gebhart/patrepeval huggingface dataset:
SESA: A Scalable Multi-channel Communication and Booking Solution for E-Commerce in the Tourism Domain (2013)

In the Tourism domain, e-Commerce is becoming the dominant means for value exchange i.e. selling and buying touristic services. Considering the latest developments of the Web in the direction of user-generated content, information sharing, online collaboration and social media, all gathered under the umbrella term of Web 2.0, the number of channels for value exchange and interaction with customers has drastically increased. Nowadays, successful e-Commerce solutions require the ability to communicate and engage with customers for a better visibility, reputation and in the end, increased revenue. In this paper, we introduce the Seekda Social Agent (SESA), an ongoing effort that aims to deliver a platform which will help businesses in the tourism domain in dealing with the challenge of improving and maintaining their communication needs in order to engage with their customers in an efficient and timely manner that ultimately supports effective and efficient value exchange. Our solution integrates various social media channels such as Facebook, Twitter, Linked In, YouTube and Flickr, disseminates information items with one click through a multitude of channels, shows feedback collected from customers, and supports engagement and value exchange based on the use of semantic technology.
Oncogenic transformation and mutation of C3H/10T 1/2 clone 8 mouse embryo fibroblasts by alkylating agents. (1981)

Two-hr treatments with N-methyl- and N-ethyl-N'-nitro-N-nitrosoguanidines and ethyl methanesulfonate induced ouabain-resistant mutants in C3H/10T 1/2 cells. The alkylnitronitroso-guanidines gave linear dose-response curves and were more potent mutagens than were ethyl methanesulfonate and methyl methanesulfonate. These differences in potency were largely due to differences in the half-lives of the alkylating agents in culture medium. Differences in mutation frequencies at equitoxic concentrations of the alkylating agents are considered to reflect differences in the chemical mechanisms of alkylation and mutagenesis by the compounds. However, the frequencies of mutations produced at equitoxic concentrations were not uniformly associated with the nucleophilic selectivities of the compounds as expressed by their published Swain-Scott substrate constants. Whether or not followed by repeated replating, the yield of oncogenically transformed foci of asynchronous cells after treatment with the alkylating agents was so low that we could not obtain dose-response curves, and the yield may not be significant. By contrast, in previous experiments with N-methyl-N'-nitro-N-nitrosoguanidines and polycyclic hydrocarbons in Syrian hamster embryo fibroblasts and with ultraviolet light and polycyclic hydrocarbons in C3H/10T 1/2 cells, transformation occurred to an equal or greater extent than mutation measured in the same cells.
Alkaline protease from Neurospora crassa. Purification and partial characterization. (1981)

A simple purification procedure has been developed for the extracellular alkaline protease from Neurospora crassa. Key steps in the purification were: 1) the choice of gelatin as the protein inducer, which induces optimally at a much lower concentration than other commonly employed protein inducers; 2) heat treatment, during which the inducer is digested by the protease; and 3) a concentration step that eliminates the usual precipitation procedures and removes much of the digested protein inducer. These procedures were followed by routine ion exchange chromatography and gel filtration. The preparation was homogeneous, as determined by gel electrophoresis and ultracentrifugal analyses. A molecular weight of approximately 30,500 was determined by amino acid analysis, gel electrophoresis, and sedimentation equilibrium. The protease has 100% activity from pH 6.0 to 10.0, is heat labile above 45 degrees C, and susceptible to autodigestion. Hydrolysis of the beta chain from insulin indicates a preferential cleavage on the carboxyl group side of neutral and aromatic amino acids.
Enhanced dissolution rate and oral bioavailability of simvastatin nanocrystal prepared by sonoprecipitation (2012)

Sonoprecipitation method can produce small and uniform simvastatin nanocrystals with an improved saturation solubility, dissolution rate and oral bioavailability.
Large elastic deformations of isotropic materials IX. The deformation of thin shells (1952)

