gebhart/patrepeval huggingface dataset:
The Alkaloids of Tabernanthe iboga. Part IV.<sup>1</sup> The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and VoacangineM. F. Bartlett, D. F. Dickel, and W. I. TaylorCite this: J. Am. Chem. Soc. 1958, 80, 1, 126–136Publication Date (Print):January 1, 1958Publication History Published online1 May 2002Published inissue 1 January 1958https://doi.org/10.1021/ja01534a036RIGHTS & PERMISSIONSArticle Views1157Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Band structure nonlocal pseudopotential calculation of the III-nitride wurtzite phase materials system. Part I. Binary compounds GaN, AlN, and InN (2000)

This work presents nonlocal pseudopotential calculations based on realistic, effective atomic potentials of the wurtzite phase of GaN, InN, and AlN. A formulation formulation for the model effective atomic potentials has been introduced. For each of the constitutive atoms in these materials, the form of the effective potentials is optimized through an iterative scheme in which the band structures are recursively calculated and selected features are compared to experimental and/or ab initio results. The optimized forms of the effective atomic potentials are used to calculate the band structures of the binary compounds, GaN, InN, and AlN. The calculated band structures are in excellent overall agreement with the experimental/ab initio values, i.e., the energy gaps at high-symmetry points, valence-band ordering, and effective masses for electrons match to within 3%, with a few values within 5%. The values of the energy separation, effective masses, and nonparabolicity coefficients for several secondary valleys are tabulated as well in order to facilitate analytical Monte Carlo transport simulations.
Gold nanoparticle sensors for environmental pollutant monitoring (2007)

Gold nanoparticles (Au-NPs) have been synthesised using a sacrificial anode electrolysis in the presence of tetra-alkyl-ammonium halides, employed as cationic stabilizers. Catalytic NPs have been then deposited on top of Field Effect (FE) gas sensing devices and subjected to mild annealing procedures. Transmission Electron Microscopy (TEM) shows that the NP average core diameter is around 5 nm. X-Ray Photoelectron Spectroscopy (XPS) and Scanning Electron Microscopy (SEM) have been applied to the surface characterization of the annealed NP films used as active sensing layers. Morphological and spectroscopic results demonstrate that the annealed inorganic nano-clusters are finely dispersed and maintain a metallic oxidation state. Au-NPs can be proficiently employed as gate material in Si-Field Effect Gas Sensors. Preliminary results show interesting selectivity and sensitivity sensing features towards NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> detection.
Microfibrillar structure of type I collagen <i>in situ</i> (2006)

The fibrous collagens are ubiquitous in animals and form the structural basis of all mammalian connective tissues, including those of the heart, vasculature, skin, cornea, bones, and tendons. However, in comparison with what is known of their production, turnover and physiological structure, very little is understood regarding the three-dimensional arrangement of collagen molecules in naturally occurring fibrils. This knowledge may provide insight into key biological processes such as fibrillo-genesis and tissue remodeling and into diseases such as heart disease and cancer. Here we present a crystallographic determination of the collagen type I supermolecular structure, where the molecular conformation of each collagen segment found within the naturally occurring crystallographic unit cell has been defined (P1, a approximately 40.0 A, b approximately 27.0 A, c approximately 678 A, alpha approximately 89.2 degrees , beta approximately 94.6 degrees , gamma approximately 105.6 degrees ; reflections: 414, overlapping, 232, and nonoverlapping, 182; resolution, 5.16 A axial and 11.1 A equatorial). This structure shows that the molecular packing topology of the collagen molecule is such that packing neighbors are arranged to form a supertwisted (discontinuous) right-handed microfibril that interdigitates with neighboring microfibrils. This interdigitation establishes the crystallographic superlattice, which is formed of quasihexagonally packed collagen molecules. In addition, the molecular packing structure of collagen shown here provides information concerning the potential modes of action of two prominent molecules involved in human health and disease: decorin and the Matrix Metallo-Proteinase (MMP) collagenase.
A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting (2010)

Angiogenesis is controlled by signals that stimulate motility in endothelial cells at the tips of vascular sprouts while maintaining cell-cell adhesion in the stalks of angiogenic sprouts. We show here that Gs-linked G protein-coupled receptor activation of cAMP-dependent protein kinase (PKA) plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase, leading to inhibition of pp60Src. Activated PKA blocks pp60Src-dependent vascular endot helial-cadherin phosphorylation, thereby stimulating cell-cell adhesion while suppressing endothelial cell polarization, motility, angiogenesis, and vascular permeability. Similar to the actions of Notch and Dll4, PKA activation blocks sprouting in newly forming embryonic blood vessels, while PKA inhibition promotes excessive sprouting in these vessels. These findings demonstrate that G protein-coupled receptors and PKA regulate vascular sprouting during angiogenesis by controlling endothelial cell migration and cell-cell adhesion through their actions on pp60Src.
Modeling the anti‐CEA antibody combining site by homology and conformational search (1992)

A model for an antibody specific for the carcinoembryonic antigen (CEA) has been constructed using a method which combines the concept of canonical structures with conformational search. A conformational search technique is introduced which couples random generation of backbone loop conformations to a simulated annealing method for assigning side chain conformations. This technique was used both to verify conformations selected from the set of known canonical structures and to explore conformations available to the H3 loop in CEA ab initio. Canonical structures are not available for H3 due to its variability in length, sequence, and observed conformation in known antibody structures. Analysis of the results of conformational search resulted in three equally probable conformations for H3 loop in CEA. Force field energies, solvation free energies, exposure of charged residues and burial of hydrophobic residues, and packing of hydrophobic residues at the base of the loop were used as selection criteria. The existence of three equally plausible structures may reflect the high degree of flexibility expected for an exposed loop of this length. The nature of the combining site and features which could be important to interaction with antigen are discussed.
Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics (2011)

A total of 23 strains of bifidobacteria taxonomically belonging to five species were tested for their potent immunomodulatory effect using a combination of two methods: the NF-κB-reporter assay using a toll-like receptor 2-expressing transfectant (HEK(pTLR2) system) and the mitogenic assay using porcine Peyer's patches immunocompetent cells. Among the four preselected strains from different immunomodulatory groups, Bifidobacterium breve MCC-117 was able to efficiently modulate the inflammatory response triggered by enterotoxigenic Escherichia coli (ETEC) in a porcine intestinal epithelial (PIE) cell line. Moreover, using PIE cells and swine Peyer's patches immunocompetent cell co-culture system, we demonstrated that the immunoregulatory effect of B. breve MCC-117 was related to the capacity of the strain to influence PIE and immune cell interactions, leading to the stimulation of regulatory T cells. The results suggested that bifidobacteria that express high activity in both the HEK(pTLR2) and the mitogenic assays may behave like potential anti-inflammatory strains. The combination of the HEK(pTLR2) system, the evaluation of mitogenic activity and PIE cells will be of value for the development of new immunologically functional foods and feeds that could prevent inflammatory intestinal disorders. Although our findings should be proven in appropriate experiments in vivo, the results of the present work provide a scientific rationale for the use of B. breve MCC-117 to prevent ETEC-induced intestinal inflammation.
Decoy receptor 3 inhibits renal mononuclear leukocyte infiltration and apoptosis and prevents progression of IgA nephropathy in mice (2011)

The progression of IgA nephropathy (IgAN), the most frequent type of primary glomerulonephritis, is associated with high levels of mononuclear leukocyte infiltration into the kidney. These cells consist mainly of T cells and macrophages. Our previous study showed that a decoy receptor 3 (DCR3) gene therapy can prevent the development of a mouse autoimmune glomerulonephritis model by its potent immune modulating effects (Ka SM, Sytwu HK, Chang DM, Hsieh SL, Tsai PY, Chen A. J Am Soc Nephrol 18: 2473-2485, 2007). Here, we tested the hypothesis that DCR3 might prevent the progression of IgAN, an immune complex-mediated primary glomerulonephritis, by inhibiting T cell activation, renal T cell/macrophage infiltration, and protecting the kidney from apoptosis. We used a progressive IgAN (Prg-IgAN) model in B cell-deficient mice, because the mice are characterized by a dramatic proliferation of activated T cells systemically and progressive NF-κB activation in the kidney. We treated the animals with short-term gene therapy with DCR3 plasmids by hydrodynamics-based gene delivery. When the mice were euthanized on day 21, we found that, compared with empty vector-treated (disease control) Prg-IgAN mice, DCR3 gene therapy resulted in 1) systemic inhibition of T cell activation and proliferation; 2) lower serum levels of proinflammatory cytokines; 3) improved proteinuria, renal function, and renal pathology (inhibiting the development of marked glomerular proliferation, crescent formation, glomerulosclerosis, and interstitial inflammation); 5) suppression of T cell and macrophage infiltration into the periglomerular interstitium of the kidney; and 5) a reduction in apoptotic figures in the kidney. On the basis of these findings, DCR3 might be useful therapeutically in preventing the progression of IgAN.
Evidence of a novel staphylococcal mec-encoded element (mecR) controlling expression of penicillin-binding protein 2' (1990)

A region was identified on the methicillin resistance determinant (mec) isolated from Staphylococcus epidermidis and cloned into Staphylococcus carnosus which was responsible for a novel downregulation of the expression of methicillin resistance. The presence of this region reduced the overall expression of methicillin resistance and the synthesis of the mec-encoded penicillin-binding protein 2' (PBP 2') in S. carnosus. This region was located by Bal31 deletion mutagenesis upstream of the structural gene for PBP 2'. Deletions within this region resulted in higher levels of expression of methicillin resistance and increased levels of PBP 2' synthesis. We tentatively called this region mecR. Analysis of selected Mcr strains of Staphylococcus aureus and S. epidermidis by Southern hybridization suggested that the natural occurrence of two types of mec resistance determinants differ by the presence or absence of mecR-specific sequences.
A quality-guaranteed and energy-efficient query processing algorithm for sensor networks (2006)

Query processing methods have been studied extensively in traditional database systems. But few of them can be directly applied into sensor database systems due to the characteristics of sensor networks: decentralized nature of sensor networks, limited computational power, imperfect information recorded, and energy scarcity of individual sensor nodes. In this paper, we propose a quality-guaranteed and energy-efficient algorithm (QGEE) for sensor database systems. We employ an in-network query processing method to task sensor networks through declarative queries. Given a query, our QGEE will adaptively form an optimal query plan in terms of energy efficiency and query quality. The goal of our approach is to reduce interference coming from measurements with extreme errors and to minimize energy consumption by providing service that is considerably necessary and sufficient for the requirement of applications. Moreover, we employ probabilistic method to formulate the distribution of imperfect information sources in terms of probability distribution function (PDF), and acquire probabilistic query answers on uncertain data. The probability to an answer allows users to place appropriate confidence in it. Simulation results demonstrate that our algorithm can reduce resource usage and supply quality satisfied query answers to users
The Charisma of Subgroups and the Subgroups of CHARISMA (2006)

Antiplatelet therapy with aspirin, an irreversible inhibitor of platelet cyclooxygenase, has earned its rightful place as a cornerstone of treatment for reducing cardiovascular events in patients with established vascular disease.1,2 This statement is based on consistent results favoring aspirin in a large number of randomized, controlled trials in populations with either acute or long-term disease. Clopidogrel, by inhibiting the adenosine diphosphate P2Y12 receptor, offers a distinctly different mechanism to reduce platelet activation and aggregation. As monotherapy, clopidogrel has been shown to be effective in reducing the risk of vascular events in patients with established vascular disease.3 Even more . . .
Femtosecond all-optical switching in AlGaAs waveguides using a time division interferometer (1989)

All-optical switching of femtosecond pulses in AlGaAs waveguides is investigated using a novel time division interferometric technique which eliminates thermal imbalances. In addition to an instantaneous refractive index nonlinearity, free-carrier generation via two-photon absorption produces a response of several hundred picoseconds duration.
The nasal cavity microbiota of healthy adults (2014)

There are clear differences between nasal cavity microbiota and oral cavity microbiota in healthy adults. This study expands our knowledge of the nasal cavity microbiota and the relationship between the microbiota of the nasal and oral cavities.
Wiar: A Public Dataset for Wifi-Based Activity Recognition (2019)

We construct a public dataset for WiFi-based Activity Recognition named WiAR with sixteen activities operated by ten volunteers in three indoor environments. It aims to provide public signal data for researchers to reduce the cost of collected signal data and conveniently evaluate the performance of WiFi-based human activity recognition in different domains. First, we introduce the basic knowledge of WiFi signals regarding RSSI, CSI, and wireless hardware. Second, we explain the characteristics of WiAR dataset in terms of activities types, data format, data acquisition ways, and influence factors. Third, the proposed framework can estimate the quality of the shared signal data provided by other peers. Finally, we select and use five classification algorithms and two deep learning algorithms to evaluate the performance of WiAR dataset on human activity recognition. The results show that the accuracy of WiAR dataset is higher than 80% using machine learning algorithms and 90% using deep learning algorithms in different indoor environments.
A novel utility interfaced high-frequency link photovoltaic power conditioning system (1988)

Utility-line-interfaced photovoltaic power conditioning (PVPC) systems are gaining popularity in augmenting energy. PVPC systems utilizing a high-frequency (HF) isolation link have the well-known advantages of small size, light weight, etc. Here, a utility interfaced HF-link PVPC system is presented. The system discussed consists of a resonant (load commutated asymmetrical silicon-controlled rectifier) (ASCR) HF inverter, a rectifier, and a line-commutated inverter working with a power factor near unity. An HF transformer provides the isolation between the photovoltaic array and the utility line. The HF resonant inverter uses an LCC type commutation circuit and has inherent fault-protection capability under a number of fault conditions. The working details of the scheme are presented together with logic circuit schematics. Experimental results obtained with a prototype unit are also given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor. A novel strategy for the therapy of KS. (1994)

Kaposi's sarcoma (KS) is the most frequent tumor of HIV-1-infected individuals (AIDS-KS). Typical features of KS are proliferating spindle-shaped cells, considered to be the tumor cells of KS, and endothelial cells forming blood vessels. Basic fibroblast growth factor (bFGF), a potent angiogenic factor, is highly expressed by KS spindle cells in vivo and after injection in nude mice it induces vascular lesions closely resembling early KS in humans. Similar lesions are induced by inoculating nude mice with cultured spindle cells from AIDS-KS lesions (AIDS-KS cells) which produce and release bFGF. Here we show that phosphorothioate antisense (AS) oligonucleotides directed against bFGF mRNA (ASbFGF) inhibit both the growth of AIDS-KS cells derived from different patients and the angiogenic activity associated with these cells, including the induction of KS-like lesions in nude mice. These effects are due to the block of the production of bFGF which is required by AIDS-KS cells to enter the cell cycle and which, after release, mediates angiogenesis. The effects of ASbFGF are specific, dose dependent, achieved at low (0.1-1 microM), nontoxic, oligomer concentrations, and are reversed by the addition of bFGF to the cells, suggesting that ASbFGF oligomers are promising drug candidates for KS therapy.
Role of methylation in the modification and restriction of chloroplast DNA in Chlamydomonas. (1979)

The different metabolic paths followed by homologous chloroplast DNAs of maternal and paternal origins in zygotes of Chlamydomonas were examined by prelabeling parental cells, before mating them, with [3H]adenine, [3H]thymidine, and [3H]deoxycytidine. Within 6 hr after mating, maternal chloroplast DNA was extensively methylated to 5-methylcytosine and its bouyant density decreased. Paternal chloroplast DNA was largely degraded. Some radioactivity from deoxycytidine of maternal origin reappeared in thymine, and residual paternal DNA contained radioactivity in a base tentatively identified as uracil. These results confirm and extend our previous findings and support our hypothesis that modification (methylation) and restriction enzymes determine maternal inheritance of chloroplast DNA and that the two parental DNAs have different metabolic fates within the zygote.
The plant hormone indoleacetic acid induces invasive growth in <i>Saccharomyces cerevisiae</i> (2004)

Fungi must recognize plant-specific signals to initiate subsequent morphogenetic events such as filamentation that lead to infection. Here we show that the plant hormone indoleacetic acid (IAA) induces adhesion and filamentation of Saccharomyces cerevisiae . Genome expression profiling of cells treated with IAA identified Yap1, a fungal specific transcription factor, as a key mediator of this response. Strains lacking YAP1 ( yap1-1 ) are hypersensitive to growth on IAA because they accumulate more IAA than can wild type. Members of a family of transporters the amino acid/auxin:proton symport permeases with homology to AUX1 , a putative IAA transporter from plants, are up-regulated in the yap1-1 mutant. Deletion of any one of these transporters makes yap1-1 mutants more resistant to IAA by decreasing its uptake. The permease mutants are defective in IAA perception and filamentation. The ability of a fungus to perceive a plant hormone that causes it to differentiate into an invasive form has important implications for plant–pathogen interactions.
Enterochromaffin-Like Cell Carcinoids in the Rat Gastric Mucosa following Long-Term Administration of Ranitidine (1990)

Long-term administration of some long-acting inhibitors of gastric acid secretion has been associated with the development of gastric enterochromaffin-like (ECL)-cell carcinoids in the rat. It has been argued that short-acting, surmountable histamine H2receptor blockers such as ranitidine do not cause carcinoids. In this study, female rats (n = 100) were treated for 2 years with the histamine H2-receptor blocker ranitidine, 2 g/kg/day in the diet. Specimens from the stomachs of all rats, including 50 controls, were stained for argyrophil cells. Plasma gastrin and ranitidine levels were measured in separate groups of rats at different times during the study. The mean plasma level of ranitidine was 37.5 μmol/l, measured at midnight when the maximal level after food intake was expected. The resulting acid inhibition was associated with an approximately 3-fold increase in plasma gastrin which persisted throughout the whole period of the study. The ranitidine treatment resulted in a pronounced hyperplasia of gastric ECL cells. In 19 rats carcinoids were found, 4 of which were micro-invasive. No carcinoids were found in the control animals. The results provide further support for the gastrin mechanism, i.e. that the development of ECL-cell carcinoids in the rat gastric mucosa is a consequence of prolonged hypergastrinaemia and is not a unique effect of any individual acid-inhibiting drug.