gebhart/patrepeval huggingface dataset:
Coronary atherosclerosis and interventions: Pathological sequences and restenosis (1999)

The primary cause of cardiac morbidity and mortality in developed countries is ischemic (coronary) heart disease. The incidence of this disease is virtually all due to atherosclerosis, and ischemic heart disease is also the most prevalent disease in the industrialized world, causing over 40% of all deaths in the United States and Western Europe. In Japan, the incidence of ischemic heart disease due to coronary atherosclerosis is gradually increasing as well. Compared with the classical nomenclature of atherosclerosis; that is, fatty streak, fibrous plaque and complicated lesions, the term Stary's classification has been universally accepted because it reflects the more recently acquired knowledge about the morphological and biochemical details of the processes in coronary atherosclerosis, which have been obtained by new strategies such as angioscopy, intravascular ultrasound and molecular biological methods. The term Stary's classification has been applied for the coronary atherosclerosis of patients with acute coronary syndrome at the National Cardiovascular Center, for the analysis of predisposing atherosclerosis of these patients. The recent findings regarding acute coronary syndrome resulting from a rupture of coronary atherosclerotic plaques indicate that this syndrome is probably the most important mechanism underlying the sudden onset. It has been found that the risk of plaque rupture may depend more on plaque composition than on plaque size. Plaques rich in soft extracellular lipids and macrophages are possibly more vulnerable to plaque rupture. Two of the goals of the present review are to clarify how plaque disruption occurs and to elucidate the relationship between plaque disruption and coronary risk factors in elderly Japanese patients with acute coronary syndrome. Coronary stents have been shown to be efficacious in the treatment of acute and threatened closure complicating percutaneous transluminal coronary angioplasty (PTCA) and have produced encouraging initial results in the prevention of restenosis. In the autopsy study of restenosis after PTCA, it was observed that dense caps of collagen fibers in the adventitia in the vicinity of the disrupted internal elastic laminae were present in all of the remodeling lesions. It is suggested that remodeling, which resulted in adventitial scarring, is one of the major causative factors of restenosis after PTCA. The long-term success of stenting, however, remains limited by the occurrence of late in-stent restenosis, with an incidence of 20-42% depending on the stent design and the patient population studied. Another aim of the present review is to describe the pathological mechanism of restenosis after PTCA and/or stent replacement and, consequently, the vascular remodeling that occurs around adventitial tissue after PTCA and intimal hyperplasia that is chronically irritated by a foreign body granulomatous reaction after stenting. Finally, the results of the investigation of the effect of a tissue factor pathway inhibitor on the prevention of interventional restenosis is described.
Fluorescent polymer-porous silicon microcavity devices for explosive detection (2007)

Conjugated polymers entrapped in porous silicon microcavity have been studied as optical sensors for low volatility explosives such as trinitrotoluene. The fluorescence spectra of entrapped polymers were modulated by the microcavity via a spectral “hole” that matches the resonance peak of the microcavity reflectance. Exposure of the porous silicon microcavity containing entrapped polymer to explosives vapor results in a red shift of the resonance peak and the spectral hole, accompanied by the quenching of the fluorescence. This multiplexed response provides multiple monitoring parameters, enabling the development of an optical sensor array for the detection of target explosive vapor.
VITS-a vision system for autonomous land vehicle navigation (1988)

A description is given of VITS (for vision task sequencer), the vision system for the autonomous land vehicle (ALV) Alvin, addressing in particular the task of road-following. The ALV vision system builds symbolic descriptions of road and obstacle boundaries using both video and range sensors. The authors discuss various road segmentation methods for video-based road-following, along with approaches to boundary extraction and transformation of boundaries in the image plane into a vehicle-centered three-dimensional scene model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Coherence Properties and L.F. Noise in AlGaAs Lasers with Optical Feedback (1986)

Experimental results are reported on the coherence properties and low frequency noise of index-guided AlGaAs diode lasers with optical feedback. The coherence length, Lc, of the laser field is strongly dependent on the amount of feedback and feedback phase, provided Lc is larger than twice the external cavity length. A coherence collapse is observed for high levels of op-tical feedback. Three excess noise peaks have been observed and are attributed to external cavity mode - and diode cavity mode hopping. The results will be discussed using a theoretical analysis for the nearly-coherent feedback and fully-incoherent feedback cases.
Small-Molecule Modulators of Listeria monocytogenes Biofilm Development (2011)

