gebhart/patrepeval huggingface dataset:
Type-specific collagen degradation by eosinophils (1982)

Despite the association of eosinophils with wound-healing and fibrotic processes, their collagenolytic ability has been poorly defined. By using highly purified eosinophil preparations (greater than 95% eosinophils) obtained from guinea-pigs by peritoneal lavage, we have examined type-specific collagen degradation by eosinophils using sensitive detection methods. The results show that eosinophils contain a metalloprotein that degrades types I and III collagens. This activity was apparent only after the addition of 4-aminophenylmercuric acetate to the reaction mixture, a finding similar to that for latent collagenases described from other sources. No collagenolytic activity against types IV and V collagens could be detected. Thus eosinophils may play a role in the alterations in connective-tissue matrices seen in physiological and pathological states.
Identification of Restricted Subsets of Mature microRNA Abnormally Expressed in Inactive Colonic Mucosa of Patients with Inflammatory Bowel Disease (2010)

Our study supports miRNAs as crucial players in the onset and/or relapse of inflammation from quiescent mucosal tissues in IBD patients. It allows speculating a role for miRNAs as contributors to IBD susceptibility and suggests that some of the miRNA with altered expression in the quiescent mucosa of IBD patients may define miRNA signatures for UC and CD and help develop new diagnostic biomarkers.
Anagrelide: a novel agent for the treatment of myeloproliferative disorders (2000)

Anagrelide hydrochloride (Agrylin, Roberts Pharmaceutical Corp.) is an oral imidazoquinazoline agent that has been shown to reduce elevated platelet counts and the risk of thrombosis in patients with thrombocythaemia in various myeloproliferative disorders (MPD). It is currently approved by the FDA as oral treatment for essential thrombocythaemia (ET) and thrombocythaemia associated with polycythaemia vera (PV). Anagrelide selectively suppresses bone marrow megakaryocytes by interfering with the maturation process and decreasing platelet production without affecting the erythroid and myeloid progenitor cells. Other medications indicated for the treatment of thrombocythaemia, including interferon alpha (IFN-alpha), alkylating agents and hydroxyurea, suppress all cell lines. Anagrelide is known to inhibit platelet cyclic adenosine monophosphate (cAMP) phosphodiesterase at concentrations that exceed those achieved at doses used to treat ET. Anagrelide is extensively metabolised in the liver and its metabolites are primarily excreted in the urine. Adverse effects associated with the use of anagrelide are primarily caused by the drugs' direct vasodilating and positive inotropic effects. These include headache, hypotension and diarrhoea. It has also been known to cause fluid retention, tachycardia, nausea, abdominal pain and arrhythmias. The starting dose of anagrelide ranges from 0.5 mg q.i.d. to 1 mg b.i.d. with a maximum dose of 2.5 mg q.i.d. Adequate responses have been maintained with a median dose of 2-2.5 mg/day. Platelet counts begin to decrease in 7-10 days, however, they return to pre-treatment levels within 4-8 days if therapy is stopped. Anagrelide 2 mg/day for one year costs approximately US$6439, and treatment must continue indefinitely [1].
Web‐based access to the Grid using the Grid Resource Broker portal (2002)

Abstract This paper describes the Grid Resource Broker (GRB) portal, a Web gateway to computational Grids in use at the University of Lecce. The portal allows trusted users seamless access to computational resources and Grid services, providing a friendly computing environment that takes advantage of the underlying Globus Toolkit middleware, enhancing its basic services and capabilities. Copyright © 2002 John Wiley & Sons, Ltd.
Electron diffraction due to a reflection grating in a conducting wire (1997)

We report on quantum transport in the presence of an electron reflection grating fabricated within a high electron mobility transistor structure. The grating was composed of a periodically corrugated potential wall by which the electron waves are diffracted. The low temperature conductance shows a number of peaks with respect to the gate voltage, which are consistent with the electron diffraction effect and are predicted by the Fraunhofer diffraction condition.
Enhancing IHE XDS for Federated Clinical Affinity Domain Support (2007)

