gebhart/patrepeval huggingface dataset:
Vitamin D Analogs Differentially Control Antimicrobial Peptide/“Alarmin”Expression in Psoriasis (2009)

Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic skin disease. Vitamin D analogs like calcipotriol have antipsoriatic effects and might mediate this effect by changing AMP expression. In this study, keratinocytes in lesional psoriatic plaques showed decreased expression of the AMPs beta-defensin (HBD) 2 and HBD3 after topical treatment with calcipotriol. At the same time, calcipotriol normalized the proinflammatory cytokine milieu and decreased interleukin (IL)-17A, IL-17F and IL-8 transcript abundance in lesional psoriatic skin. In contrast, cathelicidin antimicrobial peptide expression was increased by calcipotriol while psoriasin expression remained unchanged. In cultured human epidermal keratinocytes the effect of different vitamin D analogs on the expression of AMPs was further analyzed. All vitamin D analogs tested blocked IL-17A induced HBD2 expression by increasing IkappaB-alpha protein and inhibition of NF-kappaB signaling. At the same time vitamin D analogs induced cathelicidin through activation of the vitamin D receptor and MEK/ERK signaling. These studies suggest that vitamin D analogs differentially alter AMP expression in lesional psoriatic skin and cultured keratinocytes. Balancing AMP "alarmin" expression might be a novel goal in treatment of chronic inflammatory skin diseases.
Phytic acid level in infant soy protein islolate formulas and its effect on mineral availability to the rat / (1976)

This material was produced from a microfilm copy of the original document.While the most advanced technological means to photograph and reproduce this document have been used, die quality is heavily dependent upon the quality of the original submitted.The following explanation of techniques is provided to help you understand markings or patterns which may appear on this reproduction.1.The sign or "target" for pages apparently lacking from the document photographed is "Missing Page(s)".If it was possible to obtain the missing page(s) or section, they are spliced into die film along with adjacent pages.This may have necessitated cutting thru an image and duplicating adjacent pages to insure you complete continuity.2. When an image on the film is obliterated with a large round black mark, it is an indication that the photographer suspected that the copy may have moved during exposure and thus cause a blurred image.You will find a good image of the page in the adjacent frame.3. When a map, drawing or chart, etc., was part of the material being photographed the photographer followed a definite method in "sectioning" the material.It is customary to begin photoing at the upper left hand corner of a large sheet and to continue photoing from left to right in equal sections with a small overlap.If necessary, sectioning is continued again -beginning below the first row and continuing on until complete.4. The majority of users indicate that the textual content is of greatest value, however, a somewhat higher quality reproduction could be made from "photographs" if essential to the understanding of the dissertation.
Approximate keyword search in semantic trajectory database (2015)

Driven by the advances in location positioning techniques and the popularity of location sharing services, semantic enriched trajectory data have become unprecedentedly available. While finding relevant Point-of-Interest (POIs) based on users' locations and query keywords has been extensively studied in the past years, it is largely untouched to explore the keyword queries in the context of semantic trajectory database. In this paper, we study the problem of approximate keyword search in massive semantic trajectories. Given a set of query keywords, an approximate keyword query of semantic trajectory (AKQST) returns k trajectories that contain the most relevant keywords to the query and yield the least travel effort in the meantime. The main difference between AKQST and conventional spatial keyword queries is that there is no query location in AKQST, which means the search area cannot be localized. To capture the travel effort in the context of query keywords, a novel utility function, called spatio-textual utility function, is first defined. Then we develop a hybrid index structure called GiKi to organize the trajectories hierarchically, which enables pruning the search space by spatial and textual similarity simultaneously. Finally an efficient search algorithm and fast evaluation of the minimum value of spatio-textual utility function are proposed. The results of our empirical studies based on real check-in datasets demonstrate that our proposed index and algorithms can achieve good scalability.
Axonal Regeneration and Neuronal Function Are Preserved in Motor Neurons Lacking ß-Actin In Vivo (2011)

The proper localization of ß-actin mRNA and protein is essential for growth cone guidance and axon elongation in cultured neurons. In addition, decreased levels of ß-actin mRNA and protein have been identified in the growth cones of motor neurons cultured from a mouse model of Spinal Muscular Atrophy (SMA), suggesting that ß-actin loss-of-function at growth cones or pre-synaptic nerve terminals could contribute to the pathogenesis of this disease. However, the role of ß-actin in motor neurons in vivo and its potential relevance to disease has yet to be examined. We therefore generated motor neuron specific ß-actin knock-out mice (Actb-MNsKO) to investigate the function of ß-actin in motor neurons in vivo. Surprisingly, ß-actin was not required for motor neuron viability or neuromuscular junction maintenance. Skeletal muscle from Actb-MNsKO mice showed no histological indication of denervation and did not significantly differ from controls in several measurements of physiologic function. Finally, motor axon regeneration was unimpaired in Actb-MNsKO mice, suggesting that ß-actin is not required for motor neuron function or regeneration in vivo.
44‐1: <i>Invited Paper:</i> Micro‐LEDs for Technological Convergence between Displays, Optical Communications, and Sensing and Imaging Systems (2020)

