gebhart/patrepeval huggingface dataset:
[Multicenter study comparing the efficacy and tolerance of topical ciprofloxacin (0.3%) versus topical gentamicin (0.3%) in the treatment of simple, non-cholesteatomaous chronic otitis media in the suppurative phase]. (1995)

A multicentre double-blind randomized study was carried out to compare topical ciprofloxacin and topical gentamicin in the treatment of simple non-cholesteatomatous purulent chronic otitis media. Three hundred and eight patients were included in the study, 159 treated with ciprofloxacin and 149 treated with gentamicin. The percentage of clinical success (elimination of otorrhoea) was 95% with ciprofloxacin and 94% with gentamicin (ns). Likewise, the percentage of bacteriological erradication was 96% with ciprofloxacin and 93% with gentamicin. Both drugs were well tolerated, without changes in the audiometric values. In these patients, topical ciprofloxacin shows the same efficacy as topical gentamicin without any potential ototoxic effect.
One-Pot Synthesis of Squaraine Fluoroionophores (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTOne-Pot Synthesis of Squaraine FluoroionophoresUmut Oguz and Engin U. AkkayaView Author Information Department of Chemistry, Middle East Technical University, TR-06531 Ankara, Turkey Cite this: J. Org. Chem. 1998, 63, 17, 6059–6060Publication Date (Web):August 1, 1998Publication History Received18 March 1998Published online1 August 1998Published inissue 1 August 1998https://pubs.acs.org/doi/10.1021/jo9805145https://doi.org/10.1021/jo9805145brief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views732Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Absorption,Chemical synthesis,Fluorescence,Reaction products,Squaraine Get e-Alerts
Wind farms with increased transient stability margin provided by a STATCOM (2006)

This paper analyzes the extent to which the transient stability margin of wind farms using squirrel cage generators can be increased by the use of a STATCOM. A simplified analytical approach is used first to quantify the effect of the STATCOM on the transient stability margin. An experimental validation of the calculated transient margin is then presented by measurements done in a laboratory prototype of 7.5 kW emulating a wind turbine or wind farms. Measurement results confirm that the STATCOM provides a clear transient stability margin increase and with adequate rating it becomes possible to ride through severe faults
Evaluation of Nitazoxanide for the Treatment of Disseminated Cystic Echinococcosis: Report of Five Cases and Literature Review (2011)

We aimed to evaluate the effectiveness of nitazoxanide in disseminated cystic echinococcosis (DCE) that failed to respond to surgical and antiparasitic therapy. We report on seven patients (five of them with bony involvement): two cases from the literature and five patients who were included in a compassionate trial of nitazoxanide therapy in our hospital. Median follow-up time until nitazoxanide therapy was 12 years and all patients had received prior medical treatment and extensive surgery. Nitazoxanide (500 mg/12 h) in combination with albendazole, with/without praziquantel, was administered for 3-24 months. Three patients improved: one with muscle involvement (clinico-radiological response), one with lung involvement (radiological response), and another with soft tissue and bony involvement (clinico-radiological response of soft tissue cysts). There was one discontinuation after 15 days of starting therapy. Nitazoxanide combination therapy could have a role in the treatment of DCE when there is no bony involvement. Long-term safety profile seems to be favorable.
Soliton-repulsion logic gate (1996)

We present numerical simulations of a logic gate based on repulsive interaction in a dual-core fiber and call it a soliton-repulsion logic gate (SRLG). The operation of the SRLG is compared with that of the conventional soliton-dragging logic gate based on cross-phase modulation. The length of the SRLG can be reduced by a factor of 3 over that of the conventional logic gate. By optimizing parameters, terahertz operation can be obtained.
Relationship between compressive yield strength and filler fractions of PMMA composites (1982)

AbstractEffects, of volume fraction filler and silane treatment on compressive yield strength of experimental PMMA composites were investigated and explained by use of the Coulomb yield criteria. The results showed that an increase in volume fraction filler will not automatically increase compressive strength, and that the silane treatment is of greatest importance to optimize the compressive strength of a composite.Key Words: Silane treatmentinternal frictional theoryfiller formstress concentration
In Vitro Fungicidal Activities of Voriconazole, Itraconazole, and Amphotericin B against Opportunistic Moniliaceous and Dematiaceous Fungi (2001)

The NCCLS proposed standard M38-P describes standard parameters for testing the fungistatic antifungal activities (MICs) of established agents against filamentous fungi (molds); however, standard conditions are not available for testing their fungicidal activities (minimum fungicidal or lethal concentrations [MFCs]). This study evaluated the in vitro fungistatic and fungicidal activities of voriconazole, itraconazole, and amphotericin B against 260 common and emerging molds (174 Aspergillus sp. isolates [five species], 23 Fusarium sp. isolates [three species], 6 Paecilomyces lilacinus isolates, 6 Rhizopus arrhizus isolates, 23 Scedosporium sp. isolates, 23 dematiaceous fungi, and 5 Trichoderma longibrachiatum isolates). MICs were determined by following the NCCLS M38-P broth microdilution method. MFCs were the lowest drug dilutions that resulted in fewer than three colonies. Voriconazole showed similar or better fungicidal activity (MFC at which 90% of isolates tested are killed [MFC(90)], 1 to 2 microg/ml) than the reference agents for Aspergillus spp. with the exception of Aspergillus terreus (MFC(90) of voriconazole and amphotericin B, >8 microg/ml). The voriconazole geometric mean (G mean) MFC for Scedosporium apiospermum was lower (2.52 microg/ml) than those of the other two agents (5.75 to 7.5 microg/ml). In contrast, amphotericin B and itraconazole G mean MFCs for R. arrhizus were 2.1 to 2.2 microg/ml, but that for voriconazole was >8 microg/ml. Little or no fungicidal activity was shown for Fusarium spp. (2 to >8 microg/ml) and Scedosporium prolificans (>8 microg/ml) by the three agents, but voriconazole had some activity against P. lilacinus and T. longibrachiatum (G mean MFCs, 1.8 and 4 microg/ml, respectively). The fungicidal activity of the three agents was similar (G mean MFC, 1.83 to 2.36 microg/ml) for the dematiaceous fungi with the exception of the azole MFCs (>8 microg/ml) for some Bipolaris spicifera and Dactylaria constricta var. gallopava. These data extend and corroborate the available fungicidal results for the three agents. The role of the MFC as a predictor of clinical outcome needs to be established in clinical trials by following standardized testing conditions for determination of these in vitro values.
An SQL interface to X.500 (1995)

The X.500 standard specifies a distributed directory service designed to store information about people and objects associated with computer networks. Its API is geared toward retrieving information based on this application domain. Recently, a number of projects have used the directory in non-traditional ways. Such applications, however, are constrained by the X.500 information model and the limited functionality of its API. We describe a prototype system that allows users to view the information in a directory as relations, and to query the view using SQL. An analysis of the performance of the system is presented and possible optimizations are discussed.
Fabrication of functional 3D hepatic tissues with polarized hepatocytes by stacking endothelial cell sheets<i>in vitro</i> (2015)

Cell sheet stratification technology has been used for reconstituting highly functional three-dimensional (3D) hepatic tissues in vitro. Triple-layered hepatic tissues with a hepatocyte-specific polarity were fabricated by sandwiching a hepatocyte sheet (Hep sheet) between two endothelial cell (EC) sheets. The morphological and functional characteristics of the triple-layered hepatic construct (EC-Hep-EC) were evaluated and compared with those of a double-layered hepatic construct with a single EC sheet (Hep-EC) and a Hep sheet only. Transmission electron microscope (TEM) observations revealed that the extracellular matrix was observed to be deposited in the space between the ECs and hepatocytes on both the upper and lower sides of the hepatocytes in the EC-Hep-EC construct. Immunohistochemistry with basolateral (CD147) and apical [multidrug resistance-associated protein (MRP2)] membrane polarity markers clearly showed the recovery of in vivo-like hepatocyte polarization in the EC-Hep-EC group. In addition, hepatocyte-specific functions, including albumin secretion, ammonia removal and the induction of cytochrome P450, were also highly preserved. The presented technology for stratifying multiple cell sheets was simple in operation and successfully reproduced both the heterotypic/homotypic cell-cell and cell-matrix interactions with the inherent hepatocyte configurations, thus closely mimicking the in vivo environment. The triple-layered 3D hepatic constructs could therefore be valuable as a new experiment tool for drug-screening tests, an implantable tissue model for cell-based therapies and an efficient culture platform for bioartificial liver devices. Copyright © 2015 John Wiley & Sons, Ltd.
Two-Photon X-Variation Mapping Based on a Diode-Pumped Femtosecond Laser (2010)

Abstract By inducing two-photon absorption within the device layer of a proprietary silicon test chip, the first nonlinear variant of X-variation mapping is reported by demonstrating frequency mapping of a ring oscillator circuit at 1.55µm.
Garveatin A, an antimicrobial 1(4H)-anthracenone derivative from the hydroid Garveia annulata (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleGarveatin A, an antimicrobial 1(4H)-anthracenone derivative from the hydroid Garveia annulataEoin Fahy, Raymond J. Andersen, Cun Heng He, and Jon ClardyCite this: J. Org. Chem. 1985, 50, 7, 1149–1150Publication Date (Print):April 1, 1985Publication History Published online1 May 2002Published inissue 1 April 1985https://pubs.acs.org/doi/10.1021/jo00207a057https://doi.org/10.1021/jo00207a057research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Continuous and discrete Fourier transforms of steplike waveforms (1982)

A steplike waveform which has attained its final value is converted into a duration-limited one which preserves the spectrum of the original waveform and is suitable for discrete Fourier transform (DFT) computations. The method, which is based upon the response of a time-invariant linear system excited by a rectangular pulse of suitable duration, is first applied to continuous waveforms and then to discrete (sampled) waveforms. The difference (errors) between the spectra of a continuous waveform and a discrete representation of it are reviewed.
Enhancing the Deployment and Security of SIPRNET and JWICS Networks using Intrinsic Fiber Monitoring (2007)

With the increased requirements for SIPRNET and JWICS access, secure network connectivity has become increasingly pervasive throughout the Department of Defense. The increased deployment of secure networks has resulted in an evolution of secure network architectures and the Information Assurance methods and tools used to protect them. Specifically, new technological advances in the ability to monitor and protect fiber optic cables and connections possess huge potential for cost savings and enhanced protection of critical networks and C4ISR facilities. With the accelerated development and deployment of C4ISR applications on the Global Information Grid, warfighters are developing a strategic dependence upon the availability and integrity of secure networks. While encryption has been used for decades to protect the confidentiality and non-repudiation of national security information (NSI), encryption alone provides no coverage or protection against threats to network availability and integrity. Through recent developments in intrinsic fiber monitoring technology, critical connections can now be proactively monitored to detect any threats or physical attacks on the network WITHOUT degrading network performance or restricting network bandwidth. Using the principles of the Defense in Depth strategy, intrinsic fiber monitoring provides a very agile and scalable protection methodology that can be used by itself or in combination with cryptographic equipment to provide the required protection of classified networks and the ability to withstand the ever-increasing threats to the networks.
<i>ent</i>-Kaurane Diterpenoids from <i>Isodon</i> <i>albopilosus</i> (2005)

Nine new diterpenoids, albopilosins B-J (1-9), together with six known analogues, albopilosin A (10), macrocalyxin C (11), rabdokunmin C (12), excisanin (13), amethystonoic acid (14), and coetsanoic acid (15), were isolated from the aerial parts of Isodon albopilosus. The structures of 1-9 were established using spectroscopic methods including extensive 1D and 2D NMR analysis. The diterpenoids isolated were evaluated for their inhibitory activities against HepG2 (hepatoma) cells. Compounds 7 and 13 were the most active, with both having IC(50) values of <15 microM.
Incremental parsing in a continuous dynamical system: sentence processing in Gradient Symbolic Computation (2017)

Abstract Any incremental parser must solve two computational problems: (1) maintaining all interpretations consistent with the words that have been processed so far and (2) excluding all globally-incoherent interpretations. While these problems are well understood, it is not clear how the dynamic, continuous mechanisms that underlie human language processing solve them. We introduce a Gradient Symbolic Computation (GSC) parser, a continuous-state, continuous-time stochastic dynamical-system model of symbolic processing, which builds up a discrete symbolic structure gradually by dynamically strengthening a discreteness constraint. Online, interactive tutorials with open-source software are presented in a companion website. Our results reveal that the GSC parser can solve the two computational problems by moving to a non-discrete blend state that evolves exclusively to discrete states representing contextually-appropriate globally-coherent interpretations. In a simulation study using a simple formal grammar, we show that successful parsing requires appropriate control of the discreteness constraint strength (a quantization policy ). With inappropriate quantization policies, the GSC parser makes mistakes that mirror those made in natural language comprehension (garden-path or local-coherence errors). These findings suggest that the GSC model offers a neurally plausible solution to these two core problems.
Femtosecond laser writing of waveguide structures in sodium calcium silicate glasses (2005)

Waveguides were written in soda lime silicate glasses with a composition of xNa<sub>2</sub>O xCaO (1-2x)SiO<sub>2</sub>, where x = 15 and 20, using an amplified femtosecond laser. The waveguides formed around, not inside the exposed regions. This is similar to the waveguide behavior our group first observed in a phosphate glass, Schott IOG-1, and is distinctly different from fused silica in which the waveguides are inside the exposed regions. This data supports the rapid quenching theory, i.e. that the exposed regions cool rapidly, locking in a glass structure with a high fictive temperature, with the dependence of the refractive index on the glass cooling rate determining the qualitative behavior of the waveguides.
Modeling and Implementation of a Generic BOM Management System Using Object-Oriented Modeling Technique (1999)

