gebhart/patrepeval huggingface dataset:
Sperm Protein 17: Clinical Relevance of a Cancer/Testis Antigen, from Contraception to Cancer Immunotherapy, and Beyond (2011)

Sperm protein 17 belongs to the cancer/testis antigen family and was found to play a key role in the cell fusion process between the mammalian spermatozoa and egg. Sperm protein 17-specific autoantibodies in vasectomized males suggest its high expression in the testis. Sperm protein 17 expression levels are low or absent in normal tissues, other than the testis. Sperm protein 17 is expressed by tumors, including ovarian cancer, indicating that it is an ideal target for cancer immunotherapy, and plays a role in tumorigenesis and drug resistance. This review recapitulates the milestones of sperm protein 17 research and highlights its potential use in translational medicine.
From β‐glucanase to β‐glucansynthase: glycosyl transfer to α‐glycosyl fluorides catalyzed by a mutant endoglucanase lacking its catalytic nucleophile (1998)

Removal of the catalytic nucleophile Glu134 of the retaining 1,3-1,4-beta-glucanase from Bacillus licheniformis by mutation to alanine yields an enzyme with no glycosidase activity. The mutant is able to catalyze the regio- and stereospecific glycosylation of alpha-laminaribiosyl fluoride with different glucoside acceptors through a single-step inverting mechanism. The main advantage of the mutant as glycosylation catalyst with respect to the kinetically controlled transglycosylation using the wild-type enzyme is that the reaction products cannot be hydrolyzed by the mutant enzyme, and glycosylation yields rise to 90%.
Metal‐Free Dehydration of Glucose to 5‐(Hydroxymethyl)furfural in Ionic Liquids with Boric Acid as a Promoter (2011)

The dehydration of glucose and other hexose carbohydrates to 5-(hydroxymethyl)furfural (HMF) was investigated in imidazolium-based ionic liquids with boric acid as a promoter. A yield of up to 42% from glucose and as much as 66% from sucrose was obtained. The yield of HMF decreased as the concentration of boric acid exceeded one equivalent, most likely as a consequence of stronger fructose-borate chelate complexes being formed. Computational modeling with DFT calculations confirmed that the formation of 1:1 glucose-borate complexes facilitated the conversion pathway from glucose to fructose. Deuterium-labeling studies elucidated that the isomerization proceeded via an ene-diol mechanism, which is different to that of the enzyme-catalyzed isomerization of glucose to fructose. The introduced non-metal system containing boric acid provides a new direction in the search for catalyst systems allowing efficient HMF formation from biorenewable sources.
[Laparoscopic surgery in adhesive disease]. (2004)

Experience in 2277 laparoscopic surgeries performed in patients with history of conventional and minimally invasive surgeries is analyzed. Regularities of commissures formation after some surgeries are determined. Viscero-parietal commissures (VPC) which are the main cause of possible intraoperative complications were revealed in 1746 (76,7%) patients. Diagnostic value of special ultrasonic examination was 95,5%, on the average. Laparoscopic adhesiolysis in different types of adhesive disease was attempted in 195 patients, 170 (87,2%) procedures were finished successfully. Application of Interceed (TC-7) on parietal peritoneum was used in 14 patients to prevent repeated formation of commissures.
A guidance algorithm for launch to equatorial orbit (2009)

Purpose The purpose of this paper is to propose a new guidance algorithm for launching a satellite using an expendable rocket from an equatorial site to an equatorial low‐Earth orbit. Design/methodology/approach Guidance during endoatmospheric portion is based on a nominal trajectory computed prior to take‐off. A set of updating computations begins anew at the time instant t g of transition from endoatmosphere to exoatmosphere. The updating computations determine a guidance trajectory and an associated control law for the remainder of path by taking into account the rocket state at time t g . Thus, the overall guidance involves both initial and midcourse operations, and it has both open‐ and closed‐loop aspects. Findings Viability and performance in terms of speed, precision, and effectiveness of the proposed scheme is demonstrated through three‐dimensional simulations and comparisons to other methods. Originality/value The updating computations and the fashion in which they are incorporated into the entire guidance process constitute the novel features of the proposed algorithm.
High Intestinal and Systemic Levels of Interleukin-23/T-Helper 17 Pathway in Chinese Patients with Inflammatory Bowel Disease (2013)

