gebhart/patrepeval huggingface dataset:
In vivo effects of recombinant interleukin-11 on myelopoiesis in mice (1993)

Purified recombinant human interleukin-11 (rhuIL-11) was assessed for its in vivo effects on the proliferation and differentiation of hematopoietic progenitors as well as its capacity to accelerate the recovery of a drug-suppressed hematopoietic system. Dosage and time sequence studies demonstrated that administration of IL-11 to normal mice resulted in increases in absolute numbers of femoral marrow and splenic myeloid (granulocyte-macrophage colony-forming unit [CFU-GM], burst-forming unit-erythroid [BFU-E], CFU-granulocyte, erythroid, macrophage, megakaryocyte) progenitor cells and in stimulation of these progenitors to a higher cell cycling rate. This was associated with increased numbers of circulating neutrophils. Administration of IL-11 to mice pretreated with cyclophosphamide decreased the time required to regain normal levels of neutrophil and platelet counts in peripheral blood. In addition, IL-11 accelerated reconstitution to normal range of myeloid progenitors from bone marrow and spleen of myelosuppressed mice. These data suggest that IL-11 may play an important role in the regulation of hematopoiesis, and the application of this novel cytokine may have clinical therapeutic benefits.
Charge-Carrier Dynamics in 2D Hybrid Metal–Halide Perovskites (2016)

Hybrid metal-halide perovskites are promising new materials for use in solar cells; however, their chemical stability in the presence of moisture remains a significant drawback. Quasi two-dimensional (2D) perovskites that incorporate hydrophobic organic interlayers offer improved resistance to degradation by moisture, currently still at the cost of overall cell efficiency. To elucidate the factors affecting the optoelectronic properties of these materials, we have investigated the charge transport properties and crystallographic orientation of mixed methylammonium (MA)-phenylethylammonium (PEA) lead iodide thin films as a function of the MA-to-PEA ratio and, thus, the thickness of the "encapsulated" MA lead-halide layers. We find that monomolecular charge-carrier recombination rates first decrease with increasing PEA fraction, most likely as a result of trap passivation, but then increase significantly as excitonic effects begin to dominate for thin confined layers. Bimolecular and Auger recombination rate constants are found to be sensitive to changes in electronic confinement, which alters the density of states for electronic transitions. We demonstrate that effective charge-carrier mobilities remain remarkably high (near 10 cm<sup>2</sup>V<sup>-1</sup>s<sup>-1</sup>) for intermediate PEA content and are enhanced for preferential orientation of the conducting lead iodide layers along the probing electric field. The trade-off between trap reduction, electronic confinement, and layer orientation leads to calculated charge-carrier diffusion lengths reaching a maximum of 2.5 μm for intermediate PEA content (50%).
Electronic Tuning of Thiazolyl-Capped π-Conjugated Compounds via a Coordination/Cyclization Protocol with B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> (2010)

Electronic tuning of thiazolyl-capped π-conjugated systems via a coordination/cyclization protocol with B(C(6)F(5))(3) effectively enhances an electron-accepting character giving rise to lower reduction potentials and increases thermal stability.
A Robust Lane Detection and Verification Method for Intelligent Vehicles (2009)

Robust lane detection is important to the lane departure warning (LDW) for driver assistant system. In this study, lane marks are extracted by searching the lane model parameters in a special defined parameter space without thresholding. The proposed method is based on the lateral inhibition property of human vision system to clear up the edges of lane marks in variant weather conditions; moreover, the lane detected results are verified by the proposed conjugate Gaussian model such that there are no false alarm on the edges of shadow and other vehicles. The proposed lane detection method can gain precise lane-mark information for a lane departure warning system.
Insulin signaling to hepatic lipid metabolism in health and disease (2011)

