gebhart/patrepeval huggingface dataset:
Tissue-specific autoregulation of the LXRα gene facilitates induction of apoE in mouse adipose tissue (2004)

The functions of the liver X receptors (LXRs) are not well documented in adipose tissue. We demonstrate here that expression of the LXRalpha gene is highly induced in vivo and in vitro in mouse and human adipocytes in the presence of the synthetic LXR agonist T0901317. This autoregulation is caused by an identified LXR-responsive element motif in the mouse LXRalpha promoter, which is conserved in the human LXRalpha promoter. Using different LXR-deficient mice, we demonstrate that the basal expression level of LXRalpha is increased in LXRbeta(-/-) mice, whereas the basal expression level of LXRbeta is unchanged in LXRalpha(-/-) mice. The two LXRs can compensate for each other in mediating ligand-activated regulation of LXR target genes involved in lipid homeostasis in adipose tissue. Sterol regulatory element binding protein-1 (SREBP-1), ATP binding cassette transporter A1 (ABCA1), ABCG1, as well as apolipoprotein E (apoE) are induced in vivo by T0901317 in wild-type, LXRalpha(-/-) or LXRbeta(-/-) mice but not in LXRalpha(-/-)beta(-/-) mice. Although SREBP-1 and ABCG1 are induced in liver, muscle, and adipose tissue, the apoE, glucose transporter-4 (GLUT4), and LXRalpha genes are specifically induced only in adipose tissue. We suggest that an important aspect of LXRalpha autoregulation in adipose tissue may be to increase the level of LXRalpha over a threshold level necessary to induce the expression of certain target genes.
Nanodispersions (2015)

General introduction - Definition of nanodispersions (nanosuspensions, nanoemulsions, swollen micelles or microemulsions, liposomes and vesicles) and their size range. General description of their colloid stability. Main advantages of nanodispersions and their industrial applications. Preparation of nanosuspensions by top-up process - Nucleation and growth and control of particle size distribution. Factors determining the formation of narrow particle size distribution. Role of surfactants and polymers. Preparation of nano-polymer colloids (lattices) by emulsion and dispersion polymerization. Factors affects the stability of nanosuspensions. Preparation of nanosuspensions by bottom down process - Dispersion of preformed particles in liquids and the need of a wetting agent. Break-up of aggregates and agglomerates by application of high speed stirrers. Reduction of particle size by application of intense energy (microfluidization or bead milling). Maintenance of the colloid stability of the resulting particles. Reduction of Ostwald ripening. Industrial applications of nanosuspensions - Application in pharmacy to enhance bioavailability, Application in sunscreens for UV protection. Application in paints and coatings. Preparation of nanoemulsions by the use of high pressure homogenisers - Principles of emulsion formation and the role of the emulsifier. Selection of emulsifiers. Methods of emulsification and prevention of coalescence during emulsification. Origin of colloid stability of nanoemulsions. Prevention of Ostwald ripening Low energy methods for nanoemulsion preparation - The phase inversion composition method and the role of mixing the surfactant with oil and water. The phase inversion temperature method for preparation of nanoemulsions. Preparation of nanoemulsions by dilution of microemulsions. Practical examples of nanoemulsions and their industrial application - Nanoemulsions based on non-ionic surfactants and the role of the hydrophilic-lipophilic balance. Effect of oil solubility on the stabilityof nanoemulsions. Nanoemulsions based on polymeric surfactants. Applications in pharmacy and cosmetics. Swollen micelles or microemulsions Definition of microemulsions and their size range. Thermodynamic definition of microemulstions. Theories of microemulsion formation and stability. Characterisation of microemulsions using scattering, conductivity and NMR rechniques. Formulation of microemulsions and their industrial applications - Distinction between microemulsions and macroemulsions. Formulation of oil/water and water/oil microemulsions. Selection of emulsifiers for microemulsions. Application of microemulsions in tertiary oil recovery. Liposomes and vesicles - Formation of multilamellar lipid layers (liposomes) by dispersion of lipids in water. Formation of unilamellar vesicles by sonication of the liposomes. Factors responsible for stabilisation of liposomes and vesicles. Use of block copolymers to enhance the stability of vesicles. Applications of liposomes and vesicles in pharmacy and cosmetics.
The Kraft's Inequality of Scheduling for Packet-Switched Clos Networks (2008)

