gebhart/patrepeval huggingface dataset:
Synthesis and Structural Characterization of Schiff Base Cd(II) Complexes with One-Dimensional Chain Structure (2011)

The Schiff base ligand L was synthesized by the reaction of 1,4-(o-aminophenoxy)butane and acetyacetone.CdI2 reacted with L to give complex n(1).The complex was characterized by elemental analysis,FTIR and single crystal X-ray diffraction.The results of structural analysis indicated that the complex crystallized in the orthorhombic crystallize and space group Ccca,with the crystal cell parameters:a=1.70361(9)nm,b=4.5965(3)nm,c=2.48640(13)nm,V=19.4702(19)nm3,Z=16,Dc=1.715g·cm-3,R1=0.0466,wR2=0.1089.The coordination environment of Cd(Ⅱ) was a distorted tetrahedron,and in the complex,each L ligand linked two metal atoms using two terminal oxygen atom from acach-imine units belonging to two L ligands to generate a one-dimensional(1D)chain structure.
Antiestrogenic and antitumor properties of tamoxifen in laboratory animals. (1976)

This paper reviews the antiestrogenic and antitumor properties of tamoxifen (NSC-180973; ICI-46474) in the rat. In classic tests for antiestrogenic activity, tamoxifen inhibits the actions of estradiol in the rat uterus and vagina. At the cellular level, tamoxifen inhibits estrogen binding to cytoplasmic estrogen receptors, but although estrogen-receptor units are translocated to the nucleus DNA synthesis does not occur. It is suggested that tamoxifen competes for estrogen receptors in the cytoplasm and the false messenger units block the nuclear acceptors which are normally activated by estradiol-estrogen receptor complexes thereby provoking DNA synthesis. Tamoxifen inhibits the growth of some 7.12-dimethylbenz(a)anthracene-induced rat mammary tumors whereas others continue to grow. Estrogen-stimulated rises in plasma prolactin are only partially inhibited by tamoxifen although at the tumor level, tamoxifen completely blocks estrogen binding. There is a linear correlation (P less than 0.01) between estrogen-receptor levels in tumor biopsies before therapy and tumor responses to 3 weeks of tamoxifen treatment (50 mug/day) i.e., tumors with low levels of estrogen receptors do not respond to therapy whereas tumors with higher levels of estrogen receptors regress. It is suggested that tamoxifen antagonizes the actions of estrogen at the tumor level by blocking the estrogen-receptor mechanism thereby producing tumor regression. Therefore, estrogen-receptor measurements in tumor biopsies before therapy may be a useful predictive test for the tumor response to tamoxifen treatment.
Direct Effects of Protamine Sulfate on Myocyte Contractile Processes (1995)

The unique findings from the present study suggest that a fundamental contributory mechanisms for the changes in LV function observed after protamine administration may be the direct effect of unbound protamine on myocyte contractile processes.
Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. (1995)

Activation of the PDGF receptor on human arterial smooth muscle cells (SMC) induces migration and proliferation via separable signal transduction pathways. Sphingosine-1-phosphate (Sph-1-P) can be formed following PDGF receptor activation and therefore may be implicated in PDGF-receptor signal transduction. Here we show that Sph-1-P does not significantly affect PDGF-induced DNA synthesis, proliferation, or activation of mitogenic signal transduction pathways, such as the mitogen-activated protein (MAP) kinase cascade and PI 3-kinase, in human arterial SMC. On the other hand, Sph-1-P strongly mimics PDGF receptor-induced chemotactic signal transduction favoring actin filament disassembly. Although Sph-1-P mimics PDGF, exogenously added Sph-1-P induces more prolonged and quantitatively greater PIP2 hydrolysis compared to PDGF-BB, a markedly stronger calcium mobilization and a subsequent increase in cyclic AMP levels and activation of cAMP-dependent protein kinase. This excessive and prolonged signaling favors actin filament disassembly by Sph-1-P, and results in inhibition of actin nucleation, actin filament assembly and formation of focal adhesion sites. Sph-1-P-induced interference with the dynamics of PDGF-stimulated actin filament disassembly and assembly results in a marked inhibition of cell spreading, of extension of the leading lamellae toward PDGF, and of chemotaxis toward PDGF. The results suggest that spatial and temporal changes in phosphatidylinositol turnover, calcium mobilization and actin filament disassembly may be critical to PDGF-induced chemotaxis and suggest a possible role for endogenous Sph-1-P in the regulation of PDGF receptor chemotactic signal transduction.
Imidazoline Binding Sites on PC12 Cells and Bovine Chromaffin Cells (1995)

