gebhart/patrepeval huggingface dataset:
Accuracy of clinical criteria for AD in the Honolulu–Asia Aging Study, a population-based study (2001)

Neuropathologic confirmation and NP density among decedents with clinical AD in this population-based study were lower than reported by referral centers and similar to reports from two other community studies. Ethnic differences in propensity for amyloid deposition as well as differences in clinical severity and representativeness of cases might contribute to these findings.
Electron beam welding fundamentals and applications (1975)

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A six degree of freedom micromanipulator for ophthalmic surgery (2002)

Needs which have arisen in ophthalmic research have motivated the development of a six-degree-of-freedom parallel micromanipulator. The first application of the tool will be in the treatment of retinal venous occlusion, for which micron-scale spherical movement of a glass micropipette tip inside the eye is required. The initial operation mode will be open loop, while future operation will be in a force-reflecting bilateral (macro-master/micro-slave) arrangement. Presented here are some of the design criteria, the mathematical tools used in evaluating various parallel manipulator designs, and the final kinematic configuration.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Scanning SQUID Microscopy for Die Level Fault Isolation (2002)

Abstract This paper presents detailed results of scanning SQUID microscopy (SSM) analyses performed on the frontside and backside of both loose and packaged die. Optical and SEM images of localized defects are shown. Comparisons with alternative physical fault isolation (PFI) techniques like liquid crystal (LC), Schlieren thermal mapping (STM), temperature induced voltage alteration (TIVA), and photon emission microscopy (PEM) are included. Finally, limitations with and potential improvements for die level SSM are also discussed.
Modification of Human Glioma Locomotion In Vitro by Cytokines EGF&comma; bFGF&comma; PDGFbb&comma; NGF&comma; and TNFα (1995)

Cytokines exert receptor-mediated control over glia. Up-regulation of receptor expression of cytokine production corresponds with the acquisition of a neoplastic phenotype. A modified radial dish assay was used to determine whether in vitro locomotion of glioma cells is modified by the epidermal growth factor, the basic fibroblast growth factor, the bb dimer of platelet-derived growth factor, the nerve growth factor, or the tumor necrosis factor alpha. Human glioma cells were plated in the center of a petri dish with one of these cytokines in 0.5 ml agar (50 ng/ml if the cytokine was distributed evenly throughout the dish) at one edge, and 0.5 ml plain agar at the opposite edge. After 24 hours, a central zone of cells was established; the agar was gelatinized. Feeding medium was added to the dish, and slow elution from the agar established a cytokine gradient. Cell counts were performed daily over 6 to 10 days at predetermined distances on both sides of the central zone to assess directional cellular movement with respect to the cytokine gradient and the plain agar. The epidermal growth factor caused continuous chemoattraction, whereas the tumor necrosis factor alpha caused slight chemorepulsion for 24 to 48 hours, followed by strong chemoattraction. The bb dimer of platelet-derived growth factor, the basic fibroblast growth factor, and the nerve growth factor all maintained chemorepulsion over the entire 6 to 10 days. Therefore, the cytokines did affect glioma cell motility in vitro, and the modified radial dish assay used in this study provided a useful in vitro model for assessing the impact of the cytokines on glioma cell locomotion.(ABSTRACT TRUNCATED AT 250 WORDS)
FirstLight: Pluggable Optical Interconnect Technologies for Polymeric Electro-Optical Printed Circuit Boards in Data Centers (2012)

The protocol data rate governing data storage devices will increase to over 12 Gb/s by 2013 thereby imposing unmanageable cost and performance burdens on future digital data storage systems. The resulting performance bottleneck can be substantially reduced by conveying high-speed data optically instead of electronically. A novel active pluggable 82.5 Gb/s aggregate bit rate optical connector technology, the design and fabrication of a compact electro-optical printed circuit board to meet exacting specifications, and a method for low cost, high precision, passive optical assembly are presented. A demonstration platform was constructed to assess the viability of embedded electro-optical midplane technology in such systems including the first ever demonstration of a pluggable active optical waveguide printed circuit board connector. High-speed optical data transfer at 10.3125 Gb/s was demonstrated through a complex polymer waveguide interconnect layer embedded into a 262 mm × 240 mm × 4.3 mm electro-optical midplane. Bit error rates of less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> and optical losses as low as 6 dB were demonstrated through nine multimode polymer wave guides with an aggregate data bandwidth of 92.8125 Gb/s.
Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2V617F mutant allele detection (2013)

QuanTAS-PCR is a simple, cost-efficient, closed-tube method for JAK2 V617F mutation quantification that can detect very low levels of the mutant allele, thus enabling analysis of minimal residual disease. The approach can be extended to the detection of other recurrent single nucleotide somatic changes in cancer.
Experimental test of an infrared phase conjugation adaptive array* (1977)

