gebhart/patrepeval huggingface dataset:
Calibration of polarimetric PHARUS data (1998)

This paper presents a procedure for the calibration of polarimetric PHARUS data, based on the JPL POLCAL
Cyclic poly(<i>ε</i>‐caprolactone) synthesized by combination of ring‐opening polymerization with ring‐closing metathesis, ring closing enyne metathesis, or “click” reaction (2009)

Abstract This article described the synthesis of cyclic poly(ε‐caprolactone) (PCL) via ring‐closing metathesis (RCM), ring closing enyne metathesis (RCEM), and “click” reaction of different difunctional linear PCL. Linear PCL precursors were prepared by ring‐opening polymerization (ROP) of ε‐caprolactone in bulk using 10‐undecen‐1‐ol or propargyl alcohol as the initiator, followed by reacting with corresponding acyl chloride containing vinyl or azido end group. The subsequent end‐to‐end intramolecular coupling reactions were performed under high dilution conditions. The successful transformation of linear PCL precursor to cyclic PCL was confirmed by Gel permeation chromatography, 1 H NMR, and Fourier transform infrared measurements. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 3022–3033, 2009
System needs for dispersion compensation (2002)

In WDM systems, nonlinear cross talk such as four wave mixing (FWM) and SRS can be reduced by a nonzero local dispersion, which either reduces the walk-off distance of channel-by-channel nonlinear interactions or increases the phase mismatch for FWM.
Effects of Topical Application of a Calcium Antagonist (Nifedipine) on Feline Cortical Pial Microvasculature under Normal Conditions and in Focal Ischemia (1983)

Cat cortical arterioles and venules were exposed in vivo to the Ca2+ antagonist nifedipine under normal conditions and in focal ischemia. Topical application of nifedipine caused a marked, concentration-dependent arteriolar dilatation. The dilatatory responses increased significantly with decreasing arteriolar size. Perivenular microapplication of nifedipine invariably caused dilatation that was less pronounced but more long-lasting than that on the arteriolar side. Arterioles, which constricted after middle cerebral artery occlusion, invariably dilated following nifedipine application. These dilatatory responses were transient but could be repeated, and on some occasions were accompanied by a return of flow in vessels in which stasis had been present. The results suggest that nifedipine is able to dilate cerebral vessels both under normal conditions and when contracted during focal ischemia.
Urinary lipocalin‐2 is associated with renal disease activity in human lupus nephritis (2007)

The high prevalence of LN in SLE patients and the prognostic significance of kidney disease support the need for identifying early biomarkers to assess the risk of nephritis development and for following up patients with established disease. These findings indicate that urinary lipocalin-2 is a potential marker of the presence and severity of renal involvement in adult patients with SLE.
Assessing angiogenic responses induced by primary human prostate stromal cells in a three-dimensional fibrin matrix assay (2016)

Accurate modeling of angiogenesis in vitro is essential for guiding the preclinical development of novel anti-angiogenic agents and treatment strategies. The formation of new blood vessels is a multifactorial and multi-stage process dependent upon paracrine factors produced by stromal cells in the local microenvironment. Mesenchymal stem cells (MSCs) are multipotent cells in adults that can be recruited to sites of inflammation and tissue damage where they aid in wound healing through regenerative, trophic, and immunomodulatory properties. Primary stromal cultures derived from human bone marrow, normal prostate, or prostate cancer tissue are highly enriched in MSCs and stromal progenitors. Using conditioned media from these primary cultures, a robust pro-angiogenic response was observed in a physiologically-relevant three-dimensional fibrin matrix assay. To evaluate the utility of this assay, the allosteric HDAC4 inhibitor tasquinimod and the anti-VEGF monoclonal antibody bevacizumab were used as model compounds with distinct mechanisms of action. While both agents had a profound inhibitory effect on endothelial sprouting, only bevacizumab induced significant regression of established vessels. Additionally, the pro-angiogenic properties of MSCs derived from prostate cancer patients provides further evidence that selective targeting of this population may be of therapeutic benefit.
An efficient time domain solver for the acoustic wave equation (2012)

