gebhart/patrepeval huggingface dataset:
Identification of the Nuclear Localization Signal of Rat Liver CTP:Phosphocholine Cytidylyltransferase (1995)

CTP:phosphocholine cytidylyltransferase (CT) is a major regulatory enzyme in phosphatidylcholine synthesis in mammalian cells. CT is found in both soluble and particulate forms, both of which are nuclear. We report here the identification of a 21-residue sequence at the amino terminus of CT, 8KVNSRKRRKEVPGPNGATEED28, which was sufficient to direct beta-galactosidase into the cell nucleus. Further deletions from either end of this sequence greatly reduced the nuclear localization of beta-galactosidase. Deletions of amino acids within the nuclear localization signal or of the entire signal disrupted CT nuclear localization, but CT was not completely excluded from the nucleus. Clones of stable transfectants of the nuclear localization signal-deficient CT expressed in Chinese hamster ovary (CHO) 58 cells, which is temperature-sensitive for growth and CT activity, were isolated and characterized. The deletion mutants were active under the same conditions as the wild-type enzyme. Despite the difference in subcellular location from wild-type CT, the nuclear localization mutants were fully able to complement the CT-deficient cell line CHO 58 for both growth and choline incorporation into phosphatidylcholine at the nonpermissive temperature. The mobility of the mutant enzymes on SDS gels was altered relative to the mobility of wild-type CT; however, the extent of phosphorylation of the mutant enzymes was decreased only slightly. Thus, the distribution of CT in both cytoplasm and nucleus, rather than exclusively nucleus, has little effect on the ability of CT to function in growing CHO cells.
ReVive: cost-effective architectural support for rollback recovery in shared-memory multiprocessors (2003)

This paper presents ReVive, a novel general-purpose rollback recovery mechanism for shared-memory multiprocessors. ReVive carefully balances the conflicting requirements of availability, performance, and hardware cost. ReVive performs checkpointing, logging, and distributed parity protection, all memory-based. It enables recovery from a wide class of errors, including the permanent loss of an entire node. To maintain high performance, ReVive includes specialized hardware that performs frequent operations in the background, such as log and parity updates. To keep the cost low, more complex checkpointing and recovery functions are performed in software, while the hardware modifications are limited to the directory controllers of the machine. Our simulation results on a 16-processor system indicate that the average error-free execution time overhead of using ReVive is only 6.3%, while the achieved availability is better than 99.999% even when the errors occur as often as once per day.
Chlorinated polyethylene modification of blends derived from waste plastics Part I: Mechanical behavior (1973)

Abstract Recycling of waste plastics as a blend of generic types is attractive since a difficult separations problem is avoided. However, blends of incompatible polymers are frequently very brittle and cannot be considered for many applications. Additives which modify the blend to give it ductility may provide a solution to this problem. Chlorinated polyethylene (CPE) made by a slurry process has been suggested for this application by Schramm and Blanchard. Further documentation of the effectiveness of this approach is given here. Addition of CPE to such a blend generally increases the elongation at break and the energy to break very dramatically with ordinarily some loss in strength and modulus. This approach works most effectively in blends of high polyethylene and poly(vinyl chloride) content. Three grades of CPE were studied here which revealed that the specific structure of the CPE molecule is a factor. The effectiveness of CPE for blend modification is believed to derive from the graded molecular structure acquired during chlorination.
Agent Honesty, Cooperation and Benevolence in an Artificial Organization (1993)

In this paper we describe an exploratory experiment in which we examined the effect of three agent social behaviors (Cooperativity, Reliability, Benevolence) on four measures of organizational performance: cognitive effort, physical effort, communication effort, and idle time.
An optimal spatial filtering electrode for brain computer interface (2009)

There are millions of people in the U.S. and many more worldwide who could benefit from a noninvasive-based electroencephalography (EEG) brain computer interface (BCI). A BCI is an alternative or augmentative communication method for people with severe motor disabilities. However, EEG suffers from poor spatial resolution and signal-to-noise ratio (SNR). To improve the spatial resolution and SNR many researchers have turned to implantable electrodes. We have previously reported on significant improvements in BCI recognition rates using tripolar concentric ring electrodes compared to disc electrodes. We now report on a optimal method for combining the outputs from the independent elements of the tripolar concentric ring electrodes to improve the spatial resolution further. We used minimum variance distortionless look (MVDL), a beamformer, on simulated data to compare the spatial sensitivity of the optimal combination to disc electrodes and the tripolar concentric ring electrode surface Laplacian. The optimal combination shows the highest spatial sensitivity with the Laplacian a close second and disc electrodes resulting in a distant third. Further analysis is necessary with a more realistic computer model and then real signals. however it appears that the optimal combination may improve the spatial resolution of EEG further which in turn can be utilized to improve noninvasive EEG-based BCIs.
Interactive Reservoir Simulation With the World Wide Web (1997)

Summary Technology transfer through the World Wide Web (WWW) allows efficient use of available computing resources. A centralized highspeed computer can be accessed through the Internet by many users (independents) who otherwise may be handicapped by lack of such resources. The Petroleum Technology Transfer Council (PTTC) has a regional lead office in New Mexico dedicated to this objective. As an example of sharing resources, we have coupled an automatic history-matching algorithm to an analytical polymer/waterflood simulator that may be accessed over the Internet. The polymer/waterflood predictive model (PFPM) was developed for the U.S. Dept. of Energy (DOE) and is available to the public as a freeware from the Internet site http://www.bpo.gov. The simulator has been tested by various users over a period of time and is considered to be reliable. We attached a user-friendly, Web-based graphical user interface (GUI) to the PFPM model and put it on a fast, dedicated Internet server. This paper describes the development and implementation of this new Internet-based, interactive simulation tool.
Modeling Goes to Hollywood: Predicting Individual Differences in Movie Enjoyment (1994)

Consumer behavior researchers are getting more interested in the experiential aspect of consumption, which focuses on the fun and enjoyment that consumers derive from hedonic experiences. We build upon the experiential view of consumer behavior, and present an innovative modeling approach to studying the dynamics of hedonic consumption experiences. We develop a conceptual framework for the enjoyment of a hedonic experience, in which we propose that the enjoyment of the experience is an outcome of the dynamic interaction between stable individual difference factors, temporary moods, and the emotional content of the experience. We present an application of the conceptual framework in the context of a movie viewing experience. We model the interaction between the temporary moods of an individual and the emotional content of the movie as a stochastic process. This interaction determines the individual's instantaneous emotional states. We develop analytical expressions for the dynamic evolution of the probability distribution of the levels of achieved emotional stimulation, and, through individual difference factors, the expected enjoyment. All measurements are taken prior to watching the movie. We use these measurements to predict individual differences in the ex-post enjoyment of the movie. We present an empirical test of the movie enjoyment model (ENJMOD), and find encouraging results at the individual and segment level. We discuss the implications of our modeling approach for the segmentation and testing of movies, and for the prediction of consumer response to similar experiential products.
Dealing with Crystal Forms (The Kingdom of Serendip?) (2011)

The variety of crystal forms that may be associated with one specific molecule of interest can be extremely large: in addition to polymorphs, all sorts of crystalline solids can be obtained, from molecular and ionic co-crystals to hydrates/solvates, to, needless to say, polymorphs of all these new crystal forms. Lack of predictability of crystallization experiments, far from representing a failure or a nuisance, should encourage in the crystal maker the same attitude shown by the three princes of Serendip (who were making unexpected discoveries by virtue of their "sagacity and readiness of mind") to be ready to pick new avenues as the crystal experiments will yield something unplanned for.
A software structure for flexible IN service operations (2002)

To provide a network that can meet customer demands quickly and economically, we are developing an advanced Intelligent Network (IN). These days, service management and operations are an important area of study in advanced INs. The provision of flexible operations using Operations Logic Programs (OLPs) has become a particularly topical issue. Since support for various advanced IN services will be added to our network quickly, new service-dependent operations functions must be provided immediately to support the services on demand. Existing OpSs, however, generally focus on one or more existing services, so it is difficult that they can handle new ones quickly. To compensate for the lack of new operations functions in existing OpSs, we are developing a service operations system (SOpS) and service operations workstations (OpWSs). These each have their own Service-Independent Operations Platform (SIOP). They also have Service-Independent/Dependent Operations Function Building Blocks (SI/DOFB), like Service Independent Building Block (SIB). The SIOP can execute OLPs by using these SI/DOFBs. The SOpS and OpWSs consequently enable flexible advanced IN service operations. This presentation first explains NTT's advanced IN architecture. Next, we discuss the requirements of the SOpS and OpWSs. Then, we overview their system structures, OLPs, and SIOPs. Finally, we describe how to install new service-dependent operations functions on them.
BTI and charge trapping in germanium p- and n-MOSFETs with CVD HfO/sub 2/ dielectric (2006)

