gebhart/patrepeval huggingface dataset:
Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae. (1992)

We have isolated mutants that inhibit membrane protein insertion into the ER membrane of Saccharomyces cerevisiae. The mutants were contained in three complementation groups, which we have named SEC70, SEC71, and SEC72. The mutants also inhibited the translocation of soluble proteins into the lumen of the ER, indicating that they pleiotropically affect protein transport across and insertion into the ER membrane. Surprisingly, the mutants inhibited the translocation and insertion of different proteins to drastically different degrees. We have also shown that mutations in SEC61 and SEC63, which were previously isolated as mutants inhibiting the translocation of soluble proteins, also affect the insertion of membrane proteins into the ER. Taken together our data indicate that the process of protein translocation across the ER membrane involves a much larger number of gene products than previously appreciated. Moreover, different translocation substrates appear to have different requirements for components of the cellular targeting and translocation apparatus.
Chain Transfer in the Ring-Opening Metathesis Polymerization of Cyclooctadiene Using Discrete Metal Alkylidenes (1995)

The ring-opening metathesis polymerization of cyclooctadiene (COD) in the presence of a\ndifunctional chain transfer agent (CTA) was investigated. The effect of the CTA structure and choice of\nmetathesis catalyst on the overall efficiency of the polymerization reaction is discussed. A separation of\nthe oxygen functionality from the olefin in the CTA by two methylene units significantly enhances the\nstability of the discrete, tungsten-based metathesis catalyst used for these polymerizations. Furthermore,\na more robust well-defined metathesis catalyst based on molybdenum was more effective than the\ntungsten-based catalyst. The preparation oflow-molecular-weight hydroxytelechelic polybutadienes with\none type of regiochemistry, number-average functionalities that approach 2.0, and in high yield was\naccomplished.
Bone Morphogenesis of Rabbit Bone Morphogenetic Protein-Bound Hydroxyapatite-Fibrin Composite (1991)

Hydroxyapatite (HAP) and fibrin have been implanted in patients and observed to be well tolerated in orthotopic sites. This is a report on a composite of HAP, fibrin, and rabbit bone morphogenetic protein and insoluble noncollagenous protein (BMP-iNCP). Drill holes in the femoral condyles of rabbits were packed with granulated HAP (200 mg), fibrin (0.3 ml), BMP-iNCP (5 mg), or various combinations of the two. The fibrin consisted mainly of sterilized human fibrinogen and thrombin, and BMP-iNCP was prepared from demineralized rabbit cortical bone. New bone formation was observed at one, two, four, and eight weeks after implantation. The BMP-iNCP augmented new bone formation in rabbit femoral condyles. Fibrin made the composite easier to manipulate and did not inhibit osteogenesis at any period. The composites of HAP with BMP-iNCP and of HAP with BMP-iNCP and fibrin produced higher yields of new bone than fibrin alone or HAP alone.
Basic Holographic Characteristics of Panchromatic Light Sensitive Material for Reflective Auto Stereoscopic 3D Display (2007)

Basic holographic characteristics of a newly developed panchromatic ultra-fine grain silver halide light sensitive material for RGB recording of reflective holographic screen for auto stereoscopic 3D display are presented. The average grain size is less than 10 nm which ensures a large dynamic range and high resolution, diffraction efficiency and signal to noise ratio (more than 100:1) in RGB reflective holographic recording. The decrease of the diffraction efficiency in reflection holographic recording of scattering objects is less than 30% from the maximal values for specular reflection. The analysis of the color characteristics of the reflective holographic screen for the needs of an auto stereoscopic 3D display with single and multiple viewing zones is presented on the basis of so called "sandwich" structure of two layers for separate holographic recording in blue, green and red spectral regions.
사상성격검사(SPQ)의 임상 타당화 연구 (2012)

Objectives : The purpose of this study was to validate the Sasang Personality Questionnaire (SPQ), based on the diagnosis of Sasang constitutional medicine clinical specialist. Methods : We performed Sasang type differentiation of 103 college students by certified specialist, and analyzed biopsychological traits of each groups with SPQ, Temperament and Character Inventory (TCI), Positive and Negative Affection Schedule (PANAS) and Body Mass Index (BMI). Results : The SPQ score of So-Yang (33.1±0.79), Tae-Eum (29.03±0.67) and So-Eum (25.76±0.98) Sasang groups showed significant differences from each other. The SPQ showed significant correlation with TCI Novelty-Seeking (r=.346), TCI Harm-Avoidance (r=-.348) and TCI Persistence (r=.346). But the BMI and PANAS did not show significant correlation with SPQ, although the PANAS Positive Affection (r=.332) has significant correlation with SPQ-Behavior. Conclusions : We confirmed the clinical validity of SPQ with clinical specialist and established biopsychosocial instruments. This study would contribute to a more objective diagnosis and studies on biopsychosocial mechanism of Sasang constitutional medicine.
The Postural Tachycardia Syndrome (2007)

Postural tachycardia syndrome (POTS) is a disorder of unknown etiology, and patients with this condition exhibit orthostatic intolerance (OI) and excessive tachycardia. Excessive tachycardia with POTS has been defined as a rapid (within 10 minutes) increase in heart rate by more than 30 beats per minute or a heart rate that exceeds 120 beats per minute. Patients with POTS can experience difficulty with daily routines such as housework, shopping, eating, and attending work or school. The possibility exists that all forms of OI, including POTS, result from central hypovolemia even without tachycardia. The clinical findings of POTS are observed in an increasing number of patients who are usually female and aged 15 to 50 years. Adults with POTS do not have hypotension, whereas children may exhibit hypotension. Many patients with POTS are intolerant of exercise. "Idiopathic" POTS must be distinguished from other conditions that can reduce venous return to the heart and produce similar signs and symptoms such as dehydration, anemia, or hyperthyroidism. Therapies for POTS are directed at relieving the central hypovolemia or at compensating for the circulatory dysfunctions that may cause this disorder. Treatments have resulted in varying degrees of success and are often used in combination with each other.
Comparison of nine common coffee extraction methods: instrumental and sensory analysis (2013)

The preparation of a cup of coffee may vary between countries, cultures and individuals. Here, an analysis of nine different extraction methods is presented regarding analytical and sensory aspects for four espressi and five lunghi. This comprised espresso and lungo from a semi-automatic coffee machine, espresso and lungo from a fully automatic coffee machine, espresso from a single-serve capsule system, mocha made with a percolator, lungo prepared with French Press extraction, filter coffee and lungo extracted with a Bayreuth coffee machine. Analytical measurements included headspace analysis with HS SPME GC/MS, acidity (pH), titratable acidity, content of fatty acids, total solids, refractive indices (expressed in °Brix), caffeine and chlorogenic acids content with HPLC. Sensory analysis included visual, aroma, flavor and textural attributes as well as aftersensation. The technical differences in the extraction methods led to a higher concentration of the respective quantities in the espressi than in the lunghi. Regarding the contents per cup of coffee, the lunghi generally had a higher content than the espressi. The extraction efficiency of the respective compounds was mainly driven by their solubility in water. A higher amount of water, as in the extraction of a lungo, generally led to higher extraction efficiency. Comparing analytical data with sensory profiles, the following positive correlations were found total solids ↔ texture/body, headspace intensity ↔ aroma intensity, concentrations of caffeine/chlorogenic acids ↔ bitterness and astringency.
The tungsten‐containing formate dehydrogenase from <i>Methylobacterium extorquens</i> AM1: Purification and properties (2002)

NAD-dependent formate dehydrogenase (FDH1) was isolated from the alpha-proteobacterium Methylobacterium extorquens AM1 under oxic conditions. The enzyme was found to be a heterodimer of two subunits (alpha1beta1) of 107 and 61 kDa, respectively. The purified enzyme contained per mol enzyme approximately 5 mol nonheme iron and acid-labile sulfur, 0.6 mol noncovalently bound FMN, and approximately 1.8 mol tungsten. The genes encoding the two subunits of FDH1 were identified on the M. extorquens AM1 chromosome next to each other in the order fdh1B, fdh1A. Sequence comparisons revealed that the alpha-subunit harbours putative binding motifs for the molybdopterin cofactor and at least one iron-sulfur cluster. Sequence identity was highest to the catalytic subunits of the tungsten- and selenocysteine-containing formate dehydrogenases characterized from Eubacterium acidaminophilum and Moorella thermoacetica (Clostridium thermoaceticum). The beta-subunit of FDH1 contains putative motifs for binding FMN and NAD, as well as an iron-sulfur cluster binding motif. The beta-subunit appears to be a fusion protein with its N-terminal domain related to NuoE-like subunits and its C-terminal domain related to NuoF-like subunits of known NADH-ubiquinone oxidoreductases.
Cutting sp2 clusters in graphene sheets into colloidal graphene quantum dots with strong green fluorescence (2012)

Water-soluble and well-crystallized graphene quantum dots with lateral size about 3.0 nm were fabricated by a hydrothermal cutting method and their photoluminescence (PL) properties as well as the potential for bioimaging were demonstrated.
Towards Specification Based Testing for Semantic Web Services (2009)

Web services have become popular in the modern infrastructure of the World Wide Web. They aim to provide automatic discovery, selection, and invocation of required applications (services) across the internet. However, the quality assurance aspects of Web services remain a challenge. Recently, the semantic Web has been introduced as an emerging technology which emphasizes presenting the meaning of the Web content to achieve a machine processable automation. In this paper, we explore the synergy of applying specification based software testing techniques to semantic Web services. Our approach investigates the possibility of deriving concrete test cases from the goal specification of a semantic web service in order to determine the correctness of a service implementation. Furthermore, we also propose coverage criteria to evaluate the generated test cases at both the goal and the service description levels. We demonstrate the generation and evaluation of the test cases from a goal specification with the help of a simplified discount example.
Modeling and Evaluation of Software Defined Networking Based 5G Core Network Architecture (2021)

Nowadays, the increase in the number of mobile users and cellular traffic leads to new challenges in the fifth-generation (5G) of cellular networks. The increase in the demand for high data rates brings challenges like scalability and flexibility in the 5G network. Software-defined networking (SDN) is a network paradigm that separates the control plane and data plane in the network and ease the management of the network. In this work, an SDN based 5G core architecture is proposed, in order to introduce flexibility and ease of management in the network. Another benefit of using SDN is to make the network vendor-independent. Furthermore, the explanation of initial attachment and handover procedures in the proposed architecture is provided. A network simulator is built to evaluate the performance of proposed architecture, in terms of end-to-end delay, throughput and resource utilization of controller, under different network factors. A performance comparison, in terms of end-to-end delay, between proposed SDN based 5G architecture and traditional 5G architecture is provided. Results show that the proposed architecture provides 18% to 62% less end-to-end delay, under different factors for different procedures, compared to the traditional 5G architecture. A comparison with previous works is also provided, which indicates similar trends in delay between our work and previous studies.
Osmium-Catalyzed Dihydroxylation of Olefins in Acidic Media: Old Process, New Tricks (2002)

A screen of over 500 diversely functionalized additives in osmium-catalyzed dihydroxylation has uncovered that electron-deficient olefins are converted into the corresponding diols much more efficiently when the pH of the reaction medium is maintained on the acidic side. Further studies have identified citric acid as the additive of choice, for it allows preparation of very pure diols in yields generally exceeding 90%. As described here, a much wider range of olefin classes can now be successfully dihydroxylated. The process is experimentally simple, in most cases involving little more than dissolving the reactants in water or a water/tert-butyl alcohol mixture, stirring them, and filtering off the pure diol product.
Hydrothermal Synthesis of Ultra-Light Coal-Based Graphene Oxide Aerogel for Efficient Removal of Dyes from Aqueous Solutions (2018)

A novel carboxymethyl cellulose (CMC)-supported graphene oxide aerogel (CGOA) was fabricated from a cost-effective and abundant bituminous coal by a mild hydrothermal process and freeze-drying treatment. Such an aerogel has cross-linked graphene oxide layers supported by CMC, and therefore, displays high mechanical strength while having ultra-low density (8.257 mg·cm<sup>-3</sup>). The CGOA has a 3D interconnected porous structure, beneficial graphene framework defects and abundant oxygen-containing functional groups, which offer favorable diffusion channels and effective adsorption sites for the transport and adsorption of dye molecules. The adsorption performance of rhodamine B by an optimized CGOA shows a maximum monolayer adsorption capacity of 312.50 mg·g<sup>-1</sup>, as determined by Langmuir isotherm parameters. This CGOA exhibited a better adsorption efficiency (99.99%) in alkaline solution, and satisfactory stability (90.60%) after three cycles. In addition, adsorption experiments on various dyes have revealed that CGOA have better adsorption capacities for cationic dyes than anionic dyes.
Improved selectivity in spectroscopy by multivariate calibration (1987)

Abstract This paper illustrates some advantages of indirect multivariate calibration over conventional calibration: selectivity enhancement and outlier detection. Partial least squares (PLS) calibration is applied for quantitative analysis in the presence of interferences that would make both conventional single‐wavelength calibration and direct multicomponent analysis impossible. The PLS algorithm is illustrated graphically, and the importance of outlier detection is demonstrated.
Blockade or reversal of the contraction induced by calcium and adrenaline in depolarized arterial smooth muscle (1969)

1. Mesenteric arteries immersed in a depolarizing solution contract in the presence of calcium. These contractions are proportional to the calcium concentration and are reversible.2. Mesenteric arteries immersed in a calcium-free depolarizing solution contract in the presence of adrenaline. Under the experimental conditions reported here, this response develops only about one-third of the contractile tension developed in polarizing solution (modified Krebs bicarbonate).3. Cinnarizine and chlorpromazine inhibit the contractile response to calcium and induce relaxation of depolarized muscle previously contracted by calcium; cinnarizine was 4 times more potent than chlorpromazine in such activity.4. Chlorpromazine inhibits the response to adrenaline in both polarizing and calcium-free depolarizing solutions, whereas cinnarizine inhibits the response in polarizing solution but not that in calcium-free depolarizing solution.5. The significance of these results is discussed.
In vitro andin vivo chemotactic effect of mip-lα gene transfected tumor vaccine on immune effector cells (1997)

Vaccination with chemokine gene-transfected tumor cells may be a new apporach to cancer treatment. Macrohage inflammatory protein-la (MIP-lα ) is a new type of chemokines which has chemotactic activity on effector cells. In the present study, the B16 melanoma cells were transfected with recombinant adenovirus harboring murine MIP-1α gene. The biological characteristics of the MIP-lα gene transfected B16 melanoma cells were investigated. The level of MlP-lα in the supernatant of gene-transfected melanoma cells was 368±24 ng/ml/106/24hr. This supernatant showed strong chematactic activity for NK cells, CD4+ T cells, CD8+ T cells or the freshly isolated peritoneal macrophages. Though thein vitro growth were not altered, the tumorigenicity of the gene-transfected B16 melanoma cells decreased signicantly. The infiltration of inflammatory cells into the tumor mass formed by MIP-lα gene-transfected B16 cells were much more obvious than that by wild-type B16 cells or B16 cells transfected with the control gene. However, the survival time of the mice bearing B16 melanoma cells transfected with MIP-1 a gene was not prolonged and the NK, CTL activity remianed unchanged. We suggested that thein vivo phenomenon may be related to the high toxicity of the MIP-1 α as a strong non-specific inflam-matory mediator.
The Polar Flagellar Motor of <i>Vibrio cholerae</i> Is Driven by an Na <sup>+</sup> Motive Force (1999)

Vibrio cholerae is a highly motile bacterium which possesses a single polar flagellum as a locomotion organelle. Motility is thought to be an important factor for the virulence of V. cholerae. The genome sequencing project of this organism is in progress, and the genes that are highly homologous to the essential genes of the Na+-driven polar flagellar motor of Vibrio alginolyticus were found in the genome database of V. cholerae. The energy source of its flagellar motor was investigated. We examined the Na+ dependence and the sensitivity to the Na+ motor-specific inhibitor of the motility of the V. cholerae strains and present the evidence that the polar flagellar motor of V. cholerae is driven by an Na+ motive force.
<i>Helicobacter pylori</i> treatment in the era of increasing antibiotic resistance (2010)

With few exceptions, the most commonly recommended triple Helicobacter pylori regimen (proton pump inhibitor (PPI), amoxicillin and clarithromycin) now provides unacceptably low treatment success. A review of worldwide results suggests that successful eradication using a triple regimen is not consistently observed in any population. Clinicians should use 'only use what works locally' and ignore consensus statements and society guidelines if they are not consistent with local results. Clinical trials should be result based, with the goal of identifying regimens with >90-95% success. New treatments should be only be compared with the currently locally effective treatment (>90%) or a historical untreated control (which has been shown to reliably yield 0% eradication); trials using placebos or treatments known to be inferior are with rare exceptions unethical. If a highly effective regimen is not available locally, we recommend trying a 14 day concomitant quadruple treatment regimen containing a PPI, amoxicillin, clarithromycin and a nitroimidazole; 10 day sequential treatment (PPI plus amoxicillin for 5 days followed by a PPI, clarithromycin and a nitroimidazole for 5 days); or 14 day bismuth-containing quadruple treatments. Treatments needing further evaluation include those containing furazolidone or nitazoxanide, hybrids of sequential-concomitant therapies and amoxicillin-PPI dual therapy with PPI doses such that they maintain intragastric pH >6.
Strong Viscous-Inviscid Interaction and the Effects of Streamline Curvature (1997)

Asymptotic theory has led to the development of the quasi-simultaneous method for treating viscous-inviscid interaction.In the present paper we s u m m a rize this historical relation.Furthermore it is demonstrated how e ects of streamline curvature can be included in this framework.
The Design of New Journaling File Systems: The DualFS Case (2007)

This paper describes the foundation, design, implementation, and evaluation of DualFS, a new high-performance journaling file system which has the same consistency guarantees as traditional journaling file systems but a greater performance. DualFS places data and metadata in different devices (usually, two partitions of the same storage device) and manages them in very different ways. The metadata device is organized as a log-structured file system, whereas the data device is organized as groups. The new design allows DualFS not only to recover the consistency quickly after a system crash, but also to improve the overall file system performance. We have evaluated DualFS and we have found that it greatly reduces the total I/O time taken by the file system in most workloads as compared to other file systems (Ext2, Ext3, ReiserFS, XFS, and JFS). The work carried out has also allowed us to draw some lessons which ought to be taken into account when implementing new file systems
MDP and Machine Learning-Based Cost-Optimization of Dynamic Resource Allocation for Network Function Virtualization (2015)

The introduction of Network Functions Virtualization (NFV) enables service providers to offer software-defined network functions with elasticity and flexibility. Its core technique, dynamic allocation procedure of NFV components onto cloud resources requires rapid response to changes on-demand to remain cost and QoS effective. In this paper, Markov Decision Process (MDP) is applied to the NP-hard problem to dynamically allocate cloud resources for NFV components. In addition, Bayesian learning method is applied to monitor the historical resource usage in order to predict future resource reliability. Experimental results show that our proposed strategy outperforms related approaches.