Listeria monocytogenes is an important food-borne pathogen whose ability to form disinfectant-tolerant biofilms on a variety of surfaces presents a food safety challenge for manufacturers of ready-to-eat products. We developed here a high-throughput biofilm assay for L. monocytogenes and, as a proof of principle, used it to screen an 80-compound protein kinase inhibitor library to identify molecules that perturb biofilm development. The screen yielded molecules toxic to multiple strains of Listeria at micromolar concentrations, as well as molecules that decreased (≤ 50% of vehicle control) or increased (≥ 200%) biofilm formation in a dose-dependent manner without affecting planktonic cell density. Toxic molecules-including the protein kinase C antagonist sphingosine-had antibiofilm activity at sub-MIC concentrations. Structure-activity studies of the biofilm inhibitory compound palmitoyl-d,l-carnitine showed that while Listeria biofilm formation was inhibited with a 50% inhibitory concentration of 5.85 ± 0.24 μM, d,l-carnitine had no effect, whereas palmitic acid had stimulatory effects. Saturated fatty acids between C(9:0) and C(14:0) were Listeria biofilm inhibitors, whereas fatty acids of C(16:0) or longer were stimulators, showing chain length specificity. De novo-synthesized short-chain acyl carnitines were less effective biofilm inhibitors than the palmitoyl forms. These molecules, whose activities against bacteria have not been previously established, are both useful probes of L. monocytogenes biology and promising leads for the further development of antibiofilm strategies.
Sedation in the intensive care setting (2012)

Critically ill patients are routinely provided analgesia and sedation to prevent pain and anxiety, permit invasive procedures, reduce stress and oxygen consumption, and improve synchrony with mechanical ventilation. Regional preferences, patient history, institutional bias, and individual patient and practitioner variability, however, create a wide discrepancy in the approach to sedation of critically ill patients. Untreated pain and agitation increase the sympathetic stress response, potentially leading to negative acute and long-term consequences. Oversedation, however, occurs commonly and is associated with worse clinical outcomes, including longer time on mechanical ventilation, prolonged stay in the intensive care unit, and increased brain dysfunction (delirium and coma). Modifying sedation delivery by incorporating analgesia and sedation protocols, targeted arousal goals, daily interruption of sedation, linked spontaneous awakening and breathing trials, and early mobilization of patients have all been associated with improvements in patient outcomes and should be incorporated into the clinical management of critically ill patients. To improve outcomes, including time on mechanical ventilation and development of acute brain dysfunction, conventional sedation paradigms should be altered by providing necessary analgesia, incorporating propofol or dexmedetomidine to reach arousal targets, and reducing benzodiazepine exposure.
Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: An in vitro study (2008)

A combined PDT and PTT treatment appears to be a more effective treatment strategy compared to conventional PDT or emerging PTT treatment.
Reduction of modal noise by using reduced spot excitation (1981)

The paper describes a computational model to estimate the reduction of nonlinear distortions due to a fiber-fiber joint by properly focusing the optical beam from a single transverse-mode semiconductor laser source to the input end of the first fiber. Mode mixing effects are included in the model. Material dispersion is found to make a negligible contribution in comparison with a typical source coherence time. In a typical situation, where the fiber joint coupling efficiency eta is better than 0.7, all harmonic distortion components produced in the joint could be reduced by ~10 dB by halving the input beam spot radius from the value equal to the fiber core radius.
[Comparative study of ixodes ticks on their infection with tularemia pathogen using biologic and serological assays]. (2004)

The paper presents the results of a long-term comparative study of the infection of Ixodes tick imagoes with the pathogen of tularemia by using the biological assay and antibody neutralization test. The infection rates determined by both methods were found to be identical or close. If there was a difference in the rates in some years, it was not statistically significant. A statistically significant difference could not be found in the infection rates for ticks and in the dependence on their species composition though the level of infection in representatives of one species greatly differed from that in others. The serological study of Ixodes tick imagoes, aimed at determining their infection with a tularemia pathogen, yielded the results which are comparable with those of the biological assay and may be used in epizootological studies without using the biological test or by significantly limiting its use.
Proof of Principle in a De novo Designed Protein Maquette:  An Allosterically Regulated, Charge-Activated Conformational Switch in a Tetra-α-Helix Bundle (2001)

New understanding of the engineering and allosteric regulation of natural protein conformational switches (such as those that couple chemical and ionic signals, mechanical force, and electro/chemical free energy for biochemical activation, catalysis, and motion) can be derived from simple de novo designed synthetic protein models (maquettes). We demonstrate proof of principle of both reversible switch action and allosteric regulation in a tetra-alpha-helical bundle protein composed of two identical di-helical subunits containing heme coordinated at a specific position close to the disulfide loop region. Individual bundles assume one of two switch states related by large-scale mechanical changes: a syn-topology (helices of the different subunits parallel) or anti-topology (helices antiparallel). Both the spectral properties of a coproporphyrin probe appended to the loop region and the distance-dependent redox interaction between the hemes identify the topologies. Beginning from a syn-topology, introduction of ferric heme in each subunit (either binding or redox change) shifts the topological balance by 25-50-fold (1.9-2.3 kcal/mol) to an anti-dominance. Charge repulsion between the two internal cationic ferric hemes drives the syn- to anti-switch, as demonstrated in two ways. When fixed in the syn-topology, the second ferric heme binding is 25-80-fold (1.9-2.6 kcal/mol) weaker than the first, and adjacent heme redox potentials are split by 80 mV (1.85 kcal/mol), values that energetically match the shift in topological balance. Allosteric and cooperative regulation of the switch by ionic strength exploits the shielded charge interactions between the two hemes and the exposed, cooperative interactions between the coproporphyrin carboxylates.
A three‐dimensional model of aromatase cytochrome P450 (1995)

P450 hemeproteins comprise a large gene superfamily that catalyzes monooxygenase reactions in the presence of a redox partner. Because the mammalian members are, without exception, membrane-bound proteins, they have resisted structure-function analysis by means of X-ray crystallographic methods. Among P450-catalyzed reactions, the aromatase reaction that catalyzes the conversion of C19 steroids to estrogens is one of the most complex and least understood. Thus, to better understand the reaction mechanism, we have constructed a three-dimensional model of P450arom not only to examine the active site and those residues potentially involved in catalysis, but to study other important structural features such as substrate recognition and redox-partner binding, which require examination of the entire molecule (excepting the putative membrane-spanning region). This model of P450arom was built based on a "core structure" identified from the structures of the soluble, bacterial P450s (P450cam, P450terp, and P450BM-P) rather than by molecular replacement, after which the less conserved elements and loops were added in a rational fashion. Minimization and dynamic simulations were used to optimize the model and the reasonableness of the structure was evaluated. From this model we have postulated a membrane-associated hydrophobic region of aliphatic and aromatic residues involved in substrate recognition, a redox-partner binding region that may be unique compared to other P450s, as well as residues involved in active site orientation of substrates and an inhibitor of P450arom, namely vorozole. We also have proposed a scheme for the reaction mechanism in which a "threonine switch" determines whether oxygen insertion into the substrate molecule involves an oxygen radical or a peroxide intermediate.
Testing Untyped Alleles (TUNA)—applications to genome‐wide association studies (2006)

Abstract The large number of tests performed in analyzing data from genome‐wide association studies has a large impact on the power of detecting risk variants, and analytic strategies specifying the optimal set of hypotheses to be tested are necessary. We propose a genome‐wide strategy that is based on one degree of freedom tests for all the genotyped variants, and for all the untyped variants for which there is sufficient information in the observed data. The set of untyped variants to be tested is found using multi‐locus measures of linkage disequilibrium and haplotype frequencies from a reference database such as HapMap (The International HapMap Consortium [2003] Nature 426:789–796). We introduce a novel statistic for testing differences in allele frequencies for untyped variation that is based on linear combinations of estimable haplotype frequencies. Algorithms for finding the sets of genotyped markers to be used in testing an untyped allele, and ways of incorporating haplotypes observed in the study data but not in the reference database are also described. The proposed testing strategy can be used as the first step in the analysis of genome‐wide association data, and, because every performed test is directed to a marker, it can be used to specify the set of polymorphisms to genotype in follow‐up studies. The described methodology provides also a tool for joint analysis of data from studies done on different platforms. Genet. Epidemiol. 2006.© 2006 Wiley‐Liss, Inc.
Synthesis of nanoporous three-dimensional current collector for high-performance lithium-ion batteries (2013)

We demonstrate the synthesis of Cu nanoporous three-dimensional current collector via a simple template-assisted method. Silicon, germanium and tin are selected as the anode materials to illustrate the enhanced performance. When tested as electrodes in lithium-ion batteries, they all show high reversible capacity with excellent rate performance. The three-dimensional nanostructure allows for good accommodation of the volume change and ensures a large surface area contact with active material and enhances the conductivity, which should be responsible for the enhanced performance.
Miniaturization of analytical techniques—lab on a chip (1998)

Journal Article Miniaturization of analytical techniques—lab on a chip Get access Andreas Manz Andreas Manz Zeneca/SmithKline Beecham Centre for Analytical Science, Department of Chemistry, Imperial College, London SW7 2AY Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 50, Issue Supplement_9, September 1998, Page 42, https://doi.org/10.1111/j.2042-7158.1998.tb02242.x Published: 12 April 2011
Medium-chain triglyceride supplementation under a low-carbohydrate formula is a promising therapy for adult-onset type II citrullinemia (2014)

An MCT supplement can provide energy to hepatocytes and promote hepatic lipogenesis, leading to a reduction in the cytosolic NADH/NAD<sup>+</sup> ratio. MCT supplementation under a low-carbohydrate formula could be a promising therapy for CTLN2 and should also be used to prevent CTLN2 to avoid irreversible liver damage.
Development of Moire machine vision (1987)

Three dimensional perception is essential to the development of versatile robotics systems in order to handle complex manufacturing tasks in future factories and in providing high accuracy measurements needed in flexible manufacturing and quality control. A program is described which will develop the potential of Moire techniques to provide this capability in vision systems and automated measurements, and demonstrate artificial intelligence (AI) techniques to take advantage of the strengths of Moire sensing. Moire techniques provide a means of optically manipulating the complex visual data in a three dimensional scene into a form which can be easily and quickly analyzed by computers. This type of optical data manipulation provides high productivity through integrated automation, producing a high quality product while reducing computer and mechanical manipulation requirements and thereby the cost and time of production. This nondestructive evaluation is developed to be able to make full field range measurement and three dimensional scene analysis.
Theory of quarter-wave-stack dielectric mirrors used in a thin Fabry-Perot filter (2003)

I present a new derivation of the analytic form for the phase shift near resonance and the optical penetration length upon reflection from a distributed dielectric mirror consisting of a quarter-wave stack. The requirement of proper termination to achieve high reflectivity is suspended to investigate large optical penetration depths. Separate equations, derived for N and N + 1/2 layer pairs, are convenient for the design of tunable Fabry-Perot filters with a specified tuning range. The analysis is also applicable to distributed Bragg reflectors, vertical-cavity surface-emitting lasers, and resonant photodiodes. I show that the penetration length can sharply reduce the overly broad free spectral range of an ultrathin Fabry-Perot filter that might be useful in applications such as tunable wavelength filters for wavelength division multiplexing applications. The results also demonstrate regimes of zero dispersion and of superluminal reflection in the dielectric mirrors, which are of particular interest in photonic bandgap structures.
New skin closure system facilitates wound healing after cardiovascular implantable electronic device surgery (2015)

The manuscript describes the efficacy of a new skin closure system (ZipLine) for wound closure after pacemaker/implantable cardioverter defibrillator surgery. The system is particularly useful when wound healing is difficult with traditional methods and in patients at high risk for surgical site infections (SSIs). This skin closure option is easy and quick to apply and remove, and produces excellent cosmetic results. Although it is associated with a minimal expense upcharge, the benefits, including the potential for decrease in SSI, make it attractive and worth considering for skin closure in device patients, particularly those at increased risk of complications.
Antivirals--current trends in fighting influenza. (2014)

Influenza virus infection is a major source of morbidity and mortality worldwide. Due to the variable effectiveness of existing vaccines, especially in the early stages of an epidemic, antiviral drugs represent the first line of defense against the virus. Currently, there are two major classes of anti-influenza drugs approved by the FDA for clinical use: M2 protein inhibitors (amantadine and rimantadine) and neuraminidase inhibitors (zanamivir and oseltamivir). However, increasing resistance to these available influenza antivirals among circulating influenza viruses highlights the need to develop alternative approaches for the prevention and/or treatment of influenza. This review presents an overview of currently available drugs for influenza treatment as well as summarizes some new antiviral strategies that are now being tested covering agents targeting both the viral proteins and the host-virus interaction. We discuss their mechanisms of action, resistance and the therapeutic potential as new antiviral drug for use in future influenza pandemics. Additionally, combination therapy based on these drugs is also described.
Rhythmic Activity in the Insect Nervous System (1971)

ABSTRACT Spiracle 1 of Sphodromantis lineola possesses a moveable valve equipped with two closer muscles which act as synergists, receive identical innervation but act on different regions of the valve. The two muscles are controlled by two motor axons which produce simultaneous small EPSPs in the two muscles of the left and right spiracles. Valve activity can be facultatively coupled to the abdominal ventilatory rhythm. Three patterns of coupling have been recognized. Ventilation-coupled activity includes burst formation. Similar repetitive bursts can be produced in the spiracle nerves of an isolated segment by treatment with CO2 and by mechanical stimulation.