gebhart/patrepeval huggingface dataset:
Overexpressed tryptophanyl-tRNA synthetase, an angiostatic protein, enhances oral cancer cell invasiveness (2015)

Oral squamous cell carcinoma (OSCC) is one of the most common neoplasms worldwide. Previously, we identified the angiostatic agent tryptophanyl-tRNA synthetase (TrpRS) as a dysregulated protein in OSCC based on a proteomics approach. Herein, we show that TrpRS is overexpressed in OSCC tissues (139/146, 95.2%) compared with adjacent normal tissues and that TrpRS expression positively correlates with tumor stage, overall TNM stage, perineural invasion and tumor depth. Importantly, the TrpRS levels were significantly higher in tumor cells from metastatic lymph nodes than in corresponding primary tumor cells. TrpRS knockdown or treatment with conditioned media obtained from TrpRS-knockdown cells significantly reduced oral cancer cell viability and invasiveness. TrpRS overexpression promoted cell migration and invasion. In addition, the extracellular addition of TrpRS rescued the invasion ability of TrpRS-knockdown cells. Subcellular fractionation and immunofluorescence staining further revealed that TrpRS was distributed on the cell surface, suggesting that secreted TrpRS promotes OSCC progression via an extrinsic pathway. Collectively, our results demonstrated the clinical significance and a novel role of TrpRS in OSCC.
Loss of the maternal <i>H19</i> gene induces changes in <i>Igf</i> 2 methylation in both cis and trans (1997)

Recent investigations have shown that the maintenance of genomic imprinting of the murine insulin-like growth factor 2 (Igf2) gene involves at least two factors: the DNA (cytosine-5-)-methyltransferase activity, which is required to preserve the paternal specific expression of Igf2, and the H19 gene (lying 90 kb downstream of Igf2 gene), which upon inactivation leads to relaxation of the Igf2 imprint. It is not yet clear how these two factors are related to each other in the process of maintenance of Igf2 imprinting and, in particular, whether the latter is acting through cis elements or whether the H19 RNA itself is involved. By using Southern blots and the bisulfite genomic-sequencing technique, we have investigated the allelic methylation patterns (epigenotypes) of the Igf2 gene in two strains of mouse with distinct deletions of the H19 gene. The results show that maternal transmission of H19 gene deletions leads the maternal allele of Igf2 to adopt the epigenotype of the paternal allele and indicate that this phenomenon is influenced directly or indirectly by the H19 gene expression. More importantly, the bisulfite genomic-sequencing allowed us to show that the methylation pattern of the paternal allele of the Igf2 gene is affected in trans by deletions of the active maternal allele of the H19 gene. Selection during development for the appropriate expression of Igf2, dosage-dependent factors that bind to the Igf2 gene, or methylation transfer between the parental alleles could be involved in this trans effect.
Immobilization of a Catalytically Active Rhodium Complex by Electrostatic Interactions of Multiply Charged Phosphine Ligands with a Soluble Polyelectrolyte and Recovery by Ultrafiltration (2001)

Binding via noncovalent electrostatic interactions of multiply sulfonated phosphine ligands with a soluble polyelectrolyte represents a convenient approach for immobilization of a catalytically active rhodium complex. As a polyelectrolyte, PDADMA-BArF4 (poly(diallyldimethylammonium tetrakis(3,5-bis(trifluoromethyl)phenyl)borate)) can be utilized. The polyelectrolyte-bound catalyst is active for hexene hydroformylation, and it can be recovered and recycled by ultrafiltration.
MHC classes I, II, III antigens study in 70 insulin‐dependent diabetics with associated auto‐immune diseases (1988)

