gebhart/patrepeval huggingface dataset:
Functional domains of the Drosophila melanogaster muscle myosin heavy-chain gene are encoded by alternatively spliced exons. (1989)

The single-copy Drosophila muscle myosin heavy-chain (MHC) gene, located at 36B(2L), has a complex exon structure that produces a diversity of larval and adult muscle MHC isoforms through regulated alternative RNA splicing. Genomic and cDNA sequence analyses revealed that this 21-kilobase MHC gene encodes these MHC isoforms in 19 exons. However, five sets of these exons, encoding portions of the S1 head and the hinge domains of the MHC protein, are tandemly repeated as two, three, four, or five divergent copies, which are individually spliced into RNA transcripts. RNA hybridization studies with exon-specific probes showed that at least 10 of the 480 possible MHC isoforms that could arise by alternative RNA splicing of these exons are expressed as MHC transcripts and that the expression of specific members of alternative exon sets is regulated, both in stage and in muscle-type specificity. This regulated expression of specific exons is of particular interest because the alternatively spliced exon sets encode discrete domains of the MHC protein that likely contribute to the specialized contractile activities of different Drosophila muscle types. The alternative exon structure of the Drosophila MHC gene and the single-copy nature of this gene in the Drosophila genome make possible transgenic experiments to test the physiological functions of specific MHC protein domains and genetic and molecular experiments to investigate the mechanisms that regulate alternative exon splicing of MHC and other muscle gene transcripts.
Steady-State Pharmacokinetic, Safety, and Tolerability Profiles of Quetiapine, Norquetiapine, and Other Quetiapine Metabolites in Pediatric and Adult Patients with Psychotic Disorders (2008)

Pediatric and adult populations demonstrated similar pharmacokinetic, safety, and tolerability profiles for quetiapine administered by dose escalation. The predictability in quetiapine concentration profiles for children aged 10 years to adults suggests that no dosage adjustment may be required when treating patients of these ages.
IN VITRO ANTIOXIDANT ACTIVITY AND THE EFFECT OF METHANOLIC EXTRACTS OF SOME LOCAL PLANTS ON NUTRITIONALLY STRESSED RATS. (2011)

Summary In this study, the in vitro and in vivo antioxidant activities of the methanolic extracts from six locally consumed plants in Nigeria were comparatively evaluated. The study plants include V. amygdalina (bitter leaf); C. rubens (‘ebolo’); A. hybridus (‘tete’); J. tanjorensis (‘hospital too far’, jatropha); G. africana (‘okazi’ ) and T. triangulare (water leaf). Results from the in vitro study indicated that the DPPH radical scavenging activity was highest (p<0.05) in ebolo and water
Building a Machine Learning Model for the SOC, by the Input from the SOC, and Analyzing it for the SOC (2018)

This work demonstrates an ongoing effort to employ and explain machine learning model predictions for classifying alerts in Security Operations Centers (SOC). Our ultimate goal is to reduce analyst workload by automating the process of decision making for investigating alerts using the machine learning model in cases where we can completely trust the model. This way, SOC analysts will be able to focus their time and effort to investigate more complex cases of security alerts. To achieve this goal, we developed a system that shows the prediction for an alert and the prediction explanation to security analysts during their daily workflow of investigating individual security alerts. Another part of our system presents the aggregated model analytics to the managers and stakeholders to help them understand the model and decide, on when to trust the model and let the model make the final decision. Using our prediction explanation visualization, security analysts will be able to classify oncoming alerts more efficiently and gain insight into how a machine learning model generates predictions. Our model performance analysis dashboard helps decision makers analyze the model in signature level granularity and gain more insights about the model.
Water-stable metal–organic frameworks with intrinsic peroxidase-like catalytic activity as a colorimetric biosensing platform (2013)

Two iron(III)-based metal-organic frameworks (MOFs) are found to behave as efficient peroxidase mimics and catalyze the oxidation of different peroxidase substrates by H2O2 accompanied with significant color change in the solution. With these findings, a simple and sensitive colorimetric assay to detect H2O2 and ascorbic acid has been established.
Controlled Traffic Cropping System (1986)

Major tillage energy losses can be avoided by confining all tractor/implement wheels to permanent uncultivated 'roadbeds' in the field, occupying 13% of paddock area. The remaining uncompacted field area, is the 'rootbed' in a controlled traffic crop production system. Further energy savings might occur because the number and intensity of tillage operations can be reduced in the rootbeds. Reduced traffic and perhaps reduced tillage might also have a beneficial effect on soil condition. Two years work at QAC has demonstrated that controlled traffic alone can reduce the energy requirement of heavy tillage by >50% in terms of tractor engine power output. There is also some evidence of a reduction in tillage intensity and improvement in soil conditions. Yield of the first winter cereal crop grown under controlled traffic was reduced by 13%, but the yield of summer crops and of subsequent winter crops has been unaffected.
Hippocampal neuron loss in temporal lobe epilepsy: Correlation with early childhood convulsions (1987)

