gebhart/patrepeval huggingface dataset:
Protecting the Exchange of Medical Images in Healthcare Process Integration with Web Services (2007)

There is now an increasing demand for sharing images and image data for process integration among healthcare institutions. Web services technology has recently been widely proposed and gradually adopted as a platform for supporting integrations. The Health Insurance Portability and Accountability Act (HIPAA) imposes rules as national standards to protect individuals' health information in the U.S., highlighting security and privacy protection requirements. There are so far no holistic solutions to tackle the various protection issues in this area, especially in inter-institutional healthcare progress integration. We propose the exchange of medical images through a Medical Image Exchange Platform (MIEP), especially replacing ad-hoc and manual exchange practices. We show how contemporary technologies of Web services and watermarking can help archive images with layered implementation architecture. Through dedicated Web services technologies with watermarking mechanism, not only can the development, deployment, and maintenance of software be streamlined, the privacy protection in medical image exchanges as required by disparate processes can also be much facilitated.
Cytotoxic T Cells in the Lungs of Mice Infected with an Influenza A Virus (1978)

Cytotoxic T cells are present in the lungs and the bronchoalveolar washings of mice infected intravenously (i.v.) or intranasally (i.n.) with live influenza A/WSN virus. After i.v. injection, cytotoxic T cell activity in both spleens and lungs reaches a peak at 6 days when the level of infectious virus recovered from the lungs falls sharply and the mice do not die. If a lethal dose of virus is given intranasally, very high levels of virus appear rapidly in the lungs, and the development of lung consolidation follows slightly behind the appearance of cytotoxic T cells there. When a non-lethal dose of virus is given intranasally, lower levels of virus are found in the lung and the appearance of cytotoxic T cells is delayed. These results suggest that the cytotoxic T cells play a protective role if the level of virus in the lungs does not reach very high levels. After injection of antithymocyte serum, the subsequent level of cytotoxic T cell activity in the lungs was greatly reduced, suggesting that the T cells recovered in lungs had at an earlier stage been circulating cells. However, splenectomized mice develop high levels of cytotoxic T cell activity, after intranasal infection of mice, indicating that the spleen did not contribute substantially to the T cells recovered in the lungs.
A Flexible Authorization Mechanism for Enterprise Networks Using Smart-Phone Devices (2018)

The authentication and authorization process is a critical factor in Wi-Fi enterprise networks, being the mechanism used to give access to the network resources. The general Wi-Fi enterprise network security frameworks have a static structure, being based on user-name/password credentials and without offering a flexible granular access. Nowadays, smart-phones devices are becoming ubiquitous and these can be used as security elements due to their hardware/software capabilities. Smart-phones have the capability to execute complex cryptographic operations and have the hardware peripherals, which allow authenticating the user. In this paper, we propose a smart-phone centric authentication and authorization solution which employs a bootstrap security protocols to provision temporary credentials for a WPA2 Enterprise protected Wi-Fi network.
Catecholic Flavonoids Acting as Telomerase Inhibitors (2004)

In recent years telomerase has been identified as a new promising target in oncology and consequently new telomerase inhibitors have been intensely explored as anticancer agents. Focused screening of several polyhydroxylated flavonoids has allowed us to identify 7,8,3',4'-tetrahydroxyflavone 1 as a new telomerase inhibitor with an interesting in vitro activity in a Flash-Plate assay (IC50 = 0.2 microM) that has been confirmed in the classical TRAP assay. Starting from this compound, we developed a medicinal chemistry program to optimize our lead, and in particular to replace one of the two catechols with potential bioisosteres. From this study, new structural analogues characterized by submicromolar potencies have been obtained. Their synthesis and biological activity are described.
Etching Residues of Sputtered Ta Film Using Chlorine-Based Plasma (1998)

Ta films are used as X-ray mask absorbers. Spindly etching residues of the Ta film are generated on a polished SiC film when using chlorine-based plasma. We found that etching residues were generated because of microholes which exist on the polished SiC film surface, and that etching residues generally originated from the steep slope of the substrate. For the Ta film on the Si slope, a broad peak of β-Ta(410) was observed in addition to that of β-Ta(002), which is found on the Si plane. An orientation different from β-Ta(002) appears to reduce the dry etching rate. We attempted Ar sputtering of the SiC surface to smooth the slopes in the SiC microholes. Etching residues did not originate in the case of the Ta film deposition on the polished SiC film after Ar sputtering. Therefore, Ar sputtering of polished SiC is very useful for avoiding the formation of etching residues.
PERFORMANCE OF BLIND DECONVOLUTION IN OPTOACOUSTIC TOMOGRAPHY (2011)

In this paper, we consider the use of blind deconvolution for optoacoustic (photoacoustic) imaging and investigate the performance of the method as means for increasing the resolution of the reconstructed image beyond the physical restrictions of the system. The method is demonstrated with optoacoustic measurement obtained from six-day-old mice, imaged in the near-infrared using a broadband hydrophone in a circular scanning configuration. We find that estimates of the unknown point spread function, achieved by blind deconvolution, improve the resolution and contrast in the images and show promise for enhancing optoacoustic images.
Discrete-Time Signal Processing with DNA (2013)

We present a methodology for implementing discrete-time signal processing operations, such as filtering, with molecular reactions. The reactions produce time-varying output quantities of molecules as a function of time-varying input quantities according to a functional specification. This computation is robust and independent of the reaction rates, provided that the rate constants fall within coarse categories. We describe two approaches: one entails synchronization with a clock signal, implemented through sustained chemical oscillations; the other is "self-timed" or asynchronous. We illustrate the methodology by synthesizing a simple moving-average filter, a biquad filter, and a Fast Fourier Transform (FFT). Abstract molecular reactions for these filters and transforms are translated into DNA strand displacement reactions. The computation is validated through mass-action simulations of the DNA kinetics. Although a proof of concept for the time being, molecular filters and transforms have potential applications in fields such as biochemical sensing and drug delivery.
Genetic Variations in MicroRNA-Binding Sites Affect MicroRNA-Mediated Regulation of Several Genes Associated With Cardio-metabolic Phenotypes (2015)

We provide evidence for a model in which polymorphisms in miRNA-binding sites can both positively and negatively affect miRNA-mediated regulation of cardiometabolic genes.
Cutting Edge: CD8+ Effector T Cells Reject Tumors by Direct Antigen Recognition but Indirect Action on Host Cells (2003)

CD8(+) effector T cells recognize malignant cells by monitoring their surface for the presence of tumor-derived peptides bound to MHC class I molecules. In addition, tumor-derived Ags can be cross-presented to CD8(+) effector T cells by APCs. IFN-gamma production by CD8(+) T cells is often critical for tumor rejection. However, it remained unclear whether 1) CD8(+) T cells secrete IFN-gamma in response to Ag recognition on tumor cells or APCs and 2) whether IFN-gamma mediates its antitumor effect by acting on host or tumor cells. We show in this study that CD8(+) effector T cells can reject tumors in bone marrow-chimeric mice incapable of cross-presenting Ag by bone marrow-derived APCs and that tumor rejection required host cells to express IFN-gammaR. Together, CD8(+) effector T cells recognize Ag directly on tumor cells, and this recognition is sufficient to reject tumors by IFN-gamma acting on host cells.
LIVER PRESERVATION WITH UW SOLUTION (1990)

Preservation of rat livers by simple ice-storage has been demonstrated after 24 hr using the University of Wisconsin (UW) solution. Equally good preservation could be obtained by substituting hydroxyethyl starch (HES) from another source or by omission of HES from the UW formulation. Survival, early and late function, and morphology at the end of a 3-month follow-up period were essentially similar for all three test groups. It is concluded that HES is not required for optimum preservation of the rat liver in this treatment model.
SKELETAL MUSCLE AND LIVER CHANGES IN BURNED GUINEA PIGS UNDERGOING ENTERAL FEEDING AT DIFFERENT LEVELS OF PROTEIN INTAKE (1983)

Dominioni, Lorenzo M.D.; Trocki, Orrawin R.D.; Fang, Cheng-Hui M.D.; Ray, Mukunda M.D.; Alexander, J. Wesley M.D. Author Information
Image enhancement for the visually impaired. Simulations and experimental results. (1991)

Digital image enhancement has been proposed as an aid for the visually impaired. The capability of two enhancement techniques to improve recognition of images by patients with central scotoma or cataracts was evaluated using image-processing simulations and direct patient testing. Enhancements and simulations were based on measurements of contrast sensitivity loss for patients with macular disease. Contrast sensitivity loss was measured using Gabor-type localized stimuli and paradigms that are appropriate for analyzing form perception. The simulations using the contrast sensitivity data suggested that patients with moderate visual loss (20/70-20/200) may have difficulty recognizing faces and may benefit from enhancement by both of the techniques used. Ability to recognize celebrities from enhanced images improved for 39 of the 46 patients tested. The improvement was significant (P less than 0.05) for 16 of the 38 patients with central visual loss and for 3 of 8 patients with anterior segment media opacities tested. The simulations suggest that the benefits of image enhancement may be similar or even greater for recognition of other types of images.
An Output-Capacitorless Low-Dropout Regulator With Direct Voltage-Spike Detection (2010)

An output-capacitorless low-dropout regulator (LDO) with a direct voltage-spike detection circuit is presented in this paper. The proposed voltage-spike detection is based on capacitive coupling. The detection circuit makes use of the rapid transient voltage at the LDO output to increase the bias current momentarily. Hence, the transient response of the LDO is significantly enhanced due to the improvement of the slew rate at the gate of the power transistor. The proposed voltage-spike detection circuit is applied to an output-capacitorless LDO implemented in a standard 0.35-¿m CMOS technology (where V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">THN</sub> ¿ 0.5 V and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">THP</sub> ¿ -0.65 V). Experimental results show that the LDO consumes 19 ¿A only. It regulates the output at 0.8 V from a 1-V supply, with dropout voltage of 200 mV at the maximum output current of 66.7 mA. The voltage spike and the recovery time of the LDO with the proposed voltage-spike detection circuit are reduced to about 70 mV and 3 ¿s, respectively, whereas they are more than 420 mV and 30 ¿s for the LDO without the proposed detection circuit.
Extracellular ubiquitination and proteasome-mediated degradation of the ascidian sperm receptor (2002)

The ubiquitin-proteasome system is essential for intracellular protein degradation, but an extracellular role of this system has not been known until now. We have previously reported that the proteasome is secreted into the surrounding seawater from sperm of the ascidian (Urochordata) Halocynthia roretzi on sperm activation, and that the sperm proteasome plays a key role in fertilization. Here, we show that a 70-kDa component (HrVC70) of the vitelline coat is the physiological substrate for the ubiquitin-proteasome system during fertilization of H. roretzi. A cDNA clone encoding the HrVC70 precursor (HrVC120) was isolated, and a homology search revealed that HrVC120 contains 13 epidermal growth factor-like repeats and a mammalian zona pellucida glycoprotein-homologous domain. HrVC70 functions as a sperm receptor. We demonstrate that HrVC70 is ubiquitinated both in vitro and in vivo. The immunocytochemical localization of multiubiquitin chains in the vitelline coat and the inhibitory effect of monoclonal antibodies against the multiubiquitin chains on fertilization strongly support the role of the ubiquitin-proteasome system in ascidian fertilization. Taken together, these results indicate that the ubiquitin-proteasome system is responsible for extracellular degradation of the sperm receptor HrVC70 and, consequently, for sperm penetration of the vitelline coat during fertilization.
<i>T</i><sub>1</sub> and <i>T</i><sub>2</sub> Dual-Mode MRI Contrast Agent for Enhancing Accuracy by Engineered Nanomaterials (2014)

One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here, we developed a dual-mode artifact filtering nanoparticle imaging agent (AFIA) that comprises a combination of paramagnetic and superparamagnetic nanomaterials. This AFIA has the ability to perform "AND logic gate" algorithm to eliminate false errors (artifacts) from the raw images to enhance accuracy of the MRI. We confirm the artifact filtering capability of AFIA in MRI phantoms and further demonstrate that artifact-free imaging of stem cell migration is possible in vivo.
Adenoviral gene transfer of ABIN‐1 protects mice from TNF/galactosamine‐induced acute liver failure and lethality† (2005)

Tumor necrosis factor (TNF) is a proinflammatory cytokine that plays a central role in acute and chronic hepatitis B and C infection and alcoholic liver disease as well as fulminant liver failure. TNF-induced liver failure is characterized by parenchymal cell apoptosis and inflammation leading to liver cell necrosis. The transcription factor NF-kappaB is believed to mediate at least part of the proinflammatory effects of TNF, and is therefore a favorite drug target. However, NF-kappaB also suppresses TNF-mediated hepatocyte apoptosis, implicating a potential cytotoxic effect of NF-kappaB inhibitors in the liver. This dual function of NF-kappaB emphasizes the need for therapeutics that can inhibit both TNF-induced NF-kappaB activation and cell death. Here we describe that adenoviral expression of the NF-kappaB inhibitory protein ABIN-1, but not an IkappaBalpha superrepressor (IkappaBalpha(s)), completely prevents lethality in the TNF/D-(+)-galactosamine-induced model of liver failure. Protection was associated with a significant decrease in TNF-induced leukocyte infiltration as well as hepatocyte apoptosis. The differential effects of ABIN-1 and IkappaBalpha(s) suggest a role for an NF-kappaB independent function of ABIN-1. Indeed, ABIN-1 was found to prevent not only NF-kappaB activation, but also apoptosis of cultured hepatocytes in response to TNF, explaining its protective effect against TNF-induced liver failure. In conclusion, ABIN-1 has a dual NF-kappaB inhibitory and anti-apoptotic activity in the liver, which might be of considerable interest for the treatment of inflammatory liver diseases.
Structuring by multi-beam interference using symmetric pyramids (2006)

A method for producing optical structures using rotationally symmetric pyramids is proposed. Two-dimensional structures can be achieved using acute prisms. They form by multi-beam interference of plane waves that impinge from directions distributed symmetrically around the axis of rotational symmetry. Flat-topped pyramids provide an additional beam along the axis thus generating three-dimensional structures. Experimental results are consistent with the results of numerical simulations. The advantages of the method are simplicity of operation, low cost, ease of integration, good stability, and high transmittance. Possible applications are the fabrication of photonic micro-structures such as photonic crystals or array waveguides as well as multi-beam optical tweezers.
Multiwavelength GaAs rib waveguide directional-coupler switch with ’’stepped Δβ’’ Schottky electrodes (1979)

An electro-optic waveguide directional-coupler switch has been fabricated in GaAs by liquid-phase epitaxy, photolithography, chemical etching, and electroplating. The Schottky electrodes, overlaying each single-mode rib waveguide, are cut midway along the device length to allow the electrical optimization of each switching state (’’stepped Δβ’’ configuration) in a wavelength range (1.0–1.3 μm) useful for optical-fiber communications. The device exhibits good power isolation for both states (at least 19 dB and up to 32 dB) with reverse driving voltages of less than 30 V, at 1.06, 1.15, and 1.32 μm. Both states have been obtained at 1.06 μm by switching one single voltage, a convenient way in spite of some power penalty to take full advantage of the large potential bandwidth (1 GHz) of the switch.
Proliferation in vivo and in culture of differentiated adult atrial cardiomyocytes from transgenic mice (1990)

Transgenic mice expressing atrial natriuretic factor-SV40 T-antigen fusion genes (ANF-TAG) developed unilateral right atrial tumors composed of differentiated dividing cardiomyocytes. The atrial tumors could be propagated as transplantable tumor lineages in syngeneic animals. Cardiomyocytes derived from ANF-TAG atrial tumors did not proliferate in tissue culture. However, cardiomyocytes derived from the transplantable tumor lines proliferated in culture, and these proliferating cardiomyocytes could be passaged in culture and recovered from frozen stocks. Cardiomyocytes from either tumor source were highly differentiated as determined by diverse functional and structural criteria. The cells continued to express numerous cardiac-specific proteins and retained ultrastructural features characteristic of cardiomyocytes including well-formed myofibrils, transverse tubules, and intercalated disks. In addition, the cultured cells displayed spontaneous electrical and contractile activities. These atrial tumor cardiomyocytes are a novel experimental resource for the identification of genes regulating the cardiomyocyte cell cycle.
A Comparative Study on CPU Load Predictions in a Computational Grid using Artificial Neural Network Algorithms (2015)

Background/Objectives: To evaluate the prediction accuracy of Neural Network algorithms for host CPU load prediction and evaluate their performance compared to actual values. Methods/Statistical Analysis: The speed of execution of job at the scheduled host is directly proportional to its CPU load. Therefore, target node load prediction plays an important role in job scheduling decisions. It is learnt that Neural Networks are capable of predicting the future values based on the training given on the past data. We designed a multilayer neural network and trained with learning algorithms for the input patterns collected from the load traces and predicted the future load statistics. The Mean and Standard Deviation of the predicted values are computed and analyzed against the Mean and Standard Deviation of actual values for all the ANN algorithms. Findings: We analyzed the prediction accuracy of Back Propagation, Quick Propagation, Back Propagation with Momentum and Resilient Propagation algorithm for the load traces collected from variety of computers connected in a network. Existing reports shows that Back Propagation algorithm exhibits better prediction accuracy compared to statistical approaches like linear regression and polynomial regression. In this paper, we have shown that Resilient Propagation algorithm has better prediction accuracy compared to otherANNalgorithms.Application/Improvements:Job scheduling and resource selection algorithms can employ neural network algorithms to predict the load for the sharable resources connected in the network for more accurate and faster scheduling/resource selection decision. Keywords: CPU Load Prediction, Load Traces, Neural Network Algorithms, Training, Resource Selection
Efficiency of Interprocess Communication Protocols for Computer Networks (1977)

Reliable and efficient communication in computer networks requires specialized communication protocols. Previous research has emphasized system performance at lower levels, within the communication network itself, while this work considers the efficiency of protocols for communication between processes in the host computers attached to a computer network. Throughput and delay are chosen as the primary performance measures. Network transmission characteristics, protocol parameters, and process behavior all interact in determining the efficiency of communication between remote processes. Models are developed to determine the impact of protocol parameters such as retransmission interval, window size, buffer allocation, packet size, and acknowledgment strategy on protocol performance. Several graphs showing quantitative performance results for representative situations are included.
Controlling user interface objects through pre- and postconditions (1992)

We have augmented user interface objects (i.e. windows, menus, buttons, sliders, ets.) with preconditions that determine their visibility and their enabled/disabled status and postconditions that are asserted when certain actions are performed on the object. Postconditions are associated with each functionally different action on the object. Attaching pre- and postconditions to interface objects provides several useful features, such as selective enabling of controls, rapid prototyping, and automatic generation of explanations and help text.
Theoretical studies of <i>Rhizomucor miehei</i> lipase activation (1993)

Computational methods have been used to study the extensive conformational change of Rhizomucor miehei lipase upon activation. The present study considers the possible activation route, the energies involved and molecular interactions during the conformational change of the lipase in a hydrophobic environment. The conformational change was studied by conventional molecular dynamics methods and with a combined molecular dynamics and mechanics protocol, in which the conformational change was simulated by restraining C alpha pseudotorsional angles in small steps between the two crystallographically observed positions of the lid. In the closed conformer of the enzyme the active site is completely buried under a short helical loop, 'the lid'. The activation of the lipase consists of a movement of the lid, which results in an open conformer with an exposed active site. From the results of the simulations in the present work we suggest that the lipase in a hydrophobic environment is stabilized in the open form by electrostatic interactions.