The increasing prevalence of overnutrition and reduced activity has led to a worldwide epidemic of obesity. In many cases, this is associated with insulin resistance, an inability of the hormone to direct its physiological actions appropriately. A number of disease states accompany insulin resistance such as type 2 diabetes mellitus, the metabolic syndrome, and non-alcoholic fatty liver disease. Though the pathways by which insulin controls hepatic glucose output have been of intense study in recent years, considerably less attention has been devoted to how lipid metabolism is regulated. Thus, both the proximal signaling pathways as well as the more distal targets of insulin remain uncertain. In this review, we consider the signaling pathways by which insulin controls the synthesis and accumulation of lipids in the mammalian liver and, in particular, how this might lead to abnormal triglyceride deposition in liver during insulin-resistant states.
Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas (1995)

Evi-2, a common site of viral integration in BXH-2 myeloid lymphomas, is located within a large intron of the Nf1 tumor suppressor gene. Viral integration at Evi-2 appears to induce disease by disrupting normal Nf1 expression. During our attempts to characterize the nature of the proviruses located at Evi-2, we found that approximately half of the proviruses were defective nonecotropic proviruses (A. M. Buchberg, H. G. Bedigian, N. A. Jenkins, and N. G. Copeland, Mol. Cell. Biol. 10:4658-4666, 1990). This was surprising, since most proviruses characterized at other BXH-2 common integration sites are full-length ecotropic viruses. In the studies described here, we found that this defective provirus carries two large deletions, one in pol and one in env, and is structurally related to another murine retrovirus, the murine AIDS retrovirus. By using oligonucleotide probes specific for this defective provirus, designated MRV, we showed that MRV-related proviruses are carried as endogenous germ line proviruses in most inbred strains. In addition, we identified the endogenous MRV provirus that gives rise to the defective proviruses identified at Evi-2. We present a model that accounts for the positive selection of MRV proviruses at Evi-2, which may allow selective identification of common viral integration sites harboring tumor suppressor genes.
Types of nuclear endonuclease activity capable of inducing internucleosomal DNA fragmentation are completely different between human CD34+ cells and their granulocytic descendants (1995)

A hallmark of apoptosis is internucleosomal DNA fragmentation resulting from the activation of endonucleases. We characterized the endonuclease activity of human myeloid cell nuclei that cleaved their own nuclear chromatin to oligonucleosomal length fragments. Polymorphonuclear leukocytes (PMNs) of normal peripheral blood contained both Ca2+/Mg(2+)- dependent and DNase II-like acidic endonuclease activities in their nuclei. Immature myeloid cells of normal bone marrow at various stages of granulocytic maturation had similar nuclease activities. In contrast, a clear difference was shown in the circulating CD34+ cells, in that only Mg(2+)-dependent, Ca(2+)-independent endonuclease activity was detected. Consistent with these findings is the emergence of the Ca2+/Mg(2+)-dependent and acidic endonuclease concomitantly with the disappearance of the Mg(2+)-dependent endonuclease when CD34+ cells were induced to differentiate in vitro toward granulocytes. Leukemic cell lines of all lineages also had Mg(2+)-dependent nuclease activity. Our results suggest an association of the Mg(2+)-dependent endonuclease with hematopoietic progenitor cells and that the relative activities of the nuclear nuclease in human myeloid cells change substantially during granulocytic differentiation.
Nuclear texture parameters as discriminant factors in cell cycle and drug sensitivity studies (1991)

The authors have recently shown that cell cycle characteristics of in situ cell populations can be determined using the SAMBA 200 cell image processor by computing 15 densitometric and texture parameters on each Feulgen-stained nucleus and multiparametric analysis of data. The present paper displays the importance of chromatin pattern assessment and detection of conformational changes in DNA structure, based on nine nuclear texture parameters measured from the grey level cooccurrence and the run-length section matrices. Reference files were constructed by merging respective reference files (G0/G1, S, G2 and M) of MDA AG and MCF-7, two mammary epithelial cell lines presenting different morphological aspects and hormone responses, these files were found to be valid in the reclassification of any mammary epithelial cell in culture with a diploid or near diploid pattern. Moreover, the authors demonstrate that chromatin texture changes, following direct interaction of chemotherapeutic drugs with DNA, may be assessed owing to nuclear texture parameters. Consecutive to daunomycin addition (0.5 microgram/ml) and concomitant to the appearance of nuclear morphological alterations in MDA AG sensitive cells as viewed by microscopic observation, discriminant factorial analysis showed progressively increasing erroneous reclassification from 15 to 72 h of treatment. These experimental results were exploited with a kinetic mathematical model to quantify the daunomycin blocking effect: 20% in S phase and 80% in G2 phase. Interestingly, no textural change was observed on MDA A1 anthracycline resistant cells, indicating that these texture parameters may permit distinction of drug sensitive cells. This methodology 1) can be applied to test in vitro resistance-reversal molecules, 2) may be extended to other therapeutic agents giving rise to conformational changes in DNA structure, and 3) can be applied to cytopunctions or imprints of tumor biopsies with diploid-like DNA content to follow evolution of drug sensitivity or resistance during course of therapy.
Initial Description of the Presumed Congenital Zika Syndrome (2016)

