gebhart/patrepeval huggingface dataset:
A low-spurious low-power 12-bit 300MS/s DAC with 0.1mm<sup>2</sup> in 0.18&#x00B5;m CMOS process (2013)

A low-spurious low-power 12-bit 300MS/s digital-to-analog converter (DAC) is proposed with only 0.1mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> active area in a 0.18μm CMOS process. Measured performance achieves > 70dB spurious-free dynamic range (SFDR) in the whole Nyquist bandwidth and consumes 35mW. Two popular figure-of-merits (FoMs) are used to compare this design with other published DACs, with the proposed design performing best.
Quantum lattice-gas model for computational fluid dynamics (2001)

Quantum-computing ideas are applied to the practical and ubiquitous problem of fluid dynamics simulation. Hence, this paper addresses two separate areas of physics: quantum mechanics and fluid dynamics (or specifically, the computational simulation of fluid dynamics). The quantum algorithm is called a quantum lattice gas. An analytical treatment of the microscopic quantum lattice-gas system is carried out to predict its behavior at the mesoscopic scale. At the mesoscopic scale, a lattice Boltzmann equation with a nonlocal collision term that depends on the entire system wave function, governs the dynamical system. Numerical results obtained from an exact simulation of a one-dimensional quantum lattice model are included to illustrate the formalism. A symbolic mathematical method is used to implement the quantum mechanical model on a conventional workstation. The numerical simulation indicates that classical viscous damping is not present in the one-dimensional quantum lattice-gas system.
The role of β-adrenoceptor signaling in skeletal muscle: therapeutic implications for muscle wasting disorders (2009)

Multiple studies have identified anticachectic effects of beta-agonists and their therapeutic potential for pathologic states when muscle protein hypercatabolism is indicated. Future studies examining beta-agonist administration for muscle wasting conditions need to separate beneficial effects on skeletal muscle from potentially deleterious effects on the heart and cardiovascular system.
Proline biosynthesis in Saccharomyces cerevisiae: analysis of the PRO3 gene, which encodes delta 1-pyrroline-5-carboxylate reductase (1992)

The PRO3 gene of Saccharomyces cerevisiae encodes the 286-amino-acid protein delta 1-pyrroline-5-carboxylate reductase [L-proline:NAD(P+) 5-oxidoreductase; EC 1.5.1.2], which catalyzes the final step in proline biosynthesis. The protein has substantial similarity to the pyrroline carboxylate reductases of diverse bacterial species, soybean, and humans. Using RNA hybridization and measurements of enzyme activity, we have determined that the expression of the PRO3 gene appears to be constitutive. It is not repressed by the pathway end product (proline), induced by the initial substrate (glutamate), or regulated by the general control system. Its expression is not detectably altered when cells are grown in a wide range of nitrogen sources or when glycerol and ethanol replace glucose as the carbon source. The possibility that this enzyme has other functions in addition to proline biosynthesis is discussed.
Calmodulin Regulates Ca2+-sensing Receptor-mediated Ca2+ Signaling and Its Cell Surface Expression (2010)

The Ca(2+)-sensing receptor (CaSR) is a member of family C of the GPCRs responsible for sensing extracellular Ca(2+) ([Ca(2+)](o)) levels, maintaining extracellular Ca(2+) homeostasis, and transducing Ca(2+) signaling from the extracellular milieu to the intracellular environment. In the present study, we have demonstrated a Ca(2+)-dependent, stoichiometric interaction between CaM and a CaM-binding domain (CaMBD) located within the C terminus of CaSR (residues 871-898). Our studies suggest a wrapping around 1-14-like mode of interaction that involves global conformational changes in both lobes of CaM with concomitant formation of a helical structure in the CaMBD. More importantly, the Ca(2+)-dependent association between CaM and the C terminus of CaSR is critical for maintaining proper responsiveness of intracellular Ca(2+) responses to changes in extracellular Ca(2+) and regulating cell surface expression of the receptor.
An extendable framework for expectation-based visual servoing using environment models (1995)

Visual servoing is a manipulation control strategy that precisely positions objects using imprecisely calibrated camera-lens-manipulator systems. In order to quickly and easily integrate sensor-based manipulation strategies such as visual servoing into robotic systems, a system framework and a task representation must exist which facilitates this integration. The framework must also be extendable so that obsolete sensor systems can be easily replaced or extended as new technologies become available. In this paper we present a framework for expectation-based visual servoing which visually guides tasks based on the expected visual appearance of the task. The appearance of the task is generated by a model of the environment that uses texture-mapped geometric models to represent objects. A system structure which facilitates the integration of various configurations of visual servoing systems is presented, as well as a hardware implementation of the proposed system and experimental results using a stereo camera system.
Strehl ratio and scintillation theory for uplink Gaussian-beam waves: beam wander effects (2006)

First-order weak-fluctuation Rytov theory predicts that the longitudinal (on-axis) component of the scintillation index of an uplink collimated beam will become significantly smaller as the size of the transmitter aperture increases up to around 100 cm. However, the results of recent computer simulations are at odds with this behavior, and we believe that this discrepancy is due to the fact that the conventional Rytov theory does not correctly account for the effects of beam wander on the scintillation index. We present a theoretical structure that accurately describes far-field irradiance fluctuations caused by uncorrected beam wander. This new theory is validated by demonstrating excellent agreement between the predicted scintillation index and computer code results for both tracked and untracked beams. For many applications of practical interest, such as free-space optical communications, a good understanding of the time-average Strehl ratio is also essential simulation results for this parameter are presented and shown to be in good agreement with the theory.
Yearning for the Unattainable: A Comparison of Jussi Biorling's Four Recorded Performances of Beethoven's "Adelaide" (2001)

1f you w.mt a lifetime companion of the feathered variety, all you have to do is show up when a duckling hatches. By a neural process known as "imprinting," the baby bird will bond to and faithfully follow the first object it sees- whether it's mama duck, a human, or even the family dog- upon emerging from its shell. Perhaps you have had a similar experience with a favorite piece of music: you became "imprinted' by the first performance you were exposed to, to such an extent that it subconsciously became the standard by which you judge all others. In my case, a first exposure to Beethoven's "Adelaide" (and to JB) was via a CD of his 1958 Carnegie Hall concert. Having fallen in love with this miraculous voice, I soon thereafter purchased the four-CD EMl set through which I discovered JB's 1939 version of the song. But what a difference! Compared to the 1958 performance, this rendition sounded to my ears somewhat sentimental and overwrought. Had I, like the baby duckling, simply become "imprinted" by the first version I was exposed to, irrationally preferring it to all others? Or was my musical intuition correct in telling me chat the 1958 performance was, indeed, superior? Were there intermediary interpretations in the years between the two performances? These were the questions I decided to explore by investigating the four extant versions of the song in ]B's recorded legacy.
Bioactive Glasses Containing Au Nanoparticles. Effect of Calcination Temperature on Structure, Morphology, and Surface Properties (2010)

Bioactive glasses containing gold nanoparticles (AuNPs) have been synthesized via the sol-gel route using HAuCl(4) x 3 H(2)O as gold precursor. The formation process of AuNPs was studied as a function of the thermal treatment, which induces nucleation of Au particles and influences their nature, optical properties, shape, size, and distribution. The physicochemical characterization indicates that the sample treated at 600 degrees C presents the best characteristics to be used as a bioactive material, namely high surface area, high amount of AuNPs located at the glass surface, presence of micropores, and abundant surface OH groups. In the case of samples either aged at 60 degrees C or calcined at 150 degrees C, AuNPs just begin their formation, and at this stage the gel is not completely polymerized and dried yet. A thermal treatment at higher temperatures (900 degrees C) causes the aggregation of AuNPs, forming "AuMPs" (i.e., Au microparticles) in a densified glass-ceramic material with low surface area, absence of pores, and low number of surface OH groups. These features induce in the glass-ceramic materials treated at high-temperatures a lower bioactivity (evidenced by SBF reaction), as compared with that exhibited by the glass samples treated at 600 degrees C.
Diffusion gradient plates for herbicide toxicity tests on micro-algae and cyanobacteria (1988)

