gebhart/patrepeval huggingface dataset:
Best Practices for Nurse Leaders: Succession Planning (2017)

Beverly Fray, PhD, is a PhD candidate at Florida International University, Miami, and Jonas Veterans Scholar. Rose O. Sherman, EdD, RN, FAAN, is a professor of nursing and director of the nursing leadership institute at Florida Atlantic University in Boca Raton, Florida. She serves as Chair of the Leadership Task Force in the Florida Action Coalition on the Future of Nursing. Rose is the Editor in Chief of Nurse Leader, the journal of the American Organization of Nurse Executives. She is also the editor of a popular leadership blog www.emergingrnleader.com Address correspondence to Beverly Fray, PhD, Florida International University, 11200 SW 8th St, Miami, FL 33199 ([email protected]). CM Matters welcomes and invites you to submit articles, stories, practice tips, reflections, and revelations. How has CM changed you and/or how have you affected the lives of others? All inquiries, questions, comments, and manuscripts should be submitted via e-mail to: [email protected] or by mail to Lynn S. Muller, P.O. Box 164, Bergenfield, NJ 07621.Do you have an idea for an article but would like to discuss it? Provide your contact information in an e-mail and you will be contacted by your preferred method.
Critical singularities of the random two-dimensional Ising model (1983)

The critical properties of random ferromagnets with pure specific-heat exponent ${\ensuremath{\alpha}}_{P}=0$ are analyzed using renormalization-group methods. The origin and form of the impurity-induced logarithmic corrections for the random two-dimensional Ising model are discussed. Corrections develop only for the specific heat, which presents a new singularity of the form ${|\mathrm{ln}|T\ensuremath{-}{T}_{c}||}^{1\ensuremath{-}\ensuremath{\mu}}$ as well as a new critical exponent $\ensuremath{\mu}$.
Delcotronic Transistor-Controlled Magnetic Pulse-Type Ignition System (1964)

<div class="htmlview paragraph">Future engine ignition requirements combined with the continued automotive “no service” trend indicated that a new ignition system is desirable for some applications. This paper reviews limitations of present ignition systems and analyzes the Delcotronic ignition system which overcomes these limitations. Recommended applications for the Delcotronic system and the test program by which it was developed are discussed.</div> <div class="htmlview paragraph">It is concluded that the Delcotronic ignition system satisfies the needs of today's special applications and that ignition systems of this type can be built to satisfy the requirements of future engines.</div>
Numerical study on nozzle-field cooling of heated aluminium blanks for hot-stamping (2018)

Nozzle-field cooling is a popular cooling technology which uses a flexible array of low-pressure gas jets to quickly cool down components in a device working in conventional atmosphere. This cooling process is energy saving, free of toxic gases, and it can reduce workpiece distortion during cooling. In this study, nozzle-field cooling is adopted for a potential, fast cooling process for large metal blanks. Numerical simulations were conducted to investigate the performance of a designed cooling tool with different design parameters. In this paper, simulation results are presented, along with several considerations for the nozzle-field cooling system design.
Fine‐needle aspiration biopsy as an adjunct to the diagnosis of a rare adnexal tumor of hair follicle origin: Trichoblastoma (2003)

Fine-needle aspiration biopsy (FNAB) is a technique used increasingly for the investigation of primary and metastatic cutaneous tumors. Trichoblastoma is a rare benign skin appendage tumor of hair germ origin. We report the diagnosis by FNAB of a rare giant subcutaneous tumor, trichoblastoma, from an 81-yr-old woman with a subcutaneous mass in the interscapular area of her back. The cytologic characteristics of the tumor are discussed in detail in this report. The findings have been compared with the histologic features of the tumor after surgical excision. We have characterized several distinctive cytologic features that may aid in the diagnosis of this rare neoplasm. While most reported cases have been diagnosed from surgical excisional biopsy specimens, FNAB may also be a valuable tool for the accurate diagnosis of trichoblastoma in the proper clinical context.
Multi-chip packaging for high speed superconducting circuits (1995)

