gebhart/patrepeval huggingface dataset:
Renal Stem Cells Research and Applications (2010)

This article is to try describing the renal stem cells in animal and to explore the methods to either repair or regenerate a damaged kidney with stem cells. For this purpose, the 3 sections are concerned: (1) Isolation of stem cells from animal embryo and/or other resources (such as adipose and renal tissue). (2) Embryonic stem (ES) cells differentiate into renal stem cells and/or renal progenitor cells. (3) Renal stem and/or progenitor cells differentiated from ES cells are used for renal repair and/or regeneration. The stem cell treatment can be the most hopeful technique on the renal repair and regenerate. [Stem Cell. 2010;1(1):30-51] (ISSN 1545-4570).
High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck (2007)

Nonmelanoma skin cancers (squamous cell and basal cell carcinomas) occur at an epidemic rate in many countries with the worldwide incidence increasing. The sun-exposed head and neck are the most frequent sites for these cancers to arise and in most patients diagnosed with a cutaneous squamous cell carcinoma, local treatment is usually curative. However, a subset is diagnosed with a high-risk cutaneous squamous cell carcinoma. High-risk factors include size (>2 cm), thickness/depth of invasion (>4 mm), recurrent lesions, the presence of perineural invasion, location near the parotid gland, and immunosuppression. These patients have a higher risk (>10-20%) of developing metastases to regional lymph nodes (often parotid nodes), and in some cases also of experiencing local morbidity (perineural invasion), based on unfavourable primary lesion and patient factors. Despite treatment, many patients developing metastatic cutaneous squamous cell carcinoma experience mortality and morbidity usually as a consequence of uncontrolled metastatic nodal disease. It is therefore important that clinicians treating nonmelanoma skin cancers have an understanding and awareness of these high-risk patients. The aim of this article is to discuss the factors that define a high-risk patient and to present some of the issues pertinent to their management.
Poverty : some measurement problems (1977)

There are a number of well-known difficulties in the interpretion and projection of cross-sectional relationships over time. One problem is the assumption that the parameters of a cross-sectional relationship used for temporal projections are stable over time. Also, using relationships and descriptions related to one point in time may not truly indicate a long run structural aspect of an economy. In addition, the definition and measurement of a poverty line are also complicated. A poverty line may be defined as the cost of a bundle of basic goods or may be defined as a nutritional norm such as required intake of calories. A number of measurement problems arise using either approach. Even if an adequate definition of poverty is available, the interrelationships between policies to abate poverty are not solidly established. The aim of policy should be to create the decision environment through appropriate incentives. The lack of knowledge about the relationships between fertility, health, nutrition, and education inhibits effective policy formulation. Given the severity of the measurement problem, any unidimensional description of the nature of poverty should be avoided. 34 references.
MetaQUAST: evaluation of metagenome assemblies (2015)

Supplementary data are available at Bioinformatics online.
Optical amplification in Er/sup 3+/-doped single-mode fluoride fiber (1990)

The amplification characteristics at around 1.5 mu m of a 0.9-m-long, 1000-p.p.m Er/sup 3+/-doped single-mode fluoride fiber are discussed. By using 1.48- mu m laser diodes with 55-mW launched output as a pump source, a gain of 1.75 dB was obtained at 1.530 mu m. A broad bandwidth of 40 nm was obtained, which may be suitable for wavelength-division multiplexing (WDM) system use.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Production of Human Natural Killer Cells for Adoptive Immunotherapy Using a Computer-Controlled Stirred-Tank Bioreactor (1996)

Large-scale ex vivo expansion of human natural killer (NK) cells for adoptive immunotherapy requires assurance of good manufacturing practices. However, maximal expansion of NK is also desired to facilitate clinical trials with large numbers of IL-2-activated NK (ANK). A closed-system stirred-tank bioreactor is amenable to computer control of culture variables, thereby reducing the risk of contamination. We demonstrate that NK cultured in 250-ml spinner flasks expand 2.5-fold more than NK cultured in stationary tissue culture wells. We further show that during 33 days of culture, it is feasible to control the pH between 7.0 and 7.2 and the dissolved oxygen concentration at 40% of air saturation via direct on-line computer control in a 750-ml stirred-tank bioreactor. On-line measurement of optical density by a laser turbidity sensor, as a measure of cell concentration, correlated well with actual cell count data. NK expansion in the 750-ml bioreactor was 7-fold greater than in stationary tissue culture controls and 3-fold greater than in spinner flask controls. Consumption rates of glucose and oxygen and the production rate of lactate were measured and will be used to develop a nutrient feeding strategy to convert the batch reactor experiment into closed-system fed-batch or continuous flow modes. Computer-controlled stirred-tank bioreactors may facilitate clinical trials with high-purity ANK populations for adoptive immunotherapy.
Applying machine learning to detect individual heart beats in ballistocardiograms (2010)

Ballistocardiography is a technique in which the mechanical activity of the heart is recorded. We present a novel algorithm for the detection of individual heart beats in ballistocardiograms (BCGs). In a training step, unsupervised learning techniques are used to identify the shape of a single heart beat in the BCG. The learned parameters are combined with so-called "heart valve components" to detect the occurrence of individual heart beats in the signal. A refinement step improves the accuracy of the estimated beat-to-beat interval lengths. Compared to other algorithms this new approach offers heart rate estimates on a beat-to-beat basis and is designed to cope with arrhythmias. The proposed algorithm has been evaluated in laboratory and home settings for its agreement with an ECG reference. A beat-to-beat interval error of 14.16 ms with a coverage of 96.87% was achieved. Averaged over 10 s long epochs, the mean heart rate error was 0.39 bpm.
Estimation of the Level of Blood Alcohol from Analysis of Breath. II. Use of Rebreathed Air (1956)

Alcohol analyses were conducted with rebreathed air, finger-tip capillary blood, and cubital-vein blood from 31 human subjects, with the three samples taken almost simultaneously 1, 2, and 3 hours after ingestion of whisky. Details of the study are described and the results are discussed. It was found that during the first 70 minutes after drinking, the alcohol level of capillary blood averaged 7.5 % above that of venous blood, and was 15 to 22 % higher in 7 of the 34 pairs of samples. Later samples showed no significant difference between blood from these two sources. It is noted that for estimating blood alcohol level, the rebreathed air method is definitely an improvement over Drunkometer methods. With the rebreathed air procedure, a determination of breath carbon dioxide is unnecessary.
Enhanced co-orientation in the perception of friends: A social relations analysis. (1994)

Newcomb's (1953) idea of co-orientation (interdependence between two persons' attitudes or perceptions) is used as a framework within which interpersonal perception between friends and acquaintances is examined. The principal question is whether co-orientation effects are stronger for friendship dyads than for acquaintance dyads. More specifically, the study examines the degree to which consensus, assimilation, self-other agreement, and assumed similarity differ. The social relations model is used to analyze a data set that included 16 living groups with 119 friend dyads and 1.668 acquaintance dyads. Results indicate that co-orientation effects are more pronounced in friendship dyads. The increment in co-orientation effects is largely due to similarities in the unique or idiosyncratic perceptions that people have of friendship pairs as well as the unique agreement about others that friends have with one another.
Self-assembly of a High-Nuclearity Chloride-Centered Copper(II) Cluster. Structure and Magnetic Properties of [Au(PPh<sub>3</sub>)<sub>2</sub>][<i>trans</i>-Cu<sub>6</sub>(μ-OH)<sub>6</sub>{μ-(3,5-CF<sub>3</sub>)<sub>2</sub>pz}<sub>6</sub>Cl] (2007)

