gebhart/patrepeval huggingface dataset:
Synthesis of Silyl and Germyl Ketones (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Silyl and Germyl KetonesA. G. Brook, J. M. Duff, Peter F. Jones, and N. R. DavisCite this: J. Am. Chem. Soc. 1967, 89, 2, 431–434Publication Date (Print):January 1, 1967Publication History Published online1 May 2002Published inissue 1 January 1967https://pubs.acs.org/doi/10.1021/ja00978a047https://doi.org/10.1021/ja00978a047research-articleACS PublicationsRequest reuse permissionsArticle Views1009Altmetric-Citations190LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Si-based photodetectors in optical communication (2009)

Si-based photodetectors play key role in the performance of Si-photonic Devices. Design of high performance Si-detectors for optical communication system is a challenging task. Drawbacks arising from low absorption efficiency due to indirect nature of the band-gap in Si, strain in Ge/Si heterointerfaces, etc are to be overcome with suitable structure/design of the detectors. In this paper, a brief review is given on Si-detectors, such as Si-CMOS, SiGe and Ge-on-Si photodetectors including their fabrication techniques, performance trend with some aspects of modeling.
Effects of Bioabsorbable and Non‐Resorbable Barrier Membranes on Bone Augmentation in Rabbit Calvaria (1998)

The aim of this study was to compare the effects of bioabsorbable and non-resorbable membranes on experimental guided bone augmentation in 8 Japanese white rabbits. A cutaneous flap was demarcated and raised from the forehead of each animal, the periosteum was lifted, and the calvarial bone on both sides of the midline was exposed. A titanium screw was inserted into the bone on each side of the midline and one screw was covered with a bioabsorbable (polylactic acid) membrane and the other with a non-resorbable (expanded polytetrafluoroethylene) membrane. The implanted screws and membranes were then covered with the periosteum and cutaneous flap. After healing for 6 months, the animals were euthanized and the experimental area was prepared for histological investigation. New bone had formed under both membranes with no sign of infection or membrane exposure. The amount of newly generated bone (89.0 +/- 17.3% versus 54.7 +/- 14.0%, P <0.05) and the percentage of newly generated bone height (81.5 +/- 6.3% versus 58.9 +/- 7.8%, P <0.05) in the space beneath the non-resorbable membrane was greater than that beneath the bioabsorbable membrane. However, there were no statistically significant differences between the bioabsorbable and non-resorbable membranes with respect to the percentage areas of mineralized bone (52.3 +/- 11.3% versus 47.1 +/- 6.7%, P = 0.8658) and bone marrow (47.7 +/- 11.3% versus 52.9 +/- 6.7%, P = 0.4838) and bone contact with the screw (88.3 +/- 6.9% versus 89.2 +/- 7.3%, P = 0.9999). In conclusion, at least within the limitations of this rabbit model, we suggest that non-resorbable membranes with sufficient stiffness should be used to obtain greater bone volume and height instead of bioabsorbable membranes for the GBR procedure, and that this will facilitate predictable bone augmentation in spaces beyond the bone surface. Therefore, the bioabsorbable membrane could not replace the non-resorbable membrane used in this model.
Grafting BSA onto Poly[(<scp>L</scp>‐lactide)‐<i>co</i>‐carbonate] Microspheres by Click Chemistry (2008)

Model protein bovine serum albumin (BSA) was covalently grafted onto poly[(L-lactide)-co-carbonate] microsphere surfaces by "click chemistry." The grafting was confirmed by confocal laser scanning microscopy and X-ray photoelectron spectroscopy. The maximum amount of surface-grafted BSA was 45 mg x g(-1). The secondary structure of the grafted BSA was analyzed by FTIR and the results demonstrated that the grafting did not affect protein structure. This strategy can also be used on microspheres prepared from poly(L-lactide)/poly[(L-lactide)-co-carbonate] blend materials.
PROMOTER ACTION WITH OXIDE CATALYSTS FOR THE DECOMPOSITION OF ALCOHOLS<sup>1</sup> (1929)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPROMOTER ACTION WITH OXIDE CATALYSTS FOR THE DECOMPOSITION OF ALCOHOLS1Homer Adkins and Paul E. MillingtonCite this: J. Am. Chem. Soc. 1929, 51, 8, 2449–2460Publication Date (Print):August 1, 1929Publication History Published online1 May 2002Published inissue 1 August 1929https://pubs.acs.org/doi/10.1021/ja01383a027https://doi.org/10.1021/ja01383a027research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pulmonary Hypertension in Transgenic Mice Expressing a Dominant-Negative BMPRII Gene in Smooth Muscle (2004)

Bone morphogenetic peptides (BMPs), a family of cytokines critical to normal development, were recently implicated in the pathogenesis of familial pulmonary arterial hypertension. The type-II receptor (BMPRII) is required for recognition of all BMPs, and targeted deletion of BMPRII in mice results in fetal lethality before gastrulation. To overcome this limitation and study the role of BMP signaling in postnatal vascular disease, we constructed a smooth muscle-specific transgenic mouse expressing a dominant-negative BMPRII under control of the tetracycline gene switch (SM22-tet-BMPRII(delx4+) mice). When the mutation was activated after birth, mice developed increased pulmonary artery pressure, RV/LV+S ratio, and pulmonary arterial muscularization with no increase in systemic arterial pressure. Studies with SM22-tet-BMPRII(delx4+) mice support the hypothesis that loss of BMPRII signaling in smooth muscle is sufficient to produce the pulmonary hypertensive phenotype.
Selective agents for listeria can inhibit their growth (1989)

Journal Article Selective agents for listeria can inhibit their growth Get access G. D. W. Curtis, G. D. W. Curtis Bacteriology Department and Regional Public Health Laboratory, John Radcliffe Hospital, Oxford 0X3 9DU, UK Search for other works by this author on: Oxford Academic Google Scholar W. W. Nichols, W. W. Nichols Bacteriology Department and Regional Public Health Laboratory, John Radcliffe Hospital, Oxford 0X3 9DU, UK Search for other works by this author on: Oxford Academic Google Scholar T. J. Falla T. J. Falla Bacteriology Department and Regional Public Health Laboratory, John Radcliffe Hospital, Oxford 0X3 9DU, UK Search for other works by this author on: Oxford Academic Google Scholar Letters in Applied Microbiology, Volume 8, Issue 5, 1 May 1989, Pages 169–172, https://doi.org/10.1111/j.1472-765X.1989.tb00240.x Published: 01 May 1989 Article history Received: 27 January 1989 Accepted: 30 January 1989 Published: 01 May 1989
Advances in resist technology and processing XV : 23-25 February 1998, Santa Clara, California (1998)

A review of advances in resist technology and processing. It contains 142 papers which cover areas such as ArF materials, DUV processing and Novolak-based processing.
A simple potential-theory model for predicting mixed-gas adsorption (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA simple potential-theory model for predicting mixed-gas adsorptionS. J. Doong and R. T. YangCite this: Ind. Eng. Chem. Res. 1988, 27, 4, 630–635Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://doi.org/10.1021/ie00076a017Request reuse permissionsArticle Views314Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (656 KB) Get e-Alertsclose Get e-Alerts
Transcorneal Electrical Stimulation for Patients With Retinitis Pigmentosa: A Prospective, Randomized, Sham-Controlled Follow-up Study Over 1 Year (2017)

The safety and acceptable tolerability of weekly TES self-administered by patients at home was confirmed over the course of 1 year. Objectively measured improvements in retinal function with ERG provide support for the potential benefits of TES for RP patients.
Optimal Adapter Creation for Process Composition in Synchronous vs. Asynchronous Communication (2012)

A key issue in process-aware e-commerce collaboration is to orchestrate business processes of multiple business partners throughout a supply chain network in an automated and seamless way. Since each partner has its own internal processes with different control flow structures and message interfaces, the real challenge lies in verifying the correctness of process collaboration, and reconciling conflicts in an automated manner to make collaboration successful. The purpose of business process adaptation is to mediate the communication between independent processes to overcome their mismatches and incompatibilities. The goal of this article is to develop and compare efficient approaches of optimal adapter (i.e. one that minimizes the number of messages to be adapted) creation for multiple interacting processes under both synchronous and asynchronous communication. We start with an analysis of interactions of each message pair, and show how to identify incompatible cases and their adaptation elements for both types of communication. Then, we show how to extend this analysis into more general cases involving M messages and N processes ( M, N > 2). Further, we present optimal adapter creation algorithms for both scenarios based on our analysis technique. The algorithms were implemented in a Java-based prototype system, and results of two experiments are reported. We compare and discuss the insights gained about adapter creation in these two scenarios.
SQL Server 2016 Features (2016)

This chapter provides an overview of several new SQL Server 2016 features, such as temporal tables, stretch databases, row-level security, dynamic data masking, and Always Encrypted.
Type I interferon‐activated microglia are critical for neuromyelitis optica pathology (2020)

Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system (CNS) most frequently mediated by serum autoantibodies against the water channel aquaporin 4, expressed on CNS astrocytes, resulting in primary astrocytopathy. There is no cure for NMO, and treatment with Type I interferon (IFNI)-IFNβ is ineffective or even detrimental. We have previously shown that both NMO lesions and associated microglial activation were reduced in mice lacking the receptor for IFNβ. However, the role of microglia in NMO is not well understood. In this study, we clarify the pathomechanism for IFNI dependence of and the role of microglia in experimental NMO. Transcriptome analysis showed a strong IFNI footprint in affected CNS tissue as well as in microglial subpopulations. Treatment with IFNβ led to exacerbated pathology and further microglial activation as evidenced by expansion of a CD11c<sup>+</sup> subset of microglia. Importantly, depletion of microglia led to suppression of pathology and decrease of IFNI signature genes. Our data show a pro-pathologic role for IFNI-activated microglia in NMO and open new perspectives for microglia-targeted therapies.
Ion mobility-mass spectrometry applied to cyclic peptide analysis: conformational preferences of gramicidin S and linear analogs in the gas phase (2004)

In this paper, we present an investigation of the gas-phase structural differences between cyclic and linear peptide ions by matrix-assisted laser desorption ionization-ion mobility-mass spectrometry. Specifically, data is shown for gramicidin S (cyclo-VOLFPVOLFP where phenylalanines are D rather than L-type amino acids and the O designates the non-standard amino acid ornithine) and five linear gramicidin S analogues. Results are interpreted as evidence for a β-sheet (or β-hairpin) conformational preference in both linear-protonated and sodiated-cyclic gramicidin S gas-phase peptides, and a preference for the protonated-cyclic peptide to adopt a collapsed, random coil-type conformation. A comparison with solution-phase circular dicrhoism measurements is performed, and structures similar to those observed in the gas phase appear to be favored in low-dielectric solvents such as 2,2,2-triflouroethanol. The utility of ion mobility-mass spectrometry (IM-MS) as a means of rapidly distinguishing between linear and cyclic peptide forms in also discussed.
Estimation of the dimension of a noisy attractor (1994)

A simple method is proposed to estimate the correlation dimension of a noisy chaotic attractor. The method is based on the observation that the noise induces a bias in the observed distances of trajectories, which tend to appear farther apart than they are. Under the assumption of noise being strictly bounded in amplitude, this leads to a rescaling of interpoint distances on the attractor. A correlation integral function is obtained that accounts for this effect of noise. The applicability of the method is illustrated with two examples, viz., the Lorenz attractor with additive noise and experimental time series of pressure fluctuation data measured in gas-solid fluidized beds.
Acoustic evaluation of electronic plastic packages (1992)

Describe a technique of C-mode scanning acoustic microscope (CSAM) image acquisition. The role acoustic reflected wave analysis plays in the acquisition of CSAM images is considered. The effect that mold compound thickness and transducer choice have on the resolution of leadframe features in plastic packages is illustrated. Potential applications of acoustic reflected wave analysis are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Design of a railway mobile gamma source for industrial irradiations (1956)

We created a predictive model based on 10 pyroptosis-associated lncRNAs that could accurately predict the outcomes of GC patients and provide a promising treatment option in the future.
Explicit binding interface for supporting native ATM networks in a CORBA system (2002)

This paper describes a native ATM support for CORBA. The system provides three advanced features. The first feature is to extend the CORBA interface to explicitly support network bandwidth reservation provided by ATM. The second feature is to support the negotiation between a client and a server to reserve network bandwidth. The last feature is to support multiple transport protocols simultaneously. The system allows a programmer to select either IIOP to invoke methods in a best effort way or GIOP over ATM for timing critical invocations.
Tetanus toxoid-anti-tetanus toxoid complexes: a potential model to study the complement transport system for immune complex in humans. (1987)

Complement and its receptor on erythrocytes appears to play a physiological role in the elimination of large immune complexes (IC) in monkeys, and a similar system is likely to work in humans. Here we define a safe IC model which is suitable for clinical investigations. Soluble tetanus toxoid (TT)-human anti-TT (IgG) antibody complexes were prepared in large antibody excess. The size of the complexes was approximately 45 S. When incubated in normal human serum, 50% of the IC increased further in size, but remained soluble, and bound rapidly to human erythrocytes in vitro. This binding was shown to require intact classical pathway function. When injected into normal guinea-pigs a comparable proportion of IC bound immediately to blood cells (mainly to platelets). No platelet binding of IC occurred in C4-deficient guinea-pigs, but this binding was restored when C4 was supplied. Initial immune complex elimination was faster in C4 deficient than in C4-supplemented and normal guinea pigs. Thus classical pathway function appeared to be necessary for the normal processing, transport and elimination of TT-anti-TT complexes.
[Medical wastes. 2. Comparative studies of the microbial contamination of wastes from medical practices of different disciplines and household garbage]. (1990)

Medical consulting room wastes of 7 disciplines were investigated quantitatively and qualitatively for nosocomial infective agents. 20-25 samples from each consulting room were examined for 3 months. The results were compared with those of household refuse and hospital wastes. The whole content of a waste bag was suspended without a preceding sorting and the eluate was microbiologically examined. The results of the investigations proved, that the germ concentration of the medical consulting room wastes was less than that of household refuse. The median for all investigated germ groups was less than 1 log(10)-step compared-to household refuse. The statistical analyses confirmed highly significant differences (p less than 0.001) for total germ concentration, thermoresistant obligate aerobic and facultative anaerobic bacteria and bacteria spores. Exceptionally the paediatric consulting room wastes show smaller differences (p less than 0.01) between the household refuse for obligate and facultative anaerobic bacteria, thermoresistant obligate and facultative anaerobic bacteria and bacteria spores and D-streptococci. From the comparison of total germ concentration for medical wastes from conservative disciplines and household refuse resulted that wastes from medical consulting rooms are less contaminated with nosocomial infective agents than household refuse and hospital wastes. In conclusion wastes from medical consulting rooms can, similar to hospital wastes, be disposed together with household refuse.
Characterization of covalent Adriamycin-DNA adducts (1998)

Adriamycin is a popular antineoplastic agent whose ability to form covalent adducts with DNA has been correlated to cellular apoptosis (programmed cell death) in tumor models. We have isolated and purified this adduct formed under oxido-reductive (Fenton) conditions in Tris buffer. We show by homo- and heteronuclear NMR spectroscopy that the covalent Adriamycin-DNA adduct is structurally equivalent to that resulting from direct reaction with formaldehyde. Covalent linkage of the drug to one of the DNA strands confers remarkable stability to the duplex, indicated by a 162-fold reduction in the rate of strand displacement compared with the complex with noncovalently bound drug. Glyceraldehyde also engenders covalent Adriamycin-DNA complexes, providing a possible relevant biological context for in vivo adduct formation.
Temperature stability of reversed phase and normal phase stationary phases under aqueous conditions (2007)

In this study the temperature stability of several normal phase and RP columns was investigated using a water-only mobile phase. The temperature was adjusted to 120 degrees C for the bare silica stationary phases and to 185 degrees C for the metal oxide and carbon stationary phases. It could be shown that metal oxide stationary phases exhibited excellent thermal stability over the duration of the test period and are therefore suitable for high temperature LC applications.
Prolonged Half‐life of Recombinant Immunotoxins in Mice by Adding an Albumin Binding Domain (2017)

Background Reconbinant immunotoxins (RITs) are potent anti‐cancer agents, that are now in clinical trials in tumors that express CD25, CD22 or Mesothelin. The entry of antibodies and antibody‐based therapeutics into tumors is affected by their half‐life in the circulation and the size of the protein. A longer half‐life should increase tumor penetration and efficacy. Goal Because RITs have a relatively short half‐life in the circulation, we have explored the possibility of adding albumin‐binding domains (ABDs) to change their pharmacokinetics and increase their half‐life in the circulation. Approach We have inserted two different ABDs into a recombinant immunotoxin targeting CD25. These modifications can be done genetically, and require no additional step in the modified immunotoxins for the clinical use. We have measured their cytotoxic activities in vitro, half‐life in the circulation and anti‐tumor activity in mice. Results Two different expression plasmids were constructed with 2 types of ABDs. These RITs were refolded from the inclusion bodies expressed in E. coli according to the standard procedure used for other immunotoxins in clinical use. M1(dsFv)‐PE38, targeting CD25, was used as the parental molecule. The ABDs were inserted near the C‐treminus of domain III, but before the REDLK sequence essential for toxin activity. The pahamacokinetics experiments in mice showed the prolonged retention of the modified immunotoxins as expected by 3‐fold of the half‐life. Also specific cytotoxic activities of the ABD‐RITs in vitro were 2‐fold less comparing to parental unmodified RIT. Moreover, these ABD‐RITs showed similar level of nonspecific acute in mice in spite of the prolonged retention time. Antitumor experiments indicated that no significant improvement was observed by the ABD addition. Conclusion Increasing the half‐life of an immunotoxin by the insertion of an ABD does not increase its anti‐tumor activity. Insertion of an ABD into regions of the molecule that are not necessary for cytotoxicity may overcome this loss of activity. Support or Funding Information This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research.