gebhart/patrepeval huggingface dataset:
Pristionchus pacificus: a well‐rounded nematode (2006)

Nematodes pervade Earth's biosphere and occupy innumerable ecological niches. The role of Caenorhabditis elegans as a model for developmental processes has encouraged us to cultivate a second nematode, Pristionchus pacificus, as a comparative counterpoint to address questions in development, behavior and ecology in nematode evolution. We hope that this endeavor, now more than a decade underway, will allow us to project findings onto other comparative models for biological processes. To this end, our laboratory has made an extensive genetic map and mutant screens to understand changes in developmental programs. Recently, we have been capitalizing on the whole genome sequence of P. pacificus to describe more thoroughly the molecular basis for these changes, as well as to better integrate our molecular knowledge with the biodiversity of Pristionchus species.
Implementing Manufacturing Message Specification services and protocol using ISO Development Environment (2002)

The Manufacturing Message Specification (MMS) is an OSI application layer standard designed to support messaging communications to and from programmable devices in a computer integrated manufacturing (CIM) environment. This paper describes how the ISO Development Environment (ISODE) can be employed to implement MMS. ISODE is a non-proprietary implementation of the upper layers of the OSI protocol suite. The experience should be useful to those contemplating using ISODE to implement OSI application entities and application programs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Development of Isothermal Forging of Titanium Centrifugal Compressor Impeller. (1973)

Abstract : SHOP PRACTICE, VALUE ENGINEERING*ISOTHERMAL FORGINGThe technology of isothermal forging of titanium has been successfully extended to the production of impeller forgings. A four-part nickel-base superalloy die set weighing approximately 2000 lb was made and used to produce ten Ti-6Al-4V alloy forgings. The ten forgings were 13 1/2 in. OD, had a plan area of 114 sq. in., weighed between 24 and 25 1/2 lb, and had 36 blades radially emanating from the hub. The blades were 0.160 in. thick at the thinnest portion and had depths ranging from 3/4 to 1/2 in. depending upon location. The thickness of the hub portion of the forging at the 13 1/2 in. OD was typically 0.210 in. Preform temperatures were typically 1750F and die temperatures 1600F. Press forging loads were usually 1000 tons, equivalent to 17 kpsi forging pressure. (Modified author abstract)
Efficacy of a water-cooled garment for auxiliary body cooling in heat (1998)

The efficacy of a water-cooled jacket for auxiliary body cooling was examined under a simulated hot environment. The personal garment comprised of a water re-circulating three-layered vest of cotton fabric lined with 2 mm diameter latex tubing and inter-spaced coating of rubberized solution. Four subjects wearing the water-cooled jacket were tested in the environment chamber (30, 35 and 40 degrees C DB, 50-60% RH, air velocity 0.3, 0.6 and 0.9 m/s, with corresponding average effective temperature of 26 +/- 2.3, 33 +/- 1.1 and 36 +/- 1.5 degrees C). The inlet water temperature was maintained at 10-12 degrees C, with flow rates of 2.6 +/- 0.3, 4.3 +/- 0.3 and 5.1 +/- 0.3 l/h). At 30 degrees C DB, variation in water flow had marginal effect on microclimate, while at higher temperatures (35 and 40 degrees C DB), the re-circulating cooled water had noticeable effects in lowering microclimate, trunk and other skin temperatures, and maintaining the body core within 36.7 +/- 0.2 to 37.5 +/- 0.2 degrees C, over 2 h exposure at 35 and 40 degrees C DB. The observation indicates that the water-cooled jacket provided auxiliary cooling to maintain comfortable microclimate, skin and body core temperatures. This enabled subjects to sustain comfortable heat balance over 2 h heat exposure without any noticeable heat strain.
Rescuing recombinant proteins by sequestration into the P22 VLP (2013)

Here we report the use of a self-assembling protein cage to sequester and solubilize recombinant proteins which are usually trafficked to insoluble inclusion bodies. Our results suggest that protein cages can be used as novel vehicles to rescue and produce soluble proteins that are otherwise difficult to obtain using conventional methods.
Light pruning on Toy Story 4 (2019)

