gebhart/patrepeval huggingface dataset:
Cardiovascular Manifestations of COVID-19 Infection (2020)

SARS-CoV-2 induced the novel coronavirus disease (COVID-19) outbreak, the most significant medical challenge in the last century. COVID-19 is associated with notable increases in morbidity and death worldwide. Preexisting conditions, like cardiovascular disease (CVD), diabetes, hypertension, and obesity, are correlated with higher severity and a significant increase in the fatality rate of COVID-19. COVID-19 induces multiple cardiovascular complexities, such as cardiac arrest, myocarditis, acute myocardial injury, stress-induced cardiomyopathy, cardiogenic shock, arrhythmias and, subsequently, heart failure (HF). The precise mechanisms of how SARS-CoV-2 may cause myocardial complications are not clearly understood. The proposed mechanisms of myocardial injury based on current knowledge are the direct viral entry of the virus and damage to the myocardium, systemic inflammation, hypoxia, cytokine storm, interferon-mediated immune response, and plaque destabilization. The virus enters the cell through the angiotensin-converting enzyme-2 (ACE2) receptor and plays a central function in the virus's pathogenesis. A systematic understanding of cardiovascular effects of SARS-CoV2 is needed to develop novel therapeutic tools to target the virus-induced cardiac damage as a potential strategy to minimize permanent damage to the cardiovascular system and reduce the morbidity. In this review, we discuss our current understanding of COVID-19 mediated damage to the cardiovascular system.
Efficient and low-noise operation in a gain-flattened 1580 nm band EDFA (2003)

The power conversion efficiency of 35% and the noise figure of 5.1 dB are obtained in the 1580-nm band erbium-doped fiber amplifier (EDFA) composed of the first stage backward pumped at 980 nm and the second stage backward pumped at 1480 nm.
Graphene-Supported NaTi<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub>as a High Rate Anode Material for Aqueous Sodium Ion Batteries (2014)

NaTi2(PO4)3/graphene composites had been synthesized by a sol-gel and post heat-treatment approach. Different graphene content in the final NaTi2(PO4)3/graphene composites had a large influence on the electrochemical performance of aqueous rechargeable sodium ion batteries (NIBs), especially the rate property. Among the prepared NaTi2(PO4)3/graphene composites, the 6.84% graphene contained NaTi2(PO4)3 sample displayed the highest capacity, which was about 63.5 mA h g−1 at 20 C, and retained 71% of the initial capacity after 2000 cycles. Furthermore, this sample also exhibited good cycling performance in non-aqueous NIBs, with a reversible capacity of 102 mA h g−1 after 700 cycles at 100 mA g−1. The graphene plays a critical role in enhancing the cycling stability and rate property of NaTi2(PO4)3 in rechargeable NIBs. Composited with appropriate amount of grephene, NaTi2(PO4)3 possesses better electrochemical performance.
Modified adriamycin‐vincristine‐dexamethasone (m‐VAD) in primary refractory and relapsed plasma cell myeloma: an NCI (Canada) pilot study (1992)

The purpose of this single arm phase II study was to test a modified version of the three drug combination vincristine, adriamycin and dexamethasone (m-VAD), in which intravenous vincristine (0.4 mg/d) and adriamycin (9 mg/m2 per day) infusions are administered for only 2 h on days 1-4 of each 28 d cycle, in patients with refractory multiple myeloma. In addition, only two 4 d courses of dexamethasone 40 mg/d was given during each cycle. The entry criteria for 44 patients included plasma cell myeloma and a measurable monoclonal peak, either refractory to initial treatment with melphalan and prednisone, or resistant to melphalan and prednisone after initially responding (resistant relapsed disease, 27 patients). Patients treated previously with chemotherapy other than melphalan and prednisone were excluded. There were no complete responses. Of the 41 evaluable patients who completed at least one course of therapy 11 had a partial response (27%, 95% C.I. 14-40%). The response rates were 19% for primary refractory disease patients, and 32% for those with resistant relapsed disease. The median duration of response was 4 months. The median survival for all 44 patients was 7.6 months (5.5 months for primary refractory patients, and 10 months for relapsed resistant disease patients). Episodes of documented bacterial infection occurred in 12 patients, and 10 patients had minor viral infection. The dexamethasone dose was reduced in 12 patients. The median neutrophil nadir was 1.2 x 10(9)/l, and median platelet nadir was 147 x 10(9)/l. Five deaths were judged as treatment related and occurred during marrow cytopenia. The results of this modified form of VAD are inferior to that reported previously for 4 d continuous infusions of vincristine and doxorubicin. This could be related to either patient selection factors, or to a reduction of the efficacy of the drug combination produced by either the shortened intravenous infusions and/or omission of one 4 d course of dexamethasone.
Release of volatile organic compounds from the lung cancer cell line NCI-H2087 in vitro. (2009)

