gebhart/patrepeval huggingface dataset:
Molecular Cloning of the Oncofetal Isoform of the Human Pancreatic Bile Salt-dependent Lipase (1998)

Specific transcripts for bile salt-dependent lipase (BSDL), a 100-kDa glycoprotein secreted by the human pancreas, were immunodetected in BxPC-3 and SOJ-6 pancreatic tumoral cell lines. Sequencing of fragments, obtained by mRNA reverse transcription and amplification, confirmed the presence of BSDL transcripts in these cancer cells. The protein was detected in lysates of pancreatic tumoral cells, where it was mainly associated with membranes. Only a minute amount of the enzyme was detected in the culture media. Immunofluorescence studies demonstrated that in SOJ-6 cells, BSDL colocates with the p58 Golgi protein and suggested that the protein may be sequestrated within the Golgi compartment. These results demonstrated that BSDL is expressed in human pancreatic tumoral cells and cannot be secreted (or for the least very poorly). Subsequently, a cDNA covering the entire sequence of BSDL was obtained by reverse transcription-polymerase chain reaction. The sequence of this cDNA indicated that the N-terminal domain encoded by exons 1-10 was identical to that of BSDL expressed by the human normal pancreas. However, the sequence corresponding to exon 11, which should code for the 16 tandem-repeated identical mucin-like sequences of BSDL, was deleted by 330 base pairs (bp) and encoded only 6 of these repeated sequences. We conclude that this truncated variant of BSDL would be its oncofetal form, referred to as feto-acinar pancreatic protein. We then investigated whether the deletion of 330 bp affected the secretion of the protein. For this purpose, the cDNA corresponding to the mature form of the BSDL variant expressed in SOJ-6 cells was cloned into an expression/secretion vector and transfected into CHO-K1 cells. Results indicated that the variant of BSDL isolated from SOJ-6 cells was expressed and secreted by transfected cells. However, the level of BSDL secreted by these transfected CHO-K1 cells was significantly higher than that observed for SOJ-6 cells. Consequently, the retention of the oncofetal variant of BSDL observed in human pancreatic tumoral cells might not result from inherent properties of the protein.
MEAN AND VARIANCE OF THE FORWARD FIELDS PROPAGATED THROUGH 3D RANDOM INTERNAL WAVES WITH RAYLEIGHT-BORN SCATTERING (2004)

The mean and variance of the acoustic field forward propagated through an ocean waveguide containing random internal waves is modelled using a normal mode formulation [1] that takes into account the 3-D interaction of the acoustic field with medium inhomogeneities. The effects of dispersion, attenuation and redistribution of modal energy due to random multiple scattering in the forward azimuth are treated analytically. The inhomogeneous medium's scatter function density is modelled using the Rayleigh-Born approximation to Green's theorem to account for random fluctuations in density and compressibility caused by the internal waves. The generalized waveguide extinction theorem [2] is applied to determine the attenuation due to scattering from the internal wave inhomogeneities. Simulations for typical continental shelf environments quantitatively show how coherent and incoherent acoustic field intensities vary with range, depth and internal wave field properties
A Complex Catalytic Cycle Leading to a Regioselective Synthesis of <i>o,o</i>′‐Disubstituted Vinylarenes (1997)

Palladium(0), (II), and (IV) complexes are intermediates in the unusual palladium catalyzed synthesis of 2,6-dialkyl-substituted vinylarenes. Since these complexes discriminate between alkyl and aryl iodides and between strained and terminal olefins at certain stages of the process, this provides both a highly chemoselective and a regioselective access to 1,2,3-trisubstituted arenes (see, for example, Eq. (a)).
DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease (2012)

DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death, and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not change significantly in human plasma from patients with Parkinson disease when compared with controls. In this study, we measured total DJ-1 and its isoforms in whole blood of patients with Parkinson disease at various stages, Alzheimer disease, and healthy controls to identify potential peripheral biomarkers of PD. In an initial discovery study of 119 subjects, 7 DJ-1 isoforms were reliably detected, and blood levels of those with 4-hydroxy-2-nonenal modifications were discovered to be altered in late-stage Parkinson disease. This result was further confirmed in a validation study of another 114 participants, suggesting that, unlike total DJ-1 levels, post-translationally modified isoforms of DJ-1 from whole blood are candidate biomarkers of late-stage Parkinson disease.
[Relationships of soil moisture content with precipitation and evaporation in rehabilitated forests in degraded limestone red-soil region of Jiangxi Province]. (2008)

By using time series analysis, the relationships of 0-40 cm soil moisture content with precipitation and evaporation in four main rehabilitated forests in degraded limestone red-soil region of Xiushui County, Jiangxi Province were studied. The results showed that in the four rehabilitated forests, the previous month's soil moisture content had stronger effects on the current month's soil moisture content in 0-40 cm and 20-40 cm layers, but had lesser effects on that in 0-10 cm layer. The soil moisture content in 20-40 cm layer was mainly affected by current month's precipitation, while that in 0-10 cm layer was mainly affected by current month's evaporation. The correlation coefficient between current month's precipitation and soil moisture content was the largest in pure Liquidambar formosana plantation, and the auto-interrelation coefficient of soil moisture content was larger in mixed forests than in pure L. formosana plantation.
Functional structure of protein: Exposed vs hidden function. (1991)

The dev analysis was used to construct the functional structure of protein (3). Based on this principle, the intramolecular interaction of dev peak was investigated. Two types of peak were observed: one is the hidden peak which interacts strongly with another region of the molecule and the other is the exposed peak whose interaction was weak. Analysis was made with trypsin and its inhibitor and on the intermolecular interaction between their exposed peaks. One interaction between their exposed peaks was found to coincide with one which had been already known to be authentic between their active sites.
Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion (1997)

Thus, the appearance of atrial fibrosis and perivascular fibrosis of aorta and pulmonary artery, together with associated increase in ACE and BK receptor binding, in rats receiving AngII or ALDO suggests these responses are not related to altered ventricular wall stress or arterial hypertension, but rather to these effector hormones of the circulating renin-angiotensin-aldosterone system. Local BK, regulated by ACE found in fibrous tissue and BK receptor binding may play a role in structural remodeling of atria and great vessels in these rat models that stimulate chronic cardiac failure.
Digicounter Link—an interface for the BBC Microcomputer and a digicounter radiation counter (1992)

Why bother linking a digicounter to a computer? The simple answer is that repeated measurements of the type in radiation experiments are more easily made using a datalogger or computer. The longer and probably more truthful answer is that I had read an article in the SSSERC Bulletin and a letter in Physics Education concerning a method of measuring airborne radon using a hoover and a piece of toilet roll and had been fascinated by the idea.
<i>Civil Liberties in Canada</i> (1965)

Find information about UTP Journals. University of Toronto Press is Canada’s leading academic publisher and one of the largest university presses in North America, with particular strengths in the social sciences, humanities, and business. The Book Publishing Division is widely recognized in Canada for its strength in history, political science, sociology, Indigenous studies, and cultural studies. Internationally, UTP is a leading publisher of medieval, Renaissance, Italian, Iberian, Slavic, and urban studies, as well as studies in book and print culture.
Synthesis and Biological Activity of Hydrazone Derivatives Containing Pyrazole (2008)

Twelve novel hydrazone derivatives containing pyrazole rings have been prepared by condensing substituted-benzaldehyde with 2-(3,5-dimethyl- 1H-pyrazol-1-yl)acetohydrazide under microwave irradiation. Their structures were characterised by 1 H NMR, IR, MS and elemental analysis. The preliminary biological activity tests showed that some of the compounds showed moderate fungicidal activity.
Piperacillin, a new penicillin active against many bacteria resistant to other penicillins (1978)

The in vitro activity of piperacillin, a new semisynthetic piperazine penicillin derivative, was evaluated against 626 clinical isolates and compared with the activity of other beta-lactam antibiotics. At a concentration of 0.1 microgram/ml, piperacillin inhibited all streptococci except enterococci. Non-beta-lactamase-producing staphylococci were inhibited by 1.6 microgram or less per ml. Both beta-lactamase- and non-beta-lactamase-producing Haemophilus were inhibited by 0.1 microgram/ml. Piperacillin inhibited non-beta-lactamase-producing Escherichia coli, Salmonella, and Shigella at a concentration of 6.3 micrograms/ml, but 20% of strains of these species containing type III beta-lactamase were not inhibited by 100 micrograms/ml. Piperacillin at 25 micrograms/ml, inhibited 83% of Citrobacter, 58% of Klebsiella, 88% of Enterobacter, and 50% of indole-positive Proteus, Acinetobacter, and Providencia. At 25 micrograms/ml, piperacillin inhibited 95% of Pseudomonas aeruginosa and 78% of Bacteroides fragilis. The minimal inhibitory concentration of piperacillin against Pseudomonas was affected by increasing the inoculum size and by pH. Minimum bactericidal concentrations against Pseudomonas and Serratia often were eightfold greater than the minimum inhibitory concentrations. Piperacillin was equal in activity to ampicillin against enterococci. It was more active than carbenicillin against E. coli, Klebsiella, Enterobacter, and Bacteroides. It was the most active penicillin against Pseudomonas and inhibited many strains of Pseudomonas for which the MICs of carbenicillin were above 200 micrograms/ml. Piperacillin was hydrolyzed by many different beta-lactamases. Synergistic activity of piperacillin was demonstrated when it was combined with amikacin, gentamicin, and cefazolin against P. aeruginosa and members of the Enterobacteriaceae. No antagonism was observed when piperacillin was combined with aminoglycosides; however, antagonism was observed rarely against E. coli when piperacillin was combined with cefazolin.
Tandem Carbonylation Reactions:  Hydroformylation and Hydroaminomethylation of Alkenes Catalyzed by Cationic [(H<sub>2</sub>C(3,5-Me<sub>2</sub>pz)<sub>2</sub>)Rh(CO)L]<sup>+</sup>Complexes (2003)

Addition of H2C(3,5-Me2pz)2 (Bpm*) to [(η4-1,5-COD)Rh(acetone)2]BF4 affords the complex [Bpm*Rh(COD)]BF4, which is carbonylated under mild conditions into [Bpm*Rh(CO)2]BF4. One of the CO ligands can be easily displaced by PPh3, PMePh2, or P(OMe)3. The X-ray structures of [Bpm*Rh(CO)2]BF4 and [Bpm*Rh(CO)(PPh3)]BF4 have been determined and show a rhodium center in a square-planar environment. These complexes have been fully characterized by infrared and 1H, 13C, and 31P NMR spectroscopy. They are rather active precursors for the hydroformylation of oct-1-ene. They also promote the hydroaminomethylation reaction of terminal alkenes: i.e., the direct production of alkylamines from successive hydroformylation, condensation of the resulting aldehydes with diethylamine, and hydrogenation of the enamines. (2-Methyloctyl)diethylamine and nonyldiethylamine are obtained from oct-1-ene/H2/CO/NHEt2 building blocks. The reaction rate can be significantly increased on addition of [RuH2(PPh3)4], which acts presumably as a hydride-donating species.
Friction welding – critical assessment of literature (2007)

Friction welding is now well established as a means of joining many different types of materials, because it has proved itself to be a reliable and economical way of producing high quality welds. The present paper introduces different friction welding processes, their advantages and shortcomings. The history of friction welding and typical applications are also reviewed. In the context of friction welding, a number of subjects, such as frictional behaviour, joining mechanism, interface temperature and heat generation, still exist, where different concepts for explanation of the physical mechanisms have been proposed by different investigators. To clarify some inconsistencies in the interpretation of the friction welding process, a thorough review and critical assessment of the literature associated with this process is attempted.
Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody (2013)

