gebhart/patrepeval huggingface dataset:
A Program for Congregation-Based Short-Term International Evangelistic Campaigns (2003)

The Problem. The purpose of this research was to develop and evaluate a program to facilitate short-term mission trips originating in North American Division congregations and conducted in cooperation with local members in international settings, especially outside North America. The Method. A short-term mission trip conducted in 1999 by the Florence and Reedsport, Oregon, Seventh-day Adventist churches and an ongoing short-term mission program being conducted by members of the Medford, Oregon, church, all to locations in India, were selected for evaluation. Selection was based on similarity to the program developed for the research and convenience of access to the congregations by the researcher. A subjective questionnaire designed by the researcher and personal interviews were used in soliciting feedback from North American participants. Telephone interviews were used in soliciting feedback from church workers in India affected by the respective campaigns. Feedback from both groups was compared and contrasted for a subjective evaluation of the effectiveness of the program. The Results. The components of the proposed program were affirmed by the responses of the Indian interviewees and the comparison of their responses with those of the North American participants. Conclusions. The research affirmed the value of training for prospective short-term missionaries, including opportunity for examination of cultural preconceptions. Subjects’ responses seemed to support the recommendation of the program that members be assigned duties on the basis of their demonstrated spiritual gifts. The need for North American groups preparing for mission travel to make concerted efforts at clear communication and coordination with believers in the target area is supported by the research. The propriety of considering the ambient culture in determining the technology to be used in evangelism is affirmed by the program evaluation. The inclusion of funding for local evangelistic workers and church buildings in the campaign budget is supported by the research. The research supports the concept and practice of holistic mission when applied in harmony with other mission principles.
CerealsDB 2.0: an integrated resource for plant breeders and scientists (2012)

CerealsDB is an open access website that is rapidly becoming an invaluable resource within the wheat research and plant breeding communities.
Decoherence mechanisms of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msup><mml:mrow/><mml:mn>209</mml:mn></mml:msup></mml:math>Bi donor electron spins in isotopically pure<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msup><mml:mrow/><mml:mn>28</mml:mn></mml:msup></mml:math>Si (2012)

Bismuth (${}^{209}$Bi) is the deepest group V donor in silicon and possesses the most extreme characteristics such as a 9/2 nuclear spin and a 1.5 GHz hyperfine coupling. These lead to several potential advantages for a Si:Bi donor electron spin qubit compared to the more common phosphorus donor. Most previous studies on Si:Bi have been performed using natural silicon where linewidths and electron spin coherence times are limited by the presence of ${}^{29}$Si impurities. Here, we describe electron spin resonance (ESR) and electron nuclear double resonance (ENDOR) studies on ${}^{209}$Bi in isotopically pure ${}^{28}$Si. ESR and ENDOR linewidths, transition probabilities, and coherence times are understood in terms of the spin Hamiltonian parameters showing a dependence on field and ${m}_{I}$ of the ${}^{209}$Bi nuclear spin. We explore various decoherence mechanisms applicable to the donor electron spin, measuring coherence times up to 700 ms at 1.7 K at X band, comparable with ${}^{28}$Si:P. Importantly, the coherence times we measure follow closely to the calculated field gradients of the transition frequencies ($df/dB$), providing a strong motivation to explore ``clock'' transitions where coherence lifetimes could be further enhanced.
Rearrangement of .alpha.-ethynyl alcohols to unsaturated carbonyl compounds (The Rupe Reaction) (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRearrangement of .alpha.-ethynyl alcohols to unsaturated carbonyl compounds (The Rupe Reaction)Richard W. Hasbrouck and Ann D. AndersonCite this: J. Org. Chem. 1973, 38, 11, 2103–2106Publication Date (Print):June 1, 1973Publication History Published online1 May 2002Published inissue 1 June 1973https://pubs.acs.org/doi/10.1021/jo00951a037https://doi.org/10.1021/jo00951a037research-articleACS PublicationsRequest reuse permissionsArticle Views309Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Anti-Inflammatory and Antiproliferative Activities of Trifolirhizin, a Flavonoid from<i>Sophora flavescens</i>Roots (2009)

