gebhart/patrepeval huggingface dataset:
Electrochemical Properties and ESR Characterization of Mixed Valence α-[XMo<sub>3</sub><sub>-</sub><i><sub>x</sub></i>V<i><sub>x</sub></i>W<sub>9</sub>O<sub>40</sub>]<i><sup>n</sup></i><sup>-</sup> Heteropolyanions with X = P<sup>V</sup> and Si<sup>IV</sup>, <i>x</i> = 1, 2, or 3 (1996)

Electrochemical behavior of the alpha-[SiMo(3)(-)(x)()V(x)()W(9)O(40)]((4+)(x)()())(-) and alpha-[PMo(3)(-)(x)()V(x)()W(9)O(40)]((3+)(x)()())(-) anions with x = 1, 2, or 3 were studied. Electrochemical reduction of each compounds was consistent with its Mo/V ratio, reduction of vanadium and molybdenum atoms occurring in the +0.6 to -0.6 V potential range. The one-electron-reduced species were prepared by electrolysis and then characterized by ESR spectroscopy. The g and A values for V(4+)ions appeared to depend on the nature of the surrounding atoms (Mo(VI), W(VI), and V(V)). In solution at 330 K, the ESR spectrum of the protonated alpha-H[SiMoV(IV)VW(9)O(40)](6)(-) anion displayed 29 superhyperfine lines which were related to the partial localization of the electron on one vanadium nucleus. The ESR spectra at room temperature for the divanadium-substituted anions showed a strong anisotropy of the A tensor which would be related to the electron transfer along a preferential axis. An isolated V(4+) signal was not observed, even at 12 K, indicating that the electron is never firmly trapped on one single vanadium atom.
Evaluation effects of biobased plasticizer on the thermal, mechanical, dynamical mechanical properties, and permanence of plasticized PVC (2010)

Abstract Sunflower oil (SO) is a renewable resource that can be epoxidized, and the epoxidized SO has potential uses as an environmentally friendly in polymeric formulations, especially for poly (vinyl chloride) (PVC). Epoxidized sunflower oil (ESO) was prepared by treating the oil with peracetic acid generated in situ by reacting glacial acetic acid with hydrogen peroxide. Epoxidation was confirmed using spectroscopic and titration methods. ESO was used as a coplasticizer in PVC for the partial replacement of di‐(2‐ethyl hexyl) phthalate (DEHP). The effect of ESO on the thermal stability of plasticized PVC was evaluated by using synmero scale for the sheets. In presence of ESO plasticized PVC samples showed a reduction in discoloration and the number of conjugated double bonds. By using thermogravimetry, the incorporation of 15/45 of ESO/DEHP in PVC presents the lowest weight loss. The results of the shore hardness and mechanical properties showed that a proportion of DEHP could be substituted by ESO. By use of DMA, the formulation which contains 25 % wt of ESO in plasticizer system shifts the glass transition temperature ( T g ) to ambient temperature. The migration phenomenon was studied on PVC based samples plasticized with DEHP and ESO in varying amounts. The migration was monitored by the weight loss percentage of the samples immersed into n‐hexane or heated in an oven. The amount of extracted or volatilized DEHP is proportional to the added ratio of ESO in plasticizer system. All of this favored the partial replacement of DEHP by ESO as biobased plasticizer for flexible PVC. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Complex Models for the Study of Gene Function in Cardiovascular Biology (1994)

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and ...Read More
Two motifs essential for nuclear import of the hnRNP A1 nucleocytoplasmic shuttling sequence M9 core (2006)

Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 regulates mRNA genesis. It shuttles between the nucleus and cytoplasm. Its shuttling signal is a 38-residue sequence M9. We studied the nuclear import and export of M9 by mutational analysis. Heterokaryon assay indicated that the 19-residue sequence SNFGPMKGGNFGGRSSGPY (M9 core) is necessary and sufficient for shuttling. Moreover, M9 core mutation revealed that in addition to the hitherto characterized N-terminal motif SNFGPMK, the C-terminal motif PY is crucial for nuclear import as well as for binding to transportin. Key residues of the motifs are conserved in the shuttling signals of hnRNP D and JKTBP.
Tribute to Christiane Keck, Founding Editor (2011)

Professor Christiane Keck, Professor Emerita of German and former Head of the Department of Foreign Languages and Literatures [as of January 1, 2012, the School of Languages and Cultures] at Purdue University, provided the driving force for the creation of Global Business Languages in the mid-1990s. From its beginning in 1996 she served as Editor of the journal, and although she retired from the university in 2002, she continued her editorship until 2010. Last year when she announced she would be leaving the journal, it was too late for us in our production schedule to offer more than brief thanks for her long service and devotion to business German, business languages in general, and the journal. In this Tribute, several of her colleagues share their thoughts upon her departure from the journal.
Utilizing the effect of relative delay on energy dissipation in low-power on-chip buses (2004)

This paper presents an analysis of how the power dissipation of on-chip buses is affected by introducing a relative delay between the switching lines. Relative delay is shown to reduce the dissipated power of oppositely switching lines while causing a power penalty for similarly switching lines. A new low-power bus scheme that uses this effect is proposed and analyzed. As the introduced delay increases, the achieved power reduction increases while decreasing the bus throughput. Thus, a tradeoff between power reduction and throughput is required when selecting the imposed relative delay. The proposed low-power scheme, dynamic delayed line bus (DDL) scheme, led to a power reduction of up to 25%, 33%, and 42% when applied to data, address, and differential buses, respectively. Simple DDL hardware is designed and implemented in a 0.18-/spl mu/m TSMC CMOS technology and applied to a 4500-/spl mu/m long Metal4 bus. Circuit simulation results for different bus widths are presented.
Peering Beneath the Surface: Novel Imaging Techniques to Noninvasively Select Gametes and Embryos for ART (2013)

Embryo imaging has long been a critical tool for in vitro fertilization laboratories, aiding in morphological assessment of embryos, which remains the primary tool for embryo selection. With the recent emergence of clinically applicable real-time imaging systems to assess embryo morphokinetics, a renewed interest has emerged regarding noninvasive methods to assess gamete and embryo development as a means of inferring quality. Several studies exist that utilize novel imaging techniques to visualize or quantify intracellular components of gametes and embryos with the intent of correlating localization of organelles or molecular constitution with quality or outcome. However, the safety of these approaches varies due to the potential detrimental impact of light exposure or other variables. Along with complexity of equipment and cost, these drawbacks currently limit clinical application of these novel microscopes and imaging techniques. However, as evidenced by clinical incorporation of some real-time imaging devices as well as use of polarized microscopy, some of these imaging approaches may prove to be useful. This review summarizes the existing literature on novel imaging approaches utilized to examine gametes and embryos. Refinement of some of these imaging systems may permit clinical application and serve as a means to offer new, noninvasive selection tools to improve outcomes for various assisted reproductive technology procedures.
On Attempted Oxidative Cyclisation of Isomeric<i>N,N'</i>-Diphenylphenylenediamines and Their<i>N,N</i>'-Dimethyl Derivatives by Palladium(II) Acetate and Uv Light (2000)

Abstract The cyclisation of N,N'-diphenyl-o-, m- and p-phenylenediamines and their N,N'-dimethyl derivatives by palladium(II) acetate and UV light separately led to both bis-cyclisation, furnishing indolocarbazoles, and mono-cyclisations with cleavage as well as retention of one substituent, producing substituted carbazoles.
Post cardiac transplantation lymphoproliferative disorder presenting as t(8;14) Burkitt leukaemia/lymphoma treated with low intensity chemotherapy and rituximab (2009)

In the context of PTLD the prognostic significance of advanced stage EBV-driven BLL with the t(8;14) translocation may be different to that in immunocompetent children.
Fungicides Improve Field Performance of Stored Loblolly and Longleaf Pine Seedlings (1996)

