gebhart/patrepeval huggingface dataset:
Introduction: Optimizing Treatment Outcome in Depression (2000)

M orders. Antidepressant drugs have become first-line treatment for depression in both primary and s ecialty care settings. Despite the improved safety and tolerability of newer antidepressants compared with tricyclic antidepressants and monoamine oxidase inhibitors, many patients do not adhere to antidepressant treatment. What are the most important contributing factors to noncompliance with drug treatment in depression, and how can we approach this issue with our patients? In this supplement, based on a symposium held at the 1999 annual meeting of the American Psychiatric Association, Pedro L. Delgado, M.D., reviews some of these factors, focusing particularly on widely held misconceptions about depressive illness and antidepressants, misconceptions that may compromise treatment compliance. Steps for enhancing treatment adherence by improving patient and family education and communication between patients and clinicians are also presented. Additionally, Dr. Delgado discusses some of the more practical aspects of patient management leading to the development of a collaborative treatment environment. Unfortunately, even when patients adhere fully to antidepressant treatment, the robust efficacy of antidepressants fails to translate to universal response. Patients may improve minimally or not at all, despite adequate doses of antidepressants prescribed for an adequate period of time. Other patients may improve significantly, but their response may be only partial, with some symptoms persisting. In both scenarios, clinicians face the dilemma of what to do next. Several treatment strategies are available to help partial and nonresponders gain full therapeutic response. As my contribution to this supplement, I review the switching strategy, which is very widely used among clinicians for the management of nonresponse in depression. This strategy, in which the patient’s antidepressant is discontinued and a different one is started, is also frequently used in the management of intolerance. Although studies have shown that intolerance to one antidepressant does not predict intolerance to another antidepressant of the same class, many clinicians favor the switch to an antidepressant of a different class owing to concerns about possible cross-reactivity. As I point out in my review of the literature, switching antidepressants appears to be a relatively well-tolerated and effective strategy. More studies, however, are needed to guide clinicians in decisions concerning the type of switches (switch within the same class versus switch to a different class) and the specific agents involved. J. Craig Nelson, M.D., examines the efficacy of another widely used strategy, augmentation. This approach typically targets nonresponders and, in particular, partial responders to antidepressant treatment. A number of augmenting agents, such as lithium, have been used over the past few decades with relative success. However, the introduction of newer agents
Speaker and Noise Factorization for Robust Speech Recognition (2012)

Speech recognition systems need to operate in a wide range of conditions. Thus they should be robust to extrinsic variability caused by various acoustic factors, for example speaker differences, transmission channel and background noise. For many scenarios, multiple factors simultaneously impact the underlying “clean” speech signal. This paper examines techniques to handle both speaker and background noise differences. An acoustic factorization approach is adopted. Here, separate transforms are assigned to represent the speaker [maximum-likelihood linear regression (MLLR)], and noise and channel [model-based vector Taylor series (VTS)] factors. This is a highly flexible framework compared to the standard approaches of modeling the combined impact of both speaker and noise factors. For example factorization allows the speaker characteristics obtained in one noise condition to be applied to a different environment. To obtain this factorization modified versions of MLLR and VTS training and application are derived. The proposed scheme is evaluated for both adaptation and factorization on the AURORA4 data.
Paper-Based Microfluidic Electrochemical Immunodevice Integrated with Nanobioprobes onto Graphene Film for Ultrasensitive Multiplexed Detection of Cancer Biomarkers (2013)

To the best of our knowledge, this was the first report on the integration of a signal amplification strategy into a microfluidic paper-based electrochemical immunodevice for the multiplexed measurement of cancer biomarkers. Signal amplification was achieved through the use of graphene to modify the immunodevice surface to accelerate the electron transfer and the use of silica nanoparticles as a tracing tag to label the signal antibodies. Accurate, rapid, simple, and inexpensive point-of-care electrochemical immunoassays were demonstrated using a photoresist-patterned microfluidic paper-based analytical device (μPAD). Using the horseradish peroxidase (HRP)-O-phenylenediamine-H2O2 electrochemical detection system, the potential clinical applicability of this immunodevice was demonstrated through its ability to identify four candidate cancer biomarkers in serum samples from cancer patients. The novel signal-amplified strategy proposed in this report greatly enhanced the sensitivity of the detection of cancer biomarkers. In addition, the electrochemical immunodevice exhibited good stability, reproducibility, and accuracy and thus had potential applications in clinical diagnostics.
Design, synthesis and pharmacological test of a quinoline based, nonpeptidic analogue of neurotensin(8–13) (1997)

The design, synthesis and pharmacological testing of a quinoline based, nonpeptidic analogue of neurotensin(8–13) using our reported multiple template approach to developing nonpeptidic mimetics of neuropeptides are reported. The newly synthesized quinoline analogue is found to be less active in binding to the neurotensin receptors than previously reported mimetics-1 and -2 which are partial nonpeptidic analogues of neurotensin(8–13). However, the present study led to the discovery of a mistake in a literature procedure for alkylation at position-3 of ethyl indole-2-carboxylate and a consequent mistake in the synthesis of mimics-1 and -2. With the computational and experimental results of the quinoline analogue, along with mimics-1 and -2 with the correct structures, which, accordingly, served as a blind test for the multiple template approach, the concept of this approach has been experimentally validated.
Biomass production, essential oil yield and composition ofMyrica gale L. harvested from wild populations in Scotland and Finland (1998)

Myrica gale L. was harvested from wild populations in Scotland and Finland. Above-ground vegetation was assessed for growth and potential yield of biomass. Essential oil yield and composition were measured: leaf oil yield was 0.05–0.29%, flower oil yield 0.97%. Main components were α-pinene [20.1–38.9%], 1,8-cineole [2.5–23.9%], germacrene [0.4–13.2%] and γ-cadinene [8.4–21.0]. The essential oil has a potential use as a midge repellent. Copyright © 1998 John Wiley & Sons, Ltd.
Design for RMS/LCC the development of a design model (1999)

This paper presents the results of a Ph.D. project aimed to develop and implement a model (called SMARD) for the incorporation of reliability, availability, maintainability, supportability and life-cycle cost (RMS/LCC) aspects in the design and development process of large-scale, complex technical systems. Emphasis lies on the design and development processes related to one-of-a-kind chemical process plants, small to medium series aircraft, and mass production automotive industry. The SMARD model is developed based on several case studies conducted in Europe within these three branches of industry. Within a systems engineering approach the upfront attention towards RMS/LCC will lead to faster, more affordable design, production or manufacturing, operation and support of high-quality systems that satisfy all customer requirements.
Active Amphotericin B Derivatives Position the Mycosamine in Two Radial Orientations (2010)

Inward-looking: An amphotericin B probe is used to ascertain the orientation of the molecule in the membrane. Release of the fluorescein moiety shows that at least some of the mycosamine is oriented towards intracellular space.
Sound Field Synthesis Toolbox 2.1.0 (2016)

The Sound Field Synthesis Toolbox (SFS) for Matlab/Octave gives you the possibility to play around with sound field synthesis methods like Wave Field Synthesis (WFS) or near-field compensated Higher Order Ambisonics (NFC-HOA). There are functions to simulate monochromatic sound fields for different secondary source (loudspeaker) setups, time snapshots of full band impulses emitted by the secondary source distributions, or even generate Binaural Room Scanning (BRS) stimuli sets in order to simulate WFS with the SoundScape Renderer (SSR). For more information, see: http://matlab.sfstoolbox.org
Templated Fabrication of Periodic Metallic Nanopyramid Arrays (2007)

This paper reports a simple self-assembly-based templating approach for fabricating wafer-scale, periodic metallic nanopyramid arrays with nanoscale tips and high tip density (6 × 108 tips cm-2). Spin-coated, non-close-packed monolayer colloidal crystals are used as templates to create chromium nanohole arrays, which are utilized as etching masks to fabricate inverted silicon pyramidal pits by anisotropic KOH etching. Wafer-scale metallic pyramid arrays with sharp nanotips can then be replicated from silicon templates by a simple adhesive peeling process. This nonlithographic technique combines the simplicity and cost benefits of bottom-up self-assembly with the scalability and compatibility of standard top-down microfabrication in creating periodic metallic nanostructures that are not easily available by conventional nanofabrication. The resulting nanopyramid arrays show stable surface enhancements for Raman scattering from benzenethiol molecules adsorbed at the metal surfaces, even though these sputtered films are not rough.
Somatomedin-C Synergizes with Follicle-Stimulating Hormone in the Acquisition of Progestin Biosynthetic Capacity by Cultured Rat Granulosa Cells* (1985)

We have recently shown that nanomolar concentrations of somatomedin-C (Sm-C), are capable of enhancing the FSH-mediated (but not basal) accumulation of progesterone (Po) by cultured rat granulosa cells. To further characterize this direct cytodifferentiative effect of Sm-C, granulosa cells from immature, hypophysectomized, diethylstilbestrol-treated rats were cultured under serum-free conditions for up to 96 h. Concurrent treatment with highly purified Sm-C (50 ng/ml) produced 10.2- and 3.6-fold increments in the FSH (20 ng/ml)-stimulated accumulation of Po and 20 alpha-hydroxy-4-pregnen-3-one, respectively. Sm-C-augmented Po biosynthesis was dose- and time dependent, but was independent of the FSH dose employed. Significantly, this effect of Sm-C could not be accounted for by enhancement of cellular viability or plating efficiency, nor by an increase in the number of cells, or their DNA synthesis. Furthermore, specific inhibition of DNA synthesis with cytosine-1-beta-D-arabinofuranoside was without significant effect on the ability of SM-C to enhance FSH-supported Po biosynthesis. Insulin, like Sm-C, also synergized with FSH in the induction of Po biosynthesis. However, insulin [ED50 = 19.2 +/- 1.6 (SE) micrograms/ml] was approximately 4800-fold less potent than Sm-C [ED50 = 4.0 +/- 0.3 (SE) ng/ml] in this regard, and exerted little or no effect at concentrations presumed to saturate the putative high affinity granulosa cell insulin receptor. Although maximal stimulatory doses of Sm-C (75 ng/ml) or insulin (100 micrograms/ml) produced comparable increments in FSH-supported Po biosynthesis, combined treatment with maximal doses of both peptides did not prove additive. Pertinently, the direct cytodifferentiative effect of Sm-C is exerted at (nanomolar) concentrations compatible with its receptor-binding affinity as observed in all other cell types studied. Thus, Sm-C is not likely to be acting through the putative high affinity insulin receptor but rather through its own high affinity recognition sites. Similarly, the cytodifferentiative action of high dose insulin may reflect the consequences of its cross-interaction with the putative Sm-C, rather than the insulin receptor. These findings are in keeping with the suggestion that the granulosa cell may be the site of Sm-C reception and action and that Sm-C of intraovarian or circulatory origin may participate in the differentiation, as well as replication, of the developing granulosa cell.
Variable Step Size (VSS) control for Circular Leaky Normalized Least Mean Square (CLNLMS) algorithm used in AEC (2008)

A variable step size (VSS) learning rate control algorithm based on echo leakage factor is proposed for controlling the adaptation of time-domain ldquocircular leaky normalized least-mean squarerdquo (CLNLMS) algorithm used in acoustic echo cancellation (AEC). The proposed control algorithm provides higher step size during initial convergence to speedup the convergence rate and reduces the step size slowly towards an optimal value for least misadjustment. The proposed VSS-CLNLMS and other additional components required for an acoustic echo cancellation (AEC) for hands free IPPhone running on desktop PC is designed in fixed point C and tested in real time environment. The proposed methods provides considerable improvement in steady state echo cancellation as well as stability under false or delay in nearend signal detection by double talk detector (DTD). The additional complexity requirement for the new adaptation control algorithm is marginal. The implementation of step size estimation of standard VSS-CLNMS consumes about 4.12 MHz on a Pentium Processor with Windows XP/2000/NT for 8 kHz sampling rate and filter order of 1024, where as the proposed method consumes about 4.8 MHz. Similar performance can be expected when implemented and executed on other targeted platforms.
4. Les exemples dans le discours grammairien de l’âge classique : un cas de fonctionnement discursif de l’autonymie (2004)

Je propose dans cette contribution d’examiner certaines des caractéristiques des exemples dans un corpus de grammaires écrites aux XVIIe et XVIIIe siècles. Ce qui frappe dès l’abord, c’est la grande variété des formes que prend l’articulation de l’exemple et de son contexte. Cette variété tend à se réduire au cours du XVIIIe siècle, elle constitue néanmoins une donnée historique remarquable, dont je vais ici esquisser la description et proposer une interprétation. Donner des exemples suscepti...
Enhanced Sensitivity in Humidity Sensors based on Long Period Fiber Gratings (2006)

In this work a new relative humidity sensor based on the deposition of a subwavelength thickness overlay of alumina (Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ) and poly(Sodium 4-StyreneSulfonate) (PSS) on the cladding of a Long-Period Fiber Grating (LPFG) is presented. This material has a lower refractive index compared to the refractive index of the optical fiber. This characteristic limits the sensitivity of the sensor. In order to enhance the sensitivity to humidity it has been intercalated a high refractive index layer, which permits to improve the sensitivity of LPFG sensors by a ratio of four. The method proposed here widens the design of LPFG based sensors characterized by overlays of low refractive index, and could be used for other applications such as the design of optical filters.
<title>AirJet paper mover: an example of mesoscale MEMS</title> (2000)

The motion of human scale objects requires MEMS-like device arrays capable of providing reasonable forces ($GTR mN) over human scale distances (10-100 cm). In principle batch fabricated values controlling air jets can satisfy these actuation requirements. By extending printed circuit board technology to include electromechanical actuation, analogous to the extension of VLSI to MEMS, the requirement of low system cost can be achieved through batch fabrication and integration of the transduction elements with computational and communication elements. In this paper we show that modulated air jets arrayed with position sensors can support and accelerate flexible media without physical contact. Precise motion control with three degrees of freedom parallel to the array, using high flow, low pressure air jet arrays is enabled using electrostatic valves having opening and closing times of approximately equals 1 ms. We present results of an exemplary platform based on printed circuit board technologies, having an array of 576 electrostatic flap valvves (1152 for double-sided actuation) and associated oriented jets, and an integrated array of 32,000 optical sensors for high resolution detection of paper edge positions. Under closed loop control edge positioning has a standard deviation of approximately equals 25 microns. Fabrication and control of the system is described.
Preparation of methyl methacrylate and glycidyl methacrylate copolymerized nonporous particles (1999)

Particles of methyl methacrylate (MMA) and glycidyl methacrylate (GMA) copolymer having narrow size distributions were prepared by the method of dispersion polymerization. Results from the analysis of particle porosity and the correlation of specific surface area with the reciprocal of particle diameter suggest that the prepared particles were nonporous. The particle size was found to decrease from 4.2 to 2.1 μm with increasing the mass ratio of GMA/MMA from 0.1 to 0.75. Polymer particles having an average diameter falling in this range are suitable for being employed as the stationary phase in protein chromatography. The decrease in particle size when GMA was present could be due to the increase in adsorption rate of poly(vinyl pyrrolidone). The oligomer chains that were rich in GMA were more active for adsorbing and grafting PVP, compared with the moiety of MMA. An increase in the GMA/MMA ratio also leaded to a decrease in epoxy-group density on the particle surface, since the reactivity of GMA was greater than that of MMA. Results of this work suggest that the influence of GMA/MMA mass ratio on the particle size and surface functionality of the nonporous particles was very significant. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 1457–1463, 1999
Development of a novel affinity chromatography resin for platform purification of bispecific antibodies with modified protein a binding avidity (2018)

There is strong interest in the production of bispecific monoclonal antibodies that can simultaneously bind two distinct targets or epitopes to achieve novel mechanisms of action and efficacy. Regeneron's bispecific technology, based upon a standard IgG, consists of a heterodimer of two different heavy chains, and a common light chain. Coexpression of two heavy chains leads to the formation of two parental IgG impurities, the removal of which is facilitated by a dipeptide substitution in the Fc portion of one of the heavy chains that ablates Fc Protein A binding. Therefore, the affinity capture (Protein A) step of the purification process must perform both bulk capture and high resolution of these mAb impurities, a task current commercially available resins are not designed for. Resolution can be further impaired by the ability of Protein A to bind some antibodies in the variable region of the heavy chain (V<sub>H</sub> ). This article details development of a novel Protein A resin. This resin combines an alkali stable ligand with a base matrix exhibiting excellent mass transfer properties to allow high capacity single step capture and resolution of bispecific antibodies (bsAbs) with high yields. The developed resin, named MabSelect SuRe™ pcc, is implemented in GMP production processes for several bsAbs. © 2018 The Authors Biotechnology Progress published by Wiley Periodicals, Inc. on behalf of American Institute of Chemical Engineers Biotechnol. Prog., 34:650-658, 2018.
Complications of Pelvic Lymphadenectomy in 1,380 Patients Undergoing Radical Retropubic Prostatectomy Between 1993 and 2006 (2008)

Pelvic lymphadenectomy is the cause of a relevant number of perioperative complications in patients undergoing radical retropubic prostatectomy. Lymphocele formation, and the associated re-interventions and thromboembolic sequelae account for by far the highest percent of these complications. In the current study lymphocele formation depended on the extent of pelvic lymphadenectomy, the number of lymph nodes removed and the operating surgeon.
Map location and nucleotide sequence of<i>korA</i>, a key regulatory gene of promiscuous ptasmid RK2 (1983)

From our earlier work, we know that the korA gene of broad host range plasmid RK2 is located within the 50.4'-56.4' region. By additional subcloning of this region, we have mapped korA to the segment between the HaeII site at 55.0' and the HincII site at 55.6'. The direction of korA transcription (55.6' to 55.1') was determined by two methods: (1) inactivation of korA expression signals and fusion of the structural gene to other promoters; and (2) hybridization analysis of korA-specific RNA's synthesized in vivo. We have determined the nucleotide sequence of the korA region. A potentially strong promoter overlaps the HincII site at 55.6', and there is a coding region which specifies the putative korA polypeptide. That this is the korA gene was supported by sequence analysis of Ba131-generated deletion mutants of korA. The sequence shows the korA product to be a small, basic polypeptide of 101 amino acids.
Effects of Na2S and (NH4)2S edge passivation treatments on the dark current-voltage characteristics of GaAs <i>p</i> <i>n</i> diodes (1988)

We have investigated the dark current-voltage characteristics of GaAs pn homojunctions whose surfaces have been passivated with Na2S and (NH4)2S chemical treatments. Reductions in 2kT perimeter recombination currents by a factor of 3.2 were obtained for the two treatments. A shunt leakage, observed at low forward bias for the Na2S treated devices, is virtually eliminated with the (NH4)2S treatment. It is also shown that even the high quality, large area (0.25 cm2) pn diodes used in this study are dominated by 2kT edge currents before passivation.