gebhart/patrepeval huggingface dataset:
AR splice variant 7 (AR-V7) and response to taxanes in men with metastatic castration-resistant prostate cancer (mCRPC). (2015)

138 Background: AR-V7 is a truncated form of AR that lacks the ligand-binding domain but remains constitutively active. We previously showed that detection of AR-V7 from circulating tumor cells (CTCs) in men with mCRPC was associated with primary resistance to enzalutamide and abiraterone. Here, we hypothesized that AR-V7[+] patients would retain sensitivity to taxane chemotherapy. Methods: We used a qRT-PCR assay to interrogate CTCs for AR-V7 mRNA in prospectively enrolled patients with mCRPC starting docetaxel or cabazitaxel. We sought associations between AR-V7 status and PSA response rates (the primary endpoint), PSA progression-free survival (PSA-PFS), and clinical/radiographic progression-free survival (PFS). Multivariable regressions were performed to determine the independent effect of AR-V7 status on clinical outcomes. 36 taxane-treated men were required to produce a 2-sided 95% CI for the difference in PSA response rates (between AR-V7[+] and AR-V7[–] men) with an upper bound of 60%, assuming that 30% of men would be AR-V7[+]. Results: 37 taxane-treated patients were enrolled, and 17 (45.9%) had detectable AR-V7 in CTCs. PSA responses were achieved in both AR-V7[+] and AR-V7[–] men (41% vs 65%, P=0.19). Median PSA-PFS was comparable in AR-V7[+] and AR-V7[–] men (4.5 vs 6.2 mo, HR 1.72, P=0.32). Likewise, median PFS was comparable in AR-V7[+] and AR-V7[–] men (5.1 vs 6.9 mo, HR 2.65, P=0.11). After incorporating data from our prior study in 62 abi/enza-treated patients, it was observed that clinical outcomes in AR-V7[+] men were superior with taxanes than with abi/enza, while outcomes did not differ by treatment type in AR-V7[–] men. For example, in AR-V7[+] men, PSA responses were higher in taxane-treated versus abi/enza-treated men (41% vs 0%, P<0.001), and median PSA-PFS and PFS were longer in taxane-treated men (HR for PSA-PFS = 0.19, P=0.001; HR for PFS = 0.21, P=0.003). Conclusions: Detection of AR-V7 in CTCs from men with mCRPC is not associated with primary resistance to taxane chemotherapy, and such patients may retain sensitivity to taxanes. Further, in AR-V7[+] men, taxanes appear to be more efficacious than abi/enza. AR-V7 may represent a treatment-selection marker in mCRPC.
Decomposition of Soybean Spherosomes by Soybean Phospholipase D (1981)

Journal Article Decomposition of Soybean Spherosomes by Soybean Phospholipase D Get access Yoriko Nakayama, Yoriko Nakayama Research Institute for Food Science, Kyoto University, Uji, Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Makoto Kito Makoto Kito Research Institute for Food Science, Kyoto University, Uji, Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 45, Issue 9, 1 September 1981, Pages 2155–2156, https://doi.org/10.1080/00021369.1981.10864853 Published: 01 September 1981 Article history Received: 07 April 1981 Published: 01 September 1981
A Review of the Structure and Physical Properties of Liquid Crystals (1973)

This work is a review of the nature and some of the properties of liquid crystals. In the 80 pages or so of text, it is quite clear that it could not be exhaustive or complete.
Vortex via process: analysis and mask fabrication for contact CDs <80 nm (2003)

In an optical vortex, the wavefront spirals like a corkscrew, rather than forming planes or spheres. Since any nonzero optical amplitude must have a well-defined phase, the axis of a vortex is always dark. Printed in negative resist at 248nm and NA=0.63, 250nm pitch vortex arrays would produce contact holes with 80nm<CD<160nm(0.2<<i>k</i><sub>1</sub><0.4), depending on exposure dose. Arrays of vortices with <i>k</i><sub>pitch</sub>>0.6 can be patterned using a chromeless phase-edge mask composed of rectangles with nominal phases of 0°, 90°, 180° and 270°. Analytic and numerical calculations have been performed to characterize the aerial images projected from such vortex masks using the Kirchhoff-approximation and rigorous EMF methods. Combined with resist simulations, these analyses predict process windows with ≈10%<i>E</i><sub>lat</sub> and >200nm DOF for 80nm CDs on pitches greater than or equal to 250nm at σ greater than or equal to 0.15. Smaller CDs and pitches are possible with shorter wavelength and larger NA while larger pitches give rise to larger CDs. At pitch >0.8μm, the vortices begin to print independently for σ greater than or equal to 0.3. Such “independent” vortices have a quasi-isofocal dose that gives rise to 100nm contacts with <i>E</i><sub>lat</sub>>9% and DOF>500nm at σ=0.3. The extra darkness of the nominal 270° phase step can be accommodated by fine-tuning the etch depth. A reticle fabrication process that achieves the required alignment and vertical wall profiles has been exercised and test masks analyzed. In an actual chip design, unwanted vortices and phase step images would be erased from the resist pattern by exposing the wafer with a second, more conventional trim mask. Vortex via placement is consistent with the coarse-gridded grating design paradigms which would - if widely exercised - lower the cost of the required reticles. Compared to other ways of producing deep sub-wavelength contacts, the vortex via process requires fewer masks and reduces the overlay and process control challenges. A high resolution negative-working resist process is essential, however.
Fast and easy language understanding for dialog systems with Microsoft Language Understanding Intelligent Service (LUIS) (2015)

With Language Understanding Intelligent Service (LUIS), developers without machine learning expertise can quickly build and use language understanding models specific to their task. LUIS is entirely cloud-based: developers log into a website, enter a few example utterances and their labels, and then deploy a model to an HTTP endpoint. Utterances sent to the endpoint are logged and can be efficiently labeled using active learning. Visualizations help identify issues, which can be resolved by either adding more labels or by giving hints to the machine learner in the form of features. Altogether, a developer can create and deploy an initial language understanding model in minutes, and easily maintain it as usage of their application grows.
Controlled and Cardiac-Restricted Overexpression of the Arginine Vasopressin V1A Receptor Causes Reversible Left Ventricular Dysfunction Through Gα<sub>q</sub>-Mediated Cell Signaling (2011)

Our results demonstrate a role for V1A-mediated signaling in the development of heart failure and support a role for V1A blockade in the treatment of patients with elevated levels of vasopressin.
Texture Segmentation of Road Environment Scene Using SfM Module and HLAC Features (2009)

This paper presents a new image segmentation method for the recognition of texture-based objects in a road environment scene. Using the proposed method, we can classify texture-based objects three dimensionally using the SfM (Structure from Motion) module and the HLAC (Higher-order Local Autocorrelation) features. By estimating the vehicle's ego-motion, the SfM module can reconstruct the three dimensional structure of the road scene. Texture features of input images are extracted from HLAC functions according to their depth, as obtained using the SfM module. The proposed method can effectively recognize texture-based objects of a road scene by considering their three-dimensional structure in a perspective 2D image. Experimental results show that the proposed method can not only effectively classify the texture patterns of structures in a 2D road scene, but also represent classified texture patterns as three-dimensional structures. The proposed system can revolutionize a three-dimensional scene understanding system for vehicle environment perception.
Improved plasmids for gene targeting at the his-3 locus of Neurospora crassa by electroporation (1997)

Improved plasmids for gene targeting at the his-3 locus of Neurospora crassa by Improved plasmids for gene targeting at the his-3 locus of Neurospora crassa by electroporation electroporation
Digital Electronic Controls for Detroit Diesel Allison Heavy Hauling Transmissions (1986)

<div class="htmlview paragraph">Detroit Diesel Allison introduced it's first electronic controlled transmission, the DP 8000 series transmission, in 1971 with the discrete lope shift pattern generator (SPG). In 1983, a new state-of-the-art digital electronic control option called ATEC (Allison Transmission Electronic Control) was offered on the V 730 series transit coach transmission. ATEC was introduced to the HT 700 series transmission including the CLBT 755 series off-highway transmissions in 1984.</div> <div class="htmlview paragraph">In January 1986, the ATEC system replaced the current SPG electronics across the board on 5, 6, 8, and 9000 series off-highway transmissions. ATEC provides greater capability and increased reliability at a reduced cost over the SPG electronics. The ATEC system is currently in a field test program that will continue through the first year of production to monitor its reliability improvement over the SPG system. Controlled testing to SAE standards have quantified fuel economy and productivity gains with ATEC.</div>
A Modular Approach to Delivering an Introductory MIS Course (2010)

Today’s students find the traditional lecture-based teaching format less desirable and seem to prefer a more hands-on learning experience. Consequently, it has become necessary to redesign this MIS course. This paper describes a new modular approach to delivering the introductory course. The primary focus is to provide students with multiple resources and handson projects, along with detailed learning objectives, in lieu of traditional PowerPoint lectures and textbook assignments. A pilot study was initiated to assess student perceptions of the learning experience with regard to the effectiveness and overall satisfaction with the new approach. A learning styles survey, along with a follow-up feedback survey, was distributed to 29 traditional and non-traditional students. Considering the small sample size, initial results were encouraging.
Secure ADS-B: Towards Airborne Communications Security in the Federal Aviation Administration's Next Generation Air Transportation System (2014)

Abstract : The U.S. Congress has mandated that all aircraft operating within the National Airspace System, military or civilian, be equipped with ADS-B transponders by the year 2020. The ADS-B aircraft tracking system, part of the Federal Aviation Administration's NextGen overhaul of the Air Transportation System, replaces Radar-based surveillance with a more accurate satellite-based surveillance system. However, the unencrypted nature of ADS-B communication poses an operational security risk to military and law enforcement aircraft conducting sensitive missions. The non-standard format of its message and the legacy communication channels used by its transponders make the ADS-B system unsuitable for traditional encryption mechanisms. FPE, a recent development in cryptography, provides the ability to encrypt arbitrarily formatted data without padding or truncation. Indeed, three new algorithms recommended by the NIST, may be suitable for encryption of ADS-B messages. This research assesses the security and hardware performance characteristics of the FF1, FF2, and FF3 algorithms, in terms of entropy of ciphertext, operational latency and resource utilization when implemented on a Field-Programmable Gate Array. While all of the algorithms inherit the security characteristics of the underlying AES block cipher, they exhibit differences in their performance profiles. Findings demonstrate that a Bump-in-the-Wire FPE cryptographic engine is a suitable solution for retrofitting encryption to ADS-B communication.
A plastic waveguide receiver in 40nm CMOS with on-chip bondwire antenna (2013)

This paper presents the design and measurements of a 40 nm CMOS BPSK and multilevel ASK receiver for wired connections through a plastic waveguide, operating at 87 GHz. In a measurement setup containing the receiver chip with bondwire dipole antenna and a long piece of polypropylene waveguide with a rectangular cross-section of 2.2 mm by 0.9 mm, a maximum datarate of 9 Gbit/s over a distance of 60 cm and 2.5 Gbit/s over a distance of 9 m is measured, both with a bit error rate of less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> and a PRBS length of 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> - 1. The chip consumes 50 mW of DC power from a 0.9 V supply. The total chip area is 2.1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , of which 52 % is occupied by the antenna and reflector.
Policy-Based Spectrum Access Control and Management for Multi-Band Cognitive Radio Systems for Public Safety Communications (2007)

