gebhart/patrepeval huggingface dataset:
Prevalence and Duration of Hot Flushes After Surgical or Medical Castration in Men with Prostatic Carcinoma (1994)

A total of 77 men with prostatic carcinoma treated with orchiectomy or a gonadotropin releasing hormone analogue before September 1987 underwent evaluation by a questionnaire regarding vasomotor symptoms. Answers were received from 84% of the patients. Of 63 patients 43 (68%) reported hot flushes during treatment, while 30 (48%) still had flushes 5 years after treatment. Of the latter 30 patients 28 (median 7.6 years after treatment) had vasomotor symptoms at the time of the study. Only 13 of 43 men with vasomotor symptoms after the start of treatment had relief 5 years later. At the time of the study 13 of 30 patients (more than 40%) still had flushes 8 years after castration. Most men reported that the flushes presently had the same frequency and duration as when they started therapy. Contrary to the general belief that the symptoms disappear with time, our study highlighted a long persistence of hot flushes after castration.
The dose makes the poison (1984)

The dose makes the poison , The dose makes the poison , کتابخانه مرکزی دانشگاه علوم پزشکی ایران
Geometric confinement influences cellular mechanical properties I -- adhesion area dependence. (2007)

Interactions between the cell and the extracellular matrix regulate a variety of cellular properties and functions, including cellular rheology. In the present study of cellular adhesion, area was controlled by confining NIH 3T3 fibroblast cells to circular micropatterned islands of defined size. The shear moduli of cells adhering to islands of well defined geometry, as measured by magnetic microrheometry, was found to have a significantly lower variance than those of cells allowed to spread on unpatterned surfaces. We observe that the area of cellular adhesion influences shear modulus. Rheological measurements further indicate that cellular shear modulus is a biphasic function of cellular adhesion area with stiffness decreasing to a minimum value for intermediate areas of adhesion, and then increasing for cells on larger patterns. We propose a simple hypothesis: that the area of adhesion affects cellular rheological properties by regulating the structure of the actin cytoskeleton. To test this hypothesis, we quantified the volume fraction of polymerized actin in the cytosol by staining with fluorescent phalloidin and imaging using quantitative 3D microscopy. The polymerized actin volume fraction exhibited a similar biphasic dependence on adhesion area. Within the limits of our simplifying hypothesis, our experimental results permit an evaluation of the ability of established, micromechanical models to predict the cellular shear modulus based on polymerized actin volume fraction. We investigated the "tensegrity", "cellular-solids", and "biopolymer physics" models that have, respectively, a linear, quadratic, and 5/2 dependence on polymerized actin volume fraction. All three models predict that a biphasic trend in polymerized actin volume fraction as a function of adhesion area will result in a biphasic behavior in shear modulus. Our data favors a higher-order dependence on polymerized actin volume fraction. Increasingly better experimental agreement is observed for the tensegrity, the cellular solids, and the biopolymer models respectively. Alternatively if we postulate the existence of a critical actin volume fraction below which the shear modulus vanishes, the experimental data can be equivalently described by a model with an almost linear dependence on polymerized actin volume fraction; this observation supports a tensegrity model with a critical actin volume fraction.
Inflammatory Cytokines and Spontaneous Preterm Birth in Asymptomatic Women (2010)

Inflammatory cytokine IL-6 in cervicovaginal fluid and IL-6 and CRP in amniotic fluid but not in plasma are strongly associated with spontaneous preterm birth in asymptomatic women, suggesting that inflammation at the maternal-fetal interface, rather than systemic inflammation, may play a major role in the etiology of such spontaneous preterm births.
A SAT-based preimage analysis of reduced KECCAK hash functions. (2010)

