gebhart/patrepeval huggingface dataset:
Role of tropomyosin as a cross-reacting allergen in sensitization to cockroach in patients from Martinique (French Caribbean island) with a respiratory allergy to mite and a food allergy to crab and shrimp. (2007)

Tropomyosin could be the cross-reacting allergen relevant for clinical symptoms to mite, cockroach, shrimp and crab.
Effect of Piperonyl Butoxide on Cell Replication and Xenobiotic Metabolism in the Livers of CD-1 Mice and F344 Rats (1997)

Male CD- 1 mice were fed diets containing 0 (control), 10, 30, 100, and 300 mg/kg/day piperonyl butoxide (PBO) and 0.05% sodium phenobarbital (NaPB) and male F344 rats were fed diets containing 0 (control), 100, 550, 1050, and 1850 mg/kg/day PBO and 0.5% NaPB for periods of 7 and 42 days. In both species PBO and NaPB increased relative liver weight and whereas PBO produced a midzonal (mouse) or periportal/midzonal (rat) hypertrophy, NaPB produced a centrilobular hypertrophy. In the rat, individual cell necrosis was also observed at 42 days after high doses of PBO. Replicative DNA synthesis, assessed as the hepatocyte labeling index following implantation of 7-day osmotic pumps containing 5-bromo-2′-deoxyuridine during Study Days 0–7 and 35–42, was increased in mice given 300 mg/kg/day PBO and NaPB for 7 days and in rats given 550 and 1050 mg/kg/day PBO and NaPB for 7 days and 1050 mg/kg/day PBO for 42 days. While PBO had no effect on body weights in mice, the body weights of rats given 550, 1050, and 1850 mg/kg/day PBO for 42 days were reduced to 92, 89, and 70% of control, respectively. PBO induced microsomal cytochrome P450 content and mixed function oxidase activities in the mouse and rat, although the effects were less marked than those produced by NaPB. In summary, this data demonstrates that PBO can produce liver enlargement in the mouse and the rat which is associated with induction of xenobiotic metabolism, hypertrophy, and hyperplasia. The hepatic effects of PBO in the mouse were similar to but less marked than those produced by NaPB. In the rat high doses of PBO were hepatotoxic and resulted in a marked reduction in body weight Thus while the reported formation of eosinophilic nodules in mouse liver by PBO may occur by a mechanism(s) similar to that of NaPB and other nongenotoxic enzyme inducers, the reported tumor formation in rats at greater than the maximum tolerated dose is most likely associated with marked enzyme induction in conjunction with a regenerative hyperplasia resulting from PBO-induced hepatotoxicity.
Pediatric Dosing of Intravenous Sotalol Based on Body Surface Area in Patients with Arrhythmia (2017)

In a recently published study, we evaluated the efficacy and safety of intravenous sotalol in pediatric patients with incessant tachyarrhythmias and we have found that intravenous sotalol is effective and safe. Our dosing regimen was based on the body weight of the patients. In the US, the recommendation for intravenous sotalol dosing in pediatric patients is based on body surface area (BSA) while taking into consideration the patients' age. The purpose of this paper is to show the correspondence of a body weight-based dosing regimen when expressed for BSA as mg/m<sup>2</sup>. We evaluated the similarity of a body weight-based dose to that calculated based on BSA using the US labeling recommendations. Of the 83 patients, 5 were newborns (age: 0-30 days), 39 infants and toddlers (age: 1-24 month), 26 young children (age: >2-6 years), 11 older children (age: 6-12 years), and 2 adolescents (age: 14 years). Each received a loading dose of 1 mg/kg intravenous sotalol administered over 10 min followed by a maintenance dose of 4.5 mg/kg/day. There was a close correlation between the sotalol loading doses calculated based on body weight and BSA across the entire age range (r = 0.977, p < 0.001). In most of the age groups, the body weight-based loading doses were lower or equal to the BSA-based doses. Only in the adolescents were the body weight-based doses higher. The maintenance doses given in our study were significantly higher than the BSA-based dose in newborns: 75 ± 6 versus 53 ± 8 mg/m<sup>2</sup>, p < 0.05; infants/toddlers: 88 ± 14 versus 77 ± 7 mg/m<sup>2</sup>, p < 0.001; younger children: 113 ± 12 versus 85 mg/m<sup>2</sup>, p < 0.001; older children: 123 ± 16 versus 85 mg/m<sup>2</sup>, p < 0.01; and adolescents 157 ± 30 versus 85.5 mg/m<sup>2</sup>. Despite the rapid administration of the loading dose and the increased maintenance doses, our body weight-based dosing regimen was safe. Only one newborn had significant adverse event (AV block) that resolved spontaneously after discontinuation of the infusion.
Utilization of optical emission endpoint in photomask dry etch processing (2002)

