gebhart/patrepeval huggingface dataset:
PANRETINAL PHOTOCOAGULATION AND RETINAL OXYGENATION (1982)

Panretinal photocoagulation destroys some of the photoreceptors and thereby reduces the oxygen consumption in the outer retina and allows more O2 to flow from the choroid to the inner retina. Measurements of the preretinal oxygen tension were made in rhesus monkeys that had portions of their retinas photocoagulated. With the animal breathing one atmosphere O2, the oxygen tension over photocoagulated areas of retina was significantly higher than the PO2 over normal, untreated areas of retina. It is proposed that the therapeutic effect of panretinal photocoagulation in diabetic retinopathy lies in the oxygenation of the inner retina from the choroid.
Identification of transcription factor binding sites from ChIP-seq data at high resolution (2013)

Supplementary data are available at Bioinformatics online.
Paroxetine for Primary Insomnia (1999)

Article AbstractLetter to the EditorSir: Primary insomnia is widely prevalent, resulting in considerable distress and impairment. A new drug that is not a controlled substance, is nonhabituating, and that does not leave the patient sedated during the day would be a welcome addition to the pharmacopoeia. I read with interest the article by Nowell et al., which reported an uncontrolled, open study of the treatment of primary insomnia with the selective serotonin reuptake inhibitor antidepressant paroxetine in 14 patients.
The sequences homologous to major interspersed repeats B1 and B2 of mouse genome are present in mRNA and small cytoplasmic poty(A)<sup>+</sup>RNA (1982)

Heavy nuclear RNA contains high amounts of transcripts from repetitive sequences B1 and B2. Cytoplasmic poly(A)+RNA and, particularly, polysomal poly(A)+RNA (mRNA) also include these sequences but in smaller amounts. The abundant 2 kb mRNA of mouse liver are found to have a B2 sequence. These sequences are also found in a new class of low-molecular-weight heterogeneous (200-400 nucleotide long) poly(A)+RNAs. These RNAs are located mostly in cytoplasm rather than in polysomes. The amount of small B2+ RNAs is noticeable larger than that of small B1+ RNAs. Tumour cells seem to contain more small B2 RNA than normal cells. The hybridization tests show that extended homology exists between the B1 sequence and 4.5S small nuclear RNA, which is predicted from comparison of their base sequences. Also, we have found homology between B1 and small cytoplasmic 7S RNA. Hybridization of B2 to sn or sc RNAs has not been observed, although the sequencing reveals partial homology between B2 and 4.5S sn RNAI /1/.
Road recognition using coarse-grained vehicular traces (2012)

With more and more vehicles equipped with GPS tracking devices, there is increasing interest in building and updating maps using vehicular GPS traces. Most existing approaches for building maps rely on position traces from highly accurate positioning devices, which are sampled at a high frequency, e.g., every second. Typically these traces are recorded by survey vehicles. Commodity GPS devices are much more widespread, but have lower accuracy. In addition, the sampling frequency is low (at around once per minute) in order to reduce communication cost. Building maps from coarse-grained vehicular GPS traces is challenging due to the inherent noise in commodity GPS devices and the shape complexity of urban roads. In this paper, we propose a novel algorithm for recognizing urban roads with coarsegrained GPS traces from probe vehicles moving in urban areas. The algorithm overcomes the challenges by pruning low quality GPS traces, clustering GPS traces by road segments, and applying shape-aware B-spline fitting. We have conducted empirical study with a real data set of GPS traces from 2,300 taxis in Shanghai, China. Evaluation results demonstrate that our algorithm provides wide coverage, a low rate of false positives, and high accuracy. When there are 2,000 taxis and the time window for trace collection is 1.5 hours, the coverage of arterial roads is 93% and the rate of false positives is 5%. The roads recognized by our algorithm are more accurate than the roads on OpenStreetMap, a popular map editing website using GPS traces and satellite imagery. © Copyright 2012 Hewlett-Packard Development Company, L.P.
Downregulation of GRP78 and XIAP is correlated with apoptosis during cerulein-induced acute pancreatitis in rats via regulation of caspase activation (2012)

Our aim in the present study was to investigate the potential roles of the 78-kDa glucose-regulated protein (GRP78) and the X-linked inhibitor of apoptosis protein (XIAP) in the regulation of apoptosis during cerulein-induced acute pancreatitis (CAP). A rat CAP model was induced by injection of cerulein (50 µg/kg), and the severity of CAP was estimated by measuring serum amylase and lipase, pancreatic edema and histological changes. Pancreatic acinar cell apoptosis was determined by terminal-deoxynucleotidyl-transferase-mediated dUTP nick-end labeling (TUNEL) assay, and the expression of GRP78, XIAP and the apoptotic genes caspase-3, -7 and -9 were determined by real‑time quantitative PCR and western blotting. After induction with cerulein, increased serum amylase and lipase, pancreatic edema, inflammation and apoptosis were observed in CAP rats. Furthermore, the mRNA and protein levels of GRP78 and XIAP were significantly downregulated in CAP rats, while the mRNA levels of caspase-3, -7 and -9, as well as the cell apoptotic index were markedly increased when compared with control rats (P<0.05). The expression of GRP78 and XIAP was negatively correlated with caspase expression in CAP (P<0.05). This study suggests that the downregulation of GRP78 and XIAP were correlated with apoptosis in pancreatic acinar cells, and that this may occur through the regulation of caspase activation during CAP.
A MEMS mirror driver ASIC for beam-steering in scanning MEMS-based LiDAR (2019)

In this paper, a MEMS mirror driver ASIC that operates a 1D MEMS mirror with accurate amplitude is presented. It provides a set of position signals, precisely aligned to the MEMS mirror that enables a beam forming and laser shooting scheduling for LiDAR (Light Detection and Ranging) applications. The proposed architecture exploits a capacitive sense method and integrated control loops to sense, actuate and control the movements of the MEMS mirror. The implemented mixed-signal ASIC is fabricated in 130 nm CMOS technology, and can attain an RMS pointing error of less than 4m°for any tested MEMS mirror amplitude.
Role of lnterleukin-8 Receptor in Skin (1994)

Interleukin-8 (IL-8) is a potent chemotactic and proinflammatory cytokine, produced in the skin by a variety of cells in response to inflammatory stimuli. Recent studies suggest that in addition to its potent actions on leukocytes, IL-8 exerts a direct influence on several functions of human epidermal cells such as chemotaxis, Candida albicans killing activity or proliferation. The effects of IL-8 are mediated by binding to two types of specific high-affinity receptors which contain seven transmembrane domains typical of guanine nucleotide binding protein (G protein)-coupled receptors. In the skin, a broad spectrum of cells such as neutrophils, T lymphocytes, mast cells, dermal macrophages, endothelial cells and keratinocytes possess binding sites for IL-8. Recently, increased expression of epidermal IL-8 receptors has been observed in psoriasis an inflammatory and hyperproliferative skin disease. Since the effects of IL-8 may be modulated at the receptor level, the pharmacological manipulation of the IL-8 receptor may prove an important target for the therapy of skin diseases with increased IL-8 levels.
Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C (2004)

Liver fibrosis is the main predictor of the progression of chronic hepatitis C, and its assessment by liver biopsy (LB) can help determine therapy. However, biopsy is an invasive procedure with several limitations. A new, noninvasive medical device based on transient elastography has been designed to measure liver stiffness. The aim of this study was to investigate the use of liver stiffness measurement (LSM) in the evaluation of liver fibrosis in patients with chronic hepatitis C. We prospectively enrolled 327 patients with chronic hepatitis C in a multicenter study. Patients underwent LB and LSM. METAVIR liver fibrosis stages were assessed on biopsy specimens by 2 pathologists. LSM was performed by transient elastography. Efficiency of LSM and optimal cutoff values for fibrosis stage assessment were determined by a receiver-operating characteristics (ROC) curve analysis and cross-validated by the jack-knife method. LSM was well correlated with fibrosis stage (Kendall correlation coefficient: 0.55; P < .0001). The areas under ROC curves were 0.79 (95% CI, 0.73-0.84) for F > or =2, 0.91 (0.87-0.96) for F > or =3, and 0.97 (0.93-1) for F=4; for larger biopsies, these values were, respectively, 0.81, 0.95, and 0.99. Optimal stiffness cutoff values of 8.7 and 14.5 kPa showed F > or =2 and F=4, respectively. In conclusion, noninvasive assessment of liver stiffness with transient elastography appears as a reliable tool to detect significant fibrosis or cirrhosis in patients with chronic hepatitis C.
A Software-defined SoC Memory Bus Bridge Architecture for Disaggregated Computing (2018)

Disaggregation and rack-scale systems have the potential of drastically decreasing TCO and increasing utilization of cloud datacenters, while maintaining performance. While the concept of organising resources in separate pools and interconnecting them together on demand is straightforward, its materialisation can be radically different in terms of performance and scale potential.
Fungal endophytes from Dioscorea zingiberensis rhizomes and their antibacterial activity (2007)

Endophytic fungi isolated from D. zingiberensis may be used as potential producers of antibacterial natural products.
ChemInform Abstract: “Synthetic Metals”: A Novel Role for Organic Polymers (Nobel Lecture). (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effect of Oxygen Breathing on Pacing-Induced Angina Pectoris and other Manifestations of Coronary Insufficiency (1972)

Eleven patients with arteriographically confirmed coronary artery disease and normal arterial oxygen saturation were studied. The angina threshold was determined first by successive elevation of heart rate at increments of 10 and 5 beats/min by right atrial pacing while the patients were breathing air via a close-fitting mask. The mask was then connected to an oxygen tank without the patient's knowledge. After 5 min of oxygen breathing, the heart rate was again raised to the previously determined threshold level. In nine of 11 patients angina did not recur. The absence of angina was associated with improvement in myocardial lactate extraction from -17 ± 15 to +18 ± 10% ( P < 0.025), in S-T abnormalities in six of seven patients, and in pulsus alternans in three of five patients. The pacing rate was then raised at increments of 5 beats/min until angina recurred. With oxygen breathing, angina developed at higher pacing rates (129 ± 7 beats/min with air and 137 ± 6 beats/min with oxygen, on the average; P < 0.005), at higher rate-pressure product (18.0 ± 0.8 and 19.5 ± 0.9 x 10 3 mm Hg/min, respectively; P < 0.01), and at higher left ventricular oxygen consumption (21.3 ± 1.1 and 24.6 ± 1.1 ml/min, respectively; P < 0.005). The results indicate that oxygen breathing permits the heart to do more work before coronary insufficiency develops.
Phantom experiments of axial strain measurements using multidimensional autocorrelation method, multidimensional Doppler method and direct strain measurement method (2009)

Various tissue displacement vector measurement methods have been proposed by us, i.e., the multidimensional cross-spectrum phase gradient method (MCSPGM), the multidimensional autocorrelation method (MAM) and the multidimensional Doppler method (MDM). In this paper, actual measurement results obtained by MAM and MDM are reported. Specifically, for a compressed agar-graphite phantom (infinitesimally compressed, ≈0.07%; largely compressed, ≈0.7%), the measurement results for axial strain using MAM and MDM are shown and compared with those using MCSPGM, the conventional one-dimensional (1D) AM and the direct strain measurement method based on 1D AM (DSMM). Although DSMM was also developed by us in 1993, the method and the actual measurement results have not been reported elsewhere. Because the multidimensional methods can provide more accurate axial displacement measurements in real time and enable displacement vector measurement, 1D AM and DSMM might now be ineffective for practical applications.
Kernel Null Space Methods for Novelty Detection (2013)

Detecting samples from previously unknown classes is a crucial task in object recognition, especially when dealing with real-world applications where the closed-world assumption does not hold. We present how to apply a null space method for novelty detection, which maps all training samples of one class to a single point. Beside the possibility of modeling a single class, we are able to treat multiple known classes jointly and to detect novelties for a set of classes with a single model. In contrast to modeling the support of each known class individually, our approach makes use of a projection in a joint subspace where training samples of all known classes have zero intra-class variance. This subspace is called the null space of the training data. To decide about novelty of a test sample, our null space approach allows for solely relying on a distance measure instead of performing density estimation directly. Therefore, we derive a simple yet powerful method for multi-class novelty detection, an important problem not studied sufficiently so far. Our novelty detection approach is assessed in comprehensive multi-class experiments using the publicly available datasets Caltech-256 and Image Net. The analysis reveals that our null space approach is perfectly suited for multi-class novelty detection since it outperforms all other methods.
A 16 Gb/s Adaptive Bandwidth On-Chip Bus Based on Hybrid Current/Voltage Mode Signaling (2006)

This paper describes an adaptive bandwidth bus (ABB) architecture based on hybrid current/voltage mode repeaters for long global RC interconnect static busses that achieves high-data rates while minimizing the static power dissipation associated with current-mode signaling. Attaining a maximum aggregate bandwidth of 16 Gb/s (i.e., 1 Gb/s per line) across lossy on-chip interconnects spanning 1.75 cm in length, the bus core fabricated in 0.35 /spl mu/m CMOS technology dissipates approximately 93 mW with a supply of 2.5 V and signal activity of 0.5, equivalent to 5.71 pJ/bit. Experimental results using a 16-bit reference bus design that can be externally programmed to operate in voltage, current or adaptive modes indicate a 50% reduction in power dissipation over current-mode (CM) sensing, and an improvement in interconnection delay and signaling bandwidth of 35%-70% and 66% over voltage-mode (VM) sensing, respectively.
MiR-128 Inhibits Tumor Growth and Angiogenesis by Targeting p70S6K1 (2012)

MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed that miR-128 expression levels were decreased in glioma, and identified p70S6K1 as a novel direct target of miR-128. Overexpression of miR-128 suppressed p70S6K1 and its downstream signaling molecules such as HIF-1 and VEGF expression, and attenuated cell proliferation, tumor growth and angiogenesis. Forced expression of p70S6K1 can partly rescue the inhibitory effect of miR-128 in the cells. Taken together, these findings will shed light to the role and mechanism of miR-128 in regulating glioma tumor angiogenesis via miR-128/p70S6K1 axis, and miR-128 may serve as a potential therapeutic target in glioma in the future.
Block sequential least squares decision feedback equalization algorithm with application to terrestrial HDTV transmission (1998)

Due to the very high symbol rate of terrestrial HDTV systems, up to now there exist no equalization solutions with sufficiently low hardware complexity and satisfactory performance for commercial applications. We present a block sequential least squares decision feedback equalization algorithm with application to over-the-air HDTV channels. The proposed adaptive algorithm is derived on the basis of minimization of the least squares criterion, thereby achieving faster convergent and tracking rate relative to the recommended LMS algorithm. Meanwhile, good numerical stability is guaranteed because it successfully eliminates time updates of the filtering coefficients, which is the main cause of instability of FTF-like algorithms. Also of great significance is its drastic reduction in computational complexity by means of block operation, taking advantage of the slowly time-varying nature of terrestrial broadcasting channels. Simulation results show that the equalizer achieves an almost 3.5 dB SNR improvement at a bit error rate of 3/spl times/10/sup -6/ without significant increase in computational complexity, as compared to the conventional LMS decision feedback equalizer (DFE) when applied to the equalization of over-the-air HDTV channels.
The emerging roles of CDK12 in tumorigenesis (2017)

Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and transcription. Since dysregulation of CDKs is a frequently occurring event driving tumorigenesis, CDKs have been tested extensively as targets for cancer therapy. Cyclin-dependent kinase 12 (CDK12) is a transcription-associated kinase which participates in various cellular processes, including DNA damage response, development and cellular differentiation, as well as splicing and pre-mRNA processing. CDK12 mutations and amplification have been recently reported in different types of malignancies, including loss-of-function mutations in high-grade serous ovarian carcinomas, and that has led to assumption that CDK12 is a tumor suppressor. On the contrary, CDK12 overexpression in other tumors suggests the possibility that CDK12 has oncogenic properties, similarly to other transcription-associated kinases. In this review, we discuss current knowledge concerning the role of CDK12 in ovarian and breast tumorigenesis and the potential for chemical inhibitors of CDK12 in future cancer treatment.
The construction and characterization of Neisseria gonorrhoeae lacking protein III in its outer membrane. (1989)

Protein III (PIII) is a highly conserved, antigenically stable gonococcal outer membrane protein that is closely associated with the major outer membrane protein, protein I (PI). We have previously reported the cloning of the PIII gene. This gene was inserted into the Eco RI site of the runaway plasmid pMOB45. The beta-lactamase (beta la) Bam HI restriction fragment from the gonococcal plasmid pFA3 was inserted at the Xba I site in the PIII gene. The plasmid construct was Hae III methylated and the PIII/beta la insert was excised with Eco RI and used to transform gonococcal strain F62. One beta la+, ampicillin-resistant transformant was isolated and designated 2D. A Western blot of 2D whole cell lysate was probed with affinity-purified polyclonal PIII antisera. No PIII reactivity was detected. Southern blot analysis was performed on F62 and 2D chromosomal DNA that were cut with Eco RI or Cla I. A PIII DNA probe hybridized with fragments 2.2 kb larger in strain 2D than strain F62. This corresponds to the size of the beta la insert. A beta la-specific probe hybridized with the same 2D restriction fragments as above, but did not react with any F62 fragments, confirming that homologous recombination had occurred. There were minimal phenotypic changes between 2D and its parent strain, F62. Chromosomal DNA from 2D was able to transform gonococcal strains F62, UU1, and Pgh 3-2, rendering these PIII-. 2D and other PIII- transformants can now be used to study the role of PIII in gonococcal physiology, metabolism, membrane structure, and pathogenesis. Moreover, we now have organisms from which we can purify gonococcal proteins without PIII contamination.
Wood and cellulosic chemistry (1992)

Ultrastructure and formation of wood cell wall chemical composition and distribution structure of cellulose - recent developments in its characterization chemistry of lignin chemistry of cell wall polysaccharides chemistry of extractives chemistry of bark chemical characterization of wood and its components colour and discoloration chemical degradation weathering and photochemistry of wood microbial, enzymatic and biomimetric degradation of lignin in relation to bioremediation chemical modification of wood chemical modification of cellulose chemical synthesis of cellulose wood plasticization wood-polymer composites adhesion and adhesives pressure-sensitive adhesives and forest products wood-inorganic composites as prepared by the sol-gel process preservation of wood conservation of waterlogged wood biodegradable plastics from lignocellulosics recycling of wood and fibre products pulping chemistry.
MFC/NFC-Based Foam/Aerogel for Production of Porous Materials: Preparation, Properties and Applications (2020)

Nanofibrillated cellulose and microfibrillated cellulose are potential raw materials separated from plant fibers with a high aspect ratio and excellent mechanical properties, which can be applied in various fields (packaging, medicine, etc.). They have unique advantages in the preparation of aerogels and foams, and have attracted widespread attention in recent years. Cellulose-based porous materials have good biodegradability and biocompatibility, while high porosity and high specific surface area endow them with strong mechanical properties and liquid retention performance, which can be used in wall construction, sewage treatment and other fields. At present, the preparation method of this material has been widely reported, however, due to various process problems, the actual production has not been realized. In this paper, we summarize the existing technical problems and main solutions; in the meantime, two stable systems and several drying processes are described, and the application potential of cellulose-based porous materials in the future is described, which provides a reference for subsequent research.
Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial (2015)

The National Institute for Health Research through the UK National Cancer Research Network, the Medical Research Council, and Roche.