Abstract The theory of the large elastic deformation of incompressible isotropic materials is applied to problems involving thin shells. The inflation of a circular diaphragm of such a material is studied in detail. It is found that the manner in which the extension ratios and curvatures vary in the immediate neighbourhood of the pole of the inflated diaphragm can be determined analytically. However, in order to determine their variation throughout the inflated diaphragm a method of numerical integration has to be employed. Although this is, in principle, valid for any form of the stored-energy function, the calculations are carried through only for the Mooney form. Finally, the problem of the inflation of a spherical balloon, which has already been dealt with by Green & Shield (1950), is discussed in further detail.
Manual of Geospatial Science and Technology (2001)

Prerequisites. Background. Remote Sensing. Geographical Information Systems. Applications Using GIS, GPS and Remote Sensing .
Multichannel intraluminal impedance accurately detects fasting, recumbent reflux events and their clearing (2002)

Multichannel intraluminal impedance (MII) is a new diagnostic test for gastroesophageal reflux disease (GERD). The objective of this report is to determine the accuracy of MII in detecting individual reflux events (REs) identified by pH probe and manometry, as well as their clearing in patients with severe GERD compared with normal volunteers. Ten severe GERD patients and 10 normal volunteers underwent simultaneous manometry [7 sites: gastric, lower esophageal sphincter, esophagus (4), pharynx], pH, and MII (6 sites in esophagus) for 15 min in the left and right recumbent posture while fasting. We found that patients had 30-fold more REs than normal volunteers (41 +/- 11 vs. 1.3 +/- 0.4), and 95% of all REs were detected by MII. An average 15-fold fall in impedance with liquid and fivefold rise with gas made REs and their composition easy to detect with MII. In the right recumbent posture, nearly all REs detected by MII were liquid (98%, 98/100). In contrast, all 283 REs detected by MII in the left recumbent posture were gas. Nearly all REs detected by MII were cleared (98%, 368/374). Mean acid clearing time was threefold longer (47 s) than clearing time by either manometry (15 s) or MII (13 s), primarily due to acid rereflux, i.e., additional acid REs during acid clearing. We conclude that MII is accurate in detecting REs identified by manometry and/or pH probe, their composition, and their clearing.
Single point mutation in tick-borne encephalitis virus prM protein induces a reduction of virus particle secretion (2004)

Flaviviruses are assembled to bud into the lumen of the endoplasmic reticulum (ER) and are secreted through the vesicle transport pathway. Virus envelope proteins play important roles in this process. In this study, the effect of mutations in the envelope proteins of tick-borne encephalitis (TBE) virus on secretion of virus-like particles (VLPs), using a recombinant plasmid expression system was analysed. It was found that a single point mutation at position 63 in prM induces a reduction in secretion of VLPs. The mutation in prM did not affect the folding of the envelope proteins, and chaperone-like activity of prM was maintained. As observed by immunofluorescence microscopy, viral envelope proteins with the mutation in prM were scarce in the Golgi complex, and accumulated in the ER. Electron microscopic analysis of cells expressing the mutated prM revealed that many tubular structures were present in the lumen. The insertion of the prM mutation at aa 63 into the viral genome reduced the production of infectious virus particles. This data suggest that prM plays a crucial role in the virus budding process.
Tight Binding of Influenza Virus Hemagglutinin to Its Receptor Interferes with Fusion Pore Dilation (2002)

