gebhart/patrepeval huggingface dataset:
Closed-Loop Single-Beacon Passive Acoustic Navigation for Low-Cost Autonomous Underwater Vehicles (2018)

Accurate localization is critical for a robotic vehicle to navigate autonomously. Conventional autonomous underwater vehicles (AUV s) typically rely on an inertial navigation system (INS) aided by a Doppler velocity log (DVL) in order to reduce the rate of positional error growth of dead-reckoning to a level suitable for reliable navigation underwater. The size, cost, and power requirements of these systems result in vehicles that are prohibitively large and expensive for multi-AUV operations. In this work we present the first results of closed-loop experiments using a miniature, low-cost SandShark AUV and a custom-designed, inexpensive acoustic system first described in our previous work. Results are validated using an independent LBL system, and indicate that our approach is suitably accurate to enable the self-localization of such AUVs without the use of an expensive DVL-aided INS. Self-localization is performed by obtaining acoustic range and angle measurements from the AUV to a single acoustic beacon using a vehicle-mounted passive hydrophone receiver-array, and fusing these measurements using a particle filter. A critical aspect of our approach that allows for real-time, closed-loop operation is the close coupling of conventional phased-array beamforming and particle filtering - this implementation detail reduces the computational complexity associated with our previously described two-stage beamforming plus particle filtering process, and consequently also enables an increase in particle count and an improvement in navigational accuracy. Experimental results are provided for two cases: first, absolute navigation in the case where the beacon is fixed at a known position; and second, relative navigation with a moving beacon, a novel operating paradigm for AUVs which promises to enable multi-AUV operations while maintaining bounded navigation error.
Unsupervised Feature Learning and Deep Learning: A Review and New Perspectives (2012)

The success of machine learning algorithms generally depends on data representation, and we hypothesize that this is because different representations can entangle and hide more or less the different explanatory factors of variation behind the data. Although specific domain knowledge can be used to help design representations, learning with generic priors can also be used, and the quest for AI is motivating the design of more powerful representation-learning algorithms implementing such priors. This paper reviews recent work in the area of unsupervised feature learning and deep learning, covering advances in probabilistic models, auto-encoders, manifold learning, and deep networks. This motivates longer-term unanswered questions about the appropriate objectives for learning good representations, for computing representations (i.e., inference), and the geometrical connections between representation learning, density estimation and manifold learning.
The Arabidopsis Circadian System (2002)

Rhythms with periods of approximately 24 hr are widespread in nature. Those that persist in constant conditions are termed circadian rhythms and reflect the activity of an endogenous biological clock. Plants, including Arabidopsis, are richly rhythmic. Expression analysis, most recently on a genomic scale, indicates that the Arabidopsis circadian clock regulates a number of key metabolic pathways and stress responses. A number of sensitive and high-throughput assays have been developed to monitor the Arabidopsis clock. These assays have facilitated the identification of components of plant circadian systems through genetic and molecular biological studies. Although much remains to be learned, the framework of the Arabidopsis circadian system is coming into focus.DedicationThis review is dedicated to the memory of DeLill Nasser, a wonderful mentor and an unwavering advocate of both Arabidopsis and circadian rhythms research.
In vitro antagonism by erythromycin of the bactericidal action of antimicrobial agents against common respiratory pathogens (1980)

Ten strains each of Staphylococcus aureus, Haemophilus influenzae, Enterobacter spp., Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Streptococcus pneumoniae were tested in vitro against erythromycin combined with ampicillin, cefamandole, or gentamicin. Antagonism by erythromycin occurred with 47% of the combinations involving strains of S. aureus and to a lesser degree with H. influenzae. Synergy occurred most commonly with H. influenzae (27%). The high frequency of antagonism and synergy with these organisms was associated with a broad range of bacteriostatic action by erythromycin against these same bacteria. The implications for the treatment of pneumonia are discussed.
Intelligence Packet Scheduling for optimized video transmission over wireless networks (2007)

This paper presents an intelligent packet scheduling scheme based on an analytical distortion model for Multi-Referenced H.264 video over 802.11 wireless networks. This model considers that video distortion in H.264 video codecs is based on multi-reference video frames, as opposed to previous video
Sample size determination for the interval estimation of the mean or median of a distribution (1981)

A nonsequential procedure for determining an appropriate sample size for the interval estimation or the mean or median of a distribution is proposed. The procedure is based on the expected coverage of the confidence interval and requires no prior information concerning the degree of dispersion of the distribution. Tables of minimum sample sizes required for use in the estimation of the mean of an exponential distribution. mean of a normal distribution and median of any continuous distribution are provided. Asymptotic approximations to the minimum sample sizes required in these three cases are also given. Large sample confidence intervals for the mean are also discussed.
Adding Human Learning in Brain--Computer Interfaces (BCIs) (2015)

