gebhart/patrepeval huggingface dataset:
Biochemical Characterization of a Mutant Isoleucyl-Transfer Ribonucleic Acid Synthetase from <i>Escherichia coli</i> K-12 (1971)

Isoleucyl-transfer ribonucleic acid (tRNA) synthetase [l-isoleucine: soluble RNA ligase (adenosine monophosphate), EC 6.1.1.5; IRS] was partially purified from Escherichia coli K-12 and from an ileS mutant that appears to be altered in IRS. The half-life of wild-type IRS, incubated at 60.5 C, is 69 min, whereas that of mutant IRS is 8 min. Mutant IRS shows about a 100-fold lower affinity than wild-type IRS for isoleucine, dl-valine, thiaisoleucine, and O-methyl-dl-threonine, both in the pyrophosphate exchange assay and in the assay of isoleucyl-tRNA formation. The affinity of the mutant enzyme for adenosine triphosphate in the assay of isoleucyl-tRNA formation is 15-fold lower than that of the wild-type enzyme. The affinity of mutant IRS for tRNA is not changed as compared with wild-type IRS. These data show that mutant IRS has an altered structure and clearly confirm that ileS is the structural gene for IRS.
Asymmetric DNA Bending Induced by the Yeast Multifunctional Factor TUF (1989)

TUF is a yeast regulatory factor that binds to conserved DNA sequence elements involved in gene activation or silencing as well as in telomere function. Using gel electrophoresis analyses, we show here that TUF induces DNA bending at a site located upstream of the recognition sequence (rpg box). Several point mutations in the rpg box reduced TUF binding strength without affecting the extent of bending. Selective proteolysis of TUF.DNA complexes further suggested the existence of two separate protein domains involved in DNA bending and specific DNA recognition. DNA bending may be an important feature of multifunctional factors that could help them to recruit other proteins for the formation of multiprotein complexes.
<i>i</i>-PrI Acceleration of Negishi Cross-Coupling Reactions (2010)

The Negishi cross-coupling of arylzinc reagents with various bromoanilines is accelerated by the presence of i-PrI (1 equiv) and furnished the expected biaryls within 5-12 min reaction time at 25 degrees C. Arylzinc reagents can also be cross-coupled under these conditions with a range of aryl bromides bearing an enolizable ester or acidic benzylic protons.
Narrow bandstop filters (1991)

The synthesis of narrow bandstop filters with arbitrary stopband and equiripple passband responses is demonstrated. A transformed frequency variable is used for iterative approximation with automatic bandwidth adjustment and prototype circuit realization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Age-related changes in the human lens: A comparison of Scheimpflug photography and lens density index (1994)

Two quantitative techniques, Scheimpflug photography and the lens density index (LDI), were used to measure lens density in 52 patients. In the Scheimpflug technique, a digitized slitlamp camera provides peak and average nuclear density based on a densitometric analysis of the lens nucleus. The LDI is a psychophysical measurement of the difference between retinal scotopic thresholds for two wave-lengths of light. Both the Scheimpflug technique and LDI revealed an age-related increase in lens density. Peak and average nuclear density were highly correlated with the LDI.
Time-resolved reflectivity characterization of polycrystalline low-temperature-grown GaAs (1999)

Using femtosecond time resolved reflectivity, we have characterized the dynamics of photoinduced generated carriers in a polycrystalline low-temperature-grown GaAs sample. Our measurements are fitted with an analytical expression reliable for low pump power experiments. The sample, which presents no As precipitates, shows an ultrafast subpicosecond response together with a longer picosecond tail that we attribute to the midgap defect states. Moreover, we have observed the influence of surface roughness on the differential reflected signal.
Amine Terminated Reactive Liquid Polymers; Modification of Thermoset Resins (1981)

Abstract Amine terminated reactive liquid polymers (AT-RLP) are synthesized from corresponding carboxyl terminated reactive liquid polymers (CT-RLP) and diamines. The CT-RLPs have a functionality of close to two, the average molecular weight ranging from 2500 to 4000, and Brookfield viscosity ranging from 30 to 600 Pa · s at 27°C. AT-RLPs made from the CT-RLPs have about the same physical properties as the CT-RLPs given above. N-(2-aminoethyl)piperazine (AEP 2 ) is the best diamine among the diamines tried to produce low viscosity and low molecular weight AT-RLPs. Structure of end-groups of AT-RLP is unequivocally identified as a secondary amide and a secondary amine group resulting from the reaction of carboxyl end-groups of CT-RLP and a primary amine group of AEP , . The AT-RLP can be used as a modifier for epoxy resins at room or elevated temperatures to produce castable formulations with properties ranging from plastics to elastomers. The formulations may be useful as a modifier for improvement of crack and/or impact resistance of normally brittle epoxy plastics, as castable elastomers, paints and coatings, sealants, adhesives, especially as solventless adhesives for conveyor belts, hoses, shoes, and as binders for woven or non-woven fibers and cords.
The Effect of Diffraction on the Design of Acoustic Surface Wave Devices (1973)

A complete review of acoustic surface-wave dif- fraction on anisotropic substrates is presented. Full experi- mental verification of theory is provided. The limits of applicability of the parabolic velocity surface theory are quantitatively delineated. Universal diffraction loss design curves are given for all parabolic materials. A limitation in the use of the exact angular spectrum of waves theory occurs for materials having a power flow angle slope - I due to inaccu- rate knowledge of the velocity surface. Both YZ LiNbQ and 16.5 double rotated LiNb03 fall in this category. Approxi- mate diffraction loss design curves are given for YZ LiNb03. A complete tabular summary of all important material proper- ties affecting acoustic surface wave device design is included.
Speech Overlap and Interplay with Disfluencies in Political Interviews (2009)

The reported study focuses on overlapping speech, transcription, annotation and disfluency analysis in an 8-hour audio corpus of French political interviews. Overlaps are frequent (on average 3-4 overlaps per minute) and of short duration (5 % of data), non-intrusive overlaps being significantly shorter than intrusive ones. Disfluencies include repetitions, revisions and filled pauses. Manual annotation achieved a higher inter-annotator agreement when based on the four overlap types: back-channel, turn request, anticipated turn taking and complementary. Discourse markers are also considered in this study. The disfluency rate in overlaps is almost double of the one in non-overlapping speech. Repetitions are the most involved disfluency type, especially for intrusive overlaps (turn requests and complementary). The study highlights interesting differences between active (incoming) and passive (floor holding) overlap speakers, as well as between journalists and interviewees. Index Terms: disfluencies, speech annotation, overlapping speech
Exact splice loss prediction for single-mode fiber (1982)

This paper describes the direct measurement method of spot size for single-mode fibers and its application to the splice loss prediction. Using a core-centering-type automatic fusion splicing machine, predicted splice loss is examined for several MCVD and VAD fibers. The accuracy of splice loss predicted by this method is better than that calculated from core radius and refractive index. The experimental splice loss is equal to the sum of the loss predicted by this method and the loss caused by the splicing technique.
The perioperative complication rate of orthopedic surgery in sickle cell disease: Report of the national sickle cell surgery study group (1999)

Orthopedic disease affects the majority of sickle cell anemia patients of which aseptic necrosis of the hip is the most common, occurring in up to 50% of patients. We conducted a multicentered study to determine the perioperative complications among sickle cell patients assigned to different transfusion regimens prior to orthopedic procedures: 118 patients underwent 138 surgeries. The overall serious complication rate was 67%. The most common of these were excessive intraoperative blood loss, defined as in excess of 10% of blood volume. The next most common complication was sickle cell-related events (acute chest syndrome or vaso-occlusive crisis), which occurred in 17% of cases. While preoperative transfusion group assignment did not predict overall complication rates, higher risk procedures were associated with significantly higher rates of overall complications. Transfusion complications were experienced by 12% of the patients. Two patients died following surgery. Both deaths were associated with an acute pulmonary event. The 52 patients undergoing hip replacements experienced the highest rate of complications with excessive intraoperative blood loss occurring in the majority of patients. Sickle cell-related events occurred in 19% of patients, and surgical complications occurred after 15% of hip replacements and included postoperative hemorrhage, dislocated prosthesis, wound abscess, and rupture of the femoral prosthesis. There were twenty-two hip coring procedures. Acute chest syndrome occurred in 14% of the patients. Overall, decompression coring was a safer, shorter operation. A randomized prospective trial to determine the perioperative and long-term efficacy of core decompression for avascular necrosis of the hip in sickle cell disease is needed. In conclusion, this study demonstrates a high rate of perioperative complications despite compliance with sickle cell perioperative care guidelines. Pulmonary complications and transfusion reactions were common. This study supports the results previously published by the National Preoperative Transfusion in Sickle Cell Disease Group. These results stated that a conservative preoperative transfusion regimen to bring hemoglobin concentration to between 9 and 11 g/dl was as effective as an aggressive transfusion regimen in which the hemoglobin S level was lowered to 30%.
Molecular Analysis of Soybean Lines with Low Palmitic Acid Content in the Seed Oil (2007)

ABSTRACT Palmitic acid is the major saturated fatty acid found in soybean [ Glycine max (L.) Merr.] oil, accounting for approximately 11% of the seed oil content. Reducing the palmitic acid levels of the oil is desirable because of the negative health effects specifically associated with this fatty acid. One of the genetic loci known to reduce the seed palmitate content in soybean is fap nc . Previous studies indicated that fap nc is associated with a deletion in a gene (designated FATB ) encoding 16:0‐ACP thioesterase activity. In this report, we isolated full length cDNAs of three of the four unique FATB genes expressed in soybean and show that the isoform designated GmFATB1a represents the specific gene deleted in lines possessing the fap nc locus. Allele specific primers corresponding to GmFATB1a were used to genotype plants from two F4‐derived populations that were segregating for fap nc The GmFATB1a ‐specific markers were effective in accounting for 62 to 70% of the genotypic variation in palmitate content in the two populations studied. Because the markers developed in this study are 100% linked to the locus of interest, they should be particularly useful in marker‐assisted selection programs designed to lower the palmitic acid levels of soybean oil.
QA/QC issues in OP/FTIR monitoring (1997)

Although much effort has been directed toward developing QA/QC procedures in OP/FTIR monitoring, many QA/QC issues remain unresolved. Despite efforts in this area, there are still no universally accepted procedures for determining the accuracy and precision of OP/FTIR data. When the concentrations of atmospheric species are measured over a long, open path, several factors can influence accuracy and precision. Factors that influence the accuracy and precision of OP/FTIR data, and ways to recognize potential sources of errors, are presented.
Low-density lipoprotein subclass patterns and risk of myocardial infarction (1988)

The association of low-density lipoprotein (LDL) subclass patterns with coronary heart disease was investigated in a case-control study of nonfatal myocardial infarction. Subclasses of LDL were analyzed by gradient gel electrophoresis of plasma samples from 109 cases and 121 controls. The LDL subclass pattern characterized by a preponderance of small, dense LDL particles was significantly associated with a threefold increased risk of myocardial infarction, independent of age, sex, and relative weight. Plasma levels of high-density lipoprotein cholesterol were decreased, and levels of triglyceride, very low—density lipoproteins, and intermediate-density lipoproteins were increased in subjects with this LDL subclass pattern. Multivariate logistic regression analyses showed that both high-density lipoprotein cholesterol and triglyceride levels contributed to the risk associated with the small, dense LDL subclass pattern. Thus, the metabolic trait responsible for this LDL subclass pattern results in a set of interrelated lipoprotein changes that lead to increased risk of coronary heart disease. (<i>JAMA</i>1988;260:1917-1921)
An improved link-16/JTIDS receiver in pulsed-noise interference (2011)

Link-16 provides presumably secure and jam-resistant tactical information for land, sea, and air platforms. Its communication terminal, Joint Tactical Information Distribution System (JTIDS), is a hybrid direct-sequence/frequency-hopping spread spectrum system and features Reed-Solomon (RS) codes for channel coding, cyclic code-shift keying (CCSK) for 32-ary baseband symbol modulation, and minimum-shift keying (MSK) for waveform modulation. In this paper, a noise-normalization combining MSK chip demodulator and an errors-and-erasures RS decoder (EED) are proposed in the JTIDS receiver to replace the original MSK chip demodulator and errors-only RS decoder in order to enhance the anti-jam capability of JTIDS. The symbol error rate (SER) performances of the proposed JTIDS receiver are investigated in pulsed-noise interference (PNI) by a combination of analysis and simulation assuming perfect frequency de-hopping, sequence and chip synchronization, and de-scrambling. Given various fraction of time the jammer is on, the SER performances obtained with the proposed JTIDS receiver are compared to those obtained with the original JTIDS receiver. The results show that the proposed JTIDS receiver not only significantly outperforms the original system as the fraction of time the jammer is on is large, but completely eliminates the effect caused by PNI as the fraction of time the jammer is on is small.
Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. (1997)

In this study, we demonstrate that two important regulators of the cell cycle, cyclin-dependent kinase-4 and its inhibitor p16, are increased in the brains of cases of Alzheimer's disease patients compared with age-matched controls. Both proteins are increased in the pyramidal neurons of the hippocampus, including those neurons containing neurofibrillary tangles and granulovacuolar degeneration. As p16 is not normally found in terminally differentiated neurons, it seems paradoxical that it is increased in Alzheimer's disease unless it is responding to increases in cyclin-dependent kinase-4 or other cell cycle regulators. Induction of the latter, a protein that signals re-entry and progression through the cell cycle, may itself be the consequence of alpha response to a growth stimulus. Re-entry into the cell cycle is likely deleterious in terminally differentiated neurons and may contribute to the biochemical abnormalities, such as oxidative stress and hyperphosphorylated tau protein, as well as the neuronal degeneration characteristic of the pathology of Alzheimer's disease.
The novel antipsychotic drugs. (2002)

Part 1 Clozapine type atypical antipsychotic drugs: the mechanism of action of clozapine in relation to its clinical advantages, Herbert Y. Meltzer Org 5222 - preliminary clinical results, J.M. Ad Sitsen and Maria C. Vrijmoed-de Vries amperozide and some other atypical compounds with antipsychotic effect, Erick G.G. Christensson clozapine - pattern of efficacy in treatment-resistant schizophrenia, Herbert Y. Meltzer amperozide in the treatment of schizophrenic patients - a preliminary report, Anders Bjork, et al. Part 2 Substituted benzamides: comparison of the effects of different substituted benzamides on depamine receptor function in the rat, Sven O. Ogren and M. Hall remoxipride and raclopride - pharmacological background and clinical outcome, Tommy Lewander, et al. Part 3 Dopamine agonists: effects of PD 128483, a novel dopamine autoreceptor agonist, in preclinical antipsychotic tests, Thomas G. Heffner, et al novel dopamine autoreceptor agonists B-HT 920 and EMD 49980 in the treatment of patients with schizophrenia, Klaus Wiedemann, et al efficacy and tolerability of SDZ HDC 912, a partial dopamine D2 agonist, in the treatment of schizophrenia, Dieter Naber, et al the status of Second Generation selective D. dopamine receptor as putative atypical antipsychotics, John L. Waddington and Siobhan A. Daly toward the understanding of the neuroanatomical substrate of schizophrenia - the contribution of savoxepine, Serge F. Bischoff the dopamine D3 receptor as a target for antipsychotics, Jean-Charles Schwartz, et al receptor selectivities of a typical neuroleptics, Philip Seeman. Part 4 Other approaches: glutamatergic mechanisms in neuropsychiatry, John W. Olney enhancement of NMDA-mediated transmission in schizophrenia - effects of milacemide, Carol A. Tamminga, et al glycine in the treatment of schizophrenia - theory and preliminary results, Steven G. Potkin, et al sigma antagonists - potential antipsychotics?, Duncan P. Taylor and R. Francis Schelemmer, Jr clinical efficacy of sigma in schizophrenia, Richard L. Borison, et al antipsychotic potential of 5-Ht3 in schizophrenia, Richard L. Borison, et al antipsychotic potential of 5-HT3 - preclinical data, Michael G. Palfreyman, et al the effects of a novel 5-HT3 antagonist, ondansetron, in schizophrenia - results from uncontrolled trials, Joseph DeVeaugh-Geiss, et al clinical overview of resperidone, Richard L. Borison, et al what makes a neuroleptic atypical, Daniel E. Casey.
Ineffectiveness of Local Wound Anesthesia to Reduce Postoperative Pain After Median Sternotomy (2005)

Postoperative pain control still represents a major challenge in every surgical field. Bupivacaine wound infiltration is frequently used to reduce the pain related to the surgical incision itself. In this randomized study, we investigated the efficacy of bupivacaine local anesthesia after median sternotomy to reduce postoperative pain. Forty-seven patients undergoing major cardiac surgery procedures were allocated randomly to group A (bupivacaine wound infiltration 0.5%; 10 mL, followed by continuous infusion: 10 mg/24 H) or to group C (controls). Extubation time, postoperative arterial blood gases, postoperative pain (assessed by means of a visual analog scale), and morphine consumption were the endpoints of the study. Patients of group C were extubated earlier; blood gases and VAS values were similar in both group. Bupivacaine local analgesia did not improve postoperative pain control after median sternotomy.
A Stabilized HCN Laser for Infrared Frequency Synthesis (1973)

Infrared frequencies have recently been synthesized in suitable diodes up to 88 THz with accuracies of parts in 109. Stabilized lasers are necessary in order to make frequency measurements of higher accuracy. The hydrogen-cyanide laser is the lowest frequency basis laser used in these synthesis schemes, and its stabilization has been the subject of recent interest. The laser is stabilized by locking it to a phase-locked microwave reference chain. Two servo loops are utilized. The first loop is a relatively slow frequency-lock loop with the correction applied to a piezoelectric-translator driver. This loop not only accommodates thermal expansion of the laser, but also serves as an acquisition aiding loop for the second servo. The latter is a phase-locked system with the correction applied to the laser discharge current controller. Data regarding the system stability are presented.
Using character shape coding for information retrieval (2002)

In conventional information retrieval the task of finding users' search terms in a document is simple. When the document is not available in machine readable format, optical character recognition (OCR) can usually be performed. We have developed a technique for performing information retrieval on document images in such a manner that the accuracy has great utility. The method makes generalisations about the images of characters, then performs classification of these and agglomerates the resulting character shape codes into word tokens based on character shape coding. These are sufficiently specific in their representation of the underlying words to allow reasonable performance of retrieval. Using a collection of over 250 Mbytes of document texts and queries with known relevance assessments, we present a series of experiments to determine how various parameters in the retrieval strategy affect retrieval performance and we obtain a surprisingly good result.
<i>Planck</i>intermediate results (2013)

We present the scaling relation between Sunyaev-Zeldovich (SZ) signal and stellar mass for almost 260,000 locally brightest galaxies (LBGs) selected from the Sloan Digital Sky Survey (SDSS). These are predominantly the central galaxies of their dark matter halos. We calibrate the stellar-to-halo mass conversion using realistic mock catalogues based on the Millennium Simulation. Applying a multi-frequency matched filter to the Planck data for each LBG, and averaging the results in bins of stellar mass, we measure the mean SZ signal down to M * 2 10 11 M , with a clear indication of signal at even lower stellar mass. We derive the scaling relation between SZ signal and halo mass by assigning halo properties from our mock catalogues to the real LBGs and simulating the Planck observation process. This relation shows no evidence for deviation from a power law over a halo mass range extending from rich clusters down to M 500 2 10 13 M , and there is a clear indication of signal down to M 500 4 10 12 M . Planck's SZ detections in such low-mass halos imply that about a quarter of all baryons have now been seen in the form of hot halo gas, and that this gas must be less concentrated than the dark matter in such halos in order to remain consistent with X-ray observations. At the high-mass end, the measured SZ signal is 20 % lower than found from observations of X-ray clusters, a difference consistent with the magnitude of Malmquist bias effects that were previously estimated for the X-ray sample.
REGRESSION OF TUMOUR GROWTH AFTER ADMINISTRATION OF ALKOXYGLYCEROLS (1978)

A regression of tumour growth is observed when alkoxyglycerols are administered prior to radiation treatment of patient suffering from cancer of the uterine cervix. This regression has been demonstrated by a change in the quotient between the incidence of early and advanced stages.