gebhart/patrepeval huggingface dataset:
Survival Analysis, Software (2005)

Abstract Statistical software for survival analysis is discussed. We examine the abilities of five major software packages, BMDP, SAS, SPSS, S‐PLUS, and STATA to perform basic calculations for censored data. Packages are compared based on their performance in computing summary statistics, in hypothesis testing, in performing Cox semiparametric regression modeling, and in performing parametric regression modeling.
Dissociation of yeast nucleoprotein complexes by chemical phosphorylation (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDissociation of yeast nucleoprotein complexes by chemical phosphorylationSrinivasan Damodaran and John E. KinsellaCite this: J. Agric. Food Chem. 1984, 32, 5, 1030–1032Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/jf00125a021https://doi.org/10.1021/jf00125a021research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Trifluorophosphine Complexes of Transition Metals (1967)

Abstract The present paper deals with a new class of inorganic coordination compounds, the first member of which, tetrakis(trifluorophosphine)nickel(0), was discovered in 1951. Not only have the neutral metal(0) trifluorophosphines been prepared, but also a number of their derivatives (trifluorophosphinemetal hydrides and trifluorophosphinemetallates, as well as nitrosyl, carbonyl, halogeno, and aromatic trifluorophosphine complexes). These compounds have been characterized by their chemical behavior and by spectroscopic and magnetochemical studies. Trifluorophosphine has the strongest π‐acceptor properties of all neutral ligands, and is therefore particularly suitable for the stabilization of unusually low oxidation states (zero and negative) of transition metals.
Hydrotris(3-mesitylpyrazol-1-yl)borate and hydrobis(3-mesitylpyrazol-1-yl)(5-mesitylpyrazol-1-yl)borate: symmetric and asymmetric ligands with rotationally restricted aryl substituents (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrotris(3-mesitylpyrazol-1-yl)borate and hydrobis(3-mesitylpyrazol-1-yl)(5-mesitylpyrazol-1-yl)borate: symmetric and asymmetric ligands with rotationally restricted aryl substituentsArnold L. Rheingold, Corbet B. White, and Swiatoslaw TrofimenkoCite this: Inorg. Chem. 1993, 32, 16, 3471–3477Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ic00068a015https://doi.org/10.1021/ic00068a015research-articleACS PublicationsRequest reuse permissionsArticle Views824Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases (2014)

Tumor-induced immunosuppression remains one of the major obstacles to many potentially effective cancer therapies and vaccines. Host interleukin (IL)-23 suppresses the immune response during tumor initiation, growth, and metastases, and neutralization of IL-23 causes IL-12-dependent antitumor effects. Here, we report that combining agonistic anti-CD40 monoclonal antibodies (mAb) to drive IL-12 production and anti-IL-23 mAbs to counter the tumor promoting effects of IL-23 has greater antitumor activity than either agent alone. This increased antitumor efficacy was observed in several experimental and spontaneous lung metastases models as well as in models of de novo carcinogenesis. The combination effects were dependent on host IL-12, perforin, IFN-γ, natural killer, and/or T cells and independent of host B cells and IFN-αβ sensitivity. Interestingly, in the experimental lung metastases tumor models, we observed that intracellular IL-23 production was specifically restricted to MHC-II(hi)CD11c(+)CD11b(+) cells. Furthermore, an increase in proportion of these IL-23-producing cells was detected only in tumor models where IL-23 neutralization was therapeutic. Overall, these data suggest the clinical potential of using anti-CD40 (push) and anti-IL-23 mAbs (pull) to tip the IL-12/23 balance in established tumors.
VII. On a method of investigating periodicities disturbed series, with special reference to Wolfer's sunspot numbers (1927)

Abstract If we take a curve representing a simple harmonic function of the time, and superpose on the ordinates small random errors, the only effect is to make the graph somewhat irregular, leaving the suggestion of periodicity still quite clear to the eye. Fig. 1 (a) shows such a curve, the random errors having been determined by the throws of dice. If the errors are increased in magnitude, as in fig. 1 (b), the graph becomes more irregular, the suggestion of periodicity more obscure, and we have only sufficiently to increase the “errors” to mask completely any appearance of periodicity. But, however large the errors, periodogram analysis is applicable to such a curve, and, given a sufficient number of periods, should yield a close approximation to the period and amplitude of the underlying harmonic function. When periodogram analysis is applied to data respecting any physical phenomenon in the expectation of eliciting one or more true periodicities, there is usually, as it seems to me, a tendency to start from the initial hypothesis that the periodicity or periodicities are masked solely by such more or less random superposed fluctuations— fluctuations which do not in any way disturb the steady course of the underlying periodic function or functions. It is true that the periodogram itself will indicate the truth or otherwise of the hypothesis made, but there seems no reason for assuming it to be the hypothesis most likely a priori.
On the Equivalence of the KMV and Maximum Likelihood Methods for Structural Credit Risk Models (2005)

