gebhart/patrepeval huggingface dataset:
Kinetics and Relative Rates of the Gallium Bromide Catalyzed Reactions of Alkyl Bromides with Aromatics<sup>1,2</sup> (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics and Relative Rates of the Gallium Bromide Catalyzed Reactions of Alkyl Bromides with Aromatics1,2Charles R. Smoot and Herbert C. BrownCite this: J. Am. Chem. Soc. 1956, 78, 24, 6249–6254Publication Date (Print):December 1, 1956Publication History Published online1 May 2002Published inissue 1 December 1956https://pubs.acs.org/doi/10.1021/ja01605a009https://doi.org/10.1021/ja01605a009research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sensor Detects Semiconductor Escaping From Ampoule (1994)

Electrical resistance and temperature change upon exposure to semiconductors. Sensor detects breakage of ampoule containing molten semiconductor. Chemical reaction between hot semiconductor material and wire causes step increase in electrical resistance and temperature of wire. Step increase in temperature and resistance of sensor indicates presence of hot GaAs. Sensor used to shut down furnace automatically if ampoule breaks and prevents further release of molton semiconductor, which could quickly breach surrounding thin wall of cartridge, damage furnace, and/or release toxic vapors into surrounding area.
Emission mechanisms of bulk GaN and InGaN quantum wells prepared by lateral epitaxial overgrowth (1999)

The emission mechanisms of bulk GaN and InGaN quantum wells (QWs) were studied by comparing their optical properties as a function of threading dislocation (TD) density, which was controlled by lateral epitaxial overgrowth. Slightly improved excitonic photoluminescence (PL) intensity was recognized by reducing TD density from 1010 cm−2 to less than 106 cm−2. However, the major PL decay time was independent of the TD density, but was rather sensitive to the interface quality or material purity. These results suggest that TDs simply reduce the net volume of light-emitting area. This effect is less pronounced in InGaN QWs where carriers are effectively localized at certain quantum disk size potential minima to form quantized excitons before being trapped in nonradiative pathways, resulting in a slow decay time. The absence of any change in the optical properties due to reduction of TD density suggested that the effective band gap fluctuation in InGaN QWs is not related to TDs.
Training with Computer-Supported Motor Imagery in Post-Stroke Rehabilitation (2004)

Converging lines of evidence suggest that motor imagery (the mental simulation of a motor act within working memory) is associated with subliminal activation of the motor system. This observation has led to the hypothesis that cortical activation during motor imagery may affect the acquisition of specific motor skills and help the recovery of motor function. In this paper, we describe a clinical protocol in which we use interactive tools to stimulate motor imagery in hemiplegic stroke patients, thereby helping them to recover lost motor function. The protocol consists of an inpatient and an outpatient phase, combining physical and mental practice. In the inpatient phase, patients are trained in a laboratory setting, using a custom-made interactive workbench (VR Mirror). After discharge, patients use a portable device to guide mental and physical practice in a home setting. The proposed strategy is based on the hypotheses that: (a) combined physical and mental practice can make a cost-effective contribution to the rehabilitation of stroke patients, (b) effective mental practice is not possible without some form of support, from a therapist (as in our inpatient phase) or from technology (as in the outpatient phase), (c) the inclusion of an outpatient phase will allow the patient to practice more often than would otherwise be possible, therefore increasing the speed and/or effectiveness of learning, and (d) the use of interactive technology will reduce the patient's need for skilled support, therefore improving the cost-effectiveness of training.
Discovering novel phenotypes with automatically inferred dynamic models: a partial melanocyte conversion in Xenopus (2017)