Single dimension agar gel diffusion gradient plates were used to test the tolerance of several micro-algae and cyanobacteria to five herbicides. Growth of most of the test organisms was prevented by terbutryn and diuron at concentrations between 1·1 and 2·8 μg/ml (minimum inhibitory concentration, MIC). Chlorpropham was intermediate in toxicity whilst monuron and atrazine generally gave higher MIC values (up to 17·1 μg/ml). The cyanobacteria were mostly more tolerant than the algae, but susceptibility to the herbicides was variable even between strains of an individual algal species. The gradient plate technique offers the advantages of simplicity and low cost in toxicity screening studies with herbicides or other biologically active chemicals and xenobiotics.
Configurable timing controller design for active matrix electrophoretic display (2009)

To design various electronic papers, the panel designers may adopt different types of electrophoretic materials and active matrix backplanes for resolution, speed, and contrast ratio considerations. The electrical and optical characteristics are quite different under different design requirements so that a good display timing controller should provide an easy way to modify waveforms accordingly. In this paper, we present a configurable timing controller for active matrix electrophoretic displays (EPD). The design principle of driving waveforms is first discussed and the controller can support all variations of driving waveforms with pulse width modulation. The performance of the controller has been verified by several practical EPD systems.
Peanut‐ and cow's milk‐specific IgE, Th2 cells and local anaphylactic reaction are induced in Balb/c mice orally sensitized with cholera toxin (2005)

In contrast with previous authors, Balb/c mice were sensitized and evidenced an allergic reaction after oral administrations of peanut or CMP plus CT, providing an interesting model for further studies on immunopathogenic mechanisms.
Similarities in Sexual Activity and Condom Use among Friends within Groups before and after a Risk-Reduction Intervention (1998)

One promising avenue for augmenting the effect of interventions designed to reduce risk behaviors for acquisition of the human immunodeficiency virus (HIV) among adolescents is the use of peer influence through friendship groups. In this study, conducted among 76 groups of African American adolescents, the authors sought to determine whether the similarity of behaviors among group members persists over time and whether the similarity is enhanced through a risk-reduction intervention. Youth within groups were more similar compared to youth between groups with respect to sexual behaviors, expectations, and feelings at the baseline and through 18 months of follow-up. An HIV risk-reduction intervention that increased condom use also increased similarity of condom use among youth within intervention groups at 6 and 18 months postintervention. These data provide empiric support for the hypothesis that delivery of HIV-prevention efforts through groups of friends may be a useful intervention adjunct.
Aerodynamic Concept for Very Large Steam Turbine Last Stages (2005)

A move to ever larger low pressure steam turbines inevitably leads to an increase in the blade height to hub diameter ratio and the extent and magnitude of supersonic flow. This paper looks at the options available to the designer to mitigate the aerodynamic challenges associated with an increase in turbine size. Combinations of the effects of lean and sweep are explained using simple arguments based on flow field streamlines, then demonstrated in a stationary blade design by numerical and experimental methods. Developments in the principal regions of transonic and supersonic flow are shown by stationary blade hub and rotating blade tip examples. A stationary blade design which optimises the flow field effects shown is presented. The paper concludes by evaluating the unsteady flow in a very large final stage design.
Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins. (1988)

The glucagon gene is expressed specifically in the alpha cells of the pancreatic islets. We show here that 300 base pairs of the 5'-flanking region of the rat glucagon gene, linked to a chloramphenicol acetyltransferase reporter plasmid transfected into islet cell lines of different hormone-producing phenotypes, directs transcription only in glucagon-producing islet cells. Deletional and linker-scanning mutations and DNase I footprinting assays identify three transcriptional control elements within these 300 base pairs. Two of these elements (G2 and G3) independently display enhancerlike functions on both homologous and heterologous promoters in glucagon (alpha) cells, but only on heterologous promoters in insulin- (beta) and somatostatin- (delta) expressing cells, and not in non-islet cells. The proximal promoter element (G1), characterized by low intrinsic transcriptional activity, is critical for specific expression of the glucagon gene in alpha cells. However, nuclear extracts prepared from all three islet cell phenotypes give similar protection to the three control elements of the glucagon 5'-flanking sequence. We conclude that these phenotypically distinct islet cell lines all contain regulatory DNA-binding proteins interacting with the three control elements of the glucagon gene, but that factors interacting with the glucagon promoter result in transcriptional activation only in alpha cells, to restrict glucagon gene expression to these cells. These observations suggest that interactions of nuclear proteins with cis-control elements are involved in the programmed developmental expression of the islet polypeptide hormone genes.
Rapid characterization of covalent modifications to rat brain mitochondrial proteins after ex vivo exposure to 4‐hydroxy‐2‐nonenal by liquid chromatography–tandem mass spectrometry using data‐dependent and neutral loss‐driven MS<sup>3</sup> acquisition (2007)

The modification of mitochondrial proteins enriched from rat forebrain by the major lipid peroxidation product 4-hydroxy-2-nonenal (HNE) was investigated using high performance liquid chromatography (HPLC) and tandem mass spectrometry. Subcellular fractionation in conjunction with a 'shotgun-based' approach that involved both conventional data-dependent and neutral loss (NL)-driven MS(3) data acquisition on a hybrid linear ion trap-Fourier transform ion cyclotron resonance mass spectrometer (LTQ-FT) was utilized. Using a relatively rapid linear HPLC gradient (1 h) for complex mixture analysis, 24 sites of HNE modification on 15 unique proteins were identified which corresponded exclusively to Michael adduct formation on histidine residues. Since a number of HNE-modified peptides produced a predominant HNE NL fragment-ion signal upon collision-induced dissociation (CID), NL-driven MS(3) data-dependent acquisition was a valuable method to enhance fragmentation information for these particular modified peptides. Of the 24 HNE modification sites identified, approximately 25% were determined from the MS(3) spectra alone. We envision the reported methodology as an efficient screening approach for HNE modification site selectivity that could ultimately provide a foundation for the development of targeted schemes for the characterization of in vivo HNE-protein adducts.
Production of high yields of docosahexaenoic acid by <i>Schizochytrium</i> sp. strain SR21 (1997)

Abstract The culture conditions for high‐yield production of docosahexaenoic acid (DHA) by Schizochytrium sp. strain SR21 were investigated in a fermenter. With increasing carbon (glucose) and nitrogen (corn steep liquor and ammonium sulfate) sources (up to 12% glucose) in the medium, DHA productivity increased without a decrease in growth rate, i.e., 2.0, 2.7, and 3.3 g DHA/L/d with 6, 10, and 12% glucose, respectively. Eventually, 48.1 g dry cells/L and 13.3 g DHA/L were produced in 4 d with 12% glucose. DHA productivity was decreased with 15% glucose, i.e., 3.1 g/L/d. With 12% glucose, the lipid content was 77.5% of dry cells, and DHA content was 35.6% of total fatty acids. The lipid was composed of about 95% neutral lipid and 5% polar lipid. In polar lipids, the contents of phosphatidylcholine (PC), phosphatidylethanolamine, and phosphatidylinositol were 74, 11, and 5%, respectively. The PC profile was simple, 70% of PC molecules were 1‐palmitoyl‐2‐DHA‐PC and 1.2‐di‐DHA‐PC. These results indicate that Schizochytrium sp. strain 21 is an excellent source for microbial DHA production, including not only the acid form of DHA but also 2‐DHA‐PC.
Dynamic Modeling of Passively Draining Structures for Aerial–Aquatic Unmanned Vehicles (2019)

In the design of hybrid unmanned aerial and underwater vehicles, buoyancy management and weight are two major factors. Large wing volumes used by unmanned air vehicles to fly efficiently drive vehicle buoyancy up, preventing them from submerging. Heavy active buoyancy control systems can overcome this, but cost weight, energy, and time to transition between underwater operation and flight. An alternative design, consisting of a passively flooding and draining wing, is presented in this paper. Relevant dynamic parameters for a full vehicle dynamic model are identified. A dynamic model of a draining structure is developed and verified experimentally on both a simple cylinder and a full wing structure. With proper tuning, the model captures the salient dynamic behavior of passive draining during vehicle egress. A prototype unmanned aerial and underwater vehicle was built, flown, and used to collect flight test data. The model is used to accurately predict the takeoff performance of the vehicle. As given, the model can be incorporated into a full vehicle dynamic model to aid in the design, simulation, and control of hybrid unmanned aerial and underwater vehicles with passively draining components.
Serodiagnosis of Leishmaniasis (1995)

Leishmaniasis is a spectrum of diseases ranging in severity from cutaneous (CL), post-kala-azar dermal (PKDL), and diffuse cutaneous (DCL) to mucocutaneous (MCL) and visceral (VL) infections that are endemic in 86 tropical and subtropical countries around the world, accounting for 75,000 deaths per year. Different forms of leishmaniases are generally caused by different distinct species of Leishmania having a digenetic life cycle alternating between an aflagellated amastigote form replicative within the macrophages of the host and a flagellated promastigote form that multiplies within the gut of the sandfly. VL, MCL, PKDL, DCL, and CL forms of the disease can be arranged on a priority basis in accordance with the humoral immune responses of host. Generally, the cell-mediated immunity, particularly the delayed-type hypersensitivity to leishmanial antigens, is associated with CL, MCL, PKDL, and cured VL cases. The serodiagnosis of leishmaniasis appears to be an alternative to parasite detection in biopsy samples either by the staining of amastigotes or by culturing the amastigotes, which transform to a promastigote form and replicate. A battery of immunological procedures have been developed or adapted to demonstrate either humoral or cell-mediated immune responses against Leishmania for diagnosis and epidemiological survey. The sensitivity and specificity of such diagnostic methods depend on the type, source, and purity of antigen employed, as some of the leishmanial antigens have common cross-reactive epitopes shared with other microorganisms, particularly Trypanosoma, Mycobacteria, Plasmodia, and Schistosoma. Serodiagnostic techniques for the detection of antileishmanial antibodies have been employed with about 72 to 100, 23 to 90, 83, and 33 to 100% success in VL, CL, MCL, and PKDL patients, respectively. The Leishmanin skin test (LST) is useful to detect MCL and CL, with about 100 and 84% success, respectively. In PKDL, the gradual fall of antileishmanial antibody titer to some extent and the rise of delayed hypersensitivity to the parasite antigen are the characteristic features associated with the chronicity of the disease. The use of whole promastigote as the source of antigens in the direct agglutination test (DAT) and immunofluorescent test (IFAT) gave cross-reactions with the sera of leprosy, tuberculosis, and African trypanosomiasis patients. Again, the use of cell-free extracts of promastigotes generally gave false positive results with the sera of normal human and Chagas' disease, leprosy, tuberculosis, and malaria patients in enzyme-linked immunosorbent assay (ELISA), dot ELISA, immunodiffusion, immunoelectrophoresis, and counter-current immunoelectrophoresis tests.(ABSTRACT TRUNCATED AT 400 WORDS)
End to End Deep Neural Networks Radio Receiver for Speech Signals. (2017)

End-to-end learning based approaches have been shown to be effective and are giving excellent performance for many systems with less training data. In this work we present an end to end learning approach for novel application of software defined radio (SDR) that utilizes the prior knowledge of transmitted speech message to detect and denoise the audio speech signal from the in-phase and quadrature components of its base band version.
A Centralized Hybrid MAC Protocol for Wireless Sensor Networks (2007)

A centralized hybrid MAC protocol for wireless sensor networks (WSNs) is proposed, where the design objective is to be able to provide reliable quality of services (QoS) control, high throughput, and scalability to networks by utilizing a priority-based hybrid time-coordinated contention and contention-free medium access control (MAC) protocol. The proposed protocol's resource reservation scheme can provide guarantee throughout access for selected users even under extremely emergent high demand situations, and applies a periodic shutdown scheme for low-power consumption.