gebhart/patrepeval huggingface dataset:
Development of a Fast Response Molecular Recognition Ion Gating Membrane (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDevelopment of a Fast Response Molecular Recognition Ion Gating MembraneTakeo Yamaguchi, Taichi Ito, Taketoshi Sato, Toshio Shinbo, and Shin-ichi NakaoView Author Information Department of Chemical System Engineering The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656, Japan Cite this: J. Am. Chem. Soc. 1999, 121, 16, 4078–4079Publication Date (Web):April 8, 1999Publication History Received4 December 1998Published online8 April 1999Published inissue 1 April 1999https://pubs.acs.org/doi/10.1021/ja984170bhttps://doi.org/10.1021/ja984170brapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1230Altmetric-Citations127LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ethers,Ions,Membranes,Polymers,Solution chemistry Get e-Alerts
Sentence Similarity Measures for Fine-Grained Estimation of Topical Relevance in Learner Essays (2016)

We investigate the task of assessing sentencelevel prompt relevance in learner essays. Various systems using word overlap, neural embeddings and neural compositional models are evaluated on two datasets of learner writing. We propose a new method for sentencelevel similarity calculation, which learns to adjust the weights of pre-trained word embeddings for a specific task, achieving substantially higher accuracy compared to other relevant baselines.
Research and Design of Website User Behavior Data Acquisition Based on Customized Event Tracking (2019)

Nowadays, it is particularly important to obtain user behavior data accurately, as the big data technology is developing at a high speed and the users of various types of websites is also increasing. The current mainstream practice is that users can design their own user behavior statistical analysis function modules or use other third-party platforms, which can analyze only the general user behavior of network services, such as Baidu Statistics and Zhuge Platform. However, each specific social network has its own user behaviors, to analyze them often requiring a self-designed special software [14], which is very difficult to develop. The embedded script provided by the third party can not be customized according to the needs of its users. In this paper, a new embedded design scheme of self-defined web pages based on general label binding, special attribute specific embedded point, form label binding and back-end reverse scanning monitoring technology is proposed, and it is verified that data acquisition and intelligent analysis of user behavior can be better completed on any website.
Offloading Cryptographic Services to the SIM Card (2018)

Mobile OS security relies heavily on cryptography. Features like file or device encryption and secure keystores are essential to protect user data from intrusions. As smartphones increasingly gain popularity, mobile platforms keep evolving their hardware and software modules that work as cryptographic providers for the rest of the system. These solutions are usually designed to resist software attacks by introducing a Trusted Execution Environment (TEE). This kind of protection is not enough when physical control over the device is lost. Secure elements such as smart cards, on the other hand, include a set of protections that make them physically tamper resistant devices. In this paper we propose the use of the SIM card, the only universally present secure element in mobile phones, as a cryptographic provider and put forward a proof-of-concept prototype developed under Android OS. We also present the results of a performance evaluation that was conducted and study the impact on battery consumption, comparing our solution to the default implementation of an Android mobile phone. Despite some performance limitations our approach proves to be a valid alternative to provide enhanced security features on any smartphone.
Synthesis of Alkaloids, Cleistopholine, Oxylopine (Isoursuline), and Ursuline (1989)

synthesis of alkaloids, cleistopholine, oxylopine (isoursuline), ursuline, and related compounds by application of a method for constructing cycloalkenopyridines was described and the synthesis revealed that the structure of oxylopine should be revised to 6-hydroxy-5-methoxyonychine from 5-hydroxy-6-methoxyonychine.Previously, we reported1) the synthesis of the compound, l-methyl-4-azafluoren-9-one (l), corresponding to the structure of onychine (the revised structure by us1) and A. cav6's group2) ) occurring in Onychopetalum amazonicum (Annonaceae), by application
A Developmentally Regulated Heparan Sulfate Epitope Defines a Subpopulation with Increased Blood Potential During Mesodermal Differentiation (2008)

