gebhart/patrepeval huggingface dataset:
Sample preference for colorectal cancer screening tests: Blood or stool? (2012)

Objective: Despite the high prevalence of CRC and the proven benefits of faecal sampling tests, participation rates in CRC screening are suboptimal. Literature has identified a number of barriers to participation, including faecal aversion. Emerging test technologies suggest blood-based molecular markers might provide an alternative, more acceptable option, for CRC screening tests. We aim to determine preference for blood compared to faeces as the sample for the screening test. Methods: A survey was mailed to 956 South Australians aged 50 to 74 years. Data were collected on sample preference, demographic variables, and ratings of screening test convenience and comfort. Results: The survey yielded a 43% response rate. The majority of participants preferred to provide a blood sample (78% v 22%, p < 0.001). Women were more likely to prefer blood than men (82% vs 74%, p = 0.05). Sample experience influenced preferences, with a significantly higher preference for faeces among participants with experience in faecal sampling (27% vs 17% with no experience, p < 0.05). Participants who preferred to provide a faecal sample rated it significantly more convenient (p < 0.001), more comfortable (p < 0.001), and more acceptable (p < 0.001) than those who preferred blood sampling. Conclusions: Survey participants overwhelmingly indicate a preference for the idea of a blood sample over a faecal sample for CRC screening. Preference was influenced by gender, experience with sampling method and the individual’s perception of sampling convenience, sampling comfort and sample acceptability. Our results suggest population participation rates are likely to improve with blood-based screening tests.
GENETIC POLYMORPHISMS AND SEPSIS (2005)

Sepsis is a polygenic and complex syndrome that is initiated by infection and is characterized by a systemic inflammatory response. Genetic polymorphisms in the immune response to infection have been shown to be associated with clinical outcomes. Functional and association studies involving genetic polymorphisms in essential genes, including Toll-like receptors, cytokines, and coagulation factors, have provided important insights into the mechanisms involved in the pathogenesis of sepsis-induced organ dysfunction. The advancement of high-throughput single nucleotide polymorphism (SNP) genotyping will provide valuable information on the interaction of multiple allelic variants and clinical outcome. More precise categorization of patients based on genetic background is likely to lead to individualized targeted treatment. Future therapeutic trials as well as actual treatment regimens for patients with sepsis are likely to be designed to target specific genotypes and associated cellular responses, maximizing clinical response and patient safety.
Reactions with 4,5‐Disubstituted 2‐Mercaptoimidazoles and their derivatives (1972)

Abstract 4,5‐Disubstituted 2‐mercaptoimidazoles react with chloroacetic acid to form S‐carboxy‐methyl derivatives, which readily cyclise to the corresponding 2,3‐dihydro‐imidazo[2,1‐b]‐thiazol‐3‐ones. Substituted amides of 2‐imidazolylthioacetic acids have now been obtained by the action of amines on the latter compounds. The 2‐arylidene and 2‐arylazo derivatives of 2,3‐dihydroimidazo[2,1‐b]thiazol‐3‐ones are prepared. The action of GRIGNARD reagents on the 2‐arylidene derivatives results in addition to the exocylic double bond.
Implementation of a MAC-layer protocol (GIT-CSMA/CD) for industrial LAN's and its experimental performance (1997)

This paper describes the pilot implementation of a local area network by using a hybrid medium access control (MAC) layer protocol, called group implicit token-carrier sense multiple access with collision detection (GIT-CSMA/CD) developed for hard real-time industrial local area networks (LANs). This protocol outperforms standard CSMA/CD and token-passing protocols, as well as other hybrid protocols, in terms of mean and maximum packet delays versus throughput. Also, GIT-CSMA/CD offers bounded packet delay and a great degree of adaptation to the varying requirements imposed by the user applications. A seven-node pilot network was set up and its experimental performance evaluated. The implementation of the network node is based on the existing microcontroller technology (INTEL 80C3152 Communication Controller) and field programmable gate array (FPGA) logic (XILINX XC3190). The measurements carried out in real time on a 1-Mb/s LAN yielded reproducible results. The comparison between the experimental and the simulation results showed excellent agreement.
The analysis of visual motion: a comparison of neuronal and psychophysical performance (1992)

