gebhart/patrepeval huggingface dataset:
Realtime assessment of foot orientation by Accelerometers and Gyroscopes (2015)

Abstract Foot orientation can be assessed in realtime by means of a foot-mounted inertial sensor. We consider a method that uses only accelerometer and gyroscope readings to calculate the foot pitch and roll angle, i.e. the foot orientation angle in the sagittal and frontal plane, respectively. Since magnetometers are avoided completely, the method can be used indoors as well as in the proximity of ferromagnetic material and magnetic disturbances. Furthermore, we allow for almost arbitrary mounting orientation in the sense that we only assume one of the local IMU coordinate axes to lie in the sagittal plane of the foot. The method is validated with respect to a conventional optical motion capture system in trials with transfemoral amputees walking with shoes and healthy subjects walking barefoot, both at different velocities. Root mean square deviations of less than 4° are found in all scenarios, while values near 2° are found in slow shoe walking. This demonstrates that the proposed method is suitable for realtime application such as the control of FES-based gait neuroprostheses and active orthoses.
A new start (2008)

A middle-management promotion to a new school? Deputy head Jo Smith offers some top tips
Role of cMET in the Development and Progression of Colorectal Cancer (2013)

Mesenchymal-epithelial transition (MET) is a member of a distinct subfamily of heterodimeric receptor tyrosine kinase receptors that specifically binds the hepatocyte growth factor (HGF). Binding to HGF leads to receptor dimerization/multimerization and phosphorylation, resulting in its catalytic activation. MET activation drives the malignant progression of several tumor types, including colorectal cancer (CRC), by promoting signaling cascades that mainly result in alterations of cell motility, survival, and proliferation. MET is aberrantly activated in many human cancers through various mechanisms, including point mutations, gene amplification, transcriptional up-regulation, or ligand autocrine loops. MET promotes cell scattering, invasion, and protection from apoptosis, thereby acting as an adjuvant pro-metastatic gene for many tumor types. In CRC, MET expression confers more aggressiveness and worse clinical prognosis. With all of this rationale, inhibitors that target the HGF/MET axis with different types of response have been developed. HGF and MET are new promising targets to understand the pathogenesis of CRC and for the development of new, targeted therapies.
Case Study Shows Benefits of Applying Hollow Glass Spheres to Drilling Fluids (2015)

This article, written by Special Publications Editor Adam Wilson, contains highlights of paper SPE 174010, “Hollow-Glass-Sphere Application in Drilling Fluids: Case Study,” by Arminder Minhas, SPE, Halliburton; Brandon Friess, SPE, Farid Shirkavand, and Barry Hucik, Seven Generations Energy; Teresa Pena-Bastidas, 3M Canada; Bradley Ross, SPE, Halliburton; and Shawn Servinski and Frank Angyal, Seven Generations Energy, prepared for the 2015 SPE Western Regional Meeting, Garden Grove, California, USA, 27–30 April. The paper has not been peer reviewed. In an effort to optimize drilling operations and economics, an operator examined the effect of adding hollow glass spheres (HGSs) directly to the drilling fluid instead of performing underbalanced drilling. Both nitrogen and HGSs were believed to reduce hydrostatic pressure of the mud column in the hole, resulting in higher drilling rates of penetration (ROPs) and reduced mud losses to the wellbore. This paper provides information on HGSs as an economic alternative to nitrogen to help reduce the hydrostatic pressure of invert-emulsion drilling fluids. Introduction This case study focuses on the application of HGSs in two different sections of the drilling operation—a horizontal section and a vertical intermediate section. Data from a base-case horizontal section using an all-oil drilling fluid were compared with data of another well on the same drilling pad using the same fluid with the addition of HGSs. The intermediate-section data were from a base-case well that used an invert-emulsion drilling fluid, and they were compared with data from other intermediate well intervals in the same field that used an invert-emulsion drilling fluid with the addition of HGSs. Use of HGSs in Drilling Fluids HGSs are inert materials that are used as density-reducing agents. In the oil and gas industry, they are used for reducing the density of drilling fluids and cement blends. These hollow spheres (Fig. 1) are chemically inert, thermally stable (with a softening temperature of 600°C), and made of soda-lime borosilicate with a high strength/density ratio, and they can be added to both oil- and water-based fluids. A density reduction of up to 2.086 lbm/gal is possible when using HGSs. HGS addition helps reduce density and, consequently, the effective circulating density (ECD). Addition of HGSs to a lightweight drilling fluid allows consistent, stable properties and allows for measurement while drilling and controlled management of fluid properties. These lightweight fluids can be used for drilling at balanced, near-balanced, or underbalanced conditions. Applications include depleted reservoirs, geologically fractured formations, poorly consolidated formations, and high-permeability formations. In general, a reduction of differential pressure can result in the elimination of differential sticking, reduction or elimination of fluid loss, and mitigation of formation damage. This can result in higher productivity during drilling operations and during production.
Statut légal spécial des établissements de crédit dispensés des formalités en cas d'endossement à leur ordre d'une copie d'acte constatant une créance hypothécaire (1999)