Heparan sulfate (HS) is a mandatory coreceptor for many growth factors and morphogens involved in embryonic development; its bioactivity is dictated by complex sulfation motifs embedded within the polymer chain. Using a panel of HS-specific antibodies we have identified a unique HS epitope recognized by antibody HS4C3 that is selectively expressed during differentiation of embryonic stem (ES) cells along the mesodermal lineage to the hemangioblast stage. The appearance of this high-affinity HS4C3-binding (HS4C3(high)) epitope is transient; the epitope is specifically expressed within the emerging Brachyury(+) (Bry(+)) population and marks those cells that will become fetal liver kinase 1 (Flk1)(+). Fluorescence-activated cell sorting (FACS) separation and colony forming assays revealed that HS4C3(high)/Flk1(+) cells have a dramatically increased potential to form both blast and endothelial colonies, both of which depend upon the HS-binding growth factor vascular endothelial growth factor. Critically, expression of this HS epitope is tightly regulated, disappearing from the cell surface as the resultant hematopoietic lineages mature, in a similar manner to protein markers Bry and Flk1. In vivo studies showed a remarkable correlation with in vitro findings, with expression of HS4C3-binding epitopes restricted to newly formed mesodermal tissues during gastrulation. We believe this is the first time a defined HS epitope has been implicated in a specific developmental pathway and that this provides, in addition, a novel enrichment technique for the isolation of hemangioblasts from mixed differentiated ES cell cultures.
Recent Advances in the Discovery of &#945;1-Adrenoceptor Agonists (2006)

The alpha(1) adrenoceptors are three of nine well-characterized receptors that are activated by epinephrine and norepinephrine. Agonists acting at the alpha(1) adrenoceptors produce numerous physiological effects, and are used therapeutically for several indications. Many known alpha(1) adrenoceptor agonists are alpha(1A) selective, but the discovery of highly selective alpha(1B) and alpha(1D) adrenoceptor agonists has proven to be an extremely difficult goal to achieve. This review will focus on recent advances in the discovery, development and clinical utility of subtype-specific alpha(1) agonists as well as contributions to our understanding of agonist-receptor interactions.
Computer Assisted Instruction with Learning Disabled Students: Achievement, Engagement, and other Factors That Influence Achievement (1990)

The study compared computer assisted instruction (CAI) and paper-and-pencil instruction (PPI) as means of delivering independent spelling practice in classes for learning disabled (LD) students. Forty-four fifth- and sixth-grade LD students worked for four weeks on CAI or PPI spelling programs. The CAI and PPI programs had identical content and similar activities, but differed in instructional design features based on the capabilities of the two media. Important contextual factors were controlled, including the teacher, the teacher's role, time of day, amount of practice time, and proximity to peers and teachers in the classroom. Significant achievement differences favoring the CAI group were found on the weekly spelling tests and on a retention test. In addition, the CAI group had a significantly higher engagement rate, and engagement was positively correlated with average weekly achievement. Recursive path analysis was used to explore further the hypothesis that improved achievement with CAI is mediated by engagement. The path analysis indicated that approximately 31 percent of the difference in achievement between groups was mediated by engagement and another 22 percent by engagement through number of responses.
Real-Time Imaging and Quantification of Amyloid-β Peptide Aggregates by Novel Quantum-Dot Nanoprobes (2009)

These data demonstrate that QDAbeta is a novel nanoprobe for studying Abeta oligomerization and fibrillization in multiple modalities and may be applicable for high-throughput drug screening systems.
A scalable system for automating outage management for electrical utilities (2002)

This paper discusses the challenges and critical success factors of scaling low-cost solutions for utility trouble call entry and management that were generally used at coops and municipal utilities to meet the needs of larger utilities through actual implementation experiences.
Potential distributions and excitation time maps recorded with high spatial resolution from the entire ventricular surface of exposed dog hearts (2003)

The authors recorded potential maps, excitation and recovery time maps from the entire ventricular surface of exposed dog hearts using an epicardial sock with 630 electrodes spaced 4 mm, during atrial pacing or ventricular pacing at various intramural depths. Results made it possible to describe complex distributions of excitation and recovery isochrones. Ventricular pacing produced five epicardial areas characterized by different densities of isochrone lines, during both excitation and recovery. Potential maps revealed times and locations of up to 17 epicardial breakthroughs and enabled localization of a number of electrical events that were difficult to detect with previously used electrode arrays.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An efficient medium access control protocol for high-speed networks (2002)

In this paper, we propose a new medium access control (MAC) layer protocol, called optical reservation multiple access (ORMA), which is suitable for data traffic on a folded bus high-speed MANs and LANs. Its main feature is an optical reservation technique, to allow stations to reserve transmission slots, which is attractive for use in high-speed networks. Unlike traditional protocols where reservation is mostly done using software, ORMA performs its reservation function using simple and efficient optical hardware circuits. A complete description of the ORMA protocol is given. Then, ORMA is shown to achieve high throughput and small transmission delays while preserving the fairness of the whole network.
Commentary: New advances in the development of therapies for treating inherited skin fragility disorders (2015)

Inherited skin fragility disorders comprise a group of disorders, mainly designated as epidermolysis bullosa (EB), that are characterised by mechanical induced blistering and erosions of the skin and mucous membranes caused by mutations of gene coding for protein components of the dermal-epidermal junction zone. Patients with EB experience various degrees of recurrent skin blistering, widespread bullae, and erosions that characteristically heal with exuberant scarring and milia formation or lead to impaired non-healing wounds and the development of aggressive skin cancers. Advances in understanding the pathogenesis of EB in the last decade have led to the identification of several candidate genes and proteins and the development of several therapeutic strategies currently progressing to pre-clinical and clinical stages. This review will focus on the recent advances in the development of these new therapies for treating inherited skin fragility disorders (with particular focus on recessive dystrophic epidermolysis bullosa), which hold great promise for improving the quality of life for patients suffering from EB.
Disturbances of Wnt/ -catenin pathway and energy metabolism in early CKD: effect of phosphate binders (2013)

Early stages of CKD are associated with an impairment of the Wnt pathway, as reflected by elevated sclerostin, and a dysregulation of energy-regulating hormones. Many of these disturbances can be ameliorated by phosphate binder treatment, more with sevelamer-HCl than with calcium acetate.
ChemInform Abstract: 4‐AMINO‐5‐ARYLPYRIMIDINES AS ANTIINFLAMMATORY AGENTS (1975)

Abstract Zur Untersuchung auf entzündungshemmende Wirkung werden zahlreiche 5‐Aryl‐4‐ aminopyrimidine (I) in Tabellen aufgeführt.
SAMHD1 protects cancer cells from various nucleoside-based antimetabolites (2017)

Recently, we demonstrated that sterile α motif and HD domain containing protein 1 (SAMHD1) is a major barrier in acute myelogenous leukemia (AML) cells to the cytotoxicity of cytarabine (ara-C), the most important drug in AML treatment. Ara-C is intracellularly converted by the canonical dNTP synthesis pathway to ara-CTP, which serves as a substrate but not an allosteric activator of SAMHD1. Using an AML mouse model, we show here that wild type but not catalytically inactive SAMHD1 reduces ara-C treatment efficacy in vivo. Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine. Within this Extra View, we discuss and build upon both these and our previously reported findings, and propose SAMHD1 is likely active against a variety of nucleoside analog antimetabolites present in anti-cancer chemotherapies. Thus, SAMHD1 may constitute a promising target to improve a wide range of therapies for both hematological and non-haematological malignancies.
Superoxide dismutase from Bacillus stearothermophilus. Complete amino acid sequence of a manganese enzyme (1980)