Seventy IDDM patients (insulin-dependent diabetics), 48 females and 22 males, most of them adults at the onset of diabetes, and suffering from at least one other associated autoimmune manifestation (AAM) were studied for HLA A,B,C, DR markers and Bf, C4 complement components. Comparisons were made with 108 normal controls and a series of 287 IDDM patients with juvenile onset (under 25 years) and no patent other autoimmune disease. The increase in frequency of HLA-B8 among IDDM patients with AAM was confirmed (36% versus 20% in controls) (p less than 0.04). The frequency of DR4 among diabetics with AAM (33%) was not significantly different from the normal frequency (27%), and the allelic combination DR3/4 was found in only 13% of IDDM with AAM. Corresponding frequencies in patients with IDDM alone were 66% for DR4 and 34% for DR3/4 (p less than 10(-6) and 10(-3) respectively). These results confirm the heterogeneity of IDDM and support, by genetic arguments, the concept of overlapping entities. The hypothesis of a common background of autoimmunity associated with B8 DR3 can be postulated, while the organ specific target process should be associated with various DR alleles.
Open Fractures in the Hand (1964)

Journal Article Open Fractures in the Hand Get access P S London, M.B.E., F.R.C.S P S London, M.B.E., F.R.C.S Surgeon, The Birmingham Accident Hospital Search for other works by this author on: Oxford Academic Google Scholar Postgraduate Medical Journal, Volume 40, Issue 463, May 1964, Pages 253–261, https://doi.org/10.1136/pgmj.40.463.253 Published: 01 May 1964
For the record: A logical sequence search for S100B target proteins (2000)

The EF-hand calcium-binding protein S100B has been shown to interact in vitro in a calcium-sensitive manner with many substrates. These potential S100B target proteins have been screened for the preservation of a previously identified consensus sequence across species. The results were compared to known structural and in vitro properties of the proteins to rationalize choices for potential binding partners. Our approach uncovered four oligomeric proteins tubulin (alpha and beta), glial fibrillary acidic protein (GFAP), desmin, and vimentin that have conserved regions matching the consensus sequence. In the type III intermediate filament proteins (GFAP, vimentin, and desmin), this region corresponds to a portion of a coiled-coil (helix 2A), the structural element responsible for their assembly. In tubulin, the sequence matches correspond to regions of alpha and beta tubulin found at the alpha beta tubulin interface. In both cases, these consensus sequence matches provide a logical explanation for in vitro observations that S100B is able to inhibit oligomerization of these proteins.
Oriented TiO<sub>2</sub> Nanostructured Pillar Arrays: Synthesis and Characterization (2008)

Nanostructured parallelly oriented TiO2 micropillar arrays, either pure or implanted on a carbon matrix, are prepared via controlled oxidation of hybrid carbonaceous systems. Mild oxidation at 500 °C (O2 1%) leads to formation of parallelly oriented elongated TiO2 pillars, which emerge from a compact α-C phase (TiO2/C composite). Under strong oxidation conditions (O2 10%) formation of pure TiO2 pillar arrays is observed. The pillars constituted of partially cemented anatase or anatase/rutile nanoparticles. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2008/adma200702768_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Hot Isostatic Pressing of a Presintered Yttria‐Stabilized Zirconia Ceramic (1989)

The effect of hot isostatic pressing on the bend strength of ZrO 2 –3 mol% Y 2 O 3 was critically dependent on the presintering process. Optimally sintered bodies contained no open porosity and exhibited large increases in strength following hot isostatic pressing. When open porosity of as little as 0.3% persisted after sintering, hot isostatic pressing increased the bulk density, but little or no increase in strength was realized. Two‐parameter Weibull analysis of the strength data was used to quantify the strength improvement obtained following hot isostatic pressing. Typical fracture‐initiating flaws were identified through optical and electron microscopy.
A Transmission X-ray Microscope (TXM) for Non-destructive 3D Imaging of ICs at Sub-100 nm Resolution (2002)

