gebhart/patrepeval huggingface dataset:
The permeability of endplate channels to monovalent and divalent metal cations. (1980)

The relative permeability of endplate channels to monovalent and divalent metal ions was determined from reversal potentials. Thallium is the most permeant ion with a permeability ratio relative to Na+ of 2.5. The selectivity among alkali metals is weak with a sequence, Cs+ greater than Rb+ greater than K+ greater than Na+ greater than Li+, and permeability ratios of 1.4, 1.3, 1.1, 1.0, and 0.9. The selectivity among divalent ions is also weak, with a sequence for alkaline earths of Mg++ greater than Ca++ greater than Ba++ greater than Sr++. The transition metal ions Mn++, Co++, Ni++, Zn++, and Cd++ are also permeant. Permeability ratios for divalent ions decreased as the concentration of divalent ion was increased in a manner consistent with the negative surface potential theory of Lewis (1979 J. Physiol. (Lond.). 286: 417--445). With 20 mM XCl2 and 85.5 mM glucosamine.HCl in the external solution, the apparent permeability ratios for the alkaline earth cations (X++) are in the range 0.18--0.25. Alkali metal ions see the endplate channel as a water-filled, neutral pore without high-field-strength sites inside. Their permeability sequence is the same as their aqueous mobility sequence. Divalent ions, however, have a permeability sequence almost opposite from their mobility sequence and must experience some interaction with groups in the channel. In addition, the concentrations of monovalent and divalent ions are increased near the channel mouth by a weak negative surface potential.
Development of HIV-1 resistance to (−)2′-deoxy-3′-thiacytidine in patients with AIDS or advanced AIDS-related complex (1995)

In vitro resistance to 3TC developed in a high proportion of subjects who received prolonged monotherapy with this drug. The development of resistance to 3TC was associated with appearance of mutated viral forms and the disappearance of wild-type virus, with regard to codon 184, in both patient plasma and PBMC.
Joint RNN Model for Argument Component Boundary Detection (2017)

Argument Component Boundary Detection (ACBD) is an important sub-task in argumentation mining; it aims at identifying the word sequences that constitute argument components, and is usually considered as the first sub-task in the argumentation mining pipeline. Existing ACBD methods heavily depend on task-specific knowledge, and require considerable human efforts on feature-engineering. To tackle these problems, in this work, we formulate ACBD as a sequence labeling problem and propose a variety of Recurrent Neural Network (RNN) based methods, which do not use domain specific or handcrafted features beyond the relative position of the sentence in the document. In particular, we propose a novel joint RNN model that can predict whether sentences are argumentative or not, and use the predicted results to more precisely detect the argument component boundaries. We evaluate our techniques on two corpora from two different genres; results suggest that our joint RNN model obtain the state-of-the-art performance on both datasets.
A marked decrease in defensin mRNA in the only case of congenital neutrophil-specific granule deficiency reported in Japan. (1994)

A deficiency of defensins (human neutrophil peptides, HNP) has been previously demonstrated in two individuals with congenital neutrophil-specific granule deficiency (SGD), but its genetic basis is not well understood. We have studied another case of SGD, the only case reported in Japan, to elucidate the molecular basis of defensin deficiency. Using Western blot analysis, we showed for the first time that HNP-4, a novel human defensin, was also deficient in the patient's neutrophils. Northern blot analysis demonstrated that the defensin mRNA was absent in the bone marrow cells of the patient. Limited Southern blot analysis, using a defensin cDNA probe, did not reveal any differences in fragment patterns of the genomic DNA between the patient and the control. We propose that the defensin deficiency in our patient is a consequence of a marked decrease in defensin mRNA in neutrophil precursors. Our findings were consistent with a previous speculation suggesting that the SGD defect occurs at the level of transcription.
4-Phenoxypiperidines:  Potent, Conformationally Restricted, Non-Imidazole Histamine H<sub>3</sub> Antagonists (2005)