Use of accurate and repeatable endpoint detection during dry etch processing of photomask is very important for obtaining good mask mean-to-target and CD uniformity performance. It was found that the typical laser reflectivity endpoint detecting system used on photomask dry etch systems had several key limitations that caused unnecessary scrap and non-optimum image size performance. Consequently, work to develop and implement use of a more robust optical emission endpoint detection system for chrome dry etch processing of photomask was performed. Initial feasibility studies showed that the emission technique was sensitive enough to monitor pattern loadings on contact and via level masks down to 3 percent pattern coverage. Additional work was performed to further improve this to 1 percent pattern coverage by optimizing the endpoint detection parameters. Comparison studies of mask mean-to-target performance and CD uniformity were performed with the use of optical emission endpoint versus laser endpoint for masks built using TOK IP3600 and ZEP 7000 resist systems. It was found that an improvement in mean-to-target performance and CD uniformity was realized on several types of production masks. In addition, part-to-part endpoint time repeatability was found to be significantly improved with the use of optical emission endpoint.
DARC system: notions of defined and generic substructures. Filiation and coding of FREL substructure (SS) classes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDARC system: notions of defined and generic substructures. Filiation and coding of FREL substructure (SS) classesJacques Emile Dubois, Annick Panaye, and Roger AttiasCite this: J. Chem. Inf. Comput. Sci. 1987, 27, 2, 74–82Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/ci00054a007https://doi.org/10.1021/ci00054a007research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
p38 MAP kinase plays a functional role in UVB‐Induced mouse skin carcinogenesis (2011)

UVB irradiation of epidermal keratinocytes results in the activation of the p38 mitogen-activated protein kinase (MAPK) pathway and subsequently activator protein-1 (AP-1) transcription factor activation and cyclooxygenase-2 (COX-2) expression. AP-1 and COX-2 have been shown to play functional roles in UVB-induced mouse skin carcinogenesis. In this study, the experimental approach was to express a dominant negative p38α MAPK (p38DN) in the epidermis of SKH-1 hairless mice and assess UVB-induced AP-1 activation, COX-2 expression, and the skin carcinogenesis response in these mice compared to wild-type littermates. We observed a significant inhibition of UVB-induced AP-1 activation and COX-2 expression in p38DN transgenic mice, leading to a significant reduction of UVB-induced tumor number and growth compared to wild-type littermates in a chronic UVB skin carcinogenesis model. A potential mechanism for this reduction in tumor number and growth rate is an inhibition of chronic epidermal proliferation, observed as reduced Ki-67 staining in p38DN mice compared to wild-type. Although we detected no difference in chronic apoptotic rates between transgenic and nontransgenic mice, analysis of acutely irradiated mice demonstrated that expression of the p38DN transgene significantly inhibited UVB-induced apoptosis of keratinocytes. These results counter the concerns that inhibition of p38 MAPK in a chronic situation could compromise the ability of the skin to eliminate potentially tumorigenic cells. Our data indicate that p38 MAPK is a good target for pharmacological intervention for UV-induced skin cancer in patients with sun damaged skin, and suggest that inhibition of p38 signaling reduces skin carcinogenesis by inhibiting COX-2 expression and proliferation of UVB-irradiated cells.
Noise reduction in magnetic resonance imaging (1988)

