gebhart/patrepeval huggingface dataset:
Hepatic artery embolization in the treatment of hepatic neoplasms. (1981)

Seventy-two hepatic artery embolizations were performed in 47 patients to treat hepatic neoplasms. Hepatic artery embolization creates tumor devascularization, but the portal flow prevents infarction of liver parenchyma because of the single vascular supply from the hepatic artery to a neoplasm, in contrast to the dual vascular supply to the liver parenchyma. Indications for the use of hepatic artery embolization are failure of chemotherapy, either systemic or intra-arterial infusion, vascular anomalies requiring combined lobar embolization and lobar infusion, and lack of effective treatment. Three types of embolization were performed: peripheral embolization using Gelfoam, proximal embolization using coils, and combined peripheral and proximal embolization. The complications after embolization were pain, fever, and transient liver function changes. No death or hepatic abscess occurred. The median survival duration of the group was 11.5 months from the time of embolization. Hepatic artery embolization is an effective treatment of hepatic neoplasm.
A vortex wake model for optimum heavily loaded ducted fans (1970)

Like the free propeller in axial flight, a single-rotation ducted fan of highest induced efficiency is characterized by an ultimate wake vortex system shed from the blade trailing edges whose apparent motion is that of rigid helical surfaces. In addition and concentric with this inner sheet, there is a cylindrical surface of helical vortex filaments shed from the duct trailing edge. For zero hub diameter, and neglecting compressibility, viscosity, and tip clearance, a consistent mathematical model of the constant-diameter vortex wake is developed and the compatibility relationships to be satisfied are presented. Using the Biot-Savart equation, the vortex strength distribution in the wake may be determined by numerical methods and then related to the blade bound vortex strength. Some preliminary results of the analysis are presented for the lightly loaded case for comparison with existing methods.
Compact Modeling of Total Ionizing Dose and Aging Effects in MOS Technologies (2015)

This paper presents a physics-based compact modeling approach that incorporates the impact of total ionizing dose (TID) and stress-induced defects into simulations of metal-oxide-semiconductor (MOS) devices and integrated circuits (ICs). This approach utilizes calculations of surface potential (ψ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> ) to capture the charge contribution from oxide trapped charge and interface traps and to describe their impact on MOS electrostatics and device operating characteristics as a function of ionizing radiation exposure and aging effects. The modeling approach is demonstrated for bulk and silicon-on-insulator (SOI) MOS device. The formulation is verified using TCAD simulations and through the comparison of model calculations and experimental I - V characteristics from irradiated devices. The modeling approach is suitable for simulating TID and aging effects in advanced MOS devices and ICs, and is compatible with modern MOSFET compact modeling techniques. A circuit-level demonstration is given for TID and aging effects in SRAM cells.
Factors Determining the Efficacy of Nuclear Delivery of Antisense Oligonucleotides by Gold Nanoparticles (2008)

The present study investigates the applicability of nanoparticle delivery vectors for two-stage targeting that involves both cell entry by endocytosis and nuclear targeting using viral peptide signals. A nanoparticle vector consists of four components: a carrier nanoparticle, a stabilizer, targeting peptides, and a therapeutic cargo. Extensive study of bovine serum albumin (BSA)-peptide stabilized nanoparticle conjugates demonstrated limitations of these systems due to colloidal instability when oligonucleotides and multiple peptides were attached to the BSA protein. We found that the widely used protein streptavidin (SA) was an appropriate alternative to BSA for cell-targeting experiments. Targeting peptides and gene splicing oligonucleotides were attached to SA-nanoparticles using biotin labels. The present study uses a gene-splicing assay as a test for oligonucleotide delivery to the cell nucleus. Successful modification of gene splicing by an antisense oligonucleotide indicates that the latter must have crossed the plasma membrane, entered the nucleus, found the target sequence in the newly transcribed pre-mRNA, and hybridized to it in the spliceosome strongly enough to displace the splicing factors designed to interact with the target sequence. Targeting nanoparticles that carry gene-splicing oligonucleotides were compared with a control experiment that used lipofectamine (LF). While enhanced activity was observed in the control experiment, in the presence of LF, no gene splicing was observed for the nanoparticle targeting vectors without LF. We conclude that sequestration of cargo from the harsh conditions of the endosome is a desirable strategy for cell-targeting nanoparticles.
Automation of &#x201C;ground truth&#x201D; annotation for multi-view RGB-D object instance recognition datasets (2014)

