gebhart/patrepeval huggingface dataset:
Enhanced Tonic GABA Current in Normotopic and Hilar Ectopic Dentate Granule Cells After Pilocarpine-Induced Status Epilepticus (2009)

In temporal lobe epilepsy, loss of inhibitory neurons and circuit changes in the dentate gyrus promote hyperexcitability. This hyperexcitability is compensated to the point that dentate granule cells exhibit normal or even subnormal excitability under some conditions. This study explored the possibility that compensation involves enhanced tonic GABA inhibition. Whole cell patch-clamp recordings were made from normotopic granule cells in hippocampal slices from control rats and from both normotopic and hilar ectopic granule cells in slices from rats subjected to pilocarpine-induced status epilepticus. After status epilepticus, tonic GABA current was an order of magnitude greater than control in normotopic granule cells and was significantly greater in hilar ectopic than in normotopic granule cells. These differences could be observed whether or not the extracellular GABA concentration was increased by adding GABA to the superfusion medium or blocking plasma membrane transport. The enhanced tonic GABA current had both action potential-dependent and action potential-independent components. Pharmacological studies suggested that the small tonic GABA current of granule cells in control rats was mediated largely by high-affinity alpha(4)beta(x)delta GABA(A) receptors but that the much larger current recorded after status epilepticus was mediated largely by the lower-affinity alpha(5)beta(x)gamma(2) GABA(A) receptors. A large alpha(5)beta(x)gamma(2)-mediated tonic current could be recorded from controls only when the extracellular GABA concentration was increased. Status epilepticus seemed not to impair the control of extracellular GABA concentration by plasma membrane transport substantially. Upregulated tonic GABA inhibition may account for the unexpectedly modest excitability of the dentate gyrus in epileptic brain.
Co-clustering as multilinear decomposition with sparse latent factors (2011)

The K-means clustering problem seeks to partition the columns of a data matrix in subsets, such that columns in the same subset are 'close' to each other. The co-clustering problem seeks to simultaneously partition the rows and columns of a matrix to produce 'coherent' groups called co-clusters. Co-clustering has recently found numerous applications in diverse areas. The concept readily generalizes to higher-way data sets (e.g., adding a temporal dimension). Starting from K-means, we show how co-clustering can be formulated as constrained multilinear decomposition with sparse latent factors. In the case of three- and higher-way data, this corresponds to a PARAFAC decomposition with sparse latent factors. This is important, for PARAFAC is unique under mild conditions and sparsity further improves identifiability. This allows us to uniquely unravel a large number of possibly overlapping co-clusters that are hidden in the data. Interestingly, the imposition of latent sparsity pays a collateral dividend: as one increases the number of fitted co-clusters, new co-clusters are added without affecting those previously extracted. An important corollary is that co-clusters can be extracted incrementally; this implies that the algorithm scales well for large datasets. We demonstrate the validity of our approach using the ENRON corpus, as well as synthetic data.
cDNA Cloning and Characterization of Geotrichum candidum Lipase II (1990)

Geotrichum candidum produces two extracellular Upases, I and II. A lipase II cDNA clone was isolated from a cDNA library by colony hybridization using the 32P-labeled fragment of lipase I cDNA isolated previously. The nucleotide sequence of lipase II cDNA determined by the dideoxy chain terminating method includes the N- and C-terminal ami no acid sequences of lipase II, and the overall amino acid composition deduced from the cDNA coincides with that deduced on amino acid analysis of this protein. The cloned lipase II cDNA codes a protein of 544 amino acids and a part of the signal sequence of 13 amino acids. The peptide chain lengths of Upases I and II are the same, their overall identity being 84%. Furthermore, four Cys residues are completely conserved, which may participate in the formation of disulfide bridges. A homology search indicated that the G. candidum Upases and Candida cylindracea lipase are homologous enzymes and that they are members of the family.
The Giotto magnetometer experiment (1987)

The Giotto magnetometer experiment employs a low-mass (1.357 kg), low-power (818 mW) instrument in a dual magnetometer configuration using flux gate sensors of the ring core type. It has provided accurate vector magnetic field measurements on its way to and near Comet Halley, working flawlessly from switch-on on 22 August 1985 to the formal end of the mission on 15 March 1986.
Pairing of Cooper Pairs in a Fully Frustrated Josephson-Junction Chain (2002)

We study a one-dimensional Josephson-junction chain embedded in a magnetic field. We show that, when the magnetic flux per elementary loop equals half the superconducting flux quantum phi0 = h/2e, a local Z2 symmetry arises. This symmetry is responsible for a nematic Luttinger liquid state associated with bound states of Cooper pairs. We analyze the phase diagram and discuss some experimental possibilities to observe this exotic phase.
Markov chain monte carlo simulations and their statistical analysis: with web-based fortran code (2004)

Sampling, Statistics and Computer Code Error Analysis for Independent Random Variables Markov Chain Monte Carlo Error Analysis for Markov Chain Data Advanced Monte Carlo Parallel Computing Conclusions, History and Outlook.
Engineering of Phenylacetaldehyde Reductase for Efficient Substrate Conversion in Concentrated 2-Propanol (2005)

Phenylacetaldehyde reductase (PAR) is suitable for the conversion of various aryl ketones and 2-alkanones to corresponding chiral alcohols. 2-Propanol acts as a substrate solvent and hydrogen donor of coupled cofactor regeneration during the conversion of substrates catalyzed by PAR. To improve the conversion efficiency in high concentrations of substrate and 2-propanol, selection of a PAR mutant library and the subsequent rearrangement of mutations were attempted. With only a single selection round and following the manual combination of advantageous mutations, PAR was successfully adapted for the conversion of high concentrations of substrate with concentrated 2-propanol. This method will be widely applicable for the engineering of enzymes potentially valuable for industry.
Progressive Significance Map and Its Application to Error-Resilient Image Transmission (2012)

Set partition coding (SPC) has shown tremendous success in image compression. Despite its popularity, the lack of error resilience remains a significant challenge to the transmission of images in error-prone environments. In this paper, we propose a novel data representation called the progressive significance map (prog-sig-map) for error-resilient SPC. It structures the significance map (sig-map) into two parts: a high-level summation sig-map and a low-level complementary sig-map (comp-sig-map). Such a structured representation of the sig-map allows us to improve its error-resilient property at the price of only a slight sacrifice in compression efficiency. For example, we have found that a fixed-length coding of the comp-sig-map in the prog-sig-map renders 64% of the coded bitstream insensitive to bit errors, compared with 40% with that of the conventional sig-map. Simulation results have shown that the prog-sig-map can achieve highly competitive rate-distortion performance for binary symmetric channels while maintaining low computational complexity. Moreover, we note that prog-sig-map is complementary to existing independent packetization and channel-coding-based error-resilient approaches and readily lends itself to other source coding applications such as distributed video coding.
[Role of Chlamydia trachomatis in tubal pathology (acute salpingitis and tubal sterility). Microbiological study of 175 samples of peritoneal fluid]. (1989)

The study was carried out on 175 patients who underwent laparoscopy together with search for chlamydia in the peritoneal fluid when they were having investigations for sterility or for pelvic pain. These patients are classified into three groups according to the clinical and laparoscopic features: 50 cases of acute salpingitis. 104 cases of tubal sterility and 21 control cases who were normal on laparoscopy. The mean age was 25.7 years for acute salpingitis and 30.4 years for tubal sterility. The purpose of this study was to work out the role played by chlamydia trachomatis in tubal phatology and two techniques were used at the same time: The identification of chlamydia trachomatis in 175 samples of peritoneal fluid taken during a laparoscopy; Research for anti-chlamydia antibodies in serum using an indirect micro-immunofluorescent technique. Cell cultures were performed after the peritoneal fluid had been centrifuged. It had been in transport medium 2 SP and frozen. Our technical methods for isolating chlamydia (microplaque culture on Hela lines, incubation in the presence of cycloheximide and research for chlamydial inclusion bodies using direct immunofluorescence with monoclonal antibodies and 2 successive passages of the cells) have allowed us to confirm that chlamydia was present in 44% of cases of acute salpingitis and in 37% of cases of tubal sterility. The search for anti-chlamydial antibodies in the serum in indirect immunofluorescence with a single antigen (of L2 serotype) gave positive results which were comparable to those in other studies, i.e. 50% of positive serological results in acute salpingitis and 63% in tubal sterility.(ABSTRACT TRUNCATED AT 250 WORDS)
Fiber optic waveguides for time-of-flight optical spectrometry (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFiber optic waveguides for time-of-flight optical spectrometryW. B. Whitten and H. H. RossCite this: Anal. Chem. 1979, 51, 3, 417–419Publication Date (Print):March 1, 1979Publication History Published online1 May 2002Published inissue 1 March 1979https://pubs.acs.org/doi/10.1021/ac50039a022https://doi.org/10.1021/ac50039a022research-articleACS PublicationsRequest reuse permissionsArticle Views204Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Application of Lasers in Ophthalmology and Vision Research (1979)

The potential use of dynamic speckles in accommodation or refractive measurements of the eye are discussed. The advantageous application of holographic techniques to eye research and some important results obtained are described. Studies of the modulation sensitivity function of the human visual pathway for both normal and abnormal vision are described which use laser interference, and its possible use in clinical ophthalmology is discussed.
Designing sound for a pervasive mobile game (2005)

We examine the role of sound design in pervasive mobile games. As a case study, we present the sound design and evaluation of a working prototype game called The Songs of North. A play-test with 19 players was conducted over a two-week period. The results imply that using sound information can facilitate physical movement as a main game mechanic. However, using sound to convey information is still an unfamiliar game mechanic to many sighted players. The research highlights the importance of social playability in the sound design of mobile games. Also, some insights on the role of sound in producing immersive gaming experiences are discussed.
Helicopter Structural Life Modeling: Flight Regime and Gross Weight Estimation (2007)

Accurate usage information collected by Health and Usage Monitoring Systems (HUMS) coupled with improved structural fatigue life calculation methodologies promise to reduce helicopter operational and support costs while maintaining current flight safety levels. Current fatigue life calculations assume worst-case flight profiles in determining component life. This approach may be outdated or not reflective of actual aircraft usage. On a small business innovative research (SBIR) contract the Intelligent Automation Corporation (IAC) has developed processing to include a low cost regime recognition and aircraft gross weight estimation capability as an extension to the US Army’s Vibration Management Enhancement Program (VMEP). IAC’s approach relies on multi-sensor data fusion technology and flight parameters collected by VMEP to provide an accurate flight regime calculation. Recording time in particular flight regimes has the potential of extending aircraft component life without changing proven lifing models. The regime recognition system has been implemented with the current release of IAC’s VMEP systems. Presented here are the methodology, development and visualization tools developed on the SBIR as well as results for using the system on AH-64 aircraft in follow-on work.
Relationship between biopharmaceutical immunogenicity of epoetin alfa and pure red cell aplasia (2003)

(2003). Relationship between biopharmaceutical immunogenicity of epoetin alfa and pure red cell aplasia. Current Medical Research and Opinion: Vol. 19, No. 5, pp. 433-434.
A low-cost gripper for an apple picking robot (2004)

A special gripper has been designed to pick apples from trees in an apple orchard. It is a low cost gripper with highly capability to pick an apple without scratching its skin. The gripper has been designed in accordance to the apple orchard environment and robot specification. Furthermore, the experiments show that the gripper can complete all tasks properly. The gripper was mounted on a manipulator and tested in an indoor laboratory environment. Experimental results show that the gripper could successfully pick apples.
Scalable Neural Network Compression and Pruning Using Hard Clustering and L1 Regularization (2018)

We propose a simple and easy to implement neural network compression algorithm that achieves results competitive with more complicated state-of-the-art methods. The key idea is to modify the original optimization problem by adding K independent Gaussian priors (corresponding to the k-means objective) over the network parameters to achieve parameter quantization, as well as an L1 penalty to achieve pruning. Unlike many existing quantization-based methods, our method uses hard clustering assignments of network parameters, which adds minimal change or overhead to standard network training. We also demonstrate experimentally that tying neural network parameters provides less gain in generalization performance than changing network architecture and connectivity patterns entirely.
k-Nearest Neighbour Classifiers (2007)

Abstract. Perhaps the most straightforward classifier in the arsenal or machine learning techniques is the Nearest Neighbour Classifier – classification is achieved by identifying the nearest neighbours to a query example and using those neighbours to determine the class of the query. This approach to classification is of particular importance today because issues of poor run-time performance is not such a problem these days with the computational power that is available. This paper presents an overview of techniques for Nearest Neighbour classification focusing on; mechanisms for assessing similarity (distance), computational issues in identifying nearest neighbours and mechanisms for reducing the dimension of the data. 1
Reed muller-codes with run length properties (2005)

There are many known approaches for improving the run length properties of block codes and convolutional codes and Turbo-Codes without increasing overall redundancy [I]-[5]. In this paper we present some new Transcontrol Codes constructed from Reed Muller Codes using ideas, which where first presented in [4]. In contrast to [5], the constructions are not based on computerized search. There are rather systematic and could be applied for any binary RM codes of nay order.
Multiple Bad Data Detectability and Identifiability: A Geometric Approach (1986)

A method for detecting and identifying multiple bad data in electric power networks is developed by providing a geometric interpretation of the familiar normalized residuals test for single bad data. This generalized multiple bad data test amounts to determining whether the residual vector lies in a subspace determined by the suspect measurements and whether any portions of that subspace are orthogonal to the residual vector. These tests can be performed efficiently using appropriate projection matrices. Thne notion of critical measurement (removal renders the network unobservable) is extended to critical k-tuples of measurements to determine which bad data hypotheses are actually testable. For example, gross errors in critical measurements are not detectable, and gross errors in a critical pair of measurements are detectable but not identifiable. More generally, k-2 gross errors in a critical k-tuple of measurements are identifiable while k or k-l gross errors are detectable but not identifiable. In essence, the set of testable hypotheses is determined by the geometry of the space spanned by all possible residual vectors. A procedure for selecting and pruning a suspect set of measurements is described. Examples for the IEEE 14 bus network are provided.
Rescue of Erythropoietin-Deficient Mice From Anemia by Complementation with BAC Transgene. (2009)

Abstract Abstract 3614 Poster Board III-550 To maintain tissue oxygen homeostasis, erythropoietin (Epo) regulates the erythropoiesis. During embryonic development Epo is produced in the liver, but after birth and throughout adulthood Epo is produced and secreted from the kidney and support definitive erythropoiesis in the bone marrow. Anemia or hypoxic stress provokes transcription of the Epo gene and the mechanisms how the Epo gene expression is activated in a tissue-specific and hypoxia-inducible manner are one of the research topics of the molecular biology or gene regulation study. Since Epo-null mice die in utero of definitive erythropoiesis failure in the fetal liver, physiological significance of the Epo production for the adult erythropoiesis remains to be clarified. We have found that transgenic reporter gene expression driven by a BAC clone containing 180-kb mouse Epo gene locus recapitulates the Epo gene expression in the liver and kidney. To examine whether the Epo gene transcriptional activity within the 180-kb BAC is sufficient to recapitulate physiological Epo production, we attempted to rescue Epo-null mice from embryonic lethality with a BAC transgene harboring a floxed allele of the Epo gene. We found that transgene-derived Epo recovered the erythropoiesis in the fetal liver of Epo-null mice and Epo-null mice with the BAC transgene were born showing a Mendelian ratio. The rescued mice showed no hematological abnormality and were fertile. In the rescued mice bleeding anemia transiently increased plasma Epo level and after recovery from anemia plasma Epo level declined similarly to wild-type mice. In an RT-PCR analysis Epo production in the liver and kidney of the rescued mice was practically equivalent to that in the wild-type counterpart, while other tissues produced only marginal amount of Epo. These results thus demonstrate that the BAC transgene contains the Epo gene regulatory domain region sufficient to fully recapitulate the endogenous Epo gene expression and to compensate for the Epo-deficiency. We also found that the Epo gene deletion from the BAC transgene by general deletor-Cre transgene provoked the Epo-null phenotype, demonstrating that conditional inactivation of the Epo gene is attained in the BAC-rescued mice. The latter system will be a precious tool to investigate adult stage-specific roles of Epo. Disclosures: Yamamoto: Chugai Pharmaceutical, Co., Ltd. : Research Funding.
Podoplanin is a Highly Sensitive and Specific Marker to Distinguish Primary Skin Adnexal Carcinomas From Adenocarcinomas Metastatic to Skin (2007)

Distinction of primary skin adnexal carcinomas from cutaneous metastasis of adenocarcinomas is challenging. In this study, we evaluated podoplanin immunoreactivity in a series of primary skin adnexal tumors and adenocarcinomas metastatic to skin using a D2-40 antibody. The initial test series were composed of a total of 93 cases including 32 primary skin adnexal carcinomas, 46 benign primary adnexal tumors, and 15 cutaneous metastatic adenocarcinomas. We found that variable D2-40 reactivity was seen in all of the primary cutaneous carcinomas including sebaceous carcinomas (10/10), squamous cell carcinomas (10/10), porocarcinomas (4/4), trichilemmal carcinomas (4/4), skin adnexal carcinomas not otherwise specified (4/4), and in the majority of benign skin adnexal tumors. In contrast, no podoplanin immunoreactivity was seen in any of the 15 (0/15) cutaneous metastases. To confirm the initial findings and to further explore the utility of podoplanin reactivity in the distinction of these tumors, we also examined a test set of 35 unknown cases, including 21 adenocarcinomas metastatic to skin and 14 primary adnexal tumors, in a blinded fashion. In this test set of cases, podoplanin was negative in 22 cases and positive in 13 cases. Of the 22 podoplanin negative cases, 20 were proven to be metastatic adenocarcinoma. Of the 13 D2-40 positive cases, 12 were proven to be primary adnexal tumors. Our results suggest that podoplanin can be a useful tool to distinguish primary skin adnexal carcinomas form adenocarcinomas metastatic to skin with high sensitivity (94.5%) and specificity (97.2%).