gebhart/patrepeval huggingface dataset:
Survivability and Resiliency of Spacecraft and Space-Based Networks: A Framework for Characterization and Analysis (2008)

Considerations of survivability and resiliency have always been of importance in the design and analysis of military systems. Over the p ast two decades, the importance of survivability and resiliency has expanded beyond mi litary systems to include public networks and infrastructure systems. The analysis a nd assessment of networked systems with respect to survivability has become particular ly acute in recent years, as attested to by a growing technical literature on the subject. In this paper, we bring these considerations of su rvivability and resiliency to bear on spacecraft and space-based networks. We develop a framework for comparing the survivability and resiliency of different space arc hitectures, namely that of a monolithic design and a distributed (or networked) space syste m architecture. There are multiple metrics along which different space architectures c an be benchmarked and compared. We argue that if survivability and resiliency are not accounted for, then the evaluation process is likely to be biased in favor of monolithic spacecra ft. We show that if in a given context survivability and resiliency are an important requi rement for a particular customer, then a distributed architecture is more likely to satisfy this requirement than a monolithic spacecraft design. We discuss in the context of our framework differe nt classes of threats, as well as the high-frequency and low-frequency system response to (or coping strategies with) these shocks or damaging events. We illustrate the import ance of this characterization for a formal definition of survivability and resiliency a nd a proper quantitative analysis of the subject. Finally, we propose in future work to inte grate our framework with a design tool that allows the exploration of the design trade-spa ce of distributed space architecture and show how survivability can be “optimized” or traded against other system attributes.
How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire (2016)

How T-cell receptors (TCRs) can be intrinsically biased toward MHC proteins while simultaneously display the structural adaptability required to engage diverse ligands remains a controversial puzzle. We addressed this by examining αβ TCR sequences and structures for evidence of physicochemical compatibility with MHC proteins. We found that human TCRs are enriched in the capacity to engage a polymorphic, positively charged "hot-spot" region that is almost exclusive to the α1-helix of the common human class I MHC protein, HLA-A*0201 (HLA-A2). TCR binding necessitates hot-spot burial, yielding high energetic penalties that must be offset via complementary electrostatic interactions. Enrichment of negative charges in TCR binding loops, particularly the germ-line loops encoded by the TCR Vα and Vβ genes, provides this capacity and is correlated with restricted positioning of TCRs over HLA-A2. Notably, this enrichment is absent from antibody genes. The data suggest a built-in TCR compatibility with HLA-A2 that biases receptors toward, but does not compel, particular binding modes. Our findings provide an instructional example for how structurally pliant MHC biases can be encoded within TCRs.
Atopic Eczema, Langerhans Cells and Allergy (1991)

While the pathomechanisms of respiratory atopy are rather well established, the role of IgE-mediated hypersensitivity in the elicitation and maintenance of eczematous skin lesions in atopic eczema is still controversial. Few diseases are characterized by an equally elevated production of IgE antibodies as atopic eczema. Many authors, however, regard this only as epiphenomenon. On the other hand, there is clearcut clinical evidence for exogenous elicitation of atopic eczema by contact with aero or food allergens. A variety of hypotheses may help to explain the participation of IgE antibodies in the induction of eczema: vasoactive mediators secreted by skin mast cells or basophils after allergen contact may produce itch, contact urticaria or a 'late-phase-reaction' with consequent eczematous skin changes further maintained by scratch responses. Recent investigations stress a possible role of Langerhans cells in the epidermis with a low affinity receptor for IgE with possible function for antigen presentation, mediator release or regulatory interactions. Certain cytokines such as interleukin-4 or gamma-interferon are able to enhance the expression of the IgE-receptor on the surface of Langerhans cells. IL-4 and gamma-interferon act synergistically in this respect on Langerhans cells, contrary to B cells. Furthermore lymphocytes may act directly via certain cytokines (e.g. histamine releasing factor, chemotactic factors etc.) on mast cells or eosinophil granulocytes in a proinflammatory sense. Eosinophils seem also to be involved in the inflammatory response in atopic eczema by releasing products such as major basic protein (MBP) or eosinophil cationic protein (ECP) which has been found to be elevated in severe atopic eczema.(ABSTRACT TRUNCATED AT 250 WORDS)
Mevalonate-Dependent Inhibition of Transendothelial Migration and Chemotaxis of Human Peripheral Blood Neutrophils by Pravastatin (1997)

