gebhart/patrepeval huggingface dataset:
A simultaneous optimization algorithm for determining both mechanical-system and controller parameters for positioning control mechanisms (2002)

This paper presents an optimization algorithm which determines mechanical-system and controller parameters simultaneously, especially for positioning control systems. In order to improve the cost-performance ratios of products such as robots, and elevators, it is important to design them while balancing the performance of the mechanical mechanism with that of the control mechanism. The algorithm proposed in this paper does just that: it determines the mechanical parameters and how to determine the controller parameters. In the controller-design process, nonlinear programming methods are used so that large numbers of specifications and conditions can be dealt with. In the mechanism-design process, a genetic algorithm (GA) is used that allows optimal values to be obtained for complicated systems. Parameters for both mechanism and controller can be obtained by integrating these processes. The numerical result shows that the design parameters obtained satisfy the various specifications.
Design, Assembly, and Activity of Antisense DNA Nanostructures (2011)

Discrete DNA nanostructures allow simultaneous features not possible with traditional DNA forms: encapsulation of cargo, display of multiple ligands, and resistance to enzymatic digestion. These properties suggested using DNA nanostructures as a delivery platform. Here, DNA pyramids displaying antisense motifs are shown to be able to specifically degrade mRNA and inhibit protein expression in vitro, and they show improved cell uptake and gene silencing when compared to linear DNA. Furthermore, the activity of these pyramids can be regulated by the introduction of an appropriate complementary strand. These results highlight the versatility of DNA nanostructures as functional devices.
Advanced Materials Series, Wiley-scrivener (2016)

The Advanced Materials Series (AM series) published by Wiley-Scrivener Publishing, USA has comprised about 30 volumes till 2016. This series intends to provide recent advancements of the fascinating field of advanced materials science and technology, particularly in the area of structure, synthesis and processing, characterization, advanced-state properties and applications. The volumes cover theoretical and experimental approaches of molecular device materials, biomimetic materials, hybrid-type composite materials, functionalized polymers, supramolecular systems, information- and energy-transfer materials, bio based and biodegradable or environmental friendly materials. Each volume is devoted to one broad subject and the multi-disciplinary aspects are drawn out in full. Each volume is comprehensive and represents the cutting edge of science. They are written for a broad readership including researchers and students from diverse backgrounds including chemistry, physics, materials science & engineering, medical science, pharmacy, biotechnology and biomedical engineering.
Determination of Undissolved Sludge in Used Oils (1939)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTDetermination of Undissolved Sludge in Used OilsHarry Levin and Charles C. TowneCite this: Ind. Eng. Chem. Anal. Ed. 1939, 11, 4, 181–183Publication Date (Print):April 1, 1939Publication History Published online1 May 2002Published inissue 1 April 1939https://pubs.acs.org/doi/10.1021/ac50132a001https://doi.org/10.1021/ac50132a001research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies (2016)

The immune response plays a key role in enhancing the therapeutic activity of oncolytic virotherapies. However, to date, investigators have relied on inherent interactions between the virus and the immune system, often coupled to the expression of a single cytokine transgene. Recently, the importance of TLR activation in mediating adaptive immunity has been demonstrated. We therefore sought to influence the type and level of immune response raised after oncolytic vaccinia therapy through manipulation of TLR signaling. Vaccinia naturally activates TLR2, associated with an antibody response, whereas a CTL response is associated with TLR3-TRIF-signaling pathways. We manipulated TLR signaling by vaccinia through deglycosylation of the viral particle to block TLR2 activation and expression of a TRIF transgene. The resulting vector displayed greatly reduced production of anti-viral neutralizing antibody as well as an increased anti-tumor CTL response. Delivery in both naive and pre-treated mice was enhanced and immunotherapeutic activity dramatically improved.
Subunit stoichiometry of staphylococcal alpha-hemolysin in crystals and on membranes: a heptameric transmembrane pore. (1994)

Elucidation of the accurate subunit stoichiometry of oligomeric membrane proteins is fraught with complexities. The interpretations of chemical cross-linking, analytical ultracentrifugation, gel filtration, and low-resolution electron microscopy studies are often ambiguous. Staphylococcal alpha-hemolysin (alpha HL), a homooligomeric toxin that forms channels in cell membranes, was believed to possess six subunits arranged around a sixfold axis of symmetry. Here, we report that analysis of x-ray diffraction data and chemical modification experiments indicate that the alpha HL oligomer is a heptamer. Self-rotation functions calculated using x-ray diffraction data from single crystals of alpha HL oligomers show a sevenfold axis of rotational symmetry. The alpha HL pore formed on rabbit erythrocyte membranes was determined to be a heptamer by electrophoretic separation of alpha HL heteromers formed from subunits with the charge of wild-type alpha HL and subunits with additional negative charge generated by targeted chemical modification of a single-cysteine mutant. These data establish the heptameric oligomerization state of the alpha HL transmembrane pore both in three-dimensional crystals and on a biological membrane.
Blind image quality assessment (2003)