Two new series of 4-(1-alkyl-piperidin-4-yloxy)-benzonitriles and 4-(1-isopropyl-piperidin-4-yloxy)-benzylamines have been prepared. In vitro activity was determined at the recombinant human H(3) receptor and several members of these new series were found to be potent H(3) antagonists. The present compounds contain a 4-phenoxypiperidine core, which behaves as a conformationally restricted version of the 3-amino-1-propanol moiety common to the many previously described non-imidazole histamine H(3) ligands. One selected member of the new series, 4-[4-(1-isopropyl-piperidin-4-yloxy)-benzyl]-morpholine (13g), was found to be a potent, highly selective H(3) receptor antagonist with in vivo efficacy in a rat EEG model of wakefulness at doses as low as 1 mg/kg sc.
Conjugation of Epitope Peptides with SH Group to Branched Chain Polymeric Polypeptides via Cys(Npys) (2000)

Since bioconjugates may play an important role as therapeutics in the future, the development of new and effective conjugation strategies is necessary. For the attachment of peptide-like molecules to carriers, there are two main coupling methods involving amide or disulfide bonds. Conjugation through an amide bond can be achieved in several well-defined ways known from peptide chemistry. However, the formation of disulfide bridges between cysteine-containing peptides and carrier molecules still has some problems. In this paper, we describe a novel approach in which the carrier polypeptide is modified by 3-nitro-2-pyridinesulfenyl (Npys)-protected cysteine and this derivative has been applied for conjugation of Cys-containing epitope peptides with poly(L-lysine)-based branched polypeptides. Considering the stability of Npys group in the presence of pentafluorophenol, Boc-Cys(Npys)-OPfp dervivative was selected for introduction to the N-terminal of branches of polypeptides backbone. The branches of the polymers were built up from oligo(DL-alanine) (poly[Lys(DL-Ala(m))], AK) and elongated by an optically active amino acid [poly[Lys(X(i)-DL-Ala(m))], XAK]. We found that the nature of X (Glu, Ser, Thr) has great influence on the incorporation of the protected cysteine residue. Herpes simplex virus and adenovirus epitope peptides were conjugated to Boc-Cys(Npys)-modified polypeptides. Results indicate that the incorporation of epitope peptides depends on the number of Npys group on the polymers as well as on the presence/absence of Boc-protecting group on the Cys residue. This new class of Cys(Npys)-derivatized branched polypeptides is stable for a couple of months and suitable for effective preparation of epitope peptide conjugates possessing increased water solubility.
High‐speed multislice <i>T</i><sub>1</sub> mapping using inversion‐recovery echo‐planar imaging (1990)

Tissue contrast in MR images is a strong function of spin-lattice (T1) and spin-spin (T2) relaxation times. However, the T1 relaxation time is rarely quantified because of the long scan time required to produce an accurate T1 map of the subject. In a standard 2D FT technique, this procedure may take up to 30 min. Modifications of the echo-planar imaging (EPI) technique which incorporate the principle of inversion recovery (IR) enable multislice T1 maps to be produced in total scan times varying from a few seconds up to a minute. Using IR-EPI, rapid quantification of T1 values may thus lead to better discrimination between tissue types in an acceptable scan time.
Mild and Highly Efficient Method for the Synthesis of 2-Arylbenzimidazoles and 2-Arylbenzothiazoles (2008)

A new, convenient method for the syntheses of 2-substituted benzimidazole and benzothizole is described. Short reaction times, large-scale synthesis, easy and quick isolation of the products, excellent chemoselectivity, and excellent yields are the main advantages of this procedure.
Issues in multimedia interface design: media integration and interface agents (1990)

A central challenge in the design of multimedia databases is integrating information from different media sources while reducing the cognitive load imposed on users by the tasks of learning and operating the interface. In light of results from a prototype multimedia project developed at Apple, we believe that an agent-style interface addresses this challenge in several ways. This paper discusses techniques for achieving media integration and details the use of interface agents in facilitating 'navigation', enhancing content through point of view, and supporting users in a variety of instrumental and experiential tasks.
Electric field effects on human spinal injury: Is there a basis in the <i>in vitro</i> studies? (2007)

Abstract An important basis for the clinical application of small DC electric current to mammalian spinal injury is the responses of neurons in culture to applied electric fields. Our recent finding that zebrafish neurons were unresponsive to applied fields prompted us to critically examine previous results. We conclude that compelling evidence for neuronal guidance and directional stimulation of growth toward either the cathode or anode in an electric field exists only for cultured Xenopus neurons, and not for any mammalian neurons. No basis for the reported success in treating spinal injury exists in the in vitro studies, and considerable research will be required if the conditions of field application in mammalian spinal injury are to be optimized. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2008
Advantages and applications of the centerline method for characterizing regional ventricular function. (1986)

We sought to identify theoretical advantages and applications of the centerline method for quantitative assessment of regional ventricular function. Motion was measured along 100 chords constructed perpendicular to a centerline drawn midway between the end-diastolic and end-systolic contours, and normalized for heart size. Abnormality was expressed in units of standard deviations from the mean motion in a normal reference population to indicate both the severity and significance of the wall motion abnormality. The mean abnormality averaged over 100 chords correlated highly with the area ejection fraction (r = .97). The centerline method uses a "sliding window" to measure motion where it is abnormal, because assessment of wall motion in predefined regions of the ventricular contour underestimates abnormality. From the 100 data points, the extent (% of contour) of regional abnormalities can also be determined. The severity of hypokinesis at the site of acute myocardial infarction correlated better with infarct size estimated from creatine kinase release (r = -.78) than did the ejection fraction or the circumferential extent of hypokinesis. Because the centerline method measures motion along locally determined vectors, and requires no apex, origin, coordinate system, or geometric reference figure, it can be applied to contours as dissimilar as the 60 degree left anterior oblique projection of the left ventricle and the 75 degree left anterior oblique projection of the right ventricle.
On the enzymic defects in hereditary tyrosinemia. (1977)

The activity of the enzyme porphobilinogen synthase (EC 4.2.1.24) in erythrocytes from patients with hereditary tyrosinemia was less than 5% of that in a control group and the activity in liver tissue was less than 1% of the reported normal activity. Urine from patients with hereditary tyrosinemia contained an inhibitor that was isolated and identified as succinylacetone (4,6-dioxoheptanoic acid) by gas/liquid chromatography-mass spectrometry. Fresh urine samples contained succinylacetoacetate (3,5-dioxooctanedioic acid) as well as succinylacetone. The inhibition of porphobilinogen synthase explains the high excretion of 5-aminolevulinate observed in hereditary tyrosinemia. Succinylacetone and succinylacetoacetate presumably originate from maleylacetoacetate or fumarylacetoacetate, or both, and their accumulation indicates a block at the fumarylacetoacetase (EC 3.7.1.2) step in the degradation of tyrosine. We suggest that the severe liver and kidney damage in hereditary tyrosinemia may be due to the accumulation of these tyrosine metabolites and that the primary enzyme defect in hereditary tyrosinemia may be decreased activity of fumarylacetoacetase.
Single Crystal Growth and Characterizations of A<sub>3</sub>BC<sub>3</sub>D<sub>2</sub>O<sub>14</sub>-Type Compounds for Piezoelectric Applications (2001)

A 3 Nb 1- x Ga 3+(5/3) x Si 2 O 14 (ANGS, A=Sr, Ca) compounds were investigated as a function of Nb and Ga mole ratios and grown using the micro pulling-down (µ-PD) technique after being prepared by the conventional solid-state reaction. On the basis of the µ-PD growth results, ANGS single crystals were grown by the Czochralski method. The grown Sr 3 NbGa 3 Si 2 O 14 (SNGS) and Ca 3 NbGa 3 Si 2 O 14 (CNGS) the single crystals showed that they were isostructural to that of A 3 BC 3 D 2 O 14 , which had the space group P321. The lattice parameters of SNGS and CNGS were calculated to be a =8.282, 8.087 and c =5.073, 4.980 Å, respectively. The defect distribution and piezoelectric properties of these crystals were measured.
<title>Squeezing light out of crystals: triboluminescent sensors</title> (1999)

