gebhart/patrepeval huggingface dataset:
A Novel Diagnostic Method for Pulmonary Aspiration in a Murine Model: Immunocytochemical Staining of Milk Proteins in Alveolar Macrophages (2000)

Aspiration of foreign material into the lungs has been implicated in the etiology of a variety of pulmonary disorders. Although aspiration is a common clinical problem, its diagnosis represents a major challenge due to the lack of sensitive and/or specific tests. In this study, we evaluated the sensitivity and specificity of a novel diagnostic method in a murine model of milk aspiration. Under light anesthesia, BALB/c mice received either single or repeated intranasal instillation of milk. Control animals received sterile physiologic saline or were infected with respiratory pathogens in a similar manner. After isolation and cannulation of the trachea, mouse lungs were lavaged with PBS at various time points after the last aspiration event. Cells were recovered for Oil Red O (ORO) staining as well as immunocytochemistry for milk proteins: alpha-lactalbumin and beta-lactoglobulin. After single aspiration of milk, a large number of alveolar macrophages displayed a strong immunoreactivity for alpha-lactalbumin for 2-96 h. After single and repeated aspiration, the percentage of positive cells for alpha-lactalbumin was significantly higher when compared with ORO staining at 24, 48, and 72 h (p < 0.05). No immunoreactivity for milk proteins was found in alveolar macrophages obtained from our control groups. These findings demonstrate that immunocytochemical staining of milk proteins within alveolar macrophages represents a novel, sensitive, and specific test for the diagnosis of aspiration in a murine model.
Nutrition and severe brain injury. (1992)

Patients with severe brain injuries have increased energy expenditures and urinary nitrogen excretion. Hypozincemia, hypoferremia, increased levels of acute phase proteins, depressed levels of negative acute phase proteins, and weight loss are common in these patients. The specific mediators of these responses are not known. Nutritional support may beneficially affect outcome in these patients, but enteral feedings are often not tolerated in the acute phase of injury. Animal investigations suggest that total parenteral nutrition and hyperglycemia may increase neuronal injury and worsen outcome. We review the current literature on nutritional support of brain-injured patients and examine the premises on which nutrition supplementation are based. More work is needed to define the metabolic responses and nutritional requirements of patients who sustain central nervous system injury.
Mapping the neutralizing epitopes on the glycoprotein of infectious haematopoietic necrosis virus, a fish rhabdovirus (1996)

Twelve neutralizing monoclonal antibodies (MAbs) against the fish rhabdovirus, infectious haematopoietic necrosis virus (IHNV), were used to select 20 MAb escape mutants. The nucleotide sequence of the entire glycoprotein (G) gene was determined for six mutants representing differing cross-neutralization patterns and each had a single nucleotide change leading to a single amino acid substitution within one of three regions of the protein. These data were used to design nested PCR primers to amplify portions of the G gene of the 14 remaining mutants. When the PCR products from these mutants were sequenced, they also had single nucleotide substitutions coding for amino acid substitutions at the same, or nearby, locations. Of the 20 mutants for which all or part of the glycoprotein gene was sequenced, two MAbs selected mutants with substitutions at amino acids 230-231 (antigenic site I) and the remaining MAbs selected mutants with substitutions at amino acids 272-276 (antigenic site II). Two MAbs that selected mutants mapping to amino acids 272-276, selected other mutants that mapped to amino acids 78-81, raising the possibility that this portion of the N terminus of the protein was part of a discontinuous epitope defining antigenic site II. CLUSTAL alignment of the glycoproteins of rabies virus, vesicular stomatitis virus and IHNV revealed similarities in the location of the neutralizing epitopes and a high degree of conservation among cysteine residues, indicating that the glycoproteins of three different genera of animal rhabdoviruses may share a similar three-dimensional structure in spite of extensive sequence divergence.
Perylene Bisimide Dimers as Fluorescent “Glue” for DNA and for Base‐Mismatch Detection (2008)

Lights up! The characteristic fluorescence of perylene bisimide dimers can be used to study DNA hybridization and DNA aggregation (see scheme) as well as the presence of single-base-pair mismatches and deletions.
Sterol metabolism. VII. Autoxidation of cholesterol via hydroperoxide intermediates (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSterol metabolism. VII. Autoxidation of cholesterol via hydroperoxide intermediatesJohan E. Van Lier and Leland Leroy SmithCite this: J. Org. Chem. 1970, 35, 8, 2627–2632Publication Date (Print):August 1, 1970Publication History Published online1 May 2002Published inissue 1 August 1970https://pubs.acs.org/doi/10.1021/jo00833a031https://doi.org/10.1021/jo00833a031research-articleACS PublicationsRequest reuse permissionsArticle Views244Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Arming parvoviruses with CpG motifs to improve their oncosuppressive capacity (2008)

Oncolytic viruses represent novel tools for cancer treatment. Besides specifically killing cancer cells (oncolysis), these agents also provide danger signals, prompting the immune system to eliminate virus-infected tumours. As a consequence of oncolytic events, the innate and adaptive immune systems gain access to tumour antigens, which result in cross-priming and vaccination effects. Here the aim was to see whether we could enhance this adjuvant capacity by incorporating immunostimulatory CpG motifs into the single-stranded genome of an oncolytic parvovirus (H-1PV). We engineered 2 CpG-enriched H-1PV variants (JabCG1 and JabCG2), preserving both the replication competence and the oncolytic features of the parental virus. In keeping with their increased CpG content, the JabCG1 and JabCG2 genomes proved in vitro to be more potent triggers of TLR-9-mediated signalling than wild-type H-1PV DNA. Antitumour activity was evaluated in a rat model of MH3924A hepatoma lung metastases, where an infection with parental or modified viruses served as an ex vivo adjuvant to a subcutaneously administered autologous cell vaccine. In this setup, which excludes direct oncolytic effects on metastases, the JabCG2 vector displayed enhanced immunogenicity, inducing markers of cellular immunity (IFN gamma) and dendritic cell activation (CD80, CD86) in mediastinal (tumour-draining) lymph nodes. This led to a significantly reduced metastatic rate (50%) as compared to other vaccination schedules (H-1PV-, JabCG1-, JabGC- or mock-treated cells). The data provide proof of principle that increasing the number of immunostimulatory CpG motifs within oncolytic viruses makes it possible to improve their overall anticancer effect by inducing antitumour vaccination.
Hybrid analog-digital architectures for neuromorphic systems (2002)

Signal restoration is necessary to perform computations of significant complexity. In digital computers each state variable is restored to a binary value, but this strategy is incompatible with analog computation. Nevertheless, cortical neurons, whose major mode of operation is analog, are able to perform prodigious feats of computation. The authors' research on visual cortex suggests that cortical neurons are able to compute reliably because they are organized into populations in which the signal at each neuron is restored to an appropriate analog value by a collective strategy. The strategy depends on feedback amplification that restores an input signal towards a stored analog memory. This principle is similar to recall by autoassociative neural networks. Networks of cortical amplifiers can solve simple visual processing tasks. They are well-suited to sensory processing because the same principle that restores their analog signals can also extract meaningful features from ambiguous sensory input. The authors describe a hybrid analog-digital CMOS architecture for constructing networks of cortical amplifiers. This neuromorphic architecture is a step towards exploring analog computers whose distributed signal restoration permits them to perform reliably sequential computations of great depth.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Detection and Potential Utility of C-Reactive Protein in Saliva of Neonates (2014)

C-reactive protein is detectable in neonatal saliva and can predict abnormal serum CRP thresholds. Salivary CRP analysis represents a feasible screening tool for detecting abnormal serum CRP levels.
New Advances in Vehicular Technology and Automotive Engineering (2012)

An automobile was seen as a simple accessory of luxury in the early years of the past century. However, in the present days it's undeniable the amount of technology and human effort applied by the vehicular industry for developing high?quality vehicles, but still, cheap for the common person. In this context, this book tries not only to fill a gap by presenting new and updated subjects related to the vehicular technology and to the automotive engineering but also to provide guidelines for future research. This book is a result of many valuable contributions from worldwide experts of automotive's field. The amount and type of contributions were judiciously selected to cover as possible the widest range of research. The most recent and cutting?edge subjects can be found in this book, e.g., electronics, mechanics, materials, and manufacturing.
Noninvasive temperature measurement <i>in Vivo</i> using a temperature‐sensitive lanthanide complex and <sup>1</sup>H magnetic resonance spectroscopy (1996)

A new lanthanide complex, praseodymium-2-methoxyethyl-DO3A, was tested as a temperature indicator for 1H magnetic resonance spectroscopy under in vivo conditions, using a 2-T imaging system. The chemical shift of the methoxy group of the compound is strongly temperature dependent. In vitro, a shift change of -0.131 ppm/degree C was found. The signal was shifted by about -24 ppm relative to the water signal, allowing easy water suppression and signal identification in vivo. The body temperatures of eight anesthetized rats were measured in the liver after intravenous administration of 1 mmol/kg of the praseodymium complex under different heating conditions of the animal. The temperatures calculated from the spectra were in good agreement (deviation < +/- 1 degree C) with values obtained simultaneously with a thermocouple placed in the rectum of the animals.
Improving cold chain technologies through the use of phase change material (2012)

Gemstone Team FRESH
Wideband cancellation of interference in a GPS receive array (2000)

We have demonstrated that by using an adaptive space-time array the interference from multiple, strong interferers plus multipath can be canceled down close to the noise floor without producing serious loss or distortion of a GPS signal. Design criteria are presented and limitations are examined. We also compare space-time processing with suboptimum space-frequency processing, and demonstrate by simulation that for equal computational complexity space-time processing slightly outperforms suboptimum space-frequency processing.
Decoupled Affine Computation for SIMT GPUs (2017)

This paper introduces a method of decoupling affine computations---a class of expressions that produces extremely regular values across SIMT threads---from the main execution stream, so that the affine computations can be performed with greater efficiency and with greater independence from the main execution stream. This decoupling has two benefits: (1) For compute-bound programs, it significantly reduces the dynamic warp instruction count; (2) for memory-bound workloads, it significantly reduces memory latency, since it acts as a non-speculative prefetcher for the data specified by the many memory address calculations that are affine computations.
Compact MOSFET Modeling for Process Variability-Aware VLSI Circuit Design (2014)

This paper presents a systematic methodology to develop compact MOSFET models for process variability-aware VLSI circuit design. Process variability in scaled CMOS technologies severely impacts the functionality, yield, and reliability of advanced integrated circuit devices, circuits, and systems. Therefore, variability-aware circuit design techniques are required for realistic assessment of the impact of random and systematic process variability in advanced VLSI circuit performance. However, variability-aware circuit design requires compact MOSFET variability models for computer analysis of the impact of process variability in VLSI circuit design. This paper describes a generalized methodology to determine the major set of device parameters sensitive to random and systematic process variability in nanoscale MOSFET devices, map each variability-sensitive device parameter to the corresponding compact model parameter of the target compact model, and generate statistical compact MOSFET models for variability-aware VLSI circuit design.
A hardware architecture for surface splatting (2007)

We present a novel architecture for hardware-accelerated rendering of point primitives. Our pipeline implements a refined version of EWA splatting, a high quality method for antialiased rendering of point sampled representations. A central feature of our design is the seamless integration of the architecture into conventional, OpenGL-like graphics pipelines so as to complement triangle-based rendering. The specific properties of the EWA algorithm required a variety of novel design concepts including a ternary depth test and using an on-chip pipelined heap data structure for making the memory accesses of splat primitives more coherent. In addition, we developed a computationally stable evaluation scheme for perspectively corrected splats. We implemented our architecture both on reconfigurable FPGA boards and as an ASIC prototype, and we integrated it into an OpenGL-like software implementation. Our evaluation comprises a detailed performance analysis using scenes of varying complexity.
NASA Prototype All Composite Tank Cryogenic Pressure Tests to Failure with Structural Health Monitoring (2015)

This Paper will describe the results of pressurization to failure of 100 gallon composite tanks using liquid nitrogen.Advanced methods of health monitoring will be compared as will the experimental data to a finite element model.The testing is wholly under NASA including unique PZT (Lead Zirconate Titanate) based active vibration technology.Other technologies include fiber optics strain based systems including NASA AFRC technology, Acoustic Emission, Acellent smart sensor, this work is expected to lead to a practical in-Sutu system for composite tanks.
Utility of Alternate, Noncentromeric Chromosome 17 Reference Probe for Human Epidermal Growth Factor Receptor Fluorescence In Situ Hybridization Testing in Breast Cancer Cases (2018)

Context PathVysion-a US Food and Drug Administration-approved dual-probe human epidermal growth factor receptor ( HER2) fluorescence in situ hybridization (FISH) assay-provides the HER2: CEP17 ratio, a centromeric enumeration probe ratio for determining HER2 status in breast cancers. However, pericentromeric amplifications might then skew the HER2: CEP17 ratio, underestimating the HER2 status, which calls into question the use of CEP17 as the reference probe. Objective To analyze the utility of a noncentromeric chromosome 17 reference locus ( D17S122) to assess HER2 gene status in cases showing "nonclassical" FISH patterns with the CEP17 probe. Design The HER2 status of breast cancers accessioned in the years 2015-2017, displaying "nonclassical" or "equivocal" results by the PathVysion (Abbott Molecular Inc, Des Plaines, Illinois) HER2 DNA Probe Kit were reflex tested using an alternate FISH probe (ZytoLight SPEC/D17S122, ZytoVision, Bremerhaven, Germany) and interpreted with American Society of Clinical Oncology/College of American Pathologists 2013 guidelines. Results Of 37 cases, 17 were FISH equivocal. With the alternate D17S122 probe, 13 (76.4%) were reclassified as amplified, 3 (17.6%) as nonamplified, and a single case retained an equivocal result. Of the 17 cases with a chromosome 17 polysomy pattern, disomy, polysomy, and monosomy patterns were seen with 14 cases, 2 cases, and 1 case, respectively. Within the 17 cases with polysomy pattern, 3 (17.6%) demonstrated an unusual colocalization pattern of HER2 and CEP17, which was not observed with the alternate probe. Conclusions The denominator-stable alternate probe is a useful adjunct in the diagnostic armamentarium to analyze HER2 status in cases with FISH equivocal and complex patterns.
Error analysis of some finite element methods for the Stokes problem (1990)

We prove the optimal order of convergence for some two-dimensional finite element methods for the Stokes equations. First we consider methods of the Taylor-Hood type: the triangular <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper P 3 minus upper P 2"> <mml:semantics> <mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msub> <mml:mi>P</mml:mi> <mml:mn>3</mml:mn> </mml:msub> </mml:mrow> <mml:mo>−</mml:mo> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msub> <mml:mi>P</mml:mi> <mml:mn>2</mml:mn> </mml:msub> </mml:mrow> </mml:mrow> <mml:annotation encoding="application/x-tex">{P_3} - {P_2}</mml:annotation> </mml:semantics> </mml:math> </inline-formula> element and the <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper Q Subscript k Baseline minus upper Q Subscript k minus 1 Baseline comma"> <mml:semantics> <mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msub> <mml:mi>Q</mml:mi> <mml:mi>k</mml:mi> </mml:msub> </mml:mrow> <mml:mo>−</mml:mo> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msub> <mml:mi>Q</mml:mi> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi>k</mml:mi> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msub> </mml:mrow> <mml:mo>,</mml:mo> </mml:mrow> <mml:annotation encoding="application/x-tex">{Q_k} - {Q_{k - 1}},</mml:annotation> </mml:semantics> </mml:math> </inline-formula>, <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="k greater-than-or-equal-to 2"> <mml:semantics> <mml:mrow> <mml:mi>k</mml:mi> <mml:mo>≥</mml:mo> <mml:mn>2</mml:mn> </mml:mrow> <mml:annotation encoding="application/x-tex">k \geq 2</mml:annotation> </mml:semantics> </mml:math> </inline-formula>, family of quadrilateral elements. Then we introduce two new low-order methods with piecewise constant approximations for the pressure. The analysis is performed using our macroelement technique, which is reviewed in a slightly altered form.
Some Aspects of the Use of High Molecular Weight Synthetic and Natural Polymers as Additives to or Replacements for Gelatin in Photographic Products (1982)

A literature survey has been made of the addition to gelatin-containing layers and the partial replacement of gelatin by high molecular weight synthetic and natural polymers as a means of improving the physico-mechanical properties of such layers. Some attempts at the total replacement of gelatin as the binding agent for silver halide photographic emulsions are also reviewed.
Germs, Gas and the Gut; the Evolving Role of the Enteric Flora in IBS (2006)

Gas-related symptoms are common in irritable bowel syndrome (IBS), though their pathophysiology remains poorly understood, various studies invoking increased gas production, impaired gas transit, and increased sensitivity to gas. Recent evidence suggests a potential role for bacterial overgrowth in some patients with IBS; the study discussed herein provides further support for this concept by describing an amelioration of bloating and flatulence following a short course of the poorly absorbed antibiotic, rifaximin.
J.W.V 괴테의 조형예술에 관한 연구 (2013)

르네상스의 부활이 다시금 인간 정신의 여명을 밝힌 이래로 근대의 인문학자들은 고전 고대의 새로운 의의와 중요성을 새삼 인식하기 시작하였다. 여기서 말하는 고대는 그리스의 황금시대를 의미한다. 고대 그리스인들이 일궈낸 취미의 직접적인 산물이자 그 정화가 바로 프락시텔레스의 조각이자 익티노스의 건축이고 소포클레스의 희곡이며 호메로스의 서사시다. 인문학의 한 분과 학문으로서의 근대적 미술사학이 맹아를 틔우고 그 구체적인 형태를 드러내기 시작한 것도 바로 근대시기다. 이 학문분과의 발자취를 거슬러 오르면, 그것이 시작될 즈음에서 빛나는 정신을 만나게 되는데, 다름 아닌 요한 볼프강 폰 괴테다. 그는 학문적 엄밀성을 갖춘 본격적인 단계의 미술사학이 정립되기 이전에 미학적, 철학적 색채를 강하게 풍기며 후대의 예술이론가들 및 미술사학자들에게 풍부한 이론적 토양을 제공했다. 그리스의 고전문화는 인류의 영원한 유산이자 서양정신의 고향이다. 그래서 근대인들은 두 번 다시 실현될 수 없는 진정하고 완전한 인간성의 모범으로 생각했다. 르네상스기의 인문주의자, 미술가들이 고전 미술을 탐구하고 그 부흥을 꾀한 이래로, 18세기 들어 이탈리아 각지에서 고대유물의 발견, 발굴과 때를 같이하여 당시의 식자층 사이에 재차 고대 동경이 불길처럼 확산된 것은 마땅히 괴테의 선구자적 업적에 돌려져야 마땅하다.
Using semantic web technologies to describe automation objects (2006)

Continuous changes in markets have made manufacturing companies turn their shop floor strategies over to new manufacturing paradigms. Novel solutions are required in order to deal with rapid changeover of hardware and software components for the adjustment of production capacity and functionality. Hardware components for final solutions have achieved considerable maturity; meanwhile software components for control recently have been getting more attention. Function blocks from the standard IEC 61499 could offer a viable solution for algorithm encapsulation and distribution. The standard promotes encapsulation, therefore reusability by using open standards. Nevertheless, it is necessary that software applications are able to search on descriptions of software modules to automate the process of software reutilisation. Therefore, that could be possible if such modules are semantically described. This work enhanced the IEC 61499 reference model, and the Automation Objects reference model with semantics. An ontology of mechatronic devices has been developed, which classifies the most relevant features of hardware and software to utilise formal vocabulary. In addition, it is explained how a software agent can query information to a Reasoner engine over Automation Objects.