Micro‐LED displays are now emerging rapidly towards commercialization. This novel compound semiconductor display technology has the potential to interface very effectively to advanced electronics, in particular Si CMOS, to create new forms of display which also interrogate and communicate with their environment in sophisticated ways.
Measurements of the Growth of the Ice Budget in a Persisting Contrail (1972)

An experiment was conducted with the NCAR Sabreliner to measure the ice water content (IWC) and the total ice budget within its contrail. Particle size distributions were measured with an optical-array particle size spectrormeter. The experiment was performed in a region of the atmosphere void of natural ice crystals (cirrus) but estimated to be above ice saturation and favorable to ice crystal growth. The IWC measured was found to be in excess of 0.1 gm m−3 near the contrail axis with average values of a few hundredths of a gram throughout the contrail. The measured water mass within the contrail was found to be four orders of magnitude greater than that computed as a combustion product. Average crystal sizes of nearly 0.5 mm allow for a transfer of moisture at generation level to much lower levels before re-evaporation. Because of the magnitude of the measured effect and its believed frequent occurrence, the overall effect of sub-tropopause jet traffic is likely to lower the water abundance at the most traveled levels. The total number of ice crystals produced is similar to the number of droplets expected in the initial liquid water contrail. All ice crystals appear to be produced through the freezing of droplets. The rate of diffusional spreading of the contrail corresponds to an eddy diffusivity of 1.5× 105cmsec−1. No turbulence was detected and the diffusion appears isotropic after the rapid dissipation of the initial vertically organized turbulent wake.
Immunohistochemical localization of bone morphogenetic proteins and the receptors in epiphyseal growth plate. (1998)

The expression of bone morphogenetic proteins (BMPs) and BMP receptors (BMPRs) in the epiphyseal growth plate has not been clarified. In this study, we studied immunohistochemically the spatial and temporal localization of BMP-2/4, osteogenic protein-1 (OP-1, or BMP-7), and BMP receptors (BMPR-IA, BMPR-IB, and BMPR-II) in the epiphyseal plate of growing rats. The proximal parts of tibia in growing rats were observed. At 12 weeks after birth, BMP-2/4 and OP-1 were expressed markedly in proliferating and maturing chondrocytes. BMPR-IA, IB and II were clearly co-expressed in proliferating and maturing chondrocytes, and the expression was decreased in hypertrophic chondrocytes. At 24 weeks, the expression of BMP-2/4 and OP-1 was decreased, but BMPRs were still well-expressed in proliferating chondrocytes. The temporal and spatial expression of BMP and BMPR suggests that BMP and BMP receptors play roles in the multistep cascade of enchondral ossification in the epiphyseal growth plate.
Isolation, Characterization and Identification of Potentially Probiotic Lactobacilli from Kimere; a Spontaneously Fermented pearl Millet Dough from Mbeere, Kenya (East Africa) (2007)

Effects of a Protein Optimized Diet Combined with Moderate Resistance Training on the Postoperative Course in Older Patients with Hip Fracture
An Enigma that is South Asia: India versus the Region (2013)

The South Asian Association for Regional Cooperation (SAARC) is now 28 years old, yet its success is nominal. That more important bilateral issues are discussed on the sidelines of SAARC Summits proves the point. Intra-regional trade is still miniscule compared to the region's overall share in the world trade. The biggest defaulter is India, the most prominent member of the group. The purpose of this paper is first to raise the question whether South Asia qualifies to be called a region, and second to argue that, given the problems it faces with most of its neighbours, India is forced to conclude that SAARC matters the least for it. For economic and strategic reasons, India's interests lie in global networking and in a balanced relationship with China. Since Chinese military, diplomatic, and economic presence in South Asia poaches into India's perceived sphere of influence, India's interest in SAARC is limited to that context for otherwise it neither provides large markets for India nor does it contribute to India's strategic policy. Inversely, such a situation justifies India's neighbours playing the China card to bargain with India though that card its losing its value. To buttress our arguments we have drawn from the region's historical experiences as well as from recent developments in international and South Asian politics, including domestic politics.
Set-based analysis of ML programs (1994)

Reasoning about program variables as sets of “values” leads to a simple, accurate and intuitively appealing notion of program approximation. This paper presents approach for the compile-time analysis of ML programs. To develop the core ideas of the analysis, we consider a simple untyped call-by-value functional language. Starting with an operational semantics for the language, we develop an approximate “set-based” operational semantics, which formalizes the intuition of treating program variables as sets. The key result of the paper is an O(n3) algorithm for computing the set based approximation of a program. We then extend this analysis in a natural way to deal with arrays, arithmetic, exceptions and continuations. We briefly describe our experience with an implementation of this analysis for ML programs.
Characterizing Alert and Browse Services of Mobile Clients (2002)

There is a fair amount of evidence that suggests that Internet access from wirelessly-connected mobile handheld devices is gaining popularity. However, there haven&apos;t been too many studies that have focused solely on analyzing the wireless Internet. In this paper, we study the notification and browse services provided by a large commercial web site designed specifically for users who access it via their cell-phones and PDAs. Unlike previous web studies that have analyzed browse services provided over wired networks, we focus primarily on browse and notification services provided over wireless channels. Specifically, we analyze the notification and browser traces to understand the system load, the type of content accessed, and user behavior. We discuss the implications of our findings for techniques such as multicast, query caching and optimization, and transport protocol design.
HPFP, a Model Propellant for pMDIs (2003)

A novel model propellant for the study of the properties of pMDIs (pressurized metered-dose inhalers) at atmospheric pressure is proposed and extensively characterized. The reasons for the choice of this liquid, with its advantages and drawbacks, are explained and justified. Comparison with existing fluorinated propellants is also documented.
Guided Waves - Inversion and Attenuation (2013)

Guided waves contain significant information about the near surface in seismic data, but prove difficult to remove through conventional velocity discrimination methods. Here, we analyse guided waves jointly with ground roll to characterise the near-surface properties and then we remove them by modelling methods. We begin by retrieving guided wave and ground-roll phase velocities. Then, we jointly invert them to build S- and P-wave velocity models using a robust multimodal inversion algorithm. Finally, we use the inferred guided wave and ground-roll properties to model the dispersive coherent noise and subtract it while preserving the signal.
Fast liquid chromatography. Investigation of operating parameters and the separation of nucleotides on pellicular ion exchangers (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFast liquid chromatography. Investigation of operating parameters and the separation of nucleotides on pellicular ion exchangersCsaba G. Horvath, B. A. Preiss, and Seymour R. LipskyCite this: Anal. Chem. 1967, 39, 12, 1422–1428Publication Date (Print):October 1, 1967Publication History Published online1 May 2002Published inissue 1 October 1967https://doi.org/10.1021/ac60256a003RIGHTS & PERMISSIONSArticle Views1720Altmetric-Citations517LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (770 KB) Get e-Alerts Get e-Alerts
Small molecule inhibitors of type III secretion in <i>Yersinia</i> block the <i>Chlamydia pneumoniae</i> infection cycle (2007)

Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re-differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaldehydes that specifically blocks the T3SS of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlamydia. Our results suggest a previously unexplored avenue for development of novel anti-chlamydial drugs.
Structural Analyses of Nucleotide Binding to an Aminoglycoside Phosphotransferase<sup>,</sup> (2001)

3',5"-Aminoglycoside phosphotransferase type IIIa [APH(3')-IIIa] is a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics while exhibiting striking homology to eukaryotic protein kinases (ePK). The structures of APH(3')-IIIa in its apoenzyme form and in complex with the nonhydrolyzable ATP analogue AMPPNP were determined to 3.2 and 2.4 A resolution, respectively. Furthermore, refinement of the previously determined ADP complex was completed. The structure of the apoenzyme revealed alternate positioning of a flexible loop (analogous to the P-loop of ePK's), occupying part of the nucleotide-binding pocket of the enzyme. Despite structural similarity to protein kinases, there was no evidence of domain movement associated with nucleotide binding. This rigidity is due to the presence of more extensive interlobe interactions in the APH(3')-IIIa structure than in the ePK's. Differences between the ADP and AMPPNP complexes are confined to the area of the nucleotide-binding pocket. The position of conserved active site residues and magnesium ions remains unchanged, but there are differences in metal coordination between the two nucleotide complexes. Comparison of the di/triphosphate binding site of APH(3')-IIIa with that of ePK's suggests that the reaction mechanism of APH(3")-IIIa and related aminoglycoside kinases will closely resemble that of eukaryotic protein kinases. However, the orientation of the adenine ring in the binding pocket differs between APH(3')-IIIa and the ePK's by a rotation of approximately 40 degrees. This alternate binding mode is likely a conserved feature among aminoglycoside kinases and could be exploited for the structure-based drug design of compounds to combat antibiotic resistance.
Carbohydrate deficient transferrin: a marker for alcohol abuse. (1989)

As the technique is fairly simple, sensitive, and inexpensive we suggest that it may be valuable in detecting alcohol abuse.
Synthese und Eigenschaften von Lipoaminosäuren und Lipodipeptiden des Ornithins / Synthesis and Properties of Lipo Amino Acids and Lipodipeptides of Ornithine (1991)

