gebhart/patrepeval huggingface dataset:
Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma (1999)

We studied the involvement of PRIM1 in osteosarcoma by differential display, Northern and Southern hybridization, as well as fluorescence in situ hybridization (FISH) on interphase nuclei. In total, 22 pediatric oncology specimens were tested. PRIM1 was found to be amplified in 41% of the samples. PRIM1 is coamplified with the core 12q13 amplicon genes CDK4, SAS, and OS9, and was physically mapped very close to them. PRIM1 is therefore a new candidate for the role of a major target gene of 12q13 amplifications in human cancers. Genes Chromosomes Cancer 26:62-69, 1999.
Relationship between d-Dimensional Quantal Spin Systems and (d+1)-Dimensional Ising Systems: Equivalence, Critical Exponents and Systematic Approximants of the Partition Function and Spin Correlations (1976)

The partition function of a quantal spin system is expressed by that of the Ising model, on the basis of the generalized Trotter formula. Thereby the ground state of the d-dimensional Ising model with a transverse field is proven to be equivalent to the (d+1)-dimensional Ising model at finite temperatures. A general relationship is established between the two partition functions of a general quantal spin system and the corresponding Ising model with many-spin interactions, which yields some rigorous results on quantum systems. Some applications are given.
Protective Effects of Polyclonal Sera and of Monoclonal Antibodies Active to Salmonella minnesota Re595 Lipopolysaccharide during Experimental Endotoxemia (1990)

Mice were passively immunized with sera from blood donors active for rough lipopolysaccharides (LPS), the J5 (Rc chemotype) mutant of Escherichia coli O111:B4, and the Re595 (Re chemotype) mutant of Salmonella minnesota. All protected the mice against lethal challenge with smooth E. coli WF96 LPS, E. coli and Salmonella rough mutant LPS, or free lipid A. Epitopes recognized by monoclonal antibodies (MAbs) reacting with the LPS of S. minnesota Re595 or lipid A were localized in the 2-keto-3-deoxy-D-manno-octulosonic acid (KDO) region and on lipid A. Core-reactive MAbs reacted with their homologous Re LPS and with free lipid A. One, GL11, cross-reacted with the KDO alone. MAbs GL6, GL11, L.4, L.6, and L.8 protected the actinomycin D-sensitized mice against the lethal effects of LPS from E. coli WF96, Salmonella enteritidis, E. coli J5, S. minnesota Re595, and free lipid A. The GL11 antibody was also protective when injected after LPS challenge. These results indicate that antibodies directed against the core glycolipid of S. minnesota Re595 LPS may be useful as an additive form of therapy that may enable decreased mortality during gram-negative bacterial sepsis.
Rapid prototyping of transition management code for reconfigurable control systems (2003)

This paper presents a rapid prototyping technique that focuses on transition management in hybrid systems. In particular, it integrates hybrid modeling and simulation (for specifying and validating transition strategies) with a generic transition management pattern built on a Real-Time CORBA-based platform for reconfigurable control systems. Code generation is performed from the hybrid models to transition management code. This allows hybrid systems and their reconfiguration strategies to be prototyped and validated at an early stage in development and for the strategies to be directly transferred into the control system software without a separate, manual reimplementation step. The application of this work is found in most complex control systems, including the control of unmanned aerial vehicle (UAVs) performing extreme maneuvers, which is our driving application area.
Ketamine‐inhibition of calcium‐induced contractions in depolarized rat uterus: a comparison with other calcium antagonists (1985)

The inhibitory effect of the intravenous anaesthetic ketamine on CaCl2-induced contractions in the isolated K+-depolarized uterus of the rat in Ca2+-free medium was compared with that produced by papaverine, theophylline and the calcium entry blocker verapamil. Pre-incubation for 20 min with either ketamine (0.3 to 3 mM), papaverine (3 to 30 microM), theophylline (0.1 to 1 mM) or verapamil (3 to 30 nM) induced parallel, concentration-dependent rightward displacements of the dose-response curves to Ca2+ (0.04 to 22 mM). The antagonism was competitive, except that due to verapamil, the Schild plot for which yielded a slope which differed significantly from unity. The calculated pA2 values (+/- s.e.mean) were: ketamine 3.90 +/- 0.07; papaverine 5.55 +/- 0.05; theophylline 3.99 +/- 0.1 and verapamil 9.54 +/- 0.24. These drugs differed in their ability to relax the sustained contraction induced by Ca2+ (1 mM) in K+-depolarizing solution. Ketamine and verapamil relaxed the preparation in a concentration-dependent manner whereas theophylline and especially papaverine were less potent and induced only partial maximal relaxation. The t1/2 of the relaxant effect was significantly less for ketamine than for verapamil (5 and 22 min, respectively). Only ketamine produced a relaxation comparable to that obtained by washing the preparation with Ca2+-free solution (t1/2 = approx. 5 min). Prior exposure of the depolarized uterine strip to a low concentration of Ca2+ (0.22 mM) increased the potency of ketamine, but decreased that of papaverine and theophylline, in antagonizing Ca2+ induced contractions. In contrast, this procedure did not affect the potency of verapamil. 5 The inhibitory effects of these drugs, excluding those of verapamil, were completely reversed after washing the preparations with a high-potassium Ca2+-free solution, 3-5 times for about 30-60 min. 6 These experiments provide further evidence that the relaxant effect produced by ketamine on the rat isolated uterus is due to its ability to antagonize Ca2+ movements competitively and also show that there are marked differences between the nature of the relaxant effects of ketamine and those of papaverine, theophylline and verapamil.
Particle Swarm Optimization for Feature Selection in Classification: A Multi-Objective Approach (2012)

Classification problems often have a large number of features in the data sets, but not all of them are useful for classification. Irrelevant and redundant features may even reduce the performance. Feature selection aims to choose a small number of relevant features to achieve similar or even better classification performance than using all features. It has two main conflicting objectives of maximizing the classification performance and minimizing the number of features. However, most existing feature selection algorithms treat the task as a single objective problem. This paper presents the first study on multi-objective particle swarm optimization (PSO) for feature selection. The task is to generate a Pareto front of nondominated solutions (feature subsets). We investigate two PSO-based multi-objective feature selection algorithms. The first algorithm introduces the idea of nondominated sorting into PSO to address feature selection problems. The second algorithm applies the ideas of crowding, mutation, and dominance to PSO to search for the Pareto front solutions. The two multi-objective algorithms are compared with two conventional feature selection methods, a single objective feature selection method, a two-stage feature selection algorithm, and three well-known evolutionary multi-objective algorithms on 12 benchmark data sets. The experimental results show that the two PSO-based multi-objective algorithms can automatically evolve a set of nondominated solutions. The first algorithm outperforms the two conventional methods, the single objective method, and the two-stage algorithm. It achieves comparable results with the existing three well-known multi-objective algorithms in most cases. The second algorithm achieves better results than the first algorithm and all other methods mentioned previously.
Mesopic color appearance (2003)

Experiments were conducted to investigate colour appearance under mesopic vision. Lightness, colourfulness and hue observations of 40 test colours were accumulated for eight phases with four different luminance levels covering 0.1 to 90 cd/m<sup>2</sup> and two different stimulus sizes corresponding to viewing angles of 2° and 10° using the magnitude estimation method. The psychophysical effects of luminance level and patch size on colour appearance were investigated and the role of the rods under mesopic vision was explored.
An Identity-Based Authentication Model for Mobile Agent (2009)

Mobile agent and its security are first introduced in this paper. Fundamental to the mentioned communication security properties are issues relating to the identification and authentication of sending and receiving parties. A security authentication scheme for mobile agent of multi domain is provided and a detail description is given in the paper. The scheme is based on identity-based public key cryptography, so as to overcome some shortage posed by traditional authentication model based on PKI. The security of the scheme is also analyzed and it shows that the proposed scheme is secure and effective.
Tyr612 and Tyr632 in Human Insulin Receptor Substrate-1 Are Important for Full Activation of Insulin-Stimulated Phosphatidylinositol 3-Kinase Activity and Translocation of GLUT4 in Adipose Cells* (2001)

To examine contributions of specific YXXM motifs in human insulin receptor substrate-1 (IRS-1) to mediating the metabolic actions of insulin, we studied IRS-1 mutants containing various substitutions of Phe for Tyr. In transfected NIH-3T3(IR) cells, insulin stimulation caused a 5-fold increase in phosphatidylinositol 3-kinase (PI3K) activity coimmunoprecipitated with wild-type IRS-1. No PI3K activity was associated with IRS1-F6 (Phe substituted for Tyr at positions 465, 612, 632, 662, 941, and 989). Adding back both Tyr(612) and Tyr(632) fully restored IRS-1-associated PI3K activity, whereas adding back either Tyr(612) or Tyr(632) alone was associated with intermediate PI3K activity. In rat adipose cells transfected with epitope-tagged GLUT4, insulin stimulation caused a 2-fold increase in cell surface GLUT4-HA. Cotransfection of cells with GLUT4-HA and either wild-type IRS-1 or IRS1-Y612/Y632 increased basal cell surface GLUT4-HA (in the absence of insulin) to approximately 80% of the levels seen in insulin-stimulated control cells, whereas overexpression of IRS1-F6 had no effect on the insulin dose-response curve. Overexpression of IRS1-Y612 or IRS1-Y632 caused intermediate effects. Thus, both Tyr(612) and Tyr(632) are important for IRS-1 to fully activate PI3K and mediate translocation of GLUT4 in response to insulin.
Experimental Analysis of Model-Based Predictive Optimal Control for Active and Passive Building Thermal Storage Inventory (2005)

Abstract This paper demonstrates model-based predictive optimal control of active and passive building thermal storage inventory in a test facility in real time using time-of-use differentiated electricity prices without demand charges. A novel supervisory controller successfully executed a three-step procedure consisting of (1) short-term weather prediction, (2) optimization of control strategy over the next planning horizon using a calibrated building model, and (3) post-processing of the optimal strategy to yield a control command for the current time step that can be executed in the test facility. All primary and secondary building mechanical systems were effectively orchestrated by the model-based predictive optimal controller in real time while observing comfort and operational constraints. It was determined that even when the optimal controller is given imperfect weather forecasts and when the building model used for planning control strategies does not match the actual building perfectly, measured utility cost savings relative to conventional building operation can be substantial. Central requirements are a facility that lends itself to passive storage utilization and a building model that includes a realistic plant representation. Savings associated with passive building thermal storage inventory proved to be small in this case because the test facility is not an ideal candidate for the investigated control technology. Moreover, the facility's central plant revealed the idiosyncratic behavior that the chiller operation in the ice-making mode was more energy efficient than in the chilled-water mode. Field experimentation is now required in a suitable commercial building with sufficient thermal mass, an active TES system, and a climate conducive to passive storage utilization over a longer testing period to support the laboratory findings presented in this study.
Connectors in Software Architectures (2002)

Nowadays, to allow for rapid software evolution, more and more software developers are starting to construct their products from reusable software components. In this approach, the architecture of a system is described as a collection of components along with the interactions among those components. Even though the main building blocks of the system are components, the properties of the system also strongly depend on the character of the component interactions. This fact gave birth to a “connector ” as an abstraction capturing the nature of these interactions. Even though the notion of connectors originates in the earliest papers on software architectures [54, 47], connectors are currently far from being a typical first class entity in contemporary component-based systems. The main problem of current component-based systems and their respective ADLs is that they either do not capture component interactions at all, or that they only focus on application design stages. By articulating the problem of deployment anomaly, this thesis identifies a role that connectors should play when the distribution and deployment of a component-based application are considered. As none of the related component-based systems does so, a new connector model that allows a variety of (possibly complex) component interactions to be reflected at all the key stages of an application lifecycle (ADL specification, implementation, deployment, and runtime) is further introduced.
Aminoguanidine Derivatives (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAminoguanidine DerivativesVera A. Conard and R. L. ShrinerCite this: J. Am. Chem. Soc. 1933, 55, 7, 2867–2870Publication Date (Print):July 1, 1933Publication History Published online1 May 2002Published inissue 1 July 1933https://pubs.acs.org/doi/10.1021/ja01334a039https://doi.org/10.1021/ja01334a039research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimal Selection of Feedback Control Parameters (1992)

Feedback controllers are widely used in industrial applications. The controller parameters are normally found using heuristic methods such as Ziegler-Nichols tuning rule. In this paper, we consider a class of optimal control problem involving PI or PID feedback controllers. Our aim is to propose an alternative and effective method to compute controller parameters so that the integral square error in the set-point response of the controlled system is minimized subject to practical constraints relating to stability, oscillation and overshooting. In the proposed method, we formulate the problem as an optimal parameter selection problem in which these controller parameters are to be chosen optimally. The problem can then be solved using optimal control software MISER3. This method offers an alternative approach to PI and PID feedback controller coefficients tuning. For illustration, two examples are solved using the proposed method. Results are then compared with those obtained using the heuristic tuning methods.
THE (C-H) BOND DISSOCIATION ENERGY IN THE METHYL GROUP OF TOLUENE (1956)

A kinetic study of the pyrolysis of toluene by a flow technique has been made, and assuming Szwarc's mechanism, two activation energies (78.3 and 84 kcal/ mole depending on the temperature range used) have been derived for the dissociation of the (C-H) bond in the methyl group of toluene. The lower value agrees quite well with Szwarc's, and the higher value turns out to be approxo- mately the average of 77 5 and 89.9. The results of this research-suggest 84 kcal/mole as the upper limit for the activation energy. The ultraviolet spectra of the solid decomposition product indicated that the solid was not pure dibenzyl but probably contained small amounts of a compound possessing a diphenyl nucleus. The rate of formation of hydrogen and methane was found to be inhibited by small amounts of air, and the percentage of hydrogen was found to increase slightly with temperature. A detailed description of the apparatus and its operation is given. The concept of group potential has been introduced to predict bond dissociation energies of carbon-hetero atom and carboncarbon bonds. (auth)
Resistance of <i>Yersinia pestis</i> to Complement-Dependent Killing Is Mediated by the Ail Outer Membrane Protein (2007)

Yersinia pestis, the causative agent of plague, must survive in blood in order to cause disease and to be transmitted from host to host by fleas. Members of the Ail/Lom family of outer membrane proteins provide protection from complement-dependent killing for a number of pathogenic bacteria. The Y. pestis KIM genome is predicted to encode four Ail/Lom family proteins. Y. pestis mutants specifically deficient in expression of each of these proteins were constructed using lambda Red-mediated recombination. The Ail outer membrane protein was essential for Y. pestis to resist complement-mediated killing at 26 and 37 degrees C. Ail was expressed at high levels at both 26 and 37 degrees C, but not at 6 degrees C. Expression of Ail in Escherichia coli provided protection from the bactericidal activity of complement. High-level expression of the three other Y. pestis Ail/Lom family proteins (the y1682, y2034, and y2446 proteins) provided no protection against complement-mediated bacterial killing. A Y. pestis ail deletion mutant was rapidly killed by sera obtained from all mammals tested except mouse serum. The role of Ail in infection of mice, Caenorhabditis elegans, and fleas was investigated.
An exploratory study on collective concept formation in electronic environments (1998)

Effective use of distributed collaboration environments requires shared mental models that guide users in sensemaking and categorization. In Lotus Notes -based collaboration systems, such shared models are usually implemented as views and document types. TeamRoom, developed at Lotus Institute, implements in its design a theory of effective social process that creates a set of team-specific categories, which can then be used as a basis for knowledge sharing, collaboration, and team memory. This paper reports an exploratory study in collective concept formation in the TeamRoom environment. The study was run in an ecological setting, while the team members used the system for their everyday work. We apply theory developed by Lev Vygotsky, and use a modified version of an experiment on concept formation, devised by Lev Sakharov, and discussed in Vygotsky (1986). Vygotsky emphasized the role of language, cognitive artifacts, and historical and social sources in the development of thought processes. Within the Vygotskian framework it becomes clear that development of thinking does not end in adolescence. In teams of adult people, learning and knowledge creation are continuous processes. New concepts are created, shared, and developed into systems. The question, then, becomes how spontaneous concepts are collectively generated in teams, how they become integrated as systems, and how computer mediated collaboration environments affect these processes.
Mouse isolated perfused heart: Characteristics and cautions (2003)

1. Owing to the considerable potential for manipulating the murine genome and, as a consequence, the increasing availability of genetically modified models of cardiovascular diseases, the mouse is fast becoming a cornerstone of animal research. However, progress in the use of various murine preparations is hampered by the lack of facilities and skills for the adequate physiological assessment of genetically modified mice. 2. We have attempted to address this problem by refining and characterizing a mouse isolated heart preparation that was originally developed for use with larger hearts. 3. We used the isolated buffer-perfused Langendorff preparation (perfused at constant flow or constant pressure) to characterize: (i) the frequency-response characteristics; (ii) heart isolation conditions; (iii) perfusion chamber conditions; (iv) temperature-function relationships; (v) stability over extended periods of perfusion; (vi) perfusate calcium-function relationships; (vii) pressure-volume relationships; (viii) pressure-rate relationships; and (ix) flow-function relationships.
Frequency Domain Techniques for Stereo to Multichannel Upmix (2002)

In this paper we propose a series of upmixing techniques for generating multichannel audio from stereo recordings. The techniques use a common analysis framework based on the comparison between the Short-Time Fourier Transforms of the left and right stereo signals. An inter-channel coherence measure is used to identify time-frequency regions consisting mostly of ambience components, which can then be weighed via a non-linear mapping function, and extracted to synthesize ambience signals. A similarity measure is used to identify the panning coefficients of the various sources in the mix in the time-frequency plane, and different mapping functions are applied to unmix (extract) one or more sources, and/or to re-pan the signals into an arbitrary number of channels. We illustrate the application of the various techniques in the design of a two-to-five channel upmix system.
Quantitative analysis of mask misalignment and its effect on device performance (2002)

Mask misalignment associated with contact photolithography fabrication of discrete field-effect transistors (FETs) and monolithic microwave integrated circuits (MMICs) is quantified using three different approaches: FET source and drain resistance measurements, electrical measurement on potentiometer-like test structures, and scanning electron microscope (SEM) examination. The results indicate that, for the current process technology, the FET source and drain resistance measurement is the preferred approach for routine production control of misalignment. The error is typically within 0.1 mu m. Using automated laboratory equipment, a single wafer can be tested in less than 30 min with most of the time spent on equipment setup and data analysis. The actual measurement takes less than 1 s per FET to complete. Often the source and drain resistance data already exist as part of a DC FET screening test routine. The SEM examination, although time consuming, should be done periodically for calibration purposes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>