gebhart/patrepeval huggingface dataset:
Preliminary characterization of a major allergen of timothy grass pollen. (1975)

Previous studies with timothy pollen extracts demonstrated that a low molecular weight dialyzable fraction, antigen D, possessed the allergenic determinant of the major allergen of timothy pollen (allergen B). Bio-gel P-2 gel-filtration of the dialysate fraction resulted in the isolation of a fragment, antigen D3 with a molecular weight near 1000. The relationship of antigen D3 to the antigenic and allergenic determinants of allergen B was evaluated by passive cutaneous anaphylaxis (PCA) in guinea pigs sensitized with rabbit antitimothy sera and by allergen-induced histamine release from monkey lung tissue passively sensitized with the serum of timothy-sensitive patients. These studies demonstrated that 10 units of antigen D3 gave 1) a 70% inhibition of PCA reactions in guinea pigs challenged with allergen B, and 2) a 73% inhibition of allergen-induced histamine release from monkey lung tissue sensitized with timothy reagin and challenged with the crude pollen extract (WST). Although chemical characterization studies of the antigen D3 fragment are still being carried out it appears that the major components fo this fragment are 1) a flavonoid pigment - quercitin, 2) a disaccharide moiety - cellobiose, and 3) the amino acid threonine linked together in an )O-glycosidic type linkage.
Bacteriological studies of field soils, II. The effects of continuous cropping and various rotations (1912)

From a bacteriological study of soil plots under both continuous cropping and various crop rotations, these general conclusions were drawn:\n1. The rotation of crops caused the development of greater numbers of organisms in the soil and of greater ammonifying, nitrifying, and nitrogen-fixing power by the soil, than continuous cropping either to corn or to clover.\n2. Greater numbers of organisms, greater ammonifying, nitrifying, and nitrogen-fixing powers were found in a soil under a three year rotation of corn, oats, and clover, than in a soil under a two year rotation of corn and oats, or in a soil under a two-year rotation with clover, cowpeas or oats, turn en unner as green manure.\n3. The use of a green manure in a two-year rotation did not always increase the number of bacteria or the ammonifying, nitrifying, or nitrogen-fixing power of the soil, and it is suggested that the explanation may be sought in the moisture factor or it may be found in the introduction of such large amounts of organic matter.\n4. There was an indication that the crop present on the soil was of more importance from the bacterial standpoint than the previous cropping of the soil.\n5. The ammonification of dried blood and of cottonseed meal did not always run parallel.\n6. The nitrification of dried blood and of ammonium sulfate proceeded almost parallel.\n7. Nitrification and ammonification proceeded in the same direction.\n8. Evidence is supplied that bacterial activities and crop production are very closely related.
A dictionary of pharmacology and allied topics (1998)

This dictionary spans the practice of pharmacology, and of allied sciences insofar as they are related to it, with particular emphasis on the development, regulation and use of human medicine. It is offered to students as well as to professionals in pharmacology and allied sciences for reference and for browsing, and as a bedside book and travelling companion. Its size (approximately 2000 entries) is appropriate for these uses. The following are the features of this dictionary: it provides definitions of terms in pharmacology, both basic and clinical; it gives information on new medicine development and official regulations; and, it covers allied topics, including statistics, ethics, scientific misconduct, authorship, publication and law.
Dispara tu capacidad de salto: astucias para ayudar en el rendimiento (2008)

Ser capaz de saltar bien es crucial para el rendimiento, especialmente, en deportes que requieren un buen acondicionamiento y tecnica. John Shepherd examina las teorias y las estrategias practicas que pueden ayudar a maximizar tu capacidad de salto vertical y horizontal, y asi aumentar tu potencial deportivo.
A 9-16Gb/s clock and data recovery circuit with three-state phase detector and dual-path loop architecture (2004)

This paper describes the design and fabrication of a clock and data recovery circuit. This clock and data recovery circuit utilizes a novel half-rate three-state phase detector. The proposed phase detector is fully symmetric and has low propagation delay that makes it attractive for high speed applications. The proposed clock and data recovery circuit also implements a novel half-rate frequency detector. This frequency detector automatically remains disabled during the locked state. The proposed CDR circuit implements dual-path loop architecture. The dual path architecture suppresses the jitter peaking. The proposed clock recovery system is fabricated in a CMOS 0.18/spl mu/m technology. Measurements show that the CDR is functional for a data rate in the range of 9-16GHz. The circuit, including the output buffers, dissipates 310mW power from a 1.8V power supply for a 16Gb/s input data rate and 250mW power for a 10Gb/s input data rate. The peak-to-peak jitter of the recovered clock oscillating at 5 GHz and 8GHz are 10ps and 14ps, respectively. The effective die size is 1mm /spl times/ 0.8mm.
Correlation of Tumor Growth Inhibitory Activity of Macrophages Exposed to Adriamycin and Adriamycin Sensitivity of the Target Tumor Cells234 (1984)

Variant cell lines of the murine fibrosarcoma UV-2237, selected for doxorubicin [adriamycin (ADM)] resistance, were used to study the tumoricidal activity of macrophages that had been exposed to ADM. Free ADM (0.01-1 microgram/ml) was cytotoxic to the sensitive UV-2237M parent and to the partially sensitive UV-2237M-revertant cell lines, whereas the ADM-resistant UV-2237M ADMR line was unaffected by these levels of ADM. Macrophages harvested from the peritoneal cavities of mice given ip injections of 10 mg ADM/kg body weight 1 day or 4 days previously inhibited proliferation of the 3 cell lines, an effect that was directly correlated to the degree of ADM sensitivity of each cell line. Macrophages exposed in vitro to ADM (from 0.01 to 1 microgram/ml) inhibited the growth of, and eventually were cytolytic to, the parent and the revertant cell lines; these ADM-exposed macrophages did not affect the UV-2237M-ADMR cell line. The correlation between the antitumor effects of macrophages exposed to ADM and the ADM susceptibility of tumor cells suggests that ADM-exposed macrophages exert their effect by the release or transfer of the stored drug.
Defective Generation of a Humoral Immune Response Is Associated with a Reduced Incidence and Severity of Collagen-Induced Arthritis in Microsomal Prostaglandin E Synthase-1 Null Mice (2008)

Microsomal PGE synthase-1 (mPGES-1) is an inducible enzyme that acts downstream of cyclooxygenase and specifically catalyzes the conversion of PGH(2) to PGE(2). The present study demonstrates the effect of genetic deletion of mPGES-1 on the developing immunologic responses and its impact on the clinical model of bovine collagen-induced arthritis. mPGES-1 null and heterozygous mice exhibited decreased incidence and severity of arthritis compared with wild-type mice in a gene dose-dependent manner. Histopathological examination revealed significant reduction in lining hyperplasia and tissue destruction in mPGES-1 null mice compared with their wild-type littermates. mPGES-1 deficient mice also exhibited attenuation of mechanical nociception in a gene dose-dependent manner. In addition, mPGES-1 null and heterozygous mice showed a marked reduction of serum IgG against type II collagen, including subclasses IgG1, IgG2a, IgG2b, IgG2c, and IgG3, compared with wild-type mice, which correlated with the reduction in observed inflammatory features. These results demonstrate for the first time that deficiency of mPGES-1 inhibits the development of collagen-induced arthritis, at least in part, by blocking the development of a humoral immune response against type II collagen. Pharmacologic inhibition of mPGES-1 may therefore impact both the inflammation and the autoimmunity associated with human diseases such as rheumatoid arthritis.
Videotex and interactive services on tree‐and‐branch cable TV networks (1989)

Abstract Interactive services on tree‐and‐branch cable TV systems in the U.K. have been rather slow to emerge. This has been partly due to the high cost of the customers' terminals but is also due to the difficulty of passing keyboard data, from the customers, back over the cable network to the head‐end. This paper describes a new approach to these problems and shows that Videotex and other interactive services can be provided without major engineering changes to the network.
Amino acid substitution analysis of <i>E. coli</i> thymidylate synthase: The study of a highly conserved region at the N‐terminus (1992)

Amino acid substitution analysis within a highly conserved region of Escherichia coli thymidylate synthase (TS), using suppression of amber mutations by tRNA suppressors, has yielded a bank of 124 new mutationally altered TS proteins. These mutant proteins have been used to study the structure-function relationship of the Escherichia coli TS protein at the N-terminus corresponding to residues 20 through 35. This region contains a block of amino acids whose sequence has been well conserved among other known TS proteins from various organisms. Positions 20 through 25 contain a surface loop structure and positions 26 through 35 encompass a beta-strand. We find that residues surrounding a beta-bulge structure within the beta-strand are particularly sensitive to amino acid substitution, suggesting that this structure is maintained by a highly ordered packing arrangement. Three residues in the surface loop that are present at the base of the substrate binding pocket are also sensitive to amino acid substitution. The remainder of the conserved sites, including those at the dimer interface, are tolerant to most, if not all, of the substitutions tested.
<b>Figures of Lightness: Anorexia, Bulimia and Psychoanalysis</b> G. Ripa Di Meana London: Jessica Kingsley, 1999. pp. 269. £18.95 (pb). (2000)

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Applications Of Nonlinear Phase Conjugation In Compensated Active Imaging (1982)

Three approaches to active compensated imaging are proposed, in which one or more nonlinear phase conjugators effectively compensate for atmospheric turbulence-induced image degradations. In all cases the imaging system aperture and all auxiliary apparatus are located proximal to the active illumination aperture, in contrast to previously discussed system implementations, and the references which are employed are natural features of the image object.
Unified extensible firmware interface (UEFI) and secure boot: promise and pitfalls (2013)

UEFI is the replacement for an aging (1976) BIOS. It offers considerable advantages over its predecessor in terms of functionality and, possibly, security. However, it is very unlike BIOS, and computer professionals need to become familiar, if not adept, with UEFI. This technology is still relatively new, and definitely in an unfinished form. As with any new technology, there are implementation pitfalls that will be encountered.
An 8 kbit/s ACELP coder with improved background noise performance (1999)

This paper describes an 8 kbit/s ACELP speech coder with high performance for both speech and non-speech signals such as background noise. While the traditional waveform matching LPAS structure employed in many existing speech coders provides high quality for speech signals, it has significant performance limitations for, for example, background noise. The coder presented here employs a novel adaptive gain coding technique using energy matching in combination with a traditional waveform matching criterion providing high quality for both speech and background noise. The coder has a basic structure similar to that of the 7.4 kbit/s D-AMPS EFR coder, with a 10 th order LPC, high resolution adaptive codebook and a 4 pulse algebraic codebook. The performance for speech signals is equivalent to or better than that of state-of-the-art 8 kbit/s coders, while for background noise conditions the performance is significantly improved.
Decompositional logic synthesis approach for look up table FPGAs (2002)

In this paper, a technology driven logic synthesis approach for look up table FPGAs is presented. Decomposition and bottom-up construction are the key concepts of this approach. By using functionally complete compact modeling with set systems, technology mapping is trivial. The method offers correctness by construction and easy post-synthesis verification and uses a multiple criteria search algorithm for constructing near optimal solutions.
High temperature LGS SAW devices with Pt/WO/sub 3/ and Pd sensing films (2004)

This paper reports on the fabrication of high temperature LGS SAW devices to be used as gas sensors. SAW resonators and delay lines have been designed, fabricated, and tested up to 750/spl deg/C. An additional 7dB loss in the transmission coefficient, |S/sub 21/|, of the two port 167 MHz SAW resonators tested has been observed for operation at 750/spl deg/C with respect to room temperature. Original films have been fabricated for the two port SAW gas sensors tested from 250/spl deg/C to 550/spl deg/C. A combination of platinum/tungsten trioxide (Pt/WO/sub 3/) films has been used in the detection of C/sub 2/H/sub 4/ in N/sub 2/. In the detection of H/sub 2/ in N/sub 2/ an all palladium (Pd) metallic structure has been employed. Frequency variations up to 10 KHz for the 167 MHz high temperature SAW sensors were measured. The devices have been continuously cycled from 250/spl deg/C to 750/spl deg/C for periods up to six weeks, with degradations in the |S/sub 21/| response ranging from 2 to 7 dB. The high temperature LGS SAW devices and experiments reported in this work show the capability of these crystals to withstand prolonged exposure to temperatures ranging from 250/spl deg/C to 750/spl deg/C and to perform as high temperature gas sensors.
The solid state conversion reaction of cobalt oxide and iron fluoride thin films (2016)

Iron (II) fluoride and cobalt (II) oxide are candidate electrode materials for a new class of rechargeable lithium ion batteries known as conversion batteries. Although the energy storage capacity of these materials represents a significant improvement over that of conventional electrode materials, many challenges must be overcome before conversion batteries can become commercially viable. Chief among these challenges is a loss of energy storage capacity as a function of the number of charge-discharge cycles. In this study, FeF2 and CoO thin films have been studied as solid state analogues for lithium ion battery electrodes. These films were grown with different crystalline orientations and exposed to lithium in an ultra high vacuum chamber in order to simulate the discharge of a conversion electrode. The electronic structure and chemical phase of the films before and after exposure to lithium were characterized using x-ray photoemission spectroscopy (XPS), ultraviolet photoemission spectroscopy (UPS), and inverse photoemission spectroscopy (IPS). The depth and homogeneity of the conversion reaction in the thin films was measured as a function of lithium exposure using angle-resolved XPS (ARXPS). The crystalline structure and morphology were studied using scanning tunneling microscopy (STM) and transmission electron microscopy (TEM). For polycrystalline FeF2 and CoO films, the products of the solid state conversion reactions were similar to those observed in electrochemical measurements. However, parasitic reaction pathways were identified for both reactions. The products of these reaction were found to inhibit the full conversion of the thin films, and are possibly responsible for the poor reaction kinetics in electrochemical cells. Furthermore, the diffusion of lithium into the FeF2 and CoO surfaces, and the concomitant conversion reaction, was found to depend strongly on the orientation of the surface. These differences in diffusivity could partially be explained through geometric analyses of the crystalline structure of the films.
ALPHA‐FETOPROTEIN‐MEDIATED TARGETING—A NEW STRATEGY TO OVERCOME MULTIDRUG RESISTANCE OF TUMOUR CELLS <i>IN VITRO</i> (1997)

The possibility of overcoming the multidrug resistance of human malignant cells by using doxorubicin conjugated to alpha-fetoprotein (AFP) was studied. It was shown that this type of antitumour drugs, penetrating the cell by receptor-mediated endocytosis with AFP as a vehicle, raises the sensitivity of the tumour cells that are resistant due to the expression of the multidrug resistance gene mdr1. The sensitivity of antibiotic-resistant cell lines SKVLB (a human ovarian carcinoma) and MCF-7 AdrR (a human breast carcinoma) increased by 10- and 4-fold, respectively, when AFP-conjugated doxorubicin was used. The rationale of using human AFP-antitumour drug conjugates for the development of new chemotherapeutic approaches to cancer treatment is discussed.
Exploring the Selective Demethylation of Aryl Methyl Ethers with a <i>Pseudomonas</i> Rieske Monooxygenase (2018)

Biocatalytic dealkylation of aryl methyl ethers is an attractive reaction for valorization of lignin components, as well as for deprotection of hydroxy functionalities in synthetic chemistry. We explored the demethylation of various aryl methyl ethers by using an oxidative demethylase from Pseudomonas sp. HR199. The Rieske monooxygenase VanA and its partner electron transfer protein VanB were recombinantly coexpressed in Escherichia coli and they constituted at least 25 % of the total protein content. Enzymatic transformations showed that VanB accepts NADH and NADPH as electron donors. The VanA-VanB system demethylates a number of aromatic substrates, the presence of a carboxylic acid moiety is essential, and the catalysis occurs selectively at the meta position to this carboxylic acid in the aromatic ring. The reaction is inhibited by the by-product formaldehyde. Therefore, we tested three different cascade/tandem reactions for cofactor regeneration and formaldehyde elimination; in particular, conversion was improved by addition of formaldehyde dehydrogenase and formate dehydrogenase. Finally, the biocatalyst was applied for the preparation of protocatechuic acid from vanillic acid, giving a 77 % yield of the desired product. The described reaction may find application in the conversion of lignin components into diverse hydroxyaromatic building blocks and generally offers potential for new, mild methods for efficient unmasking of phenols.
Hints from a desert of incidents (1997)

tDCS can significantly improve the immediate postintervention cognitive function of healthy older adults and MCI elderly individuals. Additional longitudinal extensive sample studies are required to clarify the specific effects of tDCS on different cognitive domains, and the optimal tDCS parameters need to be explored to guide clinical practice.
Assembly development of 1.3 Tb/s full duplex optical module (2013)

A unique optoelectronic assembly has been developed for an optical module (OM) which allows for better than 1.3 Tb/sec full duplex data transfer into and out of a single ASIC die. The assembly process and initial system results are presented. The Optical Module assembly development focused on using standard semiconductor processing equipment and materials, wherever it could be done. Reliability tests, such as accelerated aging and thermal shock treatment, were performed successfully. The Optical Module components - an organic interposer (substrate), ASIC die, two 168-channel 1000nm optical dies (VCSELs and photodiodes) and two Micro Lens Arrays (MLA's) of 168 pixels each - are all assembled using flip-chip technology, allowing for a very high density data rate transfer. The assembly consists of five different flip-chip steps, followed by reflow or gluing and underfill. Flip-chip accuracy ranges from one to ten microns, depending on assembly step. Complete Optical Modules have been routinely assembled and tested in a small series production scale for more than a year now. These Optical Modules are a key component in the Compass-EOS all-optical backplane system. The Optical Module allows for total data transfer rate density of 67 Gb/s/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> with Bit Error Rate (BER) <; 1E-12. This is the highest optical data rate transfer and density that has been reported to-date for a single ASIC die.
Striatal dopaminergic function in restless legs syndrome (1999)

These PET findings support the hypothesis of central dopaminergic dysfunction in RLS.
Sound Sources of Screech Tone Radiated from Circular Supersonic Jet Oscillating in the Helical Mode (2002)

The generation mechanism of the screech tone in the helical oscillation mode is investigated using a series of instantaneous schlieren photographs. From the photographs, six evanescent sound sources are observed as prominent points along the jet axis. These sound sources move along circular orbits in the planes perpendicular to the jet axis and just downstream of the rear edges of each shock cell. The speed of moving sound sources is supersonic and the moving Mach cones generated behind the moving sound sources form the helical-shaped wave front of the screech tone. Existence of the moving Mach cones about the jet axis was confirmed by comparing schlieren photographs and drawings of the envelopes of the moving Mach cones. The helical vortical structure appears to overlap on the envelopes of the moving Mach cones.
A global motion characterization method using one-dimensional characteristic curves for image processing applications (2002)

A very hardware and computation efficient method for frame motion characterization is developed. Instead of dealing a 2-dimensional m/spl times/n picture elements, this algorithm generates two 1-dimensional vectors, by mathematically operating the luminance values of vertical and horizontal lines as the characteristic valves of x and y direction, respectively. The efficiency of this algorithm is demonstrated by decomposition of frame changes into various factors: the motion of objects, panning and zooming. Applications in automatic motion tracking system and image stabilizer are discussed.
Interface to the Routing System (I2RS) for Service Chaining: Use Cases and Requirements (2014)

Service chaining is the concept of applying an ordered set of services
to a packet or a flow. Services in the chain may include network
services such as load-balancing, firewalling, intrusion prevention,
and routing among others. Criteria for applying a service chain to a
packet or flow can be based on packet/flow attributes that span the
OSI layers (e.g., physical port, Ethernet MAC header information, IP
header information, transport, and application layer information).
This document describes use cases and I2RS (Information to the
Rousting System) requirements for the discovery and maintenance of
services topology and resources. It also describes use cases and I2RS
requirements for controlling the forwarding of a packet/flow along a
service chain based on packet/flow attributes.
A Study on the design and performance of electronic ballast for CCFL dimming control with frequency modulation (2003)

Commonly, CCFL dimming methods are used to either lamp current regulation or average current adjust feeding the CCFL inverter. And inverter operation frequency is higher than resonant frequency for safe operation. In this study, we design the half-bridge type series and parallel resonant converter circuit that switches at variable frequency modulation method to control the output power. This method has advantage such as low EMI and reduced harmonics, and it is convenient to dimming control with microprocessor. The validity of this study is confirmed from the simulation and experimental results.