gebhart/patrepeval huggingface dataset:
Service communities (2006)

Businesses increasingly provide and use services, applying formal (Web) services technology for the description, composition, and management of software as services. At the same time, social communities are emerging on the Web, applying less formal practices and Web 2.0 technology for the dissemination and aggregation of diverse content. In this paper, we are interested in the combination of these two trends in the form of service communities: social and business communities exchanging services. We discuss applications of service communities and introduce the concept of Service Clubs as a structuring mechanism for communities. Clubs have been specifically designed to support community-based, per-project interaction and composition of services.
Studies on the Synthesis of 5-Acyl-2,4-diaminothiazoles from Amidinothioureas (1986)

1-Alkyl or aryl-3-amidinothioureas with or without substituents on the amidino moiety react with α-haloketones to yield 5-acyl-2,4-diaminothiazoles.
Change of nipple preference between successive offspring in Japanese macaques (1989)

Selective use of nipples among free-ranging infant Japanese macaques (Macaca fuscata) was studied. Each infant held only one of its mother's two nipples in the mouth during an average of 90.9% ± 1.5% (SEM) of total nipple contact time. The next offspring born to the same mother tended to use the nipple that its previous sibling had not used. Maternal behavior did not cause use of one nipple or the other.
Executive Committee (1936)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
A region-level graph labeling approach to motion-based segmentation (2002)

This paper deals with the problem of motion-based segmentation of image sequences. Such partitions are multiple-purpose in dynamic scene analysis. We first extract a spatial texture-based partition using an unsupervised MRF approach. The regions obtained are then grouped according to a motion-based criterion. This grouping process relies on two motion estimation techniques and exploits centextual information between regions. In contrast with clustering techniques, region grouping is formalized as a motion-based graph labeling process, within a Markovian framework. Results on real-world image sequences are shown and validate the proposed method.
Tris(polyoxaalkyl)amines (trident), a new class of solid-liquid phase-transfer catalysts (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTris(polyoxaalkyl)amines (trident), a new class of solid-liquid phase-transfer catalystsGerard SoulaCite this: J. Org. Chem. 1985, 50, 20, 3717–3721Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/jo00220a009https://doi.org/10.1021/jo00220a009research-articleACS PublicationsRequest reuse permissionsArticle Views1174Altmetric-Citations104LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oral Vitamin A in Acne Vulgaris Preliminary Report (1981)

Oral vitamin A (retinol) is generally not considered useful in the treatment of acne vulgaris. We conducted a study which showed that retinol was indeed ineffective at the usual doses of 50,000 to 100,000 IU daily. Retinol was highly efficacious in doses of 300,000 units for women and 400,000 to 500,000 units for men, toxicity was slight and limited mainly to skin (xerosis) and mucous membranes (cheilitis). The danger of hypervitaminosis A in this dosage range has been exaggerated. Retinol is a valuable drug for treating stubborn, severely inflammatory acne vulgaris. It is administered until the disease is brought under control, usually within three to four months. Then the dosage is progressively reduced relying on conventional drugs to keep the disease in abeyance.
A Meta-Analysis of Low-Density Lipoprotein Cholesterol, Non-High-Density Lipoprotein Cholesterol, and Apolipoprotein B as Markers of Cardiovascular Risk (2011)

These results further validate the value of apoB in clinical care.
Sessile Droplet Freezing on Hydrophobic Structured Surfaces under Cold Ambient Conditions (2019)

There have been conflicting reports as to whether surface wettability is effective in the freezing delay enhancement of attached water droplets. It is an important problem in the development of anti-icing surfaces needed for applications, such as aircraft wings and infrastructures. Here, we prepared precooled ambient conditions and surfaces which included smooth, microstructured, and two nanostructured surfaces with hydrophobic coatings to create an environment closer to the actual environment and to avoid frost formation, which enhances wetting transition and nucleation. Static and dynamic wetting characteristics of each surface were investigated as the fundamental properties and the freezing behavior of precooled water droplets were observed. A distinct elongation of the freezing delay time was observed for droplets on nanostructured surfaces which have static contact angles >150°, in contrast to those on smooth and microstructured surfaces. However, the difference in droplet adhesion induced by nanostructures showed a negligible impact on freezing delay. These results indicated that the reduction of the actual contact area between the solid and liquid phases restricted ice nucleus formation.
Local particle deposition patterns may play a key role in the development of lung cancer (2003)

The apparent discrepancy between the reported preferential occurrence of bronchial carcinomas in central bronchial airways and current dose estimates for inhaled particles suggests that experimentally observed local accumulations of particles within bronchial airway bifurcations may play a crucial role in lung cancer induction. Here, we computed three-dimensional particle deposition patterns in lobar-segmental airway bifurcations and quantified the resulting inhomogeneous deposition patterns in terms of deposition enhancement factors, which are defined as the ratio of local to average deposition densities. Our results revealed that a small fraction of epithelial cells located at carinal ridges can receive massive doses that may be even a few hundred times higher than the average dose for the whole airway. This lends further credence to the hypothesis that the apparent site selectivity of neoplastic lesions may indeed be caused by the enhanced deposition of toxic particulate matter at bronchial airway bifurcations.
The Antagonists But Not Partial Agonists of Glucocorticoid Receptor Ligands Show Substantial Side Effect Dissociation (2011)

A synthetic glucocorticoid receptor (GR) ligand with the efficacy of a glucocorticoid, but without the accompanying side effects, would meet an unmet medical need for the treatment of inflammatory diseases. It was hypothesized that a GR ligand that shifted helix 12 in a manner distinct from an agonist and an antagonist would confer a distinct GR conformation, resulting in differential gene expression and, ultimately, dissociation of antiinflammatory activity from side effects. A structural feature expected to interfere with helix 12 was incorporated into a nonsteroidal, tricyclic scaffold to create novel, high-affinity, and selective GR ligands that manifested a dual function in cellular assays, partial but robust agonist activity for inflammatory cytokine inhibition, and full antagonist activity for reporter gene activation. In contrast, analogs not likely to hinder helix 12 exhibited partial agonist activity for reporter gene activation. The requirement of full antagonist activity for substantial side effect dissociation was demonstrated in primary human preadipocytes, hepatocytes, and osteoblasts in which effects on adipogenesis, key genes involved in gluconeogenesis, and genes important for bone formation were examined, respectively. The dissociated GR ligands, despite lacking significant reporter gene activation, weakly recruit a limited number of coactivators such as peroxisomal proliferator-activated receptor-γ coactivator 1α. Transcriptional activation was sensitive to both peroxisomal proliferator-activated receptor-γ coactivator 1α and GR levels, providing a basis for cell-selective modulation of gene expression. The antiinflammatory activity of the dissociated ligands was further demonstrated in mouse models of inflammation. Together these results suggest that these ligands are promising candidates with robust antiinflammatory activity and likely dissociation against glucocorticoid-induced side effects.
Stimuli-Responsive Controlled Drug Release from Magnetic-Sensitive Silica Nanospheres (2009)

A novel method for control burst releasing of drug via a high frequency magnetic field (HFMF) from magnetic-sensitive silica nanospheres was developed. The nanospheres were synthesized by a combination of emulsion and sol-gel process with the particles controlled at about 80 nm in diameter. Under repeated exposures to the high frequency magnetic stimulus, the drug release behaviors showed reproducible slow-to-burst profiles while consecutively applying the magnetic stimulus at 10-min switching time and the release profile restored immediately when the stimulus was removed. By taking this non-contact control-burst method, the magnetic silica nanospheres can be designed to treat the cancer therapy and urgent physiological needs.
Percutaneous suture edge-to-edge repair of the mitral valve (2009)

Percutaneous endovascular suture based cardiac repair is feasible. However, in utilising the current device clinical benefit was limited and the repair not durable. In the future, similar endovascular approaches may enable more complex cardiac repair.
Development of a panchromatic acrylamide-based photopolymer for multicolor reflection holography (2010)

We present the development of a panchromatic acrylamide-based photopolymer (ABP) for holographic recording application. The scattering of the recording medium was characterized by measuring the bidirectional scattering distribution function. The dynamic range in the reflection mode of recording was evaluated by measuring the diffraction efficiencies of the holographic gratings recorded individually at 633 nm, 532 nm, and 473 nm wavelengths at spatial frequencies of 4200 lines/mm, 5000 lines/mm, and 5700 lines/mm, respectively. Spectral characterization of the reflection gratings, recorded using a combined single red-green-blue (RGB) beam, was carried out, and the reconstructed wavelengths were monitored and compared with the recording wavelengths. The recorded and the reconstructed wavelengths were plotted as points on the International Commission on Illumination (CIE) chromaticity diagram in order to reveal shifts due to material shrinkage in the corresponding RGB wavelengths. Finally, reflection holograms of an object were successfully recorded at all the three primary wavelengths. The results represent a strong confirmation that this ABP can be used as a panchromatic recording material and can be employed in future commercial holographic applications.
Further procedures for sequence analysis by computer (1978)

A previous paper(1) described programs for sequence data handling and analysis by computer. The facilities of this basic set are extended by further easily used programs.
The Results of Primary Repair in Acute Injuries of the Posterior Cruciate Ligament (2001)

Background: We analyze the functional evaluation, posterior stability after surgery of acute injuries in the femoral detachment and tibial avulsion fracture of posterior cruciate ligament. Materials and Methods: Twenty two patients who underwent primary repair were followed more than one year after operation (mean follow-up 33.7 months). The patients were evaluated with KT 2000 arthrometer and posterior stress test for posterior stability. Lysholm knee score was used for knee function. Results: Lysholm score revealed 85.3 in femoral detachment group and 91.1 in tibial avulsion fracture group (P
A Hybrid IRF9-STAT2 Protein Recapitulates Interferon-stimulated Gene Expression and Antiviral Response (2003)

Type I interferon (IFN) signaling induces the heterotrimeric transcription complex, IFN-stimulated gene factor (ISGF) 3, which contains STAT1, STAT2, and the DNA binding subunit, interferon regulatory factor (IRF) 9. Because IRF9 is targeted to the nucleus in the absence of IFN stimulation, the potential of IRF9 protein for gene regulation was examined using a GAL4 DNA binding domain fusion system. GAL4-IRF9 was transcriptionally active in reporter gene assays but not in the absence of cellular STAT1 and STAT2. However, the inert IRF9 protein was readily converted to a constitutively active ISGF3-like activator by fusion with the C-terminal transcriptional activation domain of STAT2 or the acidic activation domain of herpesvirus VP16. The IRF9 hybrids are targeted to endogenous ISGF3 target loci and can activate their transcription. Moreover, expression of the IRF9-STAT2 fusion can recapitulate the type I IFN biological response, producing a cellular antiviral state that protects cells from virus-induced cytopathic effects and inhibits virus replication. The antiviral state generated by regulated IRF9-STAT2 hybrid protein expression is independent of autocrine IFN signaling and inhibits both RNA and DNA viruses.
Nafion–Titanate Nanotube Composite Membranes for PEMFC Operating at High Temperature (2007)

Nafion–titanate nanotube composites were investigated as electrolytes for proton exchange membrane fuel cells (PEMFCs) operating at high temperature . With the addition of of nanotubes to the ionomer, PEMFC performance can be significantly sustained for up to . The polarization curves of PEMFCs using the composite electrolytes reflect a competing effect between an increase in water uptake due to the extremely large surface area of the nanotubes and a decrease in proton conductivity of the composites.
Indexcov: fast coverage quality control for whole-genome sequencing (2017)

The BAM and CRAM formats provide a supplementary linear index that facilitates rapid access to sequence alignments in arbitrary genomic regions. Comparing consecutive entries in a BAM or CRAM index allows one to infer the number of alignment records per genomic region for use as an effective proxy of sequence depth in each genomic region. Based on these properties, we have developed indexcov, an efficient estimator of whole-genome sequencing coverage to rapidly identify samples with aberrant coverage profiles, reveal large-scale chromosomal anomalies, recognize potential batch effects, and infer the sex of a sample. Indexcov is available at https://github.com/brentp/goleft under the MIT license.
Peripheral Blood Based Discrimination of Ulcerative Colitis and Crohn’s Disease from Non-IBD Colitis by Genome-Wide Gene Expression Profiling (2011)

A molecular diagnostic assay using easily accessible peripheral blood would greatly assist in the screening and diagnosis of ulcerative colitis (UC) and Crohn’s disease (CD). Transcriptional profiles in blood/biopsy samples from 12 UC (6/12), 9 CD (5/9), 6 non-inflammatory bowel disease (non-IBD) colitis (6/0), and 11 healthy (11/11) patients were assessed by Affymetrix HGU133Plus2.0 microarrays. Prediction analysis of microarrays, discriminant and ROC analyses were performed, the results were validated by RT-PCR and immunohistochemistry using also an independent set of samples (15 blood samples, 45 biopsies). A set of 13 transcripts was differentially expressed in IBD, non-IBD controls and healthy blood samples (100% specificity and sensitivity). Validated difference was found in 16 transcripts between UC, non-IBD and normal blood, and 4 transcripts between CD, non-IBD and normal samples. UC and CD blood cases could be also distinguished by 5 genes with 100% specificity and sensitivity. Some disease associated alterations in blood transcripts were also detected in colonic tissue. IBD subtypes may be discriminated from non-IBD (diverticulitis, infective and ischemic colitis) in vitro from peripheral blood by screening for differential gene expression revealed in this study. Transcriptional profile alterations in peripheral blood can be located in diseased colon.
Environmental Monitoring in Preparation for the Installation of a Green Roof (2014)

Green roofs are becoming an increasingly popular way to improve the environmental, economic, and social performance of both new and existing buildings. Along with the green roofs themselves, it is common in research settings to install sensors that measure various parameters that are important to the operation of the roof, such as energy and water. However, almost all of these monitoring systems are installed at the same time or even after the installation of the green roofs. Therefore, no before-and-after comparisons can be made to quantify some of the green roofs' benefits. To account for this missing data, monitoring equipment was installed on a Purdue University campus building to measure conditions for a year prior to the expected construction of a green roof. This equipment primarily consisted of a weather station to measure rainfall, air temperature and humidity, solar radiation, and wind. Additional sensors measured stormwater runoff, roof temperature, and heat flux. These values were wirelessly recorded every fifteen minutes. Data from the roof validated its expected behavior, with no delay or reduction in water runoff during storm events, and with roof temperature and heat flux heavily dependent on ambient air temperature and solar radiation. This experiment would have then been able to see significant changes in the data once the green roof was installed. Unfortunately, that specific project was cancelled, and the monitoring equipment will be moved to a different campus building as part of a new green roof attempt, but with the advantage this time of having already gained valuable experience.
Theory of Q-Controlled dynamic force microscopy in air (2006)

The theory of dynamic force microscopy in air is developed with respect to the application of the Q-Control technique, which allows to increase or decrease the effective Q factor of the cantilever via an active external feedback. Analytical as well as numerical approaches are applied to solve the equation of motion describing the cantilever dynamics with and without Q-Control in the presence of a model tip-sample interaction force. Based on this analysis, the characteristics of Q-Controlled dynamic force microscopy are compared to conventional dynamic force microscopy carried out in amplitude modulation mode without active Q-Control (“tapping mode”). In the case of negligible tip-sample interaction (i.e., with the tip “far” from the surface), the theory describes how Q-Control alters the shape of the resonance curves of the cantilever by modifying the effective Q factor and shifting the resonance peak. Explicit consideration of tip-sample forces then permits insight into the imaging properties of Q-Controlled dynamic force microscopy. In particular, it is found that an increased Q factor prevents the oscillating cantilever to jump into a repulsive imaging regime during tip-sample approach, which often occurs during conventional tapping mode imaging in air. The analysis reveals in detail which parts of the tip-sample force curve are contributing to the contrast formation for the different imaging conditions if plotted as a function of the tip-sample distance. Based on these findings, we conclude that the restriction of the maximal tip-sample force to specific parts of the attractive regime, which is triggered by the activation of the Q-Control feedback, is the main reason for the enhanced imaging quality reported in several experimental studies if compared to conventional tapping mode imaging without Q-Control.
Biodegradable Bicomponent Fibers from Renewable Sources: Melt‐Spinning of Poly(lactic acid) and Poly[(3‐hydroxybutyrate)<i>‐co‐</i>(3‐hydroxyvalerate)] (2011)

Abstract PHBV is produced by bacteria as intracellular carbon storage. It is advantageous concerning biocompatibility and biodegradability, but its low crystallization rate hinders the melt‐processing of fibers. This problem can be overcome by combining PHBV with PLA in a core/sheath configuration and introducing a new spin pack concept. The resulting PHBV/PLA bicomponent fibers show an ultimate tensile stress of up to 0.34 GPa and an E‐modulus of up to 7.1 GPa. XRD reveals that PLA alone is responsible for tensile strength. In vitro biocompatibility studies with human fibroblasts reveal good cytocompatibility, making these fibers promising candidates for medical therapeutic approaches. magnified image
A Cohort Study of Patient-Reported Outcomes and Healthcare Utilization in Acute Myeloid Leukemia Patients Receiving Active Cancer Therapy in the Last Six Months of Life (2018)

Patients with AML have marked symptoms and QOL impairments that escalate in the final six months of life. Patients entering the healthcare system for active cancer treatment are likely to continue disease-oriented care until death. High rates of hospitalization and blood product transfusion are a direct barrier to transitioning to hospice care.
Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT? (2007)

Myofibroblasts produce and modify the extracellular matrix (ECM), secrete angiogenic and pro-inflammatory factors, and stimulate epithelial cell proliferation and invasion. Myofibroblasts are normally induced transiently during wound healing, but inappropriate induction of myofibroblasts causes organ fibrosis, which greatly enhances the risk of subsequent cancer development. As myofibroblasts are also found in the reactive tumor stroma, the processes involved in their development and activation are an area of active investigation. Emerging evidence suggests that a major source of fibrosis- and tumor-associated myofibroblasts is through transdifferentiation from non-malignant epithelial or epithelial-derived carcinoma cells through epithelial-mesenchymal transition (EMT). This review will focus on the role of EMT in fibrosis, considered in the context of recent studies showing that exposure of epithelial cells to matrix metalloproteinases (MMPs) can lead to increased levels of cellular reactive oxygen species (ROS) that stimulate transdifferentiation to myofibroblast-like cells. As deregulated MMP expression and increased cellular ROS are characteristic of both fibrosis and malignancy, these studies suggest that increased MMP expression may stimulate fibrosis, tumorigenesis, and tumor progression by inducing a specialized EMT in which epithelial cells transdifferentiate into activated myofibroblasts. This connection provides a new perspective on the development of the fibrosis and tumor microenvironments.