gebhart/patrepeval huggingface dataset:
Ring-slippage chemistry of transition metal cyclopentadienyl and indenyl complexes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing-slippage chemistry of transition metal cyclopentadienyl and indenyl complexesJoseph M. O'Connor and Charles P. CaseyCite this: Chem. Rev. 1987, 87, 2, 307–318Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/cr00078a002https://doi.org/10.1021/cr00078a002research-articleACS PublicationsRequest reuse permissionsArticle Views2781Altmetric-Citations454LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Three-dimensional analysis of the vascular system in the rat spinal cord with scanning electron microscopy of vascular corrosion casts. Part 2: Acute spinal cord injury. (1993)

The purpose of this study was to investigate the vascular mechanisms involved in the pathophysiology of acute spinal cord injury. Vascular corrosion casts of traumatized rat spinal cords at C7-T1 were inspected by scanning electron microscopy. Nineteen rats were subjected to a 51g acute clip compression at C8-T1 and then underwent transcardial perfusion with polyester resin at 15 minutes, 4 hours, or 24 hours after injury. The injured spinal cord appeared almost avascular at the compression site, although the large vessels on the surface of the spinal cord were all intact. The sulcal arteries at the injury site frequently showed constriction, and the impressions of endothelial nuclei were more slender and less distinct in the constricted arterial casts. Extravasation of the injected resin at the injury site was observed most frequently in the 15-minute group. Poorly filled distal branches of the sulcal arteries were seen at the injury site in every group. Indeed, it was concluded that the disruption and occlusion of the sulcal arteries and their branches accounted for a considerable amount of the posttraumatic ischemia of the cord. Occlusion of the sulcal arteries in the anterior median sulcus at the injury site was more frequently observed in the 24-hour group than in earlier groups. This observation suggests that there was a progressive circulatory disturbance of the damaged sulcal arteries at the injury site. The 4- and 24-hour groups showed avascular areas extending longitudinally from the injury site in the posterior columns, probably the result of hemorrhage and venous obstruction.
Neuropsychological, Psychiatric, and Cerebral Blood Flow Findings in Vascular Dementia and Alzheimer’s Disease (1996)

Patients with IVD showed a relatively more severe dysfunction of the frontal lobes as demonstrated by single-photon emission CT and expressed in specific psychiatric and neuropsychological changes than AD patients matched for age, sex, and severity of dementia.
Networked device capability and content media format matching scheme for multimedia access (2007)

This paper presents a scheme to dynamically match capabilities of content sinks and media formats of items supplied by content sources to improve interoperability among a wide range of networked CE devices. The scheme proposes the use of transcoders located in external networks (e.g. Internet) when a match is not found locally. Here "media format" refers to the combination of content encoding format and packaging or transport method used to make available the content item on the network. Existing capability matching methods rely on standard repositories agreed a priori such as MIME (multipurpose Internet mail extensions) media types, and DLNA (Digital Living Network Alliance) media format profiles. The proposed scheme based on external transcoders enables support of profiles based on newly invented formats or new combinations of existing formats and packaging or transport methods. This extensible approach makes possible rendering of content items available in media profiles unknown to the renderer. Our capability matching scheme improves media interoperability when compared with existing methods.
Cholesterol oxidation products in whole milk powder: analytical, nutritional, processing and toxicological studies (1997)

The possibility that consumption of aged whole milk powders containing significant levels of cholesterol oxides may be detrimental to health has stimulated extensive research. In this study, the effects of feeding regimen and processing technology on the oxidative stability of lipids and cholesterol in whole milk powders were evaluated. Animal feeding regimen had a significant effect (p < 0.05) on the levels of total protein, true protein, casein protein and whey protein in standardised milk over the experimental period. Levels of peroxides, thiobarbituric acid reactive substances and cholesterol oxidation products were used as indices of lipid oxidation occurring in whole milk powders. Lipid and cholesterol oxidation increased significantly (p < 0.01) after 12 months storage, the predominant oxysterols being 7-ketocholesterol, cholesterol-a-and (3-epoxides, 25-hydroxycholesterol and cholestanetriol. A positive correlation was found between the levels of thiobarbituric acid reactive substances and cholesterol oxidation products. Significant decreases in lipid oxidation were observed as a result of high pre-heat treatment of milk prior to processing (p < 0.001), vacuum packing of powders in laminated foil bags prior to storage (p < 0.05), and storing powders at reduced temperatures (15° C) (p < 0.05). Levels of free sulphydryl groups, which possess antioxidant activity in whole milk powders, increased significantly (p < 0.05) as a result of a grass plus concentrate-fed diet and the application of high pre-heat treatment of milk. The toxicity of these oxysterols was evaluted using primary cultures of porcine ovarian granulosa cells. The activities of catalase and superoxide dismutase, two antioxidant defense enzymes, were increased significantly (p < 0.01) following 24 hour exposure to 2.5 (iM concentrations of both cholestanetriol and 25- hydroxycholesterol. Levels of thiobarbituric acid reactive substances remained unchanged under these conditions. Administration of a-tocopherol to the culture medium significantly (p < 0.01) improved cell viability and restored catalase and superoxide dismutase activities to control levels. These studies suggest that oxysterols, at levels found in whole milk powders were non cytotoxic.
Haemolytic-uraemic syndrome complicating shigella dystentery in south Indian children. (1978)

Shigella dysentery caused 65% of all cases of acute renal failure (ARF) seen in children treated at the Christian Medical College Hospital, Vellore, during the 33 months ending September 1977. In the 40 children with ARF secondary to shigella dysentery, haematological findings suggested that they were suffering from the haemolytic-uraemic syndrome, and glomerular hypercellularity and fibrin deposition were present in all 12 patients whose renal histology could be studied. Peritoneal dialysis was the main element of treatment: 43% of children who underwent dialysis improved, compared with only 25% of those who did not undergo dialysis. The haemolytic-uraemic syndrome precipitated by bacillary dystentery is therefore the most important cause of ARF in children aged under 5 years in Tamil Nadu and the adjoining area of Andhra Pradesh.
Drug development to overcome resistance to EGFR inhibitors in lung and colorectal cancer (2011)

Epidermal growth factor receptor (EGFR) is a validated target in different human malignancies. EGFR tyrosine kinase inhibitors (TKIs) are known to contribute considerably to the extension of progression-free survival in EGFR-mutant non-small cell lung cancer and monoclonal antibodies (mAbs) targeting EGFR have also improved the efficacy outcomes in KRAS wild-type colorectal cancer. Nevertheless, a significant percentage of lung and colorectal cancer patients do not respond to anti-EGFR agents and secondary resistance after initial benefit is a challenging reality faced by clinicians. Extensive preclinical work on the potential mechanisms of resistance to EGFR inhibitors in different disease settings has guided the development of second-generation irreversible EGFR TKIs, more efficient anti-EGFR mAbs, and combination strategies with agents targeting other receptors and downstream effectors. In order to elucidate the role of the multiple therapeutic strategies under investigation to overcome EGFR inhibitors-resistance, rational drug development based on stringent preclinical data, biomarker validation and proper selection of patients in the ongoing clinical trials are of paramount importance. Preliminary results of clinical trials evaluating these approaches will be discussed in this manuscript, with emphasis on TKIs in lung cancer and mAbs in advanced colorectal cancer.
Radiochemical studies on contact lens soilation. I. Lens uptake of 14C‐lysozyme from simple and complex artificial tear solutions (1997)

A systematic study has been made of the uptake of lysozyme by various contact lens materials. Lens uptake of 14C-methylated lysozyme was assessed using simple to complex artificial tear solutions. The data reflect prominent uptake by Group IV (ionic, high-water-content) hydrogel lenses, consistent with the literature. This includes protein on the lens surface and in the lens matrix, the former being estimated at about 33% of the total deposit for the DuraSoft 3 lenses used. Uptake appears to be contingent upon the nature of the lens material, the composition of the deposit model used, and the duration of lens exposure to the artificial tear solution. © 1997 John Wiley & Sons, Inc.
Using Historical Information of Patients for Prior Authorization Learning (2019)

Prior authorization (or preauthorization) is a control mechanism used by a Health Maintenance Organization (HMO) to minimize the waste of resources by analyzing each medical request. One of the strategies used to optimize this task is the use of a system that automates part of this process through a machine learning approach. This paper presents an approach that introduces the historical request from beneficiaries to the learning process in preauthorization in order to improve performance of the classification. For this, different approaches to data pre-processing and classification were tested. In the proposed methodology three types of historical representation were tested: binary, term frequency (TF) and term frequency-inverse document frequency (TF-IDF). For each of these representations, feature selection and transformation algorithms were applied: consistency subset eval, wrapper subset eval and Kernel PCA (KPCA). In the classification were tested three classic algorithms of machine learning: Random Forest (RF), Support Vector Machine (SVM) and K-neareast neighbors (KNN). In order to evaluate the results obtained, we used the Precision, Recall and Kappa index metrics for each of the problem classes. A comparison based on the hypothesis test Z is also performed to evaluate the improvement that the addition of the historical information has brought about to the learning process. The results point to a significant improvement in the performance of classifiers, where the representation in term frequency combined with KPCA brought the most positive results.
Large-Scale MIMO Versus Network MIMO for Multicell Interference Mitigation (2014)

This paper compares two important downlink multicell interference mitigation techniques, namely, large-scale (LS) multiple-input multiple-output (MIMO) and network MIMO. We consider a cooperative wireless cellular system operating in time-division duplex (TDD) mode, wherein each cooperating cluster includes <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$B$</tex></formula> base-stations (BSs), each equipped with multiple antennas and scheduling <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$K$</tex></formula> single-antenna users. In an LS-MIMO system, each BS employs <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$BM$</tex> </formula> antennas not only to serve its scheduled users, but also to null out interference caused to the other users within the cooperating cluster using zero-forcing (ZF) beamforming. In a network MIMO system, each BS is equipped with only <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$M$</tex> </formula> antennas, but interference cancellation is realized by data and channel state information exchange over the backhaul links and joint downlink transmission using ZF beamforming. Both systems are able to completely eliminate intra-cluster interference and to provide the same number of spatial degrees of freedom per user. Assuming the uplink-downlink channel reciprocity provided by TDD, both systems are subject to identical channel acquisition overhead during the uplink pilot transmission stage. Further, the available sum power at each cluster is fixed and assumed to be equally distributed across the downlink beams in both systems. Building upon the channel distribution functions and using tools from stochastic ordering, this paper shows, however, that from a performance point of view, users experience better quality of service, averaged over small-scale fading, under an LS-MIMO system than a network MIMO system. Numerical simulations for a multicell network reveal that this conclusion also holds true with regularized ZF beamforming scheme. Hence, given the likely lower cost of adding excess number of antennas at each BS, LS-MIMO could be the preferred route toward interference mitigation in cellular networks .
A multi-scale convolutional neural network for phenotyping high-content cellular images (2017)

Supplementary data are available at Bioinformatics online.
Production of a Platelet Aggregation Inhibitor, Salmosin, by High Cell Density Fermentation of Recombinant Escherichia coli (2011)

Optimal conditions for a high cell density fermentation were investigated in a recombinant Escherichia coli producing salmosin, a platelet aggregation inhibitor. The optimized carbon and nitrogen sources were glycerol 10 g/l, yeast extract 30 g/l, and bacto-tryptone 10 g/l, yielding the dry cell weight (DCW) of 10.61 g/l in a 500 ml flask culture. The late-stage induction with 1% L-arabinose in a 5 l jar fermentor showed the highest DCW of 65.70 g/l after 27 h of the fed-batch fermentation. Around 2,200 mg/l of the protein was expressed as an inclusion body that was then refolded to obtain the active salmosin of 96 mg/l. We also confirmed the inhibitory activity against platelet aggregation of the active salmosin from the high cell density fermentation.
A novel predictive global motion estimation for video coding (2003)

Global motion compensation improves the coding efficiency by reducing the transmitted motion vectors and reconstructs a more accurate prediction image for texture coding. Predictors are widely in local motion estimation and it is well proven that the use of predictors can speed up the local motion estimation process. In this paper, we propose a novel predictive global motion estimation algorithm, which combines the prediction idea and global motion estimation. The proposed algorithm first examines sum absolute difference of a set of candidate predictors and uses the predictor: with minimum SAD as the initial search center of N-dimensional diamond search to find the final global motion parameter. Although the PSNR of proposed algorithm is slightly lower than MPEG-4 VM GME, the speed of the proposed algorithm is significantly faster.
Stimulation of Keratinocyte Migration by Growth Factors (1992)

Migration of keratinocytes from the wound edge is thought to be one of the critical features of reepithelialization. A quantitative migration assay was carried out using normal human keratinocytes. Keratinocytes, seeded on 12 well plates, were grown in serum free, keratinocyte growth medium (KGM, Curabo Co) with 0.08 mM Ca2+. The medium was switched from KGM to keratinocyte basal medium (KBM) 6 h prior to the wounding. Half of the plate's confluent monolayer of keratinocytes was removed with razor blade, and the remaining keratinocytes were incubated in KBM for 16 hrs in the presence of indicated growth factors. After incubation, the cells were fixed and counted at 100 magnification. Migration was quantitated by counting the number of cells in ten successive 125-microns zones. Transforming growth factor alpha (TGF-alpha), acidic and basic fibroblast growth factor (aFGF, bFGF), keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), and insulin-like growth factor-I (IGF-I) stimulated the migration of keratinocytes, while TGF-beta suppressed it.
Researchers Lack Data on Trends In UV Radiation at Earth's Surface (1993)

RETURN TO ISSUEPREVNewsNEXTResearchers Lack Data on Trends In UV Radiation at Earth's SurfaceExisting measurements are few and ambiguous; U.S. agencies working to set up networks of monitoring stationsPAMELA S. ZURERView Author Information C&EN WashingtonCite this: Chem. Eng. News 1993, 71, 30, 35–37Publication Date (Print):July 26, 1993Publication History Published online11 November 2010Published inissue 26 July 1993https://pubs.acs.org/doi/10.1021/cen-v071n030.p035https://doi.org/10.1021/cen-v071n030.p035newsACS PublicationsCopyright © 1993 AMERICAN CHEMICAL SOCIETYArticle Views8Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Electromagnetic radiation Get e-Alerts
A Comparative Study on the Characteristics of Cancer Patients and Cancer Survivors (2018)

Purpose: The purpose of the study was to identify and compare the characteristics of cancer patients and cancer survivors. Methods: This study used data from the Korea National and Health Nutrition Examination Survey (2010~2015), conducted by the Center for Disease Control and Prevention. This study included 455 cancer patients and 567 cancer survivors. The data were analyzed by descriptive statistics, t-tests, and χ². Results: Cancer survivors were less compliant compared to cancer patients in drinking frequency (χ²=13.12, p ≤.001), drinking volume (χ²=13.35, p=.001) and cancer screening tests (χ²=4.79, p=.029). Cancer patients showed higher body weight change compared to cancer survivors (χ²=7.37, p=.025). There was no difference in quality of life (QoL) between the two groups (t=1.38, p=.169). Conclusion: This study indicates that cancer survivors have poor living habits and no improvement in QoL compared to cancer patients. Oncology nurses should pay attention to cancer survivors compliance of living habits to prevent secondary cancer and to improve their QoL.
Assessing Theoretical Risk and Benefit suggested by Genetic Association Studies of CCR5: Experience in a Drug Development Programme for Maraviroc (2007)

The proliferation of published gene association studies of the CCR5delta32 mutation is of relevance to drug development of a CCR5 antagonist for HIV, in highlighting potential safety concerns. We conducted an initial review of all non-HIV gene association studies of CCR5-delta32, followed by detailed meta-analyses in the three disease areas most commonly reported. Our review indicated no consistent evidence of increased risk of susceptibility to hepatitis C virus infection or multiple sclerosis among individuals with CCR5-delta32 mutation, and suggested treatment with a CCR5 inhibitor is unlikely to have related adverse effects. There was, however, evidence to suggest rheumatoid arthritis as a potential therapeutic target for a CCR5 antagonist. Clinical evidence would be required to confirm these findings.
HEAT TRANSFER MEASUREMENTS FOR FLOW OF NANOFLUIDS IN MICROCHANNELS USING TEMPERATURE NANO-SENSORS (2012)

A premiere free-access and peer-reviewed frontier journal site, serving the needs of the thermal-fluids community. See the latest research or submit an article. Quickly share your research with the global thermal-fluids community, for increased citations and impact at no cost.
Super‐resolution methods in MRI: Can they improve the trade‐off between resolution, signal‐to‐noise ratio, and acquisition time? (2012)

Improving the resolution in magnetic resonance imaging comes at the cost of either lower signal-to-noise ratio, longer acquisition time or both. This study investigates whether so-called super-resolution reconstruction methods can increase the resolution in the slice selection direction and, as such, are a viable alternative to direct high-resolution acquisition in terms of the signal-to-noise ratio and acquisition time trade-offs. The performance of six super-resolution reconstruction methods and direct high-resolution acquisitions was compared with respect to these trade-offs. The methods are based on iterative back-projection, algebraic reconstruction, and regularized least squares. The algorithms were applied to low-resolution data sets within which the images were rotated relative to each other. Quantitative experiments involved a computational phantom and a physical phantom containing structures of known dimensions. To visually validate the quantitative evaluations, qualitative experiments were performed, in which images of three different subjects (a phantom, an ex vivo rat knee, and a postmortem mouse) were acquired with different magnetic resonance imaging scanners. The results show that super-resolution reconstruction can indeed improve the resolution, signal-to-noise ratio and acquisition time trade-offs compared with direct high-resolution acquisition.