THE DYNAMICS OF LEUKOPENIA AND LEUKOCYTOSIS† (1960)

Article1 February 1960THE DYNAMICS OF LEUKOPENIA AND LEUKOCYTOSIS†CHARLES G. CRADDOCK JR., M.D., F.A.C.P., SEYMOUR PERRY, M.D., F.A.C.P., JOHN S. LAWRENCE, M.D., F.A.C.P.CHARLES G. CRADDOCK JR., M.D., F.A.C.P., SEYMOUR PERRY, M.D., F.A.C.P., JOHN S. LAWRENCE, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-2-281 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany features of the physiology of leukocytes are controversial. The origin of certain cells—for example, the monocyte and the plasma cell—is disputed. The functions of many of the cell species (e.g., the variously sized lymphocytes, the eosinophil, the basophil) are still conjectural, despite recent advances in cytochemistry. The lymphocyte has been implicated in such fundamental processes as immune globulin synthesis, antibody transport,1 and the transmission of genetic material or information to proliferating tissues.2 They have also been described as "pluripotential" cells, capable of differentiation into other hemic cells.3In contrast to these less well defined and esoteric functions of other...Bibliography1. KelsallCrabb MAED: Lymphocytes and plasmacytes in nucleoprotein metabolism, Ann. New York Acad. Sc. 72: 293-338, 1958. CrossrefMedlineGoogle Scholar2. Hamilton LD: Metabolic stability of PNA and DNA in human leukemic leukocytes; the function of lymphocytes, in The leukemias, Henry Ford Hospital International Symposium, 1957, Academic Press, Inc., New York, pp. 381-401. CrossrefGoogle Scholar3. BondFliednerCronkiteRubiniBrecherSchork VPTMEPJRGPK: Proliferative potentials of bone marrow and blood cells studied by in vitro uptake of H3 thymidine, Acta haemat. 21: 1-15, 1959. 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M. Sc. 217: 379-382, 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California*Received for publication May 16, 1959.Presented in part at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 22, 1959.From the Department of Medicine, School of Medicine, University of California at Los Angeles, and the Hematology Research Laboratory, Wadsworth Hospital, Veterans Administration Medical Center, Los Angeles, California.This work was supported in part by the U. S. Public Health Service, under contract #H-1069, and by a grant from Parke-Davis & Co.Requests for reprints should be addressed to C. G. Craddock, Jr., M.D., Department of Medicine, University of California Medical Center, Los Angeles 24, California. 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