International audience
Early Detection of the &lsquo;Endometrial Resection Syndrome&rsquo; (1996)

We report a patient who developed symptoms of fluid overload after having absorbed 3 litres of irrigating fluid during transcervical resection of the endometrium. Four methods were used to measure the absorption at 10-min intervals throughout the operation. There were strong intercorrelations between the results of these monitoring methods, which consisted in breath ethanol analyses and measurements of the serum sodium and glycine concentrations and of the volumetric fluid balance. However, the ethanol method was easiest to perform and provided immediate results. This monitoring gave the operating team as much as 45 min to prevent further absorption before it became large enough to elicit a transcervical endometrial resection syndrome.
Binding Affinities for a Series of Selective Inhibitors of Gelatinase-A Using Molecular Dynamics with a Linear Interaction Energy Approach (2001)

The binding of a series of hydroxamate inhibitors with gelatinase-A is examined to evaluate the viability of calculating free energies of binding, ΔGb, utilizing molecular dynamics (MD) simulations with a linear interaction energy approach. In our simulations, a bonded model was used to represent the potentials of the catalytic zinc center. The electrostatic distribution of this model was derived using a two-stage electrostatic potential fitting calculations. The resulting bonded model was then used to generate the MD trajectories. Coulombic, van der Waals, and coordinate bond energy components determined from MD simulations of the bound and unbound inhibitors solvated in water were correlated with the free energies of binding for the 15 hydroxamate inhibitors. In the correlation process, several linear models consisted of different energy components were tested. We found that besides the usually used Coulombic and van der Waals energy terms, the introduction of a constant term could significantly improve the correlation. The best model yields an average error of 0.6 kcal/mol for the 15 binding affinities, which cover an observed range of 7.2 kcal/mol. The predictive ability of the best model was revealed by the high value of q2 (0.854) from the leave-one-out cross-validation. To this series of inhibitors, the constant term can be treated as effective adjustment to the entropy contribution in the binding free energies. The MD simulations predicted the binding mode of the gelatinase-A with the studied inhibitors, and also provided insights into the interactions occurring in the active site and the origins of variations in ΔGb. The P1‘ groups of inhibitors make extensive van der Waals and hydrophobic contacts with the nonpolar side chains of four residues in the S1‘ subsite, including Leu 197, Val 198, Leu 218, and Tyr 223, which directly influence the ligand binding. Hydrogen bonds between hydroxamates and gelatinase-A are very important to stabilize the inhibitors in the active site. The hydrogen bonds between the P3‘ group and gelatinase-A can produce more favorable electrostatic interactions.
Convergent Transmission of RNAi Guide-Target Mismatch Information across Argonaute Internal Allosteric Network (2012)

In RNA interference, a guide strand derived from a short dsRNA such as a microRNA (miRNA) is loaded into Argonaute, the central protein in the RNA Induced Silencing Complex (RISC) that silences messenger RNAs on a sequence-specific basis. The positions of any mismatched base pairs in an miRNA determine which Argonaute subtype is used. Subsequently, the Argonaute-guide complex binds and silences complementary target mRNAs; certain Argonautes cleave the target. Mismatches between guide strand and the target mRNA decrease cleavage efficiency. Thus, loading and silencing both require that signals about the presence of a mismatched base pair are communicated from the mismatch site to effector sites. These effector sites include the active site, to prevent target cleavage; the binding groove, to modify nucleic acid binding affinity; and surface allosteric sites, to control recruitment of additional proteins to form the RISC. To examine how such signals may be propagated, we analyzed the network of internal allosteric pathways in Argonaute exhibited through correlations of residue-residue interactions. The emerging network can be described as a set of pathways emanating from the core of the protein near the active site, distributed into the bulk of the protein, and converging upon a distributed cluster of surface residues. Nucleotides in the guide strand "seed region" have a stronger relationship with the protein than other nucleotides, concordant with their importance in sequence selectivity. Finally, any of several seed region guide-target mismatches cause certain Argonaute residues to have modified correlations with the rest of the protein. This arises from the aggregation of relatively small interaction correlation changes distributed across a large subset of residues. These residues are in effector sites: the active site, binding groove, and surface, implying that direct functional consequences of guide-target mismatches are mediated through the cumulative effects of a large number of internal allosteric pathways.
Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-ary1-8-alkyl pyrazolo(3,4-b)indoles (2010)

A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles 4a-j, 5a-j and 6a-j has been synthesized and tested for their anti-inflammatory and anticonvulsant activities. Formation of the pyrazoloindole derivatives was achieved by treating arylhydrazones of N-alkyl indole-3-carbox-aldehydes 1a-j, 2a-j and 3a-j with ten times their mass of polyphosphoric acid as a condensing agent. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anticonvulsant activities compared to indomethacin, flufenamic acid and diazepam as positive controls. Detailed synthesis, spectroscopic and toxicity data are reported.
A kind of switch current source with high order LC filter output (2010)

a kind of switch current source with feedback loop compensation is presented in this paper to solve the problem that switching current source can not be applied in high-precision circuit. A good tradeoff has been made by this type of switch current source in improving the dynamic response and reducing low ripple. At the beginning of the paper, the model of BUCK-type circuit is built after analyzing the circuit. Next, the main factor which affects the stability of the system, the filter, is emphasized. The contradiction of high out band rejection and high stability which exists in LC filter is pointed out. To solve this problem, the program of feedback loop compensation is proposed; to verify this program the simulation result is presented. Finally, the implementation circuit of switch current source with high order LC filter output is presented.
Immunotherapy of Recurrent Herpes Labialis With Squaric Acid (2017)

This randomized placebo-controlled study examines the results of squaric acid dibutyl ester for the treatment of herpes labialis in adults.
A Human Monoclonal Antibody to rh<sup>G</sup> (1986)

Hybridomas secreting a human monoclonal IgG1 antibody against a variant of the rhG antigen were produced from B lymphocytes of an Rh-negative donor with serum antibodies to D and G [correction of C] antigens. The antibody reacts by indirect hemagglutination with nearly all C- or D-positive cells, confirming the strong association in the expression of G with D or C antigens. The lack of antibody reactivity to C-negative Du cells suggests a particular epitope on the D complex associated with the G antigen.
A new method for generating axially-symmetric and radially-polarized beams (2005)

A scheme for generating axially-symmetric and radially-polarized beams is proposed by using two diffractive phase elements (DPEs) made of birefringent materials. The design of these two DPEs is based on the general theory of phase-retrieval of optical system in combination with an iterative algorithm. The first DPE is used for demultiplexing two orthogonally linearly-polarized light beams to produce diffractive patterns, and the second DPE is used for compensating the phase difference to obtain the desired radially-polarized beam.
Miscibility of poly(acrylonitrile-co-styrene) with poly[styrene-co-(maleic anhydride)] and poly[styrene-co-(N-phenylmaleimide)] (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMiscibility of poly(acrylonitrile-co-styrene) with poly[styrene-co-(maleic anhydride)] and poly[styrene-co-(N-phenylmaleimide)]Yuji AokiCite this: Macromolecules 1988, 21, 5, 1277–1282Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/ma00183a017https://doi.org/10.1021/ma00183a017research-articleACS PublicationsRequest reuse permissionsArticle Views440Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Occupational Career Revisited (2001)

Abstract The concept of occupational career was first proposed by Black in the 1970s within the occupational behavior frame of reference. This model reflected the career choice literature of the time and relied heavily on role theory, general systems theory, human development, and occupational choice. The concept of occupational career is revisited here in light of the evolving discipline of occupational science, changes in the concept of career, and changes in society. A new model is proposed for examining not only the occupational career of an individual but also the concept that every occupation has a career. The new formulation retains themes of human development, choice, and career, as well as incorporating notions of meaning, context. It replaces the notion of role with that of occupation. The feedback loop of general systems theory from the original model is expanded to a more complex structure as suggested by dynamic systems theory.
근대 루마니아 예술 I (2005)

서유럽 중심의 예술가와 예술 작품을 기준으로 하여 정리되는 예술사에서 결코 소홀히 다룰 수 없는 국가가 루마니
아이다. 루마니아는 19세기 초반까지 세계 예술사에서 그 흔적을 찾아보기 어렵지만 19세기 중반부터 독립된 국가 체
제에 돌입하면서 문화 예술 면에 그 저력을 드러내기 시작한다. 좀 늦은 감이 있지만, 그렇게 시작된 루마니아 예술의
역사는...
<i>In vitro</i>biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1 (2008)

The main objective of the study was to examine the biotransformation of the anticancer drug imatinib in target cells by incubating it with oxidoreductases expressed in tumor cells. The second objective was to obtain an in silico prediction of the potential activity of imatinib metabolites. An in vitro enzyme kinetic study was performed with cDNA expressed human oxidoreductases and LC-MS/MS analysis. The kinetic parameters (Km and Vmax) were determined for six metabolites. A molecular modeling approach was used to dock these metabolites to the target Abl or Bcr-Abl kinases. CYP3A4 isozyme showed the broadest metabolic capacity, whereas CYP1A1, CYP1B1 and FMO3 isozymes biotransformed imatinib with a high intrinsic clearance. The predicted binding modes for the metabolites to Abl were comparable to that of the parent drug, suggesting potential activity. These findings indicate that CYP1A1 and CYP1B1, which are known to be overexpressed in a wide range of tumors, are involved in the biotransformation of imatinib. They could play a role in imatinib disposition in the targeted stem, progenitor and differentiated cancer cells, with a possible contribution of the metabolites toward the activity of the drug.
Pedestrian Dynamics (2009)

Homeland security, transportation, and city planning depend upon well-designed evacuation routes. You can’t wait until the day of to realize your plan won’t work. Designing successful evacuation plans requires an in-depth understanding of models and control designs for the problems of traffic flow, construction and road closures, and the intangible human factors. Pedestrian Dynamics: Mathematical Theory and Evacuation Control clearly delineates the derivation of mathematical models for pedestrian dynamics and how to use them to design feedback controls for evacuations. The book includes: Mathematical models derived from basic principles Mathematical analysis of the model Details of past work MATLAB® code 65 figures and 400 equations Unlike most works on traffic flow, this book examines the development of optimal methods to effectively control and improve pedestrian traffic flow. The work of a leading expert, it examines the differential equations applied to conservation laws encountered in the study of pedestrian dynamics and evacuation control problem. The author presents new pedestrian traffic models for multi-directional flow in two dimensions. He considers a range of control models in various simulations, including relaxed models and those concerned with direction and magnitude velocity commands. He also addresses questions of time, cost, and scalability. The book clearly demonstrates what the future challenges are and provides the tools to meet them.
White-light Fizeau interferometer (1997)