Stimulating actions of imidazolines on the adrenal medulla were demonstrated by several laboratories. As only a few data about signal transduction exist, the aim of the present study is to establish a cellular model on which both subtypes of imidazoline receptors are present. Binding studies using [3H]clonidine for I1-sites and [3H]idazoxan for I2-sites were performed on bovine chromaffin cells and a PC12 cell line. The intracellular calcium signal was determined by a Fura-2 signal using a fluorescence microscope. Both subtypes of imidazoline binding sites are present on either crude membrane fractions, purified plasma membranes, and mitochondrial membranes of the adrenal medulla. Although the density of I1- and I2-sites on the plasma membrane fraction is almost equal, on the mitochondrial membrane fraction Bmax of I2-binding sites was double that of the I1-binding number. An increase in intracellular calcium signal could be obtained during stimulation of chromaffin cells by various I1- and I2-receptor modulators. Because a saturation of I2-binding could not be obtained in PC12 cells, adrenal medullary chromaffin cells may be a more suitable model for investigating imidazoline receptor signal transduction.
Probabilistic Failure Detection for Efficient Distributed Storage Maintenance (2008)

Distributed storage systems often use data replication to mask failures and guarantee high data availability. Node failures can be transient or permanent. While the system must generate new replicas to replace replica lost to permanent failures, it can save significant replication costs by not replicating following transient faults. Given the unpredictability of network dynamics, however, distinguishing permanent and transient failures is extremely difficult. Traditional timeout approaches are difficult to tune and can introduce unnecessary replication. In this paper, we propose Protector, an algorithm that addresses this problem using network-wide statistical prediction. Our algorithm drastically improves prediction accuracy by making predictions across aggregate replica groups instead of single nodes. These estimates of the number of "live replicas" can guide efficient data replication policies. We prove that given data on node down times and the probability of permanent failures, the estimate given by our algorithm is more accurate than all alternatives. We describe two ways to obtain the failure probability function driven by models or traces. We conduct extensive simulations based both on synthetic and real traces, and show that Protector closely approximates the performance of a perfect "oracle" failure detector, while significantly outperforming timeout-based detectors using a wide range of parameters.
Insect monitoring with fluorescence lidar techniques: field experiments (2010)

Results from field experiments using a fluorescence lidar system to monitor movements of insects are reported. Measurements over a river surface were made at distances between 100 and 300 m, detecting, in particular, damselflies entering the 355 nm pulsed laser beam. The lidar system recorded the depolarized elastic backscattering and two broad bands of laser-induced fluorescence, with the separation wavelength at 500 nm. Captured species, dusted with characteristic fluorescent dye powders, could be followed spatially and temporally after release. Implications for ecological research are discussed.
The in vitro antitumor assay of 5-(Z)-arylidene-4-imidazolidinones in screens of AIDS-related leukemia and lymphomas (2001)

Thirty-one different 5-(Z)-arylidene-4-imidazolidinones were tested on six AIDS-related lymphoma (ARL) tumor cell lines, one leukemia CCRF-CEM cell culture and five different lymphoma cell lines: RL, KD-488, AS283, PA682 and SU-DHL-7. The investigated compounds showed remarkable activity against ARL, compounds 3d and 5c proved to inhibit AS283 and SU-DHL-7 cell lines, respectively, both at a GI50 value of 0.03 microM. The 2-(2-carboxyphenylamino) series proved to be the most active members in this investigation. Compounds 6b and 6d showed GI50 (MGMID) values of 6.1 and 8.7 microM, respectively, against the studied six ARL.
High-mobility field-effect transistors based on transition metal dichalcogenides (2004)

