gebhart/patrepeval huggingface dataset:
Efficient sequence detection for intersymbol interference channels with run-length constraints (1994)

This paper addresses the data detection problem of intersymbol interference (ISI) channels with a specific modulation code-constraint known as the (d, k) run-length-limited (RLL) constraint, a popular modulation code-constraint for data storage channels as well as certain communication channels. A computationally efficient sequence detection algorithm is proposed which yields a performance close to that of the maximum likelihood sequence detector when applied to such ISI channels. The proposed detector is derived as a high signal-to-noise ratio approximation to the delay-constrained optimum detector, one which minimizes the symbol error probability given a fixed decision-delay constraint. The proposed algorithm is essentially a fixed-delay tree search (FDTS) algorithm with systematic ambiguity checking and is closely related to existing finite-depth tree search algorithms. It is observed that long critical error events common in uncoded ISI channels are eliminated by the RLL constraint. Based on this observation, we show that for some important RLL constrained channels, the proposed FDTS algorithm yields the same minimum Euclidean distance between distinguishable channel output sequences as the unconstrained maximum likelihood sequence detector.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Colloidal Synthesis of Infrared-Emitting Germanium Nanocrystals (2009)

In this study, we synthesized Ge nanocrystals and studied the effects of variables such as solvents, reducing agents, reaction temperature, and capping ligands. The resulting nanocrystals showed infrared photoluminescence with quantum yields as high as approximately 8% and enhanced resistance to oxidation. Size analysis of the samples by transmission electron microscopy revealed that the size dependence of the emission is consistent with the effects of quantum confinement.
Dynamic optical projection of acquired luminescence for aiding oncologic surgery (2013)

Optical imaging enables real-time visualization of intrinsic and exogenous contrast within biological tissues. Applications in human medicine have demonstrated the power of fluorescence imaging to enhance visualization in dermatology, endoscopic procedures, and open surgery. Although few optical contrast agents are available for human medicine at this time, fluorescence imaging is proving to be a powerful tool in guiding medical procedures. Recently, intraoperative detection of fluorescent molecular probes that target cell-surface receptors has been reported for improvement in oncologic surgery in humans. We have developed a novel system, optical projection of acquired luminescence (OPAL), to further enhance real-time guidance of open oncologic surgery. In this method, collected fluorescence intensity maps are projected onto the imaged surface rather than via wall-mounted display monitor. To demonstrate proof-of-principle for OPAL applications in oncologic surgery, lymphatic transport of indocyanine green was visualized in live mice for intraoperative identification of sentinel lymph nodes. Subsequently, peritoneal tumors in a murine model of breast cancer metastasis were identified using OPAL after systemic administration of a tumor-selective fluorescent molecular probe. These initial results clearly show that OPAL can enhance adoption and ease-of-use of fluorescence imaging in oncologic procedures relative to existing state-of-the-art intraoperative imaging systems.
228. Studies in the azole series. Part XIV. A new synthesis of purines (1949)

A. H. Cook, A. C. Davis, I. Heilbron and G. H. Thomas, J. Chem. Soc., 1949, 1071 DOI: 10.1039/JR9490001071
Design and construction of an environmental SEM (part 4) (1990)

Abstract A new detection configuration using the gaseous detector device in the environmental scanning electron microscope (ESEM) is demonstrated. First, the pressure‐limiting aperture (PLA1) is used simultaneously as a biased electrode to collect the ionization current produced in the gaseous environment of the microscope. Second, a wire electrode is placed above the pressure‐limiting aperture, and it is shown that enough signal from the specimen escapes through the aperture to produce satisfactory images. These detection configurations allow the use of high specimen chamber pressures.
Structure and chromosomal localization of the murine gene encoding GLYCAM 1. A mucin-like endothelial ligand for L selectin. (1993)

We recently described the molecular cloning of a murine cDNA encoding an endothelial cell surface ligand for the leukocyte adhesion molecule, L Selectin (Lasky, L. A., Singer, M., Dowbenko, D., Ima, Y., Henzel, W., Grimley, C., Gennie, C., Gillett, N., Watson, S., and Rosen, S. D (1992) Cell 69, 927-938). This glycoprotein ligand was found to resemble mucins in that it contained a large percentage of serine and threonine residues that were apparently O-glycosylated. At least one of the O-linked carbohydrates found on this endothelial ligand interacts with the lectin domain of L Selectin. These data suggest that this endothelial ligand is an adhesion molecule that accomplishes cell binding by presenting carbohydrate(s) to the lectin domain of L Selectin, and the name GLYCAM 1 (GLY-cosylation-dependent Cell Adhesion Molecule 1) has been proposed. In this paper we describe the genomic structure and chromosomal localization of this unique Selectin ligand. The gene has been found to be encoded on four separate exons, and it thus differs from the cell surface mucin leukosialin, whose coding region is contained on one exon, but is similar to glycophorin and CD34, other cell surface mucins whose genes are divided into multiple coding exons. While there is some correlation between exon division and protein domain structure, these relationships are not as clear as they are in other genes. The gene encoding GLYCAM 1 was found to map to murine chromosome 15.
C1‐inhibitor concentrate for individual replacement therapy in patients with severe hereditary angioedema refractory to danazol prophylaxis (2009)

In patients with severe HAE who experience severe side effects and/or lack of efficacy of danazol prophylaxis, very early substitution with pC1-INH can completely abolish the incidence of potentially fatal laryngeal edema and can reduce the incidence of acute attacks.
Onboard Autonomous Integrity Monitoring using Intersatellite Links (2000)

Between 1981 and 1988 inclusive, 22 patients with full-thickness rectal prolapse presenting to two surgeons in this hospital were treated using the Délorme operation. There was no mortality and morbidity was minimal. Twenty-one patients (95.5%) were cured of prolapse and 19 patients (86.4%) had normal anal sphincter function after the operation.
关于《罗莎·卢森堡全集》英文版的编辑和出版 (2015)

如果没有对卢森堡贡献的多维性——作为理论家、活动家及其独特的人格——的认识，就很难翻阅，更别说研究她的著作了。罗莎·卢森堡（Rosa Luxemburg）曾这样说道，“我感觉到，简言之，如同瓦迪斯瓦夫·海涅（Wladyslaw Heine）所说的一种‘说点有分量的东西’的需要……我觉得我的体内有一个正在成长的新鲜而别致的消解了寻常公式和模式的形式……我确信那里有些什么，必定有些什么即将诞生。”
Mycobacterium avium intracellulare complex causing olecranon bursitis and prosthetic joint infection in an immunocompromised host (2015)

This patient was informed and agreed to the publication of this material.
Bile pigment studies. Part 4. Some novel reactions of metalloporphyrins with thallium(III) and cerium(IV) salts. Ring cleavage of meso-tetraphenylporphyrin (1978)

Treatment of zinc(II)meso-tetraphenylporphyrin (5) with thallium(III) trifluoroacetate or nitrate, or cerium(IV) ammonium nitrate gives a mixture of the 5,15-dihydroxy-5,10,15,20-tetraphenylporphodimethenes (7), the 5-hydroxy-15-methoxy-derivatives (8), and the ring-opened bilinone (10) after acidic demetallation. An extra product when thallium(III) trifluoroacetate is employed is the trifluoroacetyl derivative (12) or (13). When thallium(III) nitrate or cerium(IV) ammonium nitrate are used, the β-nitro-meso-tetraphenylporphyrin (14) is also isolated. Nitration of zinc(II) octa-alkylporphyrins with these two salts is shown to be a general reaction which can be controlled to give mono- or di-nitration at the meso-positions. Mechanistic implications of the ring-cleavage and nitration reactions are discussed.
Deficient SOCS3 expression in CD4<sup>+</sup>CD25<sup>+</sup>FoxP3<sup>+</sup> regulatory T cells and SOCS3‐mediated suppression of Treg function (2007)

Naturally occurring CD4+CD25+FoxP3+ regulatory T cells (Treg) suppress T helper (Th) cell-mediated immune responses. The cytokines IL-2 and IL-6 are known to influence Treg function. However, their relative effects on Th cells versus Treg are not well understood. Stimulation with IL-2, and to a lesser extent, IL-6, enhanced Treg proliferation, FoxP3 and CTLA4 maintenance, and suppressive function. In contrast, when IL-2 or IL-6 were added to Treg/Th cell cocultures, suppression was inhibited. The molecule SOCS3 negatively regulates responses to IL-2 and IL-6. Interestingly, unlike Th cells, Treg were found to be deficient in SOCS3 protein expression. The significance of this finding lies in the need for Treg to rapidly respond to these cytokines to prevent unwarranted immune responses to self-antigens. Overexpression of SOCS3 in Treg decreased their proliferation, FoxP3 and CTLA-4 expression and suppressive function. Thus, up-regulation of SOCS3 expression may be a useful therapeutic approach in diseases where inhibition of Treg is desirable.
[Protective effect of daizein on apoptosis cells of nasal mucosas in ovariectomized rats]. (2003)

Estrogen replacement and daizein might have effects on protecting cells of mucosas from lacking of estrogen by decreasing apoptosis cells in ovariectomized rats.
Analysis of the SlyA‐controlled expression, subcellular localization and pore‐forming activity of a 34 kDa haemolysin (ClyA) from <i>Escherichia coli</i> K‐12 (1999)

Escherichia coli K-12 harbours a chromosomal gene, clyA (sheA, hlyE), that encodes a haemolytic 34 kDa protein. Recombinant E. coli overexpressing the cloned clyA gene accumulated this haemolysin in the periplasm and released only very small amounts of it into the external medium. The secretion of ClyA was confined to the log phase and paralleled by the partial release of several other periplasmic proteins. Sequencing of ClyA revealed the translational start point of the clyA gene and demonstrated that the clyA gene product is not N-terminally processed during transport. The transcription of clyA from its native promoter region was positively controlled by SlyA, a regulatory protein found in E. coli, Salmonella typhimurium and other Enterobacteriaceae. SlyA-controlled transcription started predominantly 72 bp upstream from clyA, as shown by primer extension. The corresponding putative promoter contains an unusual -10 sequence (TATGAAT) that is separated from a conventional -35 sequence by a GC-rich spacer. Site-directed deletion of the G in the -10 sequence abrogated the SlyA requirement for strong ClyA production, whereas a reduction in the G + C content of the spacer diminished the capability of SlyA to activate the clyA expression. Osmotic protection assays and lipid bilayer experiments suggested that ClyA forms stable, moderately cation-selective transmembrane pores that have a diameter of about 2.5-3 nm.
Asymmetric homogeneous hydrogenation catalyzed by a cobalt complex. High enantiomeric excess via statistically designed experiments and mechanistic studies (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric homogeneous hydrogenation catalyzed by a cobalt complex. High enantiomeric excess via statistically designed experiments and mechanistic studiesRichard W. Waldron and James H. WeberCite this: Inorg. Chem. 1977, 16, 5, 1220–1225Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://doi.org/10.1021/ic50171a049Request reuse permissionsArticle Views182Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (851 KB) Get e-Alertsclose Get e-Alerts
Excision of uracil residues in DNA: mechanism of action of<i>Escherichia coli</i>and<i>Micrococcus luteus</i>uracil-DNA glycosylases (1985)

Various octadeoxynucleotides containing uracil at different positions were synthesized and submitted to the action of Escherichia coli and Micrococcus luteus uracil-DNA glycosylases. A uracil residue situated at the 5'-end was excised by the M.luteus enzyme but not by the E.coli one. Uracil residues located at the ultimate and penultimate positions at the 3'-end were not cleaved by either enzymes. At the other central positions, uracil was eliminated with different initial velocities. Single stranded phi X 174 DNA fragments were used to study the influence of the sequence. Cytosine bases were deaminated to give uracil by bisulfite treatment. It was shown that the initial excision velocity of two vicinal uracil residues was decreased. The same observation was made for two uracils separated by one base. A hypothetical scheme is suggested to explain the mechanism of action of uracil-DNA glycosylases.
Gastric lesions in transforming growth factor beta-1 heterozygous mice. (1996)

Transforming growth factor beta-1 (TGF beta 1) is known to inhibit the growth of many epithelial cell types in culture. Consequently, it is important to determine whether it has any tumor suppressor activity in vitro. Fifteen heterozygous and eight wild type TGF beta 1-deficient mice were examined to determine if there was a difference in lifespan or lesion development due to the loss of one TGF beta 1 allele. Mice were killed when there was evidence of neoplasia or severe illness. There was no significant difference in the lifespan of the two groups. Hyperplastic lesions in the glandular mucosa were seen in 10 TGF beta 1 (+/-) mice. These lesions were localized to the lesser curvature of the stomach, extending from the limiting ridge to the pylorus. Seven of the 10 glandular hyperplastic lesions in the TGF beta 1 (+/-) mice had features similar to human gastritis cystica profunda. Associated with the glandular invasion of the muscularis were a mixed inflammatory infiltration of the surrounding muscular wall and mucosa with chronic vasculitis in the tissues adjacent to these lesions. In contrast to the distinct genotypic differences in lesion incidence observed in the glandular stomach, there was no significant difference in lesion incidence in other organs. The increased incidence of the hyperplastic lesions in the TGF beta 1 (+/-) mice is highly suggestive that allelic loss of TGF beta 1 plays an important role in the genesis of these lesions. However, allelic loss of TGF beta 1 does not cause alterations in the incidence of neoplasia.
DNA Methylation at Mammalian Replication Origins (1999)

In Escherichia coli, DNA methylation regulates both origin usage and the time required to reassemble prereplication complexes at replication origins. In mammals, at least three replication origins are associated with a high density cluster of methylated CpG dinucleotides, and others whose methylation status has not yet been characterized have the potential to exhibit a similar DNA methylation pattern. One of these origins is found within the approximately 2-kilobase pair region upstream of the human c-myc gene that contains 86 CpGs. Application of the bisulfite method for detecting 5-methylcytosines at specific DNA sequences revealed that this region was not methylated in either total genomic DNA or newly synthesized DNA. Therefore, DNA methylation is not a universal component of mammalian replication origins. To determine whether or not DNA methylation plays a role in regulating the activity of origins that are methylated, the rate of remethylation and the effect of hypomethylation were determined at origin beta (ori-beta), downstream of the hamster DHFR gene. Remethylation at ori-beta did not begin until approximately 500 base pairs of DNA was synthesized, but it was then completed by the time that 4 kilobase pairs of DNA was synthesized (<3 min after release into S phase). Thus, DNA methylation cannot play a significant role in regulating reassembly of prereplication complexes in mammalian cells, as it does in E. coli. To determine whether or not DNA methylation plays any role in origin activity, hypomethylated hamster cells were examined for ori-beta activity. Cells that were >50% reduced in methylation at ori-beta no longer selectively activated ori-beta. Therefore, at some loci, DNA methylation either directly or indirectly determines where replication begins.
A co-channel interference cancellation technique using orthogonal convolutional codes (1996)

This paper proposes a new parallel co-channel interference cancellation technique which utilizes orthogonal convolutional codes. Co-channel interference (CCI) limits the performance of a spread spectrum multiple access communication link. Several CCI cancellation techniques have been proposed to remove this interference. Of particular interest are techniques which do not require the receiver to have knowledge of the cross-correlation between user sequences. These techniques reconstruct the CCI based on the initial decisions regarding the signals from the other users. However, these techniques leave residual interference after cancellation caused by errors in these initial decisions. To improve the initial decisions and reduce the residual interference, our proposed scheme utilizes the error correcting capability of orthogonal convolutional codes. This paper evaluates the performance of this scheme. We show that, given a processing gain of 128 for up to about 40 users, the performance of the proposed CCI canceller approaches the performance of a system without multi-user interference. We also show that the proposed CCI canceller offers an improvement in capacity by a factor of 1.5/spl sim/3 over that of a conventional canceller.
Wiring neurons with carbon nanotubes (2009)

GENERAL COMMENTARY article Front. Neuroeng., 29 May 2009 https://doi.org/10.3389/neuro.16.008.2009
Infrared Spectra of Monoterpenes and Related Compounds. II. Terpene Alcohols (1968)

The infrared spectra of 141 highly purified acyclic, monocyclic and bicyclic terpene alcohols, their reduced derivatives, and related compounds are presented. The majority of these spectra are new to the literature. These spectra provide a broad basis for the correlation of structure and infrared absorption.
Identification of an Enzyme System for Daidzein-to-Equol Conversion in Slackia sp. Strain NATTS (2011)

An Escherichia coli library comprising 8,424 strains incorporating gene fragments of the equol-producing bacterium Slackia sp. strain NATTS was constructed and screened for E. coli strains having daidzein- and dihydrodaidzein (DHD)- metabolizing activity. We obtained 3 clones that functioned to convert daidzein to DHD and 2 clones that converted DHD to equol. We then sequenced the gene fragments inserted into plasmids contained by these 5 clones. All of the gene fragments were contiguous, encoding three open reading frames (ORF-1, -2, and -3). Analysis of E. coli strains containing an expression vector incorporating one of the orf-1, -2, or -3 genes revealed that (i) the protein encoded by orf-1 was involved in the conversion of cis/trans-tetrahydrodaidzein (cis/trans-THD) to equol, (ii) the protein encoded by orf-2 was involved in the conversion of DHD to cis/trans-THD, and (iii) the protein encoded by orf-3 was involved in the conversion of daidzein to DHD. ORF-1 had a primary amino acid structure similar to that of succinate dehydrogenase. ORF-2 was presumed to be an enzyme belonging to the short-chain dehydrogenase/reductase superfamily. ORF-3 was predicted to have 42% identity to the daidzein reductase of Lactococcus strain 20-92 and belonged to the NADH:flavin oxidoreductase family. These findings showed that the daidzein-to-equol conversion reaction in the Slackia sp. NATTS strain proceeds by the action of these three enzymes.
CONSTRUCTION OF BELIEF AND DECISION NETWORKS (1992)

We describe a representation and set of inference techniques for the dynamic construction of probabilistic and decision‐theoretic models expressed as networks. In contrast to probabilistic reasoning schemes that rely on fixed models, we develop a representation that implicitly encodes a large number of possible model structures. Based on a particular query and state of information, the system constructs a customized belief net for that particular situation. We develop an interpretation of the network construction process in terms of the implicit networks encoded in the database. A companion method for constructing belief networks with decisions and values (decision networks) is also developed that uses sensitivity analysis to focus the model building process. Finally, we discuss some issues of control of model construction and describe examples of constructing networks.
K-Ras Mutations and Treatment Outcome in Colorectal Cancer Patients Receiving Exclusive Fluoropyrimidine Therapy (2008)

The present data indicate a perfect concordance of K-Ras mutations between primary and liver metastasis and suggest that any predictive and/or prognostic value of K-Ras mutations in treatments combining anti-EGFR monoclonal antibodies with 5-FU should be exclusively linked to the anti-EGFR agent.
The BSCS 5E Instructional Model: Origins and Effectiveness (2006)

s International 36(11): 7368A. Champagne, A. (1987). The psychological basis for a model of science instruction. Commissioned paper for IBM-supported design project. Colorado Springs, CO:
The World Economy (2004)

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