Lipo amino acids and α- as well as δ-connected lipodipeptides of ornithine were synthesized. The lipid portion was introduced to the amino group by acylating with hexadecanoyl chloride and to the carboxylic group by amidating with hexadecylamine or octadecylamine, respectively. Due to their amphiphilic properties these compounds were measured in a LANGMUIR-trough and thus their ability to form monomolecular films was examined. Dates from the surface pressure - area isotherms are listed in the following composition.
An Environmental Intervention Aimed at Increasing Physical Activity Levels in Low-Income Women (2007)

Physical activity levels were not significantly different between the groups. In a sample of low-income women who have multiple barriers, improving attitudes, expanding their knowledge of community resources, and providing physical activity opportunities in their neighborhoods are important intermediate steps toward initiation and maintenance of regular physical activity.
Pharmacokinetic Factors in the Clinical Use of Tryptophan (1984)

A patient with chronic pain and DSM-III unipolar and cyclothymic disorders was treated with L-tryptophan, 3000 mg before bed for 3 nights, and showed no response. She then began to take L-tryptophan, 1000 mg every 4 hours, with a high carbohydrate, low protein meal and immediately showed a clear improvement in exercise tolerance (reduced pain) and alleviation of affective symptoms. The importance of pharmacokinetic factors in the clinical use of L-tryptophan is emphasized.
Schaum und Schaumzerstörung – ein Überblick (1995)

Abstract Foam and Foam Breaking – A Review. Many technical processes produce foams which complicate the performance of a given process or even make it possible. Foam breaking, therefore, becomes necessary. This paper outlines well known and new methods of foam breaking as well as the breaking principles. For the example of sprinkling, the influence of selected parameters on the destruction efficiency and the formation of secondary foam can be demonstrated. After a discussion the properties of foam, stabilizing and destabilizing effects, possibilities of foam characterization and foam avoidance are presented.
Effect of gallium doping on the magnetocaloric effect of LaFe11.2Co0.7Si1.1 (2008)

The lattice parameter and magnetocaloric properties of three samples of LaFe11.2Co0.7Si1.1−xGax with x = 0, 0.03 and 0.05 have been investigated by X-ray powder diffraction and magnetization measurements. The lattice parameter increases slightly and the Curie temperature increases somewhat with increasing gallium content. However, a small amount of Ga doping into the sample decreases the magnetic entropy change of the sample. All the samples remain in the first-order magnetic phase transition. The most striking effect of the Ga doping is that the cooling capacity in the samples increases significantly. The maximum magnetic entropy change, −ΔSM, max, and the cooling capacity of the sample LaFe11.2Co0.7Si1.07Ga0.03 are 11.9 J·kg−1·K−1 and 254.8 J·kg−1, respectively.
Preclinical toxicology of a novel polymeric antitumour agent: HPMA copolymerdoxorubicin (PK1) (1998)

N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (PK1) is a novel polymeric anticancer agent containing doxorubicin (approximately 8 wt%) bound to the polymer backbone via a Gly-Phe-Leu-Gly peptidyl linker. The approximate LD50 of PK1 in MF1 mice after a single i.v. injection was 63 mg/kg (doxorubicin-equivalent). Single doses of PK1 were administered to MF1 mice at 22.5 or 45 mg/kg and blood samples taken on days 3, 7 and 14 for haematological examination and clinical chemistry. At day 14 all animals were sacrificed for necropsy. In a multiple dose study, PK1 was administered i.v. to MF1 mice or Wistar rats (20 animals per group) weekly for five consecutive weeks at doses of 12.0 or 22.5 mg/kg (mice) or 3 and 5 mg/kg (rats). After 31 days 10 animals from each group were sacrificed for necropsy and the remainder were sacrificed after 59 days. Blood samples were taken 3 days after administration of each dose and at the end of the experiment, and urine samples were collected on the day prior to sacrifice. Mortality in the single dose mouse and multiple dose rat studies was low. In the multiple dose mouse study 4/10 animals were killed in extremis before the scheduled day 31 and all animals died before day 37. PK1 induced a reduction in WBC and platelets in rats and mice shortly after treatment and RBC at later times, and in the single dose study alanine and aspartate aminotransferase levels were elevated at higher doses. Liver damage was seen only in rat tissue during histological examination. Other histological changes induced by PK1 include thymic and testicular atrophy, bone marrow depletion gastrointestinal tract changes and in the multiple dose study an increase in nuclear size in the proximal tubules of the kidney (although no changes in urine were seen). Recovery from these effects was seen in rats at 59 days. A PK1 dose of 20 mg/m2 (doxorubicin equivalent) was recommended as a safe dose for the start of Phase I clinical trials.