gebhart/patrepeval huggingface dataset:
Status epilepticus: a modern approach to management (2008)

Status epilepticus (SE) is a common medical emergency. Two problems continue to militate against improved outcome in SE, namely, failure to recognize the wide spectrum of clinical presentation and failure to treat in an appropriately aggressive and timely manner. In this study, we aim to provide a clear understanding of the clinical presentation of SE, as well as providing an evidence-based review of the pathophysiological consequences of prolonged seizures, enabling the reader to adopt a rational approach to its management. We discuss current best practice for the management of SE as well as discussing alternative strategies, and briefly explore possible future therapeutic interventions.
Fast range image-based segmentation of sparse 3D laser scans for online operation (2016)

Object segmentation from 3D range data is an important topic in mobile robotics. A robot navigating in a dynamic environment needs to be aware of objects that might change or move. A segmentation of the laser scans into individual objects is typically the first processing step before a further analysis is performed. In this paper, we present a fast method that segments 3D range data into different objects, runs online, and has small computational demands. Our approach avoids the explicit computation of the 3D point cloud and performs all computations directly on a 2D range image, which enables a fast segmentation for each scan. A further relevant aspect of our method is that we can segment objects even if the 3D data is sparse. This is important for scanners such as the new Velodyne Puck. We implemented our approach in C++ and ROS and thoroughly tested it using different 3D scanners. Our method can operate at over 100 Hz for the 64-beam Velodyne scanner on a single core of a mobile CPU while producing high quality segmentation results. In addition to this, we make the source code for the approach available.
Reviews (2011)

Europe in the Rotmdis a hypertextuall hypergraphical database of facts about Europe, biased towards education and training, but taking in its stride many peripheral areas relevant to anyone considering living and/or working in, or even visiting, a member state of the EU - population, economy, institutions, geography, climate and so forth - all making up thousands of interconnected screens. These screens contain maps with a selection of zooms and hotspots, all kinds of facts and figures about available educational and vocational courses (presented both textually and, where appropriate, as graphs, bar charts and such like), details of life in each EU member state, details of cities and what they have to offer, and a lot more. There are also extra facilities, such as being able to set currency exchange rates or to create customized notebooks.DOI:10.1080/0968776940020208
Smed-Evi/Wntless is required for β-catenin-dependent and-independent processes during planarian regeneration (2009)

Planarians can regenerate a whole animal from only a small piece of their body, and have become an important model for stem cell biology. To identify regenerative processes dependent on Wnt growth factors in the planarian Schmidtea mediterranea (Smed), we analyzed RNAi phenotypes of Evi, a transmembrane protein specifically required for the secretion of Wnt ligands. We show that, during regeneration, Smed-evi loss-of-function prevents posterior identity, leading to two-headed planarians that resemble Smed-beta-catenin1 RNAi animals. In addition, we observe regeneration defects of the nervous system that are not found after Smed-beta-catenin1 RNAi. By systematic knockdown of all putative Smed Wnts in regenerating planarians, we identify Smed-WntP-1 and Smed-Wnt11-2 as the putative posterior organizers, and demonstrate that Smed-Wnt5 is a regulator of neuronal organization and growth. Thus, our study provides evidence that planarian Wnts are major regulators of regeneration, and that they signal through beta-catenin-dependent and -independent pathways.
Effect of Curcumin on Proliferation of Human Retinal Endothelial Cells under In Vitro Conditions (2006)

These data suggest an underlying mechanism whereby curcumin induces the apoptosis in HRECs by the regulation of intracellular ROS generation, VEGF expression and release, and VEGF-mediated PKC-betaII translocation.
Why Internal Olefins are difficult to Sulphonate (1985)

Sulfonation d'heptadecene-8, octadecene-9 a l'aide du trioxyde de soufre dans un reacteur possedant une colonne a paroi mouillee. Obtention d'alcenesulfonates et des sultones
Complete Nucleotide Sequence and Analysis of the Locus of Enterocyte Effacement from Rabbit Diarrheagenic <i>Escherichia coli</i> RDEC-1 (2001)

The pathogenicity island termed the locus of enterocyte effacement (LEE) is found in diverse attaching and effacing pathogens associated with diarrhea in humans and other animal species. To explore the relation of variation in LEE sequences to host specificity and genetic lineage, we determined the nucleotide sequence of the LEE region from a rabbit diarrheagenic Escherichia coli strain RDEC-1 (O15:H-) and compared it with those from human enteropathogenic E. coli (EPEC, O127:H6) and enterohemorrhagic E. coli (EHEC, O157:H7) strains. Differing from EPEC and EHEC LEEs, the RDEC-1 LEE is not inserted at selC and is flanked by an IS2 element and the lifA toxin gene. The RDEC-1 LEE contains a core region of 40 open reading frames, all of which are shared with the LEE of EPEC and EHEC. orf3 and the ERIC (enteric repetitive intergenic consensus) sequence present in the LEEs of EHEC and EPEC are absent from the RDEC-1 LEE. The predicted promoters of LEE1, LEE2, LEE3, tir, and LEE4 operons are highly conserved among the LEEs, although the upstream regions varied considerably for tir and the crucial LEE1 promoter, suggesting differences in regulation. Among the shared genes, high homology (>95% identity) between the RDEC-1 and the EPEC and EHEC LEEs at the predicted amino acid level was observed for the components of the type III secretion apparatus, the Ces chaperones, and the Ler regulator. In contrast, more divergence (66 to 88% identity) was observed in genes encoding proteins involved in host interaction, such as intimin (Eae) and the secreted proteins (Tir and Esps). A comparison of the highly variable genes from RDEC-1 with those from a number of attaching and effacing pathogens infecting different species and of different evolutionary lineages was performed. Although RDEC-1 diverges from some human-infecting EPEC and EHEC, most of the variation observed appeared to be due to evolutionary lineage rather than host specificity. Therefore, much of the observed hypervariability in genes involved in pathogenesis may not represent specific adaptation to different host species.
The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development (2001)

Nodal proteins have crucial roles in mesendoderm formation and left-right patterning during vertebrate development. The molecular mechanisms of signal transduction by Nodal and related ligands, however, are not fully understood. In this paper, we present biochemical and functional evidence that the orphan type I serine/threonine kinase receptor ALK7 acts as a receptor for mouse Nodal and Xenopus Nodal-related 1 (Xnr1). Receptor reconstitution experiments indicate that ALK7 collaborates with ActRIIB to confer responsiveness to Xnr1 and Nodal. Both receptors can independently bind Xnr1. In addition, Cripto, an extracellular protein genetically implicated in Nodal signaling, can independently interact with both Xnr1 and ALK7, and its expression greatly enhances the ability of ALK7 and ActRIIB to respond to Nodal ligands. The Activin receptor ALK4 is also able to mediate Nodal signaling but only in the presence of Cripto, with which it can also interact directly. A constitutively activated form of ALK7 mimics the mesendoderm-inducing activity of Xnr1 in Xenopus embryos, whereas a dominant-negative ALK7 specifically blocks the activities of Nodal and Xnr1 but has little effect on other related ligands. In contrast, a dominant-negative ALK4 blocks all mesoderm-inducing ligands tested, including Nodal, Xnr1, Xnr2, Xnr4, and Activin. In agreement with a role in Nodal signaling, ALK7 mRNA is localized to the ectodermal and organizer regions of Xenopus gastrula embryos and is expressed during early stages of mouse embryonic development. Therefore, our results indicate that both ALK4 and ALK7 can mediate signal transduction by Nodal proteins, although ALK7 appears to be a receptor more specifically dedicated to Nodal signaling.
Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis (1992)

Although increasingly unlikely, the possibility of a scrapie-specific nucleic acid carried by infectious prion particles is still unresolved. Return refocusing gel electrophoresis was developed to detect homogeneous and heterogeneous nucleic acids extracted from highly purified scrapie prion preparations. This method was improved with respect to the size range from 13 to 1100 nucleotides (nt) over which analyses could be performed. The yield of nucleic acid, particularly of small DNA oligonucleotides and polyadenylated RNA, was determined after deproteinization and two-phase extraction. Despite extensive nuclease digestions some small polynucleotides remained. Although a scrapie-specific nucleic acid cannot be excluded, the results further define the possible characteristics of a hypothetical molecule. If homogeneous in size, such a molecule would be <80 nt in length at a particle-to-infectivity ratio near unity, if heterogeneous, scrapie-specific nucleic acids would have to include molecules smaller than 240 nt.
Pipelined, time-sharing access technique for an integrated multiport memory (1991)

A pipelined, time-sharing access (PTA) technique that realizes an integrated multiport memory for high-speed signal processing is described. N/2-port memory cells, with less area and a wider operating margin, are used for the N-port memory function. Memory cell access for multiple ports is performed serially within one cycle, instead of being an ordinary parallel operation. Memory operation is divided into three pipeline cycles-address selection, memory cell access, and data I/O operation-to reduce the cycle time. A 64-kb four-port memory was fabricated with conventional two-port memory cells to verify the effectiveness of this technique. A 16 ns memory operation with a wide margin was observed under a 3 V supply voltage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Filtration solutions for medical devices (2005)

Filtration + Separation begins a three-part look at filtration technology used for medical devices. In part 1 below, Helen Vogt of Sefar Inc reminds us that as well as the development of nonwovens in the field, there are still important filtering technologies that use woven filters within the medical sector.
Engineered Fetal Cardiac Graft Preserves Its Cardiomyocyte Proliferation Within Postinfarcted Myocardium and Sustains Cardiac Function (2010)

The goal of cellular cardiomyoplasty is to replace damaged myocardium by healthy myocardium achieved by host myocardial regeneration and/or transplantation of donor cardiomyocytes (CMs). In the case of CM transplantation, studies suggest that immature CMs may be the optimal cell type to survive and functionally integrate into damaged myocardium. In the present study, we tested the hypothesis that active proliferation of immature CMs contributes graft survival and functional recovery of recipient myocardium. We constructed engineered cardiac tissue from gestational day 14 rat fetal cardiac cells (EFCT) or day 3 neonatal cardiac cells (ENCT). Culture day 7 EFCTs or ENCTs were implanted onto the postinfarct adult left ventricle (LV). CM proliferation rate of EFCT was significantly higher than that of ENCT at 3 days and 8 weeks after the graft implantation, whereas CM apoptosis rate remained the same in both groups. Echocardiogram showed that ENCT implantation sustained LV contraction, whereas EFCT implantation significantly increased the LV contraction at 8 weeks versus sham group (p < 0.05, analysis of variance). These results suggest that active CM proliferation may play a critical role in immature donor CM survival and the functional recovery of damaged recipient myocardium.
Congenital Abnormalities of the Lymphatic System: A New Clinical Classification (1990)

The numerous clinical presentations of congenital abnormalities of the lymphatic system in children and the confusing terminology used to describe their pathologic diagnoses impede the physician's understanding of the condition. The clinical classification based on the actual symptoms of the congenital problems we have presented here should help the physician identify the specific abnormality and a potential treatment. Future research should concentrate on the specific causes and the treatment of these congenital abnormalities.
A fault location technique for two and three terminal lines using high frequency fault clearing transients (2003)

This paper suggests that a voltage recorder, placed next to a circuit breaker not as usual on the side of the substation, but on the side of the transmission line, may reveal the location of permanent faults. Two different approaches on estimating the fault location are presented here: a frequency domain approach and a time domain approach. These methods are tested and compared with simulations of typical transmission systems using the Electromagnetic Transients Program (EMTP). Two typical line configurations are considered: two terminal lines and three terminal lines.
A single-chip digital signaling interface for the DSI intraoffice environment (2003)

A single-chip data transceiver meeting the DSI (Digital Signaling Interface) (1.544 Mb/s) intraoffice requirements is presented. The DSI provides receive-pulse regeneration, timing recovery, and transmit-pulse rate pre-equalization along with alarm and status monitoring for a four-wire, full-duplex communication link over twisted pair. It contains a transmit driver circuit which reduces chip power consumption to 115 mW, about one third the power of existing devices. A monolithic clock multiplier circuit creates internal chip timing edges at 4*1.544 MHz, obviating the need for an external crystal-based timing reference. A data-latching circuit is used in the receive phase-locked loop (PLL) to improve input jitter accommodation. The DSI, designed in a 1.75- mu m CMOS process, occupies 20 mm/sup 2/ of silicon and operates from a 5-V (+or-10%) supply from a -40 to +85 degrees C.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Determination of critical conditions for the esterification of acetic acid with ethanol in the presence of carbon dioxide (2006)

In this work, we present the calculation of critical coordinates for the esterification of acetic acid with ethanol in compressed carbon dioxide. Determination of the critical pressure for this system is useful, since the conversion of this reaction increases with pressure in the two-phase region, reaching a maximum at the critical point. We used a calculation framework based on a coordinate transformation for molar fractions, producing a new compositional domain. For a system with five components (acetic acid + ethanol + ethyl acetate + water + carbon dioxide) and one equilibrium reaction, the compositional domain is entirely described by three independent transformed coordinates. The results obtained were compared with experimental observations presented in the literature. The results illustrate the capability of the framework used to determine critical coordinates for reactive systems, and thus its usefulness as a tool for pressure tuning for this esterification reaction in compressed carbon dioxide.
K-mer clustering algorithm using a MapReduce framework: application to the parallelization of the Inchworm module of Trinity (2017)

Our study shows that MapReduce-based clustering has great potential for distributing challenging sequencing problems, without loss of accuracy. Although we have focussed on the Trinity package, we propose that such clustering is a useful initial step for other assembly pipelines.
<title>High-speed correspondence for object recognition and tracking</title> (1997)

Real-time measurement using multi-camera 3D measuring system requires three major components to operate at high speed: image data processing; correspondence; and least squares estimation. This paper is based upon a system developed at City University which uses high speed solutions for the first and last elements, and describes recent work to provide a high speed solution to the correspondence problem. Correspondence has traditionally been solved in photogrammetry by using human stereo fusion of two views of an object providing an immediate solution. Computer vision researchers and photogrammetrists have applied image processing techniques and computers to the same configuration and have developed numerous matching algorithms with considerable success. Where research is still required, and the published work is not so plentiful, is in the area of multi-camera correspondence. The most commonly used methods utilize the epipolar geometry to establish the correspondences. While this method is adequate for some simple situations, extensions to more than just a few cameras are required which are reliable and efficient. In this paper the early stages of research into reliable and efficient multi-camera correspondence method for high speed measurement tasks are reported.
A Fortran program for analysis of ellipsometer measurements (1969)

A general Fortran program is given that performs the calculations required to analyze ellipsometer measurements. This program replaces the program given in NBS Technical Note 242, entitled "A Fortran Program for Analysis of Ellipsometer Measurements and Calcula- tion of Reflection Coefficients From Thin Films." The main changes from the previous program are: 1) the new program is in Fortran IV and V rather than Fortran II; 2) the relative transmission of the wave plate is considered in analyzing ellipsometer readings; 3) an improved method is used for calculating the refractive index of a film; 4) the form of the input data is improved; 5) a method for calculating and correcting for tilt of the reflecting surface is given; 6) an improved method of calculating confidence limits for the calculated values of thickness and refractive index of a film is used; and 7) a method for calculating the optical constants of an adsorbing film of given thickness is included.
ChemInform Abstract: SYNTHESIS AND ANTHELMINTIC ACTIVITY OF ALKYL‐(5‐ACYL‐1H‐BENZIMIDAZOL‐2‐YL)CARBAMATES (1978)

Abstract Die aus den Nitrobenzophenonen (I) durch Umsetzung mit Ammoniak und anschließende Reduktion hergestellten o‐Diaminobenzophenone (III) werden mit Iminomethylcarbamaten (III) zu Benzimidazolen (IV) cyclisiert.
Manifestation of symptomatic congenital cytomegalovirus infection and gancyclovir effect (2012)

Objective 
To determine the clinical manifestation of congenital cytomegalovirus (CMV) infection and the effect of gancyclovir.
Methodology 
Twenty newborns with congenital CMV infection were admitted at Queen Rania Hospital (KHMC) between January 2009 and December 2010 and were treated with Gancyclovir were included in the study.
Result 
The most common clinical presentation was intrauterine growth retardation (45%), Hepatosplenomegaly (35%), Chorioretinites (35%) and purpuric skin rash (25%). Brain MRI was positive in 20%. Complete blood count was abnormal in 20%. More than 75% patients improved with gancyclovir without any complications. 
Conclusion 
Intrauterine growth retardation, hepatosplenomegaly and chorioretinites were commonest clinical manifestations of CMV infection. Gancyclovir was effective. Prevention of congenital CMV infection by immunization of symptomatic women who are at risk of primary infection during gestation should be emphasized. (Rawal Med J 2012;37:18-20).
Significant modification of lipid metabolism in aged persons following the treatment with a nutritive supplement containing embryonary peptides--preliminary results. (2005)

HUMANOFORT is a nutritive supplement extracted and purified from embryonated chicken eggs according to an original procedure under licence. Humanofort received the suitable consent from the Romanian Ministry of Health. The main components of Humanofort are two oligopeptides of 5,000 and 10,000 D molecular weight. 40 subjects aged 50-75 years (18 men and 22 women) consumed, daily, 4 caps of Humanofort for 60 days. The samples of blood from each subject were obtained before and after treatment. Therefore, each subject was his own control. In all subjects, after treatment, total cholesterol and LDL-cholesterol decreased approximately 30% as compared with the initial values. In 80% of patients, an increase of HDL cholesterol and a decrease of the insulin level in blood were also observed. After treatment, the cardiac risk factors (Aethna 2000 Program), such as total cholesterol/HDL and Apolipoproteins B/A were shifted towards lower range. These long-lasting modifications have an adaptative-regulatory character and seem to be produced by the growth factors contained in Humanofort.
Distributed Traveling-Wave-Based Fault-Location Algorithm Embedded in Multiterminal Transmission Lines (2018)

A novel traveling-wave-based fault-location algorithm for multiterminal transmission lines is introduced in this paper. Existing traveling-wave fault-location methods that based on the data measured at line terminals lack reliability and accuracy because time synchronization is needed, which brings error. To solve this problem, the complex structure of multiterminal power system is divided into several fault identification branches, current at the midpoint of each branched is measured, a novel fault-location algorithm is proposed, and the time synchronization error is eliminated. A line-based device is designed to measure the current at the midpoint of each branch. An accurate value of the traveling wave speed can be obtained by merely applying the data record in one measuring device. Thus, the fault-location accuracy is improved. The system model applied in this paper comprises one transmission line and two tapped lines, and the proposed method applies to networks with more terminals. Performance of this method is tested by different cases by PSCAD. The hardware platform has been tested in Sichuan Province, China.
Analysis of laser pulse chirping in mode-locked vertical cavity surface-emitting lasers (1993)

Mode-locked vertical cavity lasers have a large cross-sectional area and consequently a large saturation energy and large peak powers. The authors analyze excess optical bandwidth generation in these lasers and find that self-phase modulation due to optical pumping and gain saturation is the dominant factor in inducing laser pulse chirping. The large magnitude of the chirp makes intracavity prism-pair compensation difficult. Adjustment of the cavity length has a major impact on the pulse chirping, as observed experimentally. Proper adjustment can result in a large linear frequency chirp which can be compensated using external pulse compression techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>