Moody’s KMV method is a popular commercial implementation of the structural credit risk model pioneered by Merton (1974). It is an algorithm for estimating the unobserved asset value and the unknown parameters required for implementing such a model. This estimation method has found its way to the recent academic literature, but it has not yet been formally analyzed to assess its statistical properties. This paper fllls this gap and shows that, in the context of Merton’s model, the KMV estimates are identical to maximum likelihood estimates (MLE) developed in Duan (1994). Unlike the MLE method, however, the KMV algorithm is silent about the distributional properties of the estimates and thus ill-suited for statistical inference. The KMV algorithm also cannot generate estimates for capital-structure speciflc parameters. In contrast, the MLE approach is ∞exible and can be readily applied to difierent structural credit risk models.
Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI (2017)

Coronary revascularization guided by iFR was noninferior to revascularization guided by FFR with respect to the risk of major adverse cardiac events at 1 year. The rate of adverse procedural signs and symptoms was lower and the procedural time was shorter with iFR than with FFR. (Funded by Philips Volcano; DEFINE-FLAIR ClinicalTrials.gov number, NCT02053038 .).
On the evolution of handoff management and network architecture in WiMAX (2007)

Mobility management is an essential element of wireless communications. It is the key to enabling always-on wireless connectivity to mobile users. With the advance of the next generation broadband wireless technologies and different network architecture evolution options, the capability to achieve fast and seamless handoff is a critical factor in evaluating the success of a new technology and the efficiency of the network architecture. This paper addresses the possible handoff solutions to new broadband wireless technologies such as WiMAX under different network architectures. The key handoff issues, challenges and architectural options faced in designing the WiMAX networks are discussed
DSD-1-Proteoglycan Is the Mouse Homolog of Phosphacan and Displays Opposing Effects on Neurite Outgrowth Dependent on Neuronal Lineage (1999)

DSD-1-PG is a chondroitin sulfate proteoglycan (CSPG) expressed by glial cells that can promote neurite outgrowth from rat embryonic mesencephalic (E14) and hippocampal (E18) neurons, an activity that is associated with the CS glycosaminoglycans (GAGs). Further characterization of DSD-1-PG has included sequencing of peptides from the core protein and the cloning of the corresponding cDNA using polyclonal antisera against DSD-1-PG to screen phage expression libraries. On the basis of these studies we have identified DSD-1-PG as the mouse homolog of phosphacan, a neural rat CSPG. Monoclonal antibodies 3H1 and 3F8 against carbohydrate residues on rat phosphacan recognize these epitopes on DSD-1-PG. The epitopes of the antibodies, L2/HNK-1 and L5/Lewis-X, which have been implicated in functional interactions, are also found on DSD-1-PG. Although DSD-1-PG has previously been shown to promote neurite outgrowth, its upregulation after stab wounding of the CNS and its localization in regions that are considered boundaries to axonal extension suggested that it may also have inhibitory functions. Neonatal dorsal root ganglion (DRG) explants grown on a rich supportive substrate (laminin) with and without DSD-1-PG were strikingly inhibited by the proteoglycan. The inhibitory effects of DSD-1-PG on the DRG explants were not relieved by removal of the CS GAGs, indicating that this activity is associated with the core glycoprotein. The neurite outgrowth from embryonic hippocampal neurons on laminin was not affected by the addition of DSD-1-PG. This indicates that DSD-1-PG/mouse phosphacan can have opposing effects on the process of neurite outgrowth dependent on neuronal lineage.
Long-Term Lumbar Facet Joint Changes in Spinal Fracture Patients Treated with Harrington Rods (1990)