High performance Ge p- and n-MOSFETs with CVD HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gate dielectric were fabricated. Charge trapping and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> instability were investigated systematically for the first time for Ge MOSFET with different surface treatments (silicon passivation and surface nitridation) and compared to the Si devices. Our results show that: (1) Ge devices with silicon passivation yield better electrical performance and reliability than those with surface nitridation; (2) Ge transistors with silicon passivation exhibit less NBTI degradation than the silicon counterparts; probably due to the larger hole barrier in Ge/dielectric than in Si/dielectric; and (3) PBTI degradation of the Ge transistors is more severe than the silicon devices, which imposes an important reliability issue for Ge CMOS applications
Experimental Validation of a Time Domain Cavitation Model for Switched Inertance Circuits (2017)

Switched inertance hydraulic systems are switch mode fluid power circuit topologies that allow the load pressure to be modulated in an efficient manner. A unique feature of these circuits is a long, small diameter, inertance tube, which stores energy in the fluid kinetic domain during a switching cycle. A barrier to application of these circuits is that current models require an elevated reservoir pressure, which is difficult to implement in practice. Research has focused on analyzing inertance tube wave delay effects in the frequency domain, which necessarily excludes non-linear physical phenomena such as cavitation and pressure dependent wave speed. A circuit with an ambient reservoir pressure exposes the fluid in the inertance tube to local pressure conditions where these non-ideal behaviors may have a strong effect on system dynamics. In this paper, a method of characteristics cavitation model with unsteady friction is presented that accurately captures the incidence and severity of cavitation in a long pipeline undergoing cyclic high and low pressure boundary conditions. This model is validated experimentally by examining the pressure response in a 3.95m steel pipeline with an upstream switching valve capable of 0.5ms transition at 120Hz. Experiments are conducted over a range of switching frequencies at 60% duty. The proposed pipeline model can be used to predict conditions leading to cavitation as well as help develop cavitation avoidance strategies, such as soft switching and utilization of line resonance.
A colorimetric method for the determination of methyl bromide in air (1955)

G. A. Lugg, Analyst, 1955, 80, 290 DOI: 10.1039/AN9558000290
Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5. (2006)

This study demonstrates the feasibility of noninvasive imaging of atherosclerosis with radiolabeled annexin A5 in transgenic mouse models of human atherosclerosis.
Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring (2006)

We demonstrate a linear laser resonator incorporating a semiconductor optical amplifier and scanning filter for high repetition rate, broad wavelength, unidirectional scanning. The laser operates at up to 115kHz repetition rates and demonstrates a tuning-speed-independent power of &gt;30mW. We apply this laser to enable ultrahigh-speed optical frequency domain imaging of the dynamics of laser ablation of biological tissue. The imaging system acquires single longitudinal scans (A-lines) in 8.7μs and complete cross-sectional images comprising 575A-lines at a rate of 200 frames per second.
Frequencies of Different Types of Colour Vision Defects in the Netherlands (1978)

Two different population samples in Holland – one consisting of 1,093 boys from a technical school and the other of 493 male and 416 female students – were analysed for the presence of red-green colour vision defects. A total percentage of 7.3 for the male population was found. Based on the combined results of the Ishihara and HRR pseudoisochromatic plates, the Farnsworth 15-hue test and the anomaloscope, a subdivison of the deuteranomalous individuals into 3 subgroups is made. It is suggested that the differences between these groups may be genetic in nature and that the actual number of different genetic entities may still be greater.
Exact Correction of Sharply Varying Off-Resonance Effects in Spiral MRI (2006)

Magnetic resonance imaging with non-Cartesian acquisition schemes suffer from blurring artifacts induced by off-resonance. Conventional algorithms for off-resonance correction are approximate in nature and assume that the off-resonance map is varying smoothly across the object. This assumption is violated in the case of susceptibility related off-resonance which is sharply varying near certain tissue interfaces. Iterative methods have been proposed for sharply varying off-resonance correction but are either computationally intense in the exact form or need approximations like time segmentation to reduce computational cost. Here a new method for accurate and computationally efficient off resonance correction using spatial domain deconvolution is presented.
<b>Rearrangements of 4,5-Oxidocholestane-3-one</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRearrangements of 4,5-Oxidocholestane-3-oneWilliam. Reusch and Ronald. LeMahieuCite this: J. Am. Chem. Soc. 1963, 85, 11, 1669–1672Publication Date (Print):June 1, 1963Publication History Published online1 May 2002Published inissue 1 June 1963https://pubs.acs.org/doi/10.1021/ja00894a029https://doi.org/10.1021/ja00894a029research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Computational techniques for solving the bidomain equations in three dimensions (2002)

The bidomain equations are the most complete description of cardiac electrical activity. Their numerical solution is, however, computationally demanding, especially in three dimensions, because of the fine temporal and spatial sampling required. This paper methodically examines computational performance when solving the bidomain equations. Several techniques to speed up this computation are examined in this paper. The first step was to recast the equations into a parabolic part and an elliptic part. The parabolic part was solved by either the finite-element method (FEM) or the interconnected cable model model (ICCM). The elliptic equation was solved by FEM on a coarser grid than the parabolic problem and at a reduced frequency. The performance of iterative and direct linear equation system solvers was analyzed as well as the scalability and parallelizability of each method. Results indicate that the ICCM was twice as fast as the FEM for solving the parabolic problem, but when the total problem was considered, this resulted in only a 20% decrease in computation time. The elliptic problem could be solved on a coarser grid at one-quarter of the frequency at which the parabolic problem was solved and still maintain reasonable accuracy. Direct methods were faster than iterative methods by at least 50% when a good estimate of the extracellular potential was required. Parallelization over four processors was efficient only when the model comprised at least 500,000 nodes. Thus, it was possible to speed up solution of the bidomain equations by an order of magnitude with a slight decrease in accuracy.
On the intrinsic spacer layer in Si/SiGe heterojunction bipolar transistor grown by ultra high vacuum chemical vapor deposition (1997)

In this paper, we report the study on the intrinsic SiGe spacer layer in Si/SiGe HBT and a novel phenomenon in Si/SiGe HBT layer structure grown by ultra high vacuum chemical vapor deposition (UHVCVD) using Si/sub 2/H/sub 6/ and GeH/sub 4/. When intrinsic SiGe spacer layer width decreases from 100 A to 75 A, the BC junction turn-on voltage decreases from /spl sim/0.6 V to /spl sim/0.2 V, while the BE junction turn-on voltage remains /spl sim/0.6 V. As a result, the offset voltage of the HBT operated at common emitter configuration increases from nearly zero to /spl sim/0.4 V. Therefore, 100 A is used as the intrinsic SiGe spacer layer width. Furthermore, the Si/SiGe HBT layer structures with different SiGe spacer layer widths grown by UHVCVD were investigated by cross-sectional transmission electron microscopy (XTEM). It is shown that a Ge-rich very thin layer exists in the strained SiGe layer grown on Si, which is in parallel with the interface of SiGe and Si. When the SiGe spacer layer width decreases from 100 A to 75 A, the Ge-rich thin layer moves closer to the interface of SiGe base and Si collector, and makes the BC junction turn-on voltage decrease, the offset voltage of HBT, therefore, increases.
A Screening System for the Directed Evolution of Epoxygenases: Importance of Position 184 in P450 BM3 for Stereoselective Styrene Epoxidation (2006)

Positively charged: A screening system for the directed evolution of epoxygenases has been developed. Validation reveals that introducing a positively charged amino acid at position 184 (see picture) results in inversion of enantioselectivity in the epoxidation of styrene. The synthetic potential of epoxygenases can now be tailored by methods of directed evolution. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600255_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Which 5-fluorouracil regimen? — the great debate (1999)

5-Fluorouracil (5-FU) has been available for over 40 years and has been used in a wide variety of different regimens for the treatment of advanced colorectal cancer, a malignancy with a poor prognosis that is common in industrialized countries. However, despite numerous clinical trials in which 5-FU has been used alone and in combination with a variety of modulating agents [chiefly leucovorin (LV)], and has been administered by bolus injection and i.v. infusion, the optimal regimen for the management of advanced colorectal cancer remains unclear, and there are notable national and international variations in clinical practice. The toxicity of 5-FU also remains an obstacle to the achievement of overall clinical benefit in many patients. The introduction of novel chemotherapeutic agents may make it necessary to reassess the place of 5-FU in the treatment of advanced colorectal cancer. This article debates these issues with a review of clinical trials of 5-FU, and concludes that the future lies in the utilization of novel and established agents in combinations that may significantly improve outcomes, rather than in continuing experimentation with various schedules of 5-FU and LV.
Interaction of the Pisum sativum nuclear matrix proteins with SAR DNA. (1995)

We have isolated the nuclear matrices from Pisum sativum cell nuclei using three methods: i. standard procedure involving extraction of cell nuclei with 2 M NaCl and 1% Triton X-100; ii. the same with pretreatment of cell nuclei with 0.5 mM CuSO4 (stabilisation step); and iii. method including lithium diiodosalicylate extraction. We compared the polypeptide pattern and residual DNA content of the nuclear matrices isolated. The nuclear matrices displayed a specific endonuclease activity which was due to the presence of a 32 kDa protein. The isolated nuclear matrices bound specifically the scaffold-attached (SAR) DNA derived from human beta interferon gene, in the exogenous SAR binding assay. Using the DNA-protein binding blot assay we demonstrated the presence of two nuclear matrix proteins of 66 kDa and 62 kDa which bound specifically SAR DNA.