gebhart/patrepeval huggingface dataset:
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control (2007)

The Hippo pathway plays a key role in organ size control by regulating cell proliferation and apoptosis in Drosophila. Although recent genetic studies have shown that the Hippo pathway is regulated by the NF2 and Fat tumor suppressors, the physiological regulations of this pathway are unknown. Here we show that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway. Phosphorylation by the Lats tumor suppressor kinase leads to cytoplasmic translocation and inactivation of the YAP oncoprotein. Furthermore, attenuation of this phosphorylation of YAP or Yorkie (Yki), the Drosophila homolog of YAP, potentiates their growth-promoting function in vivo. Moreover, YAP overexpression regulates gene expression in a manner opposite to cell density, and is able to overcome cell contact inhibition. Inhibition of YAP function restores contact inhibition in a human cancer cell line bearing deletion of Salvador (Sav), a Hippo pathway component. Interestingly, we observed that YAP protein is elevated and nuclear localized in some human liver and prostate cancers. Our observations demonstrate that YAP plays a key role in the Hippo pathway to control cell proliferation in response to cell contact.
Optimal trajectory generation for time-to-contact based aerial robotic perching (2018)

Many biological organisms (e.g. insects, birds, and mammals) rely on the perception of an informational variable called time-to-contact (TTC) to control their motion for various tasks such as avoiding obstacles, landing, or interception. TTC, defined as the required time to contact an object if the current velocity is maintained, has been recently leveraged for robot motion control in various tasks. However, most existing robotic applications of TTC simply control the TTC to be constant or constantly decreasing, without fully exploring the applicability for TTC. In this paper, we propose two-stage TTC based strategies and apply them to aerial robotic perching. With the proposed strategies, we can generate reference trajectories for TTC to realize the non-zero contact velocity required by perching, which is impossible for constant or constantly decreasing TTC strategy, but of critical importance for robust perching performance. We conduct simulations to verify the superiority of the proposed strategies in terms of shorter time for perching and satisfying more constraints. Further, with properly designed controllers, we perform experiments on a palm-size quadcopter to track the planned reference trajectories and realize aerial robotic perching. The research presented in this paper can be readily applied to the control of flying robot for perching with visual feedback, and can inspire more alternative forms of TTC based planning and control for robotic applications.
Colles fracture: does the anatomical result affect the final function? (1988)

Thirty patients who had sustained a Colles' fracture at least four years previously were examined functionally and radiographically. Seventeen had a good radiological result and 13 were considered to have malunion. Functionally the displaced group performed significantly worse than the undisplaced group. We conclude that malunion of a Colles' fracture results in a weak, deformed, stiff and probably painful wrist.
A thermalization energy analysis of the threshold voltage shift in amorphous indium gallium zinc oxide thin film transistors under simultaneous negative gate bias and illumination (2014)

It has been previously observed that thin film transistors (TFTs) utilizing an amorphous indium gallium zinc oxide (a-IGZO) semiconducting channel suffer from a threshold voltage shift when subjected to a negative gate bias and light illumination simultaneously. In this work, a thermalization energy analysis has been applied to previously published data on negative bias under illumination stress (NBIS) in a-IGZO TFTs. A barrier to defect conversion of 0.65–0.75 eV is extracted, which is consistent with reported energies of oxygen vacancy migration. The attempt-to-escape frequency is extracted to be 106−107 s−1, which suggests a weak localization of carriers in band tail states over a 20–40 nm distance. Models for the NBIS mechanism based on charge trapping are reviewed and a defect pool model is proposed in which two distinct distributions of defect states exist in the a-IGZO band gap: these are associated with states that are formed as neutrally charged and 2+ charged oxygen vacancies at the time of film formation. In this model, threshold voltage shift is not due to a defect creation process, but to a change in the energy distribution of states in the band gap upon defect migration as this allows a state formed as a neutrally charged vacancy to be converted into one formed as a 2+ charged vacancy and vice versa. Carrier localization close to the defect migration site is necessary for the conversion process to take place, and such defect migration sites are associated with conduction and valence band tail states. Under negative gate bias stressing, the conduction band tail is depleted of carriers, but the bias is insufficient to accumulate holes in the valence band tail states, and so no threshold voltage shift results. It is only under illumination that the quasi Fermi level for holes is sufficiently lowered to allow occupation of valence band tail states. The resulting charge localization then allows a negative threshold voltage shift, but only under conditions of simultaneous negative gate bias and illumination, as observed experimentally as the NBIS effect.
The use of a connective tissue graft for closure over an immediate implant covered with an occlusive membrane (1995)

Complete wound closure over an immediate implant is considered to be a desirable goal. This case report describes for the first time the use of a connective tissue autograft placed under the existing flap margins of an extraction socket to successfully achieve closure over an immediate implant covered with an occlusive membrane. The rationale of the method is described. Healing was uneventful and epithelization of the graft surface from surrounding tissues was achieved. This technique created an increased width of keratinized tissue and avoided the need to disrupt the normal anatomical relationships of the surrounding buccal tissues, in contrast to current techniques. The advantages of the technique, together with factors that may influence healing and predictability, are discussed.
A pipelined VLSI chip architecture for real-time computed tomography of fan-beam data (2003)

Image reconstruction from projection data is very computationally intensive. A novel IC architecture is presented which can be used in a pipeline of identical ICs to reconstruct images from parallel- and fan-beam scanner configurations. The accuracy and the finite word-length effects of fan-beam reconstruction are considered. Software simulations of the architecture designed in a 1 mu m CMOS technology show that a maximum clock speed of 40 MHz is possible under nominal operating conditions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Bioactive bone cement: Effect of the amount of glass-ceramic powder on bone-bonding strength (1998)

We examined the influence of the proportion of glass-ceramic powder in a bioactive bone cement of our formula on the bone-bonding ability of cement. Changes in cement bonding with time also were examined. The bioactive bone cement consisted of MgO-CaO-SiO2-P2O5-CaF2 glass-ceramic powder (AW-GC powder) and bisphenol-alpha-glycidyl methacrylate (Bis-GMA)-based resin. AW-GC powder was added to the cement as 0%, 30%, 50%, 70%, and 80% w/w. Rectangular plates (2 x 10 x 15 mm) of each cement with polished surfaces were implanted into the proximal metaphysis of the tibiae of male rabbits, and the failure load was measured by detaching tests 10 and 25 weeks after implantation. The failure loads of each cement were 0% = 0.03, 30% = 1.52, 50% = 2.67, 70% = 3.56, and 80% = 5.59 kg at 10 weeks, and 0% = 0.05, 30% = 1.68, 50% = 2.77, 70% = 3.80, and 80% = 6.37 kg at 25 weeks. Observation of the cement-bone interface revealed that all bioactive bone cements (30%-80%) formed direct contact with bone whereas intervening fibrous tissue was observed in all specimens of the 0% group. By scanning electron microscopy, all bioactive bone cements (30%-80% groups) showed direct contact with bone at the cement-bone interface. In the 0% group, direct contact with bone at the cement-bone interface was not observed. By electron-probe microanalysis, a Ca-P-rich layer was not detected at the cement-bone interfaces of the 30%-70% bioactive bone cements, but in some samples of the 80% cement specimens a thin Ca-P-rich layer (3 microns thick) was observed at the interface at 10 and 25 weeks after implantation. These results show that all of the bioactive bone cements tested had the ability to bond to bone and to function as bioactive composites of ceramics and polymers.
Q-FANSTM for general aviation aircraft (1973)

Continued growth of general aviation over the next 10 to 15 years is dependent on continuing improvement in aircraft safety, utility, performance and cost. Moreover, these advanced aircraft will need to conform to expected government regulations controlling propulsion system emissions and noise levels. An attractive compact low noise propulsor concept, the Q-FANTM when matched to piston, rotary combustion, or gas turbine engines opens up the exciting prospect of new, cleaner airframe designs for the next generation of general aviation aircraft which will provide these improvements and meet the expected noise and pollution restriction of the 1980 time period. New Q-FAN methodology which was derived to predict Q-FAN noise, weight and cost is presented. Based on this methodology Q-FAN propulsion system performance, weight, noise, and cost trends are discussed. Then the impact of this propulsion system type on the complete aircraft is investigated for several representative aircraft size categories. Finally, example conceptual designs for Q-FAN/engine integration and aircraft installations are presented.
Role of Coexpression of IL-2 and Herpes Simplex Virus Proteins in Recombinant Vaccinia Virus Vectors on Levels of Induced Immunity (1990)

Vaccinia virus recombinants co-expressing the genes for IL-2 and HSV-1 gC or gD were used to study the potential adjuvant effects of IL-2 on immunity to HSV-1. In addition, constructs were produced which, while expressing IL-2, encoded for reduced levels of HSV-1 gC. Studies with mice revealed that gC and gD could stimulate HSV-1 immunity as measured by neutralizing antibody (NA), lymphoproliferation and viral clearance. IL-2 enhancement of NA and lymphoproliferation was observed only in those groups of mice immunized with the sub-optimal gC construct which co-expressed IL-2. In no instance did the presence of IL-2 augment the ability of mice to clear an epithelial challenge of HSV-1.
Construction and biological activities of human tPA eukaryotic expression plasmid. (2004)

The present study has laid a foundation for further animal experiment in treating thrombus in transplanted organ by tPA gene transfection.
A non-coherent tracking scheme for the RAKE receiver that can cope with unresolvable multipath (2003)

A novel non-coherent tracking technique for the RAKE receiver is introduced that has a good tracking performance even if multipaths cannot be resolved. Multiple chip-spaced correlators are used on unresolvable multipaths to provide estimates with uncorrelated noise. It is shown that the proposed tracker finds the pseudonoise code timing that maximizes the output of the maximal ratio combiner. The new tracking technique is easy to implement and does not require significantly more computations than conventional non-coherent time tracking techniques. The superior performance of the new tracking loop over conventional early-late time estimators in frequency-selective fading channels is demonstrated by means of computer simulations.
<i>In vitro</i>evidence supporting two mechanisms of action for the anion transport inhibitor L-644,711 in cerebral ischaemia (1992)

L-644,711 is a novel anion channel inhibitor which has previously been shown to decrease brain injury in two related rabbit models of cerebral ischaemia. We hypothesize two mechanisms of action of L-644,711 for its salutary effects on cerebral ischaemia: inhibition of neutrophil function and prevention of excitotoxin release from astrocytes. We present in vitro evidence supporting these two mechanisms of action. L-644,711 demonstrated a dose dependent inhibition of fMLP-induced neutrophil aggregation and superoxide anion release. In addition, L-644,711 demonstrated a dose dependent inhibition of glutamate release from swollen astrocytes in primary culture. We conclude that L-644,711 may prevent brain injury in cerebral ischaemia by inhibiting neutrophil function and preventing release of glutamate from swollen astrocytes.
Symmetrization of the Crystal Lattice of MAPbI<sub>3</sub> Boosts the Performance and Stability of Metal–Perovskite Photodiodes (2017)

Semiconducting lead triiodide perovskites (APbI<sub>3</sub> ) have shown remarkable performance in applications including photovoltaics and electroluminescence. Despite many theoretical possibilities for A<sup>+</sup> in APbI<sub>3</sub> , the current experimental knowledge is largely limited to two of these materials: methylammonium (MA<sup>+</sup> ) and formamidinium (FA<sup>+</sup> ) lead triiodides, neither of which adopts the ideal, cubic perovskite structure at room temperature. Here, a volume-based criterion is proposed for cubic APbI<sub>3</sub> to be stable, and two perovskite materials MA<sub>1-</sub><sub>x</sub> EA<sub>x</sub> PbI<sub>3</sub> (MEPI, EA<sup>+</sup> = ethylammonium) and MA<sub>1-</sub><sub>y</sub> DMA<sub>y</sub> PbI<sub>3</sub> (MDPI, DMA<sup>+</sup> = dimethylammonium) are introduced. Powder and single-crystal X-ray diffraction (XRD) results reveal that MEPI and MDPI are solid solutions possessing the cubic perovskite structure, and the EA<sup>+</sup> and DMA<sup>+</sup> cations play similar roles in the symmetrization of the crystal lattice of MAPbI<sub>3</sub> . Single crystals of MEPI and MDPI are grown and made into plates of a range of thicknesses, and then into metal-perovskite photodiodes. These devices exhibit tripled diffusion lengths and about tenfold enhancement in stability against moisture, both relative to the current benchmark MAPbI<sub>3</sub> . In this study, the systematic approach to materials design and device fabrication greatly expands the candidate pool of perovskite semiconductors, and paves the way for high-performance, single-crystal perovskite devices including solar cells and light emitters.
The effects of low molecular weight chitosans on the characteristics of kimchi during fermentation (1995)

This study was conducted to investigate the preservative effect of low molecular weight chitosans on kimchi(2% salt concentration) during fermentation at . The pH and total acidity of control kimchi were lower and higher, respectively than those of kimchi samples containing chitosan. Reducing sugar content tended to be lower in control kimchi than in kimchi samples containing chitosan until 6 days of fermentation. Malic acid content was lower in control kimchi than in kimchi samples containing chitosan until 4 days of fermentation. Succinic acid content was higher in control kimchi than in kimchi samples containing chitosan at the 2 days of fermentation. Content of lactic and acetic acid also was higher in control kimchi than in kimchi samples containing chitosan at the 4 days of fermentation. The number of total microorganisms and those of microorganisms of Leuconostoc genus and Lactobacillus plantarum were higher in control kimchi than in kimchi samples containing chitosan. The number of microorganisms of Leuconostoc genus was lower in kimchi samples containing chitosan with the lower molecular weight chitosan than those with the higher molecular weight chitosan. Intensity of sensory sour taste and staled flavor were higher in control kimchi than in kimchi samples containing chitosan. There was not much difference in sensory firmness among kimchi samples, but control kimchi was evaluated slightly weaker than kimchi samples containing chitosan. Off-flavor was evaluated as weak in all the kimchi samples.
An Acoustic Analysis of Chinese and English Vowels (2011)

This study compares the articulation of two pairs of similar vowels in Mandarin Chinese in Taiwan and American English. Four Taiwanese learners and four native speakers of American English were recruited to produce five vowels for each language. Acoustic vowel qualities of formant one (F1) and formant two (F2 ) values were measured and analyzed. Results show that Chinese English and American English are different in vowel height and frontness. Pedagogical implications are provided for EFL teachers to help Chinese learners improve their pronunciation.
A Selective Impairment of the IL-2 System in Lymphocytes of Patients with Glioblastomas: Increased Level of Soluble IL-2R and Reduced Protein Tyrosine Phosphorylation (1997)

The occurrence of brain tumors is associated with broad suppression of the immune system function; however, the mechanisms involved in this impairment are not fully characterized. In this study, we have examined mechanisms involved in diminished T lymphocyte reactivity in patients with glioblastomas as compared to patients with other types of brain tumors. We found that the proliferative response of T lymphocytes stimulated with phytohemagglutinin or anti-CD3 was significantly reduced in these patients as compared to patients with meningiomas, oligodendrogliomas and healthy individuals. Stimulated T cells appear to express lower levels of the alpha-subunit (p55) of the IL-2 receptor (IL-2R), and increased levels of soluble IL-2R in cell supernatants, whereas no significant differences were observed in the level of the beta (p75)- or gamma-subunits. In addition, we found that competent T cells of glioblastoma patients exhibit lower levels of tyrosine phosphorylation in response to IL-2 as compared with cells of healthy donors. The decrease in the levels of IL-2 and its receptor was selective since no significant changes were observed in the secretion of other Th1- and Th2-derived cytokines (IFN-gamma and IL-4) and the expression of their respective receptors. These results indicate that the diminished response of T cells obtained from patients with glioblastomas may be due to a selective defect in the production of IL-2 and in the expression of functional IL-2R due to a decreased expression of the membranal IL-2R alpha and to lower levels of tyrosine phosphorylation in response to IL-2.
Material characterization and <i>in vivo</i> behavior of silicon substituted α‐tricalcium phosphate cement (2005)

The possibility and biological effects of substituting silicon in alpha-tricalcium phosphate (alpha-TCP) by way of solid-state reaction have been evaluated. alpha-TCP powders with varying substitution amounts (1 and 5 mol % Ca2SiO4) were synthesized by reacting mixtures of CaCO3, Ca2P2O7, and SiO2, at a rate of 4 degrees C(min)(-1) to 1100 degrees C, left to dwell for 2 h and then heated to 1325 degrees C at 4 degrees C(min)(-1) and left to dwell for a period of 4 h. The powders were then rapidly quenched in air. Si incorporation could be verified by X-ray diffraction analysis, indicating an increase of the lattice volume with increasing Si content from 4284.1(8) to 4334(1) A3 for pure alpha-TCP and alpha-Si5%TCP, respectively. The hydrolysis of milled alpha-SiTCP powders was monitored by isothermal calorimetry, and the compressive strength of set cements was tested. The results showed changes in speed and amount of heat released during reactivity tests and a decrease in mechanical strength (60, 50, and 5 MPa) with increasing Si content. In vitro bioactivity of the set cements after soaking in simulated body fluid for 4 weeks was also tested. The formation of a bonelike apatite layer on the surface of the set cements could be observed and was thickest for 1%Si (20 microm). These results were in good agreement with the in vivo studies performed, which showed strong evidence that the cement containing 1% silicon doped alpha-TCP enhanced mesenchymal cell differentiation and increased osteoblast activity compared with alpha-TCP.
Reduced Pressure MOCVD of C-Axis Oriented BiSrCaCuO Thin Films (1990)

BiSrCaCuO thin films were deposited on MgO(100) single crystal substrates by metalorganic chemical vapor deposition at 500°C and 2 Torr using fluorinated β-diketonate complexes of Sr, Ca and Cu and triphenylbismuth. An inverted vertical reaction chamber allowed uniform film growth over large areas (7.7 cm diameter). The as-deposited films were amorphous mixtures of oxides and fluorides and a two step anealing protocol (750°C+850–870°C) was developed which gives c -axis oriented films of Bi 2 Sr 2 Ca 1 Cu 2 O x . The post-annealed films showed onsets in the resistive transition of 110 K and zero resistivity was achieved by 83 K. Critical current densities as high as 1.1×10 4 A/cm 2 were obtained at 25 K.
Making Sense? The Support of Dispersed Asylum Seekers (2009)

Reforms of the system for the accommodation and support needs of asylum seekers entering the United Kingdom (UK) during the twentieth and early twenty‐first centuries have meant that the support of asylum seekers has largely moved away from mainstream social work to dedicated asylum support teams. This article investigates how the workers engaged as ‘asylum support workers’ understand and make sense of their participation in the support of asylum seekers dispersed across the UK. By drawing on qualitative research with asylum support workers, this paper looks at how such workers make sense of their roles and how the ‘support’ of asylum seekers is conceived. The paper concludes that, by working in this political and controversial area of work, workers are constantly finding ways to negotiate their support role within a dominant framework of control.