This paper describes a noise-reduction technique applicable to multiple-measurement systems. This method, known as measurement-dependent filtering (or MDF), can be used to advantage in a number of MRI applications. We present the general theory for one of these applications, material-canceled projection imaging. We discuss and show the results of MDF for material-canceled images as well as for heavily T2-weighted spin-echo images and computed T2 images. Significant improvements in SNR are demonstrated while spatial resolution is preserved.
Epidermal Growth Factor Receptor Gene Copy Number and Clinical Outcome of Metastatic Colorectal Cancer Treated With Panitumumab (2007)

In a larger and more homogeneous series than in previous studies, present exploratory data suggest that mCRC patients with tumors distinguishable by FISH analysis of EGFR as homogenously disomic or with low chromosome 7 polysomy have a reduced likelihood of response to panitumumab.
Design of Diamond Gradually - Dispersed Material by FEM (1999)

Diamond gradually-dispersed material is fabricated by the SHS (Self-propagating High-temperature Synthesis) method as a heat-resistant material. In a system of two layers composed of diamond dispersed and matrix layers, however, high residual stress must be generated in the interface. Therefore, gradually-dispersion of diamond in the matrix reaction is required to reduce the residual stress. In this study, the finite element method has been developed to evaluate macroscopic and microscopic stresses for the design of the diamond gradually-dispersed materials. The developed program for macroscopic analysis can treat an axi-symmetric specimens, allowing two dimensional models. The example model system composed Diamond/(TiB./Si) and TiB./Si layer. In this simulation, thermal residual stress, considering only elastic behavior as calculated. The residual stress is relaxed in a three layers system compared with the two layers system. In the three layers system, an effect of the number of laminas in the middle layer (division of the middle layer) on the residual stress between the matrix layer and the neighbor layer with least diamond concentration was evaluated The division of middle layer tend to reduce the residual stress effectively up to about ten laminas in the middle layer, but there was almost no farther effect with more than about ten laminas. We also have been developed an image mesh generation system to make the mesh model of microscopic structure, and carried out a microscopic analysis for diamond dispersed material by using the homogenization method. It is recognized that the developed system is able to apply to evaluate the stress of microscopic structure for particle dispersed materials.
Synthesis of S‐[3‐(4(5)‐imidazolyl)propyl],N‐[2(4‐{<sup>125</sup>I}‐iodophenyl)ethyl]isothiourea sulfate (<sup>125</sup>I‐iodophenpropit), a new probe for histamine H<sub>3</sub> receptor binding sites. (1992)

Abstract The synthesis of the first high specific activity { 125 I} labelled selective H 3 antagonist, Iodophenpropit‐ i.e., S‐[3‐(4(5)‐imidazolyl)propyl],N‐[2‐(4‐{ 125 I}‐iodophenyl)ethyl]isothiourea sulfate is reported. The radiolabelled compound was prepared by Cu(I)assisted nucleophilic non‐isotopic exchange from the corresponding bromo derivative (VUF 4598). The 125 I‐Iodophenpropit was purified using reverse phase HPLC and obtained in a chemical and radiochemical purity >98% and a specific activity of 1900 Ci/mmol.
Detecting stratigraphic features via cross‐plotting of seismic discontinuity attributes and their volume visualization (2009)

Over the last decade, our industry has witnessed steadily increasing computer power, core memory, peripheral storage, and advanced display technology, as well as development of commercial software, backed by dedicated research efforts. These developments have lead to a moderate acceptance of volume interpretation of 3D seismic data by the geoscience community. 3D volume rendering is one form of visualization that involves opacity control to view the features of interest ‘inside’ the 3D volume. A judicious choice of opacity applied to edge‐sensitive attribute sub‐volumes such as curvature or coherence co‐rendered with the seismic amplitude volume can both accelerate and lend confidence to the interpretation of complex structure and stratigraphy. In addition to co‐rendering, we evaluate an interpretation workflow that cross‐plots pairs of edge‐sensitive attributes. By crossploting coherence and an appropriate curvature attribute, we can define a polygon that highlights “clusters” that exhibit low coherence (indicating a discontinuity) and high curvature (indicating folding, flexing, fault drag, or differential compaction). Modern volume interpretation software allows us to link and display these interpreter‐defined clusters in the seismic volume for further examination. We illustrate the application of this new workflow through application to several 3D seismic surveys recently acquired in western Canada and demonstrate that multiattribute volume co‐rendering and clustering provides a powerful tool that leads to a better understanding of the spatial relationships between seismic attributes and the geologic objectives being pursued.
On-line을 활용한 영어 CBT 평가 시스템 개발에 관한 연구 (2003)

