gebhart/patrepeval huggingface dataset:
Antigenicidad e inmunogenicidad de las proteínas de choque térmico (1997)

Los organismos eucariotas y procariotas responden frente a estímulos potencialmente dañinos, tales como temperaturas elevadas, aumentando la síntesis de una familia de proteínas conocidas como proteínas de choque térmico (HSPs) o proteínas de estrés. Las HSPs se encuentran entre las proteínas más conservadas y abundantes presentes en la naturaleza. Estas proteínas han generado un mayor interés desde que fueron descritas como antígenos dominantes de microorganismos infecciosos. Se ha sugerido que el reconocimiento por el sistema inmune de las HSPs del patógeno sirve como una primera línea de defensa al tiempo que es la forma por la que se puede desencadenar un proceso auto inmune como consecuencia de la aparición de una reactividad cruzada con las HSPs propias. Como una consecuencia de su función chaperona, las HSPs se encuentran asociadas a un amplio espectro de péptidos derivados de las células de las que estas proteínas se aislan. Por ello, no resulta sorprendente que los complejos HSP-péptidos se comporten como antígenos específicos de tumores. Resulta destacable que la vacunación con estos complejos HSP-péptidos induce respuestas inmunes protectivas frente al tumor del que fueron aislados dichos complejos. Finalmente, datos recientes indican que las características antigénicas de las HSPs pueden ser explotadas para aumentar la respuesta inmune humoral y celular frente a proteínas de interés.
Architecture and Robust Control of a Digital Frequency-Locked Loop for Fine-Grain Dynamic Voltage and Frequency Scaling in Globally Asynchronous Locally Synchronous Structures (2011)

International audience
Functional characterization of human variants of NFKBIA: a key regulator of immune responsiveness implicated in susceptibility to infectious and inflammatory disease (2010)

Objective/
Mobile device sensing system for urban goods distribution logistics (2017)

This paper presents a low cost mobile application (app) integrated on an Internet of Things (IoT) ecosystem, which uses varied sensor information collected by mobile devices to track and assist on the logistics of urban goods distribution processes. The proposed approach is leveraged by the trend of decreasing costs for mobile data communication in urban environments. Taking into account basic sensor data available in mobile devices (e.g., GPS, accelerometer and magnetometer), it is possible to track the users' movements and adopted routes, identify transit times and driving styles, identify the quality of roads, and track the process of loading/unloading of urban goods. This data can also be analyzed through a data mining process to identify patterns, present driving advice and perform a resource optimization process.
New Curing System Components (1987)

Abstract Asymmetric disulfides derived from dibutyldithiophosphoric acid and from 2-ethylamino-4-diethylamino-6-rnercapto- sym -triazine can be used in NR as nonreverting accelerators. A new accelerator, 2,2′-dithiobispyridine- N -oxide, behaves similarly. By using the appropriate combination of these accelerators with conventional benzothiazole based accelerators or with each other, scorch delay can be controlled and crosslinking rate can be increased. Significantly, reversion resistance can be greatly improved. These effects can now be achieved without any change in vulcanizate mechanical properties.
Higher Velocity Thermal Spray Processes Produce Better Aircraft Engine Coatings (1992)

<div class="htmlview paragraph">High velocity, oxy-fuel (HVOF) coatings are being used or considered for a number of aircraft engine applications (both OEM and overhaul). In most cases, HVOF coatings offer improved coating quality over previous plasma spray or combustion coatings. The superior coating quality is primarily a result of the higher particle velocities achieved with HVOF guns. HVOF coatings provide the following benefits:</div> <div class="htmlview paragraph">Higher density (lower porosity)</div> <div class="htmlview paragraph">Higher hardness</div> <div class="htmlview paragraph">Lower oxide content</div> <div class="htmlview paragraph">Better wear resistance</div> <div class="htmlview paragraph">Higher bond strength</div> <div class="htmlview paragraph">Improved corrosion barrier</div> <div class="htmlview paragraph">Smoother as-sprayed surfaces</div> <div class="htmlview paragraph">The various HVOF guns (JetKote, Diamond Jet, CDS, TopGun and JP-5000) are discussed and compared to other thermal spray processes (conventional combustion powder and wire guns, plasma spray and detonation gun). Special attention is given to the JP-5000, which produces particle velocities which are 1000 fps faster than the other HVOF guns. HVOF coating properties are described and illustrated.</div>
Suction blister transplantation for leg ulcers (1975)