Aiming at reducing the labour intensity associated with the acquisition of ground truth annotations for object instance recognition datasets, this paper discusses a novel multi-view recognition method to automate the annotation (object instances and associated poses) of individual images in multi-view RGB-D datasets. In combination with recent single-view object recognition techniques, the supplementary information provided by multiple vantage points results in a rich and integrated representation of the environment, in the form of a 3D reconstructed scene as well as object hypotheses therein. We argue that such a representation facilitates improved recognition to an extent that the recovered results, obtained by means of a suitable 3D hypotheses verification stage, closely resemble the ground truth of the scene under consideration. On two large datasets, totalling more than 3500 object instances, our method yields 99.1% and 93.2% correct automatic annotations. These results corroborate our approach for the task at hand.
REVIEWS OF BOOKS (1990)

REVIEWS OF BOOKS Get access The Lost Chord: Essays on Victorian Music. Ed. by Nicholas Temperley . pp. x + 180. ( Indiana University Press, Bloomington & Indianapolis, 1989, $35. ISBN 0-253-33518-3/ 0-253-33519-1 (accompanying cassette).) PERCY M. YOUNG PERCY M. YOUNG Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume 71, Issue 3, August 1990, Pages 415-b–418, https://doi.org/10.1093/ml/71.3.415-b Published: 01 August 1990
An empirical evaluation of option pricing in intellectual capital (2003)

The investments in intellectual capital by firms in the knowledge economy are a critical driver for growth, profitability and competitiveness. This paper reviews the basic option‐pricing models for pricing financial instruments and evaluates their characteristics in relation to their applicability to intellectual property, focusing on two distinct characteristics, i.e. past decisions that influence future technological options, and the inherent uncertainty over future innovation opportunities. The findings in this study include the discovery and confirmation of certain financial characteristics that are important for the successful implementation of the option‐pricing methodology in high technology financial planning and management. This paper attempts to summarise the current strand of literature pertaining to the use of option pricing in the intellectual capital‐intensive sector by evaluating their strengths and weaknesses, and make recommendations as to how they can be effectively addressed to produce better results in the valuation process.
Modified Wideband Marchand Balun With Tunable Power Division Ratio and Constant Phase (2016)

A balun with a wide tunable power division ratio and constant phase across a wide frequency band is presented. The proposed design is a modification of the traditional Marchand balun with a varactor and series resistor loaded at the central point of the two connected pairs of coupled lines. The varactor is used to control the power division ratio at two output ports, whereas the resistor is used to stabilize the power division across a wide operational bandwidth. The achievable power division ratio and differential phase are investigated for different band ranges. A prototype is designed, fabricated, and tested. The results indicate a tuning power ratio range from 1:1 to 3.5:1 across 80% fractional bandwidth (1.2-2.8 GHz) with more than 10 dB return loss and less than 9° differential phase.
Inter-Basket and Intra-Basket Adaptive Attention Network for Next Basket Recommendation (2019)

Next basket recommendation with consideration of user sequential shopping behaviors plays a significant role in E-commerce to improve the user experience and service quality. Recently, recurrent neural networks (RNNs), especially attention-based RNN, have been widely adopted in the next basket recommendation. However, existing fixed attention mechanisms are not designed to model the dynamic and diverse characteristics of user appetites. In this paper, we propose an inter-basket and intra-basket adaptive attention network (IIAAN) for the next basket recommendation. Specifically, the inter-basket adaptive attention acts on all historical user baskets to model user's diverse long-term preferences, while the intra-basket adaptive attention is designed to act on item-level in the most recent basket to model user's dynamic and different short-term preferences. Then, we further integrate inter-basket and intra-basket adaptive attentions together to improve recommendation effectiveness. Finally, we evaluate the proposed model IIAAN using three real-world datasets from various E-commerce platforms. Our experimental results show that our model IIAAN significantly outperforms the state-of-the-art approaches for the next basket recommendation.
Oral Immunization against PEDV with Recombinant Lactobacillus casei Expressing Dendritic Cell-Targeting Peptide Fusing COE Protein of PEDV in Piglets (2018)

Porcine epidemic diarrhea (PED) is a highly contagious disease in newborn piglets. In our previous study, a genetically engineered <i>Lactobacillus casei</i> oral vaccine (<i>pPG-COE-DCpep/L393</i>) expressing a dendritic cell (DC)-targeting peptide fused with porcine epidemic diarrhea virus (PEDV) COE antigen was developed. This vaccine induced significant levels of anti-PEDV specific IgG and IgA antibody responses in mice, indicating a potential strategy against PEDV infection. In this study, <i>pPG-COE-DCpep/L393</i> was used for oral vaccination of newborn piglets against PEDV. We then assessed the immune responses and protection efficacy of <i>pPG-COE-DCpep/L393</i>. An indirect enzyme-linked immunosorbent assay (ELISA) showed that the recombinant <i>Lactobacillus</i> vaccine elicits a specific systemic and mucosal immune response. The T-helper cells mediated by <i>pPG-COE-DCpep/L393</i> and PEDV infection display a Th1 phenotype. The histopathological results showed that <i>pPG-COE-DCpep/L393</i> promotes lymphocyte proliferation and effectively protects piglets against PEDV infection. The transforming growth factor-β level indicated that the recombinant <i>Lactobacillus</i> vaccine plays a role in anti-inflammatory responses in mesenteric lymph nodes during PEDV infection. These results show that <i>pPG-COE-DCpep/L393</i> is a potential vaccine against PEDV infection.
A Versatile Drop Test Procedure for the Simulation of Impact Environments (1961)

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Degradation of highly chlorinated PCBs byPseudomonas strain LB400 (1986)

Congeners of polychlorinated biphenyl (PCB) differ in the number and position of chlorine substituents. Although PCBs are degraded, those congoners with five or more chlorines have been considered resistant to bacterial degradation. Metabolism byPseudomonas strain LB400 of PCBs representing a broad spectrum of chlorination patterns and having from two to six chlorines was investigated. Degradation of pure PCB congeners and synthetic congener mixes was measured in resting cell assays with biphenyl- or Luria broth-grown cells. In addition, the appearance of metabolites was followed using HPLC purification, and GC and GC-MS characterization. 2,4,5,2′,4′,5′-[14C]hexachlorobiphenyl was also used to follow the accumulation of14C-labeled metabolites. Evidence indicates that LB400 aerobically metabolizes representatives of all major structural classes of PCB's including several congeners which lack adjacent unchlorinated carbon atoms. The mechanisms by which many of these congeners are degraded are not fully understood, but it is apparent that aerobic bacteria can degrade a broader spectrum of PCB congeners than previously believed and that this broad spectrum of degradative competence can exist in a single strain.
A High Performance Tactical 3-D Radar for the 1980's (1982)

System design aspects of the Westinghouse TPS-70(V)X radar under current development are described.
Squalene, Olive Oil, and Cancer Risk: Review and Hypothesis (1999)