We report the development of a multi-chip module (MCM) technology using Nb metallization and benzocyclobutene (BCB) polymer dielectric. The Nb/BCB structure displays very low loss, has low processing temperature, and forms a wide range of microstrip transmission line impedances. We are developing flip chip, solder attachment for die mounting. We also report the electrical characterization of Nb/BCB/Nb for both microstrip resonators, delay lines, and bandpass filters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A wireless microsystem for the remote sensing of pressure, temperature, and relative humidity (2005)

This work presents a microsystem that utilizes inductive power and data transfer through a backscatter-modulated carrier and a transducer interface that monitors its environment through embedded capacitive transducers. Formed on a single chip, transducers for temperature, pressure, and relative humidity are realized using a silicon-on-glass process that combines anodic bonding and a silicon-gold eutectic to realize vacuum-sealed cavities with low-impedance (6 /spl Omega/) electrical feedthroughs. Temperature is sensed capacitively using a row of Si/Au bimorph beams that produce a sensitivity of 15 fF//spl deg/C from 20 to 100/spl deg/C. The absolute pressure sensors have a sensitivity of 15 fF/torr and a range from 500 to 1200 torr, while the relative humidity sensor responds with 39 fF/%RH from 20 to 95%RH. A relaxation oscillator implements low-power capacitance-to-frequency conversion on a second chip with a sensitivity of 750 Hz/pF at 10 kHz, forming a 341 /spl mu/W transducer interface. The system is remotely powered by a 3-MHz carrier and has a volume of 32 mm/sup 3/, including the hybrid antenna wound around the perimeter of the system.
Controlled Formation of Isolated Silver Islands for Surface-Enhanced Raman Scattering (2000)

Rough silver surfaces enhance the Raman scattering of adsorbed molecules by many orders of magnitude. The size, shape, and surroundings of the metal particles greatly influence the resulting Raman intensities. With the controlled formation of well-separated silver islands, direct investigation of the local origin of the Raman enhancement is greatly facilitated. We summarize the effects of experimental parameters during and after vapor deposition of silver on the resulting surface morphology. With the selection of suitable experimental conditions, particle sizes and shapes, as well as the interparticle distances, can be controlled so that well-separated silver islands are formed that still show high Raman enhancement. The surfaces were characterized morphologically by means of atomic force microscopy (AFM) and scanning electron microscopy (SEM). Optical characterization was carried out by using ultraviolet-visible and Raman spectroscopy.
Designing Highly Intelligent Unmanned Aerial Vehicle-Borne Software (2012)

The existing software borne by an unmanned aerial vehicle (UAV) is mostly made up of functional modules with a simple design for meeting its functional requirements, thus being unable for the UAV to meet the requirements for its software to be intelligent, integrated and credible. To meet the requirements for the new-type UAV to be functionally varied, highly autonomous and intelligent, we construct the intelligent database and the network-adaptive and real-time middleware so as to greatly enhance the intelligence of the UAV-borne software and the autonomous flight capability of the UAV, paving a firm foundation for enhancing the functional diversity, autonomy and intelligence of the future advanced UAV.
Hysteresis heating for the treatment of tumours (1984)

A method is described whereby, utilising a biocompatible magnetic glass-ceramic material, effective hysteresis heating in living tissue was accomplished. Initial experiments on mice showed that a significant heating effect can be obtained in the ceramic-impregnated regions. An analysis is also given for the projected safe operating field-frequency regime of the hysteresis therapy.
Purification and characterization of E. histolytica antigen for diagnosis of amoebiasis. (1990)

Entamoeba histolytica soluble crude antigen was fractionated by gel filtration on Sephacryl S-300 into four fractions, viz. F1(669 kDa); F2(51.2 kDa); F3(25.1 kDa) and F4(10.5 kDa). F1 fraction was observed to be more sensitive and specific for the detection of antibody in amoebiasis than the crude and other fractions of purified antigens employing IHAT and ELISA. ELISA was found to be better than IHAT since it could detect antibody in the sera (3/6) of asymptomatic cyst passers. The cross reaction of crude antigen with toxocariasis (1/4) and toxoplasmosis (2/5) sera were associated with F4 fraction. F3 and F4 were having low molecular weight and were not sensitive in detection of antibody in amoebiasis. Biochemical characterization revealed glycoprotein nature of the specific (F1) antigen fraction.
Mediators of inflammation and acute phase response in the liver. (2001)

The acute phase response is a generalized response of the organism to multiple disturbances of its physiological homeostasis. It consists of local and systemic reactions. Inflammatory processes are the main causes for the initiation of these defence mechanisms. Responsible mediators for the acute phase response are predominantly cytokines, whereby the liver is the predominant target organ. Changes in hepatocyte gene expression profiles result in dramatic changes in serum concentrations of specific plasma proteins, called acute phase proteins. IL-6 was identified as the principal mediator of this reaction. Via its cellular signal transducer gp130 IL-6 induces DNA-binding of STAT transcription factors on regulatory elements of target genes. While IL-6 dependent processes are mainly conferred to be protective other inflammatory cytokines are attributed to be cytotoxic for the liver. TNF-alpha was shown to be involved in several models of liver failure as a mediator for both cytotoxicity and cell proliferation. TNF-alpha leads via caspases to the onset of apoptosis, the so-called programmed cell death. On the other hand it activates NF-kappaB thereby triggering inflammatory processes. In this review we display the relevance for intracellular actions of both cytokines in several models of liver injury. Especially we refer to the T-cell mediated Concanavalin A induced liver failure and to liver regeneration induced by CCL4 and partial hepatectomy. Both cytokines contribute in concert to a cellular balance during these pathophysiological conditions.
A versatile low-resistance ohmic contact process with ohmic recess and low-temperature annealing for GaN HEMTs (2018)

Deeply recessed ohmic contacts for GaN-based high electron mobility transistors (HEMTs) are demonstrated. It is shown that low-resistance ohmic contacts can be achieved with recessing beyond the AlGaN Schottky barrier where the ohmic contacts are formed on the sidewall of the recess. This makes the process versatile and relatively insensitive to the exact recess depth. The ohmic contact is based on a gold-free metallization scheme consisting of a Ta/Al/Ta metal stack requiring a low-temperature annealing. Important parameters for this type of ohmic contact process include the metal coverage, slope of the etched sidewall, bottom Ta-layer thickness, as well as annealing temperature and duration. The optimized contact resistance is as low as 0.24 Ω mm after annealing at 575 °C. Moreover, this sidewall contact approach was successfully implemented on different epitaxial heterostructures with different AlGaN barrier thickness as well as with and without AlN exclusion layer. All the samples exhibited excellent contact resistances in a wide range of recess depths. The Ta-based, sidewall ohmic contact process is a promising method for forming an ohmic contact on a wide range of GaN HEMT epitaxial designs.
An improved synthesis of S-adenosylhomocysteine and related compounds (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn improved synthesis of S-adenosylhomocysteine and related compoundsKondareddiar Ramalingam and Ronald W. WoodardCite this: J. Org. Chem. 1984, 49, 7, 1291–1293Publication Date (Print):April 1, 1984Publication History Published online1 May 2002Published inissue 1 April 1984https://pubs.acs.org/doi/10.1021/jo00181a036https://doi.org/10.1021/jo00181a036research-articleACS PublicationsRequest reuse permissionsArticle Views324Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Safety Evaluation of Chronic Intrathecal Administration of Idursulfase-IT in Cynomolgus Monkeys (2011)