The traffic matrix decomposition provides an effective scheduling approach to guarantee capacity of services supported by input queued packet switches. The Birkhoff-von Neumann (BvN) decomposition is widely used to express the doubly stochastic rate matrix as a weighted sum of permutation matrices. The switch then schedules these permutation matrices, using weights corresponding to the coefficients in the decomposition. In a Clos network, each permutation matrix corresponds to a connection pattern in the middle stage. If we regard this set of predetermined connection patterns as a code book, scheduling incoming packets in the input buffer according to predetermined connection patterns is a process similar to the encoding of source signals. In light of the concerns on delay jitter, it is expected that the scheduling should be as smooth as possible. A measurement of smoothness is defined in terms of interstate time of the scheduled sequence. In this paper, we show that the smoothness of scheduling is bounded by the entropy of BvN decomposition, and satisfies the Kraft's inequality. The optimal scheduling can be achieved if and only if the Kraft's equality holds.
Elastic Fragments for Dense Scene Reconstruction (2013)

We present an approach to reconstruction of detailed scene geometry from range video. Range data produced by commodity handheld cameras suffers from high-frequency errors and low-frequency distortion. Our approach deals with both sources of error by reconstructing locally smooth scene fragments and letting these fragments deform in order to align to each other. We develop a volumetric registration formulation that leverages the smoothness of the deformation to make optimization practical for large scenes. Experimental results demonstrate that our approach substantially increases the fidelity of complex scene geometry reconstructed with commodity handheld cameras.
Recent and Planned Developments of the Program OxCal (2013)

OxCal is a widely used software package for the calibration of radiocarbon dates and the statistical analysis of 14 C and other chronological information. The program aims to make statistical methods easily available to researchers and students working in a range of different disciplines. This paper will look at the recent and planned developments of the package. The recent additions to the statistical methods are primarily aimed at providing more robust models, in particular through model averaging for deposition models and through different multiphase models. The paper will look at how these new models have been implemented and explore the implications for researchers who might benefit from their use. In addition, a new approach to the evaluation of marine reservoir offsets will be presented. As the quantity and complexity of chronological data increase, it is also important to have efficient methods for the visualization of such extensive data sets and methods for the presentation of spatial and geographical data embedded within planned future versions of OxCal will also be discussed.
Broadband THz Pulse Transmission Through the Atmosphere (2011)

We have transmitted a low-power beam of repetitive broadband THz pulses the record distance of 167 m through the atmosphere with 51% relative humidity at 21°C and have observed the broadened transmitted pulses with a signal to noise ratio greater than 200. The measured transmitted pulses reshaped from a 0.5-ps input pulse into an output pulse structure with a 5-ps symmetric pulse at the leading edge followed by a frequency-swept, rapidly oscillating trailing edge extending with increasing frequency to beyond 150 ps. The leading pulse appearing in the output pulse structure is composed of phase-locked frequency components extending from 0.07 to 0.37 THz that experienced negligible attenuation and group velocity dispersion due to transmission through water vapor. Such a stable pulse shape is suitable for the THz bit in a digital THz communications channel. Our results demonstrate a bit rate-distance product of greater than 8 (Gb/s)-km, which is comparable to an optical fiber digital communications channel.
Nondestructive characterization of materials in aging systems : symposium held November 30-December 4, 1997, Boston, Massachusetts, U.S.A. (1998)

Economics often dictate the use of structures well beyond their design lives. There is an increased reliance on nondestructive evaluation (NDE) to provide accurate data about the health of materials in these aging systems. Examples of such structures include aircraft, bridges, nuclear reactors, roads, ships, industrial manufacturing facilities, storage vessels for both toxic and nontoxic substances, electronic hardware, etc. This book looks at ways to develop new NDE techniques for aging materials. Special emphasis is given to the structural health of concrete, defects in high-strength aircraft materials and the characterization of steels in nuclear reactors. One intriguing new technology, borrowed from the semiconductor industry, is the use of very small micro-electro-mechanical systems (MEMS) to monitor materials properties in situ. Using these devices in networks should permit both real-time monitoring of materials properties during operation and the anticipation of component failure. The book also explores the many potentially fertile collaborative research opportunities between NDE and noninvasive medical diagnostic procedures.
Alterations of Lysine Modifications on the Histone H3 N-Tail under Drought Stress Conditions in Arabidopsis thaliana (2008)