Abstract Seedlings of loblolly and longleaf pine lifted in December, January, and February were treated with either benomyl or ridomil before cold storage. Along with an untreated control, they were planted after cold storage of less than 1 wk, 3 wk, and 6 wk. Survival was measured in mid-June after planting, and after 1 and 4 yr in the field. Total height was measured after 4 yr. The fungicide application increased survival of both species lifted in December or February and was beneficial to longleaf pine seedlings regardless of storage duration. Fungicide-treated longleaf pine seedlings had greater mean 4 yr height than the controls, but fungicides did not affect the height of loblolly pine. South. J. Appl. For. 20(1): 5-9.
A fully programmable sampled-data analog CMOS filter with transfer-function coefficients determined by timing (1987)

A CMOS analog signal processor which is as programmable as a digital one is discussed. This processor does not use known switched-capacitor techniques, nor does it contain any selectable capacitor (or resistor) arrays. Instead, it operates on a pulsewidth control principle in which the value of each branch gain is determined by the duty cycle of a single digitally controlled analog transmission gate. A 4-/spl mu/m single-poly CMOS test IC containing all the critical analog functions was designed to demonstrate this principle at sampling frequencies up to 100 kHz. All of the processors described allow individual programming of each transfer function coefficient; one also features programmable topology, and another is capable of simultaneous multiple-signal multiple-transfer-function processing. A typical integrated fully programmable biquad shows 80-dB dynamic range.
Converted-Wave Moveout and Parameter Estimation for Transverse Isotropy (1999)

For transverse isotropy with a vertical symmetry axis (TIV, or polar anisotropy), it is difficult to obtain the vertical velocities and build a velocity-depth model from reflection data, without borehole or log information.
Technological approach for cultural heritage: augmented reality (2003)

Augmented reality (AR) systems allow the user to see a combination of a mixed scenario, generated by a computer, in which virtual objects are merged with the real environment. The calibration between the two frames, the real world and the virtual environment, and the real time tracking of the user are the most important problems for the AR application implementations. Augmented reality systems are proposed as solutions in many application domains. In this paper we addressed the aspect related to the development of AR applications in the cultural heritage field. Possible future applications are described, including the use of haptic interfaces in AR systems, designed at PERCRO.
Characterization of saccharolytic Bacteroides and Prevotella isolates from infected dog and cat bite wounds in humans (1997)

Saccharolytic, nonpigmented, anaerobic gram-negative rods isolated from infected dog and cat bite wounds in humans have been poorly characterized, and most are not included in the databases of kits used for anaerobic identification; thus, they are problematic for clinical laboratories to identify. Fifty strains isolated from such wounds were characterized with commercial kits for preformed-enzyme detection, carbohydrate fermentation, and other biochemical tests. PCR fingerprinting was performed on these strains to further characterize subgroups within these species. Bacteroides tectum is a frequent isolate in bite wounds and resembles Prevotella bivia in colony morphology and saccharolytic activity, except that it grows in 20% bile and hydrolyzes esculin. Profile numbers generated by various kits associate B. tectum with P. bivia, Prevotella oralis group, or Prevotella melaninogenica. PCR fingerprinting identified at least four subgroups and confirmed the heterogeneous nature of this species. Prevotella heparinolytica was also frequently isolated from these bite wounds. It produces indole and generates a profile number in preformed-enzyme kits that is usually associated with Bacteroides uniformis. However, it is bile sensitive and quite distinct from the Bacteroides fragilis group of anaerobes. The PCR fingerprint profiles generated by strains of P. heparinolytica were very similar to that of the type strain and to each other. Prevotella zoogleoformans, occasionally isolated from dog and cat bite wounds in humans, resembles P. heparinolytica except for a negative indole test. Clinical laboratories should be aware of the characteristics of these animal species when identifying isolates from animal bite wounds in humans.
Spectroscopic and nonlinear-optical applications of a tunable β-barium borate optical parametric oscillator (1993)

A pulsed β-barium borate optical parametric oscillator (BBO OPO) serves as the tunable source of coherent radiation for linear- and nonlinear-optical spectroscopic applications: photoacoustic absorption, optical double resonance, and coherent Raman spectroscopy. The BBO OPO is used spectroscopically either as a free-running broadband device with single-shot multiplex detection or as a continuously tunable narrow-band device controlled by injection seeding. A single BBO crystal offers a wide fundamental OPO tuning range (0.41–2.7 μm) that can be extended further into the ultraviolet and infrared regions by additional nonlinear-optical stages. Pumped at 355 nm by a single-mode Nd:YAG laser, the BBO OPO operates with high conversion efficiency and damage threshold and adequate beam quality for spectroscopic and nonlinear-optical purposes.
Towards a first vertical prototyping of an extremely fine-grained parallel programming approach (2001)

Explicit-multithreading (XMT) is a parallel programming approach for exploiting on-chip parallelism. XMT introduces a computational framework with 1) a simple programming style that relies on fine-grained PRAM-style algorithms; 2) hardware support for low-overhead parallel threads, scalable load balancing, and efficient synchronization. The missing link between the algorithmic-programming level and the architecture level is provided by the first prototype XMT compiler. This paper also takes this new opportunity to evaluate the overall effectiveness of the interaction between the programming model and the hardware, and enhance its performance where needed, incorporating new optimizations into the XMT compiler. We present a wide range of applications, which written in XMT obtain significant speedups relative to the best serial programs. We show that XMT is especially useful for more advanced applications with dynamic, irregular access pattern, where for regular computations we demonstrate performance gains that scale up to much higher levels than have been demonstrated before for on-chip systems.
Identification of tumor-associated antigens by large-scale analysis of genes expressed in human colorectal cancer. (2008)

Despite the high prevalence of colon cancer in the world and the great interest in targeted anti-cancer therapy, only few tumor-specific gene products have been identified that could serve as targets for the immunological treatment of colorectal cancers. The aim of our study was therefore to identify frequently expressed colon cancer-specific antigens. We performed a large-scale analysis of genes expressed in normal colon and colon cancer tissues isolated from colorectal cancer patients using massively parallel signal sequencing (MPSS). Candidates were additionally subjected to experimental evaluation by semi-quantitative RT-PCR on a cohort of colorectal cancer patients. From a pool of more than 6000 genes identified unambiguously in the analysis, we found 2124 genes that were selectively expressed in colon cancer tissue and 147 genes that were differentially expressed to a significant degree between normal and cancer cells. Differential expression of many genes was confirmed by RT-PCR on a cohort of patients. Despite the fact that deregulated genes were involved in many different cellular pathways, we found that genes expressed in the extracellular space were significantly over-represented in colorectal cancer. Strikingly, we identified a transcript from a chromosome X-linked member of the human endogenous retrovirus (HERV) H family that was frequently and selectively expressed in colon cancer but not in normal tissues. Our data suggest that this sequence should be considered as a target of immunological interventions against colorectal cancer.
Kinetic constraints on the loss of organic chemicals from contaminated soils: Implications for soil‐quality limits (1995)

Abstract Generic or site‐specific soil‐quality limits for organic contaminants have been adopted or proposed in various countries in an effort to control or assess contamination. The most comprehensive generic limits, established in the Netherlands, distinguish between background concentrations for naturally occurring substances and analytical detection limits for man‐made organic compounds (target values) and threshold concentrations above which remediation may be necessary (intervention values). These are being employed to highlight contaminated sites that require treatment/remediation, ideally resulting in the reduction of the compounds of concern. These limits have been derived in a number of ways but are largely based on professional judgment, usually on information concerning pathways of human exposure, phytotoxicity, and ecotoxicological effects. Effective remediation of contaminated soils is frequently limited by the slow kinetics of contaminant loss from soils under prevailing environmental conditions. This is frequently underestimated, even though it may be of fundamental importance in determining the success of treatment/remediation with respect to the assigned quality limits. This is because loss of contaminants from soils is often biphasic, whereby a short period of rapid dissipation is followed by a longer period of contaminant release. Dissipation processes, including leaching and volatilization, exhibit similar behavior. The primary rate‐limiting factors governing this behavior are postulated to be fundamental sorption/ desorption mechanisms, including intraparticle diffusion, intrasorbent diffusion and chemisorption, which control the distribution of contaminant between the solid and aqueous or gaseous phases of soils and, hence, the supply of contaminant available to the various dissipation processes. In this article, we consider the relevance of biphasic desorption kinetics to existing soil‐quality limits. We contend that the concentration of a given contaminant in a given soil when the “residual” phase of dissipation is reached represents an intrinsic kinetic constraint to the remediation of contaminated soil. Because of the effects of the primary rate‐limiting mechanisms discussed above, it is unlikely that (in the absence of any engineering solution to the problem) any appreciable change in the contaminant concentration will occur over practical time scales under prevailing environmental conditions for a given soil. We define this contaminant concentration as a kinetically constrained soil quality limit (KCSQL) and apply it to selected examples of contaminant dissipation from the literature, including polychlorinated biphenyls, polynuclear aromatic hydrocarbons, industrial solvents, and pesticides in a range of soils. Finally, we examine the relationship between the derived KCSQLs and the Dutch “cleanup” values and soil‐quality criteria adopted in other countries.
Future flight test plans of an axisymmetric hydrogen-fueled scramjet engine on the Hypersonic Flying Laboratory (1996)

Under a contract with NASA, a joint Central Institute of Aviation Motors (CIAM) and NASA team is preparing to conduct the fourth flight test of a dual-mode scramjet aboard the CIAM Hypersonic Flying Laboratory, “Kholod.” Ground-launch, rocket boosted by a modified Russian SA-5 missile, the redesigned scramjet is to be accelerated to a new maximum velocity of Mach 6.5. This should allow for the first-time measurement of the fully supersonic combustion mode. The primary program objective is the flight-to-ground correlation of measured data with preflight analysis and wind-tunnel tests in Russia and potentially in the United States. This paper describes the development and objectives of the program as well as the technical details of the scramjet and SA-5 redesign to achieve the Mach 6.5 aim test condition. The purpose and value of a joint Russian-American program to attain overall hypersonic air-breathing technology objectives are discussed. Finally, the current project status and schedules to reach the final flight launch are discussed.
Capacity Release by Shunt Capacitor Placement on Distribution Feeders: A New Voltage-Dependent Model (1982)

A new voltage-dependent methodology for shunt-capacitor compensation of primary distribution feeders is presented. A generalized computer-based procedure is described for optimally sizing and placing any specified number of fixed shunt capacitors while accounting for voltage variation along the feeder. The procedure is applied to a physically-existing feeder with known P, Q loads to yield results for capacity release exactly comparable to those from an optimal power flow. The superiority of the new methodology over existing methods is demonstrated.
Fludarabine and neurotoxicity in engineered T-cell therapy (2018)

Adoptive T-cell therapy, incorporating engineered T cell receptors (TCRs) or chimeric antigen receptors (CARs), target tumor antigens with high affinity and specificity. To increase the potency of adoptively transferred T cells, patients are conditioned with lymphodepleting chemotherapy regimens prior to adoptive T-cell transfer (ACT), and data suggest that fludarabine is an important component of an effective regimen. In a recent clinical trial using CAR-T cells engineered to target the CD19 B-cell antigen to treat acute lymphoblastic leukemia, JCAR-015 (NCT02535364), two patient deaths due to cerebral edema led to trial suspension. The lymphodepleting agent fludarabine was suggested as the causative agent, in part due to its known association with neurotoxicity and its ability to induce greater potency. In a similar CAR-T study also incorporating fludarabine in the preconditioning regimen, ZUMA-1 (NCT02348216), one patient died of cerebral edema. However, subsequent deaths in the JCAR-015 study after removal of fludarabine and improved understanding behind the mechanisms of CAR-T-related encephalopathy syndrome (CRES) indicate that fludarabine is not the primary causative agent of cerebral edema and that it can be safely incorporated into the preconditioning regimen for ACT. Since entering clinical use in the late 1980s as a chemotherapy agent, fludarabine and similar analogs have been associated with lethal neurological toxicity, yet the manifestation and timing of symptoms are distinct to those observed recently in ACT. Herein, we review the history of fludarabine development as a chemotherapeutic agent, and discuss the safety of its continued use in preconditioning regimens for ACT.