Blind image quality assessment refers to the problem of evaluating the visual quality of an image without any reference. It addresses a fundamental distinction between fidelity and quality, i.e. human vision system usually does not need any reference to determine the subjective quality of a target image. In this paper, we propose to appraise the image quality by three objective measures: edge sharpness level, random noise level and structural noise level. They jointly provide a heuristic approach of characterizing the most important aspects of visual quality. We investigate various mathematical tools (analytical, statistical and PDE-based) for accurately and robustly estimating those three levels. Extensive experiment results are used to justify the validity of our approach.
A Practical Calibration Method for Top View Image Generation (2008)

This paper describes a practical calibration method to generate a top view image from an image of a rear view camera for automobile. The geometric relation between the input and output images is described by a 3 x 3 homography matrix. Conventional methods have to use a large planar pattern to achieve precise calibration. The proposed method uses much smaller patterns, and enables to place those patterns on arbitrary positions within the view of the camera. The experimental results show that the method has equivalent calibration precision with much easier setting than the conventional methods.
Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells (2017)

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer by 2030, and the overall 5-year survival rate is currently less than 7%. Cancer cells frequently exhibit reprogramming of their metabolic activity. It is increasingly recognized that aberrant de novo lipid synthesis and reprogrammed lipid metabolism are both associated with the development and progression of various cancers, including pancreatic cancer. In this review, the current knowledge about lipid metabolism and lipid droplets in pancreatic cancer is discussed. In the first part, molecular mechanisms of lipid metabolism and roles of enzymes involved in lipid metabolism which are relevant for pancreatic cancer research are presented. Further, preclinical studies and clinical trials with drugs/inhibitors targeting cancer metabolic systems in cancer are summarized. An increase of our knowledge in lipid metabolism in pancreatic cancer cells and in tumor stroma is important for developing novel strategies of future individualized therapies of pancreatic cancer.
Loss of Heterozygosity (LOH) on Chromosomes 2q, 3p and 21q in Indian Oral Squamous Cell Carcinoma (2007)

Around the world, 200,000 people a year are affected by oral cancer, and the incidence of this disease is 10 times higher in India than Japan, mainly due to the custom of chewing tobacco. Loss of heterozygosity (LOH) on the long arm of chromosome 2 (2q), the short arm of chromosome 3 (3p) and the long arm of chromosome 21 (21q) are observed in several human cancers. We identified novel tumor suppressor loci on these regions in primary oral squamous cell carcinomas (OSCCs) in Japanese. However, there has been no detailed analysis of LOH on these chromosomes in Indians. In the present study, we investigated LOH at 2q, 3p and 21q using 9 microsatellite markers in 26 Indian OSCCs. LOH was detected in 25 (96.2%) out of 26 informative samples at one or more of the loci examined. On the basis of the results, two commonly deleted regions were identified and a detailed deletion map was constructed. In the first region, a high frequency of LOH was observed at the D3S1007 locus (53.8%) on 3p25, which is located in the region neighboring the VHL (von Hippel-Lindau) gene. In the second region, LOH was concentrated at the D3S966 locus (50.0%) on 3p21.3, suggesting the presence of a putative tumor suppressor gene (TSG) associated with OSCCs. These results strongly suggest that there are at least two candidate TSGs located on chromosome 3p, and that alteration in them is associated with the tumorigenesis of OSCCs.
Design of signal-adapted FIR paraunitary filter banks (2002)

The design of a M-band FIR paraunitary filter bank adapted to input signal statistics is considered. The adaptation criterion is energy compaction. A simple, efficient technique for computing globally optimal filter banks of arbitrary, finite degree is presented.
Hexagonal boron nitride for deep ultraviolet photonic devices (2014)

This paper provides a brief overview on recent advances in tackling the doping and optical polarization issues involved in the development of high performance deep ultraviolet (DUV) light emitting devices. In particular, recent developments in the exploitation of a novel DUV emitter layer structure based on a hexagonal boron nitride (hBN) and AlGaN p–n junction and doping engineering to potentially overcome the intrinsic problem of low p-type conductivity (or low free hole concentration) in Al-rich AlGaN are summarized. By implementing the wide bandgap and highly conductive hBN p-type layer strategy in nitride DUV emitters, p-type conductivities and DUV transparency of the electron blocking layer and p-type contact layer will be dramatically increased. This will significantly improve the free hole injection and quantum efficiency, reduce the operating voltage and heat generation, and increase the device operating lifetime. The growth of undoped and Mg-doped p-type hBN via a metal organic chemical vapor deposition technique has been studied. Furthermore, p-hBN/n-AlGaN p–n junctions have been fabricated and characterized to demonstrate the feasibility and potential of p-hBN/n-AlGaN p–n heterostructure based DUV light emitting devices. Further improvements in material quality, p-type conductivity control and device processing procedures would enhance the properties of these p–n structures, which could ultimately pave the way towards the realization of high efficiency nitride DUV photonic devices.
Partisanship and Political Clientelism in Portugal (1983–1993) (1997)

Abstract Clientelism has deep roots in the Portuguese political system. The fall of the dictatorship in 1974 and the deep changes which came afterwards did not prevent its continuity. This paper seeks to characterize political clientelism in a national perspective between 1983 and 1993, focusing on the personnel management policies pursued within three public institutions: the hospital system, Radiotelevisão Portuguesa, and the communication companies Correios, Telégrafos e Telefones and Telefones de Lisboa e Porto – both of which had a common administration.
Mandatory Relief from Administrative Action in the Federal Courts (1955)

A LONG LINE of recent federal cases the intricacies of mandamus, which are fundamentally at variance with an efficient system of judicial review of administrative action, have seriously impaired the heretofore satisfactory remedies of injunction, mandatory injunction, and declaratory judgment, even though Rule 81(b) of the Federal Rules of Civil Procedure provides that the writ of mandamus is "abolished."The case law has become so complex and so uncertain that even the simple question whether a federal district court outside the District of Columbia has original jurisdiction to grant mandatory relief is the subject of conflicting lines of cases.The law usually applied by the lower courts is directly contrary to the law usually applied by the Supreme Court which has often allowed mandatory relief in cases not arising in the District of Columbia and has never held that any district court is without jurisdiction to grant a mandatory injunction.Equity tradition calls for mandatory relief whenever the court deems it appropriate.The Administrative Procedure Act 1 specifically provides for judicial review through "writs of prohibitory or mandatory injunction," and it specifically provides that the reviewing court "shall ... compel agency action unlawfully withheld.
Parkinson's Patients with Dyskinesia Switched from Immediate Release Amantadine to Open‐label ADS‐5102 (2018)

These open-label data suggest ADS-5102 provides incremental reduction from baseline in MDS-UDPRS Part IV score in patients switched directly from amantadine IR, without exacerbating adverse events.
VPIN: User-Session Knowledge Base for Self-Management of Ambient Networks (2008)

Nowadays, diverse means of communication and multiple sorts of content are widely deployed. End users require not only service accessibility anywhere, but also transparent, personalized service adaptation to their overall context, as well as to any device and network they are using. Moreover, given the different types of mobility (user, terminal, network, and service) it is increasingly challenging to assure the dynamic adaptation of a userpsilas preferences according to location and activity. Besides these requirements, the user also wishes to be able to access the whole range of services offered in an environment. In this new telecommunications panorama, fulfilling these needs has introduced a new design for session management. An end-to-end seamless session, without service breakdowns must be provided. In this paper, we propose a VPIN (Virtual Private Information Network) based on an information model. The VPIN acts as a knowledge base for a user session. It enables the self-management of all the components in ambient networks. The conceptpsilas feasibility is illustrated and studied through a global use case.
Reflexiones acerca de la mediación en materia de consumo bajo el prisma crítico de la ley 7/2017, de 2 de noviembre (2019)