Pravastatin, a hydrophilic inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, has been reported to beneficially affect atherogenesis, plaque stability, and transient myocardial ischemia in significant coronary artery disease by influencing lipid metabolism and by intracellular signaling via mevalonate pathway products other than cholesterol. Leukocytes are implicated to play a pathophysiological role in these events. We were interested in finding out whether pravastatin could affect transendothelial migration (TEM), chemotaxis, and respiratory burst activity of the neutrophil ex vivo. In addition, effects on monocyte and T-lymphocyte chemotaxis were tested. For TEM assays, monolayers of human umbilical vein endothelial cells (HUVECs) were grown to confluence on polycarbonate filters bearing 5-microns pores in Transwell (Costar) culture plate inserts. Chemotaxis experiments were performed using modified Boyden chambers with cellulose nitrate micropore filters. Respiratory burst activity was measured fluorometrically. Treatment of neutrophils and monocytes with pravastatin at 2 to 200 mumol/L and 10 to 1000 mumol/L, respectively, significantly decreased chemotaxis triggered by fMet-Leu-Phe. This effect was abolished in the presence of mevalonic acid (500 mumol/L); no effect of pravastatin was seen on T-lymphocyte chemotaxis triggered by interleukin-8. Preincubation of neutrophils with pravastatin (200 mumol/L) also resulted in a significant reduction in the number of neutrophils that transmigrated a tumor necrosis factor-stimulated or lipopolysaccharide-stimulated HUVEC monolayer. At none of the concentrations tested (2 pmol/L to 200 mumol/L) did pravastatin affect neutrophil respiratory burst activity. We conclude that pravastatin may alter monocyte chemotaxis and neutrophil-endothelial interactions in migratory responses at concentrations obtained in vivo with cholesterol-lowering doses.
Spatial distribution of the electrical conductivity in highly filled polymers: Experiment, modeling, and application to bipolar plates (2013)

A large variety of composites for electrical applications are developed worldwide on a daily basis. Most of these materials are made from carbonaceous fillers dispersed in polymers. The optimization of the formulations is complex and depends on parameters that are difficult to identify ab initio. The results might also be very sensitive to the processing conditions. There is therefore a need for a fast and accurate method to measure the electrical properties of samples with unfamiliar geometric features and without altering their shape. A four point probes method is incremented that fulfills all the above mentioned requirements. An analytical model is proposed that extends Uhlirs theory and permits to quickly determine the resistivity distribution. Experimental and theoretical approaches were performed to validate the method. An example is proposed with the measurement of samples initially designed for fuel cell-bipolar plates-application.
24H Intragastric Acidity and Plasma Gastrin Concentration in Female and Male Subjects (1990)

Conference Abstract| January 01 1990 24H Intragastric Acidity and Plasma Gastrin Concentration in Female and Male Subjects EJ Prewett; EJ Prewett 1Academic Department of Medicine, Royal Free Hospital School of Medicine, London NW3 Search for other works by this author on: This Site PubMed Google Scholar JTL Smith; JTL Smith 1Academic Department of Medicine, Royal Free Hospital School of Medicine, London NW3 Search for other works by this author on: This Site PubMed Google Scholar CU Nwokolo; CU Nwokolo 1Academic Department of Medicine, Royal Free Hospital School of Medicine, London NW3 Search for other works by this author on: This Site PubMed Google Scholar AM Sawyerr; AM Sawyerr 1Academic Department of Medicine, Royal Free Hospital School of Medicine, London NW3 Search for other works by this author on: This Site PubMed Google Scholar RE Pounder RE Pounder 1Academic Department of Medicine, Royal Free Hospital School of Medicine, London NW3 Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8736 Print ISSN: 0143-5221 © 1990 The Biochemical Society and the Medical Research Society1990 Clin Sci (Lond) (1990) 78 (s22): 37P. https://doi.org/10.1042/cs078037Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation EJ Prewett, JTL Smith, CU Nwokolo, AM Sawyerr, RE Pounder; 24H Intragastric Acidity and Plasma Gastrin Concentration in Female and Male Subjects. Clin Sci (Lond) 1 January 1990; 78 (s22): 37P. doi: https://doi.org/10.1042/cs078037Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1990 The Biochemical Society and the Medical Research Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Application of the Syva EMIT and Abbott TDx Amphetamine Immunoassays to the Detection of 3,4-Methylenedioxymethamphetamine (MDMA) and 3,4-Methylenedioxyethamphetamine (MDEA) in Urine (1990)

MDMA and MDEA are hallucinogenic analogs of amphetamine. The need for laboratory monitoring of these substances has developed as a result of their increased recreational use. Since the Abbott TDx and Syva EMIT-d.a.u. immunoassays are commonly used tests for urine monitoring of drugs-of-abuse, the amphetamine assay of each manufacturer was assessed to determine the degree of cross-reactivity with MDMA and MDEA. Cross-reactivity was evaluated using a series of MDMA- and MDEA-spiked urine samples. Testing was performed over a two-day period with 3 runs/day and each sample run in duplicate. The Syva EMIT d.a.u. amphetamine assay was positive only at the highest concentration standard (10.0 micrograms/mL) for both MDMA and MDEA. Consequently, no further testing was performed with this assay. Calibration curves were generated for the TDx runs and percent cross-reactivity determinations were made. Precision for the TDx data was evaluated based on within-day and between-day coefficients of variation (CV). CVs for MDMA runs were below 6% for within-day and below 5% for between-day runs. Values of CV for MDEA were below 16% for both within-day and between runs; CVs were less than 2.5% for positive values. Cross-reactivity for MDMA ranged from 18% (10.00 micrograms/mL) to 118% (0.15 microgram/mL). Cross-reactivity for the MDEA standards ranged from 12% (10.00 micrograms/mL) to 47% (0.15 micrograms/mL). The presence of MDMA and/or MDEA in samples resulting in a negative EMIT-d.a.u. test and a positive TDx test was confirmed by GC/MS analysis.(ABSTRACT TRUNCATED AT 250 WORDS)
At-Sea Development of a Multiplexed Fibre Optic Hydrophone Array (1988)

The reflectometric pulsed interferometer is particularly attractive as the basis of a multiplexed hydrophone array, and the main components of such a system have been described elsewhere (1-5). In this paper, a six hydrophone multiplexed array is described and its performance at sea is discussed.
The Need of a Hybrid Storage Approach for IoT in PaaS Cloud Federation (2014)

Monitoring activities over many different types of sensors are very challenging to support advanced services for Internet of Things (IoT) and its future. However, one of the major issues is the explosion of the amount of heterogeneous information that has to be stored and processed, thus causing the well known Big Data problem. Some Cloud strategies have been investigated to offer IoT-oriented services, but they do not specifically address solutions for Big Data management. In this paper, we present a two-layer architecture based on a hybrid storage system able to support a Platform as a Service (PaaS) federated Cloud scenario. The proposed architecture combines the benefits of both storage approaches. In particular, it allows us on one hand to extend SQL-like legacy systems, and on the other hand to manage Big Data through an XML-like, non-SQL distributed storage system according to a Cloud federation approach.
BRITE: Universal Topology Generation from a User''s Perspective (2001)

