gebhart/patrepeval huggingface dataset:
Hypocholesterolemic Effect of Hot-Water Extract from Mycelia of Cordyceps sinensis. (2003)

This study was conducted to investigate the hypocholesterolemic effect of the hot-water fraction (HW) from cultured mycelia of Cordyceps sinensis in a 5 l fermenter. The composition of HW was mainly carbohydrate (83.9%) and protein (11.8%) on a dry basis, and the carbohydrate of HW consisted of glucose, mannose, galactose, and arabinose in the molecular ratio of 1.0 : 0.8 : 0.5 : 0.1, respectively. In mice fed a cholesterol-free diet and those fed a cholesterol-enriched diet, body and liver weights were not significantly different from those of the controls. The serum total cholesterol (TC) of all mice groups administered HW (150 and 300 mg/kg/d, respectively) with the cholesterol-enriched diet decreased more than in the control group. Among the mice fed the cholesterol-enriched diet, HW also increased the high-density lipoprotein (HDL) cholesterol level, but decreased the very low-density lipoprotein plus low-density lipoprotein (VLDL+LDL) cholesterol level. The changes in HDL- and VLDL+LDL-cholesterol levels consequently decreased the atherogenic value. The results indicate that HW in rats administered a cholesterol-enriched diet decreased the plasma cholesterol level. The 300 mg/kg dose had a significant effect on the serum TC level.
ChemInform Abstract: Developments in Nonsteroidal Antiandrogens Targeting the Androgen Receptor (2010)

Abstract Review: ca. 100 refs.
Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) production during murine endotoxaemia (1996)

IL-10 is an endogenous antiinflammatory cytokine that inhibits TNF biosynthesis and protects mice from lipopolysaccharide (LPS)-induced lethality. As synthetic glucocorticoids are widely used as antiinflammatory agents, we analysed the effects of methylprednisolone administration on IL-10 biosynthesis during murine endotoxaemia. We found that low doses of methylprednisolone (2-10 mg/kg) markedly inhibited TNF production but did not affect serum levels of IL-10, while a high methylprednisolone dose (50 mg/kg) increased LPS-induced IL-10 levels. In parallel, we observed that LPS-induced IL-10 production is TNF-independent in this experimental setting. Experiments conducted in vitro indicated that methylprednisolone (from 0.01 to 100 micrograms/ml) also increased the biosynthesis of IL-10 by LPS-activated mouse peritoneal macrophages. We conclude that methylprednisolone differentially regulates IL-10 and TNF production induced by LPS both in vivo and in vitro at the macrophage level.
The energetic balance of the friction clutches used in automotive (2011)

The energetic transfer through the friction clutch is accompanied by dissipative processes. The causes that produce these processes are the friction from the plate package. The dissipative restrictions that are independent of the temperature gradient or the direction of the heat flux present in the clutch's mass are imposed by the maximum temperatures admitted by the friction materials, by the electrically insulating materials and the lubricant (if it takes place in a wet environment).
Fast events in single‐channel currents activated by acetylcholine and its analogues at the frog muscle end‐plate. (1985)

