gebhart/patrepeval huggingface dataset:
Transition Metal Complexes of a Constrained Phosphite Ester. III. Metal Carbonyl Complexes of 4-Methyl-2,6,7-trioxa-l-phosphabicyclo [2.2.2]octane (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransition Metal Complexes of a Constrained Phosphite Ester. III. Metal Carbonyl Complexes of 4-Methyl-2,6,7-trioxa-l-phosphabicyclo [2.2.2]octaneJ. G. Verkade, R. E. McCarley, D. G. Hendricker, and Roy W. KingCite this: Inorg. Chem. 1965, 4, 2, 228–231Publication Date (Print):February 1, 1965Publication History Published online1 May 2002Published inissue 1 February 1965https://doi.org/10.1021/ic50024a022Request reuse permissionsArticle Views134Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (517 KB) Get e-Alertsclose Get e-Alerts
S 27. Aspergillic acid. Part I (1949)

G. Dunn, J. J. Gallagher, G. T. Newbold and F. S. Spring, J. Chem. Soc., 1949, S126 DOI: 10.1039/JR949000S126
Elastic and plastic properties of GaN determined by nano-indentation of bulk crystal (1999)

The major obstacle to the production of a blue laser is posed by difficulties with the preparation of defect-free GaN layers. A considerable amount of empirical work is presently being undertaken to achieve this goal. However, there is a lack of basic research on the reduction of residual stress and defects in these epilayers since the mechanical characteristics of GaN have not been measured yet. This is due to difficulties with experimental examination of thin films. This work addresses the mechanical properties of bulk GaN obtained by a high-pressure method. Young’s modulus (295 GPa), hardness (20 GPa), yield strength (15 GPa), and the stress–strain curve of GaN have been evaluated using nano-indentation. The cause of the sudden depth excursions during indentation of GaN epilayers has been clarified.
Synthesis and Structure−Activity Relationships of a Novel Series of Tricyclic Dihydropyridine-Based K<sub>ATP</sub> Openers That Potently Inhibit Bladder Contractions in Vitro (2004)

Structure-activity relationships were investigated on a novel series of tricyclic dihydropyridine-containing K(ATP) openers. This diverse group of analogues, comprising a variety of heterocyclic rings fused to the dihydropyridine nucleus, was designed to determine the influence on activity of hydrogen-bond-donating and -accepting groups and their stereochemical disposition. Compounds were evaluated for K(ATP) activity in guinea pig bladder cells using a fluorescence-based membrane potential assay and in a pig bladder strip assay. The inhibition of spontaneous bladder contractions in vitro was also examined for a subset of compounds. All compounds studied showed greater potency to inhibit spontaneous bladder contractions relative to their potencies to inhibit contractions elicited by electrical stimulation.
Thioredoxin Mediates Oxidation-Dependent Phosphorylation of CRMP2 and Growth Cone Collapse (2011)

Semaphorin3A (Sema3A) is a repulsive guidance molecule for axons, which acts by inducing growth cone collapse through phosphorylation of CRMP2 (collapsin response mediator protein 2). Here, we show a role for CRMP2 oxidation and thioredoxin (TRX) in the regulation of CRMP2 phosphorylation and growth cone collapse. Sema3A stimulation generated hydrogen peroxide (H2O2) through MICAL (molecule interacting with CasL) and oxidized CRMP2, enabling it to form a disulfide-linked homodimer through cysteine-504. Oxidized CRMP2 then formed a transient disulfide-linked complex with TRX, which stimulated CRMP2 phosphorylation by glycogen synthase kinase-3, leading to growth cone collapse. We also reconstituted oxidation-dependent phosphorylation of CRMP2 in vitro, using a limited set of purified proteins. Our results not only clarify the importance of H2O2 and CRMP2 oxidation in Sema3A-induced growth cone collapse but also indicate an unappreciated role for TRX in linking CRMP2 oxidation to phosphorylation.
NAVIGATION PERFORMANCE IN HIGH EARTH ORBITS USING NAVIGATOR GPS RECEIVER (2006)

NASA GSFC has developed a GPS receiver that can acquire and track GPS signals with sensitivity significantly lower than conventional GPS receivers. This opens up the possibility of using GPS based navigation for missions in high altitude orbit, such as Geostationary Operational Environmental Satellites (GOES) in a geostationary orbit, and the Magnetospheric MultiScale (MMS) Mission, in highly eccentric orbits extending to 12 Earth radii and higher. Indeed much research has been performed to study the feasibility of using GPS navigation in high Earth orbits and the performance achievable. Recently, GSFC has conducted a series of hardware in-the-loop tests to assess the performance of this new GPS receiver in various high Earth orbits of interest. Tracking GPS signals to down to approximately 22-25 dB-Hz, including signals from the GPS transmitter side-lobes, steady-state navigation performance in a geostationary orbit is on the order of 10 meters. This paper presents the results of these tests, as well as sensitivity analysis to such factors as ionosphere masks, use of GPS side-lobe signals, and GPS receiver sensitivity.
Real-time robot drive control with PM-synchronous motors using a DSP-based computer system (2002)

This paper is concerned with robust vector control of a driving system with PM-synchronous servomotor using a fixed-point DSP based computing architecture. Speed and position control systems are analyzed for different operation conditions, control strategies, different PWM type converters and more classes of controllers. A hardware architecture was developed based on a TMS320C5x fixed-point processor, a PWM control unit realized in FPGA technology, an interfacing unit to the incremental encoder and A/D converters for the stator-phase current inputs, a high speed TDM-type serial bus and an emulating and debugging driver. The software was written in both, DSP-assembler language for acquisition and communication programs and in C language for the control algorithm computation. The experimental results clearly illustrate the high performance of the control system we presented in the paper. The computing system solution based on a minimal hardware configuration offers a flexible solution for different control strategies applied to a large scale of driving systems with AC machines.
Addition of hTNF alpha potentiates cytotoxicity of taxol in human ovarian cancer lines. (1995)

Some reports indicate that the cytotoxic activity of hTNFa and taxol might be enhanced when combined with certain chemotherapeutic agents. To assess if taxol might modulate the action of hTNF alpha, we have studied the cytotoxic action of hTNF alpha in combination with taxol on two ovarian carcinoma cell lines, the SKOV3 and SKVLB. These two cell lines are resistant to the action of hTNF alpha. The SKVLB cells overexpressed the multidrug resistant gene (MDR-1) which confers a resistance to taxol. We observed that the combination of low concentration of hTNF alpha with taxol could increase the cytotoxic activity of taxol in SKOV3 cells. Furthermore, a four-hour pretreatment with taxol before adding hTNF alpha to the culture has shown a significant increase in their cytotoxic activity. This increase was not observed at the same level in SKOV3 cells pretreated with hTNF alpha. However, the phenomena was not observed in SKVLB cells. This indicates that taxol could alter the mechanism of hTNF alpha-resistance.
Active Countermeasure Using EMI Honeypot against TEMPEST Eavesdropping in High-Speed Signalling (2018)

Current development in TEMPEST and other eavesdropping strategies becomes a critical threat to the information security. To enhance the countermeasures of eavesdropping the electromagnetic radiation leakage in high-speed signalling such as computer monitors and other high-speed peripherals, this paper proposed an active countermeasure solution by interfering the TEMPEST receiver with a honeypot radiation source. Instead of passive noise jamming methods, this honeypot strategy used the multi-carrier modulation to hide the leakage and transmit a pseudo high -speed signal blended with information baits which may lead the eavesdropper uncovered. This system was implemented on a software defined radio platform and verified to be a prospecting application in future information security.
[Prevalence of HCV and HBV infection in patients with primary hepatocellular carcinoma in Shanxi Province]. (1999)

It suggested that both HCV and HBV infection were main etiologic factors for PHC in local. HBV also was an important factor in the pathogenecity of PHC, especially in those with both positive for HBsAg and anti-HBc. Coinfection with HBV and HCV had an additive effect on PHC pathogenecity.
Incremental versus adjoint models for network sensitivity analysis (1974)

An alternative to the sensitivity analysis of variable parameter networks based on the adjoint model is developed by introduction of the "incremental" model. The latter consists of a network having current and voltage distributions equal to the incrementals of the corresponding distributions of the original network, and may be considered an extension of the familiar case of small-signal analysis of nonlinear networks. Examples of application, as well as extensions to higher order incrementals, are discussed.
Discussion : « Analogy » is Analogous (1966)

On the meaning of " Analogy is Analogical " *
The Influence of Magnesium on Visual Field and Peripheral Vasospasm in Glaucoma (1995)

Previous studies indicated calcium channel blockers to be of some help for normal-tension glaucoma patients. The present study evaluates the effect of magnesium, a 'physiological calcium blocker', in 10 glaucoma patients (6 with primary open-angle glaucoma, 4 with normal-tension glaucoma). All patients had a digital cold-induced vasospasm. Magnesium (121.5 mg) was administered twice a day for a month. After 4 weeks of treatment, the visual fields tended to improve. All three video-nailfold-capillaroscopic parameters [blood cell velocity (in mm/s) before and after cooling, cold-induced blood flow cessation (in seconds) as well as the number of capillaries per microscopic field which showed such a blood flow cessation] as well as digital temperature improved significantly. Systemic blood pressure and pulse rate remained stable. In conclusion, magnesium improves the peripheral circulation and seems to have a beneficial effect on the visual field in glaucoma patients with vasospasm.
A New Sympathovagal Balance Index from Electrodermal Activity and Instantaneous Vagal Dynamics: A Preliminary Cold Pressor Study (2018)

Sympathovagal balance, an autonomic index resulting from the sympathetic and parasympathetic influences on cardiovascular control, has been extensively used in the research practice. The current assessment is based on analyzing Heart Rate Variability (HRV) series in the frequency domain by regarding the ratio between the low and high frequency components (LF/HF). Nevertheless, LF and HF powers are known to be both influenced by vagal activity which strongly bias the accuracy of this method. To this extent, in this study we combine time-varying estimates from electrodermal activity (EDA) and HRV to propose a novel index of sympathovagal balance. Particularly, sympathetic activity is estimated from the EDA power calculated within the 0.045-0.25Hz bandwidth $(EDA_{Symp})$, whereas parasympathetic dynamics is measured instantaneously through a point-process modeling framework devised for heartbeat dynamics $(HF_{pp})$. We test our new index $SV = EDA_{Symp/HF_{pp}}$ on data gathered from 22 healthy subjects (7 females and 15 males) undergoing a 3 minutes gold standard protocol for sympathetic elicitation as the cold-pressor test (CPT). Results show that the activation of the proposed sympathovagal tone is consistent with CPT elicitation and is associated with a significantly higher statistical discriminant power than the standard LF/HF ratio, also revealing different dynamics between female and male subjects.
The Nutritional Value of Five Species of Microalgae for Spat of the Silver-Lip Pearl Oyster, Pinctada maxima (Jameson) (Mollusca: Pteriidae) (1997)

A feeding trial was conducted to assess the nutritional value of five monospecific microalgal diets for spat of the silver-lip (or gold-lip} pearl oyster, Pinctada maxima. The five species tested were Isochrysis aff. galbana (T-ISO), Pavlova lutheri, Chaetoceros muelleri, Chaetoceros calcitrans and Tetraselmis suecica. Spat were 75-d old at the start of the growth trial which ran for 21 d. Pearl oyster spat fed C. muelleri showed the largest increase in ash-free dry weight (organic content}, which was significantly greater (P<0.05) than for any other species. The mean ash-free dry weight (AFDW) of spat fed T. suecica and T-1SO did not differ significantly from each other, but were significantly greater than for spat fed C. calcitrans and P. lutheri (P<0.05). The final AFDW of spat fed P. lutheri was not significantly different from that of unfed spat (P>0.05). Differences in the food value of the five species of algae could not be explained by their reported nutrient composition alone. The results illustrate the importance of experimental testing of algal diets for bivalve spat rather than sole reliance on published nutritional values.
The Inhibiting Action of Minute Amounts of Sodium Hexametaphosphate on the Precipitation of Calcium Carbonate from Ammoniacal Solutions. II. Mechanism of the Process, with Special Reference to the Formation of Calcium Carbonate Crystals. (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Inhibiting Action of Minute Amounts of Sodium Hexametaphosphate on the Precipitation of Calcium Carbonate from Ammoniacal Solutions. II. Mechanism of the Process, with Special Reference to the Formation of Calcium Carbonate Crystals.T. F. Buehrer and R. F. ReitemeierCite this: J. Phys. Chem. 1940, 44, 5, 552–574Publication Date (Print):May 1, 1940Publication History Published online1 May 2002Published inissue 1 May 1940https://doi.org/10.1021/j150401a002Request reuse permissionsArticle Views161Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts
Heat-Induced Volatile Compounds in Milk (1968)

Milk, preheated at 82 C for 30 rain, was heated to 146 C for four seconds and cooled to 5 C in a tubular heat exchanger. Immediately after heat treatment, the milk was vacuum distilled at 30 C in a semicontinuous, reduced pressure, glass apparatus. Raw milk was distilled in a similar nmnner for a control. Continuous liquid-liquid ethyl ether extractions were employed to recover the compounds from the aqueous distillates. Gas ehromatography~ mass spectrometry, infrared spectrophotometry, and odor conflrmation were used to characterize the compounds in the ethereal concentrates.
Blood glucose level in mice. 1. Evaluation of a new technique of multiple serial sampling. (1966)

ABSTRACT Multiple serial blood glucose level determinations in individual mice were performed on small blood samples (10–25 μl) using the orbital bleeding technique. Glucose was determined specifically by a known enzymatic reaction. Blood glucose determined in this way was found a parameter of high reproducibility and precision, the latter being shown by the finding that differences between individual animals were highly significant in practically all the experiments. The standard deviation of the single measurement in normal mice was ± 8.2 mg/100 ml as determined from 600 samples, which indicated that the technique allows of the detection of blood sugar level changes of about 15 mg/100 ml or more with very high significance, in a group of 5 mice. In the sampling procedure as such, intravenous or subcutaneous saline injections did not necessarily have any effect on the blood glucose level, but interpretation of slight blood sugar changes under experimental conditions should always be based on a comparison with control groups, since the latter may sometimes show a slight but significant change. In normal non-fasting mice (NMRI strain) significant differences in homoeostatic blood glucose level adjustments were demonstrated. In acutely adrenalectomized mice blood glucose levels were lower and more variable than in normals. Alloxan injection (70 mg/kg) was followed in individual mice by a triphasic blood sugar response, as is known from other species.
The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study (2001)

Calcification and fibrointimal proliferation are associated with advanced complicated atherosclerosis in large arteries but may also occur in smaller vessels, resulting in ischaemic tissue necrosis. This study investigates whether the mechanisms of calcification and intimal fibrosis are similar in vessels of different sizes. The localization of osteopontin (OPN), matrix Gla protein (MGP), thrombospondin-1 (TSP-1), and cartilage oligomeric matrix protein (COMP) was investigated in three types of human vascular lesions: atherosclerosis, chronic vascular rejection (CVR) in renal allografts, and calcific uraemic arteriolopathy (calciphylaxis). These lesions were chosen as they affect different sized blood vessels and they exhibit a fibroproliferative intimal reaction, with or without calcification, resulting in luminal obliteration and ischaemic complications. OPN, MGP, TSP-1, and COMP were not detected in normal blood vessels. However, OPN and MGP were expressed at sites of calcification within atherosclerotic lesions and in microvessels in calciphylaxis, suggesting that calcification in different sized vessels may occur by a common mechanism. These proteins were not detected in areas of fibrointimal proliferation. In contrast, TSP-1 was localized primarily within the fibrous tissue of atherosclerotic lesions and was also expressed in the expanded fibrous intima of arteries showing CVR. COMP was localized primarily within the fibrous tissue under the lipid core of the majority of advanced atherosclerotic lesions. TSP-1 and COMP were also detected in areas of microcalcification in atherosclerotic lesions and TSP-1 was detected adjacent to areas of calcification in calciphylaxis. However, neither TSP-1 nor COMP was localized to calcific foci within these lesions. The localization of OPN, MGP, TSP-1, and COMP to pathological, but not normal arterial intima supports a pathogenetic role for these proteins in the development of vascular fibrosis and calcification. Modulation of their production and activity may offer a novel approach to the therapy of a number of vascular diseases.
Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model (2014)

Depression is a significant public health problem, but its etiology and pathophysiology remain poorly understood. Such incomplete understanding likely arises from the fact that depression encompasses a heterogeneous set of disorders. To overcome these limitations, renewed interest in intermediate phenotypes (endophenotypes) has resurfaced, and anhedonia has emerged as one of the most promising endophenotypes of depression. Here, a heuristic model is presented postulating that anhedonia arises from dysfunctional interactions between stress and brain reward systems. To this end, we review and integrate three bodies of independent literature investigating the role of (a) anhedonia, (b) dopamine, and (c) stress in depression. In a fourth section, we summarize animal data indicating that stress negatively affects mesocorticolimbic dopaminergic pathways critically implicated in incentive motivation and reinforcement learning. In the last section, we provide a synthesis of these four literatures, present initial evidence consistent with our model, and discuss directions for future research.
Comparison of Energy Requirements for Conventional and Stirred Ball Milling of Coal-Water Slurries (1987)

This paper presents the results of an investigation of energy requirements for grinding of coal-water slurries in conventional and high speed stirred ball mills. The high speed stirred ball mill, featuring a rotor-stator type of stirring device, has been found to outperform a tumbling ball mill for wet grinding of minus 12 mesh coal to a fineness meeting the requirements of utility fuel. Grinding tests showed that the energy reduction which is possible with stirred mills increases linearly with the percentage of material passing 325 mesh up to 90% and beyond this point, energy reduction is even higher. A direct comparison of stirred ball mill and tumbling ball mill performance resulted in grinding minus 12 mesh (1400μm) coal to approximately 96% passing 325 mesh (45 μm) with a specific energy input of 32.6kWh/T (l.0min retention time) and 58.8kWh/T (60min retention time) respectively.
Veinticinco años del Anuario de Lingüística Hispánica (2009)

A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the muM level against three human tumor cell lines.