gebhart/patrepeval huggingface dataset:
A Scalable and Self-Configuring Architecture for Service Discovery in the Internet of Things (2014)

The Internet of Things (IoT) aims at connecting billions of devices in an Internet-like structure. This gigantic information exchange enables new opportunities and new forms of interactions among things and people. A crucial enabler of robust applications and easy smart objects' deployment is the availability of mechanisms that minimize (ideally, cancel) the need for external human intervention for configuration and maintenance of deployed objects. These mechanisms must also be scalable, since the number of deployed objects is expected to constantly grow in the next years. In this work, we propose a scalable and self-configuring peer-to-peer (P2P)-based architecture for large-scale IoT networks, aiming at providing automated service and resource discovery mechanisms, which require no human intervention for their configuration. In particular, we focus on both local and global service discovery (SD), showing how the proposed architecture allows the local and global mechanisms to successfully interact, while keeping their mutual independence (from an operational viewpoint). The effectiveness of the proposed architecture is confirmed by experimental results obtained through a real-world deployment.
Effect of high dose d-l propranolol on the renin-angiotensin system in glycerol induced acute renal failure in rat. (1978)

Stimulation of the renin-angiotensin system has been implicated in the pathogenesis of post-ischemic and nephrotoxic acute renal failure. This study was designed to determine the effect of d-l propranolol in glycerol induced acute renal failure in rats. 50% glycerol administered alone, induced a significant rise in blood urea and plasma renin concentration but no significant change in renal renin concentration. When administered with d-l propranolol (10 mg/kg body weight in 5 subcutaneous injections), mean blood urea, plasma renin and renal renin concentrations were not significantly different from the preceding group. Propranolol alone, administered in the same fashion, unexpectedly induced a rise in plasma renin concentration (p less than 0.05) while blood urea and renal renin concentrations were unchanged. Considering the unusually high dose of propranolol used, a second protocol was devised to compare the effects of d-l propranolol, in doses of 10 mg/kg and 1 mg/kg. Plasma renin concentration rose after high dose propranolol, but decreased, although not significantly, after administration of 1 mg/kg. Renal renin concentration was unchanged. High dose d-l propranolol, does not protect rats against glycerol induced acute renal failure. Contrarily to the usual 1 mg/kg dose, it was found surprisingly to increase renin release.
Approaches that mitigate doxorubicin-induced delayed adverse effects on mitochondrial function in rat hearts; liposome-encapsulated doxorubicin or combination therapy with antioxidant. (1995)

This experiment was designed to evaluate whether or not liposomal encapsulated-doxorubicin and combination therapy of free doxorubicin with coenzyme Q10, an antioxidant, mitigate the delayed adverse effects on cardiac muscle mitochondria. Rats aged 7 weeks were divided into the following four groups; rats were injected with doxorubicin or liposomal encapsulated-doxorubicin, total dose 15 mg/kg. The doxorubicin group consisted of two subgroups depending on diet, i.e., standard diet or 0.2% coenzyme Q10 diet. Mitochondria from cardiac muscles were prepared from rats aged 13 and 35 weeks. No significant decrease in the activity of complex I of the mitochondrial electron transport chain was observed in rats aged 13 weeks among the groups, however, significant decreases in the activity in rats aged 35 weeks were observed in the doxorubicin and liposomal doxorubicin groups compared with the corresponding control rats. In contrast, no significant change in complex I activity was observed in rats fed with coenzyme Q10 diet irrespective of doxorubicin treatment. From these results, not liposomal encapsulation of doxorubicin but combination therapy with antioxidant might be expected to reduce the delayed adverse effects of doxorubicin on heart mitochondria.
Biodegradation of polymers (2005)

