gebhart/patrepeval huggingface dataset:
A solution to the distribution and standardization of multimedia medical data in E-Health (2001)

Electronic Patient Record (EPR) is an area of research in E-Health that is progressing rapidly due to its demand and rapid growth of Information Technology used in the Health Management Organizations (HMO). Benefits of having EPR are the timely access of critical data, inclusion of multimedia, and the ease of availability and distribution, those making it more presentable, distributable, efficient and cost-effective. A number of studies, ranging from global standardization of EPR to the building of the infrastructure to support it are being implemented. Along this trend, this paper discusses the problem in medical data standards and distribution. The proposed solution is an application that can adapt to the data used in the HMO that has the ability to automatically generate distributable EPR from any medical data.
Clinical Significance of Drug Resistance in Human Immunodeficiency Virus (1995)

Antiretroviral drugs exert only limited activity against viruses that replicate persistently to high levels. Thus, drug-resistant viruses readily emerge. It has been difficult to assess the contribution of such drug resistance to the failure of treatment with drugs that have only limited effectiveness in the first place. The emergence of zidovudine-resistant human immunodeficiency virus is predictive of clinical disease progression, although the relationship of this event to treatment failure is particularly complicated. The relationship between drug resistance and the loss of activity of non-nucleoside reverse transcriptase inhibitors and protease inhibitors appears to be more straightforward. The optimal use of antiretroviral drugs and combination regimens requires an appreciation of the impact of drug resistance.
A facile one-step synthesis of aromatic indolizines by 1,3-dipolar cycloaddition of pyridinium and related heteroaromatic ylides with alkenes in the presence of TPCD [Copy4(HCrO4)2] (1993)

A facile and general one-step method is presented for the synthesis of aromatic indolizine compounds 3a–n in moderate to high yields (53–99%) by reaction of the pyridinium N-ylides 1a–e, the quinolinium N-ylide 1f and the isoquinolinium N-ylide 1g with various olefinic dipolarophiles, such as acrylonitrile 2a, methyl acrylate 2b, acrylamide 2c, diethyl maleate 2d and methyl crotonate 2e, respectively, in the presence of a new oxidant TPCD [Copy4(HCrO4)2, tetrapyridinecobalt(II) dichromate] at 90 °C for 2 h in DMF.
Image processing through reaction combined with nonlinear diffusion (1993)

We propose a method based on nonlinear diffusion and reaction for edge detection and contrast enhancement in image processing. We prove that the mathematical model is well posed and show numerically that the processed image can be observed on the asymptotic state of its solution. We illustrate the methods on test images and show on medical images how it can help to draw contours and detect one-dimensional coherent signals.
New pharmacologic and therapeutic approaches for hypoxic-ischemic encephalopathy in the newborn (2012)

Hypoxic-ischemic encephalopathy is still an important cause of neonatal mortality and long-term disabilities. The understanding of the differential responses to hypoxia-ischemia as an initial insult leading to cellular degeneration in brain has opened the way to develop new pharmacologic and therapeutic approaches. Due to the complex pathophysiology, therapies can target early pathways such as oxidative stress, inflammation and apoptosis or delayed pathways such as the privation of growth factors and cell death. Pharmacological interventions should start at different points of time according to their mechanisms of action. The association of moderate hypothermia with neuroprotective drugs may decrease cell injury and optimize endogenous repair. More basic science research focusing on the mechanisms of injury are required. Moreover, clinical trials are needed to detect safely and effectiveness drugs and to establish the optimal time of action for each one.
Polymerized micelles: fact or fancy? (1986)

S. Hamid and D. Sherrington, J. Chem. Soc., Chem. Commun., 1986, 936 DOI: 10.1039/C39860000936
Polarimetric current sensor using an in-line Faraday rotator (2000)

A novel polarimetric fiber optics current sensor configuration using an in-line 22.5 degree Faraday rotator is proposed on this paper. The introduction of the 22.5 degree Faraday rotator allows to obtain a sensor configuration that does not require adjustment on most optical elements, resulting in an accuracy immune to manufacturing issues. Two prototypes are presented in this paper that are designed to measure AC current, yielding in an excellent accuracy over more than 3 decades.
Empirical analysis of blower cooling failure in containment: Effects on IT performance (2016)

