gebhart/patrepeval huggingface dataset:
Experimental Evaluation of the Cloud-Native Application Design (2015)

Cloud-Native Applications (CNA) are designed to run on top of cloud computing infrastructure services with inherent support for self-management, scalability and resilience across clustered units of application logic. Their systematic design is promising especially for recent hybrid virtual machine and container environments for which no dominant application development model exists. In this paper, we present a case study on a business application running as CNA and demonstrate the advantages of the design experimentally. We also present Dynamite, an application auto-scaler designed for containerised CNA. Our experiments on a Vagrant host, on a private OpenStack installation and on a public Amazon EC2 testbed show that CNA require little additional engineering.
High density multi-fiber connector for optical interconnection (2008)

Novel extremely small multi-fiber connectors for optical interconnection systems are designed, fabricated, and evaluated. It has low insertion loss and excellent environmental endurance. It meets the requirement of higher integration in optical backplane systems.
ChemInform Abstract: SULFATION OF CERIA (CEO2) AND ZIRCONIA (ZRO2) RELATING TO HOT CORROSION (1985)

Abstract Untersuchungen des Sulfatisierungsverhaltens von CeOzund ZrOQ zeigen, daß CeO 2 dem Y 2 O 3 bez. einer Verbesserung der Heißkorrosionsbeständigkeit von Zrüz‐Beschichtungen überlegen ist.
Preparation and properties of inverse perovskite Mn3GaN thin films and heterostructures (2013)

Thin films and heterostructures of Mn3GaN with an inverse perovskite structure were grown epitaxially on SrTiO3 (001) and (La0.18Sr0.82)(Al0.59Ta0.41)O3 (001) (LSAT) substrates by ion beam sputtering, and their structural and electrical properties have been investigated. Mn3GaN epitaxial thin films showed metallic behavior of temperature-dependent resistivity with a small maximum at 290–340 K. The maximum resistivity could be attributed to the magnetic transition from antiferromagnetism to paramagnetism. It has been found that epitaxial heterostructures formed by ferroelectric Ba0.7Sr0.3TiO3 and Mn3GaN layers exhibit a large magnetocapacitance effect of more than 2000% in an applied magnetic filed of 1.5 T.
An electrochemical impedance spectroscopic study of the electronic and ionic transport properties of LiCoO2 cathode (2007)

第一 delithiation-lithiation ofLiCoO_2 阴极的存储行为和过程被电气化学的阻抗光谱学(EIS ) 调查。与电极电位的变化一起的 LiCoO_2 阴极的电子、离子的运输性质在 1 mol-L~ 被获得(-1) LiPF_6-EC : 直接数字控制：DEC 电解质答案。在在电解质答案的 LiCoO_2 阴极的 9 hstorage 以后，一条新弧在 EIS 的 Nyquist 阴谋出现在中等频率范围，这被发现，它与增加存储时间增加。在 thecharge/discharge 过程，新弧的直径 reversi-bly 与电极电位被改变。如此的变化与 theLiCoO_2 的电子电导率的电极电位依赖与一致很好。因此，这个新 EIS 特征在电解质答案，以及在锂离子的 intercalation-deintercalationtion 的过程在 LiCoO_2 阴极的存储期间被归因于 Li_xCoO_2 的电子电导率的变化。SEI 的抵抗的可逆增加和减少在费用分泌物拍摄过程，这被揭示了能也被归功于到 LiCoO_2 阴极的活跃材料的电子传导力的变化。
Efficacy of once daily nitrendipine in mild hypertension: comparison with placebo. (1991)

A randomized, double-blind, parallel group study was carried out to compare the antihypertensive efficacy of nitrendipine with that of placebo in 80 mild hypertensives. The dose of nitrendipine was initially 10 mg once daily and was doubled to 20 mg once daily after four weeks in patients who responded poorly (33% of patients on nitrendipine and 49% of patients on placebo required doubling of dose). Blood pressure was assessed 20 to 24 h after dosing. Mean (+/- standard error) reductions in supine systolic and diastolic blood pressures for patients who completed 10 weeks of therapy were significantly greater for the nitrendipine group than for the placebo group (systolic blood pressure 18.1 +/- 2.7 mmHg versus 4.2 +/- 2.5, P less than 0.0001; and diastolic blood pressure 10.6 +/- 1.1 mmHg versus 6.6 +/- 1.3, P = 0.002). A comparison of mean reductions in standing systolic and diastolic blood pressures produced similar results. Goal of therapy (diastolic blood pressure no more than 90 mmHg or reduction of at least 10 mmHg) was achieved in 71% of nitrendipine-treated and 45% of placebo-treated patients (P less than 0.05). Nine of 80 patients randomized to therapy dropped out during treatment (nitrendipine: four adverse experiences and one moved from the area; placebo: two adverse experiences, and drug ineffective in two). Overall, the incidence of adverse experiences considered by the physician to be related to treatment was higher in the placebo group (32%) than in the nitrendipine group (23%). Only flushing had a higher incidence in the nitrendipine group; however, the overall incidence was low (9%).(ABSTRACT TRUNCATED AT 250 WORDS)
Mutants of <i>Escherichia coli</i> with an Altered Tyrosyl-Transfer Ribonucleic Acid Synthetase (1969)

We have isolated several mutants defective in the gene for tyrosyl-transfer ribonucleic acid (tRNA) synthetase (tyrS). One of these mutants is described in detail. It was isolated as a tyrosine auxotroph with defects both in the tyrosyl-tRNA synthetase and in the tyrosine biosynthetic enzyme, prephenate dehydrogenase. It also had derepressed levels of the tyrosine-specific 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase. The latter finding suggested that a wild-type tyrS gene was required for repression of the tyrosine biosynthetic enzymes. The following results demonstrated that this hypothesis was not correct. (i) When the defective tyrS gene was transferred to another strain, the tyrosine-specific DAHP synthetase in that strain was not derepressed, and (ii) two other mutants with defective tyrosyl-tRNA synthetases had repressed levels of the tyrosine biosynthetic enzymes. The tyrS gene was located near minute 32 on the Escherichia coli chromosome by interrupted mating experiments.
Atrial Fibrillation Begets Atrial Fibrillation (2008)

The intrinsic cardiac autonomic nervous system plays a crucial role in the acute stages of atrial electrical remodeling induced by rapid atrial pacing.
Expression and distribution characteristics of human ortholog of mammalian enabled (hMena) in glioma (2011)

Our data suggested that the expression of hMena is closely related to malignant grade of glioma. hMena can label the migrating cells, and indicate the migrating path of glioma cells from the tumor to adjacent tissue along with the vascular basement membranes and tracts of white matter.
An “Internet of Ears” for crowd-aware smart buildings based on sparse sensor networks (2017)

This paper introduces sparse low-power sensor networks using passive seismic sensors for crowd-aware smart buildings, resulting in an “Internet of Ears (IoE)” that can hierarchically detect human footsteps, estimate walk direction, and track person position. An energy-based thresholding footstep detector was developed using wavelet transform for pre-filtering the noise-prone ambient vibrations detected by the sensors. An efficient time delay estimate based on maximum power criterion is proposed for beamforming. Indoor occupant localization based on a least squares (LS) method and using improved time delay estimation is also briefly introduced. Experimental results in two different buildings show the effectiveness of the footstep detection and occupant localization methods, with detection accuracy of 98.3% and average localization error <;25 cm.
siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells (2009)

These findings suggest that antiapoptotic proteins play a significant role in the chemoresistance of chondrosarcoma cells independent of P-glycoprotein. Based on the results, a new siRNA-based therapeutic strategy targeting antiapoptotic genes can be designed to overcome the chemoresistance of chondrosarcomas which is often conferred by P-glycoprotein.
Robust Surface Reconstruction via Laplace-Beltrami Eigen-Projection and Boundary Deformation (2010)

In medical shape analysis, a critical problem is reconstructing a smooth surface of correct topology from a binary mask that typically has spurious features due to segmentation artifacts. The challenge is the robust removal of these outliers without affecting the accuracy of other parts of the boundary. In this paper, we propose a novel approach for this problem based on the Laplace-Beltrami (LB) eigen-projection and properly designed boundary deformations. Using the metric distortion during the LB eigen-projection, our method automatically detects the location of outliers and feeds this information to a well-composed and topology-preserving deformation. By iterating between these two steps of outlier detection and boundary deformation, we can robustly filter out the outliers without moving the smooth part of the boundary. The final surface is the eigen-projection of the filtered mask boundary that has the correct topology, desired accuracy and smoothness. In our experiments, we illustrate the robustness of our method on different input masks of the same structure, and compare with the popular SPHARM tool and the topology preserving level set method to show that our method can reconstruct accurate surface representations without introducing artificial oscillations. We also successfully validate our method on a large data set of more than 900 hippocampal masks and demonstrate that the reconstructed surfaces retain volume information accurately.
cGAS-STING pathway in oncogenesis and cancer therapeutics (2020)