Affected nations need to prepare to provide complex and costly multidisciplinary care that children diagnosed with this new congenital syndrome will require.
Intense Infrared Luminescence in Transparent Glass-Ceramics Containing β-Ga<sub>2</sub>O<sub>3</sub>:Ni<sup>2+</sup> Nanocrystals (2007)

Transparent glass-ceramics containing β-Ga2O3:Ni2+ nanocrystals were synthesized and characterized by X-ray diffraction, transmission electron microscopy, and electron energy loss spectroscopy. Intense broad-band luminescence centering at 1200 nm was observed when the sample was excited by a diode laser at 980 nm. The room-temperature fluorescent lifetime was 665 μs, which is longer than the Ni2+-doped ZnAl2O4 and LiGa5O8 glass-ceramics and is also comparable to the Ni2+-doped LiGa5O8 single crystal. The intense infrared luminescence with long fluorescent lifetime may be ascribed to the high crystal field hold by Ni2+ and the moderate lattice phonon energy of β-Ga2O3. The excellent optical properties of this novel material indicate that it might be a promising candidate for broad-band amplifiers and room-temperature tunable lasers.
Demonstration of 1.27 kV Etch-Then-Regrow GaN ${p}$ -${n}$ Junctions With Low Leakage for GaN Power Electronics (2019)

This letter reports high performance GaN p-n junctions with regrown p-GaN by metalorganic chemical vapor deposition (MOCVD) on dry-etched surfaces. The breakdown voltage reaches 1.27 kV and the differential on-resistance is 0.8 m · cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The effects of etching powers and surface treatments on the reverse leakage characteristics of the regrown p-n junctions have been investigated. It's found that lowering the etching power and damage is very effective to reduce the leakage currents and increase the breakdown voltages. Further analysis reveals that the charge concentration at the regrowth interface plays a critical role in the performance of the regrown samples. To avoid sacrificing the etching rate by using only low power etching, a multiple-RF-power etching recipe was developed with gradually decreased etching power. This work has demonstrated a practical and viable method to realize high performance regrown p-n junctions for various advanced GaN power electronics.
Non-Functional Requirements for Distributable User Interfaces in Agile Processes (2014)

This paper presents a two-folded approach to deal with non-functional requirements for distributable user interfaces (DeUIs) in agile processes. This proposal employs a conceptual agile framework that ensures earlier consideration of nonfunctional requirements and stakeholders' involvement to solve tensions among agility, requirements engineering practices and continuous system architecture adaptation. Besides, it improves the step of continuous architecture adaptation as established in the DeUI field by employing model-driven architectures. Thus, while this approach profits from the conceptual framework by means of continuous feedback on how to technically better support the classical tension between agility and requirement engineering; it also takes advantage of model-driven architecture to cope with the tension between agility and distributable user interface architecture changes.
Residual Avid in Activity in Cooked Egg White Assayed with Improved Sensitivity (1991)

ABSTRACT An assay, based on binding of the dye 2–(4'hydroxyazobenzene)‐benzoic acid (HABA) and widely used in studies of avidin in liquid systems, was combined with an aqueous extraction method and used to assay avidin in cooked egg white. The method was validated for linearity of response to increasing avidin concentrations, precision, accuracy, recovery and sensitivity. Mean residual avidin activity in fried, poached and boiled (2 min) egg white was 33, 71 and 40% of the activity in raw egg white.
现代科学的诞生：文化、思想及科学创新 (2007)