BOM(Bill of Material) is a description of parts, assemblies and raw materials that comprise a product structure. In manufacturing companies that produce various products with short life cycles, it is very important to manage to BOM of products with various options and versions efficiently. This paper describes an effective modeling and implementing technique of Generic BOM Management System(GBMS) for management of number of variant products. In this paper, OMT(Object Modeling Technique) was used to model a generic BOM and Object-Relational Database Management System(ORDBMS) was used to implement the GBMS database. In order to prove the effectiveness of proposed methodology, a case that assembles computer with various options was studied.
Vertically averaged approaches for CO<sub>2</sub> migration with solubility trapping (2011)

The long‐term storage security of injected carbon dioxide (CO 2 ) is an essential component of geological carbon sequestration operations. In the postinjection phase, the mobile CO 2 plume migrates in large part because of buoyancy forces, following the natural topography of the geological formation. The primary trapping mechanisms are capillary and solubility trapping, which evolve over hundreds to thousands of years and can immobilize a significant portion of the mobile CO 2 plume. However, both the migration and trapping processes are inherently complex, spanning multiple spatial and temporal scales. Using an appropriate model that can capture both large‐ and small‐scale effects is essential for understanding the role of these processes on the long‐term storage security of CO 2 sequestration operations. Traditional numerical models quickly become prohibitively expensive for the type of large‐scale, long‐term modeling that is necessary for characterizing the migration and immobilization of CO 2 during the postinjection period. We present an alternative modeling option that combines vertically integrated governing equations with an upscaled representation of the dissolution‐convection process. With this approach, we demonstrate the effect of different modeling choices for typical large‐scale geological systems and show that practical calculations can be performed at the temporal and spatial scales of interest.
Conjugates of Enkephalin Analogs: Synthesis and Discrimination of μ and δ Opioid Receptors Based on Membrane Compartment Concept (2009)

A series of conjugated cyclic and linear enkephalin analogs, Tyr-c[D-A2bu-Gly-Phe-Asp(NH-X)], where X = methyl, stearyl or<TEX>$ PEG_350$</TEX>, and Tyr-D-Ala-Gly-Phe-Cys(S-X), where X = methyl, octyl, or farnesyl, were synthesized in solution to investigate the receptor selectivity of opioids based on Schwyzer's membrane compartment <TEX>$concepts.^{5,6}$</TEX> Cyclizations of the target compounds were achieved in high yields (> 60%) employing BOP, <TEX>$NaHCO_3$</TEX> in DMF despite the steric hindrance of the bulky pendant groups. In the binding assay, the hydrophobic fatty acyl conjugates retained <TEX>$\mu$</TEX>-receptor selectivity. The unsaturated farnesyl conjugate exhibited the increased binding affinity than the saturated stearyl conjugate for both <TEX>$\mu$</TEX>-and <TEX>$\delta$</TEX>-opioid receptors. The PEG conjugates displayed the <TEX>$\delta$</TEX>-receptor selectivity. The low molecular weight <TEX>$PEG_350$</TEX> conjugate exhibited the increase selectivity than the high molecular weight <TEX>$PEG_5000$</TEX> conjugate to the <TEX>$\delta$</TEX>-receptor. The results of this study support the membrane compartment concepts.
Robust and passive model order reduction for circuits containing susceptance elements (2003)

Numerous approaches have been proposed to address the overwhelming modeling problems that result from the emergence of magnetic coupling as a dominant performance factor for ICs and packaging. Firstly, model order reduction (MOR) methods have been extended to robustly capture very high frequency behaviors for large RLC systems via methods such as PRIMA with guaranteed passivity. In addition, new models of the magnetic couplings in terms of susceptance (inverse of inductance) have shown great promise for robust sparsification of otherwise intractable inductance coupling-matrix problems. However, model order reduction via PRIMA for circuits that include susceptance elements does not guarantee passivity. Moreover, susceptance elements are incompatible with the path tracing algorithms that provide the fundamental runtime efficiency of RICE. In this paper, a novel MOR algorithm, SMOR, is proposed as an extension of ENOR which exploits the matrix properties of susceptance-based circuits for runtime efficiency, and provides for a numerically stable, provably passive MOR using a new orthonormalization strategy.
Genetic testing in hereditary colorectal cancer: indications and procedures (1999)

Approximately 25% of colorectal cancers occur in younger individuals or those with a personal or family history of the disease, suggesting a heritable susceptibility. The minority of these cases are accounted for by one of the well-described hereditary colorectal cancer syndromes, familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC). The recent identification and cloning of the genes responsible for FAP and HNPCC, along with other colon cancer susceptibility genes, has led to the wide-spread availability of genetic testing for hereditary colorectal cancer. Genetic testing raises clinical, ethical, legal, and psychosocial questions that must urgently be discussed. This review highlights areas of knowledge and uncertainty about genetic predisposition testing for colorectal cancer and provides clinicians with practical recommendations regarding the proper indications and procedures for this testing.