gebhart/patrepeval huggingface dataset:
A New Isomeric Porous Coordination Framework Showing Single-Crystal to Single-Crystal Structural Transformation and Preferential Adsorption of 1,3-Butadiene from C4 Hydrocarbons (2017)

Reaction of Zn(NO3)2 and 4-(3,5-dimethyl-1H-pyrazol-4-yl) benzoic acid (H2mpba) in a mixed solvent of methanol and toluene gives a new supramolecular isomer for [Zn(Hmpba)2]·guest (1·g). Single crystal X-ray diffraction analysis showed that 1·g possesses a similar local coordination structure with the three known [Zn(Hmpba)2]·guest isomers with 4-fold interpenetrated dia topologies (dissimilar interpenetration directions, void ratio varies from 0% to 28%), but displays a rare 4-connected afw topology consisting of three- and seven-membered rings, and remains a large void ratio of 36% even after 4-fold interpenetration. Interestingly, 1·g can undergo obvious framework contraction of 8.5% in the single-crystal to single-crystal manner upon guest removal to give [Zn(Hmpba)2] (1′). Comparison of the single-crystal structures of 1·g and 1′ showed that the structural transformation arises mainly from ligand conformation change. Single-component N2, CO2, and C4 hydrocarbon gas adsorption measurements for 1′ show different isotherm steps and gate-opening pressures, in which 1,3-butadiene is the lowest in the five C4 hydrocarbons, likely because of it has the smallest molecular cross-section area. Breakthrough simulations on mixed C4 hydrocarbons showed that 1,3-butadiene is preferentially adsorbed from other C4 hydrocarbons.
Recyclable Crosslinked Polymer Networks via One‐Step Controlled Radical Polymerization (2016)

A nitroxide-mediated polymerization strategy allows one-step synthesis of recyclable crosslinked polymeric materials from any monomers or polymers that contain carbon-carbon double bonds amenable to radical polymerization. The resulting materials with dynamic covalent bonds can show full property recovery after multiple melt-reprocessing recycles. This one-step strategy provides for both robust, relatively sustainable recyclability of crosslinked polymers and design of networks for advanced technologies.
Jean Battetta 1909-1996 (1997)

Philippe Michel. Jean Battetta 1909-1996 . In: Nouvelles archives du Muséum d'histoire naturelle de Lyon, tome 35, 1997. Histoire du Muséum d'Histoire Naturelle de Lyon. pp. 57-60.
Streaming Algorithms for Optimal Generation of Random Bits (2012)

Generating random bits from a source of biased coins (the biased is unknown) is a classical question that was originally studied by von Neumann. There are a number of known algorithms that have asymptotically optimal information efficiency, namely, the expected number of generated random bits per input bit is asymptotically close to the entropy of the source. However, only the original von Neumann algorithm has a `streaming property' - it operates on a single input bit at a time and it generates random bits when possible, alas, it does not have an optimal information efficiency. The main contribution of this paper is an algorithm that generates random bit streams from biased coins, uses bounded space and runs in expected linear time. As the size of the allotted space increases, the algorithm approaches the information-theoretic upper bound on efficiency. In addition, we discuss how to extend this algorithm to generate random bit streams from m-sided dice or correlated sources such as Markov chains.
Investigating factors influencing QoS of Internet phone (2003)

An increasing number of applications are using the Internet for voice transmission, and hence there is a growing demand for the Internet phone. However, the Internet was not originally, designed for such isochronous traffic, and it is not clear that it is fully capable of providing the desired quality of service (QoS) for this application. We describe a number of QoS parameters to measure the perceptual quality of audio, including measures of delay, rate and loss. We investigate the factors influencing the QoS of Internet voice, such as packet period and packet size, threshold delay, buffer delay, time slots and Internet sites. We present results from our experiments on how these factors influence the QoS of Internet voice. Based on the results of our experiments, we propose a QoS driven dynamic scheduling algorithm for the real-time transmission of Internet voice packets.
Inverse regulation of cyclin B1 by c-Myc and p53 and induction of tetraploidy by cyclin B1 overexpression. (2001)

We have shown previously that mitotic spindle inhibitors allow the c-Myconcoprotein to uncouple mitosis from DNA synthesis, resulting in the acquisition of tetraploidy. This can also occur in the absence of spindle inhibition if c-Myc deregulation is combined with inactivation of the p53 tumor suppressor. Under these conditions, cyclin B1 protein is induced but retains its normal cell cycle regulation. We now show that the cyclin B1 promoter is directly but oppositely regulated by c-Myc and p53. Enforced expression of cyclin B1 also induces tetraploidy, either after mitotic spindle inhibition or in the absence of such inhibition if cyclin B1 is coexpressed with c-Myc. Cyclin B1 represents a new class of c-Myc target genes that is also regulated by p53. It is also the first identified downstream effector of c-Myc able to produce the chromosomal instability that characterizes virtually all tumor cells.
Hydrolysis and transport of proline-containing peptides in renal brush-border membrane vesicles from dipeptidyl peptidase IV-positive and dipeptidyl peptidase IV-negative rat strains. (1990)

In this investigation, we have demonstrated that the renal brush-border membrane of Fischer 344 rats from the Japanese Charles River Inc. specifically lacks dipeptidyl peptidase IV (DPP IV) activity, whereas the renal brush-border membrane of Fischer 344 rats from three different sources within the United States possesses normal levels of DPP IV activity. Comparison of the brush-border proteins between Charles River (U.S.A.) Fischer 344 rats (DPP IV positive) and Japanese Charles River Fischer 344 rats (DPP IV negative) revealed that a protein band (Mr = 100,000), apparently identical with DPP IV, was absent in the membranes from Japanese Charles River Fischer 344 rats. We examined the handling of radiolabeled beta-casomorphin fragment 1-5 (Tyr-Pro-[3H]Phe-Pro-Gly), a specific substrate for DPP IV, in renal brush-border membrane vesicles isolated from DPP IV-positive and DPP IV-negative rats. Although the membrane vesicles from DPP IV-positive rats were able to hydrolyze the pentapeptide to di- and tripeptides with the subsequent active transport of these products via the H+ gradient-dependent peptide transport system, the membrane vesicles from DPP IV-negative rats failed to hydrolyze the pentapeptide and hence lacked the ability to transport the radiolabel actively from the parent peptide. The H+ gradient-dependent glycyl-sarcosine uptake and the Na+ gradient-dependent proline uptake, however, were normal in DPP IV-negative rats. Urine analysis revealed that the DPP IV-negative rats excreted proline- and hydroxyproline-containing peptides in significantly increased amounts in their urine compared with control rats. Furthermore, following intravenous administration of Tyr-Pro-Phe-Pro-NH2, a peptide that is exclusively hydrolyzed by DPP IV, urinary excretion of the peptide in the intact form was many-fold greater in DPP IV-negative rats than in control rats. These data provide conclusive evidence for the obligatory role of DPP IV in the renal handling of proline (and hydroxyproline)-containing peptides.
Linear Computation for Independent Social Influence (2013)

Recent years have witnessed the increased interests in exploiting influence in social networks for many applications. To the best of our knowledge, from the computational aspect of social influence analysis, most of existing work focus on either describing the influence propagation process or identifying the set of most influential seed nodes. However, these work usually do not distinguish the "independent influence" of each single seed node after removing other seeds. Since it is important to quickly figure out the real contribution of each seed, in this paper we propose to measure the seed's independent influence by a linear social influence model. Specifically, we first describe the linear social influence model, and then define the independent influence under this model for eliminating the "mutual enrichment" between seed nodes. Meanwhile, we find that the influence of a set of nodes is actually the sum of their independent influence, and we also give upper bounds for independent influence. Moreover, these findings are evaluated by two applications, i.e., ranking the seeds by their independent influence and identifying the Top-K influential ones. Finally, the experimental results on several real-world datasets validate the effectiveness and efficiency of the proposed independent social influence measures.
Immune response gene regulation of immunity to <i>Plasmodium berghei</i> sporozoites and circumsporozoite protein vaccines. Overcoming genetic restriction with whole organism and subunit vaccines. (1989)

We conducted a series of experiments to define Ir gene regulation of the immune response to Plasmodium berghei sporozoites and circumsporozoite (CS) protein-derived subunit vaccines. The studies demonstrated that there is no apparent genetic restriction of the capacity to develop protective immunity against a large sporozoite challenge after immunization with irradiation-attenuated P. berghei sporozoites; that the Th response to (Asp-Pro-Ala-Pro-Pro-Asn-Ala-Asn)n, the predominant protective B epitope on the P. berghei CS protein, is genetically restricted and regulated by Class II genes (I-Ab) and by genes in the Class I region (H-2Dk) or telomeric to this region; and that this restriction can be overcome by immunization with a r protein including the entire P. berghei CS protein. The results support the development of full length human CS protein vaccines to take advantage of all potential T epitopes on this protein.
A Compilation of Silicon, Rare Earth Element and Twenty‐One other Trace Element Concentrations in the Natural River Water Reference Material <scp>SLRS</scp>‐5 (<scp>NRC</scp>‐<scp>CNRC</scp>) (2013)

The natural river water certified reference material SLRS ‐5 ( NRC ‐ CNRC ) was routinely analysed in this study for major and trace elements by ten French laboratories. Most of the measurements were made using ICP ‐ MS . Because no certified values are assigned by NRC ‐ CNRC for silicon and 35 trace element concentrations (rare earth elements, Ag, B, Bi, Cs, Ga, Ge, Li, Nb, P, Rb, Rh, Re, S, Sc, Sn, Th, Ti, Tl, W, Y and Zr), or for isotopic ratios, we provide a compilation of the concentrations and related uncertainties obtained by the participating laboratories. Strontium isotopic ratios are also given.
Topic Model Stability for Hierarchical Summarization (2017)

We envisioned responsive generic hierarchical text summarization with summaries organized by topic and paragraph based on hierarchical structure topic models. But we had to be sure that topic models were stable for the sampled corpora. To that end we developed a methodology for aligning multiple hierarchical structure topic models run over the same corpus under similar conditions, calculating a representative centroid model, and reporting stability of the centroid model. We ran stability experiments for standard corpora and a development corpus of Global Warming articles. We found flat and hierarchical structures of two levels plus the root offer stable centroid models, but hierarchical structures of three levels plus the root didn't seem stable enough for use in hierarchical summarization.
Control of resources in broadband networks with quality of service guarantees (1991)

The design principles of resource control algorithms based on asynchronous time-sharing (ATS) are addressed, together with their interaction and cooperation in a wide area network environment, and a framework for evaluating the overall performance of the system is presented. The basic concepts of the ATS framework are presented, along with an overview of an architecture for joint scheduling and admission control. Scheduling mediates the low-level competition for service between cells of different classes; admission control regulates the acceptance or blocking of incoming traffic on a call-by-call basis. The performance of the scheduling algorithms is evaluated and the interaction between scheduling and admission control is quantified. A reference model for broadband networks is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
<i>In vivo</i> control of <i>Mycosphaerella pinodes</i> on pea leaves by a crude bulb extract of <i>Eucomis autumnalis</i> (2002)

Summary We previously reported on the in vitro antifungal activity of a crude whole plant extract from Eucomis autumnalis against seven economically important plant pathogenic fungi. A crude extract of the bulb showed similar in vitro mycelial growth inhibition of the same plant pathogenic fungi as well as that of an eighth fungus, Mycosphaerella pinodes , the cause of black spot or Ascochyta blight, in peas. Subsequently, fourth internode leaves were removed from 4 wk old pea plants, placed on moist filter paper in Petri dishes and inoculated with an M. pinodes spore suspension before and after treatment with the extract. The control of Ascochyta blight by different concentrations of the crude E. autumnalis extract was followed in vivo by leaf symptoms over a 6 day period at 20°C in a growth cabinet. The crude extract prevented M. pinodes spore infection of the leaves when the leaves were inoculated with spores both before or after treatment with the extract, confirming complete inhibition of spore germination. The crude E. autumnalis extract showed no phytotoxic reaction on the leaves even at the highest concentration applied.
Non-catalytic alcoholysis process for production of biodiesel fuel by using bubble column reactor (2015)

Biodiesel fuel is a replacement for diesel as a fuel produced from biomass resources. It is usually defined as a fatty acid methyl ester (FAME) derived from vegetable oil or animal fat. In European countries, such as Germany and France, biodiesel fuel is commercially produced mainly from rapeseed oil, whereas in the United States and Argentina, soybean oil is more frequently used. In many other countries such as Japan and countries in Southeast Asia, lipids that cannot be used as a food source could be more suitable materials for the production of biodiesel fuel because its production from edible oils could result in an increase in the price of edible oils, thereby increasing the cost of some foodstuffs. Therefore, used edible oil, lipids contained in waste effluent from the oil milling process, byproducts from oil refining process and crude oils from industrial crops such as jatropha could be more promising materials in these countries. The materials available in Japan and Southeast Asia for the production of biodiesel fuel have common characteristics; they contain considerable amount of impurities and are high in free fatty acids (FFA). Superheated methanol vapor (SMV) reactor might be a promising method for biodiesel fuel production utilizing oil feedstock containing FFA such as waste vegetable oil and crude vegetable oil. In the conventional method using alkaline catalyst, FFA contained in waste vegetable oil is known to react with alkaline catalyst such as NaOH and KOH generating saponification products and to inactivate it. Therefore, the FFA needs to be removed from the feedstock prior to the reaction. Removal of the alkaline catalyst after the reaction is also required. In the case of the SMV reactor, the processes for removing FFA prior to the reaction and catalyst after the reaction can be omitted because it requires no catalyst. Nevertheless, detailed study on the productivity of biodiesel fuel produced from waste vegetable oils and other non-edible lipids by use of the SMV reactor has not been examined yet. Therefore, this study aims to investigate the productivity of biodiesel produced from waste vegetable oils using the SMV reactor. Biodiesel fuel is a replacement for diesel as a fuel produced from biomass resources. It is generally produced as a FAME derived from vegetable oil by using alkaline catalyzed alcoholysis process. This alkaline method requires deacidification process prior to the reaction process and the alkaline catalyst removal process after the reaction. Those process increases the total cost of biodiesel fuel production. In order to solve the problems in the conventional alkaline catalyzed alcoholysis process, the authors proposed a non-catalytic alcoholysis process called the Superheated Methanol Vapor (SMV) method with bubble column reactor. So, this study aims to investigate the productivity of biodiesel produced from vegetable oils and other lipids using the SMV method with bubble column reactor.
Enantiopure N-protected α-amino glyoxals 1. Synthesis from α-amino acids and some condensation reactions with amines (2000)

A series of N-protected α-amino diazoketones has been prepared from L-amino acids and dipeptides and used as precursors in the synthesis of novel N-protected α-amino glyoxals via oxidation with distilled dimethyldioxirane (DMD) in acetone. The glyoxals have been converted, without purification, into enantiopure imines, pyrazines, quinoxalines, and pyrido[2,3-b]pyrazines via condensation with the appropriate amine or diamine. The molecular structure of the pyrido[2,3-b]pyrazine derived from N-Cbz-L-phenylalanine has been determined by X-ray analysis.
Optical spatial filtering velocimetry sensor for sub-micron, in-plane vibration measurements (2005)

We present a compact, low-cost optical method for real-time detection of speckle translation, here being a single-point measurement of sub-micron, in-plane, translational vibration of a solid structure. The speckles are produced at illumination of a non-specular target surface with coherent light. The scattered light propagates through an imaging system to a spatial filtering system, based on a lenticular array and a spherical lens, which implement a narrow spatial band-pass filter. The spatial filter extracts a given spatial frequency in terms of a quasi-sinusoidal spatial intensity distribution. At the detector plane, the quasi-sinusoidal intensity distribution is monitored at various phase steps, thus two differential sensor signals with a mutual phase shift of 60° provide the phase information of the spatial frequency component to the electronic-processing device. The processing device calculates the real-time in-plane vibration. Within a bandwidth of 160 kHz the sensor and the processing device resolve in-plane displacements of a target surface of less than 6 nm. The presented imaging configuration provides a sensor with no direct sensitivity to the rotational vibration. The calibration of the sensor is independent of the optical wavelength to first order. The accuracy, resolution and reliability of the sensor will be demonstrated and discussed.
Design of a novel gut bacterial adhesion model for probiotic applications (2012)

A new gut bacterial adhesion model has been developed. For this, a continuous-flow bioreactor packed with bacteria-coated beads was designed to simulate the gut lining and other features. In vitro model efficacy shows successful bacterial cell gut adhesions: bacterial adhesion was higher with mucin-alginate compared to controls. In feasibility study, adhesion of Lactobacillus fermentum NCIMB 5221 and Lactobacillus reuteri NCIMB 701359 was investigated for their metabolic activities for bile salt. Bile salt hydrolase (BSH)-active Lactobacillus reuteri exerted higher activity than non-BSH-active L. fermentum. This model has potential use in gut health, probiotic, bacterial cell gut adhesion and other delivery applications.
Abstract 3014: ONC201 anti-cancer effects against solid tumors are mediated through eIF2α kinases HRI and PKR but are PERK-independent (2016)

Abstract ONC201 is a first-in-class small molecule inducer of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway. We recently reported that ONC201-mediated induction of the TRAIL pathway is largely promoted by a preceding early activation of the integrated stress response pathway (ISR) (Kline et al., Sci. Sig., in press, 2015). ONC201 engages the ISR to exert its broad-spectrum anti-cancer effects through pro-apoptotic and anti-proliferative activities. ONC201 upregulates ATF4, the key indicator of ISR activation, in a manner that is dependent on two eIF2α kinases: heme-regulated inhibitor (HRI) and double-stranded RNA activated protein kinase (PKR). Of note, the activation of ATF4 and downstream cell death signaling by ONC201 is PERK-independent. We now further elucidate how the novel dual engagement of HRI and PKR by ONC201 contributes to the anti-cancer effects of ONC201. ONC201 treatment results in early phosphorylation of eIF2α in a manner that is dependent on HRI. On the other hand, we have shown that ONC201-induced downregulation of cyclin D1 is dependent, at least in part, on PKR, but not on eIF2 α phosphorylation per se. This occurs potentially via PKR-mediated ubiquitination and subsequent proteasome degradation of cyclin D1. Treating cells with ONC201 and the proteasome inhibitor MG132 prevents ONC201-induced decrease of cyclin D1. Despite distinctions in their regulatory protein domains, HRI and PKR have both been shown to respond to oxidative stress. Treating cells with ONC201 in the presence of the antioxidant N-acetylcysteine abrogated ATF4 induction. Our findings document a unique activity of ONC201 on protein translation, via activation of HRI and PKR, as well as effects on protein stability through the proteasome leading to anti-cancer effects. Citation Format: Christina Leah B. Kline, Wafik S. El-Deiry. ONC201 anti-cancer effects against solid tumors are mediated through eIF2α kinases HRI and PKR but are PERK-independent. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3014.
Construction and application of a prokaryotic vector which expresses the protein that can be quickly purified by IMAC. (1997)

A vector was constructed by inserting a pair of complementary oligo nucleotides encoding 6 histidine residues into the polylinker's upstream of the prokaryotic high expression vector pBV220. The resultant vector is named pBV222. Proteins expressed by this vector will have a 6-histidine tail as an affinity handle fused to their N-terminus and can be quickly purified by one-step immobilized metal affinity chromatography (IMAC). This plasmid was verified by restriction mapping and DNA sequencing. When GM-CSF and IL-2 cDNA were closed into pBV222, expressed proteins in the inclusion body showed the predicted molecular weight and biological activity. The expressed bacteria were dissolved in 6 mol/L guanidine.HCl and the supernatant was loaded directly to IMAC. IL-2 and GM-CSF fusion proteins were eluted by the pH gradient, and over 90% purity was achieved.
Assessing Visual Performance with Progressive Addition Lenses (2002)

Visual performance tests that involved stimuli subtending the widest visual angles and demanded more fixational shifts were more sensitive in discerning performance differences between the lens designs. In general, PAL's showed marginally diminished performance compared with single-vision lenses, presumably due to their restricted intermediate channel.