espanolLas particularidades que presenta el conflicto de consumo exigen mecanismos para su resolucion acordes al mismo. Mas alla de la buena acogida que, al efecto, esta teniendo el arbitraje de consumo, la mediacion en materia de consumo tambien existe en nuestro ordenamiento juridico y esta llamada a ser una alternativa al proceso civil, capaz de ofrecer una solucion mas rapida y eficiente. Ello es debido a la aprobacion de la Ley 7/2017, de 2 de noviembre, relativa a la resolucion alternativa de litigios en materia de consumo, que ha venido, por fin, a permitir que la mediacion pueda desarrollarse con naturalidad en el ambito de los consumidores. En consecuencia, es menester analizar la referida regulacion, en tanto conlleva novedades importantes, tanto de organizacion como de procedimiento, que deberan tenerse en cuenta a la hora hacer posible estas mediaciones. Ello no obstante, el tratamiento de esta institucion que efectua la Ley resulta cuanto menos deficiente y no exento de confusion, toda vez que no se coordina adecuadamente con la legislacion espanola que ya estaba vigente en esta materia. EnglishThe particularities that the consumer conflict presents require mechanisms for their resolution according to it. Beyond the good reception that consumer arbitration is having, consumer mediation also exists in our legal system and is called to be an alternative to the civil process, capable of offering a faster and more efficient solution. This is due to the approval of Law 7/2017, of November 2, relating to the alternative resolution of consumer litigation, which has finally come to allow mediation to develop naturally in the field of the consumers. Consequently, it is necessary to analyze the aforementioned regulation, in as much as it entails important innovations both in terms of organization and procedure, which must be taken into account when making these mediations possible. However, the treatment of this institution that makes the Law is the least deficient and not exempt from confusion, since it is not properly coordinated with the Spanish legislation that was already in force in this matter.
Immunohistochemical clues at aging of the skin microvascular unit (2008)

Specific subsets of the dermal dendrocyte populations and the blood microvasculature appear affected by aging. Capsaicin may limit these aging effects.
A prototype system for light propagation in terrains (2002)

We present a prototype system for a simple version of electromagnetic wave propagation prediction in rural areas, using a real time exploration environment for very large topographic scenes. The wave propagation prediction algorithm is based on a simple line of sight approach, realized with a modified hidden surface removal algorithm. The system serves as a transmitter management tool for interactively placing transmitters and studying the effects. Improvements according to the propagation prediction and automatic optimized placement of transmitters are current subjects of our research.
Drag Reduction of an Enclosed Rotating Disk with Fine Spiral Grooves (2005)

The purpose of this study is to obtain the new type of the drag reduction for the frictional moment of an enclosed rotating disk by using the fine spiral grooves on the disk surface. The experiments were carried out the measurement for the frictional moment of an enclosed rotating disk with fine spiral grooves, of which there were 120-160 in the number and 0.1-0.2mm in depth, respectively. The Reynolds number range is 4 × 104≤Re≤6×105. Test fluids are tap water and aqueous solutions of glycerin, It was seen that the drag reduction occurs in the turbulent flow range at the non-dimensional axial clearance (s/a) =0.011, 0.22 and 0.33, the maximum drag reduction ratio is approximately 15%. The drag reduction depends on the number, the angle and the depth of the grooves. The fine spiral groove has the effect which suppresses the development of the fluctuation of transition region, and which delays the generation of the local turbulence in the transition range.
Buried waters and internal cavities in monomeric proteins (1994)

We have analyzed the buried water molecules and internal cavities in a set of 75 high-resolution, nonhomologous, monomeric protein structures. The number of hydrogen bonds formed between each water molecule and the protein varies from 0 to 4, with 3 being most common. Nearly half of the water molecules are found in pairs or larger clusters. Approximately 90% are shown to be associated with large cavities within the protein, as determined by a novel program, PRO_ACT. The total volume of a protein's large cavities is proportional to its molecular weight and is not dependent on structural class. The largest cavities in proteins are generally elongated rather than globular. There are many more empty cavities than hydrated cavities. The likelihood of a cavity being occupied by a water molecule increases with cavity size and the number of available hydrogen bond partners, with each additional partner typically stabilizing the occupied state by 0.6 kcal/mol.
Genomics and the Acute Respiratory Distress Syndrome: Current and Future Directions (2019)

The excessive hospital mortality associated with acute respiratory distress syndrome (ARDS) in adults mandates an urgent need for developing new therapies and tools for the early risk assessment of these patients. ARDS is a heterogeneous syndrome with multiple different pathogenetic processes contributing differently in different patients depending on clinical as well as genetic factors. Identifying genetic-based biomarkers holds the promise for establishing effective predictive and prognostic stratification methods and for targeting new therapies to improve ARDS outcomes. Here we provide an updated review of the available evidence supporting the presence of genetic factors that are predictive of ARDS development and of fatal outcomes in adult critically ill patients and that have been identified by applying different genomic and genetic approaches. We also introduce other incipient genomics approximations, such as admixture mapping, metagenomics and genome sequencing, among others, that will allow to boost this knowledge and likely reveal new genetic predictors of ARDS susceptibility and prognosis among critically ill patients.