An efficient numerical solver for time domain solution of the wave equation for the purpose of propagation in small and large acoustic spaces is presented. It is based on the adaptive rectangular decomposition technique that subdivides a space into rectangular partitions and within each partition utilizes the analytical solution of the wave equation for spatially invariant speed of sound. This technique allows numerical computations in kilohertz range for auralization and visualization purposes. This can help engineers to quickly locate geometric features responsible for acoustical defects in practical engineering applications like noise control. It is demonstrated that by carefully mapping all the components of the technique on the GPU architecture, significant improvement in performance can be achieved while maintaining accuracy comparable to a high-order finite difference time domain (FDTD) solver. It is an order of magnitude faster than corresponding CPU-based solver and three orders of magnitude faster than the CPU-based FDTD solver. This technique can perform a 1 s long simulation on complex-shaped 3D scenes of air volume 7500 cu m till 1650 Hz within 18 min on a desktop machine. The ideal session for this work is “Computational Acoustics”.
Attachment, growth, and activity of rat osteoblasts on polylactide membranes treated with various low‐temperature radiofrequency plasmas (2005)

Nonporous and porous membranes from poly(L/DL-lactide) 80/20% were treated with low-temperature oxygen, ammonia, or sulphur dioxide-hydrogen plasmas and the late effects of plasma treatment on physicochemical characteristics of the membranes' surface were analyzed. The plasma treatment resulted in the permanent attachment of sulphur and nitrogen functionalities to the membrane's surface, and increased the surface concentration of oxygen, thereby increasing the surface wettability. To assess whether the plasma treatment affects the cellular response, primary rat osteoblasts were cultured on nontreated and plasma-treated nonporous and microporous membranes, and attachment, growth, and activity of cells were investigated. It was found that attachment and growth of osteoblasts on all the plasma-treated membranes were greater compared with nontreated controls. The treatment with ammonia plasma was most efficacious. The beneficial effects of plasma treatment on cells were most pronounced for microporous polylactide membranes irrespective of the plasma used. The results of the study suggest that the treatment of porous polylactide structures with plasma can be an effective means of enhancing their suitability for tissue engineering. Plasma exposure may also have an advantageous effect on bone healing when polylactide membranes are used to treat bone defects.
Optical fiber nanowires and microwires: fabrication and applications (2009)

Microwires and nanowires have been manufactured by using a wide range of bottom-up techniques such as chemical or physical vapor deposition and top-down processes such as fiber drawing. Among these techniques, the manufacture of wires from optical fibers provides the longest, most uniform and robust nanowires. Critically, the small surface roughness and the high-homogeneity associated with optical fiber nanowires (OFNs) provide low optical loss and allow the use of nanowires for a wide range of new applications for communications, sensing, lasers, biology, and chemistry. OFNs offer a number of outstanding optical and mechanical properties, including (1) large evanescent fields, (2) high-nonlinearity, (3) strong confinement, and (4) low-loss interconnection to other optical fibers and fiberized components. OFNs are fabricated by adiabatically stretching optical fibers and thus preserve the original optical fiber dimensions at their input and output, allowing ready splicing to standard fibers. A review of the manufacture of OFNs is presented, with a particular emphasis on their applications. Three different groups of applications have been envisaged: (1) devices based on the strong confinement or nonlinearity, (2) applications exploiting the large evanescent field, and (3) devices involving the taper transition regions. The first group includes supercontinuum generators, a range of nonlinear optical devices, and optical trapping. The second group comprises knot, loop, and coil resonators and their applications, sensing and particle propulsion by optical pressure. Finally, mode filtering and mode conversion represent applications based on the taper transition regions. Among these groups of applications, devices exploiting the OFN-based resonators are possibly the most interesting; because of the large evanescent field, when OFNs are coiled onto themselves the mode propagating in the wire interferes with itself to give a resonator. In contrast with the majority of high-Q resonators manufactured by other means, the OFN microresonator does not have major issues with input-output coupling and presents a completely integrated fiberized solution. OFNs can be used to manufacture loop and coil resonators with Q factors that, although still far from the predicted value of 10. The input-output pigtails play a major role in shaping the resonator response and can be used to maximize the Q factor over a wide range of coupling parameters. Finally, temporal stability and robustness issues are discussed, and a solution to optical degradation issues is presented.
Spontaneous Interferon Production and Epstein-Barr Virus Antigen Expression in Human Lymphoid Cell Lines (1975)

