gebhart/patrepeval huggingface dataset:
substituted (S)-Phenylpiperidines and Rigid Congeners as Preferential Dopamine Autoreceptor Antagonists: Synthesis and Structure-Activity Relationships (1994)

A series of (S)-phenylpiperidines in which the substituents on the aromatic ring and nitrogen have been varied has been prepared. They have been evaluated pharmacologically to explore the importance of these substituents for the interaction with central dopamine (DA) receptors. On the basis of biochemical and behavioral data in rats, several of these compounds are characterized as centrally acting DA autoreceptor antagonists. (S)-Phenylpiperidines having an aromatic substituent with a high group dipole moment in the 3-position, i.e., meta with respect to the piperidine ring, and being N-substituted with a propyl group were found to be highly active in vivo on the synthesis and turnover of dopamine. However, they do not induce strong hypoactivity or catalepsy. Interestingly, the most active compounds in vivo were found to display only low affinity for DA D2 and D3 receptors in vitro. In addition, 7-triflate-substituted octahydrobenzo[f]quinolines and 6-triflate-substituted hexahydro-1H-benz[e]indoles have been prepared and pharmacologically evaluated. The trans isomers of these rigid structures were found to display a pharmacological profile similar to that of the flexible phenylpiperidines. The corresponding cis isomers were found to be inactive in vivo.
Speckle suppression in scanning laser display (2008)

The theory of speckle noise in a scanning beam is presented. The general formulas for the calculation of speckle contrast, which apply to any scanning display, are obtained. It is shown that the main requirement for successful speckle suppression in a scanning display is a narrow autocorrelation peak and low sidelobe level in the autocorrelation function of the complex amplitude distribution across a scanning light beam. The simple formulas for speckle contrast for a beam with a narrow autocorrelation function peak were obtained. It was shown that application of a diffractive optical element (DOE) with a Barker code phase shape could use only natural display scanning motion for speckle suppression. DOE with a Barker code phase shape has a small size and may be deposited on the light modulator inside the depth of the focus of the reflected beam area, and therefore, it does not need an additional image plane and complicated relay optics.
Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor (2015)

The oncogenic E5 protein from bovine papillomavirus is a short (44 amino acids long) integral membrane protein that forms homodimers. It activates platelet-derived growth factor receptor (PDGFR) β in a ligand-independent manner by transmembrane helix-helix interactions. The nature of this recognition event remains elusive, as numerous mutations are tolerated in the E5 transmembrane segment, with the exception of one hydrogen-bonding residue. Here, we examined the conformation, stability, and alignment of the E5 protein in fluid lipid membranes of substantially varying bilayer thickness, in both the absence and presence of the PDGFR transmembrane segment. Quantitative synchrotron radiation circular dichroism analysis revealed a very long transmembrane helix for E5 of ∼26 amino acids. Oriented circular dichroism and solid-state (15)N-NMR showed that the alignment and stability of this unusually long segment depend critically on the membrane thickness. When reconstituted alone in exceptionally thick DNPC lipid bilayers, the E5 helix was found to be inserted almost upright. In moderately thick bilayers (DErPC and DEiPC), it started to tilt and became slightly deformed, and finally it became aggregated in conventional DOPC, POPC, and DMPC membranes due to hydrophobic mismatch. On the other hand, when E5 was co-reconstituted with the transmembrane segment of PDGFR, it was able to tolerate even the most pronounced mismatch and was stabilized by binding to the receptor, which has the same hydrophobic length. As E5 is known to activate PDGFR within the thin membranes of the Golgi compartment, we suggest that the intrinsic hydrophobic mismatch of these two interaction partners drives them together. They seem to recognize each other by forming a closely packed bundle of mutually aligned transmembrane helices, which is further stabilized by a specific pair of hydrogen-bonding residues.
Expression and sequence of outer surface protein C among North American isolates of Borrelia burgdorferi (1994)