Epidemiologic studies of breast and pancreatic cancer in several Mediterranean populations have demonstrated that increased dietary intake of olive oil is associated with a small decreased risk, or no increased risk, of cancer, despite a high overall lipid intake. Experimental animal models in high dietary fat and cancer also indicate that olive oil either has no effect, or a protective effect, on the prevention of a variety of chemically induced tumors. As a working hypothesis, it is proposed that the high squalene content of olive oil, as compared to other human foods, is a major factor in the cancer-risk reducing effect of olive oil. Experiments in animal models suggest a tumor-inhibiting role for squalene. A mechanism is proposed for the tumor-inhibitory activity of squalene based on its known strong inhibitory activity of HMG-COA reductase catalytic activity in vivo, thus reducing farnesyl pyrophosphate (FPP) availability for "prenylation" of ras oncogene, which relocates this oncogene to cell membranes and is required for the signal-transducing function of ras. Reduction of mutated ras oncogene activation may be useful in breast and colon cancer and may be particularly applicable to pancreatic cancers that are strongly associated with ras oncogenes.
Quartz Crystal Microbalance Aptasensor for Sensitive Detection of Mercury(II) Based on Signal Amplification with Gold Nanoparticles (2012)

We show that a short mercury-specific aptamer (MSA) along with gold nanoparticles (Au-NPs) can be used to determine Hg(II) ion by a combination of a QCM-based sensor and a flow system. The MSA binds specifically to Hg(II), and the Au-NPs can amplify the signal to enhance sensitivity. Specifically, the short thiolated MSAs are immobilized on the surface of the QCM as the capture probe, and the MSAs are linked to the Au-NPs as the linking probe. The two components can form a sandwich structure of the T-Hg(II)-T type in the presence of Hg(II) ions. This leads to change in the mass on the QCM and a change in the resonance frequency. Hg(II) can be determined with a detection limit of 0.24 ± 0.06 nM which is better by three orders of magnitude than previous methods. The sensor can be regenerated by disrupting the T-Hg(II)-T base pairs with a solution of cysteine.
Self-regulating composite bearingless wind turbine (1976)

Abstract The Composite Bearingless Rotor (CBR) concept has been shown to have characteristics ideally suited for wind turbine applications. Originally developed for helicopters to reduce weight, costs and complexity, the CBR eliminates blade bearings and hinges through the utilization of the unique structural characteristics of uniaxial composite materials. This rotor concept was further developed under an ERDA contract to provide a fully self-regulating and self-aligning wind turbine. Such a system was achieved without the need for auxiliary controls or sensors. These features allow self-starting for wind initiating from any direction and automatic pitch and yaw variations to optimize performance under all normal wind conditions. The work described in this report consists of the design and fabrication of a 4.5 ft dynamically scaled wind turbine model and the successful testing of this model in the United Technologies Research Center low speed wind tunnel.
Fast global optimization of curvature (2010)

Two challenges in computer vision are to accommodate noisy data and missing data. Many problems in computer vision, such as segmentation, filtering, stereo, reconstruction, inpainting and optical flow seek solutions that match the data while satisfying an additional regularization, such as total variation or boundary length. A regularization which has received less attention is to minimize the curvature of the solution. One reason why this regularization has received less attention is due to the difficulty in finding an optimal solution to this image model, since many existing methods are complicated, slow and/or provide a suboptimal solution. Following the recent progress of Schoenemann et al., we provide a simple formulation of curvature regularization which admits a fast optimization which gives globally optimal solutions in practice. We demonstrate the effectiveness of this method by applying this curvature regularization to image segmentation.
Oil Press for Food Oil and Biomass Production (2011)

In this study, first, rapeseed was separated the high quality seed for food oil and the low quality seed for biofuels. Next, laboratory-scale oilseed screw press was used to investigate the effects of choke opening and seed preheating on these rapeseed pressing performance and quality of food oil and biofuels oil. Maximum pressure increased, oil recovery increased, but chlorophyll in rapeseed oil was increased, too. Especially, acid value of the rapeseed oil extracted from low quality seed was high value. For the rapeseed pressing performance, the rapeseed heated by microwaves outputted more oil than that without heating. And the chlorophyll in the rapeseed oil extracted from the rapeseed treated by microwaves was higher than that without heating. The Net Energy Balance ratio of microwave heating press with choke opening set at 8.0 mm is advantage. And the oil pressed this method was good and basically fulfilled the Codex Alimentarius requirements for edible oils.
Molecular cloning and analysis of a pleiotropic regulatory gene locus from the nystatin producer<i>Streptomyces noursei</i>ATCC11455 (1999)