Interleukin-23/T-helper 17 (IL-23/Th17) pathway plays a key role in the pathogenesis of inflammatory bowel disease (IBD), but little is known about its expression in Chinese population. In this study, we investigated the mRNA and protein levels of IL-12p40, tumor necrosis factor-like cytokine 1A (TL1A), Janus kinase 2 (JAK2), and IL-23R both locally and systemically in Chinese IBD patients. Our results indicated that the mRNA levels of IL-12p40 and TL1A were increased in ulcerative colitis (UC) patients. Furthermore, serum IL-12p40 and TL1A levels were higher in active UC patients, especially in patients with disease course less than 1.25 years or initial onset. No correlation was found between the genotype and serum levels of IL-12p40 or TL1A in UC patients. Additionally, the mRNA and protein expression of JAK2 and IL-23R were increased in UC and Crohn's disease (CD) patients. Taken together, our results provided evidence that IL-23/Th17 pathway genes may represent important biomarkers of active stage of IBD and serve as novel therapeutic targets for IBD in Chinese population.
Signal Stabilization of a Control System (1957)

Abstract Linear automatically controlled systems with two or more dominant lags may be stabilized by the introduction of noise, or a signal of sufficiently high frequency, or a signal with sufficiently high-frequency components, provided that the hunt of the system is not excessively severe. The amplitude of the signal must be enough to run a bounded element, such as a governor pilot valve, through its full stroke. One or multiple-lag systems with optimum nonlinear controls also may be stabilized by an appropriate signal. Unless the stabilizing signal is great the response to the larger disturbances will be affected negligibly.
Active messages (1992)

The design challenge for large-scale multiprocessors is (1) to minimize communication overhead, (2) allow communication to overlap computation, and (3) coordinate the two without sacrificing processor cost/performance. We show that existing message passing multiprocessors have unnecessarily high communication costs. Research prototypes of message driven machines demonstrate low communication overhead, but poor processor cost/performance. We introduce a simple communication mechanism, Active Messages , show that it is intrinsic to both architectures, allows cost effective use of the hardware, and offers tremendous flexibility. Implementations on nCUBE/2 and CM-5 are described and evaluated using a split-phase shared-memory extension to C, Split -C. We further show that active messages are sufficient to implement the dynamically scheduled languages for which message driven machines were designed. With this mechanism, latency tolerance becomes a programming/compiling concern. Hardware support for active messages is desirable and we outline a range of enhancements to mainstream processors.
Coexistence mechanism based on adaptive frequency hopping for interference-limited WPAN applications (2003)

In this paper, we present an adaptive hopping algorithm for a wireless personal area network (WPAN) receiver applying a frequency hopping. Analytical results based on the closed-form solutions for the aggregate throughput show that the proposed hopping algorithm using two denned hopping criteria is more effective method for the all kinds of interferers and gives an enhanced throughput with a moderate computational complexity.
Multidimensional chromatography using on-line coupled microcolumn liquid chromatography and capillary gas chromatography (1990)

Multidimensional chromatography using on-line coupled microcolumn liquid chromatography and capillary gas chromatography
Increased Myocyte Content and Mechanical Function Within a Tissue-Engineered Myocardial Patch Following Implantation (2009)

During the past few years, studies involving the implantation of stem cells, chemical factors, and scaffolds have demonstrated the ability to augment the mammalian heart's native regenerative capacity. Scaffolds comprised of extracellular matrix (ECM) have been used to repair myocardial defects. These scaffolds become populated with myocytes and provide regional contractile function, but quantification of the myocyte population has not yet been conducted. The purpose of this study was to quantitate the myocyte content within the ECM bioscaffold and to correlate this cell population with the regional mechanical function over time. Xenogenic ECM scaffolds derived from porcine urinary bladder were implanted into a full-thickness, surgically induced, right ventricular-free wall defect in a dog model. Zero, 2, and 8 weeks following implantation, regional function and myocyte content were determined in each patch region. Regional function did not significantly increase from 0 to 2 weeks. At 8 weeks, however, regional stroke work increased to 3.7 +/- 0.7% and systolic contraction increased to 4.4 +/- 1.2%. The myocyte content also significantly increased during that period generating a linear relationship between regional function and myocyte content. In conclusion, ECM used as a myocardial patch increases both the regional function and the myocyte content over time. The mechanical function generated in the patch region is correlated with the quantity of local tissue myocytes.
SOME ASPECTS OF TWO STAGE DIFFUSION IN POLYMER FILMS AND MEMBRANES (2012)

The two-stage sorption data for dichloromethane vapour in a cellulose triacetate films and membranes are analysed by the variable-surface concentration model and the diffusion relaxation model.Satisfactory fitting of the data and similar kinetic parameters are obtained using these models.The diffusion coefficient for dichloromethane is about 2.5 x 10 -11 m 2 s -1 in the glassy polymer at 40°C and is near 1.5 -2.5 times higher as the polymer goes over the glass-rubber transition region due to solvent sorption.The relaxation rate constant is between 3.0 and 18 x 10 -4 s -1 and is increased as the sorbed concentration or the vapour activity of solvent increases.When the two-stage non-Fick sorption prevails, the diffusion-relaxation model approximates the limiting cases of the both models.
Research on Scheduling Strategy of AFDX End System Based on Time/Event Trigger (2018)

To meet different time delay requirements of different data, three scheduling strategies based on event, time and event-time are studied in this paper. The network calculus method is used to derive the maximum delay upper bound of virtual link based on three scheduling strategies, the relationship between the maximum delay upper, virtual link parameters, time scheduleparameters and the frame length is compared, the difference between the alternate scheduling strategy and the Time-Triggered or event-triggered scheduling is studied. The AFDX (Avionics Full-Duplex Switched Ethernet) virtual network model is established toverifythetheory based on OPNET, thedeterminist of theTime-Triggered link, the maximum delay of the event-triggered link and the efficiency of the end system transmission are compared under different scheduling strategies. Also, the applicable occasions of different scheduling strategies are studied. The results show that the event and time alternate scheduling strategy not only ensures the certainty of Time-Triggered link transmission, but also reduces the event triggering. The maximum delay upper bound of the link effectively improves the data processing capability and transmission efficiency, ensures the stability and certainty of the periodic signal transmission, and is suitable for the aviation bus system with different kinds of data with different delay requirements.
Design of a Thermocontrollable Protein Complex (2007)

It is widely recognized that stimuli-responsive nanostructures play a promising role in nanodevices for medical treatments and experimental tools. We have designed and constructed a basic structure which controls the distance between two termini domains through temperature reversibility. Our structure, shaped like a bouquet, is composed of two proteins, alpha-helix and elastin-like protein (ELP). Alpha-helices align and bundle the ELP while ELP twists and forms a fiber-like structure at warm temperatures. This ELP conformational change alters the distance between the structure termini at the site opposite the alpha-helix. We connected enhanced yellow fluorescent protein (EYFP) and enhanced cyan fluorescent protein (ECFP) at the structure's two termini to evaluate the distance using fluorescence resonance energy transfer (FRET) efficiency. These proteins spontaneously formed a complex which decreased the distance between the two fluorescent proteins located at its termini, at physiologically relevant temperatures. This change was repeated with complete reversibility (n = 5).
Nonparametric rank-order statistics applied to robust voiced-unvoiced-silence classification (1980)

This paper describes a theoretical and experimental investigation for detecting the presence of speech in wide-band noise. A robust algorithm for making the voiced-unvoiced-silence decision is described. This algorithm is based on a nonparametric rank-order statistical signal-detection scheme that does not require a training set of data and maintains a constant false alarm rate for a broad class of noise inputs. Two rank-order decision procedures are investigated, the Kruskal-Wallis and the multiple use of the two-sample savage statistic. The performances of these detectors are evaluated and compared to that obtained from manually classifying twenty recorded utterances. In limited testing, the average probability of misclassification of voiced speech for the Savage case was less than 6, 13, 28, and 55 percent, corresponding to signal-to-noise ratios of 30, 20, 10, and 0 dB, respectively.
Description of stress–strain curves for stainless steel alloys (2015)

There is a wide variety of stainless steel alloys, but all are characterized by a rounded stress–strain response with no sharply defined yield point. This behaviour can be represented analytically by different material models, the most popular of which are based on the Ramberg–Osgood formulations or extensions thereof. The degree of roundedness, the level of strain hardening, the strain at ultimate stress and the ductility at fracture of the material all vary between grades, and need to be suitably captured for an accurate representation of the material to be achieved. The aim of the present study is to provide values and predictive expressions for the key parameters in existing stainless steel material models based on the analysis of a comprehensive experimental database. The database comprises experimental stress–strain curves collected from the literature, supplemented by some tensile tests on austenitic, ferritic and duplex stainless steel coupons conducted herein. It covers a range of stainless steel alloys, annealed and cold-worked material, and data from the rolling and transverse directions. In total, more than 600 measured stress–strain curves have been collected from 15 international research groups. Each curve from the database has been analysed in order to obtain the key material parameters through a curve fitting process based on least squares adjustment techniques. These parameter values have been compared to those calculated from existing predictive models, the accuracy of which could therefore be evaluated. Revised expressions providing more accurate parameter predictions have been proposed where necessary. Finally, a second set of results, containing material parameters reported directly by others, with information of more than 400 specimens, has also been collected from the literature. Although these experimental results were not accessible as measured raw data, they enabled further confirmation of the suitability of the proposed equations.
Protection of the Carbonyl Group as 1,2,4-Trioxane and Its Regeneration under Basic Conditions<sup>1</sup> (2005)

[chemical reaction: see text]. An experimental protocol demonstrating the protection of the carbonyl group as 1,2,4-trioxane, the stability of the protecting group under a variety of reaction conditions, and the regeneration of the carbonyl group with Triton B in THF at room temperature is presented. The method provides a useful alternative for the protection of carbonyl compounds having acid-sensitive moieties.
Evolutionary Aspects of Diet (2001)

The interaction of genetics and environment, nature, and nurture is the foundation for all health and disease. This concept, based on molecular biology and genetics, was originally defined by Hippocrates. In the 5th century bc, Hippocrates stated the concept of positive health as follows: 
Positive health requires a knowledge of man’s primary constitution [which today we call genetics] and of the powers of various foods, both those natural to them and those resulting from human skill [today’s processed food]. But eating alone is not enough for health. There must also be exercise, of which the effects must likewise be known. The combination of these two things makes regimen, when proper attention is given to the season of the year, the changes of the winds, the age of the individual and the situation of his home. If there is any deficiency in food or exercise the body will fall sick.
Intracranial therapy of glioblastoma with the fusion protein DTAT in immunodeficient mice (2006)

A gene splicing technique was used to create a hybrid fusion protein DTAT encoding the 390 amino acid portion of diphtheria toxin (DT(390)), a linker, and the downstream 135-amino terminal fragment portion of human urokinase plasminogen activator. DTAT was assembled to target human glioblastoma cell lines in a murine intracranial model. Previously published in vitro studies demonstrated that DTAT was highly selective and toxic to human glioblastoma cell lines in a flank tumor model. The purpose of this study was to determine the toxicity, specificity and possible therapeutic efficacy of DTAT in an intracranial model. Convection enhanced delivery of DTAT resulted in about a 16-fold increase in maximum tolerated dose. Intracranial administration of DTAT on an every-other-day basis in nude mice with established U87 MG brain tumors resulted in significant reductions in tumor volume and significantly prolonged survival (p < 0.0001). Magnetic resonance imaging proved to be a powerful tool in mice and rats for demonstrating tumor growth in a xenograft intracranial model, assessing the efficacy of DTAT in tumor volume reduction and detecting DTAT-associated intracranial toxicity and vascular damage. These results suggest that the DTAT recombinant fusion protein is highly effective in an intracranial model and DTAT might be an effective treatment for glioblastoma.
Siliceous Phytogenic Particles in Volcanic Ash (1963)

A great many examples of soils have been known to contain siliceous phytogenic particles called, also, plant opal, grass opal, phytolith, etc., which are originated from siliceous fillings of cells in plant grasses. The contents of the siliceous phytogenic particles in soils are in the positive relation to the humus contents.The same siliceous particles as in soils are also found in the various Quaternary volcanic ash deposits in which zones of buried soils (dark zones or cracky zones) are more abundant in the siliceous particles.The siliceous phytogenic particles are low (2.10-2.15) in specific density, very low (1.44-1.45) in refractive index, and are optically isotropic. They reveal only very broad diffraction near 4Å in X-ray diffraction diagram. Silica is predominant component of them. All above characteristics prove the particles to be opal. The sizes and shapes of the siliceous phytogenic particles seem to be controlled by the cells wherin they deposited. Thus, the fan-shaped ones are about 0.04mm. large, the rod-shaped ones are 0.02mm. wide with maximum length of 0.5mm., and the dumbell-shared ones are about 0.01mm. large (Fig. 1).The rather common occurrence of the siliceous phytogenic particles in the Quaternary volcanic ash deposits calls our attention in the following two aspects.First, the siliceous phytogenic particle is a possible indicator of a buried soil in the volcanic ash deposits with supplemental field and in-door evidences such as content of organic matter, degree of weathering, etc. (Fig. 2).Second, they must suggest the presence of plant grasses which grew in situ on the subaerial ground where volcanic ash deposited. Although some promissing results are in hand, it is riserved for further precise study whether species or genus names of the plant grasses, otherwise only the family names can be identified by them.
Overcoming Shadows in 3-Source Photometric Stereo (2010)

Light occlusions are one of the most significant difficulties of photometric stereo methods. When three or more images are available without occlusion, the local surface orientation is overdetermined so that shape can be computed and the shadowed pixels can be discarded. In this paper, we look at the challenging case when only two images are available without occlusion, leading to a one degree of freedom ambiguity per pixel in the local orientation. We show that, in the presence of noise, integrability alone cannot resolve this ambiguity and reconstruct the geometry in the shadowed regions. As the problem is ill-posed in the presence of noise, we describe two regularization schemes that improve the numerical performance of the algorithm while preserving the data. Finally, the paper describes how this theory applies in the framework of color photometric stereo where one is restricted to only three images and light occlusions are common. Experiments on synthetic and real image sequences are presented.
Potash from Polyhalite Relation between calcinations conditions and extraction behavior (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticlePotash from Polyhalite Relation between calcinations conditions and extraction behaviorJ. M. Davidson, A. A. Berk, J. E. Conley, and Everett P. PartridgeCite this: Ind. Eng. Chem. 1937, 29, 4, 475–482Publication Date (Print):April 1, 1937Publication History Published online1 May 2002Published inissue 1 April 1937https://pubs.acs.org/doi/10.1021/ie50328a027https://doi.org/10.1021/ie50328a027research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts