gebhart/patrepeval huggingface dataset:
CONSTANS and the CCAAT Box Binding Complex Share a Functionally Important Domain and Interact to Regulate Flowering of <i>Arabidopsis</i> (2006)

The CCT (for CONSTANS, CONSTANS-LIKE, TOC1) domain is found in 45 Arabidopsis thaliana proteins involved in processes such as photoperiodic flowering, light signaling, and regulation of circadian rhythms. We show that this domain exhibits similarities to yeast HEME ACTIVATOR PROTEIN2 (HAP2), which is a subunit of the HAP2/HAP3/HAP5 trimeric complex that binds to CCAAT boxes in eukaryotic promoters. Moreover, we demonstrate that CONSTANS (CO), which promotes Arabidopsis flowering, interacts with At HAP3 and At HAP5 in yeast, in vitro, and in planta. Mutations in CO that delay flowering affect residues highly conserved between CCT and the DNA binding domain of HAP2. Taken together, these data suggest that CO might replace At HAP2 in the HAP complex to form a trimeric CO/At HAP3/At HAP5 complex. Flowering was delayed by overexpression of At HAP2 or At HAP3 throughout the plant or in phloem companion cells, where CO is expressed. This phenotype was correlated with reduced abundance of FLOWERING LOCUS T (FT) mRNA and no change in CO mRNA levels. At HAP2 or At HAP3 overexpression may therefore impair formation of a CO/At HAP3/At HAP5 complex leading to reduced expression of FT. During plant evolution, the number of genes encoding HAP proteins was greatly amplified, and these proteins may have acquired novel functions, such as mediating the effect of CCT domain proteins on gene expression.
Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans (2011)

Reduction of body temperature has been proposed to contribute to the increased lifespan in calorie restricted animals and mice overexpressing the uncoupling protein-2 in hypocretin neurons. However, nothing is known regarding the long-term effects of calorie restriction (CR) with adequate nutrition on body temperature in humans. In this study, 24-hour core body temperature was measured every minute by using ingested telemetric capsules in 24 men and women (mean age 53.7 ± 9.4 yrs) consuming a CR diet for an average of 6 years, 24 age- and sex-matched sedentary (WD) and 24 body fat-matched exercise-trained (EX) volunteers, who were eating Western diets. The CR and EX groups were significantly leaner than the WD group. Energy intake was lower in the CR group (1769 ± 348 kcal/d) than in the WD (2302 ± 668 kcal/d) and EX (2798 ± 760 kcal/d) groups (P < 0.0001). Mean 24-hour, day-time and night-time core body temperatures were all significantly lower in the CR group than in the WD and EX groups (P ≤ 0.01). Long-term CR with adequate nutrition in lean and weight-stable healthy humans is associated with a sustained reduction in core body temperature, similar to that found in CR rodents and monkeys. This adaptation is likely due to CR itself, rather than to leanness, and may be involved in slowing the rate of aging.
Demonstration and Commercialization of Zero-Emission Power Plants (2004)

Clean Energy Systems (CES), of Sacramento CA, has developed and demonstrated a technology that allows construction and operation of efficient, zero-emission power plants. The enabling oxy-fueled gas generator and reheater technologies have been successfully demonstrated under programs, cofunded by the California Energy Commission (CEC) and the Department of Energy (DOE) National Energy Technology Laboratory (NETL). In 2002, the CEC awarded CES $2 million to build and operate a 500 kWe natural gas fired zero-emission demonstration power plant based on CES technology. That program was restructured in 2003 to change the demonstration site to CES’ recently acquired “Kimberlina” power plant and to increase the scale of the demonstrations from 500 kWe to 5 MWe. This new site and facility provide broadly expanded test and demonstration opportunities and will shorten the time to commercialization of CES technology. Plant-level 5 MWe demonstrations of the CES technology will be conducted in 2004. The facility will be developed in stages in 2005 to accommodate additional types of demonstrations that can include operation on gasified biomass or coal and the use of gas turbines in the power cycle. These demonstrations set the stage for firstgeneration zero-emissions power plant (ZEPP) projects as early as 2005. Three such projects in the 40-70 MWe range are described. CES’ ZEPP technology, combined with modern gasification technology, will make possible zero-emission coal fired power plants of modest size (≥ 50 MWe) within 5 years and very efficient large-scale (400-1000 MWe) plants within 10 years.
The Bonds of Development: An Attachment-Caregiving Model of Supervision (2010)

In this paper we introduce the Attachment-Caregiving Model of Supervision (ACMS) and its normative functioning. This framework emphasizes the caregiving and attachment processes in the supervisor-trainee relationship and their link to learning. We provide a brief overview of attachment theory, describe the ACMS process, illustrate concepts with a case scenario, note relevant individual differences, and conclude by clarifying the model's contributions and limitations.
Study of PET Depolymerization Catalyzed by Metal Oxide with Different Acidity/Basicity under Microwave Irradiation (2011)

