gebhart/patrepeval huggingface dataset:
Characteristics of<i>Neo Red Cells</i>, their Function and Safety:<i>In Vivo</i>Studies (1994)

A new type of artificial oxygen carriers, the Neo Red Cells (NRCs) have been developed and investigated for oxygen transporting efficiency and safety in experimental animals. Stroma free hemoglobin from outdated human red blood cells together with inositol hexaphosphate as an allosteric effector under sterile, pyrogen free condition were encapsulated in liposomes and then were coated with polyethylene glycol bond to hydrogenated soy phosphatidylethanolamine as a surface modifier to prevent aggregation of NRCs in plasma. The efficiency of the NRCs in tissue oxygenation was studied in rabbits which were made severely anemic by drawing 85% of their blood and immediately replacing it with NRC solution. The animals, all recovered to pre-anemic conditions within 6-8 hr and lived normally until being sacrificed, 6 months after the exchange transfusion. The circulation half-life and tissue distribution of NRCs were studied using radiolabeled NRCs. Within the circulation, the half-life of NRCs was 21 hr and extravascularly, they were distributed mainly in and metabolized by the reticuloendothelial system within 7 days. Our observations suggest that the NRCs prepared and investigated in this study are efficient oxygen carriers without causing serious adverse reactions and can be prepared free from pathogenic micro-organisms by special filtration technique before encapsulation of Hb. Currently, experiments are ongoing to control auto-oxidation of oxyHb to metHb which is higher in NRCs than in native red cells at physiological conditions.
Energy distribution of boron ions during plasma immersion ion implantation (1992)

The ion energy distribution during plasma immersion ion implantation (PIII) has been computed including charge transfer collisions in a dynamic sheath. The boron ion energy distribution has been derived experimentally from sheet resistance and SIMS measurements. The experimental results are consistent with theoretical predictions. Both the experimental and theoretical results indicate that during the PIII doping experiments boron ions have a relatively wide energy distribution and that many of the ions have low energies because of collisions in the sheath.
Abstract WMP75: Functional Role of Hemojuvelin in Acute Ischemic Stroke (2018)

Background and Purpose: Hemojuvelin (HJV)-hepcidin axis has been shown an important pathophysiological mechanism in acute liver and kidney injuries, but little is known about the role of HJV in acute stroke. Our aim was to establish the temporal expression and function of HJV during acute ischemic stroke (AIS). Methods: C57BL/6J mice receiving 1-hour middle cerebral artery occlusion (MCAO) and primary cortical neurons subjected to oxygen and glucose deprivation (OGD) were performed to determine the expression profile of HJV after AIS. Infarct sizes and behavior scores at 72 hours post MCAO on HJV knockout (129S-Hfe2tm1Nca/J) and wild type (129S) mice were compared to determine the role of HJV. In addition, patients with AIS were recruited and plasma samples were collected for the measurement of HJV. Results: The expression of HJV protein in mice brain was noted early at 3 hours after MCAO and increased significantly at 72 hours after MCAO, along with the appearance of its downstream protein- hepcidin at the same time point. In cultured cortical neurons, the expression of HJV protein also increased remarkably at 24-48 hours after 3 hours OGD stimulation. Importantly, HJV knockout mice had significantly less infarct size and expression of cleaved caspase-3 protein compared with wild type mice at 72 hours post MCAO. In human subjects, HJV expression can be seen in autopsy brain tissues from stroke patients with mortality outcome. In addition, among 112 AIS patients, plasma level of HJV within 48 hours after stroke was an independent poor prognostic predictor of functional outcome at 3 months post-stroke (odds ratio: 1.780; 95% confidence intervals: 1.032-3.073; p =0.038). Conclusions: HJV- hepcidin axis is existing in mice brain and participating in the mechanisms of post stroke neuronal injury. Clinically, plasma HJV may be a potential outcome indicator in patients with AIS.
Magnetic properties of BaM∕Pd–Pt double-layered thin film deposited at various substrate temperatures (2005)

Crystallographic and magnetic properties of barium ferrite (BaM) thin films deposited onto Pt, Pd, and an alloy of Pd–Pt underlayers by sputtering at different substrate temperatures (Ts) from 400to600°C have been studied. It is found that the coercivity values in the perpendicular direction (Hcperp) of the BaM∕Pd–Pt films are higher than those of the BaM films deposited on Pd and Pt underlayers. C-axis orientation of BaM∕Pd–Pt film can be achieved at very low Ts of 450°C with a Hcperp of 2.1kOe for 30-nm BaM.
Low-molecular-weight chiral cation exchangers: Novel chiral stationary phases and their application for enantioseparation of chiral bases by nonaqueous capillary electrochromatography (2002)

Cation exchange type chiral stationary phases (CSPs) based on 3,5-dichlorobenzoyl amino acid and amino phosphonic acid derivatives as chiral selectors (SOs) and silica as chromatographic support were developed and applied to enantiomer separations of chiral bases by nonaqueous capillary electrochromatography (NA-CEC). As a rationale for efficient CSP development we adopted the combined use of the "reciprocity principle of chiral recognition" and nonaqueous ion-pair CE as screening assay. Thus, (S)-atenolol was employed as chiral counter-ion added to the BGE in CE and a series of N-derivatized amino acids and amino phosphonic acids were screened to derive reciprocally information on their chiral recognition abilities for atenolol enantiomers. Two SO candidates, namely N-(3,5-dichlorobenzoyl)-O-allyl-tyrosine and N-(4-allyloxy-3,5-dichlorobenzoyl)-1-amino-3-methylbutane phosphonic acid that have been identified as potential SOs in the CE screening were, after immobilization on thiol-modified silica, evaluated in cation-exchange NA-CEC. The strong chiral cation exchanger with the free phosphonic acid group exhibited enhanced enantioselectivity compared to the weak chiral cation exchanger with the carboxylic acid group. A wide variety of chiral bases could be successfully resolved on the strong chiral cation exchanger with alpha-values up to 2.2 and efficiencies up to 375000 m-1 including beta-blockers and other amino alcohols, local anesthetics like etidocaine, antimalarial agents like mefloquine, Tröger's base, phenothiazines like promethazine, and antihistaminics. The influence of several experimental parameters (electrolyte concentration, acid-base ratio and acetonitrile-methanol ratio) was evaluated.
Distributed Bragg Reflector Lasers (1999)

Abstract The sections in this article are Dbr and Laser Basics The Bragg Period Edge‐Emitting Single Frequency Lasers Vcsel Conclusion
Treatment outcomes for patients with glioblastoma multiforme and a low Karnofsky Performance Scale score on presentation to a tertiary care institution (2011)

Patients with a KPS score ≤ 50 appear to have increased survival and functional status following tumor resection and radiation. The extent of benefit from concomitant chemotherapy is unclear. Future studies may benefit from reporting that utilizes a prognostic classification system such as the RTOG RPA class, which has been shown to be effective at separating outcomes even in patients with low performance status. Patients with GBMs and low KPS scores need to be evaluated in prospective studies to identify the extent to which different therapies improve outcomes.
Disordered Regions in Semiconductors Bombarded by Fast Neutrons (1959)

The width and depth of the potential wells surrounding disordered regions in neutron irradiated n-type germanium and extrinsic silicon are estimated. Numerical examples of well dimensions for a wide range of sample characteristics are presented. Some effects of disordered regions, e.g., (a) scattering of conduction electrons, (b) absorption of holes, and (c) polarizability, are discussed.
Towards a Hippocratic log file architecture (2004)

The World Wide Web (WWW) is fast becoming the central location for goods, services and information. The very factors that make the Internet such a powerful medium, combine to make the Internet a treasure trove of personal information regarding individual Web users. Users' movements and information are logged as they navigate the Web, often without their knowledge and definitely without their explicit consent. This has lead to internet users voicing concerns over the loss and violation of privacy. Inspired by the Hippocratic Oath, Agrawal et al. [2002] introduced the concept of Hippocratic database systems. These systems are responsible for the privacy of data they manage, and must comply with ten defined principles. In a previous paper, the authors investigated the feasibility of applying the ten principles of Hippocratic databases to the management of log files. The focus of this paper is to expand on the originally proposed Hippocratic log file architecture by introducing a layered view of the architecture. In examining this layered view, the major processes that would be involved in the implementation of Hippocratic log files will be discussed.
An Aloha protocol for multihop mobile wireless networks (2006)

An Aloha-type access control mechanism for large mobile, multihop, wireless networks is defined and analyzed. This access scheme is designed for the multihop context, where it is important to find a compromise between the spatial density of communications and the range of each transmission. More precisely, the analysis aims at optimizing the product of the number of simultaneously successful transmissions per unit of space (spatial reuse) by the average range of each transmission. The optimization is obtained via an averaging over all Poisson configurations for the location of interfering mobiles, where an exact evaluation of signal over noise ratio is possible. The main mathematical tools stem from stochastic geometry and are spatial versions of the so-called additive and max shot noise processes. The resulting medium access control (MAC) protocol exhibits some interesting properties. First, it can be implemented in a decentralized way provided some local geographic information is available to the mobiles. In addition, its transport capacity is proportional to the square root of the density of mobiles which is the upper bound of Gupta and Kumar. Finally, this protocol is self-adapting to the node density and it does not require prior knowledge of this density.
SGP4 Orbit Determination (2008)

In 2006, an updated version of SGP4 was presented for general use. The propagation routine relies on Two-Line Element (TLE) set data provided by the U.S. Government for several decades. Many independent organizations have access to observations, or ephemerides developed with other programs. Because the TLE is a compact means to obtain modestly accurate and fast calculations, it is desirable to have an orbit determination package that is compatible with the aforementioned code. This paper presents the code, test cases, and discussion of computer code to produce TLE data from an externally derived ephemeris. Initial code is also developed for processing raw observations.
Polysilicon TFT circuit design and performance (1992)

Both n- and p-channel polysilicon TFTs can be fabricated, allowing CMOS circuit techniques to be used. However, TFT characteristics are poor in comparison to conventional single-crystal MOSFETs, and relatively coarse design rules must be used to be compatible with processing on large-area glass plates. The authors examine these issues and describe the performance of a range of digital and analog circuit elements built using polysilicon TFTs. Digital circuit speeds in excess of 20 MHz are reported, along with operational amplifiers with over 80 dB of gain and more than 1-MHz unity-gain frequency. Several polysilicon TFT switched-capacitor circuits are also reported and shown to have adequate linearity, output swing, and settling time to form integrated data line drivers on an active-matrix liquid crystal display.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The density, electrical conductivity, freezing point, and viscosity of mixtures of trifluoromethanesulfonic acid and water (1978)

Density, viscosity, specific conductivity, and freezing point measurements over the whole composition range of water–trifluoromethanesulfonic acid mixtures are reported. A maximum in viscosity and minimum in specific conductivity are observed at the composition corresponding to the monohydrate, H 3 O + SO 3 CF 3 − , and a maximum deviation from the ideal density is found at the composition corresponding to H 5 O 2 + SO 3 CF 3 − . The freezing point curve gives evidence for four hydrates with 1:1, 2:1, 4:1, and 6:1 water/trifluoromethanesulfonic acid mole ratios. An incongruent melting hydrate, probably 2:1 acid to water mole ratio is also indicated.
Consolidation of patients awaiting placement: a two-year review. (1994)

Toronto's Wellesley Hospital retrospectively reviewed the effectiveness of consolidating long-stay patients within one environment where they were cared for by an integrated interdisciplinary team. The study found that this approach resulted in cost-effective care, improved patient outcome, improved bed utilization and prevention of unnecessary institutionalization. The model is universal and easily reproducible.
Asymmetric Hydrocyanation of Benzaldehydes Catalyzed by (5<i>R</i>)-5-(4-Imidazolylmethyl)-2,4-imidazolidinedione (1991)

Abstract The catalytic activity of (5R)-5-(4-imidazolylmethyl)-2,4-imidazolidinedione (3) was examined in the asymmetric hydrocyanation of 3-phenoxybenzaldehyde (1a) to (S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile ((S)-2a), an important alcohol moiety of optically active pyrethroid insecticides. Among the catalysts, 3-benzyl derivative (3d) exhibited moderate enantioselectivities for 1a and other benzaldehydes.
Evaluation of Peroxides as Cross-linking Agents for High Density Polyethylene (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvaluation of Peroxides as Cross-linking Agents for High Density PolyethyleneR. S. Gregorian and R. A. BaffordCite this: Ind. Eng. Chem. Prod. Res. Dev. 1964, 3, 4, 267–269Publication Date (Print):December 1, 1964Publication History Published online1 May 2002Published inissue 1 December 1964https://doi.org/10.1021/i360012a004Request reuse permissionsArticle Views173Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (288 KB) Get e-Alerts
Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus (1997)

Leptin is a protein product of the obese (ob) gene, which is secreted by adipocytes and functions as a satiety factor to regulate food intake. The expression of the leptin receptor in several hypothalamic nuclei suggests that multiple neuronal subtypes are targets for leptin's action. Products of the proopiomelanocortin (POMC) gene are known to affect feeding behavior, and POMC neurons share a similar distribution with leptin receptor mRNA in the arcuate nucleus. We used double label in situ hybridization and computerized image analysis to test the hypothesis that POMC neurons coexpress the leptin receptor. Quantitative analysis confirmed that POMC neurons in the hypothalamus express leptin receptor mRNA. Based on this observation, we infer that POMC neurons and the products of the POMC gene may be part of the signaling pathway mediating leptin's action on feeding and perhaps other physiological functions.
Continuous Size-Separation of Airborne Particles in a Microchannel for Aerosol Monitoring (2011)

The real-time monitoring of aerosols is important for protecting human health and the environment. The small size of microchannels and their potential for integration with sensing technologies suggest them as a promising tool for the next generation of aerosol sensors. To that end, we present a novel microfluidics-based system for the size-separation of aerosols using the centrifugal force exerted on each particle as it travels around a curve. We demonstrate with simulations and experiments the separation by size of mixtures of aerosolized microspheres with diameters ranging from 0.2-3.2 μm. With bidisperse particle sizes in a single-outlet channel, a separation efficiency is defined to quantify how much of each of the two sizes of particles are located in distinct regions of the channel; the separation of mixtures at up to 80% separation efficiency is demonstrated. Particles are also separated into two or three outlets, each containing a different distribution of particles by size. Both experimental particle position and separation efficiency results match well with the simulations.
Low-cost hardware profiling of run-time and energy in FPGA embedded processors (2011)

This paper introduces a low-overhead hardware profiling architecture, called LEAP, that attains real-time cycle and energy profiles of an FPGA-based soft processor. A novel technique is used to associate profiling data with specific functions in a way that is area- and power-efficient. Results show that relative to a previously-published hardware profiler, our design uses up to 18× less area and 8.6× less energy. LEAP is designed to be extensible for a variety of profiling tasks, three of which are investigated in this paper. We also demonstrate the utility of LEAP in the context of hardware/software co-design of processor/accelerator FPGA-based systems.
High-resolution low-power CMOS D/A converter (1989)

A very low-power, high-resolution, medium-speed D/A converter is described. The converter was realized using a standard analog CMOS technology. It achieved 15-bit monotonicity and less than 0.07-percent overall linearity at a clock frequency of 100 kHz, without requiring any trimming or calibration. The measured SNR was 85 dB, the power dissipation was less than 10 mW, and the distortion for a sinusoidal output was less than 0.04 percent. The D/A converter is intended for battery-powered speech and music synthesis applications where high dynamic range, low power, and low cost are all important.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Herstellung einiger styrolderivate mit ungesättigten substituenten in <i>p</i>‐stellung (1962)

Abstract p ‐Butenylstyrol, p ‐äthinylstyrol und p ‐Vinylphenylallen wurden hergestellt. Ebenso wurde das p ‐Allylstyrol nach einem neuen Verfahren in guter Ausbeute erhalten. Die Styrolderivate wurden homopolymerisiert und mit Styrol copolymerisiert.
Lithium Chloride Promotes Apoptosis in Human Leukemia NB4 Cells by Inhibiting Glycogen Synthase Kinase-3 Beta (2015)

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). With the application of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), APL becomes one of best prognosis of leukemia. However, ATRA and ATO are not effective against all APLs. Therefore, a new strategy for APL treatment is necessary. Here, we investigated whether lithium chloride (LiCl), a drug used for the treatment of mental illness, could promote apoptosis in human leukemia NB4 cells. We observed that treatment with LiCl significantly accelerated apoptosis in NB4 cells and led to cell cycle arrest at G2/M phase. Moreover, LiCl significantly increased the level of Ser9-phosphorylated glycogen synthase kinase 3β(p-GSK-3β), and decreased the level of Akt1 protein in a dose-dependent manner. In addition, LiCl inhibition of c-Myc also enhanced cell death with a concomitant increase in β-catnin. Taken together, these findings demonstrated that LiCl promoted apoptosis in NB4 cells through the Akt signaling pathway and that G2/M phase arrest was induced by increase of p-GSK-3β(S9).
Smaller, Softer, Safer, Smarter Robots (2013)

Advances in robotics aim to extend physician capabilities.
Direct resolution of enantiomeric diols by capillary gas chromatography on a chiral polysiloxane derived from (R,R)-tartramide (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect resolution of enantiomeric diols by capillary gas chromatography on a chiral polysiloxane derived from (R,R)-tartramideKouji. Nakamura, Takafumi. Saeki, Masaaki. Matsuo, Shoji. Hara, and Yasuo. DobashiCite this: Anal. Chem. 1990, 62, 5, 539–541Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/ac00204a022https://doi.org/10.1021/ac00204a022research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts