gebhart/patrepeval huggingface dataset:
부동산,금융,법제의 융합적 접근을 통한 상가권리금 보호강화 - 권리금의 법제화 및 신용보험을 중심으로 - (2015)

The amended Commercial Buildng Lease Protection Act what is called Protection Act for Goodwill was urgently executed from May 13. 2015. The other day, National Assembly passed a vote of the law at last after many twists and turns. The purpose of this historic amendments was to further protect lessees’ withdral of goodwill in commercial buildings. Until the legislation of goodwill, there has been no positive laws regarding goodwill of retail properties so that it was the custom between the parties to take goodwill when making a commercial leasing contract. This phenomenon reflects that giving-and receiving goodwill has been left outside the positive legal protection under the fair name of settlement of the parties themslves. However, it is pointed out that there exists several issues to be completed even though the revised Commercial Building Lease Protection Act which focusing the protection of goodwill of commercial properties means that the treat and protection of goodwill at last has been incorporated into the practical regal system. This study tries to review the contents of the legalization of the goodwill and to consider the method of practical protection for the collection of goodwill from the standpoint of interdisciplinary approaches including the related academic branches such as real estate, finance, and law. As a way of realistic method of goodwill protection, this study strongly suggest that the Credit Insurance for the goodwill in the retail properties should be introdued as soon as possible. Credit insurance, by nature, is a kind of payment protection insurance, purchased by consumers to insure payment of credit extended to the consumer. It is also a sort of credit derivative, financial instrument or technique desined to separate and then transfer the credit risk of an underlying loan. Accordingly, the introduction of credit insurance for the goodwill of commercial properties may of great use to protect the collection of lesee’s goodwill in the commercial lease trades.
Dynamic Service and Data Migration in the Clouds (2009)

Cloud computing is an emerging computation paradigm. To support successful cloud computing, service oriented architecture (SOA) should play a major role. Due to the nature of widely distributed service providers in clouds, the service performance could be impacted when the network traffic is congested. This can be a major barrier for tasks with real-time requirements. In clouds, this problem can be solved by migrating services to different platforms such that the communication cost can be minimized. In this paper, we consider the problem of service selection and migration in clouds. We develop a framework to facilitate service migration and design a cost model and the decision algorithm to determine the tradeoffs on service selection and migration.
PNA-Based Light-Up Probes for Real-Time Detection of Sequence-Specific PCR Products (2001)

The aim of this study was to introduce the use of a peptide nucleic acid (PNA)-thiazole orange conjugate for real-time monitoring of PCR. When the so-called light-up probes hybridize sequence-specifically to the PCR product, an increase in the fluorescent signal is obtained. It was found that the light-up probe can quantitatively measure the amount of DNA or intact bacterial cells in the reaction mixture, without interfering with the PCR amplification. A linear detection range of at least 4 log units was obtained without optimization of the system. The detection limit of this light-up assay per reaction mixture was 0.4 pg genomic Yersinia enterocolitica DNA.
A thermostat for molecular dynamics of complex fluids (2007)

A thermostat of the Nosé–Hoover type, based on relative velocities and a local definition of the temperature, is presented. The thermostat is momentum-conserving and Galilean-invariant, which should make it suitable for use in Dissipative Particle Dynamics (DPD) simulations, as well as nonequilibrium molecular dynamics simulations.
Influence of Various Pulp Properties on the Adhesion Between Tissue Paper and Yankee Cylinder Surface (2014)

The strength of the adhesion between the paper and the drying Yankee cylinder is of great importance with respect to the final properties of a tissue paper product. Therefore, the effects of a few potentially important pulp properties have been evaluated in laboratory experiments. Four highly different kraft pulps were used, and the adhesion strength was measured by means of the force required when scraping off a paper from a metal surface with a specifically designed knife mounted on a moving cart. The adhesion strength was observed to increase with increasing grammage and increasing degree of beating of the pulp. It was also found that pulps containing more fines, or with higher hemicellulose content, gave rise to higher adhesion strength.
The effect of air cooling on the radial temperature distribution of a single microwave hyperthermia antenna<i>in vivo</i> (1991)

Canine skeletal muscle was heated with a single microwave antenna within a brachytherapy catheter driven at 2000 MHz. The radial, steady-state temperature distribution was measured with and without air cooling of the antenna, as produced by room temperature air flowing in the catheter at 7.5 l/min. The axial temperature distribution was also measured with air cooling. In the antenna junction plane the area heated to a given temperature increased by a factor of four with air cooling when the same antenna temperature was enforced. With the same maximum temperature enforced, the area would increase by a factor of 2.5 with air cooling. The axial temperature distribution was not compromised by air cooling.
Blood–brain barrier breakdown and repair by Src after thrombin‐induced injury (2009)

Thrombin, via its protease-activated receptors, is postulated to activate Src kinase phosphorylation of molecules that acutely injure the BBB and produce edema. Thus, acute administration of Src antagonists blocks edema. In contrast, Src blockade for 2 to 6 days after thrombin injections is postulated to prevent resolution of edema and abnormal BBB permeability in part because Src kinase proto-oncogene members stimulate proliferation of newborn BMVECs and perivascular astrocytes in the neurovascular niche that repair the damaged BBB. Thus, Src kinases not only mediate acute BBB injury but also mediate chronic BBB repair after thrombin-induced injury.
Smartphone-based blood pressure monitoring for falls risk assessment: techniques and technologies (2017)

Smart patient monitoring systems have rapidly evolved during the past two decades and have the potential to improve current patient care and medical staffworkflow. With advanced sensors, sophisticated hardware and fast-growing wireless communication technologies, there are enormous opportunities for ubiquitous solutions in all areas of healthcare, especially patient monitoring. Current methods of non-invasive blood pressure measurement are based on inflation and deflation of a cuff with some effects on arteries where blood pressure is being measured. This approach is non-continuous, time delayed, and might cause patient discomfort. We aim to monitor and measure cuff-less and continuous blood pressure using a smartphone. Cuff-less approach enables continuous blood pressure monitoring capabilities and is particularly attractive as blood pressure is one of the most important factors to assess risk of falls in older adults. A smartphone application was developed to collect PhotoPlethysmoGram (PPG) waveform and electrocardiogram (ECG) in order to calculate pulse transit time (PTT). The user's systolic blood pressure is calculated using the PPT and precise optimisation model. The proposed application can be integrated with our developed falls risk assessment algorithm for inpatient older adults. This study proposes a novel approach of continuous blood pressure monitoring using cuff-less method that can be employed for prevention of inpatient falls using smartphone.
DEVELOPMENT OF REMOTE DISMANTLING SYSTEMS FOR DECOMMISSIONING OF NUCLEAR FACILITIES (2000)

number: 262 ABSTRACT In the Japan Power Demonstration Reactor decommissioning program remote handling technologies were developed that could be successfully applied to dismantling the core components and verified by successful work accomplishment. However, wider applications and intelligence to the work process were required to perform dismantling work efficiently. The dual arm systems and their control mechanism have been developed based on the lessons learned. Command packages for basic work procedures of dismantling components have been developed to control motions of the dual arm systems. The applicability of the command packages was then evaluated by controlling the dual arm systems. It was found that the command packages could be applied to controlling the dual arm systems in an efficient way.
Enhanced Gene Transfection in Macrophages by Histidine-Conjugated Mannosylated Cationic Liposomes (2009)

Targeted gene delivery to macrophages is important for the treatments of various immune diseases. Since macrophages express mannose receptors, development of efficient mannosylated non-viral carriers is an effective approach to macrophages-selective in vivo gene transfection. In this study, a pH-sensitive mannosylated cholesterol derivative, Man-His-C4-Chol, which possesses histidine (His) residues, containing lipoplexes (Man-His-lipoplexes) was characterized for transfection both in vitro and in vivo. In primary cultured macrophages, both Man-His-lipoplexes and mannosylated (Man)-lipoplexes showed significantly higher cellular uptake than bare-lipoplexes and there was no significant difference between Man-His-lipoplexes and Man-lipoplexes at 37 degrees C but the cellular uptake of these three lipoplexes was reduced at 4 degrees C. Similarly, the transfection efficacy of Man-His-lipoplexes showed significantly higher gene expression than bare-lipoplexes and Man-lipoplexes. After intraperitoneal administration to mice, Man-His-lipoplexes showed higher gene expression in peritoneally exuded cells (PECs) which contained macrophages than Man-lipoplexes and bare-lipoplexes at 3, 6, and 24 h. In addition, Man-His-lipoplexes showed higher gene expression than Gal-His-lipoplexes in PECs, suggesting that Man-His-lipoplexes are taken up by macrophages via mannose receptor-mediated endocytosis. These results suggest that Man-His-lipoplexes have superior transfection activity to Man-lipoplexes in macrophages.
Cloning of Size-Selected Human Immunoglobulin Heavy-Chain Rearrangements from Third Complementarity-Determining Region Fingerprint Profiles (1996)

Methods have been developed to rapidly visualize the size distribution of third complementarity-determining regions (CDR3) in immunoglobulin (Ig) and T-cell receptor (TCR) molecules. DNA fragments spanning the Ig or TCR CDR3 are generated by PCR using primers at fixed positions in the variable and constant segments. These fragments differ in length due to size variation of the CDR3s. Visualization of the amplification products in polyacrylamide gels as a "CDR3 fingerprint profile" is a rough measure for the complexity of the Ig and TCR antigen-binding specificities. We report an adaptation of this method for the analysis of human Ig heavy-chain genes that incorporates silver staining, which allows for the fine analysis of specific regions of the profiles. This is especially useful for the study of low-abundant transcripts.
Resistance to antitumor alkylating agents and cisplatin (1998)

Therapeutic resistance to the antitumor alkylating agents, as to any other type of molecular therapy, can be envisioned at three levels: (1) at the cellular level where biochemical alterations in the tumor cells confer resistance, (2) at the level of the tumor mass where physiological abnormalities and properties of the tumor confer resistance and (3) at the level of tumor/host interaction where the tumor as a tissue recruits and involves normal cells in its growth and survival. Targets for the therapeutic modulation (potentiation) of the antitumor alkylating agents can be divided into similar classes. Modulators that act at the level of individual tumor cells include: (1) enzyme inhibitors such as inhibitors of topoisomerase I and II, inhibitors of glutathione-S-transferase and S-glutamylcysteinyl synthase, inhibitors of DNA repair and mitochondrial toxins and (2) depletors of cellular protectors such as glutathione depletors. Modulators that act at the level of properties related to the tumor mass include: (1) agents that reverse hypoxic protection and agents that are selectively active under hypoxic conditions and (2) direct inhibitors of extracellular matrix degrading enzymes. Finally, modulators that act by inhibiting the ability of the tumor to mobilize host normal cells include: (1) inhibitors of endothelial cell proliferation such as antiangiogenic and angiostatic agents and (2) inhibitors of intercellular signaling pathways such as cyclooxygenase and lipoxygenase inhibitors. This review will demonstrate the potential of each of these strategies of therapeutic modulation using antitumor alkylating agents as the cytotoxic therapy.
Travesía y regresos de Alfredo Bryce : La última mudanza de Felipe Carrillo (2004)

En este resumen aparecen desperdigados casi todos los elementos claves de Felipe Carrillo, la búsqueda de orígenes (desdoblada en el motivo edípico y en el acoplamiento con la mulata peruana) y el repliegue intertextual de Cíen años de soledad, no declarado explícitamente por el texto que, en cambio, sí se refiere a otro de los intertextos fundamentales en la construcción de la ficción: Rayuela.4 (Algo más obvias son las referencias a El mundo es ancho y ajeno y a Los ríos profundos que no llegan, sin embargo, a operar como conmutadores del sentido sino como marcas o hitos casi obligatorios en el acercamiento del narrador a sus orígenes peruanos).
CHANGES IN ASTIGMATISM DURING THE FIRST EIGHT YEARS OF SCHOOL ??? AN INTERIM REPORT FROM THE OJAI LONGITUDINAL STUDY (1963)

School of Optometry, University of California Berkeley, California *Read before the annual meeting of the American Academy of Optometry. Miami Beach, Florida, December 11, 1962. For publication in the March, 1963, issue of the American Journal of Optometry and Archives of American Academy of Optometry. †Optometrist. Ph.D., Member of faculty. Fellow, American Academy of Optometry, Post Office Box 8 Ojai, California
Unprecedented Access to β‐Arylated Selenophenes through Palladium‐Catalysed Direct Arylation (2017)

Several reported methods allow access to α-arylated selenophenes, whereas the synthesis of β-arylated selenophenes remains very challenging. Here, the Pd-catalysed coupling of benzenesulfonyl chlorides with selenophenes affording regiospecific β-arylated selenophenes is reported. The reaction proceeds with easily accessible catalyst, base and substrates, and tolerates a variety of substituents both on the benzene and selenophene moieties. This transformation allows the programmed synthesis of polyarylated selenophenes with potential applications in pharmaceutical and materials chemistry, as the installation of aryl groups at the desired positions can be achieved.
Phase Transitions of the Ammonium Nitrate-Magnesium Nitrate System. (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhase Transitions of the Ammonium Nitrate-Magnesium Nitrate System.Edward J. GriffithCite this: J. Chem. Eng. Data 1963, 8, 1, 22–25Publication Date (Print):January 1, 1963Publication History Published online1 May 2002Published inissue 1 January 1963https://doi.org/10.1021/je60016a005RIGHTS & PERMISSIONSArticle Views285Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (480 KB) Get e-Alerts Get e-Alerts
Growth Factor Priming Differentially Modulates Components of the Extracellular Matrix Proteome in Chondrocytes and Synovium-Derived Stem Cells (2014)

To make progress in cartilage repair it is essential to optimize protocols for two-dimensional cell expansion. Chondrocytes and SDSCs are promising cell sources for cartilage repair. We previously observed that priming with a specific growth factor cocktail (1 ng/mL transforming growth factor-β1, 5 ng/mL basic fibroblast growth factor, and 10 ng/mL platelet-derived growth factor-BB) in two-dimensional culture, led to significant improvement in mechanical and biochemical properties of synovium-derived stem cell (SDSC)-seeded constructs. The current study assessed the effect of growth factor priming on the proteome of canine chondrocytes and SDSCs. In particular, growth factor priming modulated the proteins associated with the extracellular matrix in two-dimensional cultures of chondrocytes and SDSCs, inducing a partial dedifferentiation of chondrocytes (most proteins associated with cartilage were down-regulated in primed chondrocytes) and a partial differentiation of SDSCs (some collagen-related proteins were up-regulated in primed SDSCs). However, when chondrocytes and SDSCs were grown in pellet culture, growth factor-primed cells maintained their chondrogenic potential with respect to glycosaminoglycan and collagen production. In conclusion, the strength of the label-free proteomics technique is that it allows for the determination of changes in components of the extracellular matrix proteome in chondrocytes and SDSCs in response to growth factor priming, which could help in future tissue engineering strategies.
Intermittent high-dose treatment with erlotinib enhances therapeutic efficacy in EGFR-mutant lung cancer (2015)

// Jakob Schöttle 1,2,3 , Sampurna Chatterjee 1,2,10 , Caroline Volz 1,2 , Maike Siobal 2 , Alexandra Florin 4 , Dennis Rokitta 5 , Yvonne Hinze 6 , Felix Dietlein 3 , Dennis Plenker 3 , Katharina König 4 , Kerstin Albus 4 , Johannes M. Heuckmann 7 , Daniel Rauh 8 , Thomas Franz 6 , Bernd Neumaier 2,9 , Uwe Fuhr 5 , Lukas C. Heukamp 4,7 and Roland T. Ullrich 1,2 1 Department I of Internal Medicine, Center of Integrated Oncology Köln-Bonn, University of Cologne, Germany and Center of Molecular Medicine Cologne (ZMMK), University of Cologne, Cologne, Germany 2 Max-Planck-Institute for Metabolism, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany 3 Department of Translational Genomics, University of Cologne, Medical Faculty, Weyertal, Cologne, Germany 4 Department of Pathology, University Hospital Medical Center, University of Cologne, Cologne, Germany 5 Department of Pharmacology, University Hospital Medical Center, University of Cologne, Cologne, Germany 6 Max-Planck-Institute for Ageing, Cologne, Germany 7 NEO New Oncology AG, Cologne, Germany 8 Technical University Dortmund, Dortmund, Germany 9 Institut für Radiochemie und Experimentelle Molekulare Bildgebung (IREMB), University Hospital Medical Center, University of Cologne, Cologne, Germany 10 Department of Radiation Oncology, Cox-7, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA Correspondence to: Roland T. Ullrich, email: // Keywords : lung cancer, NSCLC, EGFR, erlotinib, high-dose scheduling, PET Received : July 09, 2015 Accepted : October 01, 2015 Published : November 02, 2015 Abstract Treatment with EGFR kinase inhibitors improves progression-free survival of patients with EGFR-mutant lung cancer. However, all patients with initial response will eventually acquire resistance and die from tumor recurrence. We found that intermittent high-dose treatment with erlotinib induced apoptosis more potently and improved tumor shrinkage significantly than the established low doses. In mice carrying EGFR-mutant xenografts intermittent high-dose treatment (200 mg/kg every other day) was tolerable and prolonged progression-free survival and reduced the frequency of acquired resistance. Intermittent EGFR-targeted high-dose schedules induce more profound as well as sustained target inhibition and may afford enhanced therapeutic efficacy.
Larval Environmental Temperature and the Susceptibility of <i>Aedes albopictus</i> Skuse (Diptera: Culicidae) to Chikungunya Virus (2009)

A key feature in the recent widespread epidemic of the mosquito-borne alphavirus chikungunya virus (CHIKV) was the important role of Aedes albopictus, formerly regarded as a secondary vector, compared to the presumed primary vector Aedes aegypti. Ae. albopictus, a container-inhabiting mosquito, is an invasive species that occurs over a wide geographic range spanning tropical and temperate latitudes. In this study we examine the effects of a broad range of larval rearing temperatures on CHIKV infection, dissemination, and viral titer in Florida F(1) Ae. albopictus. Adults from larvae reared at 18 degrees C, 24 degrees C, and 32 degrees C differed significantly in size, development time, and CHIKV infection rate. Adult females with the largest body size were produced from the coolest temperature, took the longest to mature, and six times more likely to be infected with CHIKV than females reared at 32 degrees C. There was also a significant effect of rearing temperature on viral dissemination, resulting in an increase in population dissemination at the coolest temperature. This study indicates that climate factors, such as temperature, experienced at the larval stage, can influence the competence of adult females to vector arboviruses.
Phylogenomics of 10,575 genomes reveals evolutionary proximity between domains Bacteria and Archaea (2019)

Rapid growth of genome data provides opportunities for updating microbial evolutionary relationships, but this is challenged by the discordant evolution of individual genes. Here we build a reference phylogeny of 10,575 evenly-sampled bacterial and archaeal genomes, based on a comprehensive set of 381 markers, using multiple strategies. Our trees indicate remarkably closer evolutionary proximity between Archaea and Bacteria than previous estimates that were limited to fewer "core" genes, such as the ribosomal proteins. The robustness of the results was tested with respect to several variables, including taxon and site sampling, amino acid substitution heterogeneity and saturation, non-vertical evolution, and the impact of exclusion of candidate phyla radiation (CPR) taxa. Our results provide an updated view of domain-level relationships.