Hippocampal neuron densities in three areas (H1 zone, end folium, and dentate gyrus) were counted in each of 32 temporal lobectomy excision specimens using the technique of Mouritzen Dam. The association between severe neuronal loss in all three areas and early childhood convulsions that were prolonged and/or lateralized was highly significant. Lesser degrees of neuron loss in H1 and/or end folium were common and were not associated with early childhood convulsions, but were most often found in older patients with a particularly long history of epilepsy.
Perinatal rat lung catalase gene expression: influence of corticosteroid and hyperoxia (1991)

Dexamethasone accelerates the late gestational rise in rat lung catalase activity; neonatal hyperoxia elevates rat lung catalase activity. We studied the regulation of catalase gene expression in these instances. Catalase mRNA/mg DNA increased to gestation day 22 and then fell to the concentration in adult lungs. The rate of transcription of catalase mRNA was higher on gestation day 22 than gestation day 19, whereas the half-life of catalase mRNA (approximately 7 h) was the same on both days. Dexamethasone given 48 and 24 h before expected birth (gestation 22 days) increased catalase mRNA concentration at days 20 and 22 without a change in catalase mRNA stability. Early postnatal hyperoxia (greater than 95% O2, 72 h) elevated catalase mRNA/mg DNA and doubled its half-life without changing its rate of transcription. We conclude the normal late gestational elevation of catalase activity and the increase of activity during prenatal dexamethasone treatment are regulated at the level of gene transcription. By contrast, the elevation of catalase activity during neonatal hyperoxia is mediated posttranscriptionally by increased catalase mRNA stability.
The human genome structure and organization. (2001)

Genetic information of human is encoded in two genomes: nuclear and mitochondrial. Both of them reflect molecular evolution of human starting from the beginning of life (about 4.5 billion years ago) until the origin of Homo sapiens species about 100,000 years ago. From this reason human genome contains some features that are common for different groups of organisms and some features that are unique for Homo sapiens. 3.2 x 10(9) base pairs of human nuclear genome are packed into 23 chromosomes of different size. The smallest chromosome - 21st contains 5 x 10(7) base pairs while the biggest one -1st contains 2.63 x 10(8) base pairs. Despite the fact that the nucleotide sequence of all chromosomes is established, the organisation of nuclear genome put still questions: for example: the exact number of genes encoded by the human genome is still unknown giving estimations from 30 to 150 thousand genes. Coding sequences represent a few percent of human nuclear genome. The majority of the genome is represented by repetitiVe sequences (about 50%) and noncoding unique sequences. This part of the genome is frequently wrongly called "junk DNA". The distribution of genes on chromosomes is irregular, DNA fragments containing low percentage of GC pairs code lower number of genes than the fragments of high percentage of GC pairs.
<title>Optical Pattern Generator Using Excimer Laser</title> (1988)

Reticles (masks on enlarged scale) are needed for optical pattern transfer in the production of integrated semiconductor circuits. In order to meet present requirements for 5X reticles only a direct writing technique is feasible. This means direct exposing of photoresist either with light or an electron beam. Many of todays highly dense reticles require some 10 5 to 10 6 discrete exposures when generated with an optical pattern generator. Optical pattern generators normally use mercury arc lamps to expose positive photoresist, which in turn need 200 milliseconds for each of these discrete exposures, thus requiring to stop the table at every exposure position ("stop and go" mode). This results in running times of several days per reticle. Therefore most reticles are nowadays being manufactured with very expensive e-beam machines. In the early 80's we started the first experiments to expose photoresist with an excimer laser. In order to obtain the maximum gain in speed, the goal was to operate with only one excimer laser pulse per exposure, so that a fast "flash on the fly" operation with an optical pattern generator became true. Equipping a conventional optical pattern generator with an excimer laser as the light source, it has become possible to expose substrates coated with standard photoresist in the "flash on the fly" mode with only 13 nanoseconds per flash. So the thruput could be increased up to 25 times in comparison to a pattern generator equipped with a mercury lamp. A comparison of both operation modes will show that an immense increase of speed is possible, even when a ten years old M3600 pattern generator is used. This system is in function now with very high reliability since more than three years in our IC development line.
IMPROVED 72-HOUR RENAL PRESERVATION WITH PHOSPHATE-BUFFERED SUCROSE (1989)

The result of this study shows that a simple phosphate buffered sucrose solution (PBS) is better than hyperosmolar citrate (HOC) solution in the flush perfusion and hypothermic storage of canine kidneys for 72 hr prior to autotransplantation with immediate contralateral nephrectomy. The peroperative measurement of postreperfusion renal blood flow revealed a significant reduction after 60 min in kidneys preserved with HOC solution. All grafts and animals in the PBS group (5/5) survived with primary renal function compared with one in the HOC group (1/5), which functioned after a period of oliguria. The early serum creatinine and urea levels were significantly lower in the PBS group, with a return to normal range within two weeks. This is reflected in higher inulin clearances and a more rapid recovery of proximal tubular function in the PBS animals, which also demonstrated a more rapid return of loop function and the ability to concentrate urine.
Electromagnetics (2001)

Providing an ideal transition from introductory to advanced concepts, Electromagnetics, Second Edition builds a foundation that allows electrical engineers to confidently proceed with the development of advanced EM studies, research, and applications. This second edition of a popular text continues to offer coverage that spans the entire field, from electrostatics to the integral solutions of Maxwell’s equations. The book provides a firm grounding in the fundamental concepts of electromagnetics and bolsters understanding through the use of classic examples in shielding, transmission lines, waveguides, propagation through various media, radiation, antennas, and scattering. Mathematical appendices present helpful background information in the areas of Fourier transforms, dyadics, and boundary value problems. The second edition adds a new and extensive chapter on integral equation methods with applications to guided waves, antennas, and scattering. Utilizing the engaging style that made the first edition so appealing, this second edition continues to emphasize the most enduring and research-critical electromagnetic principles.
The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response (2010)

MTXGlu remains a potentially useful tool for determining outcomes in patients with JIA being treated with MTX. The genetic predictors of MTXGlu variability may also contribute to a better understanding of the intracellular biotransformation of MTX in these patients.
<i>Herpesvirus cyprini:</i> lethality and oncogenicity (1991)

Abstract. Cyprinid herpesvirus 1 (CHV) or Herpesvirus cyprini was virulent for carp, Cyprinus carpio L., fry following 1 h immersion in water at 20 °C. Cumulative mortality for carp fry was 86–97% in 2‐week‐old common carp, 20% in 4‐week‐old fancy carp, and 0% in both 8‐week‐old common and fancy carp. The virus did not produce mortality in fry of crucian carp, grass carp or other cyprinids. It was also oncogenic in carp, inducing papillomas to the extent of 55% among both common and fancy carp fry. The neoplasms appeared 5–6 months after carp had been exposed to the virus by immersion and recurred at an incidence of 83% in carp 7·5 months post‐desquamation of the tumour. The CHV was reisolated from all moribund fish and from all survivors. It also induced papillomas at an incidence of 13% in adult mirror carp and at 10% in adult fancy carp 5 months after intraperitoneal inoculation of 10 5 TCID 50 ml ‐1 fish. The virus was rcisolated only from the ncoplastic tissue and not from internal organs. The neoplasms were normally located on fin, skin or mandible, at the intraperitoneal inoculation site. Specific fluorescence for CHV antigen was frequently detected in the gills, liver, kidneys and intestine of 2‐week‐old fry from 3 to 21 days following challenge with CHV. It was found in greater concentrations in experimentally induced papillomata on 2‐week‐old carp fry survivors examined 24 weeks after challenge than in naturally occurring neoplasms.
Monitoring procedure for intelligent control: on-line identification of maximum closed-loop log modulus (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMonitoring procedure for intelligent control: on-line identification of maximum closed-loop log modulusRen Chiou Chiang and Cheng Ching YuCite this: Ind. Eng. Chem. Res. 1993, 32, 1, 90–99Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/ie00013a013https://doi.org/10.1021/ie00013a013research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nuclear Localization and Cell Cycle Regulation of a Murine Protein Tyrosine Phosphatase (1994)

MPTP is a murine homolog of the human T-cell protein tyrosine phosphatase (PTPase) and the rat PTP-S enzyme. Enzymatic activity of this ubiquitously expressed protein was demonstrated in immunoprecipitates from NIH 3T3 cells and in recombinant protein overexpressed in bacteria. Expression of beta-galactosidase-MPTP MPTP chimeric proteins in COS1 cells identified a nuclear localization signal at the carboxyl terminus of the MPTP that was sufficient to direct beta-galactosidase as well as a tagged version of the MPTP to the nucleus. Deletion analysis of amino acids within the nuclear targeting signal showed that this sequence does not conform to the bipartite type of nuclear localization signals. Furthermore, it was shown that the steady-state levels of MPTP RNA fluctuate in a cell cycle-specific manner. On the basis of these experiments, we discuss the possible function of MPTP in the cell cycle and other nuclear processes.
Development of polymer blend morphology during compounding in a twin‐screw extruder. Part IV: A new computational model with coalescence (1995)

Abstract In Part II of this series of publications, the first generation model of morphology evolution during polymer blending in a twin‐screw extruder was presented. The model was based on a simplified flow analysis, and an assumption that dispersion occurs via drop fibrillation followed by disintegration. In the present Part IV, several modifications of the model are discussed. (i) The flow analysis was refined by computing the pressure profiles. (ii) The flow paths and strain history of the dispersed droplets within the screw elements are computed directly, which makes it possible to determine the drop susceptibility to deformation and break. (iii) Besides the fibrillation mechanism, a drop‐splitting mechanism for low supercritical capillary numbers is incorporated. (iv) The choice of breakup mechanism is based on micro‐rheological criteria. (v) The coalescence effects are taken into account. (vi) The theoretical model is self‐consistent, without adjustable parameters. The validity of theoretical assumptions was evaluated by comparing the model predictions with the experimental droplet diameters at different positions in the twin‐screw extruder.
[The absence of a relation between apolipoprotein E genotypes and the severity of multiple sclerosis in Mexican patients]. (2010)

Our results do not suggest any association between the presence of the ApoE epsilon-4 allele and the progression of disability in patients with MS in our sample.
The survey of large-scale query classification (2017)

In recent years, a lot of researches have been done on query classification. The paper introduces the recent researches on query classification in detail, mainly including the source of query log, the category systems, the feature extraction methods, classification methods and the evaluation methodology. Then it discusses the issues of large-scale query classification and the solved methods combined with big data analysis systems. The research result shows there still are several problems and challenges, such as lack of authoritative classification system and evaluation methodology, efficiency of the feature extraction method, uncertainty of the performance on large-scale query log and the further query classification on the big data platform, etc.
Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype (2008)

A two-SNP screening test can identify the highest risk heterozygous genotype for type 1 diabetes in a time- and cost-effective manner.
Characterization of the Regulation of CD46 RNA Alternative Splicing (2016)

Here we present a detailed analysis of the alternative splicing regulation of human CD46, which generates different isoforms with distinct functions. CD46 is a ubiquitous membrane protein that protects host cells from complement and plays other roles in immunity, autophagy, and cell adhesion. CD46 deficiency causes an autoimmune disorder, and this protein is also involved in pathogen infection and cancer. Before this study, the mechanisms of CD46 alternative splicing remained unexplored even though dysregulation of this process has been associated with autoimmune diseases. We proved that the 5' splice sites of CD46 cassette exons 7 and 8 encoding extracellular domains are defined by noncanonical mechanisms of base pairing to U1 small nuclear RNA. Next we characterized the regulation of CD46 cassette exon 13, whose inclusion or skipping generates different cytoplasmic tails with distinct functions. Using splicing minigenes, we identified multiple exonic and intronic splicing enhancers and silencers that regulate exon 13 inclusion via trans-acting splicing factors like PTBP1 and TIAL1. Interestingly, a common splicing activator such as SRSF1 appears to repress CD46 exon 13 inclusion. We also report that expression of CD46 mRNA isoforms is further regulated by non-sense-mediated mRNA decay and transcription speed. Finally, we successfully manipulated CD46 exon 13 inclusion using antisense oligonucleotides, opening up opportunities for functional studies of the isoforms as well as for therapeutics for autoimmune diseases. This study provides insight into CD46 alternative splicing regulation with implications for its function in the immune system and for genetic disease.
Bone Marrow Mesenchymal Stem Cells Suppress Lymphocyte Proliferation In Vitro but Fail to Prevent Graft-versus-Host Disease in Mice (2006)

Several reports have suggested that mesenchymal stem cells (MSCs) could exert a potent immunosuppressive effect in vitro, and thus may have a therapeutic potential for T cell-dependent pathologies. We aimed to establish whether MSCs could be used to control graft-vs-host disease (GVHD), a major cause of morbidity and mortality after allogeneic hemopoietic stem cell transplantation. From C57BL/6 and BALB/c mouse bone marrow cells, we purified and expanded MSCs characterized by the lack of expression of CD45 and CD11b molecules, their typical spindle-shaped morphology, together with their ability to differentiate into osteogenic, chondrogenic, and adipogenic cells. These MSCs suppressed alloantigen-induced T cell proliferation in vitro in a dose-dependent manner, independently of their MHC haplotype. However, when MSCs were added to a bone marrow transplant at a MSCs:T cells ratio that provided a strong inhibition of the allogeneic responses in vitro, they yielded no clinical benefit on the incidence or severity of GVHD. The absence of clinical effect was not due to MSC rejection because they still could be detected in grafted animals, but rather to an absence of suppressive effect on donor T cell division in vivo. Thus, in these murine models, experimental data do not support a significant immunosuppressive effect of MSCs in vivo for the treatment of GVHD.