Abstract In this paper, we present a preimage attack on reduced versions of Keccak hash functions. We use our recently developed toolkit CryptLogVer for generating the conjunctive normal form, CNF, which is passed to the SAT solver PrecoSAT. We found preimages for some reduced versions of the function and showed that full Keccak function has a comfortable security margin against this kind of attack.
The Auger Electron Dosimetry of Indium-111 in Mammalian Cells in Vitro (1989)

Most of the radionuclides used in the formulation of radiopharmaceuticals emit Auger electrons when they undergo radioactive decay. The release of these low-energy electrons at extracellular sites produces little direct damage to intracellular structures. However, many radiopharmaceuticals, or their metabolites, can be transported into the cell where the Auger electrons have the potential to damage nearby intracellular macromolecules, including DNA. In this preliminary study, chromosome damage, expressed as 60Co equivalent doses, and the effects on cell division following treatment with intracellular and extracellular 111In were measured in Chinese hamster V79 cells. The chromosome aberration yield in cells irradiated by intracellular 111In indicated that damage was induced at a rate of 7.2 X 10(-4) Gy/decay for levels of activity up to 0.075 Bq/cell and 4.5 X 10(4) and 2.9 X 10(4) Gy/decay for intermediate (0.204 Bq/cell) and high (0.389 Bq/cell) levels, respectively. Extracellular 111In-chloride produced damage at a rate of about 6.1 X 10(-12) Gy/decay. As little as 4.4 mBq/cell (about 4.4 X 10(3) Bq/ml of culture) of intracellular 111In was able to affect cell division, whereas extracellular 111In at 1.150 MBq/ml of culture had little effect. These data indicate that the Medical Internal Radiation Dose and International Committee on Radiation Units methods for organ dosimetry may underestimate the potential of intracellular Auger electron emitters to produce radiation damage.
Antineoplaston A in cancer therapy. (I). (1977)

Twenty-one patients with advanced cancer or leukemia were treated with antineoplaston A and followed for up to nine months. Dosage by intravenous, intramuscular, subcutaneous, rectal, intrapleural, intravesical and/or topical administration ranged from 0.6 to 33 U/m2/24 h. Treatment was well tolerated, although side effects included fever of short duration and elevation of platelet and white blood count. In 18 cases some degree of clinical improvement was observed. Complete remission occurred in 4 cases. More than 50% remission occurred in 4 other cases which, along with another 6 cases, are continuing the treatment with high doses of antineoplaston A and show a continuing regression of the tumors although not yet achieving the criteria for complete remission; 2 of these 6 cases seem unlikely to achieve remission. Two patients temporarily discontinued treatment. During treatment, 5 patients expired; in 2 of them, however, was seen significant regression of the neoplastic process. The deaths were not due to cancer or to any toxicity incurred by the treatment.
Molecular characterization and assembly of the needle complex of the <i>Salmonella typhimurium</i> type III protein secretion system (2000)

Many bacterial pathogens of plants and animals have evolved a specialized protein-secretion system termed type III to deliver bacterial proteins into host cells. These proteins stimulate or interfere with host cellular functions for the pathogen's benefit. The Salmonella typhimurium pathogenicity island 1 encodes one of these systems that mediates this bacterium's ability to enter nonphagocytic cells. Several components of this type III secretion system are organized in a supramolecular structure termed the needle complex. This structure is made of discrete substructures including a base that spans both membranes and a needle-like projection that extends outward from the bacterial surface. We demonstrate here that the type III secretion export apparatus is required for the assembly of the needle substructure but is dispensable for the assembly of the base. We show that the length of the needle segment is determined by the type III secretion associated protein InvJ. We report that InvG, PrgH, and PrgK constitute the base and that PrgI is the main component of the needle of the type III secretion complex. PrgI homologs are present in type III secretion systems from bacteria pathogenic for animals but are absent from bacteria pathogenic for plants. We hypothesize that the needle component may establish the specificity of type III secretion systems in delivering proteins into either plant or animal cells.
Recent Advances in the Total Synthesis of Piperidine and Pyrrolidine Natural Alkaloids with Ring‐Closing Metathesis as a Key Step (2003)

Abstract This microreview focuses on recent applications of the ring‐closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids. The most recent examples are described, from simple piperidine alkaloids to complex pentacyclic structures such as (+)‐tabersonine. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
New Development in Subsea Production – The Modular Manifold Concept (1980)

Abstract Offshore development of oil or gas fields in deep waters (up to 1 000 m) involves floating facilities for process, subsea wellheads and connection between them by riser and manifold. Many technical problems arise amongst which two can be easily solved by a modular manifold concept : they are flowline connection and maintenance of subsea equipment. The basic idea of the concept is to split the manifold in modules which are recoverable and whose functions are: – control of the production – connect one flowline, already laid and positioned with the manifold The installation of the module is performed with drill pipe and hydraulic handling tool; all control equipment such as valves, connectors, hydraulic devices, are located on the module and can be easily serviced at surface; the geometry of the module is adapted to T.F.L. technique. A prototype of such an equipment is presently built in France and sea trials of the concept including flowline connection on the manifold will be performed during winter 80/81.
Bor‐Stickstoff‐Verbindungen, XIX: Einige neue Aminoborane (1965)

Abstract Im Zuge der Darstellung einiger neuer Aminoborane wird bei der Grignard‐Reaktion von Dihalogenaminoboran, R 2 NBX 2 , ein Halogenorganoaminoboran, R 2 NBXR′, erhalten. Die Spaltung einer BC‐Bindung durch Triäthylsilylamin während einer Transaminierungsreaktion wird beschrieben.
Acute inflammatory proteins constitute the organic matrix of prostatic corpora amylacea and calculi in men with prostate cancer (2009)

Corpora amylacea (CA) are a frequent microscopic finding in radical prostatectomy specimens from men undergoing treatment for prostate cancer. Although often observed histologically to be associated with inflammation, the contribution of CA to prostatitis-related symptoms of unknown etiology or to prostate carcinogenesis remains unclear. Prostatic calculi (PC), which potentially represent calcified forms of CA, are less common but can cause urological disease including urinary retention and prostatitis. We conducted a comprehensive compositional analysis of CA/PC to gain insight into their biogenesis. Infrared spectroscopy analysis of calculi collected from 23 patients confirmed a prevalence of calcium phosphate in the form of hydroxyapatite. This result sets PC apart from most urinary stones, which largely are composed of calcium oxalate. Tandem mass spectrometry-based proteomic analysis of CA/PC revealed that lactoferrin is the predominant protein component, a result that was confirmed by Western blot analysis. Other proteins identified, including calprotectin, myeloperoxidase, and alpha-defensins, are proteins contained in neutrophil granules. Immunohistochemistry (IHC) suggested the source of lactoferrin to be prostate-infiltrating neutrophils as well as inflamed prostate epithelium; however, IHC for calprotectin suggested prostate-infiltrating neutrophils as a major source of the protein, because it was absent from other prostate compartments. This study represents a definitive analysis of the protein composition of prostatic CA and calculi and suggests that acute inflammation has a role in their biogenesis--an intriguing finding, given the prevalence of CA in prostatectomy specimens and the hypothesized role for inflammation in prostate carcinogenesis.
A Controlled Trial of High-Intensity Double-Surface Phototherapy on a Fluid Bed Versus Conventional Phototherapy in Neonatal Jaundice (1995)

HIDS phototherapy on the fluid bed is significantly more effective in reducing bilirubin than CPT. It can be easily and economically provided using equipment currently available in most neonatal units.
Uncertainties in transport theory pressure vessel neutron fluence calculations (1996)