Effective engineering of the Internet is predicated upon a detailed understanding of issues such as the large-scale structure of its underlying physical topology, the manner in which it evolves over time, and the way in which its constituent components contribute to its overall function. Unfortunately, developing a deep understanding of these issues has proven to be a challenging task, since it in turn involves solving difficult problems such as mapping the actual topology, characterizing it, and developing models that capture its emergent behavior. Consequently, even though there are a number of topology models, it is an open question as to how representative the topologies they generate are of the actual Internet. Our goal is to produce a topology generation framework which improves the state of the art and is based on design principles which include representativeness, inclusiveness, and interoperability. Representativeness leads to synthetic topologies that accurately reflect many aspects of the actual Internet topology (e.g. hierarchical structure, degree distribution, etc.). Inclusiveness combines the strengths of as many generation models as possible in a single generation tool. Interoperability provides interfaces to widely-used simulation and visualization applications such as ns and SSF. We call such a tool a universal topology generator. In this paper we discuss the design, implementation and usage of the BRITE universal topology generation tool that we have built. We also describe the BRITE Analysis Engine, BRIANA, which is an independent piece of software designed and built upon BRITE design goals of flexibility and extensibility. The purpose of BRIANA is to act as a repository of analysis routines along with a user–friendly interface that allows its use on different topology formats.
Cytokine and autoantibody patterns in acute liver failure (2009)

The mechanisms of idiosyncratic drug-induced liver injury (IDILI) are still a matter of dispute. Some of the characteristics of reactions that have been classed as metabolic idiosyncrasy could also be those of an immune-mediated reaction with an autoimmune component. Many auto-immune reactions appear to be mediated by T(H)17 cells, which are in part characterized by the production of interleukin (IL)-17. To test the involvement of T(H)17 cells in IDILI, we quantified a number of cytokines, chemokines, and autoantibodies in the serum of 39 patients with acute liver failure (ALF) due to IDILI and compared the values with those from 21 patients with acetaminophen-induced ALF and 10 patients with viral hepatitis-induced ALF. The IL-17 levels were elevated in 60% of patients with IDILI, but also in a similar number of patients with acetaminophen-induced ALF and occasionally in patients with viral hepatitis. Levels of other cytokines, such as IL-21, that are also produced by T(H)17 cells were higher in patients with IDILI, but again, there was overlap with acetaminophen DILI. Autoantibodies were more frequent in patients in the IDILI group but were absent in most patients. These data provide a picture of the cytokine/chemokine profile in patients with various types of ALF. The pattern varies from patient to patient and not specifically by etiology. This suggests that different underlying disease mechanisms may be at play in different individuals, even among those demonstrating injury from the same drug. Since cytokines may originate from more than one type of cell, interpretation of results of cytokine assays remains difficult in complex disease settings.
Propagation in shielded microslot on ferrite substrate (1971)

Using the method of moments, analysis is implemented for a completely shielded microslot on a ferrite substrate, i.e. a slotline with a parallel ground plane. Accuracy in the propagation constant as a function of slot line geometry, ferrite parameters and magnetising field of within 1% is obtained using matrices as small as five-by-five.
A method for converting between cylindrical and spherical harmonic representations of sound fields (2014)

Spherical microphone and circular microphone arrays are useful for sampling sound fields that may be resynthesized with loudspeaker arrays. Spherical microphone arrays are desirable because of their ability to capture three-dimensional sound fields, however it is often more practical to construct loudspeaker arrays in the form of a closed circle located in the horizontal plane. This leads to a spatial undersampling as such a circular sampling can only yield a perfect representation of a height-invariant sound field. This paper investigates the consequences of such spatial undersampling by converting between cylindrical and spherical harmonic decompositions of solutions to the wave equation. We show analytically and via numerical simulations that 1) the result of the spatial undersampling is a purely horizontally propagating sound field, and 2) the ratio of travelling and standing components in the undersampled sound field varies depending on the incidence colatitude. The conversion is also used in a beamforming scenario and shows that the beamformer response becomes increasingly omnidirectional as the source moves away from the horizontal plane.
Statistical Survey of Victorian Health Libraries 2002-2003 (2004)

The annual statistical survey is for all independent Victorian health sciences libraries, including those in clinical and research organisations, and in organisations providing consumer health information. The survey excludes two major players in the field, namely Clinicians Health Channel (but see note below) and the university libraries. The key findings of the survey of Victorian health libraries during the period 2002-2003 are discussed.
A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in <i>Caenorhabditis elegans</i> (1996)

Sex myoblast migration in the Caenorhabditis elegans hermaphrodite represents a simple, genetically amenable model system for studying how cell migration is regulated during development. Two separable components of sex myoblast guidance have been described: a gonad-independent mechanism sufficient for the initial anterior migration to the mid-body region, and a gonad-dependent mechanism required for precise final positioning (J. H. Thomas, M. J. Stern and H. R. Horvitz (1990) Cell 62, 1041-1052). Here, we demonstrate a role for a Ras-mediated signal transduction pathway in controlling sex myoblast migration. Loss-of-function mutations in let-60 ras, ksr-1, lin-45 raf, let-537/mek-2 or sur-1/mpk-1 cause defects in sex myoblast final positions that resemble those seen in gonad-ablated animals, while constitutively active let-60 ras(G13E) trans-genes allow fairly precise positioning to occur in the absence of the gonad. A mosaic analysis demonstrated that let-60 ras is required within the sex myoblasts to control proper positioning. Our results suggest that gonadal signals normally stimulate let-60 ras activity in the sex myoblasts, thereby making them competent to sense or respond to positional cues that determine the precise endpoint of migration. let-60 ras may have additional roles in sex myoblast guidance as well. Finally, we have also investigated genetic interactions between let-60 ras and other genes important for sex myoblast migration, including egl-15, which encodes a fibroblast growth factor receptor tyrosine kinase (D. L. DeVore, H. R. Horvitz and M. J. Stern (1995) Cell 83, 611-623). Since mutations reducing Ras pathway activity cause a different phenotype than those reducing egl-15 activity and since constitutive Ras activity only partially suppresses the migration defects of egl-15 mutants, we argue that let-60 ras and egl-15 do not act together in a single linear pathway.
5‐HT <sub>6</sub> receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia (2012)

Cognitive deficits in schizophrenia severely compromise quality of life and are poorly controlled by current antipsychotics. While 5-HT(6) receptor blockade holds special promise, molecular substrates underlying their control of cognition remain unclear. Using a proteomic strategy, we show that 5-HT(6) receptors physically interact with several proteins of the mammalian target of rapamycin (mTOR) pathway, including mTOR. Further, 5-HT(6) receptor activation increased mTOR signalling in rodent prefrontal cortex (PFC). Linking this signalling event to cognitive impairment, the mTOR inhibitor rapamycin prevented deficits in social cognition and novel object discrimination induced by 5-HT(6) agonists. In two developmental models of schizophrenia, specifically neonatal phencyclidine treatment and post-weaning isolation rearing, the activity of mTOR was enhanced in the PFC, and rapamycin, like 5-HT(6) antagonists, reversed these cognitive deficits. These observations suggest that recruitment of mTOR by prefrontal 5-HT(6) receptors contributes to the perturbed cognition in schizophrenia, offering new vistas for its therapeutic control.
Copy elimination in functional languages (1989)

Copy elimination is an important optimization for compiling functional languages. Copies arise because these languages lack the concepts of state and variable; hence updating an object involves a copy in a naive implementation. Copies are also possible if proper targeting has not been carried out inside functions and across function calls. Targeting is the proper selection of a storage area for evaluating an expression. By abstracting a collection of functions by a target operator, we compute targets of function bodies that can then be used to define an optimized interpreter to eliminate copies due to updates and copies across function calls. The language we consider is typed lambda calculus with higher-order functions and special constructs for array operations. Our approach can eliminate copies in divide and conquer problems like quicksort and bitonic sort that previous approaches could not handle.
ChemInform Abstract: Therapeutic Opportunities for Muscarinic Receptors in the Central Nervous System (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.