gebhart/patrepeval huggingface dataset:
A Developmentally Regulated Hydroxyproline-Rich Glycoprotein in Maize Pericarp Cell Walls (1988)

We have studied the accumulation of peptidyl hydroxyproline in the pericarp of developing maize (Zea mays L., Golden cross Bantam sweet corn) kernels. Although this hydroxyproline accumulates throughout development, it is most soluble and its content per milligram dry weight greatest at midmaturation stages of development. Salt-soluble proteins containing this hydroxyproline from isolated cell walls of developing kernels were fractionated on a CsCl density gradient and on a Chromatofocusing column, resulting in the purification of an hydroxyproline-rich glycoprotein, PC-1. PC-1 is a basic protein of approximately 65 to 70 kilodaltons in molecular weight with an isoelectric point of at least 10.2 and a density of 1.38 to 1.39 in CsCl. Amino acid composition data indicate that it is rich in hydroxyproline, threonine, proline, lysine, and glycine. Its relation to dicot extensin is discussed.
Torque studies of large-area Co arrays fabricated by etched nanosphere lithography (2005)

Large-area arrays of size-tunable Co nanomagnets have been fabricated using a methodology based on nanosphere lithography. The technique employs a monolayer of latex spheres as an inverse mask for the formation of Co elements by electrodeposition. By tuning the size of the spheres with reactive ion etching, magnetic elements of 310 and 240nm diameter have been obtained. Analysis of the arrays using high-field torque magnetometry and three-dimensional micromagnetic modeling clearly demonstrates a change in anisotropy as the diameter of the elements is reduced. More detailed investigation of the field dependence indicates the presence of magnetic vortices at low fields.
케니 휠러의 작곡 언어에서의 표준 재즈 작곡 모델의 변화와 확장: 《Gnu High》의 수록곡 , 를 중심으로 (2019)

60년대 등장한 유럽 출신의 재즈 음악가들은 지역성을 바탕으로 한 독특한 음악적 접근, 새로운 음악요소의 도입을 통해 독창적인 사운드를 발견하고자 하였고 이것은 재즈 음악이 보다 다양해지고 현대화하는데 기여하였다. 영국을 기반으로 1960년대 말부터 활동하기 시작한 캐나다 태생의 작곡가, 트럼펫 연주자 케니 휠러는 줄곧 유럽 재즈 현장의 중심에 있었으며 그의 작품들은 재즈 작곡에 대한 현대적 접근법을 예증한다. 이 논문은 휠러의 디스코그라피 중 1976년 ECM 레이블을 통해 발매된 《Gnu High》의 수록곡 , 를 조사하고 휠러의 작곡 요소와 그가 음악을 완성하기 위해 어떻게 이들을 사용하고 조합하였는지를 규명코자 한다. 그의 음악 어법들의 특징들을 확인하기 위해, 녹음된 음악들과 채보된 악보들을 통해 작품들의 선율, 화성, 형식과 구조적 측면을 분석하였다. 이 작품들에서 휠러는 비기능적인 화성 진행들을 사용하고 모드를 혼용함으로써 조성적 경계를 확장하였으며, 음계와 음정들의 시퀀스를 통해 선율을 작성하였다. 그 외 마디 경계를 흐리는 박자의 변화, 확장된 형식과 구조적 변형이 휠러의 작곡 어법의 특징으로 설명된다.
The Propeptide Domain of Membrane Type 1-Matrix Metalloproteinase Acts as an Intramolecular Chaperone when Expressed in transwith the Mature Sequence in COS-1 Cells (2000)

It has been assumed that cleavage of the N-terminal propeptide domain of membrane type-1 matrix metalloproteinase (MT1-MMP) is required for enzyme function. We recently demonstrated that the propeptide domain of MT1-MMP is not cleaved and actually is required for function of the membrane-bound enzyme in transfected COS-1 cells (Cao, J., Drews, M., Lee, H. M., Conner, C., Bahou, W. F., and Zucker, S. (1998) J. Biol. Chem. 273, 34745-34752). In this report, we have inserted the cDNA encoding the signal and propeptide sequences of MT1-MMP (MT(1-109)) and the cDNA encoding propeptide-deleted mature MT1-MMP (MT delta pro) in expression vectors that were then transfected into matrix metalloproteinase-deficient COS-1 cells. Co-expression of both the mature sequence and the prosequence of MT1-MMP as independent polypeptides (in trans) in COS-1 cells resulted in reconstitution of MT1-MMP function in terms of facilitating (125)I-labeled tissue inhibitor of metalloproteinase 2 binding to transfected cells and subsequent activation of progelatinase A. Transfection of cells with either cDNA alone resulted in non-functional cells. These results are consistent with the propeptide sequence of MT1-MMP functioning as an intramolecular chaperone involved in protein folding and trafficking to the cell surface.
Design and Control Characterization of Switched Reluctance Generator for Maximum Output Power (2006)

Maximization of power throughput of switched reluctance generator has been addressed in this paper. Phase self-inductance, phase voltage switching angles, DC bus voltage level and shaft speed of the generator have been identified as design parameters and control variables affecting output power. Depending on the application each one can be defined as either design parameter or control variable. Due to highly nonlinear characteristics of switched reluctance generator, there is no analytical equation for output power in terms of design parameters and control variables. So, iterative simulation of the generator model on the range of design parameters and control variables has been used for finding output power profile. Since it is a multidimensional search space, the number of iterations is very big. Therefore, we have used theoretical knowledge about the generator and practical limitations to narrow the search space and reduce simulation time. Output power profile of a 1hp generator has been presented from simulation results. These results have been verified by experimental measurements on a test-bed in the lab. The results give the performance of switched reluctance generator for the range of machine parameters and control variables. They show the existence of optimal output power and give guidance for design of the generator and its controller.
A Novel Method for the Rapid, Non-Aqueous<i>t</i>-Butoxycarbonylation of Some<sup>17</sup> <i>O</i>-Labeled Amino Acids and<sup>17</sup>O-N.M.R. Parameters of the Products (1986)

17 O-Labeled amino acids are t-butoxycarbonylated without loss of 17 O-labeling by reaction with triethylamine and di-t-butyl dicarbonate in methanol or dimethylformamide and cleavage of the resultant t-butoxycarbonylamino acid ammonium salt by brief treatment with ice-cold dilute hydrochloric acid at pH 2.15.
Functional Mimicry of a Discontinuous Antigenic Site by a Designed Synthetic Peptide (2002)

Functional reproduction of the discontinuous antigenic site D of foot-and-mouth disease virus (FMDV) has been achieved by means of synthetic peptide constructions that integrate each of the three protein loops that define the antigenic site into a single molecule. The site D mimics were designed on the basis of the X-ray structure of FMDV type C-S8c1 with the aid of molecular dynamics, so that the five residues assumed to be involved in antigenic recognition are located on the same face of the molecule, exposed to solvent and defining a set of native-like distances and angles. The designed site D mimics are disulfide-linked heterodimers that consist of a larger unit containing VP2(71-84), followed by a polyproline module and by VP3(52-62), and a smaller unit corresponding to VP1(188-194) (VP=viral protein). Guinea pig antisera to the peptides recognized the viral particle and competed with site D-specific monoclonal antibodies, while inoculation with a simple (not covalently joined to one another) admixture of the three VP1-VP3 sequences yielded no detectable virus-specific serum conversion. Similar results have been reproduced in two bovines. Antisera to the peptides also moderately neutralize FMDV in cell cultures and partially protect guinea pigs against challenge with the virus. These results demonstrate functional mimicry of the discontinuous site D by the peptides, which are therefore obvious candidates for a multicomponent, peptide-based vaccine against FMDV.
Calculation of electric fields induced in the human knee by a coil applicator (2001)

Calculations are presented of the induced electric fields and current densities in the cartilage of the knee produced by a coil applicator developed for applying pulsed magnetic fields to osteoarthritic knees. This applicator produces a sawtooth-like magnetic field waveform composed of a series of 260-micros pulses with a peak to peak magnitude of approximately 0.12 mT in the cartilage region. The simulations were performed using a recently developed 3 dimensional finite difference frequency domain technique for solving Maxwell's equations with an equivalent circuit model. The tissue model was obtained from the anatomically segmented human body model of Gandhi. The temporal peak electric field magnitude was found to be -153 mV/m, averaged within the medial cartilage of the knee for the typical dB/dt excitation levels of this coil. The technique can be extended to analyze other excitation waveforms and applicator designs.
Closed-loop adaptive voltage scaling controller for standard-cell ASICs (2002)

The paper describes a closed-loop controller for adaptive voltage scaling (AVS) where the supply voltage to a standard-cell ASIC is dynamically adjusted to the minimum value required for the desired system speed. The controller includes a clock generator that provides a low-jitter clock to the ASIC at all steady-state operating points and through transients. To speed up the voltage transient response to step changes in clock frequency, the controller is based on a multiple-tap resettable delay line. A chip including the AVS controller and a dual 16-bit MAC application has been fabricated in a standard 0.5 μ CMOS process. The area taken by the AVS controller is 0.12mm2. Experimental results demonstrate operation over the application clock frequency range from 80 kHz to 20 MHz, and a 38μs transient response for a step change in speed from standby to maximum throughput operation.
Epidermal hydration levels in patients with rosacea improve after minocycline therapy (2013)

Patients with PPR have increased erythema indices, normal sebum casual levels, a more alkaline centrofacial region and reduced epidermal hydration levels compared with control subjects. Treatment with systemic minocycline reduces erythema and increases hydration, in the absence of any change in skin pH or sebum casual levels.
A new approach to combretastatin D<sub>2</sub> (2005)

A concise and convergent route to combretastatin D2 is described together with some preliminary biological data.
A Reverse Genetics Platform That Spans the Zika Virus Family Tree (2017)

ABSTRACT Zika virus (ZIKV), a mosquito-borne flavivirus discovered in 1947, has only recently caused large outbreaks and emerged as a significant human pathogen. In 2015, ZIKV was detected in Brazil, and the resulting epidemic has spread throughout the Western Hemisphere. Severe complications from ZIKV infection include neurological disorders such as Guillain-Barré syndrome in adults and a variety of fetal abnormalities, including microcephaly, blindness, placental insufficiency, and fetal demise. There is an urgent need for tools and reagents to study the pathogenesis of epidemic ZIKV and for testing vaccines and antivirals. Using a reverse genetics platform, we generated six ZIKV infectious clones and derivative viruses representing diverse temporal and geographic origins. These include three versions of MR766, the prototype 1947 strain (with and without a glycosylation site in the envelope protein), and H/PF/2013, a 2013 human isolate from French Polynesia representative of the virus introduced to Brazil. In the course of synthesizing a clone of a circulating Brazilian strain, phylogenetic studies identified two distinct ZIKV clades in Brazil. We reconstructed viable clones of strains SPH2015 and BeH819015, representing ancestral members of each clade. We assessed recombinant virus replication, binding to monoclonal antibodies, and virulence in mice. This panel of molecular clones and recombinant virus isolates will enable targeted studies of viral determinants of pathogenesis, adaptation, and evolution, as well as the rational attenuation of contemporary outbreak strains to facilitate the design of vaccines and therapeutics. IMPORTANCE Viral emergence is a poorly understood process as evidenced by the sudden emergence of Zika virus in Latin America and the Caribbean. Malleable reagents that both predate and span an expanding epidemic are key to understanding the virologic determinants that regulate pathogenesis and transmission. We have generated representative cDNA molecular clones and recombinant viruses that span the known ZIKV family tree, including early Brazilian isolates. Recombinant viruses replicated efficiently in cell culture and were pathogenic in immunodeficient mice, providing a genetic platform for rational vaccine and therapeutic design.
650. Dimethylamino-derivatives of monosilane. Preparation, some physical and chemical properties, and pyrolysis (1964)

B. J. Aylett and L. K. Peterson, J. Chem. Soc., 1964, 3429 DOI: 10.1039/JR9640003429
Gastroesophageal Reflux After Distal Gastrectomy: Possible Significance of the Angle of His (1998)

These findings suggest that the angle of His plays a role in reflux after distal gastrectomy and that the severity of reflux may be estimated by measuring this angle.
RAID+: deterministic and balanced data distribution for large disk enclosures (2018)

Existing RAID solutions partition large disk enclosures so that each RAID group uses its own disks exclusively. This achieves good performance isolation across underlying disk groups, at the cost of disk under-utilization and slow RAID reconstruction from disk failures.

We propose RAID+, a new RAID construction mechanism that spreads both normal I/O and reconstruction workloads to a larger disk pool in a balanced manner. Unlike systems conducting randomized placement, RAID+ employs deterministic addressing enabled by the mathematical properties of mutually orthogonal Latin squares, based on which it constructs 3-D data templates mapping a logical data volume to uniformly distributed disk blocks across all disks. While the total read/write volume remains unchanged, with or without disk failures, many more disk drives participate in data service and disk reconstruction. Our evaluation with a 60-drive disk enclosure using both synthetic and real-world workloads shows that RAID+ significantly speeds up data recovery while delivering better normal I/O performance and higher multi-tenant system throughput.
An Electromyographic Analysis of Quadriceps Femoris Muscle Setting and Straight Leg Raising (1983)

Physical therapists routinely advise patients to perform quadriceps femoris muscle setting or straight leg raising or both following knee surgery or trauma from knee injury. Little information exists, however, about the intensity of effort required from knee and hip musculature during the exercises. This study was designed to compare the level of electromyographic activity during maximally resisted straight leg raises with the level during quadriceps femoris muscle setting exercises for the vastus medialis, rectus femoris, gluteus medius, and biceps femoris muscles. Forty healthy young adult men and women performed randomly ordered trials of each exercise in the supine position. Electromyographic activity was recorded from surface electrodes and normalized to values derived from maximal isometric trials. Statistical analysis demonstrated significantly greater (p less than .0001) vastus medialis, biceps femoris, and gluteus medius muscle activity during quadriceps femoris muscle setting. The rectus femoris muscle was significantly more active (p less than .0001) during the straight leg raise. The study demonstrated remarkably different muscle activation levels between the exercises studied and clearly indicates that selection of the exercises needs to be based on the therapeutic objectives.
Fundamental solution and single‐chain properties of polylactides (2005)

Abstract Polylactides (PLA) have been known for several decades and are recently of considerable commercial significance. However, the literature on basic chain properties and solution characterization is divided and inconsistent. In this study, a comprehensive and well‐controlled set of experiments is combined with rigorous quantitative analysis to resolve existing apparent contradictions. Homopolymers and copolymers spanning wide ranges of molecular weight and stereoisomer proportions were prepared by ring‐opening polymerizations of L ‐ and D ‐lactides using stannous octanoate as the catalyst. Samples were characterized by means of: (1) dilute‐solution viscometry in three different solvents; (2) size exclusion chromatography in tetrahydrofuran (THF) with light scattering detection; (3) static multiangle light scattering in a mixed acetonitrile–dichloromethane solvent; (4) variable‐angle spectroscopic ellipsometry; and (5) melt rheology. The data imply that PLA are typical linear flexible polymers; unperturbed PLA chain dimensions are describable in terms of a characteristic ratio of 6.5 ± 0.9, regardless of stereoisomer content. The Schulz‐Blaschke and Mark‐Houwink constants for dilute PLA solutions in chloroform and in THF are determined. For chloroform at 30°C, the correct values are k SB = 0.302, K = 0.0131 (mL/g), and a = 0.759, while for THF at 30°C, the correct values are k SB = 0.289, K = 0.0174 (mL/g), and a = 0.736. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 3100–3111, 2005
Fimbriae (pili): molecular basis of Pseudomonas aeruginosa adherence. (1986)

Pseudomonas aeruginosa produces polar pili which promote the adherence of the organism to host mucosal surfaces and to blood-borne phagocytic cells such as polymorphonuclear leukocytes. Pseudomonas polar pili are flexible filaments of 52 A diameter and 2500 nm average length. They consist of a single type of protein subunit, pilin, of molecular weight 15,000, which is arranged in a helical mode of 5 subunits per turn and a pitch of 41 A. Purified whole pili, and anti-pilus antiserum both inhibited the interaction of Pseudomonas aeruginosa strains with human buccal epithelial cells and PMNs, suggesting that Pseudomonas adherence to these mammalian cells is pilus mediated. No correlation was found between the level of cell surface fibronectin on human buccal endothelial cells and the adherence of Pseudomonas bacteria. Pseudomonas adherence to buccal endothelial cells obtained from patients with cystic fibrosis was somewhat less than that to buccal endothelial cells obtained from healthy individuals. Fibronectin levels on buccal endothelial cells from patients with cystic fibrosis were not significantly different than those found on buccal endothelial cells from healthy individuals. Studies with peptide fragments derived from purified pili showed that only one peptide encompassing 23 amino acid residues at the C-terminus of the pilus protein was able to inhibit in vitro adherence of P. aeruginosa PAK to human buccal cells. This peptide domain was tentatively assigned the receptor-binding function.
Snapshots in Real-Time Databases Using Database Pointer Transactions (2006)

We present 2V-DBP-SNAP, an algorithm that allows hard real-time tasks in an embedded real-time control system to read a snapshot of a number of data elements in a real-time database. Furthermore, 2V-DBP-SNAP allows these data elements to be shared with soft real-time tasks, which access them using a database query language, and with other hard real-time tasks that use database pointers. 2V-DBP-SNAP allows temporal behavior and memory consumption to be accurately predicted. Introducing snapshot transactions is beneficial for embedded control-systems, such as for engine control in an automotive system, since a snapshot of the state of the environment can be collected, e.g., the state of all cylinders in the engine. 2V-DBP-SNAP is lightweight and predictable, both with respect to computational and memory overhead, and is therefore highly suited for resource constrained systems.
A framework for analyzing virtual enterprise infrastructure (1999)

We propose that virtual enterprises can be enabled by extending the existing, and evolving, electronic commerce (EC) infrastructure. This incremental approach to virtual enterprises, based on fairly mature technology and standard services, has the obvious advantage over entirely ad hoc solutions of reducing risks and investment costs. To support this view, we present a general multidimensional view of EC that is not restricted to conducting secure transactions over the Internet-instead, it encompasses the partner types, supply chain lengths, organizational boundaries crossed, and value as well as volume of EC transactions. We then propose a platform for virtual enterprises, highlight its key enabling technologies, and analyze how existing commercial integrated platforms for EC can be extended to support virtual business.
First MMW characterization of ErAs/InAlGaAs/InP semimetal-semiconductor-Schottky diode (S<sup>3</sup>) detectors for passive millimeter-wave and infrared imaging (2005)

We present the first mm-wave characterization of Semimetal Semiconductor Schottky (S3) diodes for direct detector applications from 94 GHz to 30 THz. The S3 devices use molecular-beam epitaxy growth of binary compounds that are closely lattice-matched and crystallographically perfect across the heterointerface to reduce 1/f and burst noise while maintaining ultra-high-frequency performance. The S3 diodes are fabricated from an InAlGaAs/InP based material system with both the Schottky layer and contact layer having n and n+ doping levels. The semimetal Schottky contact is ErAs which is grown in-situ during the MBE growth. By varying the InAlAs percentage content in the epitaxial layer structure, the diode dc I-V characteristics and its zero bias responsivity are optimized. Diode s-parameter data from dc-100 GHz is used to determine the diode responsivity as a function of frequency and diode capacitance and resistance. These measurements then allow the device intrinsic and extrinsic equivalent-circuit elements to be optimized for direct detection from 94 GHz to ~30 THz.
Quantum Illumination with Gaussian States (2008)

An optical transmitter irradiates a target region containing a bright thermal-noise bath in which a low-reflectivity object might be embedded. The light received from this region is used to decide whether the object is present or absent. The performance achieved using a coherent-state transmitter is compared with that of a quantum-illumination transmitter, i.e., one that employs the signal beam obtained from spontaneous parametric down-conversion. By making the optimum joint measurement on the light received from the target region together with the retained spontaneous parametric down-conversion idler beam, the quantum-illumination system realizes a 6 dB advantage in the error-probability exponent over the optimum reception coherent-state system. This advantage accrues despite there being no entanglement between the light collected from the target region and the retained idler beam.
MEMS 및 센서 시스템 / 백색광 간섭기에서 간섭 무늬의 상호 상관관계 함수를 이용한 절대 위상 측정 알고리즘 (2000)

A new signal processing algorithm for white light interferometry has been proposed and investigated theoretically. The goal of the algorithm is to determine the absolute optical path length of an interferometer with very high precision (≪one optical wavelength). The algorithm features cross-correlation of interferometer fringe scans and hypothesis testing. The hypothesis test looks for a zero order fringe peak candidate about which the cross-correlation is symmetric minimizing the uncertainty of misidentification. The shot noise limited performance of the proposed signal processing algorithm has been analyzed using computer simulations. Simulation results were extrapolated to predict the misidentification rate at Signal-to-Shot noise ratio (SNR) higher than 31 dB. Root-mean-square phase error between the computer-generated zero order fringe peak and the estimated zero order fringe peak has been calculated for the changes of three different parameters (SNR, fringe scan sampling rate, coherence length of light source). Results of computer simulations showed the ability of the proposed signal processing algorithm to identify the zero order fringe peak correctly. The proposed signal processing algorithm uses a software approach, which is potentially inexpensive, simple and fast.