gebhart/patrepeval huggingface dataset:
Identity management using blockchain for cognitive cellular networks (2017)

Cloud-centric cognitive cellular networks utilize dynamic spectrum access and opportunistic network access technologies as a means to mitigate spectrum crunch and network demand. However, furnishing a carrier with personally identifiable information for user setup increases the risk of profiling in cognitive cellular networks, wherein users seek secondary access at various times with multiple carriers. Moreover, network access provisioning - assertion, authentication, authorization, and accounting - implemented in conventional cellular networks is inadequate in the cognitive space, as it is neither spontaneous nor scalable. In this paper, we propose a privacy-enhancing user identity management system using blockchain technology which places due importance on both anonymity and attribution, and supports end-to-end management from user assertion to usage billing. The setup enables network access using pseudonymous identities, hindering the reconstruction of a subscriber's identity. Our test results indicate that this approach diminishes access provisioning duration by up to 4x, decreases network signaling traffic by almost 40%, and enables near real-time user billing that may lead to approximately 3x reduction in payments settlement time.
A Synthesis of 9-Methoxy-1-Methyl-1<i>H</i>,6<i>H</i>-Pyrazolo[4,3-<i>c</i>]Carbazole (1996)

International audience
Tyrosine 115 participates both in chemical and physical steps of the catalytic mechanism of a glutathione S-transferase (1993)

The participation of the hydroxyl group of tyrosine 115 in the catalytic mechanism of isoenzyme 3-3 of rat glutathione (GSH) S-transferase is implicated by x-ray crystallographic analysis of a product complex and confirmed by comparison of the catalytic properties of the native enzyme and the Y115F mutant. Tyrosine 115 is located in domain II of the protein (the xenobiotic substrate binding domain) and is the first residue in this domain to be shown to play a direct role in catalysis. The 1.8-A structure of isoenzyme 3-3 in complex with (9S,10S)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene, one of the diastereomeric products of the reaction of GSH with phenanthrene 9,10-oxide, indicates that the hydroxyl group of Tyr115 is within hydrogen-bonding distance of the 10-hydroxyl group of the bound product and, by implication, is proximal to the oxirane oxygen of the substrate in the Michaelis complex. Site-specific replacement of Tyr115 with phenylalanine has profoundly different effects on catalysis depending on the type of reaction and whether the rate-limiting step in catalysis is a chemical step or a physical step. Stopped flow measurements of the rate constants for product release and viscosity effects on the steady-state kinetics establish that the rate-limiting step in catalysis with phenanthrene 9,10-oxide (kcat = 0.4 s-1) is probably a chemical one, whereas the physical step of product dissociation (koff) is rate-limiting in the reaction of 1-chloro-2,4-dinitrobenzene (kcat = 20 s-1). The Y115F mutant is severely impaired in catalyzing the addition of GSH to phenanthrene 9,10-oxide (kcat = 0.0044 s-1), evidence that the -OH of Tyr115 provides electrophilic assistance in the epoxide ring opening. In contrast, the Y115F mutant is a better catalyst toward 1-chloro-2,4-dinitrobenzene (kcat = 72 s-1) than is the native enzyme. The enhanced rates of product release in the mutant are ascribed to the loss of hydrogen bonds between the -OH of Tyr115 and the side chain -OH and main chain NH of serine 209, interactions that block the channel to the active site or inhibit the segmental motion of the protein.
Improvement of tylosin fermentation by mutation and medium optimization (1999)

A tylosin-hyperproducing mutant of Streptomyces fradiae MNU20 was isolated from 3500 strains obtained from either MNNG- or u.v.-treated S. fradiae NRRL2702. With the optimal medium, S. fradiae MNU20 was able to produce 159 mg tylosin g biomass(-1), indicating the tylosin productivity in S. fradiae NRLL2702 was increased 14-fold by mutation and medium optimization. When the effect of valine, succinate and natural zeolite on tylosin production was investigated sing the optimal medium, these substances essentially enhanced tylosin production up to 349 mg g biomass(-1); their time addition during the culture period appeared to be critical for the increase.
Discussing aspects of AOP (2001)

article Share on Discussing aspects of AOP Authors: Tzilla Elrad Illinois Institute of Technology, Chicago, IL Illinois Institute of Technology, Chicago, ILView Profile , Mehmet Aksit University of Twente, The Netherlands University of Twente, The NetherlandsView Profile , Gregor Kiczales University of British Columbia, British Columbia, Canada University of British Columbia, British Columbia, CanadaView Profile , Karl Lieberherr Northeastern University, Boston, MA Northeastern University, Boston, MAView Profile , Harold Ossher IBM T.J. Watson Research Center, Yorktown Heights, NY IBM T.J. Watson Research Center, Yorktown Heights, NYView Profile Authors Info & Claims Communications of the ACMVolume 44Issue 10Oct. 2001pp 33–38https://doi.org/10.1145/383845.383854Published:01 October 2001Publication History 106citation9,148DownloadsMetricsTotal Citations106Total Downloads9,148Last 12 Months23Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Preliminary measurements with an automated compact differential absorption lidar for the profiling of water vapor (2004)

