gebhart/patrepeval huggingface dataset:
ELECTROKINETIC ASPECTS OF SURFACE CHEMISTRY. IV: The Ratio of Electroösmosis to Electrophoresis (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTELECTROKINETIC ASPECTS OF SURFACE CHEMISTRY. IV: The Ratio of Electroösmosis to ElectrophoresisLAURENCE S. MOYERLAURENCE S. MOYERMore by LAURENCE S. MOYERCite this: J. Phys. Chem. 1938, 42, 3, 391–395Publication Date (Print):March 1, 1938Publication History Published online1 May 2002Published inissue 1 March 1938https://doi.org/10.1021/j100898a008RIGHTS & PERMISSIONSArticle Views29Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (261 KB) Get e-Alerts
Instruction set design and optimizations for address computation in DSP architectures (1996)

In this paper we investigate the problem of code generation for address computation for DSP processors. This work is divided into four parts. First, we propose a branch instruction design which can guarantee minimum overhead for programs that make use of implicit indirect addressing. Second, we give a formulation and propose a solution for the problem of allocating address registers (ARs) for array accesses within loop constructs. Third, we describe retargetable approaches for auto-increment (decrement) optimizations of pointer variables, and loop induction variables. Finally, we use a graph coloring technique to allocate physical ARs to the virtual ARs used in the previous phases. The results show that the combination of the above techniques considerably improves the final code quality for benchmark DSP programs.
Potential protective effect of HSCAS and bentonite against dietary aflatoxicosis in rat: with special reference to chromosomal aberrations (1998)

Bentonite and hydrated sodium calcium aluminsilicate (HSCAS) were added at a level of 0.5% (w/w) to the diets containing 2.5 mg aflatoxins (AF) per kg diet and fed to male mature rats for 15 successive days. Aflatoxin alone significantly decreased feed intake and altered serum biochemical parameters of liver and kidney functions. Aflatoxin caused chromosomal aberrations in bone marrow cells. Bentonite or HSCAS did not alter any of the parameters measured. The addition of bentonite or HSCAS to the AF-contaminated diet diminished most of the deleterious effects of the aflatoxin. Pathological examinations of liver and kidney proved that both bentonite and HSCAS were hepatonephroprotective agents against aflatoxicosis. The cytogenetic findings demonstrated that the addition of bentonite or HSCAS to AF-contaminated diet suppressed chromosomal aberrations. These findings indicated that bentonite and HSCAS could diminished many of the adverse effect of dietary AF in rats.
Various 5-substituted and 2,5-disubstituted 1,3-dioxanes, a new class of analgesic agents (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVarious 5-substituted and 2,5-disubstituted 1,3-dioxanes, a new class of analgesic agentsRichard N. Booher, Stephen E. Smits, William W. Turner Jr., and Albert PohlandCite this: J. Med. Chem. 1977, 20, 7, 885–890Publication Date (Print):July 1, 1977Publication History Published online1 May 2002Published inissue 1 July 1977https://pubs.acs.org/doi/10.1021/jm00217a003https://doi.org/10.1021/jm00217a003research-articleACS PublicationsRequest reuse permissionsArticle Views240Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Disassembling the complexity of mucus barriers to develop a fast screening tool for early drug discovery (2019)

Mucus is a natural barrier with a protective role that hinders drug diffusion, representing a steric and interactive barrier to overcome for an effective drug delivery to target sites. In diseases like cystic fibrosis (CF), pulmonary mucus exhibits altered features, which hamper clearance mechanisms and drug diffusion, ultimately leading to lung failure. Effectively modelling the passage through mucus still represents an unmet challenge. An airway CF mucus model is herein proposed to disassemble the complexity of the mucus barrier following a modular approach. A hydrogel, mainly composed of mucin in an alginate (Alg) network, is proposed to specifically model the chemical-physical properties of CF mucus. The steric retention of pathological mucus was reproduced by targeting its mesh size (approximately 50 nm) and viscoelastic properties. The interactive barrier was reproduced by a composition inspired from the CF mucus. Optimized mucus models, composed of 3 mg ml-1 Alg and 25 mg ml-1 mucin, exhibited a G' increasing from ∼21.2 to 55.2 Pa and a G'' ranging from ∼5.26 to 28.8 Pa in the frequency range of 0.1 to 20 Hz. Drug diffusion was tested using three model drugs. The proposed mucus model was able to discriminate between the mucin-drug interaction and the steric barrier of a mucus layer with respect to the parallel artificial membrane permeability (PAMPA) that models the phospholipidic cell membrane, the state-of-the-art screening tool for passive drug diffusion. The mucus model can be proposed as an in vitro tool for early drug discovery, representing a step forward to model the mucus layer. Additionally, the proposed methodology allows to easily include other molecules present within mucus, as relevant proteins, lipids and DNA.
Structural insights into NusG regulating transcription elongation (2016)