Pixar films have recently seen drastically rising light counts via procedural generation, resulting in longer render times and slower interactive workflows. Here we present a fully automated, scalable, and error-free light pruning pipeline deployed on Toy Story 4 that reduces final render times by 15--50% in challenging cases, accelerates interactive lighting, and automates a previously manual and error-prone task.
Is The Black Male College Graduate becoming an Endangered Species? A Multi-Case Analysis of the Attrition of Black Males in Higher Education (2013)

The purpose of this study was to examine how some black college students survived the phenomenon of low graduation rates, also known as attrition, occurring among black male students attending colleges in the state of California. Current research indicated that this phenomenon is a nationwide issue. The gap between black male college students and none-minority college students is significant and an indication of either discriminatory practices or inefficiencies within the system. This multiple case study involved a series of semi-structured interviews and field observation over a three month time-frame. The data was coded and triangulated. The findings pointed to several psycho-social factors that supported our framework of Social Network Theory and Resiliency Theory.
Side effects due to treatment of hypertension with prazosin. (1975)

completely healthy, without neurological symptoms or Kayser-Fleischer ring, and liver test results were normal.Serum caeruloplasmin1 was slightly decreased at 95 mg/l (normal value in our laboratory 130-270 mg/l), and urine copper excretion was raised at 1-27 1Lmol/24th (81 gg/24 h) (normal value 0-78 Lmol/24 h (50 sg/24 h)).After a diagnostic test with 64Cu2 a preclinical stage of Wilson's disease was diagnosed.He was given D-penicillamine 1 g/day.No side effects were observed during the first 13 months.In May 1973 he developed weakness of the right ocular muscles; in particular, ptosis was more pronounced at the end of the day.During the next 10 days the weakness became worse and left ptosis developed; no other muscles showed weakness.After edrophonium chloride 10 mg intravenously rapid opening of both eyes was noted.Electromyography and immunological investigations were not performed.Penicillamine was withdrawn and he was given neostigmine.After six weeks he showed no symptoms of myasthenia.Eight months later he still had no neurological symptoms.Laboratory investigations confirmed the diagnosis of Wilson's disease.An electromyo- gram and a laminagram of the mediastinum were normal.Though weak antibodies to smooth muscles were detected in the serum by indirect immuno- fluorescence no antinuclear antibodies were found.The patient was again given D-penicillamine 0 75 g/day.During the next 10 months he had no side effects.Antibodies to smooth muscles were detected in May and June 1974 but not in November 1974.The myastlienic syndrome which developed in this patient was probably induced by penicillamine, just as other autoimmune syn- dromes have occurred after long-term treatment with this drug.3
Role of Rheology in Achieving Successful Concrete Performance (2017)

This article provides a basic introduction to concrete rheology, as well as some insight into how rheology can be applicable to concrete construction.
TLR-2–Activated B Cells Suppress <i>Helicobacter</i>-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells (2010)

B cells regulate autoimmune pathologies and chronic inflammatory conditions such as autoimmune encephalomyelitis and inflammatory bowel disease. The potential counterregulatory role of B cells in balancing pathogen-specific immune responses and the associated immunopathology is less well understood owing to the lack of appropriate persistent infection models. In this paper, we show that B cells have the ability to negatively regulate adaptive immune responses to bacterial pathogens. Using mouse models of infection with Helicobacter felis, a close relative of the human gastrointestinal pathogen H. pylori, we found that B cells activated by Helicobacter TLR-2 ligands induce IL-10-producing CD4(+)CD25(+) T regulatory-1 (Tr-1)-like cells in vitro and in vivo. Tr-1 conversion depends on TCR signaling and a direct T-/B-interaction through CD40/CD40L and CD80/CD28. B cell-induced Tr-1 cells acquire suppressive activity in vitro and suppress excessive gastric Helicobacter-associated immunopathology in vivo. Adoptive cotransfer of MyD88-proficient B cells and Tr-1 cells restores a normal gastric mucosal architecture in MyD88(-/-) and IL-10(-/-) mice in a manner that depends on T cellular, but not B cellular, IL-10 production. Our findings describe a novel mechanism of B cell-dependent Tr-1 cell generation and function in a clinically relevant disease model. In conclusion, we demonstrate that the B cell/Tr-1 cell axis is essential for balancing the control of Helicobacter infection with the prevention of excessive Th1-driven gastric immunopathology, promoting gastric mucosal homeostasis on the one hand and facilitating Helicobacter persistence on the other.
Automatic generation of natural language descriptions for images (2004)