In this paper, the PET depolymerization catalyzed by metal oxides (MgO, CdO, Cu 2 O, Sb 2 O 3 , MnO 2 , V 2 O 5 , SiO 2 , MoO 3 ) under microwave irradiation were investigated, and the effects of acid-base on PET depolymerization was studied by acid-base scale method. The results indicated that the stronger the acidity or basicity of metal oxide was, the better the effects of catalytic depolymerization of PET appeared. Compared with alkali metal oxide, the catalytic effect of acid metal oxide to PET depolymerization was better.
Improving IT quality (1995)

While IT has been widely used to facilitate right‐sizing, the role of IT in the quality movement has been proven but underutilized. Companies focusing on quality to increase revenues have seen dramatic results, improving products and services severalfold, with half the number of employees. IT has helped those organizations design goods that are easier to manufacture, improve new product cycle time through cross‐functional integration of systems, and use electronic networks to speed up communications internally and with suppliers and customers. Yet most IT departments have been reactive rather than proactive, involved only peripherally in their organization′s total quality programmes. Quality improvement is vital to companies trying to thrive in an increasingly competitive environment, and IT must be a partner in an organization′s efforts to institutionalize quality. A business can begin this effort with several basic steps. Briefly explaining the evolution of the quality movement will help put those steps into context.
Expectant fathersʼ response to pregnancy: Review of literature and implications for research in high-risk pregnancy (1990)

It is evident that couvade syndrome exists in the industrialized culture. However, there are questions about the occurrence of couvade given the large range of reported incidence. Clinton found no difference in the occurrence of symptoms between expectant fathers and nonexpectant men throughout the three trimesters of pregnancy. Differences were noted, however, in the types and perceived seriousness of symptoms between these men, with expectant fathers reporting more colds, unintentional weight gain, insomnia, and restlessness. Significant differences in health deviation were reported by the new fathers during the immediate postpartum period. These new fathers experienced fatigue, emotional and cognitive disturbances, and headaches. Strickland's work did not provide comparative estimates of the incidence of couvade syndrome. The focus of this study was to explore the nature of pregnancy-related symptoms among expectant fathers. These expectant fathers reported key symptoms during the second trimester of pregnancy with increasing occurrence during the last trimester of pregnancy. Expectant fathers most likely to experience couvade were anxious, black, working class men experiencing an unplanned pregnancy. Anxiety, suppression of hostility, and identification with the pregnant partner were explored as predictors of the occurrence of couvade syndrome. Anxiety is likely to occur in expectant fathers because of financial concerns and changes in relationships and roles. Feelings of protectiveness toward the partner and fetus/infant also can be anxiety producing for the expectant father. The developmental tasks described by Duvall and Penticuff were predicated on the transitional nature of becoming a parent. Each task depicts the inherent change in both structure and function of the male's family role which is influenced by society and the family unit. May proposed that expectant fathers have unique styles that predict the degree of involvement with the partner and the pregnancy. Phases of father involvement, described by May, and the father's laboring for relevance, described by Jordan, are conceptually consistent with the developmental tasks identified by Duvall. Each phase or subprocess is sequential, marked by intrapersonal and interpersonal characteristics. Movement through these tasks, phases, or subprocesses is dependent upon accepting the reality of the pregnancy, cultural norms, and society's expectations of fathers. Herzog identified degrees of involvement among fathers whose partners delivered prematurely. In this retrospective inquiry, fathers with a high degree of involvement were more likely to experience symptoms of couvade syndrome than were fathers who were less involved. All fathers in the study, regardless of the involvement, reported being fearful of the unknown outcome and experiencing grief over the preterm delivery.(ABSTRACT TRUNCATED AT 400 WORDS)
Design of multi-purposed roll-to-roll printing system for printed electronics (2011)

Compact-sized printing machine with the capability of various printing methods in one printing unit is proposed. The printing method is changeable to gravure, gravure-offset, or flexo by alternating the web path and printing rollers. The machine also has multiple printing units with register control for the multilayer printings. The developed machine is used for the fabrication of printed electronics devices by using the several printing methods, and for the optimization and evaluation of inks.
The isolation and characterization of acetylcholine-containing particles from brain (1959)

Research Article| August 01 1959 The isolation and characterization of acetylcholine-containing particles from brain V P Whittaker V P Whittaker 1Agricultural Research Council Institute of Animal Physiology, Babraham, Cambridge Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1959) 72 (4): 694–706. https://doi.org/10.1042/bj0720694 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation V P Whittaker; The isolation and characterization of acetylcholine-containing particles from brain. Biochem J 1 August 1959; 72 (4): 694–706. doi: https://doi.org/10.1042/bj0720694 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1959 CAMBRIDGE UNIVERSITY PRESS1959 Article PDF first page preview Close Modal You do not currently have access to this content.
Resonant capacitive MEMS acoustic emission transducers (2006)

We describe resonant capacitive MEMS transducers developed for use as acoustic emission (AE) detectors, fabricated in the commercial three-layer polysilicon surface micromachining process (MUMPs). The 1 cm square device contains six independent transducers in the frequency range between 100 and 500 kHz, and a seventh transducer at 1 MHz. Each transducer is a parallel plate capacitor with one plate free to vibrate, thereby causing a capacitance change which creates an output signal in the form of a current under a dc bias voltage. With the geometric proportions we employed, each transducer responds with two distinct resonant frequencies. In our design the etch hole spacing was chosen to limit squeeze film damping and thereby produce an underdamped vibration when operated at atmospheric pressure. Characterization experiments obtained by capacitance and admittance measurements are presented, and transducer responses to physically simulated AE source are discussed. Finally, we report our use of the device to detect acoustic emissions associated with crack initiation and growth in weld metal.
Crowd Behavior Representation Using Motion Influence Matrix for Anomaly Detection (2013)

In this paper, we propose a new method to detect abnormal behavior in crowd video. The motion influence matrix is proposed to represent crowd behaviors. It is generated based on concept of human perception with block-level motion vectors which describe actual crowd movement. Furthermore, a generalized framework is developed to detect abnormal crowd behavior using motion influence matrix. The proposed method has an advantage of that does not require any human detection or segmentation method which make it robust to human detection error by using optical flows which is extracted from two continuous frames. In this model, a normal behavior is presented by a low motion influence value. On the other hand, a high motion influence value indicates occurrence of abnormal behavior. Spatio-temporal cuboids are extracted from the motion influence matrix to measure the unusualness of the frame. Two different kinds of abnormal behaviors are dealt in this research: global abnormal behavior and local abnormal behavior. For t quantitative measurement of effectiveness of the proposed method, we evaluate our algorithm on two datasets: UMN and UCSD for global and local abnormal behavior, respectively. Experimental results show that the proposed method outperforms the competing methods.
Selective epitaxy base transistor (SEBT) (1988)

A bipolar transistor using selective epitaxy for base formation in a double-poly self-aligned structure is presented. The intrinsic base was formed by a selective-epitaxial deposition in place of ion implantation. Such epitaxial base processes are capable of achieving a narrow intrinsic base sheet resistance R/sub bi/ and base-emitter diffusion capacitance c/sub be/ compared to advanced ion-implanted processes. A selective epitaxial base can be simply introduced in advanced double-poly self-aligned processes compared to a nonselective epitaxial layer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Human prostate carcinoma cell lines secrete GM-CSF and express GM-CSF-receptor on their cell surface. (1996)

Using specific ELISA kits, we investigated the secretion of cytokines in five human prostate carcinoma cell lines: ALVA 31, DU145, LNCaP, ND1 and PC3. Three of the five cell lines investigated secreted granulocyte-macrophage colony-stimulating factor (GM-CSF); GM-CSF was not identified in ALVA31 or LNCaP. In addition, we have shown that conditioned media of DU145, ND1 and PC3 stimulated proliferation of the GM-CSF-dependent cell line MO7e indicating that these cells secrete biologically active GM-CSF. By flow cytometric analysis we determined that all five cell lines expressed the alpha-subunit of the GM-CSF receptor on the cell surface but only ALVA31 expressed both the alpha- and beta-subunits of the GM-CSF receptor. Varying concentrations of GM-CSF did not stimulate the proliferation rate of any of the prostate carcinoma cell lines. Thus, there does not appear to be autocrine loop of GM-CSF-induced proliferation. However, the expression of E-cadherin and endoglin (CD105) was modulated under GM-CSF treatment in ALVA31. In addition, GM-CSF decreased the level of soluble CD44 in ND1. These results suggest that the GM-CSF receptor alpha-subunit may play a role in metabolic activity of prostate cancer.
Integrin αvβ1 Is an Adenovirus Coreceptor (2001)

The human embryonic kidney (HEK293) cell line, commonly used for recombinant adenovirus (Ad) propagation, does not express the Ad coreceptor alpha(v)beta3 or alpha(v)beta5 integrins, yet these cells are efficiently infected by Ad vectors. Here we demonstrate that Ad binds to HEK293 cells via the fiber receptor CAR and is subsequently internalized via interaction with integrin alpha(v)beta1. Function-blocking antibodies directed against alpha(v) or beta1, but not beta3, beta5, or alpha5, integrin subunits block Ad infection and viral endocytosis. Therefore, alpha(v)beta1 serves as a coreceptor for Ad infection, and the lack of beta3 and/or beta5 but the relatively high expression of alpha(v)beta1 integrins on certain tumor cell types may explain why these cells are readily transduced by Ad vectors.
Pharmacokinetics of propofol in mixed-breed dogs and Greyhounds (1993)

Pharmacokinetics and recovery characteristics of propofol in Greyhounds and mixed-breed dogs were compared. In all dogs, disposition of propofol was adequately described by a 2-compartment open model, with a rapid distribution phase followed by a slower elimination phase. When findings in Greyhounds were compared with those in mixed-breed dogs, significant differences were observed in mean concentrations of propofol in blood, recovery characteristics, and estimates for apparent volume of distribution, volume of distribution at steady state, and total body clearance. In addition, Greyhounds recovered from anesthesia at higher concentrations of propofol than did mixed-breed dogs. A secondary peak in blood propofol concentration was observed in 8 of 10 Greyhounds and in 5 of 8 mixed-breed dogs. This peak corresponded to the time of return of the righting reflex.
Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunologic Perspectives (2004)

The endocrine system and the immune system interact closely during implantation and maintenance of pregnancy. One of the most striking examples of this communication is at the level of the decidua (endometrium of pregnancy). Here, under the influence of sex steroids, there is a dramatic increase of a unique population of lymphocytes, the uterine natural killer (uNK) cells, in early pregnancy. These cells derive predominantly from a subset of peripheral blood NK cells, which under hormonal influence gets recruited to the uterus. In mice, uNK cells play an important role in the development of placental vasculature. The role of these cells in human pregnancy is still not definitively established; however, they are believed to promote placental and trophoblast growth and provide immunomodulation at the maternal-fetal interface. In contrast to their presumptive role in the maintenance of a healthy pregnancy, uNK cells and peripheral NK cells are dysregulated in unexplained recurrent pregnancy loss. Herein, we review NK cell populations, their changes in number and function in altered endocrine environments during the menstrual cycle and pregnancy, the current data on their potential role in unexplained recurrent pregnancy loss, and mechanisms for potential therapies targeted to NK cell function for this enigmatic disorder.
Synthesis of chaminic acid (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of chaminic acidWalter J. Gensler and Philippa Heggs SolomonCite this: J. Org. Chem. 1973, 38, 9, 1726–1731Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://pubs.acs.org/doi/10.1021/jo00949a024https://doi.org/10.1021/jo00949a024research-articleACS PublicationsRequest reuse permissionsArticle Views773Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lipid Content and Composition of Antarctic Krill, Euphausia Superba Dana (1984)

Available data on the lipid content and composition of the Antarctic krill Euphausia superba Dana are summarized. Female total lipid content increases during the summer as the ovary matures, and there is also some evidence of an increase in the lipid content of males and immatures as winter approaches. The storage lipid is mainly triacylglycerol and there is less than 1% wax ester. Fatty acids are moderately unsaturated, though less so in the ovarian lipid, and the triacylglycerol contains up to 4% phytanic acid. These data suggest that krill feed on phytoplankton during the summer bloom, but that, unlike E. crystallorophias, E. superba does not rely on a lipid store to survive the winter.
Delivery of protein to the cytosol of macrophages using <i>Escherichia coli</i> K‐12 (1999)

Listeriolysin O (LLO) is an essential determinant of pathogenicity whose natural biological role is to mediate lysis of Listeria monocytogenes containing phagosomes. In this study, we report that Escherichia coli expressing cytoplasmic recombinant LLO can efficiently deliver co-expressed proteins to the cytosol of macrophages. We propose a model in which subsequent or concomitant to phagocytosis the E. coli are killed and degraded within phagosomes causing the release of LLO and target proteins from the bacteria. LLO acts by forming large pores in the phagosomal membrane, thus releasing the target protein into the cytosol. Delivery was shown to be rapid, within minutes after phagocytosis. Using this method, a large enzymatically active protein was delivered to the cytosol. Furthermore, we demonstrated that the E. coli/LLO system is very efficient for delivery of ovalbumin (OVA) to the major histocompatibility (MHC) class I pathway for antigen processing and presentation, greater than 4 logs compared with E. coli expressing OVA alone. Moreover, the time required for processing and presentation of an OVA-derived peptide was similar to that previously reported when purified OVA was introduced directly into the cytosol by other methods. Using this system, potentially large amounts of any protein that can be expressed in E. coli can be delivered to the cytosol without protein purification. The potential use of this system for the delivery of antigenic protein in vivo and the delivery of DNA are discussed.