We report on fabrication of field-effect transistors (FETs) based on transition metal dichalcogenides. The unique structure of single crystals of these layered inorganic semiconductors enables fabrication of FETs with intrinsically low field-effect threshold and high charge carrier mobility, comparable to that in the best single-crystal Si FETs (up to 500 cm2/V s for the p-type conductivity in the WSe2-based FETs at room temperature). These FETs demonstrate ambipolar operation. Owing to mechanical flexibility, they hold potential for applications in “flexible” electronics.
Bacterial Peptidoglycan‐Associated Lipoprotein: A Naturally Occurring Toll‐Like Receptor 2 Agonist That Is Shed into Serum and Has Synergy with Lipopolysaccharide (2005)

Sepsis is initiated by interactions between microbial products and host inflammatory cells. Toll-like receptors (TLRs) are central innate immune mediators of sepsis that recognize different components of microorganisms. Peptidoglycan-associated lipoprotein (PAL) is a ubiquitous gram-negative bacterial outer-membrane protein that is shed by bacteria into the circulation of septic animals. We explored the inflammatory effects of purified PAL and of a naturally occurring form of PAL that is shed into serum. PAL is released into human serum by Escherichia coli bacteria in a form that induces cytokine production by macrophages and is tightly associated with lipopolysaccharide (LPS). PAL activates inflammation through TLR2. PAL and LPS synergistically activate macrophages. These data suggest that PAL may play an important role in the pathogenesis of sepsis and imply that physiologically relevant PAL and LPS are shed into serum and act in concert to initiate inflammation in sepsis.
Modeling image patches with a directed hierarchy of Markov random fields (2007)

We describe an efficient learning procedure for multilayer generative models that combine the best aspects of Markov random fields and deep, directed belief nets. The generative models can be learned one layer at a time and when learning is complete they have a very fast inference procedure for computing a good approximation to the posterior distribution in all of the hidden layers. Each hidden layer has its own MRF whose energy function is modulated by the top-down directed connections from the layer above. To generate from the model, each layer in turn must settle to equilibrium given its top-down input. We show that this type of model is good at capturing the statistics of patches of natural images. 1
What contributes to quality of life in patients with Parkinson's disease? (2000)

Depression, disability, postural instability, and cognitive impairment have the greatest influence on QoL in Parkinson's disease. The improvement of these features should therefore become an important target in the treatment of the disease.
Comparison of Pulmonary Function and Postoperative Pain After Laparoscopic Versus Open Gastric Bypass: A Randomized Trial (2001)

Laparoscopic gastric bypass resulted in less postoperative suppression of pulmonary function, decreased pain, improved oxygenation, and less atelectasis than open gastric bypass.
Turkey’s Islamist movement and the Palestinian cause: the 1980 ‘Liberation of Jerusalem’ demonstration and the 1997 ‘Jerusalem Night’ as case studies (2016)

The city of Jerusalem and the Palestine cause have been internalized by Islamist movements throughout the world as a pan-Islamic issue. Turkey’s Islamist movement, or the National Outlook Movement as it is known, has similarly appropriated Jerusalem as a cause to be defended against what it sees as Israeli encroachments. On two occasions in 1980 and 1997, the National Salvation Party and the Welfare Party, representing the Islamist movement, organized political demonstrations or events to highlight the significance of Jerusalem for the Muslim community and used it as an excuse to demand the introduction of Islamic law in an ardently secular country. These endeavours resulted in a backlash from the military, toppling the governments in power due to political instability and a purported threat to the secular nature of the regime.
The enduring psychosocial consequences of mania and depression (1993)

The psychosocial impairment associated with mania and major depression extends to essentially all areas of functioning and persists for years, even among individuals who experience sustained resolution of clinical symptoms.
An adaptive model for real-time estimation of overflow queues on congested arterials (2002)

The ability to estimate the status of current traffic congestion of a road network is of significant importance for many Intelligent Transportation Systems (ITS) applications such as in-vehicle route guidance systems (RGS) and advanced traffic management systems (ATMS). Substantial research effort has been dedicated to developing accurate and reliable techniques for estimation of various congestion measures such as link travel time and average travel speed. Few reliable models have however been reported, especially for congested arterials. This paper presents a model that can be used to estimate one of the congestion measures, namely real-time overflow queue at signalized arterial approaches. The model is developed on the basis of the principle of flow conservation, assuming that time-varying traffic arrivals can be obtained from loop detectors located at signalized approaches and signal control information is available online. A conventional microscopic simulation model is used to generate data for evaluation of the proposed model. A variety of scenarios representing variation in traffic control, level of traffic congestion and data availability are simulated and analyzed. The evaluation results indicate that the proposed model is promising in terms of the accuracy it can provide and advantages it has over existing models.
Conditional ablation of dendritic cells in transgenic mice. (1994)

Dendritic cells (DC) are professional Ag-presenting cells that play a major role in T cell-mediated immune responses and in thymocyte differentiation. To better analyze their physiological importance, we sought to generate transgenic mice presenting a conditional DC deficiency. We used a strategy based on the cell-specific expression of a suicide gene. The DC-targeted expression is obtained using HIV regulatory sequences; indirect evidence has suggested that these sequences control a preferential expression in DC. The suicide gene is the herpes simplex virus type 1 thymidine kinase (HSV1-TK) which allows conditional ablation of dividing HSV1-TK-expressing cells by converting nucleoside analogs such as ganciclovir (GCV) into toxic molecules. We generated transgenic mice expressing an HSV1-TK gene transcribed from HIV regulatory sequences. A low but significant HSV1-TK expression was observed in mature DC and DC precursors grown from granulocyte-macrophage colony-stimulating factor-supplemented bone marrow cultures. These HSV1-TK-expressing DC precursors are specifically killed by GCV. We next treated transgenic mice with GCV, and obtained a specific ablation of DC in spleen and thymus. Ninety percent of spleen DC could be depleted within a week, indicating a turnover rate of approximately 15% per day. Interestingly, this DC depletion always correlated with a major thymic atrophy and disappearance of CD4+CD8+ thymocytes. This animal model should help to assess the physiological role of DC in the immune response and in thymocyte differentiation. It should also help to appreciate the consequences of DC dysfunction in pathological situations, such as HIV-infection or allograft rejection.
Turbulence and the dynamics of coherent structures. II. Symmetries and transformations (1987)

1. Introduction. The accurate determination of coherent structures depends upon having a sufficiently large database. As we will see in this part, symmetry considerations can considerably extend the amount of available data. In addition, a priori consideration of symmetries can be significant in designing numerical or physical experiments. In the following we outline, on a case by case basis, and sometimes only in brief, the effect of such deliberations for a number of standard geometries. We then show how such data can be transformed for use in related geometries.
Properties of Mid-Ultraviolet Light Emitting Diodes Fabricated from Pseudomorphic Layers on Bulk Aluminum Nitride Substrates (2010)

High quality bulk aluminum nitride substrates were used to obtain pseudomorphic AlxGa1-xN layers with low dislocation density, smooth surfaces, and high conductivity. These layers were fabricated into mid-ultraviolet light emitting diodes with peak wavelengths in the range of 240–260 nm. The low dislocation density of the pseudomorphic quantum wells resulted in improved performance over previously published data. The output powers of the on-wafer measurements were greater than 5 mW in continuous wave operation, and 16 mW in pulsed operation. This was achieved utilizing single die (with an active area of 1×10-3 cm2).
The Electronic Structure and Chemistry of Solids (1987)

<italic>The Electronic Structure and Chemistry of Solids</italic> shows how the electronic structures and properties of solids can be described in terms familiar to chemists. Recent years have seen a considerable growth of interest in chemical aspects of the electronic structure of solids. The first three chapters give a fairly elementary account of the topics. The later chapters present slightly more advanced aspects, including many topics of current research interest, such as metal-insulator transitions, low-dimensional solids and “molecular metals”, and the properties of surfaces. The discussion is illustrated by a wide variety of examples.
An atomic clock based on a VCSEL-driven CPT resonance and a small 87Rb vapor cell (2007)

We report a high performance frequency standard based on Coherent Population Trapping, incited by a modulated VCSEL in the <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">87</sup> Rb-D <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> line. Short-term stabilities of σy=3×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-11</sup> /√τ and relative frequency deviations below 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-11</sup> /day were demonstrated.
New salicidation technology with Ni(Pt) alloy for MOSFETs (2001)

A novel salicide technology to improve the thermal stability of the conventional Ni silicide has been developed by employing Ni(Pt) alloy salicidation. This technique provides an effective avenue to overcome the low thermal budget (<700/spl deg/C) of the conventional Ni salicidation by forming Ni(Pt)Si. The addition of Pt has enhanced the thermal stability of NiSi. Improved sheet resistance of the salicided narrow poly-Si and active lines was achieved up to 750/spl deg/C and 700/spl deg/C for as-deposited Ni(Pt) thickness of 30 nm and 15 nm, respectively. This successfully extends the rapid thermal processing (RTP) window by delaying the nucleation of NiSi/sub 2/ and agglomeration. Implementation of Ni(Pt) alloyed silicidation was demonstrated on PMOSFETs with high drive current and low junction leakage.
Expression of CD4 + CD25+Treg cell in hepatocellular carcinoma and its clinical significance (2009)

Objective To investigate the role of regulatory T cells in the invation,advancement and prognosis of hepatocellular carcinoma (HCC).Methods The tumor tissue and the peripheral blood were collceted from forty five patients with every stage HCC;To contrast,the peripheral blood was collected from thirty healthy people at the same time.The population of CD4+,CD8+,CD4+ CD25+,CD4+ CD25+ CTLA4+ T subjects was evaluated by flow cytometry.Results cantly less than those of the healthy donors[(1.5± 0.4)× 109 vs (2.1±0.4)×109;(27.6±3.3) % vs (32.9± 5.8) %;cantly higher than those of the healthy donors[19.2±3.3) % vs (8.4±2.5) %;(8.6±2.2) % vs(2.1±0.8) %].And tumor tissue was obviously higher than that in the peripheral blood[(87.1±4.4) % vs (57.3± 3.3) %].Conclusions The quantity of regulatory T lymphocyte cells significantly correlated with tumor size,tumor thrombus and clinical stage in hepatocellular carcinoma (HCC) patients.And the increase in the number of CD4+ CD25+-Treg cell may be potential biological markers for invasion,advancement and prognosis of hepatocellular carcinoma (HCC).

Key words: 
Hepatocellular carcinoma; CD4+ CD25+-Treg cell; Flow cytometry; Immunosupression
<i>Fasciola hepatica in vitro</i>: increased susceptibility to fasciolicides in a defined serum-free medium (1987)

The cidal properties of some phenolic, halogenated diphenyl, salicylanilide, benzimidazole and diaminophenoxyalkane anthelmintics, against 6-week-old worms of Fasciola hepatica were assessed in vitro. In a conventional fluke culture medium containing RPMI 1640, supplemented with serum with or without rabbit erythrocytes or pink-ghosts, only the halogenated diphenyl and salicylanilide compounds showed activity at concentrations equal to or less than 100 microM. However, when basal, serum and cell-free RPMI 1640 was used, all compounds other than diamphenethide were highly active, their minimum lethal concentrations being some 25-125 times lower under these conditions. The inclusion of rabbit liver microsomes in the basal culture medium resulted in diamphenethide exhibiting cidal activity equivalent to that seen when its free-amine active metabolite was assayed. The possibility that the activity of many of these compounds was masked in vitro because of their serum binding properties is discussed. Recommendations are made that in vitro screens for new fasciolicides should be carried out in serum-free medium and that additional replicates containing mammalian liver microsomes and liver cytosolic extracts be included as means for the metabolic activation of certain otherwise undetectable prodrugs.
Rapid, long range inspection of chemical plant pipework using guided waves (2001)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation D. N. Alleyne, B. Pavlakovic, M. J. S. Lowe, P. Cawley; Rapid, long range inspection of chemical plant pipework using guided waves. AIP Conf. Proc. 30 April 2001; 557 (1): 180–187. https://doi.org/10.1063/1.1373757 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search