For some women, times of reproductive transition represent times of high risk for the onset or exacerbation of depressive symptoms. In order to maintain emotional stability, the female brain must adapt to fluctuations in hormones that affect neurotransmitter functioning. Difficulty with this adaptation, along with stresses related to social role transitions, may confer heightened vulnerability to depression. In this review, we summarize data regarding the course, expression and risks of depression and related symptoms during puberty and menarche, the luteal phase of the menstrual cycle, the perinatal period and perimenopause. We note treatment strategies that have been found to be effective for depressive symptoms during specific phases of the female reproductive cycle.
Injectable in situ Physically and Chemically Crosslinkable Gellan Hydrogel (2012)

Abstract An injectable, in situ physically and chemically crosslinkable gellan hydrogel is synthesized via gellan thiolation. The thiolation does not alter the gellan's unique 3‐D conformation, but leads to a lower phase transition temperature under physiological conditions and stable chemical crosslinking. The synthesis and hydrogels are characterized by 1 H NMR, FT‐IR, CD, or rheology measurements. The injectability and the tissue culture cell viability is also tested. The thiolated gellan hydrogel exhibits merits, such as ease for injection, quick gelation, lower gelling temperature, stable structure, and nontoxicity, which make it promising in biomedicine and bioengineering as an injectable hydrogel. magnified image
The Direct Synthesis of Hydrogen Peroxide from H2 and O2 over Au/TS-1 and Application in Oxidation of Thiophene in Situ (2006)

Abstract Au supported on TS-1 exhibits high activity in hydrogen peroxide formation from H2 and O2 under mild conditions (ambient temperature, low pressure about 1.5 MPa, water as solvent, 2 h); and thiophene dissolved in n-octane (as model gasoline) is oxidized in situ over Au/TS-1, about 82% removal of thiophene can be achieved.
Analysis on Seasonal Variation and Influencing Mechanism of Land Surface Thermal Environment: A Case Study of Chongqing (2022)

Rapid urbanization has brought about many problems in urban environments, including the deterioration of the thermal environment, which greatly affects the sustainable development of cities and the health of urban residents. Therefore, a comprehensive and thorough study of the thermal environment is necessary. In this study, quantitative and qualitative analyses of the interannual and seasonal variation of the thermal environment in the urban area of Chongqing were conducted using a combination of equal sector analysis, mathematical statistics, and principal component analysis. In addition, the mechanism by which multiple integrated human and natural factors affect the urban thermal environment in different seasons was explored. The thermal environment of the land surface has a clear spatial correlation with built-up areas. From 2010 to 2020, the Liangjiang New Area and the western high-tech zone were the main areas of thermal environment area expansion. From 2010 to 2020, a decrease in the area of low-temperature zones and an increase in the area of high-temperature zones were the main trends. In particular, during the summer of 2020, the low-temperature zones almost disappeared, and the area of high-temperature zones was nearly twice as large as in the other seasons. The combined influence of multiple factors on surface temperature has certain seasonal characteristics. The slope, elevation, normalized water body index, fractional vegetation cover, normalized imperviousness index, and nighttime light intensity were the main factors affecting the surface temperature, whereas landscape pattern indicators, as well as the population and points of interest (POI) density, had a low influence. The strength of the combined influence of these multiple factors of the different seasons exhibited the following order: winter > spring > summer > autumn.
Striking sequence similarity in inter- and intra-specific comparisons of class I <i>SLG</i> alleles from <i>Brassica oleracea</i> and <i>Brassica campestris</i> : Implications for the evolution and recognition mechanism (1997)

Self-incompatibility in Brassica is controlled by a single multi-allelic locus (S locus), which contains at least two highly polymorphic genes expressed in the stigma: an S glycoprotein gene (SLG) and an S receptor kinase gene (SRK). The putative ligand-binding domain of SRK exhibits high homology to the secretory protein SLG, and it is believed that SLG and SRK form an active receptor kinase complex with a self-pollen ligand, which leads to the rejection of self-pollen. Here, we report 31 novel SLG sequences of Brassica oleracea and Brassica campestris. Sequence comparisons of a large number of SLG alleles and SLG-related genes revealed the following points. (i) The striking sequence similarity observed in an inter-specific comparison (95.6% identity between SLG14 of B. oleracea and SLG25 of B. campestris in deduced amino acid sequence) suggests that SLG diversification predates speciation. (ii) A perfect match of the sequences in hypervariable regions, which are thought to determine S specificity in an intra-specific comparison (SLG8 and SLG46 of B. campestris) and the observation that the hypervariable regions of SLG and SRK of the same S haplotype were not necessarily highly similar suggests that SLG and SRK bind different sites of the pollen ligand and that they together determine S specificity. (iii) Comparison of the hypervariable regions of SLG alleles suggests that intragenic recombination, together with point mutations, has contributed to the generation of the high level of sequence variation in SLG alleles. Models for the evolution of SLG/SRK are presented.
Temperature Gradients Through EHD Films and Molecular Alignment Evidenced By Infrared Spectroscopy (1981)

Partial and complete emission band reversals have been observed in the infrared emission spectra from portions of operating sliding contacts. An elementary analysis has been carried out to show that partial reversals are due to temperature gradients in the fluid film—the film acts both as a radiation-emitter and absorber, and that total reversals—an emission spectrum appears as an absorption spectrum—are likely to be due to a continuum source, such as hot solid asperities. The total energy radiated under the latter conditions exceeds that under the others. A decrease in gap width with increased load was accompanied by a dramatic spectral change in the case of 5P4E polyphenyl ether, which is indicative of molecular alignment.
Anti-Epidermal Growth Factor Receptor Strategies to Enhance Radiation Action (2003)

The epidermal growth factor receptor (EGFR) has emerged as a central molecular target for modulation in cancer therapeutics, since EGFR signaling affects many factors that in turn promote tumor growth, progression and metastasis. In addition, radiobiological investigations have also defined a critical role for EGFR in mediating cytoprotective and pro-proliferative responses in human cancer cells after ionizing radiation, that contribute at least in part to accelerated tumor cell repopulation. This led to the additional development of EGFR as a target to enhance radiation efficacy. Several anti-EGFR strategies have been put forth demonstrating a favorable biological interaction between EGFR blockade and radiation. However, further preclinical investigations are necessary to better explore mechanisms of action and efficacy of combined treatment modalities. Although some of the anti-EGFR approaches have already reached clinical testing in combination with radiation, it is still too early to establish a clinical proof for the ultimate role of EGFR inhibition in combination with radiation. This article focuses primarily on anti-EGFR approaches to modulate radiation response.
Clinical Features and Metabolic and Autoimmune Derangements in Acquired Partial Lipodystrophy (2004)

We describe clinical features, body fat distribution, and prevalence of metabolic abnormalities in 35 patients with acquired partial lipodystrophy (APL) seen by us over 8 years, and also review 220 cases of APL described in the literature. Based on the review and our experience, we propose that the essential diagnostic criterion for APL is the gradual onset of bilaterally symmetrical loss of subcutaneous fat from the face, neck, upper extremities, thorax, and abdomen, in the "cephalocaudal" sequence, sparing the lower extremities. Analysis of the pooled data revealed that female patients were affected approximately 4 times more often than males. The median age of the onset of lipodystrophy was 7 years. Several autoimmune diseases, in particular systemic lupus erythematosus and dermatomyositis, were associated with APL. The prevalence rates of diabetes mellitus and impaired glucose tolerance were 6.7% and 8.9%, respectively. Approximately 83% of APL patients had low complement (C) 3 levels and the presence of polyclonal immunoglobulin C3 nephritic factor. Twenty-two percent of patients developed membranoproliferative glomerulonephritis (MPGN) after a median of approximately 8 years following the onset of lipodystrophy. Compared with patients without renal disease, those with MPGN had earlier age of onset of lipodystrophy (12.6 +/- 10.3 yr vs 7.7 +/- 4.4 yr, respectively; p < 0.001) and a higher prevalence of C3 hypocomplementemia (78% vs 95%, respectively; p = 0.02). The pathogenesis of fat loss and MPGN in patients with APL remains unclear, but activation of an alternate complement pathway has been implicated. Treating the cosmetic disfigurement by surgical procedures has yielded inconsistent results. The use of thiazolidinediones to treat fat loss in patients with APL remains anecdotal. Prognosis is mainly determined by renal insufficiency due to MPGN.
Identification of Bacteriophage MS2 Coat Protein from <i>E. coli</i> Lysates via Ion Trap Collisional Activation of Intact Protein Ions (2001)

Collisional activation of the intact MS2 viral capsid protein with subsequent ion/ion reactions has been used to identify the presence of this virus in E. coli lysates. Tandem ion trap mass spectrometry experiments on the +7, +8, and +9 charge states, followed by ion/ion reactions, provided the necessary sequence tag information (and molecular weight data) needed for protein identification via database searching. The most directly informative structural information is obtained from those charge states that produce a series of product ions arising from fragmentation at adjacent residues. The formation of these product ions via dissociation at adjacent amino acid residues depends greatly on the charge state of the parent ion. Database searching of the charge-state-specific sequence tags was performed by two different search engines: the ProteinInfo program from the Protein information Retrieval On-line World Wide Web Lab or PROWL and the TagIdent program from the ExPASy molecular biology server. These search engines were used in conjunction with the sequence tag information generated via collisional activation of the intact viral coat protein. These programs were used to evaluate the feasibility of generating sequence tags from collisional activation of intact multiply charged protein ions in a quadrupole ion trap.
Synthesis and Stability Region of Stoichiometric Nanocrystalline Vanadium−Iron Spinel Powders (2000)

Vanadium−iron spinels with nanometric sizes have been synthesized by a soft chemistry route. This way of elaboration consists of a coprecipitation followed by thermal treatments at low temperatures. The last thermal annealing is performed under a reducing atmosphere in order to obtain the exact oxygen stoichiometry (four oxygen atoms for three metal atoms in AB2O4). Because of the low temperatures used, very low oxygen partial pressures (between 10-20 and 10-30 Pa) have to be applied. For this purpose, a reducing setup has been used. It consists of H2/N2/H2O gas mixtures, creating a reducing atmosphere with low oxygen partial pressure. This atmosphere can be applied to a sample in a thermobalance, so the mass variations are correlated with the oxygen content (or oxygen stoichiometry) in the sample. Thermal annealing under low oxygen partial pressure allows one to obtain stoichiometric spinels of Fe3-xVxO4 (0 ≤ x ≤ 2).
Micromechanical properties of silicon-carbide thin films deposited using single-source chemical-vapor deposition (2001)

1,3-Disilabutane is used as a single-source precursor to deposit conformal silicon-carbide films on silicon atomic-force-microscopy cantilevers. By measuring the resonance frequency of the cantilever as a function of silicon-carbide film thickness and developing an appropriate model, the value of the film’s elastic modulus is determined. This value is in good agreement with those reported for silicon-carbide films deposited using conventional dual-source chemical-vapor deposition. Additionally, we comment on the feasibility of integrating this process into the fabrication technology for microelectromechanical systems.
Multiple roles of cytochrome <i>c</i> oxidase in mammalian cells under action of red and IR‐A radiation (2010)

This article reviews the current knowledge in photobiology and photomedicine about the influence of monochromatic, quasimonochromatic, and bread-band radiation of red-to-near infrared (IR-A) part on solar spectrum upon mammalian cells and human skin. The role of cytochrome c oxidase as the photoacceptor and photosignal transducer is underlined and its photosensitivity at certain circumstances is discussed. The role of ATP as a critical signaling molecule is discussed.