gebhart/patrepeval huggingface dataset:
Production job scheduling for parallel shared memory systems (2002)

This paper addresses open job scheduling questions for the challenge workloads that run on the large scale parallel systems at supercomputer centers. Simulation results for six recent one-month job traces from the NCSA Origin 2000 (O2K) system are used to evaluate (I) the experimentally tuned NCSA LSF* policy, (2) the FCFS-backfill policy, (3) the Priority-backfill policy with alternative priority functions and with limited pre-emption to provide immediate service to each arriving job, and (4) the spatial equipartitioning (EQspatial) policy with an optional modification to reduce the maximum waiting time for the largest jobs in the challenge workloads. Measurements on the O2K validate the simulation results for two of the policies. The priority-backfill policy with immediate service and a starvation-free priority measure that favors short jobs is shown to be the most promising if jobs cannot adapt to changing processor allocations at runtime, but EQspatial provides significantly better 95th percentile waiting time.
Biogeographical Barriers (2005)

Biogeographical barriers serve to limit the geographic range of a species, be it in the ocean or on land. Land barriers to marine migration and marine barriers to land migration are the most easily determined from the geological record; however, temperature can be invoked in both situations. Physiographic features such as mountain ranges can restrict land organisms, and shallow marine organisms may not be able to cross oceans of great depth. Barriers can allow the passage of organisms by three means, in order of greater restriction to migration: 1) corridors; 2) filters; and 3) sweepstakes routes. Examples from the fossil record and recent are given of barriers to marine and continental organisms and their means of overcoming those barriers.
Comparative functional study of the lysyl oxidase promoter in fibroblasts, Ras-transformed fibroblasts, myofibroblasts and smooth muscle cells. (1999)

The promoter activity of lysyl oxidase (LOX), the enzyme involved in collagen and elastin cross-linking and in tumor suppression, was compared in extracellular matrix producing cells and in tumorigenic c-Ha-ras-NIH-3T3 fibroblasts (RS485). The full 2 kb murine LOX promoter was very active in 3T6-5 myofibroblast-like cells (MFLC) and vascular smooth muscle cells (SMC) and was inhibited in ras-transformed fibroblasts. Positive cis-acting elements were located around sites of transcription initiation in MFLC and SMC, but neither in RS485 fibroblasts nor in their non-transformed counterparts. The main positive cis-acting segment, at positions -808 to -585, was active in all cells, with the strongest activity in MFLC and SMC, and one segment, at positions -758 to -726, allowed the formation of one master DNA-protein complex with nuclear factors from all cells. The main inhibiting region, at positions -1,362 to -1,176, was active in all fibroblasts, but not in SMC, in an upstream position or in an enhancer/silencer position. This region carries two segments, called LOcoll and LOcol2 for their similarity to COL1A1 and COL1A2 promoter sequences, that were involved in the formation of a large multifactorial DNA complex with nuclear factors from all cells, though slightly for SMC. Another region, carrying a putative interferon response element (IRF) at positions -898 to -886, acted negatively on each type of cells. In conclusion, the LOX promoter is controlled by cross-talk between positive and negative cis-acting regions that are differentially active in various cells. The -758 to -726 region, with its putative C/EBP site, and the transcription initiation region are likely to play a master role in activating the LOX promoter in fibrocompetent MFLC and SMC. While the LOcol1/2 segment, with putative B-Myb binding sites, and the IRF carrying region, work negatively on the LOX promoter in transformed cells.
Immunohistological determination of oestrogen receptor, progesterone receptor, and intermediate filaments in Leydig cell tumours, Leydig cell hyperplasia, and normal Leydig cells of the human testis (1989)

Testicular Leydig cell tumours are able to produce oestrogens and can be induced by exogeneous oestrogen administration. Oestrogen and progesterone receptors, cytokeratin, vimentin, and proliferative activity were determined immunohistologically in human testes in six Leydig cell tumours, 14 cases of Leydig cell hyperplasia, and 13 cases with normal Leydig cells. While both steroid receptors were detected in about 70 per cent of the tumour cells in cryostat sections, no reaction was observed in normal Leydig cells. This supports the hypothesis of an enhanced receptor state in a Leydig cell subpopulation as a basic pathophysiological factor in the development of Leydig cell tumours. On cryostat sections, all tumours co-express cytokeratin and vimentin. Neither the receptors nor the intermediate filaments could be detected reliably in paraffin sections. The low proliferative activity of Leydig cell tumours corresponds to their benign clinical course.
LSM-tree managed storage for large-scale key-value store (2017)

Key-value stores are increasingly adopting LSM-trees as their enabling data structure in the backend storage, and persisting their clustered data through a file system. A file system is expected to not only provide file/directory abstraction to organize data but also retain the key benefits of LSM-trees, namely, sequential and aggregated I/O patterns on the physical device. Unfortunately, our in-depth experimental analysis reveals that some of these benefits of LSM-trees can be completely negated by the underlying file level indexes from the perspectives of both data layout and I/O processing. As a result, the write performance of LSM-trees is kept at a level far below that promised by the sequential bandwidth offered by the storage devices. In this paper, we address this problem and propose LDS, an LSM-tree based Direct Storage system that manages the storage space and provides simplified consistency control by exploiting the copy-on-write nature of the LSM-tree structure, so as to fully reap the benefits of LSM-trees.
High Efficacy of First-Line Gefitinib in Non-Asian Patients with EGFR-Mutated Lung Adenocarcinoma (2010)

Gefitinib may be considered as an upfront treatment option for EGFR-mutated NSCLC.
Improved Fermentation Processes for NS0 Cell Lines Expressing Human Antibodies and Glutamine Synthetase (2003)

To meet the increasing requirement for therapeutic antibodies to conduct clinical trials, an enhanced culture medium and fed-batch process was developed for GS-NS0 cell lines. This process was shown to produce high concentrations of monoclonal antibodies for several cell lines expressing different antibodies. Cells were adapted to growth in a glutamine- and serum-free medium containing bovine serum albumin (BSA), cholesterol, and transferrin. A number of amino acids were found to be depleted during cell culture. The concentrations of these amino acids were increased, and further cell culture analyses were performed. This process of cell growth and analysis was repeated over multiple cycles until no depletion was detected. This resulted in an amino acid supplement that was shown to be generic and enhanced antibody productivity up to 5-fold for the three cell lines tested. Transferrin was replaced using tropolone, a lipophilic iron chelator and ferric ammonium citrate. Cell growth was equivalent to that in transferrin-containing medium over the wide ranges tested. A concentrated feed solution, based on the amino acid supplement and the components of the serum- and protein-free supplements, was formulated. Addition of this feed in response to metabolic requirements resulted in a harvest titer a further 2-fold higher than the enhanced culture medium. Harvest antibody titers of up to 600 mg/L were achieved for three cell lines expressing different antibodies, representing an increase of 10-fold over the starting concentrations.
Alu transcripts: cytoplasmic localisation and regulation by DNA methylation (1994)

Full length Alu transcripts in HeLa cells are detected by primer extension using reverse transcriptase and are also analyzed as cloned cDNA sequences. The 5' end of these transcripts corresponds to the transcriptional start site for RNA polymerase III indicating that these RNAs are transcribed from their internal polymerase III promoters. The Alu transcripts found in cytoplasmic poly A+ RNAs appear to be organized into RNPs as assayed by sucrose gradient sedimentation. Present at about one hundred to one thousand copies per cell, the Alu transcripts are rare as compared to 7SL RNA. In agreement with previous reports that methylation inhibits Pol III-directed transcription of Alu in vitro, treatment of HeLa cells with 5-azacytidine results in Alu DNA hypomethylation and an increase in the abundance of the Alu transcript. Sequence analysis shows that many different Alu repeats including members of all subfamilies are transcribed by Pol III in vivo. cDNA sequences of the Pol III-directed transcripts exactly match the A box of the Pol III promoter element whereas in other Alu transcripts this element is not faithfully conserved.
Topics in pediatric leukemia--acute myeloid leukemia. (2005)

Acute leukemia is the most common childhood malignancy, representing close to 35% of all childhood cancers. Acute myelogenous leukemia (AML) constitutes 15% to 20% of acute leukemias. There are close to 500 new cases of childhood AML per year in the United States.[1] The incidence reaches a peak at 2 years of age with 12 cases per 1 million people, and a nadir of 3.8 cases per million at 9 years of age. There is another peak after age 16 with close to 9 cases per million.[2,3] Unlike acute lymphoblastic leukemia (ALL), boys and girls are affected equally by AML and disease rates are similar among different racial groups.[4,5]

There are several conditions or external factors that predispose children to develop AML. Environmental exposures include ionizing radiation, chemotherapy (eg, alkylating agents and topoisomerase II inhibitors), and organic solvents.[6] Some hereditary conditions that are associated with a higher incidence of AML include Fanconi's anemia, Diamond-Blackfan syndrome, Li-Fraumeni syndrome, and Down syndrome. Children with Down syndrome have a 15-fold higher incidence of leukemia and are prone to develop a subtype of AML known as acute megakaryocytic leukemia (or M7-AML).[7–9]
Transformation of Clostridium perfringens (1984)

Clostridium perfringens 11268 CDR (Rifr Tcs), the strain transformed in our experiments, was generated by curing a spontaneous, rifampicin-resistant mutant of C. perfringens 11268 (Rifr Tcr). High-temperature growth yielded tetracycline-sensitive, rifampicin-resistant cells which no longer contained pCW3, a 42.8-kilobase plasmid. The tetracycline-sensitive, rod-shaped cell was then converted to an L-phase variant by growth in the presence of penicillin G (10 micrograms/ml) and 0.4 M sucrose. After several passages, the antibiotic was removed from the medium, and cells continued to grow as L-phase variants. Another large plasmid, pJU124 (38.8 kilobases), which confers tetracycline resistance, was used for transformation. Transformation of L-phase variants of C. perfringens 11268 CDR (Rifr Tcs) was mediated by polyethylene glycol. Transformation frequency is a nonlinear function of DNA concentration. Restriction analysis showed that the plasmid isolated from the transformants was identical to that supplied. Stable L-phase variants do not revert to rod-shaped cells, but autoplasts can be both transformed and reverted.
Kids Learning Engineering Science Using LEGO and the Programmable Brick (1996)

With the aim of introducing ideas in engineering science to students at the elementary and high school levels, we have created the “Programmable Brick,” a new educational technology, and collaborated with teachers in the design and assessment of curricular plans for introducing the technology to the classroom. Using the Programmable Brick, students explore a variety of concepts, including sensing, control, and systems. Central to our approach is the belief that children learn most effectively when they are engaged in design, construction, and debugging activities. This paper reports results from a collaboration with three teachers—two elementary, one high school—developing curricular and testing models for introducing these materials to the classroom over the 1994–95 academic year.
Influence of Cellular ERα/ERβ Ratio on the ERα-Agonist Induced Proliferation of Human T47D Breast Cancer Cells (2008)

Breast cancer cells show overexpression of estrogen receptor (ER) alpha relative to ERbeta compared to normal breast tissues. This observation has lead to the hypothesis that ERbeta may modulate the proliferative effect of ERalpha. This study investigated how variable cellular expression ratios of the ERalpha and ERbeta modulate the effects on cell proliferation induced by ERalpha or ERbeta agonists, respectively. Using human osteosarcoma (U2OS) ERalpha or ERbeta reporter cells, propyl-pyrazole-triol (PPT) was shown to be a selective ERalpha and diarylpropionitrile (DPN) a preferential ERbeta modulator. The effects of these selective estrogen receptor modulators (SERMs) and of the model compound E2 on the proliferation of T47D human breast cancer cells with tetracycline-dependent expression of ERbeta (T47D-ERbeta) were characterized. E2-induced cell proliferation of cells in which ERbeta expression was inhibited was similar to that of the T47D wild-type cells, whereas this E2-induced cell proliferation was no longer observed when ERbeta expression in the T47D-ERbeta cells was increased. In the T47D-ERbeta cell line, DPN also appeared to be able to suppress cell proliferation when levels of ERbeta expression were high. In the T47D-ERbeta cell line, PPT was unable to suppress cell proliferation at all ratios of ERalpha/ERbeta expression, reflecting its ability to activate only ERalpha and not ERbeta. It is concluded that effects of estrogen-like compounds on cell proliferation are dependent on the actual ERalpha/ERbeta expression levels in these cells or tissues and the potential of the estrogen agonists to activate ERalpha and/or ERbeta.
Cloning of the non-structural gene 3 of hepatitis C virus and its inducible expression in cultured cells (1999)

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Premunition against Plasmodium falciparum in a malaria hyperendemic village in Myanmar (2001)

Premunition, naturally acquired protective immunity against Plasmodium falciparum, has been described in hyperendemic areas of Africa and Papua New Guinea. However, its occurrence in Asia is debatable. In order to elucidate this question, a longitudinal study was undertaken in Oo-Do, a malaria endemic village in Myanmar [Burma] in 1995-97. Only 2 species, Plasmodium falciparum and P. vivax, were detected, with the former predominating. Data from 116 subjects showed that all were infected at one time or another, over a period of 3 years, with a 38% reinfection rate after eradication of patent parasitaemia. The high rate of prevalence (90-100%) of parasite-specific antibodies in the indirect immunofluorescence antibody test and the presence of the primary vector (Anopheles minimus) and 15 other species of Anopheles throughout the year indicated a high level of transmission. The spleen rate was 70% in 5-9 years old children and was inversely related with age. The incidence of parasitaemia was maximal (49%) in children aged 2-4 years, and then declined marginally with age. There was a significant difference (P = 0.001) between the asymptomatic and febrile parasitaemia levels. Also, malarial episodes occurred more frequently in children than in adults (P = 0.001). Taken together, all these facts indicated that the inhabitants of Oo-Do had progressively developed non-sterile partial protective immunity against P. falciparum malaria, or premunition. To our knowledge, this is the first detailed clinico-epidemiological study to document the occurrence of premunition in Myanmar.
Circuit activity based logic synthesis for low power reliable operations (1993)

A system developed to synthesize both finite state machines and combinational logic for low-power applications, called SYCLOP, is described. SYCLOP tries to minimize the transition density at the internal nodes of a circuit to minimize power dissipation during normal operation. As input signal probabilities and transition densities are considered during the synthesis process, a particular circuit can be synthesized in different ways for different applications that require different types of inputs. For the present state inputs to the combinational circuit of a state machine, simulation was used to determine the signal probabilities and transition densities. The algorithm is not limited by the number of bits used for state assignment. The multilevel optimization process extracts kernels so that there is a balance between area and power optimization. Results have been obtained for a wide range of MCNC benchmark examples.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Anthropometric Comparison of the Idealized Youth and Hideous Old Man of Leonardo’s Profile Drawings (2014)

The aim of this study is to compare the old and ugly with the young and beautiful in Leonardo's profile drawings using soft tissue anthropometry.Thirty-one of Leonardo's profile drawings and portraits of the lateral view were collected and scanned. Among the 29, 9 young and 20 hideous old man scans had a measurable nasion-subnasale (n-sn) distance, and 49 anthropometric items (43 distances and 6 angles) were used for measurement as relative distances to the n-sn distance.The measured distances or angles did not differ significantly between the young and old in the 39 anthropometric items. However, the remaining 10 items were statistically significant. The young group had a significantly greater (P < 0.05) upper face height (n-stomion [sto]), nasolabial angle, and upper lip height (sn-sto) compared with the old group. However, the supraorbital depth (glabella-tragion), mandible height (sto-gnathion), nasal bridge height (n-pronasale), cutaneous lower lip height (labiale inferius-sublabiale), ear length (superaurale-subaurale), Rickett line-upper lip distance, and facial inclination were significantly greater (P < 0.05) in the old group compared with the young group.The difference of soft tissue cephalometric results between the young and old subjects can be the index in rejuvenating surgeries.
SEQUEL 2: A Unified Approach to Data Definition, Manipulation, and Control (1976)

Sequel 2 is a relational data language that provides a consistent, English keyword-oriented set of facilities for query, data definition, data manipulation, and data control. Sequel 2 may be used either as a stand-alone interface for nonspecialists in data processing or as a data sublanguage embedded in a host programming language for use by application programmers and data base administrators. This paper describes SEQUEL 2 and the means by which it is coupled to a host language.
Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics (2012)

Propylene glycol is an aliphatic alcohol that functions as a skin conditioning agent, viscosity decreasing agent, solvent, and fragrance ingredient in cosmetics. Tripropylene glycol functions as a humectant, antioxidant, and emulsion stabilizer. Polypropylene glycols (PPGs), including PPG-3, PPG-7, PPG-9, PPG-12, PPG-13, PPG-15, PPG-16, PPG-17, PPG-20, PPG-26, PPG-30, PPG-33, PPG-34, PPG-51, PPG-52, and PPG-69, function primarily as skin conditioning agents, with some solvent use. The majority of the safety and toxicity information presented is for propylene glycol (PG). Propylene glycol is generally nontoxic and is noncarcinogenic. Clinical studies demonstrated an absence of dermal sensitization at use concentrations, although concerns about irritation remained. The CIR Expert Panel determined that the available information support the safety of tripropylene glycol as well as all the PPGs. The Expert Panel concluded that PG, tripropylene glycol, and PPGs ≥3 are safe as used in cosmetic formulations when formulated to be nonirritating.
Design of semiconductor photoelectrochemical systems for solar energy conversion (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign of semiconductor photoelectrochemical systems for solar energy conversionAllen J. BardCite this: J. Phys. Chem. 1982, 86, 2, 172–177Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/j100391a008https://doi.org/10.1021/j100391a008research-articleACS PublicationsRequest reuse permissionsArticle Views2316Altmetric-Citations374LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Adherence to topical treatment in psoriasis: a systematic literature review (2012)

Literature data about topical treatment adherence are heterogeneous and scarce. They confirm the limited topical treatment adherence in psoriasis in real life, much lower than what is reported in randomized controlled trials. Therapeutic education and clear instructions on the use of topical agents are necessary to improve adherence. Studies are needed to identify predictors of limited adherence and to identify interventions improving adherence to topical medications in psoriasis.
Application of mild acetolysis to confirm the comb-like structure of cell wall mannan from Pichia pastoris IFO0948 strain. (1988)

In order to confirm the chemical structure of the mannan of Pichia pastoris IFO 0948 strain, which was assumed to possess a highly branched comb-like structure, a sequential degradation procedure involving partial acid hydrolysis followed by acetolysis under mild conditions was employed. This procedure can widely be adopted as a method for determining the structural shape of fungal mannans possessing a highly branched structure, either comb-like or tree-like, without application of enzymolytic degradation.
Investigation of magnesium fluoride crystals for imaging acousto-optic tunable filter applications (2006)

Results of an investigation of acousto-optic (AO) cells using single crystals of magnesium fluoride (MgF2) are presented. Two acousto-optic tunable filter (AOTF) cells for imaging application have been designed and tested in the visible and ultraviolet (UV) regions of the spectrum from 190 to 490 nm. The two imaging filters were developed by using the wide-angle AO interaction geometry in the (010) and (11 0) planes of the crystal. These filters were used to obtain spectral images at the shortest wavelengths achieved so far. Advantages and drawbacks of this crystal are discussed and photoelastic, acoustic, and AO properties of MgF2 are examined. The investigation confirmed that MgF2-based AOTF cells can be used in the deep UV region up to 110 nm.