A chloride-centered hexanuclear copper(II) pyrazolate [Au(PPh3)2][trans-Cu6(micro-OH)6[micro-(3,5-CF3)2pz]6Cl] is isolated from the reaction of the trinuclear copper(I) pyrazolate [Cu3[micro-(CF3)2pz]3] with PPh3AuCl and Ph3P in moist air. The six copper atoms are bridged by pyrazolate and hydroxyl ligands, above and below the copper plane. The chloride anion exists at the center of the planar cavity formed by the copper atoms with Cu-Cl distances of 3.02-3.13 A. The magnetic susceptibility measurements show a strong antiferromagnetic coupling between the copper centers with an estimated exchange constant of J approximately 650 cm-1.
SUBSTITUTED 1,10-PHENANTHROLINES. VIII. 2- AND 3-PHENYL DERIVATIVES<sup>1</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSUBSTITUTED 1,10-PHENANTHROLINES. VIII. 2- AND 3-PHENYL DERIVATIVES1FRANCIS H. CASE and RICHARD SASINCite this: J. Org. Chem. 1955, 20, 10, 1330–1336Publication Date (Print):October 1, 1955Publication History Published online1 May 2002Published inissue 1 October 1955https://pubs.acs.org/doi/10.1021/jo01127a006https://doi.org/10.1021/jo01127a006research-articleACS PublicationsRequest reuse permissionsArticle Views828Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antiproliferative, antiangiogenic and proapoptotic activity of h‐R3: A humanized anti‐EGFR antibody (2002)

The epidermal growth factor receptor (EGFR) proto-oncogene is frequently overexpressed in tumors of epithelial origin. This event is thought to be causative for tumor development and progression and henceforth associated with poor prognosis. The recent considerable interest in developing EGFR-targeting agents resulted in derivation of the monoclonal, humanized, neutralizing antibody h-R3, which binds to the extracellular domain of EGFR with high affinity and strongly inhibits EGFR-dependent cellular transformation. Thus, treatment of A431 squamous cell carcinoma cells with h-R3 in either 2-dimensional or 3-dimensional culture resulted in appreciable antimitotic effects through induction of the G1 arrest. Although h-R3 does not appear to have a direct proapoptotic activity in this setting, it inhibits production of the vascular endothelial growth factor (VEGF) by A431 cells both in vitro and in vivo. In the latter case, h-R3 treatment (0.25-1 mg/mouse; every other day per 2 weeks) not only significantly reduced VEGF mRNA expression of A431 tumors growing subcutaneously in SCID mice but also resulted in reduction of the overall microvascular density (MVD), disappearance of dilated "mother vessels," as well as in suppression of tumor growth followed by regression of established tumors. This apparent antiangiogenic activity of h-R3 was associated with reduction in Ki67-positive tumor cell fraction and (unlike in vitro) also with an elevated apoptotic index, the latter indicative of a cytotoxic mode of action in vivo. Taken together, h-R3 is a promising new antagonist of the EGFR oncogene, the anticancer properties of which are associated with combined and potent antiproliferative, antiangiogenic and proapoptotic activity.
Phase II study of flutamide in the treatment of hepatocellular carcinoma (1996)

BACKGROUND Hepatocellular carcinoma (HCC) is a male predominant disease and may be an androgen-dependent or androgen-responsive tumor. This Phase II study was designed to investigate the clinical activity and toxicity of flutamide in the treatment of patients with advanced HCC. METHODS Thirty-two patients with measurable advanced HCC were studied. Flutamide, 750 mg per day, was administered orally for 8 weeks. Ten patients died before repeat tumor measurements could be performed. RESULTS Twenty-two patients were evaluable for response and toxicities. There were no complete responses nor partial responses. Nine of 22 patients (41%) had stable disease and 13 patients (59%) had progressive disease. Serum alpha-fetoprotein was reduced in three patients. The median survival was 10 weeks (range, one to 35 weeks). Toxicities were minimal and tolerable. CONCLUSIONS Flutamide is not effective in the treatment of advanced HCC. Clinically, HCC may not be an androgen-responsive tumor. Other new methods of treatment of HCC warrants future clinical investigations. Cancer 1996; 77:635-9.
A new low‐image‐lag drive method for large‐size LCTVs (1993)