Established human lymphoid cell lines, many of which spontaneously produce interferon, differ in the efficiency by which they allow expression of Epstein-Barr virus (EBV) lytic functions. Six EBV carrying lymphoid cell lines, selected to either be extremely susceptible or very refractory to EBV superinfection, were tested for spontaneous interferon production. Only the three cell lines which were poorly superinfectable with EBV were found to produce interferon. These same three lines could not be induced to express EBV-specific early antigens from intrinsic EBV genomes. It is suggested that interferon acts as a negative control factor affecting a cell's susceptibility to EBV.
Modelling the Perception of Musical Sequences with Self-organizing Neural Networks (1994)

A brief review of studies into the psychology of melody perception leads to the conclusion that melodies are represented in long-term memory as sequences of specific items, either intervals or scale notes; the latter representation is preferred. Previous connectionist models of musical-sequence learning are discussed and criticized as models of perception. The Cohen— Grossberg masking field (Cohen & Grossberg, 1987) is described and it is shown how it can be used to generate melodic expectations when incorporated within an adaptive resonance architecture. An improved formulation, the SONNET 1 network (Nigrin, 1990, 1992), is described in detail and modifications are suggested. The network is tested on its ability to learn short melodic phrases taken from a set of simple melodies, before being applied to the learning of the melodies themselves. Mechanisms are suggested for sequence recognition and sequence recall. The advantages of this approach to sequence learning are discussed.
Spatial scaling of central and peripheral contrast-sensitivity functions (1987)

Contrast sensitivity was measured as a function of spatial frequency at various eccentricities in the nasal visual field. Eccentricity influenced resolution more for vertical gratings than for horizontal ones, demonstrating a nasal field anisotropy. When grating apertures and spatial frequencies were varied together, by changing viewing distance, peripheral and central contrast-sensitivity functions could not be entirely superimposed by scaling the spatial-frequency stimulus parameter. However, when gratings apertures were designed to project a standard-sized patch on a hypothetical vertical surface at an angle of 9 deg to the line of sight, the superimposition of central and peripheral contrast-sensitivity functions improved. Central and peripheral contrast-sensitivity functions can be superimposed by describing the grating stimulus with reference to this putative surface in terms of cycles per surface distance. The surface-scaling approach leaves a minor effect of eccentricity on contrast sensitivity for vertical gratings but readily accommodates the vertical-horizontal anisotropy in grating resolution. These findings suggest a novel functional role for gradients in the spatial sampling of the visual field, in relation to the internal representation of the structure and geometry of visible surfaces.
Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. (1992)

LPS Activation of MAP Kinases in Macrophagesdifferent MAP kinase isozymes.Thus, MAP kinases are the first identified substrates for LPS-induced tyrosine phosphorylation.
Growth of Mycoplasma synoviae in a medium supplemented with nicotinamide instead of B-nicotinamide adenine dinucleotide. (1975)

The cultivation of Mycoplasma synoviae (MS) on growth medium requires supplementation with B-nicotinamide adenine dinucleotide (NAD), an expensive and relatively unstable compound. Strains of MS were adapted (selected) to grow in a medium supplemented instead with nicotinamide, a stable and inexpensive substance that can be heat-sterilized in the medium without impairing its growth-promoting properties. MS plate agglutinating antigens grown in nicotinamide-enriched media were comparable in yield and serological reaction to antigens grown with NAD supplementation.
Comparison of intestinal mast cell and basophil histamine release in children with food allergic reactions (1989)

The in vitro histamine release response of human intestinal mast cells and basophils challenged with anti-IgE, Concanavalin A, ionophore A23187 and food extracts was compared with skin prick test, RAST analysis and open food challenge. It was not possible to perform food challenge in all patients; however, seven children underwent open food challenge and in five the clinical diagnosis of "true" food allergy was confirmed. The intestinal mast cells were pooled from enzymatically dispersed duodenal biopsies obtained by duodenoscopy from 15 selected children suspected of food allergy, and five age-matched controls. In nine of 10 patients classified as "food allergic" intestinal mast cells released histamine to various food extracts in a dose-dependent fashion. From the mast cells of the nine food-allergic patients compared with non-allergics, the anti-IgE mediated mast cell histamine release was increased. Additionally, at 1000 U/ml anti-IgE the mast cell histamine release was increased compared with their corresponding basophils. However, in non-allergic subjects the histamine release of basophils was increased compared with their corresponding mast cells. Histamine release from basophils was positively correlated to the test scores of the RAST analysis, skin prick test, and food challenge. No apparent correlation between tests scores obtained from histamine release of intestinal mast cell and the other tests was demonstrated, except in children with diarrhoea as only symptom. However, the study gives evidence that duodenal mast cells actually are sensitized with specific IgE and thus may play a pathophysiological role in food hypersensitivity. In addition, the study shows that the ability of different stimuli, including food extracts, to trigger basophil histamine release does not correlate with their potency to induce histamine release from mast cells.
Amylin inhibits bone resorption by a direct effect on the motility of rat osteoclasts (1993)

We have performed a set of independent studies on the effects of the circulating pancreatic polypeptide, amylin, on rat osteoclast function, in vitro. Time-lapse video observations, measuring cell protrusions and retraction, showed that 250 nmol l-1 amylin or 250 nmol l-1 beta-calcitonin gene-related peptide (beta-CGRP) inhibited osteoclast motility (quiescence or Q effect). Both amylin and beta-CGRP produced inhibitory responses with a significant first-order regression over time (half-times, 19 and 28 min respectively). In contrast, 250 nmol l-1 amylin or 250 nmol l-1 beta-CGRP produced no change of osteoclast spread area, whilst 300 pmol l-1 calcitonin (CT) application resulted in cell retraction (R effect). Forskolin (10 mumol l-1) mimicked amylin and CGRP in inhibiting osteoclast motility (half-time, 8.6 min), and similarly lacked an effect on cell spread area. Neither amylin nor beta-CGRP (62.5-1250 nmol l-1) elevated cytosolic free calcium levels ([Ca2+]i) in single osteoclasts whilst 300 pmol l-1 salmon calcitonin (sCT) produced a rapid phasic elevation of [Ca2+]i, confirming previous results with asusuberic (1-7) eel calcitonin. The osteoclast-bone resorption assay revealed the following potency difference in direct comparison of the area of resorption per bone slice: beta-CGRP/amylin, 0.1; sCT/amylin, 800 and human CT/amylin, 12. The potency of deamidated amylin approached that of beta-CGRP. Assay precision ranged between 0.3 and 0.8. Amylin (250 nmol l-1) also significantly (P < 0.05) reduced supernatant (tartrate-resistant) acid phosphatase in the bone-osteoclast cultures. These measures independently indicate an effect of amylin on osteoclast motility through mechanisms distinct from those of calcitonin, possibly through different selectivities for receptor subtypes, the cyclic AMP-linked 'amylin subtype' and the [Ca2+]i-linked 'calcitonin subtype'.
Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production (1997)

T cell receptor zeta (TcRzeta)/CD3 ligation initiates a signaling cascade that involves src kinases p56(lck) and zeta-associated protein 70, leading to the phosphorylation of substrates such as TcRzeta, Vav, SH2-domain-containing leukocyte protein 76 (SLP-76), cbl, and p120/130. FYN binding protein (FYB or p120/130) associates with p59(fyn), the TcRzeta/CD3 complex, and becomes tyrosine-phosphorylated in response to receptor ligation. In this study, we report the cDNA cloning of human and murine FYB and show that it is restricted in expression to T cells and myeloid cells and possesses an overall unique hydrophilic sequence with several tyrosine-based motifs, proline-based type I and type II SH3 domain binding motifs, several putative lysine/glutamic acid-rich nuclear localization motifs, and a SH3-like domain. In addition to binding the src kinase p59(fyn), FYB binds specifically to the hematopoietic signaling protein SLP-76, an interaction mediated by the SLP-76 SH2 domain. In keeping with this, expression of FYB augmented interleukin 2 secretion from a T cell hybridoma, DC27.10, in response to TcRzeta/CD3 ligation. FYB is therefore a novel hematopoietic protein that acts as a component of the FYN and SLP-76 signaling cascades in T cells.
Superresolution of three-dimensional optical imaging by use of evanescent waves (2004)

We simulate a three-dimensional optical diffraction tomography experiment in which superresolution is achieved by illuminating the object with evanescent waves generated by a prism. We show that accounting for multiple scattering between the object and the prism interface is mandatory to obtain superresolved images. Because the Born approximation leads to poor results, we propose a nonlinear inversion method for retrieving the map of permittivity of the object from the scattered far field. We analyze the sensitivity to noise of our algorithm and point out the importance of using incident propagative waves together with evanescent waves to improve the robustness of the reconstruction without losing the superresolution.
Machining of Micro Dimples in Milling for Functional Surfaces (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Takashi Matsumura, Satoru Takahashi; Machining of Micro Dimples in Milling for Functional Surfaces. AIP Conf. Proc. 4 May 2011; 1353 (1): 567–572. https://doi.org/10.1063/1.3589575 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Sorbitol Instant an Excipient with Unique Tableting Properties (1986)

The manifold tableting applications of sorbitol instant - a special type of spray-dried sorbitol - are described and numerous examples of tablet formulations are given. It is shown that the unique tableting properties of sorbitol instant chiefly result from its crystalline structure, which consists of very loosely-packed, randomly oriented, interwoven filamentary crystals. Due to the large compressibility of sorbitol instant, tablet formulations for low-dose as well as for high-dose drugs are relatively simple. Even though tablet disintegration is slower compared to standard formulations based on lactose, drug dissolution can be optimized in most cases by the proper selection of the disintegrant. Compared to crystalline sorbitol, sorbitol instant is a more universal tablet binder.Sorbitol instant is an example showing that the tableting characteristics of a chemical substance can be improved by adequately altering its physical and mechanical properties.
Antioxidative Polyphenols Isolated from <i>Theobroma </i><i>cacao</i> (1998)

The antioxidant components of cacao liquor, which is a major ingredient of chocolate, were isolated with column chromatography and high-performance liquid chromatography. Quercetin and its glucoside were identified by spectrometric methods. Clovamide and deoxyclovamide were characterized by (1)H and (13)C NMR and MS spectrometry. Their antioxidative activity was measured by peroxide value of linoleic acid and thiobarbituric acid reactive-substance value of erythrocyte ghost membranes and microsomes. In the bulk oil system, clovamide had the strongest antioxidative activity but was less active in the other experiments. In the case of the two hydrophilic systems, flavans such as quercetin and epicatechin were more potently effective than the glucosides. It is considered that chocolate is stable against oxidative deterioration due to the presence of these polyphenolic compounds.
Tacrolimus (FK506) Attenuates Leukocyte Accumulation After Transient Retinal Ischemia (1998)

The present study demonstrated the inhibitory effect of tacrolimus on leukocyte rolling and on subsequent leukocyte accumulation and the therapeutic potency to neural injury after transient retinal ischemia.