The desire for increasing safety margins (increased power production and plant availability), the fact that many existing plants are approaching the final years of their design lifetime, and the consideration of life extension have resulted in the need for performing more accurate estimation of parameters that affect plant performance and safety. This means that more accurate calculational and experimental methodologies for estimating the neutron and/or gamma fluence distributions are needed to ensure the structural integrity of the pressure vessel in pressurized water reactors (PWRs) and vessel internals in boiling water reactors. Such an estimation requires the use of particle transport theory methods and analysis; because of the existing uncertainties in the input parameters and numerical methods, it is necessary to estimate the uncertainties in the calculated results.
Properties of biologically formed manganese oxide in relation to soil manganese (1978)

Manganese oxide, produced from the oxidation of manganous ions by bacteria at pH 6.5, was extracted with solutions commonly used to estimate the availability of soil manganese to plants. Reducing agents at pH 7.0 completely dissolved the manganese oxide as did sodium ethylene diaminetetra-acetate (EDTA) solutions more acid than pH 6.0. Other acidic solutions extracted part of the manganese in amounts in proportion to the amount of oxide present. Neutral salts extracted only traces of manganese; however, the addition of copper or zinc salts to neutral M ammonium acetate resulted in the release of appreciable amounts of manganese from the oxide. The fact that sodium EDTA solutions and solutions containing copper and zinc released manganese from the bacterial manganese oxide indicates that the practice of extracting soils with these solutions to estimate of organically bound manganese is unsound. The oxide, when pre-heated from 50 to 108°C, became progressively more soluble in neutral M ammonium acetate. Manganese was also rapidly released when the pH of the oxide in suspension was lowered from pH 7 to pH 4. Conversely the oxide rapidly adsorbed manganous ions as the pH was raised from pH 4 to 7. These changes in manganese solubility parallel those reported for soils receiving similar treatments, and it is postulated that the active manganese oxides in soil are similar to bacterial manganese oxide. It is also suggested that the acid-replaceable manganese associated with the oxide plays an important part in the availability of manganese in soils.
Imaging Findings in Neonatal Hypoxia: A Practical Review (2008)

Imaging findings in term neonates must be assessed according to different rules from those used in other age groups. Four major signs are proposed as a means of facilitating the diagnosis of hypoxia in the neonate.
The Formation of High-boiling By-products in the Isomerization and Disproportionation of <i>m</i>-Xylene over a Silica-alumina Catalyst under Pressure (1972)

Abstract Continuous liquid-phase isomerization and disproportionation reactions over silica-alumina catalysts were carried out using m-xylene with varying concentration of water. The reactions were conducted at 290°C and 400°C under a pressure of 300 kg/cm2. The results showed that the concentration of water required to attain a maximum activity for the isomerization was higher than that needed for the disproportionation reaction. The high-boiling by-products produced at 400°C comprized 2–5 per-cent of the weight of the total products, and the main component, polymethyldiphenylmethane, amounted to 70–80 per-cent of the by-products. The yield of polymethyldiphenylmethane was linearly correlated with that of toluene. This result appears to suggest that the disproportionation reaction and the polymethyldiphenylmethane formation proceed at a common active site and through the same intermediate.
Collision detection for clothed human animation (2002)

We present a voxel-based collision detection method for clothed human animation. We speed up the performance of the voxel-based method by choosing an appropriate voxel size and using a fast voxelization approach. Based on the voxel method, we propose a self-collision detection method and a simplified collision detection method. First, the efficiency of self-collision detection is improved by taking advantage of the curvature and multi-layer methods. Second, the efficiency of cloth/human collision detection is improved by introducing auxiliary line segments. Some heuristics are provided to further increase the efficiency of collision detection. Experimental results demonstrate that our method is efficient for clothed human animation.
Homofermentative Production of <scp>d</scp> - or <scp>l</scp> -Lactate in Metabolically Engineered <i>Escherichia coli</i> RR1 (1999)

We investigated metabolic engineering of fermentation pathways in Escherichia coli for production of optically pure D- or L-lactate. Several pta mutant strains were examined, and a pta mutant of E. coli RR1 which was deficient in the phosphotransacetylase of the Pta-AckA pathway was found to metabolize glucose to D-lactate and to produce a small amount of succinate by-product under anaerobic conditions. An additional mutation in ppc made the mutant produce D-lactate like a homofermentative lactic acid bacterium. When the pta ppc double mutant was grown to higher biomass concentrations under aerobic conditions before it shifted to the anaerobic phase of D-lactate production, more than 62.2 g of D-lactate per liter was produced in 60 h, and the volumetric productivity was 1.04 g/liter/h. To examine whether the blocked acetate flux could be reoriented to a nonindigenous L-lactate pathway, an L-lactate dehydrogenase gene from Lactobacillus casei was introduced into a pta ldhA strain which lacked phosphotransacetylase and D-lactate dehydrogenase. This recombinant strain was able to metabolize glucose to L-lactate as the major fermentation product, and up to 45 g of L-lactate per liter was produced in 67 h. These results demonstrate that the central fermentation metabolism of E. coli can be reoriented to the production of D-lactate, an indigenous fermentation product, or to the production of L-lactate, a nonindigenous fermentation product.
Isomeric pyridopyrazines from the reaction of some tetraaminopyridines with pyruvaldehyde and benzil (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsomeric pyridopyrazines from the reaction of some tetraaminopyridines with pyruvaldehyde and benzilRobert D. Elliott, Carroll Temple Jr., and John A. MontgomeryCite this: J. Org. Chem. 1968, 33, 6, 2393–2397Publication Date (Print):June 1, 1968Publication History Published online1 May 2002Published inissue 1 June 1968https://pubs.acs.org/doi/10.1021/jo01270a048https://doi.org/10.1021/jo01270a048research-articleACS PublicationsRequest reuse permissionsArticle Views116Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification and subcellular localization of sphinganine-phosphatases in rat liver (1995)

One of the primary products of [4,5-3H]sphinganine phosphate, added to fibroblast cultures, is sphinganine [Van Veldhoven and Mannaerts (1994) Biochem. J. 299, 597-601], implicating the physiological action of (a) hitherto unknown phosphatase(s). We have now further characterized this activity in rat liver. In homogenates, the dephosphorylation appeared to be catalysed by multiple enzymes. A low-affinity system was active at acidic pH, whereas at physiological pH values hydrolysis was carried out by a high-affinity enzyme. The latter was sensitive to Zn2+ and detergents and possessed a pH optimum of 7.5. Upon cell fractionation the major portion of the high-affinity activity was recovered in the nuclear and microsomal fractions. Further separation of the microsomal fraction showed an association predominantly with vesicles derived from the plasma membrane. Likewise, when plasma membranes were prepared from the nuclear fraction, the high-affinity phosphatase co-purified with the plasma membrane markers. From the differential effects of bivalent cations, chelators, water-soluble and amphiphilic phosphate esters, detergents and other compounds, it could be concluded that the plasma membrane-associated sphinganine-phosphatase activity is not due to alkaline phosphatase, dolichol-phosphatase, the N-ethylmaleimide-insensitive phosphatidate phosphatase or ceramide-phosphatase. The dephosphorylation observed at acidic pH in homogenates appeared also to be enriched in purified plasma membranes and might represent a side-activity of ceramide-phosphatase. We speculate that the high-affinity phosphatase, which is especially active in neuronal tissues, plays a role in the attenuation of bioactive phosphorylated sphingoid bases such as sphingenine phosphate, and propose to name it sphingosine-phosphatase.
Evaluation of a rapid point-of-care test for the detection of gonococcal infection among female sex workers in Benin (2006)

The PATH GC-Check test may be as efficient as a gold standard polymerase chain reaction (PCR) test for treating gonococcal infection when taking into account the proportion of women who do not return for their test results. In clinics serving populations with moderate prevalence of this infection, it could significantly reduce over-treatment compared to the syndromic approach.