gebhart/patrepeval huggingface dataset:
Results of the first-in-human study of ABBV-075 (mivebresib), a pan-inhibitor of bromodomain (BD) and extra terminal (BET) proteins, in patients (pts) with relapsed/refractory (R/R) solid tumors. (2018)

2510 Background: BDs are protein domains that bind to acetylated histone tails, leading to upregulation of target genes driving oncogenesis. Inhibition of the BET family prevents assembly of the macromolecular complex and its transcriptional response. ABBV-075 is a pan-BET inhibitor that induces death in cell lines and tumor growth inhibition in xenograft models. This first-in-human, phase 1, two-part study (NCT02391480) assessed the safety and pharmacokinetics of ABBV-075 in pts with advanced tumors. Results from the dose escalation part in pts with solid tumors are reported. Methods: The dose escalation part of this open-label study enrolled adult pts with R/R solid tumors in a 3+3 fashion. Endpoints included maximum tolerated dose, recommended phase 2 dose (RP2D) at different ABBV-075 dosing schedules (daily, Monday/Wednesday/Friday [MWF], or 4 days on/3 off [4/7]), safety and preliminary efficacy. Results: As of Dec 2017, 72 pts with solid tumors enrolled in the dose escalation cohort. Most common tumors were: uveal/choroidal melanoma (n = 10); breast (n = 8); pancreatic (n = 6); head and neck (n = 5); and prostate (n = 3). Median age was 61.5 years (range 23–83); median treatment duration was 7.6 weeks (range 0.9–39.6). In total, 23, 27, and 22 pts entered the daily, MWF and 4/7 schedules. Overall, 71 pts (98.6%) reported ≥1 treatment-emergent adverse events (TEAEs); thrombocytopenia (56.9%), dysgeusia (48.6%), fatigue (43.1%) and nausea (34.7%) were most common. Grade 3/4 TEAEs were reported in 52 pts (72.2%); thrombocytopenia (30.6%) and anemia (15.3%) were most common; 11 pts died (none considered study drug related). Dose-limiting toxicities included thrombocytopenia, fatigue, aspartate aminotransferase elevation, gastrointestinal bleed and hypertension. The RP2D is 1.5 mg for the daily schedule, 2.5 mg for 4/7 and 3 mg for MWF. Of 65 evaluable pts, 25 pts (38.5%) had stable disease and 40 pts (61.5%) had progressive disease. Median progression-free survival was 1.8 months (95% CI: 1.8, 1.9). Conclusions: ABBV-075 has a tolerable safety profile and led to stable disease in some pts with malignant solid tumors. Clinical trial information: NCT02391480.
COMPOUND REPETITION IN OXIDE-OXIDE INTERACTIONS: THE SYSTEM Li<sub>2</sub>O-V<sub>2</sub>O<sub>5</sub> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCOMPOUND REPETITION IN OXIDE-OXIDE INTERACTIONS: THE SYSTEM Li2O-V2O5Arnold Reisman and Joan MineoCite this: J. Phys. Chem. 1962, 66, 6, 1181–1185Publication Date (Print):June 1, 1962Publication History Published online1 May 2002Published inissue 1 June 1962https://pubs.acs.org/doi/10.1021/j100812a048https://doi.org/10.1021/j100812a048research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The vitamin C content of quick frozen green beans (1975)

Summary The effect of maturity, variety, post‐harvest delay and various stages in processing, including cleaning, blanching and end‐cooking, on the vitamin C content of quick frozen green beans ( Phaseolus vulgaris ) has been studied. The vitamin C content of eight varieties showed considerable variation but no correlation with maturity was observed. Post‐harvest delay and processing caused a noticeable reduction in vitamin C content. The overall retention of vitamin C in both whole and sliced frozen beans was approximately 75%. After cooking, fresh manually sliced beans retained 59% of the original vitamin C content compared with 44% for the commercially frozen sliced beans.
Non-Foster Circuits for High Performance Antennas: Advantages and Practical Limitations (2016)

The demand for miniaturized, broadband communication systems has created a need for electrically small, broadband antennas. However, all passive electrically small antennas have a fundamental gain-bandwidth limitation related to their electrical size, as first described by Wheeler and Chu. This limitation can be overcome using active non-Foster circuits (negative inductors and/or negative capacitors), which can deliver a broadband input match with active matching techniques, or can help reduce phase dispersion using negative delay effects. This thesis will illustrate the advantages of non-Foster circuits in obtaining broadband small antennas, in addition to examining their practical limitations due to noise in receive applications, and nonlinearity in transmit applications.
Developing Age Appropriate Psychosexual Support for Adolescent Cancer Survivors: A Discussion Paper (2013)

Services provided for cancer survivors must consider the unique challenges facing different age groups. For young people diagnosed during adolescence and young adulthood there is a need to enhance the evidence base, and to apply this evidence in practice contexts. Locating the need for further developments within a Complex Intervention Framework may assist in the development of interventions that can be developed and tested in a logical, step-wise fashion.
Phylogenetic distribution of branched RNA-linked multicopy single-stranded DNA among natural isolates of Escherichia coli (1990)

Multicopy single-stranded DNA (msDNA), a branched DNA-RNA molecule, has been shown in Escherichia coli B and clinical strain Cl-1 to be synthesized by reverse transcriptase. We report that 13% of the strains of the ECOR collection, a sample of 72 E. coli isolates representing the breadth of genetic variation of the species, produce msDNA. Three of the four major subspecific groups include msDNA-producing strains. Screening of 25 isolates that are genetically related to msDNA-producing clinical strains uncovered 22 additional msDNA-producing strains. A phylogenetic tree based on allelic variation detected electrophoretically at 20 enzyme-encoding loci revealed two major clusters and several deep branches composed of strains that synthesize msDNA. Although E. coli K-12 does not harbor msDNA, other closely related strains of the K-12 family do. The results support the hypothesis that msDNA-synthesizing systems, including reverse transcriptase genes, were acquired recently and independently in different lineages of E. coli.
Intraphagocytic growth induces an antibiotic-resistant phenotype of Legionella pneumophila (1995)

The antimicrobial susceptibilities of Legionella pneumophila isolates grown either in U937 human monocytic cells or in Acanthamoeba polyphaga were studied after release from the host cells without further subculture. Time-survival studies showed that exposure of L. pneumophila cells, gown exclusively in vitro, to 5 micrograms of rifampin per ml resulted in at least 99% killing after 6 h and no detectable survivors at 24 h. Similar rates of killing were observed for in vitro-grown cells tested by exposure to ciprofloxacin. Conversely, time-survival studies revealed that macrophage-grown and amoeba-grown cells were ca. 1,000-fold more resistant to the activities of both drugs. Macrophage-grown cells treated with 5 micrograms of rifampin per ml showed 70 and 62% survival after 6 and 24 h, respectively. Intracellularly grown legionellae were also highly resistant to erythromycin (8 microgram/ml). After 24 h of exposure to the drug, there was 70 and 60% survival for amoeba-grown and macrophage-grown legionellae, respectively, whereas in vitro-grown cells showed a 2-log10 reduction in viable count. when intracellularly grown L. pneumophila cells were subcultured in broth for 48 h, they reverted to the phenotype characteristic of in vitro growth. Morphologically, the cells were larger than their intracellularly grown counterparts and resistance characteristics were lost. The susceptibilities of the subcultured cells to all three drugs were similar to those of Legionella cells grown exclusively in vitro. In view of these findings, the successful treatment of Legionnaires disease may be related as much to the resistance phenotype induced by intramacrophage growth as to the ability of the antibiotic to enter phagocytic cells.
Genotype/nutrition interactions in the ectomycorrhizal fungus <i>Hebeloma cylindrosporum</i> Romagnesi (1993)

SUMMARY Intraspecific variability in mycelial growth of the ectomycorrhizal basidiomycete Hebeloma cylindrosporum Romagnesi has been studied within 20 sib‐monokaryons, each being the progeny of one wild dikaryon fruiting in vitro , and the 50 synthesized dikaryons obtained from all the compatible fusions of these monokaryons. The interaction between fungal diversity and nutrition was also studied. The range of variation in mycelial growth (expressed as mg protein per culture) among the sib‐monokaryons was the same as that recorded among the synthesized dikaryons. The average growth of both mono‐ and dikaryons was highest on a synthetic medium containing nitrate as the sole nitrogen source, but showed the greatest variation. Fungal growth was approximately halved when nitrate was replaced by ammonium, and was intermediate on an organic nutrient‐rich medium. A decrease from 24 mM to 24 /M concentration of phosphorus reduced the average growth of the mycelia 40‐fold. The variation in mycelial growth in the synthesized dikaryons involved additive and non‐additive genetic components. Their ratio was variable depending on the nutrient conditions. In all cases but one, the interactive component was higher than the additive one. From an ecological point of view, these results emphasize the tremendous effect of nutrition on the phenotypic expression of fungal growth. Their possible significance for the dynamics of natural populations of ectomycorrhizal fungi is discussed.
Grid Impedance Identification Based on Active Power Variations and Grid Voltage Control (2007)

This paper presents a novel method for identification of grid impedance which can be applied to grid connected power converters. Active power variations together with grid voltage control are used to obtain two operating points necessary for the algorithm proposed. Grid currents and voltages in the two operating points are then reported to an arbitrary synchronous reference frame, resulting the equations for identification of inductive and resistive parts of grid impedance. Simulation and experimental results are used to validate the proposed algorithm in case of inductive and resistive grids. The accuracy of impedance identification is comparable to that of commercial products designed for grid impedance measurement.
Reaction of Methane with Copper Oxide in a Fluidized Bed (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of Methane with Copper Oxide in a Fluidized BedW. K. Lewis, E. R. Gilliland, and W. A. ReedCite this: Ind. Eng. Chem. 1949, 41, 6, 1227–1237Publication Date (Print):June 1, 1949Publication History Published online1 May 2002Published inissue 1 June 1949https://pubs.acs.org/doi/10.1021/ie50474a018https://doi.org/10.1021/ie50474a018research-articleACS PublicationsRequest reuse permissionsArticle Views559Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Effect of positive end-expiratory pressure on breathing patterns of normal subjects and intubated patients with respiratory failure (1983)

The aims of this study included assessment of accuracy of respiratory inductive plethysmography when pulmonary hyperinflation was induced by application of PEEP, and examination of breathing patterns of normal subjects, intubated patients requiring mechanical ventilation and intubated patients immediately before extubation during application of PEEP by demand valve and high gas flow reservoir bag systems. Validation of tidal volume (VT) and end-expiratory level measured with respiratory inductive plethysmography to simultaneous spirometry (SP) was achieved with PEEP levels up to 12.5 cm H2O in 7 normals. In 17 intubated patients, almost all VT values measured with respiratory inductive plethysmography fell within +/- 10% of SP even with 2 to 3 changes of body posture. In normal subjects, increasing levels of PEEP from the demand valve system produced nonprogressive rises of VT and mean inspiratory flow, falls of frequency and fractional inspiratory time (TI/TTOT), and no changes of minute ventilation (Vmin) nor mean expiratory flow. PEEP from the high gas flow reservoir bag system produced nonprogressive rises of VT and rib cage (RC) contribution to VT, and rises of Vmin and mean inspiratory and expiratory flows between 10.0 and 12.5 cm H2O of PEEP. Intubated patients requiring intermittent mandatory ventilation (IMV) had a rapid, shallow breathing pattern unaltered by PEEP levels delivered by either system up to 12.5 cm H2O despite increases of end-expiratory level. Intubated patients who were about to be extubated breathed with patterns closer to ambulatory normal subjects with the exception of their elevated RC contribution to VT.(ABSTRACT TRUNCATED AT 250 WORDS)
Epitaxial Growth of Silicon from the Pyrolysis of Monosilane on Silicon Substrates (1963)

Epitaxial films of silicon have been grown on silicon substrates by the pyrolysis of silane. Reaction kinetics have been investigated and the behavior shown to depend on the substrate temperature, being transport controlled above 1100°C and reaction controlled below this temperature. An over‐all activation energy and reaction order have been determined in this lower range. The initial mode of growth of the films has been studied by electron microscopy and electron reflection diffraction, which has shown that growth commences by a three‐dimensional nucleation process. Finally these results are compared with those obtained from films grown from in an effort to determine the nature of any mobile surface species.
One‐Step Hydrothermal Synthesis of Nitrogen‐Doped Carbon Nanotubes as an Efficient Electrocatalyst for Oxygen Reduction Reactions (2014)

A high amount of heteroatom doping in carbon, although favorable for enhanced density of catalytically active sites, may lead to substantially decreased electroconductivity, which is necessary for the electrochemical oxygen reduction reaction. Herein, a relatively low amount of nitrogen was successfully doped into carbon nanotubes (CNTs) by a hydrothermal approach in one step, and the synthesized nitrogen-doped CNT (CNT-N) materials retained most of the original, excellent characteristics, such as the graphitic structure, tubular morphology, and high surface area, of CNTs. The resultant CNT-N materials, although containing a relatively low amount of nitrogen doping, exhibited high electrocatalytic ORR activity, comparable to that of 20 wt% Pt/C; long durability; and, more importantly, largely inhibited methanol crossover effect.
Atmospheric Correction on Landsat ETM+ Satellite Image Based on FLAASH Model (2008)

The theory of FLAASH atmospheric correction was mainly introduced.FLAASH model was used to correct San Francisco ETM+ satellite image.Different land covers' spectral profiles and NDVI indexes were analyzed before and after FLAASH atmospheric correction.Result shows that the ETM+ satellite image can eliminate well with atmospheric effects after FLAASH model atmospheric correction.
The predictive value of peritubular capillaries C3d deposition in IgA glomerulonephritis (2005)

The IgA glomerulonephritis (IgAGN) is one of the most common primary glomerulonephritis and has a variable and difficult to predict evolution toward the end-stage nephrosclerosis. The deposition of C3d complement component in peritubular capillaries (PTCs) indicates a variant type of acute rejection while C3d deposition in primary glomerulonephritis (GN) is poorly documented. The aim of this study is to examine C3d expression in peritubular capillaries (PTCs) as a predictive marker and its correlation with the severity of renal injury in IgA glomerulonephritis. Polyclonal FITC conjugated rabbit anti-human C3c and C3d antibodies were used for direct immunofluorescent evaluation of the C3c and C3d deposits in 24 kidney biopsies with IgA glomerulonephritis. The study revealed that the C3d deposits in peritubular capillaries were associated with known predictors for rapid progression of IgAGN: glomerular sclerosis (63.6%), atrophic tubules (90.9%) and interstitial sclerosis (81.8%). The intensity of the C3c glomerular immunofluorescent deposits was related with active lesions. Thus, the predictive value of C3d deposition on PTCs in IgAGN is worth to be taken into consideration as an unfavorable outcome of the disease and request further long run investigations.
Progressive technique for human face image archiving and retrieval (1996)

A progressive region-based image compression technique is presented. This technique is based on the secondgeneration image compression paradigm, representing images as a union of homogeneous regions in harmony with the characteristics of the human visual system. The technique is progressive, allowing for an initial coarse version of the image to be reconstructed quickly from the compressed image data, and then refined through to the desired degree of fidelity. This paper describes how this technique can be applied to human face image archiving and retrieval. Compression results are provided and comparison with the JPEG standard is undertaken.
6.5kV RCDC: For increased power density in IGBT-modules (2014)

A reverse conducting IGBT in trench technology is presented. By this approach no carrier life time means are necessary to balance static and dynamic losses of the diode. The diode's p-emitter efficiency can be dynamically tailored by the applied gate voltage due to inversion charge carriers in the vicinity of the gate trench. This opens up the opportunity for a variety of gate control schemes with the aim of a charge carrier reduction before commutation thus reducing the recovery and the corresponding IGBT turn-on losses while the on-state diode losses remain low. A simple substitution of the IGBT and diode dies by the RCDC chips in the industry standard packages enables a significant increase of the power density (e.g. up to 30% for typical traction application) due to a thermal benefit given by lower thermal resistances as well as by a reduction of the dynamic losses due to special gate control.
Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis (2011)

The performance of the ThalesNano H-Cube(®), a commercial packed bed flow hydrogenator, was evaluated in the context of small scale reaction screening and optimization. A model reaction, the reduction of styrene to ethylbenzene through a 10% Pd/C catalyst bed, was used to examine performance at various pressure settings, over sequential runs, and with commercial catalyst cartridges. In addition, the consistency of the hydrogen flow was indirectly measured by in-line UV spectroscopy. Finally, system contamination due to catalyst leaching, and the resolution of this issue, is described. The impact of these factors on the run-to-run reproducibility of the H-Cube(®) reactor for screening and reaction optimization is discussed.
Timing optimization on routed designs with incremental placement and routing characterization (2000)

Wire delay estimation has been a problem in designs of very deep submicron (VDSM) technologies with feature size under 0.25 /spl mu/m. The conventional back-annotation approach does not guarantee timing convergence due to different estimation techniques for prelayout and post-layout timing. In this paper, a post-routing timing optimization algorithm is presented. Experimental results show that this algorithm provides better result after detail routing is completed.
Influence of ion energy and substrate temperature on the optical and electronic properties of tetrahedral amorphous carbon (<i>ta</i>-C) films (1997)

The properties of amorphous carbon (a-C) deposited using a filtered cathodic vacuum arc as a function of the ion energy and substrate temperature are reported. The sp3 fraction was found to strongly depend on the ion energy, giving a highly sp3 bonded a-C denoted as tetrahedral amorphous carbon (ta-C) at ion energies around 100 eV. The optical band gap was found to follow similar trends to other diamondlike carbon films, varying almost linearly with sp2 fraction. The dependence of the electronic properties are discussed in terms of models of the electronic structure of a-C. The structure of ta-C was also strongly dependent on the deposition temperature, changing sharply to sp2 above a transition temperature, T1, of ≈200 °C. Furthermore, T1 was found to decrease with increasing ion energy. Most film properties, such as compressive stress and plasmon energy, were correlated to the sp3 fraction. However, the optical and electrical properties were found to undergo a more gradual transition with the deposition temperature which we attribute to the medium range order of sp2 sites. We attribute the variation in film properties with the deposition temperature to diffusion of interstitials to the surface above T1 due to thermal activation, leading to the relaxation of density in context of a growth model.
Next‐Generation Biofuels: Survey of Emerging Technologies and Sustainability Issues (2010)

Next-generation biofuels, such as cellulosic bioethanol, biomethane from waste, synthetic biofuels obtained via gasification of biomass, biohydrogen, and others, are currently at the center of the attention of technologists and policy makers in search of the more sustainable biofuel of tomorrow. To set realistic targets for future biofuel options, it is important to assess their sustainability according to technical, economical, and environmental measures. With this aim, the review presents a comprehensive overview of the chemistry basis and of the technology related aspects of next generation biofuel production, as well as it addresses related economic issues and environmental implications. Opportunities and limits are discussed in terms of technical applicability of existing and emerging technology options to bio-waste feedstock, and further development forecasts are made based on the existing social-economic and market situation, feedstock potentials, and other global aspects. As the latter ones are concerned, the emphasis is placed on the opportunities and challenges of developing countries in adoption of this new industry.