A regulatory gene locus from Streptomyces noursei ATCC14455, the producer of the antifungal antibiotic nystatin, was cloned in Streptomyces lividans based on its ability to activate actinorhodin (Act) production in this host. Deletion and DNA sequencing analyses showed that a small gene, designated ssmA, located downstream of an afsR homologue (a known pleiotropic regulator) was responsible for the Act overproduction in S. lividans. Database searches for the ssmA gene product revealed its limited similarity to the AfsR2 regulatory protein from S. lividans and CREA catabolite repressor from Aspergillus nidulans. To study the effect of ssmA on nystatin production, this gene was either deleted from S. noursei genome, or placed under control of PermE* promoter and introduced in S. noursei. The properties of the corresponding strains indicate that ssmA is involved in regulation of growth and antibiotic production only in the media with certain carbon sources.
Monoclonal antibodies to rabbit progesterone receptor: crossreaction with other mammalian progesterone receptors. (1983)

A mouse was immunized with purified rabbit uterine cytosolic progesterone receptor (specific activity: 3 nmol of steroid bound per mg of protein). After fusion of its spleen cells with Sp2-OAg myeloma cells, supernatants of 11 hybrid cultures were found to react in both an immunoenzymatic test and a double-immunoprecipitation test with the progesterone receptor. Clones were obtained from the five hybrid cells that gave the strongest response in both tests. Antibodies from cell culture supernatants and ascitic fluids were characterized. Three are of the IgG1 and two of the IgG2a isotype. Their apparent affinity for the progesterone receptor was measured by immunoprecipitation in physiological salt conditions. The equilibrium dissociation constants were between 0.1 and 4 nM. All five monoclonal antibodies crossreacted with the rabbit nuclear receptor, the human cytosolic receptor, and other mammalian (rat, guinea pig) but not avian (chicken) cytosolic progesterone receptors. There was no interaction with the glucocorticoid receptor and corticosteroid binding globulin.
Advanced Semiconductor Technology for Alternate Energy Sources - D-C to A-C Inverters, (1977)

Alternate or advanced energy conversion methods frequently require d-c to a-c conversion since the energy output must be synchronized with an existing utility grid. The objective of this paper is to describe various preliminary system concepts for interfacing advanced solid-state energy converters to the utility grid with a significant potential for reducing initial capital investment. Recent ERDA sponsored studies have identified the solid-state d-c to a-c inverter as a key element for further development. These studies indicated that an inverter synchronized to the utility grid can directly transform solar photovoltaic array generated energy to local load (residence) demand with any excess energy feedback to the utility grid. Where the solar energy is insufficient to supply the local load, it is supplemented by the utility grid. Several key issues were identified in the referenced studies. One of these involved the considerable weight and cost associated with the d-c to a-c Inverter/Transformer vs a Transformerless Inverter that would have 'Float' with respect to the power grid return. This paper addresses this issue as well as the anticipated solution to the problem using advanced semiconductor technology.
Comparative study of side-wall roughness effects on leakage currents in through-silicon via interconnects (2012)

Influence of the sidewall roughness in through-silicon via (TSV) on leakage currents has been studied. Micro steps along the sidewall, so-called scalloping, formed by Bosch etching, are strongly related to leakage currents between adjacent TSVs. Microcracks in the SiON barriers were observed by TEM analysis and correlated with the sidewall roughness. FEM simulations of the stress concentration along the sidewall roughness clarified the origin of cracking. A non-Bosch etching process showed smooth sidewall surface and we consider it to be feasible for reliable TSV interconnects.