gebhart/patrepeval huggingface dataset:
A Predictive and Accurate Interconnect Density Function: The Core of a Novel Interconnect-Centric Prediction Engine (2010)

In this paper we propose an accurate and predictive interconnect density function (PIDF) for very deep submicrometer (VDSM) integrated circuits and nano-systems using continuous stochastic functions. PIDF is the core of an interconnect-centric prediction engine, named ICPEn, which gets its input parameters from the design flow of conventional chips, VDSM ICs, and/or nano-systems. Initially layout information is not necessary for PIDF to function properly. In average, we show that PIDF presents at least 10 times more accuracy than previous works using the real data. Moreover, PIDF enables ICPEn to predict the power, the delay, and the crosstalk. Credibility and accuracy of the last three predictions are proven using several standard ISCAS benchmarks and layouts. Using PIDF we extract a safe operating space (SOS) needed for the interconnect-centric design flow where the delay and the power boundary compliance are essential needs in any early design stages of ultra dense ICs. Based on the use of central limit theorem, the other novelty of PIDF is that the statistical distribution employed for the prediction of interconnect density function tends toward a continuous normal distribution which minimizes the residual error of the prediction and verifies the effectiveness of PIDF.
Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains (2017)

γ-Secretase cleavage of the Notch receptor transmembrane domain is a critical signaling event for various cellular processes. Efforts to develop inhibitors of γ-secretase cleavage of the amyloid-β precursor C99 protein as potential Alzheimer's disease therapeutics have been confounded by toxicity resulting from the inhibition of normal cleavage of Notch. We present biochemical and structural data for the combined transmembrane and juxtamembrane Notch domains (Notch-TMD) that illuminate Notch signaling and that can be compared and contrasted with the corresponding traits of C99. The Notch-TMD and C99 have very different conformations, adapt differently to changes in model membrane hydrophobic span, and exhibit different cholesterol-binding properties. These differences may be exploited in the design of agents that inhibit cleavage of C99 while allowing Notch cleavage.
Passive Cooldown Performance of Integral Pressurized Water Reactor (2013)

The design of an integral pressurized water reactor (IPWR) focuses on enhancing the safety and reliability of the reactor by incorporating a number of inherent safety features and engineered safety features. However, the characteristics of passive safety systems for the marine reactors are quiet different from those for the land nuclear power plant because of the more formidable and dangerous operation environments of them. This paper presents results of marine black out accident analyses. In the case of a transient, the passive residual heat removal system (PRHRS) is designed to cool the reactor coolant system (RCS) from a normal operation condition to a hot shutdown condition by a natural circulation, and the shutdown cooling system (SCS) is designed to cool the primary system from a hot shutdown condition to a refueling condition by a forced circulation. A realistic calculation has been carried out by using the RELAP5/MOD3.4 code and a sensitivity analysis has been performed to evaluate a passive cooldown capability. The results of the accident analyses show that the reactor coolant system and the passive residual heat removal system adequately remove the core decay heat by a natural circulation.
Discourse theories vs. Topic-Focus articulation applied to prosodic focus assignment in Romanian (2009)

ldquohellipit is not the argument structure that triggers the intonational phrasing, but the [discourse, subclausal n.b.] relation of backgrounding.rdquo (K. von Heusinger, 2007) Is it? If yes, how? The present paper, maintaining our attempts for applying Prague School's Topic-Focus Articulation (TFA) algorithm on the syntax-prosody interface of Romanian, proposes two comparative lines of investigation for the intonational focus assignment: (A) The TFA algorithm is improved at clause level with hints from Gussenhoven's SAAR (Sentence Accent Assignment Rule), then extended to inter-clause level, i.e. complex sentences. The new shape of the TFA algorithm is applied to compute the Topic-Focus values in the discursive context, while the information-structural (IS) spans of Theme(s)-Rheme(s) are detached, at clause level, as lowest-highest degrees of Communicative Dynamism (CD) vs. Systemic Order (SO). (B) The second approach we experiment for assigning intonational focus and phrasing is based on the combined and intensive use of discourse theories for computing the IS categories and structures: the Background-Kontrast entities (associated with the Prague School's Topic-Focus) are obtained with Asher's (1993) Segmented Discourse Representation Theory (SDRT) analysis, while Theme-Rheme structures within the finite clause are computed with Leong's (2004) Inference-Boundary (IB) algorithm (of Hallidayan inspiration), applied for the first time to Romanian. Furthermore, this second direction is inspired from and joins the IS-discourse theory proposed by Heusinger (2007), which relies on SDRT inter-clausal evolution of discourse variables for computing the Background-Kontrast. While maintaining the classical SDRT (including rhetorical) discourse relations at the inter-clause level, Heusinger introduces a set of IS-semantics relations, and hands down at sub-clause level the rhetorical and focus particle relations with significant role in intonational-prosodic phrasing. Examples of these two types of research are compared to a gold, intonationally annotated set of Romanian sentences, the proposed theoretical and procedural techniques aiming to balance the pessimistic-realistic view on prosody prediction that it is the speaker-presupposition (and hearer-accommodation) which determines the IS focal scopes, rather than the bare text.
Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region. (1994)

BTEB is a GC-box binding transcription factor that can activate human immunodeficiency virus type 1 long terminal repeat and cellular gene promoters containing multiple GC boxes. The present studies showed that although BTEB mRNA was expressed in various tissues of mammals and cell lines, the expression of BTEB protein was confined to the brain and a neuroblastoma Neuro2A (N2A), suggesting that the BTEB expression was translationally regulated in a cell-specific or tissue-specific manner. The BTEB mRNA was characterized by a long (1.26 kilobases( 5'-untranslated region (5'-UTR) containing 10 upstream AUGs (uAUGs) and a GC-rich tract. To examine whether the 5'-UTR controlled the translation in a cell-specific manner, a fusion plasmid composed of the BTEB 5'-UTR and the chloramphenicol acetyltransferase gene was transfected into HeLa and N2A cells. Translational efficiency of the transcribed mRNA was estimated from the chloramphenicol acetyltransferase activity normalized on the basis of the amount of the mRNA. The 5'-UTR was found to decrease the translational efficiency by 7-fold in HeLa cells; that in N2A was not affected. When one of the uAUGs in the 5'-UTR was mutated to AAG, the inhibition of the translation by the 5'-UTR in HeLa cells was reversed; no effect of the mutation was observed in N2A cells. These results suggest that an uAUG in the 5'-UTR of the BTEB mRNA is, at least in part, responsible for the cell-specific translational control of the BTEB expression.
Invertible Convolutional Flow (2019)

Normalizing flows can be used to construct high quality generative probabilistic models, but training and sample generation require repeated evaluation of Jacobian determinants and function inverses. To make such computations feasible, current approaches employ highly constrained architectures that produce diagonal, triangular, or low rank Jacobian matrices. As an alternative, we investigate a set of novel normalizing flows based on the circular and symmetric convolutions. We show that these transforms admit efficient Jacobian determinant computation and inverse mapping (deconvolution) in O(N log N) time. Additionally, element-wise multiplication, widely used in normalizing flow architectures, can be combined with these transforms to increase modeling flexibility. We further propose an analytic approach to designing nonlinear elementwise bijectors that induce special properties in the intermediate layers, by implicitly introducing specific regularizers in the loss. We show that these transforms allow more effective normalizing flow models to be developed for generative image models.
α-Synuclein–induced Aggregation of Cytoplasmic Vesicles in<i>Saccharomyces cerevisiae</i> (2008)

Aggregated alpha-synuclein (alpha-syn) fibrils form Lewy bodies (LBs), the signature lesions of Parkinson's disease (PD) and related synucleinopathies, but the pathogenesis and neurodegenerative effects of LBs remain enigmatic. Recent studies have shown that when overexpressed in Saccharomyces cerevisiae, alpha-syn localizes to plasma membranes and forms cytoplasmic accumulations similar to human alpha-syn inclusions. However, the exact nature, composition, temporal evolution, and underlying mechanisms of yeast alpha-syn accumulations and their relevance to human synucleinopathies are unknown. Here we provide ultrastructural evidence that alpha-syn accumulations are not comprised of LB-like fibrils, but are associated with clusters of vesicles. Live-cell imaging showed alpha-syn initially localized to the plasma membrane and subsequently formed accumulations in association with vesicles. Imaging of truncated and mutant forms of alpha-syn revealed the molecular determinants and vesicular trafficking pathways underlying this pathological process. Because vesicular clustering is also found in LB-containing neurons of PD brains, alpha-syn-mediated vesicular accumulation in yeast represents a model system to study specific aspects of neurodegeneration in PD and related synucleinopathies.
Synthesis of Three-Terminal RC Networks (1955)

Several methods are available for synthesizing three-terminal RC networks when only two of the three short-circuit admittances or two of the three open-circuit impedances are specified. This paper treats the synthesis problem in which all three functions are given; that is, in which terminal behavior of network is entirely prescribed. There is a discussion of necessary conditions which must be satisfied by a set of short-circuit admittances or open-circuit impedances in order that it correspond to a three-terminal RC network. A synthesis method is then developed by means of which networks can be found for a wide variety of specified functions. By means of well-known correspondences between networks of different kinds of elements, similar synthesis methods are easily derived for LC and RL. network, without mutual inductances.
Chronic pain patients are impaired on an emotional decision-making task (2004)

Chronic pain can result in anxiety, depression and reduced quality of life. However, its effects on cognitive abilities have remained unclear although many studies attempted to psychologically profile chronic pain. We hypothesized that performance on an emotional decision-making task may be impaired in chronic pain since human brain imaging studies show that brain regions critical for this ability are also involved in chronic pain. Chronic back pain (CBP) patients, chronic complex regional pain syndrome (CRPS) patients, and normal volunteers (matched for age, sex, and education) were studied on the Iowa Gambling Task, a card game developed to study emotional decision-making. Outcomes on the gambling task were contrasted to performance on other cognitive tasks. The net number of choices made from advantageous decks after subtracting choices made from disadvantageous decks on average was 22.6 in normal subjects (n = 26), 13.4 in CBP patients (n = 26), and -9.5 in CRPS patients (n = 12), indicating poor performance in the patient groups as compared to the normal controls (P < 0.004). Only pain intensity assessed during the gambling task was correlated with task outcome and only in CBP patients (r = -0.75, P < 0.003). Other cognitive abilities, such as attention, short-term memory, and general intelligence tested normal in the chronic pain patients. Our evidence indicates that chronic pain is associated with a specific cognitive deficit, which may impact everyday behavior especially in risky, emotionally laden, situations.
Multiple-dictionary compression using partial matching (2002)

Motivated by the desire to find text compressors that compress better than existing dictionary methods, but run faster than PPM implementations, we describe methods for text compression using multiple dictionaries, one for each context of preceding characters, where the contexts have varying lengths. The context to be used is determined using an escape mechanism similar to that of PPM methods. We describe modifications of three popular dictionary coders along these lines and experiments evaluating their efficacy using the text files in the Calgary corpus. Our results suggest that modifying LZ77 along these lines yields an improvement in compression of about 4%, that modifying LZFG yields a compression improvement of about 8%, and that modifying LZW in this manner yields an average improvement on the order of 12%.
Optical Constants of YVO4 Between 2 and 25 eV (1970)

The optical constants of YVO4 have been determined from 1.96 to 25 eV. In the region of high transparency, from 1.76 to 3.7 eV, the refractive index was determined from prism refraction measurement. Near-normal-incidence reflectivity measurements were made from the absorption threshold to 25 eV. These data were extrapolated to zero and to infinite frequency and the optical constants were obtained from a Kramers-Kronig inversion. Our spectra are in good agreement with the predictions of Walter and Butler. The complex dielectric function, ε1+iε2, was approximated by a simple Lorentzian oscillator model and it was found that the optical spectra from 2 to 25 eV can be attributed to only 24 electrons per YVO4 molecule. The same result is obtained from sum rule computations on ε2 and −Im 1/ε out to 200 eV, using the extrapolated results. The maximum in the loss function, −Im 1/ε occurs at 23 eV.
Determination of Amino Acids from Plants by Paper Chromatography (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Amino Acids from Plants by Paper ChromatographyJ. F. Thompson and C. J. MorrisCite this: Anal. Chem. 1959, 31, 6, 1031–1037Publication Date (Print):June 1, 1959Publication History Published online1 May 2002Published inissue 1 June 1959https://pubs.acs.org/doi/10.1021/ac60150a023https://doi.org/10.1021/ac60150a023research-articleACS PublicationsRequest reuse permissionsArticle Views262Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Guidelines for Managing the Security of Mobile Devices in the Enterprise (2013)

107-347.NIST is responsible
Halftone visual cryptography (2004)

Visual cryptography encodes a secret image SI into n shares of random patterns. If the shares are xeroxed onto transparencies, we can visually decode the secret image by superimposing a qualified subset of transparencies, but no secret information can be obtained from the superposition of a forbidden subset. Such a scheme is mathematically secure, however, it produces random patterns which have no visual meaning, raising the suspicion of data encryption. In this paper, to achieve a higher level of security, we propose halftone visual cryptography, where all shares are halftones of grey level images carrying significant visual information. The proposed methods utilize blue-noise dithering principles to construct halftone shares having visually pleasing attributes.
Exogenous Interferon Administration in Experimental Leishmaniasis: In Vivo and in Vitro Studies (1982)

The potential feasibility of using exogenously administered human interferon for the treatment of selected cases of leishmaniasis prompted us to study the effects of murine interferon on the course of Leishmania tropica infection in C57Bl/6 mice. L cell-derived mouse interferon was administered daily by intraperitoneal (1,000 and 10,000 U) or intralesional (100 U) injection in mice inoculated into footpads with L. tropica amastigotes. Footpad swelling and tissue parasite density were assessed over the course of infection. Interferon treatment did not significantly affect these clinical and parasitological parameters. Furthermore, addition of interferon (100--100,000 U) to cultures of amastigote-infected mouse peritoneal macrophages or to axenic cultures of promastigotes did not affect replication. We conclude that interferon lacks intrinsic antileishmanial activity and does not significantly enhance host defense against Leishmania.
Browser Fingerprint Coding Methods Increasing the Effectiveness of User Identification in the Web Traffic (2020)

Abstract Web-based browser fingerprint (or device fingerprint) is a tool used to identify and track user activity in web traffic. It is also used to identify computers that are abusing online advertising and also to prevent credit card fraud. A device fingerprint is created by extracting multiple parameter values from a browser API (e.g. operating system type or browser version). The acquired parameter values are then used to create a hash using the hash function. The disadvantage of using this method is too high susceptibility to small, normally occurring changes (e.g. when changing the browser version number or screen resolution). Minor changes in the input values generate a completely different fingerprint hash, making it impossible to find similar ones in the database. On the other hand, omitting these unstable values when creating a hash, significantly limits the ability of the fingerprint to distinguish between devices. This weak point is commonly exploited by fraudsters who knowingly evade this form of protection by deliberately changing the value of device parameters. The paper presents methods that significantly limit this type of activity. New algorithms for coding and comparing fingerprints are presented, in which the values of parameters with low stability and low entropy are especially taken into account. The fingerprint generation methods are based on popular Minhash, the LSH, and autoencoder methods. The effectiveness of coding and comparing each of the presented methods was also examined in comparison with the currently used hash generation method. Authentic data of the devices and browsers of users visiting 186 different websites were collected for the research.
Alteration of ribosomes and RNA polymerase in drug-resistant clinical isolates of Mycobacterium tuberculosis (1985)

The biochemical mechanism of resistance to kanamycin, viomycin, and rifampin in five clinical isolates of Mycobacterium tuberculosis was studied. Resistance to viomycin and kanamycin was attributed to altered ribosomes, whereas resistance to rifampin was attributed to an alteration of RNA polymerase. Ribosomal resistance was, however, not the only way of expressing resistance to viomycin and kanamycin.
Commentary the Measurement of Oxidative Damage to DNA by HPLC and GC/MS Techniques (1992)

Oxidative damage to DNA has been measured by quantitating 8-hydroxy-2'-deoxyguanosine (8-OHdGuo) after enzymic digestion of DNA, followed by HPLC separation and electrochemical detection. Alternatively, 8-hydroxyguanine (and a wide range of other base-derived products of free radical attack) may be measured after acidic hydrolysis of DNA or chromatin, followed by derivatization and gas-chromatography/mass spectrometry. Both techniques have comparable sensitivity, but GC/MS enables determination of a wide variety of chemical changes to all four DNA bases and it can be applied to DNA-protein complexes. However, the two techniques do not always give similar results. Potential reasons for this are discussed. Greater attention to methodological questions is required before using measurement of 8-OHdGuo as a "routine" marker of oxidative DNA damage in vivo.
Direct deposition of 10-nm metallic features with the scanning tunneling microscope (1988)

In this preliminary study we have used a modified scanning tunneling microscope (STM) to directly deposit metallic features as small as 10 nm by decomposing organometallic gases containing tungsten and gold. Dots as well as lines have been formed. Tungsen deposits analyzed by Auger electron spectroscopy contained 48% tungsten, 40% carbon, and 12% oxygen. A resistivity of 0.01 Ω/cm for the deposits was measured by aligning the STM to a metal contact pattern. This is the first reported combination of STM lithography with conventional lithography. A discussion of several interesting physical and chemical mechanisms involved in the deposition process is also presented.
Purification and characterization of a novel glycan-phosphatidylinositol-specific phospholipase C from Trypanosoma brucei. (1986)

A novel membrane-bound glycan-phosphatidylinositol-specific phospholipase C, which catalyzes the conversion of membrane form variant surface glycoproteins to soluble variant surface glycoproteins, with the release of sn-1,2-dimyristylglycerol, has been isolated from Trypanosoma brucei. The activity was solubilized from trypanosome membrane fractions in non-ionic detergent and purified by anion exchange chromatography on DEAE-cellulose followed by chromatography on phosphatidylinositol-Sepharose. The enzyme constitutes about 0.1% of the total cellular protein and has an apparent molecular weight of 39,800. The enzyme shows a head group specificity for molecules containing carbohydrate covalently linked to glycan-phosphatidylinositol, but can also act on the monoacyl derivative of membrane form variant surface glycoprotein. It shows no specific ion requirements but is stimulated by thiol-reducing agents and inhibited by ions that thiols chelate.