gebhart/patrepeval huggingface dataset:
EFFECTS OF HYDROXOCOBALAMIN AND HAEMOGLOBIN ON NO‐MEDIATED RELAXATIONS IN THE RAT ANOCOCCYGEUS MUSCLE (1993)

1. The effects of hydroxocobalamin (Vitamin B12a) on relaxations produced by nitric oxide (NO), some NO-donating compounds and nitrergic nerve stimulation in isolated preparations of the rat anococcygeus muscle were compared with the effects of haemoglobin. 2. Hydroxocobalamin (30 mumol/L) significantly reduced relaxations induced by NO (0.1-3 mumol/L) and sodium nitroprusside (SNP; 0.01-0.3 mumol/L) but did not affect relaxations induced by glyceryl trinitrate (GTN; 0.01-1 mumol/L), S-nitrosocysteine (0.1-0.3 mumol/L) or stimulation of nitrergic nerves. A higher concentration of hydroxocobalamin (100 mumol/L) slightly reduced nitrergic nerve stimulation-induced relaxations. 3. Haemoglobin (10 mumol/L) blocked relaxation induced by NO and reduced relaxations induced by SNP, GTN, S-nitrosocysteine and nitrergic nerve stimulation. 4. When nitrergic nerve stimulation-induced relaxations had been partially reduced by the NO synthase inhibitor L-NAME (5-10 mumol/L), hydroxocobalamin had only a weak and transient inhibitory effect. 5. Noradrenergic contractions induced by field stimulation were not affected by hydroxocobalamin (30 mumol/L), but were enhanced by haemoglobin (10 mumol/L). 6. The results suggest that the transmitter released from nitrergic nerves in anococcygeus muscles resembles NO-releasing compounds such as S-nitrosocysteine and GTN but not SNP or free NO.
Quantification of Nitrogen Forms in Argonne Premium Coals (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantification of Nitrogen Forms in Argonne Premium CoalsS. R. Kelemen, M. L. Gorbaty, and P. J. KwiatekCite this: Energy Fuels 1994, 8, 4, 896–906Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ef00046a013https://doi.org/10.1021/ef00046a013research-articleACS PublicationsRequest reuse permissionsArticle Views964Altmetric-Citations269LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Current Research and Open Problems in Attribute-Based Access Control (2017)

Attribute-based access control (ABAC) is a promising alternative to traditional models of access control (i.e., discretionary access control (DAC), mandatory access control (MAC), and role-based access control (RBAC)) that is drawing attention in both recent academic literature and industry application. However, formalization of a foundational model of ABAC and large scale adoption is still in its infancy. The relatively recent emergence of ABAC still leaves a number of problems unexplored. Issues like delegation, administration, auditability, scalability, hierarchical representations, and the like, have been largely ignored or left to future work. This article provides a basic introduction to ABAC and a comprehensive review of recent research efforts toward developing formal models of ABAC. A taxonomy of ABAC research is presented and used to categorize and evaluate surveyed articles. Open problems are identified based on the shortcomings of the reviewed works and potential solutions discussed.
Correlation of film thickness and deposition temperature with PAI and the scalability of Ti-salicide technology to sub-0.18 μm regime (2002)

We present the first working solutions for a sub-0.25 /spl mu/m Ti-salicide process incorporating /sup 14/Si or Ar/sup +/ PAI (preamorphization implant). Various film stack thicknesses, collimated deposition temperatures, and key PAI process parameters are studied and evaluated. The use of high-temperature PVD with PAI is emphasized to yield devices with low gate sheet resistance and tight leakage distributions.
gp140, the C3d receptor of human B lymphocytes, is also the Epstein-Barr virus receptor. (1985)

The relationship between gp140, the membrane C3d receptor (CR2) of human B lymphocytes, and the Epstein-Barr virus receptor (EBVR) was analyzed by using the polyclonal anti-gp140, previously prepared by immunizing rabbits with highly purified gp140 (isolated by some of us) from CR2/EBVR-positive Raji cells. Polyclonal anti-gp72, a C3-binding membrane component, not related to the EBVR but also expressed on the Raji cell surface, was used as a control. Binding of rabbit IgG and EBV on cells was assessed by using immunofluorescence techniques with analysis by flow cytofluorometry. A semiquantitative bioassay was also used to measure the EBV binding. Polyclonal monospecific anti-gp140 IgG inhibits directly the binding of EBV to Raji cells at the same concentration that inhibits the binding of EC3d on cells, whereas a 35 times higher concentration of anti-gp72 IgG or preimmune serum IgG does not. Anti-gp140 IgG treatment also inhibits the induction of EBV-determined nuclear antigen in normal tonsil B lymphocytes or in EBV-negative Ramos cells, whereas high concentrations of anti-gp72 IgG or preimmune serum IgG have no effect. These data strongly suggest that gp140, the CR2 of human B lymphocytes, is also the EBVR.
Allosteric Modulation of M1 Muscarinic Acetylcholine Receptor Internalization and Subcellular Trafficking (2014)

Allosteric modulators are an attractive approach to achieve receptor subtype-selective targeting of G protein-coupled receptors. Benzyl quinolone carboxylic acid (BQCA) is an unprecedented example of a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR). However, despite favorable pharmacological characteristics of BQCA in vitro and in vivo, there is limited evidence of the impact of allosteric modulation on receptor regulatory mechanisms such as β-arrestin recruitment or receptor internalization and endocytic trafficking. In the present study we investigated the impact of BQCA on M1 mAChR regulation. We show that BQCA potentiates agonist-induced β-arrestin recruitment to M1 mAChRs. Using a bioluminescence resonance energy transfer approach to monitor intracellular trafficking of M1 mAChRs, we show that once internalized, M1 mAChRs traffic to early endosomes, recycling endosomes and late endosomes. We also show that BQCA potentiates agonist-induced subcellular trafficking. M1 mAChR internalization is both β-arrestin and G protein-dependent, with the third intracellular loop playing an important role in the dynamics of β-arrestin recruitment. As the global effect of receptor activation ultimately depends on the levels of receptor expression at the cell surface, these results illustrate the need to extend the characterization of novel allosteric modulators of G protein-coupled receptors to encapsulate the consequences of chronic exposure to this family of ligands.
Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2. (1991)

We previously identified a cluster of hematopoietic serine protease genes on chromosome 14 at band q11.2. This cluster contains the cathepsin G gene and the two related cathepsin G-like genes CGL-1 and CGL-2. The CGL-1 gene is identical with the cytotoxic T cell serine protease CSP-B (also called SECT, and in mice, CCP1, granzyme B, or CTLA-1). In this report, we determined that CGL-2 is identical with a recently described gene called h-CCPX. The coding sequences of CG, CGL-1, and CGL-2 are 65-75% identical at the DNA level. The intervening sequences are much less conserved, except for introns 3 of the CGL-1 and CGL-2 genes, which are 93% identical. Each of the genes has the same overall organization, with 5 exons and 4 introns, very short 5' untranslated regions, and identical splice phases for all of the introns. Cathepsin G is expressed at high levels in promyelocytes/promonocytes, and CGL-1/CSP-B is expressed at high levels in activated cytolytic T cells, lymphokine-activated killer (LAK), and natural killer (NK) cells. CGL-2/h-CCPX is expressed at much lower levels in activated peripheral blood lymphocytes, LAK and NK cells. To begin to define the regulatory elements that target expression of each of these genes to their specific lineages at specific times, the 5' flanking region of each gene was sequenced. The 5' flanking regions are minimally related and have few conserved consensus elements. Further experiments will be required to determine the critical cis-acting regulatory sequences required for tissue- and development-specific expression of each of these genes.
A SAW bandpass filter technique using a fanned multistrip coupler (1977)

A SAW filter is described which uses multistrip couplers with diferent periodicities in two adjacent tracks in order to transfer a surface wave from one track to the other over a restricted frequency band, i.e., to filter the signal. The principal advantage is good filtering with low insertion loss. Over 30-dB out-of-band rejection with 3-dB loss in the fanned multistrip coupler at a frequency of 216 MHz is demonstrated.
FRET-Based Localization of Fluorescent Protein Insertions Within the Ryanodine Receptor Type 1 (2012)

Fluorescent protein (FP) insertions have often been used to localize primary structure elements in mid-resolution 3D cryo electron microscopic (EM) maps of large protein complexes. However, little is known as to the precise spatial relationship between the location of the fused FP and its insertion site within a larger protein. To gain insights into these structural considerations, Förster resonance energy transfer (FRET) measurements were used to localize green fluorescent protein (GFP) insertions within the ryanodine receptor type 1 (RyR1), a large intracellular Ca(2+) release channel that plays a key role in skeletal muscle excitation contraction coupling. A series of full-length His-tagged GFP-RyR1 fusion constructs were created, expressed in human embryonic kidney (HEK)-293T cells and then complexed with Cy3NTA, a His-tag specific FRET acceptor. FRET efficiency values measured from each GFP donor to Cy3NTA bound to each His tag acceptor site were converted into intermolecular distances and the positions of each inserted GFP were then triangulated relative to a previously published X-ray crystal structure of a 559 amino acid RyR1 fragment. We observed that the chromophoric centers of fluorescent proteins inserted into RyR1 can be located as far as 45 Å from their insertion sites and that the fused proteins can also be located in internal cavities within RyR1. These findings should prove useful in interpreting structural results obtained in cryo EM maps using fusions of small fluorescent proteins. More accurate point-to-point distance information may be obtained using complementary orthogonal labeling systems that rely on fluorescent probes that bind directly to amino acid side chains.
Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson’s disease (2021)