Our findings demonstrate that certain compounds can be cancer cell derived and thus may be indicative of the presence of a tumor. Some compounds were not released but seem to be consumed by cancer cells.
The Imaging Properties of a Silicon Wafer X-Ray Telescope (1994)

Silicon wafers have excellent optical properties --- low microroughness and good medium-scale flatness --- which Make them suitable candidates for inexpensive flat-plate grazing-incidence x-ray mirrors. On short spatial scales (less than 3 mm) the surface quality of silicon wafers rivals that expected of the Advanced X-Ray Astrophysics Facility (AXAF) high-resolution optics. On larger spatial scales, however, performance may be degraded by the departure from flatness of the wafer and by distortions induced by the mounting scheme. In order to investigate such effects, we designed and constructed a prototype silicon-wafer x-ray telescope. The device was then tested in both visible light and x rays. The telescope module consists of 94 150-mm-diameter wafers, densely packed into the first stage of a Kirkpatrick-Baez configuration. X-ray tests at three energies (4.5, 6.4, and 8.0 keV) showed an energy-independent line spread function with full width at half maximum (FWHM) of 150 arcseconds, dominated by deviations from large-scale flatness.
Effect of Serotype on Focus and Mortality of Invasive Pneumococcal Disease: Coverage of Different Vaccines and Insight into Non-Vaccine Serotypes (2012)

Marked differences exist between serotypes in clinical presentation and outcome, and these should be considered when evaluating the potential impact of higher valency vaccines on overall disease burden and associated QALY loss.
Fall Bulletin 2014 (2014)

FEATURES • 5 Modern Adaptations to Life in Java • 10 Figures of Plebeian Modernity: Film • Projection as Performance in Siam/Thailand • 17 The MOSAIC Project: Understanding the Intersections of Climate Change Mitigation and the Large-scale Acquisition of Land and Resources in the Contemporary Landscapes of Cambodia and Myanmar • 21 Photo Essay: Growing up Adat in Indonesia • 25 Paradigm Shifts in Buddhist Scholarship • 27 A Bittersweet Farewell and Heartfelt Thanks • 29 Students in Southeast Asia: What it Takes: Laying the Foundation for a Collaborative Urban Planning Workshop, and The EGBOK Mission in Siem Reap, Moving Forward • NEWS • 33 Fall 2014 Lectures • 34 Announcements • 35 Awards • 36 The Echols Collection • 38 SEAP • 40 SEAP Publications • 43 Welcome New Faculty and Associates in Research • 44 SEAP Faculty Listing • 45 New Johnson Museum Acquisitions
Polarisation insensitive 1300 nm laser amplifiers employing both compressively and tensile strained quantum wells in a single active layer (2002)