NusG is an essential transcription factor that plays multiple key regulatory roles in transcription elongation, termination and coupling translation and transcription. The core role of NusG is to enhance transcription elongation and RNA polymerase processivity. Here, we present the structure of Escherichia coli RNA polymerase complexed with NusG. The structure shows that the NusG N-terminal domain (NGN) binds at the central cleft of RNA polymerase surrounded by the β' clamp helices, the β protrusion, and the β lobe domains to close the promoter DNA binding channel and constrain the β' clamp domain, but with an orientation that is different from the one observed in the archaeal β' clamp-Spt4/5 complex. The structure also allows us to construct a reliable model of the complete NusG-associated transcription elongation complex, suggesting that the NGN domain binds at the upstream fork junction of the transcription elongation complex, similar to σ2 in the transcription initiation complex, to stabilize the junction, and therefore enhances transcription processivity.
Detection of Multidrug Resistance (<i>MDR</i>1) Gene RNA Expression in Human Tumors by a Sensitive Ribonuclease Protection Assay (1989)

The human MDR1 gene encoding P-glycoprotein, an energy-dependent drug-efflux pump, was initially isolated from a multidrug-resistant KB carcinoma cell. When a 3 kb genomic sequence isolated from normal human tissue including the major downstream promoter and the first and second exons of the MDR1 gene was compared to the equivalent fragment from KB cells, the MDR1 gene from KB carcinoma cells was found to have a point mutation in the first exon. Although this mutation does not affect the downstream promoter sequence or the coding sequence of the MDR1 gene, it creates a single base mismatch between the 5' KB genomic fragment previously used for RNase protection analysis of MDR1 RNA expression in normal tissues and thereby reduces the sensitivity of this assay. Using the DNA fragment from normal tissues rather than KB cells, we have reanalyzed MDR1 mRNA levels in 12 renal carcinomas and 4 colon adenocarcinomas. By this RNase protection assay, MDR1 RNA levels are as high in these tumors as in the multidrug-resistant cell line, KB-8-5. The ribonuclease protection assay indicated that the major downstream promoter was mainly used in these clinical samples including two samples of RNA from metastatic renal cancer. This assay appears to be a very sensitive and specific assay for detecting MDR1 mRNA levels and mRNA initiation sites in clinical samples.
Tangible User Interfaces (TUIs): A Novel Paradigm for GIS (2004)

Abstract In recent years, an increasing amount of effort has gone into the design of GIS user interfaces. On the one hand, Graphical User Interfaces (GUIs) with a high degree of sophistication have replaced line‐driven commands of first‐generation GIS. On the other hand, a number of alternative approaches have been suggested, most notably those based on Virtual Environments (VEs). In this paper we discuss a novel interface for GIS, which springs from recent work carried out in the field of Tangible User Interfaces (TUIs). The philosophy behind TUIs is to allow people to interact with computers via familiar tangible objects, therefore taking advantage of the richness of the tactile world combined with the power of numerical simulations. Two experimental systems, named Illuminating Clay and SandScape , are described here and their applications to GIS are examined. Conclusions suggest that these interfaces might streamline the landscape design process and result in a more effective use of GIS, especially when distributed decision‐making and discussion with non‐experts are involved.
Analysis and Design Techniques for Supply-Noise Mitigation in Phase-Locked Loops (2010)

Supply noise affects the jitter performance of ring oscillator-based phase-locked loops (PLLs) significantly. While the focus of much of the prior art is on supply noise in oscillators, this paper illustrates that supply noise in other building blocks also contribute significantly to PLL output jitter. Analytical expressions for supply-noise sensitivities are derived for each of the circuit blocks used in the PLL and insight into the mechanism through which supply noise appears at the PLL output is provided. Efficient supply-regulation schemes that combine a split-tuned PLL architecture with an optimized low-dropout regulator to achieve better than -22 dB of worst case supply-noise sensitivity for the whole PLL are presented. Fabricated in a 0.18 μm digital CMOS process, the prototype PLL occupies an area of 0.18 μm and operates from a 1.8 V supply. At 1.5 GHz, the total power consumption is 3.3 mW, of which 0.54 mW is consumed in the regulators. The measured output peak-to-peak jitter is 33 ps and 41 ps with no supply noise and with a 100-mV amplitude supply noise tone injected at the worst case noise frequency, respectively.
Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer (2001)

SBA2 gene might be a promising novel biomarker of cell differentiation in colorectal cancer and its biological features need further studies.
Improved detection of P53 mutations in soft tissue tumors using new gel composition for automated nonradioactive analysis of single‐strand conformation polymorphism (1997)

We report a new nonradioactive method to detect sequence changes, including single-base substitutions through shifts in electrophoretic mobility using an automated fluorescence sequencer (ALFexpress, Pharmacia, Biotech) connected to external cooling equipment. Single strands were identified by incorporation of fluorescein-labeled primers during amplification and subsequent laser detection at the bottom of the gel. The amplified polymerase chain reaction (PCR) products were heat-denatured and loaded onto a polyacrylamide gel under nondenaturing conditions and strict control of constant low temperature. Peak shifts in the fluorogram indicated mutations. A novel gel composition improved the detection rate for mutations considerably. Automatic analysis of single-strand conformation polymorphism (SSCP) gels saves time and costs, and is highly reproducible. The method was applied for mutation screening in exon 7 of the p53 tumor suppressor gene in DNA of freshly frozen soft tissue tumors. The mutation spectrum and frequency in exon 7 of the p53 gene are discussed with respect to oncogenesis in soft tissue sarcomas.
Estimation of Aedes aegypti (Diptera: Culicidae) population size and adult male survival in an urban area in Panama (2014)

Traditional mosquito control strategies rely heavily on the use of chemical insecticides. However, concerns about the efficiency of traditional control methods, environmental impact and emerging pesticide resistance have highlighted the necessity for developing innovative tools for mosquito control. Some novel strategies, including release of insects carrying a dominant lethal gene (RIDL®), rely on the sustained release of modified male mosquitoes and therefore benefit from a thorough understanding of the biology of the male of the species. In this report we present the results of a mark-release-recapture study aimed at: (i) establishing the survival in the field of laboratory-reared, wild-type male Aedes aegypti and (b) estimating the size of the local adult Ae. aegypti population. The study took place in Panama, a country where recent increases in the incidence and severity of dengue cases have prompted health authorities to evaluate alternative strategies for vector control. Results suggest a life expectancy of 2.3 days for released male mosquitoes (confidence interval: 1.78-2.86). Overall, the male mosquito population was estimated at 58 males/ha (range 12-81 males/ha), which can be extrapolated to an average of 0.64 pupae/person for the study area. The practical implications of these results are discussed.
Further characterization of the in vitro tumoricidal activity of staphylococcal protein A. (1986)

Treatment of plasma or serum from leukemic patients with solid phase staphylococcal Protein A induced leukemic blast cell lysis in vitro, but this effect was relatively independent of the amount of immunoglobulin G (IgG) removed. Samples with approximately equal cytotoxic activity contained markedly different IgG levels, while samples with similar IgG levels had a wide range of tumoricidal activity. Assays of plasma samples collected during a perfusion of one plasma volume through a Protein A-Sepharose column indicated that the duration of the procedure had a greater effect on cytotoxic activity than did the amount of IgG removed. Neither added leukemic nor normal IgG significantly improved blast cell viability in treated serum. Cytotoxic activity was not dialyzable and concentrated in the Mr less than 100,000 fraction of samples separated by filtration. Treated cytotoxic serum samples did not have important Clq binding activity. These results suggest that the in vitro tumoricidal activity of solid phase Protein A is probably due to a toxic substance added to serum during immunoadsorption rather than to its immunoadsorptive capacity.
Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model (1995)

The growth and development of the endocrine pancreas has been studied for many years, but questions remain concerning the regulation of the mass of insulin-producing beta-cells both in the normal growing pancreas and during the pathogenesis of diabetes. The homeostatic control of beta-cell mass in both normal and pathophysiological conditions is based on the balance of cell proliferation, cell growth, and cell death. To gain insight into the relative contribution of each of these dynamic processes, we first mathematically analyzed the data available on the components involved in the maintenance of beta-cell mass, including rates of replication, beta-cell volume, and the beta-cell mass itself, at various ages in normal Sprague-Dawley rats. Then these data were combined in a simple mass balance equation to construct a mathematical model of the dynamics of the beta-cell mass in the normal growing rat pancreas. Such a model has allowed us to infer the contributions of fluxes that cannot be measured, i.e., neogenesis and cell death, to the known mass of beta-cells. Another important contribution of this model is to raise unanswered questions concerning the control of the balance of cell death and cell renewal in the endocrine pancreas.
Composition and Temperature Dependence of the Pitch in Cholesteric Binary Mixtures (1977)

Abstract In the cholesteric phase of mixtures of cholesteric cholesteryl chloride (CC) with nematic p-ethoxy benzylidene-p-n butylaniline (EBBA) as well as with nematic p-[(p-ethoxy-benzyl-idene)amino]benzonitrile (PEBAB), the pitch has been determined asl a function of temperature and composition. For a CC weight fraction x≲ 0.8 we used the “variable wedge” method for x ≳ 0.8 we determined the wavelength of maximum reflection λo and the average refractive index n and employed the rlation λo = n p. We show that n can vary appreciably as a function of composition in a cholesteric binaryo system. For each composition the reciprocal pitch can be fitted reasonably well to a linear function of the temperature, except in the vicinity of phase transitions. It appears that the slope of the linear function, i.e. d(p−1/dt, is always positive. We dicuss the results in relation to recently developecd expressions for the pitch as a function of temperature and composition.
Electroluminescence of β-FeSi<sub>2</sub> Light Emitting Devices (2001)

Ion beam synthesised β-FeSi 2 light emitting devices have been fabricated by ion implantation of iron into pre-grown abrupt silicon p–n junctions. Several samples were fabricated by varying the implant conditions and the junction characteristics (layer thickness and doping concentration). Light emission at ∼1.5 µm was obtained from all devices but the intensity decreased with increasing temperature. The electroluminescence quenching was found to depend on both the iron implant conditions and the characteristics of the p–n junction.
Neutral bremsstrahlung measurement in an atmospheric-pressure radio frequency discharge (2000)

Neutral bremsstrahlung emission spectrum is measured in an atmospheric-pressure radio frequency (rf) capacitive discharge for a gas mixture of helium (99.5%) and oxygen (0.5%) using a high resolution triple monochromator between 450 and 1000 nm. Good agreement is obtained for spectral variation and absolute intensity between the observed neutral bremsstrahlung and theoretical emissivity calculated using electron–neutral momentum cross sections. Based on a theoretical fitting, the discharge is characterized by a time averaged electron density of 2.9×1011 cm−3 and an electron temperature of 1.9 eV for an input power density of 28 W/cm3.
Association Between Iodinated Contrast Media Exposure and Incident Hyperthyroidism and Hypothyroidism (2012)

Iodinated contrast media exposure is associated with subsequent development of incident hyperthyroidism and incident overt hypothyroidism.
Iterative Arrays of Logical Circuits (1961)

An exploration of the techniques for analyzing the behavior of one- and two-dimensional iterative networks formed of discrete, or logical elements, showing that most questions about the behavior of iterative systems are recursively undecidable.
Powder Metallurgical Processing of Tb<sub>0.27</sub>Dy<sub>0.73</sub>Fe<sub>2−<i>x</i> </sub>(0.5 ≥ <i>x</i> ≥ 0.1) from Fine Hydride Powder* (1994)

Article Powder Metallurgical Processing of Tb0.27Dy0.73Fe2−x(0.5 ≥ x ≥ 0.1) from Fine Hydride Powder* was published on January 1, 1994 in the journal Zeitschrift für Physikalische Chemie (volume 183, issue 1-2).
59‐4: <i>Invited Paper:</i> Electro‐optical size‐dependence investigation in GaN micro‐LED devices (2018)

High brightness and ultra‐high resolution GaN micro‐displays are starting to emerge as a promising technology. We present in this paper the µLED electro‐optical performances with regards to their size. Electroluminescence results and ABC model based simulations will be presented and analysed. We show through different results on our fabricated device, that the size‐dependent electrical and optical µLED performance is still a challenge to unravel and address.
CRC Desk Reference for Nutrition (2005)

Following in the tradition of its popular predecessor, the CRC Desk Reference for Nutrition, Second Edition explains hundreds of terms commonly used in medicine, food science, metabolism, physiology, and nutrition. Thoroughly updated and expanded to reflect major advances over the past decade, this reference lists entries alphabetically and even cr
Patchwork-Based Audio Watermarking Method Robust to De-synchronization Attacks (2014)

This paper presents a patchwork-based audio watermarking method to resist de-synchronization attacks such as pitch-scaling, time-scaling, and jitter attacks. At the embedding stage, the watermarks are embedded into the host audio signal in the discrete cosine transform (DCT) domain. Then, a set of synchronization bits are implanted into the watermarked signal in the logarithmic DCT (LDCT) domain. At the decoding stage, we analyze the received audio signal in the LDCT domain to find the scaling factor imposed by an attack. Then, we modify the received signal to remove the scaling effect, together with the embedded synchronization bits. After that, watermarks are extracted from the modified signal. Simulation results show that at the embedding rate of 10 bps, the proposed method achieves 98.9% detection rate on average under the considered de-synchronization attacks. At the embedding rate of 16 bps, it can still obtain 94.7% detection rate on average. So, the proposed method is much more robust to de-synchronization attacks than other patchwork watermarking methods. Compared with the audio watermarking methods designed for tackling de-synchronization attacks, our method has much higher embedding capacity.
Chronic vasomotor rhinitis: Cryogenic and other surgical modes of treatment (1979)

Cryosurgical treatment of chronic vasomotor rhinitis provides a safe, effective and uncomplicated mode of management for this very common otolaryngologic disorder. Data relating to three hundred fifty patients is presented with particular reference to patient selection criteria, cryosurgical techniques and results.