gebhart/patrepeval huggingface dataset:
A two-photon “turn-on” fluorescent probe based on carbon nanodots for imaging and selective biosensing of hydrogen sulfide in live cells and tissues (2014)

Determination of hydrogen sulfide (H2S) in live cells and tissues is still a challenge for evaluating the key roles that H2S plays in physiological and pathological processes. In this work, a "turn-on" two-photon fluorescent (TPF) sensor for H2S is developed, in which carbon nanodot (C-Dot) was employed as a two-photon fluorophore due to its large two-photon absorption cross-section (σ), and AE-TPEA-Cu(2+) complex [AE-TPEA = N-(2-aminoethyl)-N,N,N'-tris(pyridin-2-ylmethyl)ethane-1,2-diamine] was first designed as a specific receptor for H2S. The fluorescence of C-Dot conjugated with AE-TPEA (C-Dot-TPEA) was quenched upon the addition of Cu(2+). Then, the fluorescence was restored after the addition of H2S, because Cu(2+) could be released from TPEA binding site when H2S interacted with the Cu(2+) ion. The designed C-Dot-TPEA-Cu(2+) fluorescent sensor exhibited high specificity for H2S over biothiols, sulfur-containing compounds, reactive oxygen species (ROS), and other biological interferences. Meanwhile, a broad linear range from 5 μM to 100 μM was obtained and the detection limit was achieved to 0.7 μM. In addition, the C-Dot-based TPF probe exhibited bright two-photon fluorescence, favourable photostability against light illumination and pH change, and low cytotoxicity. Accordingly, the nanohybridized TPF sensor with high selectivity and sensitivity, as well as the fascinating properties of C-Dot themselves, successfully provided a new way for TPF imaging and biosensing of H2S in live cells and tissues. We believe this is the first report of TPF imaging and biosensing of H2S in live cells and tissues using a specially engineered C-Dot-based nanosystem.
Effect of Intravenous Nimodipine on Blood Pressure and Outcome After Acute Stroke (2000)

DBP, but not SBP, reduction was associated with neurological worsening after the intravenous administration of high-dose nimodipine after acute stroke. For low-dose nimodipine, the results were not conclusive. These results do not confirm or exclude a neuroprotective property of nimodipine.
FRD-CNN: Object detection based on small-scale convolutional neural networks and feature reuse (2019)

Most of the recent successful object detection methods have been based on convolutional neural networks (CNNs). From previous studies, we learned that many feature reuse methods improve the network performance, but they increase the number of parameters. DenseNet uses thin layers that have fewer channels to alleviate the increase in parameters. This motivated us to find other methods for solving the increase in model size problems introduced by feature reuse methods. In this work, we employ different feature reuse methods on fire units and mobile units. We solved the problem and constructed two novel neural networks, fire-FRD-CNN and mobile-FRD-CNN. We conducted experiments with the proposed neural networks on KITTI and PASCAL VOC datasets.
New Rectangular Finite Element for Shear Wall Analysis (1969)

Most previously derived plane stress finite elements cannot be connected with line elements in bending. This difficulty is overcome by devising a new element which has rotational degrees of freedom at the node points. Application to analysis of simple shear wall problems with a single row of openings illustrates the method and comparison of results with other solutions demonstrates its validity. A study of the behavior of the new element in comparison with results for a more conventional element shows: (1) For the same number of elements, the accuracy of estimation of deflection is increased and (2) the ratio of length to breadth of the elements has a less significant effect on the results.
A Software-Defined Device-to-Device Communication Architecture for Public Safety Applications in 5G Networks (2015)

The device-to-device (D2D) communication paradigm in 5G networks provides an effective infrastructure to enable different smart city applications such as public safety. In future smart cities, dense deployment of wireless sensor networks (WSNs) can be integrated with 5G networks using D2D communication. D2D communication enables direct communication between nearby user equipments (UEs) using cellular or ad hoc links, thereby improving the spectrum utilization, system throughput, and energy efficiency of the network. In this paper, we propose a hierarchal D2D communication architecture where a centralized software-defined network (SDN) controller communicates with the cloud head to reduce the number of requested long-term evolution (LTE) communication links, thereby improving energy consumption. The concept of local and central controller enables our architecture to work in case of infrastructure damage and hotspot traffic situation. The architecture helps to maintain the communication between disaster victims and first responders by installing multi-hop routing path with the support of the SDN controller. In addition, we highlight the robustness and potential of our architecture by presenting a public safety scenario, where a part of the network is offline due to extraordinary events such as disaster or terrorist attacks.
Simulation study of a waveguide power combining network (2013)

A waveguide based four way millimeter-wave power combining network is studied using HFSS in this paper. The power combining network is composed of a power divider sub-network, four metal PCB cavities and a power combiner sub-network. A compact waveguide directional coupler is designed to act as the power combiner and power divider. Parameters and shapes of the PCB cavities are carefully studied to avoid the resonant modes of the cavities, and a rhombus-like PCB cavity which has good transmission coefficient is presented.
How I treat relapsed and refractory Hodgkin lymphoma (2011)

Relapsed or refractory Hodgkin lymphoma is a challenging problem for clinicians who treat hematologic malignancies. The standard management of these patients should include the use of salvage chemotherapy followed by autologous stem cell transplant (ASCT) in patients who are chemotherapy sensitive. Open issues in this area include the role of functional imaging, the specific chemotherapy regimen to be used before ASCT, and the role of consolidative radiotherapy. Some patients will not be eligible for ASCT, and alternative approaches with conventional chemotherapy alone or with salvage radiotherapy should be considered. Prognostic factors for relapsed/refractory disease have been identified but generally are not used as a part of risk-adapted therapy. Allogeneic transplantation may offer the potential of a graft-versus-lymphoma effect, but this therapy has significant toxicity and results in few long-term disease-free survivors; hence, it should only be offered in the context of disease-specific clinical trials. An expanding list of novel drugs has exhibited promising single-agent activity. Patients have effective options beyond primary therapy, and continued progress through controlled trials remains a tangible goal in the treatment of relapsed and refractory disease.
Bridgehead-Substituted Triptycenes for Discovery of Nucleic Acid Junction Binders (2016)

Recently, the utility of triptycene as a scaffold for targeting nucleic acid three-way junctions was demonstrated. A rapid, efficient route for the synthesis of bridgehead-substituted triptycenes is reported, in addition to solid-phase diversification to a new class of triptycene peptides. The triptycene peptides were evaluated for binding to a d(CAG)·(CTG) repeat DNA junction exhibiting potent affinities. The bridgehead-substituted triptycenes provide new building blocks for rapid access to diverse triptycene ligands with novel architectures.
Changes of respiratory input impedance during breathing in humans (1992)

Changes of total respiratory resistance (Rrs) and reactance (Xrs) were studied between 8 and 32 Hz at five moments during the respiratory cycle in healthy adults (group A) and children (group B) and in patients with chronic obstructive lung disease (group C) and with upper airway obstruction (group D). Two forced oscillation techniques were used: the conventional one and the head generator, with the oscillations applied at the mouth and around the head of the subject, respectively. Both techniques yielded similar results. Rrs is lowest during the transition from inspiration to expiration and highest in the course of expiration, except in group D. Mean Xrs is highest at the transitions from inspiration to expiration or vice versa and lowest during expiration, except in group D. In groups C and D, the increases of Rrs are accompanied by a more pronounced negative frequency dependence of Rrs. The variations of Rrs and Xrs appear to be markedly flow dependent and may be a consequence of the interaction of breathing with oscillatory flows.
THE ROLE OF MODEL SELECTION IN CAUSAL INFERENCE FROM NONEXPERIMENTAL DATA (1986)

Journal Article THE ROLE OF MODEL SELECTION IN CAUSAL INFERENCE FROM NONEXPERIMENTAL DATA Get access JAMES M. ROBINS, JAMES M. ROBINS 1Occupational Health Program, Harvard School of Public Health665 Huntington Ave., Boston, MA 02115 Send requests for reprints to Dr. James M. Robins at this address. Search for other works by this author on: Oxford Academic PubMed Google Scholar SANDER GREENLAND SANDER GREENLAND 2Division of Epidemiology, UCLA School of Public HealthLos Angeles CA Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 123, Issue 3, March 1986, Pages 392–402, https://doi.org/10.1093/oxfordjournals.aje.a114254 Published: 01 March 1986
Need Stress Relief? A New Approach to Reducing Stress Cycling Induced Proppant Pack Failure (1998)

Abstract Stress cycling of proppant packs often occurs during well production operations and is known to be a major contributing factor to proppant pack failure. Proppant crushing occurs due to increasing closure stress as a well is drawn down. The fines generated by such crushing can cause significant damage to proppant pack porosity and fracture conductivity. Additionally, the incidence of proppant flowback (fines and whole proppant) has been reported to be exacerbated by stress cycling. The addition of deformable beads to the proppant pack has been observed to alleviate both problems and may significantly improve well performance. Testing of various mixtures of the deformable beads and proppant has demonstrated significant reductions in the amount of fines generated and accompanying improvements in proppant pack permeability. Furthermore, the initiation of proppant flowback was observed to require much higher flow rates than in the absence of the beads. It is thought the process of bead deformation serves to "cushion" the proppant particles from the full brunt of the stress. New laboratory facilities and procedures have been established to study and quantify, proppant flowback, and conductivity as a function of proppant, temperature, flow rate. fracture width, closure stress, and cycle frequency. P. 659
Cycloheximide Sensitivity as a Taxonomic Character in <i>Ceratocystis</i> (1981)

SUMMARYThe effect of 100 ppm cycloheximide on the linear growth of 53 species of Ceratocystis sensu amplo and related fungi was determined on malt extract agar at 25 C. Generally, only those species with Chalara-like anamorphs (Ceratocystis sensu strıcto) were inhibited by 100 ppm cycloheximide. Growth of other Ceratocystis species (Ophiostoma sensu von Arx), Europhium spp., and related anamorphs was generally unaffected by cycloheximide.
Capacitive charge division readout of a double-sided germanium strip detector (1995)

We have implemented a capacitive charge-division readout for a germanium 5/spl times/5 orthogonal strip detector. We present measurements of non-linearity, and of energy and position resolution as a function of energy (60 and 662 keV) and of network capacitance. Energy and position non-linearities, which are worse for low capacitance networks, appear in the response along the charge division network, as well as along the length of each detector strip. The nonlinearities can be corrected by using an independent gain calibration for each pixel, allowing for use of a lower capacitance charge division network which provides better position resolution.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Comparison of Different Surface Strain Measurement Methods Used for Deformed Sheet Metal Parts (1992)

<div class="htmlview paragraph">A recently developed automated method for measuring surface strains on a deformed three dimensional part is compared with a careful manual measurement method and the differences are discussed. The overall experimental procedure consisted of marking the sheet steel surface with square grids, forming them into different shapes, and measuring surface strains by the two different methods. The manual method involved measuring the distances in each square using a traveling microscope. The automated method is based on digital image processing techniques and is capable of measuring strain distributions over an area of interest. The measured results from both methods agree reasonably well, but some discrepancies are observed at locations where strains are localized.</div>
Metal Nanoparticles with a Knack for Molecular Recognition (2000)

Cyclodextrin-modified metal nanoparticles illustrate the role that protective organic shells can play in the modulation of the properties of nanoparticles, endowing them with molecular recognition abilities, as highlighted here. These nanocomposite materials are of fundamental interest for the organized self-assembly of metal nanoparticles.
Model-Based Engineering of Embedded Control Software (2006)

In the domain of embedded software systems, two different modeling paradigms are common: data flow-oriented approaches as used in control engineering, and interaction-oriented approaches as used in software engineering. While the former are traditionally applied to describe complex algorithms to control (physical) processes, the latter are generally applied to describe complex interaction patterns influenced by operation modes. As current embedded systems increasingly require a combination of both aspects, an integrated modeling paradigm is introduced to support a homogeneous development process covering both aspects
Pegylated Interferon α Therapy in Chronic Delta Hepatitis: A One-Center Experience (2015)

Treatment with Peg IFN α achieved a sustained negativity of HDV RNA in about one third of patients. Duration of Peg IFN α therapy might be prolonged to at least 24 months or more to prevent the occurrence of Hepatitis B virus (HBV) relapse encountered six months after completion of the treatment.
Real-time SAW measurements of NVR in cleanroom and in microenvironment (1994)

Using a real-time, Surface Acoustic Wave (SAW) sensing instrument supplied by Femtometrics, we have measured organic contamination, or nonvolatile residues (NVR), in both a cleanroom and a microenvironment. To demonstrate the {open_quotes}real-time{close_quotes} NVR detectability and sensitivity of the SAW instrument, controlled contamination experiments with photoresist material were also conducted. In addition, two cleaning methods for removing contamination from used sensors have been evaluated. One technique uses the on-board temperature varying capability of the SAW instrument, while the other technique utilizes a uv-ozone cleaner for the sensor cleaning. Preliminary results from SAW measurements in the cleanroom and in a microenvironment and tests to evaluate sensor cleaning techniques are presented in this report. A concluding summary with an assessment of the current SAW instrument and potential future applications for this technology is also presented.
Evidence for Penetration in Liposomes and in Mitochondrial Membranes of a Fluorescent Analogue of Cord Factor (1980)

A fluorescent analogue of cord factor, a glycolipid toxin of mycobacteria, has been synthesized and its interactions with liposomes and isolated mitochondria have been studied. This compound, methyl alpha-D-6[12-(9-anthroyl)stearoyl]glucoside, is shown to be active against oxidative phosphorylation. When spread as a monolayer at the air-water interface, it forms a well organized phase and it strongly interacts with phosphatidylcholine. Addition of phosphatidylcholine liposomes or of isolated mitochondria to a water disperson of this fluorescent cord factor analogue results in a large increase of the fluorescence intensity. Moreover, the glycolipid probes for the temperature-dependent phase transition of the added suspensions. It is thus suggested that this cord factor analogue penetrates within mitochondrial membranes, a result which is discussed with respect to our previous conclusions concerning the way natural cord factors can interact with these organelles.
Epigenetic Regulation of Learning and Memory by Drosophila EHMT/G9a (2011)

The epigenetic modification of chromatin structure and its effect on complex neuronal processes like learning and memory is an emerging field in neuroscience. However, little is known about the "writers" of the neuronal epigenome and how they lay down the basis for proper cognition. Here, we have dissected the neuronal function of the Drosophila euchromatin histone methyltransferase (EHMT), a member of a conserved protein family that methylates histone 3 at lysine 9 (H3K9). EHMT is widely expressed in the nervous system and other tissues, yet EHMT mutant flies are viable. Neurodevelopmental and behavioral analyses identified EHMT as a regulator of peripheral dendrite development, larval locomotor behavior, non-associative learning, and courtship memory. The requirement for EHMT in memory was mapped to 7B-Gal4 positive cells, which are, in adult brains, predominantly mushroom body neurons. Moreover, memory was restored by EHMT re-expression during adulthood, indicating that cognitive defects are reversible in EHMT mutants. To uncover the underlying molecular mechanisms, we generated genome-wide H3K9 dimethylation profiles by ChIP-seq. Loss of H3K9 dimethylation in EHMT mutants occurs at 5% of the euchromatic genome and is enriched at the 5' and 3' ends of distinct classes of genes that control neuronal and behavioral processes that are corrupted in EHMT mutants. Our study identifies Drosophila EHMT as a key regulator of cognition that orchestrates an epigenetic program featuring classic learning and memory genes. Our findings are relevant to the pathophysiological mechanisms underlying Kleefstra Syndrome, a severe form of intellectual disability caused by mutations in human EHMT1, and have potential therapeutic implications. Our work thus provides novel insights into the epigenetic control of cognition in health and disease.
PMD-Induced Fluctuations of Bit-Error Rate in Optical Fiber Systems (2004)

This paper presents a method that allows evaluating the performance of an optical fiber system where bit errors result from a complex interplay of spontaneous noise generated in optical amplifiers and birefringent disorder of the transmission fiber. We demonstrate that in the presence of temporal fluctuations of birefringence characteristics, the bit-error rate (BER) itself is insufficient for characterizing system performance. Adequate characterization requires introducing the probability distribution function (PDF) of the BER obtained by averaging over many realizations of birefringent disorder. Our theoretical analysis shows that this PDF has an extended tail indicating the importance of anomalously large values of BER. We present the results of comprehensive analysis of the following issues: 1) The dependence of the PDF tail shape on detection details, such as filtering and regular temporal shift adjustment; 2) the changes in the PDF of BER that occur when the first- or higher order polarization mode dispersion (PMD) compensation techniques are applied; 3) an alternative PMD compensation method capable of providing more efficient suppression of extreme outages.
Influenza virus hemagglutinin as a vaccine antigen produced in bacteria. (2014)

Recombinant subunit vaccines based on hemagglutinin proteins produced in bacteria (bacterial HAs) are promising candidates for enhancing the supply of vaccines against influenza, especially for a pandemic. Over 20 years after the failure to obtain the antigen with native HA characteristics in the early 1980's, there are increasing data on successful production of HA proteins in bacteria. The vast majority of bacterial HAs have been based on the HA1 subunit of HA expressed separately or as a component of conjugate vaccines, but those based on the ectodomain and the HA2 subunit have also been reported. The most of HAs have been efficiently expressed as insoluble aggregates called inclusion bodies. Refolded and purified proteins were extensively studied for structure, the ability to bind to sialic acid-containing receptors, antigenicity, immunogenicity and efficacy. The results from these studies contradict the view that glycosylation determines the correct structure of the hemagglutinin, as they proved that bacterial HAs can be valuable vaccine antigens when appropriate folding and purification methods are applied to rationally designed proteins. The best evidence for success in bacterial production of protective HA is that vaccines based on proprietary Toll-like Receptor (VaxInnate) and bacteriophage Qβ-VLPs (Cytos Biotechnology) technologies have been advanced to clinical studies.
Circularly polarized 2450‐MHz waveguide system for chronic exposure of small animals to microwaves (1979)

A system developed to expose chronically a large number of small animals to 918‐MHz microwave has been modified to permit exposure at 2450 MHz. Special transmitting and termination transducers were used to retrofit the exposure chambers of the 918‐MHz system. The use of separate cells that consist of cylindrical waveguides, which are excited by circularly polarized, guided waves, provides a relatively constant and easily quantifiable coupling of microwave energy to each animal, regardless of their position, posture, or movement. The VSWR in each cell is sufficiently low that any number of cells can be coupled to a single source through a power splitter without the need for an isolator.
Ultra-fast CELP coding using deterministic multi-codebook innovations (1992)

The authors describe improvements to the code excited linear prediction (CELP) excitation model for speech coding at 4 kb/s or less. The innovation signal in the coder is modeled using a multisection codebook of deterministic code sequences. These deterministic code sequences not only improve the subjective voice quality of CELP coder at low bit rates, they also significantly reduce the computational complexity of the coder. These advantages make the coder attractive for application in the newly emerging wireless communication environment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Role of Gamma Interferon in Controlling Murine Chlamydial Genital Tract Infection (1999)

Earlier investigations have not shown an important role for gamma interferon (IFN-gamma) in the early clearance of chlamydial infection from the murine female genital tract. In a model using a human genital isolate of Chlamydia trachomatis in IFN-gamma and IFN-gamma receptor knockout mice, we were able to demonstrate a major role for IFN-gamma in mediating control of infection throughout the course of infection.