Exhaustive studies on the degradation of plastics have been carried out in order to overcome the environmental problems associated with synthetic plastic waste. Recent work has included studies of the distribution of synthetic polymer-degrading microorganisms in the environment, the isolation of new microorganisms for biodegradation, the discovery of new degradation enzymes, and the cloning of genes for synthetic polymer-degrading enzymes. Under ambient conditions, polymers are known to undergo degradation, which results in the deterioration of polymer properties, characterized by change in its molecular weight and other physical properties. In this paper mainly the biodegradation of synthetic polymers such as polyethers, polyesters, polycaprolactones, polylactides, polylactic acid, polyurethane, PVA, nylon, polycarbonate, polyimide, polyacrylamide, polyamide, PTFE and ABS have been reviewed. Pseudomonas species degrade polyethers, polyesters, PVA, polyimides and PUR effectively. No microorganism has been found to degrade polyethylene without additives such as starch. None of the biodegradable techniques has become mature enough to become a technology yet.
Energy saving features of the Autoplex cellular telecommunications system (2002)

Autoplex is a cellular mobile telecommunications system that uses a distributed power system as part of its total approach to providing high quality, high availability communications. First, the Autoplex system is described briefly. Then, the contribution of its distributed power system to overall system availability is discussed. Finally, the contribution of dynamic power control to energy savings in the Autoplex system is described. A statistical model of the interaction of dynamic power control with mobile telephones and its effect on power drawn from the DC power plant is also presented. It relates the mobile telephone's physical location to the RF power level transmitted by the cellular system. The RF power, in turn, is related to the DC power drawn from the battery plant. This statistical model is based on the mobile telephone subscriber's physical position and is the basis for determining the energy savings in the Autoplex system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optical characterization of polymer liquid crystal cell exhibiting polymer blue phases (2007)

The optical properties of polymer liquid crystal cell exhibiting polymer blue phases (PBPs) have been determined using ultraviolet-visible spectrophotometry, polarizing optical microscopy (POM), differential scanning calorimetry (DSC), X-ray measurements, FTIR imaging and optical rotation technique. PBPs are thermodynamically stabile mesophases, which appear in chiral systems between isotropic and liquid crystal phases. A series of cyclosiloxane-based blue phase polymers were synthesized using a cholesteric LC monomer and a nematic LC monomer, and some of the polymers exhibit PBPs in temperature range over 300 degrees in cooling cycles. The unique property based on their structure and different twists formed and expect to open up new photonic application and enrich polymer blue phase contents and theory.
Editorial: Urothelial Malignancy--Much Promise But Little Progress (1996)

No AccessJournal of UrologyClinical Urology: Editorial1 Jan 1996Editorial: Urothelial Malignancy--Much Promise But Little Progress Robert R. Bahnson Robert R. BahnsonRobert R. Bahnson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66565-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial: Urothelial Malignancy--Much Promise But Little Progress." The Journal of Urology, 155(1), p. 122 Division of Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 155Issue 1January 1996Page: 122 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Robert R. Bahnson More articles by this author Expand All Advertisement PDF DownloadLoading ...
Induction of Glyoxylate Cycle Expression in <i>Caenorhabditis elegans</i>:  A Fasting Response throughout Larval Development (1997)

The mRNA and the bifunctional protein for the two glyoxylate cycle (GC) enzymes, isocitrate lyase and malate synthase, are expressed in a tissue- and stage-specific pattern in Caenorhabditis elegans. Since expression of the two enzymes for the carbon-conserving glyoxylate cycle is regulated by the availability of carbon sources in microorganisms, we have studied the bifunctional GCP gene expression under fasting conditions and in certain mutants of C. elegans in order to understand possible mechanisms regulating its expression during nematode development. The GCP mRNA and protein levels were elevated in early larvae which were never fed, a result consistent with previous enzyme activity measurements (Khan, F.R., & McFadden, B.A. (1982) Exp. Parasitol. 54, 48-54]. However, larvae of later stages also expressed higher levels of GCP mRNA and protein when they were shifted from normal to fasting growing conditions. The GCP expression appeared to be regulated primarily at the transcriptional level throughout development. Although the expression of both the GCP gene and lin-14 peaks at about the same time during development and are induced by fasting, the regulation of the GCP gene is independent of the heterochronic lin-14 control mechanism of postembryonic lineages, as demonstrated by the fact that there was no significant change of the GCP at both mRNA and protein levels in the heterochronic lin-4 (lf) and lin-14 (gf) mutants compared to the wild type.
Ability of the Human Cytomegalovirus IE1 Protein To Modulate Sumoylation of PML Correlates with Its Functional Activities in Transcriptional Regulation and Infectivity in Cultured Fibroblast Cells (2004)

In one of the earliest events in human cytomegalovirus (HCMV)-infected cells, the major immediate-early (IE) protein IE1 initially targets to and then disrupts the nuclear structures known as PML oncogenic domains (PODs) or nuclear domain 10. Recent studies have suggested that modification of PML by SUMO is essential to form PODs and that IE1 both binds to PML and may disrupt PODs by preventing or removing SUMO adducts on PML. In this study, we showed that in contrast to herpes simplex virus type 1 (HSV-1) IE110 (ICP0), the loss of sumoylated forms of PML by cotransfected IE1 was resistant to the proteasome inhibitor MG132 and that IE1 did not reduce the level of unmodified PML. Reduced sumoylation of PML was also observed in U373 cells after infection with wild-type HCMV and proved to require IE1 protein expression. Mutational analysis revealed that the central hydrophobic domain of IE1, including Leu174, is required for both PML binding and loss of PML sumoylation and confirmed that all IE1 mutants tested that were deficient in these functions also failed both to target to PODs and to disrupt PODs. These same mutants were also inactive in several reporter gene transactivation assays and in inhibition of PML-mediated repression. Importantly, a viral DNA genome containing an IE1 gene with a deletion [IE1(Delta290-320)] that was defective in these activities was not infectious when transfected into permissive fibroblast cells, but the mutant IE1(K450R), which is defective in IE1 sumoylation, remained infectious. Our mutational analysis strengthens the idea that interference by IE1 with both the sumoylation of PML and its repressor activity requires a physical interaction with PML that also leads to disruption of PODs. These activities of IE1 also correlate with several unusual transcriptional transactivation functions of IE1 and may be requirements for efficient initiation of the lytic cycle in vivo.
An Evaluation of liquid metal leak detection methods for the Clinch River Breeder Reactor Plant (1977)

This report documents an independent review and evaluation of sodium leak detection methods described in the Clinch River Breeder Reactor Preliminary Safety Analysis Report. Only information in publicly available documents was used in making the assessments.
Superconductivity in a Ln-Pb-Sr-Ca-Cu-O System (1989)

The superconductivity and crystal structure of a Ln-Pb-Sr-Ca-Cu-O system, where Ln=Y or lanthanide, have been studied. The maximum onset temperature and zero resistance obtained for a nominal composition of YbPbSr 2 Ca 2 Cu 3 O x were 78 K and 64 K, respectively. This ceramic is composed of a new phase which has a tetragonal symmetry with a =3.81 Å and c =15.7 Å, and a second phase, Yb 2 SrO 4 .
High-Fidelity Translation of Recombinant Human Hemoglobin in <i>Escherichia coli</i> (1998)

Coexpression of di-alpha-globin and beta-globin in Escherichia coli in the presence of exogenous heme yielded high levels of soluble, functional recombinant human hemoglobin (rHb1.1). High-level expression of rHb1.1 provides a good model for measuring mistranslation in heterologous proteins. rHb1.1 does not contain isoleucine; therefore, any isoleucine present could be attributed to mistranslation, most likely mistranslation of one or more of the 200 codons that differ from an isoleucine codon by 1 bp. Sensitive amino acid analysis of highly purified rHb1.1 typically revealed < or = 0.2 mol of isoleucine per mol of hemoglobin. This corresponds to a translation error rate of < or = 0.001, which is not different from typical translation error rates found for E. coli proteins. Two different expression systems that resulted in accumulation of globin proteins to levels equivalent to approximately 20% of the level of E. coli soluble proteins also resulted in equivalent translational fidelity.
Weakly Supervised Prostate TMA Classification via Graph Convolutional Networks (2019)

Histology-based grade classification is clinically important for many cancer types in stratifying patients distinct treatment groups. In prostate cancer, the Gleason score is a grading system used to measure the aggressiveness of prostate cancer from the spatial organization of cells and the distribution of glands. However, the subjective interpretation of Gleason score often suffers from large interobserver and intraobserver variability. Previous work in deep learning-based objective Gleason grading requires manual pixel-level annotation. In this work, we propose a weakly-supervised approach for grade classification in tissue micro-arrays (TMA) using graph convolutional networks (GCNs), in which we model the spatial organization of cells as a graph to better capture the proliferation and community structure of tumor cells. As node-level features in our graph representation, we learn the morphometry of each cell using a contrastive predictive coding (CPC)-based self-supervised approach. We demonstrate that on a five-fold cross validation our method can achieve $0.9659\pm0.0096$ AUC using only TMA-level labels. Our method demonstrates a 39.80\% improvement over standard GCNs with texture features and a 29.27% improvement over GCNs with VGG19 features. Our proposed pipeline can be used to objectively stratify low and high risk cases, reducing inter- and intra-observer variability and pathologist workload.
Enhancement of protein secretion in <i>Pichia pastoris</i> by overexpression of protein disulfide isomerase (2005)

A potential vaccine candidate, Necator americanus secretory protein (Na-ASP1), against hookworm infections, has been expressed in Pichia pastoris. Na-ASP1, a 45 kDa protein containing 20 cysteines, was directed outside the cell by fusing the protein to the preprosequence of the alpha-mating factor of Saccharomyces cerevisiae. Most of the protein produced by single copy clones was secreted outside the cell. However, increasing gene copy number of Na-ASP1 protein in P. pastoris saturated secretory capacity and therefore, decreased the amount of secreted protein in clones harboring multiple copies of Na-ASP1 gene. Overexpression of the endoplasmic reticulum (ER) resident, homologous chaperone protein, protein disulfide isomerase (PDI) was able to increase the secretion of (Na-ASP1) protein in high copy clones. The effect of PDI levels on secretion of Na-ASP1 protein was examined in clones with varying copy number of PDI gene. Increase in secreted Na-ASP1 secretion is correlated well with the PDI copy number. Increasing levels of PDI also increased overall Na-ASP1 protein production in all the clones. Nevertheless, there was still accumulation of intracellular Na-ASP1 protein in P. pastoris clones over-expressing Na-ASP1 and PDI proteins.
Integrity based relationships and trustworthy communication between network participants (2014)

Establishing trust relationships between network participants by having them prove their operating system's integrity via a Trusted Platform Module (TPM) provides interesting approaches for securing local networks at a higher level. In the introduced approach on OSI layer 2, attacks carried out by already authenticated and participating nodes (insider threats) can be detected and prevented. Forbidden activities and manipulations in hard- and software, such as executing unknown binaries, loading additional kernel modules or even inserting unauthorized USB devices, are detected and result in an autonomous reaction of each network participant. The provided trust establishment and authentication protocol operates independently from upper protocol layers and is optimized for resource constrained machines. Well known concepts of backbone architectures can maintain the chain of trust between different kinds of network types. Each endpoint, forwarding and processing unit monitors the internal network independently and reports misbehaviours autonomously to a central instance in or outside of the trusted network.
An advanced accounting service for AIX Systems (2005)

Resource usage is important input for a number of IT processes including those related to: financial management, capacity planning; service level management; and configuration management. Accounting systems in traditional UNIX/Linux environments generate a usage record at the end of each process. Administrators periodically use standard accounting system utilities to summarize resource usage using the user and application data recorded with each of these records. Recent advances in dynamic LPAR technologies and service oriented architectures have placed new requirements on the metering of resource usage. In a Dynamic LPAR environment, allocations must be measured and processed to obtain accurate information on resource usage. Transactions performed using service oriented architectures deployed on heterogeneous, distributed systems introduce new challenges for metering resource usage based on transaction classes. In this paper we present the design and implementation of a J2EE-based accounting service which exposes manageability and reporting interfaces for the AIX advanced accounting system. The reporting interface can be used to generate process-based, LPAR-based and transaction-based usage reports.
Chromatin Assembly Factor-1, a Marker of Clinical Value to Distinguish Quiescent from Proliferating Cells (2004)

Histone synthesis and chromatin assembly are mainly associated with DNA replication and are thus intimately involved in cell cycle regulation. The expression of key components involved in these events in human cells was studied in relation to cell-proliferative status. Among several chromatin assembly factors, chromatin assembly factor (CAF)-1 stood out as the most discriminating marker of the proliferative state. We show, using both immunofluorescence and Western blot analysis, that the expression of both CAF-1 large subunits, p150 and p60, is massively down-regulated during quiescence in several cell lines. Upon exit from the quiescent state, the CAF-1 subunits are re-expressed early, before DNA replication. The amounts of either total or chromatin-associated pools of CAF-1 proteins correlate directly with cell proliferation. Regulation of CAF-1 expression is partly controlled at the RNA level, as shown by quantitative reverse transcription-PCR and Northern blot experiments. Biological material from benign and malignant human breast tumors analyzed by immunocytochemistry and immunohistochemistry exhibits a strong positive correlation between CAF-1 p60 expression and the following proliferation markers: S-phase fraction (r = 0.84, P < 0.0001); Ki-67 (r = 0.94, P < 0.0001); and proliferating cell nuclear antigen (r = 0.95, P = 0.0001). We discuss the advantages of using CAF-1 to assess cell proliferation. High CAF-1 p60 levels are also shown to be associated with various prognostic factors. Our data highlight the precise association of CAF-1 expression with the proliferative state and validate the use of this factor as a useful proliferation marker and prognostic indicator in malignant and benign breast lesions.
Increased Vulnerability of Hippocampal Neurons from Presenilin‐1 Mutant Knock‐In Mice to Amyloid β‐Peptide Tox (1999)

Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Overexpression of PS1 mutations in cultured PC12 cells increases their vulnerability to apoptosis-induced trophic factor withdrawal and oxidative insults. We now report that primary hippocampal neurons from PS1 mutant knock-in mice, which express the human PS1M146V mutation at normal levels, exhibit increased vulnerability to amyloid beta-peptide toxicity. The endangering action of mutant PS1 was associated with increased superoxide production, mitochondrial membrane depolarization, and caspase activation. The peroxynitrite-scavenging antioxidant uric acid and the caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone protected hippocampal neurons expressing mutant PS1 against cell death induced by amyloid beta-peptide. Increased oxidative stress may contribute to the pathogenic action of PS1 mutations, and antioxidants may counteract the adverse property of such AD-linked mutations.
ABO-Incompatible Kidney Transplantation (2004)

When a renal transplant candidate's only medically-acceptable living kidney donor is ABO incompatible, the most common practice is to place them on the deceased donor list. Over the past few years, the implementation of paired kidney donor exchange programs and the development of protocols to overcome the ABO blood group barrier have become much more successful and widespread. Here we review the therapeutic options for patients whose only living kidney donor is ABO incompatible, with a specific emphasis on the rationale for and the current outcomes of ABO incompatible living donor kidney transplantation.
Assessing the Function of the Aging Adult (1968)

Journal Article Assessing the Function of the Aging Adult Get access Sandra C. Howell, M.P.H. Sandra C. Howell, M.P.H. Project Director 2Functional Appraisal of Aging Individuals, Gerontological Society110 S. Central Ave., St. Louis, Mo. 63105 Search for other works by this author on: Oxford Academic PubMed Google Scholar The Gerontologist, Volume 8, Issue 1_Part_1, Spring 1968, Pages 60–62, https://doi.org/10.1093/geront/8.1_Part_1.60 Published: 01 March 1968