gebhart/patrepeval huggingface dataset:
Novel Alkaloids from the Sponge Batzella sp.: Inhibitors of HIV gp120-Human CD4 Binding (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel Alkaloids from the Sponge Batzella sp.: Inhibitors of HIV gp120-Human CD4 BindingAshok D. Patil, N. Vasant Kumar, Wilhelmus C. Kokke, Mark F. Bean, Alan J. Freyer, Charles De Brosse, Shing Mai, Alemseged Truneh, Brad Carte, and Cite this: J. Org. Chem. 1995, 60, 5, 1182–1188Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/jo00110a021https://doi.org/10.1021/jo00110a021research-articleACS PublicationsRequest reuse permissionsArticle Views1444Altmetric-Citations514LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Oral immunoadjuvant activity of<i>Lactobacillus casei</i>subsp.<i>casei</i>in dextran-fed layer chickens (2006)

We recently reported that synbiotic Lactobacillus casei subsp. casei together with specific substrate dextran elicited an enhancement in humoral immune response against bovine serum albumin (BSA) as a model antigen in BALB/c mice. The present study was designed to evaluate the oral immunoadjuvant effects of the synbiotic in layer chickens. Using a PCR assay, L. casei subsp. casei was detected specifically in the intestinal chyme of chickens (10 d of age, Julia strain) fed ad libitum on a diet supplemented with 75 mg dextran/kg (dextran-supplemented diet, DSD) and administered orally with 10(7) colony-forming units (CFU) L. casei subsp. casei in 0.1 ml PBS with the aid of an intubation needle at 1, 2 and 3 d of age. Furthermore, oral administration of 10(7) CFU L. casei subsp. casei at 1-3 d of age significantly enhanced the production of anti-BSA antibody in DSD-fed chickens (60 d of age) administered orally with 1 mg BSA at 32 and 33 d of age and subcutaneously with 5 microg BSA at 33 d of age. In addition, among bacterial numbers tested, 10(6) CFU L. casei subsp. casei together with dextran induced an effective increase in humoral immune response to mixed inactivated vaccines against Newcastle disease and avian infectious bronchitis, and the treatment may be advantageous in protecting against these infectious diseases in chickens in actual application. These results suggest that dietary supplementation of L. casei subsp. casei with dextran leads to immunomodulation of humoral immune responses.
Incidence, Symptoms and Signs, Results of Survey (1934)

No AccessJournal of Urology1 Feb 1934Incidence, Symptoms and Signs, Results of Survey Lang W. Anderson Lang W. AndersonLang W. Anderson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)72401-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1934 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByAllegra S, Broderick P and Corvese N (2018) Cytologic and Histogenetic Observations in Well Differentiated Transitional Cell Carcinoma of BladderJournal of Urology, VOL. 107, NO. 5, (777-782), Online publication date: 1-May-1972. Volume 31Issue 2February 1934Page: 148-154 Advertisement Copyright & Permissions© 1934 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Lang W. Anderson More articles by this author Expand All Advertisement Loading ...
Safety and Immunogenicity of<i>Shigella sonnei</i>and<i>Shigella flexneri</i>2a O‐Specific Polysaccharide Conjugates in Children (1999)

O-specific polysaccharide conjugates of shigellae were safe and immunogenic in young adults, and a Shigella sonnei conjugate conferred protection [1-3]. Shigellosis is primarily a disease of children; therefore, the safety and immunogenicity of S. sonnei and Shigella flexneri 2a conjugates were studied in 4- to 7-year-old children. Local and systemic reactions were minimal. The first injection of both conjugates elicited significant rises in geometric mean levels of serum IgG only to the homologous lipopolysaccharide (LPS) (S. sonnei, 0.32-8.25 ELISA units [EU]; S. flexneri 2a, 1.15-20.5 EU; P<.0001). Revaccination at 6 weeks induced a booster response to S. flexneri 2a LPS (20.5-30.5 EU, P=.003). Six months later, the geometric mean levels of IgG anti-LPS for both groups were higher than the prevaccination levels (P<.0001). Similar, but lesser, rises were observed for IgM and IgA anti-LPS. The investigational Shigella conjugates were safe and immunogenic in children and merit evaluation of their efficacy.
An Expedient Synthesis of Ethyl 4(5)-Alkyl(aryl)thioimidazole-5(4)-carboxylate (1995)

Various ethyl 4-alkyl(aryl)thioimidazole-5-carboxylates have been synthesized by the reaction of ethyl valeramidocyanoacetate with a variety of alkyl(aryl) thiols in the presence of triethylamine and subsequent phosphorus pentachloride/4-dimethylaminopyridine (DMAP) mediated cyclization of the acyclic intermediates.
Molecular Cloning and Ethylene Induction of mRNA Encoding a Phytoalexin Elicitor-Releasing Factor, β-1,3-Endoglucanase, in Soybean (1990)

Soybean (Glycine max) beta-1,3-endoglucanase (EC 3.2. 1.39) is involved in one of the earliest plant-pathogen interactions that may lead to active disease resistance by releasing elicitor-active carbohydrates from the cell walls of fungal pathogens. Ethylene induced beta-1,3-endoglucanase activity to 2- to 3-fold higher levels in cotyledons of soybean seedlings. A specific polyclonal antiserum raised against purified soybean beta-1,3-endoglucanase was used to immunoprecipitate in vitro translation products, demonstrating that ethylene induction increased translatable beta-1,3-endoglucanase mRNA. Several cDNA clones for the endoglucanase gene were obtained by antibody screening of a lambda-gt11 expression library prepared from soybean cotyledons. Hybrid-select translation experiments indicated that the cloned cDNA encoded a 36-kilodalton precursor protein product that was specifically immunoprecipitated with beta-1,3-endoglucanase antiserum. Escherichia coli cells expressing the cloned cDNA also synthesized an immunologically positive protein. Nucleotide sequence of three independent clones revealed a single uninterrupted open reading frame of 1041 nucleotides, corresponding to a polypeptide of 347 residue long. The primary amino acid sequence of beta-1,3-endoglucanase as deduced from the nucleotide sequence was confirmed by direct amino acid sequencing of trypsin digests of the glucanase. The soybean beta-1,3-endoglucanase exhibited 53% amino acid homology to a beta-1,3-glucanase cloned from cultured tobacco cells and 48% homology to a beta-(1,3-1,4)-glucanase from barley. Utilizing the largest cloned cDNA (pEG488) as a hybridization probe, it was found that the increase in translatable beta-1,3-endoglucanase mRNA seen upon ethylene treatment of soybean seedlings was due to 50- to 100-fold increase in steady state mRNA levels, indicating that ethylene regulates gene expression of this enzyme important in disease resistance at the level of gene transcription.
Controlled autoignition of hydrogen in a direct-injection optical engine (2012)

Research into novel internal combustion engines requires consideration of the diversity in future fuels in an attempt to reduce drastically CO2 emissions from vehicles and promote energy sustainability. Hydrogen has been proposed as a possible fuel for future internal combustion engines and can be produced from renewable sources. Hydrogen’s wide flammability range allows higher engine efficiency than conventional fuels with both reduced toxic emissions and no CO2 gases. Most previous work on hydrogen engines has focused on spark-ignition operation. The current paper presents results from an optical study of controlled autoignition (or homogeneous charge compression ignition) of hydrogen in an engine of latest spark-ignition pentroof combustion chamber geometry with direct injection of hydrogen (100 bar). This was achieved by a combination of inlet air preheating in the range 200–400 °C and residual gas recirculated internally by negative valve overlap. Hydrogen fuelling was set to various values of equivalence ratio, typically in the range ϕ = 0.40–0.63. Crank-angle resolved flame chemiluminescence images were acquired for a series of consecutive cycles at 1000 RPM in order to calculate in-cylinder rates of flame expansion and motion. Planar Laser Induced Fluorescence (LIF) of OH was also applied to record more detailed features of the autoignition pattern. Single and double (i.e. ‘split’ per cycle) hydrogen injection strategies were employed in order to identify the effect of mixture preparation on autoignition’s timing and spatial development. An attempt was also made to review relevant in-cylinder phenomena from the limited literature on hydrogen-fuelled spark-ignition optical engines and make comparisons were appropriate.
The impact of persecution upon the Igreja Evangelica Congregacional in Angola 1950-1974 : research in progress (2008)

My interest in the research stems from personal experience of a warring Angola during the 1980's. Growing up in Angola, as anIgreja Evangelica Congregacional in Angola (IECA) pastor's son, I knew fear, social exclusion, and religious alienation. Much of the persecution which the IECA faced during this period of history can be ascribed to the impact of Marxism-Leninism, the political ideology adopted by the MPLA (Popular Movement for the Liberation of Angola) after independence in 1975.
Multi-hop scheduling algorithms in switches with reconfiguration latency (2006)

Optical switching fabrics (OSF) are receiving increasing attention in the design of high speed packet switches, due to their excellent properties in terms of available bandwidth and reduced power consumption. However, most optical devices suffer a reconfiguration latency each time input/output connections are modified; unfortunately, this latency may not be negligible with respect to the packet transmission time, and can adversely affect performance, especially delay and throughput. The multi-hop approach, i.e., sending packets to the final destination port exploiting transmission to intermediate ports, was shown to be a promising way to control the tradeoff between delay and throughput. In this paper, we examine the multi-hop approach when using a logical interconnections based on multidimensional regular topologies. We discuss not only the scheduling problem for these topologies, but also the design of routing and queueing schemes. Performance are analyzed by simulation
DNA Transformation of Mammalian Cells (2003)

The manipulation of gene sequences between cells is a fundamental technique in genetics. Mammalian cells will take up and express genes when they are exposed to either metaphase chromosomes or naked genomic or recombinant DNA. In each case the uptake and expression is enhanced by the formation of a DNA-calcium phosphate precipitate (1,2). Alternatively, cloned recombinant DNA sequences may be introduced directly into mammalian cells by fusion with bacterial protoplasts containing recombinant plasmids (3) or by microinjection of purified DNA directly into the cell's nucleus (4). In many cases the transforming DNA is stably expressed, and consequently alters the genotype of the recipient cell. Since long-term transformation is a relatively rare event, identification of this altered genotype requires the use of genes coding for selectable functions or for proteins easily assayable by single cell antibody or related techniques.
Hierarchical NiCo<sub>2</sub>O<sub>4</sub> nanosheet-decorated carbon nanotubes towards highly efficient electrocatalyst for water oxidation (2015)

With the synergistic effect of the oxidized carbon nanotubes, hierarchical NiCo<sub>2</sub>O<sub>4</sub> nanosheet-decorated carbon nanotubes exhibit superior OER catalytic performance.
Adaptive Weight Estimator for Quantum Error Correction in a Time‐Dependent Environment (Adv. Quantum Technol. 1/2018) (2018)

To execute algorithms on a quantum computer, one must prevent the accumulation of errors by monitoring and correcting them in control hardware. Repetition code and error correction are discussed by Stephen T. Spitz et al. in article number 1800012: To prevent collapse of the protected logical state, quantum error correction requires non-local parity checks. Errors cause correlated non-trivial results from these checks, which are matched to determine the underlying system state.
Treatment of Hypercholesterolemia with Nicotinic Acid (1958)

Nicotinic acid was administered orally to 33 patients with hypercholesterolemia in doses varying from 1.5 to 6.0 Gm. per day for periods of 3 months to 1½ years. Significant, sustained, and reproducible decreases in the concentration of cholesterol and total lipids in the plasma and of serum beta-lipoprotein cholesterol were observed in a majority of patients. This form of therapy appears to be effective, practical, and probably free from serious harmful effects.
Contrast enhanced ultrasound of breast cancer (2006)

The importance of ultrasound examination in the diagnosis of breast cancer has been widely demonstrated. During the last few years, the introduction of ultrasound contrast media has been considered a promising tool for studying the vascular pattern of focal lesions within the breast. Our purpose was to assess whether contrast-enhanced (CE) ultrasound examination, performed using specific contrast imaging modes, can be helpful for detection and characterization of breast lesions, and for prediction of the response of breast cancer to therapy.
A perceptually tuned subband image coder based on the measure of just-noticeable-distortion profile (2002)

To maintain high image quality with low bit-rates, an effective coding algorithm should not only remove statistical correlation but also perceptual redundancy from image signals. A subband coding scheme based on estimation and exploitation of just-noticeable-distortion (JND) profile is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
DNA Binding, Solubility, and Partitioning Characteristics of Extended Lexitropsins (2000)

Four new ligands that bind to the minor groove of DNA have been designed, synthesized, and evaluated by DNA footprinting. Two of the ligands are polyamides containing central regions with five or six N-methylpyrrole units, conferring hydrophobicity and good binding affinity but without retaining the correct spacing for hydrogen bonding in the base of the minor groove. The two remaining ligands have central regions which are head-to-head-linked polyamides, in which the linker is designed to improve the phasing of hydrogen bonding of the ligand with the floor of the minor groove. The highest affinity was obtained with the two polypyrroles without headgroup spacers, indicating that H-bond phasing is secondary in determining affinity compared to the major hydrophobic driving force. With a dimethylaminoalkyl group, representing a moiety with modest base strength, at both ends, water solubility is good and pH-partition theory predicts that penetration through lipid membranes will be enhanced, compared to strongly basic amidine analogues of the alkaloid precursors. All four compounds bind to DNA, with strong selectivity for AT sequences but some tolerance of GC base pairs and subtle individual preferences. The data show that very high affinities can be anticipated for future compounds in this series, but drug design must take account of overall physicochemical properties as well as the details of hydrogen bonding between ligands and the floor of the minor groove.
Design sketch for a million-element NETL machine (1980)

This paper describes (very briefly) a parallel hardware implementation for NETL-type semantic network memories. A million-element system can be built with about 7000 IC chips, including 4000 64K RAM chips. This compares favorably with the hardware cost of holding the same body of knowledge in a standard computer memory, and offers significant advantages in flexibility of access and the speed of performing certain searches and deductions. 1.
The simulation of 3D microcalcification clusters in 2D digital mammography and breast tomosynthesis (2011)

The realistic appearance of the 3D models of microcalcification clusters, whether malignant or benign clusters, was confirmed for 2D digital mammography images and the breast tomosynthesis datasets; this database of clusters is suitable for use in future observer performance studies related to the detectability of microcalcification clusters. Such studies include comparing 2D digital mammography to breast tomosynthesis and comparing different reconstruction algorithms.
An Efficient Energy Management System for Android Phone Using Bayesian Networks (2012)

Many applications on smart phones have been developed for a user's convenience. They are using various sensors such as accelerometer, proximity, light and orientation sensors for context-awareness. Energy-efficient battery management systems become more important to support the sensors on a mobile phone because recent applications consume a large amount of energy for diverse functionalities. This paper proposes a context-aware battery management system which infers a user's situation and controls unnecessary functionalities using embedded sensors on a mobile phone. The proposed system uses probabilistic models to infer a user's situation and minimizes the cost of probability calculation according to the change of context. In order to show the feasibility of the proposed method, we conducted the evaluation with a real dataset collected from mobile device.
ID-based Weak Blind Signature from Bilinear Pairings (2008)

In a blind signature scheme, the user can get a signature sig(m) on message m generated from the signer’s blind signature sig(m ′ ) on blinded message m ′ , but the signer can’t know the contents of the message m. When the signature sig(m) is revealed to public after that have been signed, if the signer can find the linkage between the signature sig(m) and the blind signature sig(m ′ ) on blinded message m, the signature is called as weak blind signature, otherwise, called as strong blind signature. In this paper, by using the bilinear pairings, a new ID-based weak blind signature was proposed, which is based on the Discrete Logarithm Problem and Gap Diffie-Hellman Problem. The proposed scheme use ID-based public key instead of public key of digital certification, can effectively simplify the procedure of public key management and reduce the disk storage space. In addition, by choosing different equations, we gained corresponding weak blind signature schemes respectively. Finally, the security of the proposed scheme was discussed. Keywords: bilinear pairings, ID-based cryptosystem, strong blind signature, weak blind signature 1
Rational combinatorial design of pore-forming β-sheet peptides (2005)

Exogenous polypeptides that self-assemble on biological membranes into pores are abundant and structurally diverse, functioning as transporters, toxins, ion channels, and antibiotics. A means for designing novel pore-forming sequences would unlock new opportunities for the development and engineering of protein function in membranes. Toward this goal, we designed a 9,604-member rational combinatorial peptide library based on the structural principles of known membrane-spanning beta-sheets. When the library was screened under stringent conditions for sequences with pore-forming activity, a single active motif was found, which is characterized by aromatic residues at the lipid-exposed interfacial positions and basic residues in the pore-lining portion of the sequence. Peptides with this motif assembled on bilayer membranes into beta-sheets and formed transient peptide/lipid pores of approximately 1-nm diameter. The mechanism of action is very similar to that of natural, pore-forming peptides. These methods provide a powerful means for selecting and engineering novel pore-forming sequences and will open prospects for designing peptide antibiotics, biosensors, and new membrane protein structures.
Synthesis of site-heterologous haptens for high-affinity anti-pyraclostrobin antibody generation (2010)

The design and synthesis of functional chemical derivatives of small organic molecules is usually a key step for the intricate production of a variety of bioconjugates. In this respect, the derivatization site at which the spacer arm is introduced in immunizing conjugates constitutes a highly critical parameter for the generation of high-affinity and selective antibodies. However, due to the usual complexity of the required synthetic procedures, the appropriate comparison of alternative tethering positions has often been neglected. In the present study, meticulous strategies were followed to prepare synthetic derivatives of pyraclostrobin with the same linkers located at diverse rationally-chosen sites. Activity appraisal of antibodies and bioconjugates was carried out by bidimensional competitive direct and indirect immunoassays, and a superior performance of two of the three synthesized haptens was found. Finally, a detailed analysis of the conformations of the target molecule and the synthesized haptens in aqueous solution was done using computer assisted molecular modeling techniques. This study suggested that the lower titers and affinities of one set of antibodies are most probably due to conformational effects of the spacer arm in the immunizing bioconjugate.
Highly efficient all-screen-printed back-contact back-junction silicon solar cells with aluminum-alloyed emitter (2011)

All-screen-printed back-contact back-junction silicon solar cells with aluminum-alloyed emitter on n-type base material were fabricated and analyzed at Fraunhofer ISE PV-TEC. Three different process sequences are compared to each other. One process flow with shallow phosphorus profiles realizes cells with efficiencies of 19.7%. Using a long thermal oxidation, cells with deep driven-in phosphorus profiles (front and back surface field) were processed where solar cell efficiencies of 20.0% are realized. Both cell efficiencies are independently measured at Fraunhofer ISE CalLab on a designated area of 16.65 cm2. The specific contact resistivity of screen-printed and fired silver paste to silicon surfaces with different phosphorus profiles was determined in dependence of several firing conditions. The main developed features of the presented cell structure comprise the firing-stable front and rear passivation layers, the spiking-free passivation layer against aluminum and the deep driven-in phosphorus profile that can be contacted by silver screen-printing paste in a firing step.