Polarization insensitive operation was obtained fro 1300 nm multiple quantum well (MQW) semiconductor amplifiers by incorporating three tensile strained and four compressively strained wells in a single active layer. By the introduction of window regions at the facets, the performance could be improved even further leading to 22 dB fiber to fiber gain for both the transverse electric (TE) and transverse magnetic (TM) polarization directions. The window regions lead to a reduction of the facet reflectivity down to a value of 3 /spl times/ 10/sup -5/, while at least maintaining the high chip to fiber coupling efficiency. In addition, a record low fiber coupled noise figure of 6 dB and a fiber coupled saturation output power of 13 dBm were obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis and Reactivity of Bicycles Derived from Tartaric Acid and α-Amino Acids:  A Novel Class of Conformationally Constrained Dipeptide Isosteres Based upon Enantiopure 3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic Acid. (2000)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionSynthesis and Reactivity of Bicycles Derived from Tartaric Acid and α-Amino Acids: A Novel Class of Conformationally Constrained Dipeptide Isosteres Based upon Enantiopure 3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic Acid.Antonio Guarna, Antonio Guidi, Fabrizio Machetti, Gloria Menchi, Ernesto G. Occhiato, Dina Scarpi, Sauro Sisi, and Andrea TrabocchCite this: J. Org. Chem. 2000, 65, 15, 4782Publication Date (Web):June 29, 2000Publication History Published online29 June 2000Published inissue 1 July 2000https://doi.org/10.1021/jo004022fCopyright © 2000 American Chemical SocietyRequest reuse permissions This publication is free to access through this site. Learn MoreArticle Views372Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (14 KB) Get e-Alertsclose Get e-Alerts
High-speed dual-output-channel stage-selectable TDI CCD image sensor for high-resolution applications (1995)

TDI sensors are a proven means of increasing the responsivity in a line scan imaging application. This paper describes the development of a family of high speed 96 stage TDI sensors. The sensor is available in a high resolution 2048 element version. A 512 element part will also be made. The number of TDI stages in the sensor can be selected in blocks of 6, 12, 24, 48, and 96 stages thus providing optimum sensitivity and performance over a wide range of illumination conditions. The device is fabricated using double metal, triple poly, buried channel, NMOS CCD process. The imaging region is 4-phase, 2-poly for maximum charge storage and optimum MTF. The pixel pitch on the sensor is 13 micrometers . The sensor employs a dual channel, 2-phase, 2-poly output shift register for high speed read-out. This technique enables halving the driving clock frequency thus reducing the power consumption which can be a severe problem at large data rates. Another benefit of dual channels is that each horizontal CCD (HCCD) pixel corresponds to two vertical CCD (VCCD) registers. As a result the charge storage capacity of the HCCD is doubled without having to increase the register width. The developed sensor operates at a combined data rate of up to 40 MHz. The maximum line speeds are 32,000 and 14,000 lines/sec for the 512 and 2048 element parts respectively. Methods to reduce the fixed pattern noise resulting from transfer inefficiencies between the two HCCD channels have been implemented.
Adhesion molecules and TGF-β1 are involved in the peritoneal dissemination of NUGC-4 human gastric cancer cells (1997)

Peritoneal dissemination frequently occurs after surgery in patients with gastric cancer. The presence of peritoneal metastasis after surgery affects prognosis. Very little is known about the biochemical processes involved in the initial attachment of gastric cancer cells to peritoneal mesothelial cells. We conducted in vitro and in vivo studies to assess the role of adhesion molecules and TGF-beta1 in this process, using 4 cell lines derived from human gastric cancers. NUGC-4 cells, which disseminate early after inoculation into the abdominal cavity of nude mice, predominantly express CD44H and beta1 integrin. We found that NUGC-4 cells adhered to monolayers of mesothelial cells more firmly than to other cell lines. Adhesion of NUGC-4 cells to mesothelial cells was partially inhibited by antibodies against CD44H or the beta1 subunit of integrin and was completely blocked by a combination of these 2 antibodies. Treatment with ligands for CD44H and beta1 integrin also inhibited adhesion. In the NUGC-4 cell culture medium, larger amounts of TGF-beta1 were detected in relation to the increase in cancer cells than in the other cell lines. TGF-beta1 increased the expression of CD44H in NUGC-4 cells and in mesothelial cells and augmented adhesion and implantation of NUGC-4 cells to mesothelial cells accompanied by accumulation of extracellular matrix (ECM) components. Treatment with antibodies against both CD44H and beta1 integrin inhibited the dissemination of NUGC-4 cells in the peritoneal cavity of nude mice and prolonged their survival time. Our findings suggest that CD44H and integrins mediate the initial attachment of gastric cancer cells to mesothelial cells and that TGF-beta1 participates in the promotion of the disease. Increased expression of CD44H and of the amount of ligands for CD44H and integrins induced by TGF-beta1 promotes early development of peritoneal dissemination.
Out-of-Step Protection Using State-Plane Trajectories Analysis (2013)

