gebhart/patrepeval huggingface dataset:
Novel Role for PDEF in Epithelial Cell Migration and Invasion (2005)

Cell migration and invasion are two critical cellular processes that are often deregulated during tumorigenesis. To identify factors that contribute to oncogenic progression by stimulating cell migration, we conducted a powerful retroviral based migration screen using an MCF7 cDNA library and the immortalized human breast epithelial cell line MCF-10A. We identified prostate derived Ets factor (PDEF), an Ets transcription factor that is overexpressed in both prostate and breast carcinoma, as a candidate promigratory gene from this screen. Whereas PDEF induced limited motility of MCF-10A cells, coexpression of PDEF with the receptor tyrosine kinases (RTK) ErbB2 and colony-stimulating factor receptor (CSF-1R)/CSF-1 significantly enhanced MCF-10A motility. Furthermore, cells coexpressing PDEF with either ErbB2 or CSF-1R/CSF-1 induced a dramatic invasive phenotype in three-dimensional cultures. Constitutive activation of the extracellular signal-regulated kinase (ERK) pathway also enhanced PDEF-induced motility and invasion, suggesting that activation of the ERK/mitogen-activated protein kinase by ErbB2 and CSF-1R/CSF-1 can cooperate with PDEF to promote motility and invasion. Furthermore, PDEF promoted anchorage-independent growth of ErbB2 and CSF-1R/CSF-1-expressing cells. Using laser capture microdissection, we also found that PDEF mRNA is overexpressed in breast tumor epithelia throughout tumor progression. Taken together, these findings suggest that the transcription factor PDEF may play an important role in breast tumorigenesis and that PDEF overexpression may be particularly significant in tumors that exhibit activation of oncogenic RTKs such as ErbB2 and CSF-1R.
Functional Regression Analysis of Fluorescence Curves (2008)

Fluorescence curves are useful for monitoring changes in photosynthesis activity. Various summary measures have been used to quantify differences among fluorescence curves corresponding to different treatments, but these approaches may forfeit valuable information. As each individual fluorescence curve is a functional observation, it is natural to consider a functional regression model. The proposed model consists of a nonparametric component capturing the general form of the curves and a semiparametric component describing the differences among treatments and allowing comparisons of treatments. Several graphical model-checking approaches are introduced. Both approximate, asymptotic confidence intervals as well as simulation-based confidence intervals are available. Analysis of data from a crop experiment using the proposed model shows that the salient features in the fluorescence curves are captured adequately. The proposed functional regression model is useful for analysis of high throughput fluorescence curve data from regular monitoring or screening of plant growth.
A linear ultrasonic motor for nano-technology (1996)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1996.
Polar Discontinuity Doping of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mi>LaVO</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo>/</mml:mo><mml:msub><mml:mi>SrTiO</mml:mi><mml:mn>3</mml:mn></mml:msub></mml:math>Interface (2007)

We have investigated the transport properties of LaVO_{3}/SrTiO_{3} Mott-insulator-band-insulator heterointerfaces for various configurations. The (001)-oriented n-type VO_{2}/LaO/TiO_{2} polar discontinuity is conducting, exhibiting a LaVO3 thickness-dependent metal-insulator transition and low temperature anomalous Hall effect. The (001) p-type VO_{2}/SrO/TiO_{2} interface, formed by inserting a single layer of bulk metallic SrVO3 or SrO, drives the interface insulating. The (110) heterointerface is also insulating, indicating interface conduction arising from electronic reconstructions.
Hyperspectral imaging applied to microbial categorization in an automated microbiology workflow (2015)

Hyperspectral imaging (HSI) is being evaluated as a pre-selection tool to categorize and localize populations of microbial colonies directly onto their culture medium, in order to facilitate the microbiology workflow downstream the incubation step. The categorization criteria were here limited to the diffuse radiance spectra acquired mostly in the visible region between 400 and 900 nm. Although the diffuse radiance signal is much broader than the one acquired using vibrational techniques such as Raman and IR and limited to chromophores absorbing in the visible region, it can be acquired very quickly allowing to perform hyperspectral imaging of large objects (i.e. Petri dishes) with throughputs that are compatible with the needs of a clinical laboratory workflow. Moreover, additional cost reduction could possibly be achieved using application-specific multispectral systems. Furthermore, recent research has shown that good power of discrimination, at the species level, could be achieved at least for a low level of species. In our work, we test different culture media, with and without a strong light absorption in the visible region, and report categorization results obtained when selecting end-member spectra according to a multi-parametric study (colonies, agar type). Results of categorization (e.g. at the species level) are presented using two types of supervised-categorization algorithms providing that they deliver subpixel fractional abundance information (Linear Spectral Unmixing type) or not such as Spectral Angle Mapping (SAM) and Euclidian Distance (ED) type. Interestingly the performance between the two classes of algorithms is dramatically different, a trend which is not always observed. An interpretation is proposed on the basis of the agar interference and the spectral purity of end-member spectra.
Current polarity detection-based simple position sensorless drive of IPMSM for AC compressor in HEV (2004)