按照吕克·福彻尔等人的观点，“中国”和“东亚”与“古希腊”和“美国”相比，在理解世界的方式上存在颇大文化差异。福彻尔等人支持理查德·尼斯贝特的观点，宣称数学科学的诞生得益于“希腊”或“西方”的偏好分析、抽象及理性推理的文化范式；反对阿里森·高普尼克持现代科学的发展受文艺复兴后期人们对休闲和信息追求所驱动的观点；认为“中国”和“东亚”的文化范式强调整体性，是具体而辩证的。福彻尔等人以尼斯贝特及其同事们的心理学研究成果等为立论的依据是不能成立的；因为尼斯贝特等人的心理学研究成果与现代科学的诞生毫无关系；“李约瑟难题”，即现代科学的诞生为何源于欧洲而非世界其他地方的问题，本身就非常含糊不清，根本没有任何质疑的价值。
Clinical Evaluation of the Small-Pupil Binocular Indirect Ophthalmoscope (1969)

A description and clinical evaluation of the small-pupil binocular indirect ophthalmoscope is presented. This instrument can be used as an ordinary indirect stereoscopic ophthalmoscope. In addition, it performs better than available instruments in different situations, for instance when the patient's pupil is small (down to 1.5 mm) or partly occupied by opacities, or for the examination of the extreme fundus periphery with any kind of pupil. The principles of construction of the instrument are briefly outlined. This is followed by a description of the recommended technique and a description of clinical situations in which the instrument has been found of advantage.
Refining buffer overflow detection via demand-driven path-sensitive analysis (2007)

Although static analysis is an important technique for detecting buffer overflow before software deployment, current static tools rely on considerable human effort for annotating code to help analysis, or for diagnosing warnings, many of which are false positives. This paper presents an analysis technique that refines information about the paths that involve a potential buffer overflow to help in the diagnosis and debugging of vulnerabilities. Instead of only reporting a vulnerable buffer or statement in the program, which most tools do, our analysis categorizes paths of a possibly vulnerable statement into five types: Vulnerable, Overflow-User-Independent, Safe, Infeasible and Don't-Know. Thus, safe and infeasible paths can be excluded from being inspected, providing focus on problematic paths. For scalability, we designed and implemented our analysis as an interprocedural, demand-driven path-sensitive analysis. Our experiments demonstrate that various path types do go through a possibly vulnerable buffer statement. The results also indicate that our technique is efficient and practical.
Penicillin‐binding protein 2a of methicillin‐resistant <i>Staphylococcus aureus</i> (2014)

High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of the challenge by β-lactam antibiotics. The activity of this protein is regulated by allostery at a site 60 Å distant from the active site, where crosslinking of cell wall takes place. This review discusses the state of knowledge on this important enzyme of cell-wall biosynthesis in MRSA.
Flow injection cytoanalysis (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlow injection cytoanalysisJaromir Ruzicka and Walter LindbergCite this: Anal. Chem. 1992, 64, 9, 537A–545APublication Date (Print):May 1, 1992Publication History Published online22 September 2008Published inissue 1 May 1992https://doi.org/10.1021/ac00033a002RIGHTS & PERMISSIONSArticle Views80Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (9 MB) Get e-Alerts Get e-Alerts
Isolated flyback-current-fed push-pull converter for power factor correction (2002)

This paper presents a single-stage high-power factor isolated power supply based on the classical flyback-current-fed push-pull converter. The proposed converter operates as a buck one at a duty-cycle below 50% and as a boost one at duty-cycle above this range. Therefore, when properly driven, this converter is suitable for high power factor applications, with many advantages when compared with the boost-isolated current-fed converter, including inrush current control and less voltage stress over the power semiconductors. Theoretical analysis, design methodology, design example, control strategy, and experimental results are presented is paper.
ActionXPose: A Novel 2D Multi-view Pose-based Algorithm for Real-time Human Action Recognition (2018)