Superoxide dismutase from the thermophilic bacterium Bacillus stearothermophilus is dimeric with a molecular weight of 45 487. It contains one atom manganese(III) per dimeric molecule [Brock, C. J., Harris, J. I., & Sato, S. (1976) J. Mol. Biol. 107, 175-178]. The subunits are identical, and the following primary structure comprising 203 amino acids has been determined: (Formula: see text) The enzyme is identical in 60% of its residues with the Escherichia coli B manganese enzyme [Steinman, H. M. (1978) J. Biol. Chem 253, 8708-8720]. Neither manganese enzyme has significant homology with the Cu/Zn superoxide dismutase from bovine erythrocytes. The secondary structures of the manganese enzymes predicted by McLachlan's method [McLachlan, A. D. (1977) Int.J. Quantum chem. 12, 371-385] indicate that the eight-stranded beta barrel of the Cu/Zn enzyme [Richardson, J.S., Thomas, K. A., Byron, H. R., & Richardson, D. C. (1975) Proc. Natl. Acad. Sci. U.S.A. 72, 1349-1353] is absent from the manganese enzymes.
Mimosine, the Allelochemical from the Leguminous Tree <i>Leucaena leucocephala</i> , Selectively Enhances Cell Proliferation in Dinoflagellates (2002)

Mimosine, the allelochemical from the leguminous tree Leucaena leucocephala, is toxic to most terrestrial animals and plants. We report here that while mimosine inhibits major phytoplankton groups, it enhances cell proliferation in dinoflagellates. On addition to coastal seawater samples, mimosine is able to confer a growth advantage to dinoflagellates. The use of mimosine will promote the isolation and culture of this group of phytoplankton.
INDIVIDUAL AND COMBINED LISTERICIDAL EFFECTS OF SODIUM LACTATE, POTASSIUM SORBATE, NISIN AND CURING SALTS AT REFRIGERATION TEMPERATURE (1995)

ABSTRACT The individual and combined antilisterial activity of the preservatives sodium lactate (4%), potassium sorbate (0.3%) and nisin (400 IU/ml), in either the presence or absence of the curing salts nitrite (125 ppm) and polyphosphate (0.5%), was assessed in buffered BHI broth (pH 5.5) during incubation at 4C. A cocktail of the strain Listeria monocytogenes NCTC 7973 and two food derived strains was used as the inoculum in challenge studies. In the absence of the preservatives , L. monocytogenes grew in the presence of polyphosphate but not in the presence of nitrite or a combination of nitrite and polyphosphate. The antilisterial action of nitrite was predominantly bacteriostatic in nature. Lactate acting alone, or in the presence of curing salts, produced a bacteriostatic effect. Sorbate acting alone had a bacteriostatic effect. Sorbate acting in the presence of nitrite or nitrite and polyphosphate produced a marked listericidal effect, reducing the population by 6.7 logs and 5.4 logs, respectively. Nisin acting alone produced an almost immediate 90% listericidal response (1 log population decrease), but initial numbers were restored within 14 days by regrowth. Regrowth was eliminated when nisin was used in combination with lactate, nitrite or nitrite and polyphosphate. The combination of lactate and sorbate offered no advantage over the use of sorbate alone. Sorbate and nisin acting in combination produced an enhanced listericidal effect, which was also seen in the presence of curing salts, but was delayed. No listericidal advantage over sorbate‐nisin combination was achieved through the use of the lactate‐sorbate‐nisin combination. The combined use of sorbate and nisin offers promise as a means of eliminating L. monocytogenes from low pH cured meat products. The efficacy of this preservative combination remains to be evaluated in a meat system before its practical application can be considered .
Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of <i>Quillaja</i> saponin vaccine adjuvants (2015)

Correction for 'Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants' by Alberto Fernández-Tejada et al., Chem. Commun., 2015, DOI: 10.1039/c5cc05244k.
Physiological regulation of the picrotoxin receptor by gamma- butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons (1990)

We examined the effects of alkyl-substituted gamma-butyrolactones (GBLs), and gamma-thiobutyrolactones (TBLs) on GABA currents in cultured, voltage-clamped rat hippocampal neurons. Convulsant GBLs and TBLs reversiby diminished GABA responses in a concentration-dependent manner. beta-Ethyl-beta-methyl GBL (beta-EMGBL) completely abolished GABA responses at 3 mM (IC(50)390 microM), while TBL and beta-ethyl-beta-methyl TBL (beta-EMTBL)-induced inhibition of GABA currents was incomplete, saturating at about 50% of control at 300 microM and 10 mM for beta-EMTBL and TBL, respectively. beta-EMGBL and beta-EMTBL both increased the rate of decay of inhibitory post-synaptic currents (IPSCs) and beta-EMGBL also decreased IPSC peak amplitude. In contrast, the anticonvulsant alpha-ethyl-alpha-methyl TBL (alpha-EMTBL) potentiated GABA currents at all GABA concentrations tested; maximal potentiation was 190% of control at 1 mM alpha-EMTBL (EC50 102 microM). Another anticonvulsant alpha-ethyl-alpha-methyl GBL (alpha-EMGBL), potentiated responses to low (0.5 microM) but not high (greater than or equal to 10 microM) GABA. It also blocked the inhibitory effects of picrotoxin and beta-EMGBL and the facilitative effect of alpha-EMTBL on responses to 30 microM GABA. alpha-EMGBL did not interfere with other agents which augment GABA currents. Both alpha-EMTBL and alpha-EMGBL decreased the rate of IPSC decay without altering IPSC peak amplitude. None of these compounds had any direct membrane effects. We propose that beta-alkyl GBLs diminish GABA currents, and therefore, we hypothesize that these compounds are picrotoxin receptor agonists. beta-Alkyl TBLs partially diminish GABA currents and may be partial agonists.(ABSTRACT TRUNCATED AT 250 WORDS)
Three-dimensional vision using structured illumination (1985)

Structured light vision systems offer a practical solution to many 3-D inspection problems. We examine the trade-offs involved in the design of 3-D inspection systems that use triangulation and show how a triangulation-based system can be designed to fit a given application. A general analysis of such systems is performed resulting in a description of the design constraints, which include such aspects of the system as resolution matching and aliasing prevention. The selection of light sources and detectors is addressed in light of the nonideal aspects of their behavior and various schemes are presented for compensating for these effects. The relative advantages and disadvantages of point, stripe, and multistripe systems are explained and the implementation of a multistripe system is discussed. Problems common among structured light systems, such as speckle and varying object reflectivity, are explored and alternative solutions are presented. Several data interpretation techniques are evaluated and compared, and their actual and theoretical performances are contrasted. Experimental results from a prototype system are presented.
Analysis of power system transients using wavelets and Prony method (2002)

Transients resulting from switching of capacitor banks in electrical distribution systems affects power quality. The transient overvoltages can theoretically reach peak phase to earth values in the order of 2.0 p.u. High current transients can reach values to ten times the capacitor nominal current with duration of several milliseconds. Another severe operating condition is the switching on a second capacitor bank connected to the same bus. In the work, the characteristics of the transients are analyzed. The time of the beginning of a transient process is detected using a wavelet transform. The frequencies of transient components have been investigated applying the Fourier technique and the Prony model. The investigations show the advantages of the methods basing on the Prony model, over the Fourier technique. A distribution system was simulated using the EMTP software.
Biotechnology of Forest Yield (1983)

Silvicultural and genetic manipulation of Douglas fir and loblolly pine plantations have increased their productivity 70 and 300 percent, respectively, over natural forests on the same sites. Yet these intensively managed plantations are achieving less than 50 percent of their potential productivity. Future increases in yield will result from optimization of nutritional treatments, control of noncrop vegetation, and advances in tree breeding and tissue culture techniques.