This paper proposes a novel out-of-step protection technique using the state-plane representation of the generator speed and power angle. The critical clearing angle is computed using the principle that the total energy of the system at the instant the fault is cleared should be equal to the maximum potential energy of the system. The critical clearing time corresponding to the value of critical clearing angle is obtained directly using the time calibration of the relative speed versus power-angle solution curve. The simultaneous calculation of the critical clearing angle and the time make the proposed approach much faster than the two-blinder scheme. The proposed state-plane prediction scheme is used to detect the first swing out-of-step condition in a two-area test system using system-wide information. The two generators are represented with a single-machine infinite bus equivalent system, and the state-plane algorithm is applied to the reduced equivalent. Electromagnetic transient simulations are carried out using <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">${\rm PSCAD/EMTDC}^{\rm TM}$</tex></formula> to test the proposed algorithm in the two-area test systems. The simulation studies show that the proposed method is computationally efficient and accurate. The technique also does not require any offline studies.
Thymic epithelium is programmed to induce preleukemic changes in retrovirus expression and thymocyte differentiation in leukemia susceptible mice: studies on bone marrow and thymic chimeras. (1982)

In the leukemia-prone AKR thymus, ecotropic and xenotropic-related viruses are expressed that generate leukemogenic recombinant viruses before the onset of leukemia. We have shown previously that (AKR X NZB)F1 hybrid mice do not develop leukemia because they severely restrict the expression of these retroviruses in their thymuses. The thymic microenvironment of the (AKR X NZB)F1 mice appeared to be of particular importance in determining this restriction, which was specified by an NZB-derived genetic influence. In the present study we analyze reciprocal thymus graft and irradiation bone marrow chimeras to establish that this influence is exerted by thymic reticuloepithelial cells. Prospective studies with thymic epithelial grafts from young mice show that the AKR thymic epithelium can simultaneously induce the amplified expression of retroviral genes, and changes in patterns of thymocyte differentiation that precede the development of leukemia, whereas the (AKR X NZB)F1 thymic epithelium is deficient in this regard.
SPATIAL AND SEASONAL VARIATIONS IN HYDRAULIC CONDUCTIVITY IN RELATION TO FOUR DETERMINATION TECHNIQUES (1994)

Various techniques available to determine saturated hydraulic conductivity involve different methodologies and analytical models in their computations.In this study, these differences are quantified in relation to the variations in Ks estimates obtained by four techniques: Double Ring Infiltrometer (Rl), Rainfall Simulator (RS), Guelph Permeameter (GP) and Guelph Infiltrometer (Gl).Results show that the Ks values obtained with the Gl and RS have a higher mean than values obtained by the Rl and GP techniques.The Rl and RS yield Ks estimates exhibiting lower variability as compared to those obtained with the GP and Gl techniques.This study further revealed that the variations in Ks in the spatial and temooral domains can be exoected to be as substantial as those due to the tech nioues themselves. R6sum6Plusieurs techniques sont disponibles pour d6terminer la conductivit6 hydraulique satur6e.Les techniques diffdrent par leur m6thodologie et par les moddles analytiques utilis6s dans les calculs.Dans cette 6tude, les diff6rences entre les techniques sont quantifi6es en relation avec les variations d'estimations de Ks obtenues par quatre diff6rentes m6thodes: Double Ring Infiltrometer (Rl), Rainfall Simulator (RS), Guelph Permeameter (GP) and Guelph Infiltrometer (Gl).Les r6sultats montrent que les valeurs de Ks obtenues avec le Gl et le RS ont une moyenne plus 6lev6e que celle calcul6e avec les valeurs de Ks obtenues avec les techniques de GP et Gl.Les techniques Rl et RS donne des estimations de Ks qui d6montrent moins de variabilit6 oue celles obtenues avec les methodes GP et Gl.Cette 6tude montre aussi que les variations de Ks dans les domaines spatiales et temporales peuvent 6tre aussi importantes que les variations dues aux tech- niques employ6es.
Simultaneous localization and mapping with infinite planes (2015)

