gebhart/patrepeval huggingface dataset:
Rational Design of Multifunctional Polymer Therapeutics for Cancer Theranostics (2010)

Abstract Although anti‐angiogenic agents offer great therapeutic potential, preclinical and clinical studies suggest that these agents, used as monotherapies, have a delayed onset of activity and may have only limited effects on advanced malignancies. Multimodality targeted polymer therapeutics that include anti‐angiogenic agents and chemotherapeutics offer the potential for improved efficacy and diminished toxicity in the treatment of cancer and other angiogenesis‐dependent diseases. We have recently designed and characterized novel combined anti‐angiogenic and antitumor polymer–drug conjugates that target both the tumor and its microenvironment. These conjugates include combined anti‐angiogenic and chemotherapeutic drugs, such as TNP‐470 and paclitaxel, respectively. Several conjugates also incorporate bisphosphonates as targeting moieties for bone metastases and osteosarcomas or RGD peptidomimetics that target integrins overexpressed on tumor endothelial cells and several tumor cells. Using molecular imaging techniques, we have successfully established dormant and fast‐growing tumor mouse models to intravitally non‐invasively follow‐up tumor progression and response to novel polymer therapeutics. Our results point at our polymer therapeutics as novel bi‐specific conjugates targeting both the tumor epithelial and endothelial compartments, warranting their use on a wide spectrum of primary as well as metastatic tumors. The use of these novel architectures will potentially shed light on the molecular mechanisms underlying tumor dormancy and hopefully transform cancer into a chronically‐manageable disease.
Growing Old: Metabolic Control and Yeast Aging (2002)

The metabolic characteristics of a yeast cell determine its life span. Depending on conditions, stress resistance can have either a salutary or a deleterious effect on longevity. Gene dysregulation increases with age, and countering it increases life span. These three determinants of yeast longevity may be interrelated, and they are joined by a potential fourth, genetic stability. These factors can also operate in phylogenetically diverse species. Adult longevity seems to borrow features from the genetic programs of dormancy to provide the metabolic and stress resistance resources necessary for extended survival. Both compensatory and preventive mechanisms determine life span, while epigenetic factors and the element of chance contribute to the role that genes and environment play in aging.
A Petrophysical Evaluation of the Slave Point Formation, Cranberry Field, Alberta (1995)

Abstract Slave Point carbonates form a series of broad, low relief, reef complexes which grew in a restricted, shallow basin, the Cranberry Basin. This basin was bounded by the Peace River Arch to the south and the Presqu’ile Barrier Reef to the northwest. The largest gas field in this region is the Cranberry Field. The objective of this project was to perform a petrophysical evaluation of the Slave Point carbonates in the Cranberry Field. The results were incorporated into a regional exploration effort and were used in reserve evaluations. The Slave Point Formation is divided into three facies: platy stromatoporoid grainstones, amphipora mudstones to packestones, and bulbous stromatoporoid grainstones. These facies have a mixed limestone and dolomite lithology. Two productive rock types have been identified in the Cranberry Field. Limestones (grainstones) with intergranular porosity and fractured dolomites with vuggy porosity. The limestones have an intergranular pore network and smaller pore throats than the vuggy and fractured dolomites. The dolomites display much more variability in pore throat size and geometry, and exhibit a large scatter in rock properties measurements. Slave Point carbonates are at immobile Sw’s, and wells in the Cranberry Field produce virtually water-free. Dolomites associated with faults produce at up to ten times the rate of the limestones because of the contribution of fractures to flow capacity. Hydrocarbon pore volumes of limestones and dolomites are similar. Four wells, drilled into the vuggy dolomites account for two thirds of the gas, 67 Bscf, and all of the oil, 2.2 MMbbls, produced to date.
Molecular Properties of the <i>Xanthomonas</i> AvrRxv Effector and Global Transcriptional Changes Determined by Its Expression in Resistant Tomato Plants (2005)

The Xanthomonas campestris pv. vesicatoria avirulence gene AvrRxv specifies resistance on the tomato line Hawaii 7998 by interacting with three nondominant plant resistance genes. AvrRxv molecular properties that impinge on its avirulence activity were characterized and transcriptional changes caused by AvrRxv expression in resistant tomato plants were extensively examined. AvrRxv localized predominantly to the cytoplasm and possibly in association with plasma and nuclear membranes in both resistant and susceptible tomato plants. The AvrRxv cysteine protease catalytic core was found to be essential for host recognition, because introduction of mutations in this domain affected the ability of AvrRxv to elicit a hypersensitive response and the inhibition of bacterial growth in resistant plants. In addition, expression profiles were analyzed for approximately 8,600 tomato genes in resistant plants challenged with X. campestris pv. vesicatoria strains expressing wild-type AvrRxv or a catalytic core AvrRxv mutant. In all, 420 genes were identified as differentially modulated by the expression of a functional AvrRxv, including over 15 functional classes of proteins and a large number of transcription factors and signaling components. Findings of this study allow the development of new hypotheses about the molecular basis of recognition between AvrRxv and the corresponding resistance proteins, and set the stage for the dissection of signaling and cellular responses triggered in tomato plants by this avirulence factor.
Information theoretic measures of energy consumption at register transfer level (1995)

Article Free Access Share on Information theoretic measures of energy consumption at register transfer level Authors: Diana Marculescu Department of Electrical Engineering Systems, University of Southern California, Los Angeles, CA Department of Electrical Engineering Systems, University of Southern California, Los Angeles, CAView Profile , Radu Marculescu View Profile , Massoud Pedram Department of Electrical Engineering Systems, University of Southern California, Los Angeles, CA Department of Electrical Engineering Systems, University of Southern California, Los Angeles, CAView Profile Authors Info & Claims ISLPED '95: Proceedings of the 1995 international symposium on Low power designApril 1995 Pages 81–86https://doi.org/10.1145/224081.224096Published:23 April 1995Publication History 66citation426DownloadsMetricsTotal Citations66Total Downloads426Last 12 Months23Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Halogen-free imidazolium/ammonium-bis(salicylato)borate ionic liquids as high performance lubricant additives (2013)

Halogen-free bis(salicylato)borate anion based ionic liquids having imidazolium and ammonium cations, were designed, synthesized, characterized and then evaluated as potential lubricant additives. Owing to the high polarity, high London dispersive forces and high rigidity associated with the bulk size and ring structure of the bis(salicylato)borate anion, these ionic liquids possess very high viscosities. The interaction of these ionic liquids with contact surfaces has been found to be strongly influenced by the van der Waals interactions in the ionic liquids, which increases with an increase of the alkyl chain length, particularly, for the imidazolium cations. As lubricant additives, both imidazolium and ammonium ionic liquids markedly improve the friction-reducing and anti-wear properties of PEG 200 lube base. Microstructural images and element mapping of the worn surfaces of steel balls reveal that these ionic liquids form tribo-films, which reduces both the friction and wear. Being halogen-, phosphorus-, and sulfur-free, bis(salicylato)borate ionic liquids not only protect contact surfaces from tribo-corrosive events but also keep the environment green and clean. These ionic liquids offer an environmentally friendly alternative to conventional halogenated ionic liquids being currently developed for lubricant applications.
Flow sorting of antigen-binding B cell subsets. (1980)