Recombinant human idursulfase, an intravenous enzyme replacement therapy indicated for treatment of somatic symptoms of mucopolysaccharidosis II (Hunter syndrome), is anticipated to have minimal benefit for the cognitive impairment associated with the severe phenotype. Because intrathecal (IT) administration of enzyme replacement therapy for other lysosomal enzyme disorders has shown efficacy in animal models, an IT formulation of idursulfase (idursulfase-IT) and a drug-delivery device (subcutaneous port connected to a lumbar IT catheter) were developed for treating central nervous system (CNS) involvement. In this chronic safety study, cynomolgus monkeys were dosed weekly with IV idursulfase (0.5 mg/kg) and every four weeks with idursulfase-IT (3, 30, and 100 mg) for six months, with device and vehicle controls treated similarly (n = 6, all groups). Necropsies were performed twenty-four hours post-final IT dose or after a recovery period (four weeks post-final dose in vehicle-control, 3 mg, and 100 mg IT groups: n = 6). No clinical signs or gross central nervous system lesions were observed. Compared to controls, more pronounced cellular infiltrates in brain and spinal cord meninges were noted, which largely resolved after the recovery period. Central nervous sytem levels of idursulfase-IT were dose dependent, as determined by enzyme activity and immunohistochemistry. The no-observed-adverse-effect level of idursulfase-IT was 100 mg.
Near-infrared fluorescent protein iRFP720 is optimal for in vivo fluorescence imaging of rabies virus infection (2017)

In vivo imaging is a noninvasive method that enables real-time monitoring of viral infection dynamics in a small animal, which allows a better understanding of viral pathogenesis. In vivo bioluminescence imaging of virus infection is widely used but, despite its advantage over bioluminescence that no substrate administration is required, fluorescence imaging is not used because of severe autofluorescence. Recently, several far-red and near-infrared (NIR) fluorescent proteins (FPs) have been developed and shown to be useful for whole-body fluorescence imaging. Here, we report comparative testing of far-red and NIR FPs in the imaging of rabies virus (RABV) infection. Using the highly neuroinvasive 1088 strain, we generated recombinant RABV that expressed FPs such as Katushka2S, E2-Crimson, iRFP670 or iRFP720. After intracerebral inoculation to nude mice, the 1088 strain expressing iRFP720, the most red-shifted FP, was detected the earliest with the highest signal-to-noise ratio using a filter set for >700 nm, in which the background signal level was very low. Furthermore, we could also track viral dissemination from the spinal cord to the brain in nude mice after intramuscular inoculation of iRFP720-expressing 1088 into the hind limb. Hence, we conclude that the NIR FP iRFP720 used with a filter set for >700 nm is useful for in vivo fluorescence imaging not only for RABV infection but also for other virus infections. Our findings will also be useful for developing dual-optical imaging of virus-host interaction dynamics using bioluminescence reporter mice for inflammation imaging.
The Portuguese Army in Angola (1969)

War and military institutions have played a crucial part in the history of Angola. Colonial wars, auxiliary armies, expeditions, and soldiergovernors fill the pages of this history, and it is no exaggeration to recall that military expenses have, except for some years during 1930–58, represented the major item in annual budgets since the sixteenth century, when the Portuguese began to conquer the Luanda hinterland. The character and role of the armed forces in Angola, however, have undergone changes: especially since 1961, new developments promise possibly important influences on future events in that territory, events which may not follow traditional patterns in history.
RNA quality in frozen breast cancer samples and the influence on gene expression analysis – a comparison of three evaluation methods using microcapillary electrophoresis traces (2007)

The results indicate that the Manual and RIN methods are superior to the Ratio method for evaluating RNA quality in fresh frozen breast cancer tissues. The objective measurement when using the RIN method is an advantage. Furthermore, the inclusion of samples with degraded RNA may profoundly affect gene expression levels.
4‐Hydroxyacetophenone monooxygenase from <i>Pseudomonas fluorescens</i> ACB (2001)

