gebhart/patrepeval huggingface dataset:
Treatment outcome of 42 replanted permanent incisors with a median follow-up of 2.8 years. (2011)

Use of a strict endodontic treatment protocol after replantation minimized the risk of infection-related root resorption. The occurrence of replacement resorption was mainly influenced by the duration of the non-physiologic extraoral storage time and storage medium.
Quantitative analysis of the cysteine redoxome by iodoacetyl tandem mass tags (2017)

The redox conditions that reign inside a cell have a determining effect on a number of biological processes. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are key redox players and have been linked to a number of pathologies. They have also been shown to play an important regulating role in cell signaling events. On the proteome level, thiol groups of cysteinyl side chains constitute the major targets of ROS and RNS. A number of analytical techniques based on mass spectrometry have been developed to characterize the cysteine redoxome, often facing a number of technical challenges, mostly related to the lability, heterogeneity, and low abundance of the oxidized forms. Furthermore, any posttranslational modification (PTM) quantification method needs to take the parent protein's expression level into account. While taking all these limitations into consideration, we have developed a quantitative analytical strategy named OxiTMT, based on chemical labeling with iodoacetyl isobaric tandem mass tags (iodoTMT). OxiTMT allowed the generation of quantitative redox data that could be normalized by the protein's expression profile in up to three different conditions. The method was tested on Escherichia coli with or without an oxidative treatment. Results showed the method to be adequate for the analysis of cysteine PTMs with a good coverage of the cysteine redoxome, especially for the low abundant oxidized species. Some of the challenges that face reporter ion quantification of PTMs by mass spectrometry were also assessed. This study serves as a proof of concept of the established protocol and consequent data treatment step. The use of tandem mass tags opens the ways towards the application of the method to the study of tissues and sera. Graphical abstract OxiTMT workflow.
Statistics of short time variations of indoor radio propagation (2002)

In an indoor environment, channel variations which occur most frequently are due to the movement of personnel near the transmitting or receiving antennas and/or local movements of the terminals around a given location. Such short-time variations in the indoor radio channel are studied and determined by performing propagation experiments in line-of-sight and non-line-of-sight environments at 910 MHz. The database is divided into two classes: global short-time and local short-time variations. Global short-time variations deal with the changes in the radio channel, observed over time and space, at different locations in an area. The local short-time variations address changes induced over time, by human traffic close to the fixed transmitter/receiver or by manually shaking the antenna on its base. The statistics of RMS delay spread and the received power in the multipath profiles are computed and compared for these experimental variations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Increased CD8+ T Cell Response to Epstein-Barr Virus Lytic Antigens in the Active Phase of Multiple Sclerosis (2013)

It has long been known that multiple sclerosis (MS) is associated with an increased Epstein-Barr virus (EBV) seroprevalence and high immune reactivity to EBV and that infectious mononucleosis increases MS risk. This evidence led to postulate that EBV infection plays a role in MS etiopathogenesis, although the mechanisms are debated. This study was designed to assess the prevalence and magnitude of CD8+ T-cell responses to EBV latent (EBNA-3A, LMP-2A) and lytic (BZLF-1, BMLF-1) antigens in relapsing-remitting MS patients (n = 113) and healthy donors (HD) (n = 43) and to investigate whether the EBV-specific CD8+ T cell response correlates with disease activity, as defined by clinical evaluation and gadolinium-enhanced magnetic resonance imaging. Using HLA class I pentamers, lytic antigen-specific CD8+ T cell responses were detected in fewer untreated inactive MS patients than in active MS patients and HD while the frequency of CD8+ T cells specific for EBV lytic and latent antigens was higher in active and inactive MS patients, respectively. In contrast, the CD8+ T cell response to cytomegalovirus did not differ between HD and MS patients, irrespective of the disease phase. Marked differences in the prevalence of EBV-specific CD8+ T cell responses were observed in patients treated with interferon-β and natalizumab, two licensed drugs for relapsing-remitting MS. Longitudinal studies revealed expansion of CD8+ T cells specific for EBV lytic antigens during active disease in untreated MS patients but not in relapse-free, natalizumab-treated patients. Analysis of post-mortem MS brain samples showed expression of the EBV lytic protein BZLF-1 and interactions between cytotoxic CD8+ T cells and EBV lytically infected plasma cells in inflammatory white matter lesions and meninges. We therefore propose that inability to control EBV infection during inactive MS could set the stage for intracerebral viral reactivation and disease relapse.
Long-Span Reinforced Steel Box Culverts (1998)