Deletion of oligosaccharide side chains near the receptor binding site of influenza virus A/USSR/90/77 (H1N1) hemagglutinin (HA) enhanced the binding of HA to erythrocyte receptors, as was also observed with A/FPV/Rostock/34 (H7N1). Correlated with the enhancement of binding activity, the cell fusion activity of HA was reduced. A mutant HA in which three oligosaccharide side chains were deleted showed the highest level of binding and the lowest level of fusion among the HAs tested. The cell fusion activity of the oligosaccharide deletion mutant of HA, however, was drastically elevated when the binding activity was reduced by deletion of four amino acids adjacent to the receptor binding site. Thus, a reciprocal relationship was observed between the receptor binding and the cell fusion activities of H1/USSR HA. No difference was observed, however, in lipid mixing activity, so-called hemifusion, between wild-type (WT) and oligosaccharide deletion mutant HAs. Soluble dye transfer testing showed that even the HA with the lowest cell fusion activity was able to form fusion pores through which a small molecule such as calcein could pass. However, electron microscopic studies revealed that a large molecule such as hemoglobin hardly passed through the fusion pores formed by the mutant HA, whereas hemoglobin did efficiently pass through those formed by the WT HA. These results suggested that interference in the process of dilation of fusion pores occurs when the binding of HA to the receptor is too tight. Since the viral nucleocapsid is far larger than hemoglobin, appropriate receptor binding affinity is important for virus entry.
Java mobile agents on project JXTA peer-to-peer platform (2003)

Over the last year peer-to-peer (p2p) implementations have evolved from experimental to sophisticated systems. Mobile agents have a long e-commerce history dating back to the middle 1990's, and have not been generally accepted by the corporate, e-commerce mainstream. This is because of a misfit with the client-server model. With the advent of p2p networks, sub-network, ecosystem like communities, that are more suitable for mobile agent behaviour, now exists. In this paper we discuss the application of mobile agents to e-commerce on peer-to-peer (P2P) networks, as well as an implementation on the project JXTA, P2P platform. This implementation demonstrates both the suitability of mobile agents on p2p networks, and the ease of use of the project JXTA protocols.
Rifaximin, a Non-Absorbable Antibiotic, Improves the Symptoms of Irritable Bowel Syndrome (2005)

Purpose: Rifaximin, a newly approved non-absorbable antibiotic is reported to have better efficacy than neomycin in effecting a reduction in gut bacteria. In this study, we aim to demonstrate the effectiveness of rifaximin in improving IBS symptoms. Methods: Primary care IBS subjects meeting Rome I criteria (all subgroups) were recruited at two centers in the U.S. Subjects with recent antibiotic use, diabetes, history of bowel obstruction, known gastrointestinal disease, abdominal surgery, proton pump inhibitor use or antidepressant use were excluded from study. After consent, a 7-day stool diary was undertaken followed by a questionnaire and a lactulose breath test, the results of which were blinded to subjects and investigators. They were then randomized in double blind fashion to receive either placebo or rifaximin 400 mg p.o. t.i.d. for 10 days. During the 7 days following antibiotic therapy, subjects were asked to repeat the stool diary followed by a symptom questionnaire and lactulose breath test. The primary outcome was global improvement in IBS. Results: After exclusion criteria were applied, 91 subjects were consented and 87 of these (44 placebo, 43 rifaximin) were randomized. In the intention-to-treat analysis, rifaximin resulted in a 37.7 ± 5.8% overall improvement in IBS compared to 23.4 ± 4.3% with placebo (p < 0.05). With rifaximin, 37% of subjects were deemed clinical responders (defined as >50% improvement overall) compared to 16% for placebo (p < 0.05). Among subjects with diarrhea, clinical response was seen in 49% with rifaximin compared to 23% with placebo (p < 0.05). Bloating was also improved (p = 0.06). No difference was seen with constipation. As in previous study, methane on lactulose breath test was almost exclusively associated with constipation. Also, the degree of methane production correlated significantly with constipation severity (r = 0.49, p < 0.05), stool frequency (r =−0.622, p < 0.01) and Bristol stool score (r =−0.53, p < 0.05). Conclusions: Rifaximin is effective in improving the symptoms of IBS. Methane on breath test correlates with constipation in IBS patients.
An examination of price dispersion in an online retail marketplace (2010)

This dissertation is a compilation of three essays that analyze price dispersion in an online retail marketplace. Price dispersion is a measure of the variation in prices that sellers charge for products. Online price dispersion has been thoroughly analyzed in the past decade as it has numerous implications for firm pricing strategy as well as consumer welfare. Chapter 1 of this dissertation offers a literature review of price dispersion research, and discusses key explanations as to why this phenomenon exists on the web. Also, a literature review of shop-bots is presented as they are similar to online marketplaces and form the basis of the three studies. Chapter 2 is the first study, and it establishes the existence of price dispersion in online marketplaces and offers a comparison with price dispersion in shop-bots. It is determined that online marketplaces may have less variation than on shop-bots, yet the price dispersion is still high. Chapter 3 is the second study and it explains much of the dispersion found in the online marketplace through differences in seller service quality and seller reputation. A seller's reputation was found to be the key contributor to variation in the online marketplace hence, study 3, which is chapter 4 of this dissertation, employs an experimental approach designed to offer a perspective of buyers and sellers to determine why price varies with reputation and if consumers value the reputation score. It was determined that buyers prefer sellers with strong long run reputation scores more than sellers with strong short-term reputation scores. Based on these reputation scores sellers want to try to offer a higher price than consumers are willing to pay, and sellers think that a strong score conveys higher levels of trust than buyers believe. This mismatch between how sellers think consumers respond, and how the consumers actually respond could be another driver of price dispersion online. A discussion of the implications of these research studies is offered in Chapter 5.
Bioelectronics for Amperometric Biosensors (2013)

The Discrete-to-Integrated Electronics group (D2In), at the University of Barcelona, in partnership with the Bioelectronics and Nanobioengineering Group (SICBIO), is researching Smart Self-Powered Bio-Electronic Systems. Our interest is focused on the development of custom built electronic solutions for bio-electronics applications, from discrete devices to Application-specific integrated circuit (ASIC) solutions. The integration of medical and electronic technologies allows the development of biomedical devices able to diagnose and/or treat pathologies by detecting and/or monitoring pathogens, multiple ions, PH changes, and so on. Currently this integration enables advances in various areas such as microelectronics, microfluidics, microsensors and bio-compatible materials which open the door to developing human body Lab-on-a-Chip implantable devices, Pointof- Care in vitro devices, etc. In this chapter the main attention is focused on the design of instrumentation related to amperometrics biosensor: biopotentiostat amplifiers and lock-in amplifiers. A potentiostat is a useful tool in many fields of investigation and industry performing electrochemical trials [1], so the quantity and variety of them is very extensive. Since they can be used in studies and targets as different as the study of chemical metal conversions [2] or carcinogenic cells detection, neuronal activity detection or Deoxyribonucleic acid (DNA) recognition, their characteristics are very varied...
Hardware Prefetchers Leak: A Revisit of SVF for Cache-Timing Attacks (2012)

Micro-architectural features have an influence on security against cache attacks. This paper shows that modern hardware prefetchers enabled in cache memories to reduce the miss penalty, can be a source of information leakage with respect to cache-timing attacks. The work revisits the Side Channel Vulnerability Factor (SVF) proposed in ISCA¿12 and shows how to adapt the metric to assess the vulnerability of a prefetcher in cache-timing attacks. We use the modified metric denoted Timing-SVF, to show that standard prefetchers based on sequential algorithms can leak information in cache timing attacks. The findings have been established by experimental validations on a standard 128 bit cipher, called CLEFIA, designed by Sony Corporation Ltd. and used for light weight cryptography.
Organizer-Like Reticular Stromal Cell Layer Common to Adult Secondary Lymphoid Organs (2008)

Mesenchymal stromal cells are crucial components of secondary lymphoid organs (SLOs). Organogenesis of SLOs involves specialized stromal cells, designated lymphoid tissue organizer (LTo) in the embryonic anlagen; in the adult, several distinct stromal lineages construct elaborate tissue architecture and regulate lymphocyte compartmentalization. The relationship between the LTo and adult stromal cells, however, remains unclear, as does the precise number of stromal cell types that constitute mature SLOs are unclear. From mouse lymph nodes, we established a VCAM-1(+)ICAM-1(+)MAdCAM-1(+) reticular cell line that can produce CXCL13 upon LTbetaR stimulation and support primary B cell adhesion and migration in vitro. A similar stromal population sharing many characteristics with the LTo, designated marginal reticular cells (MRCs), was found in the outer follicular region immediately underneath the subcapsular sinus of lymph nodes. Moreover, MRCs were commonly observed at particular sites in various SLOs even in Rag2(-/-) mice, but were not found in ectopic lymphoid tissues, suggesting that MRCs are a developmentally determined element. These findings lead to a comprehensive view of the stromal composition and architecture of SLOs.
Insulin regulation of gluconeogenesis (2017)