In this article, we introduce CLBCI (Co-Learning for Brain--Computer Interfaces), a BCI architecture based on co-learning in which users can give explicit feedback to the system rather than just receiving feedback. CLBCI is based on minimum distance classification with Independent Component Analysis (ICA) and allows for shorter training times compared to classical BCIs, as well as faster learning in users and a good performance progression. We further propose a new scheme for real-time two-dimensional visualization of classification outcomes using Wachspress coordinate interpolation. It allows us to represent classification outcomes for n classes in simple regular polygons. Our objective is to devise a BCI system that constitutes a practical interaction modality that can be deployed rapidly and used on a regular basis. We apply our system to an event-based control task in the form of a simple shooter game in which we evaluate the learning effect induced by our architecture compared to a classical approach. We also evaluate how much user feedback and our visualization method contribute to the performance of the system.
Effect of polysilicon-emitter shape on dopant diffusion in polysilicon-emitter transistors (1989)

The shape of the polysilicon region of a polysilicon-emitter transistor fabricated with a single layer of polysilicon depends on the processing conditions and can vary considerably. When the boundary between the polysilicon and the adjacent oxide is not vertical, the anisotropic dopant diffusivity in polysilicon can limit the ability of the dopant to diffuse to the corner, restricting the effectiveness of the polysilicon as a diffusion source in this region. In the extreme case, the junction may be located in the polysilicon, rather than in the underlying single-crystal silicon, causing large leakage currents and degrading the transistor gain.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Multiple Hydrogenation Insert. (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple Hydrogenation Insert.R. A. Eisenhauer and R. E. BealCite this: Anal. Chem. 1963, 35, 8, 1110Publication Date (Print):July 1, 1963Publication History Published online1 May 2002Published inissue 1 July 1963https://pubs.acs.org/doi/10.1021/ac60201a066https://doi.org/10.1021/ac60201a066research-articleACS PublicationsRequest reuse permissionsArticle Views12Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular Profile of the<i>BCL2</i>Family of the Apoptosis Related Genes in Breast Cancer Cells after Treatment with Cytotoxic/Cytostatic Drugs (2008)

BCL2 (bcl-2) gene family members are important regulators of apoptosis. Increasing evidence supports their modulated expression in breast cancer cells and in many cases their relation to chemotherapy response, outcome, and overall prognosis, as well as their value as important potent therapeutic targets. Investigation and increased understanding of their transcriptional regulation and their specific roles in cancer progression and therapy response will be useful for focusing research on the development of novel therapies targeted against this gene family members' expression status. In the present review, we describe current knowledge of the molecular profile of the classical and novel members of the BCL2 family of genes as a response of breast cancer cells to cytotoxic/cytostatic drugs.
A novel locus for X-linked recessive CMT with deafness and optic neuropathy maps to Xq21.32-q24 (2005)

The authors describe a Korean family with X-linked recessive Charcot-Marie-Tooth disease (CMT) having deafness and optic neuropathy. An X chromosome-wide linkage analysis identified a 15.2-cM candidate region flanked by DXS990 and DXS8067 on Xq21.32-q24 with the maximum lod score at DXS8077 (3.62, theta = 0.00). This locus does not overlap previously identified four loci for X-linked CMT, and the authors propose it as CMTX5.
Model-based compliant motion control scheme for assembly tasks using vision and force information (2013)

This paper proposes model-based compliant motion control scheme for assembly tasks using vision and force information. Many problems, especially assembly tasks, could be solved by integrating visual servoing and impedance control with model-based compliant motion design, in which the coordinate frame of the impedance control is attached to the model of assembled object. To implement the model-based compliant motion control scheme, real-time model-based object pose estimation is used for the visual servoing implemented by a position-based approach. The coordinate frame used for the impedance control, which is attached to the object model, is determined based on the estimated object pose. The proposed control is effective for assembly of two parts like connector insertion task, in which the compliant motion should be designed according to the geometric structure of the assembled part, such as a shape of a socket. Finally, experimental results illustrate the effectiveness of the proposed control.
Extended Low-Frequency Performance of Existing Loudspeaker Systems (1984)

On presente des equations de conception pour montrer comment augmenter la reponse a basse frequence d'un systeme de haut parleurs reflex existant en utilisant un egaliseur actif decrit par Stahl
Src Family Tyrosine Kinase Regulates Intracellular pH in Cardiomyocytes (1998)