The fine structure of ion-channel activations by junctional nicotinic receptors in adult frog muscle fibres has been investigated. The agonists used were acetylcholine (ACh), carbachol (CCh), suberyldicholine (SubCh) and decan-1,10-dicarboxylic acid dicholine ester (DecCh). Individual activations (bursts) were interrupted by short closed periods; the distribution of their durations showed a major fast component ('short gaps') and a minor slower component ('intermediate gaps'). The mean duration of both short and intermediate gaps was dependent on the nature of the agonist. For short gaps the mean durations (microseconds) were: ACh, 20; SubCh, 43; DecCh, 71; CCh, 13. The mean number of short gaps per burst were: ACh, 1.9; SubCh, 4.1; DecCh, 2.0. The mean number of short gaps per burst, and the mean number per unit open time, were dependent on the nature of the agonist, but showed little dependence on agonist concentration or membrane potential for ACh, SubCh and DecCh. The short gaps in CCh increased in frequency with agonist concentration and were mainly produced by channel blockages by CCh itself. Partially open channels (subconductance states) were clearly resolved rarely (0.4% of gaps within bursts) but regularly. Conductances of 18% (most commonly) and 71% of the main value were found. However, most short gaps were probably full closures. The distribution of burst lengths had two components. The faster component represented mainly isolated short openings that were much more common at low agonist concentrations. The slower component represented bursts of longer openings. Except at very low concentrations more than 85% of activations were of this type, which corresponds to the 'channel lifetime' found by noise analysis. The frequency of channel openings increased slightly with hyperpolarization. The short gaps during activations were little affected when (a) the [H+]o or [Ca2+]o were reduced to 1/10th of normal, (b) when extracellular Ca2+ was replaced by Mg2+, (c) when the [Cl-]i was raised or (d) when, in one experiment on an isolated inside-out patch, the normal intracellular constituents were replaced by KCl. Reduction of [Ca2+]O to 1/10 of normal increased the single-channel conductance by 50%, and considerably increased the number of intermediate gaps. No temporal asymmetry was detectable in the bursts of openings. Positive correlations were found between the lengths of successive apparent open times at low SubCh concentrations, but no correlations between burst lengths were detectable. The component of brief openings behaves, at low concentrations, as though it originates from openings of singly occupied channels.(ABSTRACT TRUNCATED AT 400 WORDS)
Cross-layer design in 4G wireless terminals (2004)

The classical TCP/IP layered protocol archi- tecture is beginning to show signs of age. In order to cope with problems such as the poor performance of wireless links and mobile termi- nals, including the high error rate of wireless network interfaces, power saving requirements, quality of service, and an increasingly dynamic network environment, a protocol architecture that considers cross-layer interactions seems to be required. This article describes a framework for further enhancements of the traditional IP- based protocol stack to meet current and future requirements. Known problems associated with the strictly layered protocol architecture are summarized and classified, and a first solution involving cross-layer design is proposed.
Mevalonate Biosynthesis in Plants (1999)

(1999). Mevalonate Biosynthesis in Plants. Critical Reviews in Biochemistry and Molecular Biology: Vol. 34, No. 2, pp. 107-122.
Extemporaneous sildenafil citrate oral suspensions for the treatment of pulmonary hypertension in children (2006)

Sildenafil citrate 2.5 mg/mL in two extemporaneously compounded oral suspensions was stable for 91 days in plastic prescription bottles at 4 and 25 degrees C.
The PathStar access server: Facilitating carrier-scale packet telephony (1998)

The maturation of large-scale Internet protocol (IP) routing and the standardization of voice over IP (VoIP) protocols have accelerated the deployment of packet telephony products in the public network. Service providers such as the Regional Bell Operating Companies, competitive local exchange carriers, multiple system operators, and Internet service providers (ISPs) are beginning to seek out next-generation products to consolidate voice, video, and data onto converged packet-based networks. To address this market, Lucent Technologies has developed and introduced a suite of data networking and packet telephony products, one of which is the PathStar Access Server. This revolutionary new product integrates Bell Labs software innovations such as the Inferno® operating system with access and interconnection technologies developed by the Switching, Access, and Data Networking areas of Lucent Technologies. The PathStar Access Server combines the functionality and features of traditional circuit switches with advanced packet routing techniques to enable end-to-end converged network solutions. This paper presents an overview of the PathStar Access Server and briefly explores its hardware and software architectures.
Effective, High-Yielding, and Stereospecific Total Synthesis of <scp>d</scp>-<i>e</i><i>rythro</i>-(2<i>R</i>,3<i>S</i>)-Sphingosine from <scp>d</scp>-<i>r</i><i>ibo</i>-(2<i>S</i>,3<i>S</i>,4<i>R</i>)-Phytosphingosine (2004)