The coordinated regulation between cellular glucose uptake and endogenous glucose production is indispensable for the maintenance of constant blood glucose concentrations. The liver contributes significantly to this process by altering the levels of hepatic glucose release, through controlling the processes of de novo glucose production (gluconeogenesis) and glycogen breakdown (glycogenolysis). Various nutritional and hormonal stimuli signal to alter hepatic gluconeogenic flux, and suppression of this metabolic pathway during the postprandial state can, to a significant extent, be attributed to insulin. Here, we review some of the molecular mechanisms through which insulin modulates hepatic gluconeogenesis, thus controlling glucose production by the liver to ultimately maintain normoglycemia. Various signaling pathways governed by insulin converge at the level of transcriptional regulation of the key hepatic gluconeogenic genes PCK1 and G6PC, highlighting this as one of the focal mechanisms through which gluconeogenesis is modulated. In individuals with compromised insulin signaling, such as insulin resistance in type 2 diabetes, insulin fails to suppress hepatic gluconeogenesis, even in the fed state; hence, an insight into these insulin-moderated pathways is critical for therapeutic purposes.
STEROIDAL CYCLIC KETALS. XXI.<sup>1</sup> THE PREPARATION OF 16β,21-EPOXIDO-STEROIDS (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSTEROIDAL CYCLIC KETALS. XXI.1 THE PREPARATION OF 16β,21-EPOXIDO-STEROIDSWilliam S. Allen and Seymour BernsteinCite this: J. Am. Chem. Soc. 1956, 78, 13, 3223–3224Publication Date (Print):July 1, 1956Publication History Published online1 May 2002Published inissue 1 July 1956https://doi.org/10.1021/ja01594a070Request reuse permissionsArticle Views48Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (273 KB) Get e-Alertsclose Get e-Alerts
Monument Wars: Washington, D.C., the National Mall, and the Transformation of the Memorial Landscape (2009)

Acknowledgments Introduction 1. A Monument to a Deceased Project 2. Covering Ground 3. The Mechanic Monster 4. Inventing Public Space 5. The Monument Transformed 6. The Conscience of the Nation 7. An End to War, an End to Monuments? Notes Selected Bibliography List of Illustrations Index
Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals (2002)

Supplementation of BH4 augments endothelium-dependent vasodilation in both normotensive and hypertensive individuals.
Surface-dependence of interfacial binding strength between zinc oxide and graphene (2015)

Density functional theory calculations have revealed strong surface-dependence of the binding strength between ZnO and graphene, attributed to induced charge redistribution owing to the in-plane and out-of-plane dipole moment of the oxide surface.
Durable Expression of Minicircle DNA-Liposome-Delivered Androgen Receptor cDNA in Mice with Hepatocellular Carcinoma (2014)

Our results show that an MC/liposome delivery system might improve the efficacy of gene therapy in patients with HCC.
Research Results in Dynamic Taxonomy and Faceted Search Systems (2007)

Metadata access to complex information bases through multidimensional dynamic taxonomies (aka faceted search) is rapidly becoming a hot topic both in research and in industry, where e-commerce applications based on this access paradigm are becoming pervasive. The dynamic taxonomy model was the first model to fully exploit multidimensional classification schemes and to integrate query and exploration into a single visual framework. We review a number of research results in data modeling, implementation, user interaction and emerging application areas of dynamic taxonomies and faceted search, originating from the Department of Informatics, University of Torino.