A white-light Fizeau interferometer is described. Commonly, white-light fringes can be produced only by using a virtual wedge instrument such as a Michelson interferometer. By use of a series arrangement of a Fabry-Perot interferometer in front of a two-beam Fizeau interferometer, white-light fringes can be produced. For white-light fringes to be obtained, the thickness of the air gap between the Fizeau plates has to be adjusted to the same thickness as the air gap between the Fabry-Perot plates (or in more general terms to a rational multiple of this value). The contrast of the two-beam type of Fizeau fringes depends on the reflectivity of the Fabry-Perot plates.
Untersuchungen zur subzellulären Lokalisation und zu den Funktionen von YB-1, einem Y-Box-Protein in Säugerzellen (1999)

YB-1, ein Y-Box-Protein in Säugerzellen, konnte sowohl im Zytoplasma als auch in den Zellkernen von HeLa-Zellen nachgewiesen werden. Es wurde eine Abhängigkeit der intrazellulären Lokalisation von YB-1 vom Verlauf des Zellzyklus beobachtet. In jeder Phase des Zellzyklus war YB-1 im Zytoplasma zu finden. Eine Kernlokalisation von YB- 1 konnte nur in den HeLa-Zellen festgestellt werden, die sich im Übergang von der G1- in die S-Phase oder in der frühen S-Phase des Zellzyklus befanden. Die Abhängigkeit der Lokalisation von YB-1 vom Verlauf des Zellzyklus unterstützt die These, daß YB-1 und andere Y-Box-Proteine an der Regulation der Zellproliferation beteiligt sind. Es wurden verschiedene Proteine identifiziert, die im Zytoplasma von HeLa-Zellen mit YB-1 assoziiert vorkommen. Alle identifizierten Proteine erfüllen Aufgaben im RNA-Metabolismus, was auf eine Beteiligung dieser Proteinkomplexe an der Regulation der mRNA hinweist. Die Interaktion von P32/SF2 (P35) mit YB-1 erwies sich als abhängig vom Zellzyklus, wobei eine maximale Assoziation dieser beiden Proteine beim Übergang der HeLa-Zellen von der G1- in die S-Phase zu beobachten war. In Multidrug-resistenten MCF7/ADR-Zellen konnte eine deutlich verstärkte Interaktion von P32/SF2 mit YB-1 im Vergleich zu den sensitiven MCF7-Zellen festgestellt werden. Im Zytoplasma von HeLa-Zellen konnte YB-1 in Verbindung mit membrangebundenen Polysomen nachgewiesen werden. Eine Assoziation von YB-1 mit freien oder zytoskelettgebundenen Polysomen konnte nicht festgestellt werden. Damit wurde erstmalig gezeigt, daß YB-1 eine Spezifität für eine bestimmte Gruppe von Polysomen besitzt. Die Assoziation mit membrangebundenen Polysomen legte die Vermutung nahe, daß YB-1 an der Translationskontrolle von Polypeptiden beteiligt ist, die am rauhen endoplasmatischen Retikulum synthetisiert werden. Es konnte gezeigt werden, daß YB-1 die Translation von P-Glykoprotein, einem integralen Membranprotein, positiv reguliert. Ein Einfluß auf die Translation der untersuchten sekretorischen Proteine (a-Faktor und Präprolactin) konnte nicht beobachtet werden. Diese Ergebnisse belegen, daß YB-1 ein spezifischer Regulator der Translation bestimmter Membranproteine ist. Am Hand von P-Glykoprotein konnte des weiteren demonstriert werden, daß YB-1 sowohl die Transkription als auch die Translation dieses Proteins positiv reguliert. Die in den Zellkulturen beobachtete Korrelation von YB-1 mit der Expression von P-Glykoprotein konnte auch in primären Mammakarzinomen nachgewiesen werden. Somit ist YB-1 ein entscheidender Faktor bei der Ausbildung einer intrinsischen multiplen Resistenz von Mammakarzinomen gegen die Behandlung mit Chemotherapeutika. Aus diesem Grunde könnte YB-1 einen Ansatzpunkt für die künftige Diagnose und Therapie von Mammakarzinomen und eventuell auch von anderen Tumoren bieten.