gebhart/patrepeval huggingface dataset:
Lichtoptische Abbildung fokussierter Ultraschallfelder / Light optical imaging of focused ultrasonic field / Projection optique des champs d’ultra-son focalisées (1979)

Article Lichtoptische Abbildung fokussierter Ultraschallfelder / Light optical imaging of focused ultrasonic field / Projection optique des champs d’ultra-son focalisées was published on October 1, 1979 in the journal Materials Testing (volume 21, issue 10).
A Novel Telomere Structure in a Human Alternative Lengthening of Telomeres Cell Line (2005)

Cancer cells require mechanisms to maintain telomeres. Most use telomerase, but 5% to 20% of tumors use alternative lengthening of telomeres (ALT), a telomerase-independent mechanism that seems to depend on recombination. ALT is characterized by amplification of telomere TTAGGG repeats to lengths beyond 50 kb, by elevated rates of telomere recombination, and by nuclear structures called ALT-associated promyelocytic leukemia bodies. In Saccharomyces cerevisiae, survivors of telomerase inactivation also use recombination to maintain telomeres. There are two types of survivors, which differ in telomere structure. The first possesses telomere repeats and the Y' subtelomeric element amplified together as a tandem array at chromosome termini (type I), and the other possesses amplification of telomeric repeats alone (type II), similar to previously described human ALT cells. Here, we describe the first human ALT cell line having "tandem array" telomeres with a structure similar to that of type I yeast survivors. The chromosome termini consist of a repeat unit containing approximately 2.5 kb of SV40 DNA and a variable amount of TTAGGG sequence repeated in tandem an average of 10 to 20 times. Similar to previously described ALT cells, they show evidence of telomere recombination, but unlike standard ALT cells, they lack ALT-associated promyelocytic leukemia bodies and their telomeres are transcribed. These findings have implications for the pathogenesis and diagnosis of cancer.
Memory-system design considerations for dynamically-scheduled processors (1997)

In this paper, we identify performance trends and design relationships between the following components of the data memory hierarchy in a dynamically-scheduled processor: the register file, the lockup-free data cache, the stream buffers, and the interface between these components and the lower levels of the memory hierarchy. Similar performance was obtained from all systems having support for fewer than four in-flight misses, irrespective of the register-file size, the issue width of the processor, and the memory bandwidth. While providing support for more than four in-flight misses did increase system performance, the improvement was less than that obtained by increasing the number of registers. The addition of stream buffers to the investigated systems led to a significant performance increase, with the larger increases for systems having less in-flight-miss support, greater memory bandwidth, or more instruction issue capability. The performance of these systems was not significantly affected by the inclusion of traffic filters, dynamic-stride calculators, or the inclusion of the per-load non-unity stride-predictor and the incremental-prefetching techniques, which we introduce. However, the incremental prefetching technique reduces the bandwidth consumed by stream buffers by 50% without a significant impact on performance.
Strain Accomodation in the Footwall of the Rubys Inn Thrust Fault, Hillsdale Canyon, Southern Utah (2015)

The Rubys Inn thrust fault in southern Utah has produced several styles of deformation in its footwall. This project describes four exceptionally well exposed examples of strain accommodation, including a mountain-scale, ductile footwall drag fold, cataclastic flexural slip between bedding surfaces of differing competencies, plastically deformed petrified wood within the zone of flexural slip, and cataclastic shear expressed as deformation bands. Such examples show how various lithologies can be deformed into a wide array of structures during a single deformation event. Furthermore, some of these structures result in changes in permeability, which are important for those interested in subsurface fluid flow.
Tumor Suppressor Protein p53 Regulates Megakaryocytic Polyploidization and Apoptosis (2008)

The molecular mechanisms underlying differentiation of hematopoietic stem cells into megakaryocytes are poorly understood. Tumor suppressor protein p53 can act as a transcription factor affecting both cell cycle control and apoptosis, and we have previously shown that p53 is activated during terminal megakaryocytic (Mk) differentiation of the CHRF-288-11 (CHRF) cell line. Here, we use RNA interference to reduce p53 expression in CHRF cells and show that reduced p53 activity leads to a greater fraction of polyploid cells, higher mean and maximum ploidy, accelerated DNA synthesis, and delayed apoptosis and cell death upon phorbol 12-myristate 13-acetate-induced Mk differentiation. In contrast, reduced p53 expression did not affect the ploidy or DNA synthesis of CHRF cells in the absence of phorbol 12-myristate 13-acetate stimulation. Furthermore, primary Mk cells from cultures initiated with p53-null mouse bone marrow mononuclear cells displayed higher ploidy compared with wild-type controls. Quantitative reverse transcription-PCR analysis of p53-knockdown CHRF cells, compared with the "scrambled" control CHRF cells, revealed that six known transcriptional targets of p53 (BBC3, BAX, TP53I3, TP53INP1, MDM2, and P21) were down-regulated, whereas BCL2 expression, which is known to be negatively affected by p53, was up-regulated. These studies show that the functional role of the intrinsic activation of p53 during Mk differentiation is to control polyploidization and the transition to endomitosis by impeding cell cycling and promoting apoptosis.
Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides (2014)

Adenosine kinase (ADK) from Mycobacterium tuberculosis (Mtb) was selected as a target for design of antimycobacterial nucleosides. Screening of 7-(het)aryl-7-deazaadenine ribonucleosides with Mtb and human (h) ADKs and testing with wild-type and drug-resistant Mtb strains identified specific inhibitors of Mtb ADK with micromolar antimycobacterial activity and low cytotoxicity. X-ray structures of complexes of Mtb and hADKs with 7-ethynyl-7-deazaadenosine showed differences in inhibitor interactions in the adenosine binding sites. 1D (1)H STD NMR experiments revealed that these inhibitors are readily accommodated into the ATP and adenosine binding sites of Mtb ADK, whereas they bind preferentially into the adenosine site of hADK. Occupation of the Mtb ADK ATP site with inhibitors and formation of catalytically less competent semiopen conformation of MtbADK after inhibitor binding in the adenosine site explain the lack of phosphorylation of 7-substituted-7-deazaadenosines. Semiempirical quantum mechanical analysis confirmed different affinity of nucleosides for the Mtb ADK adenosine and ATP sites.
Los efectos de los sistemas de Bioprotección sobre la mortalidad vacuna en una cooperativa de Cuba (2013)

"El concepto de Bioseguridad abarca no sólo prevenir de enfermedades a los trabajadores de laboratorios, sino la liberación de organismos genéticamente modificados, el control de especies exóticas, de agentes biológicos y la inocuidad de los alimentos, así como la vida y la sanidad de los animales. El trabajo tuvo el objetivo de comparar los efectos específicos de algunos sistemas de Bioprotección con diferentes grados de deficiencias (Regular y Mal),sobre los índices de mortalidad general en bovinos de una cooperativa ganadera de Cuba, en los años 2009; 2010; y 2011.Se utilizaron los resultados de las evaluaciones en las unidades de la entidad en los años de referencia y se compararon los indicadores entre el total con evaluaciones cualitativas diferentes.Se utilizó la prueba de hipótesis de Z para la comparación de dos proporciones, estableciéndose nivel de significación (p<0.05). Para los análisis se utilizaron los programas Excel 2003 y Statistica Ver. 8, para Windows 2003. Los sistemas evaluados de Mal, especialmente los de Vigilancia Epizootiológica y Profilaxis específica, evidenciaron un significativo mayor efecto negativo que los evaluados de Regular.Se concluye que la magnitud de las deficiencias en los sistemas de Bioprotección, expresadas en términos de evaluación cualitativa integral de los últimos, condiciona mayor morbilidad y mortalidad consecuente."
Video retrieval based on scene change detection in compressed streams (1999)

This paper presents a new key frame extraction algorithm as well as a novel video-indexing scheme for a fast content-based browsing and retrieval in a video database. We first extract key frames by matching the AHIM (accumulated histogram intersection measure) of the DC image sequence constructed from the MPEG video sequence. Then we use the region segmentation-based projective histogram and its moments as database indices for video retrieval.
A double-blind, placebo-controlled trial of extracorporeal photopheresis in chronic progressive multiple sclerosis (1999)

Extracorporeal photopheresis is a safe therapy for cutaneous T-cell lymphoma and may have efficacy in certain autoimmune disorders. We performed a randomized, double-blinded, placebo-controlled trial of monthly photopheresis therapy in 16 patients with clinically definite multiple sclerosis (MS). All patients had progressed during the preceding year with entry Expanded Disability Status Scale (EDSS) scores between 3.0 and 7.0. Patients received photopheresis or sham therapy for 1 year and were followed for an additional 6 to 12 months. Patients were clinically evaluated by three disability scales: (1) EDSS; (2) Ambulation index and (3) Scripp's quantitative neurologic assessment. No serious side effects occurred in either group. There were no differences between the photopheresis and sham therapy groups by the disability measures. Additionally, there were no differences in progression of MRI plaque burden or evoked potential latencies. In this limited study, photopheresis was found to be safe but did not significantly alter the course of chronic progressive MS.
Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine/threonine kinase signaling pathway (2011)

The MYOCILIN gene encodes a secreted glycoprotein which is highly expressed in eye drainage structures. Mutations in this gene may lead to juvenile open-angle glaucoma and adult onset primary open-angle glaucoma, one of the leading causes of irreversible blindness in the world. Functions of wild-type myocilin are still unclear. We have recently demonstrated that myocilin is a modulator of Wnt signaling and may affect actin cytoskeleton organization. Here we report that myocilin and its naturally occurring proteolytic fragments, similar to Wnt3a, are able to stimulate trabecular meshwork, NIH3T3, and FHL124 cell migration with the N-terminal proteolytic fragment of myocilin lacking the olfactomedin domain producing the highest stimulatory effect. Stimulation of cell migration occurs through activation of the integrin-focal adhesion kinase (FAK)-serine/threonine kinase (AKT) signaling pathway. Inhibition of FAK by siRNA reduced the stimulatory action of myocilin by threefold. Activation of several components of this signaling pathway was also demonstrated in the eyes of transgenic mice expressing elevated levels of myocilin in the eye drainage structures. These data extend the similarities between actions of myocilin and Wnt proteins acting through a β-catenin-independent mechanism. The modification of the migratory ability of cells by myocilin may play a role in normal functioning of the eye anterior segment and its pathology including glaucoma.
Combining Crest Factor Reduction and digital predistortion with automatic determination of the necessary Crest Factor Reduction gain (2014)

Digital predistortion (DPD) and Crest Factor Reduction (CFR) are applied separately in radio frequency power amplifiers (PAs) in general. This paper proposes a method to jointly optimize DPD and CFR. For a given model of predistorter our solution gives automatically the Peak to average power ratio (PAPR) reduction gain to be applied by the CFR module. Within the DPD module PAPRs of original input signal and PA output and PAPR at predistorter output without CFR are used to estimate an optimal CFR gain through mathematical calculations. The combined CFR/DPD module ensures that the PAPR at the output of predistorter will not exceed a given limit. Hence, the envelope clipping module which is typically present to protect the PA, may be removed. In addition the proposed method offers a higher operating range of the DPD while fulfilling out-of band requirements and preserving low in-band distortion. Power efficiency of amplification module is improved as well. This solution has been tested by simulation and on a class AB LDMOS power amplifier in Agilent Advanced Design System (ADS).
A 9mW high band FM-UWB receiver front-end (2008)

A low-power FM-UWB receiver front-end for low data rate (100 kbps) short-range (≪10m) applications operating in the upper UWB band at 7.45GHz is described. The front-end comprises a 21 dB gain preamplifier and a 1GHz bandwidth FM demodulator. The measured receiver sensitivity is −86.8dBm while consuming 9mW from a 1.8V supply and −84.3dBm is achieved at 6mW power consumption. The 0.88mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> active area circuit is implemented in 0.25μm SiGe:C BiCMOS.
Fungal infections in cancer patients: an escalating problem. (1992)

Major advances in anticancer treatment have contributed to an increased frequency of severe fungal infections in patients with neoplastic diseases. Neutropenia remains the most important among the predisposing factors related to the malignancy or its treatment. Most fungal infections are caused by the commonly recognized opportunistic fungi Candida spp and Aspergillus spp, and the pathogenic fungi Cryptococcus neoformans, Histoplasma capsulatum, Coccidiodes immitis, and less often by Blastomyces dermatidis. However, recently newer pathogens such as Pheohyphomycetes, Hyalohyphomycetes, Zygomycetes and other fungi of emerging importance such as Torulopsis glabrata, Trichosporon beigelii, Malassezia spp, Saccharomyces spp, Hansenula spp, Rhodotorula spp, and Geotrichum candidum have appeared as significant causes of infection in this patient population. The increasing frequency of fungal infections is of great concern because of the difficulties in diagnosis and treatment. Amphotericin B remains the mainstay of antifungal treatment despite its toxicity and limited efficacy. Liposomal Amphotericin B may be more effective and less toxic. The activity of the azoles in immunocompromised patients is low. New azoles such as fluconazole and itraconazole may show future promise. The availability of the new granulocyte colony stimulating factors which can shorten the duration of neutropenia could represent a significant improvement in the management of fungal infections in cancer patients. As a preventive measure, the invasive procedures that predispose to infections should be done only when absolutely necessary and frequent handwashing by hospital personnel remains an effective prophylactic procedure.
Calcium Signaling by HBx Protein in Hepatitis B Virus DNA Replication (2001)

Hepatitis B virus (HBV) infects more than 300 million people and is a leading cause of liver cancer and disease. The HBV HBx protein is essential for infection; HBx activation of Src is important for HBV DNA replication. In our study, HBx activated cytosolic calcium-dependent proline-rich tyrosine kinase-2 (Pyk2), a Src kinase activator. HBx activation of HBV DNA replication was blocked by inhibiting Pyk2 or calcium signaling mediated by mitochondrial calcium channels, which suggests that HBx targets mitochondrial calcium regulation. Reagents that increased cytosolic calcium substituted for HBx protein in HBV DNA replication. Thus, alteration of cytosolic calcium was a fundamental requirement for HBV replication and was mediated by HBx protein.
The LabTube – a novel microfluidic platform for assay automation in laboratory centrifuges (2014)

Assay automation is the key for successful transformation of modern biotechnology into routine workflows. Yet, it requires considerable investment in processing devices and auxiliary infrastructure, which is not cost-efficient for laboratories with low or medium sample throughput or point-of-care testing. To close this gap, we present the LabTube platform, which is based on assay specific disposable cartridges for processing in laboratory centrifuges. LabTube cartridges comprise interfaces for sample loading and downstream applications and fluidic unit operations for release of prestored reagents, mixing, and solid phase extraction. Process control is achieved by a centrifugally-actuated ballpen mechanism. To demonstrate the workflow and functionality of the LabTube platform, we show two LabTube automated sample preparation assays from laboratory routines: DNA extractions from whole blood and purification of His-tagged proteins. Equal DNA and protein yields were observed compared to manual reference runs, while LabTube automation could significantly reduce the hands-on-time to one minute per extraction.
Recent Advances in Thermoplastic Elastomer Synthesis (1991)

Abstract A variety of living polymerization systems are now available for the controlled synthesis of block copolymers. Although living anionic polymerization remains as the method of choice for the most precise structural control, living polymerizations proceeding via other mechanistic types provide extremely useful extensions of this methodology to a wider variety of monomers.
Reproducibility of Aorta Segmentation on <scp>4D</scp> Flow <scp>MRI</scp> in Healthy Volunteers (2020)

Background Hemodynamic aorta parameters can be derived from 4D flow MRI, but this requires lumen segmentation. In both commercially available and research 4D flow MRI software tools, lumen segmentation is mostly (semi‐)automatically performed and subsequently manually improved by an observer. Since the segmentation variability, together with 4D flow MRI data and image processing algorithms, will contribute to the reproducibility of patient‐specific flow properties, the observer's lumen segmentation reproducibility and repeatability needs to be assessed. Purpose To determine the interexamination, interobserver reproducibility, and intraobserver repeatability of aortic lumen segmentation on 4D flow MRI. Study Type Prospective and retrospective. Population A healthy volunteer cohort of 10 subjects who underwent 4D flow MRI twice. Also, a clinical cohort of six subjects who underwent 4D flow MRI once. Field Strength/Sequence 3T; time‐resolved three‐directional and 3D velocity‐encoded sequence (4D flow MRI). Assessment The thoracic aorta was segmented on the 4D flow MRI in five systolic phases. By positioning six planes perpendicular to a segmentation's centerline, the aorta was divided into five segments. The volume, surface area, centerline length, maximal diameter, and curvature radius were determined for each segment. Statistical Tests To assess the reproducibility, the coefficient of variation (COV), Pearson correlation coefficient ( r ), and intraclass correlation coefficient (ICC) were calculated. Results The interexamination and interobserver reproducibility and intraobserver repeatability were comparable for each parameter. For both cohorts there was very good reproducibility and repeatability for volume, surface area, and centerline length (COV = 10–32%, r = 0.54–0.95 and ICC = 0.65–0.99), excellent reproducibility and repeatability for maximal diameter (COV = 3–11%, r = 0.94–0.99, ICC = 0.94–0.99), and good reproducibility and repeatability for curvature radius (COV = 25–62%, r = 0.73–0.95, ICC = 0.84–0.97). Data Conclusion This study demonstrated no major reproducibility and repeatability limitations for 4D flow MRI aortic lumen segmentation. Level of Evidence 3 Technical Efficacy Stage 2
Spectral shaping tradeoffs in Root-Raised-Cosine PDM-QPSK nonlinear transmission (2012)

We numerically investigate the WDM performance of RRC-PDM-QPSK systems, for variable dispersion management and channel spacing. We point out the optimal roll-off factors after nonlinear transmission and discuss the resulting trade-offs between spectral efficiency and performance.
Salvianolic Acid B Attenuates Toxin-Induced Neuronal Damage via Nrf2-Dependent Glial Cells-Mediated Protective Activity in Parkinson’s Disease Models (2014)

Salvianolic acid B (SalB), a bioactive compound isolated from the plant-derived medicinal herb Danshen, has been shown to exert various anti-oxidative and anti-inflammatory activities in several neurological disorders. In this study, we sought to investigate the potential protective effects and associated molecular mechanisms of SalB in Parkinson's disease (PD) models. To determine the neuroprotective effects of SalB in vitro, MPP+- or lipopolysaccharide (LPS)-induced neuronal injury was achieved using primary cultures with different compositions of neurons, microglia and astrocytes. Our results showed that SalB reduced both LPS- and MPP+-induced toxicity of dopamine neurons in a dose-dependent manner. Additionally, SalB treatment inhibited the release of microglial pro-inflammatory cytokines and resulted in an increase in the expression and release of glial cell line-derived neurotrophic factor (GDNF) from astrocytes. Western blot analysis illustrated that SalB increased the expression and nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). The knockdown of Nrf2 using specific small interfering RNA (siRNA) partially reversed the SalB-induced GDNF expression and anti-inflammatory activity. Moreover, SalB treatment significantly attenuated dopaminergic (DA) neuronal loss, inhibited neuroinflammation, increased GDNF expression and improved the neurological function in MPTP-treated mice. Collectively, these findings demonstrated that SalB protects DA neurons by an Nrf-2 -mediated dual action: reducing microglia activation-mediated neuroinflammation and inducing astrocyte activation-dependent GDNF expression. Importantly the present study also highlights critical roles of glial cells as targets for developing new strategies to alter the progression of neurodegenerative disorders.
Computing similarity in a reuse library system (1992)

This paper presents an AI based library system for software reuse, called AIRS, that allows a developer to browse a software library in search of components that best meet some stated requirement. A component is described by a set of ( feature, term ) pairs. A feature represents a classification criterion, and is defined by a set of related terms. The system allows to represent packages (logical units that group a set of components) which are also described in terms of features. Candidate reuse components and packages are selected from the library based on the degree of similarity between their descriptions and a given target description. Similarity is quantified by a nonnegative magnitude ( distance ) proportional to the effort required to obtain the target given a candidate. Distances are computed by comparator functions based on the subsumption, closeness, and package relations. We present a formalization of the concepts on which the AIRS system is based. The functionality of a prototype implementation of the AIRS system is illustrated by application to two different software libraries: a set of Ada packages for data structure manipulation, and a set of C components for use in Command, Control, and Information Systems. Finally, we discuss some of the ideas we are currently exploring to automate the construction of AIRS classification libraries.