A comprehensive investigation of soil–metal structure interaction for long-span deep-corrugated reinforced steel box culverts was carried out in a project sponsored by the National Research Council of Canada in 1996. Two 12-m span box culverts were erected at a Dorchester, New Brunswick, test site using two backfill densities, one structural steel plate thickness, and a minimum cover of 300 mm. These structures are the largest steel box culverts erected to date. One structure was reinforced using continuous deep-corrugated crown stiffeners, and the other was intermittently reinforced using composite concrete metal-encased stiffeners. Strain and deflection of the structure were monitored in response to static axle loads positioned at six locations on the test surface. A finite element model was then used in numerical simulations of the soil–metal structure system. The measured culvert response was then compared with results from the finite element model. A nonlinear soil-structure interaction program (NLSSIP) was used to analyze the two long-span box culverts. NLSSIP was developed specifically for long-span soil–metal culverts and has been used for structures with and without stiffeners. The box culvert test provided a definitive relationship between soil stiffness and metal structure stiffness. The test was the first that evaluated intermittently reinforced composite concrete metal-encased stiffeners relative to conventional continuous reinforcement. The performance of the two types of stiffeners is evaluated and recommendations are made for future design and installation of long-span deep-corrugated steel box culverts.
Vanadium Redox Flow Batteries Using <i>meta</i>-Polybenzimidazole-Based Membranes of Different Thicknesses (2017)

15, 25, and 35 μm thick meta-polybenzimidazole (PBI) membranes are doped with H<sub>2</sub>SO<sub>4</sub> and tested in a vanadium redox flow battery (VRFB). Their performances are compared with those of Nafion membranes. Immersed in 2 M H<sub>2</sub>SO<sub>4</sub>, PBI absorbs about 2 mol of H<sub>2</sub>SO<sub>4</sub> per mole of repeat unit. This results in low conductivity and low voltage efficiency (VE). In ex-situ tests, meta-PBI shows a negligible crossover of V<sup>3+</sup> and V<sup>4+</sup> ions, much lower than that of Nafion. This is due to electrostatic repulsive forces between vanadium cations and positively charged protonated PBI backbones, and the molecular sieving effect of PBI's nanosized pores. It turns out that charge efficiency (CE) of VRFBs using meta-PBI-based membranes is unaffected by or slightly increases with decreasing membrane thickness. Thick meta-PBI membranes require about 100 mV larger potentials to achieve the same charging current as thin meta-PBI membranes. This additional potential may increase side reactions or enable more vanadium ions to overcome the electrostatic energy barrier and to enter the membrane. On this basis, H<sub>2</sub>SO<sub>4</sub>-doped meta-PBI membranes should be thin to achieve high VE and CE. The energy efficiency of 15 μm thick PBI reaches 92%, exceeding that of Nafion 212 and 117 (N212 and N117) at 40 mA cm<sup>-2</sup>.
Structural Analysis of the Lipopolysaccharide fromChlamydia trachomatis Serotype L2 (1999)

The lipopolysaccharide (LPS) of Chlamydia trachomatis L2 was isolated from tissue culture-grown elementary bodies using a modified phenol/water procedure followed by extraction with phenol/chloroform/light petroleum. From a total of 5 x 10(4) cm2 of infected monolayers, 22.3 mg of LPS were obtained. Compositional analysis indicated the presence of 3-deoxy-D-manno-oct-2-ulopyranosonic acid (Kdo), GlcN, phosphorus, and fatty acids in a molar ratio of 2.8:2:2.1:4.5. Matrix-assisted laser-desorption ionization mass spectrometry performed on the de-O-acylated LPS gave a major molecular ion peak at m/z 1781.1 corresponding to a molecule of 3 Kdo, 2 GlcN, 2 phosphates, and two 3-hydroxyeicosanoic acid residues. The structure of deacylated LPS obtained after successive treatment with hydrazine and potassium hydroxide was determined by 600 MHz NMR spectroscopy as Kdoalpha2-->8Kdoalpha2-->4Kdoalpha2-->6D-GlcpNbeta1 -->6D-GlcpNalpha 1,4'-bisphosphate. These data, together with those published recently on the acylation pattern of chlamydial lipid A (Qureshi, N., Kaltashov, I., Walker, K., Doroshenko, V., Cotter, R. J., Takayama, K, Sievert, T. R., Rice, P. A., Lin, J.-S. L., and Golenbock, D. T. (1997) J. Biol. Chem. 272, 10594-10600) allow us to present for the first time the complete structure of a major molecular species of a chlamydial LPS.
29.2: New Photo Alignment Technology Based on •‐(4‐Chalconyloxy) Alkyl Groups (2000)

Abstract This paper describes a new photo alignment method based on the •‐(4‐Chalconyloxy) Alkyl side group with styrene units and phenylmaleimide units. We compared the proposed photo alignment method with the rubbing method and found that there was a gain in anchoring energy at the interface between the alignment film and LC. Furthermore, we found the improvement in TN cell electro‐optical characteristics when we used this new photo alignment method. We think this photo alignment method was available in practical applications.
Permeability Properties of Fruit Puree Edible Films (1996)

ABSTRACT The potential of fruit purees as edible mass transfer barriers was studied. Water vapor and oxygen permeabilities (WVP and O 2 P) of peach puree films were evaluated at different relative humidities (RH) and temperatures (T). Peach puree was not a good water barrier. Peach and apricot films exhibited lower WVPs than pear and apple films. Calcium addition, RH increases and T decreases resulted in increased WVP values for peach puree edible films. WVPs of peach films were compared with other edible and synthetic films. Peach puree films were good oxygen barriers. RH increases resulted in exponential increases in O 2 P. Most edible and many synthetic polymers showed higher O 2 Ps at equivalent conditions.
Degenerate Cases in Using the Direct Method (2003)

A recent stability analysis, the Direct Method, for linear time invariant, time delayed systems (LTI-TDS) is revisited in this work considering the degenerate system dynamics. The principal strengths and enabling novelties of the method are reviewed along with its structured steps involved for assessing the stability. Uncommon in the literature, the Direct Method can handle large dimensional systems (e.g., larger than two) very comfortably. It returns an explicit formula for the exact stability posture of the system for a given time delay, as such it reveals the possible detached stability pockets throughout the time delay axis. Both retarded and neutral classes of LTI-TDS are considered in this work. The main contribution here is to demonstrate the ability of the Direct Method in tackling degenerate cases. Along with the analytical arguments, example case studies are provided for a group of degeneracies. It is shown that the new method is capable of resolving them without any difficulty.
Generation of Antigen-Specific Suppressor Cells during Allergy Desensitization (1980)

We used a suppressor-cell assay to study a possible mechanism of allergy desensitization. Before specific immunotherapy, blood mononuclear cells from 20 patients with ragweed hayfever failed to exhibit suppressor activity in vitro after stimulation by ragweed antigen E. However, when the 10 patients with allergic rhinitis had been desensitized by injections of ragweed extract, their mononuclear cells specifically suppressed a ragweed proliferative response six and 12 months after desensitization was begun (31 per cent and 48 per cent suppression, respectively). Suppressor mononuclear cells were not detected in 10 control subjects of in 10 patients with ragweed hayfever who were not desensitized. When mononuclear cells taken from treated patients were passed over columns containing insolubilized histamine, antigen-specific suppressor cells that could be activated by ragweed antigen were depleted. These results indicate that antigen-specific suppressor cells, probably bearing histamine receptors, are generated during desensitization to allergy and may be partly responsible for the efficacy of this therapy.
Red cell zinc protoporphyrin and protoporphyrin by HPLC with fluorescence detection (1986)