The expression of outer surface protein C (OspC) was determined for North American Borrelia burgdorferi isolates HB19, DN127c19-2, 25015 and both low and high culture passage B31. A monoclonal antibody detected the presence of OspC protein in only two isolates, while polyclonal antiserum identified this protein in all five isolates. The ospC gene was cloned and sequenced for isolates HB19, DN127c19-2 and 25015, and compared with the published ospC sequences of other Lyme disease spirochetes. Bothe the nucleotide and amino acid sequences were found to vary as much among isolates from the same geographic area as between isolates of different species.
Zircon‐Zirconia Ceramics Prepared from Plasma Dissociated Zircon (1982)

A ceramic consisting of a dispersion of ZrO 2 particles (∼25%) in zircon was prepared by sintering partially leached plasma dissociated zircon. ZrO 2 particles smaller than ∼150 nm were tetragonal inform; larger particles were monoclinic. The large increase in proportions of tetragonal ZrO 2 after sintering may be ascribed partly to a reduction in particle size by reaction to form zircon, and partly to a matrix effect on the tetragonal to monoclinic transformation.
Computational Intelligence in Wireless Sensor Networks: A Survey (2010)

Wireless sensor networks (WSNs) are networks of distributed autonomous devices that can sense or monitor physical or environmental conditions cooperatively. WSNs face many challenges, mainly caused by communication failures, storage and computational constraints and limited power supply. Paradigms of computational intelligence (CI) have been successfully used in recent years to address various challenges such as data aggregation and fusion, energy aware routing, task scheduling, security, optimal deployment and localization. CI provides adaptive mechanisms that exhibit intelligent behavior in complex and dynamic environments like WSNs. CI brings about flexibility, autonomous behavior, and robustness against topology changes, communication failures and scenario changes. However, WSN developers are usually not or not completely aware of the potential CI algorithms offer. On the other side, CI researchers are not familiar with all real problems and subtle requirements of WSNs. This mismatch makes collaboration and development difficult. This paper intends to close this gap and foster collaboration by offering a detailed introduction to WSNs and their properties. An extensive survey of CI applications to various problems in WSNs from various research areas and publication venues is presented in the paper. Besides, a discussion on advantages and disadvantages of CI algorithms over traditional WSN solutions is offered. In addition, a general evaluation of CI algorithms is presented, which will serve as a guide for using CI algorithms for WSNs.
Nematic Liquid Crystals with Polar Ordering Formed from Simple Aromatic Polyester (1996)

In this study, we describe a distinct nematic liquid crystal with polar ordering which is formed from the polar rod-like aromatic copolyester comprising 4-hydroxybenzoic acid and 6-hydroxy-2-naphthoic acid. The polarity in the nematic phase appears along the nematic director as determined by second-harmonic generation (SHG). It was found that SHG activity appears in compounds with a high degree of polymerization. This suggests that the strong dipole-dipole interaction between polar rod-like molecules is the origin of the polar structure.
Gold(I) Complexes with Hydrogen-Bond Supported Heterocyclic Carbenes as Active Catalysts in Reactions of 1,6-Enynes (2008)

Complexes [AuCl{C(NHR)(NHPy-2)}] (Py-2 ) 2-pyridyl; R ) Me, tBu, nBu, iPr, nheptyl) have been prepared in amodular way from [AuCl(CNPy-2)]. The carbene moiety has a hydrogen-bond supported heterocyclic structure similar to the nitrogen heterocyclic carbenes in the solid state, and in CH2Cl2 or acetone solution, which is open in the presence of MeOH. The compounds are good catalysts for the skeletal rearrangement of enynes, and for the methoxycyclization of enynes. In contrast, the complexes [AuCl{C(NHR)(NHPy-4)}] are scarcely active due to the blocking effect of the coordination position required for the catalysis by the nitrogen of the NHPy-4 group.
The BH4 domain of Bcl-XL rescues astrocyte degeneration in amyotrophic lateral sclerosis by modulating intracellular calcium signals (2011)

Collective evidence indicates that motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is non-cell-autonomous and requires the interaction with the neighboring astrocytes. Recently, we reported that a subpopulation of spinal cord astrocytes degenerates in the microenvironment of motor neurons in the hSOD1(G93A) mouse model of ALS. Mechanistic studies in vitro identified a role for the excitatory amino acid glutamate in the gliodegenerative process via the activation of its inositol 1,4,5-triphosphate (IP(3))-generating metabotropic receptor 5 (mGluR5). Since non-physiological formation of IP(3) can prompt IP(3) receptor (IP(3)R)-mediated Ca(2+) release from the intracellular stores and trigger various forms of cell death, here we investigated the intracellular Ca(2+) signaling that occurs downstream of mGluR5 in hSOD1(G93A)-expressing astrocytes. Contrary to wild-type cells, stimulation of mGluR5 causes aberrant and persistent elevations of intracellular Ca(2+) concentrations ([Ca(2+)](i)) in the absence of spontaneous oscillations. The interaction of IP(3)Rs with the anti-apoptotic protein Bcl-X(L) was previously described to prevent cell death by modulating intracellular Ca(2+) signals. In mutant SOD1-expressing astrocytes, we found that the sole BH4 domain of Bcl-X(L), fused to the protein transduction domain of the HIV-1 TAT protein (TAT-BH4), is sufficient to restore sustained Ca(2+) oscillations and cell death resistance. Furthermore, chronic treatment of hSOD1(G93A) mice with the TAT-BH4 peptide reduces focal degeneration of astrocytes, slightly delays the onset of the disease and improves both motor performance and animal lifespan. Our results point at TAT-BH4 as a novel glioprotective agent with a therapeutic potential for ALS.
HPV Vaccine against Anal HPV Infection and Anal Intraepithelial Neoplasia (2011)

Use of the qHPV vaccine reduced the rates of anal intraepithelial neoplasia, including of grade 2 or 3, among men who have sex with men. The vaccine had a favorable safety profile and may help to reduce the risk of anal cancer. (Funded by Merck and the National Institutes of Health; ClinicalTrials.gov number, NCT00090285.).
Deposition and characterisation of ultralow-stress ZnO thin films for application in FBAR-based gravimetric biosensors (2011)

Zinc oxide (ZnO) thin films were deposited at high rates ( > 50 nm min –1 ) using a unique technique known as high target utilisation sputtering (HiTUS). The films obtained possess good crystallographic orientation, low surface roughness, very low stress and excellent piezoelectric properties. We have utilised the films to develop highly sensitive biosensors based on thickness longitudinal mode (TLM) thin film bulk acoustic resonators (FBARs). The FBARs have the fundamental TLM at a frequency near 1.5 GHz and quality factor Q higher than 1,000, which is one of the largest values ever reported for ZnO-based FBARs. Bovine Serum Albumin (BSA) solutions with different concentrations were placed on the top of different sets of identical FBARs and their responses to mass-loading from physically adsorbed protein coatings were investigated. These resonators demonstrated a high sensitivity and thus have a great potential as gravimetric sensors for biomedical applications.
Descriptive sensory analysis of broiler breast fillets marinated in phosphate, salt, and acid solutions (2005)

Sensory attributes of fully aged broiler breast fillets marinated in a 6% NaCl solution containing 2% sodium tripolyphosphate (2P), 2% citric acid (2C), 2% acetic acid (2A), 1% citric acid plus 1% phosphate solution (1C), or 1% acetic acid solution plus 1% phosphate (1A) were studied. A 6% NaCl (6S) solution with no additives was used as control. Oven-cooked samples (177C degrees oven; 75 degrees C internal temperature) were evaluated by a 9-member trained descriptive analysis sensory panel that rated the intensities of 26 different flavor and texture attributes using 15-point line scales. Data were analyzed using general linear model SAS procedures to determine significant differences (P < or = 0.05) in individual sensory attributes due to marinade treatment. All sensory attributes were scored in the low intensity range (1.5 to 5.0). Brothy, vinegar, and residual particles were the only individual attributes rated significantly different (P < or = 0.05) due to treatment. Multivariate analyses indicated that all sensory attributes formed 2 dimensions that explained 57% of variation in the data. The low intensity values for texture attributes indicated possible negative consequences due to phosphates, salt, and acids when used with fully aged fillets.
Intelligent Alcohol Fuel Sensor (1990)

<div class="htmlview paragraph">For the use in flexible fuel vehicles able to operate with mixtures of alcohol fuels and gasoline, an intelligent alcohol sensor has been developed.</div> <div class="htmlview paragraph">Based on the measurement of the dielectric constant, this sensor overcomes the problems with optical measuring principles; these problems are due to sensitivity to different contents of aromatics. To increase the accuracy, a microprocessor evaluates the input signals (dielectric constant and other parameters). Thus, a compensation of misdetection due to impurities can also be achieved. The output characteristic of the sensor can be chosen freely; the output voltage can correspond to the alcohol content as well as to the required correction factor for the injection time.</div>
Architecture and enablers for optimized radio resource usage in heterogeneous wireless access networks: The IEEE 1900.4 Working Group (2009)

Over the past decade or so, the wireless industry has undergone many significant changes. Radio systems have moved toward forming heterogeneous wireless networks: collaborations of multiple radio access networks, which in some cases operate different radio access technologies, such as second- and third-generation cellular RATs, IEEE 802.x wireless standards, and so on. On the other hand, multimode reconfigurable user devices with the ability to choose among various supported RATs have become a reality, and devices and networks with dynamic spectrum access capabilities, allowing real-time sharing of spectrum resource usage among different systems, are expected to be a part of the future radio eco-space. As a result of these changes, there is a need to develop a standard that addresses the requirements and leverages the opportunities posed by such a versatile radio environment. To this end, IEEE 1900.4 aims to standardize the overall system architecture and information exchange between the network and mobile devices, which will allow these elements to optimally choose from available radio resources. In other words, the standard facilitates the distributed dynamic optimization of the usage of spectrum offered by the heterogeneous wireless network, relying on a collaborative information exchange between networks and mobile devices, thereby acting as a common means to improve overall composite capacity and quality of service for the served networks. This article provides a snapshot of IEEE P1900.4 in its current form, covering the scope and purpose of the standard, reference use cases for which the standard is applicable, its system and functional architectures, and finally, the information model for its main interfaces.
AMPA potentiator treatment of cognitive deficits in Alzheimer disease (2007)

Patients treated with LY451395 did not show a statistically significant separation from patients taking placebo on the Alzheimer's Disease Assessment Scale-Cognitive Subscale, the primary outcome measure.
The relationship between the body shape of living pigs and their carcass morphology and composition (2004)

Abstract The conformation, tissue composition, and chemical composition of three types of pigs, given food ad libitum and slaughtered over a nominal live weight range of 35 to 115 kg, was assessed in relation to data provided on the live animals by a visual image analysis (VIA) system. The pig types were named as ‘3⁄4 Landrace’, ‘1⁄2 Pietrain’, and ‘1⁄4 Meishan’ types, representing ‘attenuated’, ‘blocky’, and ‘flabby’ types. Three analyses of the shape, conformation and composition data were performed. First, the relationship between conformation and age/size was assessed using linear regression of logarithmically transformed VIA and carcass data. In relation to age, ‘1⁄2 Pietrain’ pigs were found by both VIA and carcass measurements to have the widest shoulders. Both analyses also found this type to have the widest ham, trunk, and shoulders in relation to body length across most of the body length range studied, although the greatest rate of increase in ham width in relation to body length was found in the ‘1/4 Meishan’ type pigs. Second, the relationship between composition and VIA shape was examined using linear regression of transformed and standardized data. Significant relationships were found between fat, lipid, muscle, and protein weight and VIA shape, although relationships were weaker for protein and muscle weight. For fat and lipid, the VIA shape measures from the trunk region proved the most informative, whereas the VIA ham measures proved the most informative for muscle and protein. Third, detrended measures of composition/conformation and shape were used to remove the effect of animal size from the data. Removal of the variation due to growth generally led to substantial decreases in the adjusted R 2 statistics and in the R 2 -like statistics for prediction. Although in the models without detrending, relative fat and lipid weight had been found most strongly correlated with VIA shape, relative muscle was found most strongly correlated with shape in the detrended data. This was considered to result from the low between-animal variation in the data set combined with greater across-weight variation in fat and lipid weights than muscle and protein weights in the data without trend removal. Future trials with greater between-animal variation imposed would allow more precise determination of the relationship between conformation and shape.
Hardware in the loop for optical flow sensing in a robotic bee (2011)

Robot audition, which aims at multiple simultaneous human-robot communications in noisy environments, has undergone rapid development since last decade. For a common scenario, robot audition systems usually generate a huge amount of chronological data. These data fall into several categories: sound source locations and orientations, separated sound sources and recognized speeches. In order to efficiently assist people in understanding and analyzing the scenario, it is necessary to organize the data in a delicate way. To achieve this goal, we suggest Speech Arrow which conveys recognized speeches in animated arrow shaped frames. Speech Arrow is highly integrated, intuitive and vivid. In this paper, a single pane auditory scene visualizer is implemented to support Speech Arrow. The visualizer is 3D real-time virtual reality system based on the open source robot audition system HARK. It includes two versions, one of which restores original auditory scenes with offline raw data. The other analyzes and displays online instant data without any delay to help hearing impaired people. We demonstrate that our visualizer improves auditory awareness considerably with experiments.
Clot-selective coronary thrombolysis with pro-urokinase. (1989)

Recognition that myocardial infarction is caused by coronary thrombosis has stimulated a search for a safe, rapidly acting, and effective thrombolytic regimen. Tissue plasminogen activator (t-PA) can provide relatively clot-selective thrombolysis, but one quarter of patients fail to achieve reperfusion, lysis speed is not optimal, and higher doses have been associated with an increased incidence of hemorrhagic stroke. We report the results of a multicenter study of pro-urokinase, a second naturally occurring plasminogen activator that has structural similarities to t-PA but has a different mechanism of action. Pro-urokinase was administered 3.9 +/- 1.1 hours after the onset of chest pain to 40 patients with acute myocardial infarction with angiographically confirmed complete coronary occlusion (TIMI grade 0). After a 90-minute intravenous infusion of pro-urokinase (4.7-9 million units, 36-69 mg) 51% (20 of 39) of the patients demonstrated reperfusion (TIMI grade 2 or 3) occurring 64.8 +/- 22.3 minutes after initiation of therapy. Fibrinogen levels fell only 10 +/- 17% from baseline, confirming the fibrin specificity of pro-urokinase. As with t-PA, however, this specificity was only relative. alpha 2-Antiplasmin decreased to 39% and plasminogen decreased to 64% of initial values. Fibrinogen degradation products increased 63% and the fibrin-specific D-dimer increased 8.7-fold. Thus, pro-urokinase produces relatively clot-selective coronary thrombolysis similar to that produced by t-PA, but the use of either pro-urokinase or t-PA alone in higher doses would be likely to produce more nonspecific effects.
Intensity noise in diode-pumped single-frequency Nd:YAG lasers and its control by electronic feedback (1990)

The power spectrum of the relative intensity noise (RIN) of single-frequency diode-pumped Nd:YAG lasers is observed to be shot-noise limited at frequencies above 20 MHz for a photocurrent of up to 4.4 mA. Relaxation oscillations result in noise 60-70 dB above shot noise at a few hundred kilohertz. These relaxation oscillations have been suppressed using electronic feedback.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>