Progress in regenerative medicine requires reverse-engineering cellular control networks to infer perturbations with desired systems-level outcomes. Such dynamic models allow phenotypic predictions for novel perturbations to be rapidly assessed in silico. Here, we analyzed a Xenopus model of conversion of melanocytes to a metastatic-like phenotype only previously observed in an all-or-none manner. Prior in vivo genetic and pharmacological experiments showed that individual animals either fully convert or remain normal, at some characteristic frequency after a given perturbation. We developed a Machine Learning method which inferred a model explaining this complex, stochastic all-or-none dataset. We then used this model to ask how a new phenotype could be generated: animals in which only some of the melanocytes converted. Systematically performing in silico perturbations, the model predicted that a combination of altanserin (5HTR2 inhibitor), reserpine (VMAT inhibitor), and VP16-XlCreb1 (constitutively active CREB) would break the all-or-none concordance. Remarkably, applying the predicted combination of three reagents in vivo revealed precisely the expected novel outcome, resulting in partial conversion of melanocytes within individuals. This work demonstrates the capability of automated analysis of dynamic models of signaling networks to discover novel phenotypes and predictively identify specific manipulations that can reach them.
Numbers and Organization of RNA Polymerases, Nascent Transcripts, and Transcription Units in HeLa Nuclei (1998)

Using HeLa cells, we have developed methods to determine 1) the number of RNA polymerases that are active at any moment, 2) the number of transcription sites, and 3) the number of polymerases associated with one transcription unit. To count engaged polymerases, cells were encapsulated in agarose, permeabilized, treated with ribonuclease, and the now-truncated transcripts extended in [32P]uridine triphosphate; then, the number of growing transcripts was calculated from the total number of nucleotides incorporated and the average increment in length of the transcripts. Approximately 15, 000 transcripts were elongated by polymerase I, and approximately 75,000 were elongated by polymerases II and III. Transcription sites were detected after the cells were grown in bromouridine for <2.5 min, after which the resulting bromo-RNA was labeled with gold particles; electron microscopy showed that most extranucleolar transcripts were concentrated in approximately 2400 sites with diameters of approximately 80 nm. The number of polymerases associated with a transcription unit was counted after templates were spread over a large area; most extranucleolar units were associated with one elongating complex. These results suggest that many templates are attached in a "cloud" of loops around a site; each site, or transcription "factory," would contain approximately 30 active polymerases and associated transcripts.
Assessment of Voltage Unbalance (2001)

This paper endeavors to present a comprehensive summary of the causes and effects of voltage unbalance and to discuss related standards, definitions, and mitigation techniques. Several causes of voltage unbalance on the power system and in industrial facilities are presented as well as the resulting adverse effects on the system and on equipment such as induction motors and power electronic converters and drives. Standards addressing voltage unbalance are discussed and clarified, and several mitigation techniques are suggested to correct voltage unbalance problems. This paper makes apparent the importance of identifying potential unbalance problems for the benefit of both the utility and customer.
Target detection with a liquid-crystal-based passive Stokes polarimeter (2004)

We present an imaging system that measures the polarimetric state of the light coming from each point of a scene. This system, which determines the four components of the Stokes vector at each spatial location, is based on a liquid-crystal polarization modulator, which makes it possible to acquire four-dimensional Stokes parameter images at a standard video rate. We show that using such polarimetric images instead of simple intensity images can improve target detection and segmentation performance.
Telemetry, November 2014 (2014)

Inside This Issue:--Message from the Director Events--Shout Out - Brittnie Dotson--Graduate Student Mentor Program--New Faces - Tigstu Woldeyohanns--Shout Out - Vanessa Espinoza--Writing the Personal Statement--Contact Information
PLL-free receiver for Gabor division/spread spectrum system (2013)

Non-coherent signal with unknown delay and Doppler is recovered by Gabor division/spread spectrum system. Separable property (SP) condition for time and frequency synchronization leads us to determine delay and Doppler precisely. This paper gives an enlargement of acceptable delay and Doppler region by using multiple codes and their associated receivers simultaneously without increasing computation time. As its application, two-target simultaneous determination is discussed.
Spectroscopic Studies of the Chan–Lam Amination: A Mechanism-Inspired Solution to Boronic Ester Reactivity (2017)

We report an investigation of the Chan-Lam amination reaction. A combination of spectroscopy, computational modeling, and crystallography has identified the structures of key intermediates and allowed a complete mechanistic description to be presented, including off-cycle inhibitory processes, the source of amine and organoboron reactivity issues, and the origin of competing oxidation/protodeboronation side reactions. Identification of key mechanistic events has allowed the development of a simple solution to these issues: manipulating Cu(I) → Cu(II) oxidation and exploiting three synergistic roles of boric acid has allowed the development of a general catalytic Chan-Lam amination, overcoming long-standing and unsolved amine and organoboron limitations of this valuable transformation.
Total Synthesis and Structural Elucidation of the Antifungal Agent Papulacandin D (1996)

Condensation of the aryllithium reagents, prepared from the bromides 10 and 11 and tert-butyllithium, with lactone 19 and acid-catalyzed spirocyclization gave the papulacandin spiroketals 14 and 15. Subsequent protection using di-tert-butylsilyl bis(trifluoromethanesulfonate) gave the diols 31 and 30. Isoleucine (37) was converted using a double Wittig reaction sequence and propargylation of the intermediate aldehyde 46 into the alkynol 47. Separation of the C-7 epimers of 47 was achieved using kinetic resolution via Sharpless epoxidation. Both alkynol epimers 53 and 57 were converted into the papulacandin side chain esters 65 and 66 using a hydrozirconation and palladium(0)-catalyzed coupling sequence. Comparisons of Mosher ester derivatives of 65 and 66 with the Mosher ester derivative of the natural papulacandin side chain and further degradation were consistent with the stereochemistry of the natural product being 7S,14S. Esterification of the spiroketals with the mixed anhydride 70 and global deprotection gave papulacandin D (1).
Evaluating the effectiveness of model-based power characterization (2011)

Accurate power characterization is important in computing platforms for several reasons ranging from poweraware adaptation to power provisioning. Power characterization is typically obtained through either direct measurements enabled by physical instrumentation or modeling based on hardware performance counters. We show, however, that linear-regression based modeling techniques commonly used in the literature work well only in restricted settings. These techniques frequently exhibit high prediction error in modern computing platforms due to inherent complexities such as multiple cores, hidden device states, and large dynamic power components. Using a comprehensive measurement framework and an extensive set of benchmarks, we consider several more advanced modeling techniques and observe limited improvement. Our quantitative demonstration of the limitations of a variety of modeling techniques highlights the challenges posed by rising hardware complexity and variability and, thus, motivates the need for increased direct measurement of power consumption. 1
Metabolic exploitation of the sialic acid biosynthetic pathway to generate site-specifically labeled antibodies (2013)

Lack of a universal site-specific conjugation methodology for antibodies limits their potential to be developed as tumor-specific imaging agents or targeted therapeutics. A potential mechanism for site-specific conjugation involves utilization of the conserved N-glycosylation site in the CH2 domain. We sought to develop an antibody with an altered azido-sugar at this site whereby site-specific label could be added. The HB8059 hybridoma was cultured with peracetylated N-azidoacetlymannosamine (Ac4ManNAz). The resulting azido-sugar antibody was conjugated to phosphine-polyethylene glycol (PEG3)-biotin via a modified Staudinger reaction. Biochemical and functional characterization of the biotinylated antibody was performed. The azido-sugar antibody was also labeled with DyLight-650-Phosphine and injected into mice harboring pancreatic cancer xenografts. The tumors were dissected and imaged utilizing an IVIS fluorescent camera. The antibody was successfully produced in 100 μM Ac4ManNAz. The biotinylated antibody demonstrated a 50 kDa heavy and 25 kDa light chain on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, but demonstrated a single band at 50 kDa on western blot. Treatment with a N-linked glycosidase extinguished the band. Flow cytometry demonstrated antigen-specific binding of CA19-9-positive cells and the antibody localized to the antigen-positive tumor in vivo. We successfully produced an antibody with an azido-sugar at the conserved CH2 glycosylation site. We were able to utilize this azide to label the antibody with biotin or fluorescent label and demonstrate that the label is added in a site-specific manner to the heavy chain, N-linked glycosylation site. Finally, we demonstrated functionality of our antibody for in vitro and in vivo targeting of pancreatic cancer cells.
Three-Dimensional Abutment System (1991)

The purpose of this chapter is to present a detailed description of the design and implementation of an automated layout system based on the principle of three-dimensional cell tessellation proposed in the previous chapter. The description begins with a statement of the experimental aims and required features of the layout system and continues with details of circuit representation. This is followed by details of the design and implementation of cell and layout representation, and of the abutment algorithms. A number of important properties which abutting layouts must possess are highlighted in the details of the algorithms. Finally, the control of the abutment process is discussed through the construction of merit functions and mechanisms for combining elements of the algorithms.
Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis (2000)

The de novo pathway of sphingolipid synthesis has been identified recently as a novel means of generating ceramide during apoptosis. Furthermore, it has been suggested that the activation of dihydroceramide synthase is responsible for increased ceramide production through this pathway. In this study, accumulation of ceramide mass in Molt-4 human leukemia cells by the chemotherapy agent etoposide was found to occur primarily due to activation of the de novo pathway. However, when the cells were labeled with a substrate for dihydroceramide synthase in the presence of etoposide, there was no corresponding increase in labeled ceramide. Further investigation using a labeled substrate for serine palmitoyltransferase, the rate-limiting enzyme in the pathway, resulted in an accumulation of label in ceramide upon etoposide treatment. This result suggests that the activation of serine palmitoyltransferase is the event responsible for increased ceramide generation during de novo synthesis initiated by etoposide. Importantly, the ceramide generated from de novo synthesis appears to have a distinct function from that induced by sphingomyelinase action in that it is not involved in caspase-induced poly (ADP-ribose)polymerase proteolysis but does play a role in disrupting membrane integrity in this model system. These results implicate serine palmitoyltransferase as the enzyme controlling de novo ceramide synthesis during apoptosis and begin to define a unique function of ceramide generated from this pathway.
Quantitative analysis of the velocity characteristics of optokinetic nystagmus and optokinetic after‐nystagmus (1977)

1. Velocity characteristics of optokinetic nystagmus (OKN) and optokinetic after-nystagmus (OKAN) induced by constant velocity full field rotation were studied in rhesus monkeys. A technique is described for estimating the dominant time constant of slow phase velocity curves and of monotonically changing data. Time constants obtained by this technique were used in formulating a model of the mechanism responsible for producing OKN and OKAN.2. Slow phase velocity of optokinetic nystagmus in response to steps in stimulus velocity was shown to be composed of two components, a rapid rise, followed by a slower rise to a steady-state value. Peak values of OKN slow phase velocity increased linearly with increases in stimulus velocity to 180 degrees /sec. Maximum slow phase eye velocities in the monkey are 2-3 times as great as in humans.3. At the onset of OKAN, slow phase velocity falls by about 10-20%, followed by a slower decline to zero. Peak OKAN slow phase velocities were linearly related to optokinetic stimulus velocities up to 90-120 degrees /sec. Above 120 degrees /sec OKAN slow phase velocity saturated although OKN slow phase velocity continued to increase.4. The charge and discharge characteristics of OKAN were studied. The OKAN mechanism charged in 5-10 sec and discharged over 20-60 sec in darkness. The time constants of decay in OKAN slow phase velocity decreased as stimulus velocities increased. They also decreased on repeated testing. In several monkeys there was a consistent difference in the rate of decay of OKAN slow phase velocity to the right and left.5. Extended visual fixation discharged the activity responsible for producing OKAN. Short fixation times caused only a partial discharge of the OKAN mechanism. Following brief periods of fixation, OKAN resumed but with depressed slow phase velocities.6. A model based on a state realisation of a peak detector was formulated which approximately reproduces the salient characteristics of OKN and OKAN. This model predicts the three dominant characteristics of OKAN: (1) charge over 5-7 sec, (2) slow discharge in darkness, and (3) rapid discharge with visual fixation. With the addition of direct fast forward pathways, it also correctly predicts the rapid and slow rise in OKN. We postulate that OKAN is produced by a central integrator which is also active during OKN. Presumably this integrator acts to maximize velocities during OKN and to smooth and stabilize ocular following during movement of the visual surround.
An intermediate representation for optimizing machine learning pipelines (2019)

Machine learning (ML) pipelines for model training and validation typically include preprocessing, such as data cleaning and feature engineering, prior to training an ML model. Preprocessing combines relational algebra and user-defined functions (UDFs), while model training uses iterations and linear algebra. Current systems are tailored to either of the two. As a consequence, preprocessing and ML steps are optimized in isolation. To enable holistic optimization of ML training pipelines, we present Lara, a declarative domain-specific language for collections and matrices. Lara's inter-mediate representation (IR) reflects on the complete program, i.e., UDFs, control flow, and both data types. Two views on the IR enable diverse optimizations. Monads enable operator pushdown and fusion across type and loop boundaries. Combinators provide the semantics of domain-specific operators and optimize data access and cross-validation of ML algorithms. Our experiments on preprocessing pipelines and selected ML algorithms show the effects of our proposed optimizations on dense and sparse data, which achieve speedups of up to an order of magnitude.
Enhanced Channel Mobility in 4H-SiC MISFETs by Utilizing Deposited SiN/SiO<sub>2</sub> Stack Gate Structures (2008)

Deposited SiN/SiO2 stack gate structures have been investigated to improve the 4H-SiC MOS interface quality. Capacitance-voltage measurements on fabricated SiN/SiO2 stack gate MIS capacitors have indicated that the interface state density is reduced by post-deposition annealing in N2O at 1300°C. The usage of thin SiN and increase in N2O-annealing time lead to a low interface state density of 1×1011 cm-2eV-1 at EC – 0.2 eV. Oxidation of the SiN during N2O annealing has resulted in improvement of SiC MIS interface. The fabricated SiN/SiO2 stack gate MISFETs demonstrate a high channel mobility of 32 cm2/Vs on (0001)Si face and 40 cm2/Vs on (000-1)C face.
SurfelGAN: Synthesizing Realistic Sensor Data for Autonomous Driving (2020)

Autonomous driving system development is critically dependent on the ability to replay complex and diverse traffic scenarios in simulation. In such scenarios, the ability to accurately simulate the vehicle sensors such as cameras, lidar or radar is essential. However, current sensor simulators leverage gaming engines such as Unreal or Unity, requiring manual creation of environments, objects and material properties. Such approaches have limited scalability and fail to produce realistic approximations of camera, lidar, and radar data without significant additional work. In this paper, we present a simple yet effective approach to generate realistic scenario sensor data, based only on a limited amount of lidar and camera data collected by an autonomous vehicle. Our approach uses texture-mapped surfels to efficiently reconstruct the scene from an initial vehicle pass or set of passes, preserving rich information about object 3D geometry and appearance, as well as the scene conditions. We then leverage a SurfelGAN network to reconstruct realistic camera images for novel positions and orientations of the self-driving vehicle and moving objects in the scene. We demonstrate our approach on the Waymo Open Dataset and show that it can synthesize realistic camera data for simulated scenarios. We also create a novel dataset that contains cases in which two self-driving vehicles observe the same scene at the same time. We use this dataset to provide additional evaluation and demonstrate the usefulness of our SurfelGAN model.