The Anion Cl-/HCO3- Exchangers AE1, AE2, and AE3 are membrane pH regulatory ion transporters ubiquitously expressed in vertebrate tissues. Besides relieving intracellular alkaline and CO2 loads, the AEs have an important function during development and cell death and play a central role in such cellular properties as cell shape, metabolism, and contractility. The activity of AE(s) are regulated by neurohormones. However, little is known as to the intracellular signal transduction pathways that underlie this modulation. We show here that, in cardiomyocytes that express both AE1 and AE3, the purinergic agonist, ATP, triggers activation of anion exchange. The AE activation is observed in cells in which AE3 expression was blocked but not in cells microinjected with neutralizing anti-AE1 antibodies. ATP induces tyrosine phosphorylation of AE1, activation of the tyrosine kinase Fyn, and association of both Fyn and FAK with AE1. Inhibition of Src family kinases in vivo by genistein, herbimycin A, or ST638 prevents purinergic activation of AE1. Microinjection of either anti-Cst.1 antibody or recombinant CSK, both of which prevent activation of Src family kinase, significantly decreases ATP-induced activation of AE. Microinjection of an anti-FAK antibody as well as expression in cardiomyocytes of Phe397 FAK dominant negative mutant, also prevents purinergic activation of AE. Therefore, tyrosine kinases play a key role in acute regulation of intracellular pH and thus in cell function including excitation-contraction coupling of the myocardium.
Safety and Efficacy Study of N‐SORB <sup>®</sup> a Proprietary KD120 MEC Metabolically‐ Activated Enzyme Formulation: A Randomized, Double‐blind, placebo Controlled Study (2019)

Background Enzymes are crucial for all aspects of metabolic function. Digestive enzymes from natural sources have been credited with beneficial effects in the digestion and absorption of food. N‐SORB is a novel KD120 multienzyme complex (MEC) of metabolically activated enzymes composed of proteases, amylases, lipases, alpha galactosidase, and glucoamylase from natural sources. These enzymes are encapsulated in an SK713 SLP (non‐GMO soy lecithin phospholipid) absorption technology (‘Prodosome ® ’). Objective This randomized double‐blind placebo‐controlled investigation assessed the safety and efficacy of Prodosomed N‐Sorb KD120 MEC on various parameters of the blood, immunity, body composition, physical health, and quality of life in young healthy male and female subjects over a 90‐day period. Methods Institutional Review Board Approval was obtained from University of Wyoming School of Pharmacy, Laramie, WY. Forty‐six young male and female (mean age: 25.8 ± 12.1 years) healthy volunteers, were randomly assigned to receive either N‐SORB (1 mL, twice daily) or placebo over a period of 90 consecutive days. Complete blood count as well as blood glucose, liver enzymes, and lipid profile were assessed pre‐ and post‐intervention. Serum cytokine levels were determined by using a Bio‐Plex Pro Human Cytokine 8‐plex Assay. Whole body composition analysis was performed by dual‐energy X‐Ray absorptivity (DEXA) to determine body fat mass, lean mass and android and gynoid fat. Body, weight, blood pressure, and physical health were assessed. WHOQOL‐BREF and a Pittsburgh Sleep Quality Index (PSQI) questionnaires were used for quality of life and sleep quality assessments respectively. Adverse events were monitored before, during and after the completion of the study. Results Of the 46 subjects enrolled, 41 subjects successfully completed the trial. Compared to placebo, changes in blood cell counts including hematocrit, hemoglobin, mean corpuscular volume, platelets and lymphocytes provide evidence of consistent improvement, which were reconfirmed by Quality of Life (QOL) parameters that significantly improved in the N‐SORB group. No significant changes in BUN, serum creatinine, ALP, AST, ALT, and lipid profile were observed between the placebo and treatment groups. No adverse reports were reported. Conclusion This randomized, double blind, placebo‐controlled clinical study demonstrates that short‐term intervention with N‐SORB improves the QOL in young healthy volunteers and didn't alter cardiometabolic parameters, lipid profile or body composition. Subjects receiving N‐SORB reported an overall improvement in quality of life. Support or Funding Information The Study was Partially Supported by VNI Inc, Lederach, FL This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Constitutional telomerase mutations are genetic risk factors for cirrhosis (2011)

Most TERT gene variants reduced telomerase enzymatic activity in vitro. Loss-of-function telomerase gene variants associated with short telomeres are risk factors for sporadic cirrhosis.
Modification of conditions for the selective preparation of 2-amino-3-cyano-4-phenylpyridines (2011)

We herein describe the modification of the experimental conditions for the synthesis of certain 2amino-4-aryl-3-cyanopyridines from benzaldehyde, malononitrile, ammonium acetate and aminoketones. The outcome of the reaction proved to be highly dependent on the experimental procedure, occasionally giving rise to metaphthalodinitriles. Mechanistical proposals are also reported, in order to explain the observed dependence on the procedure.
Gut Microbiota, Intestinal Permeability, Obesity‐Induced Inflammation, and Liver Injury (2011)

Obesity and its metabolic complications are major health problems in the United States and worldwide, and increasing evidence implicates the microbiota in these important health issues. Indeed, it appears that the microbiota function much like a metabolic "organ," influencing nutrient acquisition, energy homeostasis, and, ultimately, the control of body weight. Moreover, alterations in gut microbiota, increased intestinal permeability, and metabolic endotoxemia likely play a role in the development of a chronic low-grade inflammatory state in the host that contributes to the development of obesity and associated chronic metabolic diseases such as nonalcoholic fatty liver disease. Supporting these concepts are the observations that increased gut permeability, low-grade endotoxemia, and fatty liver are observed in animal models of obesity caused by either high-fat or high-fructose feeding. Consistent with these observations, germ-free mice are protected from obesity and many forms of liver injury. Last, many agents that affect gut flora/permeability, such as probiotics/prebiotics, also appear to affect obesity and certain forms of liver injury in animal model systems. Here the authors review the role of the gut microbiota and metabolic endotoxemia-induced inflammation in the development of obesity and liver injury, with special reference to the intensive care unit setting.
Microarray Analysis of the <i>Mycobacterium tuberculosis</i> Transcriptional Response to the Acidic Conditions Found in Phagosomes (2002)

We used microarrays and real-time reverse transcription-PCR to analyze the global transcriptional response of Mycobacterium tuberculosis to low pH in vitro, which may mimic an environmental signal encountered by phagocytosed mycobacteria. Eighty-one genes were differentially expressed >1.5-fold, including many involved in fatty acid metabolism. The most highly induced genes showed homology with nonribosomal peptide synthetases/polyketide synthases.
Treatment of the Immune-Related Adverse Effects of Immune Checkpoint Inhibitors (2016)

The clinical use of immune checkpoint inhibitors is expanding rapidly. Oncology practitioners will therefore be required to recognize and manage irAEs in a growing patient population. Early recognition and treatment are essential to prevent patient morbidity and mortality, and adherence to established algorithms is recommended.
Facile Fabrication of Hybrid Colloidosomes with Alginate Gel Cores and Shells of Porous CaCO<sub>3</sub> Microparticles (2007)

Come together: Porous CaCO3 microparticles self-assemble to form shells at the interfaces of water-in-oil emulsion droplets. Water cores containing alginate are subsequently gelated in situ by Ca2+, which is released from the CaCO3 microparticles when the pH value is lowered. As the picture shows, the CaCO3 microparticle shell of the hydrogel bead can be seen under polarized light. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2267/2007/z700147_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
ChemInform Abstract: Synthesis and Antimalarial Activity of a Series of 2,4‐Diamino‐6‐((Nalkylanilino)methyl)quinazolines. (1987)

Abstract The aminocyanotoluene (IIb), prepared from (I), is cyclized with cyanoguanidine (III) to produce the quinazolines (IV) which are converted to the aminomethyl derivatives (VIII) as shown in the reaction scheme.
Expression and Modulation of Voltage-Gated Calcium Channels After RNA Injection in <i>Xenopus</i> Oocytes (1986)

Calcium ions flow into cells through several distinct classes of voltage-dependent calcium-selective channels. Such fluxes play important roles in electrical signaling at the cell membrane and in chemical signaling within cells. Further information about calcium channels was obtained by injecting RNA isolated from rat brain, heart and skeletal muscle into Xenopus oocytes. Macroscopic currents through voltage-operated calcium channels were resolved when the endogenous calcium-dependent chloride current was blocked by replacing external calcium with barium and chloride with methanesulfonate. The resulting barium current was insensitive to tetrodotoxin but was completely blocked by cadmium or cobalt. With both heart and brain RNA at least two distinct types of calcium ion conductance were found, distinguishable by their time course and inactivation properties. In oocytes injected with heart RNA, the slowly inactivating component was selectively blocked by the calcium-channel antagonist nifedipine. Barium ion currents induced by heart RNA were modulated by isoproterenol, cyclic adenosine monophosphate, and acetylcholine.