gebhart/patrepeval huggingface dataset:
Effects of extracellular signal-regulated kinase (ERK) on focal cerebral ischemia. (2003)

ERK plays an important role in focal cerebral ischemia and inhibition of the ERK pathway can help protect against ischemic brain injury, which may provide a therapeutic approach for cerebral ischemia.
The Cell Wall Sensors Mtl1, Wsc1, and Mid2 Are Required for Stress-Induced Nuclear to Cytoplasmic Translocation of Cyclin C and Programmed Cell Death in Yeast (2013)

Mtl1 is a member of a cell wall sensor family that monitors cell wall integrity in budding yeast. In response to cell wall stress, Mtl1 activates the cell wall integrity (CWI) MAP kinase pathway which transmits this signal to the nucleus to effect changes in gene expression. One target of the CWI MAP kinase is cyclin C, a negative regulator of stress response genes. CWI activation results in cyclin C relocalization from the nucleus to the cytoplasm where it stimulates programmed cell death (PCD) before it is destroyed. This report demonstrates that under low oxidative stress conditions, a combination of membrane sensors, Mtl1 and either Wsc1 or Mid2, are required jointly to transmit the oxidative stress signal to initiate cyclin C destruction. However, when exposed to elevated oxidative stress, additional pathways independent of these three sensor proteins are activated to destroy cyclin C. In addition, N-glycosylation is important for Mtl1 function as mutating the receptor residue (Asn42) or an enzyme required for synthesis of N-acetylglucosamine (Gfa1) reduces sensor activity. Finally, combining gfa1-1 with the cyclin C null allele induces a severe synthetic growth defect. This surprising result reveals a previously unknown genetic interaction between cyclin C and plasma membrane integrity.
Monoclonal antibody to endotoxin attenuates hemorrhage-induced lung injury and mortality in rats (1997)

These data suggest that a) endotoxin derived from enteric bacteria might play an important role in the pathogenesis of lung injury; and b) antiendotoxin agents, such as WN1 222-5, appear to protect against endogenous bacterial endotoxin-related disorders in severe hemorrhagic shock in rats.
The principles of laser beam control with polarization gratings introduced as diffractive waveplates (2010)

The development history of polarization gratings (PGs), with origins in holography and Bragg gratings, accentuated and reinforced their perception as gratings. We highlight their nature as waveplates - diffractive waveplates (DWs) - and stress their family connection to vector vortex waveplates. This approach provides a straightforward understanding of the unusual properties of PGs, such as nearly 100% diffraction in thin material layers, the presence of only one diffraction order for a circularly polarized beam, wide diffraction bandwidth and the possibility of achromatic behavior. With technology being ripe for applications such as beam steering, and optical switching, we characterize the resistance of DWs to optical radiation, the effects of temperature and deformations. We also show that the boundary effects in the manufacturing process make it necessary to use substrates larger than the desired aperture of the DW. The multicomponent systems are discussed for developing normally transmissive switchable imaging systems, beam scanning, and achromatic diffraction.
Cervical pessaries for prevention of spontaneous preterm birth: past, present and future (2013)

This Review describes the rationale for the use of cervical pessaries to prevent spontaneous preterm birth and their gradual introduction into clinical practice, discusses technical aspects of the more commonly used designs and provides guidance for their use and future evaluation. Possible advantages of cervical pessaries include the easy, 'one-off' application, good side-effect profile, good patient tolerance and relatively low cost compared with current alternatives. Use of transvaginal sonography to assess cervical length in the second trimester allows much better selection of patients who may benefit from the use of a cervical pessary, but future clinical trials are needed to establish clearly the role of pessaries as a preterm birth prevention strategy worldwide.
Advanced Navigation System for Aircraft Applications (2013)

Various forms of navigation are present in today’s world, leading from satellite based navigation to several archaic forms of navigation like star gazing. Now, lots of technologies are available to achieve this but with certain limitations. For example, FOG based navigation provides accuracy with in 0.10-100 range which is not sufficient for various military applications. Therefore, there is a need to design a system which will have better accuracy and thus requires development of ring laser gyro-based inertial systems. This paper concentrates on the aided navigation system based on ring laser gyro of 0.01 deg/hr class and GPS - GLONASS to further enhance the capability of system in terms of accuracy. The usage of such systems not only provides accurate results momentarily but it also persists for longer duration with the aid of GPS - GLONASS for applications like aircraft, ship and long range missiles. The system provides accuracy of the level of 1 Nm/hr in pure navigation and 30 m with the aid of GPS - GLONASS. Apart from this, the availability of gyro-compass and baro-inertial algorithms further enhances the system capabilities and made them self dependent to the major extent. Defence Science Journal, 2013, 63(2), pp.131 -137 , DOI:http://dx.doi.org/10.14429/dsj.63.4254
Neurosteroid Analogues. 8. Structure−Activity Studies of <i>N</i>-Acylated 17a-Aza-D-homosteroid Analogues of the Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one (2000)