Results of an experimental program to investigate the properties of an infrared phase conjugation adapative array are described. Both linear and planar adaptive arrays of up to 7 elements using a new integrated frequency phase control technique at 10.6 μm are discussed. The results presented include correction for atmospheric turbulence at ranges of 1, 6, and 9.5 km. Beam broadening induced by turbulence is reduced to the array diffraction limit and target irradiance fluctuations are decreased by a factor of ≈ 20 in strong turbulence. Received irradiance fluctuations are reduced by ≈ 50 db out to 2 kHz. Beam pointing, scanning, and automatic target acquistion and tracking are demonstrated over the 1 mrad array field of view.
Rate and onset cues can improve cochlear implant synthetic vowel recognition in noise (2013)

Understanding speech-in-noise is difficult for most cochlear implant (CI) users. Speech-in-noise segregation cues are well understood for acoustic hearing but not for electric hearing. This study investigated the effects of stimulation rate and onset delay on synthetic vowel-in-noise recognition in CI subjects. In experiment I, synthetic vowels were presented at 50, 145, or 795 pulse/s and noise at the same three rates, yielding nine combinations. Recognition improved significantly if the noise had a lower rate than the vowel, suggesting that listeners can use temporal gaps in the noise to detect a synthetic vowel. This hypothesis is supported by accurate prediction of synthetic vowel recognition using a temporal integration window model. Using lower rates a similar trend was observed in normal hearing subjects. Experiment II found that for CI subjects, a vowel onset delay improved performance if the noise had a lower or higher rate than the synthetic vowel. These results show that differing rates or onset times can improve synthetic vowel-in-noise recognition, indicating a need to develop speech processing strategies that encode or emphasize these cues.
A highly efficient, compact chemical oxygen–iodine laser (1986)

The dependence of the laser output power on the flow velocity at a cavity for a compact chemical oxygen–iodine laser is reported. The flow velocity is changed by using two vacuum pumps (3000 and 15 000 l/min). It becomes experimentally clear that the laser output power is proportional to the flow velocity and the extractable O2(1Δ) concentration. Output power in excess of 100 W has been extracted efficiently. The maximum overall reaction efficiency of 16.8% with the chlorine flow rate of 413 mmol/min is obtained.
Belinostat (PXD101) in Patients with Recurrent or Refractory Peripheral or Cutaneous T-Cell Lymphoma: Results of a Phase II Study. (2007)

Abstract Background: Belinostat (PXD101) is a hydroxamate pan-histone deacetylase inhibitor which demonstrates broad anti-neoplastic activity in vitro and in vivo. Phase I studies have shown that belinostat is well-tolerated. Methods: This Phase II trial evaluated the activity of belinostat in patients (pts) with peripheral T-cell lymphoma (PTCL) or cutaneous T-cell lymphoma (CTCL) who failed ≥ 1 prior systemic therapy. Belinostat (1000 mg/m2) was administered as a 30-min IV infusion on Days 1–5 of a 3-wk cycle. The primary endpoint was objective response (OR) rate analyzed separately for PTCL and CTCL using the Cheson criteria and Severity Weighted Assessment Tool (SWAT), respectively. For each arm, a Simon 2-stage design was used based on target OR rate of 25%, with expansion to 34 pts if ≥ 2/13 OR were observed. Results: In the PTCL arm, 12 pts (9 with stage III/IV disease) were enrolled; (7 PTCL-unspecified (PTCL-U), 2 anaplastic large cell lymphoma (ALCL), 2 angioimmunoblastic T-cell lymphoma and 1 NK-T-cell lymphoma), treated for a median of 2 cycles (range 1–8). Of 11 evaluable pts, 2 achieved a CR and 5 pts had SD. The two CR (11+ and 15+ wks) were both in pts with PTCL-U. A third pt with PTCL-U had SD lasting 14 wks and discontinued treatment due to an adverse event (AE). Both pts with ALCL had durable SD (20+ and 14 wks). In the CTCL arm, 16 pts were enrolled (9 Mycosis Fungoides (MF), 5 Sezary Syndrome (SS), 2 primary cutaneous ALCL) and treated for a median of 2 cycles (range 1–6). Four ORs were observed (25%): 1 CR (ALCL) and 3 PR (MF/SS). The median duration of the OR was 10 wks (range 7 to 39+ wks). Four additional pts had a 25 – 50% decrease in SWAT. Improvement in pruritus score by ≥ 3 on a visual analog scale was reported in 5/6 patients with significant pruritus at baseline. Overall in both study arms the drug was well-tolerated and most AE were grade 1/2 (nausea, fatigue, constipation, diarrhea, and vomiting). Grade 3 AE attributed to the study drug was reported in 7 pts and included peripheral edema, apraxia, adynamic ileus, pruritus, rash, and infections. Only 1 treatment related Grade 4 AE was noted (thrombocytopenia). One patient with progressive PTCL died 6 days after last belinostat dose with ventricular fibrillation and drug causality could not be excluded. Conclusions: Belinostat (PXD101) is generally well tolerated and demonstrates encouraging clinical activity in recurrent or refractory PTCL and CTCL. The objective response rate in both arms has met the pre-defined criteria for study expansion to stage II of enrollment.
Chromatographic profile of carbohydrates in commercial soluble coffees (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChromatographic profile of carbohydrates in commercial soluble coffeesMaurice B. Blanc, Gerald E. Davis, Jean Michel Parchet, and Rinantonio VianiCite this: J. Agric. Food Chem. 1989, 37, 4, 926–930Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/jf00088a022https://doi.org/10.1021/jf00088a022research-articleACS PublicationsRequest reuse permissionsArticle Views256Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Specific impairments of planning (1982)

An information-processing model is outlined that predicts that performance on non-routine tasks can be impaired independently of performance on routine tasks. The model is related to views on frontal lobe functions, particularly those of Luria. Two methods of obtaining more rigorous tests of the model are discussed. One makes use of ideas from artificial intelligence to derive a task heavily loaded on planning abilities. A group of patients with left anterior lesions has a specific deficit on the task. Subsidiary investigations support the inference that this is a planning impairment.
Effects of Antioxidants in Polyethylene Film on Fresh Beef Color (2003)

ABSTRACT: BHA, BHT, rosemary extract, and α‐tocopherol were incorporated into low‐density polyethylene (LDPE) at the 0.1% level and thermoformed into 25‐mm‐dia, 0.25‐mm‐thick discs, which were exposed to the surface of fresh beef and held in contact with a polyvinyl chloride (PVC) overwrap. On d 0, the control treatment with only the PVC overwrap had greater “a” (redness) values, probably due to greater transmission of oxygen to the meat surface. However, by d 7, the control with only the PVC overwrap had lower redness values than any of the other treatments. By d 8 and 9, the meat packaged with the BHA‐impregnated film had higher “a” (redness) values than any of the other film treatments
The antibacterial activity of vancomycin towards Staphylococcus aureus under aerobic and anaerobic conditions (2002)

This study underlines the need for further anaerobic testing using different strain/antibiotic combinations, the results of which will have clinical significance due to the anaerobic nature of some sites of infection.
Light Scattering: Principles and development (1996)

1. Theoretical developments in static light scattering from polymers 2. Static scattering properties of colloidal suspensions 3. Theory of light scattering from rod-like polyelectrolytes 4. Polyelectrolytes in solution 5. Light scattering in concentrated polymer solutions 6. Applications of light scattering to large particle systems 7. Polymer-polymer interactions in dilute solutions 8. Scattering properties of ternary polymer systems 9. Light scattering in complex micellar systems 10. Scattering from block copolymer micellar systems 11. Light scattering by block copolymer liquids in the ordered and disordered states 12. Low angle light scattering and its applications 13. Combined static and dynamic light scattering 14. Size distributions from static light scattering 15. Light scattering and chromatography in combination
Data-driven array processor for video signal processing (1990)

A software approach to digital video signal processing which is based on a programmable array processor that can be used as a building block to construct systems of arbitrary complexity is presented. The processor consists of 16 individually programmable cells with 12-bit RISC (reduced instruction set computer) architectures; the peak performance is 4 GOPS, the maximum data transfer rate across chip boundaries is 750 Mbytes/s. The processor executes statistically scheduled data flow programs. To this end, all communication-whether between cells or between processors-is data-driven (as opposed to clock-driven). Self-timed hardware mechanisms that handle the synchronous data flows automatically and transparently are provided. The technology enables the integration of 1.2 million transistors on a single chip, and clock rates up to 125 MHz. The data flow processor architecture allows the parallelisms inherent in many video applications to be fully exploited; at the same time, the programming task is facilitated through the built-in hardware support for intercell and interprocessor communication.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design (2010)

Inhibitors of the molecular chaperone heat shock protein 90 (Hsp90) are currently generating significant interest in clinical development as potential treatments for cancer. In a preceding publication (DOI: 10.1021/jm100059d ) we describe Astex's approach to screening fragments against Hsp90 and the subsequent optimization of two hits into leads with inhibitory activities in the low nanomolar range. This paper describes the structure guided optimization of the 2,4-dihydroxybenzamide lead molecule 1 and details some of the drug discovery strategies employed in the identification of AT13387 (35), which has progressed through preclinical development and is currently being tested in man.
The in vitro phosphorylation of chromatin by the catalytic subunit of cAMP-dependent protein kinase. (1982)

When a mixture of DNA-free core histones (H) from calf thymus is phosphorylated by the catalytic subunit of cAMP-dependent protein kinase, phosphate is incorporated primarily into H2B and, to a lesser extent, into H3 and H4. In contrast, when the phosphorylation of the DNA-free histones is compared to the phosphorylation of histones in long chromatin or in nucleosome core, only one of the core histones, H3, is phosphorylated. The site of modification of H3 has been identified as serine 10, which is located in the highly charged basic NH2-terminal region of the molecule. The other sites of phosphorylation in H2B nd H4 are completely masked when the histones are complexed with DNA. It is only when the nucleosome core structure is perturbed that these additional sites become accessible to the kinase. If long chromatin which contains H1 is phosphorylated, histone 1 is also phosphorylated by catalytic subunit at serine 38. However, the addition of excess H1 to H1-depleted long chromatin inhibits the phosphorylation of H3. In addition to the histones, the high mobility group (HMG) protein, HMG 14, was also found to be a good substrate for the kinase. Phosphorylation of HMG 17 in comparison was much less.
A moment-based approach to registration of images with affine geometric distortion (1994)

A new method is described for automatic control point selection and matching. First, reference and sensed images are segmented and closed-boundary regions are extracted. Each region is represented by a set of affine-invariant moment-based features. Correspondence between the regions is then established by a two-stage matching algorithm that works both in the feature space and in the image space. Centers of gravity of corresponding regions are used as control points. A practical use of the proposed method is demonstrated by registration of SPOT and Landsat TM images. It is shown that the authors' method can produce subpixel registration accuracy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Inbred Strains Should Replace Outbred Stocks in Toxicology, Safety Testing, and Drug Development (2010)

Methods of toxicity testing, barely changed for several decades, need to be improved. One way forward would be to use a small battery of inbred strains instead of the single outbred stock currently used in toxicity screening. Inbred strains are more stable, more uniform, more repeatable, and better defined than outbred stocks. Genetic variation would be observed as the difference between strains. Safety could be based on the most susceptible strain. Sometimes it may be possible to identify the genes involved. Mechanisms could be explored using gene expression profiling of susceptible and resistant strains. Two committees of toxicologists have concluded that the use of inbred strains, by controlling interindividual variability, would reduce the number of animals needed in toxicity screening, although both "preferred" outbred stocks. This preference appears to have been based on intuition rather than scientific principles. Data from a previously published study on the response to chloramphenicol in an outbred stock and four inbred strains is used to explain the advantages of the multistrain design. Toxicologists, safety pharmacologists, regulatory authorities, and pharmaceutical companies should take a critical look at the types of animals they use if they want to reduce the attrition rate of new drugs.
Catalytic system of the reactive oxygen species on the C60 fullerene basis. (2004)

Photoirradiated water solutions of fullerenes C(60) may be potentially useful for photodynamic therapy of tumors as ROS catalytic system.
Graphical Representation of Chemical Structures in Chemical Abstracts Service Publications (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGraphical Representation of Chemical Structures in Chemical Abstracts Service PublicationsAlan L. GoodsonCite this: J. Chem. Inf. Comput. Sci. 1980, 20, 4, 212–217Publication Date (Print):November 1, 1980Publication History Published online1 May 2002Published inissue 1 November 1980https://pubs.acs.org/doi/10.1021/ci60024a004https://doi.org/10.1021/ci60024a004research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
La producción de un profesor universitario: composición, ponderaciones y corrección por calidad (2002)

Partiendo de una cierta critica a algunos modelos que pretenden evaluar la capacidad investigadora de los profesores universitarios, el autor del presente articulo ofrece unas ideas de gran interes sobre el conjunto de aspectos que deberia tomarse en consideracion al enjuiciar la labor, en su conjunto, del profesor universitario y de los centros universitarios. Tambien cabe destacar la aportacion realizada acerca del avance de la investigacion patrocinada en detrimento de la investigacion financiada por la administracion publica.
Cycle-specific replication of chromosomal and F-plasmid origins (1998)

There have been various proposals for the pattern of F-plasmid replication during the division cycle. Here we show that the recent studies of Gordon et al. (Cell 90, 1113-1121, 1997) on the duplication and segregation of green fluorescent protein (GFP) labeled replication origins of the Escherichia coli chromosome and the F plasmid during the division cycle support the proposal that the F plasmid replicates with a cell-cycle-specific (artiocyclic) pattern.