content-based publish-subscribe middleware fit the requirements of such extreme scenarios in which the network is subject to very frequent topological reconfigurations due to the mobility of nodes. In this paper we propose a protocol for content-based message dissemination tailored to mobile ad hoc networks (MANETs) with frequent topological changes. Message routing occurs without the support of any network-wide dispatching infrastructure thus eliminating the issue of maintaining such logical topology on top of a time varying physical topology. The paper reports an extensive simulation study, which provides numerical evidence of the effectiveness of the approach.
Paper Mill Effluent Decolorization by Fifty <i>Streptomyces</i> Strains (1994)

Fifty actinomycete strains isolated from lignocellulosic substrates were examined for the ability to remove the color from a paper mill effluent obtained after semichemical alkaline pulping of wheat straw. Streptomyces sp. strains UAH 15, UAH 23, UAH 30, and UAH 51 were selected for their ability to decolorize the effluent in a liquid medium containing 1% (wt/vol) glycerol, 0.2% (wt/vol) ammonium sulfate, and 80% (vol/vol) effluent. The highest levels of decolorization achieved after the strains grew were 60 to 65%. Strains UAH 30 and UAH 51 were selected for further study because of their different patterns of effluent decolorization during growth. Fractionation of the decolorized effluent by gel permeation chromatography demonstrated that there were reductions in the levels of absorbance of the high- and medium-molecular-weight compounds. These fractions were mainly responsible for the color of the effluent, while the last fractions, the low-molecular-weight compounds, could have been responsible for the residual color of the decolorized effluent. Thin-layer chromatography revealed significant differences among the patterns of bands corresponding to the acidified supernatants obtained after precipitation of alkali-lignin from the effluent samples decolorized by different Streptomyces strains.
Inhibition of antibodies to CD3 surface antigen and phytohemagglutinin-mediated T cellular responses by inhibiting Ca2+/phospholipid-dependent protein kinase activity with the aid of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride. (1987)

Ca2+/phospholipid-dependent kinase activity (C-kinase) plays an important second messenger role in T lymphocyte responses initiated by the cluster of differentiation (CD3) complex and presumably also lectinic receptors. During treatment with submitogenic or mitogenic amounts of phytohemagglutinin, as well as with anti-CD3 monoclonal antibody and 12-O-tetradecanoyl 13-phorbol acetate, the enzyme was intracellularly redistributed between the cytosol and the surface membrane. Submitogenic amounts of lectin and anti-CD3 were ineffective in inducing proliferation unless exogenous interleukin 2 (IL-2) was supplied, implying that even though IL-2 receptors were expressed, additional signals were required for IL-2 production. This would also indicate that there is a direct relationship between activation of C-kinase and expression of IL-2 receptors. The importance of C-kinase was further substantiated by the ability of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride (H7), a potent inhibitor of this enzyme, to interfere with IL-2 receptor expression and cellular [methyl-3H]thymidine uptake during primary activation. The drug concentration at which these cellular responses were inhibited by 50% was about the same as that which decreased c-kinase activity by 50% in vitro. H7 also prevented anti-CD3-induced translocation in intact cells. This effect may be related to competition with the phosphatidylserine binding site, which is important for membrane attachment. This drug apparently also interferes with the active center of the enzyme as demonstrated by its ability to inhibit Ca2+/phospholipid-independent phosphorylation of protamine sulfate. This additional mode of inhibition may be important in suppressing intact cell responses under circumstances during which the enzyme displacement to the membrane is nonphysiologic in nature, e.g., during treatment with 12-O-tetradecanoyl 13-phorbol acetate.
INCREASING EFFICIENCY OF PERITONEAL DIALYSIS (1965)

Intermittent peritoneal dialysis is a safe procedure which does not demand the continuous presence of a highly trained dialysis team(1, 2). However, as usually performed, it is relatively inefficient, and therefore requires a prolonged dialysis time and large volumes of sterile solution to achieve the desired result. Previous attempts have been made to improve efficiency by increasing dialysate exchange rate(2) and by continuously flowing fresh dialysis solution through the peritoneal cavity(3,4). With both methods, clearance was enhanced by increasing flow rate up to 60 ml. /min. At higher dialysate flows, clearance diminished. Recirculation peritoneal dialysis is anew method to increase efficiency of peritoneal dialysis without using large volumes of sterile dialysate. With this technique a reservoir of sterile intraperitoneal fluid is continuously recirculated through an extracorporeal dialyzer and back into the peritoneal cavity at a rapid flow rate. Recirculation peritoneal dialysis is safe and easy to perform. Furthermore, clearance rates obtained in the present study were far in excess of those achieved with other methods of peritoneal dialysis.
Removal of Gaseous Alkali Metal Compounds from Hot Flue Gas by Particulate Sorbents (1980)

Six commercially available materials have been tested as granular sorbents to be used in granular-bed filters for the removal of gaseous alkali metal compounds from the hot (1073 to 1153 K) flue gas of pressurized fluidized-bed combustors (PFBC) for proposed combined-cycle power generation. Tests were performed using a simulated dry flue gas of PFBC in a laboratory-scale, fixed-bed combustor. Diatomaceous earth and activated bauxite were found to be the two most promising sorbents. The experimental results of screening tests are presented, along with the effects of temperature and superficial velocity and space velocity of the flue gas on the sorption performance for the two sorbents. Possible sorption mechanisms, applications of the sorbents and preliminary cost evaluations are discussed.
Visibility learning in large-scale urban environment (2011)

A crucial step in many vision based applications, such as localization and structure from motion, is the data association between a large map of known 3D points and 2D features perceived by a new camera. In this paper, we propose a novel approach to predict the visibility of known 3D points with respect to a query camera in large-scale environments. In our approach, we model the visibility of each 3D point with respect to a camera pose using a memory-based learning algorithm, in which a distance metric between cameras is learned in an entirely non-parametric way. We show that by fully exploiting the geometric relationships between the 3D map and the camera poses, as well as the related appearance information, the resulting prediction is much more robust and efficient than conventional approaches. We demonstrate the performance of our algorithm on a large urban 3D model in terms of both speed and accuracy.
Human antiidiotypic antibody against opiate receptors (1988)

Sera containing antibodies to beta-endorphin from 2 patients with major depressive disorder were shown to have antidiotypic antibodies that specifically inhibited reactivity between anti-beta-endorphin IgG and beta-endorphin. Autologous and homologous antiidiotypic anti-anti-beta-endorphin IgG antibodies were isolated by affinity chromatography. The purified antiidiotypic antibody did not bind beta-endorphin but competed with [125I]beta-endorphin for rat brain opiate receptors. Normal IgG that was similarly treated had negligible competitive effects. The antibody bound to the membrane preparation; such binding was inhibited by opiate receptor ligands. Binding of the antiidiotype to a 60,000-dalton protein from rat brain was detected by Western immunoblot analysis. This protein corresponds in molecular weight to proteins proposed to be components of opiate receptors. These findings imply that immune reactivity to neuropeptides could contribute to psychiatric impairment.
Fluorometric Determination of δ-Aminolaevulinate Dehydratase Activity in Human Erythrocytes as an Index to Lead Exposure (1975)

We describe a fluorometric method for determining delta-aminolaevulinate dehydratase (EC 4.2.1.24) activity in human erythrocytes and compare it with the existing colorimetric method. Incubation conditions are identical. In the proposed method, the porphobilinogen formed during incubation is converted to a stable and highly fluorescent uroporphyrin by heating for 20 min at 93 degrees C in an acidic medium in the presence of air. The correlation between results by the two methods was good (r = 0.89). We found a good negative correlation between the activity of the enzyme and the concentration of circulating lead with both methods (r = -0.61 for present method and -0.59 for colorimetric method) for groups of persons subjected to various degrees of lead exposure. Our method is more sensitive and accurate, requires less sample, and the fluorescence is more stable than is the color in the colorimetric method.
Design of tunable optical cavity based on near-field optical coupling between subwavelength periodic nanostructures (2004)

The design of a tunable resonant cavity optical filter based on variable near-field coupling between nanostructured gratings is presented. The study shows that as the functionality of the device depends primarily on lateral rather than longitudinal movement of the nanostructured gratings with respect to each other, an optical filter based on this approach could benefit from implementation using MEMS technology.
The <i>MSP1</i> Gene Is Necessary to Restrict the Number of Cells Entering into Male and Female Sporogenesis and to Initiate Anther Wall Formation in Rice (2003)

The function of the novel gene MSP1 (MULTIPLE SPOROCYTE), which controls early sporogenic development, was elucidated by characterizing a retrotransposon-tagged mutation of rice. The MSP1 gene encoded a Leu-rich repeat receptor-like protein kinase. The msp1 mutation gave rise to an excessive number of both male and female sporocytes. In addition, the formation of anther wall layers was disordered and the tapetum layer was lost completely. Although the mutation never affected homologous chromosome pairing and chiasma maintenance, the development of pollen mother cells was arrested at various stages of meiotic prophase I, which resulted in complete male sterility. Meanwhile, plural megaspore mother cells in a mutant ovule generated several megaspores, underwent gametogenesis, and produced germinable seeds when fertilized with wild-type pollen despite disorganized female gametophytes. In situ expression of MSP1 was detected in surrounding cells of male and female sporocytes and some flower tissues, but never in the sporocytes themselves. These results suggest that the MSP1 product plays crucial roles in restricting the number of cells entering into male and female sporogenesis and in initiating anther wall formation in rice.
De Novo Repeat Classification and Fragment Assembly (2004)

Repetitive sequences make up a significant fraction of almost any genome, and an important and still open question in bioinformatics is how to represent all repeats in DNA sequences. We propose a new approach to repeat classification that represents all repeats in a genome as a mosaic of sub-repeats. Our key algorithmic idea also leads to new approaches to multiple alignment and fragment assembly. In particular, we show that our FragmentGluer assembler improves on Phrap and ARACHNE in assembly of BACs and bacterial genomes.
Urinary Incontinence: Does it Increase Risk for Falls and Fractures? (2000)

Weekly or more frequent urge incontinence was associated independently with an increased risk of falls and non-spine, nontraumatic fractures in older women. Urinary frequency, nocturia, and rushing to the bathroom to avoid urge incontinent episodes most likely increase the risk of falling, which then results in fractures. Early diagnosis and appropriate treatment of urge incontinence may decrease the risk of fracture.