gebhart/patrepeval huggingface dataset:
RUBY-LASER-PUMPED OPTICAL PARAMETRIC OSCILLATOR WITH ELECTRO-OPTIC EFFECT TUNING (1967)

Optical parametric oscillation has been achieved in LiNbO3 in the range 1 to 1.08 μ with a peak parametric power of 38 × 103 W. The oscillator which was tuned both by rotation of the crystal in an external optical cavity and by the electro-optic effect was pumped at 6943 Å by a ruby laser of 3 × 106 W peak power. The observed electro-optic tuning agreed with that calculated from measured values of the electro-optic coefficients.
Big Data Security and Privacy Issues in the CLOUD (2016)

Many organizations demand efficient solutions to store and analyze huge amount of information. Cloud computing as an enabler provides scalable resources and significant economic benefits in the form of reduced operational costs. This paradigm raises a broad range of security and privacy issues that must be taken into consideration. Multi-tenancy, loss of control, and trust are key challenges in cloud computing environments. This paper reviews the existing technologies and a wide array of both earlier and state-ofthe-art projects on cloud security and privacy. We categorize the existing research according to the cloud reference architecture orchestration, resource control, physical resource, and cloud service management layers, in addition to reviewing the recent developments for enhancing the Apache Hadoop security as one of the most deployed big data infrastructures. We also outline the frontier research on privacy-preserving data-intensive applications in cloud computing such as privacy threat modeling and privacy enhancing solutions.
A Frameshift Mutation in<i>RPGR</i>Exon ORF15 Causes Photoreceptor Degeneration and Inner Retina Remodeling in a Model of X-Linked Retinitis Pigmentosa (2006)

XLPRA2 is an early-onset model of XLRP that is morphologically characterized by abnormal photoreceptor maturation followed by progressive rod-cone degeneration and early inner retina remodeling. The results suggest that therapeutic strategies for this retinal degeneration should target not solely photoreceptor cells but also inner retinal neurons.
The Limitations and Usefulness of C-Reactive Protein and Elastase-α<sub>1</sub>-Proteinase Inhibitor Complexes as Analytes in the Diagnosis and Follow-up of Sepsis in Newborns and Adults (1994)

C-reactive protein and elastase-alpha 1-proteinase inhibitor complexes were compared in the diagnosis of neonatal sepsis and bacterial infections in adults on the intensive care unit. Both analytes were measured in the same sample immediately after receipt. EDTA-plasma samples (n = 115) from 28 neonates (gestational age 29-42 weeks) within the first 72 hours of life with suspected neonatal sepsis, 2 babies between 14 and 28 days old with B-streptococcus infections and 28 adults on the intensive care unit with positive bacterial cultures were analysed for both analytes. Two adults with long-term infections were followed up over a period of 28 and 65 days respectively. The results showed that in 17 cases of confirmed neonatal sepsis within the first 24 hours of life, c-reactive protein levels were undetectable in 16 cases, one level of 13 mg/l being recorded. All had elevated elastase-alpha 1-proteinase inhibitor concentrations. Of the remaining 15 samples, 13 were normal and 2 were borderline for this analyte. C-reactive protein levels were between 5 and 10 mg/l in 5 cases and undetectable in the remaining 10 samples. Those neonates with detectable c-reactive protein levels were between 20 and 72 hours old with a gestational age greater than 31 weeks. C-reactive protein was undetectable in samples taken at the same time interval after birth from full-terms babies with a gestational age of 41-42 weeks, even in confirmed cases of neonatal sepsis.(ABSTRACT TRUNCATED AT 250 WORDS)
Mutations in a CCHC zinc-binding motif of the reovirus sigma 3 protein decrease its intracellular stability (1994)

It has been demonstrated that the sigma 3 protein of reovirus harbors a zinc-binding domain in its amino-terminal portion. A putative zinc finger in the CCHH form is located in this domain and was considered to be a good candidate for the zinc-binding motif. We performed site-directed mutagenesis to substitute amino acids in this region and demonstrated that many of these mutants, although expressed in COS cells, were unstable compared with the wild-type protein. Further analysis revealed that zinc-binding capability, as measured by retention on a zinc chelate affinity adsorbent, correlates with stability. These studies also allowed us to identify a CCHC box as the most probable zinc-binding motif.
[M<sub>3</sub>(μ<sub>3</sub>-O)(O<sub>2</sub>CR)<sub>6</sub>] and related trigonal prisms: versatile molecular building blocks for crystal engineering of metal–organic material platforms (2014)

This review details the emergence of metal–organic materials (MOMs) sustained by high symmetry trigonal prismatic molecular building blocks (MBBs).
Synthesis of Some Thienotetrahydroquinoline Derivatives (2004)

Abstract 2‐Thioxo‐1,2,5,6,7,8‐hexahydroquinoline‐3‐carbonitrile ( 2 ) was easily S‐alkylated to produce alkyl mercapto derivatives 3a‐g . The latter compounds were cyclized to afford thienotetrahydroquinolines 4a‐g . Several pyrimidothienotetrahydroquinolines 5a‐d , and 6a‐d were obtained from the condensation of compounds 4c‐f with different reagents. o‐Aminocarbohydrazide derivative 11 was reacted with aromatic aldehydes, acetylacetone, nitrous acid and CS 2 to afford compounds 12–15 . Compound 24 was coupled with aryldiazonium chloride to afford arylazo derivatives 25 . Also it condensed with aromatic aldehydes to give arylidene derivatives 26 . The latter compounds were reacted with malononitrile to give pyrano derivative 27 .
A single-chip quad-band (850/900/1800/1900 MHz) direct conversion GSM/GPRS RF transceiver with integrated VCOs and fractional-n synthesizer (2002)

Recent trends in the integration of entire systems on-chip have spurred the development of homodyne radios as alternatives to the more mature yet harder to integrate superheterodyne architectures. This paper presents a monolithic device that integrates all of the functions necessary to implement a multiband homodyne global system for mobile telecommunications (GSM) radio except for the power amplifier (PA) and radio frequency (RF) passives. The single BiCMOS chip includes a quad-band direct conversion receiver that down converts RF to quadrature analog baseband. The front-end circuitry is followed by a low-DC-offset, high-dynamic-range, analog I/Q baseband chain. The transmit section is comprised of a quad-band up-conversion transmit phase-locked loop (PLL) including on chip transmit voltage-controlled oscillators (VCOs). The stringent GSM receive band phase noise specifications are met without the use of surface acoustic wave filters. A single /spl Sigma//spl Delta/ fractional-N synthesizer locking a fully integrated ultrahigh frequency VCO generates the system local oscillator signal.
<title>Integration of waveguides for optical detection in microfabricated analytical devices</title> (2000)

Buried optical channel waveguides integrated with a fluidic channel network on a planar microdevice are presented. The waveguides were fabricated using silica-on-silicon technology with the goal to replace bulk optical elements and facilitate various optical detection techniques for miniaturized total analysis systems or lab-on-a-chip systems. Waveguide structures with core layers doped with germanium were employed for fluorescence measurements, while waveguides with nitrogen- only doped core layers were used for absorbance measurements. By the elimination of germanium oxygen deficiency centers transmission of light down to 210nm was possible, allowing absorance measurements in the mid and far UV region (210 to 280nm), which is the region where a large number of different molecules absorb light. Robust, alignment-free microdevices, which can easily be hooked up to a number of light sources and detectors were used for fluorescence measurements of two dyes, fluorescein and Bodipy, and absorbance measurements of a stres-reducing drug, propranolol. The lowest detected concentrations were 250pM for fluorescein, 100nM for Bodipy and 12(mu) M for propranolol.
Conducting Polymers Directly Coated on Reduced Graphene Oxide Sheets as High-Performance Supercapacitor Electrodes (2012)

In this work, conducting polymers poly(3,4-ethylenedioxythiophene) (PEDOT), polyaniline (PANi), and polypyrrole (PPy) were directly coated on the surface of reduced graphene oxide (RGO) sheets via an in situ polymerization process to prepare conducting-polymer-RGO nanocomposites with different loadings of the conducting polymers. Experiment results showed that ethanol played an important role in achieving a uniform coating of the polymers on RGO sheets. The electrochemical capacitive properties of the composite materials were investigated by using cycle voltammetry and charge/discharge techniques. The composite consisting of RGO and PANi (RGO-PANi) exhibited a specific capacitance of 361 F/g at a current density of 0.3 A/g. The composites consisting of RGO and PPy (RGO-PPy) and PEDOT (RGO-PEDOT) displayed specific capacitances of 248 and 108 F/g, respectively, at the same current density. More than 80% of initial capacitance retained after 1000 charge/discharge cycles, suggesting a good cycling stability of the composite electrodes. The good capacitive performance of the conducting–polymer-RGO composites is contributed to the synergic effect of the two components.
From Machine Learning to Natural Product Derivatives that Selectively Activate Transcription Factor PPARγ (2009)

Advanced kernel-based machine learning methods enable the identification of innovative bioactive compounds with minimal experimental effort. Comparative virtual screening revealed that nonlinear models of the underlying structure–activity relationship are necessary for successful compound picking. In a proof-of-concept study a novel truxillic acid derivative was found to selectively activate transcription factor PPARγ. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Estimated Time of Arrival Using Historical Vessel Tracking Data (2018)

The growing availability of data coming from ship reporting systems, such as Automatic Identification System (AIS) and Long Range Identification and Tracking (LRIT), is originating an unprecedented set of opportunities to enforce maritime surveillance, ensure the security of the traffic at sea, and manage maritime operations. In this paper, a data-driven methodology is proposed to estimate the vessel times of arrival in port areas. The developed approach exploits both AIS and LRIT historical maritime traffic data collected over a desired area of interest and is based on an optimized data-driven path-finding algorithm. The methodology is applied and validated to real scenarios with real data sets, showing how a list of times of arrival can be automatically computed for predefined ports and progressively refined. Such information is expected to increase port operational efficiency and safety.
Characterization of a Yeast Infection in the German Cockroach (Dictyoptera: Blattellidae) (1986)

Journal Article Characterization of a Yeast Infection in the German Cockroach (Dictyoptera: Blattellidae) Get access Edwin F. Archbold, Edwin F. Archbold 1 University of California, Riverside, California 92521 1 Currently on study leave from the Dept. of Microbiology, Loma Linda Univ., Loma Linda, CA 92354. Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael K. Rust, Michael K. Rust 2 University of California, Riverside, California 92521 2 Dept. of Entomology. Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald A. Reierson, Donald A. Reierson 2 University of California, Riverside, California 92521 2 Dept. of Entomology. Search for other works by this author on: Oxford Academic PubMed Google Scholar Katharine D. Atkinson Katharine D. Atkinson 3 University of California, Riverside, California 92521 3 Dept. of Biology. Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 15, Issue 1, 1 February 1986, Pages 221–226, https://doi.org/10.1093/ee/15.1.221 Published: 01 February 1986 Article history Received: 10 May 1985 Accepted: 06 November 1985 Published: 01 February 1986
Plasmacytoid Dendritic Cells Play a Major Role in Apoptotic Leukocyte-Induced Immune Modulation (2011)

Several APCs participate in apoptotic cell-induced immune modulation. Whether plasmacytoid dendritic cells (PDCs) are involved in this process has not yet been characterized. Using a mouse model of allogeneic bone marrow engraftment, we demonstrated that donor bone marrow PDCs are required for both donor apoptotic cell-induced engraftment and regulatory T cell (Treg) increase. We confirmed in naive mice receiving i.v. syngeneic apoptotic cell infusion that PDCs from the spleen induce ex vivo Treg commitment. We showed that PDCs did not interact directly with apoptotic cells. In contrast, in vivo macrophage depletion experiments using clodronate-loaded liposome infusion and coculture experiments with supernatant from macrophages incubated with apoptotic cells showed that PDCs required macrophage-derived soluble factors--including TGF-β--to exert their immunomodulatory functions. Overall, PDCs may be considered as the major APC involved in Treg stimulation/generation in the setting of an immunosuppressive environment obtained by apoptotic cell infusion. These findings show that like other APCs, PDC functions are influenced, at least indirectly, by exposure to blood-borne apoptotic cells. This might correspond with an additional mechanism preventing unwanted immune responses against self-antigens clustered at the cell surface of apoptotic cells occurring during normal cell turnover.
Expression and immunogenicity in rats of recombinant adenovirus 5 DNA plasmids and vaccinia virus containing the HTLV-I-env gene (1997)

The complete human T-cell leukemia virus type I (HTLV-I) env gene was inserted into an expression cassette containing the adenovirus 5 major late promoter (Ad5-MLP). Recombinant Ad5-HTLV-I-env was obtained by homologous recombination in 293 cells simultaneously transfected by the expression cassette and the genomic DNA of Ad5. In vitro expression of the HTLV-I-env gene in the recombinant vector was detected by immunofluorescence and Western blotting. Functional expression of HTLV-I-env was confirmed by syncitium formation specifically in HeLa cells infected with Ad5-HTLV-I-env. Two immunization regimens against HTLV-I were tested in WKY and Fischer F-344 rats. The first involved WKY rats primed with Ad5-HTLV-I-env or naked DNA plasmids containing the HTLV-I-env gene and boosted with Ad5 containing the HTLV-I-env gp46 gene or with baculovirus-derived recombinant gp46. No antibody against HTLV-I was detected, while HTLV-I-specific cytotoxic T lymphocytes were recovered from all immunized groups but not from controls. The second approach involved Fischer F-344 rats primed and boosted with recombinant vaccinia virus containing the HTLV-I-env gene. Such rats developed antibodies against the HTLV-I env gp21 and gp46 (non-neutralizing). After challenge with human HTLV-I-producing cells (MT-2), both immunization regimens were found to induce partial protection.
Toward emergent representations for video (2005)

Advanced systems for finding, using, sharing, and remixing video require high-level representations of video content. A number of researchers have taken top-down, analytic approaches to the specification of representation structures for video. The resulting schemes, while showing the potential of high-level representations for aiding the retrieval and resequencing of video, have generally proved too complex for mainstream use. In this paper, we propose a bottom-up, emergent approach to developing video representation structures by examining retrieval requests and annotations made by a community of video remixers. Our initial research has found a useful degree of convergence between user-generated indexing terms and query terms, with the salient exception of descriptions of characters' corporeal characteristics.
B- Amyloid increases neuronal susceptibility to injufy by glucose deprivation (1991)

Mature cortical cultures, transiently deprived of glucose, developed slight neuronal damage that was exacerbated by exposure to a synthetic analog of the beta-amyloid protein deposited in the neuritic plaques of Alzheimer's disease. The non-competitive N-methyl-D-aspartate antagonist MK801 attenuated the injury-increasing effect of beta-amyloid protein implicating involvement of endogenous excitatory amino acids. These results suggest that beta-amyloid protein may accelerate neuronal degeneration in the presence of defective cerebral glucose metabolism which has been reported to occur in Alzheimer's disease.
Diacylglycerol Oil (2004)

Useful to nutritionists, physicians, and public health professionals as well as food scientists and technologists, and process engineers, this book reviews the metabolism and health benefits as well as international safety and regulatory information of diacylglycerol oils. The book contains long-term clinical studies diacylglycerols' effects on ene
A Lipopolysaccharide Mutant of<i>Bradyrhizobium japonicum</i>that Uncouples Plant from Bacterial Differentiation (1991)

The Tn5-containing fragment from a non-nodulating mutant of Bradyrhizobium japonicum, strain ML142, was introduced into B. japonicum strain 61A101c by marker exchange to construct strain JS314. Strain JS314 failed to nodulate several soybean varieties tested. However, on a few varieties nodulelike structures were induced to a frequency of 54% of the plants inoculated. The ultrastructure of these nodules was studied in detail by light and electron microscopy. The nodules were devoid of internal bacteria, possessed central vascular tissue (unlike the lateral vascular tissue of a normal nodule), and exhibited localized cell death of epidermal cells. Study of the cell surface polysaccharides of strain JS314 revealed that the exopolysaccharide of this strain was identical to that of the wild type. However, the lipopolysaccharide (LPS) of strain JS314 showed gross differences from that isolated from the wild-type strain. Specifically, the LPS of strain JS314 appeared to lack the high molecular weight LPS I form, strongly suggesting that the LPS lacks the O-chain. Glycosyl-composition analysis showed that the LPS of mutant JS314 lacked 2,3-di-O-methylrhamnose, 3-O-methylrhamnose, fucose, and quinovosamine. These results indicate that LPS I in B. japonicum is essential for bacterial infection of soybean, but is not required to initiate plant cortical cell division, an early plant response to infection.
Characterisation of stress protein LysU. Enzymic synthesis of diadenosine 5′,5‴-P<sup>1</sup>,P<sup>4</sup>-tetraphosphate (Ap<sub>4</sub>A) analogues by LysU (1996)

The stress protein LysU (lysyl tRNA synthetase) has been purified from a recombinant strain of Escherichia coli expressing the plasmid pXLys5, and kinetically characterised. Preparative syntheses of analogues of the biologically important molecule diadenosine 5′,5‴-P1,P4-tetraphosphate (Ap4A) are then achieved in good yield by enzyme catalysis, using purified LysU.
Reactions of Zirconacyclopentadienes with Nitrosobenzene. Characterization of Zirconacycle Intermediates and Formation of <i>N</i>-Phenylpyrroles (2001)

Nitrosobenzene inserts into the Zr−C bond of zirconacyclopentadienes to give seven-membered zirconacyclic rings. The resulting insertion products are readily converted to N-phenylpyrroles and (in one case) a 3,3-spiroindole derivative.
Lung impedance in healthy humans measured by forced oscillations from 0.01 to 0.1 Hz (1989)

Lung impedance was measured from 0.01 to 0.1 Hz in six healthy adults by superimposing small-amplitude forced oscillations on spontaneous breathing. Measurements were made with an almost constant-volume input (160-180 ml) or with an almost constant-flow input (20-30 ml.s-1). No significant difference was found between the two conditions. Lung resistance (RL) sharply decreased from 0.97 kPa.l-1.s at 0.01 Hz to 0.27 kPa.l-1.s at 0.03 Hz and then mildly to 0.23 kPa.l-1.s at 0.1 Hz. Lung effective compliance (CL) decreased slightly and regularly from 0.01 Hz (2.38 l.kPa-1) to 0.1 Hz (1.93 l.kPa-1). The data were analyzed using a linear viscoelastic model adapted from Hildebrandt (J. Appl. Physiol. 28:365-372, 1970) and complemented by a Newtonian resistance (R): RL = R + B/(9.2f); CL = 1/(A + 0.25B + B.log2 pi f), where f is the frequency and B/A is an index of lung tissue viscoelasticity. A good fit was generally obtained, with an average difference of 10% between the observed and predicted values. The ratio B/A was not affected by the breathing and was 10.6 and 13.6% in the constant-volume and constant-flow conditions, respectively, which agrees with Hildebrandt's observations in isolated cat lungs. R was systematically larger than the plethysmographic airway resistance, suggesting that lung tissue resistance might also include a Newtonian component.
Clicking DNA to gold nanoparticles: poly-adenine-mediated formation of monovalent DNA-gold nanoparticle conjugates with nearly quantitative yield (2015)

Monovalent DNA–gold nanoparticle (mDNA–AuNP) conjugates hold great promise for widespread applications, especially the construction of well-defined, molecule-like nanosystems. Previously reported methods all rely on the use of thiolated DNA to functionalize AuNPs, resulting in relatively low yields. Here, we report a facile method to rapidly prepare mDNA–AuNPs using a poly-adenine (polyA)-mediated approach. As polyA can selectively bind to AuNPs with high controllability of the surface density of DNA, we can use a DNA strand with a sufficiently long polyA to wrap around the surface of an individual AuNP, preventing further the adsorption of additional strands. Based on this observation, we obtained mDNA–AuNPs with a nearly quantitative yield of ~90% using 80 As, as confirmed by both gel electrophoresis and transmission electron microscope observation. The yields of mDNA–AuNPs were insensitive to the stoichiometric ratio between DNA and AuNPs, suggesting the click chemistry-like nature of this polyA-mediated reaction. mDNA–AuNPs exhibited rapid kinetics and high efficiency for sequence-specific hybridization. More importantly, we demonstrated that AuNPs of fixed valences could form well-defined heterogenous oligomeric nanostructures with precise, atom-like control. An easy, one-step, high-yield (~90%) way of preparing gold nanoparticles functionalized with monovalent DNA is reported by a team in China. Monovalent DNA–gold nanoparticle conjugates have many uses, such as acting as building blocks for the bottom-up construction of nanosystems. Common synthesis methods, however, use thiolated DNA and suffer from low yields. The method reported here, which was developed by researchers at Sichuan University and the Chinese Academy of Sciences, employs a new strategy that uses polyadenine to mediate the functionalization of gold nanoparticles. It involves wrapping the surfaces of the gold nanoparticles with DNA strands attached to sufficiently long lengths of polyadenine, which prevents additional DNA strands being adsorbed. The researchers show the potential of their method by using gold nanoparticles of fixed valences to form oligomeric nanostructures with precise, atom-level control. PolyA can selectively bind to AuNPs with similar affinity to thiolated DNA and better control of the surface density of DNA, which results in the formation of monovalent DNA-gold nanoparticle conjugates . mDNA–AuNPs with in a click chemistry-like manner.