One of the key problems in healthcare informatics is the inability to share patient records across enterprises. To address this problem, an important industry initiative called "integrating the healthcare enterprise (IHE)" specified the "cross enterprise document sharing (XDS)" profile. In the IHE XDS, healthcare enterprises that agree to work together form a "clinical affinity domain" and store healthcare documents in an ebXML registry/repository architecture to facilitate their sharing. The affinity domains also agree on a common set of policies such as coding lists to be used to annotate clinical documents in the registry/repository and the common schemes for patient identification. However, since patients expect their records to follow them as they move from one clinical affinity domain to another, there is a need for affinity domains to be federated to enable information exchange. In this paper, we describe how IHE XDS can be enhanced to support federated clinical affinity domains. We demonstrate that federation of affinity domains are facilitated when ontologies, rather than coding term lists, are used to annotate clinical documents. Furthermore, we describe a patient identification protocol that eliminates the need to keep a master patient index file for the federation.
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins (2000)

(-)-Epigallocatechin gallate (EGCG) and theaflavins are believed to be the key active components in tea for the chemoprevention of cancer. However, the molecular mechanisms by which EGCG and theaflavins block carcinogenesis are not clear. In the JB6 mouse epidermal cell line a tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), which causes cell transformation at high frequency, markedly induced NF-kappaB activation. We found that EGCG and theaflavins inhibited TPA-induced NF-kappaB activity in a concentration-dependent manner. These polyphenols blocked TPA-induced phosphorylation of IkappaBalpha at Ser32 in the same concentration range. Moreover, the NF-kappaB sequence-specific DNA-binding activity induced by TPA was also inhibited by these polyphenols. These results suggest that inhibition of NF-kappaB activation is also important in accounting for the anti-tumor promotion effects of EGCG and theaflavins.
Content oriented relations between text units---a structural model for hypertexts (1987)

A common feature of various recently developed information systems is the decomposition of linear document structures which are enforced by conventional print media. Instead, a network organization of information units of different forms (textual, graphical, pictorial and even auditive presentation modes may be combined) is provided. Documents organized this way are called “hypertexts”. However, two questions arise immediately when an effort is made to build information systems on the basis of this conception:
Light-Induced Enantioselective Hydrogenation Using Chiral Derivatives of Casey’s Iron–Cyclopentadienone Catalyst (2011)

We herein report the first example of an asymmetric ketone hydrogenation using chirally modified derivatives of the homogeneous iron(II)–cyclopentadienone–tricarbonyl system, known as Casey’s catalyst. For the synthesis of the chirally modified catalysts, one of three carbonyl ligands was exchanged for a chiral phosphoramidite. To this end, either oxidative decarbonylation using trimethylamine-N-oxide or photolysis was applied. Photolysis was also used to convert the tricarbonyl iron precatalyst (and, analogously, the dicarbonyl phosphoramidite complexes) to the coordinatively unsaturated dicarbonyl (monocarbonyl, respectively) complexes, which are intermediates in the catalytic cycle of ketone hydrogenation. Hydrogen uptake by the latter species affords the “loaded” hydride, as evidenced by 1H NMR spectroscopy. Thus, the preparation of sensitive iron hydrides by the typically low-yielding Hieber reaction could be avoided. Instead, the catalytic cycle is accessed from air-stable carbonyl precursors. In the hydridic form of the phosphoramidite–carbonyl catalysts, the iron atom itself becomes a stereocenter. NMR spectroscopy confirmed the generation of two hydride diastereomers. With the MonoPhos iron dicarbonyl complex, moderate enantioselectivity (up to 31% ee) was achieved in the hydrogenation of acetophenone.
Zoonoses and communicable diseases common to man and animals (1980)

Zoonoses and communicable diseases common to man and animals , Zoonoses and communicable diseases common to man and animals , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
New mutations in protein kinase Cγ associated with spinocerebellar ataxia type 14 (2005)

Autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurological disorders. Point mutations in the gene encoding protein kinase Cgamma (PRKCG) are responsible for spinocerebellar ataxia 14 (SCA14). We screened for mutations in the PRKCG gene, in a large series of 284 ADCA index cases, mostly French (n=204) and German (n=48), in whom CAG repeat expansions in the known SCA genes were previously excluded. Six mutations were found that segregated with the disease and were not detected on 560 control chromosomes, including F643L (exon 18), already reported in another French kindred. Five new missense mutations were identified in exons 4 (C114Y/G123R/G123E), 10 (G360S) and 18 (V692G). All but one (V692G) were located in highly conserved regions of the regulatory or catalytic domains of the protein. All six SCA14 families were French and there was no evidence of reduced penetrance. The phenotype consisted in a very slowly progressive cerebellar ataxia with a mean age at onset of 33.5+/-14.2 years (range 15 to 60 years), occasionally associated with executive dysfunction, myoclonus, myorythmia, tremor or decreased vibration sense. SCA14 represented only 1.5% (7/454) of French ADCA families but none of the German families. It should, however, be considered in patients with slowly progressive ADCA, particularly when myoclonus and cognitive impairment are present.
The effect of Travase on heat-injured skin. (1975)

When applied topically and compared to its placebo experimentally in guinea pigs, Travase was associated with no damage to the epithelium of normal skin, slight damage to that of mechanically injuried (donor-site) skin, and total destruction of all the epithelium in skin subjected to severe but otherwise reversible burn injury. While not preventing this destruction of heat-injured epithelium by Travase, simultaneous use of topical silver sulfadiazine cream did reduce the weight loss and purulence associated with Travase therapy of burns. To evaluate the safety of any form of topical burn therapy satisfactorily, preclinical testing should consider its effects on (1) uninjured skin, (2) skin reversibly injured by heat, and (3) skin immediately coagulated (irreversibly injured) by heat.
Pneumocystis carinii pneumonia in HIV infected patients from South Africa. (1999)

Pneumocystis carinii pneumonia should be considered in the diagnosis of HIV-infected African patients with pulmonary disease whose sputum smears for tuberculosis are negative.
Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma (2014)

NCT00112502.
Detection of Intracranial Internal Carotid Artery and Middle Cerebral Artery Vasospasm Following Subarachnoid Hemorrhage (1996)

Little is known about the accuracy of transcranial Doppler (TCD) sonography in detecting intracranial internal carotid artery (IICA) and middle cerebral artery (MCA) vasospasm. TCD was performed in 49 patients with subarachnoid hemorrhage to evaluate 90 IICAs and 87 MCAs during the vasospasm period. When a mean velocity of at least 90 cm/sec was used to indicate IICA vasospasm, there were 11 positive, 42 negative, 4 false-positive, and 33 false-negative results. Sensitivity was 25% and specificity was 93%. When a mean velocity of at least 120 cm/sec was used to indicate MCA vasospasm, there were 15 positive, 45 negative, 3 false-positive, and 24 false-negative results (15 operator errors). Sensitivity was 38.5% and specificity was 93.7%. When the diagnostic criterion was changed to at least 130 cm/sec, specificities were 100% (IICA) and 96% (MCA) and positive predictive values were 100% (IICA) and 87% (MCA). The authors conclude that TCD accurately detects IICA and MCA vasospasm when flow velocities are at least 130 cm/sec. However, its sensitivity may be underestimated and the importance of operator error, overestimated.
Relative Leaching and Aquatic Toxicity of Pressure-Treated Wood Products Using Batch Leaching Tests (2004)

Size-reduced samples of southern yellow pine dimensional lumber, each treated with one of five different waterborne chemical preservatives, were leached using 18-h batch leaching tests. The wood preservatives included chromated copper arsenate (CCA), alkaline copper quaternary, copper boron azole, copper citrate, and copper dimethyldithiocarbamate. An unpreserved wood sample was tested as well. The batch leaching tests followed methodology prescribed in the U.S. Environmental Protection Agency toxicity characteristic leaching procedure (TCLP). The wood samples were first size-reduced and then leached using four different leaching solutions (synthetic landfill leachate, synthetic rainwater, deionized water, and synthetic seawater). CCA-treated wood leached greater concentrations of arsenic and copper relative to chromium, with copper leaching more with the TCLP and synthetic seawater. Copper leached at greater concentrations from the arsenic-free preservatives relative to CCA. Arsenic leached from CCA-treated wood at concentrations above the U.S. federal toxicity characteristic limit (5 mg/L). All of the arsenic-free alternatives displayed a greater degree of aquatic toxicity compared to CCA. Invertebrate and algal assays were more sensitive than Microtox. Examination of the relative leaching of the preservative compounds indicated that the arsenic-free preservatives were advantageous over CCA with respect to waste disposal and soil contamination issues but potentially posed a greater risk to aquatic ecosystems.
Differential Activation of the Phosphatidylinositol 3′-Kinase/Akt Survival Pathway by Ionizing Radiation in Tumor and Primary Endothelial Cells (2004)

Ionizing radiation induces an intracellular stress response via activation of the phosphatidylinositol 3'-kinase (PI3K)/Akt survival pathway. In tumor cells, the PI3K/Akt pathway is induced through activation of members of ErbB receptor tyrosine kinases. Here, we investigated the receptor dependence of radiation-induced PI3K/Akt activation in tumor cells and in endothelial cells. The integrity of both the ErbB and the vascular endothelial growth factor (VEGF) ligand-activated PI3K/Akt pathway in endothelial cells was demonstrated using specific ErbB and VEGF receptor tyrosine kinase inhibitors. Irradiation of endothelial cells resulted in protein kinase B (PKB)/Akt activation in a similar time course as observed in response to VEGF. More importantly, radiation-induced PKB/Akt phosphorylation in endothelial cells was strongly down-regulated by the VEGF receptor tyrosine kinase inhibitor, whereas the ErbB receptor tyrosine kinase inhibitor did not affect PKB/Akt stimulation in response to irradiation. An opposite receptor dependence for radiation-induced PKB/Akt phosphorylation was observed in ErbB receptor-overexpressing A431 tumor cells. Furthermore, direct VEGF receptor phosphorylation was detected after irradiation in endothelial cells in absence of VEGF, which was almost completely inhibited after irradiation in presence of the VEGF receptor tyrosine kinase inhibitor. These data demonstrate that ionizing radiation induces VEGF ligand-independent but VEGF receptor-dependent PKB/Akt activation in endothelial cells and that PI3K/Akt pathway activation by radiation occurs in a differential cell type and receptor-dependent pattern.
Quantitative measurements of apoptotic cell properties using acoustic microscopy (2010)

Time-resolved acoustic microscopy was used to measure properties of cells such as the thickness, sound velocity, acoustic impedance, density, bulk modulus, and attenuation, before and after apoptosis. A total of 12 cells were measured, 5 apoptotic and 7 non-apoptotic. Measurements made at 375 MHz showed a statistically significant increase in the cell thickness from 13.6 ± 3.1 μm to 17.3 ± 1.6 μm, and in the attenuation from 1.08 ± 0.21 dB/cm/MHz to 1.74 ± 0.36 dB/cm/MHz. The other parameters, such as the sound velocity, density, acoustic impedance, and bulk modulus remained similar within experimental error. Acoustic images obtained at 1.0 GHz showed increased RF-signal backscatter and a clear delineation of the nucleus and cytoplasm from apoptotic cells compared with non-apoptotic cells. Extensive activity was observed optically and acoustically within apoptotic cells. Acoustic measurements made one minute apart showed variations in the ultrasonic backscatter but not attenuation in the cells, which indicated rapid structural changes were occurring but not changes in bulk composition. The normalized crosscorrelation coefficient was used to quantify the variations in the backscatter RF-signal during apoptosis by comparing the first RF signal measured to each successive RF signal every 10 s. A coefficient of 1 indicates strong correlation, whereas a coefficient of 0 indicates no correlation. An average correlation coefficient of 0.93 ± 0.05 was measured for non-apoptotic cells, compared with 0.68 ± 0.17 for apoptotic cells, indicating that the RF signal as a function of time varied rapidly during apoptosis.
Template adaptation in an isolated word-recognition system (1989)

A template-based isolated word-recognition system, with adaptation of templates by weighted averaging with recognised input utterances, is described. Experiments with adaptation of speaker-specific and speaker-independent templates are reported. The results show substantial improvements in the recognition accuracies attained, and reveal the importance of applying compensation technique which adjusts the word distances obtained according to the amounts of adaptation applied. Aspects of interaction between the system and the user are discussed.
Fusion Based Holistic Road Scene Understanding (2014)

This paper addresses the problem of holistic road scene understanding based on the integration of visual and range data. To achieve the grand goal, we propose an approach that jointly tackles object-level image segmentation and semantic region labeling within a conditional random field (CRF) framework. Specifically, we first generate semantic object hypotheses by clustering 3D points, learning their prior appearance models, and using a deep learning method for reasoning their semantic categories. The learned priors, together with spatial and geometric contexts, are incorporated in CRF. With this formulation, visual and range data are fused thoroughly, and moreover, the coupled segmentation and semantic labeling problem can be inferred via Graph Cuts. Our approach is validated on the challenging KITTI dataset that contains diverse complicated road scenarios. Both quantitative and qualitative evaluations demonstrate its effectiveness.
Functional expression of NADPH oxidase components (alpha- and beta-subunits of cytochrome b558 and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cells. (1991)

Recently, we have shown that human glomerular mesangial cells (HMCs) release oxygen radicals from the plasma membrane in response to cytokines. Now we have used diphenylene iodonium, a covalent binding inhibitor of activated 45-kDa flavoprotein, in neutrophils radiolabeled with 125I and could identify a 45-kDa protein band in a separated HMC plasma membrane fraction. Low temperature difference spectroscopy showed a peak absorbance at 428 and 558 nm. Direct potentiometry of HMC membranes (-340 to -160 mV) showed the presence of a low potential cytochrome (76 pmol/mg to HMC membrane protein) identified as cytochrome b558. In slot blots, mouse monoclonal antibody (mAb) 7D5, specific for the extracellular domain of the alpha-subunit, showed a positive reaction with HMCs. In Western blots, mAb 449, directed against the cytoplasmic epitope of the alpha-subunit, identified a 23-kDa protein; and mAb 48, raised against the large (beta) subunit of cytochrome b558 of human neutrophils (Verhoeven, A. J., Bolscher, B. G. J. M., Meerhof, L. J., van Zwieten, R., Keijer, J., Weening, R. S., and Roos, D. (1989) Blood 73, 1686-1694), detected a smear between 75 and 100 kDa in denatured HMC membrane protein. These data determined with HMCs, suggest for the first time the expression of three essential components of NADPH:O2- oxidoreductase in mesenchymal cells.
Anomalous Reaction of Epichlorohydrin with Trimethylamine (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnomalous Reaction of Epichlorohydrin with TrimethylamineD. M. BurnessCite this: J. Org. Chem. 1964, 29, 7, 1862–1864Publication Date (Print):July 1, 1964Publication History Published online1 May 2002Published inissue 1 July 1964https://pubs.acs.org/doi/10.1021/jo01030a047https://doi.org/10.1021/jo01030a047research-articleACS PublicationsRequest reuse permissionsArticle Views777Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts