gebhart/patrepeval huggingface dataset:
A Modeling Framework for Integrated Distributed Systems Fault Management (1996)

This paper describes a modeling framework for integrated fault management of distributed systems. The model integrates all different layers of distributed systems such as application, system, and network layer in a single, consistent view. This enables generic management applications to perform their tasks across layer boundaries of the distributed system without knowledge about the specific details. The focus is on fault management issues. Dependencies between resources critical for the availability of the distributed system are modeled using relationships. Generic fault management applications are hereby enabled to determine the root cause of a distributed system failure automatically. The SAP R/3 application serves as an example to demonstrate the capabilities of the modeling framework.
Performance Evaluation of Spectrum Sharing Algorithms in Single and Multi Operator Scenarios (2011)

The increasing demand of indoor broadband access encourages the diffusion of the "home base stations", known as femtocells. Their self installation nature envisages interference problems due to a possible overload of local femtocell installations in the same area. To reduce the interference among femtocells we propose and analyze the performance of a dynamic frequency selection strategy, according to which each femtocell is able to select one of the possible frequencies available from all the operators in order to experience the best Signal-to-Interference Ratio (SIR). We assume that mobile operators share their requency bands allowing femtocells subscribed to a certain operator to exploit the frequency resources of other operators. In this paper we evaluate the performance in terms of allowed number of active femtocells per operator when the channels available from operators increase. It is observed that the application of the proposed Dynamic Frequency Selection (DFS) algorithm with band sharing allows single operator to significantly improve the number of active femtocells deployed in the area with respect to the non band sharing case, i.e. a Spectrum Sharing Gain is achieved.
Astaxanthin Inhibits JAK/STAT-3 Signaling to Abrogate Cell Proliferation, Invasion and Angiogenesis in a Hamster Model of Oral Cancer (2014)

Identifying agents that inhibit STAT-3, a cytosolic transcription factor involved in the activation of various genes implicated in tumour progression is a promising strategy for cancer chemoprevention. In the present study, we investigated the effect of dietary astaxanthin on JAK-2/STAT-3 signaling in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis model by examining the mRNA and protein expression of JAK/STAT-3 and its target genes. Quantitative RT-PCR, immunoblotting and immunohistochemical analyses revealed that astaxanthin supplementation inhibits key events in JAK/STAT signaling especially STAT-3 phosphorylation and subsequent nuclear translocation of STAT-3. Furthermore, astaxanthin downregulated the expression of STAT-3 target genes involved in cell proliferation, invasion and angiogenesis, and reduced microvascular density, thereby preventing tumour progression. Molecular docking analysis confirmed inhibitory effects of astaxanthin on STAT signaling and angiogenesis. Cell culture experiments with the endothelial cell line ECV304 substantiated the role of astaxanthin in suppressing angiogenesis. Taken together, our data provide substantial evidence that dietary astaxanthin prevents the development and progression of HBP carcinomas through the inhibition of JAK-2/STAT-3 signaling and its downstream events. Thus, astaxanthin that functions as a potent inhibitor of tumour development and progression by targeting JAK/STAT signaling may be an ideal candidate for cancer chemoprevention.
Formation of surface-grafted polymeric amphiphilic coatings comprising ethylene glycol and fluorinated groups and their response to protein adsorption (2009)

Amphiphilic polymer coatings were prepared by first generating surface-anchored polymer layers of poly(2-hydroxyethyl methacrylate) (PHEMA) on top of flat solid substrates followed by postpolymerization reaction on the hydroxyl terminus of HEMA's pendent group using three classes of fluorinating agents, including organosilanes, acylchlorides, and trifluoroacetic anhydride (TFAA). The distribution of the fluorinated groups inside the polymer brushes was assessed by means of a suite of analytical probes, including contact angle, ellipsometry, infrared spectroscopy, atomic force microscopy, and near-edge x-ray absorption fine structure spectroscopy. While organosilane modifiers were found to reside primarily close to the tip of the brush, acylchlorides penetrated deep inside PHEMA thus forming random copolymers P(HEMA-co-fHEMA). The reaction of TFAA with the PHEMA brush led to the formation of amphiphilic diblocks, PHEMA-b-P(HEMA-co-fHEMA), whose bottom block comprised unmodified PHEMA and the top block was made of P(HEMA-co-fHEMA) rich in the fluorinated segments. This distribution of the fluorinated groups endowed PHEMA-b-P(HEMA-co-fHEMA) with responsive properties; while in hydrophobic environment P(HEMA-co-fHEMA) segregated to the surface, when in contact with a hydrophilic medium, PHEMA partitioned at the brush surface. The surface activity of the amphiphilic coatings was tested by studying the adsorption of fibrinogen (FIB). While some FIB adsorption occurred on most coatings, the ones made by TFAA modification of PHEMA remained relatively free of FIB.
A myocardial Nox2 containing NAD(P)H oxidase contributes to oxidative stress in human atrial fibrillation (2005)

Abstract—Human atrial fibrillation (AF) has been associated with increased atrial oxidative stress. In animal models, inhibition of reactive oxygen species prevents atrial remodeling induced by rapid pacing, suggesting that oxidative stress may play an important role in the pathophysiology of AF. NAD(P)H oxidase is a major source of superoxide in the cardiovascular system; however, whether this enzyme contributes to atrial oxidative stress in AF remains to be elucidated. We investigated the sources of superoxide production (using inhibitors and substrates of a range of oxidases, RT-PCR, immunofluorescence, and immunoblotting) in tissue homogenates and isolated atrial myocytes from the right atrial appendage (RAA) of patients undergoing cardiac surgery (n54 in sinus rhythm [SR] and 15 in AF). A membrane-bound gp91phox containing NAD(P)H oxidase in atrial myocytes was the main source of atrial superoxide production in SR and in AF. NADPH-stimulated superoxide release from RAA homogenates was significantly increased in patients with AF in the absence of changes in mRNA expression of the p22phox and gp91phox subunits of the NAD(P)H oxidase. In contrast with findings in SR patients, NO synthases (NOSs) contributed significantly to atrial superoxide production in fibrillating atria, suggesting that increased oxidative stress in AF may lead to NOS “uncoupling. ” These findings indicate that a myocardial NAD(P)H oxidase and, to a lesser extent, dysfunctional NOS contribute significantly to superoxide production in the fibrillating human atrial myocardium and may play an important role in the atrial oxidative injury and electrophysiological remodeling observed in patients with AF. (Circ Res.
Biotechnology of maltose syrup production (1987)

Caracteristiques et importance. Enzymes utilisees pour la production de sirops de maltose. Procedes de production: liquefaction de l'amidon, saccharification de l'amidon liquefie. Immobilisation d'enzymes. Cristallisation du maltose. Produits obtenus a partir des sirops de maltose (sirop de maltose hydrogenes, maltulose, melange avec autres sirops de sucre)
Cloning of cDNA encoding human placental protein 12(PP12): binding protein for IGF I and somatomedin (1988)

By N-terminal sequence comparison it was shown that the placental protein 12 (PP12) is homologous to the IGF I (insulin-like growth factor) and somatomedin binding protein. Starting with an antibody raised against PP12 the authors have screened cDNA libraries from human placenta. Two cDNA clones were identified with an open reading frame encoding a hydrophobic leader peptide consisting of 25 aa and the mature protein of 234 aa (MW 25 270). The MW and the amino acids composition are in good agreement to the data of Bohn and Kraus. The protein sequence shows no N-linked glycosylation site. The cDNA encodes 18 Cys-residues, which may explain the wide discrepancy in the reported MW of the PP12 protein. The stop codon at position 928 is followed by 566 nt of untranslated region including the poly(A) addition site AATAAA 18 nt upstream of poly(A).
Composite optical waveguide composed of a tapered film of bromothymol blue evaporated onto a potassium ion–exchanged waveguide and its application as a guided wave absorption–based ammonia-gas sensor (2001)

For what is the first time to our knowledge, we have successfully evaporated a tapered film of bromothymol blue (BTB) onto a potassium ion-exchanged (PIE) waveguide to form a composite optical waveguide (COWG) for trace-ammonia detection. The BTB film has a high refractive index (1.69) and a smooth surface and is transparent to a 633-nm laser beam in air. In the COWG structure, the BTB film serves as a single-mode waveguide, and adiabatic transition of the TE(0) mode was realized between the BTB waveguide and the PIE waveguide with both BTB tapers. In the presence of ammonia, the BTB film changes color from yellow to blue, which causes absorption of the 633-nm guided wave. Our experimental results demonstrate that such a guided wave absorption-based ammonia-gas sensor is much more sensitive than one based on evanescent-wave absorption. A detection limit of part in 10(9) of ammonia has been realized for a BTB film-PIE glass COWG.
Texture analysis for estimating spatial variability and anisotropy in planar stochastic structures (1996)

Some operators from the theory of texture image analysis are used to obtain a new method for the evaluation of anisotropy in planar stochastic structures. A local gradient function provides information on local anisotropy and its variability, from 2-D density images for foil ma- terials like polymer sheets, nonwoven textiles and paper. Such images can be captured by radiography or light transmission; results are re- ported for a range of paper structures. The method has potential for on-line application to monitoring and control of anisotropy and its vari- ability, as well as local density itself, in continuous manufacturing pro- cesses. © 1996 Society of Photo-Optical Instrumentation Engineers.
An <i>Escherichia coli</i> plasmid vector system for production of streptavidin fusion proteins: Expression and bioselective adsorption of streptavidin‐β‐galactosidase (1994)

Covalently immobilized biotin was used as a biospecific adsorbant to investigate the application of streptavidin as an affinity domain for simultaneous purification and immobilization of recombinant proteins. A streptavidin-beta-galactosidase fusion protein was constructed and tested as a model system. The gene for streptavidin from Streptomyces avidinii was modified by polymerase chain reaction to mutate the stop codon and to facilitate cloning into an Escherichia coli expression vector yielding a versatile plasmid with 37 unique restriction enzyme sites at the 3' end. E. coli beta-galactosidase was cloned in-frame to the streptavidin gene. Analysis of lysates of induced recombinant E. coli cells by SDS-PAGE and Western blots indicated that the 133.6-kDa fusion protein was expressed. Sulfosuccinimidyl-6-(biotinamido) hexanoate was covalently immobilized on 3-aminopropyl-controled-pore glass beads. Exposure of recombinant cell lysates to this support indicated that streptavidin-beta-galactosidase was bioselectively adsorbed. The resulting biocatalyst contained 300 mg protein per gram of beads and exhibited a specific activity of 306 betamol/min per milligram protein with o-nitrophenyl-beta-D-galactopyranoside as substrate corresponding to approximately 50% of that observed for commercially pure E. coli beta-galactosidase.
Carbon nanotubes decorated with Pt nanoparticles via electrostatic self-assembly: a highly active oxygen reduction electrocatalyst (2010)

Carbon nanotubes (CNTs) are noncovalently functionalized with poly(allylamine hydrochloride) (PAH) and then employed as the support of Pt nanoparticles. X-Ray photoelectron spectroscopy confirms the successful functionalization of CNTs with PAH. The negatively charged Pt precursors are adsorbed on positively charged PAH-wrapping CNTs surface via electrostatic self-assembly and then in situ reduced in ethylene glycol. X-Ray diffraction and transmission electron microscope images reveal that Pt nanoparticles with an average size of ∼2.6 nm are uniformly dispersed on CNT surface. Pt/PAH-CNTs exhibit unexpectedly high activity towards oxygen reduction reaction, which can be attributed to the large electrochemical surface area of Pt nanoparticles. It also shows enhanced electrochemical stability due to the structural integrity of PAH-CNTs. This provides a facile approach to synthesize CNTs-based nanoelectrocatalysts.
MSDU-based ARQ scheme for IP-level performance maximization (2005)

Automatic repeat request (ARQ) is one of the effective techniques against the transmission error at the medium access control (MAC) layer. An erroneous MAC protocol data unit (MPDU) can be typically retransmitted within a given limit. In order to improve the IP-level performance, which directly affects the user-perceived quality-of-service (QoS), we propose a different ARQ strategy, called 'MSDU-based' scheme, with simple and minor modification from the existing ARQ concept. We evaluate the analytical IP-level performance of both the conventional and proposed scheme.
Effects of the wall boundary conditions of a showerhead plasma reactor on the uniformity control of RF plasma deposition (2017)

Technical difficulties hinder the formation of uniform deposition profiles near the electrode edge during a deposition in a showerhead capacitively coupled plasma (CCP) reactor. The discharge structure, gas flow, and radial distribution of the source gas outward from the electrode edge are subject to change significantly, which in turn affects the spatial distributions of the radical fluxes toward the electrode. To control the local non-uniformity of deposition profiles in the SiH4/NH3/N2/He CCP discharges for a hydrogenated silicon nitride (SiNxHy) film, the effects of the reactor components―including the sidewall boundary condition, electrode spacing, and showerhead design―were investigated using an axisymmetric fluid model. When the sidewall is electrically grounded, the deposition rate profiles of the SiNxHy film remain consistently convex (in which the deposition rate at the reactor center is locally much higher than that near the electrode edge), regardless of electrode spacing. However, when the sidewall surface is dielectric, the deposition rate profile can be transformed between a convex and a concave shape (in which the deposition rate at the reactor center is locally much lower than that near the electrode edge) by varying electrode spacing. The showerhead design also enables the modification of edge deposition profiles by redistribution of the local depletion rate of radicals. The simulation results agree very well with the experimental measurement.
Characterization of Diphtheria Toxin-induced Lesions in Liposomal Membranes (1989)

Diphtheria toxin interaction with membranes has been studied by following the release of a fluorescent dye (calcein) encapsulated within large unilamellar vesicles. Results showed that diphtheria toxin induced temperature- as well as pH-dependent permeability changes in these model membranes. Interestingly, insertion of the "channel-forming" B domain was not sufficient for calcein release, since dye release from vesicles composed of dimyristoyllecithin:cholesterol:dicetylphosphate 4:3:0.8) was completely inhibited at low temperatures which permitted B insertion. Rather, the temperature dependence of calcein release from and A domain insertion into dimyristoyllecithin:cholesterol:dicetyl phosphate vesicles suggest some relationship between "channel formation" and fragment A translocation across membranes. However, the nature of the toxin channel is called into question by our observations that channel size, in addition to activity, was pH-dependent. On the basis of these experiments, it is proposed that the toxin "channel" is the result of localized perturbations in the lipid bilayer at the interface between lipids and inserted toxin molecules that are sufficiently large in fluid membranes at low pH to allow the translocation of fragment A across the bilayer.
Mechanical and morphological study of biostable polyurethane heart valve leaflets explanted from sheep (2002)

Two novel biostable polyurethanes, designated EV3.34 and EV3.35, were used to manufacture a flexible trileaflet heart valve. The valves were implanted in the mitral position in young adult (18 month) sheep. Six valves were electively explanted at 6 months and the remaining six valves at 9 months follow-up. The leaflet material was examined by surface Fourier transform infrared spectrometry (ATR/FTIR) and scanning electron microscopy (SEM). The leaflet material was also subjected to cyclic mechanical testing and, compared with unimplanted control material, to demonstrate any change in mechanical properties during implantation. There was no degradation of functional groups detected by ATR/FTIR, although there was a slight surface enrichment of siloxane soft segment. Surface morphology of the explanted leaflet material was similar to unimplanted control material. EV3.34 demonstrated similar inelastic energy loss behavior, with no significant change in residual strain in explanted compared with control material. EV3.35 demonstrated a reduction in inelastic energy and residual strain in explanted compared with control material. There is no evidence of biodegradation of these siloxane-based polyurethanes, in functional valves up to 9 months implantation in sheep. The FTIR and SEM findings are supported by the retention of mechanical properties of the materials.
Convolutional sparse coding for face recognition (2017)

Face recognition has been an important task in pattern recognition and computer vision. Recently, sparse representation has become a popular data representation method in face recognition field. Convolutional sparse coding, which replaces the linear combination of a set of dictionary atoms with the sum of s series of mapping term convoluted with the dictionary filters, was proposed to improve the application performance of traditional sparse coding. In this paper, we apply this convolutional sparse coding method to do the face recognition. As the trained dictionary filters could capture more discriminative information in the corresponding face images, it could believed that better classification performance can be achieved. Experimental results on the face image database demonstrated the novel convolutional sparse coding algorithm can achieve better recognition rate.
Automatic Fall Detection Based on Doppler Radar Motion Signature (2011)

Falling is a common health problem for elderly. It is reported that more than one third of adults 65 and older fall each year in the United States. To address the problem, we are currently developing a Doppler radar-based fall detection system. Doppler radar sensors provide an inexpensive way to rec
Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications (2008)

Bioinformatics analysis provides a valuable platform for gene discovery and functional prediction that helps explain the activity of A. ferrooxidans in industrial bioleaching and its role as a primary producer in acidic environments. An analysis of the genome of the type strain provides a coherent view of its gene content and metabolic potential.
The role of nursing (2005)

Dementia presents with a progressive deterioration of cognitive abilities, increasing dependency on others for self-care and an emerging need for supervision. The role of nursing can be pivotal in that nurses work in a continuum of settings in which they provide care for the individual with dementia and their families. Nursing professionals have the benefit of face-to-face contact, be it in the clinic, home, or institution. The nurse may be the person who is most readily accessible and can coordinate the patient’s care needs. Nurses are a valuable resource for understanding the difficulties of caring for the patient at home. Their role may be to observe changes in health status and to communicate these changes to the other members of the health team. It may be the nurse who talks most frequently to the family providing counselling and support. As a resource for assistance in day-to-day care, nurses can identify problems and give practical advice in caring for problems ranging from bathing to catastrophic reactions (Sloane et al., 1995).
Simultaneous determination of twelve tea catechins by high-performance liquid chromatography with electrochemical detection (2001)

A high-performance liquid chromatographic method with electrochemical detection was developed for the determination of twelve tea catechins including four major catechins: epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) and epigallocatechin gallate (EGCG); four of their epimers at the C-2 position, C, GC, CG and GCG; and four methylated catechin derivatives, epigallocatechin-3-O-(3-O-methyl)gallate, gallocatechin-3-O-(3-O-methyl)gallate, epigallocatechin-3-O-(4-O-methyl)gallate and epicatechin-3-O-(3-O-methyl)gallate. These catechins were separated on an ODS C18 reversed-phase column by isocratic elution with 0.1 M NaH2PO4 buffer (pH 2.5)-acetonitrile (87:13) containing 0.1 mM EDTA.2Na. The detection limits (S/N = 3) of these catechins were approximately 10-40 pmol ml-1 at an applied voltage of 600 mV. Extracting these catechins from tea leaf powder with H2O-acetonitrile (1:1) at 30 degrees C for 40 min inhibited the epimerization at C-2 significantly from these epicatechins compared to extraction with hot water at 90 degrees C. This analytical method is sensitive to and appropriate for the simultaneous determination of various biologically active catechins in green tea.
Building an Encrypted and Searchable Audit Log. (2004)

Binding sites corresponding to 5-HT1E receptors were labelled in mouse, rat, and guinea-pig brains by using [3H]5-hydroxytryptamine ([3H]5-HT) in the presence of 5-carboxamidotryptamine (5-CT) (0.1 microM), and their distribution within the brain was studied by quantitative autoradiography. The results obtained with mouse brain show that 5-HT1E binding sites are particularly present in the cortex, caudate-putamen and claustrum, where they showed the highest density. Lower densities were measured in other regions. Saturation experiments showed that the affinity of [3H]5-HT for 5-HT1E binding sites (nanomolar range) was very similar in the different structures. The distribution of 5-HT1E binding sites was similar in rat and guinea-pig brains. In rat brain, selective lesioning of serotonergic fibres by intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT), a specific 5-HT neurotoxin, did not affect the density of 5-HT1E binding, indicating that these receptors are mainly localized on non-serotonergic neurones.