gebhart/patrepeval huggingface dataset:
Methane-Consuming Archaea Revealed by Directly Coupled Isotopic and Phylogenetic Analysis (2001)

Microorganisms living in anoxic marine sediments consume more than 80% of the methane produced in the world's oceans. In addition to single-species aggregates, consortia of metabolically interdependent bacteria and archaea are found in methane-rich sediments. A combination of fluorescence in situ hybridization and secondary ion mass spectrometry shows that cells belonging to one specific archaeal group associated with the Methanosarcinales were all highly depleted in 13C (to values of -96 per thousand). This depletion indicates assimilation of isotopically light methane into specific archaeal cells. Additional microbial species apparently use other carbon sources, as indicated by significantly higher 13C/12C ratios in their cell carbon. Our results demonstrate the feasibility of simultaneous determination of the identity and the metabolic activity of naturally occurring microorganisms.
De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints (2016)

Molecular evolution has focused on the divergence of molecular functions, yet we know little about how structurally distinct protein folds emerge de novo. We characterized the evolutionary trajectories and selection forces underlying emergence of β-propeller proteins, a globular and symmetric fold group with diverse functions. The identification of short propeller-like motifs (<50 amino acids) in natural genomes indicated that they expanded via tandem duplications to form extant propellers. We phylogenetically reconstructed 47-residue ancestral motifs that form five-bladed lectin propellers via oligomeric assembly. We demonstrate a functional trajectory of tandem duplications of these motifs leading to monomeric lectins. Foldability, i.e., higher efficiency of folding, was the main parameter leading to improved functionality along the entire evolutionary trajectory. However, folding constraints changed along the trajectory: initially, conflicts between monomer folding and oligomer assembly dominated, whereas subsequently, upon tandem duplication, tradeoffs between monomer stability and foldability took precedence.
Quantum Statistical Theory of Superradiance. I (1971)

We discuss the cooperative decay of initial atomic excitation for a pencil-shaped active volume filled with two-level atoms. As long as the length of the sample is much smaller than a certain maximal cooperation length, the atom-field interaction producing the superradiant pulse can be treated in terms of the simplest possible laser model (single mode). The basic laser master equation turns out to be exactly solvable if specified for the superradiance limit which is characterized by two conditions: (i) The photons escape from the low-$Q$ cavity so fast that they cannot feed themselves back into atomic excitation to any appreciable amount (this no-feedback condition is equivalent to the above-mentioned requirement for the length of the sample). (ii) The incoherent atomic decay due to natural relaxation is so slow that the individual atomic dipoles do not dephase before engaging themselves cooperatively in the interaction with the electromagnetic field. The present paper presents the derivation and general discussion of the equations describing the statistical properties of atoms and field in a superradiant pulse. Analytical and numerical solutions will be presented in a subsequent paper.
Synthesis and anti-proliferative activity evaluation of N3-acyl-N5-aryl-3,5-diaminoindazole analogues as anti-head and neck cancer agent (2014)

N3-acyl-N5-aryl-3,5-diaminoindazole analogues can be used as hits in the development of anticancer drug for HNSCC.
A Long Wavelength Fluorescent Hydrophilic Copolymer Based on Naphthalenediimide as pH Sensor with Broad Linear Response Range (2011)

Successful operation of a microbioreactor is dependent upon the monitoring and control of pH in culture fluids. Introducing chemosensors into polymeric backbones via covalent link can be easily employed to fabricate devices and chips fixed onto microbioreactors, capable of avoiding the phase separation and concentration quenching of chromophores. With hydrophilic poly(2-hydroxyethyl methacrylate) (PHEMA, the main matrix of contact lens), a novel hydrophilic fluorescent copolymer P(NDI–HEMA) containing the pendant group of naphthalenediimide moiety (NDI) as low-cost pH chemosensor film for high-throughput microbioreactor was designed. Its film exhibits great sensitivity and stability when measured in aqueous solution, possessing an obvious fluorescent response with an excellent linearity in the pH range of 4.6–8.0 with an apparent pKa of 6.0 corresponding to the methyl substituted piperidine nitrogen (N1) in NDI. The pH range is especially desirable to the fermentation monitoring of most industrially important microorganisms, such as various prokaryotes and eukaryotes. Furthermore, the long excitation wavelength at the isosbestic point of 572 nm and the emission band at about 630 nm of chromophore NDI brings several advantages such as low scattering, deep penetration, and minimal interfering absorption and fluorescence from biological system, showing a high promising application in bioprocess monitoring with a broad linear response range.
Design and field application of an automated cartridge sampler for VOC concentration and flux measurements (2005)

One of the major limitations in advancing the understanding of tropospheric ozone and aerosol generation and developing strategies for their control is the technical ability to accurately measure volatile organic compounds (VOCs). This paper describes the design of a constant flow VOC sampler. The versatile sampler can be used for fully automated concentration and flux measurements of VOCs. The sampler incorporates a microprocessor control unit and provides highly accurate mass flow control and significant ease of operation. Sampling sequences can be programmed directly or by remote control through a PC. All important operational parameters necessary for a complete sampling audit trail are logged. Compact weatherproof housings and low power consumption allow operation at remote sites and locations which are sensitive to disturbances or have restricted access. Inner wetted surfaces of the sampler are constructed from non-contaminating materials that do not sorb or emit VOC, and thus permit the collection of representative samples even in environments with very low VOC concentrations. The cartridge magazine provides a maximum of 20 sequential cartridge samples, which allows for long-term air quality assessments. In the dual channel mode, two samples can be collected simultaneously through two independent sample loops, providing ten sequential sample pairs. This design allows the parallel collection of (a) quality assurance backup samples, (b) samples on two different types of cartridges/sorbents to allow a variety of analyses, or (c) differential samples for flux measurements using enclosure, aerodynamic profile, or relaxed eddy accumulation (REA) methods. Field applications including airplane profile measurements above a tropical rainforest area, as well as gradient and REA measurements over a mid-latitude mixed forest stand are described, and demonstrate the validity and flexibility of the system. In particular, the application of the VOC sampler as an integrated part of a REA system is emphasized.
Lenguajes documentales y administración pública: análisis de tesauros en lengua española (2005)

A partir de la necesidad de contar con lenguajes documentales especificos como instrumentos para la descripcion informativa de contenido en los servicios de documentacion de las Administraciones publicas, se analizan y describen los seis Tesauros sobre Administracion Publica existentes en lengua espanola.
Government Under Law (2016)

OF LIFE for men, the individual is dependent upon cooperation with othersnot only for his peace and safetybut as well for the means of gaining the necessities of life and the development of his mental and moral faculties.This dependence is evident not only in the individual's necessary cooperation with the institutions of religion, the family, and social and economic society, but also in his necessary cooperation with law and government.Consequently dedicated men who conscientiously carry the heavy responsibilities of law and government may feel assured that God's blessing will be upon them.Law in our time is as broad as life itselfa seamless web which weaves its influence through all the important areas of livingeducation, commerce, labor, and the mass media of communications.For proof of this, we need look no further than the present phenomenon of our timesan unprecedented assault upon the Supreme Court for decisions covering issues in these diverse areas.Such attacks reflect deep and wide cleavages in public feeling.Now criticism is recognized as one of the powerful safeguards of American democracy.However, such criticism is valid only when it is rooted in honesty, fairness, and charity.Violence as a weapon of criticism or resistance must always be outlawed and condemned.If eternal vigilance be the price of freedom, then likewise a constant and willing acceptance of a constitutional law enshrining a divine truth is the surest guarantee of the reign of law in this nation.The final determination of these difficult issues will determine the law's function in such fundamental fields as the relation of federal and state authority; the scope of the jurisdiction of the legislature to investigate independent of judicial or executive delimitation; the law's proper balance
Lymphocyte Immunotherapy (LI) Increases Serum Levels of Progesterone Induced Blocking Factor (PIBF) (1997)

Leukocyte immunization causes an increase in PIBF in many cases. Possibly the improved pregnancy outcome in immunized patients with RSA or previous failure to conceive with in vitro fertilization may be partially or possibly completely explained by its stimulatory effect on PIBF.
Prediction of Flight-Level Radiation Hazards Due To Solar Energetic Protons (2006)

The radiation environment at aircraft altitudes is caused primarily by high-energy particles originating from outside the near-earth environment. These particles generally come from outside our solar system and are called galactic cosmic rays. Occasionally however, a transient solar event will also accelerate energetic protons toward the earth. If these protons reach the upper atmosphere, they produce secondary particles via collisions, resulting in increased radiation levels in the atmosphere. Air crews and electronic systems flying at high altitudes during one of these events are subjected to these increased levels of radiation which can result in health problems for personnel and soft errors in electronics. Much work has been performed to calculate radiation dose rates at flight levels due to non-solar energetic particles, however very few dose rate measurements have been made shortly after the eruption of a large solar flare. Using energetic proton data measured at geosynchronous orbits and Monte Carlo transport codes, an attempt is made to estimate radiation dose rates at different altitudes and locations during solar events. The goal is to provide accurate information about the radiation environment at high altitudes, which will allow aircraft and personnel to avoid locations where health or the mission may be negatively impacted.
Inhibitory effect of CO on internal anal sphincter: heme oxygenase inhibitor inhibits NANC relaxation (1993)

We examined the effect and role of CO in opossum internal anal sphincter (IAS) relaxation in response to nonadrenergic noncholinergic (NANC) nerve stimulation. Effects of NANC nerve stimulation on the IAS tension and second messengers (cAMP and cGMP) were examined before and after the selective heme oxygenase (HO) inhibitor zinc protoporphyrin IX (Zn PP-IX). The HO activity of the IAS smooth muscle was determined before and after NANC nerve stimulation. CO caused a concentration-dependent and tetrodotoxin-resistant fall in the resting tension of the IAS. The direct action of CO was confirmed by its relaxant action on the isolated smooth muscle cells. Furthermore, CO caused an increase in the tissue cGMP levels comparable to that observed with nerve stimulation. Zn PP-IX caused suppression of IAS relaxation caused by NANC nerve stimulation and vasoactive intestinal polypeptide (VIP) but not by peptide histidine-isoleucine and suppression of the increase in cGMP in response to NANC nerve stimulation. Zn PP-IX had no significant effect on the IAS responses to CO, nitric oxide (NO), and the beta-adrenoceptor agonist isoproterenol. The IAS responses to CO were not modified by the NO synthase inhibitor NG-nitro-L-arginine. Significant HO activity was detected in the IAS, which increased further in response to NANC nerve stimulation and VIP. The direct relaxant actions of CO and the suppression of NANC-mediated relaxation of the IAS by the HO inhibitor suggest the involvement of CO in the neurally mediated IAS relaxation.
Concurrent engineering: a prototyping case study (2003)

Vuman is a wearable portable computer used for navigation through electronic blueprints. Thirty working units of Vuman were designed and manufactured from system concept using a concurrent engineering design environment. The authors describe the steps in prototyping Vuman, using the suite of synthesis and analysis tools in the electronic and mechanical domains which comprise the concurrent engineering design environment. Some unforeseen problems and their proposed solutions are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pathophysiological role of nitric oxide and adrenomedullin in autism (2002)

Several studies indicate that nitric oxide (NO) is involved in the aetiopathogenesis of many neuropsychiatric disorders such as schizophrenia, bipolar disorder, depression, Alzheimer's disease, Hungtington disease and stroke. Although it has not been investigated yet, several recent studies proposed that NO may have a pathophysiological role in autism. Adrenomedullin (AM), a recently discovered 52-amino acid peptide hormone, induces vasorelaxation by activating adenylate cyclase and also by stimulating NO release. AM immune reactivity is present in the brain consistent with a role as a neurotransmitter. It has been stated that NO and AM do function in the regulation of many neurodevelopmental processes. We hypothesized that NO and AM activities have been affected in autistic patients and aimed to examine these molecules. Twenty-six autistic patients and 22 healthy control subjects were included in this study. AM and total nitrite (a metabolite of NO) levels have been measured in plasma. The mean values of plasma total nitrite and AM levels in the autistic group were significantly higher than control values, respectively (p < 0.001, p = 0.028). There is no correlation between total nitrite and AM levels (r = 0.11, p = 0.31). Certainly, this subject needs much further research investigating autistic patients in earlier periods of life and with subtypes of the disorder.
Enhanced Dielectric Properties of Tantalum Oxide Doped Barium Titanate based Ceramic Materials (2013)

The correlation between the dielectric properties and the structural characteristics of Ta2O5 (Tantalum Oxide) doped BaTiO3 (Barium Titanate) ceramics were investigated under different sintering conditions in this research. The raw materials of making Tantalum Oxide doped Barium Titanate were Ta2O5 and BaTiO3 powders (particle size =100 nm; purity better than 99%).Ta2O5 was doped at two different percentages viz. 0.5 and 1.0 mol%. Microstructure and fracture surface of sintered pellets were examined by a Scanning Electron Microscope (SEM). Dielectric properties were investigated by measuring the dielectric constant (k) as a function of temperature and frequency using an impedance analyzer. The results divulge that dielectric properties and microstructure of BaTiO3 ceramics were significantly influenced by the addition of a small amount of Ta2O5. Percent theoretical density above 90% was achieved in this research for 0.5 and 1.0 mol% Ta2O5 doped BaTiO3. It was observed that the grain size decreased markedly above a doping concentration of 0·5 mol% Ta2O5. Although fine grain size down to 200-300 nm was attained, grain sizes in the range of 1-1.8 μm showed the most alluring properties. The fine-grain quality and high density of the Ta2O5 doped BaTiO3 ceramic resulted in tenfold increase of dielectric constant. Stable value of dielectric constant, as high as 13000-14000 in the temperature range of 55 to 80 °C was found for 1.0 mol% Ta2O5 doped BaTiO3 with corresponding shift of Curie point to ~80 °C. Experimental results reveal that incorporation of a proper content of Ta2O5 in BaTiO3 could control the grain growth, shift the Curie temperature and hence significantly improve the dielectric property of the BaTiO3 ceramics.
Determination of Trace Amounts of Carbon Monoxide in Gaseous Hydrocarbons (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Trace Amounts of Carbon Monoxide in Gaseous HydrocarbonsK. H. Melson, M. D. Grimes, D. E. Smith, and B. J. HeinrichCite this: Anal. Chem. 1957, 29, 2, 180–183Publication Date (Print):February 1, 1957Publication History Published online1 May 2002Published inissue 1 February 1957https://pubs.acs.org/doi/10.1021/ac60122a003https://doi.org/10.1021/ac60122a003research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SCHOOLING AT SEA (1988)

Amid the enthusiasm for maritime uses of information technology, little attention has been paid to the potential of satellite communication for supporting distance-learning. The author describes the special advantages that a satellite link--by telephone, telex, facsimile or data transfer--can offer cadets aboard a ship, who might otherwise be faced with some learning difficulties in that others on board are unable to help with, or who might have to wait a long time for helpful comments from their tutors. He calls for all involved in maritime education and training to develop, as quickly as possible, the means of effectively using this technology.
자유논문 : 보호관찰청소년의 비행과 정신건강과의 관계 및 부모양육행동의 영향력 (2000)

본 연구는 보호관찰청소년의 비행이 정신건강과 상관관계가 있는가를 살펴보고 부모양육행동이 정신건강에 어떻게 영향을 미치는가를 밝히고자 하였다. 인구사회학적 배경변인, 친구관계를 고려한 상태에서 보호관찰청소년의 정신건강에 미치는 부모양육행동의 순수 영향력을 살펴보았다. 이를 위해 99년 7월 1일부터 8월 31일 기간 동안 서울시와 2개 중소도시의 보호관찰소에서 부모와 함께 사는 만 12∼14세를 대상으로 설문지 방식으로 실시하였으며, 최종 연구대상자는 154명이었다. 측정도구는 부모양육행동척도와 K- YSR을 사용하였다. 연구결과 보호 관찰청소년의 비행은 우울/불안, 위축, 신체증상과 각각 유의미한 상관관계를 나타내어 청소년의 비행이 정신건강과 밀접한 관련이 있음을 알 수 있었다. 어머니 양육행동 중 통제는 정신건강 하위변인 모두에 유의미한 영향력을 나타냈지만, 친밀감 및 합리성, 과잉보호, 방임과 같은 다른 양육행동요인은 통계적 영향력이 없었다. 아버지 양육행동의 경우 통제요인이 신체 증상, 위축에 영향력이 있었으나, 우울/불안에 의미 있는 영향력을 나타내지 않았다. 인구사회학적 배경변인, 친구관계를 고려한 상태에서 부모양육행동이 보호관찰청소년의 정신건강에 미치는 순수 영향력을 살펴본 결과, 아버지, 어머니의 통제, 아버지의 친밀감 및 합리성의 영향력이 통제하기 전보다 다소 감소하였으나, 여전히 유의미한 변인으로 나타났다. 결론적으로 어머니, 아버지의 통제, 아버지의 친밀감 및 합리성은 비행청소년의 정신건강에 영향력 있는 변인이라고 말할 수 있다. 따라서 보호관찰청소년의 정신건강증진과 더불어 비행의 재범을 예방하기 위한 상담 프로그램 및 부모교육 프로그램의 개발이 활성화되어야 하겠다.
PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosis (2010)

Serum amyloid P or pentraxin 2 (PTX2) is a highly phylogenetically conserved, naturally circulating plasma protein and a soluble pattern recognition receptor of the innate immune system. The unique binding activities of PTX2 suggest that it may localize specifically to sites of injury and function to aid in the removal of damaged tissue. The recent discovery of its ability to regulate certain monocyte differentiation states has identified PTX2 as a novel and potentially powerful antifibrotic agent. A fully recombinant form of the human PTX2 protein, designated PRM-151, has recently initiated human clinical trials. Here we review the molecular, cellular and structural biology of PRM-151/PTX2 in vitro and in several in vivo preclinical models of fibrotic disease that demonstrate its potential as a first-in-class natural modulator of fibrotic pathology with significant potential to treat a wide variety of human diseases.
The Effect of Synovial Tissue on the Breakdown of Articular Cartilage in Organ Culture (1977)

Abstract Living (pig) cartilage in contact with synovium lost both proteoglycan and collagen and sometimes became reduced to a mass of fibroblast‐like chondrocytes without matrix; dead cartilage lost proteoglycan but less collagen. Similar changes appeared in living cartilage grown at a distance from the synovium but in the same dish; dead cartilage was unaffected. Conclusion: the synovium has a) a direct, presumably enzymatic action on cartilage matrix and b) an indirect effect mediated through the chondrocytes.
Hydrogen Production from Nuclear Energy via High Temperature Electrolysis (2016)

This paper presents the technical case for high-temperature nuclear hydrogen production. A general thermodynamic analysis of hydrogen production based on high-temperature thermal water splitting processes is presented. Specific details of hydrogen production based on high-temperature electrolysis are also provided, including results of recent experiments performed at the Idaho National Laboratory. Based on these results, high-temperature electrolysis appears to be a promising technology for efficient large-scale hydrogen production.
THE PHYSIOLOGIC EFFECTIVENESS OF PROGESTERONE VAGINAL SUPPOSITORIES (1954)

Journal Article THE PHYSIOLOGIC EFFECTIVENESS OF PROGESTERONE VAGINAL SUPPOSITORIES Get access ROBERT B. GREENBLATT, M.D. ROBERT B. GREENBLATT, M.D. 1Medical College of Georgia Augusta, Georgia Search for other works by this author on: Oxford Academic Google Scholar The Journal of Clinical Endocrinology & Metabolism, Volume 14, Issue 12, 1 December 1954, Pages 1564–1567, https://doi.org/10.1210/jcem-14-12-1564 Published: 01 December 1954