gebhart/patrepeval huggingface dataset:
The Inexact Science of Risk Assessment (and Implications for Risk Management) (1998)

Human health risk estimates are calculated for use in setting standards, cleanup levels for hazardous wastes, or otherwise expressing an exposure level that is believed to be safe or associated with some risk. Most risk estimates are calculated to be protective of human health, rather than predictive of actual toxicity. For example, cancer potency factors calculated by the U.S. EPA are presented as the 95% upper confidence limit on the dose-response curve, rather than the maximum likelihood estimate. EPA goes on to say that risk assessors believe the actual cancer risk to be somewhere below this upper confidence limit, and that it could be as low as zero. This is an acknowledgm ment of the uncertainty inherent in the process of cancer risk assessment, which is a function of both cross-species and high-to-low dose extrapolation. Similarly, for noncancer risk assessments, U.S. EPA (1995) calculates Reference Doses (RfDs) and Reference Concentrations (RfCs) , which are defined as: ...an estimate (with uncertainty spanningperhaps an order ofmagnitude) ofa daily or continuous exposure... The values generated by the process of risk assessment are imprecise; such imprecision is clearly articulated by the definitions provided. Somewhere between the steps of risk assessment and risk management, however, the concept of risk estimates as inherently imprecise has been lost. This is probably due to a number of reasons, one of which is likely because the risk manager has to communicate with a public that wants to know with some certainty and precision what the risks from exposure to hazardous substances actually are (and in rather succinct terms), rather than hearing the risks described more appropriately as scientific judgments that are, by their very
<i>Neural Cache</i>: Bit-Serial In-Cache Acceleration of Deep Neural Networks (2019)

This article presents Neural Cache architecture, which repurposes cache structures to transform them into massively parallel compute units capable of running inferences for deep neural networks. Techniques to do in situ arithmetic in SRAM arrays create efficient data mapping, and reducing data movement is proposed. Neural Cache architecture is capable of fully executing convolutional, fully connected, and pooling layers in cache. Our experimental results show that the proposed architecture can improve efficiency over a GPU by $\mathbf {128\times}$128× while requiring a minimal area overhead of 2%.
A method to generate soft shadows using a layered depth image and warping (2005)

We present an image-based method for propagating area light illumination through a Layered Depth Image (LDI) to generate soft shadows from opaque and nonrefractive transparent objects. In our approach, using the depth peeling technique, we render an LDI from a reference light sample on a planar light source. Light illumination of all pixels in an LDI is then determined for all the other sample points via warping, an image-based rendering technique, which approximates ray tracing in our method. We use an image-warping equation and McMillan's warp ordering algorithm to find the intersections between rays and polygons and to find the order of intersections. Experiments for opaque and nonrefractive transparent objects are presented. Results indicate our approach generates soft shadows fast and effectively. Advantages and disadvantages of the proposed method are also discussed.
Precise Simulation of Spectrum for Green Emitting Phosphors Pumped by a Blue LED Die (2014)

This paper proposes an effective approach for spectrum shaping in the optical modeling of phosphor-converted white light-emitting diodes (LEDs) in which overlapping of the absorption and emission spectra of the phosphor are considered. The spectrum shaping method was applied to explore the wavelength-dependent absorption effect and reabsorption by the green phosphor. The experimental results indicated that the adjustment factor for blue light can enable the blue light spectrum to fit well with the measured spectrum. The adjustment factor was linearly related to the transmission ratio of the blue light. The blue light emitted by the blue die and the green light emitted by the phosphor were simulated and predicted in an accurate way as compared with the experimental measurements. The enhanced accuracy in assessing the spectra resulted in enhanced precision of chromaticities. In the experiments, the color differences were one order smaller in CIE 1931 chromaticity (Δx, Δy) than in models without spectrum shaping and were almost imperceptible to the human eye. The novel optical modeling of green phosphor pumped by a blue die facilitates the application of these materials in high-color rendering in white LEDs and projection displays.
[The effect of procyanidolic oligomers on vascular permeability. A study using quantitative morphology]. (1990)

In normal conditions vascular permeability is precisely regulated by mechanisms which involve among others the macromolecules of extracellular matrix of the vascular wall. Permeability for a given substance will vary according to the anatomical localisation of the vessel determining also its structure and composition. In some pathological conditions, such as inflammation or diabetes, permeability can be abnormally increased. Increased permeability can be reproduced by i.v. collagenase injection. This permeability increase can be quantified by image analysis using appropriate tracers such as FITC-dextrans or horse-radish peroxidase, on histological sections from control and collagenase treated rats, pretreated or not with procyanidolic oligomers (PCO). We studied cerebral capillaries, aorta and cardiac muscle capillaries. It could be shown that previous treatment of animals with procyanidolic oligomers prevented the permeability increase produced by collagenase injection.
Chester W. New (1961)

Find information about UTP Journals. University of Toronto Press is Canada’s leading academic publisher and one of the largest university presses in North America, with particular strengths in the social sciences, humanities, and business. The Book Publishing Division is widely recognized in Canada for its strength in history, political science, sociology, Indigenous studies, and cultural studies. Internationally, UTP is a leading publisher of medieval, Renaissance, Italian, Iberian, Slavic, and urban studies, as well as studies in book and print culture.
Moving object detection for real-time augmented reality applications in a GPGPU (2012)

The last generation of consumer electronic devices is endowed with Augmented Reality (AR) tools. These tools require moving object detection strategies, which should be fast and efficient, to carry out higher level object analysis tasks. We propose a lightweight spatio-temporal-based non-parametric background-foreground modeling strategy in a General Purpose Graphics Processing Unit (GPGPU), which provides real-time high-quality results in a great variety of scenarios and is suitable for AR applications.
A 12.3-mW 12.5-Gb/s Complete Transceiver in 65-nm CMOS Process (2010)

A 12.3-mW 12.5-Gb/s complete transceiver based on the 65-nm standard digital CMOS process was developed. The chip includes a clock-and-data-recovery (CDR) device, a multiplexer/demultiplexer (MUX/DEMUX), and a global clock-distribution network. To reduce power consumption, a low-swing voltage-mode driver with pulse-current boosting and an LC resonant-clock distribution with distributed on-chip inductors are used in the transmitter, while a symbol-rate phase detector (SPD) using a three-stage sense amplifier and phase-rotating phase-locked loop (PLL) with variable delay are used in the receiver. The transceiver operates at a bit error rate (BER) of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> or less through a 20-cm test board with total attenuation of -12.1 dB while consuming power of 0.98 mW/(Gb/s) per transceiver.
Yield analysis of large integrated-circuit chips (1972)

It has been experimentally observed that integrated-circuit yields decrease as their size increases and various attempts have been made to explain the variation. The authors analyze yield in terms of the geometrical factors involved in producing large chips from circular slices. It is shown that the qualitatively correct dependence of yield on area is obtained when a defect density that is higher near the outside of the slice is assumed. Results of computer program calculations of the maximum possible number of chips that can be obtained from a slice are given, assuming both random and nonrandom defect distributions.
A 2.8–3.2-GHz Fractional-$N$ Digital PLL With ADC-Assisted TDC and Inductively Coupled Fine-Tuning DCO (2013)

A 2.8–3.2-GHz fractional- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$N$</tex> </formula> digital PLL, implemented in 0.18- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$\mu \hbox{m}$</tex></formula> CMOS, is presented. The PLL architecture has the form of a classic delta-sigma fractional- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$N$</tex></formula> PLL. A PFD generates up and down pulses from the reference and divided-down digitally controlled oscillator (DCO) clock. The time-to-digital converter (TDC) converts the width of up pulses to digital words. The quantization noise introduced by a third-order delta-sigma modulator through the multi-modulus divider is canceled at the TDC output. A resistively interpolated ADC is employed to boost TDC resolution by a factor of five. A dither-less DCO with an inductively coupled fine-tuned varactor bank improves tuning step-size by a factor of 16.6, to 20 kHz. With a 52-MHz reference clock, a 3.2-GHz output clock, and a loop-bandwidth of 950 kHz, this prototype achieves 230-fs rms jitter, integrated from a 1-kHz to 40-MHz offset, while drawing 17 mW from a 1.8-V supply. The in-band phase noise floor is <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$-\hbox{111.6 dBc/Hz}$</tex></formula> at a 500-kHz offset. The reference spur is <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$-\hbox{75 dBc}$</tex></formula> and the worst-case fractional- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$N$</tex> </formula> spur, by sweeping the multiplication ratio near 61, is <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$-\hbox{55 dBc}$</tex></formula> . An FOM of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$-\hbox{240.4 dB}$</tex></formula> is achieved, and this design occupies a core area of 0.62 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\hbox{mm}^{2}$</tex> </formula> .
Replantation of digits: Factors influencing survival and functional results (1994)

Immediate survival and functional results were studied in 60 finger replants performed from 1980 to 1990. The follow-up ranged from 1 to 5 years with the mean of 2 years and 8 months. The survival rate achieved was 70% and was not related to the patient's age, the mechanism of injury, the level of amputation, the total ischemia time, the number of arteries and veins repaired or the type of vascular reconstruction. Sensory return was related to the mechanism of amputation and the total active motion was strongly correlated with the level of amputation. Of the 16 digits that had only one artery anastomosed, there were 10 survivals (62.5%), and in 15 digits with anastomosis of two arteries, the success rate was 86.66% (P = 0.1244). The success rate in those cases in which vascular grafts were employed was 62.96% (P = 0.4161). In replantations with one, two or three veins anastomosed, the survival rate was 50%, 79.16% and 100%, respectively (P = 0.1324).
On the Main Flow Pattern in Hydrocyclones (1993)

A theoretical model is developed for the prediction of the main flow pattern in hydrocyclones. The model regards the main body of the cyclone as inviscid and includes provisions for the fluid underflow in cyclones. The governing equations are solved analytically in closed form. To verify the results, a laboratory-scale conically-shaped hydrocyclone was designed, built, and tested. Experimental measurements for axial and tangential velocities are presented with a series of tests solely devoted to the effect of underflow. The theoretical and experimental results are shown to be in good agreement. It is concluded that such an inviscid model gives an adequate representation of the main flow field in a cyclone.
Circulating and Dietary <i>Trans</i> Fatty Acids and Incident Type 2 Diabetes in Older Adults: The Cardiovascular Health Study (2015)

Among older adults, plasma phospholipid t-16:1n9 and t-18:1 levels were positively related to DM after adjustment for de novo lipogenesis fatty acids. Estimated dietary TFA was not significantly associated with DM. These findings highlight the need for further observational, interventional, and experimental studies of the effects TFA on DM.
Über Alken‐(1)‐ine‐(4), II. Grignard‐Reaktionen mit Penten‐(1)‐in‐(4) und 2‐Methyl‐penten‐(1)‐in‐(4) (1964)

Abstract Die Grignard‐Verbindungen von Penten‐(1)‐in‐(4) und 2‐Methyl‐penten‐(1)‐in‐(4) wurden mit Carbonylverbindungen umgesetzt und einige der gebildeten substituierten Hexen‐(1)‐in‐(4)‐ole‐(6) weiteren Umwandlungen unterworfen.
Rhabdomyosarcoma in adults (2003)

The current series parallels other published series in that it confirms the finding of a relatively poor long-term outcome for adult patients with RMS. However, for patients whose treatment adhered to the current guidelines for treatment of children, outcome was similar to what has been reported in pediatric series. In addition, the rate of response to chemotherapy for the entire series was similar to the rate typically observed among children. These findings suggest that adults and children with RMS should receive similar treatment. Treatment protocols adopted from pediatric programs but tailored to adults could increase adults' chances of receiving appropriate treatment; prospective studies are needed to test this idea.
Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D. (1995)

We conducted a study to determine whether increasing vitamin D intake above the recommended dietary allowance (RDA) of 5.0 micrograms (200 IU)/d reduces bone loss in healthy postmenopausal women residing at latitude 42 degrees N. In this double-blind, randomized 2-y trial, we enrolled 247 healthy ambulatory postmenopausal women who consumed an average of 2.5 micrograms (100 IU) vitamin D/d in their usual diets. The women were given either 2.5 micrograms (100 IU) or 17.5 micrograms (700 IU) vitamin D/d. All women received 500 mg supplemental calcium per day as citrate malate. Duplicate hip and spine and single whole-body scans were performed by dual-energy x-ray absorptiometry at 6-mo intervals selected to flank the periods when 25-hydroxycholecalciferol (calcidiol) concentrations are highest (summer/fall) and lowest (winter/spring). Plasma calcidiol and serum osteocalcin were measured in these seasons in year 1. Both treatment groups lost bone mineral density from the femoral neck, but the 17.5-micrograms group lost less than (-1.06 +/- 0.34%; mean +/- SE) the 2.5-micrograms group (-2.54 +/- 0.37%, P = 0.003). Seventy percent of the benefit each year occurred in winter/spring and 30% in summer/fall. Changes in spinal and whole-body bone densities did not differ by treatment group and were minimal after 2 y. Serum osteocalcin and plasma calcidiol (2.5-micrograms group only) fluctuated with season. In conclusion, in healthy, calcium-supplemented, postmenopausal women residing at latitude 42 degrees N, an intake of 5.0 micrograms (200 IU) vitamin D/d is sufficient to limit bone loss from the spine and whole body but it is not adequate to minimize bone loss from the femoral neck.(ABSTRACT TRUNCATED AT 250 WORDS)
Asymmetric resolution of a parvovirus palindrome in vitro (1993)

Cell extracts from murine A9 or human HeLa cells containing wild-type copies the NS1 polypeptide of minute virus of mice (MVM), produced from a recombinant vaccinia virus, can support the resolution of viral 3' termini from palindromic junction fragments of dimeric, replicative-form MVM DNA. Resolution resulted in the generation of two new viral termini, one associated with each arm of the junction palindrome. Telomeres were created in two configurations, "extended" forms, which were covalently associated with NS1 molecules, and smaller "turn-around" forms in which a single arm of the palindrome terminated at the axis of dyad symmetry in a covalent bond which cross-linked the two strands. The in vitro resolution reaction was asymmetric, generating predominantly extended-form termini from one arm of the palindrome but predominantly turn-around forms from the other. This asymmetry was independent of the type of cell used to prepare the in vitro extract or the orientation of the palindrome in the plasmid and was obtained for all cloned junction sequences of 156 bp or more. Two modified forms of the duplex junction fragment, which appeared to be intermediates in the resolution process since they were nicked, covalently linked to NS1, and associated with newly synthesized DNA, were identified. The structures of these intermediates suggest that resolution is initiated by preferential nicking at one of the two candidate resolution sites. The asymmetric nature of this resolution reaction is discussed in terms of current models of MVM DNA replication.
Flupirtine : Clinical pharmacology (2012)

Flupirtine is neither an opioid nor a non steroidal anti-inflammatory drug (NSAID) producing its analgesic action through blockade of glutamate N-methyl-D-aspartate receptor. It is devoid of adverse effects of routinely used analgesic drugs, but is equally efficacious in reducing pain sensation. It has a distinctive mechanism of action, exerting a dual therapeutic effect with both analgesic and muscle relaxant properties that has utility in the treatment of pain, including that associated with muscle tension.
Characterization of the cell wall and cell wall proteins of Chromatium vinosum (1980)

Highly purified cell walls of Chromatium vinosum were isolated by differential centrifugation, with or without Triton X-100 extraction. The isolated material had a protein composition similar to that of cell walls obtained by sucrose density gradient centrifugation. Twenty-two proteins were reproducibly detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A 42-kilodalton protein was shown to account for 65% of the total cell wall protein. The majority of cell wall proteins were solubilized in sodium dodecyl sulfate at room temperature; however, they existed as high-molecular-weight complexes unless heated to 45 degrees C or above. The cell wall contained one heat-modifiable protein which migrated with an apparent molecular weight of 37,400 when solubilized at 70 degrees C or below, but which migrated with an apparent molecular weight of 52,500 if solubilized at 100 degrees C. The electrophoretic mobility of three proteins was modified by 2-mercaptoethanol. The majority of C. vinosum cell wall proteins had isoelectric points between pH 4.5 and 5.5, and the 42-kilodalton protein focused at pH 4.9. No proteins were detected which were analogous to the lipoprotein or peptidoglycan-associated proteins of the Enterobacteriaceae. Nearest-neighbor analysis with a reducible, cross-linking reagent indicated that three proteins, including the 42-kilodalton protein, associated with themselves. Most of the cell wall proteins were partially accessible to proteases in both intact cells and isolated cell walls. Protease treatment of the whole cell or isolated cell wall digested approximately an 11,000-molecular-weight portion of the 42-kilodalton protein.
ChemInform Abstract: SYNTHESIS OF DEOXYOLIGONUCLEOTIDES ON A POLYMER SUPPORT (1981)

Abstract Eine neue Methode für die Synthese von Desoxyoligonucleotiden wird beschrieben.
Diagnosis Performance of Different MR Imaging Signs of Cirrhosis: the Caudate to Right Lobe Ratio, the Posterior Right Hepatic Notch, and the Expanded Gallbladder Fossa. (2009)

Background & Aims The purpose of the study is to evaluate the accuracy of the C/RL, RPN, and EGF in diagnosing cirrhosis. Methods The study population included 95 cirrhotic patients in the cirrhosis group (56 men, 39 women, age range 14-76;mean age 52.3) and 57 subjects in the control group (26 men, 31 women, age range 18-83;mean age 51). All MR examinations were performed by using the same protocol. Two radiologists independently assessed data sets in two different reading sessions. The sensitivity, specificity, and accuracy and the relative risk of the signs in diagnosing cirrhosis were calculated. The diagnosis accuracy of the C/RL sign was calculated using the ROC curve. The statistical significance of any difference of each sign between different classes of cirrhosis was also calculated. Results The interobserver agreement between the readers was excellent (κ≥ 0.81;95% CI:0.92, 1.0). There was a significant statistical difference of the diagnostic value of C/RL, RPN, and EGF between cirrhotic patients and control group (p<0.001). The sensitivity, specificity, and accuracy of C/RL were 72%, 87%, and 78%; 67%, 87%, and 75% for RPN; and 49%, 91%, and 65% for EGF. C/RL (OR=18.95) and RPN (OR=14.74) showed a higher risk for cirrhosis compared to EGF (OR=14.74). There was a statistical significance difference between C/RL and EGF (p=0.002) and between RPN and EGF for Child A class of cirrhosis (p-0.037). Conclusion The C/RL and RPN have similar performance regarding the diagnosis of cirrhosis having a higher diagnostic performance compared to EGF in cirrhosis.
Brain cancer immunoediting: novel examples provided by immunotherapy of malignant gliomas (2011)

A number of studies in murine models have suggested that the immune system may edit different tumors by forcing their expression profiles so that they escape immune reactions and proliferate. Glioblastoma (GB), the most frequent and aggressive primary brain tumor, provides a good example of this, thanks to the production of numerous immunosuppressive molecules (with TGF-β being of paramount importance), downregulation of the MHC complex and deregulation of the potential for antigen presentation by the surrounding microglia. Given that surgery, radiotherapy and chemotherapy with available protocols have limited effects on the survival of GB patients, different immunotherapy strategies have been developed, based on the use of dendritic cells, antibodies and peptide vaccination. Presently, bevacizumab, a humanized anti-VEGF antibody, provides the most successful example for immune-based treatment of GB, however, its action is limited in time, as the often tumor relapses due to still undefined immunoediting mechanisms. Altered function of EGF receptor-driven pathways is common in GB and is most frequently due to the presence of a deleted form named EGFRvIII, providing a unique cancer epitope that has been targeted by immunotherapy. A recent trial of GB immunotherapy based on vaccination with the EGFRvIII peptide has shown clinical benefit: interestingly most GBs at relapse were negative for EGFRvIII expression, a relevant, direct example of cancer immunoediting. Investigations on the mechanisms of GB immunoediting will lead to an increased understanding of the biology of this malignancy and hopefully provide novel therapeutic targets.