Simultaneous localization and mapping with infinite planes is attractive because of the reduced complexity with respect to both sparse point-based and dense volumetric methods. We show how to include infinite planes into a least-squares formulation for mapping, using a homogeneous plane parametrization with a corresponding minimal representation for the optimization. Because it is a minimal representation, it is suitable for use with Gauss-Newton, Powell's Dog Leg and incremental solvers such as iSAM. We also introduce a relative plane formulation that improves convergence. We evaluate our proposed approach on simulated data to show its advantages over alternative solutions. We also introduce a simple mapping system and present experimental results, showing real-time mapping of select indoor environments with a hand-held RGB-D sensor.
Characterization of a Murine IgG3 Monoclonal Antibody against <i>Chlamydia</i>‐Specific Lipopolysaccharide and its Purification by Affinity Chromatography on IgG Fc‐Receptors from <i>Streptococcus Dysgalactiae</i> (1991)

Purification of a murine IgG3 monoclonal antibody (Mab 22) directed against an epitope of Chlamydia-specific lipopolysaccharide by affinity chromatography on recently described solid phase IgG Fc-receptors from Streptococcus dysgalactiae is reported. SDS-PAGE studies revealed the purity of the eluted antibody. The purified Mab 22 was characterized by determination of class, subclass and light chain-type, and by dot tests and immunoblot analysis.
Lipopolysaccharide Stimulates the Proliferation of Human CD56+CD3− NK Cells: A Regulatory Role of Monocytes and IL-10 (2000)

NK cells recognize and kill tumor cells and normal cells, and these play an important role in immune defense in cancer, infectious disease, and autoimmunity. NK killing is regulated by positive or negative signals derived from the interaction of surface receptors with ligands on the target cells. However, the mechanisms controlling the proliferation and maintenance of NK cells in normal human individuals are less clearly defined. In this study, using an entirely autologous system, we demonstrate that human peripheral blood CD3-CD56+, killer cell-inhibitory receptor (KIR)-expressing cells proliferate and expand in response to LPS. These responses are enhanced in the presence of anti-IL-10 receptor-blocking Abs or on the removal of CD14+ cells from the cultures. This enhancement is also reflected in substantial increases in cytolytic activity and IFN-gamma production. The negative effect of CD14+ cells may also be IL-10 mediated, IL-10 being lost from the culture supernatants of CD14-depleted PBMC and rIL-10 reversing the effect of this depletion. On the other hand, mRNA for the p35 and p40 subunits of IL-12 is still induced in CD14-depleted cultures. The expansion of CD3-CD56+ cells was also inhibited by CTLA4-Ig, indicating a role for CD80/86. B lymphocytes were not required for the expansion of CD3-CD56+ cells, whereas removal of MHC class II+ cells from CD14-depleted cultures resulted in a complete abrogation of these responses. Expansion of CD3-CD56+ cells was reconstituted in MHC class II-depleted cell cultures by adding back monocyte-derived dendritic cells. These results indicate that the responses of CD3-CD56+ NK cells to LPS may be driven by a MHC class II+ B7+ CD14- peripheral population, most likely blood dendritic cells.
Pressure-sensitive schottky barrier transistor and switching device for keyboard applications (1970)

A pressure-sensitive Schottky barrier transistor and a pressure-triggering Schottky barrier switching device having a thyristor action have been developed. The electrical characteristics of these devices as well as application for a desk calculator keyboard will be reviewed.