We compared the ability of psychophysical observers and single cortical neurons to discriminate weak motion signals in a stochastic visual display. All data were obtained from rhesus monkeys trained to perform a direction discrimination task near psychophysical threshold. The conditions for such a comparison were ideal in that both psychophysical and physiological data were obtained in the same animals, on the same sets of trials, and using the same visual display. In addition, the psychophysical task was tailored in each experiment to the physiological properties of the neuron under study; the visual display was matched to each neuron's preference for size, speed, and direction of motion. Under these conditions, the sensitivity of most MT neurons was very similar to the psychophysical sensitivity of the animal observers. In fact, the responses of single neurons typically provided a satisfactory account of both absolute psychophysical threshold and the shape of the psychometric function relating performance to the strength of the motion signal. Thus, psychophysical decisions in our task are likely to be based upon a relatively small number of neural signals. These signals could be carried by a small number of neurons if the responses of the pooled neurons are statistically independent. Alternatively, the signals may be carried by a much larger pool of neurons if their responses are partially intercorrelated.
The Impact of Random Telegraph Signals on the Scaling of Multilevel Flash Memories (2006)

This paper describes for the first time the observation of the threshold voltage (Vth) fluctuation due to random telegraph signal (RTS) in flash memory. We acquired large-scale data of Vth fluctuation and confirm the existence of the tail bits generated by RTS. The amount of Vth broadening due to the tail bits becomes larger as the scaling advances, and reaches to more than 0.3 V in 45-nm node. Thus the RTS becomes prominent issue for the design of multilevel flash memory in 45-nm node and beyond
Learning a Cost Function for Interactive Microscope Image Segmentation (2014)

Quantitative analysis of microscopy images is increasingly important in clinical researchers' efforts to unravel the cellular and molecular determinants of disease, and for pathological analysis of tissue samples. Yet, manual segmentation and measurement of cells or other features in images remains the norm in many fields. We report on a new system that aims for robust and accurate semi-automated analysis of microscope images. A user interactively outlines one or more examples of a target object in a training image. We then learn a cost function for detecting more objects of the same type, either in the same or different images. The cost function is incorporated into an active contour model, which can efficiently determine optimal boundaries by dynamic programming. We validate our approach and compare it to some standard alternatives on three different types of microscopic images: light microscopy of blood cells, light microscopy of muscle tissue sections, and electron microscopy cross-sections of axons and their myelin sheaths.
High mobility and high on/off ratio field-effect transistors based on chemical vapor deposited single-crystal MoS2 grains (2013)

We report the electrical characteristics of field-effect transistors (FETs) with single-crystal molybdenum disulfide (MoS2) channels synthesized by chemical vapor deposition (CVD). For a bilayer MoS2 FET, the field-effect mobility is ∼17 cm2 V−1 s−1 and the on/off current ratio is ∼108, which are much higher than those of FETs based on CVD polycrystalline MoS2 films. By avoiding the detrimental effects of the grain boundaries and the contamination introduced by the transfer process, the quality of the CVD MoS2 atomic layers deposited directly on SiO2 is comparable to or better than the exfoliated MoS2 flakes. The result shows that CVD is a viable method to synthesize high quality MoS2 atomic layers.
Effectiveness of Donepezil in Reducing Clinical Worsening in Patients with Mild-to-Moderate Alzheimer’s Disease (2009)

In this population, donepezil treatment was associated with reduced odds of clinical worsening of AD symptoms. Moreover, patients worsening on donepezil were likely to experience less cognitive decline than expected if left untreated. This suggests that AD patients showing clinical worsening on donepezil may still derive benefits compared with placebo/untreated patients.
HGG-05. CAN MULTIMODAL IMMUNOTHERAPY REPLACE RADIOCHEMOTHERAPY IN COMPLETELY RESECTED ADULT GBM? (2017)

Adults with GBM always relapse, even after complete resection. Therefore radiotherapy with broad margins around the resection cavity is mandatory part of the initial standard of care for these patients, aimed to maximize the local tumor control. Chemotherapy is aimed as function as radiosensitizer and to prolong disease-free survival. Nevertheless, most patients show local and/or even distant tumor re-occurrence more or less shortly after multimodal primary treatment. Hypotheses for this are the infiltrative character of the tumor cells, the residing non-dividing glioma cancer stem cells, chemoresistance, etc. IOZK was confronted with a patient (EORTC RPA class IV) who refused radiochemotherapy and maintenance chemotherapy after complete resection of a left occipital glioblastoma. Pathology showed tissue necrosis, angiogenesis, mitosis and atypical tumor cell nuclei. Molecular classification revealed glioblastoma, IDH wildtye, subtye RTK I. After immunodiagnostic blood sampling, the patient was treated with multimodal immunotherapy consisting of 2 cycles of 6 days Newcastle Disease Virus (NDV) infusions and local modulated electrohyperthermia (mEHT) sessions plus an autologous DC vaccine loaded with serum-derived NDV/mEHT-induced antigenic microparticles + NDV, and additionally four more treatments with NDV infusions + mEHT. Treatment was conducted without any side effect. We observed the induction of tumor antigen-specific IFN-producing T cells measured upon ex vivo stimulation with autologous DCs loaded with a GBM cell line in ELISPOT. At time of writing, 15 months after resection, the patient remains in complete remission with optimal Karnofsky performance index and good quality of life. The % PFS at 12 months in the Stupp 2005 paper is for the total group of patients with radiotherapy alone 9.1% (95%CI 5.8–12.4m). The patient history points to a potential change in paradigm that microscopic infiltrating GBM tumor cells might be brought under permanent control through the combined action of NDV, mEHT and the induction of memory T cells.
Electron paramagnetic resonance studies of low-spin d5 complexes. Trisbidentate complexes of iron(III), ruthenium(III), and osmium(III) with sulfur-donor ligands (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron paramagnetic resonance studies of low-spin d5 complexes. Trisbidentate complexes of iron(III), ruthenium(III), and osmium(III) with sulfur-donor ligandsRichard E. DeSimoneCite this: J. Am. Chem. Soc. 1973, 95, 19, 6238–6244Publication Date (Print):September 1, 1973Publication History Published online1 May 2002Published inissue 1 September 1973https://pubs.acs.org/doi/10.1021/ja00800a015https://doi.org/10.1021/ja00800a015research-articleACS PublicationsRequest reuse permissionsArticle Views637Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
One-Pot Synthesis of Symmetrical and Unsymmetrical Diarylmethanes via Diborylmethane (2012)

A one-pot synthesis of diarylmethanes from air-stable diborylmethane via the Suzuki-Miyaura cross-coupling reaction is described. The present approach realizes the synthesis of various symmetrical and unsymmetrical diarylmethanes in good to excellent yields.
Type I IFN Receptor Signals Directly Stimulate Local B Cells Early following Influenza Virus Infection (2006)

Rapidly developing Ab responses to influenza virus provide immune protection even during a primary infection. How these early B cell responses are regulated is incompletely understood. In this study, we show that the first direct stimulatory signal for local respiratory tract B cells during influenza virus infection is provided through the type I IFNR. IFNR-mediated signals were responsible for the influenza infection-induced local but not systemic up-regulation of CD69 and CD86 on virtually all lymph node B cells and for induction of a family of IFN-regulated genes within 48 h of infection. These direct IFNR-mediated signals were shown to affect both the magnitude and quality of the local virus-specific Ab response. Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses.
Peptide mimotopes of carbohydrate antigens (1998)

Carbohydrate structures have been identified as significant antigens for bacterial, viral, and fungal pathogens as well as targets on human tumor cells. Many of these antigens are poorly immunogenic in humans, requiring extensive adjuvant sublimation. Although conjugate carbohydrate vaccines appear promising, there are limitations of using carbohydrate formulations. An alternative approach is to use surrogate antigens for some carbohydrates. We are developing peptides that mimic carbohydrates which might be further manipulated to induce responses that target biologically important carbohydrates expressed on pathogens and on tumor cells. We have shown that peptide mimotopes of carbohydrates induce immune responses to carbohydrate structures with in vivo and vitro functionality. Model systems include the Neisseria group C meningococcal polysaccharide; the histo-blood group-related antigens expressed on tumor cells; and mannose, sialyl, and histo-blood group-related carbohydrate epitopes expressed on human immunodeficiency virus.
Upper Airway Epithelial Structural Changes in Obstructive Sleep-disordered Breathing (2002)

The etiology of upper airway collapsibility in patients with snoring and obstructive sleep apnea (OSA) remains unclear. Structural mucosal changes could be contributory factors. The objective of this study was to determine whether pathologic changes in the epithelium or the epithelial-connective tissue interface are present in patients with snoring and/or OSA by means of scanning electron microscopy and immunohistochemistry. Uvulae were obtained by uvulopalatopharyngoplasty from three patients with habitual snoring and nine patients with mild to severe OSA, as well as by dissection from 43 nonsnoring body donors. Scanning electron microscopy revealed structural changes in the epithelial-connective tissue boundary that significantly differed from age-related changes in the control subjects. The immunohistochemical staining with antibodies against epithelial cytokeratins showed differences in the expression pattern of cytokeratin 13 between patients and control subjects. No differences were found in the distribution pattern of laminin. Analysis of defense cells revealed a significant diffuse infiltration of leukocytes, mainly T cells, inside the lamina propria of the patient group, which was not observed in the control group. In conclusion, these results support the hypothesis that progressive structural changes in the mucosa caused by the trauma of snoring are a possible contributory factor to upper airway collapsibility.
Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization. (1981)

Trichilemmal keratinization, first described in Maurer in 1895 and rediscovered by Holmes (1968) and Pinkus (1968) converts the stratified epithelium of the outer root sheath into anuclear keratin without an intervening keratohyalin layer. It is a distinct seventh type of keratinization in the hair follicle, not derived from the hair matrix. It occurs wherever outer root sheath is not apposed to inner root sheath, in anagen in the zone of sloughing just below the opening of the sebaceous duct, in catagen in the trichilemmal sac surrounding the lower end of the dying hair shaft where it forms the club of the telogen hair. Electron microscopic study of the thick hairs of dogs (but not the tiny hairs of rodents) reveals intricate infoldings of non-keratinized and keratinized cells. It also shows unique ladder-like membrane coating granules in anagen, which are strongly acid phosphatase-positive and are suggested to be the source of enzyme involved with disintegration of the inner root sheath.
Labeling library functions in stripped binaries (2011)

Binary code presents unique analysis challenges, particularly when debugging information has been stripped from the executable. Among the valuable information lost in stripping are the identities of standard library functions linked into the executable; knowing the identities of such functions can help to optimize automated analysis and is instrumental in understanding program behavior. Library fingerprinting attempts to restore the names of library functions in stripped binaries, using signatures extracted from reference libraries. Existing methods are brittle in the face of variations in the toolchain that produced the reference libraries and do not generalize well to new library versions. We introduce semantic descriptors, high-level representations of library functions that avoid the brittleness of existing approaches. We have extended a tool, unstrip, to apply this technique to fingerprint wrapper functions in the GNU C library. unstrip discovers functions in a stripped binary and outputs a new binary, with meaningful names added to the symbol table. Other tools can leverage these symbols to perform further analysis. We demonstrate that our semantic descriptors generalize well and substantially outperform existing library fingerprinting techniques.
<title>Comparison of primary and complementary color filters for CCD-based digital photography</title> (1999)