Post-translational modification of histone N-tails affects eukaryotic gene activity. In Arabidopsis, the histone modification level correlates with gene activation and repression in vernalization and flowering processes, but there is little information on changes in histone modification status and nucleosome structure under abiotic stresses. We determined the temporal and spatial changes in nucleosome occupancy and levels of H3K4me3, H3K9ac, H3K14ac, H3K23ac and H3K27ac in the histone H3 N-tail on the regions of four Arabidopsis drought stress-inducible genes, RD29A, RD29B, RD20 and At2g20880 [corrected], under drought stress conditions by chromatin immunoprecipitation analysis. We found two types of regulatory mechanisms of nucleosome occupancy function in the drought stress response. For RD29A and RD29B genes, nucleosome occupancy of promoter regions is low compared with that of coding regions, and no notable nucleosome loss occurs under drought stress. In contrast, nucleosome density is gradually decreased in response to drought stress on RD20 and At2g20880 [corrected] genes. Enrichments of H3K4me3 and H3K9ac correlate with gene activation in response to drought stress in all four genes. Interestingly, establishment of H3K4me3 occurs after accumulation of RNAPII on the coding regions of RD29A and At2g20880 [corrected]. Enrichment of H3K23ac and H3K27ac occurs in response to drought stress on the coding regions of RD29B, RD20 and At2g20880 [corrected], but not on the coding region of At2g20880 [corrected]. Our results indicate that histone modifications on the H3 N-tail are altered with gene activation on the coding regions of drought stress-responsive genes under drought stress conditions and that several patterns of nucleosome changes function in the drought stress response.
Recombinant Human Interferon‐α2a Increases Hormone Receptor Level of a Human Breast Carcinoma Xenograft in Nude Mice and Enhances the Anti‐proliferative Activity of Tamoxifen (1992)

The effect of recombinant human interferon-alpha 2a (rhIFN-alpha 2a) on the hormone receptor level and antitumor activity of tamoxifen (TAM) was investigated in nude mice using ZR-75-1, an estrogen receptor (ER)-positive, and progesterone receptor (PgR)-negative human breast carcinoma xenograft. ER levels (maximum binding sites) of tumors treated with rhIFN-alpha 2a at a dose of 6 x 10(5) U/mouse/day for 1 or 3 wk were not significantly different from the control, whereas those with rhIFN-alpha 2a at a dose of 6 x 10(4) U/mouse/day for 1 or 3 wk were higher than the control (3.9- to 4.4-fold) with a significant difference at P < 0.01. The increase of ER by rhIFN-alpha 2a was investigated using a sucrose density gradient method. The peak was only seen at 8S in both rhIFN-alpha 2a-treated tumor and control ER, and the sedimentation patterns were almost the same, suggesting that both ERs were essentially equivalent. On the other hand, PgR of all the treated groups could be detected, while that of the control group was undetectable. The antitumor effect of the combination treatment of rhIFN-alpha 2a and TAM was compared with those of single treatments. While rhIFN-alpha 2a at a dose of 6 x 10(5) U/mouse/day and TAM did not show a combination effect, rhIFN-alpha 2a at a dose of 6 x 10(4) U/mouse/day and TAM showed a synergistic combination effect, and ER was decreased to the threshold of detection by the combination treatment. These findings indicated that a low dose of rhIFN-alpha 2a increased the ER levels of ER-positive human breast cancer in vivo as well as in vitro and enhanced the anti-proliferative effect of TAM, and the newly synthesized ER was essentially the same as the original ER.
Synthesis and Characterization of Branched‐Chain Derivatives of Methyl Oleate (2008)

Abstract Oleic acid is one of the most abundant fatty acid components of the triglycerides in many vegetable oils, such as cottonseed oil. As part of a project to develop new and expanded uses of oilseed products and by‐products (such as biodiesel, fuel additives, and lubricants), studies were conducted on the synthetic conversion of oleic acid (in ester form) to branched‐chain fatty acid esters. In these studies, methyl oleate was brominated in the allylic position and subsequently treated with organocuprate reagents to produce novel branched‐chain derivatives (ethyl, n ‐butyl, n ‐hexyl, phenyl). Details of the syntheses, characterization (GC/MS and NMR), and the properties of the products (with emphasis on low‐temperature properties) are discussed. Several of the synthesized products exhibited significantly lower re‐crystallization temperatures in comparison with methyl oleate and may prove useful as additives to biodiesel for use at low temperatures.
Computing exact automaton representations for a class of hybrid systems (2002)

It is known that one can not always have a finite state representation for hybrid systems and many decision properties can be undecidable. It was shown in Cury et al. (1995), however, that if one has a finite state automaton that generates an outer approximation to the hybrid system language, it may be possible to synthesize a discrete-state supervisor to control the hybrid system based on the approximating automaton using standard synthesis methods from the theory of discrete event systems (DESs). In this paper we develop conditions under which the automaton generated by a modification of the approximation algorithm from Niinomi et al. (1996) generates the exact language for the hybrid system.
A histone-like protein (HTa) from Thermoplasma acidophilum. I. Purification and properties. (1981)

A histone-like protein (HTa) has been isolated from cell extracts of Thermoplasma acidophilum by column chromatography on DNA-cellulose, hydroxylapatite, and Sephadex G-75, HTa elutes from DNA-cellulose in two fractions, one of which contains an 80-residue form of the protein with an NH2-terminal sequence of Val-Gly. The other fraction apparently contains the 89-residue species, in addition to a 90-residue form of the protein with the NH2-terminal sequence Met-Val. The sequence of 47 residues from the NH2 terminus of the 89-residue protein was established by automated Edman degradation. HTa is characterized by the following properties: 22% of its residues are lysine and arginine; the lysine:arginine ratio is 2.33; the absorption spectrum of the protein is distinctive due to the lack of tryptophan and the presence of 1 tyrosine and 5 phenylalanine residues; and the protein stabilizes DNA against thermal denaturation (Stein, D. B., and Searcy, D. G. (1978) Science 202, 219-221) and condenses DNA into spherical particles. All of these characteristics indicate that HTa resembles eukaryotic histones, but there are distinctive differences.
Nonlinear Impairment Compensation Using Backpropagation (2009)

TechniqueThis procedure must meet the following stages:  Pictures with frontal and tangential light.(Fig. 2)  Marking the skin with the patient standing. Tumescent Anesthesia. Creation of receptor tunnels in the depressed zones (receptors). Preparation of adipose tissue micrografts with MGFC in the donor area. Mobilizing micrografts. Tunneling  Stabilization of mobilized tissue.(Microporing and Reston foam for fixing)
Technology Reliability Qualification of a 65nm CMOS Cu/Low-k BEOL Interconnect (2006)

During the development and qualification of a 300mm low-k/Cu back end of line (BEOL) technology, the long-term reliability of such interconnects including low-k time-dependent dielectric breakdown (TDDB), Cu electromigration (EM), Cu stress migration (SM), and Cu/low-k thermal behavior are rapidly becoming one of the most critical challenges. In this paper, a comprehensive reliability evaluation for 65nm Cu/low-k interconnects is reported and various reliability issues associated with process integration and material optimization during initial development stage are discussed. Finally, we demonstrate that with careful process and materials optimization, a superior interconnect reliability performance at the 65nm technology node can be achieved for 300mm fabrication. The projected reliability lifetimes of TDDB, EM, and SM meet the most stringent reliability targets and criteria
VLSI architectures for the full-search blockmatching algorithm (2003)

Systolic VLSI architectures for an implementation of the full-search block-matching algorithm are described. A large range of data rates can be efficiently covered by the proposed architectures. The input bandwidth problem for the search-area data is solved with on-chip line buffers. Two data input modes are investigated: line-scan mode and block-scan mode. A VLSI realization with a very low transistor count and a small chip area can be achieved by linear arrays in conjunction with compact memory blocks based on three-transistor cells.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Strongly Typed Genetic Programming (1995)

Genetic programming is a powerful method for automatically generating computer programs via the process of natural selection (Koza, 1992). However, in its standard form, there is no way to restrict the programs it generates to those where the functions operate on appropriate data types. In the case when the programs manipulate multiple data types and contain functions designed to operate on particular data types, this can lead to unnecessarily large search times and/or unnecessarily poor generalization performance. Strongly typed genetic programming (STGP) is an enhanced version of genetic programming that enforces data-type constraints and whose use of generic functions and generic data types makes it more powerful than other approaches to type-constraint enforcement. After describing its operation, we illustrate its use on problems in two domains, matrix/vector manipulation and list manipulation, which require its generality. The examples are (1) the multidimensional least-squares regression problem, (2) the multidimensional Kalman filter, (3) the list manipulation function NTH, and (4) the list manipulation function MAPCAR.
Molecular sieves for gas separation (2016)

Metal-organic framework materials enable efficient separation of similar gases
Pulmonary dirofilariasis: first reported case in Puerto Rico. (1995)

The first case of human pulmonary dirofilariasis in our country is reported. The etiopathogenesis and pathological findings of the zoonosis are discussed.
Characterization of Hemoglobin Variants by MALDI-TOF MS Using a Polyurethane Membrane as the Sample Support (1998)

A new method for the sampling and off-site analysis of hemoglobin variants by mass spectrometry is reported. This technique uses a nonporous polyurethane membrane as the collection device and transportation medium of a blood sample for analysis. The same membrane is then used as the MALDI-TOF MS sample support for mass spectrometric analysis. Minimal invasive sample collection is afforded by collecting less than 1 microL of blood using a common lancet device. MALDI-TOF MS is performed directly on the membrane, after washing off the interfering plasma components, followed by the addition of matrix. This reduces the time of analysis and prevents sample loss. Enzymatic digestion can be performed directly on the membrane, using in this case trypsin, allowing for further characterization of the sample. The method is much less invasive compared to drawing blood with a syringe. The sample may be transported to the laboratory by regular mail, and thus the method can serve remote locations. We demonstrate the procedure by characterizing the Hb Shepherds Bush hemoglobin variant, b74-(E18)Gly-->Asp.
A herpes simplex virus 1 US11-expressing cell line is resistant to herpes simplex virus infection at a step in viral entry mediated by glycoprotein D (1994)

A baby hamster kidney [BHK(tk-)] cell line (US11cl19) which stably expresses the US11 and alpha 4 genes of herpes simplex virus 1 strain F [HSV-1(F)] was found to be resistant to infection with HSV-1. Although wild-type HSV-1(F) attached with normal kinetics to the surface of US11cl19 cells, most cells showed no evidence of infection and failed to accumulate detectable amounts of alpha mRNAs. The relationship between the expression of UL11 and resistance to HSV infection in US11cl19 cells has not been defined, but the block to infection with wild-type HSV-1 was overcome by exposing cells with attached virus on their surface to the fusogen polyethylene glycol, suggesting that the block to infection preceded the fusion of viral and cellular membranes. An escape mutant of HSV-1(F), designated R5000, that forms plaques on US11cl19 cells was selected. This mutant was found to contain a mutation in the glycoprotein D (gD) coding sequence that results in the substitution of the serine at position 140 in the mature protein to asparagine. A recombinant virus, designated R5001, was constructed in which the wild-type gD gene was replaced with the R5000 gD gene. The recombinant formed plaques on US11cl19 cells with an efficiency comparable to that of the escape mutant R5000, suggesting that the mutation in gD determines the ability of the mutant R5000 to grow on US11cl19 cells. The observation that the US11cl19 cells were slightly more resistant to fusion by polyethylene glycol than parental BHK(tk-) cells led to the selection and testing of clonal lines from unselected and polyethylene glycol-selected BHK(tk-) cells. The results were that 16% of unselected to as much as 36% of the clones selected for relative resistance to polyethylene glycol fusion exhibited various degrees of resistance to infection. The exact step at which the infection was blocked is not known, but the results illustrate the ease of selection of cell clones with one or more sites at which infection could be blocked.