The design and preliminary tests of an automated differential absorption lidar (DIAL) that profiles water vapor in the lower troposphere are presented. The instrument, named CODI (for compact DIAL), has been developed to be eye safe, low cost, weatherproof, and portable. The lidar design and its unattended operation are described. Nighttime intercomparisons with in situ sensors and a radiosonde are shown. Desired improvements to the lidar, including a more powerful laser, are also discussed.
Identification of a 17000 Molecular Weight Antigenic Polypeptide in Transmissible Gastroenteritis Virus-infected Cells (1986)

Pulse labelling of cells with [35S]methionine at different times after infection followed by SDS-PAGE was used to resolve and to identify polypeptides designated as specific to transmissible gastroenteritis virus (TGEV)-infected swine testicular (ST) cell cultures. The major TGEV structural proteins, with apparent molecular weights of 200,000 (200K), 47K and 30K were detected in radiolabelled cell extracts by 6 h postinfection. Additionally, a 17K major polypeptide was present in infected cells but not in mock-infected control cultures. Labelling with [3H]glucosamine revealed only the 200K and 30K proteins to be glycosylated. TGEV-primed porcine lymphocytes, secondarily stimulated in vitro with sucrose gradient-purified virus, produced antibody only to the two glycoproteins (gp) indicating that the 17K polypeptide is not a surface feature of the virion. Two pigs were infected oronasally with the virulent Miller strain of TGEV and their sera were analysed by immunoprecipitation. At 25 days postinfection convalescent sera responded strongly to gp30 and gp200 and there was a weak initial response to the 17K polypeptide. Serum immunoglobulins at 60 days postinfection reacted strongly to the 17K protein while the antibody response to gp30 was significantly reduced and that to gp200 was slightly reduced.
Teamwork with the Next Generation (2002)

This article discusses about Nightline, a robotics competition in which teams of students and engineers built robots that competed against each other in a sports-style event known as FIRST (For Inspiration and Recognition of Science and Technology). Creativity, communication, project management, partnerships, and a fundamental re-energizing of the engineering spirit are among the benefits that engineers and their supervisors describe as side effects of their involvement. While access to a future employee pool may be the reason that many organizations decide to get involved with FIRST, those side benefits are the reason most of them continue to participate. In many respects, FIRST has been turning out to be a fountain of youth. When hiring engineers, defense contractors have the added hurdle of getting their employees security clearance.
Managing hot flushes in men receiving androgen deprivation therapy for prostate cancer (2014)

Abstract In this series, the authors present cases of men being treated with androgen deprivation therapy, and highlight management strategies to prevent and treat associated toxicities. In this fourth article, the authors consider the management of hot flushes. Copyright © 2014 John Wiley & Sons
Structure-Activity Relationship of Compounds which are Anti-Schistosomiasis Active (1998)

The molecular orbital method AM1 was employed to calculate a set of molecular descriptors for twenty synthetic neolignan derivatives with anti-schistosomiasis activity. The pattern recognition method (principal component analysis PCA and cluster analysis CA and discriminant analysis methods) have been employed to obtain the relationship between the molecular descriptors and biological activity. The set of molecules was classified into two groups according to their degree of biological activity. These results allow us to rationally project new compounds, potential candidates for synthesis and biological evaluation.
Prediction of dielectric breakdown in shock−loaded ferroelectric ceramics (1975)

Recent investigations of dielectric breakdown of a poled ferroelectric ceramic suggest that the same mechanisms are acitve in shock−loading and ambient−condition experiments. Further work described here supported this view for PZT 65/35. Breakdown in shock−loaded specimens can be predicted from ambient and quasistatic−loading data using the concept of a critical particle energy. The effects of the ferroelectric−to−paraelectric transformation and other factors are discussed for shock−loaded PZT materials.
A Common Evolutionary Origin for Tailed-Bacteriophage Functional Modules and Bacterial Machineries (2011)

Bacteriophages belonging to the order Caudovirales possess a tail acting as a molecular nanomachine used during infection to recognize the host cell wall, attach to it, pierce it, and ensure the high-efficiency delivery of the genomic DNA to the host cytoplasm. In this review, we provide a comprehensive analysis of the various proteins constituting tailed bacteriophages from a structural viewpoint. To this end, we had in mind to pinpoint the resemblances within and between functional modules such as capsid/tail connectors, the tails themselves, or the tail distal host recognition devices, termed baseplates. This comparison has been extended to bacterial machineries embedded in the cell wall, for which shared molecular homology with phages has been recently revealed. This is the case for the type VI secretion system (T6SS), an inverted phage tail at the bacterial surface, or bacteriocins. Gathering all these data, we propose that a unique ancestral protein fold may have given rise to a large number of bacteriophage modules as well as to some related bacterial machinery components.
The Influence of Base Oil Properties on the Friction Behaviour of Lithium Greases in Rolling/Sliding Concentrated Contacts (2017)

This study investigates the influence of base oil type and viscosity on the frictional behaviour of lithium-thickened bearing greases. A series of model lithium greases were manufactured by systematically varying viscosity and type of base oil, so that the influence of a single base oil property could be studied in isolation. In addition, selected greases were blended with oleic acid, with the purpose of evaluating its effectiveness in further reducing grease friction. Friction coefficient and film thickness were measured in laboratory ball-on-disc tribometers over a range of speeds and temperatures. For a specific oil type, the influence of base oil viscosity on friction was found to be closely related to its effect on film thickness: greases formulated with PAO oils covering a wide range of viscosities gave very similar friction at the same nominal film thickness. For a given base oil viscosity, base oil type was found to have a strong influence on grease friction under all test conditions. PAO-based greases generally produced lower friction than mineral- and ester-based greases. Addition of oleic acid to the test greases did not significantly affect friction within the range of test conditions employed in this study. The results provide new insight into the frictional behaviour of greases, which may be used to help inform new low-friction grease formulations for rolling bearing applications.
Antibodies against the NG2 Proteoglycan Promote the Regeneration of Sensory Axons within the Dorsal Columns of the Spinal Cord (2006)

The NG2 chondroitin sulfate proteoglycan inhibits axon growth in vitro. Levels of NG2 increase rapidly in the glial scars that form at sites of CNS injury, suggesting that NG2 may inhibit axon regeneration. To determine the functions of NG2, we infused mixtures of neutralizing or non-neutralizing anti-NG2 monoclonal antibodies into the dorsally transected adult rat spinal cord and analyzed the regeneration of ascending mechanosensory axons anatomically. At 1 week after injury, ascending sensory axons in control animals terminated caudal to the lesion within an area containing dense deposits of NG2 immunoreactivity. In animals treated with the neutralizing anti-NG2 antibodies, labeled axons penetrated the caudal border of the lesion and grew into and beyond the lesion center. The low intrinsic growth capacity of adult neurons may also limit the ability of damaged axons to regenerate. To enhance growth, we combined antibody treatment with a peripheral nerve conditioning lesion. After a conditioning lesion and treatment with control, non-neutralizing antibodies, many sensory axons grew into the lesion core. These axons did not grow past the rostral border of the lesion; rather, they grew along the dorsal surface of the spinal cord and within any remaining pieces of the dorsal roots. In contrast, combining a peripheral nerve conditioning lesion with neutralizing anti-NG2 antibodies resulted in sensory axon regeneration past the glial scar and into the white matter rostral to the injury site. The combinatorial approach used here that neutralizes extrinsic inhibition and increases intrinsic growth results in anatomically correct axon regeneration, a prerequisite for functional recovery.
Prime von Neumann regular rings and primitive group algebras (1974)

Kaplansky posed the following question: Are prime von Neumann regular rings primitive? We show that with a certain countability condition the answer is affirmative. This is used to simplify and clarify earlier work on the existence of primitive group algebras.
Focused Crawling by Learning HMM from User's Topic-specific Browsing (2004)

A focused crawler is designed to traverse the Web to gather documents on a specific topic. It is not an easy task to predict which links lead to good pages. In this paper, we present a new approach for prediction of the important links to relevant pages based on a learned user model. In particular, we first collect pages that a user visits during a learning session, where the user browses the Web and specifically marks which pages she is interested in. We then examine the semantic content of these pages to construct a concept graph, which is used to learn the dominant content and link structure leading to target pages using a Hidden Markov Model (HMM). Experiments show that with learned HMM from a user's browsing, the crawling performs better than Best-First strategy.
A Method of Estimating Formation Pressures from Gulf Coast Well Logs: ABSTRACT (1966)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Complement activation by IgM: evidence for the importance of the third constant domain of the μ heavy chain (1987)

We have isolated and analyzed the DNA encoding the mu heavy chain constant region of a mutant IgM which is defective in initiating complement-dependent cytolysis. By assaying the expression of mu genes which were constructed in vivo from mutant and normal gene segments, we have mapped the mutation into a 555-base pair segment. In this segment there is one nucleotide change, such that the mutant mu gene encodes serine rather than the normal proline at amino acid position 436 in the third constant domain. We have used site-directed mutagenesis to revert this mutation to the normal sequence and shown that this substitution results in the production of IgM with the normal phenotype.
Invited Review: The circle of life: cell cycle regulation in airway smooth muscle (2001)

Severe asthma is characterized by increased airway smooth muscle (ASM) mass, due predominantly to ASM hyperplasia. Diverse stimuli, which include growth factors, plasma- or inflammatory cell-derived mediators, contractile agonists, cytokines, and extracellular matrix proteins, induce ASM proliferation. Mitogens act via receptor tyrosine kinase, G protein-coupled receptors, or cytokine receptors, to activate p21ras and stimulate two parallel signaling pathways in ASM cells, namely, the extracellular signal-regulated kinase (ERK) or the phosphatidylinositol 3-kinase (PI3K) pathways. ERK and PI3K regulate cell cycle protein expression and thus modulate cell cycle traversal. ERK activation and downstream effectors of PI3K, such as Rac1 and Cdc42, stimulate expression of cyclin D1, a key regulator of G(1) progression in the mammalian cell cycle. In addition, PI3K activates 70-kDa ribosomal S6 kinase, an enzyme that also regulates the translation of many cell cycle proteins, including the elongation factor E2F. The present review examines the mitogens and critical signal transduction pathways that stimulate ASM cell proliferation. Further study in this area may reveal new therapeutic targets to abrogate ASM hyperplasia in diseases such as asthma and chronic obstructive pulmonary disease.
Analysis of malignancy-associated DNA changes in interphase nuclei of buccal epithelium in persons with breast diseases. (2004)

The method proposed may be recommended as an additional one for improvement of the diagnosis of mammary pathologies.
Introduction: Letters From Abroad (2017)

An introduction to a series of essays by educators who reflect on their choices to live and work in other parts of the world. They offer a provocative range of personal and professional explanations for seeking out the strange and unknown.
Effect of culture temperature on fatty acid composition of<i>Chlorella sorokiniana</i> (1970)

Abstract Chlorella sorokiniana was grown for extraction of fatty acids at seven temperatures ranging from 14 C to 38 C. The predominant fatty acids in C. sorokiniana grown at 38 C were saturated (46% of total); at 22 C, triunsaturated (40% of total); and at 14 C diunsaturated (47% of total). Increasing temperature resulted in an increase in the degree of unsaturation from 14 C to 22 C, but further increases in temperature always resulted in a decrease in unsaturation. At any point in the temperature range used, an increased temperature always resulted in fatty acids with a lower average chain length. Total fatty acid production was greatest at the extremes of temperature and lowest at 26 C. The chain length and degree of saturation of fatty acids increased at temperatures lower than 22 C. Therefore, the fatty acids of C. sorokiniana do not have an increasingly lower melting point when the culture temperature is reduced at temperatures 22 C or below.
Sound intensity and particle velocity based three-dimensional panning methods by five loudspeakers (2013)

In this paper, we present two new 3D panning methods. One method guarantees that time-average sound intensity and sound pressure of a virtual sound source at the receiving point are the same as time-averaged sound intensity and sound pressure of five loudspeakers at the receiving point. Another method maintains the direction of particle velocity and sound pressure. These methods can realize using five loudspeakers to replace a virtual sound source. These approaches relies on the assumption that the virtual sound source and five loudspeakers are on the same sphere and the virtual sound source needs to be in the area of a spherical pentagon that consists of the five loudspeakers. In the situation of five loudspeakers replacing a virtual source, these new methods do not need to undertake loudspeakers grouping. Compared with traditional 3D panning methods, these new methods are more convenient.
Copper(II)-Mediated Autoxidation of <i>tert</i>-Butylresorcinols (2003)

Although copper(II)-mediated oxidation of phenols results in oxidative coupling rather than in oxygenation, it was recently reported that naturally occurring 5-alkylresorcinols undergo oxygenation in the presence of copper(II). To explore the generality of this reaction, the copper(II)-mediated autoxidation of 4-tert-butylresorcinol and 4,6-di-tert-butylresorcinol was investigated and was found to result in direct oxygenation at open activated positions and, at the tert-butyl-substituted positions, in oxygenation with competing loss of (as isobutylene) and 1,2-rearrangement of the tert-butyl group. 5-tert-Butyl-2-hydroxy-1,4-benzoquinone is the major product from both starting materials, and the final product mixture reflects, in part, coupling of metastable initially formed electrophilic and nucleophilic side products. Mechanisms that are consistent with the observed products and control reactions are proposed. The key step appears to be equilibration of a copper(II)-resorcinolate with a charge-transfer radical form that reacts regioselectively with O(2) as prescribed by resonance.