Abstract Xradia has developed a laboratory table-top transmission x-ray microscope, TXM 54-80, that uses 5.4 keV x-ray radiation to nondestructively image buried submicron structures in integrated circuits with at better than 80 nm 2D resolution. With an integrated tomographic imaging system, a series of x-ray projections through a full IC stack, which may include tens of micrometers of silicon substrate and several layers of Cu interconnects, can be collected and reconstructed to produce a 3D image of the IC structure at 100 nm resolution, thereby allowing the user to detect, localize, and characterize buried defects without having to conduct layer by layer deprocessing and inspection that are typical of conventional destructive failure analysis. In addition to being a powerful tool for both failure analysis and IC process development, the TXM may also facilitate or supplant investigations using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and focused ion beam (FIB) tools, which generally require destructive sample preparation and a vacuum environment.
Towards an Ontology-based Risk Assessment in Collaborative Environment Using the SemanticLIFE (2007)

The rise in interconnectivity in the last few years has made computer systems and networks more vulnerable to threats as they are accessed by an ever increasing number of users. Nowadays organizations are lacking proper security measures and means to calculate risk assessment for their assets. Legacy systems in organizations are facing different kind of risks like viruses, bugs and system failure causing damages to hardware and software resulting in data loss. The ultimate challenge in many organizations is to assess their risk factors for their computers and networks. There is no way to completely overcome the threat that an organization might have. The goal is to calculate risks, so that problems resulting from them could be minimized and to fill the gap between business entities (like a project, a role) and organization infrastructure using semantic Web technologies. SemanticLIFE is a personal information management system which gathers the user interaction events and correlates those by using ontologies. In this paper the ontology-based risk assessment in the context of the organizational security, a fundamental issue for planners and decision makers in the IT field, is explored using SemanticLIFE tool
Development of a Dose-Response Model for SARS Coronavirus (2010)

In order to develop a dose-response model for SARS coronavirus (SARS-CoV), the pooled data sets for infection of transgenic mice susceptible to SARS-CoV and infection of mice with murine hepatitis virus strain 1, which may be a clinically relevant model of SARS, were fit to beta-Poisson and exponential models with the maximum likelihood method. The exponential model (k= 4.1 x l0(2)) could describe the dose-response relationship of the pooled data sets. The beta-Poisson model did not provide a statistically significant improvement in fit. With the exponential model, the infectivity of SARS-CoV was calculated and compared with those of other coronaviruses. The does of SARS-CoV corresponding to 10% and 50% responses (illness) were estimated at 43 and 280 PFU, respectively. Its estimated infectivity was comparable to that of HCoV-229E, known as an agent of human common cold, and also similar to those of some animal coronaviruses belonging to the same genetic group. Moreover, the exponential model was applied to the analysis of the epidemiological data of SARS outbreak that occurred at an apartment complex in Hong Kong in 2003. The estimated dose of SARS-CoV for apartment residents during the outbreak, which was back-calculated from the reported number of cases, ranged from 16 to 160 PFU/person, depending on the floor. The exponential model developed here is the sole dose-response model for SARS-CoV at the present and would enable us to understand the possibility for reemergence of SARS.
Organic-inorganic hybrid tandem multijunction photovoltaics with extended spectral response (2011)

We demonstrate series-connected hybrid tandem multijunction photovoltaics by combining hydrogenated amorphous silicon (a-Si:H) and polymer-based organic photovoltaics (OPVs). To utilize the wide solar spectrum with cost-effective processes, we employed a solution-processed low band gap OPV subcell onto the a-Si:H subcell. The interfacial contact between the subcells strongly affects the photovoltaic performance of the tandem cells. By using MoO3 as an efficient hole transporting intermediate layer instead of the conventional conducting polymer, we obtained power conversion efficiency of 1.84% and open-circuit voltage (VOC) of 1.50 V which corresponds closely to the sum of VOCs of the subcells.
Pseudo-random generators under uniform assumptions (1990)

We prove that given a function f which is oneway in the uniform model (i.e. cannot be inverted except on a vanishing fraction of the inputs by a probabilistic polynomial time Turing machine) it is possible to construct a pseudo random bit-generator which passes all probabilistic polynomial time statistical tests.
Anti-inflammatories in Alzheimer’s disease—potential therapy or spurious correlate? (2020)