Trifolirhizin, a pterocarpan flavonoid, was isolated from the roots of Sophora flavescens, and its chemical structure was confirmed by (1)H and (13)C NMR and MS spectra. Its anti-inflammatory activity was examined in lipopolysaccharide (LPS)-stimulated mouse J774A.1 macrophages. Trifolirhizin not only dose-dependently inhibited LPS-induced expression of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) but also inhibited lipopolysaccharide (LPS)-induced expression of cyclooxygenase-2 (COX-2). In addition, trifolirhizin showed in vitro inhibitory effects on the growth of human A2780 ovarian and H23 lung cancer cells. These results suggest that trifolirhizin possesses potential anti-inflammatory and anticancer activities.
Itraconazole or allopurinol in the treatment of chronic American trypanosomiasis: the results of clinical and parasitological examinations 11 years post-treatment (2005)

Eleven years after they had been given itraconazole or allopurinol for the treatment of chronic American trypanosomiasis, 109 adult patients were checked for electrocardiographic abnormalities and evidence of Trypanosoma cruzi infection. The parasitological investigations included xenodiagnosis, in which the faeces of Triatoma infestans that had fed on the patients were checked under the microscope for flagellates. In addition, a PCR-based assay and a hybridization assay were used to test blood samples from the patients, and faeces from the Tri. infestans that had fed on the patients, for Try. cruzi DNA. For the data analysis, the patients were divided into four groups known as normal/normal, abnormal/normal, normal/abnormal and abnormal/abnormal, according to whether the patients had been found to have normal or abnormal electrocardiograms (ECG) shortly before the first treatment and to have normal or abnormal ECG when checked at the 11-year follow-up. The 51 normal/normal and 24 normal/abnormal patients were assumed to have been in the 'indeterminate' phase of the disease when they were treated, whereas the 16 abnormal/normal and 18 abnormal/abnormal patients all had evidence of chagasic cardiopathy at that time. When checked 11 years post-treatment, 40 (78.4%), 17 (70.8%), 14 (87.5%) and 17 (94.4%) of these patients, respectively, were each found positive for Try. cruzi in at least one of the parasitological tests. The hybridization assay, whether applied to human blood or bug faeces, appeared a significantly more sensitive test than the PCR-based assays or microscopically assessed xenodiagnosis (P<0.05). Only the 21 patients who appeared to be negative for Try. cruzi could be considered parasitologically cured (although all still appeared to have anti-Try. cruzi antibodies in their blood). Only 13 of these parasitologically cured patients (seven of those treated with itraconazole and six of those given allopurinol) had normal ECG at the 11-year follow-up. In Chile at least, itraconazole, which caused fewer adverse effects than the allopurinol while being no less effective at preventing cardiopathy, appears to be the drug of choice to treat chronic American trypanosomiasis in adults.
Axon Guidance by Gradients of a Target-Derived Component (1992)

Spatial gradients of axon guiding molecules have long been suspected to provide positional and directional cues for retinal ganglion cell axons growing within the optic tectum. With the identification of a guiding activity from tectal cell membranes, it has become possible to investigate the potential physiological significance of molecular gradients for retinal growth cone behavior in vitro. A subset of retinal growth cones, those from the temporal half, were highly sensitive to small concentration changes of the guiding component. The degree of response was correlated with the strength of the gradient. These findings demonstrate that the neural growth cone can read gradients of surface-associated information.
Morphine in Postoperative Patients: Pharmacokinetics and Pharmacodynamics of Metabolites (2007)

M-6-G is a potent opioid agonist and M-3-G a mild opioid antagonist. Both are poorly excreted in patients with renal failure. However, the metabolism of morphine was rapid when compared to the transfer of metabolites through the blood-brain barrier, which appears to be the limiting process. Because poor analgesia due to M-3-G's effect may occur in some patients after 1 or 2 days, a switch to other molecules should be considered.
Preparation and High T<sub>c</sub> Superconductivity of Ba-Y-Cu Oxides (1987)