Currently, there are no simple sensing techniques for determining in real-time both the severity and location of structural damage in a composite caused by a dynamic impact event. Materials are known which emit light when they are fractured. This fracture-induced light emissions is known as triboluminescence. A triboluminescent material embedded in, or attached on, a composite structure could act as a real- time damage sensor. The occurrence and severity of the damage is given by the intensity of the resulting triboluminescent light. Since the triboluminescent light emission is fracture-initiated, no signal would be generated by a triboluminescent sensor until damage had actually occurred. Hence no false alarms are generated by this type of sensor. An array of triboluminescent sensors may allow real-time damage location monitoring simply by determining the wavelength of the emitted light. We have developed a series of highly efficient triboluminescent materials with sufficient thermal and chemical properties to allow doping into composites. We report a series of proof-of-principle experiments with these materials which strongly support the potential of triboluminescent sensors to monitor in real- time both the magnitude and location of structural damage.
The Holo-Diagram IV: A Practical Device for Simulating Fringe Patterns in Hologram Interferometry (1971)

A new simple moiré equivalence to hologram interferometry has been investigated. We have found this equivalence to be very useful as an educational tool. The analogy to any interference pattern can be projected before a large auditorium using an ordinary overhead projector, and the fringes can be studied directly during formation. The equivalence is rather easily understood as it is only based on the loci of constant pathlength for the light traveling from the light source to the observer via the object. No, or very little, mathematical, optical, or linguistic preknowledge is needed, because the ellipsoids onto which the method is based can be demonstrated using just two nails and a string. The new equivalence method is also being tested in a simple analog computer, which, we hope, will be used as the holographer’s sliderule.
Roles of NHERF1/EBP50 in Cancer (2008)

This review summarizes the emerging roles of NHERF1/EBP50 adaptor protein in tumorigenesis. NHERF1/EBP50 (Na(+)/H(+) exchanger regulating factor 1; ezrin-radixin-moesin (ERM) binding phosphoprotein of 50 kDa) is a PDZ domain-containing protein with physiological localization at the plasma membrane. We discuss in this review the functions of NHERF1/EBP50 as a linker between membrane proteins and the cytoskeleton network, as well as its involvement in different types of cancer, such as breast and liver cancers. Recent evidence obtained from our laboratory and from other groups shows that NHERF1/EBP50 is an important player in cancer progression. It appears that, depending on its subcellular distribution, NHERF1/EBP50 may behave either as a tumor suppressor, when it is localized at the plasma membrane, or as an oncogenic protein, when it is shifted to the cytoplasm. We provide here an overview of the mechanisms by which this adaptor protein controls cell transformation, and propose a model suggesting a dual role of NHERF1/EBP50 in cancer.
Production of fungal chitosan in liquid cultivation using apple pomace as substrate (2009)

In this work, we propose the reuse of apple pomace as a substrate for fungal chitosan production by liquid cultivation of Gongronella butleri CCT4274. Different concentrations of reducing sugars and sodium nitrate were added to the aqueous extract of apple pomace and the best result was obtained with 40 g/L of reducing sugars and 2.5 g/L of sodium nitrate. The results indicate the possibility of producing 1.19 g/L of chitosan per liter of culture medium after 72.5 hours of cultivation, representing around 21% of the biomass content.
Interactive Vegetation Rendering with Slicing and Blending (2000)

Detailed and interactive 3D rendering of vegetation is one of the challenges of traditional polygon-oriented computer graphics, due to large geometric complexity even of simple plants. In this paper we introduce a simplified image-based rendering approach based solely on alpha-blended textured polygons. The simplification is based on the limitations of human perception of complex geometry. Our approach renders dozens of detailed trees in real-time with off-the-shelf hardware, while providing significantly improved image quality over existing real-time techniques. The method is based on using ordinary mesh-based rendering for the solid parts of a tree, its trunk and limbs. The sparse parts of a tree, its twigs and leaves, are instead represented with a set of slices, an imagebased representation. A slice is a planar layer, represented with an ordinary alpha or color-keyed texture; a set of parallel slices is a slicing. Rendering from an arbitrary viewpoint in a 360 degree circle around the center of a tree is achieved by blending between the nearest two slicings. In our implementation, only 6 slicings with 5 slices each are sufficient to visualize a tree for a moving or stationary observer with the perceptually similar quality as the original model.
PLC Optical Equalizer for Chromatic and Polarization-Mode Dispersion Compensation Based on MSE Control (2004)

A planar lightwave circuit optical equalizer, based on the minimum mean square error control criterion, is proposed for simultaneous chromatic and polarization-mode dispersion (PMD) compensation. The working principle of the device is explained by means of two equivalent representations, and its performance against chromatic dispersion and PMD is evaluated.
Axial-flux permanent-magnet machine modeling, design, simulation and analysis (2011)

Axial-flux permanent-magnet machines today are important technology in many applications, where they are an alternative to radial-flux permanent-magnet machines. Reviewed here are technology status and advances/trends in axial-flux permanent-magnet machines, in aspects of construction, features, modeling, simulation, analysis, and design procedure. Potential applications and future trends are also discussed.
Intensive Linkage Mapping in a Wasp (<i>Bracon hebetor</i>) and a Mosquito (<i>Aedes aegypti</i>) With Single-Strand Conformation Polymorphism Analysis of Random Amplified Polymorphic DNA Markers (1996)

The use of random amplified polymorphic DNA from the polymerase chain reaction (RAPD-PCR) allows efficient construction of saturated linkage maps. However, when analyzed by agarose gel electrophoresis, most RAPD-PCR markers segregate as dominant alleles, reducing the amount of linkage information obtained. We describe the use of single strand conformation polymorphism (SSCP) analysis of RAPD markers to generate linkage maps in a haplodiploid parasitic wasp Bracon (Habrobracon) hebetor and a diploid mosquito. Aedes aegypti. RAPD-SSCP analysis revealed segregation of codominant alleles at markers that appeared to segregate as dominant (band presence/band absence) markers or appeared invariant on agarose gels. Our SSCP protocol uses silver staining to detect DNA fractionated on large thin polyacrylamide gels and reveals more polymorphic markers than agarose gel electrophoresis. In B. hebetor, 79 markers were mapped with 12 RAPD primers in six weeks; in A aygpti, 94 markers were mapped with 10 RAPD primers in five weeks. Forty-five percent of markers segregated as codominant loci in B. hebetor, while 11% segregated as codominant loci in A. aegypti. SSCP analysis of RAPD-PCR markers offers a rapid and inexpensive means of constructing intensive linkage maps of many species.
Subfemtojoule deep submicrometer-gate CMOS built in ultra-thin Si film on SIMOX substrates (1991)

A deep submicrometer gate MOSFET with fully depleted channel was fabricated using ultrathin Si film on SIMOX (separation by implanted oxygen) substrates. Ultrathin films with thicknesses down to 30 nm are shown to be effective in reduction of the short-channel effect. Thus, deep submicrometer gate MOSFETs with steep subthreshold slopes and threshold voltages insensitive to drain voltage were realized. The propagation delay of a CMOS inverter on an ultrathin SIMOX substrate was measured by a 51-stage ring oscillator configuration, with a 0.25- mu m gate built in 100-nm-thickness Si film. The delay was 21.5 ps per gate at room temperature for a supply voltage of 2.5 V. With 30-nm Si film, the CMOS ring oscillators demonstrated a power-delay product of 0.5 fJ for a supply voltage of 1.5 V, also at room temperature.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Predicting, Explaining, and Preventing Children's Reading Difficulties (2001)

Several decades of research have made it clear that by the time children enter school they already vary widely in their reading‐related knowledge and skills. How well do these differences predict differences in reading acquisition? What can they tell us about the causes of reading disabilities? How might these research findings be used to reduce the number of children who have difficulty learning to read? Answers to such questions are fundamental for designing early interventions for children at risk. In this paper, we summarize what has been learned so far, and discuss what directions need to be taken in future research so as to provide fuller answers.