gebhart/patrepeval huggingface dataset:
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis (2003)

We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of polo-like kinase 1 (Plk1). MKlp2 is a target for Plk1, and phosphorylated MKlp2 binds to the polo box domain of Plk1. Plk1 also binds directly to microtubules and targets to the central spindle via its polo box domain, and this interaction controls the activity of Plk1 toward MKlp2. An antibody to the neck region of MKlp2 that prevents phosphorylation of MKlp2 by Plk1 causes a cytokinesis defect when introduced into cells. We propose that phosphorylation of MKlp2 by Plk1 is necessary for the spatial restriction of Plk1 to the central spindle during anaphase and telophase, and the complex of these two proteins is required for cytokinesis.
MLlib: Machine Learning in Apache Spark (2015)

Apache Spark is a popular open-source platform for large-scale data processing that is well-suited for iterative machine learning tasks. In this paper we present MLlib, Spark's open-source distributed machine learning library. MLlib provides efficient functionality for a wide range of learning settings and includes several underlying statistical, optimization, and linear algebra primitives. Shipped with Spark, MLlib supports several languages and provides a high-level API that leverages Spark's rich ecosystem to simplify the development of end-to-end machine learning pipelines. MLlib has experienced a rapid growth due to its vibrant open-source community of over 140 contributors, and includes extensive documentation to support further growth and to let users quickly get up to speed.
Characterization of a novel human pre-B leukemia cell line. (1981)

The derivation of a new human pre-B cell line from the leukocytes of a girl in the leukemic phase of lymphoblastic lymphoma is reported. Cells of this line, termed SMS-SB, synthesized mu but not light chains. These mu-chains were found only in the cytoplasm and were not secreted. SMS-SB cells bore HLA-DR determinants. They did not express the common ALL antigen or terminal deoxynucleotidyl transferase and, therefore, differed from previously described human pre-B leukemia cell lines. SMS-SB cells resembled certain Abelson leukemia virus-transformed mouse bone marrow cells. Except for the lack of formed mouse bone marrow cells. Except for the lack of mu secretion, the phenotype of SMS-SB cells was the same as the major subpopulation of marrow pre-B cells.
DIALKYLAMINOBENZONITRILES AS FLUORESCENCE POLARITY PROBES FOR AQUEOUS SOLUTIONS OF CYCLODEXTRINS (1984)

Abstract— The dual fluorescence of 4‐(N, N‐dimethylamino)benzonitrile and 4‐(N, N‐diethylamino)‐benzonitrile (DMABN and DEABN, respectively), has been studied in aqueous solutions of cyclodextrins. Fluorescence parameters (peak maximum, lifetime, and relative intensity) have been measured and are found to be consistent with the formation of complexes of probe and cyclodextrin. Enhanced emission of the twisted internal charge transfer state (TICT) fluorescence is observed in cyclodextrin, with the greatest effect for the DMABN/α‐cyclodextrin system. Our results promote further understanding of both the photophysical behavior of DMABN and the complexation of probe with cyclodextrin. The use of dialkylaminobenzonitriles as polarity probes is discussed.
A new synthesis of 10‐arylisoalloxazines (10‐arylflavins) (1979)

Abstract The condensation of 6‐arylamino‐ and 6‐alkylaminouracils with nitrosobenzenes in a mixture of acetic anhydride and acetic acid gave the corresponding 10‐aryl‐ and 10‐alkylisoalloxazines (flavins).
Quantum Theory of a Basic Light-Matter Interaction (1972)

Quantum field-theoretical methods are applied to the problem of determining how the exciton-lattice interaction affects the dispersion of an electromagnetic field associated with the exciton-radiation interaction. An exact solution for the retarded Green's function of the radiation field is calculated for a quantum model consisting of three interacting boson fields-photon, exciton, and phonon. The classical Green's function of a damped-harmonic-oscillator model of a dielectric is shown to be a special case of this quantum Green's function. Two sets of dispersion relations are derived; one set has well-defined energy, the other has well-defined momentum. Results of the theory clearly suggest that the exciton-lattice interaction is capable of literally damping out the "polariton" effects associated with the exciton-radiation interaction in the field solutions with well-defined energy. A Poynting theorem based on the classical model is also derived which includes effects of both spatial dispersion and damping.
Accurate alignment of functional EPI data to anatomical MRI using a physics-based distortion model (2000)

Mapping of functional magnetic resonance imaging (fMRI) to conventional anatomical MRI is a valuable step in the interpretation of fMRI activations. One of the main limits on the accuracy of this alignment arises from differences in the geometric distortion induced by magnetic field inhomogeneity. This paper describes an approach to the registration of echo planar image (EPI) data to conventional anatomical images which takes into account this difference in geometric distortion. We make use of an additional spin echo EPI image and use the known signal conservation in spin echo distortion to derive a specialized multimodality nonrigid registration algorithm. We also examine a plausible modification using log-intensity evaluation of the criterion to provide increased sensitivity in areas of low EPI signal. A phantom-based imaging experiment is used to evaluate the behavior of the different criteria, comparing nonrigid displacement estimates to those provided by a imagnetic field mapping acquisition. The algorithm is then applied to a range of nine brain imaging studies illustrating global and local improvement in the anatomical alignment and localization of fMRI activations.
Management of anorexia-cachexia associated with cancer and HIV infection. (1991)

The cachexia associated with cancer and AIDS appears to result from a number of processes, most of which impair caloric intake. Although past attempts to reverse anorexia-cachexia have generally been disappointing, several promising new pharmacologic approaches are currently being evaluated, including megestrol acetate, hydrazine sulfate, metoclopramide, and dronabinol.
NO<sub>x</sub> Emission Control in Oxygen-Rich Exhaust Through Selective Catalytic Reduction by Hydrocarbon (1993)

Selective catalytic reduction of nitrogen monoxide by hydrocarbon in the presence of oxygen and sulphur dioxide has very recently been found on copper ion-exchanged ZSM-5 zeolite (Cu-ZSM-5). The reaction proceeds even in the oxidizing atmosphere at temperatures as low as 573 K. Addition of oxygen to the reactant stream is necessary to achieve the selective reduction of nitrogen monoxide. The increment of concentration of hydrocarbon increased the conversion into nitrogen and expanded the active temperature region. After summarizing the new findings on Cu-ZSM-5, the present review introduces catalytic activities of various metal-ion exchanged zeolites and metal-loaded aluminas. Based on the temperature dependence of each catalyst and the change of conversion of nitrogen monoxide into nitrogen with space velocity, Cu-ZSM-5 is suggested as one of the strong candidates for catalysts applicable to lean-burn gasoline and diesel engines, though several problems such as durability to water and overheating remain to be solved.
Stable isotope ratio analysis at trace concentrations using degenerate four-wave mixing with a circularly polarized pulsed probe beam (1991)

Stable isotope analysis based on vectorial optical-phase conjugation by resonant degenerate four-wave mixing (D4WM) is reported by using a D4WM method with vertically polarized pump beams and a circularly polarized probe beam. Since the polarization of the signal beam is different from that of the pump beams, the background radiation is suppressed more effectively. Excellent sensitivity, high spectral resolution, and efficient optical detection make this an effective and unusually convenient nonlinear spectrometric method for the analysis of trace amounts of stable isotopes. Using an excimer-pumped pulsed dye laser, the fine structures of lithium are examined. A detection limit of 2.5 ng/mL lithium is observed while a Doppler-free resolution is maintained by using transient "coherent-grating" based D4WM spectroscopy.
The Theory of Klystron Oscillations (1939)

The principles governing the oscillations in a klystron may be divided into four groups: (1) those of space resonance within each rhumbatron, previously discussed by Hansen; (2) the equations of coupled circuits, with modifications appropriate to space-resonant systems; (3) the kinematics and dynamics of cathode-ray bunching, previously discussed by the author; (4) the constraint on phase relations between the rhumbatrons introduced by the cathode-ray bunches. It is shown here that (4) makes the oscillations assume forms very different from those familiar in free oscillations. These forms are described by general equations and then these equations are applied to three specific problems: maximizing the power output from an oscillator, minimizing the power input for an ideal regenerative amplifier, and finding how stable the frequency is against changes in cathode potential.
Sample injection port for high-pressure chromatography (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSample injection port for high-pressure chromatographyBrian. Pearce and W. L. ThomasCite this: Anal. Chem. 1972, 44, 6, 1107–1109Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://doi.org/10.1021/ac60314a042Request reuse permissionsArticle Views47Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (368 KB) Get e-Alertsclose Get e-Alerts
Reprogramming the Genetic Code (2012)

Incorporating unnatural amino acids into proteins presents challenges in expanding the genetic code.
Essentials of anticoagulation in hemodialysis (2007)

Numerous acquired hemostatic abnormalities have been identified in renal insufficiency. Hemodialysis procedures add to these disturbances as they repetitively imply turbulent blood flow, high shear stress, and contact of blood to artificial surfaces. This nonphysiological environment leads to activation of platelets, leukocytes, and the coagulation cascade, resulting in fouling of the membrane and ultimately in clotting of fibers and the whole hemodialyzer. Anticoagulation in hemodialysis is targeted to prevent this activation of coagulation during the procedure. Most agents inhibit the plasmatic coagulation cascade. Still commonly used is unfractionated heparin, followed by low-molecular-weight heparin preparations with distinct advantages. Immune-mediated heparin-induced thrombocytopenia constitutes a potentially life-threatening complication of heparin therapy requiring immediate switch to nonheparin alternative anticoagulants. Danaparoid, lepirudin, and argatroban are currently being used for alternative anticoagulation, all of which possess both advantages and limitations. In the past, empirical strategies reducing or avoiding heparin were applied for patients at bleeding risk, whereas nowadays regional citrate anticoagulation is increasingly used to prevent bleeding by allowing procedures without any systemic anticoagulation. Avoidance of clotting within the whole hemodialyzer circuit is not granted. Specific knowledge of the mechanisms of coagulation, the targets of the anticoagulants in use, and their respective characteristics constitutes the basis for individualized anticoagulation aimed at achieving full patency of the circuit throughout the procedure. Patency of the circuit is an important prerequisite for optimal hemodialysis quality.
Spoken English <i>in the</i> Gold Coast (1954)

Spoken English in the Gold Coast Get access PETER STREVENS PETER STREVENS Search for other works by this author on: Oxford Academic Google Scholar ELT Journal, Volume VIII, Issue 3, SPRING 1954, Pages 81–89, https://doi.org/10.1093/elt/VIII.3.81 Published: 01 March 1954
Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport (1997)

A sensitive immunohistochemical technique was used, along with highly specific affinity-purified antibodies to brain-derived neurotrophic factor (BDNF), to generate a detailed mapping of BDNF immunoreactivity (BDNF-ir) throughout the adult rat CNS. A parallel analysis of sites of BDNF synthesis was performed with in situ hybridization techniques using a cRNA probe to the exon encoding mature rat BDNF protein. These combined data revealed (1) groups of cell bodies containing diffuse BDNF-ir throughout the CNS that were strongly correlated with fields of cells containing BDNF mRNA; (2) varying degrees of BDNF-ir outside of cell bodies, in what appeared to be fibers and/or terminals; and (3) many regions containing extremely heavy BDNF-immunoreactive fiber/terminal labeling that lacked BDNF mRNA (e.g., medial habenula, central nucleus of the amygdala, bed nucleus of stria terminalis, lateral septum, and spinal cord). The latter observation suggested that in these regions BDNF was derived from anterograde axonal transport by afferent systems. In the two cases in which this hypothesis was tested by the elimination of select afferents, BDNF immunostaining was completely eliminated. These data, along with the observation that BDNF-ir was rarely found within dendrites or fibers en passage, suggest that BDNF protein produced in adult CNS neurons is polarized primarily along axonal processes and is preferentially stored in terminals within the innervation target.
Simple and versatile synthesis of copper and silver N-heterocyclic carbene complexes in water or organic solvents (2010)

A novel synthetic route leading to N-heterocyclic carbene copper complexes has been developed by using air-stable and commercially available copper(I) oxide and imidazolium salts starting materials.
DT-CNN: Dilated and Transposed Convolution Neural Network Accelerator for Real-Time Image Segmentation on Mobile Devices (2019)

A convolution neural network (CNN) accelerator is proposed for real-time image segmentation on mobile devices. The proposed CNN processor cuts down the redundant zero computations in dilated and transposed convolution for higher throughput. As a result, the overall computations of the image segmentation are reduced by 86.6% and the proposed CNN processor boosts up the throughput 6.7×. Moreover, the proposed processor utilizes RoI (Region of Interest) based image segmentation algorithm to reduce the overall computational requirement significantly. Although RoI based image segmentation degrades the image segmentation accuracy, the proposed dilation rate adjustment compensates for the accuracy degradation and maintains the accuracy of the full-size image segmentation. Finally, the proposed CNN processor is simulated in 65 nm CMOS technology, and it occupies 6.8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The proposed processor consumes 196 mW and shows 211 frames-per-second (fps) at the image segmentation for human body parts.
Advanced ABAP programming for SAP (1999)

From the Publisher:
With this book, the thousands of new ABAP/4 programmers will learn the most advanced techniques required to develop custom applications using SAP's R/3 system and the Internet. Real-life examples are presented to support every topic.
Fluorinated Quinazolones. Part V : Synthesis of Some Fluorinated Quinazolone Derivatives (1978)

Department of Chemistry, University of Rajasthan, Jaipur (India) <em>Manuscript received 73 December 1977, revised 10 May 1978, acrepted 23 May 1978</em> Synthesis of fluorinated 2, 3-dihydrothiazolo-(2, 3-b)-quinazolin-5-ones(I), 4-aryl­thiazolido-[3, 2-a]-quinazolin-1, 5(4H)-diones(IV) and 5H-2,3-diphenyitetrazepino-[1,2,4,5] [3, 2-b]-9-fluoroquinazolin-11-one has been presented and the mechanism of trans­formation of 6-fluoro-2-ethylthio-3-phenyl-4(3H)-quinazolone(V) into 3-amino-6-tluoro­2-hydrazino-4(3H)-quinazolone(VI) has been discussed.
On Designated Verifier Signature Schemes. (2010)

Designated verifier signature schemes allow a signer to convince only the designated verifier that a signed message is authentic. We define attack models on the unforgeability property of such schemes and analyze relationships among the models. We show that the no-message model, where an adversary is given only public keys, is equivalent to the model, where an adversary has also oracle access to the verification algorithm. We also show a separation between the no-message model and the chosen-message model, where an adversary has access to the signing algorithm. Furthermore, we present a modification of the Yang-Liao designated verifier signature scheme and prove its security. The security of the modified scheme is based on the computational Diffie-Hellman problem, while the original scheme requires strong Diffie-Hellman assumption.
Unique Identification for Monitoring of COVID-19 Using the Internet of Things (IoT) (2020)

In this paper, a unique identification system is proposed for monitoring the most recently discovered coronavirus (COVID-19). This infectious disease took a large number of lives in a different country. This proposed system can monitor the users from COVID-19 by using the Internet of Things(IoT). A system is designed where thermal scanning of the human body by a sensor and daily the record of the same user is being stored in the database. For identification of each user, there is a development of QR code which is a one-time generation process. If a person having a normal GSM phone then there will be a unique identification number is generated and shared with the operator who registers them to the system so that they can also take benefits. If any person or user having some symptoms and while scanning via a thermal scanner if their body temperature will be 100F or more then a pop-up message will generate and via the audio system will ask him or she is suffering from fever, shore throat, and difficulty in breathing. If a person having all these symptoms then our system will send a message to their mobile for consulting the doctor or for a test. Our proposed system is untouched and operates automatically.
Design of adiabatic selective pulses using optimal control theory (1996)

Optimal control theory has been applied in the past for the design of RF pulses for selective excitation. This was the outcome of having established the controllability of the MR spin system for the selective excitation problem. "Minimum distance" was the main formulation used for the solution. Because of their robust behavior in the presence of inhomogeneous RF fields, adiabatic pulses play an important role in spin inversion and excitation. In this study, we present a method for incorporating adiabaticity into the optimal control problem by enhancing the cost functional with an appropriate term. Two different types of adiabatic terms are proposed. Furthermore, two methods are used to solve the optimal control problem, namely the Hamiltonian approach and the solution by mathematical programming. Design examples include both a frequency selective pulse for performing fat suppression by inversion and a regular inversion pulse. It is shown that, in the course of optimization, the pulse designer can trade-off slice resolution against pulse adiabaticity.
Kallikreins on Steroids: Structure, Function, and Hormonal Regulation of Prostate-Specific Antigen and the Extended Kallikrein Locus (2010)

The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-specific expression profiles and putative proteolytic functions. The kallikrein family is also emerging as a rich source of disease biomarkers with KLK3, commonly known as prostate-specific antigen, being the current serum biomarker for prostate cancer. The kallikrein locus is also notable because it is extraordinarily responsive to steroids and other hormones. Indeed, at least 14 functional hormone response elements have been identified in the kallikrein locus. A more comprehensive understanding of the transcriptional regulation of kallikreins may help the field make more informed hypotheses about the physiological functions of kallikreins and their effectiveness as biomarkers. In this review, we describe the organization of the kallikrein locus and the structure of kallikrein genes and proteins. We also focus on the transcriptional regulation of kallikreins by androgens, progestins, glucocorticoids, mineralocorticoids, estrogens, and other hormones in animal models and human prostate, breast, and reproductive tract tissues. The interaction of the androgen receptor with androgen response elements in the promoter and enhancer of KLK2 and KLK3 is also summarized in detail. There is evidence that all kallikreins are regulated by multiple nuclear receptors. Yet, apart from KLK2 and KLK3, it is not clear whether all kallikreins are direct transcriptional targets. Therefore, we argue that gaining more detailed information about the mechanisms that regulate kallikrein expression should be a priority of future studies and that the kallikrein locus will continue to be an important model in the era of genome-wide analyses.
Extreme edge-friendly indices of complete bipartite graphs (2016)

Let G=(V,E)G=(V,E) be a simple graph‎. ‎An edge labeling f:E→{0,1}f:E→{0,1} induces a vertex labeling f+:V→Z2f+:V→Z2 defined by f+(v)≡∑uv∈Ef(uv)(mod2)f+(v)≡∑uv∈Ef(uv)(mod2) for each v∈Vv∈V‎, ‎where Z2={0,1}Z2={0,1} is the additive group of order 2‎. ‎For i∈{0,1}i∈{0,1}‎, ‎let‎ ‎ef(i)=|f−1(i)|ef(i)=|f−1(i)| and vf(i)=|(f+)−1(i)|vf(i)=|(f+)−1(i)|‎. ‎A labeling ff is called edge-friendly if‎ ‎|ef(1)−ef(0)|≤1|ef(1)−ef(0)|≤1‎. ‎If(G)=vf(1)−vf(0)If(G)=vf(1)−vf(0) is called the edge-friendly index of GG under an edge-friendly labeling ff‎. ‎Extreme values of edge-friendly index of complete bipartite graphs will be determined‎.
Traffic trends analysis using neural networks (1997)

An application of time series prediction, to traffic forecasting in ATM networks, using neural nets is described. One key issue, the number of data points needed to be included in the input representation to the net is discussed from a theoretical point of view, and the results are applied in the model under discussion. Experimental results are discussed and analysed.