Abstract— A new low‐image‐lag drive method is proposed for large‐size LCTVs, taking into account the input signal and inter‐field differential signal dependence of the response time. It was shown that the gray‐level response time was 30–60 ms, which is 2–3 times as long as the ON‐OFF bi‐level response time, and was expressed as a linear function of the input voltage. With the new level adaptive overdrive (LAO) method, the response time was reduced to 17 ms, which is about one‐half to one‐third that of the conventional method and is satisfactory for TV applications. A 10.4‐in. panel has been used to verify the effect of LAO on image quality. Moving images have been clearly observed using the LAO method.
Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome. (1990)

Autoantibodies present in the sera of patients with bullous pemphigoid (BP) bind to the basement membrane zone of normal human skin and commonly recognize two epidermal proteins, the BP240 and BP180 antigens. Two BP antigen cDNA clones from a lambda gt11 human keratinocyte library have been identified on the basis of reactivity with a BP serum. The fusion protein (FP) produced by one clone immunoadsorbed autoantibodies, which specifically recognized the BP180 by antigen, showing no cross-reactivity with BP240 by immunoblot analysis. The FP produced by the second clone immunoadsorbed autoantibodies which specifically reacted with the BP240 epidermal antigen. Northern blot analysis demonstrated that the BP180 and BP240 antigens are encoded by distinct RNA transcripts with lengths of 6.0 and 8.5 kb, respectively. Immunoblot analysis of the BP180 lysogen extract identified a 135-kD FP which was recognized by 7 of 16 BP sera and 7 of 8 herpes gestationis sera. A rabbit antiserum prepared against the lysogenic BP180 FP specifically recognized the BP180 antigen from human epidermal extracts by immunoblotting, labeled the BMZ by indirect immunofluorescence, and bound to human epidermal hemidesmosomes by immuno-electron microscopy. These results indicate that the BP180 antigen recognized by BP and herpes gestationis autoantibodies is a unique hemidesmosomal polypeptide, distinguishable from the BP240 antigen.
Aesthetic Measure Applied to Color Harmony* (1944)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Parry Moon and Domina Eberle Spencer, "Aesthetic Measure Applied to Color Harmony*," J. Opt. Soc. Am. 34, 234-242 (1944) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Three-dimensional kaleidoscopic imaging (2011)

We introduce three-dimensional kaleidoscopic imaging, a promising alternative for recording multi-view imagery. The main limitation of multi-view reconstruction techniques is the limited number of views that are available from multi-camera systems, especially for dynamic scenes. Our new system is based on imaging an object inside a kaleidoscopic mirror system. We show that this approach can generate a large number of high-quality views well distributed over the hemisphere surrounding the object in a single shot. In comparison to existing multi-view systems, our method offers a number of advantages: it is possible to operate with a single camera, the individual views are perfectly synchronized, and they have the same radiometric and colorimetric properties. We describe the setup both theoretically, and provide methods for a practical implementation. Enabling interfacing to standard multi-view algorithms for further processing is an important goal of our techniques.
Miscible Gas/Oil Gravity Drainage (2006)

Abstract Oil recovery from oil and mixed-wet naturally fractured reservoirs is difficult. Standard production mechanisms like water injection and countercurrent imbibition will not work. Gas–oil gravity drainage (GOGD) is then the production mechanism of choice. Gravity drainage with immiscible/ solution gas can result in low production rates and/or high residual oil saturation due to capillary holdup. When the injected gas is miscible with the oil, density and viscosity reduction will occur. Miscibility adds the advantages of single-phase flow and interfacial tension reduction, which further improves GOGD rates and ultimate recovery. The paper discusses the modeling and upscaling of first contact miscible gravity drainage as well as the differences from regular gas injection processes. The key parameters for this case were identified to be width over height ratio, layering heterogeneity and gas recycling rate. First contact miscible gas injection benefits the most from the IFT reduction and is most suitable in heterogeneous reservoirs with large capillary hold up and re-imbibition effects.
Packed hyper-ellipsoid classifiers (1994)

Pattern classification is frequently performed using the k-nn algorithm or a neural network. The choice of parameters for the former is often difficult and the amount of data which has to be stored in the classifier can be high. Neural network classifiers can overcome some of these problems but learning is often unreliable and slow. An alternative which combines some of the best features of the k-nn and neural network classifier is decribed by the authors. The classifier is called a packed hyper-ellipsoid classifier.
Action of the Aqueous Extract of Sesamum Radiatum Schum. & Tonn.(Pedaliaceae) on the Cardiovascular System of Mammalians: Hypotensive Effect (2006)