We present ActionXPose, a novel 2D pose-based algorithm for posture-level Human Action Recognition (HAR). The proposed approach exploits 2D human poses provided by OpenPose detector from RGB videos. ActionXPose aims to process poses data to be provided to a Long Short-Term Memory Neural Network and to a 1D Convolutional Neural Network, which solve the classification problem. ActionXPose is one of the first algorithms that exploits 2D human poses for HAR. The algorithm has real-time performance and it is robust to camera movings, subject proximity changes, viewpoint changes, subject appearance changes and provide high generalization degree. In fact, extensive simulations show that ActionXPose can be successfully trained using different datasets at once. State-of-the-art performance on popular datasets for posture-related HAR problems (i3DPost, KTH) are provided and results are compared with those obtained by other methods, including the selected ActionXPose baseline. Moreover, we also proposed two novel datasets called MPOSE and ISLD recorded in our Intelligent Sensing Lab, to show ActionXPose generalization performance.
ELECTROMYOGRAPHIC COMPARISON OF THE AB-SLIDE AND CRUNCH EXERCISES (2006)

The purpose of this study was to compare the Ab-Slide with crunch abdominal exercises for electromyographic activity for selected muscles. Forty-five subjects who regularly performed abdominal exercises participated. Subjects completed 5 trials for each exercise, with repetition rate controlled by the tester. Electromyographic activity for the external oblique (EO), upper rectus abdominis (URA), and lower rectus abdominis (LRA) was collected. Raw data for each muscle were rectified and integrated over 100-millisecond time intervals. For each muscle, the average concentric and eccentric integrated amplitudes of the middle 3 trials were compared with a dependent t-test. During concentric movement, the EO and LRA had significantly higher integrated activation amplitudes for the crunch exercise. During the eccentric movement, the URA, LRA, and EO had significantly higher average integrated activation amplitudes for the Ab-Slide exercise. The Ab-Slide is a credible abdominal exercise variation, but the crunch should remain the standard abdominal exercise.
Properties of coatings based on Cr, Ti, and Mo nitrides with embedded metals deposited on cutting tools (2011)

The relation between the phase-structure state and mechanical and operating characteristics of coatings based on solid solutions of (Ti, Cr)N, (Ti, Mo)N with Cr and Mo formed on a hard tool T15K6 alloy by condensation and ion bombardment of combined plasma flows in nitrogen is studied. A tool with the coating based on the solid solution (Ti, Cr)N is shown to have high hardness, low friction coefficient, and maximal resistance to cracking and oxidation, resulting in increased service life in mechanical working of steel.
Translocation of β-Galactosidase Mediated by the Cell-Penetrating Peptide Pep-1 into Lipid Vesicles and Human HeLa Cells Is Driven by Membrane Electrostatic Potential (2005)

The cell-penetrating peptide (CPP) pep-1 is capable of introducing large proteins into different cell lines, maintaining their biological activity. Two possible mechanisms have been proposed to explain the entrance of other CPPs in cells, endosomal-dependent and independent types. In this work, we evaluated the molecular mechanisms of pep-1-mediated cellular uptake of beta-galactosidase (beta-Gal) from Escherichia coli in large unilamellar vesicles (LUV) and HeLa cells. Fluorescence spectroscopy was used to evaluate the translocation process in model systems (LUV). Immunofluorescence microscopy was used to study the translocation in HeLa cells. Enzymatic activity detection enabled us to monitor the internalization of beta-Gal into LUV and the functionality of the protein in the interior of HeLa cells. Beta-Gal translocated into LUV in a transmembrane potential-dependent manner. Likewise, the extent of beta-Gal incorporation was extensively decreased in depolarized cells. Furthermore, beta-Gal uptake efficiency and kinetics were temperature-independent, and beta-Gal did not colocalize with endosomes, lysosomes, or caveosomes. Therefore, beta-Gal translocation was not associated with the endosomal pathway. Although an excess of pep-1 was mandatory for beta-Gal translocation in vivo, transmembrane pores were not formed as concluded from the trypan blue exclusion method. These results altogether indicated that protein uptake both in vitro with LUV and in vivo with HeLa cells was mainly, if not solely, dependent on negative transmembrane potential across the bilayer, which suggests a physical mechanism governed by electrostatic interactions between pep-1 (positively charged) and membranes (negatively charged).