This paper presents a comparison between primary (RGB) and complementary (CYMG) CCD color filters arrays, as applied to digital photography. Our analysis is based upon the measured spectral characteristics of the primary and complementary color versions of the Matsushita MN3776 CCD. The important role of the color correction matrix on the quality of the image is considered both in terms of noise and color saturation. Our calculations show that there is a tradeoff between color saturation and ISO speed, when complementary filters are used. Complementary color filters only gain an ISO speed advantage when the color saturation is low. When the color correction matrix is chosen to make the ISO speeds of the two filter systems equivalent, the well capacity of the complementary CCD must be significantly higher because of the higher overall transmission of its color filters. Our comparison includes ISO speed calculations and plots of the color gamut for primary and complementary color filters with various color correction matrices. We conclude that primary color filters are superior for digital photography.
SENCAR Mouse Skin Tumorigenesis Model versus Other Strains and Stocks of Mice (1986)

The SENCAR mouse stock was selectively bred for eight generations for sensitivity to skin tumor induction by the two-stage tumorigenesis protocol using 7,12-dimethylbenz(a)anthracene (DMBA) as the initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as the promoter. The SENCAR mouse was derived by crossing Charles River CD-1 mice with skin-tumor-sensitive mice (STS). The SENCAR mice are much more sensitive to both DMBA tumor initiation and TPA tumor promotion than CD-1, BALB/c, and DBA/2 mice. An even greater difference in the sensitivity to two-stage skin tumorigenesis is apparent between SENCAR and C57BL/6 mice when using DMBA-TPA treatment. However, the SENCAR and C57BL/6 mice have a similar tumor response to DMBA-benzoyl peroxide treatment, suggesting that TPA is not an effective promoter in C57BL/6 mice. The DBA/2 mice respond in a similar manner to the SENCAR mice when using N-methyl-N-nitro-N-nitrosoguanidine (MNNG)-TPA treatment. The SENCAR mouse model provides a good dose-response relationship for many carcinogens used as tumor initiators and for many compounds used as tumor promoter. When compared to other stocks and strains of mice, the SENCAR mouse has one of the largest data bases for carcinogens and promoters.
Affinity‐Specific protein separations using ligand‐coupled particles in aqueous two‐phase systems: I. Process concept and enzyme binding studies for pyruvate kinase and alcohol dehydrogenase from <i>Saccharomyces cerevisiae</i> (1989)

A process using ligand-coupled particles in aqueous polyethylene glycol-dextran two-phase polymer systems was developed to achieve a highly selective, scaleable biochemical separation process. Product protein is bound to the ligand-coupled particles that quantitatively distribute to the polyethylene glycol-rich upper phase. Other proteins and contaminants partition preferentially to the dextran-rich lower phase.The process offers significant advantages over affinity partitioning here the ligand is coupled to the backbone of a polyethylene glycol polymer. These advantages include a much wider diversity of ligands that can be coupled to particles and more effective confinement of the ligand in the process. Affinity partition with ligands coupled to particles is more amenable to scale-up than is affinity chromatography. A variety of commercially available Sepharose-based particles are suitable for this process. Homogenates from Saccharomyces cerevisiae, which is genetically altered to overproduce pyruvate kinase, and Cibacron blue F3G-A-coupled Sepharose particles are used as a model system for the process. Binding studies with/without aqueous two-phase systems show that the formation of a two-phase system after the adsorption equilibrium is reached does not affect the apparent dissociation constant. Binding of protein to ligand-coupled particles is more rapid in single-phase systems than in the polymer two-phase system. Single-phase binding eliminates the mass transfer resistance associated with redistribution of product protein from the dextran-rich bottom phase to the polyethylene glycol-rich top phase.