A high performance liquid chromatographic (HPLC) method was developed for the determination of zinc protoporphyrin (ZnPP) and protoporphyrin (PP) in whole blood. After adding the blood to dilute acetic acid, ZnPP and PP were extracted with dimethyl sulfoxide-acetone containing mesoporphyrin as internal standard. Following evaporation of the acetone, the haemin-free extract was analysed by HPLC. ZnPP and PP were separated on a reversed-phase column and quantitated by measuring fluorescence peak areas. The extraction method is simple, and applicable to batch analysis, and the HPLC separation is rapid and repoducible. The coefficient of variation for ZnPP was 5.6% and 3.3% for total red cell porphyrin levels of 3.5 and 10.2 mumol per litre RBC respectively. Results are discussed in patients with erythrohepatic protoporphyria, lead exposure, iron-deficiency and nonspecifically elevated total red cell porphyrins.
Impingement mixing in reaction injection molding (1980)

Abstract Impingement mixing is the unique feature of the reaction injection molding (RIM) process but mixheads are largely designed by trial and error. To visualize the impingement process we have taken high speed photographs. To characterize mixing quality we have followed adiabatic temperature rise of mixtures, varying Reynolds number, mixhead geometry and the reaction rate. These results are examined in terms of a simplified model which includes both fluid mechanical and polymerization aspects of the problem.
Genetic variation for improving the salt tolerance of durum wheat (1999)

Durum wheat (AB genomes) is more salt-sensitive than bread wheat (ABD genomes), a feature that restricts its expansion into areas with sodic or saline soils. Salt tolerance in bread wheat is linked with a locus on the D genome that results in low Na+ uptake and enhanced K+/Na+ discrimination. In order to introduce salt tolerance into current durum wheats from sources other than the D genome, a search for genetic variation in salt tolerance was made across a wide range of tetraploids representing 5 Triticum turgidum sub-species ( durum , carthlicum , turgidum , turanicum , polonicum ). Selections were screened for low Na+ uptake and enhanced K+/Na+ discrimination. This was assessed in seedlings grown in 150 m? NaCl with supplemental Ca2+, by measuring the Na+ and K+ accumulated in the blade of a given leaf over 10 days. Large and repeatable genetic variation was found. Low Na+ accumulation and high K+/Na+ discrimination of similar magnitude to that of bread wheat was found in the sub-species durum . These selections have the potential for improving salt tolerance in durum wheat breeding programs.
Pre-operative simulation and post-operative validation of soft-tissue deformations for breast implantation planning (2006)

Virtual surgery simulation plays an increasingly important role as a planning aid for the surgeon. A reliable simulation method to predict the surgical outcome of breast reconstruction and breast augmentation procedures does not yet exist. However, a method to pre-operatively assess the result of the procedure would be useful to ensure a symmetrical and naturally looking result, and could be a practical means of communication with the patient. In this paper, we present a basic framework to simulate a subglandular breast implantation. First, we propose a method to build a model of the patient's anatomy, based on a 3D picture of the skin surface in combination with thickness estimates of the soft tissue surrounding the breast. This approach is cheap, fast and the picture can be taken while the patient is standing upright, which makes it advantageous compared to conventional CTor MR-based methods. Second, a set of boundary conditions is defined to mimic the effect of the implant. Finally, we compute the new equilibrium geometry using the iterative FEM-based Mass Tensor Method, which is computationally more effcient than the traditional FEM approach since sufficient precision can be achieved with a limited number of iterations. We illustrate our approach with a preliminary validation study on 4 patients. We obtain promising results with a mean error between the simulated and the true post-operative breast geometry below 4 mm and maximal error below 10 mm, which is found to be sufficiently accurate for visual assessment in clinical practice.
Kernel controllers: A systems-theoretic approach for data-driven modeling and control of spatiotemporally evolving processes (2015)

We consider the problem of modeling, estimating, and controlling the latent state of a spatiotemporally evolving continuous function using very few sensor measurements and actuator locations. Our solution to the problem consists of two parts: a predictive model of functional evolution, and feedback based estimator and controllers that can robustly recover the state of the model and drive it to a desired function. We show that layering a dynamical systems prior over temporal evolution of weights of a kernel model is a valid approach to spatiotemporal modeling that leads to systems theoretic, control-usable, predictive models. We provide sufficient conditions on the number of sensors and actuators required to guarantee observability and controllability. The approach is validated on a large real dataset, and in simulation for the control of spatiotemporally evolving function.
An efficient PEEC algorithm for modeling of LTCC RF circuits with finite metal strip thickness (2003)

In this letter, a simple but effective method is introduced to facilitate the partial element equivalent circuit (PEEC) algorithm to model multilayered low-temperature co-fired ceramics (LTCC) embedded RF circuits with finite metal thickness. The method makes use of the quasistatic assumption that charges only reside on the surfaces of a conductor. In the calculation of the coefficient of potential matrix, one thick conductor plate is treated as two inter-connected zero-thickness plates. Recombining the two plates analytically can correctly account for the increase of plate-to-plate capacitance without adding extra elements to the resultant equivalent circuit model. Experimental results have verified the validation of the proposed method.
HYPOTONIA ACCOMPANYING THE NEUROSURGICAL RELIEF OF ESSENTIAL TREMOR (1968)

BLACKER, H. MARTIN M.D.; BERTRAND, CLAUDE M.D.; MARTINEZ, NAPOLEON M.D.; HARDY, JULES M.D.; MOLINA-NEGRO, PEDRO M.D Author Information
Effects of dietary protein on whole-body protein turnover and endocrine function in young-adult and aging dogs. (2001)

Thirty-six adult female Beagles averaging 2 (young-adult) or 8 (geriatric) yr of age were used to assess the effects of graded levels of dietary protein (16, 24, or 32%) on endocrine-controlled regulation of whole-body protein turnover. Rates of whole-body protein synthesis (WBPS) and whole-body protein degradation (WBPD) were estimated using orally administered 15N-glycine and total excreta collection. Although N balance was similar for all dogs, N flux through the metabolic pool increased linearly (P < 0.05) as protein intake increased. Rates of WBPS, WBPD, or the difference between them were not influenced by age (P > 0.10). A quadratic increase (P < 0.05) in WBPS and WBPD was observed in response to dietary protein. Serum insulin-like growth factor-I (IGF-I), IGF-I-binding protein 3, and total IGF-I-binding proteins were higher (P < 0.05) in geriatric dogs than in young-adult dogs regardless of protein intake. These results indicate that dietary protein in excess of 16% may not be required to maintain N balance in young-adult and aging dogs despite the linear increase in N flux through the metabolic pool. Furthermore, age-induced changes in endocrine functionality may differ between dogs and other species.
FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells (1998)

TcRzeta/CD3 ligation initiates a signaling cascade involving CD4/CD8-p56(lck), p59(fyn), and ZAP-70, as well as lymphoid downstream proteins VAV, SLP-76, and FYB/SLAP. A current question concerns the nature of the downstream binding partner(s) of FYB in T cells. In this study, using a two-hybrid screen with FYB as bait, we have identified eight clones, four of which correspond to the recently published lymphoid protein SKAP55, and two which correspond to a related protein with some 44% homology to SKAP55 (termed SKAP55-related protein, SKAP55R). The SKAP55 clones showed only minor differences (two substitutions and one residue deletion) from SKAP55. SKAP55R has the same overall structure as SKAP55 except for the presence of a unique N terminus with a well-defined coiled-coil domain. Both SKAP55 and SKAP55R were found to bind FYB through their SH3 domains and to act as substrates for the FYN kinase in T cells. Furthermore, immunofluorescence confocal microscopy showed that FYB and SKAP55 colocalize in the perinuclear region of cells. SKAP55 also colocalizes with another FYB binding protein, SLP-76. Taken together, these observations demonstrate that FYB is part of an interactive matrix with SKAP55 and a SKAP55-related protein.