ADVERTISEMENT RETURN TO ISSUELetterNEXTNeurosteroid Analogues. 8. Structure−Activity Studies of N-Acylated 17a-Aza-D-homosteroid Analogues of the Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-oneDouglas F. Covey, Mingcheng Han, A. Sampath Kumar, Maria Antonette M. de la Cruz, Eric S. Meadows, Yuefei Hu, Alicia Tonnies, Devi Nathan, Melissa Coleman, Ann Benz, Alex S. Evers, Charles F. Zorumski, and Steven MennerickView Author Information Departments of Molecular Biology and Pharmacology, Anesthesiology, Psychiatry, and Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110 Cite this: J. Med. Chem. 2000, 43, 17, 3201–3204Publication Date (Web):August 5, 2000Publication History Received8 June 2000Published online5 August 2000Published inissue 1 August 2000https://pubs.acs.org/doi/10.1021/jm0002477https://doi.org/10.1021/jm0002477rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views439Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Carbonyls,Conformation,Hydrogen,Receptors,Steroids Get e-Alerts
La parole est fondamentalement une action et la démocratie une compétence (2004)

revue de l'OCCE
On line predictive appearance-based tracking (2005)

We present a novel predictive statistical framework to improve the performance of an eigentracker. In addition, we use fast and efficient eigenspace updates to learn new views of the object being tracked on the fly. We also incorporate a new importance sampling mechanism which increases the robustness of the eigentracker and enables it to track nonconvex objects better. Our eigentracker is flexible-it is possible to use it symbolically with other trackers. We show its successful application in hand gesture analysis; and face and person tracking.
Higher-order clustering in networks (2018)

A fundamental property of complex networks is the tendency for edges to cluster. The extent of the clustering is typically quantified by the clustering coefficient, which is the probability that a length-2 path is closed, i.e., induces a triangle in the network. However, higher-order cliques beyond triangles are crucial to understanding complex networks, and the clustering behavior with respect to such higher-order network structures is not well understood. Here we introduce higher-order clustering coefficients that measure the closure probability of higher-order network cliques and provide a more comprehensive view of how the edges of complex networks cluster. Our higher-order clustering coefficients are a natural generalization of the traditional clustering coefficient. We derive several properties about higher-order clustering coefficients and analyze them under common random graph models. Finally, we use higher-order clustering coefficients to gain new insights into the structure of real-world networks from several domains.
Image compression Using A Neural Network (2005)

Data compression of speckled images poses a non-trivial model identification problem. We train an unsupervised neural network on a set of archetype images in order to form an internal representation (or model) of the image features. We find that a multi-layer topographic mapping network has the necessary properties successfully to compress and reconstruct imagery. We show how to extend and improve upon existing learning algorithms for this type of network, and we express the network learning dynamics as a diffusion equation. We then present some examples of the application of this technique to synthetic aperture radar images.
CXCR6, a Newly Defined Biomarker of Tissue-Specific Stem Cell Asymmetric Self-Renewal, Identifies More Aggressive Human Melanoma Cancer Stem Cells (2010)

The association of a more aggressive tumor phenotype with asymmetric self-renewal phenotype reveals a previously unrecognized aspect of tumor cell physiology. Namely, the retention of some tissue-specific stem cell attributes, like the ability to asymmetrically self-renew, impacts the natural history of human tumor development. Knowledge of this new aspect of tumor development and progression may provide new targets for cancer prevention and treatment.
Production of Miniature Glass Cells with Rubidium for Chip Scale Atomic Clock (2015)

The main advantage of chip scale atomic clock (e.g., Knappe (2008)) (CSAC) over quartz-oscillators is the higher long-term stability. It is provided by non-aging resonance of unperturbed atoms. However it is not a simple task to suppress all possible perturbations. Hence, metrological properties of resonance depend on the way in which ensemble of atoms is localized in space and protected. The paper describes a technology of small all-glass Rb cells production. The sealing of cells is made with radiation of a СО2 lasers. The cells will be utilized in Rb CSAC based on the phenomenon of coherent population trapping (CPT). (Pat. No RU 2014101361)
Transmission line detection using deep convolutional neural network (2019)

The bottom of the overhead transmission line is easily affected by external environmental factors such as temperature, wind, snow and so on, thus fluctuating up and down. There is a great significance of the timely monitoring of the bottom position of the transmission line for the safe and stable operation of the transmission line. Recent years, the computer vision researches based on deep learning develop rapidly and have achieved remarkable performance. In this paper, a deep convolutional neural network (CNN) is proposed to locate the bottom position of the transmission lines. The experiment shows that our network model attained a highest identification accuracy of 99.89%. Moreover, the experiment adopts four-way parallel processing technology. Compared with other traditional methods, our proposed method can save a lot of time and have high prediction accuracy.
Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease (2017)