The 2H2 monoclonal antibody recognizes the precursor peptide on immature dengue virus and might therefore be a useful tool for investigating the conformational change that occurs when the immature virus enters an acidic environment. During dengue virus maturation, spiky, immature, noninfectious virions change their structure to form smooth-surfaced particles in the slightly acidic environment of the trans-Golgi network, thereby allowing cellular furin to cleave the precursor-membrane proteins. The dengue virions become fully infectious when they release the cleaved precursor peptide upon reaching the neutral-pH environment of the extracellular space. Here we report on the cryo-electron microscopy structures of the immature virus complexed with the 2H2 antigen binding fragments (Fab) at different concentrations and under various pH conditions. At neutral pH and a high concentration of Fab molecules, three Fab molecules bind to three precursor-membrane proteins on each spike of the immature virus. However, at a low concentration of Fab molecules and pH 7.0, only two Fab molecules bind to each spike. Changing to a slightly acidic pH caused no detectable change of structure for the sample with a high Fab concentration but caused severe structural damage to the low-concentration sample. Therefore, the 2H2 Fab inhibits the maturation process of immature dengue virus when Fab molecules are present at a high concentration, because the three Fab molecules on each spike hold the precursor-membrane molecules together, thereby inhibiting the normal conformational change that occurs during maturation.
Quantum Communications in Future Networks and Services (2020)

Over the last few years, we have witnessed an impressive growth of data traffic and a progressive Digital Transformation of Industry and Society: the deployment of the ultra-broadband and low latency network infrastructures (e.g., 5G) are leading to a global digitalization of several domains. These techno-economic trends are expected to continue and even accelerate in the next decade, at end of which, 6G and smart networks and services will be exploited. Innovation will continue to drive the global economy into the next decade. This paper draws some technology trends and applications scenarios for this horizon, where Quantum Optical Communications are likely to disrupt Information and Communications Technology (ICT) and Telecommunications. Among the enabling technologies and solutions moving in this direction, this paper briefly addresses: quantum optical switching and computing, THz-to-optical conversions and advanced metamaterials for smart radio-optical programmable environments and Artificial Intelligence. The paper concludes with the description of a future application scenario, called Quantum Optical Twin, where the above Quantum Optical Communications technologies are exploited to provide services such as: ultra-massive scale communications for connected spaces and ambient intelligence, holographic telepresence, tactile Internet, new paradigms of brain computer interactions, innovative forms of communications.
An Immunohistochemical Study of Architectural Remodeling and Connective Tissue Synthesis in Pulmonary Fibrosis (1989)

Fibroblasts in healthy adult lung are quiescent, synthesizing little collagen. We studied lung biopsies from 30 patients with pulmonary fibrosis, using immunohistochemistry with monoclonal antibodies against the propeptides of type I collagen to localize fibroblasts actively synthesizing collagen. Adjacent sections were stained with antibodies to type III and IV collagen, fibrin, cytokeratin, plasma fibronectin, or EDIIIa-containing "cellular" fibronectin (cFN). In rapid pulmonary fibrosis, including the proliferative phase of diffuse alveolar damage, organizing pneumonia, and subacute idiopathic fibrosis, collagen-synthesizing cells were numerous in organizing exudate filling airspaces but were also seen in the interstitium of the alveolar walls, interlobular septa, and walls of blood vessels. The new matrix deposited in the airspaces also contained type III collagen and EDIIIa-containing fibronectin. In chronic pulmonary fibrosis, more than half of the biopsies showed foci of collagen synthesis and cFN deposition near the air-tissue interface. The foci were consistently localized outside remnants of basal lamina and therefore within airspaces. The results indicate that (1) fibrosis in chronic idiopathic pulmonary fibrosis results mainly from organization of exudate within airspaces, just as it does after acute lung injury, and (2) during this process, fibroblasts increase their synthesis of collagen and fibronectin coordinately. Foci of active matrix deposition provide evidence for the progressive nature of chronic pulmonary fibrosis.
The effect of strategic interdependence on subsidiary mandate change (2016)

This study examines the impact of intra-multinational enterprise (MNE) dynamics on subsidiary mandate change. We explore the complex dynamics of heterarchy relationship by incorporating both cooperative and competitive logics. In mutual mandate operation, we identify that strategic interdependence between subsidiaries significantly affects mandate gain and loss. With focus on both subsidiary and mandate levels, we pay particular attention to competitive dynamics of intra-MNE relations. Based on a sample of 16,385 subsidiaries of 631 Japanese MNEs from 1991 to 2014, the findings confirm that subsidiaries redefine their mandate portfolio in response to strategic moves of other subsidiaries.
Does Smoking Tighten the Gut? (1989)

There is a low prevalence of smoking in ulcerative colitis. The disease often starts or relapses after stopping smoking. Increased intestinal permeability for harmful substances has been proposed as one causal factor in ulcerative colitis. We therefore wanted to study the relationship between smoking and intestinal permeability in healthy subjects. In 25 smoking and 25 non-smoking healthy persons urine recoveries of two different oral probes, 51Cr-ethylenediaminetetraacetic acid (51Cr-EDTA) and low-molecular-weight polymers of polyethylene glycol (PEG 400), were measured. The smokers had significantly lower 24-h urine recoveries of 51Cr-EDTA than the non-smokers (median, 1.6; range, 0.8-4.2, versus 2.1; range, 1.1-5.8; 2 p less than 0.001). In contrast, 6-h urine recoveries of PEG 400 were not significantly different in smokers and non-smokers. Thus, smoking appears to tighten the gut either by effects on the paracellular junctions in the intestinal epithelium or by decreasing the permeability in the distal small bowel and the colon.
Contribution of Feedback and Feedforward Strategies to Locomotor Adaptations (2006)

The aim of this study was to examine the strategies used by human subjects to adapt their walking pattern to a velocity-dependent resistance applied against hip and knee movements. Subjects first walked on a treadmill with their lower limbs strapped to an exoskeletal robotic gait orthosis with no resistance against leg motions (null condition). Afterward, a velocity-dependent resistance was applied against left hip and knee movements (force condition). Catch trials were interspersed throughout the experiment to track the development of adaptive changes in the walking pattern. After 188 steps in the force condition, subjects continued to step in the null condition for another 100 steps (washout period). Leg muscle activity and joint kinematics were recorded and analyzed. The adaptive modifications in the locomotor pattern suggest the involvement of both feedback and feedforward control strategies. Feedback-driven adaptations were reflected in increases in rectus femoris and tibialis anterior activity during swing, which occurred immediately, only in the presence of resistance, and not during the catch trials. Locomotor adaptations involving feedforward strategies were reflected in enhanced pre-swing activity in the biceps femoris and medial hamstrings muscles, which required experience and persisted in the catch trials. During washout subjects showed a gradual deadaptation of locomotor activity to control levels. In summary, adaptive changes in the walking pattern were driven by both feedback and feedforward adjustments in the walking pattern appropriate for overcoming the effects of resistance.
THE ACTIVE PRINCIPLES OF THE POSTERIOR LOBE OF THE PITUITARY GLAND.<sup>1</sup> I. THE DEMONSTRATION OF THE PRESENCE OF TWO ACTIVE PRINCIPLES. II. THE SEPARATION OF THE TWO PRINCIPLES AND THEIR CONCENTRATION IN THE FORM OF POTENT SOLID PREPARATIONS (1928)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE ACTIVE PRINCIPLES OF THE POSTERIOR LOBE OF THE PITUITARY GLAND.1 I. THE DEMONSTRATION OF THE PRESENCE OF TWO ACTIVE PRINCIPLES. II. THE SEPARATION OF THE TWO PRINCIPLES AND THEIR CONCENTRATION IN THE FORM OF POTENT SOLID PREPARATIONSOliver Kamm, T. B. Aldrich, I. W. Grote, L. W. Rowe, and E. P. BugbeeCite this: J. Am. Chem. Soc. 1928, 50, 2, 573–601Publication Date (Print):February 1, 1928Publication History Published online1 May 2002Published inissue 1 February 1928https://pubs.acs.org/doi/10.1021/ja01389a050https://doi.org/10.1021/ja01389a050research-articleACS PublicationsRequest reuse permissionsArticle Views206Altmetric-Citations226LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts