gebhart/patrepeval huggingface dataset:
A framework for robust measurement-based admission control (1997)

Measurement-based Admission Control (MBAC) is an attractive mechanism to concurrently offer Quality of Service (QoS) to users, without requiring a-priori traffic specification and on-line policing. However, several aspects of such a system need to be clearly understood in order to devise robust MBAC schemes. Through a sequence of increasingly sophisticated stochastic models, we study the impact of parameter estimation errors, of flow arrival and departure dynamics, and of estimation memory on the performance of an MBAC system.We show that a certainty equivalence assumption, i.e., assuming that the measured parameters are the real ones, can grossly compromise the target performance of the system. We quantify the improvement in performance as a function of the memory size of the estimator and a more conservative choice of the certainty-equivalent parameters. Our results yield valuable new insight into the performance of MBAC schemes, and represent quantitative guidelines for the design of robust schemes.
Leukemias related to treatment with DNA topoisomerase II inhibitors* (2001)

The epipodophyllotoxins etoposide and teniposide and other DNA topoisomerase II inhibitors including anthracyclines and dactinomycin are highly efficacious anticancer drugs. All are associated with a distinct form of leukemia characterized by chromosomal translocations as a treatment complication. Most of the translocations disrupt a breakpoint cluster region (bcr) of the MLL gene at chromosome band 11q23. Other characteristic translocations also may occur. The normal function of the nuclear enzyme DNA topoisomerase II is to catalyze changes in DNA topology between relaxed and supercoiled states by transiently cleaving and re-ligating both strands of the double helix. Anticancer drugs that are DNA topoisomerase II inhibitors are cytotoxic because they form complexes with DNA and DNA topoisomerase II. The complexes decrease the re-ligation rate, disrupt the cleavage-re-ligation equilibrium, and have a net effect of increasing cleavage. The increased cleavage damages the DNA and leads to chromosomal breakage. Cells with irreparable DNA damage die by apoptosis. The association of DNA topoisomerase II inhibitors with leukemia suggests that the drug-induced, DNA topoisomerase II-mediated chromosomal breakage may be relevant to translocations in addition to this anti-neoplastic, cytotoxic action. Epidemiological studies, genomic translocation breakpoint cloning and in vitro DNA topoisomerase II cleavage assays together lead to a model for treatment-related leukemia in which DNA topoisomerase II causes chromosomal breakage and translocations form when the breakage is repaired.
Early treatment with nasal continuous positive airway pressure in very low‐birth‐weight infants (1993)

During 1988 and 1989, a regional cohort of 81 infants with birth weights less than 1501 g were treated with oxygen only (n = 11), early continuous positive airway pressure (CPAP) (n = 68) or mechanical ventilation from birth (n = 2). We used an easily applicable lightweight CPAP system with nasal prongs and a gas jet supplemented with ventilator treatment if necessary, but with conservative criteria for ventilator treatment with tolerance of high PCO2. A total of 65 infants (80%) survived to discharge, 61 of whom were supported solely with CPAP or oxygen. Nineteen infants (26%) developed periventricular-intraventricular haemorrhage, but only 4 survivors (6%) developed prognostically significant bleedings grade 2-4. No survivors had bronchopulmonary dysplasia. Follow-up at 12-39 months of age revealed definite disabilities in 6 (10%) and suspected disabilities in 2 of 62 long-term survivors. The results suggest that treatment by early CPAP with nasal prongs with tolerance of high PCO2 may be effective and lenient in most infants more than 25 weeks' gestation.
Future BiCMOS technology for scaled supply voltage (2003)

A BiCMOS technology for future scaled supply voltage, V/sub x/, is described. Delay time reduction by around 100 ps is achieved by introducing a proposed base electrode surround emitter transistor (BEST). Two types of gates, CBiCMOS and BiNMOS, provide shorter gate delays and higher drivabilities than the CMOS gate even with V/sub s/, of 3.3 V. It is concluded that the innovations in the bipolar transistor structure BEST and in the CBiCMOS and BiNMOS gate circuit configuration are highly promising in comparison to CMOS ULSIs for future high-speed and high-density ULSIs operating at scaled supply voltages.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The synthesis of a di-N-heterocyclic carbene-amido complex of palladium(<scp>ii</scp>) (2004)

A diimidazolium salt incorporating a secondary amine moiety has been used to prepare a palladium(II) di-N-heterocyclic carbene amino complex that can be deprotonated with NaH to give the first example of a transition metal NHC-amide.
An Improved Preparation of 3,5-Bis(trifluoromethyl)acetophenone and Safety Considerations in the Preparation of 3,5-Bis(trifluoromethyl)phenyl Grignard Reagent (2003)

An improved and efficient bromination of 3,5-bis(trifluoromethyl)benzene was developed. A safe and reliable preparation of the potentially explosive 3,5-bis(trifluoromethyl)phenyl Grignard and 3-trifluoromethylphenyl Grignard reagents, from the precursor bromides, is described. Reaction System Screening Tool (RSST) and Differential Thermal Analysis (DTA) studies suggest these trifluoromethylphenyl Grignard reagents can detonate on loss of solvent contact or upon moderate heating. When prepared and handled according to the methods described herein, these Grignard reagents can be safely prepared and carried on to advanced intermediates.
QT Prolongation Through hERG K<sup>+</sup> Channel Blockade: Current Knowledge and Strategies for the Early Prediction During Drug Development (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Stereoretentive Pd-Catalyzed Kumada–Corriu Couplings of Alkenyl Halides at Room Temperature (2014)

Stereoselective palladium-catalyzed Kumada-Corriu reactions of functionalized alkenyl halides and a variety of Grignard reagents, including those bearing β-hydrogen atoms and sensitive functional groups, can be carried out at room temperature using a new combination of reagents.
High efficiency polarization-sensitive organic photovoltaic devices (2006)

We report the fabrication of polarization-sensitive photovoltaic devices made of heterojunction-type vacuum-sublimed multilayer films composed of aligned 3,4,9,10-perylenetetracarboxylic-bis-benzimidazole (aligned PTCBI) and titanyl phthalocyanine (TiOPc). The PTCBI layer was made to be well aligned without losing high power conversion efficiency. The device configuration was ITO/In/aligned PTCBI/TiOPc/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)/Au, and the thickness of each layer was optimized for polarization-sensitive photodetection. The power conversion efficiencies under polarized white light parallel and perpendicular to the molecular orientation axis were 0.78% and 0.45%, respectively. When monochromatic polarized light at 540nm was used, the photocurrent ratio of the parallel to the perpendicular condition reached a maximum of 2.32.
Use of the pitch synchronous wavelet transform as a new decomposition method for WI (2002)

A new characteristic waveform decomposition method based on wavelets is proposed for the waveform interpolation (WI) paradigm. In WI, pitch-cycle waveforms are filtered in the evolution domain to decompose the signal into two waveform surfaces, one characterising voiced speech and a second representing unvoiced speech. The slow roll-off of FIR filters leads, however, to a significant inter-relationship between the decomposed surfaces. We present the pitch synchronous wavelet transform (PSWT) as an alternative decomposition mechanism. Filtering is again performed in the evolutionary waveform domain, producing characteristic surfaces at several resolutions. This multi-scale characterisation leads to more flexible quantisation of parameters, especially at higher rates than WI's 2.4 kb/s. FIR filters are replaced in the wavelet filter bank by causal, stable FIR filters which achieve significant delay reductions over their IIR counterparts. Furthermore, FIR filters track the dynamic aspects of the evolutionary surfaces faster, overcoming problems existing in the current WI decomposition.
Surface modification of polyethylene by radiation-induced grafting for adhesive bonding. III. Oxidative degradation and stabilization of grafted layer (1978)

Vapor-phase mutual grafting of methyl acrylate (MA) onto polyethylene (PE) and subsequent saponification treatment produce a surface graft having a high adhesive bondability, which results from the presence of a hydrolized homopolymer layer (consisting of only monomer component) on an inner graft copolymer layer consisting of both PE and monomer components. The oxidative deterioration and the stabilization of the grafted surface layer have been investigated to clarify the long-term stability of the adhesive bondability. The bondability rapidly disappears with accelerated weathering followed by acetone extraction treatment, whereas it is kept unchanged during thermal-oxidative aging at 100°C. Microscopic and ATR infrared spectroscopic observations of the degraded surfaces show that the bondability loss is due to degradative removal of the surface homopolymer layer. The addition of combinations of conventional antioxidants and ultraviolet absorbers stabilizes the grafted surface layer against thermal-oxidative and photo-oxidative degradation and thus extends the bondability retention time. The stabilization is more effective in the grafts of carbon black-containing PE, where carbon black is present in the inner-graft copolymer layer.
Quality Measures in Health Care (1996)

This article discusses measurement of quality in health care. The authors attempt to answer the following questions: why measure quality, and what will quality measurement do? The current quality measurement system is described including definitions of the measurable aspects of health care and current measurement tools. Finally, suggested benchmarks for various health care measurements are included.
Diagnostic model processor: Using deep knowledge for process fault diagnosis (1990)

Abstract Many recent attempts to use expert systems for process fault diagnosis have included information derived from deep knowledge. This information is generally implemented as a rule‐based expert system. Drawbacks of this architecture are a lack of generality, poor handling of novel situations, and a lack of transparency. An algorithm called the diagnostic model processor is introduced; it uses the satisfaction of model equations from process plants to arrive at the most likely fault condition. The method is generalized by the process model and diagnostic methodology being separated. The architecture addresses each of the shortcomings discussed. Experiments show that the methodology is capable of correctly identifying fault situations. Furthermore, information is derived from an a priori analysis technique, which is used to show the degree to which different faults can be discriminated based on the model equations available. The results of this analysis add further insight into the diagnoses provided by the diagnostic model processor.
Groupe de Travail Sur la Qualité des Images et le Choix des Sites (1970)

Bien que ce groupe n’est pas été formellement dissous, on doit constater qu’à part une séance lors de l’Assemblée Générale de Hambourg, aucune activité dans le cadre de l’UAI ne s’est manifestée dans ce domaine depuis le Symposium No. 19, tenu à Rome en 1962. Cette réunion répondait à un besoin et le volume de ses Comptes-Rendus a suscité un intérêt certain. Mais au-delà, chacun des groupes intéressés à une prospection a organisé son travail selon ses propres conceptions, en fonction des conditions géographiques qui lui étaient fixées et des moyens matériels mis à sa disposition. Il en résulte que si les méthodes d’évaluation de la qualité des images ont été quelque peu passées au crible de la critique internationale, peu de progrès ont été faits dans le sens d’une comparaison significative à l’échelle mondiale entre des sites inclus dans des campagnes de prospection différentes. Force est bien de regretter ce non-aboutissement, tout en accordant aux responsables des divers opérations l’excuse du délai généralement limité qui leur est imparti, et l’impossibilité d’attendre la mise au point d’une normalisation internationale. Un “groupe interne” de la Commission 9, au sens défini dans la première partie de ce Rapport, pourrait se consacrer à cette importante question.
Motion Pictures in Relief (1929)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Herbert E. Ives, "Motion Pictures in Relief," J. Opt. Soc. Am. 18, 118-122 (1929) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
High-quality-factor double Fabry–Perot plasmonic nanoresonator (2017)

Fabry-Perot (FP)-like resonances have been widely described in nanoantennas. In the original FP resonator, a third mirror can be added, resulting in a multimirror interferometer. However, in the case of a combination of nanoantennas, it has been reported that each cavity behaves independently. Here, we evidence the interferences between two FP absorbing nanoantennas through a common mirror, which has a strong impact on the optical behavior. While the resonance wavelength is only slightly shifted, the level of absorption reaches nearly 100%. Moreover, the quality factor increases up to factor 7 and can be chosen by geometric design over a range from 11 to 75. We demonstrate, thanks to a simple analytical model, that this coupling can be ascribed to a double FP cavity resonance, with the unique feature that each cavity is separately coupled to the outer medium.
Microarray analysis of p53-dependent gene expression in response to hypoxia and DNA damage (2007)

Hypoxia is a common feature of solid tumors and promotes resistance to apoptosis from cancer therapies that induce DNA damage. The mechanism for this resistance, however, remains unclear. Since activation of the p53 pathway plays a major role in determining whether cells undergo apoptosis in response to DNA damage, we performed a microarray analysis of p53-dependent gene expression changes in response to DNA damage combined with hypoxia. When the H460 human lung cancer cell line was treated with hypoxia and etoposide, a chemotherapy agent that induces double-stranded DNA breaks, the dominant transcriptional response was regulated by DNA damage in a p53-dependent manner. Interestingly, however, DNA damage combined with hypoxia modulated both the intensity of the p53 response and the composition of downstream target genes. For example, there was synergistic activation of known p53 target genes such as p21 and gadd45, and the unique induction of other potentially novel p53 target genes including Rad and I-Rel. In addition, analysis of repressed genes supported a model for antagonism of c-Myc signaling in hypoxia, based on the downregulation of several known c-Myc target genes and the induction of Mxi1, a c-Myc antagonist. These data suggest a hypothesis that the combination of hypoxia and DNA damage promotes resistance to therapy by eliciting a transcriptional response that favors cell cycle arrest over apoptosis.
Design and Synthesis of [(2,3-Dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as Novel Ligands Selective for the Dopamine D<sub>3</sub>Receptor Subtype (2001)

The dopamine D3 receptor subtype has been recently targeted as a potential neurochemical modulator of the behavioral actions of psychomotor stimulants, such as cocaine. However, definitive behavioral investigations have been hampered by the lack of highly selective D3 agonists and antagonists. In an attempt to design a novel class of D3 ligands with which to study this receptor system, a series of chemically divergent compounds that possessed various structural features that exist within several classes of reputed D3 agents was screened and compared to the recently reported NGB 2904 (58b). On the basis of these results, a novel series of compounds was designed that included functional moieties that were required for high-affinity and selective binding to D3 receptors. All the compounds in this series included an aryl-substituted piperazine ring, a varying alkyl chain linker (C3-C5), and a terminal aryl amide. The compounds were synthesized and evaluated in vitro for binding in CHO cells transfected with human D2, D3, or D4 receptor cDNAs. D3 binding affinities ranged from K(i) = 1.4 to 1460 nM. The most potent analogue in this series, 51, demonstrated a D3/D2 selectivity of 64 and a D3/D4 selectivity of 1300. Structure-activity relationships for this class of ligands at D3 receptors will provide new leads toward the development of highly selective and potent molecular probes that will prove useful in the elucidation of the role D3 receptors play in the psychomotor stimulant and reinforcing properties of cocaine.
Identities of Structure Constants for Schubert polynomials and Orders on S_n (1997)

We use geometry to prove a number of new identities among the Littlewood-Richardson coefficients for Schubert polynomials (Schubert classes in a flag manifold). For many of these identities, there is a companion result about the Bruhat order which should imply the identity, were it known how to express these coefficients in terms of the Bruhat order. This analysis leads the determination of many of these constants. We conclude with an outline of geometric proofs for these identities.
Human microRNAs target a functionally distinct population of genes with AT-rich 3′ UTRs (2005)

While investigating microRNA targets, we have found that human genes divide into two roughly equal populations, based on the fraction of A plus T bases in their 3' UTRs. Using the Gene Ontology database, we find significant functional differences between the two gene populations, with AT-rich genes implicated in transcription and translation processes, and GC-rich genes implicated in signal transduction and posttranslational protein modification. Better understanding of the background distribution of nucleotides in 3' UTRs may allow improved prediction of microRNA-targeted genes in humans. We predict at least 1,200 KnownGene transcripts to be regulated by microRNAs. The large majority of these microRNA targets are in the AT-rich 3' UTR population. However, notwithstanding this preference for AT-rich targets, microRNA targets are found preferentially to be regulatory genes themselves, including both transcription factors and posttranslational modifiers. These results suggest that some processes involving mRNA, of which microRNA regulation may be just one, require AT-richness of 3' UTRs for functionality. A relationship, not simply one-to-one, between these 3' UTR populations and large-scale genomic isochores is described.
Halogen-atom-transfer annulations involving iodomalonates and allylamine derivatives (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHalogen-atom-transfer annulations involving iodomalonates and allylamine derivativesDaniel L. Flynn and Daniel L. ZabrowskiCite this: J. Org. Chem. 1990, 55, 11, 3673–3674Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/jo00298a058https://doi.org/10.1021/jo00298a058research-articleACS PublicationsRequest reuse permissionsArticle Views238Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intratumoral cisplatin/epinephrine‐injectable gel as a palliative treatment for accessible solid tumors: A multicenter pilot study (1998)

Intratumoral injections of cisplatin/epinephrine‐injectable gel were administered weekly for 4 weeks in 45 patients with malignant tumors of various histologic types. Tumors were located on the skin and subcutaneous tissue primarily of the head, neck, and trunk, and on the tongue, oral pharynx, and esophagus. Patients were not candidates for surgery, radiation, or systemic chemotherapy. Each of the treated tumors ( n = 82) was evaluated 2, 4, 8, and 12 weeks after the final injection. The initial dose of cisplatin was 1 mg/cm 3 tumor volume, with escalation to 6 mg/cm 3 allowed, depending on observed toxicities. The mean cumulative dose per patient for the four treatments ranged from 0.56 to 380 mg cisplatin. No dose‐limiting cisplatin‐related toxicities, such as nephrotoxicity, neurotoxicity, or ototoxicity, were observed. The overall objective tumor response rate was 50% (41 of 82), with 40% (33 of 82) complete responses and a median response duration of 160 days. Complete responses for adenocarcinoma and squamous cell carcinoma were 58% (21 of 36) and 38% (12 of 32), respectively. These results justified further clinical trials to evaluate the role of local chemotherapy with intratumoral cisplatin/epinephrine‐injectable gel in the palliative treatment of patients with selected accessible solid tumors.