Intestinal inflammatory responses and reductions in fecal SCFAs occur in PD, are related to the microbiota and to disease onset, and are not reflected in plasma inflammatory profiles. Some of these relationships are distinct in PD and are sex-dependent. This study revealed potential alterations in microbiota-host interactions and links between earlier PD onset and intestinal inflammatory responses and reduced SCFA levels, highlighting candidate molecules and pathways which may contribute to PD pathogenesis and clinical presentation and which warrant further investigation.
Resonant PZT MEMS Scanner for High-Resolution Displays (2012)

A resonant piezoelectric scanner is developed for high-resolution laser-scanning displays. A novel actuation scheme combines the principle of mechanical amplification with lead zirconate titanate (PZT) thin-film actuation. Sinusoidal actuation with 24 V at the mechanical resonance frequency of 40 kHz provides an optical scan angle of 38.5° for the 1.4-mm-wide mirror. This scanner is a significant step toward achieving full-high-definition resolution (1920 × 1080 pixels) in mobile laser projectors without the use of vacuum packaging. The reported piezoscanner requires no bulky components and consumes <; 30-mW power at maximum deflection, thus providing significant power and size advantages, compared with reported electromagnetic and electrostatic scanners. Interferometry measurements show that the dynamic deformation is at acceptable levels for a large fraction of the mirror and can be improved further for diffraction-limited performance at full resolution. A design variation with a segmented electrode pair illustrated that reliable angle sensing can be achieved with PZT for closed-loop control of the scanner.
Flux-tunable superconducting transmons for quantum information processing (2015)

In this thesis, I describe a series of experiments using flux-tunable transmon qubits for quantum information processing. These qubits are designed with different levels of Josephson junction asymmetry. The first two chapters of this thesis will introduce the reader to superconducting qubits and circuit quantum electrodynamics. I will present experiments using the cQED architecture to implement fast photon swapping between an asymmetric qubit and a superconducting resonator using flux-driven sidebands. This is the first experimental observation of flux-driven sidebands in a superconducting system. This process also allows photon swaps between qubit and resonator to first order in the qubit-resonator coupling strength. I will detail an experiment to study and optimize an all-microwave two-qubit gate using the cross-resonance effect. This work constitutes the first experimental study of the cross-resonance effect vs. frequency and confirms effects from the higher energy levels of the transmon in the effective coupling during a cross-resonant drive. Lastly, I will outline a theoretical analysis and initial experiments to study the coherence properties of asymmetric transmons.
Irish Gold Crescents (1921)

Since their first publication in 1757 ( Archaeologia , ii, 32, pl. ii), the gold crescents characteristic of the Early Bronze Age of Ireland have remained in part unexplained; and the various names suggested for them reflect the prevailing uncertainty as to their use and significance. In his recently published Catalogue of Irish Gold Ornaments , our Fellow Mr. Armstrong has brought together all the existing material, and on consideration adopts the view that these gold crescents were worn as collars. They at first went under the name of lunulae or little moons, and a favourite term in later years has been lunette , which is generally used in French for ‘telescope’, and though more manageable than lunula , is not so fitted for international use as ‘crescent’.
The SIP-Based System Used in Connection with a Firewall (2006)

Different methods, such as ALG, STUN, TURN and FCP have been proposed for using SIP together with firewalls and NAT. The most suitable solution has to be determined in every situation. Some of these methods cause more network traffic and capacity requirements, while others require support from the clients being used in the network. In this paper a system which makes it possible to offer SIP service to customers behind NAT without making any changes to firewalls is presented. The system is based on an RTP proxy and a SIP server, which modifies SIP messages.
Deeply etched MMI-based components on 4 μm thick SOI for SOA-based optical RAM cell circuits (2013)

We present novel deeply etched functional components, fabricated by multi-step patterning in the frame of our 4 μm thick Silicon on Insulator (SOI) platform based on singlemode rib-waveguides and on the previously developed rib-tostrip converter. These novel components include Multi-Mode Interference (MMI) splitters with any desired splitting ratio, wavelength sensitive 50/50 splitters with pre-filtering capability, multi-stage Mach-Zehnder Interferometer (MZI) filters for suppression of Amplified Spontaneous Emission (ASE), and MMI resonator filters. These novel building blocks enable functionalities otherwise not achievable on our SOI platform, and make it possible to integrate optical RAM cell layouts, by resorting to our technology for hybrid integration of Semiconductor Optical Amplifiers (SOAs). Typical SOA-based RAM cell layouts require generic splitting ratios, which are not readily achievable by a single MMI splitter. We present here a novel solution to this problem, which is very compact and versatile and suits perfectly our technology. Another useful functional element when using SOAs is the pass-band filter to suppress ASE. We pursued two complimentary approaches: a suitable interleaved cascaded MZI filter, based on a novel suitably designed MMI coupler with pre-filtering capabilities, and a completely novel MMI resonator concept, to achieve larger free spectral ranges and narrower pass-band response. Simulation and design principles are presented and compared to preliminary experimental functional results, together with scaling rules and predictions of achievable RAM cell densities. When combined with our newly developed ultra-small light-turning concept, these new components are expected to pave the way for high integration density of RAM cells.
Bone regeneration in alveolar bone dehiscences produced by jiggling forces (1982)

The aim of this experiment was to achieve support for the hypothesis that bone resorption, induced by jiggling forces, leaves a component within the supracrestal soft tissue with a capacity of reforming bone. The maxillary lateral incisors and first premolars and the mandibular second premolars in two monkeys were used in the study. Using metal pins inserted into the neighboring teeth as retainers, orthodontic elastics were stretched and placed alternately around the buccal and lingual surfaces of each experimental tooth in order to produce jiggling forces. After 5 months of continuous jiggling, when bone dehiscences were produced on the buccal aspect of the teeth, the elastics were removed. After repositioning of the teeth a split thickness flap was raised. On one side of the jaw the soft tissue within the bone dehiscences was removed. At the contralateral teeth a sham operation was performed maintaining the soft tissue within the bone dehiscences. The monkeys were sacrificed 6 months after surgery. Tissue blocks containing test and control specimens were dissected free and prepared for microscopic analysis. The length of the supracrestal connective tissue attachment and the amount of coronal bone regeneration were assessed in the histological sections. It was found that buccal alveolar bone, reduced in height by jiggling forces, regenerated after discontinuation of the forces. When the soft tissue within the buccal bone dehiscences produced by the jiggling forces was surgically removed, the coronal regeneration of the alveolar bone was markedly reduced. These observations suggest that bone resorption, induced by jiggling forces, leaves a soft tissue component with a capacity of forming bone.
Podoplanin as a marker for mesothelioma (2005)

Podoplanin is a specific marker for lymph vessel endothelial cells. It was noted that podoplanin is expressed in reactive mesothelial cells. The utility of podoplanin for the histological diagnosis of tumors was then investigated, especially for mesothelioma. Immunohistochemical study of podoplanin was carried out in five malignant mesotheliomas and 118 other tumors including 93 adenocarcinomas, four squamous cell carcinomas, six gastrointestinal stromal tumors and five endocrine tumors. Immunoreactivity for podoplanin was demonstrated on the cell membrane of tumor cells for all mesotheliomas. All other tumors were negative for podoplanin. Among the many antibodies used for differential diagnosis of malignant mesothelioma, podoplanin has the potential to be an excellent tumor marker in both specificity and sensitivity. The utility of podoplanin as a marker for mesothelioma will be confirmed by further studies.
One-step realization of open-ended TiO2 nanotube arrays by transition of the anodizing voltage (2010)

Free-standing TiO2 nanotubes with both their ends open are required in many applications. This article reports the authors’ latest progress in meeting these requirements. Elevating the voltage at the end of an anodization process can break the adhesion of the TiO2 nanotube layer to the underlying Ti substrate and simultaneously open their bottoms. Furthermore, by modulating the value and duration of the elevated voltage, the bottom morphology of the nanotubes can also be effectively tailored. Compared with most of the related work, in which obtaining free-standing TiO2 nanotube layers and opening their bottom ends are often performed in two separate procedures, this newly-developed route features a simple one-step solution and also good controllability. Both the detachment of the nanotubes from the Ti substrate and the tailoring of their bottom ends are ascribable to the local acidification and gas evolution induced by the sudden voltage transition.
Fluorescent whitening agents in detergents. (1975)

Washing is a form of textile care which is characterized by its repetitive nature. Washing methods vary enormously in different parts of the world. The main types of detergents and fluorescent whitening agents (FWAs) are described. Washing slows down the deterioration in use of white goods, and yellowing is counteracted by FWAs. FWAs also enhance the freshness and brightness of most pale shades. Cost calculations show clearly the economic advantages of using FWAs in washing: the useful life of textiles can be prolonged considerably for a very small additional cost.