This paper suggests that the innovative synchronous and asynchronous evaluation system for the Web-Based English Instruction in terms of a set of two modes : On-line Performance- Based Testing mode and CAT(Computer-Adaptive Testing) mode. This system is suitable for the varied multimedia evaluation environment because it provides various media functions. It is estimated that this system has a high degree of efficiency, and low degree of periodical cost and time constraint. Applying the system`s various functions and interfacing, we can design and implement interactive electronic authentication for language testing. On-line Performance-Based Testing mode is designed to explore the applicability of computer technology to developing more valid measurement tools for the performance testing in cyberspace. This mode can be designed to include audio/video/chatting control to conduct group oral testing. The primary aim of this mode is to provide students with interactive testing environments to supplement authentic language use. CAT mode is designed to include an adaptive tool to construct on-line adaptive testing. In this mode, a student is free to take the test at any time within a specified time frame.
An integrated approach to attracting and retaining teachers in rural and remote parts of Australia (2015)

This paper presents an argument for an integrated approach to attracting and retaining rural and remote teachers. It describes existing government funded research and state government policies in this domain. It builds upon existing sociological models to propose a model of the factors influencing teacher decisions to teach in a rural location and to stay in a location. Based upon this model and the background literature the paper proposes that policy ought to be directed towards addressing both internal and external influences upon teacher behaviours in an integrated way.
Examining Interfacial Diffuse Phonon Scattering Through Transient Thermoreflectance Measurements of Thermal Boundary Conductance (2009)

Today’s electronic and optoelectronic devices are plagued by heat transfer issues. As device dimensions shrink and operating frequencies increase, ever-increasing amounts of thermal energy are being generated in smaller and smaller volumes. As devices shrink to length scales on the order of carrier mean free paths, thermal transport is no longer dictated by the thermal properties of the materials comprising the devices, but rather the transport of energy across the interfaces between adjacent materials in the devices. In this paper, current theories and experiments concerning phonon scattering processes driving thermal boundary conductance (hBD) are reviewed. Experimental studies of thermal boundary conductance conducted with the transient thermoreflectance technique challenging specific assumptions about phonon scattering during thermal boundary conductance are presented. To examine the effects of atomic mixing at the interface on hBD, a series of Cr/Si samples was fabricated subject to different deposition conditions. The varying degrees of atomic mixing were measured with Auger electron spectroscopy. Phonon scattering phenomena in the presence of interfacial mixing were observed with the trends in the Cr/Si hBD. The experimental results are reviewed and a virtual crystal diffuse mismatch model is presented to add insight into the effect of interatomic mixing at the interface. The assumption that phonons can only transmit energy across the interface by scattering with a phonon of the same frequency—i.e., elastic scattering, can lead to underpredictions of hBD by almost an order of magnitude. To examine the effects of inelastic scattering on hBD, a series of metal/dielectric interfaces with a wide range of vibrational similarity is studied at temperatures above and around materials’ Debye temperatures. Inelastic scattering is observed and new models are developed to predict hBD and its relative dependency on elastic and inelastic scattering events.
New mixed metal selenites and tellurites containing Pd<sup>2+</sup>ions in a square planar geometry (2011)

Four novel mixed metal selenites or tellurites containing PdO(4) squares, namely, BaPd(SeO(3))(2), Bi(2)Pd(SeO(3))(4), and Pb(2)Pd(QO(3))(2)Cl(2) (Q = Se, Te), have been prepared and structurally characterized by single crystal X-ray diffraction analyses. These compounds exhibit three different types of anionic structures. BaPd(SeO(3))(2) contains one-dimensional (1D) [Pd(SeO(3))(2)](2-) anionic chains composed of PdO(4) units linked by SeO(3)(2-) groups in a bidentate bridging fashion. Bi(2)Pd(SeO(3))(4) exhibits a complicated 3D architecture constructed by [Bi(SeO(3))](+) and [Pd(SeO(3))(2)](2-) layers that are alternating along the a-axis. The [Pd(SeO(3))(2)](2-) layers are composed of Pd(2+) ions bridged by SeO(3)(2-) anions in a bidentate fashion. Pb(2)Pd(QO(3))(2)Cl(2) (Q = Se, Te) features zero-dimensional (0D) [Pd(QO(3))Cl(2)](4-) (Q = Se, Te) anionic clusters, which are further bridged by Pb(2+) cations into a 3D network. The results of optical diffuse-reflectance spectrum measurements and band structure calculations based on DFT methods indicate that all the compounds are wide-band-gap semiconductors.
Developing adaptable user interfaces for component-based systems (2002)

Developing software components with user interfaces that can be adapted to diverse reuse situations is challenging. Examples of such adaptations include extending, composing and reconfiguring multiple-component user interfaces, and adapting component user interfaces to particular user preferences, roles and subtasks. We describe our recent work in facilitating such adaptation via the concept of "user interface aspects", which facilitate effective component user interface design and realisation using an extended component-based software architecture.
Epigenetically mismatched parental centromeres trigger genome elimination in hybrids (2021)

Wide crosses result in postzygotic elimination of one parental chromosome set, but the mechanisms that result in such differential fate are poorly understood. Here, we show that alterations of centromeric histone H3 (CENH3) lead to its selective removal from centromeres of mature <i>Arabidopsis</i> eggs and early zygotes, while wild-type CENH3 persists. In the hybrid zygotes and embryos, CENH3 and essential centromere proteins load preferentially on the CENH3-rich centromeres of the wild-type parent, while CENH3-depleted centromeres fail to reconstitute new CENH3-chromatin and the kinetochore and are frequently lost. Genome elimination is opposed by E3 ubiquitin ligase VIM1. We propose a model based on cooperative binding of CENH3 to chromatin to explain the differential CENH3 loading rates. Thus, parental CENH3 polymorphisms result in epigenetically distinct centromeres that instantiate a strong mating barrier and produce haploids.
<scp>A Two‐Factor Model for Stochastic Mortality with Parameter Uncertainty: Theory and Calibration</scp> (2006)

Abstract In this article, we consider the evolution of the post‐age‐60 mortality curve in the United Kingdom and its impact on the pricing of the risk associated with aggregate mortality improvements over time: so‐called longevity risk. We introduce a two‐factor stochastic model for the development of this curve through time. The first factor affects mortality‐rate dynamics at all ages in the same way, whereas the second factor affects mortality‐rate dynamics at higher ages much more than at lower ages. The article then examines the pricing of longevity bonds with different terms to maturity referenced to different cohorts. We find that longevity risk over relatively short time horizons is very low, but at horizons in excess of ten years it begins to pick up very rapidly. A key component of the article is the proposal and development of a method for calculating the market risk‐adjusted price of a longevity bond. The proposed adjustment includes not just an allowance for the underlying stochastic mortality, but also makes an allowance for parameter risk. We utilize the pricing information contained in the November 2004 European Investment Bank longevity bond to make inferences about the likely market prices of the risks in the model. Based on these, we investigate how future issues might be priced to ensure an absence of arbitrage between bonds with different characteristics.
Amelioration of renal ischaemia–reperfusion injury by liposomal delivery of curcumin to renal tubular epithelial and antigen‐presenting cells (2011)

Liposomal delivery of curcumin promoted effective, targeted delivery of this non-toxic compound that provided cytoprotection via anti-inflammatory and multiple antioxidant mechanisms following renal IR injury.