gebhart/patrepeval huggingface dataset:
Morphological evolution of three‐dimensional chemical dissolution front in fluid‐saturated porous media: a numerical simulation approach (2008)

Abstract This paper is concerned with the morphological evolution of three‐dimensional chemical dissolution fronts that occur in fluid‐saturated porous media. A fully coupled system between porosity, pore‐fluid flow and reactive chemical species transport is considered to describe this phenomenon. Using the newly presented concept of the generalized dimensionless pore fluid pressure‐gradient , which can be used to represent the interaction between solute advection, solute diffusion, chemical kinetics and the shape factor of the soluble mineral, a theoretical criterion has been established to assess the likelihood of instability at a chemical dissolution front in the reactive transport system. To simulate the chemical dissolution front evolution in a three‐dimensional fluid‐saturated porous medium, a numerical procedure combining both the finite difference method and the finite element method has been proposed. As the problem belongs to a complex system science problem, a small randomly generated perturbation of porosity is added to the initial porosity of a three‐dimensional homogeneous domain to trigger instability of a planar chemical dissolution front during its propagation within the fluid‐saturated porous medium. To test the correctness and accuracy of the proposed numerical procedure, a three‐dimensional benchmark problem has been constructed and the related analytical solution has been derived. This enables using the proposed numerical procedure for simulating the morphological evolution of a three‐dimensional chemical dissolution front from a stable, planar state into an unstable, fingering state. The related numerical results demonstrate that the proposed numerical procedure is useful for, and capable of, simulating the morphological instability of a three‐dimensional chemical dissolution front within a fluid‐saturated porous medium.
LO and behold! Concurrent structured processes (1990)

We introduce a novel concurrent logic programming language, which we call LO, based on an extension of Horn logic. This language enhances the process view of objects implementable in Horn-based concurrent logic programming languages with powerful capabilities for knowledge structuring, leading to a flexible form of variable-structure inheritance. The main novelty about LO is a new kind of OR-concurrency which is dual to the usual AND-concurrency and provides us with the notion of structured process. Such OR-concurrency can be nicely characterized with a sociological metaphor as modelling the internal distribution of tasks inside a complex organization; this complements the external cooperation among different entities accounted for by AND-concurrency.
COINCIDENCE OF EPSTEIN-BARR VIRUS REACTIVATION, CYTOMEGALOVIRUS INFECTION, AND REJECTION EPISODES IN RENAL TRANSPLANT RECIPIENTS (1995)

Reactivation of the Epstein-Barr virus was reported to occur frequently under immunosuppressive therapy following organ transplantation. However, little is known about the clinical significance of these EBV reactivations. Therefore, we searched for correlations among the treatment with various immunosuppressive drugs, the incidence of CMV infections, rejection crises, and serological signs of EBV reactivation. EBV-specific antibodies were measured with novel ELISAs, utilizing the recombinant antigens p72 (for anti-EBV nuclear antigen [EBNA]1-IgG), p54, and p138 (anti-early antigen [EA]-IgM, -IgG, -IgA) in a follow-up study of 79 renal transplant recipients. Patients receiving antithymocyte globulin or antilymphocyte globulin therapy showed increasing anti-EA-IgG and -IgA more often than did patients not receiving antithymocyte globulin or antilymphocyte globulin therapy (P < 0.05). In patients receiving OKT3 antirejection therapy, anti-EA-IgM seroconversion was found more frequently (P < 0.01). A significant correlation was also found between groups of patients who had had at least one rejection episode versus patients without any sign of organ rejection, and the incidence of increasing anti-EA-IgG (P < 0.05). Since in most of these patients signs of EBV reactivation followed the appearance of the rejection episode, this may not be due to viral-induced rejection but may be caused by the reinforced immunosuppression during antirejection therapy. As opposed to patients with no signs of CMV infection and with nonsymptomatic CMV infection, patients undergoing symptomatic CMV infection showed anti-EA-IgM seroconversion (P < 0.01), increasing anti-EA-IgA (P < 0.01), and decreasing anti-EBNA-IgG (P < 0.01) more frequently. Our results confirm the role of immunosuppressive therapy in the pathogenesis of EBV reactivation. We further demonstrate a striking coincidence of EBV reactivation and symptomatic CMV infection.
Massive Liver Growth in Mice Induced by Systemic Interleukin 6 Administration (2003)

The multifunctional cytokine interleukin 6 (IL-6) is expressed in a wide variety of disease states and pathologic processes. Mice deficient in IL-6 display abnormal and delayed liver regeneration and repair. Currently, IL-6 is thought to influence liver growth indirectly by priming hepatocytes to respond to growth factors such as hepatocyte growth factor (HGF) by inducing expression of HGF and by inhibiting hepatocyte apoptosis, as distinct from the direct mitotic effects of IL-6 on myeloid and other cell types. Here, we show that systemic administration of IL-6 using CHO cell tumors in nude mice results in dramatic hepatomegaly and hepatocyte hyperplasia in the absence of liver injury. Liver mass and liver to body mass ratios increased to 2 to 3 times normal because of proliferation of hepatocytes. Liver growth was associated with high levels of serum IL-6 and with activation of the IL-6-signaling pathway, including increased expression of IL-6 receptor-alpha/gp80, activation of the signal transducer and activator of transcription-3 (STAT-3), and mitogen-activated protein kinase (MAPK/ERK)-signaling pathways and induction of downstream target genes, including c-myc. HGF receptor and transforming growth factor alpha (TGF-alpha)/epidermal growth factor (EGF) receptor activation were decreased in hypertrophied livers, suggesting that IL-6-induced liver growth was independent of these known hepatocyte mitotic pathways. In conclusion, we suggest that IL-6 may function as a direct hepatic mitogen in vivo and, furthermore, that IL-6 warrants closer examination as a potent liver growth factor with potential clinical utility for increasing liver mass following injury.
Estimating Service Lives of Air-Purifying Respirator Cartridges for Reactive Gas Removal (2005)

A mathematical model has been developed to estimate service lives of air-purifying respirator cartridges that remove gases reactively from flowing air. Most gases, because of their high volatility and low polarizability, are not effectively removed by physical adsorption on activated carbon. Models previously developed for toxic organic vapors cannot estimate service lives of cartridges for toxic gases. Often, an activated carbon is impregnated with a chemical to enhance gas removal by chemical reaction(s). The kinds of reactions, types and amounts of impregnants, and effects of the presence of water vary; therefore, the model requires user inputs of gas capacity and water effect parameters. Ideally, these should be available from manufacturers of the cartridges. If they are not, they can be extracted from measured breakthrough times using this model. The key to this model is the observation that adsorption rates of gases can be adequately quantified by the same correlations that have been reported for organic vapors. The resulting model has been used to correlate and predict breakthrough times for several common toxic gases.
Self-assembled molecular rectifiers (1997)

Self-assembled monolayers (SAMs) of C6H5–C≡C–C6H4–C≡C–C6H4SH (1) on Au(111) and Ag(111) exhibit electrical rectifying behavior when probed by the scanning tunneling microscope whereas SAMs derived from decanethiol, benzenethiol and 4-phenylethynylbenzenethiol do not. We suggest that rectification arises from the conjugated length of the molecular framework of 1 and an increase of the donor character of the sulfur atom to this system upon adsorption to the metal. This is supported by surface second-harmonic generation measurements which show a significantly larger second order optical nonlinearity of SAMs of 1 compared to the other systems.
Flow kinetics of lactate dehydrogenase chemically attached to nylon tubing (1978)

Rabbit muscle lactate dehydrogenase (EC 1.1.1.27) was attached covalently to the inner surface of nylon tubing; a modified technique, involving benzidine and glutaraldehyde, was used, and the resulting immobilized enzyme showed no loss of activity over a period of several months. An experimental study was made of the flow kinetics for the reaction between pyruvate and reduced nicotinamide adenine dinucleotide in two limiting cases, one substrate in excess and the concentration of the other one varied. A range of flow rates and temperatures was covered. The results were analyzed in various ways on the basis of the Kobayashi--Laidler treatment of flow systems. It was concluded that the kinetics are largely diffusion-controlled, especially at the lower substrate concentrations and flow rates. The values of the apparent Michaelis constants vary with flow rate vf, being linear in vf-1/3, and the values extrapolated to infinite flow rate (vf-1/3 = 0) approach the values for the enzyme in free solution. Analysis of the rates led to activation energies for the diffusion of the two substrates.
Sulfur removal by an aqueous Claus Process (1985)

Volumetric measurements show minimal interobserver variability (0.018%) but an interscan SEM of 13.1% (confidence limits, +/- 25.6%). Repeatability and reproducibility of volumetric measurements are better than those of linear measurements reported in the literature.
PIGMENT DEPOSIT IN THE CONTRACTION FURROWS OF THE IRIS (1929)

Among the common conditions which give rise to dispersement of pigment in the eye are: (1) glaucoma, (2) trauma, (3) inflammation and (4) necrotic melanosarcoma. The fate of dispersed pigment may be : Absorption. Phagocytosis by lymphocytes. Lymphocytes, unlike polymorphonuclear leukocytes, have a tendency to agglutinate and form small masses of cells. On reaching the anterior chamber these masses precipitate to the dependent part and are seen clinically deposited on the posterior surface of the cornea. They are first grayish in color and their pigment inclusions inconspicuous. But later as the lymphocytes disintegrate, the precipitate becomes smaller and their pigment elements more conspicuous until finally these deposits appear as unadulterated pigment granules. Such is the common fate of pigment set free in uveitis. Distribution in various places as free pigment. Pigment granules have a certain tendency to agglutinate, and any such agglutinated masses may, by virtue of their
Simultaneous localization and mapping in wireless sensor networks (2014)

Mobile device localization in wireless sensor networks is a challenging task. It has already been addressed when the WiFi propagation maps of the access points are modeled deterministically or estimated using an offline human training calibration. However, these techniques do not take into account the environmental dynamics. In this paper, the maps are assumed to be made of an average indoor propagation model combined with a perturbation field which represents the influence of the environment. This perturbation field is embedded with a distribution describing the prior knowledge about the environmental influence. The device is localized with Sequential Monte Carlo methods and relies on the estimation of the propagation maps. This inference task is performed online, using the observations sequentially, with a new online Expectation Maximization based algorithm. The performance of the algorithm is illustrated with Monte Carlo experiments using both simulated data and a true data set.
The Zinspy Family of Fluorescent Zinc Sensors:  Syntheses and Spectroscopic Investigations (2004)

Four fluorescent sensors designed for Zn(II) detection that contain a fluorescein reporting group and a pyridyl-amine-thioether derivatized ligand moiety were prepared and their photophysical properties characterized. These "Zinspy" sensors are water soluble and generally display approximately 1.4- to approximately 4.5-fold fluorescence enhancement upon Zn(II) coordination, depending upon fluorescein halogenation and the number and nature of the zinc-binding appendages. The Zinspy sensors exhibit improved selectivity for zinc compared to the di-(2-picolyl)amine-based Zinpyr family.
Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps (2009)

The formation of extracellular traps (ETs) by phagocytic cells has been recognized as a novel and important mechanism of the host innate immune response against infections. ETs are formed by different host immune cells such as neutrophils, mast cells, and eosinophils after stimulation with mitogens, cytokines, or pathogens themselves, in a process dependent upon induction of a reactive-oxygen-species-mediated signaling cascade. ETs consist of nuclear or mitochondrial DNA as a backbone with embedded antimicrobial peptides, histones, and cell-specific proteases and thereby provide a matrix to entrap and kill microbes and to induce the contact system. This review summarizes the latest research on ETs and their role in innate immunity and host innate defense. Attention is also given to mechanisms by which certain leading bacterial pathogens have evolved to avoid entrapment and killing in these specialized structures.
A new efficient numerical integration scheme for highly oscillatory electric circuits (1994)

