gebhart/patrepeval huggingface dataset:
Immobilization of Radioactive Wastes in Hydrothermal Synthetic Rock, (II) (1984)

Click to increase image sizeClick to decrease image sizeKEYWORDS: pollucitehydrothermal synthesiscesiumimmobilizationsiliceous sinterradioactive wastes
[Design and implementation of DB sequence optimization software]. (2006)

TIR (Translation Initiation Region) efficiency is very important in prokaryotic expression. The TIR's efficiency is highly dependent on SD (Shine-Dalgarno) sequence, distance between SD sequence and start codon, DB (Downstream Box) sequence, TIR's second structure, codon adaptation and so on. In this paper, we designed and implemented the software to optimize DB sequence and 5' rare codons. It generated some optimization sequences by analyzing the target sequence and comparing it with 16S RNA. And the optimization sequences is sorting by number of base pairing, location of base pairing and codon adaptation. We drew up the algorithm and the core of code in this paper.
A Data Mining Approach for Cache Replacement in Location-Dependent Environment (2010)

With the extensive popularity of mobile devices, a huge amount of research effort has been attempted towards exploring several aspects of mobile computing. In the light of many applications such as traffic conditions, stock information, weather reports and most importantly location dependent services - that require processing of location dependent queries - this area of research has gained much importance. A mobile server is expected to concurrently serve many clients. Periodic broadcasting is an important method for data dissemination in a mobile environment and is also independent of the number of users. Caching frequently accessed data items in location dependent environment for making adaptive updates, is a better method to exploit broadcasting strategy. The location dependent aspect along with the temporal aspect of the data, if applied intelligently in caching the data, is expected to give a better performance for accessing data and improving cache consistency. In this paper we intend to give, a method of predictive prefetching of data, obtained after processing the past references, to derive the probability of future access based on data mining techniques, that is expected to improve the performance of data retrieval in location-dependent environment thus providing efficient mobility management. This paper gives a data mining approach for performing cache replacement that gives accurate predictions and can also improve the system performance.
The Efficacy of Different Commercially Available Demineralized Bone Matrix Substances in an Athymic Rat Model (2005)

Significant differences exist among commercially available DBMs in forming a spinal fusion in an athymic rat.
Thiazolidinediones inhibit MDCK cyst growth through disrupting oriented cell division and apicobasal polarity (2011)

Thiazolidinediones have been reported to retard cystic disease in rodent models by uncertain mechanisms. We hypothesized that their major effect in retarding cystogenesis was through inhibiting cell proliferation or stimulating apoptosis. In the Madin-Darby canine kidney cell (MDCK) model, rosiglitazone inhibited cyst growth in a time- and dose-dependent manner and this was accompanied by a reduction in basal proliferation and an increase in apoptosis. Unexpectedly, we also observed a striking abnormality in lumen formation resulting in a characteristic multiple lumen or loss of lumen phenotype in treated cells at doses which did not inhibit cell proliferation. These changes were preceded by mislocalization of gp135 and Cdc42, misorientation of the mitotic spindle, and retardation in centrosome reorientation with later changes in primary cilia length and mislocalization of E-cadherin. Cdc42 activation was unaffected by rosiglitazone in monolayer culture but was profoundly inhibited in three-dimensional culture. MDCK cells stably expressing mutant Cdc42 showed a similar mislocalization of gp135 expression and multilumen phenotype in the absence of rosiglitazone. We conclude that rosiglitazone influences MDCK cyst growth by multiple mechanisms involving dosage-dependent effects on proliferation, spindle orientation, centrosome migration, and lumen formation. Correct spatial Cdc42 activation is critical for lumen formation, but the effect of rosiglitazone is likely to involve both Cdc42 and non-Cdc42 pathways.
Thickness dependent conduction behavior of various particles for conductive adhesive applications (2002)

In order to gain insight into the film thickness dependent conduction behavior of adhesives containing conductive particles of different size, shape and type, the effect of adhesive film thickness was studied. Epon 830 resin was used as the base resin, and 4-7 /spl mu/m silver powder was used as the base particle for comparative purposes. Adhesive films of length 2.0 cm, and width 0.7 cm were cast subsequent to mixing with conductive particles in the amount of 25% by volume. The conductive particles were 100% Ag or 50% by weight mixture of Ag with Ni powder, flakes, or filaments. Silver coated Ni flakes of size 20 /spl mu/m were also mixed in 50% proportion with Ag powder to assess the effect of silver coating. Subsequent to cure, the resistance of the filled films was measured by the four-point method, and resistivities were calculated based on these measurements.
Chemically Driven Deformation of Polymers (1989)

Chemically driven deformation of polymer glasses is important in a variety of electronic packaging applications ranging from stripping of photoresists to diffusion of processing liquids into printed circuit boards. The swelling of such glasses by small molecules requires the deformation of polymer chains, a deformation that can be modelled as driven by an osmotic pressure. Equations governing the rate of this process are developed and the predictions are compared with the results of experiments in which the volume fraction φ of iodohexane (IOH) sorbed at the surface of polystyrene is measured as a function of exposure time. Once a critical φ is reached, a diffusion front develops and moves into the polymer at a constant velocity. The velocity V of this front can be predicted quantitatively from V=D(φm)a′(φm)a(φm)∂φ∂tφm where D is the diffusion coefficient of the IOH in the glass, a, and a′ are the activity of IOH and its derivative with respect to φ and the subscript m signifies that the quantities are evaluated at the volume fraction of the maximum osmotic pressure ahead of the front. The φ(t) and V predicted by a pressure dependent viscous swelling model for ∂φ/∂t are in good agreement with the experimental results at low IOH activities.
Probiotics Can Generate FoxP3 T-Cell Responses in the Small Intestine and Simultaneously Inducing CD4 and CD8 T Cell Activation in the Large Intestine (2013)

Most studies on probiotics aim to restore intestinal homeostasis to reduce immune-pathology in disease. Of equal importance are studies on how probiotics might prevent or delay disease in healthy individuals. However, knowledge on mechanisms of probiotic actions in healthy individuals is scarce. To gain more insight in how different bacterial strains may modulate the healthy intestinal immune system, we investigated the effect of the food derived bacterial strains L. plantarum WCFS1, L. salivarius UCC118, and L. lactis MG1363, on the intestinal regulatory immune phenotype in healthy mice. All three bacterial strains induced an upregulation of activity and numbers of CD11c(+) MHCII(+) DCs in the immune-sampling Peyer's Patches. Only L. salivarius UCC118 skewed towards an immune regulatory phenotype in the small intestinal lamina propria (SILP). The effects were different in the large intestine lamina propria. L. salivarius UCC118 induced activation in both CD4 and CD8 positive T-cells while L. plantarum WCFS1 induced a more regulatory phenotype. Moreover, L. plantarum WCFS1 decreased the Th1/Th2 ratio in the SILP. Also L. lactis MG1363 had immunomodulatory effects. L. lactis MG1363 decreased the expression of the GATA-3 and T-bet in the SILP. As our data show that contradictory effects may occur in different parts of the gut, it is recommended to study effects of probiotic in different sites in the intestine. Our strain-specific results suggest that unspecified application of probiotics may not be very effective. Our data also indicate that selection of specific probiotic strain activities on the basis of responses in healthy mice may be a promising strategy to specifically stimulate or suppress immunity in specific parts of the intestine.
Preprocessing of unconstrained quadratic binary optimization (2006)

We propose several efficient preprocessing techniques for Unconstrained Quadratic Binary Optimization (QUBO), including the direct use of enhanced versions of known basic techniques (e.g., implications derived from first and second order derivatives and from roof–duality), and the integrated use (e.g., by probing and by consensus) of the basic techniques. The application of these techniques is implemented using a natural network flow model of QUBO. The use of the proposed preprocessing techniques provides: (i) a lower bound of the minimum of the objective function, (ii) the values of some of the variables in some or every optimum, (iii) binary relations (equations, inequalities, or non-equalities) between the values of certain pairs of variables in some or every optimum, and (iv) the decomposition (if possible) of the original problem into several smaller pairwise independent QUBO problems. Extensive computational experience showing the efficiency of the proposed techniques is presented. Substantial problem simplifications, improving considerably the existing techniques, are demonstrated on benchmark problems as well as on randomly generated ones. In particular, it is shown that 100% data reduction is achieved using the proposed preprocessing techniques for MAX-CUT graphs derived from VLSI design, MAX-Clique in c-fat graphs derived from fault diagnosis, and minimum vertex cover problems in random planar graphs of up to 500 000 vertices. Acknowledgements: The third author was partially financially supported by the Portuguese FCT and by the FSE in the context of the III Quadro Comunitario de Apoio.
Domain motions in bacteriophage T4 lysozyme: A comparison between molecular dynamics and crystallographic data (1998)

A comparison of a series of extended molecular dynamics (MD) simulations of bacteriophage T4 lysozyme in solvent with X-ray data is presented. Essential dynamics analyses were used to derive collective fluctuations from both the simulated trajectories and a distribution of crystallographic conformations. In both cases the main collective fluctuations describe domain motions. The protein consists of an N- and C-terminal domain connected by a long helix. The analysis of the distribution of crystallographic conformations reveals that the N-terminal helix rotates together with either of these two domains. The main domain fluctuation describes a closure mode of the two domains in which the N-terminal helix rotates concertedly with the C-terminal domain, while the domain fluctuation with second largest amplitude corresponds to a twisting mode of the two domains, with the N-terminal helix rotating concertedly with the N-terminal domain. For the closure mode, the difference in hinge-bending angle between the most open and most closed X-ray structure along this mode is 49 degrees. In the MD simulation that shows the largest fluctuation along this mode, a rotation of 45 degrees was observed. Although the twisting mode has much less freedom than the closure mode in the distribution of crystallographic conformations, experimental results suggest that it might be functionally important. Interestingly, the twisting mode is sampled more extensively in all MD simulations than it is in the distribution of X-ray conformations.
Tunable cw passive mode- locked Ti:sapphire laser with direct pulse compression (1990)

Continuous wave passive mode-locking of a Ti:sapphire laser and direct compression of its output pulses without coupling into a fiber are described.
Task Analysis and Division of Responsibility in Physical Therapy (1971)

Physical therapy tasks are analyzed and a theoretical model of practice described as the basis for suggesting a systematic procedure for dividing responsibility among aides, assistants, and professional therapists. Application of the system and its implications are discussed in relation to such areas as overlapping competencies, communications, expressive functions, supervisory ratios and relationships, and interdependency.
Synthesis and Mesomorphic Properties of<i>m</i>-Cyano-or<i>m</i>-Halogeno-Benzoate Derivatives (1977)

Abstract Thirty four benzoate derivatives were prepared. They belong to the two following series: the 4-n-alkylphenyl 3-cyano-or 3-fluoro-4-n-alkoxybenzoates and the 4-n-alkylphenyl 4-(3-cyano-or 3-bromo-4-n-alkoxy-or 4-n-alkylbenzoyloxy-)benzoates. In the latter series all the compounds are measomorphic; in the former one, only 3-cyano compounds with long alkoxy chain, exhibit a small mesomorphic range. All the cya[ngrave]o compouns exhibit very high negative dielectric anisotropies.
Thermoplastic Melt Rheology and Processing (1996)

Presents rheological data on a number of polymers, making use of the master curve approach to determine unified curves for each generic type of polymer. The text offers a step-by-step procedure for developing a speadsheet computer program to obtain accurate thermoplastic rheograms at any tempertature without using sophisticated rheometres. It inclu
Closed Fractures of the Tibial Shaft (1998)

We reviewed the literature to determine the clinical outcomes of the treatment of closed fractures of the tibial shaft with immobilization in a cast, open reduction with internal fixation, or fixation with an intramedullary rod. We reviewed 2372 reports of comparative trials and uncontrolled studies of series of patients published between 1966 and 1993. Nineteen reports, involving six controlled trials and twenty-seven groups of patients, met our inclusion criteria. A structured questionnaire was used to assess the quality of the literature in terms of the experimental design and the method of assessment of outcome. Outcomes from controlled trials were summarized with odds ratios and risk differences, and outcomes from case series were summarized by the medians of the reported results. The studies that were reviewed generally had few subjects and were poorly designed. The comparative trials showed treatment with a cast to be associated with a lower rate of superficial infection than open reduction and internal fixation (mean difference, -5.81 per cent; p = 0.02) and open reduction and internal fixation to be associated with a higher rate of union by twenty weeks than treatment with a cast (mean difference, -18.07 per cent; p = 0.008). There were no other significant associations. There were insufficient data for us to evaluate any aspect of functional status, level of pain, or other patient-reported outcomes of any of the methods of treatment. The results of the present review suggest that the data from the published literature are inadequate for decision-making with regard to the treatment of closed fractures of the tibia.
Next-Generation Data Visualization Tools (1994)

Scientific data visualization has finally come of age as an important and accepted discipline. While scientists have been using computer graphics to visualize experimental data and computational results for at least 30 years, recent improvements in cost/performance of graphics workstations, more readily available software, and the new-found name "scientific data visualization" have solidified the discipline. Many thousands of scientists regularly use visualizations as part of their work. Our thesis is that scientists are forced to work too hard to create these visualizations, but that the evolving set of visualization tools can greatly reduce the requisite effort. Further, these tools, and those of the next generation, will open significant new ways to understand increasingly complex and large datasets. Principal causes for this will be the increased interactivity that the tools will naturally offer and the need for designs based on careful consideration of scientific and engineering analysis requirements.
Improved Synthesis of Dialkylaminopyrrolines (2003)

Abstract The literature synthesis of 5-dialkylamino-3,4-dihydro-2H-pyrroles from 5-methoxy-3,4-dihydro-2H-pyrrole has been much improved. In initial assays, the pyrrolinium salts obtained on alkylation of the dibutylaminoamidine are excellent “naked halide” catalysts.
Molecular cloning and expression of ribosome releasing factor (1989)

Ribosome releasing factor (RRF) is responsible for the release of ribosomes from messenger RNA at the termination of Escherichia coli protein biosynthesis (Hirashima, A., and Kaji, A. (1972) Biochemistry 11, 4037-4044). RRF has been partially analyzed by Edman degradation to obtain its amino acid sequence. Based on this analysis, a 47-nucleotide probe was synthesized and used to screen clones from the Clarke and Carbon Gene Bank which carry sequences within the 0-10 min region of the E. coli gene map. The entire RRF cistron was detected on the plasmid pLC6-32. The DNA sequence of RRF was determined, and it was deduced that RRF consists of 185 amino acids with a calculated molecular weight of 20,639. A rho-independent transcriptional termination sequence was found immediately downstream of the RRF cistron. The RRF gene was subcloned into the vector pUC19, and the resulting plasmid was named pRR1. E. coli harboring this plasmid expressed much more RRF than cells containing pUC19, and it was biologically active.
Natural product chemisrty, 143. Convenient synthesis of isoacronycine and some other new acridone derivatives (1991)

Abstract The iodination of 1,3‐dihydroxy‐9‐acridone ( 1 ), 1‐hydroxy‐3‐methoxy‐10‐methyl‐9‐acridone ( 2 ) and 1,3‐dihydroxy‐10‐methyl‐9‐acridone ( 3 ) yields 1,3‐dihydroxy‐2,4‐diiodo‐9‐acridone ( 4 ), 1‐hydroxy‐2‐iodo‐3‐methoxy‐10‐methyl‐9‐acridone ( 5 ) and 1,3‐dihydroxy‐2‐iodo‐10‐methyl‐9‐acridone ( 6 ), respectively. The methylation of 4 and 5 gives 2,4‐diiodo‐1,3‐dimethoxy‐10‐methyl‐9‐acridone ( 7 ) and 2‐iodo‐1,3‐dimethoxy‐10‐methyl‐9‐acridone ( 9 ), respectively. The direct CC coupling of 2‐methyl‐3‐buten‐2‐ol to the compounds 5, 7 and 9 by palladium catalysed Heck condensation method gives three new acridone derivatives 1‐hydroxy‐2‐(3‐hydroxy‐3‐methyl‐1‐butenyl)‐3‐methoxy‐10‐methyl‐9‐acridone ( 10 ), 2,4‐bis(3‐hydroxy‐3‐methyl‐1‐butenyl)‐1,3‐dimethoxy‐10‐methyl‐9‐acridone ( 12 ) and 2‐(3‐hydroxy‐3‐methyl‐1‐butenyl)‐1,3‐dimethoxy‐10‐methyl‐9‐acridone ( 13 ) while compound 6 is converted into isonoracronycine ( 11 ). The methylation of 11 yields isoacronycine ( 14 ).
Multilayer optics with spectral purity layers for the EUV wavelength range (2006)

Reported are the first calculations and experimental results of the deposition of EUV multilayer coatings that actively suppress the reflectance in the VUV wavelength range. In the undesired 100-200 nm band a factor of five reduction was achieved for one single optical element, while only a minor loss of 4.5% reflectance for λ = 13.5 nm, the operating wavelength of EUVL, was found.
Inducer-responsive expression of the cloned human interferon<i>β</i><sub>1</sub>gene introduced into cultured mouse cells (1982)

A hybrid plasmid was constructed from pSV2-Ecogpt (Mulligan and Berg, 1981) and the cloned 1.8 kilobase chromosomal DNA segment which contains the human interferon (HIFN-beta 1) gene and its flanking sequences. Cultured mouse FM3A cells were transfected by the hybrid plasmid and several Ecogpt+ clones were selected. Southern blot analysis of the DNA from these mouse cell clones showed that two of them contained a few copies of the 1.8 kilobase human DNA. Synthesis of mRNA characteristic of the HIFN-beta 1 mRNA increased as measured by RNA blot analysis when those clones were treated with Newcastle disease virus or with poly(I):poly(C). In addition, the induced mouse cell clones gave rise to the synthesis of human IFN-beta 1. These results suggest the presence of a unique nucleotide sequence in the 1.8 kilobase DNA which is sufficient for the inducer-responsive expression of the human IFN-beta 1 gene.
Pediatric intraosseous infusion. (1990)

Venous access in the infant and child is always challenging. The hypotensive child who is deteriorating needs rapid volume expansion and medications. Vascular collapse and previous venous cut-downs can preclude easy cannulation of vessels. Intraosseous infusion of fluids and drugs can be readily performed. The technique is easily mastered and there are few complications.
The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury (2004)

As a non-toxic endogenous antioxidant, the semi-essential amino acid taurine is a potential attenuator of oxidative damage such as that produced by ischaemia-reperfusion injury. Ischaemia-reperfusion injury is a well established if paradoxical phenomenon whereby ischaemic tissue, doomed to necrosis if it is not reperfused, is actually further damaged by oxidative attack when perfusion is restored. This paper is a review of the literature concerning therapeutic strategies in ischaemia-reperfusion injury, including non-pharmacological and pharmacological interventions. There is consistent experimental evidence of an important role of taurine in ischaemia-reperfusion injury, with a clinical role emerging in human trials of taurine administered prior to coronary artery bypass grafting and heart valve surgery.
Enhancing the Brightness Capability of Color-TV Receivers Through the Use of a Spectrally Selective Tinted Glass (1969)

An ideal picture tube for color TV would have three efficient phosphors with almost spectrally pure (narrow) bands of emission on a faceplate which transmits only at the same wave lengths and is opaque at other wave lengths. This poses an interesting physics problem, for how do you make a narrow‐band filter which works simultaneously in three different spectral regions? Working with practical phosphors and available filters, it is interesting to determine what can presently be achieved. A development program, starting out with the well‐known didymium glass, led to the present composition. Measurements have been made to determine the characteristics of a 3% neodymium doped glass having some spectral optical properties approximating the specifications. Such a glass would be used to replace the neutral‐density safety glass now used. Data are presented showing its optical properties, and the changes in spectra, brightness, and color coordinates of tricolor picture tubes. It is concluded that there are some demonstrable improvements in color, brightness, and contrast.
The burden of lung cancer in Kentucky. (2003)

Lung cancer incidence and mortality rates in Kentucky greatly surpass those of other states and the nation as a whole. Not only is this one of the most common cancers, with 3800 newly diagnosed cases per year in the Commonwealth, it is also one of the most fatal. And, unlike many other types of cancer, it is highly preventable, as about 90% are caused by cigarette smoking. In this paper we present lung cancer rates across different groups and trends of the disease over time. We also discuss comparative statistics related to stage at which lung and other major cancers are diagnosed and their survival patterns. Smoking data from the Behavioral Risk Factor Surveillance System are presented and compared across different states in relation to lung cancer occurrence. Finally, both lung cancer and smoking trends within Kentucky are compared, showing how both are substantially higher in the Appalachian region of the state.