Data Centers are prone to power outages and cooling failures. During such events, complex transport interactions take place between the cooling system and the IT. Empirical data on this phenomenon is scarce in the current literature due to the complexity and size of such experiments. In this study, a facility level data center blowers cooling failure experiment is run and analyzed. Quantitative instrumentation includes pressure differentials, tile airflow, point air inlet temperature, contours air inlet temperature and IT IPMI data during failure-recovery. Qualitative measurements include IR imaging and airflow visualization via smoke trace. To our knowledge, this is the first experimental study in literature in which an actual multi aisle facility cooling failure is run with real IT (compute, Network and storage) load in the white space. This will enable a link between variations from the facility to the chip levels. Results show that by using external air inlet temperature sensors the containment configuration has a longer uptime during failure. However, the IPMI data shows the opposite. In fact, the RTT is reduced by ∼70% when the external and internal sensors are compared. This occurs due external impedances formed by the containment during failure degrading IT airflow systems. The inconsistency between IT IPMI inlet sensors and externally placed IT or rack inlet sensors (based on best practices) are expected to increase as the airflow imbalances increase.
Quantum well oscillators (1984)

Oscillations have been observed for the first time from double barrier resonant tunneling structures. By eliminating impurities from the wells, we have been able to increase the tunneling current density by a factor of nearly 100. With the attendant increase in gain and improved impedance match to the resonant circuit, the devices oscillated readily in the negative resistance region. Oscillator output power of 5 μW and frequencies up to 18 GHz have been achieved with a dc to rf efficiency of 2.4% at temperatures as high as 200 K. It is shown that higher frequencies and higher powers can be expected.
Learning Through Imitation: a Biological Approach to Robotics (2012)

Humans are very efficient in learning new skills through imitation and social interaction with other individuals. Recent experimental findings on the functioning of the mirror neuron system in humans and animals and on the coding of intentions, have led to the development of more realistic and powerful models of action understanding and imitation. This paper describes the implementation on a humanoid robot of a spiking neuron model of the mirror system. The proposed architecture is validated in an imitation task where the robot has to observe and understand manipulative action sequences executed by a human demonstrator and reproduce them on demand utilizing its own motor repertoire. To instruct the robot what to observe and to learn, and when to imitate, the demonstrator utilizes a simple form of sign language. Two basic principles underlie the functioning of the system: 1) imitation is primarily directed toward reproducing the goals of observed actions rather than the exact hand trajectories; and 2) the capacity to understand the motor intentions of another individual is based on the resonance of the same neural populations that are active during action execution. Experimental findings show that the use of even a very simple form of gesture-based communication allows to develop robotic architectures that are efficient, simple and user friendly.
TiN–Fe nanocomposite thin films deposited by reactive magnetron sputtering (2007)

TiN–Fe films with various iron concentrations were deposited on Si and NaCl single-crystal substrates by direct current reactive magnetron sputtering. The structure and chemical composition of the films were examined by x-ray diffraction (XRD), high resolution transmission electron microscopy (HRTEM), energy-dispersive x-ray and x-ray photoelectron spectroscopy (XPS). The effects of Fe addition on the structural, mechanical and magnetic properties of TiN films were studied. XRD and HRTEM revealed for TiN–Fe a cubic B-1 structure while no sign of an iron phase was observed. It was found that the lattice parameter and the grain size decreased with an increase in the Fe/Ti atomic ratio. At Fe/Ti = 0.2, the XRD revealed a change in the preferential orientation from (1 1 1) to (2 0 0) with a tendency of line broadening as the iron concentration increased. The Fe 2p core level peak of XPS indicates that the greater part of Fe atoms in TiN–Fe films exists as free pure metallic iron while the lesser part was in the form of iron oxide. Film annealing at 500 and 600 °C led to iron precipitation of the α-Fe phase indicating that below 500 °C Fe–TiN, films can be considered as nanocomposites materials, as confirmed by nanoindentation measurements and HRTEM observations.
Rapid Nanoimprinting of Doped Silk Films for Enhanced Fluorescent Emission (2010)

Doping ease and the ability to readily nanoimprint silk films offer the possibility to rapidly prototype photonic devices that couple optical functions with embedded material properties. By imprinting fluorescent silk films with periodic nanoscale lattices matched to the emission spectra of the doping fluorophores it is possible to selectively enhance the emission from the film.
Novel Jet-Injection Technology for Nonviral Intratumoral Gene Transfer in Patients with Melanoma and Breast Cancer (2008)

Intratumoral jet injection of plasmid DNA led to efficient LacZ reporter gene expression in all patients. No side effects were experienced, supporting safety and applicability of this novel nonviral approach. A next step with a therapeutic gene product should determine antitumor efficacy of jet-injection gene transfer.
Vectofusin-1, a New Viral Entry Enhancer, Strongly Promotes Lentiviral Transduction of Human Hematopoietic Stem Cells (2013)

Gene transfer into hCD34(+) hematopoietic stem/progenitor cells (HSCs) using human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) has several promising therapeutic applications. Yet, efficiency, safety, and cost of LV gene therapy could be ameliorated by enhancing target cell transduction levels and reducing the amount of LV used on the cells. Several transduction enhancers already exist such as fibronectin fragments and cationic compounds, but all present limitations. In this study, we describe a new transduction enhancer called Vectofusin-1, which is a short cationic peptide, active on several LV pseudotypes. Vectofusin-1 is used as a soluble additive to safely increase the frequency of transduced HSCs and to augment the level of transduction to one or two copies of vector per cell in a vector dose-dependent manner. Vectofusin-1 acts at the entry step by promoting the adhesion and the fusion between viral and cellular membranes. Vectofusin-1 is therefore a promising additive that could significantly ameliorate hCD34(+) cell-based gene therapy.Molecular Therapy-Nucleic Acids (2013) 2, e90; doi:10.1038/mtna.2013.17; published online 7 May 2013.
Linearization Techniques of Reservoir Simulation Equations - IMPES/IMPEM Cases (1996)

The main object of this paper is to exarnine and compare models based on the numerical background of linearization techniques. A new transformation procedure is introduced that helps to separate the nonlinearity of the flow equations from the nonlinearity of fluid calculations. This transformation procedure can help to decide an optimal 'technique when developing a new model. In addition, it clears the real and the apparent differences among the mode Is, and it gives a possibility to arrive at a concise survey of the solution techniques. The detailed exarnination of the differences of IMPES and IMPEM techniques has revealed the origin of material balance error of the IMPES technique. The object-oriented C++ programming language was applied to the comparison studies. The basic C++ classes and member functions are presented in the Appendix at the end of the paper.
Blood Biomarkers in Stroke: Research and Clinical Practice (2012)

Blood biomarkers may have applications in stroke diagnosis, outcome prediction, or treatment. In this article, we provide a focused review on some of the methodological challenges and potential developments of biomarkers in stroke. We review the approaches to the development of a diagnostic blood marker: a candidate marker approach, marker panels, and -omics. Then we examined the role of blood markers to predict recurrent stroke and treatment response in stroke.
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP (2008)

Activity-regulated gene expression is believed to play a key role in the development and refinement of neuronal circuitry. Nevertheless, the transcriptional networks that regulate synapse growth and plasticity remain largely uncharacterized. Here, we show that microRNA 132 (miR132) is an activity-dependent rapid response gene regulated by the cAMP response element-binding (CREB) protein pathway. Introduction of miR132 into hippocampal neurons enhanced dendrite morphogenesis whereas inhibition of miR132 by 2'O-methyl RNA antagonists blocked these effects. Furthermore, neuronal activity inhibited translation of p250GAP, a miR132 target, and siRNA-mediated knockdown of p250GAP mimicked miR132-induced dendrite growth. Experiments using dominant-interfering mutants suggested that Rac signaling is downstream of miR132 and p250GAP. We propose that the miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity.
Low-dose oral methotrexate in chronic progressive multiple sclerosis (1996)

We monitored 56 patients with chronic progressive multiple sclerosis (MS) who participated in a clinical trial of weekly, low-dose oral methotrexate with annual gadolinium-enhanced MRIs of the brain (Gd + MRI). Not of these patients had clinical exacerbations during the 8 months preceding study entry. We also monitored 35 of the patients with serial Gd + MRIs every 6 weeks for 6 months. We observed a treatment effect, measured by absolute change in T2-weighted total lesion area (T2W-TLA), in the cohort that completed 6-week scans. We found change in T2W-TLA in this cohort to be significantly related to sustained change in performance on the nine-hold peg test but not to sustained change on the Expanded Disability Status Scale. Gadolinium enhancement of lesions on 6-week and annual scans was uncommon. Prestudy exacerbation frequency appears to be an important consideration in designing future clinical trials in patients with secondary and primary progressive MS.
Mary Reconsidered (2011)

This chapter first explains the reluctance of Protestants to deal with the figure of Mary, the mother of Jesus, as a reaction to certain later developments in the life of the church. In the Middle Ages as well as in the earlier age of the fathers, Mary increasingly became an object of interest in herself. It considers some of the ways in which Mary claimed the attention of medieval theologians, including the Immaculate Conception, the maternity of Mary, Mary as a covenant partner, and Mary as an intercessor. The chapter also argues that Mary is a sign that God has really intervened in human history; that Mary is a sign that God's new act in Christ stands in historical continuity with his saving acts in the Old Testament; and that the image of Mary as a type or analogue of the church is not a bad one, so long as the whole biblical witness is taken.
Ethylenebis(diphenylphosphine) complexes of iron and cobalt. Hydrogen transfer between the ligand and iron atom (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEthylenebis(diphenylphosphine) complexes of iron and cobalt. Hydrogen transfer between the ligand and iron atomGo. Hata, Hisao Kondo, and Akihisa MiyakeCite this: J. Am. Chem. Soc. 1968, 90, 9, 2278–2281Publication Date (Print):April 1, 1968Publication History Published online1 May 2002Published inissue 1 April 1968https://pubs.acs.org/doi/10.1021/ja01011a012https://doi.org/10.1021/ja01011a012research-articleACS PublicationsRequest reuse permissionsArticle Views703Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pharmacokinetics of ibafloxacin following intravenous and oral administration to healthy Beagle dogs (2002)

The pharmacokinetics of ibafloxacin, a new veterinary fluoroquinolone antimicrobial agent, was studied following intravenous (i.v.) and oral administration to healthy dogs. The mean absolute bioavailability of ibafloxacin after oral doses of 7.5, 15 and 30 mg/kg ranged from 69 to 81%, indicating that ibafloxacin was well absorbed by dogs. Ibafloxacin was also absorbed rapidly [time of maximum concentration (t(max)) 1.5 h], reaching a mean maximum concentration (C(max)) of 6 microg/mL at 15 mg/kg, well distributed in the body [large volume of distribution at steady state (V(ss)) and V(area) of 1.1 L/kg and 4 L/kg, respectively], and exhibited an elimination half-life of 5.2 h and a low total body clearance (8.7 mL/min/kg). Both C(max) and area under the concentration-time curve (AUC) showed dose proportionality over the dose range tested (7.5-30 mg/kg). The pharmacokinetics of ibafloxacin was similar following single and repeated dosage regimens, implying no significant accumulation in plasma. Food promoted the absorption of ibafloxacin by increasing C(max) and AUC, but did not change t(max). High amounts of the metabolites, mainly 8-hydroxy- and, 7-hydroxy-ibafloxacin were excreted in urine and faeces, either unchanged or as glucuronide conjugates. Following oral administration of 15 mg ibafloxacin/kg, the total recovery of ibafloxacin, its metabolites and conjugates in urine and faeces was 61.9-99.9% of the dose within 48 h.
An embedded P2P-based positional audio system in virtual environments (2010)

Networked virtual environments are increasingly used for collaboration tasks and other interactive applications. While the graphics in such virtual worlds are usually three-dimensional, interactive 3D voice support is still in its infancy. Here we describe our demonstration system that supports P2P-based positional audio and interactive voice communication with the SecondLife platform.
Multimedia content processing through cross-modal association (2003)

Multimodal information processing has received considerable attention in recent years. The focus of existing research in this area has been predominantly on the use of fusion technology. In this paper, we suggest that cross-modal association can provide a new set of powerful solutions in this area. We investigate different cross-modal association methods using the linear correlation model. We also introduce a novel method for cross-modal association called Cross-modal Factor Analysis (CFA). Our earlier work on Latent Semantic Indexing (LSI) is extended for applications that use off-line supervised training. As a promising research direction and practical application of cross-modal association, cross-modal information retrieval where queries from one modality are used to search for content in another modality using low-level features is then discussed in detail. Different association methods are tested and compared using the proposed cross-modal retrieval system. All these methods achieve significant dimensionality reduction. Among them CFA gives the best retrieval performance. Finally, this paper addresses the use of cross-modal association to detect talking heads. The CFA method achieves 91.1% detection accuracy, while LSI and Canonical Correlation Analysis (CCA) achieve 66.1% and 73.9% accuracy, respectively. As shown by experiments, cross-modal association provides many useful benefits, such as robust noise resistance and effective feature selection. Compared to CCA and LSI, the proposed CFA shows several advantages in analysis performance and feature usage. Its capability in feature selection and noise resistance also makes CFA a promising tool for many multimedia analysis applications.
Fluorous Metal-Organic Frameworks with Enhanced Stability and High H2/CO2 Storage Capacities (2013)

A new class of metal-organic frameworks (MOFs) has been synthesized by ligand-functionalization strategy. Systematic studies of their adsorption properties were performed at low and high pressure. Importantly, when fluorine was introduced into the framework via the functionalization, both the framework stabilities and adsorption capacities towards H2/CO2 were enhanced significantly. This consequence can be well interpreted by theoretical studies of these MOFs structures. In addition, one of these MOFs TKL-107 was used to fabricate mixed matrix membranes, which exhibit great potential for the application of CO2 separation.
Face Swapping under Large Pose Variations: A 3D Model Based Approach (2012)

Traditional face swapping technologies require the faces of source images and target images have similar pose and appearance (usually frontal). This limits its applications. This paper presents a method for face swapping based on personalized 3D head models. This framework builds a personalized 3D head model from a frontal face and can be rendered at any pose to match the characters in the image we want to swap. The 3D head model is constructed by a user uploaded frontal view face image. This construction process goes through face alignment and feature point matching. The final personalized 3D head is built by deforming a standard 3D head model using radial basis function to match the specific person. To make the synthesized face seamlessly blended into the image, color transfer and multi-resolution spline technique are applied. We use the proposed technique to create personalized storybook where the characters are replaced with a user's face and promising results are obtained. The system can be used in face de-identification as well.