gebhart/patrepeval huggingface dataset:
A trajectory prediction based intelligent handover control method in UAV cellular networks (2019)

The airborne base station (ABS) can provide wireless coverage to the ground in unmanned aerial vehicle (UAV) cellular networks. When mobile users move among adjacent ABSs, the measurement information reported by a single mobile user is used to trigger the handover mechanism. This handover mechanism lacks the consideration of movement state of mobile users and the location relationship between mobile users, which may lead to handover misjudgments and even communication interrupts. In this paper, we propose an intelligent handover control method in UAV cellular networks. Firstly, we introduce a deep learning model to predict the user trajectories. This prediction model learns the movement behavior of mobile users from the measurement information and analyzes the positional relations between mobile users such as avoiding collision and accommodating fellow pedestrians. Secondly, we propose a handover decision method, which can calculate the users' corresponding receiving power based on the predicted location and the characteristic of air-to-ground channel, to make handover decisions accurately. Finally, we use realistic data sets with thousands of non-linear trajectories to verify the basic functions and performance of our proposed intelligent handover control method. The simulation results show that the handover success rate of the proposed method is 8% higher than existing methods.
Spinal mechanisms of acute and persistent pain (1999)

Although there is considerable information about the mechanisms through which injury stimuli produce acute pain, recent studies indicate that there are significant long-term consequences of persistent injury. Pain is exacerbated, in part, because of a reorganization of spinal cord circuitry in the setting of persistent injury. This review describes our studies of the contribution of the primary afferent neurotransmitter, substance P (SP), to these changes. By following internalization of the SP receptor in spinal cord dorsal horn neurons, we have identified the stimuli that evoke SP release and the neurons that respond to these stimuli. Importantly, based on the intensities of stimuli required to evoke internalization, we conclude that SP is only released under conditions in which severe pain would be produced, that the release can be evoked by intense stimulation of somatic and visceral tissue, and that multiple stimulus modalities are effective. We also found that the numbers of neurons that are influenced increases dramatically in the setting of inflammation. Using a knockout strategy, we have also raised mice with a deletion of the preprotachykinin-A (PPT-A) gene, which encodes for SP and neurokinin A (NKA), and have identified a specific behavioral phenotype in which the animals do not detect a window of "pain" intensities; this window cuts across stimulus modalities. These results provide an important behavioral correlate of the receptor internalization studies. On the other hand, the allodynia (lowered pain threshold) that occurs in the setting of injury was not altered in these animals. Among the factors that could underlie injury-induced allodynia are the second messenger systems that are activated in dorsal horn neurons. Our studies have recently implicated the gamma isoform of protein kinase C (PKCgamma) in the development of nerve injury-induced neuropathic pain. Specifically, we found that although acute pain responses of mice with a deletion of PKCgamma are not altered, partial injury to the sciatic nerve (which induces a severe thermal and mechanical allodynia in the wild type mouse) is without effect in the knockout. Furthermore, the anatomical/neurochemical reorganization that typically follows sciatic nerve section does not occur in the PKCgamma mutant mice. Because the spinal cord distribution of interneurons that express PKCgamma is concentrated almost exclusively in the inner part of lamina II, we believe that changes in the properties of these neurons are key to the development of nerve injury-induced neuropathic pain conditions. Taken together, these studies emphasize that persistent pain should be considered a disease state of the nervous system, not merely a symptom of some other disease conditions. In the setting of persistent injury, the nervous system undergoes dramatic changes that exacerbate and prolong the pain condition. Our studies underscore the importance of preventing the long-term changes that result from persistent injury.
Brain-inspired computing with spin torque devices (2014)

In this paper we discuss the potential of emerging spin-torque devices for computing applications. Recent proposals for spin-based computing schemes may be differentiated as `all-spin' vs. hybrid, programmable vs. fixed, and, Boolean vs. non-Boolean. Allspin logic-styles may offer high area-density due to small form-factor of nano-magnetic devices. However, circuit and system-level design techniques need to be explored that leaverage the specific spin-device characterisitcs to achieve energy-efficiency, performance and reliability comparable to those of CMOS. The non-volatility of nano-magnets can be exploited in the design of energy and area-efficient programmable logic. In such logic-styles, spin-devices may play the dual-role of computing as well as memory-elements that provide field-programmability. Spin-based threshold logic design is presented as an example. Emerging spintronic phenomena may lead to ultra-low-voltage, current-mode, spin-torque switches that can offer attractive computing capabilities, beyond digital switches. Such devices may be suitable for non-Boolean data-processing applications which involve analog processing. Integration of such spin-torque devices with charge-based devices like CMOS and resistive memory can lead to highly energy-efficient information processing hardware for applicatons like pattern-matching, neuromorphic-computing, image-processing and data-conversion. Finally, we discuss the possibility of using coupled spin-torque nano oscillators for low-power non-Boolean computing.
<title>Simple and reusable fiber-to-chip interconnect with adjustable coupling efficiency</title> (1997)

A simple, efficient and reusable fiber-to-chip interconnect is presented. The interconnect is based on a V-groove (wet- chemically etched) in silicon, combined with a loose-mode Si<SUB>3</SUB>N<SUB>4</SUB>-channel waveguide. The loose-mode waveguide is adiabatically tapered to the integrated optical (sensor) circuitry. This adiabatic taper enables the dimensions of both the integrated optical sensor circuitry and the loose- mode waveguide section to be designed independently. The coupling efficiency of the `plug-it-in' interconnect is tunable between zero and the maximum obtainable value by tightening two adjustment screws. Coupling efficiencies up to 60% using TE-polarized light at wavelength of 632.8 nm have been reproducibly measured.
Neural network detection and decoding of PSK signals (2008)

The neural network method of detection for PSK signals is presented. The constructed system allows to carry out detection and decoding of QPSK signals simultaneously. Processing of test signals by the proposed method shows its ability for work.
Early Glasgow Outcome Scale Scores Predict Long-Term Functional Outcome in Patients with Severe Traumatic Brain Injury (2005)

Patients sustaining severe traumatic brain injury (TBI) have variable long-term outcomes. We examined the association between Glasgow Outcome Scale (GOS) assessed at 3 months and long-term outcomes at 12 months after TBI. We studied 159 patients with severe, closed traumatic brain injuries (Glasgow Coma Scale [GCS] <or= 8) who were treated at an academic medical center and survived for a minimum of 3 months after TBI. Demographics and admission clinical data and GOS at 3 and 12 months were analyzed. Multivariate logistic regression was used to asses the relationship between 3-month GOS, demographics, and clinical data and a poor outcome, defined as GOS 1-3 assessed at 12 months after injury. The patient population was predominantly male (77%), with a median age of 30 years and a median admission GCS of 6. The logistic regression model showed that the GOS at 3 months was the best predictor of 12-month outcomes (odds ratio = 15.22, p < 0.001). The presence of prolonged hypotension, diffuse axonal injury (DAI), and fixed and dilated pupils on admission were also significant independent predictors of poor 12-month outcome (for all, p <or= 0.047). The adjusted logistic model showed a steep gradient of long-term recovery potential depending upon GOS at 3 months, ranging from an 89.4% chance of poor outcome for patients with a GOS of 2, to a 0.11% chance of poor outcome for those with a GOS of 5. The 3-month GOS is a powerful independent predictor of long-term outcome for patients with severe TBI. Prolonged hypotension, DAI, and the presence of fixed and dilated pupils were also independent predictors of poor outcome.
Mode of action of pediocin AcH from <i>Pediococcus acidilactici</i> H on sensitive bacterial strains (1991)

The peptide, pediocin AcH, from Pediococcus acidilactici H binds to the cell surface of Lactobacillus plantarum NCDO 955, its resistant mutant and several other sensitive and resistant Gram‐positive bacteria but not to Gram‐negative bacteria. Sensitive cells, following treatment with pediocin AcH, lost intracellular K ions, u.v.‐absorbing materials, became more permeable to ONPG and, in some strains, lysed. Binding of pediocin AcH was maximum at pH 6.0. Anions of several salts inhibited binding of pediocin AcH but this was overcome by increased concentrations of pediocin AcH. Treatment of sensitive cells with 1% SDS, 4 mol/1 guanidine‐HCl, several organic solvents and enzymes did not reduce subsequent binding of pediocin AcH. Partially purified cell wall from a sensitive strain was also able to bind pediocin AcH. However, treatment of the cell walls to remove lipoteichoic acid prevented binding. These molecules might, therefore, be one of the binding sites of pediocin AcH.
How I treat first relapse of myeloma (2017)

The standard treatment of relapsed multiple myeloma has been either lenalidomide-dexamethasone (RD) or bortezomib-dexamethasone (VD) but it is changing rapidly for 2 reasons. First, lenalidomide and bortezomib are currently used in frontline treatment and many patients become resistant to these agents early in the course of their disease. Second, 6 second-line new agents have been recently developed and offer new possibilities (pomalidomide, carfilzomib and ixazomib, panobinostat, elotuzumab, and daratumumab). Recent randomized studies have shown that triple combinations adding 1 of these new agents (except pomalidomide) to the RD or VD regimens were superior to the double combinations in terms of response rate and progression-free survival (PFS). Their place in the treatment of first relapse is discussed here. Among these agents, daratumumab is clearly a breakthrough and daratumumab-based combinations might become the preferred option in the near future. However, all of these drugs are expensive and are not available or affordable in all countries. We propose a decision algorithm for first relapse in fit patients with the objective of achieving the best PFS. The choice of salvage regimen is based on lenalidomide/bortezomib resistance, daratumumab availability, and cost. Autologous transplantation should be considered in younger patients if not used upfront.
Current evidence for histone deacetylase inhibitors in pancreatic cancer (2013)

Pancreatic cancer is one of the most aggressive human cancers, with more than 200 000 deaths worldwide every year. Despite recent efforts, conventional treatment approaches, such as surgery and classic chemotherapy, have only slightly improved patient outcomes. More effective and well-tolerated therapies are required to reverse the current poor prognosis of this type of neoplasm. Among new agents, histone deacetylase inhibitors (HDACIs) are now being tested. HDACIs have multiple biological effects related to acetylation of histones and many non-histone proteins that are involved in regulation of gene expression, apoptosis, cell cycle progression and angiogenesis. HDACIs induce cell cycle arrest and can activate the extrinsic and intrinsic pathways of apoptosis in different cancer cell lines. In the present review, the main mechanisms by which HDACIs act in pancreatic cancer cells in vitro, as well as their antiproliferative effects in animal models are presented. HDACIs constitute a promising treatment for pancreatic cancer with encouraging anti-tumor effects, at well-tolerated doses.
Performance analysis of isolated ZVT interleaved converter with winding-cross-coupled inductors and switched-capacitors (2010)

In this paper, a third winding and an additional switched capacitor are inserted into each phase of the conventional interleaved Flyback converter to derive a novel triple boost converter for high step-up conversion. Furthermore, the active clamp circuit, which is composed of a power MOSFET and a small capacitor, is inserted to the primary side of each phase to recycle the leakage energy and to suppress the switch turn-off voltage spikes. Moreover, ZVT soft switching performance is achieved to reduce the switching losses for all the primary power switches during the whole switching transition. In addition, the leakage energy is recycled and the secondary side diode reverse-recovery problem is alleviated. Finally, a 500W 24V-380V prototype is built and tested to verify the effectiveness of the proposed solution.
PalletPicker‐3D, the solution for picking of randomly placed parts (2003)

It is now possible to pick randomly placed parts from a bin automatically. SVIA have developed a patented bin‐picking system that is general and easy for the operator to teach. It is possible because of the combination of a high precision optical 3D‐measuring technique, modern image processing and six‐axis robot technology.
Electromagnetic mode density for finite quasi-periodic structures (1998)

The transmission properties of quasi-periodic Cantor-like and Fibonacci photonic bandgap structures that have the same optical paths are studied and compared with one-dimensional, finite, N-period stacks. The electromagnetic mode densities and group velocities are also discussed. We show that the density of modes at the edge of the bandgap is greater for Cantor-like multilayers, so at the band edge a sharp decrease in the group velocity is found.
Hierarchical Techniques for Visibility Computations (2002)

The thesis proposes a taxonomy of visibility (vis.) problems based on the dimension of the problem-relevant line set, i.e. set of lines forming the domain of the vis. problem. The taxonomy helps to identify relationships between vis. problems from various application areas by grouping together problems of similar complexity. The thesis presents a general concept of a vis. algorithm (alg.) suitable for solution of several classes of vis. problems. The concept is based on 3 main ideas: an approximate occlusion sweep, an occlusion tree and hierarchical vis. tests. The central idea of the concept is the occlusion tree representing an aggregated occlusion map by means of a hierarchical subdivision in line space. The thesis presents several applications of the concept. The major focus is placed on vis. culling alg. for real-time rendering acceleration. We describe an alg. for real-time vis. culling. The alg. is used to accelerate rendering of large densely occluded scenes. It improves previous results by efficiently performing occluder fusion in real-time. We propose several techniques exploiting temporal and spatial coherence applicable to most existing hierarchical vis. culling methods and an alg. for computing vis. maps in polygonal scenes. The alg. provides a comprehensive description of the topology of the given view of the scene. We discuss an application of the alg. to discontinuity meshing. The proposed concept is applied to comput. of from-region vis. in 2D scenes. We present and evaluate an exact analytic alg. for comput. a potentially visible set for a polygonal region in the plane. We propose 2 alg. for comput. from-region vis. in 21/2D scenes. Both alg. are targeted at vis. preprocessing for walkthroughs of outdoor urban scenes. The methods are compared with another recent technique. We describe an exact analytic alg. for comput. from-region vis. in 3D scenes suitable for various applications. The alg. uses Plucker coordinates and maintains a hierarchical subdivision of 5D space. We discuss its application to vis. preprocessing, occluder synthesis and discontinuity meshing.
Simple rail-to-rail low-voltage constant-transconductance CMOS input stage in weak inversion (1993)

A CMOS input stage for operational amplifiers is presented. To obtain a rail-to-rail input range an nMOS and a pMOS differential pair are driven in parallel. Both differential pairs operate in weak inversion. With the help of only four additional transistors a transconductance gm is obtained which is independent of the common input voltage. This extension does not increase the minimum required supply voltage.
Selective Diethylzinc Reduction of Imines in the Presence of Ketones Catalyzed by Ni(acac)<sub>2</sub> (2005)

A selective reduction method of an electronically deficient imine in the presence of ketone was developed by employing Et(2)Zn and 5 mol % of Ni(acac)(2). The method was applied in the reduction of S(S)-tert-butanesulfinyl ketimines 1 to afford amines 2 in 23-92% yields and 73:27 to 98:2 diastereoselectivities. A plausible mechanism was proposed on the basis of an NMR study.
Quantitative Proteomic Analysis of Post-translational Modifications of Human Histones (2006)

Histone proteins are subject to a range of post-transcriptional modifications in living cells. The combinatorial nature of these modifications constitutes the "histone code" that dictates chromatin structure and function during development, growth, differentiation, and homeostasis of cells. Deciphering of the histone code is hampered by the lack of analytical methods for monitoring the combinatorial complexity of reversible multisite modifications of histones, including acetylation and methylation. To address this problem, we used LC-MSMS technology and Virtual Expert Mass Spectrometrist software for qualitative and quantitative proteomic analysis of histones extracted from human small cell lung cancer cells. A total of 32 acetylations, methylations, and ubiquitinations were located in the human histones H2A, H2B, H3, and H4, including seven novel modifications. An LC-MSMS-based method was applied in a quantitative proteomic study of the dose-response effect of the histone deacetylase inhibitor (HDACi) PXD101 on histone acetylation in human cell cultures. Triplicate LC-MSMS runs at six different HDACi concentrations demonstrated that PXD101 affects acetylation of histones H2A, H2B, H3, and H4 in a site-specific and dose-dependent manner. This unbiased analysis revealed that a relative increase in acetylated peptide from the histone variants H2A, H2B, and H4 was accompanied by a relative decrease of dimethylated Lys(57) from histone H2B. The dose-response results obtained by quantitative proteomics of histones from HDACi-treated cells were consistent with Western blot analysis of histone acetylation, cytotoxicity, and dose-dependent expression profiles of p21 and cyclin A2. This demonstrates that mass spectrometry-based quantitative proteomic analysis of post-translational modifications is a viable approach for functional analysis of candidate drugs, such as HDAC inhibitors.
Thickness and conductivity of metallic layers from pulsed eddy-current measurements (1996)

We describe a time-domain (pulsed) eddy-current technique for determining the thickness and conductivity of conductive coatings on metal plates. The pulsed eddy-current instrument records the transient current induced in an absolute, air-cored coil placed next to a layered sample and excited with a step-function change in voltage. Signals are digitized with 16-bit resolution at a sampling rate of 1 megasamples per second, and the excitation is repeated at a rate of 1 kHz. The instrument displays the difference in the transient current measured on the substrate and on the substrate plus coating. We measured pulsed eddy-current signals for a series of metal foils of varying thickness placed over 1 cm thick metal plates. Seven combinations of foil and substrate metals were studied including pure aluminum, copper, and titanium foils over substrates of aluminum, titanium alloy, and stainless steel. We report results for three types of samples: aluminum foils on Ti–6Al–4V substrate, titanium foils on 7075 aluminum alloys, and aluminum foils on AISI 304 stainless steel. Foil thickness ranged from 0.04–1.00 mm. We found that three features of the signal—the peak height, the time of occurrence of the first peak, and a characteristic zero-crossing time—depend sensitively upon the thickness of the layers and the relative electrical conductivity of coating and substrate. Theoretical calculations were compared to the measurements. Absolute agreement between calculated and measured signals was, in most cases, within 3%. No calibration with respect to artifact standards was used. Finally, a feature-based rapid inversion method was developed and used to infer the thickness and conductivity of the layers. The accuracy of the inversion depends upon the thickness of the layer and the contrast in conductivity between layer and substrate. For the materials studied the thickness could be determined within 13%, while the error in determining conductivity was 20%–30%. The time-domain method is much simpler and hundreds of times faster than the frequency-domain method previously reported by Moulder et al. [Rev. Sci. Instrum. 63, 3455 (1992)].
Oxygen Scavengers: An Approach on Food Preservation (2012)

Oxygen (O2) presence in food packages is mainly due to failures in the packaging process, such as mixture of gases containing oxygen residues, or inefficient vacuum. Vacuum packaging has been widely used to eliminate oxygen in the package prior to sealing. However, the oxygen that permeates from the outside environment into the package through the packaging material cannot be removed by this method (Byun et al., 2011).
Parallel vs. anti-parallel orientation in a curdlan/oligo(dA) complex as estimated by a FRET technique (2005)

We already found that beta-1,3-glucan polysaccharides form polymeric complexes with certain polynucleotides, but the parallel vs. anti-parallel orientation in those complexes had remained unsolved. In this paper, this controversial problem has been discussed for curdlan/oligo(dA) complexes utilizing two different energy transfer techniques. The first system consists of a combination of fluorescein-labeled curdlan and 3'-(or 5'-)tetramethyl-rhodamine (TAMRA)-labeled oligo(dA). The second system utilizes gold nanoparticles: that is, two curdlan chains were linked by a disulfide bond and after complexation with oligo(dA), the complex was immobilized on gold nanoparticles. In this system, TAMRA was attached to the 3'(or 5') end of oligo(dA) and the gold particle acted as a fluorescence quencher (energy acceptor). These experiments have led us to conclude that in the curdlan/oligo(dA) complex, parallel orientation is more favourable than anti-parallel orientation. These findings have enabled us to envision a clearer image for the complexation mode between beta-1,3-glucan polysaccharides and polynucleotides.
Cicada tibicen, a South American Species, with Records and Descriptions of North American Cicadas (1925)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Challenges in Assessing Hospital-Level Stroke Mortality as a Quality Measure (2012)

Hospital stroke mortality ratings varied considerably depending on whether ischemic, hemorrhagic, or total stroke mortality rates were used. Public reporting of stroke mortality measures should consider providing risk-adjusted outcome on separate stroke types.