A position sensorless control approach for IPMSM proposed in this paper is specifically developed for air conditioning compressor drives in hybrid electric vehicles. For stable sensorless operation, it makes the best use of two beneficial aspects appearing in the motor under the sinusoidal PWM voltage drive without any current minor loops. Unlike traditional sensorless approaches being on the basis of d-q vector control, neither complex computation tasks nor external precise current sensors are necessary. Therefore, it is suitable for low cost implementation of variable speed drives. The theoretical and experimental studies using 2.2 kW-6700 rpm IPMSM show the proposed sensorless drive meets the requirements for the target application. Moreover, the dynamic simulator of the controller built up on MATLAB/SIMULINK also demonstrates the validity of the proposed sensorless control approach.
Uncarine C, D (speciophylline), E, and F: C-3 and C-7 epimeric oxindoles related to tetrahydroalstonine (1967)

N. K. Hart, S. R. Johns and J. A. Lamberton, Chem. Commun. (London), 1967, 87 DOI: 10.1039/C19670000087
Beitrag zur Kenntnis des Sitosterins und des Stigmasterins (1915)

KCy Nech 1 Woche %,06 ccm
Immune Cell Distribution in Gut-Associated Lymphoid Tissue and Synthesis of IL-6 in Experimental Porcine Peritonitis (2000)

This study aimed to evaluate the possibility to detect early changes in gut-associated lymphoid tissue related to an inflammatory response. Anaesthetised pigs were subjected to faecal peritonitis (n = 9) or to a sham procedure (n = 8). Blood from the vena cava and the superior mesenteric vein was repeatedly sampled, and the levels of interleukin-6 (IL-6) were analysed. Biopsies of the small intestine and mesenteric lymph nodes (MLNs), harvested at 300 min, were incubated with monoclonal antibodies specific for CD2 (T lymphocytes), IgM (B lymphocytes) and CD11a/CD18 (leucocyte adhesion molecule). The number of positive (+) cells was scored. During peritonitis, IL-6 increased significantly. Compared to controls, the number of CD2+ cells decreased, IgM+ cells tended to increase and CD11a/CD18+ cells increased in the mucosa during peritonitis. In MLNs, the number of cells positive for all studied markers increased during peritonitis. We conclude that peritonitis causes an inflammatory response in the gut reflected by changes in the distribution of immune cells in gut-associated lymphoid tissue and release of IL-6 to venous blood.
Effect of Target Luminance on Optimum Pupil Diameter for Presbyopic Eyes (2016)

A fixed 2- to 3-mm small pupil or a 30% pupil miosis can both produce near visual acuity gains without significant losses to distance acuity or image quality, and therefore can be considered as optimal for a presbyope experiencing a wide range of light levels.
Design Concepts for High-Power PIN Diode Limiting (1967)

Experimental data and discussion are presented which show the desirability of using thick punch-through PIN diode for high-power limiting. The slower speed of response sets an upper limit on thickness. Data are presented on the maximum thickness allowable as a function of frequency. Results are given for a high-peak-power narrow-pulsewidth receiver protector, and for a high-average-power wide-pulsewidth balanced duplexer. These devices are compared to conventional gas T-R tubes and results suggest that the use of multiple PIN diodes in limiters and duplexers can offer significant improvements in some RADAR applications.
Homogenous rapid detection of nucleic acids using two-color quantum dots (2006)

We report a homogenous method for rapid and sensitive detection of nucleic acids using two-color quantum dots (QDs) based on single-molecule coincidence detection. The streptavidin-coated quantum dots functioned as both a nano-scaffold and as a fluorescence pair for coincidence detection. Two biotinylated oligonucleotide probes were used to recognize and detect specific complementary target DNA through a sandwich hybridization reaction. The DNA hybrids were first caught and assembled on the surface of 605 nm-emitting QDs (605QDs) through specific streptavidin-biotin binding. The 525 nm-emitting QDs (525QDs) were then added to bind the other end of DNA hybrids. The coincidence signals were observed only when the presence of target DNA led to the formation of 605QD/DNA hybrid/525QD complexes. In comparison with a conventional QD-based assay, this assay provided high detection efficiency and short analysis time due to its high hybridization efficiency resulting from the high diffusion coefficient and no limitation of temperature treatment. This QD-based single-molecule coincidence detection offers a simple, rapid and ultra sensitive method for genomic DNA analysis in a homogenous format.
Projection-Pursuit Approach to Robust Dispersion Matrices and Principal Components: Primary Theory and Monte Carlo (1985)

