gebhart/patrepeval huggingface dataset:
Regulation of atrial natriuretic factor receptors by angiotensin II in rat vascular smooth muscle cells. (1988)

Atrial natriuretic factor (ANF) is actively involved in the control of blood pressure and fluid homeostasis as a physiological antagonist of the renin-angiotensin system. To evaluate a possible interaction between ANF and angiotensin II (Ang-II) receptors, we investigated the effect of long term pretreatment (18 h) of rat cultured vascular smooth muscle cells with Ang-II. Binding of 125I-labeled ANF and cyclic GMP production induced by ANF were measured. After preincubation of the cells with Ang-II (1, 10, and 100 nM), the number of ANF binding sites (Bmax) was decreased by 30, 59, and 71%, respectively, with a slight decrease of the Kd values. Sar1-Ile8-Ang-II (100 nM), a specific Ang-II receptor antagonist, totally inhibited the down-regulation induced by Ang-II (10 nM). Moreover, the regulatory effect of Ang-II on ANF receptors appeared more slowly as compared to ANF homologous receptor regulation. Ang-II pretreatment did not desensitize but increased cyclic GMP production elicited by ANF, implying that only the number of non-guanylate cyclase-coupled receptors was affected. These findings, which were not observed with 100 nM of epinephrine, norepinephrine, histamine, serotonin, and Arg-vasopressin, demonstrate a specific and functional link between ANF and Ang-II receptors. This study also shows that the regulation of ANF receptors is heterogeneous, providing new evidence of multiple classes of ANF receptors.
A Facile One-Pot Synthesis of Alkyl Aryl Sulfides from Aryl Bromides (2004)

A convenient one-pot synthetic method for the formation of alkyl aryl sulfides from various alkyl halides and lithium aryl thiolates that are prepared in situ by direct halogen-lithium exchange is reported. In particular, the method overcomes many of the problems encountered in previous reports; it is very quick, catalyst-free, and does not involve use of unstable aryl thiols.
Differential Evolution Algorithm with Space Reduction for Solving Large-Scale Global Optimization Problems (2017)

Differential evolution algorithm (DE) is one of the most applied meta-heuristics algorithm for solving global optimization problems. However, the contributions of applying DE for large-scale global optimization problems are still limited compared with those problems for low dimensions. In this chapter, a new differential evolution algorithm is proposed in order to solve large-scale optimization problems. The proposed algorithm is called differential evolution with space partitioning (DESP). In DESP algorithm, the search variables are divided into small groups of partitions. Each partition contains a certain number of variables and this partition is manipulated as a subspace in the search process. Searching a limited number of variables in each partition prevents the DESP algorithm from wandering in the search space especially in large-scale spaces. The proposed algorithm is investigated on 15 benchmark functions and compared against three variants DE algorithms. The results show that the proposed algorithm is a cheap algorithm and obtains good results in a reasonable time.
Some Methodological Problems in Reflection-Impulsivity Research (1976)

AULT, RUTH L.; MITCHELL, CHRISTINE; and HARTMANN, DONALD P. Some Methodological Problems in Reflection-Impulsivity Research. CmLD DEVELOPMENT, 1976, 47, 227-231. 2 statistical characteristics of the Matching Familiar Figures test produce methodological problems in reflection-impulsivity research. The first characteristic is low reliability of error rates which results in 4 problems: frequent errors of classification, regression effects in repeatedmeasures designs not employing a control group, statistically insignificant effects in small sample studies when error rate is manipulated, and underestimation of correlations between errors and other variables unless corrected for attenuation. The second characteristic is the moderate negative correlation between latency and error rate which makes 2 X 2 analyses of variance on latencies and errors problematic. The main and interaction effects resulting from such an analysis may be confounded, and artificial dichotomization of continuous variables such as latency and errors results in loss of statistical power.
Selective Removal of Plasma Components by High‐Performance Immunoaffinity Chromatography (1997)

Affinity chromatography employing immobilized antibody is a rapid and specific technique for isolating biologically active materials from different sources, and high-performance immunoaffinity chromatography (HPIAC) has been used to isolate antibodies and antigens for medical application. In an attempt to resolve the problem of amyloid deposition in dialysis patients, we used HPIAC to specifically remove beta2-microglobulin from human plasma. The use of a membrane as an affinity ligand support was also studied. The specific antibody immobilized on a membrane was highly effective for removal of rat immunoglobulin E passed through an extracorporeal circulation system (ECS). Then we investigated the removal of injected human serum amyloid P component from the blood of rats by means of the ECS. Biocompatibility of the specific antibody-bearing immunoaffinity membrane was also examined in terms of nonspecific binding of other plasma components. These techniques should prove useful for medical application and may have broad applicability for the elimination of any unwanted plasma component.
Symptomatic Relapse of HIV‐Associated Cryptococcal Meningitis after Initial Fluconazole Monotherapy: The Role of Fluconazole Resistance and Immune Reconstitution (2006)

After initial treatment with fluconazole, relapses of symptomatic CM are often associated with fluconazole resistance and immune reconstitution inflammatory syndrome. These data add to concern about the efficacy of fluconazole, compared with amphotericin B, for initial treatment of HIV-associated CM.
Proboscis Conditioning Experiments with Honeybees,<i>Apis Mellifera Caucasica,</i>with Butyric Acid and DEET Mixture as Conditioned and Unconditioned Stimuli (2010)

Three experiments are described investigating whether olfactory repellents DEET and butyric acid can support the classical conditioning of proboscis extension in the honeybee, Apis mellifera caucasica (Hymenoptera: Apidae). In the first experiment DEET and butyric acid readily led to standard acquisition and extinction effects, which are comparable to the use of cinnamon as a conditioned stimulus. These results demonstrate that the odor of DEET or butyric acid is not intrinsically repellent to honey bees. In a second experiment, with DEET and butyric acid mixed with sucrose as an unconditioned stimulus, proboscis conditioning was not established. After several trials, few animals responded to the unconditioned stimulus. These results demonstrate that these chemicals are gustatory repellents when in direct contact. In the last experiment a conditioned suppression paradigm was used. Exposing animals to butyric acid or DEET when the proboscis was extended by direct sucrose stimulation or by learning revealed that retraction of the proboscis was similar to another novel odor, lavender, and in all cases greatest when the animal was not permitted to feed. These results again demonstrate that DEET or butyric acid are not olfactory repellents, and in addition, conditioned suppression is influenced by feeding state of the bee.
From Bathroom to Ballroom- Terry Cloth (1953)

Terry cloth is stepping forward this year to pace the fashions in clothes and interior decoration for homemakers and coeds alike.
Emerging cognitive radio applications: A survey (2011)

Recent developments in spectrum policy and regulatory domains, notably the release of the National Broadband Plan, the publication of final rules for TV white spaces, and the ongoing proceeding for secondary use of the 2360-2400 MHz band for medical body area networks, will allow more flexible and efficient use of spectrum in the future. These important changes open up exciting opportunities for cognitive radio to enable and support a variety of emerging applications, ranging from smart grid, public safety and broadband cellular, to medical applications. This article presents a high-level view on how cognitive radio (primarily from a dynamic spectrum access perspective) would support such applications, the benefits that cognitive radio would bring, and also some challenges that are yet to be resolved. We also illustrate related standardization that uses cognitive radio technologies to support such emerging applications.
Clustering structure analysis in time-series data with density-based clusterability measure (2019)

Clustering is used to gain an intuition of the structures in the data. Most of the current clustering algorithms produce a clustering structure even on data that do not possess such structure. In these cases, the algorithms force a structure in the data instead of discovering one. To avoid false structures in the relations of data, a novel clusterability assessment method called density-based clusterability measure is proposed in this paper. It measures the prominence of clustering structure in the data to evaluate whether a cluster analysis could produce a meaningful insight to the relationships in the data. This is especially useful in time-series data since visualizing the structure in time-series data is hard. The performance of the clusterability measure is evaluated against several synthetic data sets and time-series data sets, which illustrate that the density-based clusterability measure can successfully indicate clustering structure of time-series data.
Substituent effects on the physical properties and pKa of aniline (2000)

The aniline molecule is nonplanar, with its NH2 group lying at an angle θ of approximately 42° to the plane of the benzene ring. Substituents on the phenyl ring alter this out-of-plane angle as well as other molecular properties such as the ring bond lengths and angles, the barrier to inversion Einv, and the pKa of the amino group. Ab initio 6-311G** quantum chemical calculations have been employed to examine these substituent influences and the extent to which they are interrelated. Electron-donating substituents increase the CN bond length R(CN), θ, Einv, and the pKa, whereas electron-withdrawing substituents have the opposite effect. Among the molecular parameters that might serve as regression indicators for these changes, Hammett σ constants, which traditionally have been used to represent substituent electronic effects, yield fair to good correlations for R(CN) (r2=0.797), θ (r2=0.804), Einv (r2=0.829), and the amino group pKa (r2=0.931) for aniline and 18 substituted anilines. Of several measures of atomic charge, the Mulliken and electrostatic charges on the amino nitrogen atom show essentially no correlation with these properties. In contrast, the natural charge Qn on the amino nitrogen is well correlated with the bond length R(CN) (r2=0.889), θ (r2=0.932), Einv (r2=0.839), and the amino group pKa (r2=0.960). This latter result suggests that the natural charge, rather than either the Mulliken or electrostatic charges, may be the preferred charge descriptor for correlation purposes. Inclusion of electron correlation at the MP2 level increases the correlations of Einv with both σ (r2=0.951) and Qn (r2=0.892). © 2000 John Wiley & Sons, Inc. Int J Quant Chem 80: 1107–1115, 2000
The dynamic VideoBook: A hierarchical summarization for surveillance video (2013)

This paper proposes a novel hierarchical summarization system for surveillance video in which synopsis video and original video are at the lower layer and dynamic collage at the higher layer. A user can efficiently browse the video content through dynamic zooming into collage images and further skimming synopsis video or original video for details, enabling an interactive interface for video navigation. We call this system Dynamic VideoBook because its structure is akin to a book, that is, dynamic collage images resemble the cover and the contents while synopsis video gives an abridged edition of the video. Unlike previous collage techniques for films or entertainment videos, collage for surveillance video is challenging since such video imposes restrictions on spatiotemporal relationship and focus on multiple foreground objects. So we put forward a new collage method which better conveys the spatiotemporal motion and structurally extracts the visual contents from the video simultaneously. And we also enable dynamic zooming in to reveal more information in real-time. In addition, by mapping the upper layer of sketchy visualization to the lower layer of visual data, this system can efficiently explore and browse the video content, highlight one motion or interactively search one specific fragment.
Metachromasy of Basic Dyestuffs (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetachromasy of Basic DyestuffsL. Michaelis and S. GranickCite this: J. Am. Chem. Soc. 1945, 67, 7, 1212–1219Publication Date (Print):July 1, 1945Publication History Published online1 May 2002Published inissue 1 July 1945https://doi.org/10.1021/ja01223a055RIGHTS & PERMISSIONSArticle Views361Altmetric-Citations206LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (805 KB) Get e-Alerts Get e-Alerts
Toughening of epoxy resins with aromatic polyesters (2000)

Polyesters, prepared by direct polycondensation from bisphenol A and aliphatic dicarboxylic acids [adipic acid (AD), suberic acid, sebacic acid (SE), and dodecanedioic acid], were used to improve the toughness of the diglycidyl ether of the bisphenol A/diaminodiphenyl methane epoxy system. Polyesters had the number average molecular weight (Mn) ranging from 4300 to 19,200 g/mole. The epoxy systems modified with the AD system (Mn = 6400 g/mole) and the SE system (Mn = 10,200 g/mole) showed phase separated structures with discrete domains of 0.2 μm, but other systems showed smooth fracture surfaces when observed by scanning electron microscopy. The modified epoxy systems except for the AD system and SE system showed two tan δ peaks corresponding to the α and β transitions of the epoxy resin. The modified epoxy systems showed maximum values of K1c at around 10 wt % of polyester and maximum flexural properties at 5 wt % of polyester. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 78: 2464–2473, 2000
Association of Short-Chain Fatty Acids in the Gut Microbiome With Clinical Response to Treatment With Nivolumab or Pembrolizumab in Patients With Solid Cancer Tumors (2020)

Results of this study suggest that fecal SCFA concentrations may associated with PD-1i efficacy; thus, SCFAs may be the link between the gut microbiota and PD-1i efficacy. Because fecal examinations are completely noninvasive, they may be applicable for routine monitoring of patients.
Plasma 1,5-Anhydro-D-Glucitol as New Clinical Marker of Glycemic Control in NIDDM Patients (1989)

To elucidate the value of using plasma 1,5-anhydro-D-glucitol (AG) as a marker of glycemic control in diabetic patients, the relationship between the plasma concentration of AG and glucosuria was examined in 152 patients with non-insulin-dependent diabetes mellitus (NIDDM). After recovery from the deterioration of glycemic control in NIDDM patients had started, AG began to increase day by day. The recovery of plasma AG showed a constant linear increase curve when excellent glycemic control was attained. The ordinary daily recovery rate of plasma AG was estimated to be 0.3 microgram/ml, which was independent of body weight, sex, age, the difference in treatment, the duration of diabetes, or the level of plasma AG among NIDDM patients. This rate decreased according to the increase in urinary glucose. When we calculated the decrease rate of plasma AG (delta AG), assuming 0.3 microgram/day to be the maximum increase rate in a day, we found a high correlation between delta AG and urinary glucose at almost all AG levels except the normal range and observed that plasma AG (A) times urinary glucose (G) was relatively constant. The formula A x G = 16 is a simple equation for rough estimation of urinary glucose from the plasma AG concentration in a stable glycemic-controlled NIDDM patient, and we call it the A.G index. The plasma AG also correlated significantly with fasting plasma glucose (r = -.810) and glycosylated hemoglobin (r = -.856) in the same stable glycemic-controlled NIDDM patients. Based on these observations, we propose that plasma AG can serve as a new marker that may provide sensitive and analytical information about glycemic control.
SLA2 mutations cause SWE1-mediated cell cycle phenotypes in Candida albicans and Saccharomyces cerevisiae (2009)

The early endocytic patch protein Sla2 is important for morphogenesis and growth rates in Saccharomyces cerevisiae and Candida albicans, but the mechanism that connects these processes is not clear. Here we report that growth defects in cells lacking CaSLA2 or ScSLA2 are associated with a cell cycle delay that is influenced by Swe1, a morphogenesis checkpoint kinase. To establish how Swe1 monitors Sla2 function, we compared actin organization and cell cycle dynamics in strains lacking other components of early endocytic patches (Sla1 and Abp1) with those in strains lacking Sla2. Only sla2 strains had defects in actin cables, a known trigger of the morphogenesis checkpoint, yet all three strains exhibited Swe1-dependent phenotypes. Thus, Swe1 appears to monitor actin patch in addition to actin cable function. Furthermore, Swe1 contributed to virulence in a mouse model of disseminated candidiasis, implying a role for the morphogenesis checkpoint during the pathogenesis of C. albicans infections.
Propert ies of Concrete with Municipal Solid Waste Incinerator Bottom Ash (2012)

Th e appropriate utilization of Municipal Solid Waste Incineration (MSWI) residues is a worldwide studied topic over the last decades. One of the possibilities is to use MSWI ashes in concrete production, as it is done with coal combustion products. The bottom ash features the most convenient composition for this purpose, and it is available in highest amounts among the MSWI ashes. Untreated bottom ash was used as partial replacement of sand in concrete; strength was not negatively affected up to 10 % replacement, the prepared concrete had sufficient durability. The longer-time behavior of concrete with bottom ash differed from the control material due to presence of sulfates and chlorides in bottom ash. Keyw ords: m unicipal solid waste incineration; bottom ash; concrete; compressive strength; durability
In search of I/O-optimal recovery from disk failures (2011)

We address the problem of minimizing the I/O needed to recover from disk failures in erasure-coded storage systems. The principal result is an algorithm that finds the optimal I/O recovery from an arbitrary number of disk failures for any XOR-based erasure code. We also describe a family of codes with high-fault tolerance and low recovery I/O, e.g. one instance tolerates up to 11 failures and recovers a lost block in 4 I/Os. While we have determined I/O optimal recovery for any given code, it remains an open problem to identify codes with the best recovery properties. We describe our ongoing efforts toward characterizing space overhead versus recovery I/O tradeoffs and generating codes that realize these bounds. 1
Preventive Effects of Chlorophyllin Fixed on Chitosan towards DNA Adduct Formation of 3-Amino-1-methyl-5<i>H</i>-pyrido[4,3-<i>b</i>]indole in CDF<sub>1</sub> Mice (2002)

Chlorophyllin, a water-soluble derivative of chlorophyll, is known to suppress the mutagenic and carcinogenic action of compounds having polycyclic structures, e.g., heterocyclic amines and aflatoxin B1. Recently, we reported that chlorophyllin fixed on chitosan (chl-chitosan), which is insoluble in water, can efficiently and tightly trap these heterocyclic amines. We have studied whether this adsorption to chl-chitosan can result in an interference with DNA-adduct formation caused by 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), a heterocyclic amine, in CDF1 mice, in which Trp-P-2 had been shown to induce hepatocellular carcinomas. Mice were fed a diet containing Trp-P-2 with or without chl-chitosan. After 3 d of feeding, DNA-adduct formation in liver and lung was examined by 32P-postlabeling analysis. Adducts formed from Trp-P-2 were significantly decreased by the chl-chitosan addition (p<0.05, t-test). These results suggest that the uptake of Trp-P-2 into the mouse was lowered by its adsorption to chl-chitosan, either within the digestive tract or within the food itself. This trapping agent, chl-chitosan, is thus worthy of study for cancer chemoprevention.
Polysaccharides as a Marker for Detection of Corn Sugar Syrup Addition in Honey (2009)

Honey is a natural product of high quality. However, because of its limited production and of its relatively high price, some beekeepers or unscrupulous traders do not hesitate to modify and falsify this natural product in order to try to increase its market value. Then, these involved falsification practices, for example intentional addition of cheap sugar syrup to honeys, are sometimes difficult to detect. An effective and simple analytical method is proposed in order to detect adulteration in honey by analysis of polysaccharide profiles. Samples were previously treated with reversed-phase solid phase extraction first to remove monosaccharides and small oligosaccharides and second to concentrate simultaneously traces of polysaccharides. A chromatographic separation using anion exchange stationary phase and pulse amperometric detection was further performed. Polysaccharide fingerprints (degree of polymerization from 11 to 17) were shown to be present in laboratory doped samples, and not detectable or present at very low concentrations in the authentic honey samples. Application to acacia, mountain polyfloral and polyfloral honeys enabled readily the detection of fraud resulting from deliberate addition of 1% of corn syrup.
Experience with Implanted Electrodes at Rancho Los Amigos Hospital (1977)

Implanted units, manufactured by Medtronic, Inc., have been implanted in 31 patients for treatment of drop-foot. The principal problem encountered in this series is inflammatory reaction, which was observed in 7 patients and was serious enough in 5 to require removal. Theree have been no failures of the implanted equipment for periods of up to 7.3 years, although there is currently a question in 1 patient. There has also been no documented damage to the nerve due to chronic stimulation. Fine wire electrodes have been implanted intraneurally in a series of animals and in 3 patients. Preliminary results look encouraging, and this approach seems to hold considerable promise for a new generation of electrode design.