The synthesis of naturally occurring D-erythro-(2R,3S,4E)-sphingosine from commercially available D-ribo-(2S,3S,4R)-phytosphingosine is described. The key step in the reaction sequence comprises TMSI/DBN promoted regio- and stereoselective oxirane opening of intermediate 2-phenyl-4-(S)-[(1S,2S)-1,2-epoxyhexadecyl]-1,3-oxazoline followed by the in situ trans-elimination of 2-phenyl-4-(S)-[(1S,2R)-1,2-dideoxy-2-iodo-1-trimethylsilyloxyhexadecyl]-1,3-oxazoline.
Two distinct cDNAs for human IMP dehydrogenase. (1990)

IMP dehydrogenase (EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, is a promising target in antileukemic chemotherapy. We have isolated two distinct cDNA clones (types I and II) encoding IMP dehydrogenase from a human spleen cDNA library. Both clones encode closely related proteins of 514 residues showing 84% sequence identity. Northern hybridization analyses of poly(A)+ RNA from human normal leukocytes and human ovarian tumors demonstrated a striking contrast in mRNA expression in that type I mRNA is the main species in normal leukocytes and type II predominates over type I in the tumor. This is the first report suggesting the existence of two distinct types of human IMP dehydrogenase molecular species which may have different sensitivities to the drugs targeted against IMP dehydrogenase.
In Memoriam: William Cash (1918)

ILLIAM CASH was born in Leeds in April 1843.He migrated to Halifax as a boy and entered the service of the Halifax and Huddersfield Union Bank, becoming eventually a manager.He took much interest in public life, and in 1889 was Chairman of the Halifax School Board at the time that his friend, J. W. Davis, was Mayor of the town, so that the rising Halifax was pretty fully penetrated with modern ideas of the proper position of science in the community.About 1893, Mr. Cash severed his connection with the bank and established himself in business as an accountant.
Temperature Sensitivity of Bubble Domains (1972)

The temperature sensitivities of bubble domains in the mixed rare-earth orthoferrites and the uniaxial magnetic garnets are derived in terms of the material parameters. For the garnets, there exists an optimum plate thickness of 6lM to minimize the sensitivity, although this minimum is fairly flat from 4lM to 10lM. For the orthoferrites, it is preferable to use as thick a plate as possible subject to other constraints.
Matrix Metalloproteinase Levels in Children With Aggressive Periodontitis (2008)

MMP levels were elevated in AgP sites relative to non-diseased sites in the same subjects, in siblings, and in unrelated controls. MMPs associated with the AgP sites in children were generally elevated compared to an adult cohort with a history of CP.
Humoral and cellular immune reactions 'in vitro' against allogeneic and autologous human melanoma cells. (1975)

Based on 51Cr release from an allogeneic human melanoma cell (M1) cell-mediated (CMC) and antibody-dependent cellular cytotoxicity (ADCC) were determined in twenty-eight melanoma patients, thirty-one healthy controls, ten patients with other tumours and eleven chronic lymphocytic leukaemia (CLL) patients. The results were related to simultaneously performed microcytotoxicity (MC) tests, HL-A typing, plasma membrane fluorescence and B:T cell ratios in the peripheral blood. Furthermore, lymphocytes from six melanoma patients were tested in CMC and ADCC assays against autologous tumour cells. The following results were obtained. (1) A large number of healthy controls possessed lymphocytes which readily lysed M1 target cells in CMC and MC assays. (2) CMC activity of lymphocytes from melanoma patients was generally lower than that of control lymphocytes and decreased further with progression of the disease. (3) CLL lymphocytes were virtually non-toxic for M1 cells, even at high aggressor:target cell ratios. (4) ADCC assays with a heterologous rabbit-anti-M1 serum showed generally higher isotope release than CMC assays; this was particularly pronounced in the melanoma group and in the group of patients with other tumours. (5) No tumour-specific blocking factor could be detected in melanoma sera, as judged by the capacity of the sera to block CMC activity. (6) No obvious correlation was found between the results obtained in short-term CMC and long-term MC assays. (7) T lymphocytes, as determined by E-rosette formation, were significantly diminished in melanoma patients. (8) The HL-A type of lymphocytes from normal donors and melanoma patients did not appear to be related to high or low activity in CMC and MC assays. (9) Preliminary results of 51Cr release tests with autologous melanoma cells were encouraging with respect to the correlation of the results to the clinical course of the disease.
Polyimide Passivated AlGaN–GaN HFETs With 7.65 W/mm at 18 GHz (2004)

Current metal-organic chemical vapor deposition-grown AlGaN-GaN heterojunction field-effect transistor devices suffer from threading dislocations and surface states that form traps, degrading RF performance. A passivation scheme utilizing a polyimide film as the passivating layer was developed to reduce the number of surface states and minimize RF dispersion. Continuous-wave power measurements were taken at 18 GHz on two-finger 0.23-μm devices with 2×75 μm total gate width before and after passivation yielding an increase from 2.14 W/mm to 4.02 W/mm in power density, and 12.5% to 24.47% in power added efficiency. Additionally, a 2×25 μm device yielded a peak power density of 7.65 W/mm at 18 GHz. This data suggests that polyimide can be an effective passivation film for reducing surface states.
Tumor Specific Delivery and Therapy by Double-Targeted Nanostructured Lipid Carriers with Anti-VEGFR-2 Antibody (2011)

Vascular endothelial growth factor receptors (VEGFRs) are overexpressed on the surface of a variety of tumor cells and on tumor neovasculature in situ, which are potential targets for "double targeting" (tumor- and vascular-targeting) tumor therapy. This study aimed to develop a VEGFR-mediated drug delivery system to target chemotherapeutic agents to VEGFR-overexpressed tumor cells and tumor neovasculature endothelial cells in vitro and in vivo. An antibody modified docetaxel (DTX)-loaded targeted nanostructured lipid carrier (tNLC) was designed and prepared with DSPE-PEG-NH(2) as linker. The cellular cytotoxicity, cellular uptake, in vivo therapeutic effect and biodistribution of tNLC were investigated. The tNLC showed a particle size about 168 nm with encapsulation efficiency >95%, drug loading 5.55 ± 0.06% (w/w) and an average ligand coupling efficiency of 3.34 ± 2.63%. Cytotoxicity of tNLC against three human cell lines and one murine malignant melanoma was superior to that of Duopafei and nontargeted NLC (nNLC). The tNLC also showed better tolerance and antitumor efficacy in a murine model bearing B16 compared with Duopafei or nNLC. The studies on cellular uptake and biodistribution indicated that the better antitumor efficacy of tNLC was attributed to the increased accumulation of drug in both tumor and tumor vasculature. These findings suggested that tNLC designed to bind specifically to VEGFR-2 can be used to deliver DTX to the tumor vasculature and tumor and may inhibit tumor growth.
A highly specific metal-activated catalytic antibody (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA highly specific metal-activated catalytic antibodyWarren S. Wade, Jon A. Ashley, Guiti K. Jahangiri, Gregory McElhaney, Kim D. Janda, and Richard A. LernerCite this: J. Am. Chem. Soc. 1993, 115, 11, 4906–4907Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/ja00064a068https://doi.org/10.1021/ja00064a068research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Kerberos plus RSA for world wide web security (1995)

We show how to use Kerberos to enable its clients to interact securely with non-Kerberized World Wide Web servers. That is, our protocol does not require that the Web server be a member of a Kerberos realm, and also does not rely on time-synchronization between the participants. In our protocol, the Kerberos client uses the Web server&apos;s public-key certificate to gain cryptographic credentials that conform to public-key authentication standards, and to SHTTP. The client does not perform any publickey encryptions. Further, the client is well-protected from a man-in-the-middle attack that weakens SSL. Our protocol conforms to the current specifications for the Kerberos protocol and for the Secure Hypertext Transfer Protocol. 1 Introduction The effort to secure the World-Wide Web for electronic commerce brings to a sharp focus the difficulties that have prevented the Internet from adopting a single coherent security model. On the one hand, like the Internet, the Web as a whole is too big...
Effect of Molecular Weight of Surfactant in Nano Ceria Slurry on Shallow Trench Isolation Chemical Mechanical Polishing (CMP) (2004)

We examined the effect of the molecular weight of surfactants in ceria slurry during chemical mechanical polishing (CMP) for shallow trench isolation (STI). We found that for a surfactant with a higher molecular weight, the oxide removal rate decreased drastically as the surfactant concentration increased, but in the case of a lower molecular weight, it only slightly decreased. In addition, slurries whose surfactants had lower molecular weights maintained a higher nitride removal rate with increasing surfactant concentration. The results showed that the molecular weight and surfactant concentration have complex effects on the oxide removal rate and the oxide-to-nitride removal selectivity.
Predicting Days in Hospital Using Health Insurance Claims (2015)

Health-care administrators worldwide are striving to lower the cost of care while improving the quality of care given. Hospitalization is the largest component of health expenditure. Therefore, earlier identification of those at higher risk of being hospitalized would help health-care administrators and health insurers to develop better plans and strategies. In this paper, a method was developed, using large-scale health insurance claims data, to predict the number of hospitalization days in a population. We utilized a regression decision tree algorithm, along with insurance claim data from 242 075 individuals over three years, to provide predictions of number of days in hospital in the third year, based on hospital admissions and procedure claims data. The proposed method performs well in the general population as well as in subpopulations. Results indicate that the proposed model significantly improves predictions over two established baseline methods (predicting a constant number of days for each customer and using the number of days in hospital of the previous year as the forecast for the following year). A reasonable predictive accuracy (AUC =0.843) was achieved for the whole population. Analysis of two subpopulations-namely elderly persons aged 63 years or older in 2011 and patients hospitalized for at least one day in the previous year-revealed that the medical information (e.g., diagnosis codes) contributed more to predictions for these two subpopulations, in comparison to the population as a whole.
Noise radar using random phase and frequency modulation (2004)

Pulse compression radar is used in a great number of applications. Excellent range resolution and high electronic counter-countermeasures performance is achieved by wideband long pulses, which spread out the transmitted energy in frequency and time. By using a random noise waveform, the range ambiguity is suppressed as well. In most applications, the random signal is transmitted directly from a noise-generating microwave source. A sine wave, which is phase or frequency modulated by random noise, is an alternative, and in this paper, the ambiguity function and the statistical characteristics of the correlation output for the latter configuration are further analyzed. Range resolution is then improved because the noise bandwidth of the modulated carrier is wider than that of the modulating signal, and the range sidelobes are also further suppressed. Random biphase modulation gives a 4-dB (/spl pi//sup 2//4) improvement, but much higher sidelobe suppression could be achieved using continuous phase/frequency modulation. Due to the randomness of the waveform, the output correlation integral is accompanied by a noise floor, which limits the possible sidelobe suppression as determined by the time-bandwidth product. In synthetic aperture radar (SAR) applications with distributed targets, this product should be large compared with the number of resolution elements inside the antenna main beam. The advantages of low range sidelobes and enhanced range resolution make frequency/phase-modulated noise radar attractive for many applications, including SAR mapping, surveillance, altimetry, and scatterometry. Computer algorithms for reference signal delay and compression are discussed as replacements for the classical delay line implementation.
Neutron Sensitive Electron Multiplier Tubes (1956)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation G. F. Erickson, S. G. Kaufmann; Neutron Sensitive Electron Multiplier Tubes. Rev. Sci. Instrum. 1 February 1956; 27 (2): 107–108. https://doi.org/10.1063/1.1715474 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioReview of Scientific Instruments Search Advanced Search |Citation Search