Neurodegenerative diseases are a devastating group of conditions that cause progressive loss of neuronal integrity, affecting cognitive and motor functioning in an ever-increasing number of older individuals. Attempts to slow neurodegenerative disease advancement have met with little success in the clinic; however, a new therapeutic approach may stem from classic interventions, such as caloric restriction, exercise, and parabiosis. For decades, researchers have reported that these systemic-level manipulations can promote major functional changes that extend organismal lifespan and healthspan. Only recently, however, have the functional effects of these interventions on the brain begun to be appreciated at a molecular and cellular level. The potential to counteract the effects of aging in the brain, in effect rejuvenating the aged brain, could offer broad therapeutic potential to combat dementia-related neurodegenerative disease in the elderly. In particular, results from heterochronic parabiosis and young plasma administration studies indicate that pro-aging and rejuvenating factors exist in the circulation that can independently promote or reverse age-related phenotypes. The recent demonstration that human umbilical cord blood similarly functions to rejuvenate the aged brain further advances this work to clinical translation. In this review, we focus on these blood-based rejuvenation strategies and their capacity to delay age-related molecular and functional decline in the aging brain. We discuss new findings that extend the beneficial effects of young blood to neurodegenerative disease models. Lastly, we explore the translational potential of blood-based interventions, highlighting current clinical trials aimed at addressing therapeutic applications for the treatment of dementia-related neurodegenerative disease in humans.
A penalized-likelihood image reconstruction method for emission tomography, compared to postsmoothed maximum-likelihood with matched spatial resolution (2003)

Regularization is desirable for image reconstruction in emission tomography. A powerful regularization method is the penalized-likelihood (PL) reconstruction algorithm (or equivalently, maximum a posteriori reconstruction), where the sum of the likelihood and a noise suppressing penalty term (or Bayesian prior) is optimized. Usually, this approach yields position-dependent resolution and bias. However, for some applications in emission tomography, a shift-invariant point spread function would be advantageous. Recently, a new method has been proposed, in which the penalty term is tuned in every pixel to impose a uniform local impulse response. In this paper, an alternative way to tune the penalty term is presented. We performed positron emission tomography and single photon emission computed tomography simulations to compare the performance of the new method to that of the postsmoothed maximum-likelihood (ML) approach, using the impulse response of the former method as the postsmoothing filter for the latter. For this experiment, the noise properties of the PL algorithm were not superior to those of postsmoothed ML reconstruction.
<i>trans</i>-2-Phenylcyclopropylamine Is a Mechanism-Based Inactivator of the Histone Demethylase LSD1 (2007)

The catalytic domain of the flavin-dependent human histone demethylase lysine-specific demethylase 1 (LSD1) belongs to the family of amine oxidases including polyamine oxidase and monoamine oxidase (MAO). We previously assessed monoamine oxidase inhibitors (MAOIs) for their ability to inhibit the reaction catalyzed by LSD1 [Lee, M. G., et al. (2006) Chem. Biol. 13, 563-567], demonstrating that trans-2-phenylcyclopropylamine (2-PCPA, tranylcypromine, Parnate) was the most potent with respect to LSD1. Here we show that 2-PCPA is a time-dependent, mechanism-based irreversible inhibitor of LSD1 with a KI of 242 microM and a kinact of 0.0106 s-1. 2-PCPA shows limited selectivity for human MAOs versus LSD1, with kinact/KI values only 16-fold and 2.4-fold higher for MAO B and MAO A, respectively. Profiles of LSD1 activity and inactivation by 2-PCPA as a function of pH are consistent with a mechanism of inactivation dependent upon enzyme catalysis. Mass spectrometry supports a role for FAD as the site of covalent modification by 2-PCPA. These results will provide a foundation for the design of cyclopropylamine-based inhibitors that are selective for LSD1 to probe its role in vivo.
The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching (2008)

Blood vessel formation requires the integrated regulation of endothelial cell proliferation and branching morphogenesis, but how this coordinated regulation is achieved is not well understood. Flt-1 (vascular endothelial growth factor [VEGF] receptor 1) is a high affinity VEGF-A receptor whose loss leads to vessel overgrowth and dysmorphogenesis. We examined the ability of Flt-1 isoform transgenes to rescue the vascular development of embryonic stem cell-derived flt-1-/- mutant vessels. Endothelial proliferation was equivalently rescued by both soluble (sFlt-1) and membrane-tethered (mFlt-1) isoforms, but only sFlt-1 rescued vessel branching. Flk-1 Tyr-1173 phosphorylation was increased in flt-1-/- mutant vessels and partially rescued by the Flt-1 isoform transgenes. sFlt-1-rescued vessels exhibited more heterogeneous levels of pFlk than did mFlt-1-rescued vessels, and reporter gene expression from the flt-1 locus was also heterogeneous in developing vessels. Our data support a model whereby sFlt-1 protein is more efficient than mFlt-1 at amplifying initial expression differences, and these amplified differences set up local discontinuities in VEGF-A ligand availability that are important for proper vessel branching.
Voltage‐gated potassium channels: from hyperexcitability to excitement (1999)

The superfamily of voltage-activated potassium channels may express structurally and functionally diverse voltage-activated potassium channels in the nervous system. The roles of some voltage-activated potassium channel types, e.g. rapidly inactivating (transiently active type) channels and muscarine sensitive muscarine sensitive channels, are beginning to be understood. They may significantly influence dendritic action-potential back-propagation, signal to noise ratios in presynaptic excitability or the responsiveness of a neuron to synaptic input. Inherited disorders related to changes in excitability (episodic ataxia, epilepsy, heart arrhythmia) or to defects in sensory perception (hearing loss) have been associated with mutations in a few voltage-activated potassium channel genes. Most likely, more voltage-activated potassium channel genes will be linked to related disorders in the near future.
The Input Model of Standard Graphics Systems Revisited by Formal Specification (1992)

Abstract This paper describes the specification of an input model for graphics systems. The initial aim of the work reported in this paper was to revise the input model adopted by graphics standards by means of formal specification techniques in order to acquire a deep knowledge of its capabilities, to eventually discover errors and to develop improvements. Taking into account similar works done in this area by others and considering a number of major issues related to input recently discussed within the graphics community, a new model is being proposed that addresses the very key concepts of parallelism, extensibility and reconfigurability. The model is based upon composition operations defined over basic components specified as a set of concurrent processes. Composition operations and process definitions have been formally specified by using the LOTOS notation and investigated by means of the LOTOS Interactive Tools Environment. In the first part of the paper, the input model of graphics standards is shortly examined in the light of the results so far achieved by related works on formal specification of computer graphics systems. Subsequently, an improved model is presented. Finally, its capability of simulating the traditional operating modes of logical input devices and a methodology for defining new operating modes is demonstrated.
Electrochemical Reactions in Adsorption of Organosulfur Molecules on Gold and Silver:  Potential Dependent Adsorption (2000)

The early stage of adsorption of organosulfur molecules on gold and silver was investigated by electrochemical and quartz crystal microgravimetric methods. The potential shifts of the substrate metals, current flowing through the substrates, and the surface mass increase observed during the adsorption process were found to support newly proposed electrochemical mechanisms of chemisorption steps: Thiols adsorb on Au and Ag by an anodic oxidation, whereas dialkyl disulfides adsorb through a reaction that results in net cathodic current. The relative rates of the adsorption depended on the potential of the substrate in accordance with the electrochemical mechanisms. The increase in surface mass due to adsorption was observed to closely parallel the charge expended in the electrochemical reactions.
Smart labels-high volume applications using adhesive flip-chip-technologies (2002)

The authors present requirements, conditions and experiences for the production of smart labels in a reel-to-reel assembly technique. They compare different adhesive flip-chip technologies as well as different types of adhesives for smart label production schemes. Technology advantages for low cost substrates like PET in combination with copper or aluminium antenna tracks are presented. Besides the technology and material adaptations, electrical and mechanical properties of flip-chip interconnections are presented. In the last part of the paper, the authors present a new generation of smart labels-active working smart labels. These labels include a battery and additional electronic functions.
Cross‐sectional study of patients fitted with fixed partial dentures with special reference to the caries situation (1990)

The caries situation among 30 patients with fixed partial dentures was examined 3 yr after cementation of the constructions. The fit of the crowns on the abutment teeth, the size of the interproximal areas and the relation between the crown margin and the gingival margin were registered. Risk factors for caries development, such as salivary factors, microbiologic factors, oral hygiene and diet were evaluated for each patient. During the 3-yr period 54 caries lesions occurred in 25 patients. Eleven lesions were found on abutment teeth. Two were located on the root surfaces unconnected with the crown margin (greater than 2mm from the gingival margin), three were recurrent lesions, where the crown margin was located above the gingival margin but closer than 2 mm and six were recurrent lesions where the crown margin was located under the gingival margin. No single caries risk factor seemed to be so closely correlated to the number of caries lesions developed that it could be used alone to select of patients at risk. When the sum of the assumed negative factors was used, more caries was found among the patients with three or more factors with negative values in the group as a whole. However, predicting the development of caries in an individual case with a high degree of probability seems to be complicated. Generally speaking there was no indication that caries disease development was caused by the presence of the fixed partial denture per se.