A novel flavoprotein that catalyses the NADPH-dependent oxidation of 4-hydroxyacetophenone to 4-hydroxyphenyl acetate, was purified to homogeneity from Pseudomonas fluorescens ACB. Characterization of the purified enzyme showed that 4-hydroxyacetophenone monooxygenase (HAPMO) is a homodimer of approximately 140 kDa with each subunit containing a noncovalently bound FAD molecule. HAPMO displays a tight coupling between NADPH oxidation and substrate oxygenation. Besides 4-hydroxyacetophenone a wide range of other acetophenones are readily converted via a Baeyer-Villiger rearrangement reaction into the corresponding phenyl acetates. The P. fluorescens HAPMO gene (hapE) was characterized. It encoded a 640 amino-acid protein with a deduced mass of 71 884 Da. Except for an N-terminal extension of approximately 135 residues, the sequence of HAPMO shares significant similarity with two known types of Baeyer-Villiger monooxygenases: cyclohexanone monooxygenase (27-33% sequence identity) and steroid monooxygenase (33% sequence identity). The HAPMO sequence contains several sequence motifs indicative for the presence of two Rossman fold domains involved in FAD and NADPH binding. The functional role of a recently identified flavoprotein sequence motif (ATG) was explored by site-directed mutagenesis. Replacement of the strictly conserved glycine (G490) resulted in a dramatic effect on catalysis. From a kinetic analysis of the G490A mutant it is concluded that the observed sequence motif serves a structural function which is of importance for NADPH binding.
Investigations on the nature of calcium borogluconate (1938)

Research Article| January 01 1938 Investigations on the nature of calcium borogluconate Herbert Taylor Macpherson; Herbert Taylor Macpherson 1The Moredun Institute, Animal Diseases Research Association, Gilmerton, Midlothian Search for other works by this author on: This Site PubMed Google Scholar James Stewart James Stewart 1The Moredun Institute, Animal Diseases Research Association, Gilmerton, Midlothian Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1938) 32 (1): 76–78. https://doi.org/10.1042/bj0320076 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Herbert Taylor Macpherson, James Stewart; Investigations on the nature of calcium borogluconate. Biochem J 1 January 1938; 32 (1): 76–78. doi: https://doi.org/10.1042/bj0320076 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1938 CAMBRIDGE UNIVERSITY PRESS1938 Article PDF first page preview Close Modal You do not currently have access to this content.
Human mesenchymal stem cells suppress induction of cytotoxic response to alloantigens. (2004)

Mesenchymal stem cells (MSC) fail to induce allogeneic responses in mixed lymphocyte reaction assays. Because MSC express HLA class I molecules, here we investigated whether they could be recognized as allogeneic targets by cytolytic T lymphocytes (CTL). With this aim, CTL precursor (CTLp) frequencies were measured following stimulation of T cells with either allogeneic mononuclear cells (MNC) or MSC originated from the same human bone marrow donor. Lysis of MSC was measured at day 10 of culture in standard chromium release assays. In addition, allogeneic PHA blast T cells or B-EBV lymphoblastoid cell lines (LCLs) generated from the same donor were used as positive controls of lysis. Our results showed that when allogeneic MNC were used to stimulate T cells, a high CTLp frequency was detected towards MSC targets. However, when MSC were used as stimulators, CTLp frequencies were markedly altered whatever the targets used, i.e.: MSC, PHA blast T cells or EBV-B LCLs. Moreover, when graded concentrations of MSC were added together with MNC upon stimulation of alloreactive T cells, we observed a dose-dependent decrease in CTLp frequencies towards MSC targets. This inhibition of MSC lysis was partially overcome by adding exogenous rh-IL-2 from the beginning of cultures. In addition, this suppressive effect was totally reproduced when, instead of MSC, supernatant harvested from MSC cultures was added to allogeneic MNC, upon stimulation of alloreactive T cells. In conclusion, our results demonstrate that MSC which can be recognized as targets by pre-activated alloreactive CTLs, may be able to suppress differentiation of CTL precursors into CTL effectors through secretion of suppressive factors.