gebhart/patrepeval huggingface dataset:
Aerodynamic performance and characteristic of vortex structures for Darrieus wind turbine. II. The relationship between vortex structure and aerodynamic performance (2014)

In this paper, transient computational fluid dynamics (CFD) simulations of a straight-bladed Darrieus type vertical axis wind turbine were performed by means of an in-house CFD code. The Spalart-Allmaras turbulence model was implemented in the numerical code for the turbulence. Particular emphasis was placed on effect of interaction between vortices and blades on the aerodynamic performance of the simulated turbine at different tip speed and solidity ratios. The obtained results suggested that vortices were shed from previous blade passages and the close encounter of a rotor blade with these vortices can have a considerable impact on power coefficient of the simulated turbine during operation at different tip speed ratios. As a result, possible reasons for the changes in the behavior of this type of turbine due to the variation of tip speed ratio and solidity were proposed.
The Neurobehavioural Effects of Kava (2002)

Kava is effective in the treatment of tension and anxiety. There may be risk-factors for severe motor and psychiatric responses to kava use, although these are not well-understood. Given the increasingly widespread use of kava, further investigation is necessary to gain an understanding of its immediate neuropsychiatric effects and long-term cognitive effects.
Crosstalk of the Insulin-Like Growth Factor Receptor with the Wnt Signaling Pathway in Breast Cancer (2015)

The insulin-like growth factor system has long been considered a pathway that promotes cell proliferation, survival, and transformation, and is thus a promoter of tumorigenesis. However, recent failure of clinical trials for IGF-1R inhibitors reveals the need for a better understanding of how this pathway functions in specific tumor subtypes. Ongoing studies are designed to uncover biomarkers and downstream targets to enhance therapeutic strategies. Other approaches in specific tumor models reveal complex interactions between IGF signaling and other tumor initiating pathways. Here, we review relevant background and recent studies suggesting that inhibiting the IGF-1R can amplify Wnt and Notch signaling pathways in a model of triple negative breast cancer.
Vorwort (1976)

Am 3. Oktober 1976 findet die Wahl zum 8. Deutschen Bundestag statt. Mehr als 40 Millionen Bundesbürger sind an diesem Tage aufgerufen, durch ihre Stimmabgabe eine wichtige Aufgabe bei der Teilhabe am politischen Entscheidungsprozeß wahrzunehmen.
Epigenetic Regulation of Estrogen Receptor α Gene Expression in the Mouse Cortex during Early Postnatal Development (2009)

Estrogens play a critical role in brain development by acting on areas that express estrogen receptors. In the rodent cortex, estrogen receptor alpha (ER alpha) mRNA expression is high early in postnatal development but declines starting at postnatal day (PND) 10 and is virtually absent in the adult cortex. The mechanisms controlling this regulation are largely unknown. Methylation is important for gene silencing during development in many tissues, including the brain. In the present study, we examined the methylation status of ER alpha 5' untranslated exons during early postnatal development in male and female mice using methylation-specific PCR and pyrosequencing. Several regions of ER alpha promoter displayed a significant increase in methylation at PND 18 and 25 compared with PND 4. DNA methyltransferases (DNMT) are important for the initiation and maintenance of methylation. Real-time PCR showed that DNMT3A, the de novo DNMT peaked at PND 10 and was decreased by PND 25. DNMT1, which is important for maintenance of methylation, increased across development and stayed high in adult cortex. The methyl-CpG-binding protein 2 (MeCP2) is also important for stabilization of methylation. A chromatin immunoprecipitation assay showed a correlation between association of MeCP2 with ER alpha promoter and the increase in methylation and decrease in ER alpha expression after PND 10. In mice containing a mutant MeCP2 protein, ER alpha mRNA expression and promoter methylation patterns across development were different compared with wild-type mice. These data suggest that methylation of ER alpha promoters regulates ER alpha mRNA expression in the cortex during postnatal development in a MeCP2-dependent fashion.
Efficient bit-level systolic array implementation of FIR and IIR digital filters (1988)

Bit-level systolic architectures based on an inner-product computation scheme for finite-impulse response (FIR) and infinite-impulse-response (IIR) digital are presented. The FIR filter structure is optimized in the sense that for a given clock rate, both the utilization efficiency and average throughput are maximized. The IIR filter structure has approximately the same utilization efficiency and throughput rate as previous related techniques for processing a single data stream (channel), but it allows two data streams to be processed concurrently to double the performance. This feature makes the IIR system attractive for use in applications where multiple filtering and particularly bandpass analysis are required.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in Crohn's disease (2006)

Apoptosis of active T lymphocytes constitutes a major control mechanism of immune homeostasis and tolerance. In Crohn's disease, abnormal activation of mucosal T lymphocytes against enteric bacteria is the key event triggering intestinal inflammation. Resistance of lymphocytes to apoptosis has been proposed as the pathogenetic defect. We examined the influence of bacteria-mucosa interactions on apoptosis of mucosal T lymphocytes. Ileal specimens were obtained at surgery from 12 patients with Crohn's disease. Mucosal explants from each specimen were cultured with nonpathogenic Escherichia coli ATCC 35345, Lactobacillus casei DN-114 001, or no bacteria. Cytokine release was measured in supernatant, and mononuclear cells were isolated for phenotypic characterization and Bcl-2 family protein expression. Coculture of inflamed tissue with L. casei significantly reduced the release of interleukin (IL)-6 and tumor necrosis factor alpha (P < 0.05). In addition, coculture with L. casei significantly reduced the number of T cells displaying the IL-2 receptor in the lamina propria. Expression of the antiapoptotic protein Bcl-2 in lamina propria lymphocytes was also reduced after coculture with L. casei, and the percentage of deoxyuridine triphosphate nick-end labeling positive lymphocytes increased. The nonpathogenic E. coli strain had no significant effect. In conclusion, L. casei reduces the number of activated T lymphocytes in the lamina propria of Crohn's disease mucosa. A balanced, local microecology may restore immune homeostasis.
Patient-Specific Prediction of Coronary Plaque Growth From CTA Angiography: A Multiscale Model for Plaque Formation and Progression (2012)

Computational fluid dynamics methods based on in vivo 3-D vessel reconstructions have recently been identified the influence of wall shear stress on endothelial cells as well as on vascular smooth muscle cells, resulting in different events such as flow mediated vasodilatation, atherosclerosis, and vascular remodeling. Development of image-based modeling technologies for simulating patient-specific local blood flows is introducing a novel approach to risk prediction for coronary plaque growth and progression. In this study, we developed 3-D model of plaque formation and progression that was tested in a set of patients who underwent coronary computed tomography angiography (CTA) for anginal symptoms. The 3-D blood flow is described by the Navier-Stokes equations, together with the continuity equation. Mass transfer within the blood lumen and through the arterial wall is coupled with the blood flow and is modeled by a convection-diffusion equation. The low density lipoprotein (LDL) transports in lumen of the vessel and through the vessel tissue (which has a mass consumption term) are coupled by Kedem-Katchalsky equations. The inflammatory process is modeled using three additional reaction-diffusion partial differential equations. A full 3-D model was created. It includes blood flow and LDL concentration, as well as plaque formation and progression. Furthermore, features potentially affecting plaque growth, such as patient risk score, circulating biomarkers, localization and composition of the initial plaque, and coronary vasodilating capability were also investigated. The proof of concept of the model effectiveness was assessed by repetition of CTA, six months after.
Ionic strength effects on electrophoretic focusing and separations (2010)

We present a numerical and experimental study of the effects of ionic strength on electrophoretic focusing and separations. We review the development of ionic strength models for electrophoretic mobility and chemical activity and highlight their differences in the context of electrophoretic separation and focusing simulations. We couple a fast numerical solver for electrophoretic transport with the Onsager-Fuoss model for actual ionic mobility and the extended Debye-Huckle theory for correction of ionic activity. Model predictions for fluorescein mobility as a function of ionic strength and pH compare well with data from CZE experiments. Simulation predictions of preconcentration factors in peak mode ITP also compare well with the published experimental data. We performed ITP experiments to study the effect of ionic strength on the simultaneous focusing and separation. Our comparisons of the latter data with simulation results at 10 and 250 mM ionic strength show the model is able to capture the observed qualitative differences in ITP analyte zone shape and order. Finally, we present simulations of CZE experiments where changes in the ionic strength result in significant change in selectivity and order of analyte peaks. Our simulations of ionic strength effects in capillary electrophoresis compare well with the published experimental data.
Specific N‐terminal interactions of the <i>Escherichia coli</i> SeqA protein are required to form multimers that restrain negative supercoils and form foci (2005)

The Escherichia coli SeqA protein binds preferentially to hemimethylated DNA and is required for inactivation (sequestration) of newly formed origins. A mutant SeqA protein, SeqA4 (A25T), which is deficient in origin sequestration in vivo, was found here to have lost the ability to form multimers, but could bind as dimers with wild-type affinity to a pair of hemimethylated GATC sites. In vitro, binding of SeqA dimers to a plasmid first generates a topology change equivalent to a few positive supercoils, then the binding leads to a topology change in the "opposite" direction, resulting in a restraint of negative supercoils. Binding of SeqA4 mutant dimers produced the former effect, but not the latter, showing that a topology change equivalent to positive supercoiling is caused by the binding of single dimers, whereas restraint of negative supercoils requires multimerization via the N-terminus. In vivo, mutant SeqA4 protein was not capable of forming foci observed by immunofluorescence microscopy, showing that N-terminus-dependent multimerization is required for building SeqA foci. Overproduction of SeqA4 led to partially restored initiation synchrony, indicating that origin sequestration may not depend on efficient higher-order multimerization into foci, but do require a high local concentration of SeqA.
Aspects of the P-Norm Model of Information Retrieval: Syntactic Query Generation, Efficiency, and Theoretical Properties (1990)

A practical information retrieval system must be easy to use by untrained users, and it must provide prompt responses to a user's search requests. In this thesis, these practical aspects of the p-norm model of information retrieval are explored. In addition, a study of theoretical properties of the p-norm model is presented. A syntactic method for generating p-norm queries from parse trees generated by the PLNLP syntactic analyzer is presented. The effectiveness of the syntactically generated queries is shown to be comparable to the effectiveness of manually constructed queries, and much better than that of statistically generated queries. The efficiency of a p-norm retrieval is significantly improved with a new p-norm retrieval algorithm which evaluates the entire document collection in one recursive traversal of the query tree. This algorithm is compared against the straightforward algorithm, which requires a traversal of the query tree for each document that is evaluated. The new algorithm is shown to be better both asymptotically and experimentally. The infinity-one model is introduced as a means of approximating the p-norm model without requiring exponentiation. Experimental results show that infinity-one retrieval is essentially as effective as p-norm retrieval, but much faster. List pruning methods for further efficiency improvements are also introduced and are shown to reduce retrieval time significantly without affecting the precision of top-ranked documents. The retrieval time of the infinity-one model with list pruning is shown to be comparable to that of pure Boolean retrieval. A theoretical study is also presented in which certain Boolean algebra properties, such as associativity, are shown to be unsatisfiable by any extended Boolean system with weak operators. The p-norm model is shown to satisfy all those properties that can be satisfied. In addition, the p-norm model is evaluated with respect to the Waller-Kraft wish list for extended Boolean systems.
Cloning of a Mutable <i>bz2</i> Allele of Maize by Transposon Tagging and Differential Hybridization (1987)

Sequences of Bronze2 (Bz2), a maize gene which is required for the synthesis of the purple pigment anthocyanin, have been cloned by combining the techniques of transposon tagging and differential hybridization. First, a mutable bz2 allele (bz2-mu1) was recovered from a Mutator line. The mutation was assumed to result from an insertion of the transposable element Mutator (Mu), which is found in 10-60 copies in Mutator lines. A library was prepared using DNA isolated from bz2-mul, and a small bank of Mu-specific candidate clones was selected. Because much is known about the genetic requirements for the synthesis of anthocyanin in different tissues, we were able to identify the bz2 clone based on its hybridization to RNA isolated from different bz2 mutants. Only one clone hybridized to RNA isolated from the husks of purple (Bz2, B, Pl) plants but not to RNA isolated from the husks of green (an-bz2-6923, b, pl) plants. Further confirmation was provided by the hybridization pattern of the clone on blots containing DNA from other bz2 mutants. We present a restriction map of the clone, indicating the location and orientation of the 1.4-kbp Mu insert. We identify the transcribed region, the direction of transcription and the location of the 1.4-kbp Mu insert in an independently isolated mutant, bz2-mu2.
The Canadian Reindeer Project (1968)

The reindeer experiment in the Mackenzie Districtf continues as the Canadian Reindeer Project, the contract for which is held by Sven Johansson, an immigrant from Sweden where he had gained experience in reindeer husbandry at Jokkmok and elsewhere. He had been employed as project manager in March 1963 for two years by A. J. Oeming, who was then sole contractor, and in 1965 he took up the contract himself for one year; it has been renewed annually since then. Project headquarters remain at Reindeer Station. Responsibility for the Project's support and over-all control lies with the Federal Department of Indian Affairs and Northern Development. The Inuvik Research Laboratory, 30 miles south of Reindeer Station, provides valuable technical assistance.
Monoclonal Antibodies and a Heterobifunctional Reagent: A Novel Approach to the Vectorial Labeling of Selected Membrane Proteins (1982)

Many applications exist and others are envisioned for the chemical coupling of macromolecules to membrane proteins on the surface of mammalian cells. The ability to use antibody as a means to label and subsequently to follow the distribution of cell surface proteins is reported here. A new procedure is outlined for covalently coupling monoclonal antibodies to thiol-containing membrane proteins. The key reagent in the coupling reaction is the commercially available heterobifunctional reagent N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP). The coupling proceeds in a simple two-step reaction in aqueous medium under very mild conditions. This results in a very efficient and stable attachment of anti-hapten antibodies to a selected set of cell surface proteins without any loss in cell viability and without denaturing the antibody molecule. The hapten-binding activity of the antibody is exploited to monitor the re-distribution of the antibody-labeled cell surface proteins periodically after the coupling reaction. The hapten binding activity can also be utilized to isolate membrane macromolecules via affinity chromatography.
Comparison of the Corneal Endothelium in an American and a Japanese Population (1985)

We compared the corneal endothelial morphology between an age-matched population of American and Japanese persons. Endothelial specular photographs were subjected to a computer-assisted morphometry of the area and shape of individual cells. The endothelium in the Japanese population showed a significantly higher cell density when compared with an age-matched American population. However, there was no difference in the degree of variations in cell area and cell shape between the two populations. The results suggest that higher endothelial cell density in the Japanese population could be related to the lower incidence of aphakic bullous keratopathy in the Japanese population.
Horticultural Uses of Municipal Solid Waste Composts (1993)

Composting of municipal solid waste (MSW) has received renewed attention as a result of increasing waste disposal costs and the environmental concerns associated with using landfills. Sixteen MSW composting facilities are currently operating in the United States, with many more in the advanced stages of planning. A targeted end use of the compost is for horticultural crop production. At the present time, quality standards for MSW composts are lacking and need to be established. Elevated heavy metal concentrations in MSW compost have been reported; however, through proper sorting and recycling prior to composting, contamination by heavy metals can be reduced. Guidelines for safe metal concentrations and fecal pathogens in compost, based on sewage sludge research, are presented. The compost has been shown to be useful in horticultural crop production by improving soil physical properties, such as lowering bulk density and increasing water-holding capacity. The compost can supply essential nutrients to a limited extent; however, supplemental fertilizer, particularly N, is usually required. The compost has been used successfully as a sphagnum peat substitute for container media and as a seedbed for turf production. High soluble salts and B, often leading to phytotoxicity, are problems associated with the use of MSW compost. The primary limiting factor for the general use of MSW compost in horticultural crop production at present is the lack of consistent, high-quality compost.
Hardware implementation of convolutional STDP for on-line visual feature learning (2017)

We present a highly hardware friendly STDP (Spike Timing Dependent Plasticity) learning rule for training Spiking Convolutional Cores in Unsupervised mode and training Fully Connected Classifiers in Supervised Mode. Examples are given for a 2-layer Spiking Neural System which learns in real time features from visual scenes obtained with spiking DVS (Dynamic Vision Sensor) Cameras.
Remarks on Contribution to the Development of ALGOL (1966)

Geotrichum species have been rarely reported as the cause of sepsis, disseminated infection in immunosuppressed patients. The patient we describe developed indolent endophthalmitis four months after her routine right eye cataract surgery. The intraoperative sample from right vitreous fluid grew Geotrichum candidum. The patient underwent vitrectomy, artificial lens explantation and intravitreal injection of amphotericin B followed by oral voriconazole. Despite these interventions, she underwent enucleation. This is the first published case of Geotrichum candidum endophthalmitis.
Development of Machine Vision Based Poultry Behavior Analysis System (2003)

Environmental controllers are used in most current production poultry houses. The currentcontrollers match house temperature to predefined temperature settings. In this project, an image analysissystem was developed to extract bird temperature response and feeding behavior from a commercial poultrysetting. The algorithm evaluated flock aggregate behavior rather than track specific birds. Image subtractionand masking was used to separate the birds from the background. Image morphology was used to size filterthe birds from the background. Results are presented in the text.
Diagnostic Real-Time PCR for Detection of <i>Salmonella</i> in Food (2004)

A robust 5' nuclease (TaqMan) real-time PCR was developed and validated in-house for the specific detection of Salmonella in food. The assay used specifically designed primers and a probe target within the ttrRSBCA locus, which is located near the Salmonella pathogenicity island 2 at centisome 30.5. It is required for tetrathionate respiration in Salmonella. The assay correctly identified all 110 Salmonella strains and 87 non-Salmonella strains tested. An internal amplification control, which is coamplified with the same primers as the Salmonella DNA, was also included in the assay. The detection probabilities were 70% when a Salmonella cell suspension containing 10(3) CFU/ml was used as a template in the PCR (5 CFU per reaction) and 100% when a suspension of 10(4) CFU/ml was used. A pre-PCR sample preparation protocol including a preenrichment step in buffered peptone water followed by DNA extraction-purification was applied when 110 various food samples (chicken rinses, minced meat, fish, and raw milk) were investigated for Salmonella. The diagnostic accuracy was shown to be 100% compared to the traditional culture method. The overall analysis time of the PCR method was approximately 24 h, in contrast to 4 to 5 days of analysis time for the traditional culture method. This methodology can contribute to meeting the increasing demand of quality assurance laboratories for standard diagnostic methods. Studies are planned to assess the interlaboratory performance of this diagnostic PCR method.
New Procedures for the Preparation of Isoflavones with Unsubstituted Ring A (1992)

Abstract Isoflavones with unsubstituted ring A have been synthesized either by the ring closure of 2-hy-droxydeoxybenzoins or by the dehydroxylation of 7-hy-droxyisoflavones. 7-Mercaptoisoflavones have also been prepared.
Power module for a wireless sensor node of a power line monitoring system (2011)

For a wireless sensor node of an overhead power line monitoring system a power module was developed using the electrostatic field around the conductor to supply the sensor system. Special requirements in functionality, reliability and the limited accessibility at the power line result in the development of a specific energy management strategy. First prototypes of the power module were realized and tested under laboratory conditions. The following contribution presents theoretical considerations to the energy availability using the aimed method, the design of the energy management strategy and results from measurements with the prototype in a high voltage laboratory.