High T c superconductors of monophase, Ba 2 YCu 3 O 8- x , and mixed phase samples were prepared from mixtures with Ba/Y/Cu ratios of 2/1/3 and 2/1/3.5, respectively. They were investigated by dc electrical measurements and X-ray diffraction. All samples have basically an orthogonal structure. The zero-resistivity temperatures for the monophase and mixed phase samples were 86 K and 77 K, respectively. The reason for the different superconducting characteristics is also discussed.
Multimodal Graph-Based Reranking for Web Image Search (2012)

This paper introduces a web image search reranking approach that explores multiple modalities in a graph-based learning scheme. Different from the conventional methods that usually adopt a single modality or integrate multiple modalities into a long feature vector, our approach can effectively integrate the learning of relevance scores, weights of modalities, and the distance metric and its scaling for each modality into a unified scheme. In this way, the effects of different modalities can be adaptively modulated and better reranking performance can be achieved. We conduct experiments on a large dataset that contains more than 1000 queries and 1 million images to evaluate our approach. Experimental results demonstrate that the proposed reranking approach is more robust than using each individual modality, and it also performs better than many existing methods.
Differential Mobilization of CD34 <sup>+</sup> Cells and Lymphoma Cells in Non-Hodgkin's Lymphoma Patients Mobilized with Different Growth Factors (2001)

Co-mobilization of CD34(+) cells and tumor has been documented in patients with different types of cancer undergoing peripheral blood stem cell transplantation (PBSCT). Conflicting reports were published regarding the role of various growth factors in tumor cells mobilization, hence we studied the extent of CD34(+) cells and lymphoma cell mobilization in 35 non-Hodgkin's (NHL) patients primed by cyclophosphamide (Cy) in combination with granulocyte colony-stimulating factor (GCSF) (A, 13 patients), granulocyte-macrophage (GM)-CSF (B, 10 patients), or GM-CSF followed by G-CSF (C, 12 patients). CD34(+) cells were quantitated by flow cytometry and lymphoma cells by the TaqMan Real Time PCR for bcl-2 gene rearrangement. Successful collection in 4 days of > or = 2 x 10(6) CD34(+) cells/kg needed for prompt engraftment was obtained in 76%, 60%, and 58% of patients in arms A, B, and C, respectively. Lymphoma cell mobilization was detected in 35% patients tested, 78% of which had follicular lymphoma. Lymphoma cell mobilization was similar in the three arms of the study, however, presence of lymphoma cells was prevalent in patients who failed to mobilize the amount of 0.4 x 10(6) CD34(+) cells/kg in 2 days ("poor mobilizers") and reached 42%, compared to 17% in the "successful mobilizers" group of patients. Lymphoma cell contamination in PBSCs was detected proportionately in the peripheral blood and in the bone marrow. We conclude that bcl-2 gene rearrangement is prevalent in patients with follicular histology, and, in these patients, an inverse relationship was observed between mobilization of CD34(+) cells and lymphoma cells. Our results explain the high relative risk (1.98) for mobilization in patients with follicular histology.
Sox10 Controls Migration of B16F10 Melanoma Cells through Multiple Regulatory Target Genes (2012)

It is believed that the inherent differentiation program of melanocytes during embryogenesis predisposes melanoma cells to high frequency of metastasis. Sox10, a transcription factor expressed in neural crest stem cells and a subset of progeny lineages, plays a key role in the development of melanocytes. We show that B16F10 melanoma cells transfected with siRNAs specific for Sox10 display reduced migratory activity which in turn indicated that a subset of transcriptional regulatory target genes of Sox10 is likely to be involved in migration and metastasis of melanoma cells. We carried out a microarray-based gene expression profiling using a Sox10-specific siRNA to identify relevant regulatory targets and found that multiple genes including melanocortin-1 receptor (Mc1r) partake in the regulation of migration. We provide evidences that the effect of Sox10 on migration is mediated in large part by Mitf, a transcription factor downstream to Sox10. Among the mouse melanoma cell lines examined, however, only B16F10 showed robust down-regulation of Sox10 and inhibition of cell migration indicating that further dissection of dosage effects and/or cell line-specific regulatory networks is necessary. The involvement of Mc1r in migration was studied in detail in vivo using a murine metastasis model. Specifically, B16F10 melanoma cells treated with a specific siRNA showed reduced tendency in metastasizing to and colonizing the lung after being injected in the tail vein. These data reveal a cadre of novel regulators and mediators involved in migration and metastasis of melanoma cells that represents potential targets of therapeutic intervention.
Strength Testing—Predicting a One-Rep Max from Reps-to-Fatigue (1993)

(1993). Strength Testing—Predicting a One-Rep Max from Reps-to-Fatigue. Journal of Physical Education, Recreation & Dance: Vol. 64, No. 1, pp. 88-90.
A New Spatial Three-DoF Parallel Manipulator With High Rotational Capability (2005)

This paper concerns the proposal and analysis of a novel spatial parallel manipulator. The parallel manipulator consists of a base plate, a movable platform, and three connecting legs. The moving platform has three degrees of freedom (DoFs), which are two degrees of translational freedom and one degree of rotational freedom, with respect to the base plate. The inverse and forward kinematics problems are described in closed forms and the velocity equation of the new parallel manipulator is given. Three kinds of singularities are presented. The workspace for the manipulator is analyzed systematically. Especially, the indices to evaluate the rotational capability of the moving platform of the manipulator will be defined and discussed in detail. Due to the high rotational capability performance, the proposed manipulator has wide application in the fields of industrial robots, simulators, micromotion manipulators, and parallel kinematic machines.
New inference strategies for solving Markov decision processes using reversible jump MCMC (2009)

In this paper we build on previous work which uses inferences techniques, in particular Markov Chain Monte Carlo (MCMC) methods, to solve parameterized control problems. We propose a number of modifications in order to make this approach more practical in general, higher-dimensional spaces. We first introduce a new target distribution which is able to incorporate more reward information from sampled trajectories. We also show how to break strong correlations between the policy parameters and sampled trajectories in order to sample more freely. Finally, we show how to incorporate these techniques in a principled manner to obtain estimates of the optimal policy. 1
Harmonic control using an active drive (2003)

A method is presented by which the harmonic current in a two-level, network-connected inverter can be controlled for use as an active filter in addition to supplying real power, via the intermediate DC link to a motor inverter. With the use of variable speed drives incorporating sinusoidal rectifiers there exists the possibility that the PWM-modulated voltage of the sinusoidal front end, or network rectifier, could be modulated to inject harmonic current into the network. This would allow compensation of harmonic voltage distortion caused by other nonlinear loads already connected to the busbar. The use of a commercially available variable speed drive with sinusoidal rectifier is described which, from the distorted busbar voltage, derives the correct current references with which to compensate for 5th- and 7th-harmonic voltage distortion. The method by which the harmonic current references are determined and the method by which they are controlled is presented in detail. The concept of using mains voltage distortion at the point of common coupling as feedback is justified.
Induction of passive immunity in broiler chickens against Eimeria acervulina by hyperimmune egg yolk immunoglobulin Y (2009)

The protective effect of hyperimmune IgY fraction of egg yolk prepared from hens hyperimmunized with multiple species of Eimeria oocysts on experimental coccidiosis was evaluated in young broilers. Chickens were continuously fed from hatch with a standard diet containing hyperimmune IgY egg yolk powder or a nonsupplemented control diet and orally challenged at d 7 posthatch with 5.0 x 10(3) sporulated Eimeria acervulina oocysts. Body weight gain between d 0 and 10 and fecal oocyst shedding between d 5 and 10 postinfection were determined as parameters of protective immunity. Chickens given 10 or 20% hyperimmune IgY egg yolk powder showed significantly increased BW gain and reduced fecal oocyst shedding compared with control birds fed the nonsupplemented diet. In another trial, lower IgY concentrations (0.01, 0.02, and 0.05%) were used to treat birds with 1.0 x 10(4) oocysts of E. acervulina. Total oocyst shedding was significantly (P < 0.05) reduced in chickens fed the 0.02 and 0.05% hyperimmune IgY supplemented-diets compared with animals fed the nonsupplemented diet. Similarly, chickens fed 0.5% of hyperimmune IgY egg yolk powder diet and challenged with 1.0 x 10(4) oocysts exhibited reduced oocyst shedding compared with the control birds given 0.5% of IgY from nonimmunized hen eggs, although BW gain was not affected. We conclude that passive immunization of chickens with anti-coccidia IgY antibodies provide protective immunity against coccidiosis challenge infection.
Buspirone: A New Type of Anxiolytic (1985)

Buspirone is a member of a new class of agents known as azaspirodecanediones, and represents the first nonbenzodiazepine anxiolytic to be introduced in the U.S. in recent years. It does not resemble the benzodiazepines or older anxiolytics such as meprobamate and the barbiturates in pharmacologic profile. Buspirone lacks anticonvulsant activity, interacts minimally with central nervous system depressants such as alcohol, and does not cause muscle relaxation. The drug is reported to have minimal sedating effect, to cause no impairment of driving-related skills, and to have no euphoriant effect or addictive potential. With this low side-effect profile, buspirone should not require Drug Enforcement Agency scheduling controls. Clinical trials indicate buspirone is efficacious in the treatment of mild to moderate anxiety disorders. Answers to questions of possible side effects related to dopaminergic intractions must await post-marketing experience. Buspirone is a suitable addition to drug formularies as its pre-marketing data suggest several advantages compared with anxiolytics currently available.
Novel insights into <scp>L</scp>‐2‐hydroxyglutaric aciduria: Mass isotopomer studies reveal 2‐oxoglutaric acid as the metabolic precursor of <scp>L</scp>‐2‐hydroxyglutaric acid (2007)

Employing lymphoblasts derived from two non related patients with L-2-HG aciduria, we examined the origin of L-2-hydroxyglutaric acid (L-2-HG) through incubation with [(13)C6]glucose and [(2)H5]glutamic acid. Formation of labelled 2-ketoglutaric acid (2-KG), citric acid and L-2-HG was determined by GC-MS. The quantitative and qualitative isotopomer pattern following incubation with [(13)C6]glucose was identical for all end-products. Incubations with [(2)H5]glutamic acid as precursor revealed the formation of identical isotopomers for 2-KG and L-2-HG. Our data indicate that 2-KG is the metabolic precursor of L-2-HG, adding to previous studies which revealed that 2-KG is the metabolic precursor of D-2-HG. These data suggest that 2-KG has a pathophysiological role in combined D/L-2-HG aciduria.
The Basics of<i>S-PLUS</i>, Fourth Edition (2005)

Abstracts not available for BookReviews
The Effect of the Potential PhoQ Histidine Kinase Inhibitors on Shigella flexneri Virulence (2011)

PhoQ/PhoP is an important two-component system that regulates Shigella virulence. We explored whether the PhoQ/PhoP system is a promising target for new antibiotics against S. flexneri infection. By using a high-throughput screen and enzymatic activity coupled assay, four compounds were found as potential PhoQ inhibitors. These compounds not only inhibited the activity of SF-PhoQc autophosphorylation but also displayed high binding affinities to the SF-PhoQc protein in the Surface Plasmon Resonance response. A S. flexneri cell invasion assay showed that three of these potential PhoQ inhibitors inhibit the invasion of HeLa cells by S. flexneri 9380. In a Mouse Sereny test, mice inoculated with S. flexneri 9380 pre-treated with the potential PhoQ inhibitors 1, 2, 3 or 4 displayed no inflammation, whereas mice inoculated with S. flexneri 9380 alone displayed severe keratoconjunctival inflammation. All four potential PhoQ inhibitors showed no significant cytotoxicity or hemolytic activity. These data suggest that the four potential PhoQ inhibitors inhibited the virulence of S. flexneri and that PhoQ/PhoP is a promising target for the development of drugs against S. flexneri infection.
Dose Reduction in Helical CT: Dynamically Adjustable <i>z</i>-Axis X-Ray Beam Collimation (2009)

Use of dynamic z-axis collimation reduces dose in helical CT by minimizing overscanning. Percentage dose reductions are larger for shorter scan lengths and greater pitch values.
PEGylated silicon nanoparticles: synthesis and characterization (2008)

Silicon nanoparticles were prepared and functionalized with alkene-terminated poly(ethylene oxide) to impart amphiphilic solution properties to the particles.