Epidemiological evidence suggests non-steroidal anti-inflammatory drugs reduce the risk of Alzheimer's disease. However, clinical trials have found no evidence of non-steroidal anti-inflammatory drug efficacy. This incongruence may be due to the wrong non-steroidal anti-inflammatory drugs being tested in robust clinical trials or the epidemiological findings being caused by confounding factors. Therefore, this study used logistic regression and the innovative approach of negative binomial generalized linear mixed modelling to investigate both prevalence and cognitive decline, respectively, in the Alzheimer's Disease Neuroimaging dataset for each commonly used non-steroidal anti-inflammatory drug and paracetamol. Use of most non-steroidal anti-inflammatories was associated with reduced Alzheimer's disease prevalence yet no effect on cognitive decline was observed. Paracetamol had a similar effect on prevalence to these non-steroidal anti-inflammatory drugs suggesting this association is independent of the anti-inflammatory effects and that previous results may be due to spurious associations. Interestingly, diclofenac use was significantly associated with both reduce incidence and slower cognitive decline warranting further research into the potential therapeutic effects of diclofenac in Alzheimer's disease.
Fundamental Issues in the Geology and Geophysics of Venus (1991)

A number of important and currently unresolved issues in the global geology and geophysics of Venus will be addressable with the radar imaging, altimetry, and gravity measurements now forthcoming from the Magellan mission. Among these are the global volcanic flux and the rate of formation of new crust; the global heat flux and its regional variations; the relative importance of localized hot spots and linear centers of crustal spreading to crustal formation and tectonics; and the planform of mantle convection on Venus and the nature of the interactions among interior convective flow, near-surface deformation and magmatism.
Size Dependence of Inter- and Intracluster Interactions in Core–Shell Iron–Iron Oxide Nanoclusters (2012)

The room-temperature magnetic properties of core–shell iron–iron oxide nanoclusters (NCs) synthesized by a cluster deposition system were investigated, and their dependence on mean cluster size is discussed. In this study, the surface/boundary spins of clusters were not frozen and were thermally activated during the measurements. The intercluster interactions between clusters and intracluster interactions between the iron core (ferromagnetic) and iron oxide shell (ferrimagnetic) were investigated by field-dependent isothermal remanent magnetization and dc demagnetization measurements at room temperature. The Henkel and ΔM plots support the existence of dipolar intercluster interactions that become stronger with the growth of the clusters. The derivative of the initial magnetization curve implies that smaller clusters require lower fields and less time than larger ones to overcome various energy barriers before saturating the moments along the field direction. Coercive field and magnetization were also correlated with the interaction parameters. To compare the room-temperature magnetic results, one system was studied at low temperature, where exchange coupling at the interface between the oxide and metallic phases was observed through bias effect and anisotropy enhancement.
Um percurso para a pesquisa com narrativas orais no norte de Minas Gerais (2008)

In this article we propose to discuss some peculiarities of a research in course with oral narratives produced in the north of Minas Gerais and Vale do Jequitinhonha, starting from a methodological approach that enables the comprehension, through their myths, rites and constituent elements, of the historical-social processes presented in those narratives. Also, enables the comprehension of their systems of representation and identity construction, by means of their memorialistic production. The discussion aims at comprehending the contributions of the Cultural Studies not only for the reconstruction of the subjectivity in the cultural space, but also for the perception of other important axes, such as globalization, migratory processes, culture as social practice and its repercussions on the construction and ressignification of regional identities. Keywords: Oral narrative; memory; identity
The effects of enhanced methionine synthesis on amino acid and anthocyanin content of potato tubers (2008)

Ectopic expression of CgSDelta90 increases the methionine content of tubers, however, results in phenotypic aberrations in potato. Co-expression of the 15-kD beta-zein with CgSDelta90 results in elevation of protein-bound methionine content of tubers, but can not overcome the phenotypical changes caused by CgSDelta90 and can not significantly improve the nutritional value of tubers. The level of PAL mRNA and consequently the amount of anthocyanin pigments are reduced in the CgSDelta90 transgenic tubers suggesting that methionine synthesis and production of anthocyanins is linked.
Dynamic Authentication with Sensory Information for the Access Control Systems (2013)

Access card authentication is critical and essential for many modern access control systems, which have been widely deployed in various government, commercial, and residential environments. However, due to the static identification information exchange among the access cards and access control clients, it is very challenging to fight against access control system breaches due to reasons such as loss, stolen or unauthorized duplications of the access cards. Although advanced biometric authentication methods such as fingerprint and iris identification can further identify the user who is requesting authorization, they incur high system costs and access privileges cannot be transferred among trusted users. In this work, we introduce a dynamic authentication with sensory information for the access control systems. By combining sensory information obtained from onboard sensors on the access cards as well as the original encoded identification information, we are able to effectively tackle the problems such as access card loss, stolen, and duplication. Our solution is backward-compatible with existing access control systems and significantly increases the key spaces for authentication. We theoretically demonstrate the potential key space increases with sensory information of different sensors and empirically demonstrate simple rotations can increase key space by more than 1,000,000 times with an authentication accuracy of 90 percent. We performed extensive simulations under various environment settings and implemented our design on WISP to experimentally verify the system performance.
A clinic-based study of the <i>LRRK2</i> gene in Parkinson disease yields new mutations (2005)

Referral-based studies indicate that a mutation (G2019S) in exon 41 of the LRRK2 gene might be a common cause of Parkinson disease (PD). The authors sequenced leucine-rich repeat kinase 2 (LRRK2) exons 31, 35, and 41 in 371 consecutively recruited patients with PD and found mutations in six (1.6%) subjects, including two heterozygous for new putative pathogenic variants (R1441H, IVS31 + 3A-->G). These data confirm the important contribution of LRRK2 to PD susceptibility in a clinic-based population.
Cyanate Ester Composites Co-Cured with a Silicon-Based Thermal Protection System (2002)

Cyanate esters (CE) have emerged as attractive materials for aerospace applications, due to their ease of processing and excellent high-temperature properties. Using a thermal protection system can increase the service temperature even further. The objective of this research is to develop a co-cure cycle for a cyanate ester/silicon polymer (SM8000) hybrid composite system. The chemorheology and cure kinetics of the CE along with the thermochemical behavior of the SM8000 resin are used to develop a co-cure cycle. Samples prepared by this cure cycle exhibit a 270 'C increase in the onset of thermal decomposition. Interfacial fracture toughness tests reveal a very robust interface, validating the cure cycle.
Amyloidosis-Associated Kidney Disease (2006)

The amyloidoses are a group of disorders in which soluble proteins aggregate and deposit extracellularly in tissues as insoluble fibrils, causing progressive organ dysfunction. The kidney is one of the most frequent sites of amyloid deposition in AL, AA, and several of the hereditary amyloidoses. Amyloid fibril formation begins with the misfolding of an amyloidogenic precursor protein. The misfolded variants self-aggregate in a highly ordered manner, generating protofilaments that interact to form fibrils. The fibrils have a characteristic appearance by electron microscopy and generate birefringence under polarized light when stained with Congo red dye. Advances in elucidating the mechanisms of amyloid fibril formation, tissue deposition, and tissue injury have led to new and more aggressive treatment approaches for these disorders. This article reviews the pathogenesis, diagnosis, clinical manifestations, and treatment of the amyloidoses, focusing heavily on the renal aspects of each of these areas.
Man and Literature (1944)

Man and Literature Man and Literature. By Norman Nicholson. S.C.M. Press, 10s. 6d. Margaret Willy Margaret Willy Search for other works by this author on: Oxford Academic Google Scholar English: Journal of the English Association, Volume 5, Issue 25, Spring 1944, Pages 21–22, https://doi.org/10.1093/english/5.25.21 Published: 01 March 1944