This paper addresses methods for adequately controlling cognitive radio (CR) and software defined radio (SDR) devices that are capable of operating across multiple frequency bands, jurisdictions and networks, including those used by Federal, State and local first responders in both day-to-day and emergency operations. The Public Safety community is rightfully wary that premature deployment of multi-band CR devices could have unintended consequences and unanticipated impacts, such as security threats and increased interference risks. Key players have recommended caution in the introduction of new technologies for Public Safety applications, suggesting to regulators that initial deployments of cognitive radios should take place under controlled conditions in geography and spectrum where critical usage is low. We describe how an end-to-end, multi-band CR system should be developed, customized and safely tested for use by Public Safety organizations. Our primary focus is on a spectrum management subsystem that controls the Public Safety CR devices via the composition and dissemination of machine-readable spectrum access policies” This Cognitive Radio Access and Management (CRAM) subsystem would provide Public Safety spectrum and network managers with transparent, flexible and adaptable tools to remotely control a large number of heterogeneous CR devices in a cost effective, reliable manner, while protecting legacy networks from harmful interference. Specifically, the CRAM subsystem would (1) facilitate the development and dissemination of a wide range of spectrum access and priority rules that are based on regulatory and user requirements; (2) provide for logging and other safeguards to monitor usage and quickly resolve interference events; (3) incorporate trusted security measures to avoid unauthorized access; and (4) include other features necessary to satisfy complex Public Safety requirements.
Antileukemic Activity of <i>Bidens pilosa</i> L. <i>var. minor</i> (Blume) Sherff and <i>Houttuynia cordata</i> Thunb. (2001)

To evaluate the anti-leukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb., cytotoxicity tests with an XTT-based colorimetric assay were used. Five leukemic cell lines, namely L1210, U937, K562, Raji and P3HR1, were cultured with hot water extracts of B. pilosa var. minor or H. cordata. Hot water extracts of B. pilosa var. minor inhibited these five leukemic cells with IC50s between 145 microg/ml and 586 microg/ml. The effect was greatest on four cell lines, namely L1210, P3MR1, Raji and K562, with IC50s below 200 microg/ml and a selective index of more than 5. Hot water extract of H. cordata inhibited these five leukemic cells with IC50s between 478 microg/ml and 662 microg/ml. The selective index was between 1.5 and 2.1. B. pilosa var. minor was more effective than H. cordata in inhibiting most of the leukemic cells in our study. We suggest that B. pilosa L. var. minor (Blume) Sherff may prove to be a useful medicinal plant for treating leukemia.
ESTIMATION OF PURE-COMPONENT PROPERTIES FROM GROUP-CONTRIBUTIONS (1987)

Abstract Simple group-contribution methods are proposed to estimate eleven important physical properties of pure materials. A common set of structural groups was employed. High accuracy is not claimed, but the proposed methods are often as accurate as or more accurate than techniques in common use today.
Capacitor-free level-sensitive active pull-down ECL circuit with self-adjusting driving capability (1996)

This paper introduces a new self-adjusting active pull-down scheme for ECL circuit. The circuit offers self-terminating dynamic pull-down action by sensing the output level rather than using traditional load-dependent capacitive coupling. No capacitor or large resistor is required, and therefore it adds no process complexity and no area penalty. Implemented in an ECL gate array in a 1.2 /spl mu/m double-poly self aligned bipolar technology, the circuit offers 300-ps delay at a power consumption of 1 mW/gate under FO=1 and C/sub L/=0.55 pF loading condition. This is a 4.4 times speed improvement over the conventional ECL circuit. Furthermore, the circuit consumes only 0.25 mW for a gate speed of 700 ps/gate, which is a 1/7.8 power reduction compared with the conventional ECL circuit. The circuit requires a regulated reference voltage, which is also studied.
Sediment Characteristics as a Function of Variable Hydrodynamics in a Tidal Flat of the Yellow River Delta, China (2013)

The role of hydrodynamics in the secondary reworking of sediment in a tidal flat of the Yellow River delta was studied. Field hydrodynamic conditions were measured in the study area, and subsurface and surface samples at selected points were collected. Laboratory analyses were performed to measure variations in the grain sizes, mineral constituents, and microstructures of the sediment. Moreover, fractal dimension calculations were introduced to obtain additional quantitative sedimentological data. The results of the studies indicate clear responses of the seabed sediment to variations in the hydrodynamic conditions both in the vertical profile and in a seaward transect and indicate that hydrodynamic changes can play a significant role in sculpting the topographic features of tidal flats.
Synthesis of 3-aryl-1-adamantanemethylamines (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 3-aryl-1-adamantanemethylaminesIndra Handa and Ludwig BauerCite this: J. Chem. Eng. Data 1984, 29, 2, 223–225Publication Date (Print):April 1, 1984Publication History Published online1 May 2002Published inissue 1 April 1984https://pubs.acs.org/doi/10.1021/je00036a037https://doi.org/10.1021/je00036a037research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oxidation of Polycyclic Aromatic Hydrocarbons under Sulfate-Reducing Conditions (1996)

[(sup14)C]naphthalene and phenanthrene were oxidized to (sup14)CO(inf2) without a detectable lag under strict anaerobic conditions in sediments from San Diego Bay, San Diego, Calif., that were heavily contaminated with polycyclic aromatic hydrocarbons (PAHs) but not in less contaminated sediments. Sulfate reduction was necessary for PAH oxidation. These results suggest that the self-purification capacity of PAH-contaminated sulfate-reducing environments may be greater than previously recognized.
The Cartographic State (2013)

Why is today&apos;s world map filled with uniform states separated by linear boundaries? The answer to this question is central to our understanding of international politics, but the question is at the same time much more complex - and more revealing - than we might first think. This book examines the important but overlooked role played by cartography itself in the development of modern states. Drawing upon evidence from the history of cartography, peace treaties and political practices, the book reveals that early modern mapping dramatically altered key ideas and practices among both rulers and subjects, leading to the implementation of linear boundaries between states and centralized territorial rule within them. In his analysis of early modern innovations in the creation, distribution and use of maps, Branch explains how the relationship between mapping and the development of modern territories shapes our understanding of international politics today.
Insulin-like growth factor-II as a prognostic factor in pulmonary adenocarcinoma (1996)

We stained resected specimens from 117 patients with pulmonary adenocarcinoma for insulin-like growth factor-II (IGF-II) by the avidin-biotin-peroxidase (ABC) method and evaluated the usefulness of IGF-II as a prognostic factor. The patients were classified into the IGF-II (+) groups showing staining of 1% or more cancer cells (60 patients) and the IGF-II (-) groups showing staining of <1% (57 patients). The 5-year survival rate was 22% in the IGF-II (+) group and 54% in the IGF-II (-) group (P<0.01). Our results suggest the usefulness of IGF-II stainability as a prognostic factor of pulmonary adenocarcinoma.
Multidrug resistance-associated protein and mutant p53 protein expression in non-small cell lung cancer. (1998)

Multidrug resistance-associated protein (MRP) is one of the major factors for non-P-glycoprotein (PGp)-mediated multidrug resistance. We reported previously that overexpression of the MRP gene was related to the prognosis of non-small cell lung cancer (NSCLC). It is unclear how MRP expression is regulated in NSCLC. In this study, we examined MRP and mutant p53 expression in 107 NSCLCs by immunohistochemical procedures. Forty-seven (43.9%) of these 107 NSCLCs were positive for MRP in the cytoplasm. Mutant p53-positive NSCLC showed a significant correlation with MRP overexpression (P=.011). Coexpression of MRP and p53 in the same cells of NSCLC was confirmed by double-staining procedures. Twenty-six patients with MRP-positive tumors who underwent postoperative chemotherapy with MRP-related anticancer drugs (vindesine and etoposide) had significantly poorer prognoses than did those with MRP-negative tumors (P=.017). This correlation between MRP expression and prognosis was also seen in Stage III patients (P=.022) and in patients with squamous cell carcinoma (P=.062). NSCLC patients with coexpression of MRP and p53 showed poorer prognoses than did those without MRP and p53 (P=.014). These results suggested that MRP overexpression affected by mutant p53 had a significant effect on prognosis through atypical non-PGp-mediated multidrug resistance in NSCLC.