The effects of the aqueous extract of Sesamum radiatum Schum & Tonn (ESera) were studied on the cardiovascular system of mammalians. ESera administered intravenously (6 x 10-4 g/kg b.w. - 5.7 x 10-2 g/kg b.w.), caused a decrease in the arterial blood arterial pressure (hypotension) in a dose-dependent manner (ED50 =0 1.3 x 10-2 g/kg b.w.). These effects induced by ESera were reversed in the presence of atropine at a concentration of 10-8 g/kg b.w. Our observations regarding the isolated heart of rat showed that the extract induced both negative inotropic and negative chronotropic effects. Similarly, the experimentation based on the isolated aorta obtained from guinea pig revealed that the extact decreased the basal tonus of this smooth muscle. These results suggest that ESera could act via cholinergic receptors. The effects of ESera could result from both cardiodepression and vasorelaxation mechanism.
Symmetry analyzer for nondestructive Bell-state detection using weak nonlinearities (2005)

We describe a method to project photonic two-qubit states onto the symmetric and antisymmetric subspaces of their Hilbert space. This device utilizes an ancillary coherent state, together with a weak cross-Kerr nonlinearity, generated, for example, by electromagnetically induced transparency. The symmetry analyzer is nondestructive, and works for small values of the cross-Kerr coupling. Furthermore, this device can be used to construct a nondestructive Bell-state detector.
Current Options for the Treatment of Facial Angiofibromas (2014)

Facial angiofibromas are hamartomatous growths that are closely associated with tuberous sclerosis complex and, in fact, they constitute one of the main diagnostic criteria for that disease. These lesions composed of blood vessels and fibrous tissue appear on the face at an early age. Since they have important physical and psychological repercussions for patients, several treatment options have been used to remove them or improve their appearance. However, the lack of treatment guidelines prevents us from developing a common protocol for patients with this condition. The present article aims to review the treatments for facial angiofibromas used to date and to propose a new evidence-based treatment protocol. Los angiofibromas faciales son tumoraciones hamartomatosas íntimamente relacionadas con el complejo de la esclerosis tuberosa, y representan uno de los criterios mayores para el diagnóstico de la enfermedad. Su aparición desde edades tempranas en la región facial, así como su naturaleza fibrovascular, producen importantes repercusiones físicas y psicológicas en estos pacientes, lo que ha motivado la utilización de múltiples tratamientos para su eliminación o mejora. Sin embargo, no existen guías de tratamiento que permitan establecer un protocolo de actuación común en este tipo de pacientes. El objetivo de este artículo es revisar los tratamientos utilizados hasta la fecha para los angiofibromas faciales en función de la evidencia científica demostrada e intentar aportar un protocolo terapéutico.
PARP1-dependent Kinetics of Recruitment of MRE11 and NBS1 Proteins to Multiple DNA Damage Sites (2007)

Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme that is rapidly activated by DNA strand breaks and signals the presence of DNA lesions by attaching ADP-ribose units to chromatin-associated proteins. The therapeutic applications of PARP inhibitors in potentiating the killing action of ionizing radiation have been well documented and are attracting increasing interest as a cancer treatment. However, the initial kinetics underlying the recognition of multiple DNA lesions by PARP1 and how inhibition of PARP potentiates the activity of DNA-damaging agents are unknown. Here we report the spatiotemporal dynamics of PARP1 recruitment to DNA damage induced by laser microirradiation in single living cells. We provide direct evidence that PARP1 is able to accumulate at a locally induced DNA double strand break. Most importantly, we observed that the rapid accumulation of MRE11 and NBS1 at sites of DNA damage requires PARP1. By determining the kinetics of protein assembly following DNA damage, our study reveals the cooperation between PARP1 and the double strand break sensors MRE11 and NBS1 in the close vicinity of a DNA lesion. This may explain the sensitivity of cancer cells to PARP inhibitors.