gebhart/patrepeval huggingface dataset:
Subacute Toxicity of a Novel Inhibitor of Acyl-CoA: Cholesterol Acyltransferase in Beagle Dogs (1993)

PD 132301–2 is a substituted urea hypolipidemic and antiatherosclerotic agent that is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). To determine its subacute toxicity, PD 132301–2 was administered orally to beagle dogs at 0, 6, 12, 25, 50, 200, 400, or 800 mg/kg/day for 2 weeks. Clinicopathologic evaluations were completed on all dogs. Liver and adrenal total and esterified cholesterol concentrations, adrenocorticotrophic hormone (ACTH) responsiveness, and adrenal ultrastructure were determined at 0, 6, 12, and 25 mg/kg. At 12 mg/kg or greater, salivation, epiphora, conjunctivitis, emesis, anorexia or decreased food consumption, and soft to mucoid feces and/or diarrhea were noted. Suppression of ACTH response occurred by Day 6 at all doses. Adrenocortical degeneration and/or necrosis in zona fasciculata and reticularis was seen at all doses; adrenal free and esterified cholesterol were normal at 6 mg/kg and decreased at 12 and 25 mg/kg. Increases in serum alanine aminotransferase (2- to 15-fold), aspartate aminotransferase (2- to 12-fold), and alkaline phosphatase (2- to 7-fold) were noted at 50 mg/kg or greater. Periportal hepatocellular hypertrophy and hypereosinophilia occurred at 50 mg/kg or greater; hepatic cholesterol values were not significantly affected by treatment. Dose-dependent ultrastructural alterations in adrenocortical cells included decreased numbers of mitochondria and smooth endoplasmic reticulum profiles, qualitative and quantitative changes in lipid globules, and increased numbers of autolysosomes. PD 132301-2 or one of its metabolites has potent adrenocorticolytic properties and limited hepatotoxic properties by mechanism(s) that are likely independent of systemic ACAT inhibition.
Structure of Hassmarin, a Novel Biscoumarin from a Citrus Plant. (1993)

The acetone extract of the root of Citrus hassaku Hort. ex TANAKA (Rutaceae) was subjected to silica gel column and preparative thin layer chromatographies to obtain a new binary coumarin (biscoumarin) named hassmarin (1). The structure, corresponding to a Diels-Alder type adduct of demethyl derivatives of phebalosin (6) and trans-dehydroosthol (8), was assigned on the basis of spectral analyses.
The Low-Q Diffractometer at the Los Alamos Neutron Scattering Center (1990)

Abstract The Low-Q Diffractometer at the Los Alamos Neutron Scattering Center is now operational, and a variety of calibration experiments have been performed. A description of the instrument is presented, emphasizing its special and unique features. In particular, the “dynamic gravity focusing” device has been demonstrated to extend the useful wavelength range to values which would otherwise fall below the beam stop onto the detector. The downstream monitor in the beam stop has also been demonstrated, allowing data reduction even from strongly scattering samples without the necessity of a separate transmission measurement. Examples of data as displayed to users during data acquisition from various experiments shown. Procedures to combine data from a wide wavelength range into Q space are discussed, and three examples are shown which illustrate the dynamic range of the instrument.
Sub-20 ps ECL circuits with high-performance super self-aligned selectively grown SiGe base (SSSB) bipolar transistors (1995)

This paper describes a high maximum frequency of oscillation f/sub max/ self-aligned SiGe-base bipolar transistor technology, based on a self-aligned selective epitaxial growth (SEG) technology including graded Ge profile in an intrinsic base and link-base engineering using a borosilicate glass (BSG) sidewall structure. The transistor is a new self-aligned transistor, which we call a Super Self-aligned Selectively grown SiGe Base (SSSB) bipolar transistor. The 1st step of the annealing (800/spl deg/C, 10 min) was performed for the diffusion of boron from the BSG film, before the deposition of an emitter polysilicon film. The 2nd step of the annealing (950/spl deg/C, 10 sec) of emitter drive-in was carried out, which enabled us to obtain sufficient current gain using in-situ phosphorus doped polysilicon as an emitter electrode. Sheet resistance for a link-region more than one order lower than that of the epitaxial intrinsic base was obtained after heat treatment. Base profile (boron and Ge) design, and the 2-step annealing technique have realized cut-off frequency f/sub T/ of 51 GHz and f/sub max/ of 50 GHz. ECL circuits of 19-psec gate delay have been achieved.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
EFFECT OF SPICES ON GROWTH AND SURVIVAL OF <i>SALMONELLA</i> TYPHIMURIUM DT 104 IN GROUND BEEF STORED AT 4 AND 8C (2006)

ABSTRACT Few studies have addressed the use of spices against pathogens associated with meat. The effects of garlic, ginger and turmeric were evaluated against Salmonella Typhimurium DT 104 that were inoculated either in spice paste or in buffered peptone water (BPW) or in heat‐treated ground beef and stored at 4 and 8C for 10 days. Data from the spice pastes study showed a decrease in Salmonella Typhimurium DT 104 counts, and the greatest reduction (3.39 log) was observed in garlic paste stored at 4C. Garlic in BPW data showed a reduction of 1.5 and 1.0 log in Salmonella Typhimurium counts at 4 and 8C, respectively. Ground beef stored at 4C showed no growth or a slight reduction in growth in samples with spice, while all samples at 8C showed an increase in Salmonella Typhimurium counts. Results show that the spices inhibit or inactivate Salmonella Typhimurium DT 104 when they are in direct contact. However, when spices are added to a complex food system such as ground beef, the inhibitory activity of these spices considerably decreases.
Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects (2020)

Cytosine base editors (CBEs) enable efficient cytidine-to-thymidine (C-to-T) substitutions at targeted loci without double-stranded breaks. However, current CBEs edit all Cs within their activity windows, generating undesired bystander mutations. In the most challenging circumstance, when a bystander C is adjacent to the targeted C, existing base editors fail to discriminate them and edit both Cs. To improve the precision of CBE, we identified and engineered the human APOBEC3G (A3G) deaminase; when fused to the Cas9 nickase, the resulting A3G-BEs exhibit selective editing of the second C in the 5'-CC-3' motif in human cells. Our A3G-BEs could install a single disease-associated C-to-T substitution with high precision. The percentage of perfectly modified alleles is more than 6000-fold for disease correction and more than 600-fold for disease modeling compared with BE4max. On the basis of the two-cell embryo injection method and RNA sequencing analysis, our A3G-BEs showed minimum genome- and transcriptome-wide off-target effects, achieving high targeting fidelity.
Distribution of PG-M/Versican Variants in Human Tissues andde Novo Expression of Isoform V3 upon Endothelial Cell Activation, Migration, and Neoangiogenesis in Vitro (2002)

We have carried out a comprehensive molecular mapping of PG-M/versican isoforms V0-V3 in adult human tissues and have specifically investigated how the expression of these isoforms is regulated in endothelial cells in vitro. A survey of 21 representative tissues highlighted a prevalence of V1 mRNA; demonstrated that the relative frequency of expression was V1 > V2 > V3 >or= V2; and showed that <15% of the tissues transcribed significant levels of all four isoforms. By employing novel and previously described anti-versican antibodies we verified a ubiquitous versican deposition in normal and tumor-associated vascular structures and disclosed differences in the glycanation profiles of versicans produced in different vascular beds. Resting endothelial cells isolated from different tissue sources transcribed several of the versican isoforms but consistently failed to translate these mRNAs into detectable proteoglycans. However, if stimulated with tumor necrosis factor-alpha or vascular endothelial growth factor, they altered their versican expression by de novo transcribing the V3 isoform and by exhibiting a moderate V1/V2 production. Induced versican synthesis and de novo V3 expression was also observed in endothelial cells elicited to migrate in a wound-healing model in vitro and in angiogenic endothelial cells forming tubule-like structures in Matrigel or fibrin clots. The results suggest that, independent of the degree of vascularization, human adult tissues show a limited expression of versican isoforms V0, V2, and V3 and that endothelial cells may contribute to the deposition of versican in vascular structures, but only following proper stimulation.
70/30 Insulin Algorithm Versus Sliding Scale Insulin (2005)

Glycemic control with the 70/30 insulin algorithm was superior to traditional SSI dosing.
DB2 Spatial Extender - Spatial data within the RDBMS (2001)

Much of the data that we encounter has a spatial (geographic locational) aspect yet this has not been readily exploited by traditional RDBMS. Over the past five years there has been a confluence of Geographic Information System (GIS) technology, RDBMS architecture and SQL standards that has fostered the implementation of spatial processing within the RDBMS. This paper will present a brief overview of spatial processing and the evolution of technology leading to the development of the IBM DB2 Spatial Extender that exploits the IBM DB2 Universal Database (UDB) object-relational support to implement a standards-based SQL spatial capability.
General operational review of textbooks (1985)

Recent research demonstrates that textbooks are one of the most effective school inputs. This paper reviews the Bank's experience with textbooks, highlighting the technical and complex nature of book provision systems. Key issues raised are financial feasibility of textbook provision, coordination between curriculum and textbook development, book quality and teacher training. The importance of adopting a comprehensive and long-term perspective in project planning is stressed. The paper also addresses several project shortcomings such as inadequate distribution systems and poor quality books. The paper concludes with a set of recommendations for resolving the problems in project preparation and implementation.
Optogenetic control of phosphoinositide metabolism (2012)

Phosphoinositides (PIs) are lipid components of cell membranes that regulate a wide variety of cellular functions. Here we exploited the blue light-induced dimerization between two plant proteins, cryptochrome 2 (CRY2) and the transcription factor CIBN, to control plasma membrane PI levels rapidly, locally, and reversibly. The inositol 5-phosphatase domain of OCRL (5-ptase(OCRL)), which acts on PI(4,5)P(2) and PI(3,4,5)P(3), was fused to the photolyase homology region domain of CRY2, and the CRY2-binding domain, CIBN, was fused to plasma membrane-targeting motifs. Blue-light illumination (458-488 nm) of mammalian cells expressing these constructs resulted in nearly instantaneous recruitment of 5-ptase(OCRL) to the plasma membrane, where it caused rapid (within seconds) and reversible (within minutes) dephosphorylation of its targets as revealed by diverse cellular assays: dissociation of PI(4,5)P(2) and PI(3,4,5)P(3) biosensors, disappearance of endocytic clathrin-coated pits, nearly complete inhibition of KCNQ2/3 channel currents, and loss of membrane ruffling. Focal illumination resulted in local and transient 5-ptase(OCRL) recruitment and PI(4,5)P(2) dephosphorylation, causing not only local collapse and retraction of the cell edge or process but also compensatory accumulation of the PI(4,5)P(2) biosensor and membrane ruffling at the opposite side of the cells. Using the same approach for the recruitment of PI3K, local PI(3,4,5)P(3) synthesis and membrane ruffling could be induced, with corresponding loss of ruffling distally to the illuminated region. This technique provides a powerful tool for dissecting with high spatial-temporal kinetics the cellular functions of various PIs and reversibly controlling the functions of downstream effectors of these signaling lipids.
Some 6,8-dibromo-S-substituted-2-mercapto-3-aryl(or alkyl)-4-quinazolones (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome 6,8-dibromo-S-substituted-2-mercapto-3-aryl(or alkyl)-4-quinazolonesP. N. Bhargava and M. R. ChaurasiaCite this: J. Med. Chem. 1968, 11, 2, 404–405Publication Date (Print):March 1, 1968Publication History Published online1 May 2002Published inissue 1 March 1968https://pubs.acs.org/doi/10.1021/jm00308a067https://doi.org/10.1021/jm00308a067research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of an organic adduct of the P4O10 cage structure (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of an organic adduct of the P4O10 cage structureThomas Glonek, Terrell C. Myers, and John R. Van WazerCite this: J. Am. Chem. Soc. 1975, 97, 1, 206–207Publication Date (Print):January 1, 1975Publication History Published online1 May 2002Published inissue 1 January 1975https://pubs.acs.org/doi/10.1021/ja00834a046https://doi.org/10.1021/ja00834a046research-articleACS PublicationsRequest reuse permissionsArticle Views120Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Eye tracking and gaze vector calculation within immersive virtual environments (2007)

Human vision is arguably our most powerful sense, with our eyes constantly darting around in an almost subconscious manner to create a complete picture of the visual scene around us. These movements can unveil information about the way the brain is processing the incoming visual data into its mental image of our surroundings.
The function and mechanism of TH 17 cells in aGVHD early diffuse lung injury (2011)

Objective To assess the functional role of TH 17 cells in allogeneic hematopoietic stem cell transplantation (allyHSCT).Methods Bone marrow monocytes and splenic T cells were enriched from C57/BL6 donors.Recipient Balb/c mice were irradiated with 7.5 Gy total body irradiation (TBI) and injected with 5 105 splenic T cells and 5 106 bone marrow monocytes.Survival was monitored daily,clinical graft-versus-host disease (GVHD) was assayed three times a week,and detailed histopathologic analyses of lung were performed at day six after Allo-HSCT.Flow cytometry analysis was performed using CD3-FITC,CD4-PE,CD45-PerCP-CyS.5 monoclonal antibodies.Cells were stained for intracellular cytokines using mouse TH 1/TH2/TH 17 cytokine kit.Results All the experimental animals showed GVHD manifestations on the day 6 after transplantation.Animals from BMT and HF groups were scarified and histological analysis of lung was performed.Absence of TH 17 cells induced severe pathologic pulmonary lesions.The histopathology of the lung tissue was characterized by disorganization,epithelia cell damage,interstitial fibroplasias,and monocytes infiltration.The proportion of TH1 and TH 17 in BMT group was (5.53 ± 0.11 ) ％ and ( 1.04 ± 0.34)％ respectively,both significantly different from that in HF group.The levels of IL-17A and IFN-γin BMT group were (2.81 ±0.19) and (42.97 ± 0.23) pg/mL respectively.IL-17A could not be detected in HF group,yet the level of IFN-y was only (9.89 ± 0.51 ) pg/mL.IL-10 in both HF and BMT groups was not detectable.Conclusion Lung is on target of aGVHD.IL-17A may play a key role in the lung injury after transplantation.

Key words: 
Hematopoietic stem cell transplantation;  Graft vs host disease;  Lung injury;  TH 17cells
Influence of electron donor and acceptor substituents on the excited state properties of rhenium(I) tetracarbonyl chelate complexes (1998)

The new complexes [Re(CO)4(meppy)], [Re(CO)4(dmdcb)]PF6 and [Re(CO)4(dmeob)][CF3SO3] [Hmeppy = 3-methyl-2-phenylpyridine, dmdcb = 4,4′-di(methoxycarbonyl)-2,2′-bipyridine and dmeob = 4,4′-dimethoxy-2,2′-bipyridine] have been synthesized. The crystal and molecular structure of [Re(CO)4(meppy)] was determined by X-ray diffraction. High-resolution optical absorption, luminescence and Raman spectroscopy on single crystals and glasses at cryogenic temperatures revealed the lowest excited state for all complexes as a nominally 3π–π* ligand centered state with some 1MLCT character mixed in by spin–orbit coupling. This leads to the occurrence of metal–ligand vibrational sidebands in the absorption and luminescence spectra. The lowest excited state has a charge-transfer character of 1.7, 1.3 and 1.0% for [Re(CO)4(meppy)], [Re(CO)4(dmdcb)]PF6 and [Re(CO)4(dmeob)][CF3SO3], respectively. These results are compared with those for the unsubstituted complexes [Re(CO)4(ppy)] and [Re(CO)4(bpy)]PF6 (Hppy = 2-phenylpyridine and bpy = 2,2′-bipyridine). The influence of the σ-donor group on the energy of the excited states and on the mixing of 1MLCT in the 3LC state is negligibly small. π-Electron donor substituents increase the energy of the excited states and increase the singlet–triplet splittings; π-electron withdrawing groups have the opposite effect and increase the 1MLCT character in the first excited state. The luminescence decay of [Re(CO)4(meppy)] is not single exponential due to a large inhomogeneous distribution of chromophores in the glass. This large distribution is due to the steric interaction of the methyl group with the phenyl part of the ligand.
Salinity Tolerance Mechanisms of Six C4 Turfgrasses (1994)

Physiological responses to salinity and relative salt tolerance of six C 4 turfgrasses were investigated. Grasses were grown in solution culture containing 1, 100, 200, 300, and 400 m m NaCl. Salinity tolerance was assessed according to reduction in relative shoot growth and turf quality with increased salinity. Manilagrass cv. Matrella (FC13521) ( Zoysia matrella (L.) Merr.), seashore paspalum (Hawaii selection) ( Paspalum vaginatum Swartz), and St. Augustinegrass (Hawaii selection) ( Stenotaphrum secundatum Walt.) were tolerant, shoot growth being reduced 50% at ≈400 m m salinity. Bermudagrass cv. Tifway ( Cynodon dactylon × C. transvaalensis Burtt-Davey) was intermediate in tolerance, shoot growth being reduced 50% at ≈270 m m salinity. Japanese lawngrass cv. Korean common ( Zoysia japonica Steud) was salt-sensitive, while centipedegrass (common) ( Eremochloa ophiuroides (Munro) Hack.) was very salt-sensitive, with total shoot mortality occurring at ≈230 and 170 m m salinity, respectively. Salinity tolerance was associated with exclusion of Na + and Cl - from shoots, a process aided by leaf salt glands in manilagrass and bermudagrass. Shoot Na + and Cl - levels were high at low (100 to 200 m m ) salinity in centipedegrass and Japanese lawngrass resulting in leaf burn and shoot die-back. Levels of glycinebetaine and proline, proposed cytoplasmic compatible solutes, increased with increased salinity in the shoots of all grasses except centipedegrass, with tissue water levels reaching 107 and 96 m m at 400 m m salinity in bermudagrass and manilagrass, respectively. Glycinebetaine and proline may make a significant contribution to cytoplasmic osmotic adjustment under salinity in all grasses except centipedegrass.
Grain refinement control in gas-shielded arc welding of aluminum tubing (1974)

The objectives of this study were to evaluate the binding behavior of Cu(II) and Eu(III) with water extractable organic matter (WEOM) in soil, and assess the competitive effect of the cations. Excitation-emission matrix (EEM) fluorescence spectrometry was used in combination with parallel factor analysis (PARAFAC) to obtain four WEOM components: fulvic-like, humic-like, microbial degraded humic-like, and protein-like substances. Fluorescence titration experiments were performed to obtain the binding parameters of PARAFAC-derived components with Cu(II) and Eu(III). The conditional complexation stability constants (logKM) of Cu(II) with the four components ranged from 5.49 to 5.94, and the Eu(III) logKM values were between 5.26 to 5.81. The component-specific binding parameters obtained from competitive binding experiments revealed that Cu(II) and Eu(III) competed for the same binding sites on the WEOM components. These results would help understand the molecular binding mechanisms of Cu(II) and Eu(III) with WEOM in soil environment.
The Interaction of a Floating Body with Vertical Walls (1988)

The wave interaction of a floating sphere with two vertical walls is discussed. Graphs of the frequency domain and equivalent time domain added mass, damping, Froude-Krylov and diffraction forces, and Response Amplitude Operators (RAO) are presented. The linearized frequency domain velocity potentials are constructed by a multipole expansion used in conjunction with the method of images. The discrete Fourier Transform converts frequency data to Impulse Response Functions (IRF). Peaks in the IRF envelope curve indicate the effect of outlying images, which for practical cases are separated in time. A technique for identifying wall reflection effects from measurements in a finite basin is described.