gebhart/patrepeval huggingface dataset:
Novel concatameric heparin-binding peptides reverse heparin and low-molecular-weight heparin anticoagulant activities in patient plasma in vitro and in rats in vivo (2003)

Patients given unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) for prophylaxis or treatment of thrombosis sometimes suffer serious bleeding. We showed previously that peptides containing 3 or more tandem repeats of heparin-binding consensus sequences have high affinity for LMWH and neutralize LMWH (enoxaparin) in vivo in rats and in vitro in citrate. We have now modified the (ARKKAAKA)(n) tandem repeat peptides by cyclization or by inclusion of hydrophobic tails or cysteines to promote multimerization. These peptides exhibit high-affinity binding to LMWH (dissociation constant [K(d)], approximately 50 nM), similar potencies in neutralizing anti-Factor Xa activity of UFH and enoxaparin added to normal plasma in vitro, and efficacy equivalent to or greater than protamine. Peptide (ARKKAAKA)(3)VLVLVLVL was most effective in all plasmas from enoxaparin-treated patients, and was 4- to 20-fold more effective than protamine. Several other peptide structures were effective in some patients' plasmas. All high-affinity peptides reversed inhibition of thrombin-induced clot formation by UFH. These peptides (1 mg/300 g rat) neutralized 1 U/mL anti-Factor Xa activity of enoxaparin in rats within 1 to 2 minutes. Direct blood pressure and heart rate measurements showed little or no hemodynamic effect. These heparin-binding peptides, singly or in combination, are potential candidates for clinical reversal of UFH and LMWH in humans.
<i>Radiometry and the Detection of Optical Radiation</i> (1984)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Robert W. Boyd, Robert C. Hilborn; Radiometry and the Detection of Optical Radiation. Am. J. Phys. 1 July 1984; 52 (7): 668–669. https://doi.org/10.1119/1.13578 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAmerican Association of Physics TeachersAmerican Journal of Physics Search Advanced Search |Citation Search
The Volk steady mount holder for the +90D lens. (1988)

Since its introduction in early 1985, the Volk +90D lens has become a very popular auxiliary lens for biomicroscopic fundus evaluation. The Volk +90D lens provides a wide field of view which is accessible by simple scanning of the biomicroscope. The necessity to hand hold the lens, however, has not always provided enough stability, particularly for the novice user. This article describes a newly introduced holder for the Volk +90D lens which mounts on the base of the biomicroscope headrest providing rapid and stable lens placement. Use of this holder improves the technique of retinal examination and photography by stabilizing the image and by freeing both hands to operate the slit lamp biomicroscope. The enhanced stability afforded by this holder also gives the examiner the practical capability of viewing the posterior pole without mydriasis.
Analysis of ordered categorical data to develop control charts for monitoring customer loyalty (2009)

Abstract In the highly competitive business environment of today, the cost to attract new customers is much higher than the cost required to maintain the existing ones. To keep the balance between the acquisition rate and defection rate through executing offensive and defensive marketing policies, it is required to have real time information using an efficient method to monitor customer loyalty. The relationship between customer loyalty and customer satisfaction should be kept in mind when one develops a method for loyalty monitoring. This paper presents several control charts classified in two groups based on the scale used to assess customer loyalty. In the first group of control charts, customer loyalty is considered as a binary random variable modeled by Bernoulli distribution whilst in the second group, an ordinal scale is considered to report loyalty level. Performance comparison of the proposed techniques using ARL criterion indicates that chi‐square and likelihood‐ratio control charts developed based on Pearson chi‐square statistic and ordinal logistic regression model respectively are able to rapidly detect the significant changes in loyalty behavior. To show how to apply the procedures and how to interpret their results, two illustrative synthetic cases are also explained. Copyright © 2009 John Wiley & Sons, Ltd.
118.5 Tbit/s transmission over 316 km-long multi-core fiber with standard cladding diameter (2017)

A world record capacity 118.5 Tbit/s transmission through optical fiber with a 125 micron cladding diameter was achieved using a low loss and 316 km-long full space division multiplexing link incorporating multiple vendor technologies.
The IWAR Range: A Laboratory for Undergraduate Information Assurance Education (2000)

This paper describes a unique resource at West Point, the Information Analysis and Research Laboratory, referred to as the IWAR range. The IWAR range is an isolated laboratory used by undergraduate students and faculty researchers. The IWAR is a production-system-like, heterogeneous environment. The IWAR has become a vital part of the Information Assurance curriculum at West Point. We use the military range analogy to teach the students in the class that the exploits and other tools used in the laboratory are weapons and should be treated with the same care as rifles and grenades. This paper describes the structure of the laboratory and how it is used in classroom instruction. It also describes the process used to create the IWAR and how an IWAR might be built using limited resources. Finally, this paper describes the future directions of the IWAR project.
Determination of the<i>cis</i>sequence involved in catabolite repression of the<i>Bacillus subtilis gnt</i>operon; implication of a consensus sequence in catabolite repression in the genus<i>Bacillus</i> (1990)

The mechanism underlying catabolite repression in Bacillus species remains unsolved. The gluconate (gnt) operon of Bacillus subtilis is one of the catabolic operons which is under catabolite repression. To identify the cis sequence involved in catabolite repression of the gnt operon, we performed deletion analysis of a DNA fragment carrying the gnt promoter and the gntR gene, which had been cloned into the promoter probe vector, pWP19. Deletion of the region upstream of the gnt promoter did not affect catabolite repression. Further deletion analysis of the gnt promoter and gntR coding region was carried out after restoration of promoter activity through the insertion of internal constitutive promoters of the gnt operon before the gntR gene (P2 and P3). These deletions revealed that the cis sequence involved in catabolite repression of the gnt operon is located between nucleotide positions +137 and +148. This DNA segment contains a sequence, ATTGAAAG, which may be implicated as a consensus sequence involved in catabolite repression in the genus Bacillus.
High-frequency parallel resonant converter for X-ray generator utilizing parasitic circuit constants of high voltage-transformer and -cables (2003)

The authors describe a resonant PWM (pulse-width-modulated) inverter-linked DC-DC converter which uses the high-voltage transformer parasitic LC circuit parameters as resonant components and the high-voltage cable input capacitance as smoothing filter. Theoretical results obtained by computer-aided simulation and experimental results obtained by a test circuit including prototype transformers are illustrated and discussed from a practical point of view. The phase-shift PWM control for adjusting the DC output voltage of the resonant converter is presented. One of the advantages of this converter is minimization of circuit components; this kind of circuit topology can minimize the size and weight of power supply systems and can be applied to the filament heating circuit connected to the cathode of the X-ray tube.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Distribution and patterns of staining of Neu oncogene product in benign and malignant breast diseases. (1990)

Amplification of the Neu oncogene (c-erbB-2) has been reported by various researchers as a marker for poor clinical outcome in patients with breast cancer. We have performed immunohistochemical staining using a polyclonal antibody to the Neu oncoprotein on formalin-fixed material from normal breast, benign breast lesions, and 102 stage I node-negative breast cancers. Hybridization studies were also performed on 66 of the breast cancer cases. In the cancers 33% of cases showed positive staining of the in situ and invasive component, whereas only 25% of cases showed amplification of the Neu oncogene. The staining pattern in the tumor cells was cytoplasmic with plasma membrane accentuation. Focal positive cytoplasmic staining was noted in some cases of fibrocystic disease, fibroadenoma, and normal breast duct epithelium. Myoepithelial cells and smooth muscle of blood vessels also showed a positive reaction. This study shows that the Neu oncoprotein can be demonstrated on formalin-fixed material from normal, benign, and malignant breast lesions. In the breast cancers the differences in the number of cases showing amplification and those showing a positive immunohistochemical reaction could be due to increased transcriptional activity. It is possible that the node-negative patients whose tumors express the Neu oncogene may correspond to the group of patients who are expected to have a poor prognosis.
DNA Polymerase and Topoisomerase II Inhibitors from <i>Psoralea </i><i>c</i><i>orylifolia</i> (2003)

ADVERTISEMENT RETURN TO ISSUEPREVErratumNEXTDNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifoliaNan Jun Sun, Sung Ho Woo, John M. Cassady, and Robert M. SnapkaCite this: J. Nat. Prod. 2003, 66, 5, 734Publication Date (Web):April 15, 2003Publication History Published online15 April 2003Published inissue 1 May 2003https://pubs.acs.org/doi/10.1021/np030135thttps://doi.org/10.1021/np030135tcorrectionACS PublicationsCopyright © 2003 American Chemical Society and American Society of Pharmacognosy. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views422Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (11 KB) Get e-Alertsclose Get e-Alerts
Statistical Design of Experiments for Screening and Optimization (2019)

Abstract Design of experiments (DoE) is a family of methods for performing experiments that are maximally informative for a chosen mathematical model. Statistical design of experiments focuses on empirical models that are sufficiently flexible as to describe a wide variety of systems, while having favorable mathematical properties for convenient estimation and optimization. This review describes approaches in statistical DoE for screening through many potential influencing factors and finding optimum process conditions.
Regulation of <i>RAD53</i> by the <i>ATM</i> -Like Kinases <i>MEC1</i> and <i>TEL1</i> in Yeast Cell Cycle Checkpoint Pathways (1996)

Mutants of the Saccharomyces cerevisiae ataxia telangiectasia mutated ( ATM ) homolog MEC1/SAD3/ESR1 were identified that could live only if the RAD53/SAD1 checkpoint kinase was overproduced. MEC1 and a structurally related gene, TEL1 , have overlapping functions in response to DNA damage and replication blocks that in mutants can be provided by overproduction of RAD53 . Both MEC1 and TEL1 were found to control phosphorylation of Rad53p in response to DNA damage. These results indicate that RAD53 is a signal transducer in the DNA damage and replication checkpoint pathways and functions downstream of two members of the ATM lipid kinase family. Because several members of this pathway are conserved among eukaryotes, it is likely that a RAD53 -related kinase will function downstream of the human ATM gene product and play an important role in the mammalian response to DNA damage.
Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management. (2003)

Hybrid PET/CT improves the diagnostic interpretation of (18)F-FDG PET and CT in cancer patients and has an impact on both diagnostic and therapeutic aspects of patient management.
Southern Ocean acidification: A tipping point at 450-ppm atmospheric CO <sub>2</sub> (2008)

Southern Ocean acidification via anthropogenic CO(2) uptake is expected to be detrimental to multiple calcifying plankton species by lowering the concentration of carbonate ion (CO(3)(2-)) to levels where calcium carbonate (both aragonite and calcite) shells begin to dissolve. Natural seasonal variations in carbonate ion concentrations could either hasten or dampen the future onset of this undersaturation of calcium carbonate. We present a large-scale Southern Ocean observational analysis that examines the seasonal magnitude and variability of CO(3)(2-) and pH. Our analysis shows an intense wintertime minimum in CO(3)(2-) south of the Antarctic Polar Front and when combined with anthropogenic CO(2) uptake is likely to induce aragonite undersaturation when atmospheric CO(2) levels reach approximately 450 ppm. Under the IPCC IS92a scenario, Southern Ocean wintertime aragonite undersaturation is projected to occur by the year 2030 and no later than 2038. Some prominent calcifying plankton, in particular the Pteropod species Limacina helicina, have important veliger larval development during winter and will have to experience detrimental carbonate conditions much earlier than previously thought, with possible deleterious flow-on impacts for the wider Southern Ocean marine ecosystem. Our results highlight the critical importance of understanding seasonal carbon dynamics within all calcifying marine ecosystems such as continental shelves and coral reefs, because natural variability may potentially hasten the onset of future ocean acidification.
Micromachined accelerometer based on convection heat transfer (2002)

A micromachined thermal accelerometer that is simple, reliable, and inexpensive to make has been developed at Simon Fraser University. The operating principle of this accelerometer is based on the free-convection heat transfer of a small hot air bubble in a sealed chamber. An experimental device that requires only four masking steps to fabricate has been built. This device has demonstrated a 0.6 milli-g sensitivity that can theoretically be extended to sub-micro-g level: A 2-axis accelerometer based on the same operating principle has also been fabricated and tested.
Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes. (1988)

We have cloned the cDNA encoding a new isozyme of glycogen phosphorylase (1,4-D-glucan:orthosphosphate D-glucosyltransferase, EC 2.4.1.1) from a cDNA library prepared from a human brain astrocytoma cell line. Blot-hybridization analysis reveals that this message is preferentially expressed in human brain, but is also found at a low level in human fetal liver and adult liver and muscle tissues. Although previous studies have suggested that the major isozyme of phosphorylase found in all fetal tissues is the brain type, our data show that the predominant mRNA in fetal liver (24-week gestation) is the adult liver form. The protein sequence deduced from the nucleotide sequence of the brain phosphorylase cDNA is 862 amino acids long compared with 846 and 841 amino acids for the liver and muscle isozymes, respectively; the greater length of brain phosphorylase is entirely due to an extension at the far C-terminal portion of the protein. The muscle and brain isozymes share greater identity with regard to nucleotide and deduced amino acid sequences, codon usage, and nucleotide composition than either do with the liver sequence, suggesting a closer evolutionary relationship between them. Spot blot hybridization of the brain phosphorylase cDNA to laser-sorted human chromosome fractions, and Southern blot analysis of hamster/human hybrid cell line DNA reveals that the exact homolog of the newly cloned cDNA maps to chromosome 20, but that a slightly less homologous gene is found on chromosome 10 as well. The liver and muscle genes have previously been localized to chromosomes 14 and 11, respectively. This suggests that the phosphorylase genes evolved by duplication and translocation of a common ancestral gene, leading to divergence of elements controlling gene expression and of structural features of the phosphorylase proteins that confer tissue-specific functional properties.
System Performance Evaluation of Para Virtualization, Container Virtualization, and Full Virtualization Using Xen, OpenVZ, and XenServer (2014)

When we consider virtualization, most of the times we get confused with virtualization technique that has to be used. That is which virtualization technology gives virtual machines with better system performance. The idea of this paper is to compare and evaluate the system performance of three basic hypervisors with one supporting Para virtualization other supporting Container virtualization and the last one supporting Full virtualization. Here we chose Xen-PV for Para Virtualization, OpenVZ for Container Virtualization and XenServer for Full virtualization. Then, performance of these three virtualization techniques is evaluated based on various tests conducted by the benchmarking tools. Finally a detailed comparison among these three hypervisors will be conducted to find out the hypervisor with which virtualization technique has better system performance.
Fabrication and characterization of multi-scale microlens arrays with anti-reflection and diffusion properties (2011)

In this paper, an effective method for fabricating artificial compound-eye structures is demonstrated. The fabrication of high fill factor microlens arrays (MLAs) with sub-wavelength structures (SWSs) on a polycarbonate (PC) substrate involves nanoimprint and thermo-extrusion techniques by using two different scales of nano/micromolds. In addition, the MLAs with SWSs on the PC substrate would be replicated on a polymethylmethacrylate (PMMA) millimeter concave surface by hot-embossing, forming three-level compound-eye structures. The optical properties of these samples are characterized. The transmittances of two-level PC and three-level PMMA compound structures are increased by 2.5% and 2%, and the uniformities are enhanced by 18% and 24%, respectively.
Emergence of a<i>dhfr</i>Mutation Conferring High‐Level Drug Resistance in<i>Plasmodium falciparum</i>Populations from Southwest Uganda (2008)

The S108N, C59R, and N51I mutations in the Plasmodium falciparum gene that encodes dihydrofolate reductase, dhfr, confer resistance to pyrimethamine and are common in Africa. However, the I164L mutation, which confers high-level resistance, is rarely seen. We found a 14% prevalence of the I164L mutation among a sample of 51 patients with malaria in Kabale District in southwest Uganda in 2005 and a 4% prevalence among 72 patients with malaria in the neighboring district of Rukungiri during the same year. Surveillance at 6 sites across Uganda during 2002-2004 reported a single case of infection involving an I164L mutant, also in the southwest, suggesting that this is a regional hot spot. The spatial clustering and increasing prevalence of the I164L mutation is indicative of local transmission of the mutant. Targeted surveillance is needed to confirm the extent of the spread of the I164L mutation and to monitor the impact of I164L on the efficacy of antifolates for intermittent preventive treatment of pregnant women and/or infants with falciparum malaria.
Analysis of the function of <i>Escherichia coli</i> poly(A) polymerase I in RNA metabolism (1999)

To help understand the role of polyadenylation in Escherichia coli RNA metabolism, we constructed an IPTG‐inducible pcnB [poly(A) polymerase I, PAP I] containing plasmid that permitted us to vary poly(A) levels without affecting cell growth or viability. Increased polyadenylation led to a decrease in the half‐life of total pulse‐labelled RNA along with decreased half‐lives of the rpsO , trxA , lpp and ompA transcripts. In contrast, the transcripts for rne (RNase E) and pnp (polynucleotide phosphorylase, PNPase), enzymes involved in mRNA decay, were stabilized. rnb (RNase II) and rnc (RNase III) transcript levels were unaffected in the presence of increased polyadenylation. Long‐term overproduction of PAP I led to slower growth and irreversible cell death. Differential display analysis showed that new RNA species were being polyadenylated after PAP I induction, including the mature 3′‐terminus of 23S rRNA, a site that was not tailed in wild‐type cells. Quantitative reverse transcriptase–polymerase chain reaction (RT–PCR) demonstrated an almost 20‐fold variation in the level of polyadenylation among three different transcripts and that PAP I accounted for between 94% and 98.6% of their poly(A) tails. Cloning and sequencing of cDNAs derived from lpp , 23S and 16S rRNA revealed that, during exponential growth, C and U residues were polymerized into poly(A) tails in a transcript‐dependent manner.
Open path CO<sub>2</sub>analyser (1981)

An open path CO2 analyser is described for measuring CO2 fluxes over crop canopies by the eddy correlation technique. The analyser measures CO2 concentration within 0.3 ppm by volume with a time constant of 0.075 s. The CO2 concentration is determined from a comparison of the absorption of infrared radiation in the 3.7 mu m and 4.3 mu m bands over a 1.5 m path.