Application of suction blister transplants to leg ulcers is an alternative symptomatic treatment to split-skin grafting, i.e. "pinch-grafting". Blisters are produced by the suction device Dermovac at a suction pressure of 250-300 mmHg for 1-2 hours. The blister-roofs are cut off at the periphery and placed on the granulation tissue of the ulcer. The healing time for leg ulcers was 10-14 days. Excellent epithelialization was seen in 10 out of 12 ulcers. The advantages of the method are, that it is easy to perform, no scarring is produced, and the procedure is painless.
Some More Hobson Verses (1948)

Research Article| March 01 1948 Some More Hobson Verses G. Blakemore Evans G. Blakemore Evans Search for other works by this author on: This Site Google Modern Language Quarterly (1948) 9 (1): 10. https://doi.org/10.1215/00267929-9-1-10 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation G. Blakemore Evans; Some More Hobson Verses. Modern Language Quarterly 1 March 1948; 9 (1): 10. doi: https://doi.org/10.1215/00267929-9-1-10 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsModern Language Quarterly Search Advanced Search The text of this article is only available as a PDF. Copyright © 1948 by Duke University Press1948 Article PDF first page preview Close Modal Issue Section: Articles You do not currently have access to this content.
Safety and immunogenicity of multiple conventional immunizations administered during early HIV infection. (1991)

Twenty-one asymptomatic adults who had recently received multiple polysaccharide, live viral, and protein-derived vaccines were identified as being infected with human immunodeficiency virus (HIV). The mean subject age was 24 years (range 18-33); 20 of 21 (95%) were male. The mean T4 count was 523/mm3 with a mean T4/T8 ratio of 0.6. Serologic responses to immunization with meningococcus group C, adenovirus types 4 and 7, tetanus, and diphtheria were evaluated for the HIV seropositive subjects and were compared with the responses of similarly vaccinated age-, sex-, and race-matched HIV-seronegative controls. Significantly fewer (p less than 0.03) HIV subjects responded to meningococcus C (bactericidal antibody) and adenovirus 4 (neutralizing antibody) vaccines than did normals; the HIV-infected subjects who did respond produced functional antibody comparable to that of normals. Booster responses of HIV subjects to tetanus and diphtheria were comparable to those of normals. HIV-infected vaccine nonresponders did not differ from HIV-infected responders in total white blood cell, T4, T4/T8, total serum IgG, or delayed-type hypersensitivity skin test reactivity. All HIV subjects had negative cultures for live vaccine viruses (rubella, measles, adenovirus, and poliovirus). Postimmunization, no clinically apparent adverse reactions to vaccination were detected.
Classification of Hyperspectral Images With Regularized Linear Discriminant Analysis (2009)

This paper analyzes the classification of hyperspectral remote sensing images with linear discriminant analysis (LDA) in the presence of a small ratio between the number of training samples and the number of spectral features. In these particular ill-posed problems, a reliable LDA requires one to introduce regularization for problem solving. Nonetheless, in such a challenging scenario, the resulting regularized LDA (RLDA) is highly sensitive to the tuning of the regularization parameter. In this context, we introduce in the remote sensing community an efficient version of the RLDA recently presented by Ye to cope with critical ill-posed problems. In addition, several LDA-based classifiers (i.e., penalized LDA, orthogonal LDA, and uncorrelated LDA) are compared theoretically and experimentally with the standard LDA and the RLDA. Method differences are highlighted through toy examples and are exhaustively tested on several ill-posed problems related to the classification of hyperspectral remote sensing images. Experimental results confirm the effectiveness of the presented RLDA technique and point out the main properties of other analyzed LDA techniques in critical ill-posed hyperspectral image classification problems.
A mutant pyruvate dehydrogenase E1 subunit allows survival of <i>Escherichia coli</i> strains defective in 1‐deoxy‐<scp>d</scp>‐xylulose 5‐phosphate synthase (2006)

The 2-C-methyl-D-erythritol 4-phosphate pathway has been proposed as a promising target to develop new antimicrobial agents. However, spontaneous mutations in Escherichia coli were observed to rescue the otherwise lethal loss of the first two enzymes of the pathway, 1-deoxy-D-xylulose 5-phosphate (DXP) synthase (DXS) and DXP reductoisomerase (DXR), with a relatively high frequency. A mutation in the gene encoding the E1 subunit of the pyruvate dehydrogenase complex was shown to be sufficient to rescue the lack of DXS but not DXR in vivo, suggesting that the mutant enzyme likely allows the synthesis of DXP or an alternative substrate for DXR.
Mechanism of Synergistic Effects of β-Lactam Antibiotic Combinations on Gram-Negative Bacilli (1973)

These studies were undertaken to elucidate further the mechanism of synergism of pairs of beta-lactam antibiotics on beta-lactamase-producing gram-negative bacilli. Three strains of gram-negative bacilli which elaborate beta-lactamase enzymes with widely differing properties were employed. The antibacterial effects of beta-lactam antibiotics, singly and in combination, on the three organisms investigated were exactly those which would have been predicted on the basis of the enzymological properties of the beta-lactamases elaborated by these organisms. The findings thus support the hypothesis that the synergistic antibacterial effects of combinations of beta-lactam antibiotics on these organisms were due to inhibition of the enzyme by one of the agents and killing of the organism by the other, which was protected from enzymatic hydrolysis, rather than the alternative possibility that the synergistic effects were due simply to the combined antibacterial actions of the two drugs.
High energy railgun designs (1984)

We have explored designs for electromagnetic launchers capable of accelerating large masses to hypervelocity. In examining segmented railgun designs we have identified several important considerations. Among these are: a) acceleration changes at segmentation points due to the effects of force pick-up, opening switch risetime and current feed geometry, b) opening switches with pulse compressions of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , and c) relations which determine sizing of segements and magnetic energy stores. In addition, we will discuss the relative merits of inverse railgun pulse generators (flux compressors) and HPG's for charging magnetic stores.
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2 (1998)

Mutations are introduced into rearranged Ig variable genes at a frequency of 10(-2) mutations per base pair by an unknown mechanism. Assuming that DNA repair pathways generate or remove mutations, the frequency and pattern of mutation will be different in variable genes from mice defective in repair. Therefore, hypermutation was studied in mice deficient for either the DNA nucleotide excision repair gene Xpa or the mismatch repair gene Pms2. High levels of mutation were found in variable genes from XPA-deficient and PMS2-deficient mice, indicating that neither nucleotide excision repair nor mismatch repair pathways generate hypermutation. However, variable genes from PMS2-deficient mice had significantly more adjacent base substitutions than genes from wild-type or XPA-deficient mice. By using a biochemical assay, we confirmed that tandem mispairs were repaired by wild-type cells but not by Pms2(-/-) human or murine cells. The data indicate that tandem substitutions are produced by the hypermutation mechanism and then processed by a PMS2-dependent pathway.
Network-centric feature-based modeling (2003)

Network and Internet technology opens up another domain for building future CAD/CAM environments. The environment will be global, network-centric, and spatially distributed. We present an approach for network-centric feature-based modeling in a distributed design environment. The presented approach combines the current feature-based modeling technique with distributed computing and communication technology for supporting product modeling and collaborative design activities over the network. The approach is implemented in a client/server architecture, in which Web-enabled feature modeling clients, neutral feature model server, and other applications communicate with one another via a standard communication protocol. The paper discusses how the neutral feature model supports multiple views and maintains naming consistency between geometric entities of the server and clients. Moreover, it explains how to minimize the network delay between the server and client according to incremental feature modeling operations.
Shape descriptors for non-rigid shapes with a single closed contour (2002)

The Core Experiment CE-Shape-1 for shape descriptors performed for the MPEG-7 standard gave a unique opportunity to compare various shape descriptors for non-rigid shapes with a single closed contour. There are two main differences with respect to other comparison results reported in the literature: (1) For each shape descriptor the experiments were carried out by an institute that is in favor of this descriptor. This implies that the parameters for each system were optimally determined and the implementations were thoroughly rested. (2) It was possible to compare the performance of shape descriptors based on totally different mathematical approaches. A more theoretical comparison of these descriptors seems to be extremely hard. In this paper we report on the MPEG-7 Core Experiment CE-Shape.
Magnetic field induced capacitance enhancement in graphene and magnetic graphene nanocomposites (2012)

Magnetic graphene nanocomposites (MGNCs) synthesized by a facile thermal decomposition method have been introduced. TEM observations reveal a uniform distribution of the Fe2O3 nanoparticle size and preferential nuclei growth along the edge defects. Both graphene and its Fe2O3 nanocomposites are prepared as electrochemical electrodes to evaluate their capacitor performances. Under normal conditions (without a magnetic field), the MGNCs show lower capacitance than graphene due to the large particle loading (52.5 wt%), which brings larger internal resistance and thus prevents efficient electron transportation within the electrodes. However, in the presence of an external magnetic field, both graphene and MGNC electrodes exhibit significantly enhanced capacitance as compared to the results obtained under normal conditions. Specifically, the capacitance of graphene is increased by 67.1 and 26.8% at the sweeping rates of 2 and 10 mV s−1, respectively. Even larger enhancements of 154.6 and 98.2% were observed in MGNCs at the same sweeping rates of 2 and 10 mV s−1, respectively. The energy density and power density of the electroactive materials are also dramatically enhanced in the presence of a magnetic field. Equivalent circuit modeling of impedance spectra revealed that the magnetic field played a critical role in restricting the interfacial relaxation process and thus enhanced the electrode capacitance. These findings present a potential revolution of traditional electrochemical capacitors by simply applying an external magnetic field to enhance the capacitance dramatically (even doubling it depending on the electroactive materials) without material replacement and structural modification.
Catalysis opportunities of atomically precise gold nanoclusters (2011)

Nanogold has been found to be an effective catalyst for many chemical reactions. However, mechanistic studies have thus far only met with limited success, largely due to the unavailability of well-defined catalysts. We are motivated to create atomically precise gold (Au) nanoclusters in the hope of unraveling some fundamental aspects of nanogold catalysis. In this feature article, we summarize recent works on the catalytic promise of a new class of materials: ultrasmall (<2 nm), semiconducting Au nanoclusters protected by thiolates, referred to as Aun(SR)m, where n and m represent the number of gold atoms and thiolate ligands, respectively. The recent research is focused on the synthesis and structural determination of atomically precise Aun(SR)m nanoclusters as well as exploring their catalytic properties. The correlation of the X-ray crystal structures of the Aun(SR)m nanoclusters with their catalytic properties will ultimately permit a deep understanding of the origin of nanogold catalysis and will also benefit the future design of new catalysts with high selectivity and activity.
Local positioning with passive UHF RFID transponders (2009)

This paper describes the theory of distance measurements with passive UHF transponders using the principle of modulated backscattering. The method was evaluated with the analogue frontend of a passive RFID chip for the UHF range. The chip was designed in a 0.14mum CMOS technology.
A general synthesis of arylindoles and (1-arylvinyl)carbazoles via a one-pot reaction from N-tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer (2016)

A convergent and effective synthesis of 3-aryl-indoles, 2,3-diaryl indoles, and (1-arylvinyl)carbazoles from a one-pot sequence involving the coupling of N-tosylhydrazones with ortho-nitro-haloarenes followed by a cyclization has been developed. Compound 5i exhibits excellent antiproliferative activity in the low nM range against colon cancer cell lines.
The mechanical properties of natural materials. I. Material property charts (1995)

Abstract The mechanical properties of natural materials as diverse as wood, muscle, shell and bone are plotted on material-property charts which show the relationships between properties. Performance indices are used to identify the load-bearing applications in which each performs particularly well. By these criteria, many natural materials are superior to the man-made materials of engineering. A companion paper examines some of the origins of this superiority; an explanation is sought in an analysis of the way structure influences properties.
Toward enhanced wireless coexistence in ISM band via temporal characterization and modelling of 802.11b/g/n networks (2016)

Abstract This paper presents extensive experimental characterization and empirical modelling of 802.11 temporal behavior. A detailed characterization of 802.11b/g/n homogeneous and heterogeneous network traffic patterns is featured, including idle time distribution and channel utilization. A complete modelling of 802.11 networks in the 2.4 GHz Industrial, Scientific, and Medical band is also presented. Such information can assist the development of other wireless technologies aiming to utilize the crowded Industrial, Scientific, and Medical band more efficiently and to achieve enhanced wireless coexistence. In this work, models are derived for both homogeneous and heterogeneous 802.11 network idle time distributions. Also presented is a case study utilizing 802.15.4 ZigBee transmitter packet size that was adaptively modified based on channel idle time distribution. Results demonstrate superior ZigBee performance and significant enhancement in throughput. Copyright © 2016 John Wiley & Sons, Ltd.
Spectral analysis of cardiovascular time series by the S-transform (2002)

This paper proposes the S transform (ST) as a method for spectral analysis of cardiovascular time series. The ST is an extension of wavelets: it uses an analysis window whose width decreases with frequency thus providing a frequency dependent resolution (constant Q). This allows one to overcome the drawbacks of the short time Fourier transform (STFT) in analyzing nonstationary time series like the cardiovascular series as obtained during diagnostic manoeuvres which change the status of the autonomic nervous system (ANS). The ST maintains a link with the Fourier analysis since its average over time provides the Fourier spectrum. Moreover, it is a linear transform and it provides frequency representation without cross-terms. An evaluation of the ST characteristics was performed by comparison with STFT, evolutionary periodogram and Wigner Ville transform in analyzing specific non-stationary synthetic signals. The method was applied to real cardiovascular time series, like heart rate and systolic pressure, as obtained by patients submitted for autonomic tests; the results showed high time resolution at respiratory frequency allowing the detection of short high frequency components; moreover, the good frequency resolution at low frequency allows one to discriminate specific components related to low rate respiratory activity from other low frequency oscillations.
American Board of Orthopaedic Surgery Practice of the Orthopaedic Surgeon: Part-II, Certification Examination Case Mix (2006)

The American Board of Orthopaedic Surgery (ABOS) is one of the twenty-four separate boards that make up the American Board of Medical Specialties. Of the twenty-four boards, fourteen require an oral examination. At present, the ABOS is the only board with a computerized data collection system that allows for the analysis of the collected information in the database.

The ABOS exists to serve the interests of the public and the medical profession by establishing educational standards for orthopaedic residents and by evaluating the initial and continuing qualifications and competence of orthopaedic surgeons. Upon completion of an approved residency program, applicants for board certification must pass a comprehensive, proctored written examination (the Part-I examination). Applicants must then practice orthopaedics for twenty-two months, twelve of which must be in one location. Many elect to begin the practice requirement following a fellowship. The applicants must then satisfactorily complete a thorough credentialing process and pass an oral examination (the Part-II examination) that is based on all of the candidate's operative cases in six consecutive months beginning one year before the oral examination.

Before 1998, candidates submitted individual case lists on paper. Beginning in July 1998, candidate case lists were collected as part of a nationwide orthopaedic database as a way of organizing the case lists for review and case selection for oral examination. The computerized lists can be analyzed for the entire candidate group or subgroups. This yields a comprehensive dataset of approximately 700 candidates per year.

Candidates for certification enter all operative procedures performed in six consecutive months in the year prior to examination. The candidate's case lists are verified from each hospital or surgical center during the six-month period. The case list from each hospital or surgical center must be notarized by the director of medical records. The ABOS has contracted with …