Reports in the literature have questioned the practice of using Harrington distraction rods spanning unfused spinal segments for internal fixation of the fractured thoracolumbar spine. However, the long-term incidence of facet joint osteoarthritis has not been reported. This is the report on a retrospective analysis of 20 of these patients with an average follow-up period of 8.0 years. Eighty-five percent of the patients received a classification of good to excellent regarding back pain and 90% returned to their preinjury occupation. Of significance, of 75 lumbar facets traversed by rods but not fused, only two were classified as “closed” or autofused. It remains to be seen if some pedicular systems are superior to this technique in trained hands. However, multisegmental instrumentation with unisegmental fusion is possible without obtaining the severe osteoarthritic changes that animal studies have demonstrated.
Feature Extraction and Fusion Using Deep Convolutional Neural Networks for Face Detection (2017)

This paper proposes a method that uses feature fusion to represent images better for face detection after feature extraction by deep convolutional neural network (DCNN). First, with Clarifai net and VGG Net‐D (16 layers), we learn features from data, respectively; then we fuse features extracted from the two nets. To obtain more compact feature representation and mitigate computation complexity, we reduce the dimension of the fused features by PCA. Finally, we conduct face classification by SVM classifier for binary classification. In particular, we exploit offset max‐pooling to extract features with sliding window densely, which leads to better matches of faces and detection windows; thus the detection result is more accurate. Experimental results show that our method can detect faces with severe occlusion and large variations in pose and scale. In particular, our method achieves 89.24% recall rate on FDDB and 97.19% average precision on AFW.
Application of the refractometer in the measurement and monitoring of brown stock washing (2015)

Brown stock kraft pulp washing removes soluble impurities from a pulp suspension, recovers cooking chemicals and incinerates organics for energy recovery (steam and electricity generation). The parameters used to describe the performance of washing or its effectiveness fall into two categories: wash loss, which describes the amount of washable compounds in the pulp suspension which could have been removed in washing, and the dilution factor which represents the net amount of water that is added during washing. The performance of brown stock washing has an effect on many sub-processes like evaporation, oxygen delignification, bleaching and waste water treatment. Washing results can have positive or negative effects on these sub-processes. It is important to find the correct optimal operating point for washing, because without effective washing of kraft pulp production is not economically viable.\nThe starting point for this study was to develop a real-time measurement application for brown stock kraft pulp washing by which means it would be possible to measure washable compounds or their sum parameters in the liquid and pulp streams on a laboratory and mill scale. The next step was to study the feasibility of using a real-time refractometer, which measures dissolved dry solids, to measure wash loss and monitor the performance of brown stock washing systematically, and then be able to take control of the process by using the results of enough such measurements. In addition, different washers' operational performance were studied by performing stepwise tests and monitoring the results using refractometers.\nThe results show that refractometer measurement works with enough accuracy under very demanding process conditions to reliably measure liquid and pulp streams' dissolved dry solids. Therefore, reliable wash loss measurement can be undertaken using refractometers, once calibration is carried out for the wood species and the installation's characteristics. By utilising the results from three refractometers' consistency and flow rate measurements, it was possible to create a measurement system able to calculate the effectiveness of a single washer accurately and in real time. These refractometers can also be used to determine a washer's optimal operating point. Adjusting a washer's operation towards more efficient operation succeeded in reducing the amount of wash loss to the oxygen delignification and bleaching stages, increasing the dry solids content to the evaporation stage and thus achieving significant economic savings.\nAs continuation has considered to match the filtrate balances over the washers by using four or at least three real-time measurements. Moreover, utilising the refractometer in bleaching washing and calculating the wash loss effects on the bleaching costs has been considered. The work also involves utilising refractometers for very low concentrations in WWTP.
Calculating nonproportionality of scintillator photon response using measured electron response data (2002)

The photon responses of NaI(Tl), CaF/sub 2/(Eu), and LSO(Ce) have been calculated using electron response data measured with the Compton coincidence technique. Calculated results are shown to be in good agreement with both measured photon response data and previously published photon responses for these various scintillators. By establishing the ability to accurately calculate scintillator photon response, scintillator light yield nonproportionality and geometry effects can be studied without the requirement for experimental measurements. Furthermore, photon responses near the electron shell energies can be characterized with more detail than is possible with experimental methods that rely on the use of multiple gamma-ray and X-ray sources. The dependence of photon response on crystal size and shape is also discussed.
Redetermination of cie standard source C (1983)

Abstract The spectral power distribution of CIE standard source C, originally adopted in 1931, has not been determined in modern times to our knowledge. This measurement has now been carried out using the NBS high‐accuracy reference spectrophotometer. In the 50 years since 1931, improved purity of chemicals and improvements in measurement capability have resulted in disfferences between the experimental spectral power distribution and that tabulated as CIE illuminant C. These differences average 1.8% over the entire wavelength range studied, 350‐770 nm; they average only 0.5% below 630 nm but 4.5% (maximum, 6.7%) above 640 nm, where the power of experimental source C is always higher than that of illuminant C. Despite these discrepancies, the two differ by less than 0.001 in chromaticity coordinates x, y, corresponding to a CIELAB color difference of only 0.2 units (1931 standard observer).
Nucleotide sequence of the regulatory locus controlling expression of bacterial genes for bioluminescence (1987)

Production of light by the marine bacterium Vibrio fischeri and by recombinant hosts containing cloned lux genes is controlled by the density of the culture. Density-dependent regulation of lux gene expression has been shown to require a locus consisting of the luxR and luxI genes and two closely linked divergent promoters. As part of a genetic analysis to understand the regulation of bioluminescence, we have sequenced the region of DNA containing this control circuit. Open reading frames corresponding to luxR and luxI were identified; transcription start sites were defined by S1 nuclease mapping and sequences resembling promoter elements were located.
Using Pinch Gloves(TM) for both Natural and Abstract Interaction Techniques in Virtual Environments (2001)

Usable three-dimensional (3D) interaction techniques are difficult to design, implement, and evaluate. One reason for this is a poor understanding of the advantages and disadvantages of the wide range of 3D input devices, and of the mapping between input devices and interaction techniques. We present an analysis of Pinch Gloves™ and their use as input devices for virtual environments (VEs). We have developed a number of novel and usable interaction techniques for VEs using the gloves, including a menu system, a technique for text input, and a two-handed navigation technique. User studies have indicated the usability and utility of these techniques.
Initiation of Epstein-Barr Virus Lytic Replication Requires Transcription and the Formation of a Stable RNA-DNA Hybrid Molecule at OriLyt (2010)

The genetic elements of herpesvirus origins of lytic replication have been characterized in detail; however, much remains to be elucidated concerning their functional role in replication initiation. In the case of the Epstein-Barr virus (EBV), we have found that in addition to the two well-defined critical elements required for lytic replication (the upstream and downstream essential elements, UEE and DEE), the origin of lytic replication (OriLyt) also requires the presence of a GC-rich RNA in cis. The BHLF1 transcript is similar to the essential K5 transcript identified at the Kaposi's sarcoma-associated herpesvirus OriLyt. We have found that truncation of the BHLF1 transcript or deletion of the TATA box, but not the putative ATG initiation codon, reduce OriLyt function to background levels. By using an antibody specific for RNA-DNA hybrid molecules, we found the BHLF1 RNA stably annealed to its DNA template during the early steps of lytic reactivation. Furthermore, expression of human RNase H1, which degrades RNA in RNA-DNA hybrids, drastically reduces OriLyt-dependent DNA replication as well as recruitment of the viral single-stranded DNA binding protein BALF2 to OriLyt. These studies suggest that a GC-rich OriLyt transcript is an important component of gammaherpesvirus lytic origins and is required for initial strand separation and loading of core replication proteins.
Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon (2012)

Fasudil administered at a single oral dose of 40 mg or 80 mg was not associated with significant benefit in terms of the skin temperature recovery time and the digital blood flow after the cold challenge.
Subject categorization of query terms for exploring Web users' search interests (2002)

Abstract Subject content analysis of Web query terms is essential to understand Web searching interests. Such analysis includes exploring search topics and observing changes in their frequency distributions with time. To provide a basis for in‐depth analysis of users' search interests on a larger scale, this article presents a query categorization approach to automatically classifying Web query terms into broad subject categories. Because a query is short in length and simple in structure, its intended subject(s) of search is difficult to judge. Our approach, therefore, combines the search processes of real‐world search engines to obtain highly ranked Web documents based on each unknown query term. These documents are used to extract cooccurring terms and to create a feature set. An effective ranking function has also been developed to find the most appropriate categories. Three search engine logs in Taiwan were collected and tested. They contained over 5 million queries from different periods of time. The achieved performance is quite encouraging compared with that of human categorization. The experimental results demonstrate that the approach is efficient in dealing with large numbers of queries and adaptable to the dynamic Web environment. Through good integration of human and machine efforts, the frequency distributions of subject categories in response to changes in users' search interests can be systematically observed in real time. The approach has also shown potential for use in various information retrieval applications, and provides a basis for further Web searching studies.