Abstract This article proposes and discusses a type of new robust estimators for covariance/correlation matrices and principal components via projection-pursuit techniques. The most attractive advantage of the new procedures is that they are of both rotational equivariance and high breakdown point. Besides, they are qualitatively robust and consistent at elliptic underlying distributions. The Monte Carlo study shows that the best of the new estimators compare favorably with other robust methods. They provide as good a performance as M-estimators and somewhat better empirical breakdown properties.
State replication for multiplayer games (2002)

Massive multiplayer games have to cope with scalability problems that arise from the necessity of supporting network traffic for different game elements concurrently. In this paper, we show a simple means of separating these traffic styles in a proxy architecture by defining levels of urgency and relevance for each style. With this simple separation, low latency traffic styles can be preferred effectively over other traffic within the same game.We continue with a proposal for a middleware approach to the use of this infrastructure. It is based on the assumption that game developers can specify static requirements for the distributed objects at design and development time. In this case, we propose a combination of code-generation and run-time support for the use of the network architecture.
9.3: Sub-bandgap photoemission correlated with adsorbed molecules and bulk impurities in diamond (2010)

We report on photoemission images from NEA diamond using sub-bandgap and near-bandgap photon energies. Emission can be stimulated with photon wavelengths as low as 365 nm, but the low-energy emission disappears after heating the diamond to 700°C, while emission stimulated with 254 and 224 nm photons remains. In both cases the emission occurs only where the concentration of bulk point defects is low. We explain this behavior as the result of photon absorption both in the bulk and at the surface competing with bulk recombination.
Involvement of N‐Linked Carbohydrate Chains of Pig Zona Pellucida in Sperm‐Egg Binding (1995)

The sperm receptor activity of pig zona pellucida has been previously shown to exist in one of the components, pig zona protein 3 alpha (PZP3 alpha), that can be purified after the removal of sialylated and/or sulfated N-acetylpoly(lactosamine) by digestion with endo-beta-galactosidase. In this study, we examined whether N-linked or O-linked carbohydrate chains are involved in the sperm receptor activity of pig zona pellucida. The elimination of N-linked carbohydrate chains from endo-beta-galactosidase-digested PZP3 alpha by digestion with N-glycanase markedly reduced its inhibitory effect on sperm-egg binding in an in vitro competition assay, whereas the elimination of O-linked carbohydrate chains by alkali treatment hardly reduced the inhibitory effect. These results indicate that N-linked carbohydrate chains of PZP3 alpha play a major role in mediating the sperm binding of zona pellucida in pig.
Magnetic Resonance Imaging in Multiple Sclerosis (2002)

Magnetic resonance imaging (MRI) has become the primary technique with which neurologists support the diagnosis of multiple sclerosis (MS), and with which researchers monitor disease evolution in both natural history studies and treatment trials. This review summarises the contribution of brain and spinal cord MRI to the diagnosis of MS, illustrating the appearance of MS pathology on the most common MRI sequences. We also discuss the differences in MRI findings between the clinical types of MS and the development of newer non-conventional sequences. <b>THE CONTRIBUTION OF MRI TO THE DIAGNOSIS OF MS</b> The first application of MRI in MS was described in 1981. Since then, MRI of MS has rapidly evolved and new acquisition techniques, characterised by increased sensitivity and specificity with respect to pathology, have been developed. MRI is now an important paraclinical tool for the diagnosis of MS because it allows detection of MS lesions <i>in vivo</i> throughout
N,N-Dimethyl-5-Methoxytryptamine, a Component of a Dart Poison of the Yanoáma Indians (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN,N-Dimethyl-5-Methoxytryptamine, a Component of a Dart Poison of the Yanoáma IndiansC. Galeffi, I. Messana, and G. B. Marini BettoloCite this: J. Nat. Prod. 1983, 46, 4, 586–587Publication Date (Print):July 1, 1983Publication History Published online1 July 2004Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/np50028a029https://doi.org/10.1021/np50028a029research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Simplifying administration through dynamic reconfiguration. in a cooperative cluster storage system (2005)

Cluster storage systems where storage devices are distributed across a large number of nodes are able to reduce the I/O bottleneck problems present in most centralized storage systems. However, such distributed storage devices are hard to manage efficiently. In this paper, we examine the use of explicit, component-based (command and data) paths between hosts and disks as a vehicle for performing nondisruptive storage system reconfiguration. We describe the mechanisms necessary to perform reconfigurations and show how they can be used to handle two management tasks: migration between network technologies and rebuilding a disk in a mirror. Our approach is validated through initial performance measurements of these two tasks using a prototype implementation. The results show that online reconfiguration is possible at a modest cost
Fabricating the AuPdPt Ternary Nanophase Diagram at 800 °C To Guide the Exploration of Optimal Catalyst for <i>n</i>-Hexane Oxidation (2017)

A good knowledge of nanophase diagrams is critical to understanding the performance of nanomaterials. Herein, we for the first time fabricate a AuPdPt ternary nanophase diagram at 800 °C by experimental means. The solid-state synthesis strategy enables a precise synthesis of AuPdPt trimetallic nanoparticles with a full range of compositions and desired size distributions. By studying the phase behavior of those TMNPs, we succeed in mapping out the boundary curve and tie lines. Interestingly, the AuPdPt nanophase boundary shifts obviously to the Au-rich region as compared to the case of the corresponding bulk diagram, likely due to the combination of size and composition effects. Besides, owing to the different solubility of Pd in Au-rich and Pt-rich matrix, some tie lines do not parallel the baseline. These observations greatly improve our basic understanding of nanophase diagrams and are expected to be valuable references for other systems. Moreover, the as-fabricated nanophase diagram is successfully applied to guide the optimization of AuPdPt TMNPs catalysts for n-hexane oxidation.
The Economy of the Digital Gift: From Socialism to Sociality Online (2016)

This article discusses the value of gift exchange in online social media. In the first part, the authors show how most of the commentators have considered online gifting as an alternative to the classical market economy. Yet the recent (re)territorialization of the web challenges this perspective. As a consequence, the internet can no longer be considered a reply to capitalism. In the second part, the authors argue that in anthropology and social philosophy the term ‘gift’ has often been used improperly, and that gift exchange has nothing to do with goods exchange, but with mutual recognition. In the third part, they use this definition to stress the importance of gift circulation through Facebook’s ‘Like’ button and the Twitter feature called ‘Mention’. In conclusion, the authors deal with the ‘Like economy’, i.e. the interference between gift exchange and market economy which is daily at work online.
Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data (2018)

Following publication of the original article [1], it was reported that the incorrect "Additional file 3" was published. The correct additional file is given below.
Wheat E<sub>c</sub> metallothionein genes (1992)

A cDNA library was prepared from the bulk mRNA of mature wheat embryos and screened with mixed 32P-labeled oligonucleotide probes that encoded parts of the partial amino-acid sequence for the Zn-containing Ec protein. Each DNA insert in 11 positives from a screen of 10(5) plaques encoded a 5' untranslated and a 3' untranslated region, in addition to an open reading frame (of 81 amino acids) which, in every case, corresponded to at least 56 of the 59 amino acids in the partial polypeptide sequence previously determined for the Ec protein. The three different mRNA sequences encoded in the cDNA probably correspond to single-copy genes in the A, B and D genomes of hexaploid wheat. A wheat genomic library was screened with 32P-labeled cDNA and gave a single positive in a screen of 5 x 10(5) plaques. A 3.1-kb genomic fragment (gf-3.1) was sequenced and a cap site for the encoded mRNA was determined by primer extension. The gf-3.1 sequence encodes an intronless mRNA for the Ec protein and contains appreciable amounts of 5' and 3' flanking sequences. In addition to a putative TATA box, two inverted-repeat sequences and one direct-repeat sequence, the 5' flank in gf-3.1 contains a sequence similar to the abscisic-acid-responsive element in other higher-plant genes but does not contain sequences similar to the metal-responsive elements in animal metallothionein genes. Consistent with these findings, RNA blotting shows that accumulation of Ec mRNA is abundant in immature embryos, undetectable in germinated embryos and can be induced by adding abscisic acid, but not by adding Zn2+ to the medium in which mature wheat embryos are germinated. The findings suggest that the wheat Ec metallothionein genes, like mammalian liver metallothionein genes, are conspicuously expressed during embryogenesis.
The Future of Genomic Profiling of Neurological Diseases Using Blood (2006)

Sequencing of the human genome and new microarray technology make it possible to assess all genes on a single chip or array. Recent studies show different patterns of gene expression related to different tissues and diseases, and these patterns of gene expression are beginning to be used for diagnosis and treatment decisions in various types of lymphoid and solid malignancies. Because of obvious problems obtaining brain tissue, progress in genomics of neurological diseases has been slow. To address this, we demonstrated that different types of acute injury in rodent brain produced different patterns of gene expression in peripheral blood. These animal studies have now been extended to human studies. Two groups have shown that there are specific genomic profiles in the blood of patients after ischemic stroke that are highly sensitive and specific for predicting stroke. Other recent studies demonstrate specific genomic profiles in the blood of patients with Down syndrome, neurofibromatosis, tuberous sclerosis, Huntington disease, multiple sclerosis, Tourette syndrome, and others. In addition, data demonstrate specific profiles of gene expression in the blood related to different drugs, toxins, and infections. Although all of these studies are still preliminary basic scientific endeavors, they suggest that this approach will have clinical applications to neurological diseases in humans.