gebhart/patrepeval huggingface dataset:
The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2. (1992)

An RNA-binding protein gene (rbp1) from Drosophila melanogaster, encoding an RNA recognition motif and an Arg-Ser rich (RS) domain, has been characterized. The predicted amino acid sequence of rbp1 is similar to those of the human splicing factor ASF/SF2, the Drosophila nuclear phosphoprotein SRp55, and the Drosophila puff-associated protein B52. Northern and immunohistochemical analyses showed that rbp1 is expressed at all stages in all tissues and that the RBP1 protein is localized to the nucleus. Consistent with a role in mRNA metabolism, indirect immunofluorescence reveals that the RBP1 protein colocalizes with RNA polymerase II on larval salivary gland polytene chromosomes. RBP1 protein made in Escherichia coli was tested for splicing activity using human cell extracts in which ASF has been shown previously both to activate splicing and to affect the choice of splice sites in alternatively spliced pre-mRNAs. In these assays, RBP1 protein, like ASF, is capable of both activating splicing and switching splice site selection. However, in each case, clear differences in the behavior of the two proteins were detected, suggesting that they have related but not identical functions. The general nuclear expression pattern, colocalization on chromosomes with RNA polymerase II, the similarity to ASF/SF2, SRp55, and B52, along with the effect on alternative splicing shown in vitro, suggest that rbp1 is involved in the processing of precursor mRNAs.
BASES DAS ESCOLAS EUROPÉIA E NORTE-AMERICANA, PERANTE A CULTURA CONTÁBIL E A PROPOSTA NEOPATRIMONIALISTA (2002)

Como entender a matéria contábil, o método que se emprega para estudá-la, o respeito às tradições históricas como conquistas já feitas, as grandes finalidades desse conhecimento, em suma, como possuir uma visão realista e verdadeira sobre os fenômenos da riqueza individualizada é o que caracteriza uma "escola científica de Contabilidade". Diversos desses núcleos se formaram e ainda se formam, não só no setor contábil, mas, em todas as ciências, sempre em torno de lideranças, quer de pensadores, quer de grupos interessados em manipular idéias. Algumas escolas, todavia, basearam-se apenas no consenso de grupos e se ataram a um raciocínio pragmático. Por serem diferentes as concepções e os efeitos do tratamento que se tem dado à Contabilidade, as principais distinções de entendimento encontram-se, na atualidade, entre as escolas norte-americanas, pragmáticas e as européias, científicas. No Brasil a corrente científica do neopatrimonialismo oferece novas propostas em suas bases, mas, mantendo a fidelidade com as raízes latinas do conhecimento contábil.
Energy based spectrum sensing using wavelet transform for fading channels (2012)

In this paper, we present a spectrum sensing algorithm based on energy level at different frequency bands using wavelet transform for Cognitive Radio (CR) applications. Existence of a primary user's signal may be detected by searching for wavelet coefficients having energy higher than a threshold value corresponding to communication channel noise energy. The wavelet based algorithm is tested with Binary Phase Shift Keying (BPSK) modulated signals under two channel models introducing fading channel affect and additive white Gaussian noise with different Signal to Noise Ratios (SNRs). In order to evaluate accuracy of the algorithm, probability of detection is evaluated.
Research on User Identity Authentication Technology for Virtual Laboratory System (2015)

The users need identity authentication before entering virtual lab and that needs to respectively set up users information management mechanism, this paper analyzes and designs uniform identity authentication and concentrating information management. Then, we analyze functional requirement of virtual laboratory platform, discusses uniform identity authentication module of virtual laboratory in detail and interprets system structure, business process, interface and database design of uniform identity authentication of virtual laboratory platform. Based on analyzing current technology, this paper proposes virtual laboratory platform-oriented designing improvement program so as to reduce users' portal obstacles between virtual laboratories and improve user experience.
XL-DNase-seq: improved footprinting of dynamic transcription factors (2019)

XL-DNase-seq may help extract novel gene regulatory circuits involving previously undetectable TFs. The DNase-seq and ATAC-seq data generated in our systematic comparison of various cross-linking conditions also represent an unprecedented-scale resource derived from activated mouse macrophage-like cells which share many features of inflammatory macrophages.
Large-diameter waveguide Bragg grating components and their application in downhole oil and gas sensing (2004)

A new class of Bragg grating components based on large diameter cylindrical waveguides has been commercially released. Unique properties of the waveguide including grating fabrication, low loss splicing to optical fibers, and specialized machining for optimization in sensor applications are reported. The waveguide structure enables packaging of Bragg gratings that overcomes attachment, mechanical creep, and hermeticity problems commonly associated with fiber Bragg gratings. This enables exceptionally robust Bragg grating sensor transducers well suited for the high temperature, corrosive downhole environment of oil and gas. Sensor transducers have been demonstrated showing no measurable drift or error after over 4-year aging tests at 150°C. More than 50 pressure/temperature installations have been successfully completed and are operational, delivering real-time data cumulatively over 500,000 operation hours. These systems integrate a range of support components specific to in-well oil and gas applications, such as downhole cables, interconnects, and platform instruments. This optical sensing platform, coupled with other optical techniques, has been extended beyond optical pressure/temperature measurements to distributed temperature measurements, multiphase flow, and in-well seismic sensing. These systems have been successfully deployed in multi-zonal, multi-parameter system architectures. This sensing technology is integrated with in-well controls, data acquisition and interpretation, and reservoir modeling. This systems approach is required to close the value loop of intelligent completions in oil and gas production.
High-Efficiency Fuel Cell Power Conditioning System With Input Current Ripple Reduction (2008)

A high-efficiency fuel cell power conditioning system with input current ripple reduction is proposed. The proposed system consists of a high-efficiency high-step-up current-fed resonant push-pull converter and a full-bridge inverter. The converter conserves inherent advantages of a conventional current-fed push-pull converter such as low input-current stress and high voltage conversion ratio. Also, a voltage-doubler rectifier is employed in order to remove the reverse-recovery problem of the output rectifying diodes and provide much higher voltage conversion ratio. The current ripple reduction control without an external component is suggested. Therefore, the proposed system operates in a wide input-voltage range with a high efficiency. By using a current-ripple reduction control, the input current ripple is furthermore reduced. A 1.5-kW prototype is implemented with input-voltage range from 30 to 70 V. Experimental results show that minimum efficiency at full load is about 92.5% and that ripple current is less than 2% of the rated input current.
Genetic Analysis as a Tool to Investigate the Molecular Mechanisms Underlying Seed Development in Maize (2005)

• Background In angiosperms the seed is the outcome of double fertilization, a process leading to the formation of the embryo and the endosperm. The development of the two seed compartments goes through three main phases: polarization, differentiation of the main tissues and organs and maturation.
Contextual Query Expansion for Image Retrieval (2014)

In this paper, we study the problem of image retrieval by introducing contextual query expansion to address the shortcomings of bag-of-words based frameworks: semantic gap of visual word quantization, and the efficiency and storage loss due to query expansion. Our method is built on common visual patterns (CVPs), which are the distinctive visual structures between two images and have rich contextual information. With CVPs, two contextual query expansions on visual word-level and image-level are explored, respectively. For visual word-level expansion, we find contextual synonymous visual words (CSVWs) and expand a word in the query image with its CSVWs to boost retrieval accuracy. CSVWs are the words that appear in the same CVPs and have same contextual meaning, i.e. similar spatial layout and geometric transformations. For image-level expansion, the database images that have the same CVPs are organized by linked list and the images that have the same CVPs as the query image, but not included in the results are automatically expanded. The main computation of these two expansions is carried out offline, and they can be integrated into the inverted file and efficiently applied to all images in the dataset. Experiments conducted on three reference datasets and a dataset of one million images demonstrate the effectiveness and efficiency of our method.
A Multilevel Method for Image Registration (2006)

In this paper we introduce a new framework for image registration. Our formulation is based on consistent discretization of the optimization problem coupled with a multigrid solution of the linear system which evolves in a Gauss--Newton iteration. We show that our discretization is h-elliptic independent of parameter choice, and therefore a simple multigrid implementation can be used. To overcome potential large nonlinearities and to further speed up computation, we use a multilevel continuation technique. We demonstrate the efficiency of our method on a realistic highly nonlinear registration problem.
Impregnated cathode coated with tungsten thin film containing Sc2O3 (1987)

An impregnated cathode of a novel structure is proposed, fabricated, and evaluated. A thin tungsten film 100–400 nm in thickness containing various amounts of Sc2O3 is coated on a standard impregnated cathode composed of a porous tungsten body in which electron emissive materials are impregnated. The electron emission property measured with a diode configuration is found to be dependent on Sc2O3 content and surface atom distribution. Surface atom distribution is depicted by means of Auger electron spectroscopy. For high electron emission enhancement it is necessary for Sc2O3 content to be 2.5–6.5 wt. % and for a layer of the order of a monolayer in thickness composed of Ba, Sc, and O to develop on the cathode surface.
Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes. (1983)

Activated pneumococcal polysaccharide (PPS)-specific human B lymphocytes have been purified and examined in vitro. They are large cells that are refractory to further activation by antigen, anti-Ig, or Staphylococcus aureus Cowan strain I, but they respond directly by proliferation to B cell growth factors. In addition, they express the isotype pattern of activated cells and a surface marker of activated lymphocytes called 4F2. Finally, they contain a subset of cells that spontaneously secrete PPS-specific antibody.
Green energy based inductive Self-Healing highways of the future (2016)

This paper deals with a green energy highway in the Netherlands. Here, the development of electric mobility and self- driving cars is introduced. The ideas of wireless power integration with green energy technologies - solar and wind is considered. In case of wind energy, conventional turbines and bladeless vortex are considered as options. Solaroads along the emergency lanes are also investigated. A Dutch highway A12 is considered as a case study and sizing of these energy sources for electric mobility is considered. A grid power demand profile is considered and number of EVs that can be charged hourly is calculated. A preliminary investigation of the combination of IPT and Self-Healing roads is considered in this study.
Inhibition of clathrin-coated vesicle acidification by duramycin. (1984)

Clathrin-coated vesicles contain a proton translocating ATPase which operates in parallel with a chloride transporter (Xie, X.-S., Stone, D.K., and Racker, E. (1983) J. Biol. Chem. 258, 14834-14838). The polypeptide antibiotic, duramycin, has a dual inhibitory effect on clathrin-coated vesicle acidification. Low amounts of duramycin (5 micrograms/100 micrograms of protein) inhibit by 50% the proton translocation facilitated by chloride translocation. Under these conditions duramycin inhibits also 36Cl uptake when driven by either the electrogenic proton pump or by inward directed K+ movement in the presence of valinomycin. Higher amounts of duramycin (20 micrograms/100 micrograms of protein) are needed to inhibit by 50% the proton pump itself, as evidenced by reduced proton translocation facilitated by an outward potassium movement in the presence of valinomycin. In addition, the amount of duramycin needed to inhibit the proton pump corresponded well with the amount needed to inhibit the ouabain-insensitive, N-ethylmaleimide-sensitive ATPase activity of clathrin-coated vesicles.
Design of dual-mode SIW cavity filters (2007)

For designing the dual-mode substrate-integrated waveguide (SIW) cavity filters, new methods of generating intra-cavity couplings and transmission zeros are presented. Two adjustment techniques for refining the frequency responses are also presented. Compared with a conventional four-pole quadruplet filter, a proposed four-pole dual-mode coupled-cavity filter can provide two additional transmission zeros, which enhance the side-band rejection. A 24-GHz SIW cavity filter with a symmetrical frequency response was designed using the new methods and fabricated using LTCC multilayer process.
Trigeminocardiac reflex during surgery in the cerebellopontine angle (1999)

The authors' results show the possibility of occurrence of a TCR during manipulation of the central part of the trigeminal nerve when performing surgery in the CPA.
DFT-spread OFDM for optical communications (2010)

We propose DFT-spread OFDM (DFT-S-OFDM) to mitigate fiber nonlinearity in long-haul transmission systems. For 1000-km standard-single-mode-fiber transmission at 420-Gb/s, 32-band DFT-S-OFDM outperforms conventional coherent optical-OFDM (CO-OFDM) and coherent single-carrier by 1.1 and 0.8 dB, respectively.
Organ dose calculation in CT based on scout image data and automatic image registration (2012)

The automated image processing method to registrate individual chest and abdominal CT scout radiograph with the reference scout radiograph is feasible. It can be used to determine the individual scan range coordinates in z-direction to calculate the organ dose values. The presented method could be utilized in automatic organ dose calculation in CT for radiation exposure tracking of the patients.
Spatial Quantitation of Drugs in tissues using Liquid Extraction Surface Analysis Mass Spectrometry Imaging (2016)

Liquid extraction surface analysis mass spectrometry imaging (LESA-MSI) has been shown to be an effective tissue profiling and imaging technique, producing robust and reliable qualitative distribution images of an analyte or analytes in tissue sections. Here, we expand the use of LESA-MSI beyond qualitative analysis to a quantitative analytical technique by employing a mimetic tissue model previously shown to be applicable for MALDI-MSI quantitation. Liver homogenate was used to generate a viable and molecularly relevant control matrix for spiked drug standards which can be frozen, sectioned and subsequently analyzed for the generation of calibration curves to quantify unknown tissue section samples. The effects of extraction solvent composition, tissue thickness and solvent/tissue contact time were explored prior to any quantitative studies in order to optimize the LESA-MSI method across several different chemical entities. The use of a internal standard to normalize regional differences in ionization response across tissue sections was also investigated. Data are presented comparing quantitative results generated by LESA-MSI to LC-MS/MS. Subsequent analysis of adjacent tissue sections using DESI-MSI is also reported.
Uncovering the mystery of ferroelectricity in zero dimensional nanoparticles (2018)

It is generally accepted that chemically synthesized nanoparticles lose their ferroelectricity (spontaneous polarization) as the particles become smaller. In contrast, ball-milled ferroelectric nanoparticles have an enhanced ferroelectric response at remarkably small sizes (≤10 nm). Although prior theory suggests that surface stress influences ferroelectricity, the source of such a stress and how it physically influences ferroelectricity in zero-dimensional nanoparticles has remained a mystery. In this paper, we demonstrate that the top-down approach of wet ball-milling not only results in fragmented materials on the nanoscale, but it also is responsible for a mechanochemical synthesis of metal carboxylates forming at the nanoparticles' surface. We prove that the presence of such a compound with a particular type of binding mode chemisorbed at the nanoparticles' surface is responsible for producing surface stress. This surface stress results in a stabilization and dramatic enhancement of the spontaneous polarization, which is 5 times greater than that of the bulk material and 650 times greater than what is measured in materials fabricated using standard chemical synthesis techniques. The results of this study have further led to the development of a new process that produces ferroelectric nanoparticles (≤10 nm) with uniform shape and size using a combination of wet chemistry and mechanochemical synthesis.
Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle (2015)

We evaluate strategies to maximize the field of view (FOV) of in vivo retinal OCT imaging of human eyes. Three imaging modes are tested: Single volume imaging with 85° FOV as well as with 100° and stitching of five 60° images to a 100° mosaic (measured from the nodal point). We employ a MHz-OCT system based on a 1060nm Fourier domain mode locked (FDML) laser with a depth scan rate of 1.68MHz. The high speed is essential for dense isotropic sampling of the large areas. Challenges caused by the wide FOV are discussed and solutions to most issues are presented. Detailed information on the design and characterization of our sample arm optics is given. We investigate the origin of an angle dependent signal fall-off which we observe towards larger imaging angles. It is present in our 85° and 100° single volume images, but not in the mosaic. Our results suggest that 100° FOV OCT is possible with current swept source OCT technology.
Synthesis of α‐Alkynyl‐β,β,β‐trifluoroalanine Derivatives by Sonogashira Cross‐Coupling Reaction (2010)

Abstract An efficient route to new α‐CF 3 ‐α‐amino acid derivatives bearing an arylalkynyl moiety at the α‐carbon atom has been developed. The method is based on palladium‐catalyzed cross‐coupling of the corresponding α‐propargyl (ethynyl) α‐amino esters with aryl halides to afford the amino acid derivatives with an internal triple bond that is suitable for further modifications.
Coupled resonator optical waveguides (2002)

Properties of the recently introduced family of coupled resonator optical waveguides (CROWs) are reviewed, particularly with reference to CROWs designed as planar waveguides in two-dimensional photonic crystal slabs to enhance nonlinear interactions and develop novel all-optical information processing devices. Topics covered include: pulse propagation both in the nondispersive approximation and to all orders of dispersion, and the coupled mode theory of nonlinear optics with pulses in CROWs and its applications to second-harmonic generation and wave coupling via field-induced refractive-index gratings. We also review recent experimental progress in the fabrication and characterization of CROWs, and applications of the CROW concept to fiber gratings and microwave waveguides.
Analysis of the Effects of<i>N</i>-Substituents on Some Aspects of the Aromaticity of Imidazoles and Pyrazoles (2011)

The influence of the N-substituent on the aromaticity of azoles is a subject that has not yet been addressed in detail, in contrast to the good understanding of the corresponding C-substitution. In the present work, we analyze the aromaticities of a series of 1,2- and 1,3-azoles (pyrazoles and imidazoles, respectively) with the N-substituents NH(2), OH, Cl, SH, H, NO(2), CN, SO(2)F, SO(2)CF(3), and N(SO(2)CF(3))(2), which are also compared with the aromaticities of the corresponding substituted benzene series. The larger stabilitiy of the imidazole ring is due not to a higher aromaticity, but rather to the weakness of the N-N bond in the pyrazole series. The aromaticity of azoles was found to be significantly less robust to N-substitutions than that of their C-substituted benzene counterparts.
A framework for system level low power design space exploration (2017)

Power management is a key feature in many digital systems, mainly those powered by battery. Introducing a power management strategy in a system should save power consumption while its functional performance must remain within application-dependent constraints. Designing such systems could be very challenging since power management impacts performance and the functional activity impacts power. The most convenient design level to address such challenge is at system transactional level where hardware and software could be described inside a single simulation model. Unfortunately, there are very few proposals that address the description at transactional level of both a power intent and a clock intent which constitute the low power specification entry required by RTL low power design tools. In this paper, we propose a framework able to describe graphically a power/clock intent and to generate automatically the associated simulation code. Adding this code as an overlay to the SystemC-TLM code of design allows a joined power/performance analysis of the whole system. Our framework provides an efficient support for low power design space exploration.
Role of renin-angiotensin system in chronic renal hypertensive rats. (1979)

The role of renin-angiotensin system has been examined in the maintenance of hypertension in acute and chronic two-kidney (36 weeks) and chronic one-kidney (12 weeks) Goldblatt hypertensive rats using three inhibitors of this system. The inhibitors used were URI-73A, a synthetic analog of lysophosphatidylethanolamine, which inhibits renin both in vivo and in vitro, SQ14,225, a potent converting enzyme inhibitor, and [Sar1, Thr8] angiotensin II, an angiotensin II antagonist. When the inhibitors were administered in acute (high renin) hypertensive rats, they all lowered blood pressure significantly. However, in the chronic (low renin) hypertensive phase, both renin and converting enzyme inhibitors lowered blood pressure, whereas, Sar1, Thr8 failed to lower blood pressure. The renin inhibitor lowered plasma renin activity (PRA), and SQ14,225 and [Sar1, Thr8] Ang II increased PRA. Further studies on water and electrolyte balance with one-kidney model hypertensive and uninephrectomized control rats showed no change in plasma volume. However, there was increased 24-hour urinary output and increased sodium excretion. This study indicates that in chronic renal hypertensive rats, blood pressure reduction is possible by either renin on converting enzyme inhibitor, but not by angiotensin antagonists. Since volume did not change either during the development or reversal of hypertension, volume did not appear to play a major role in the maintenance of hypertension.