This paper presents a new numerical integration scheme for second order ordinary differential equations which can integrate highly oscillating electric circuits with high efficiency. This is shown by numerical results. The discretization scheme is based on the principle of coherence proposed by Hersch which will be described shortly. The analysis reveals important properties of the new method such as consistency. Some problems (e. g. cancellation) make an efficient implementation difficult, solutions are given.
High contrast images of uterine tissue derived using Raman microspectroscopy with the empty modelling approach of multivariate curve resolution-alternating least squares (2011)

Approaches that allow one to rapidly understand tissue structure and functionality in situ remain to be developed. Such techniques are required in many instances, including where there is a need to remove with a high degree of confidence positive tumour margins during surgical excision. As biological tissue has little contrast, gold standard confirmation of surgical margins is conventionally undertaken by histopathological diagnosis of tissue architecture via optical microscopy. Vibrational spectroscopy techniques, when coupled to sophisticated computational analyses, are capable of constructing bio-molecular contrast images of unstained tissue. To assess the relative applicability of a range of candidate algorithms to distinguish the in situ bio-molecular structures of a complex tissue, the empty modelling approach of multivariate curve resolution-alternating least squares (MCR-ALS) was compared to hierarchical cluster analysis (HCA) or principal component analysis (PCA). Such chemometric analyses were applied to Raman images of benign (tumour-adjacent) endometrium, stage I and stage II endometrioid cancer. Re-constructed images from the in situ bio-molecular tissue architectures highlighted features associated with glandular epithelium, stroma, glandular lumen and myometrium. Of the tested chemometric analyses, MCR-ALS provided the best bio-molecular contrast images, superior to those derived following HCA or PCA, with clear and defined margins of histological features. Iteratively-resolved spectra identified wavenumbers responsible for the contrast image. Wavenumbers 1234 cm(-1) (Amide III), 1390 cm(-1) (CH(3) bend), 1675 cm(-1) (Amide I/lipid), 1275 cm(-1) (Amide III), 918 cm(-1) (proline) and 936 cm(-1) (proline, valine and proteins) were responsible for generating the majority of the contrast within MCR-ALS-generated images. Applications of sophisticated computational analyses coupled with vibrational spectroscopy techniques have the potential to lend novel functionality insights into bio-molecular structures in vivo.
Frequency Deviation of Thermal Power Plants Due to Wind Farms (2006)

This paper presents the results of a study on the frequency deviation of the utility grid due to wind power fluctuations. The deviation is estimated by a deterministic method based on the transfer functions of system components. As the grid frequency is regulated, the deviation can limit high wind power penetration. The research identifies speed governors as one key component in enabling high wind penetration and there is need to factor their increased wear and tear into the ancillary services cost. It also raises the question as to whether the existing standards set for frequency deviation, which have to be complied at the points of connection of wind energy providers, are adequate to promote high wind penetration.
Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond (2019)

While ultrasound is most widely known for its use in diagnostic imaging, the energy carried by ultrasound waves can be utilized to influence cell function and drug delivery. Consequently, our ability to use ultrasound energy at a given intensity unlocks the opportunity to use the ultrasound for therapeutic applications. Indeed, in the last decade ultrasound-based therapies have emerged with promising treatment modalities for several medical conditions. More recently, ultrasound in combination with nanomedicines, i.e., nanoparticles, has been shown to have substantial potential to enhance the efficacy of many treatments including cancer, Alzheimer disease or osteoarthritis. The concept of ultrasound combined with drug delivery is still in its infancy and more research is needed to unfold the mechanisms and interactions of ultrasound with different nanoparticles types and with various cell types. Here we present the state-of-art in ultrasound and ultrasound-assisted drug delivery with a particular focus on cancer treatments. Notably, this review discusses the application of high intensity focus ultrasound for non-invasive tumor ablation and immunomodulatory effects of ultrasound, as well as the efficacy of nanoparticle-enhanced ultrasound therapies for different medical conditions. Furthermore, this review presents safety considerations related to ultrasound technology and gives recommendations in the context of system design and operation.
Sand Control: Sand Characterization, Failure Mechanisms, and Completion Methods (2002)

Abstract Sand production has historically been a problem associated with some consolidated, poorly consolidated, and unconsolidated sand formations. The result is usually lost production due to formation sand and fines plugging gravel packs, screens, perforations, tubular, and surface flow lines or separators. Completion methods applied to minimize sand production include: gravel packing, sand consolidation, critical production rate, oriented/selective perforation, FracPacking, or any combination of these methods. These techniques are used in consolidated, poorly consolidated, and unconsolidated sand formations. However, there are no guidelines available in the literature on how these methods are selected. Mechanisms for sand failure include: tensile, shear, cohesive, and pore collapse. Additionally, failure due to chemical effects can occur when the cementation materials are weakened due to chemical interactions. Many mathematical models have been presented in the literature to predict sand failure, and consequently determine sand production. These models are based on different failure mechanisms and include: pressure drawdown/compressive strength, failure based on a given failure criterion such as Mohr Coulomb, cohesive strength failure, elastoplastic failure around a perforation, viscoplastic modeling, and empirical correlations. However, there are no guidelines on how these models are applied based on the characteristics of the sand formation. Experimental studies have been presented in the literature to model sand failure. These studies include sand arching, hollow cylinder strength, triaxial and hydrostatic, and large scale testing. Laboratory testing are designed to study a given failure mechanism, and thus to predict sand production. The objective of this paper is to categorize sand formations that potentially exhibit sand failure and sand production. Based on this characterization, an appropriate laboratory testing and mathematical modeling are recommended, and a completion method is suggested. Examples from standstone reservoirs in Saudi Arabia will be used to demonstrate certain methods used for sand control.
A circuit comparison system with rule-based functional isomorphism checking (1988)

This paper describes a circuit comparison system which compares two networks and points out inconsistencies. A new approach is used to handle functionally isomorphic circuits which most conventional programs can not handle. Three techniques are included: network reduction, graph isomorphism-based comparison and rule-based functional isomorphism checking for inconsistencies. This system is efficient even for large networks and can eliminate false errors in a flexible manner.
FcR-Independent Antibody-Mediated Cellular Cytotoxicity (1991)

In this study we used palmitate-derivatized antibodies (pal-Ab) to examine the minimum contribution of Fc receptors (FcR) to macrophage (M phi)-mediated lysis and phagocytosis in antibody-dependent cellular cytotoxicity (ADCC). Pal-Ab specific for chicken erythrocytes (CE) were incorporated into the plasma membranes of M phi by insertion of the palmitate hydrocarbon chains into the outer leaflet of the phospholipid bilayer. In this system, the palmitate anchor bypassed the requirement for FcR in antibody-dependent effector-target conjugation and provided a unique opportunity to uncouple antibody-FcR interactions in ADCC. We show that binding of CE targets by P388D1 M phi effector cells through anti-CE pal-F(ab')2 can lead to efficient extracellular target cell lysis, but not phagocytosis. In contrast, pal-F(ab')2-mediated interactions between CE and peritoneal exudate M phi (PEM) activated both ingestion and extracellular lysis of the targets. In normal ADCC, FcR-dependent interactions between CE and either P388D1 cells or PEM triggered both extracellular lysis and phagocytosis. Our results demonstrate that lysis and phagocytosis in CE-directed ADCC by M phi have different minimum requirements for FcR functions. Moreover, our results suggest that FcR-independent triggers on the PEM surface are capable of triggering target cell lysis and internalization following antibody-mediated interactions.
Wide-band indoor localization effectiveness in presence of moving people (2008)

Recently, new standards have emerged in the telecommunication industry. These standards provide an open global specification that enables mobile devices to access and interact with information and services instantly. Paving the way to the emergence of new added-values services, these devices require more and more a localization agent. When deployed, these wireless resources have to operate in non-stationary propagation conditions and from outdoors to indoors. This paper concentrates on the evaluation of UWB radio signals used for localization, in presence of moving people modifying the indoor propagation channel. Different frequencies, bandwidths and densities of moving people are considered. Impacts of these parameters are evaluated on two different ranging methods: time of arrival (TOA) based and received signal strength (RSS) based.