Antigen binding was used as a probe in the definition of functional B cell heterogeneity. Unprimed, anti-Thy 1 and complement-treated spleen cells were stained with fluorescent trinitrophenylated bovine serum albumin (FL-TNP-BSA). These cells were sorted, fluorescence negative from fluorescence positive, by using a multiparameter cell sorter and assayed for precursor frequency in antibody responses to TNP by limiting dilution analysis. The cells that bound FL-TNP-BSA were demonstrated to be enriched for antibody-forming precursors to the antigens TNP-lipopolysaccharide (LPS), TNP-sheep red blood cells (SRBC), and TNP- or DNP-Ficoll, whereas the fluorescence negative cells were depleted for these responses. B cells that bound FL-TNP-BSA were then sorted into populations that bound a moderate or high amount of FL-TNP-BSA. The B cells responsive to TNP-LPS and TNP-SRBC were present in both the moderate and high binding populations. In contrast, the B cells responsive to TNP- or DNP-Ficoll were present only in the cells that bound a moderate amount of FL-TNP-BSA. These experiments suggest that there is a population of B cells in adult mouse spleen that binds large amounts of antigen, and that can respond to antigen carried on LPS or SRBC but not carried on Ficoll.
Evaluation of Sweet Corn Inbreds for Resistance for European Corn Borer1 (1976)

Abstract European corn borer ( Ostrinia nubilalis Hbn.) damage to sweet corn ( Zea mays L.) inbreds was evaluated by husk ratings, tip ratings, ear tunnel counts, and ear indexes for two years. Egg masses placed in the leaf whorl and on the ear shoot were used to simulate egg laying by first and second generation corn borer adults, respectively. Differences among inbreds for second generation corn borer ear damage were highly significant in both years. Husk rating and tip damage rating gave a consistent measurement of these differences in two markedly different seasons. Correlations for all measurements of second generation damage were highly significant within years. Measurements of first and second generation damage were not consistently related. Host maturity was negatively correlated, although not always significantly, with first and second generation damage parameters.
Optimizing outcomes in patients with rheumatoid arthritis and an inadequate response to anti-TNF treatment (2012)

A failure to respond to TNF inhibitors remains a serious concern for patients with RA. Although some patients experience a primary lack of drug efficacy in reducing their symptoms, others fail to maintain an initial response because of acquired drug resistance. While switching to another TNF inhibitor is a common practice for patients who are not responsive to a particular treatment, limited clinical trial data support this strategy. If more than one TNF inhibitor provides inadequate responses and/or similar tolerability issues, switching to a different class of agent may provide a more effective option. Currently four non-TNF inhibitors are approved for use in RA patients-the T-cell co-stimulation inhibitor abatacept, the B-cell-depleting mAb rituximab, the IL-1 receptor blocker anakinra and the IL-6 receptor inhibitor tocilizumab. These biologic agents have been studied in large, randomized placebo-controlled trials that demonstrate their efficacy in reducing disease activity in patients failing TNF inhibitor therapy. Results with the majority of these agents suggest that their administration may provide a greater proportion of patients with an effective, evidence-based disease-modifying approach earlier in the course of their disease than switching TNF inhibitors.
A method for simplifying linear dynamic systems (1966)

Often it is possible to represent physical systems by a number of simultaneous linear differential equations with constant coefficients, <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\dot{x} = Ax + r</tex> but for many processes (e.g., chemical plants, nuclear reactors), the order of the matrix A may be quite large, say 50×50, 100×100, or even 500×500. It is difficult to work with these large matrices and a means of approximating the system matrix by one of lower order is needed. A method is proposed for reducing such matrices by constructing a matrix of lower order which has the same dominant eigenvalues and eigenvectors as the original system.
Anti‐HTLV‐I IgG in urine detected by sensitive enzyme immunoassay (immune complex transfer enzyme immunoassay) using a synthetic peptide, Cys‐<i>env</i> gp46(188‐224), as antigen (1994)

Antibody IgG to human T-cell leukemia virus type I (HTLV-I) in urine was detected by a sensitive enzyme immunoassay (immune complex transfer enzyme immunoassay) using a synthetic peptide, Cys-env gp46(188-224), as antigen, the sensitivity and specificity of which were 100 and 98.5%, respectively, using serum samples. Anti-HTLV-I IgG in urine was reacted simultaneously with 2,4-dinitrophenyl-bovine serum albumin-Cys-env gp46(188-224) conjugate and Cys-env gp46(188-224)-beta-D-galactosidase (Escherichia coli) conjugate. The complex formed, consisting of the three components, was trapped onto polystyrene balls coated with affinity-purified (anti-2,4-dinitrophenyl group) IgG, eluted with epsilon N-2,4-dinitrophenyl-L-lysine and transferred to polystyrene balls coated with affinity-purified (anti-human IgG gamma-chain) IgG. Finally, bound beta-D-galactosidase activity was assayed by fluorometry. Thirty-one urine samples from seropositive subjects and 100 urine samples from seronegative subjects were tested. The sensitivity and specificity were 87 and 100%, respectively, with unconcentrated urine samples and 94 and 100%, respectively, with approximately 10-fold concentrated urine samples. These results were superior to those by the conventional ELISA and gelatin particle agglutination test.
Using Bidirectional Data Flow Analysis To Support Software Reuse (1994)

Ripple analysis, a form of program slicing, can be used to identify those parts of an existing system which provide specifiic functionality, thus supporting code reuse and other software development /maintenance activities. If a functional requirement is completely met by an identified set of input and output statements, forward ripple analysis for all input statements combined with backward ripple analysis for all output statements can identify all parts of the code related to that functionality. This paper describes a prototype static code analysis system for Pascal code that can be used to identify bi-directional ripples (based on data flow analysis). This system utilizes data flow analysis techniques to collect flow insensitive information about the variables in each source statement and build a database containing a call, control flow, and dead graph. This data base can then be used to identify forward and backward ripples of all appropriate input and output statements and thus th...
<title>Multimedia information retrieval by analyzing content and learning from examples</title> (1998)

Multimedia information systems are experiencing a tremendous growth as a direct consequence of the popularity and pervasive use of the world wide web. As a consequence, it is becoming increasingly important to provide efficient and flexible solutions for accessing and retrieving multimedia data. Images and video are emerging as significant data types in multimedia systems. And yet, most commercial systems are still text and keyword based and do not fully exploit the image content of these systems. We believe that there is an opportunity to build a novel interactive multimedia system for some specific applications in electronic commerce. In this paper, we present an overview of our approach, the rationale behind it and the problems that are inherent in building such a system. We address some of the technical issues in representing and analyzing image primitive features. These are the building blocks of any such systems. They can be generalized into a much broader range of applications as well.
Oxygenation of polychloro aromatic hydrocarbons by superoxide ion in aprotic media (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygenation of polychloro aromatic hydrocarbons by superoxide ion in aprotic mediaHiroshi Sugimoto, Shigenobu Matsumoto, and Donald T. SawyerCite this: J. Am. Chem. Soc. 1987, 109, 26, 8081–8082Publication Date (Print):December 1, 1987Publication History Published online1 May 2002Published inissue 1 December 1987https://pubs.acs.org/doi/10.1021/ja00260a021https://doi.org/10.1021/ja00260a021research-articleACS PublicationsRequest reuse permissionsArticle Views169Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antitumor activity of Sarcodon aspratus (BERK.) S. ITO and Ganoderma lucidum (FR.) KARST. (1989)

Antitumor activity of Sarcodon aspratus (Berk.) S. Ito and Ganoderma lucidum (Fr.) Karst. was investigated. Methanol and aqueous extracts of these Japanese mushrooms were tested for antitumor activity against solid type of sarcoma 180 by intraperitoneal or oral administration. The aqueous extract was remarkably effective for inhibition of tumor growth, but the methanol extract was not. The fraction of molecular weight more than 10000 had a high inhibitory activity against the tumor growth, but the fraction of molecular weight less than 10000 did not. Fractionation was carried out by using an ion-exchanger, and fraction S-4 having the highest carbohydrate content had the highest antitumor activity by intraperitoneal administration.
Cell-specific expression of B lymphocyte (APRIL, BLyS)- and Th2 (CD30L/CD153)-promoting tumor necrosis factor superfamily ligands in human placentas (2003)

Apoptosis-inducing tumor necrosis factor (TNF) ligands and receptors have been reported in human placentas, but the expression patterns of family members lacking this function [a proliferation-inducing ligand (APRIL), B lymphocyte stimulator (BLyS), CD30L/CD153, CD40L/CD154, TNF-related activation-induced cytokine, CD27L/CD70, OX40L, activation-inducible TNF receptor ligand (AITRL)] are incompletely documented or unknown. We therefore investigated expression of these eight ligands and nine of their receptors (B cell maturation antigen, transmembrane activator and calcium-modulator and cyclophilin ligand-interactor, CD30, CD40, receptor activator of nuclear factor-kappaB, osteoprotegerin, CD27, OX40/CD134, AITR). Analysis by reverse transcriptase-polymerase chain reaction revealed mRNAs encoding only three of the ligands (APRIL, BLyS, CD30L/CD153). Immunoblots demonstrated all three proteins in first-trimester and term placentas, and immunohistochemical experiments showed that expression was cell-specific and gestation-related. Although mRNAs encoding receptors for the three expressed ligands were absent, those encoding receptors for all of the unexpressed ligands were detectable. Collectively, the results are consistent with the postulate that nonapoptosis-inducing, placenta-derived TNF superfamily cytokines contribute to the T helper cell type 2 bias required for successful pregnancy. Patterns of placental expression of receptors suggest bidirectional maternal-fetal cytokine communication.
Peak-to-Average Power Ratio Reduction in MIMO-OFDM Systems Based on Decomposed Selected Mapping (2009)

The major drawback of multiple input multiple output orthogonal frequency division multiplexing system(MIMOOFDM) is its high peak-to-average power ratio(PAPR).To overcome this problem,a decomposed selected mapping(SLM) algorithm is proposed for MIMO-OFDM systems.In the proposed algorithm,the real and imaginary part of the candidate OFDM frames are treated separately,thus a sufficiently large number of alternative transmit signals are provided,which can achieve significant PAPR reduction performance without increase the numerical complexity due to the inherent conjugate symmetry property of real sequence.Moreover,a decomposed concurrent SLM algorithm is proposed,which can reduce the side information and thus improve the spectrum efficiency significantly. Simulation results demonstrate that the proposed algorithm can improve the PAPR performance effectively with the same complexity.
Polarization-sensitive terahertz detection by multicontact photoconductive receivers (2005)

We have developed a terahertz radiation detector that measures both the amplitude and polarization of the electric field as a function of time. The device is a three-contact photoconductive receiver designed so that two orthogonal electric-field components of an arbitrary polarized electromagnetic wave may be detected simultaneously. The detector was fabricated on Fe+ ion-implanted InP. Polarization-sensitive detection is demonstrated with an extinction ratio better than 100:1. This type of device will have immediate application in studies of birefringent and optically active materials in the far-infrared region of the spectrum.
Epitaxial lift-off GaAs/AlGaAs metal-semiconductor-metal photodetectors with back passivation (1993)

High-performance thin-film epitaxial lift-off (ELO) photodetectors have potential for integration with independently optimized integrated circuits and waveguides. In this paper, the dark current, responsivity, and frequency response of GaAs/AlGaAs metal-semiconductor-metal (MSM) photodetectors that remain on the growth substrate are compared to ELO detectors with and without back passivation. The passivated ELO detectors perform comparably to the on-wafer devices, while the unpassivated devices exhibit performance degradation. In addition to demonstrating the importance of back passivation, this paper presents the lowest ELO MSM dark current (5 nA at 5 V) for a 200- mu m-diameter device published to date.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Endoscopic stenting for post‐transplant biliary stricture: usefulness of a novel removable covered metal stent (2011)

Endoscopic treatment of post-LT AS using a removable FCSEMS is technically feasible, safe, and effective. This dedicated method may play an increasing role in the future management of benign biliary strictures.