The host innate immunity offers the first line of defense against infection. However, recent evidence shows that the host innate immunity is also critical in sensing the presence of cytoplasmic DNA derived from genomic instability events, such as DNA damage and defective cell cycle progression. This is achieved through the cyclic GMP-AMP synthase (cGAS)/Stimulator of interferon (IFN) genes (STING) pathway. Here we discuss recent insights into the regulation of this pathway in cancer immunosurveillance, and the downstream signaling cascades that coordinate immune cell recruitment to the tumor microenvironment to destroy transformed cells through cellular senescence or cell death programs. Its central role in immunosurveillance positions the cGAS-STING pathway as an attractive anti-cancer immunotherapeutic drug target for chemical agonists or vaccine adjuvants and suggests a key node to be targeted in a synthetic lethal approach. We also discuss adaptive mechanisms used by cancer cells to circumvent cGAS-STING signaling and present evidence linking chronic cGAS-STING activation to inflammation-induced carcinogenesis, cautioning against the use of activating the cGAS-STING pathway as an anti-tumor immunotherapy. A deeper mechanistic understanding of the cGAS-STING pathway will aid in the identification of potentially efficacious anti-cancer therapeutic targets.
Synthesis and Biological Evaluation of Heteroanalogues of Kotalanol and De-<i>O</i>-Sulfonated Kotalanol (2010)

The synthesis of nitrogen and selenium analogues of kotalanol and de-O-sulfonated kotalanol, naturally occurring sulfonium-ion glucosidase inhibitors isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against the N-terminal catalytic domain of human maltase glucoamylase (ntMGAM) are described.
Chemical Interactions with Bioherbicides to Improve Efficacy (1996)

Bioherbicides can be defined as plant pathogens, phytotoxins derived from pathogens or other microorganisms, augmentatively applied to control weeds. Although many pathogens with bioherbicidal potential have been discovered, most lack sufficient aggressiveness to overcome weed defenses to achieve adequate control. Plants use various physical and biochemical mechanisms to defend against pathogen infectivity, including callose deposition, hydroxyproline-rich glycoprotein accumulation, pathogenesis-related proteins (PR-proteins), phytoalexin production, lignin and phenolic formation, and free radical generation. Some herbicides, plant growth regulators, specific enzyme inhibitors, and other chemicals can alter these defenses. Various pathogens also produce chemical suppressors of plant defenses. Secondary plant metabolism is a major biochemical pathway related to several defense processes. Increased activity of a key enzyme of this pathway, phenylalanine ammonia-lyase (PAL), is often a response to pathogen attack, as demonstrated in two weeds and their associated bioherbicidal pathogens: Alternaria cassiae on sicklepod and A. crassa on jimsonweed. Weakening of physical and biochemical defenses, and lowering of resistance to pathogen attack, may result from reduced production of phenolics, lignin, and phytoalexins caused by herbicides and other chemicals that affect cuticular component biosynthesis and/or key aspects of secondary plant metabolism. Potent PAL inhibitors [aminooxyacetic acid, α-aminooxy-β-phenylpropionic acid, and (l-amino-2-phenylethyl)phosphonic acid] have some regulatory action on secondary plant metabolism and pathogenicity. Various herbicides and other chemicals dramatically affect extractable PAL activity levels and/or substantially alter PAL product production. Some non-pathogenic organisms can alter herbicide efficacy, and some herbicides influence disease development in plants. Research has shown some synergistic interactions of microbes and chemicals with relevance to weed control. Further research on pathogen interactions with agrochemicals (or other chemicals/regulators) could result in increased efficacy of pathogen-herbicide combinations, reduction of herbicide and pathogen levels required for weed control, and expanded pathogen host range.
A la villa «Le Bardo » (1914)

Klein Henri. A la villa «Le Bardo ». In: Les Feuillets d'El-Djezaïr, volume 7, 1914. Visites et excursions des années 1912 et 1913. Monographies. Écrits divers. pp. 30-31.
Face Recognition CAPTCHAs (2006)

Web-based services are becoming more and more ubiquitous and are replacing human-to-human interactions. Automated programs abuse the web services by pretending to be human. As a result, the need to authenticate that the other party on the web is a human and not a program, is on the rise. CAPTCHA is a test that can be used to reliably differentiate between human users and automated programs on the web. In this paper, we propose a new CAPTCHA scheme based on the problem of face recognition. This test takes advantage of the fact that recognizing human faces is considered to be a tough task for computers, but is relatively easy for humans. In the proposed test, human face photographs from a public database are distorted using two different image processing transformations. The user is asked to match distorted photographs of several different human subjects. The automatic generation and evaluation of tests is shown to be possible using the image processing open-source tool Gimp. The proposed CAPTCHAs have the desirable properties of being easy for humans while being difficult for programs to solve. Also the level of comfort in passing these tests is high, independently of the person’s familiarity with the English language, when compared to other English text based CAPTCHAs.
Handy MIMO (2005)

Emerging wireless communication systems require a combination of data rates, robustness and quality of service of unprecedented levels. The use of multiple antennas, at both the transmitter and the receiver, promises to enhance significantly the capacity offered by conventional systems. The reason MIMO (multiple input, multiple output) systems promise to be a key technology for the next revolution in wireless communications is that, in them, multipath propagation channels are not a burden; in fact, they are a benefit. The exploitation of diversity and parallel transmission of several data streams on different propagation paths at the same time and frequency allows for extremely large capacities compared to conventional wireless systems. However, if MIMO is to succeed, it will need to work seamlessly inside small mobile devices. Sophisticated signal processing - which is required for the multi-antenna systems - is currently one of the most active research areas in communications. Another key point of consideration when it comes to integrating MIMO systems into handhelds is RF technology. Multiple antennas squeezed into the housing of a handheld strongly interact and couple, which makes their design a real challenge from a physical point of view.
Myocardial uptake (rabbit) of six 99mTc-tagged pharmaceuticals and 85Sr after vasopressin-induced necrosis. (1977)

A new rapid method for producing myocardial necrosis in rabbits was developed, using percutaneous intramyocardial injection of vasopressin in peanut oil. The 15-min procedure resulted in a mortality rate of 15% and a success rate among surviving animals of 50%. When the lesions were 24 hr old, strontium-85 and a technetium-99m-tagged agent were injected intravenously simultaneously, and the animals were killed 1,6, and 24 hr later for tissue radioassay. Strontium-85 failed to accumulate appreciably in the lesions. Three bone-seeking technetium complexes (pyrophosphate, methylene diphosphonate, and imidodiphosphonate) produced lesion-to-normal myocardial ratios of 6,5, and 14, respectively, at 1 hr, and 20,30, and 33 at 6 hr. The ratios for 99mTc-glucoheptonate were only 2 at 1 hr and 4 at 6 hr, while the ratios of 99mTc-acetylcysteine and 99mTc-citrate were even lower.
Design of flexible plant layouts (2000)

Abstract In this paper, we present an approach for the design of plant layouts in stochastic environments. We consider systems where the, product mix and product demand are subject to variability and where duplicates of the same department type may exist in the same facility. In contrast to a job shop layout, we allow these duplicates to be placed in non-adjacent locations on the plant floor and for flow allocation between pairs of individual departments to be made as a function of the layout and the product demand realization. We present a scenario-based procedure that iteratively solves for layout and flow allocation. We show that having duplicates of the same departments, which can be strategically located in different areas of the plant floor, can significantly reduce material handling cost while effectively hedging against fluctuations in flow patterns and volumes. We show that the effect of duplication is of the diminishing kind, with most of the cost reduction occurring with relatively few duplicates. We also show that the quality of the obtained layouts can be quite insensitive to inaccuracies in estimating demand scenario probabilities. Additional informationNotes on contributorsSAIFALLAH BENJAAFAR E-mail: saif@tc.umn.edu MEHDI SHEIKHZADEH E-mail: Mehdi_Sheikhzadeh@i2.com
Cathepsin B and its role(s) in cancer progression (2003)

Experimental and clinical evidence has linked cathepsin B with tumour invasion and metastasis. Cathepsin B expression is increased in many human cancers at the mRNA, protein and activity levels. In addition, cathepsin B is frequently overexpressed in premalignant lesions, an observation that associates this protease with local invasive stages of cancer. Increased expression of cathepsin B in primary cancers, and especially in preneoplastic lesions, suggests that this enzyme might have pro-apoptotic features. Expression of cathepsin B is regulated at many different levels, from gene amplification, use of alternative promoters, increased transcription and alternative splicing, to increased stability and translatability of transcripts. During the transition to malignancy, a change in the localization of cathepsin B occurs, as demonstrated by the presence of cathepsin B-containing vesicles at the cell periphery and at the basal pole of polarized cells. Due to increased expression of cathepsin B and changes in intracellular trafficking, increased secretion of procathepsin B from tumours is observed. Active cathepsin B is also secreted from tumours, a mechanism likely to be facilitated by lysosomal exocytosis or extracellular processing by surface activators. Cathepsin B is localized to caveolae on the tumour surface, where binding to the annexin II heterotetramer occurs. Activation of cathepsin B on the cell surface leads to the regulation of downstream proteolytic cascade(s).
Applying Velocity Analysis to 3D Seismic-Based Mapping Error Quantification (2007)

Abstract This paper discusses velocity-analysis-based approach to mapping error quantification and its application in simulation modeling technique.
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy (2007)

Titin is a giant protein that is in charge of the assembly and passive mechanical properties of the sarcomere. Cardiac titin contains a unique N2B region, which has been proposed to modulate elasticity of the titin filament and to be important for hypertrophy signaling and the ischemic stress response through its binding proteins FHL2 and alphaB-crystallin, respectively. To study the role of the titin N2B region in systole and diastole of the heart, we generated a knockout (KO) mouse deleting only the N2B exon 49 and leaving the remainder of the titin gene intact. The resulting mice survived to adulthood and were fertile. Although KO hearts were small, they produced normal ejection volumes because of an increased ejection fraction. FHL2 protein levels were significantly reduced in the KO mice, a finding consistent with the reduced size of KO hearts. Ultrastructural analysis revealed an increased extension of the remaining spring elements of titin (tandem Ig segments and the PEVK region), which, together with the reduced sarcomere length and increased passive tension derived from skinned cardiomyocyte experiments, translates to diastolic dysfunction as documented by echocardiography. We conclude from our work that the titin N2B region is dispensable for cardiac development and systolic properties but is important to integrate trophic and elastic functions of the heart. The N2B-KO mouse is the first titin-based model of diastolic dysfunction and, considering the high prevalence of diastolic heart failure, it could provide future mechanistic insights into the disease process.
A counting and integrating pixel readout chip for amorphous selenium direct radiation detectors for medical imaging applications (2009)

A new pixel readout architecture is presented for amorphous selenium (a-Se) direct conversion radiation detectors. Photon-counting operation provides excellent sensitivity to low radiation doses but saturates the system at medium to high doses due to the poor charge transport properties of a-Se. Thus, we present an a-Se readout circuit design that is also capable of dynamically operating in integrating mode to enable the detection of high-dose radiation. This extends the resolvable dynamic range of the imaging system from very low gamma-ray count rates to very high flux x-ray radiations. The readout circuit is very promising for applications such as mammography tomosynthesis, and its benefits can also be extended to other radiation detectors. Finally, we present preliminary spectroscopy results with a-Se.
Traditionally-Used Antimalarials from the Meliaceae (2003)

A quantitative ethnobotanical approach to antimalarial drug discovery led to the identification of Lansium domesticum Corr. Ser. (Meliaceae) as an important antimalarial used by Kenyah Dyak healers in Indonesian Borneo. Triterpenoid lansiolides with antimalarial activity were isolated from the bark and shown to have activity in both in vitro bioassays with Plasmodium falciparum, and in mice infected with P. berghei. A survey of African and tropical American Meliaceae led to further development of the limonoid gedunin from the traditionally used medicinal plants, tropical cedar, Cedrela odorata L., and neem, Azadirachta indica A. Juss. Gedunin has significant in vitro activity but initially showed poor in vivo activity. In vivo activity was improved by (1) incorporation into an easy to absorb suspension, (2) preparation of a more stable compound, 7-methoxygedunin; and (3) synergism with dillapiol, a cytochrome P450 3A4 inhibitor. The results show the potential for both antimalarial drug and phytomedicine development from traditionally used plants.